WorldWideScience

Sample records for cells system integrated

  1. Coal Integrated Gasification Fuel Cell System Study

    Energy Technology Data Exchange (ETDEWEB)

    Chellappa Balan; Debashis Dey; Sukru-Alper Eker; Max Peter; Pavel Sokolov; Greg Wotzak

    2004-01-31

    This study analyzes the performance and economics of power generation systems based on Solid Oxide Fuel Cell (SOFC) technology and fueled by gasified coal. System concepts that integrate a coal gasifier with a SOFC, a gas turbine, and a steam turbine were developed and analyzed for plant sizes in excess of 200 MW. Two alternative integration configurations were selected with projected system efficiency of over 53% on a HHV basis, or about 10 percentage points higher than that of the state-of-the-art Integrated Gasification Combined Cycle (IGCC) systems. The initial cost of both selected configurations was found to be comparable with the IGCC system costs at approximately $1700/kW. An absorption-based CO2 isolation scheme was developed, and its penalty on the system performance and cost was estimated to be less approximately 2.7% and $370/kW. Technology gaps and required engineering development efforts were identified and evaluated.

  2. Coal Integrated Gasification Fuel Cell System Study

    Energy Technology Data Exchange (ETDEWEB)

    Chellappa Balan; Debashis Dey; Sukru-Alper Eker; Max Peter; Pavel Sokolov; Greg Wotzak

    2004-01-31

    This study analyzes the performance and economics of power generation systems based on Solid Oxide Fuel Cell (SOFC) technology and fueled by gasified coal. System concepts that integrate a coal gasifier with a SOFC, a gas turbine, and a steam turbine were developed and analyzed for plant sizes in excess of 200 MW. Two alternative integration configurations were selected with projected system efficiency of over 53% on a HHV basis, or about 10 percentage points higher than that of the state-of-the-art Integrated Gasification Combined Cycle (IGCC) systems. The initial cost of both selected configurations was found to be comparable with the IGCC system costs at approximately $1700/kW. An absorption-based CO2 isolation scheme was developed, and its penalty on the system performance and cost was estimated to be less approximately 2.7% and $370/kW. Technology gaps and required engineering development efforts were identified and evaluated.

  3. Integral reactor system and method for fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Fernandes, Neil Edward; Brown, Michael S.; Cheekatamaria, Praveen; Deng, Thomas; Dimitrakopoulos, James; Litka, Anthony F.

    2017-03-07

    A reactor system is integrated internally within an anode-side cavity of a fuel cell. The reactor system is configured to convert higher hydrocarbons to smaller species while mitigating the lower production of solid carbon. The reactor system may incorporate one or more of a pre-reforming section, an anode exhaust gas recirculation device, and a reforming section.

  4. Integral reactor system and method for fuel cells

    Science.gov (United States)

    Fernandes, Neil Edward; Brown, Michael S; Cheekatamarla, Praveen; Deng, Thomas; Dimitrakopoulos, James; Litka, Anthony F

    2013-11-19

    A reactor system is integrated internally within an anode-side cavity of a fuel cell. The reactor system is configured to convert hydrocarbons to smaller species while mitigating the lower production of solid carbon. The reactor system may incorporate one or more of a pre-reforming section, an anode exhaust gas recirculation device, and a reforming section.

  5. Integrating fuel cell power systems into building physical plants

    Energy Technology Data Exchange (ETDEWEB)

    Carson, J. [KCI Technologies, Inc., Hunt Valley, MD (United States)

    1996-12-31

    This paper discusses the integration of fuel cell power plants and absorption chillers to cogenerate chilled water or hot water/steam for all weather air conditioning as one possible approach to building system applications. Absorption chillers utilize thermal energy in an absorption based cycle to chill water. It is feasible to use waste heat from fuel cells to provide hydronic heating and cooling. Performance regimes will vary as a function of the supply and quality of waste heat. Respective performance characteristics of fuel cells, absorption chillers and air conditioning systems will define relationships between thermal and electrical load capacities for the combined systems. Specifically, this paper develops thermodynamic relationships between bulk electrical power and cooling/heating capacities for combined fuel cell and absorption chiller system in building applications.

  6. Heat recovery subsystem and overall system integration of fuel cell on-site integrated energy systems

    Science.gov (United States)

    Mougin, L. J.

    1983-01-01

    The best HVAC (heating, ventilating and air conditioning) subsystem to interface with the Engelhard fuel cell system for application in commercial buildings was determined. To accomplish this objective, the effects of several system and site specific parameters on the economic feasibility of fuel cell/HVAC systems were investigated. An energy flow diagram of a fuel cell/HVAC system is shown. The fuel cell system provides electricity for an electric water chiller and for domestic electric needs. Supplemental electricity is purchased from the utility if needed. An excess of electricity generated by the fuel cell system can be sold to the utility. The fuel cell system also provides thermal energy which can be used for absorption cooling, space heating and domestic hot water. Thermal storage can be incorporated into the system. Thermal energy is also provided by an auxiliary boiler if needed to supplement the fuel cell system output. Fuel cell/HVAC systems were analyzed with the TRACE computer program.

  7. Microfluidic cell culture systems with integrated sensors for drug screening

    Science.gov (United States)

    Grist, Samantha; Yu, Linfen; Chrostowski, Lukas; Cheung, Karen C.

    2012-03-01

    Cell-based testing is a key step in drug screening for cancer treatments. A microfluidic platform can permit more precise control of the cell culture microenvironment, such as gradients in soluble factors. These small-scale devices also permit tracking of low cell numbers. As a new screening paradigm, a microscale system for integrated cell culture and drug screening promises to provide a simple, scalable tool to apply standardized protocols used in cellular response assays. With the ability to dynamically control the microenvironment, we can create temporally varying drug profiles to mimic physiologically measured profiles. In addition, low levels of oxygen in cancerous tumors have been linked with drug resistance and decreased likelihood of successful treatment and patient survival. Our work also integrates a thin-film oxygen sensor with a microfluidic oxygen gradient generator which will in future allow us to create spatial oxygen gradients and study effects of hypoxia on cell response to drug treatment. In future, this technology promises to improve cell-based validation in the drug discovery process, decreasing the cost and increasing the speed in screening large numbers of compounds.

  8. Economic competitiveness of fuel cell onsite integrated energy systems

    Science.gov (United States)

    Bollenbacher, G.

    1983-01-01

    The economic competitiveness of fuel cell onsite integrated energy systems (OS/IES) in residential and commercial buildings is examined. The analysis is carried out for three different buildings with each building assumed to be at three geographic locations spanning a range of climatic conditions. Numerous design options and operating strategies are evaluated and two economic criteria are used to measure economic performance. In general the results show that fuel cell OS/IES's are competitive in most regions of the country if the OS/IES is properly designed. The preferred design is grid connected, makes effective use of the fuel cell's thermal output, and has a fuel cell powerplant sized for the building's base electrical load.

  9. Microfluidics and cancer analysis: cell separation, cell/tissue culture, cell mechanics, and integrated analysis systems.

    Science.gov (United States)

    Pappas, Dimitri

    2016-01-21

    Among the growing number of tools available for cancer studies, microfluidic systems have emerged as a promising analytical tool to elucidate cancer cell and tumor function. Microfluidic methods to culture cells have created approaches to provide a range of environments from single-cell analysis to complex three-dimensional devices. In this review we discuss recent advances in tumor cell culture, cancer cell analysis, and advanced studies enabled by microfluidic systems.

  10. Baculovirus integration with the vertebrate cells in system in vitro

    Directory of Open Access Journals (Sweden)

    Strokovskaya L. I.

    2010-11-01

    Full Text Available In this review the literature data are analyzed relative to the study of a new vector system for the cells of vertebrates, based on the insect viruses – baculoviruses. The ways and mechanisms of recombinant baculoviruses penetration into cells, the factors, which influence the effectiveness of transduction, the principles of the modification of virus display, and the reaction of the different types of cells on virus introduction are examined. The prospects of using recombinant baculoviruses in cellular engineering are discussed.

  11. Integrated Solid Oxide Fuel Cell Power System Characteristics Prediction

    Directory of Open Access Journals (Sweden)

    Marian GAICEANU

    2009-07-01

    Full Text Available The main objective of this paper is to deduce the specific characteristics of the CHP 100kWe Solid Oxide Fuel Cell (SOFC Power System from the steady state experimental data. From the experimental data, the authors have been developed and validated the steady state mathematical model. From the control room the steady state experimental data of the SOFC power conditioning are available and using the developed steady state mathematical model, the authors have been obtained the characteristic curves of the system performed by Siemens-Westinghouse Power Corporation. As a methodology the backward and forward power flow analysis has been employed. The backward power flow makes possible to obtain the SOFC power system operating point at different load levels, resulting as the load characteristic. By knowing the fuel cell output characteristic, the forward power flow analysis is used to predict the power system efficiency in different operating points, to choose the adequate control decision in order to obtain the high efficiency operation of the SOFC power system at different load levels. The CHP 100kWe power system is located at Gas Turbine Technologies Company (a Siemens Subsidiary, TurboCare brand in Turin, Italy. The work was carried out through the Energia da Ossidi Solidi (EOS Project. The SOFC stack delivers constant power permanently in order to supply the electric and thermal power both to the TurboCare Company and to the national grid.

  12. Cell Culture Systems To Study Human Herpesvirus 6A/B Chromosomal Integration.

    Science.gov (United States)

    Gravel, Annie; Dubuc, Isabelle; Wallaschek, Nina; Gilbert-Girard, Shella; Collin, Vanessa; Hall-Sedlak, Ruth; Jerome, Keith R; Mori, Yasuko; Carbonneau, Julie; Boivin, Guy; Kaufer, Benedikt B; Flamand, Louis

    2017-07-15

    Human herpesviruses 6A/B (HHV-6A/B) can integrate their viral genomes in the telomeres of human chromosomes. The viral and cellular factors contributing to HHV-6A/B integration remain largely unknown, mostly due to the lack of efficient and reproducible cell culture models to study HHV-6A/B integration. In this study, we characterized the HHV-6A/B integration efficiencies in several human cell lines using two different approaches. First, after a short-term infection (5 h), cells were processed for single-cell cloning and analyzed for chromosomally integrated HHV-6A/B (ciHHV-6A/B). Second, cells were infected with HHV-6A/B and allowed to grow in bulk for 4 weeks or longer and then analyzed for the presence of ciHHV-6. Using quantitative PCR (qPCR), droplet digital PCR, and fluorescent in situ hybridization, we could demonstrate that HHV-6A/B integrated in most human cell lines tested, including telomerase-positive (HeLa, MCF-7, HCT-116, and HEK293T) and telomerase-negative cell lines (U2OS and GM847). Our results also indicate that inhibition of DNA replication, using phosphonoacetic acid, did not affect HHV-6A/B integration. Certain clones harboring ciHHV-6A/B spontaneously express viral genes and proteins. Treatment of cells with phorbol ester or histone deacetylase inhibitors triggered the expression of many viral genes, including U39, U90, and U100, without the production of infectious virus, suggesting that the tested stimuli were not sufficient to trigger full reactivation. In summary, both integration models yielded comparable results and should enable the identification of viral and cellular factors contributing to HHV-6A/B integration and the screening of drugs influencing viral gene expression, as well as the release of infectious HHV-6A/B from the integrated state.IMPORTANCE The analysis and understanding of HHV-6A/B genome integration into host DNA is currently limited due to the lack of reproducible and efficient viral integration systems. In the

  13. Dye-Sensitized Solar Cell with Integrated Triplet-Triplet Annihilation Upconversion System.

    Science.gov (United States)

    Nattestad, Andrew; Cheng, Yuen Yap; MacQueen, Rowan W; Schulze, Tim F; Thompson, Fletcher W; Mozer, Attila J; Fückel, Burkhard; Khoury, Tony; Crossley, Maxwell J; Lips, Klaus; Wallace, Gordon G; Schmidt, Timothy W

    2013-06-20

    Photon upconversion (UC) by triplet-triplet annihilation (TTA-UC) is employed in order to enhance the response of solar cells to sub-bandgap light. Here, we present the first report of an integrated photovoltaic device, combining a dye-sensitized solar cell (DSC) and TTA-UC system. The integrated device displays enhanced current under sub-bandgap illumination, resulting in a figure of merit (FoM) under low concentration (3 suns), which is competitive with the best values recorded to date for nonintegrated systems. Thus, we demonstrate both the compatibility of DSC and TTA-UC and a viable method for device integration.

  14. Fuel cell on-site integrated energy system parametric analysis of a residential complex

    Science.gov (United States)

    Simons, S. N.

    1977-01-01

    The use of phosphoric acid fuel cell powerplant to provide all the electricity required by an 81-unit garden apartment complex is studied. Byproduct heat is recovered and provides some of the heat required by the complex. The onsite integrated energy system contains energy conversion equipment including combinations of compression and absorption chillers, heat pumps, electric resistance heaters, and thermal storage. The annual fuel requirement for several onsite integrated energy systems as well as the fuel cell breakeven cost for one specific system were calculated. It is found that electrical efficiency cannot be traded off against thermal efficiency without paying a penalty in system efficiency.

  15. Design considerations for a 10-kW integrated hydrogen-oxygen regenerative fuel cell system

    Science.gov (United States)

    Hoberecht, M. A.; Miller, T. B.; Rieker, L. L.; Gonzalez-Sanabria, O. D.

    1984-01-01

    Integration of an alkaline fuel cell subsystem with an alkaline electrolysis subsystem to form a regenerative fuel cell (RFC) system for low earth orbit (LEO) applications characterized by relatively high overall round trip electrical efficiency, long life, and high reliability is possible with present state of the art technology. A hypothetical 10 kW system computer modeled and studied based on data from ongoing contractual efforts in both the alkaline fuel cell and alkaline water electrolysis areas. The alkaline fuel cell technology is under development utilizing advanced cell components and standard Shuttle Orbiter system hardware. The alkaline electrolysis technology uses a static water vapor feed technique and scaled up cell hardware is developed. The computer aided study of the performance, operating, and design parameters of the hypothetical system is addressed.

  16. A data integration approach for cell cycle analysis oriented to model simulation in systems biology

    Directory of Open Access Journals (Sweden)

    Mosca Ettore

    2007-08-01

    Full Text Available Abstract Background The cell cycle is one of the biological processes most frequently investigated in systems biology studies and it involves the knowledge of a large number of genes and networks of protein interactions. A deep knowledge of the molecular aspect of this biological process can contribute to making cancer research more accurate and innovative. In this context the mathematical modelling of the cell cycle has a relevant role to quantify the behaviour of each component of the systems. The mathematical modelling of a biological process such as the cell cycle allows a systemic description that helps to highlight some features such as emergent properties which could be hidden when the analysis is performed only from a reductionism point of view. Moreover, in modelling complex systems, a complete annotation of all the components is equally important to understand the interaction mechanism inside the network: for this reason data integration of the model components has high relevance in systems biology studies. Description In this work, we present a resource, the Cell Cycle Database, intended to support systems biology analysis on the Cell Cycle process, based on two organisms, yeast and mammalian. The database integrates information about genes and proteins involved in the cell cycle process, stores complete models of the interaction networks and allows the mathematical simulation over time of the quantitative behaviour of each component. To accomplish this task, we developed, a web interface for browsing information related to cell cycle genes, proteins and mathematical models. In this framework, we have implemented a pipeline which allows users to deal with the mathematical part of the models, in order to solve, using different variables, the ordinary differential equation systems that describe the biological process. Conclusion This integrated system is freely available in order to support systems biology research on the cell cycle and

  17. Robust path integration in the entorhinal grid cell system with hippocampal feed-back.

    Science.gov (United States)

    Samu, Dávid; Eros, Péter; Ujfalussy, Balázs; Kiss, Tamás

    2009-07-01

    Animals are able to update their knowledge about their current position solely by integrating the speed and the direction of their movement, which is known as path integration. Recent discoveries suggest that grid cells in the medial entorhinal cortex might perform some of the essential underlying computations of path integration. However, a major concern over path integration is that as the measurement of speed and direction is inaccurate, the representation of the position will become increasingly unreliable. In this paper, we study how allothetic inputs can be used to continually correct the accumulating error in the path integrator system. We set up the model of a mobile agent equipped with the entorhinal representation of idiothetic (grid cell) and allothetic (visual cells) information and simulated its place learning in a virtual environment. Due to competitive learning, a robust hippocampal place code emerges rapidly in the model. At the same time, the hippocampo-entorhinal feed-back connections are modified via Hebbian learning in order to allow hippocampal place cells to influence the attractor dynamics in the entorhinal cortex. We show that the continuous feed-back from the integrated hippocampal place representation is able to stabilize the grid cell code.

  18. An integrated on-line irradiation and in situ live cell imaging system

    Science.gov (United States)

    Liang, Ying; Fu, Qibin; Wang, Weikang; Liu, Yu; Liu, Feng; Yang, Gen; Wang, Yugang

    2015-09-01

    Ionizing radiation poses a threat to genome integrity by introducing DNA damages, particularly DNA double-strand breaks (DSB) in cells. Understanding how cells react to DSB and maintain genome integrity is of major importance, since increasing evidences indicate the links of DSB with genome instability and cancer predispositions. However, tracking the dynamics of DNA damages and repair response to ionizing radiation in individual cell is difficult. Here we describe the development of an on-line irradiation and in situ live cell imaging system based on isotopic sources at Institute of Heavy Ion Physics, Peking University. The system was designed to irradiate cells and in situ observe the cellular responses to ionizing radiation in real time. On-line irradiation was achieved by mounting a metal framework that hold an isotopic γ source above the cell culture dish for γ irradiation; or by integrating an isotopic α source to an objective lens under the specialized cell culture dish for α irradiation. Live cell imaging was performed on a confocal microscope with an environmental chamber installed on the microscope stage. Culture conditions in the environment chamber such as CO2, O2 concentration as well as temperature are adjustable, which further extends the capacity of the system and allows more flexible experimental design. We demonstrate the use of this system by tracking the DSB foci formation and disappearance in individual cells after exposure to irradiation. On-line irradiation together with in situ live cell imaging in adjustable culture conditions, the system overall provides a powerful tool for investigation of cellular and subcellular response to ionizing radiation under different physiological conditions such as hyperthermia or hypoxia.

  19. An integrated on-line irradiation and in situ live cell imaging system

    Energy Technology Data Exchange (ETDEWEB)

    Liang, Ying; Fu, Qibin; Wang, Weikang; Liu, Yu; Liu, Feng; Yang, Gen, E-mail: gen.yang@pku.edu.cn; Wang, Yugang

    2015-09-01

    Ionizing radiation poses a threat to genome integrity by introducing DNA damages, particularly DNA double-strand breaks (DSB) in cells. Understanding how cells react to DSB and maintain genome integrity is of major importance, since increasing evidences indicate the links of DSB with genome instability and cancer predispositions. However, tracking the dynamics of DNA damages and repair response to ionizing radiation in individual cell is difficult. Here we describe the development of an on-line irradiation and in situ live cell imaging system based on isotopic sources at Institute of Heavy Ion Physics, Peking University. The system was designed to irradiate cells and in situ observe the cellular responses to ionizing radiation in real time. On-line irradiation was achieved by mounting a metal framework that hold an isotopic γ source above the cell culture dish for γ irradiation; or by integrating an isotopic α source to an objective lens under the specialized cell culture dish for α irradiation. Live cell imaging was performed on a confocal microscope with an environmental chamber installed on the microscope stage. Culture conditions in the environment chamber such as CO{sub 2}, O{sub 2} concentration as well as temperature are adjustable, which further extends the capacity of the system and allows more flexible experimental design. We demonstrate the use of this system by tracking the DSB foci formation and disappearance in individual cells after exposure to irradiation. On-line irradiation together with in situ live cell imaging in adjustable culture conditions, the system overall provides a powerful tool for investigation of cellular and subcellular response to ionizing radiation under different physiological conditions such as hyperthermia or hypoxia.

  20. Technology development for phosphoric acid fuel cell powerplant (phase 2). [on site integrated energy systems

    Science.gov (United States)

    Christner, L.

    1980-01-01

    Progress is reported in the development of material, cell components, and reformers for on site integrated energy systems. Internal resistance and contact resistance were improved. Dissolved gases (O2, N2, and CO2) were found to have no effect on the electrochemical corrosion of phenolic composites. Stack performance was increased by 100 mV over the average 1979 level.

  1. Integrated Antenna/Solar Array Cell (IA/SAC) System for Flexible Access Communications

    Science.gov (United States)

    Lee, Ricard Q.; Clark, Eric B.; Pal, Anna Maria T.; Wilt, David M.; Mueller, Carl H.

    2004-01-01

    Present satellite communications systems normally use separate solar cells and antennas. Since solar cells generally account for the largest surface area of the spacecraft, co-locating the antenna and solar cells on the same substrate opens the possibility for a number of data-rate-enhancing communications link architecture that would have minimal impact on spacecraft weight and size. The idea of integrating printed planar antenna and solar array cells on the same surface has been reported in the literature. The early work merely attempted to demonstrate the feasibility by placing commercial solar cells besides a patch antenna. Recently, Integrating multiple antenna elements and solar cell arrays on the same surface was reported for both space and terrestrial applications. The application of photovoltaic solar cell in a planar antenna structure where the radiating patch antenna is replaced by a Si solar cell has been demonstrated in wireless communication systems (C. Bendel, J. Kirchhof and N. Henze, 3rd Would Photovotaic Congress, Osaka, Japan, May 2003). Based on a hybrid approach, a 6x1 slot array with circularly polarized crossdipole elements co-located on the same surface of the solar cells array has been demonstrated (S. Vaccaro, J. R. Mosig and P. de Maagt, IEEE Trans. Ant. and Propag., Vol. 5 1, No. 8, Aug. 2003). Amorphous silicon solar cells with about 5-10% efficiency were used in these demonstrations. This paper describes recent effort to integrate advanced solar cells with printed planar antennas. Compared to prior art, the proposed WSAC concept is unique in the following ways: 1) Active antenna element will be used to achieve dynamic beam steering; 2) High efficiency (30%) GaAs multi-junction solar cells will be used instead of Si, which has an efficiency of about 15%; 3) Antenna and solar cells are integrated on a common GaAs substrate; and 4) Higher data rate capability. The IA/SAC is designed to operate at X-band (8-12 GH) and higher frequencies

  2. An integrated system for synchronous culture of animal cells under controlled conditions.

    Science.gov (United States)

    Mendoza-Pérez, Elena; Hernández, Vanessa; Palomares, Laura A; Serrato, José A

    2016-01-01

    The cell cycle has fundamental effects on cell cultures and their products. Tools to synchronize cultured cells allow the study of cellular physiology and metabolism at particular cell cycle phases. However, cells are most often arrested by methods that alter their homeostasis and are then cultivated in poorly controlled environments. Cell behavior could then be affected by the synchronization method and culture conditions used, and not just by the particular cell cycle phase under study. Moreover, only a few viable cells are recovered. Here, we designed an integrated system where a large number of cells from a controlled bioreactor culture is separated by centrifugal elutriation at high viabilities. In contrast to current elutriation methods, cells are injected directly from a bioreactor into an injection loop, allowing the introduction of a large number of cells into the separation chamber without stressful centrifugation. A low pulsation peristaltic pump increases the stability of the elutriation chamber. Using this approach, a large number of healthy cells at each cell cycle phase were obtained, allowing their direct inoculation into fully instrumented bioreactors. Hybridoma cells synchronized and cultured in this system behaved as expected for a synchronous culture.

  3. A compactly integrated flow cell with a chemiluminescent FIA system for determining lactate concentration in serum.

    Science.gov (United States)

    Nakamura, H; Murakami, Y; Yokoyama, K; Tamiya, E; Karube, I; Suda, M; Uchiyama, S

    2001-01-15

    We have fabricated an integrated flow cell as a total microanalysis system (microTAS). This flow cell (size, 15 x 20 mm; total inner volume, 12.2 microL) was designed for a rational analyzing system of lactate determination for serum. This cell was made by micromachining techniques and consisted of two hollows of a lactate oxidase (LOD) reactor and a mixing cell, a spiral groove, and three penetrated holes. To form the reactor and capillary, these patterns, etched on a silicon wafer, were attached to a glass plate by the anodic bonding method. A photodiode was put under part of the spiral capillary. The compactly accumulated devices were integrated into a flow injection analysis (FIA) system. In the flow cell, lactate was catalyzed to pyruvate and hydrogen peroxide at the LOD reactor; subsequently, hydrogen peroxide reacted with the luminol-ferricyanic reagent at the mixing cell. The resulting chemiluminescent light was detected by the photodiode. Using the miniaturized flow cell, the sample volume for one measurement was greatly reduced to 0.2 microL. The response to lactate was obtained within 30 s and was linear between 0.5 and 5.0 mM (4.5 and 45 mg/dL) lactate with excellent correlative variances of 3.2% (average of three measurements at 5.0 mM). For practical application, the lactate concentration in control human serum was determined using this system. The results showed a good correlation coefficient (r = 0.979) with the results obtained by the spectrophotometric reference method. No difference in sera (normal or pathological) was found. Consequently, this integrated flow cell shows potential as a clinical device for lactate determination in serum. In this article, the effect of the design on the chemiluminescent FIA system is also described.

  4. Modeling, control and integration of a portable solid oxide fuel cell system

    Science.gov (United States)

    Adhikari, Puran

    This thesis presents an innovative method for the modeling, control and integration of a portable hybrid solid oxide fuel cell system. The control and integration of the fuel cell system is important not only for its efficient operation, but also for issues related to safety and reliability. System modeling is needed in order to facilitate the controller design. Mathematical models of the various components of the system are built in the matlab/simulink environment. Dynamic modeling of the fuel cell stack, catalytic partial oxidation (CPOX) reformer, heat exchanger, tail gas combustor and tail gas splitter of the balance of plant system is performed first. Followed by, modeling of the three input DC/DC converter and energy storage devices (battery and supercapacitor). A two-level control approach, higher level and lower level, is adopted in this research. Each of the two major subsystems, balance of plant subsystem and power electronics subsystem, has its own local level controller (called lower level controller) that are designed such that they follow exactly the command reference from a higher level controller. The higher level controller is an intelligent controller that makes decisions about how the lower level or local controllers should perform based on the status of fuel cell, energy storage device and external load demand. Linear analysis has been done for the design and development of the local controllers as appropriate. For the higher level controller, a finite state machine model is developed and implemented using stateflow and fuzzy logic toolboxes of matlab. Simulations are carried out for the integrated system. The simulation results verify that the controllers are robust in performance during the transient condition when the energy storage devices supplement fuel cells. The temperature and flow rates of the fuel and air are controlled as desired. The output from the designed fuel cell system is a regulated DC voltage, which verifies the overall

  5. Hydrogen storage systems based on magnesium hydride: from laboratory tests to fuel cell integration

    Science.gov (United States)

    de Rango, P.; Marty, P.; Fruchart, D.

    2016-02-01

    The paper reviews the state of the art of hydrogen storage systems based on magnesium hydride, emphasizing the role of thermal management, whose effectiveness depends on the effective thermal conductivity of the hydride, but also depends of other limiting factors such as wall contact resistance and convective exchanges with the heat transfer fluid. For daily cycles, the use of phase change material to store the heat of reaction appears to be the most effective solution. The integration with fuel cells (1 kWe proton exchange membrane fuel cell and solid oxide fuel cell) highlights the dynamic behaviour of these systems, which is related to the thermodynamic properties of MgH2. This allows for "self-adaptive" systems that do not require control of the hydrogen flow rate at the inlet of the fuel cell.

  6. Fluidic Logic Used in a Systems Approach to Enable Integrated Single-cell Functional Analysis

    Directory of Open Access Journals (Sweden)

    Naveen Ramalingam

    2016-09-01

    Full Text Available The study of single cells has evolved over the past several years to include expression and genomic analysis of an increasing number of single cells. Several studies have demonstrated wide-spread variation and heterogeneity within cell populations of similar phenotype. While the characterization of these populations will likely set the foundation for our understanding of genomic- and expression-based diversity, it will not be able to link the functional differences of a single cell to its underlying genomic structure and activity. Currently, it is difficult to perturb single cells in a controlled environment, monitor and measure the response due to perturbation, and link these response measurements to downstream genomic and transcriptomic analysis. In order to address this challenge, we developed a platform to integrate and miniaturize many of the experimental steps required to study single-cell function. The heart of this platform is an elastomer-based Integrated Fluidic Circuit (IFC that uses fluidic logic to select and sequester specific single cells based on a phenotypic trait for downstream experimentation. Experiments with sequestered cells that have been performed include on-chip culture, exposure to a variety of stimulants, and post-exposure image-based response analysis, followed by preparation of the mRNA transcriptome for massively parallel sequencing analysis. The flexible system embodies experimental design and execution that enable routine functional studies of single cells.

  7. Systems Biology of cancer: Moving toward the Integrative Study of the metabolic alterations in cancer cells.

    Directory of Open Access Journals (Sweden)

    Claudia Erika Hernández Patiño

    2013-01-01

    Full Text Available One of the main objectives in systems biology is to understand the biological mechanisms that give rise to the phenotype of a microorganism by using high-throughput technologies and genome-scale mathematical modeling. The computational modeling of genome-scale metabolic reconstructions is one systemic and quantitative strategy for characterizing the metabolic phenotype associated with human diseases and potentially for designing drugs with optimal clinical effects. The purpose of this short review is to describe how computational modeling, including the specific case of constraint-based modeling, can be used to explore, characterize and predict the metabolic capacities that distinguish the metabolic phenotype of cancer cell lines. As we show herein, this computational framework is far from a pure theoretical description, and to ensure proper biological interpretation, it is necessary to integrate high-throughput data and generate predictions for later experimental assessment. Hence, genome-scale modeling serves as a platform for the following: 1 the integration of data from high-throughput technologies, 2 the assessment of how metabolic activity is related to phenotype in cancer cell lines and 3 the design of new experiments to evaluate the outcomes of the in silico analysis. By combining the functions described above, we show that computational modeling is a useful methodology to construct an integrative, systemic and quantitative scheme for understanding the metabolic profiles of cancer cell lines, a first step to determine the metabolic mechanism by which cancer cells maintain and support their malignant phenotype in human tissues.

  8. Systems biology of cancer: moving toward the integrative study of the metabolic alterations in cancer cells.

    Science.gov (United States)

    Hernández Patiño, Claudia E; Jaime-Muñoz, Gustavo; Resendis-Antonio, Osbaldo

    2012-01-01

    One of the main objectives in systems biology is to understand the biological mechanisms that give rise to the phenotype of a microorganism by using high-throughput technologies (HTs) and genome-scale mathematical modeling. The computational modeling of genome-scale metabolic reconstructions is one systemic and quantitative strategy for characterizing the metabolic phenotype associated with human diseases and potentially for designing drugs with optimal clinical effects. The purpose of this short review is to describe how computational modeling, including the specific case of constraint-based modeling, can be used to explore, characterize, and predict the metabolic capacities that distinguish the metabolic phenotype of cancer cell lines. As we show herein, this computational framework is far from a pure theoretical description, and to ensure proper biological interpretation, it is necessary to integrate high-throughput data and generate predictions for later experimental assessment. Hence, genome-scale modeling serves as a platform for the following: (1) the integration of data from HTs, (2) the assessment of how metabolic activity is related to phenotype in cancer cell lines, and (3) the design of new experiments to evaluate the outcomes of the in silico analysis. By combining the functions described above, we show that computational modeling is a useful methodology to construct an integrative, systemic, and quantitative scheme for understanding the metabolic profiles of cancer cell lines, a first step to determine the metabolic mechanism by which cancer cells maintain and support their malignant phenotype in human tissues.

  9. System integration design in MEMS – A case study of micromachined load cell

    Indian Academy of Sciences (India)

    Shishir Kumar; K P Venkatesh; S Sam Baskar; S P Madhavi

    2009-08-01

    One of the critical issues in large scale commercial exploitation of MEMS technology is its system integration. In MEMS, a system design approach requires integration of varied and disparate subsystems with one of a kind interface. The physical scales as well as the magnitude of signals of various subsystems vary widely. Known and proven integration techniques often lead to considerable loss in advantages the tiny MEMS sensors have to offer. Therefore, it becomes imperative to think of the entire system at the outset, at least in terms of the concept design. Such design entails various aspects of the system ranging from selection of material, transduction mechanism, structural configuration, interface electronics, and packaging. One way of handling this problem is the system-in-package approach that uses optimized technology for each function using the concurrent hybrid engineering approach. The main strength of this design approach is the fast time to prototype development. In the present work, we pursue this approach for a MEMS load cell to complete the process of system integration for high capacity load sensing. The system includes; a micromachined sensing gauge, interface electronics and a packaging module representing a system-in-package ready for end characterization. The various subsystems are presented in a modular stacked form using hybrid technologies. The micromachined sensing subsystem works on principles of piezo-resistive sensing and is fabricated using CMOS compatible processes. The structural configuration of the sensing layer is designed to reduce the offset, temperature drift, and residual stress effects of the piezo-resistive sensor. ANSYS simulations are carried out to study the effect of substrate coupling on sensor structure and its sensitivity. The load cell system has built-in electronics for signal conditioning, processing, and communication, taking into consideration the issues associated with resolution of minimum detectable signal

  10. Analysis of a fuel cell on-site integrated energy system for a residential complex

    Science.gov (United States)

    Simons, S. N.; Maag, W. L.

    1979-01-01

    The energy use and costs of the on-site integrated energy system (OS/IES) which provides electric power from an on-site power plant and recovers heat that would normally be rejected to the environment is compared to a conventional system purchasing electricity from a utility and a phosphoric acid fuel cell powered system. The analysis showed that for a 500-unit apartment complex a fuel OS/IES would be about 10% more energy conservative in terms of total coal consumption than a diesel OS/IES system or a conventional system. The fuel cell OS/IES capital costs could be 30 to 55% greater than the diesel OS/IES capital costs for the same life cycle costs. The life cycle cost of a fuel cell OS/IES would be lower than that for a conventional system as long as the cost of electricity is greater than $0.05 to $0.065/kWh. An analysis of several parametric combinations of fuel cell power plant and state-of-art energy recovery systems and annual fuel requirement calculations for four locations were made. It was shown that OS/IES component choices are a major factor in fuel consumption, with the least efficient system using 25% more fuel than the most efficient. Central air conditioning and heat pumps result in minimum fuel consumption while individual air conditioning units increase it, and in general the fuel cell of highest electrical efficiency has the lowest fuel consumption.

  11. Further Improvement and System Integration of High Temperature Polymer Electrolyte Membrane Fuel Cells

    DEFF Research Database (Denmark)

    Li, Qingfeng; Jensen, Jens Oluf

    with these compatible subunits. The main goal of the project is a 2kWel HT-PEMFC stack operating in a temperature range of 150-200°C, with a single cell performance target of 0.7 A/cm² at a cell voltage around 0.6 V. The target durability is more than 5,000 hours. A hydrocarbon reformer and a catalytic burner...... are to be developed and integrated with the stack. The key issue of the project is development and improvement of the temperature-resistant polymer membranes with respect to durability, conductivity, mechanical and other properties. For this purpose, basic polymers will be first synthesized and optimized. Different...... routes to functionalize the polymers will be explored to increate proton conductivity. By the development of advanced materials, demonstration of the high temperature PEMFC stack and integration of such a system, FURIM is expected to sufficiently promote the commercialisation of the fuel cell technology...

  12. Catalyst development and systems analysis of methanol partial oxidation for the fuel processor - fuel cell integration

    Energy Technology Data Exchange (ETDEWEB)

    Newson, E.; Mizsey, P.; Hottinger, P.; Truong, T.B.; Roth, F. von; Schucan, Th.H. [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1999-08-01

    Methanol partial oxidation (pox) to produce hydrogen for mobile fuel cell applications has proved initially more successful than hydrocarbon pox. Recent results of catalyst screening and kinetic studies with methanol show that hydrogen production rates have reached 7000 litres/hour/(litre reactor volume) for the dry pox route and 12,000 litres/hour/(litre reactor volume) for wet pox. These rates are equivalent to 21 and 35 kW{sub th}/(litre reactor volume) respectively. The reaction engineering problems remain to be solved for dry pox due to the significant exotherm of the reaction (hot spots of 100-200{sup o}C), but wet pox is essentially isothermal in operation. Analyses of the integrated fuel processor - fuel cell systems show that two routes are available to satisfy the sensitivity of the fuel cell catalysts to carbon monoxide, i.e. a preferential oxidation reactor or a membrane separator. Targets for individual system components are evaluated for the base and best case systems for both routes to reach the combined 40% efficiency required for the integrated fuel processor - fuel cell system. (author) 2 figs., 1 tab., 3 refs.

  13. Study of component technologies for fuel cell on-site integrated energy systems

    Science.gov (United States)

    Lee, W. D.; Mathias, S.

    1980-01-01

    Heating, ventilation and air conditioning equipment are integrated with three types of fuel cells. System design and computer simulations are developed to utilize the thermal energy discharge of the fuel in the most cost effective manner. The fuel provides all of the electric needs and a loss of load probability analysis is used to ensure adequate power plant reliability. Equipment cost is estimated for each of the systems analyzed. A levelized annual cost reflecting owning and operating costs including the cost of money was used to select the most promising integrated system configurations. Cash flows are presented for the most promising 16 systems. Several systems for the 96 unit apartment complex (a retail store was also studied) were cost competitive with both gas and electric based conventional systems. Thermal storage is shown to be beneficial and the optimum absorption chiller sizing (waste heat recovery) in connection with electric chillers are developed. Battery storage was analyzed since the system is not electric grid connected. Advanced absorption chillers were analyzed as well. Recommendations covering financing, technical development, and policy issues are given to accelerate the commercialization of the fuel cell for on-site power generation in buildings.

  14. Dynamic modeling, experimental evaluation, optimal design and control of integrated fuel cell system and hybrid energy systems for building demands

    Science.gov (United States)

    Nguyen, Gia Luong Huu

    Fuel cells can produce electricity with high efficiency, low pollutants, and low noise. With the advent of fuel cell technologies, fuel cell systems have since been demonstrated as reliable power generators with power outputs from a few watts to a few megawatts. With proper equipment, fuel cell systems can produce heating and cooling, thus increased its overall efficiency. To increase the acceptance from electrical utilities and building owners, fuel cell systems must operate more dynamically and integrate well with renewable energy resources. This research studies the dynamic performance of fuel cells and the integration of fuel cells with other equipment in three levels: (i) the fuel cell stack operating on hydrogen and reformate gases, (ii) the fuel cell system consisting of a fuel reformer, a fuel cell stack, and a heat recovery unit, and (iii) the hybrid energy system consisting of photovoltaic panels, fuel cell system, and energy storage. In the first part, this research studied the steady-state and dynamic performance of a high temperature PEM fuel cell stack. Collaborators at Aalborg University (Aalborg, Denmark) conducted experiments on a high temperature PEM fuel cell short stack at steady-state and transients. Along with the experimental activities, this research developed a first-principles dynamic model of a fuel cell stack. The dynamic model developed in this research was compared to the experimental results when operating on different reformate concentrations. Finally, the dynamic performance of the fuel cell stack for a rapid increase and rapid decrease in power was evaluated. The dynamic model well predicted the performance of the well-performing cells in the experimental fuel cell stack. The second part of the research studied the dynamic response of a high temperature PEM fuel cell system consisting of a fuel reformer, a fuel cell stack, and a heat recovery unit with high thermal integration. After verifying the model performance with the

  15. Reporter Proteins in Whole-Cell Optical Bioreporter Detection Systems, Biosensor Integrations, and Biosensing Applications

    Science.gov (United States)

    Close, Dan M.; Ripp, Steven; Sayler, Gary S.

    2009-01-01

    Whole-cell, genetically modified bioreporters are designed to emit detectable signals in response to a target analyte or related group of analytes. When integrated with a transducer capable of measuring those signals, a biosensor results that acts as a self-contained analytical system useful in basic and applied environmental, medical, pharmacological, and agricultural sciences. Historically, these devices have focused on signaling proteins such as green fluorescent protein, aequorin, firefly luciferase, and/or bacterial luciferase. The biochemistry and genetic development of these sensor systems as well as the advantages, challenges, and common applications of each one will be discussed. PMID:22291559

  16. Reporter Proteins in Whole-Cell Optical Bioreporter Detection Systems, Biosensor Integrations, and Biosensing Applications

    Directory of Open Access Journals (Sweden)

    Gary S. Sayler

    2009-11-01

    Full Text Available Whole-cell, genetically modified bioreporters are designed to emit detectable signals in response to a target analyte or related group of analytes. When integrated with a transducer capable of measuring those signals, a biosensor results that acts as a self-contained analytical system useful in basic and applied environmental, medical, pharmacological, and agricultural sciences. Historically, these devices have focused on signaling proteins such as green fluorescent protein, aequorin, firefly luciferase, and/or bacterial luciferase. The biochemistry and genetic development of these sensor systems as well as the advantages, challenges, and common applications of each one will be discussed.

  17. Development of an Integrated Microfluidic Perfusion Cell Culture System for Real-Time Microscopic Observation of Biological Cells

    Directory of Open Access Journals (Sweden)

    Chih-Chin Oh-Yang

    2011-08-01

    Full Text Available This study reports an integrated microfluidic perfusion cell culture system consisting of a microfluidic cell culture chip, and an indium tin oxide (ITO glass-based microheater chip for micro-scale perfusion cell culture, and its real-time microscopic observation. The system features in maintaining both uniform, and stable chemical or thermal environments, and providing a backflow-free medium pumping, and a precise thermal control functions. In this work, the performance of the medium pumping scheme, and the ITO glass microheater were experimentally evaluated. Results show that the medium delivery mechanism was able to provide pumping rates ranging from 15.4 to 120.0 μL·min−1. In addition, numerical simulation and experimental evaluation were conducted to verify that the ITO glass microheater was capable of providing a spatially uniform thermal environment, and precise temperature control with a mild variation of ±0.3 °C. Furthermore, a perfusion cell culture was successfully demonstrated, showing the cultured cells were kept at high cell viability of 95 ± 2%. In the process, the cultured chondrocytes can be clearly visualized microscopically. As a whole, the proposed cell culture system has paved an alternative route to carry out real-time microscopic observation of biological cells in a simple, user-friendly, and low cost manner.

  18. Comparison of fuel-cell and diesel integrated energy systems and a conventional system for a 500-unit apartment

    Science.gov (United States)

    Simons, S. N.; Maag, W. L.

    1978-01-01

    The electrical and thermal energy utilization efficiencies of a 500 unit apartment complex are analyzed and compared for each of three energy supply systems. Two on-site integrated energy systems, one powered by diesel engines and the other by phosphoric-acid fuel cells were compared with a conventional system which uses purchased electricity and on-site boilers for heating. All fuels consumed on-site are clean, synthetic fuels (distillate fuel oil or pipeline quality gas) derived from coal. Purchased electricity was generated from coal at a central station utility. The relative energy consumption and economics of the three systems are analyzed and compared.

  19. An efficient strategy for cell-based antibody library selection using an integrated vector system

    Directory of Open Access Journals (Sweden)

    Yoon Hyerim

    2012-09-01

    Full Text Available Abstract Background Cell panning of phage-displayed antibody library is a powerful tool for the development of therapeutic and imaging agents since disease-related cell surface proteins in native complex conformation can be directly targeted. Here, we employed a strategy taking advantage of an integrated vector system which allows rapid conversion of scFv-displaying phage into scFv-Fc format for efficient cell-based scFv library selection on a tetraspanin protein, CD9. Results A mouse scFv library constructed by using a phagemid vector, pDR-D1 was subjected to cell panning against stable CD9 transfectant, and the scFv repertoire from the enriched phage pool was directly transferred to a mammalian cassette vector, pDR-OriP-Fc1. The resulting constructs enabled transient expression of enough amounts of scFv-Fcs in HEK293E cells, and flow cytometric screening of binders for CD9 transfectant could be performed simply by using the culture supernatants. All three clones selected from the screening showed correct CD9-specificity. They could immunoprecipitate CD9 molecules out of the transfectant cell lysate and correctly stain endogenous CD9 expression on cancer cell membrane. Furthermore, competition assay with a known anti-CD9 monoclonal antibody (mAb suggested that the binding epitopes of some of them overlap with that of the mAb which resides within the large extracellular loop of CD9. Conclusions This study demonstrates that scFv-Fc from mammalian transient expression can be chosen as a reliable format for rapid screening and validation in cell-based scFv library selection, and the strategy described here will be applicable to efficient discovery of antibodies to diverse cell-surface targets.

  20. Investigating the Integration of a Solid Oxide Fuel Cell and a Gas Turbine System with Coal Gasification Technologies

    Science.gov (United States)

    2001-09-01

    conceptually integrate the hybrid power system with existing and imminent coal gasification technologies. The gasification technologies include the Kellogg...Brown Root (KBR) Transport Reactor and entrained coal gasification . Parametric studies will be performed wherein pertinent fuel cell stack process...dependent variables of interest. Coal gasification data and a proven SOFC model will be used to test the theoretical integration. Feasibility and

  1. Further Improvement and System Integration of High Temperature Polymer Electrolyte Membrane Fuel Cells

    DEFF Research Database (Denmark)

    Jensen, Jens Oluf; Li, Qingfeng

    and power management system, that are compatible with the HT-PEMFC; and (3) integration of the HT-PEMFC stack with these compatible subunits. The main goal of the project is a 2kWel HT-PEMFC stack operating in a temperature range of 120-220°C, with a single cell performance target of 0.7 A/cm² at a cell...... voltage around 0.6 V. The target durability is more than 5,000 hours. A hydrocarbon reformer and a catalytic burner are to be developed and integrated with the stack. The key issue of the project is development and improvement of the temperature-resistant polymer membranes with respect to durability......, conductivity, mechanical and other properties. For this purpose, basic polymers will be first synthesized and optimized. Different routes to functionalize the polymers will be explored to increate proton conductivity. By the development of advanced materials, demonstration of the high temperature PEMFC stack...

  2. Tactical Systems Integration Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — The Tactical Systems Integration Laboratory is used to design and integrate computer hardware and software and related electronic subsystems for tactical vehicles....

  3. Geometric Integration Of The Vlasov-Maxwell System With A Variational Particle-in-cell Scheme

    Energy Technology Data Exchange (ETDEWEB)

    J. Squire, H. Qin and W.M. Tang

    2012-03-27

    A fully variational, unstructured, electromagnetic particle-in-cell integrator is developed for integration of the Vlasov-Maxwell equations. Using the formalism of Discrete Exterior Calculus [1], the field solver, interpolation scheme and particle advance algorithm are derived through minimization of a single discrete field theory action. As a consequence of ensuring that the action is invariant under discrete electromagnetic gauge transformations, the integrator exactly conserves Gauss's law.

  4. Geometric integration of the Vlasov-Maxwell system with a variational particle-in-cell scheme

    Energy Technology Data Exchange (ETDEWEB)

    Squire, J.; Tang, W. M. [Plasma Physics Laboratory, Princeton University, Princeton, New Jersey 08543 (United States); Qin, H. [Plasma Physics Laboratory, Princeton University, Princeton, New Jersey 08543 (United States); Department of Modern Physics, University of Science and Technology of China, Hefei, Anhui 230026 (China)

    2012-08-15

    A fully variational, unstructured, electromagnetic particle-in-cell integrator is developed for integration of the Vlasov-Maxwell equations. Using the formalism of discrete exterior calculus [Desbrun et al., e-print arXiv:math/0508341 (2005)], the field solver, interpolation scheme, and particle advance algorithm are derived through minimization of a single discrete field theory action. As a consequence of ensuring that the action is invariant under discrete electromagnetic gauge transformations, the integrator exactly conserves Gauss's law.

  5. Geometric integration of the Vlasov-Maxwell system with a variational particle-in-cell scheme

    OpenAIRE

    2014-01-01

    A fully variational, unstructured, electromagnetic particle-in-cell integrator is developed for integration of the Vlasov-Maxwell equations. Using the formalism of Discrete Exterior Calculus, the field solver, interpolation scheme and particle advance algorithm are derived through minimization of a single discrete field theory action. As a consequence of ensuring that the action is invariant under discrete electromagnetic gauge transformations, the integrator exactly conserves Gauss's law.

  6. Feedback control system simulator for the control of biological cells in microfluidic cross slots and integrated microfluidic systems.

    Science.gov (United States)

    Curtis, Michael D; Sheard, Gregory J; Fouras, Andreas

    2011-07-21

    Control systems for lab on chip devices require careful characterisation and design for optimal performance. Traditionally, this involves either extremely computationally expensive simulations or lengthy iteration of laboratory experiments, prototype design, and manufacture. In this paper, an efficient control simulation technique, valid for typical microchannels, Computed Interpolated Flow Hydrodynamics (CIFH), is described that is over 500 times faster than conventional time integration techniques. CIFH is a hybrid approach, utilising a combination of pre-computed flows and hydrodynamic equations and allows the efficient simulation of dynamic control systems for the transport of cells through micro-fluidic devices. The speed-ups achieved by using pre-computed CFD solutions mapped to an n-dimensional control parameter space, significantly accelerate the evaluation and improvement of control strategies and chip design. Here, control strategies for a naturally unstable device geometry, the microfluidic cross-slot, have been simulated and optimal parameters have been found for proposed devices capable of trapping and sorting cells.

  7. Policy schemes, operational strategies and system integration of residential co-generation fuel cells

    DEFF Research Database (Denmark)

    Hansen, Lise-Lotte Pade; Schröder, Sascha Thorsten; Münster, Marie

    2013-01-01

    This study presents a holistic approach for the commercialisation of fuel cells for stationary applications. We focus our analyses on microCHP based on SOFC units fired with natural gas. We analyse the interaction of operational strategies under different ownership arrangements, required support...... levels and system integration aspects. The operational strategies, support mechanisms and ownership arrangements have been identified through actor analysis involving experts from Denmark, France and Portugal. With regard to operational strategies, the actor analyses led us to distinguishing between...... a heat-driven strategy, with and without time-differentiated tariffs, and an electricity price driven strategy for the operation as a virtual power plant. The corresponding support schemes identified cover feed-in tariffs, net metering and feed-in premiums. Additionally, the interplay of the micro...

  8. Real-time monitoring of cellular dynamics using a microfluidic cell culture system with integrated electrode array and potentiostat

    DEFF Research Database (Denmark)

    Zor, Kinga; Vergani, M.; Heiskanen, Arto

    2011-01-01

    A versatile microfluidic, multichamber cell culture and analysis system with an integrated electrode array and potentiostat suitable for electrochemical detection and microscopic imaging is presented in this paper. The system, which allows on-line electrode cleaning and modification, was develope...

  9. DOE Hydrogen, Fuel Cells and Infrastructure Technologies Program Integrated Hydrogen Production, Purification and Compression System

    Energy Technology Data Exchange (ETDEWEB)

    Tamhankar, Satish; Gulamhusein, Ali; Boyd, Tony; DaCosta, David; Golben, Mark

    2011-06-30

    The project was started in April 2005 with the objective to meet the DOE target of delivered hydrogen of <$1.50/gge, which was later revised by DOE to $2-$3/gge range for hydrogen to be competitive with gasoline as a fuel for vehicles. For small, on-site hydrogen plants being evaluated at the time for refueling stations (the 'forecourt'), it was determined that capital cost is the main contributor to the high cost of delivered hydrogen. The concept of this project was to reduce the cost by combining unit operations for the entire generation, purification, and compression system (refer to Figure 1). To accomplish this, the Fluid Bed Membrane Reactor (FBMR) developed by MRT was used. The FBMR has hydrogen selective, palladium-alloy membrane modules immersed in the reformer vessel, thereby directly producing high purity hydrogen in a single step. The continuous removal of pure hydrogen from the reformer pushes the equilibrium 'forward', thereby maximizing the productivity with an associated reduction in the cost of product hydrogen. Additional gains were envisaged by the integration of the novel Metal Hydride Hydrogen Compressor (MHC) developed by Ergenics, which compresses hydrogen from 0.5 bar (7 psia) to 350 bar (5,076 psia) or higher in a single unit using thermal energy. Excess energy from the reformer provides up to 25% of the power used for driving the hydride compressor so that system integration improved efficiency. Hydrogen from the membrane reformer is of very high, fuel cell vehicle (FCV) quality (purity over 99.99%), eliminating the need for a separate purification step. The hydride compressor maintains hydrogen purity because it does not have dynamic seals or lubricating oil. The project team set out to integrate the membrane reformer developed by MRT and the hydride compression system developed by Ergenics in a single package. This was expected to result in lower cost and higher efficiency compared to conventional hydrogen production

  10. Integrated Microchannel Reformer/Hydrogen Purifier for Fuel Cell Power Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Makel Engineering, Inc. (MEI) and Colorado School of Mines (CSM) propose to develop an integrated hydrogen generator and purifier system for conversion of in-situ...

  11. Geometric integration of the Vlasov-Maxwell system with a variational particle-in-cell scheme

    Science.gov (United States)

    Squire, Jonathan; Qin, Hong; Tang, William

    2012-10-01

    A fully variational, unstructured, electromagnetic particle-in-cell integrator is developed for integration of the Vlasov-Maxwell equations. Using the formalism of Discrete Exterior Calculus [1], the field solver, interpolation scheme and particle advance algorithm are derived through minimization of a single discrete field theory action. As a consequence of ensuring that the action is invariant under discrete electromagnetic gauge transformations, the integrator exactly conserves Gauss's law. This work was supported by USDOE Contract DE-AC02-09CH11466.[4pt] [1] M. Desbrun, A. N. Hirani, M. Leok, and J. E. Marsden, (2005), arXiv:math/0508341

  12. Intelligent test integration system

    Science.gov (United States)

    Sztipanovits, J.; Padalkar, S.; Rodriguez-Moscoso, J.; Kawamura, K.; Purves, B.; Williams, R.; Biglari, H.

    1988-01-01

    A new test technology is described which was developed for space system integration. The ultimate purpose of the system is to support the automatic generation of test systems in real time, distributed computing environments. The Intelligent Test Integration System (ITIS) is a knowledge based layer above the traditional test system components which can generate complex test configurations from the specification of test scenarios.

  13. Integrated library systems.

    Science.gov (United States)

    Goldstein, C M

    1983-07-01

    The development of integrated library systems is discussed. The four major discussion points are (1) initial efforts; (2) network resources; (3) minicomputer-based systems; and (4) beyond library automation. Four existing systems are cited as examples of current systems.

  14. Integrated Systems for Rapid Point of Care (PoC) Blood Cell Analysis

    NARCIS (Netherlands)

    Van Berkel, C.; Gwyer, J.D.; Deane, S.; Hollis, V.; Holloway, J.; Green, N.; Morgan, H.M.

    2011-01-01

    Counting the different subpopulations of cells in a fingerprick of human blood is important for a number of clinical Point of Care applications. It is a challenge to demonstrate the integration of sample preparation and detection techniques in a single platform. In this article we review the applica

  15. System and method for integration of renewable energy and fuel cell for the production of electricity and hydrogen

    NARCIS (Netherlands)

    Hemmes, K.

    2007-01-01

    The invention relates to a system and method for integrating renewable energy and a fuel cell for the production of electricity and hydrogen, wherein this comprises the use of renewable energy as fluctuating energy source for the production of electricity and also comprises the use of at least one f

  16. Progress in the integration of Test Blanket Systems in ITER equatorial port cells and in the interfaces definition

    Energy Technology Data Exchange (ETDEWEB)

    Pascal, R., E-mail: romain.pascal@iter.org [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Beloglazov, S.; Bonagiri, S. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Commin, L. [CEA, IRFM, Cadarache (France); Cortes, P.; Giancarli, L.M.; Gliss, C.; Iseli, M.; Lanza, R.; Levesy, B.; Martins, J.-P. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Neviere, J.-C. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Comex-Nucleaire, 13115 Saint Paul Lez Durance (France); Patisson, L.; Plutino, D.; Shu, W. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Swami, H.L. [Institute for Plasma Research, Bhat, Gandhinagar 382428 (India)

    2012-08-15

    Highlights: Black-Right-Pointing-Pointer The design integration of two test blanket systems in ITER port cell is addressed. Black-Right-Pointing-Pointer Definition of interfaces of TBSs with building and other ITER systems is done. Black-Right-Pointing-Pointer Designs of pipe forest, bioshield plug and ancillary equipment unit are described. Black-Right-Pointing-Pointer The maintenance of the two test blanket systems in ITER port cell is considered. Black-Right-Pointing-Pointer The management of the heat and tritium releases in the TBM port cell is described. - Abstract: In the framework of the TBM Program, three ITER vacuum vessel equatorial ports (no. 16, no. 18 and no. 02) have been allocated for the testing of up to six mock-ups of six different DEMO tritium breeding blankets. Each one is called a Test Blanket System (TBS). A TBS consists mainly of the Test Blanket Module (TBM), the in-vessel component facing the plasma, and several ancillary systems, in particular the cooling system and the tritium extraction system. Each port accommodates two TBMs and therefore the two TBSs have to share the corresponding port cell. This paper deals with the design integration aspects of the two TBSs in each port cell performed at ITER Organization (IO) with the corresponding definition of interfaces with other ITER systems. The performed activities have raised several issues that are discussed in the paper and for which design solutions are proposed.

  17. Dynamic model of a micro-tubular solid oxide fuel cell stack including an integrated cooling system

    Science.gov (United States)

    Hering, Martin; Brouwer, Jacob; Winkler, Wolfgang

    2017-02-01

    A novel dynamic micro-tubular solid oxide fuel cell (MT-SOFC) and stack model including an integrated cooling system is developed using a quasi three-dimensional, spatially resolved, transient thermodynamic, physical and electrochemical model that accounts for the complex geometrical relations between the cells and cooling-tubes. The modeling approach includes a simplified tubular geometry and stack design including an integrated cooling structure, detailed pressure drop and gas property calculations, the electrical and physical constraints of the stack design that determine the current, as well as control strategies for the temperature. Moreover, an advanced heat transfer balance with detailed radiative heat transfer between the cells and the integrated cooling-tubes, convective heat transfer between the gas flows and the surrounding structures and conductive heat transfer between the solid structures inside of the stack, is included. The detailed model can be used as a design basis for the novel MT-SOFC stack assembly including an integrated cooling system, as well as for the development of a dynamic system control strategy. The evaluated best-case design achieves very high electrical efficiency between around 75 and 55% in the entire power density range between 50 and 550 mW /cm2 due to the novel stack design comprising an integrated cooling structure.

  18. System integration report

    Science.gov (United States)

    Badler, N. I.; Korein, J. D.; Meyer, C.; Manoochehri, K.; Rovins, J.; Beale, J.; Barr, B.

    1985-01-01

    Several areas that arise from the system integration issue were examined. Intersystem analysis is discussed as it relates to software development, shared data bases and interfaces between TEMPUS and PLAID, shaded graphics rendering systems, object design (BUILD), the TEMPUS animation system, anthropometric lab integration, ongoing TEMPUS support and maintenance, and the impact of UNIX and local workstations on the OSDS environment.

  19. Integrated modeling and control of a PEM fuel cell power system with a PWM DC/DC converter

    Energy Technology Data Exchange (ETDEWEB)

    Choe, Song-Yul; Ahn, Jong-Woo [Mechanical Engineering Department, Auburn University, Auburn, AL 36848 (United States); Lee, Jung-Gi [Electrical Engineering Department, Pohang University of Science and Technology, Pohang (Korea); Baek, Soo-Hyun [Electrical Engineering Department, Dong-guk University, Seoul (Korea)

    2007-02-10

    A fuel cell powered system is regarded as a high current and low voltage source. To boost the output voltage of a fuel cell, a DC/DC converter is employed. Since these two systems show different dynamics, they need to be coordinated to meet the demand of a load. This paper proposes models for the two systems with associated controls, which take into account a PEM fuel cell stack with air supply and thermal systems, and a PWM DC/DC converter. The integrated simulation facilitates optimization of the power control strategy, and analyses of interrelated effects between the electric load and the temperature of cell components. In addition, the results show that the proposed power control can coordinate the two sources with improved dynamics and efficiency at a given dynamic load. (author)

  20. Integrated microchemical systems for fuel processing in micro fuel cell applications

    Science.gov (United States)

    Pattekar, Ashish V.

    Rapid advances in microelectronics technology over the last decade have led to the search for novel applications of miniaturization to all aspects of engineering. Microreaction engineering, which involves the development of miniature reactors on microchips for novel applications, has been a key area of interest in this quest for miniaturization. The idea of a fully integrated microplant with embedded control electronics, sensors and actuators on a single silicon chip has been gaining increasing acceptance as significant progress is being made in this area. The aim of this project has been to demonstrate a working microreaction system for hydrogen delivery to miniature proton exchange membrane (PEM) fuel cells through the catalytic steam reforming of methanol. The complete reformer - fuel cell unit is proposed as an alternative to conventional portable sources of electricity such as batteries due to its ability to provide an uninterrupted supply of electricity as long as a supply of methanol and water can be provided. This technology also offers significantly higher energy storage densities, which translates into less frequent 'recharging' through the refilling of methanol fuel. Various aspects of the design of a miniature methanol reformer on a silicon substrate are discussed with a focus on the theoretical understanding of microreactor operation and optimum utilization of the semiconductor-processing techniques used for fabricating the devices. Three prototype microreactor designs have been successfully fabricated and tested. Issues related to microchannel capping, on-chip heating and temperature sensing, introduction and trapping of catalyst particles in microchannels, microfluidic interfacing, pressure drop reduction, and thermal insulation have been addressed. Details regarding modeling and simulation of the designs to provide an insight into the working of the microreactor are presented along with a description of the microfabrication steps followed to

  1. Further Improvement and System Integration of High Temperature Polymer Electrolyte Membrane Fuel Cells

    DEFF Research Database (Denmark)

    Li, Qingfeng; Jensen, Jens Oluf

    ) integration of the HT-PEMFC stack with these compatible subunits. The main goal of the project is a 2kWel HT-PEMFC stack operating in a temperature range of 150-200°C, with a single cell performance target of 0.7 A/cm² at a cell voltage around 0.6 V. The target durability is more than 5,000 hours....... A hydrocarbon reformer and a catalytic burner are to be developed and integrated with the stack. The key issue of the project is development and improvement of the temperature-resistant polymer membranes with respect to durability, conductivity, mechanical and other properties. For this purpose, basic polymers...... will be first synthesized and optimized. Different routes to functionalize the polymers will be explored to increate proton conductivity....

  2. An integrated approach for the cell formation and layout design in cellular manufacturing systems

    NARCIS (Netherlands)

    Javadi, Babak; Jolai, Fariborz; Slomp, Jannes; Rabbani, Masoud; Tavakkoli-Moghaddam, Reza

    2013-01-01

    In this paper, a comprehensive model is presented for cell formation and layout design in cellular manufacturing systems (CMS). The proposed model incorporates an extensive coverage of important operational features and especially layout design aspects to determine optimal cell configuration and Int

  3. Comparative study of PEM fuel cell models for integration in propulsion systems of urban public transport

    Energy Technology Data Exchange (ETDEWEB)

    Garcia, P.; Fernandez, L.M.; Garcia, C.A. [Department of Electrical Engineering, University of Cadiz, EPS Algeciras, Avda. Ramon Puyol, s/n. 11202 Algeciras (Cadiz) (Spain); Jurado, F. [Department of Electrical Engineering, University of Jaen, EPS Linares, C/ Alfonso X, n 28. 23700 Linares (Jaen) (Spain)

    2010-12-15

    Steady state and dynamic simulations are performed in order to compare the models. Considering the external response of FC system integrated in the tramway hybrid system, both reduced models show similar results with an important reduction of computation time with respect to the complete model. However, the reduced model 1 shows better results than the reduced model 2 when representing the internal behaviour of FC system, so that this model is considered the most appropriate for propulsion system applications. (Copyright copyright 2010 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  4. Integrated Reporting Information System -

    Data.gov (United States)

    Department of Transportation — The Integrated Reporting Information System (IRIS) is a flexible and scalable web-based system that supports post operational analysis and evaluation of the National...

  5. Systems Integration (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2011-10-01

    The Systems Integration (SI) subprogram works closely with industry, universities, and the national laboratories to overcome technical barriers to the large-scale deployment of solar technologies. To support these goals, the subprogram invests primarily in four areas: grid integration, technology validation, solar resource assessment, and balance of system development.

  6. Systems Integration (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    DOE Solar Energy Technologies Program

    2011-10-13

    The Systems Integration (SI) subprogram works closely with industry, universities, and the national laboratories to overcome technical barriers to the large-scale deployment of solar technologies. To support these goals, the subprogram invests primarily in four areas: grid integration, technology validation, solar resource assessment, and balance of system development.

  7. Acid Gas Removal by Customized Sorbents for Integrated Gasification Fuel Cell Systems

    Energy Technology Data Exchange (ETDEWEB)

    Kapfenberger, J.; Sohnemann, J.; Schleitzer, D.; Loewen, A.

    2002-09-20

    In order to reduce exergy losses, gas cleaning at high temperatures is favored in IGFC systems. As shown by thermodynamic data, separation efficiencies of common sorbents decrease with increasing temperature. Therefore, acid gas removal systems have to be developed for IGFC applications considering sorbent capacity, operation temperature, gasification feedstock composition and fuel cell threshold values.

  8. Micro reactor integrated μ-PEM fuel cell system: a feed connector and flow field free approach

    Science.gov (United States)

    Balakrishnan, A.; Mueller, C.; Reinecke, H.

    2013-12-01

    A system level microreactor concept for hydrogen generation with Sodium Borohydride (NaBH4) is demonstrated. The uniqueness of the system is the transport and distribution feature of fuel (hydrogen) to the anode of the fuel cell without any external feed connectors and flow fields. The approach here is to use palladium film instead of feed connectors and the flow fields; palladium's property to adsorb and desorb the hydrogen at ambient and elevated condition. The proof of concept is demonstrated with a polymethyl methacrylate (PMMA) based complete system integration which includes microreactor, palladium transport layer and the self-breathing polymer electrolyte membrane (PEM) fuel cell. The hydrolysis of NaBH4 was carried out in the presence of platinum supported by nickel (NiPt). The prototype functionality is tested with NaBH4 chemical hydride. The characterization of the integrated palladium layer and fuel cell is tested with constant and switching load. The presented integrated fuel cell is observed to have a maximum power output and current of 60 mW and 280 mA respectively.

  9. Optimization of Streptomyces bacteriophage phi C31 integrase system to prevent post integrative gene silencing in pulmonary type II cells.

    Science.gov (United States)

    Aneja, Manish Kumar; Geiger, Johannes; Imker, Rabea; Uzgun, Senta; Kormann, Michael; Hasenpusch, Guenther; Maucksch, Christof; Rudolph, Carsten

    2009-12-31

    phi C31 integrase has emerged as a potent tool for achieving long-term gene expression in different tissues. The present study aimed at optimizing elements of phi C31 integrase system for alveolar type II cells. Luciferase and beta-galactosidase activities were measured at different time points post transfection. 5-Aza-2'deoxycytidine (AZA) and trichostatin A (TSA) were used to inhibit DNA methyltransferase and histone deacetylase complex (HDAC) respectively. In A549 cells, expression of the integrase using a CMV promoter resulted in highest integrase activity, whereas in MLE12 cells, both CAG and CMV promoter were equally effective. Effect of polyA site was observed only in A549 cells, where replacement of SV40 polyA by bovine growth hormone (BGH) polyA site resulted in an enhancement of integrase activity. Addition of a C-terminal SV40 nuclear localization signal (NLS) did not result in any significant increase in integrase activity. Long-term expression studies with AZA and TSA, provided evidence for post-integrative gene silencing. In MLE12 cells, both DNA methylases and HDACs played a significant role in silencing, whereas in A549 cells, it could be attributed majorly to HDAC activity. Donor plasmids comprising cellular promoters ubiquitin B (UBB), ubiquitin C (UCC) and elongation factor 1 alpha (EF1 alpha) in an improved backbone prevented post-integrative gene silencing. In contrast to A549 and MLE12 cells, no silencing could be observed in human bronchial epithelial cells, BEAS-2B. Donor plasmid coding for murine erythropoietin under the EF1 alpha promoter when combined with phi C31 integrase resulted in higher long-term erythropoietin expression and subsequently higher hematocrit levels in mice after intravenous delivery to the lungs. These results provide evidence for cell specific post integrative gene silencing with C31 integrase and demonstrate the pivotal role of donor plasmid in long-term expression attained with this system.

  10. Integrative systems and synthetic biology of cell-matrix adhesion sites.

    Science.gov (United States)

    Zamir, Eli

    2016-09-02

    The complexity of cell-matrix adhesion convolves its roles in the development and functioning of multicellular organisms and their evolutionary tinkering. Cell-matrix adhesion is mediated by sites along the plasma membrane that anchor the actin cytoskeleton to the matrix via a large number of proteins, collectively called the integrin adhesome. Fundamental challenges for understanding how cell-matrix adhesion sites assemble and function arise from their multi-functionality, rapid dynamics, large number of components and molecular diversity. Systems biology faces these challenges in its strive to understand how the integrin adhesome gives rise to functional adhesion sites. Synthetic biology enables engineering intracellular modules and circuits with properties of interest. In this review I discuss some of the fundamental questions in systems biology of cell-matrix adhesion and how synthetic biology can help addressing them.

  11. Effectiveness of heat-integrated methanol steam reformer and polymer electrolyte membrane fuel cell stack systems for portable applications

    Science.gov (United States)

    Lotrič, A.; Sekavčnik, M.; Hočevar, S.

    2014-12-01

    Efficiently combining proton exchange membrane fuel cell (PEMFC) stack with methanol steam reformer (MSR) into a small portable system is still quite a topical issue. Using methanol as a fuel in PEMFC stack includes a series of chemical processes where each proceeds at a unique temperature. In a combined MSR-PEMFC-stack system with integrated auxiliary fuel processors (vaporizer, catalytic combustor, etc.) the processes are both endothermic and exothermic hence their proper thermal integration can help raising the system efficiency. A concept of such fully integrated and compact system is proposed in this study. Three separate systems are designed based on different PEMFC stacks and MSR. Low-temperature (LT) and conventional high-temperature (cHT) PEMFC stack characteristics are based on available data from suppliers. Also, a novel high-temperature (nHT) PEMFC stack is proposed because its operating temperature coincides with that of MSR. A comparative study of modelled systems is performed using a mass and energy balances zero-dimensional model, which is interdependently coupled to a physical model based on finite element method (FEM). The results indicate that a system with nHT PEMFC stack is feasible and has the potential to reach higher system efficiencies than systems with LT or cHT PEMFC stacks.

  12. An integrated environmental perfusion chamber and heating system for long-term, high resolution imaging of living cells.

    Science.gov (United States)

    Hing, W A; Poole, C A; Jensen, C G; Watson, M

    2000-08-01

    This communication presents the design and application of an integrated environmental perfusion chamber and stage heating blanket suitable for time-lapse video microscopy of living cells. The system consists of two independently regulated components: a perfusion chamber suitable for the maintenance of cell viability and the variable delivery of environmental factors, and a separate heating blanket to control the temperature of the microscope stage and limit thermal conduction from the perfusion chamber. Two contrasting experiments are presented to demonstrate the versatility of the system. One long-term sequence illustrates the behaviour of cells exposed to ceramic fibres. The other shows the shrinking response of cultured articular cartilage chondrons under dynamic hyper-osmotic conditions designed to simulate joint loading. The chamber is simple in design, economical to produce and permits long-term examination of dynamic cellular behaviour while satisfying the fundamental requirements for the maintenance of environmental factors that influence cell viability.

  13. Function integrated track system

    OpenAIRE

    Hohnecker, Eberhard

    2010-01-01

    The paper discusses a function integrated track system that focuses on the reduction of acoustic emissions from railway lines. It is shown that the combination of an embedded rail system (ERS), a sound absorbing track surface, and an integrated mini sound barrier has significant acoustic advantages compared to a standard ballast superstructure. The acoustic advantages of an embedded rail system are particularly pronounced in the case of railway bridges. Finally, it is shown that a...

  14. Develop and test fuel cell powered on-site integrated total energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Kaufman, A.; Werth, J.

    1988-12-01

    This report describes the design, fabrication and testing of a 25kW phosphoric acid fuel cell system aimed at stationary applications, and the technology development underlying that system. The 25kW fuel cell ran at rated power in both the open and closed loop mode in the summer of 1988. Problems encountered and solved include acid replenishment leakage, gas cross-leakage and edge-leakage in bipolar plates, corrosion of metallic cooling plates and current collectors, cooling groove depth variations, coolant connection leaks, etc. 84 figs., 7 tabs.

  15. Integrated management systems

    CERN Document Server

    Bugdol, Marek

    2015-01-01

    Examining the challenges of integrated management, this book explores the importance and potential benefits of using an integrated approach as a cross-functional concept of management. It covers not only standardized management systems (e.g. International Organization for Standardization), but also models of self-assessment, as well as different types of integration. Furthermore, it demonstrates how processes and systems can be integrated, and how management efficiency can be increased. The major part of this book focuses on management concepts which use integration as a key tool of management processes (e.g. the systematic approach, supply chain management, virtual and network organizations, processes management and total quality management). Case studies, illustrations, and tables are also provided to exemplify and illuminate the content, as well as examples of successful and failed integrations. Providing a particularly useful resource to managers and specialists involved in the improvement of organization...

  16. Integration of reusable systems

    CERN Document Server

    Rubin, Stuart

    2014-01-01

    Software reuse and integration has been described as the process of creating software systems from existing software rather than building software systems from scratch. Whereas reuse solely deals with the artifacts creation, integration focuses on how reusable artifacts interact with the already existing parts of the specified transformation. Currently, most reuse research focuses on creating and integrating adaptable components at development or at compile time. However, with the emergence of ubiquitous computing, reuse technologies that can support adaptation and reconfiguration of architectures and components at runtime are in demand. This edited book includes 15 high quality research papers written by experts in information reuse and integration to cover the most recent advances in the field. These papers are extended versions of the best papers which were presented at IEEE International Conference on Information Reuse and Integration and IEEE International Workshop on Formal Methods Integration, which wa...

  17. DNA Delivery and Genomic Integration into Mammalian Target Cells through Type IV A and B Secretion Systems of Human Pathogens

    Directory of Open Access Journals (Sweden)

    Dolores L. Guzmán-Herrador

    2017-08-01

    Full Text Available We explore the potential of bacterial secretion systems as tools for genomic modification of human cells. We previously showed that foreign DNA can be introduced into human cells through the Type IV A secretion system of the human pathogen Bartonella henselae. Moreover, the DNA is delivered covalently attached to the conjugative relaxase TrwC, which promotes its integration into the recipient genome. In this work, we report that this tool can be adapted to other target cells by using different relaxases and secretion systems. The promiscuous relaxase MobA from plasmid RSF1010 can be used to deliver DNA into human cells with higher efficiency than TrwC. MobA also promotes DNA integration, albeit at lower rates than TrwC. Notably, we report that DNA transfer to human cells can also take place through the Type IV secretion system of two intracellular human pathogens, Legionella pneumophila and Coxiella burnetii, which code for a distantly related Dot/Icm Type IV B secretion system. This suggests that DNA transfer could be an intrinsic ability of this family of secretion systems, expanding the range of target human cells. Further analysis of the DNA transfer process showed that recruitment of MobA by Dot/Icm was dependent on the IcmSW chaperone, which may explain the higher DNA transfer rates obtained. Finally, we observed that the presence of MobA negatively affected the intracellular replication of C. burnetii, suggesting an interference with Dot/Icm translocation of virulence factors.

  18. Architectural constraints are a major factor reducing path integration accuracy in the rat head direction cell system

    Directory of Open Access Journals (Sweden)

    Hector James Ingram Page

    2015-02-01

    Full Text Available Head direction cells fire to signal the direction in which an animal's head is pointing. They are able to track head direction using only internally-derived information (path integration. In this simulation study we investigate the factors that affect path integration accuracy. Specifically, two major limiting factors are identified: rise time, the time after stimulation it takes for a neuron to start firing, and the presence of symmetric non-offset within-layer recurrent collateral connectivity. On the basis of the latter, the important prediction is made that head direction cell regions directly involved in path integration will not contain this type of connectivity; giving a theoretical explanation for architectural observations. Increased neuronal rise time is found to slow path integration, and the slowing effect for a given rise time is found to be more severe in the context of short conduction delays. Further work is suggested on the basis of our findings, which represent a valuable contribution to understanding of the head direction cell system.

  19. Systems Integration Fact Sheet

    Energy Technology Data Exchange (ETDEWEB)

    None

    2016-06-01

    This fact sheet is an overview of the Systems Integration subprogram at the U.S. Department of Energy SunShot Initiative. The Systems Integration subprogram enables the widespread deployment of safe, reliable, and cost-effective solar energy technologies by addressing the associated technical and non-technical challenges. These include timely and cost-effective interconnection procedures, optimal system planning, accurate prediction of solar resources, monitoring and control of solar power, maintaining grid reliability and stability, and many more. To address the challenges associated with interconnecting and integrating hundreds of gigawatts of solar power onto the electricity grid, the Systems Integration program funds research, development, and demonstration projects in four broad, interrelated focus areas: grid performance and reliability, dispatchability, power electronics, and communications.

  20. Integrated inventory information system

    Digital Repository Service at National Institute of Oceanography (India)

    Sarupria, J.S.; Kunte, P.D.

    The nature of oceanographic data and the management of inventory level information are described in Integrated Inventory Information System (IIIS). It is shown how a ROSCOPO (report on observations/samples collected during oceanographic programme...

  1. Design and Optimization of an Integrated Biomass Gasification and Solid Oxide Fuel Cell System

    DEFF Research Database (Denmark)

    Bang-Møller, Christian

    . The work deals with the coupling of thermal biomass gasification and solid oxide fuel cells (SOFCs), and specific focus is kept on exploring the potential performance of hybrid CHP systems based on the novel two-stage gasification concept and SOFCs. The two-stage gasification concept is developed......Development of sustainable power plants has gained focus in the recent years and utilization of biomass resources are seen as a pathway towards a sustainable combined heat and power (CHP) production. Biomass resources are distributed, thus decentralized biomass conversion would avoid extensive cost...... data from Topsoe Fuel Cells A/S. The SOFC component model predicts the SOFC performance at various operating conditions and is suited for implementation in system-level models using the simulation software DNA. Furthermore, it is used for issuing guidelines for optimal SOFC operation. A system...

  2. Modeling of Integrated Nanoneedle-Microfluidic System for Single Cell Temperature Measurement

    Directory of Open Access Journals (Sweden)

    Salma Abdullah Binsilm

    2016-12-01

    Full Text Available In this research, a finite element study on a nanoneedle-microfluidic system for single cell temperature measurement is presented. The nanoneedle design and electrical and mechanical characterization are analyzed, in which tungsten is used as the sensing material. A rectangular shaped sensor with a gap of 10.8 µm showed to give the same current density distribution within the nanoneedle, and a 90 nm2 cross-sectional area showed to cause minimum damage to the cell. Furthermore, the current showed to have a positive temperature coefficient of resistance (TCR with an increase in the temperature, and the nanoneedle showed to be able to resist ramp force up to 22.5 μN before failure. Electrical measurement on yeast cell showed that the nanoneedle was independent of the cell conductivity. The nanoneedle proved to be able to measure temperature with a current difference of 50 nA and a resolution of 0.02 °C in 10 ms. A Y-shaped microchannel was proposed and the microchannel cross-sectional area was optimized to be 63 μm2 and a flow rate of 24.6 pL/min allowed successful cell penetration causing minimal damage to the cell.

  3. Discrete integrable system and its integrable coupling

    Institute of Scientific and Technical Information of China (English)

    LI Zhu

    2009-01-01

    This paper derives new discrete integrable system based on discrete isospectral problem. It shows that the hierarchy is completely integrable in the Liouville sense and possesses bi-Hamiltonian structure. Finally, integrable couplings of the obtained system is given by means of semi-direct sums of Lie algebras.

  4. HT-PEM Fuel Cell System with Integrated Thermoelectric Exhaust Heat Recovery

    DEFF Research Database (Denmark)

    Gao, Xin

    for electricity. For this aim, a heat exchanger based TEG heat recovery subsystem is designed. Instead of optimizing an ordinary rectangular heat exchanger, high efficient and commercialized compact plate-fin exchangers are applied. A library of types of them is also included to pinpoint the ideal heat exchanger...... power output on the subsystem design and performance were also systematically analyzed. The TEG subsystem configuration is optimized. The usefulness and convenience of the model are proved. TE coolers (TECs) are integrated into the methanol evaporator of the HT-PEM system for improving the whole system...... in literature are reviewed for their experiences. Afterwards, the project road map is identified by a list of project objectives. The detailed considerations and steps during carrying out the project are addressed in the second chapter. Major innovations out of this project are also highlighted. The third...

  5. Self-feeding paper based biofuel cell/self-powered hybrid μ-supercapacitor integrated system.

    Science.gov (United States)

    Narvaez Villarrubia, Claudia W; Soavi, Francesca; Santoro, Carlo; Arbizzani, Catia; Serov, Alexey; Rojas-Carbonell, Santiago; Gupta, Gautam; Atanassov, Plamen

    2016-12-15

    For the first time, a paper based enzymatic fuel cell is used as self-recharged supercapacitor. In this supercapacitive enzymatic fuel cell (SC-EFC), the supercapacitive features of the electrodes are exploited to demonstrate high power output under pulse operation. Glucose dehydrogenase-based anode and bilirubin oxidase-based cathode were assembled to a quasi-2D capillary-driven microfluidic system. Capillary flow guarantees the continuous supply of glucose, cofactor and electrolytes to the anodic enzyme and the gas-diffusional cathode design provides the passive supply of oxygen to the catalytic layer of the electrode. The paper-based cell was self-recharged under rest and discharged by high current pulses up to 4mAcm(-2). The supercapacitive behavior and low equivalent series resistance of the cell permitted to achieve up to a maximum power of 0.87mWcm(-2) (10.6mW) for pulses of 0.01s at 4mAcm(-2). This operation mode allowed the system to achieve at least one order of magnitude higher current/power generation compared to the steady state operation.

  6. Advanced Integrated Traction System

    Energy Technology Data Exchange (ETDEWEB)

    Greg Smith; Charles Gough

    2011-08-31

    The United States Department of Energy elaborates the compelling need for a commercialized competitively priced electric traction drive system to proliferate the acceptance of HEVs, PHEVs, and FCVs in the market. The desired end result is a technically and commercially verified integrated ETS (Electric Traction System) product design that can be manufactured and distributed through a broad network of competitive suppliers to all auto manufacturers. The objectives of this FCVT program are to develop advanced technologies for an integrated ETS capable of 55kW peak power for 18 seconds and 30kW of continuous power. Additionally, to accommodate a variety of automotive platforms the ETS design should be scalable to 120kW peak power for 18 seconds and 65kW of continuous power. The ETS (exclusive of the DC/DC Converter) is to cost no more than $660 (55kW at $12/kW) to produce in quantities of 100,000 units per year, should have a total weight less than 46kg, and have a volume less than 16 liters. The cost target for the optional Bi-Directional DC/DC Converter is $375. The goal is to achieve these targets with the use of engine coolant at a nominal temperature of 105C. The system efficiency should exceed 90% at 20% of rated torque over 10% to 100% of maximum speed. The nominal operating system voltage is to be 325V, with consideration for higher voltages. This project investigated a wide range of technologies, including ETS topologies, components, and interconnects. Each technology and its validity for automotive use were verified and then these technologies were integrated into a high temperature ETS design that would support a wide variety of applications (fuel cell, hybrids, electrics, and plug-ins). This ETS met all the DOE 2010 objectives of cost, weight, volume and efficiency, and the specific power and power density 2015 objectives. Additionally a bi-directional converter was developed that provides charging and electric power take-off which is the first step

  7. The "Integrated Library System."

    Science.gov (United States)

    Dowlin, Kenneth E.

    1985-01-01

    Reviews internal and external dimensions of library environment that must be taken into account by library managers when choosing an integrated library system. The selection, acquisition, and implementation stages of Maggie III--a computerized library system sensitive to the internal and external organizational environment--are described. (MBR)

  8. Three dimensional system integration

    CERN Document Server

    Papanikolaou, Antonis; Radojcic, Riko

    2010-01-01

    Three-dimensional (3D) integrated circuit (IC) stacking is the next big step in electronic system integration. It enables packing more functionality, as well as integration of heterogeneous materials, devices, and signals, in the same space (volume). This results in consumer electronics (e.g., mobile, handheld devices) which can run more powerful applications, such as full-length movies and 3D games, with longer battery life. This technology is so promising that it is expected to be a mainstream technology a few years from now, less than 10-15 years from its original conception. To achieve thi

  9. An integrated microfluidic system for screening of phage-displayed peptides specific to colon cancer cells and colon cancer stem cells.

    Science.gov (United States)

    Che, Yu-Jui; Wu, Huei-Wen; Hung, Lien-Yu; Liu, Ching-Ann; Chang, Hwan-You; Wang, Kuan; Lee, Gwo-Bin

    2015-09-01

    Affinity reagents recognizing biomarkers specifically are essential components of clinical diagnostics and target therapeutics. However, conventional methods for screening of these reagents often have drawbacks such as large reagent consumption, the labor-intensive or time-consuming procedures, and the involvement of bulky or expensive equipment. Alternatively, microfluidic platforms could potentially automate the screening process within a shorter period of time and reduce reagent and sample consumption dramatically. It has been demonstrated recently that a subpopulation of tumor cells known as cancer stem cells possess high drug resistance and proliferation potential and are regarded as the main cause of metastasis. Therefore, a peptide that recognizes cancer stem cells and differentiates them from other cancer cells will be extremely useful in early diagnosis and target therapy. This study utilized M13 phage display technology to identify peptides that bind, respectively, to colon cancer cells and colon cancer stem cells using an integrated microfluidic system. In addition to positive selection, a negative selection process was integrated on the chip to achieve the selection of peptides of high affinity and specificity. We successfully screened three peptides specific to colon cancer cells and colon cancer stem cells, namely, HOLC-1, HOLC-2, and COLC-1, respectively, and their specificity was measured by the capture rate between target, control, and other cell lines. The capture rates are 43.40 ± 7.23%, 45.16 ± 7.12%, and 49.79 ± 5.34% for colon cancer cells and colon cancer stem cells, respectively, showing a higher specificity on target cells than on control and other cell lines. The developed technique may be promising for early diagnosis of cancer cells and target therapeutics.

  10. Power conditioning system topology for grid integration of wind and fuell cell energy

    Directory of Open Access Journals (Sweden)

    Marian GAICEANU

    2006-12-01

    Full Text Available This paper shows the topology of the hybrid grid-connected power system and the performances of the front-end three-phase power inverter. The renewable sources of the hybrid power system consist of a solid oxide fuel cell and a wind-turbine. This type of combination is the most efficient one. The proposed topology benefits of the one common DC-AC inverter which injects the generated power into the grid. The architecture diminishes the cost of the power conditioning system. Moreover, due to the power balance control of the entire power conditioning system the bulk dc link electrolytic capacitor is replaced with a small plastic film one. The final power conditioning system has the following advantages: independent control of the reactive power, minimize harmonic current distortion offering a nearly unity power factor operation (0,998 operation capability, dc link voltage regulation (up to 5% ripple in the dc-link voltage in any operated conditions, fast disturbance compensation capability, high reliability, and low cost. The experimental test has been performed and the performances of the grid power inverter are shown.

  11. Integrated Cellular and Plasma Proteomics of Contrasting B-cell Cancers Reveals Common, Unique and Systemic Signatures.

    Science.gov (United States)

    Johnston, Harvey E; Carter, Matthew J; Cox, Kerry L; Dunscombe, Melanie; Manousopoulou, Antigoni; Townsend, Paul A; Garbis, Spiros D; Cragg, Mark S

    2017-03-01

    Approximately 800,000 leukemia and lymphoma cases are diagnosed worldwide each year. Burkitt's lymphoma (BL) and chronic lymphocytic leukemia (CLL) are examples of contrasting B-cell cancers; BL is a highly aggressive lymphoid tumor, frequently affecting children, whereas CLL typically presents as an indolent, slow-progressing leukemia affecting the elderly. The B-cell-specific overexpression of the myc and TCL1 oncogenes in mice induce spontaneous malignancies modeling BL and CLL, respectively. Quantitative mass spectrometry proteomics and isobaric labeling were employed to examine the biology underpinning contrasting Eμ-myc and Eμ-TCL1 B-cell tumors. Additionally, the plasma proteome was evaluated using subproteome enrichment to interrogate biomarker emergence and the systemic effects of tumor burden. Over 10,000 proteins were identified (qIL5) receptor. IL5 treatment promoted Eμ-TCL1 tumor proliferation, suggesting an amplification of IL5-induced AKT signaling by TCL1. Tumor plasma contained a substantial tumor lysis signature, most prominent in Eμ-myc plasma, whereas Eμ-TCL1 plasma contained signatures of immune-response, inflammation and microenvironment interactions, with putative biomarkers in early-stage cancer. These findings provide a detailed characterization of contrasting B-cell tumor models, identifying common and specific tumor mechanisms. Integrated plasma proteomics allowed the dissection of a systemic response and a tumor lysis signature present in early- and late-stage cancers, respectively. Overall, this study suggests common B-cell cancer signatures exist and illustrates the potential of the further evaluation of B-cell cancer subtypes by integrative proteomics.

  12. Integration and evaluation of a power system for remote application based on PV panels and PEM fuel cell

    Energy Technology Data Exchange (ETDEWEB)

    Isorna Llerena, F.; Anchuelo Hebrero, C.; Argumosa, P.; Gonzalez, A.; Gonzalez, C. [Instituto Nacional de Tecnica Aeroespacial (INTA), Departamento de Aerodinamica y Propulsion Carretera de Ajalvir, Madrid (Spain)

    2003-09-01

    The 'Fuel Cell Innovative Remote Systems for Telecom' is a Research, Development and Demonstration project co-funded by the European Commission. Seven institutions from four different European countries are partners of the project and carry out the technical work of the project, there are four research centres and three private companies. In addition a 'Board of Interest', integrated by companies dealing with remote telecom systems and uninterrupted power systems, has been established and takes the responsibilities for the exploitation plan of the whole developed system. INTA is the coordinator of the project and this paper will be focused in the showcase 1, installed at INTA facilities. The total budget of the project is 3.400.000 Euro. The project will finish on March 2004. (authors)

  13. Integration and evaluation of a power system for remote application based on PV panels and PEM fuel cell

    Energy Technology Data Exchange (ETDEWEB)

    Llerena, F.I.; Hebrero, C.A.; Argumosa, P.; Gonzalez, A.; Gonzalez, C. [Departamento de Aerodinamica y Propulsion. Instituto Nacional de Tecnica Aeroespacial (INTA), Madrid (Spain)

    2003-09-01

    The 'Fuel Cell Innovative Remote Systems for Telecom' is a Research, Development and Demonstration project co-funded by the European Commission. Seven institutions from four different European countries are partners of the project and carry out the technical work of the project, there are four research centres and three private companies. In addition a 'Board of Interest', integrated by companies dealing with remote telecom systems and uninterrupted power systems, has been established and takes the responsibilities for the exploitation plan of the whole developed system. INTA is the coordinator of the project and this paper will be focused in the showcase 1, installed at INTA facilities. The total budget of the project is 3.400.000 Euro. The project will finish on March 2004. (authors)

  14. Modelling of pressurised hybrid systems based on integrated planar solid oxide fuel cell (IP-SOFC) technology

    Energy Technology Data Exchange (ETDEWEB)

    Magistri, L.; Traverso, A.; Massardo, A.F. [TPG-DIMSET, University of Genoa, Via Montallegro 1, 16145 Genova (Italy); Cerutti, F.; Costamagna, P. [TPG-DICHEP, University of Genoa, Via Opera Pia 15, 16145 Genova (Italy); Bozzolo, M. [Rolls-Royce Fuel Cell Systems Ltd, PO Box 31, Derby DE24 8BJ (United Kingdom)

    2005-02-01

    This work describes different models, developed by the Thermochemical Power Group at the University of Genoa (Italy), for the simulation of solid oxide fuel cell and gas turbine hybrid systems. The paper focuses on both ''cores'' of the system: the fuel cell stack on the one hand and the turbomachinery and the auxiliaries on the other hand. Therefore, in the first part of the paper the models developed for the analysis of the Rolls-Royce Integrated Planar SOFC cells are presented; the results are compared to experimental data, and carefully analysed and discussed. In the second part of the paper, design and off design models of IP-SOFC pressurised hybrid systems in the range 250 kW-20 MW are presented; the hybrid performance results are presented and discussed, also taking ambient condition effects and a possible control strategy into account. Finally, using an in-house general purpose transient system analysis code (TRANSEO code), where chemical composition, heat transfer, and fluid dynamic influences vs. time are considered in detail, a preliminary time dependent investigation of a pressurised hybrid system behaviour is presented. (Abstract Copyright [2005], Wiley Periodicals, Inc.)

  15. Dark fermentation, anaerobic digestion and microbial fuel cells: An integrated system to valorize swine manure and rice bran.

    Science.gov (United States)

    Schievano, Andrea; Sciarria, Tommy Pepè; Gao, Yong Chang; Scaglia, Barbara; Salati, Silvia; Zanardo, Marina; Quiao, Wei; Dong, Renjie; Adani, Fabrizio

    2016-10-01

    This work describes how dark fermentation (DF), anaerobic digestion (AD) and microbial fuel cells (MFC) and solid-liquid separation can be integrated to co-produce valuable biochemicals (hydrogen and methane), bioelectricity and biofertilizers. Two integrated systems (System 1: AD+MFC, and System 2: DF+AD+MFC) are described and compared to a traditional one-stage AD system in converting a mixture (COD=124±8.1gO2kg(-1)Fresh Matter) of swine manure and rice bran. System 1 gave a biomethane yield of 182 LCH4kg(-1)COD-added, while System 2 gave L yields of bio-hydrogen and bio-methane of 27.3±7.2LH2kg(-1)COD-added and 154±14LCH4kg(-1)COD-added, respectively. A solid-liquid separation (SLS) step was applied to the digested slurry, giving solid and liquid fractions. The liquid fraction was treated via the MFC-steps, showing power densities of 12-13Wm(-3) (500Ω) and average bioelectricity yields of 39.8Whkg(-1)COD to 54.2Whkg(-1)COD.

  16. Adaptive control paradigm for photovoltaic and solid oxide fuel cell in a grid-integrated hybrid renewable energy system.

    Science.gov (United States)

    Mumtaz, Sidra; Khan, Laiq

    2017-01-01

    The hybrid power system (HPS) is an emerging power generation scheme due to the plentiful availability of renewable energy sources. Renewable energy sources are characterized as highly intermittent in nature due to meteorological conditions, while the domestic load also behaves in a quite uncertain manner. In this scenario, to maintain the balance between generation and load, the development of an intelligent and adaptive control algorithm has preoccupied power engineers and researchers. This paper proposes a Hermite wavelet embedded NeuroFuzzy indirect adaptive MPPT (maximum power point tracking) control of photovoltaic (PV) systems to extract maximum power and a Hermite wavelet incorporated NeuroFuzzy indirect adaptive control of Solid Oxide Fuel Cells (SOFC) to obtain a swift response in a grid-connected hybrid power system. A comprehensive simulation testbed for a grid-connected hybrid power system (wind turbine, PV cells, SOFC, electrolyzer, battery storage system, supercapacitor (SC), micro-turbine (MT) and domestic load) is developed in Matlab/Simulink. The robustness and superiority of the proposed indirect adaptive control paradigm are evaluated through simulation results in a grid-connected hybrid power system testbed by comparison with a conventional PI (proportional and integral) control system. The simulation results verify the effectiveness of the proposed control paradigm.

  17. Adaptive control paradigm for photovoltaic and solid oxide fuel cell in a grid-integrated hybrid renewable energy system

    Science.gov (United States)

    Khan, Laiq

    2017-01-01

    The hybrid power system (HPS) is an emerging power generation scheme due to the plentiful availability of renewable energy sources. Renewable energy sources are characterized as highly intermittent in nature due to meteorological conditions, while the domestic load also behaves in a quite uncertain manner. In this scenario, to maintain the balance between generation and load, the development of an intelligent and adaptive control algorithm has preoccupied power engineers and researchers. This paper proposes a Hermite wavelet embedded NeuroFuzzy indirect adaptive MPPT (maximum power point tracking) control of photovoltaic (PV) systems to extract maximum power and a Hermite wavelet incorporated NeuroFuzzy indirect adaptive control of Solid Oxide Fuel Cells (SOFC) to obtain a swift response in a grid-connected hybrid power system. A comprehensive simulation testbed for a grid-connected hybrid power system (wind turbine, PV cells, SOFC, electrolyzer, battery storage system, supercapacitor (SC), micro-turbine (MT) and domestic load) is developed in Matlab/Simulink. The robustness and superiority of the proposed indirect adaptive control paradigm are evaluated through simulation results in a grid-connected hybrid power system testbed by comparison with a conventional PI (proportional and integral) control system. The simulation results verify the effectiveness of the proposed control paradigm. PMID:28329015

  18. Discrete systems and integrability

    CERN Document Server

    Hietarinta, J; Nijhoff, F W

    2016-01-01

    This first introductory text to discrete integrable systems introduces key notions of integrability from the vantage point of discrete systems, also making connections with the continuous theory where relevant. While treating the material at an elementary level, the book also highlights many recent developments. Topics include: Darboux and Bäcklund transformations; difference equations and special functions; multidimensional consistency of integrable lattice equations; associated linear problems (Lax pairs); connections with Padé approximants and convergence algorithms; singularities and geometry; Hirota's bilinear formalism for lattices; intriguing properties of discrete Painlevé equations; and the novel theory of Lagrangian multiforms. The book builds the material in an organic way, emphasizing interconnections between the various approaches, while the exposition is mostly done through explicit computations on key examples. Written by respected experts in the field, the numerous exercises and the thoroug...

  19. Integrated management systems

    DEFF Research Database (Denmark)

    Jørgensen, Tine Herreborg; Remmen, Arne; Mellado, M. Dolores

    2006-01-01

    Different approaches to integration of management systems (ISO 9001, ISO 14001, OHSAS 18001 and SA 8000) with various levels of ambition have emerged. The tendency of increased compatibility between these standards has paved the road for discussions of, how to understand the different aspects of ...

  20. Integrable and superintegrable systems

    CERN Document Server

    1990-01-01

    Some of the most active practitioners in the field of integrable systems have been asked to describe what they think of as the problems and results which seem to be most interesting and important now and are likely to influence future directions. The papers in this collection, representing their authors' responses, offer a broad panorama of the subject as it enters the 1990's.

  1. Power Systems integration

    Science.gov (United States)

    Brantley, L. W.

    1982-01-01

    Power systems integration in large flexible space structures is discussed with emphasis upon body control. A solar array is discussed as a typical example of spacecraft configuration problems. Information on how electric batteries dominate life-cycle costs is presented in chart form. Information is given on liquid metal droplet generators and collectors, hot spot analysis, power dissipation in solar arrays, solar array protection optimization, and electromagnetic compatibility for a power system platform.

  2. Solid oxide fuel cell (SOFC) systems with integrated reforming or gasification of hydrocarbons; Solid Oxide Fuel Cell (SOFC)-Systeme mit integrierter Reformierung bzw. Vergasung von Kohlenwasserstoffen

    Energy Technology Data Exchange (ETDEWEB)

    Schlitzberger, Christian

    2012-07-01

    In this thesis, innovative concepts for structurally, thermally and materially integrated SOFC-systems with optional CO{sub 2}-capture are developed and analyzed. Initially, options to increase the electrical system-efficiency as coupling of fuel reforming and fuel cell based on the principle of the chemical heat pump and a electrically cascaded stack structure are developed and evaluated regarding e.g. theoretically achievable efficiencies. Based on this evaluation and the state of the art, a new planar stack- and system-design with direct internal reforming and without bipolar plates is systematically constructed. This basic unit can be adopted to different fuel-, operation- and application-requirements and represents a compact system with only few balance-of-plant-components. Due to the thermal and material couplings, the SOFC-waste heat can be directly used to supply the necessary heat for the endothermic reforming process. Additionally, a part of the hot anode off-gas, consisting mainly of water vapor, is recycled as a reforming agent. Therefore, based on the principle of the chemical heat pump, depending on the fuel used, system efficiencies of more than 60% can be achieved, even though the SOFC itself reached only an electrical efficiency of approximately 50%. Because of the cascaded SOFC structure resulting in high fuel utilization, postcombustion of the waste gases is no longer necessary. Due to the fact that SOFC membrane allows only an oxygen-ion flow and thus represents an air separation unit and the SOFC design without the mixing of anode and cathode flows, a simple CO{sub 2}-separation can be realized by condensing the water vapor out of the anode off-gas. In the second part of the thesis mathematical models of the SOFC-system-components are developed and implemented in the C++ based cycle simulation software ENBIPRO (Energie-Bilanz-Programm) owned by the institute. Applying the mathematical models different stack- and system-concepts for several

  3. The TIF1β-HP1 System Maintains Transcriptional Integrity of Hematopoietic Stem Cells

    Directory of Open Access Journals (Sweden)

    Satoru Miyagi

    2014-02-01

    Full Text Available TIF1β is a transcriptional corepressor that recruits repressive chromatin modifiers to target genes. Its biological function and physiological targets in somatic stem cells remain largely unknown. Here, we show that TIF1β is essential for the maintenance of hematopoietic stem cells (HSCs. Deletion of Tif1b in mice induced active cycling and apoptosis of HSCs and promoted egression of HSCs from the bone marrow, leading to rapid depletion of HSCs. Strikingly, Tif1b-deficient HSCs showed a strong trend of ectopic expression of nonhematopoietic genes. Levels of heterochromatin protein 1 (HP1α, β and γ proteins, which form a complex with TIF1β, were significantly reduced in the absence of TIF1β and depletion of HP1 recapitulated a part of the phenotypes of Tif1b-deficient HSCs. These results demonstrate that the TIF1β-HP1 system functions as a critical repressive machinery that targets genes not normally activated in the hematopoietic compartment, thereby maintaining the transcriptional signature specific to HSCs.

  4. Construction of a test platform for Test Blanket Module (TBM) systems integration and maintenance in ITER Port Cell #16

    Energy Technology Data Exchange (ETDEWEB)

    Vála, Ladislav, E-mail: ladislav.vala@cvrez.cz [Centrum výzkumu Řež, Hlavní 130, 250 68 Husinec-Řež (Czech Republic); Reungoat, Mathieu, E-mail: mathieu.reungoat@cvrez.cz [Centrum výzkumu Řež, Hlavní 130, 250 68 Husinec-Řež (Czech Republic); Vician, Martin [Centrum výzkumu Řež, Hlavní 130, 250 68 Husinec-Řež (Czech Republic); Poitevin, Yves; Ricapito, Italo; Zmitko, Milan; Panayotov, Dobromir [Fusion for Energy, Josep Pla 2, Torres Diagonal Litoral B3, 08019 Barcelona (Spain)

    2015-10-15

    Highlights: • A non-nuclear, full size facility – TBM platform – is under construction in CVR. • It is designed for tests, optimization and validation of TBS maintenance operations. • It will allow testing and validation of specific maintenance tools and RH equipment. • It reproduces ITER Port Cell #16, as well as the TBS interfaces and main equipment. • The TBM platform will be available for full operation in the first half of 2016. - Abstract: This paper describes a project of a non-nuclear, 1:1 scale testing platform dedicated to tests, optimization and validation of integration and maintenance operations for the European TBM systems in the ITER Port Cell #16. This TBM platform is currently under construction in Centrum výzkumu Řež, Czech Republic. The facility is realized within the scope of the SUSEN project and its full operation is foreseen in the first half of 2016.

  5. Hybrid electric system based on fuel cell and battery and integrating a single dc/dc converter for a tramway

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, Luis M., E-mail: luis.fernandez@uca.e [Department of Electrical Engineering, EPS Algeciras, University of Cadiz, Avda. Ramon Puyol, s/n. 11202 Algeciras (Cadiz) (Spain); Garcia, Pablo, E-mail: pablo.garcia@uca.e [Department of Electrical Engineering, EPS Algeciras, University of Cadiz, Avda. Ramon Puyol, s/n. 11202 Algeciras (Cadiz) (Spain); Garcia, Carlos Andres, E-mail: carlosandres.garcia@uca.e [Department of Electrical Engineering, EPS Algeciras, University of Cadiz, Avda. Ramon Puyol, s/n. 11202 Algeciras (Cadiz) (Spain); Jurado, Francisco, E-mail: fjurado@ujaen.e [Department of Electrical Engineering, EPS Linares, University of Jaen, C/Alfonso X, No. 28. 23700 Linares (Jaen) (Spain)

    2011-05-15

    Research highlights: {yields} Hybrid electric power system for a real surface tramway. {yields} Hybrid system based on PEM fuel cell with dc/dc converter and Ni-MH battery. {yields} New control strategy for the energy management of the tramway. {yields} Hybrid system demonstrated to meet appropriate driving cycle of the tramway. -- Abstract: This paper presents a hybrid electric power system for a real surface tramway. The hybrid system consists of two electrical energy sources integrating a single dc/dc converter to provide the power demanded by the tramway loads (four electric traction motors and auxiliary services): (1) a Polymer Electrolyte Membrane (PEM) fuel cell (FC) as the primary and (2) a rechargeable Ni-MH battery as electrical energy storage to supplement the FC over the driving cycle. According to the requirements of the real driving cycle of the tramway, it was considered a 200 kW PEM FC system with two FCs connected in parallel and a 34 Ah Ni-MH battery. The PEM FC and Ni-MH battery models were designed from commercially available components. The power conditioning system provides the appropriate power for the tramway. It is composed of: (1) a unique dc/dc boot converter which adapts the FC output voltage to the 750 V traction standard dc bus; (2) three phase inverters to drive properly each electric motors; and (3) a braking chopper to dissipate excess of regenerative braking energy. Suitable state machine control architecture is presented for the hybrid system, its objective being to provide demanded power by the driving cycle, optimizing the energy generated. Following this objective, a new state machine control strategy based on eight states decides the operating point of each component of the system and a cascade control structure allows achieving the operating points determined by the strategy. Simulation results of the real driving cycle of the tramway check the adequacy of the hybrid electric power system.

  6. Integrated Microchannel Reformer/Hydrogen Purifier for Fuel Cell Power Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Makel Engineering, Inc. (MEI) supported by Lockheed Martin and the Colorado School of Mines (CSM) propose to develop an integrated hydrogen generator and purifier...

  7. Systems of integrable derivations

    Directory of Open Access Journals (Sweden)

    Vittoria Bonanzinga

    1994-05-01

    Full Text Available Let A be a commutative k-algebra, with k a subring of A. We give the definition of n-dimensional differentiation of A over k which formally extends the known one of unidimensional differentiation and we study the group of all n-dimensional differentiation of A over k. In the second part of the work we give some theorems of strong integrability for systems of derivations in terms of n-dimensional differentiation.

  8. Thermal coupling potential of Solid Oxide Fuel Cells with metal hydride tanks: Thermodynamic and design considerations towards integrated systems

    Science.gov (United States)

    Yiotis, Andreas G.; Kainourgiakis, Michael E.; Kosmidis, Lefteris I.; Charalambopoulou, Georgia C.; Stubos, Athanassios K.

    2014-12-01

    We study the thermal coupling potential between a high temperature metal hydride (MH) tank and a Solid Oxide Fuel Cell (SOFC) aiming towards the design of an efficient integrated system, where the thermal power produced during normal SOFC operation is redirected towards the MH tank in order to maintain H2 desorption without the use of external heating sources. Based on principles of thermodynamics, we calculate the energy balance in the SOFC/MH system and derive analytical expressions for both the thermal power produced during SOFC operation and the corresponding thermal power required for H2 desorption, as a function of the operating temperature, efficiency and fuel utilization ratio in the SOFC, and the MH enthalpy of desorption in the tank. Based on these calculations, we propose an integrated SOFC/MH design where heat is transferred primarily by radiation to the tank in order to maintain steady-state desorption conditions. We develop a mathematical model for this particular design that accounts for heat/mass transfer and desorption kinetics in the tank, and solve for the dynamics of the system assuming MgH2 as a storage material. Our results focus primarily on tank operating conditions, such as pressure, temperature and H2 saturation profiles vs operation time.

  9. Slimplectic Integrators: Variational Integrators for Nonconservative systems

    Science.gov (United States)

    Tsang, David

    2016-05-01

    Symplectic integrators are widely used for long-term integration of conservative astrophysical problems due to their ability to preserve the constants of motion; however, they cannot in general be applied in the presence of nonconservative interactions. Here we present the “slimplectic” integrator, a new type of numerical integrator that shares many of the benefits of traditional symplectic integrators yet is applicable to general nonconservative systems. We utilize a fixed-time-step variational integrator formalism applied to a newly developed principle of stationary nonconservative action (Galley, 2013, Galley et al 2014). As a result, the generalized momenta and energy (Noether current) evolutions are well-tracked. We discuss several example systems, including damped harmonic oscillators, Poynting-Robertson drag, and gravitational radiation reaction, by utilizing our new publicly available code to demonstrate the slimplectic integrator algorithm. Slimplectic integrators are well-suited for integrations of systems where nonconservative effects play an important role in the long-term dynamical evolution. As such they are particularly appropriate for cosmological or celestial N-body dynamics problems where nonconservative interactions, e.g., gas interactions or dissipative tides, can play an important role.

  10. Integrated healthcare information systems.

    Science.gov (United States)

    Miller, J

    1995-01-01

    When it comes to electronic data processing in healthcare, we offer a guarded, but hopeful, prognosis. To be sure, the age of electronic information processing has hit healthcare. Employers, insurance companies, hospitals, physicians and a host of ancillary service providers are all being ushered into a world of high speed, high tech electronic information. Some are even predicting that the health information business will grow from $20 billion to over $100 billion in a decade. Yet, out industry lags behind other industries in its overall movement to the paperless world. Selecting and installing the most advanced integrated information system isn't a simple task, as we've seen. As in life, compromises can produce less than optimal results. Nevertheless, integrated healthcare systems simply won't achieve their goals without systems designed to support the operation of a continuum of services. That's the reality! It is difficult to read about the wonderful advances in other sectors, while realizing that many trees still fall each year in the name of the health care industry. Yes, there are some outstanding examples of organizations pushing the envelop in a variety of areas. Yet from a very practical standpoint, many (like our physician's office) are still struggling or are on the sidelines wondering what to do. Given the competitive marketplace, organizations without effective systems may not have long to wonder and wait.

  11. Integrated Information Systems

    Directory of Open Access Journals (Sweden)

    Annika Moscati

    2012-11-01

    Full Text Available Currently in the field of management, enhancement, territory and cultural heritage analysis, two types of information systems offer significant tools: GIS (Geographic Information System and AIS (Architectural Information System. The first one manages urban and territorial scale data, the second one administers architectural scale data. For a complete management and analysis of heritage both scales (territorial-urban and architectural are essential. But despite numerous attempts made in recent years, currently no system is really able to manage them simultaneously. This study aims to create a hybrid system, which is a new interface that allows to simultaneously view an AIS, a GIS and a window for management of spatial queries. Considering the profound differences between the two systems, the ultimate goal is to integrate them by proposing a new Hybrid System (HS to solve the problem of scale change (from analysis to synthesis using a new data structure and a new interface. To achieve the ultimate goal it has been studied mainly: a the possibilities of implementation of the two systems; b spatial analysis and 3D topology.

  12. Biosensors and Biofuel Cells based on Vertically Aligned Carbon Nanotubes for Integrated Energy Sensing, Generation, and Storage (SGS) Systems

    Science.gov (United States)

    Pandey, Archana; Prasad, Abhishek; Khin Yap, Yoke

    2010-03-01

    Diabetes is a growing health issue in the nation. Thus in-situ glucose sensors that can monitor the glucose level in our body are in high demand. Furthermore, it will be exciting if the excessive blood sugar can be converted into usable energy, and be stored in miniature batteries for applications. This will be the basis for an integrated energy sensing, generation, and storage (SGS) system in the future. Here we report the use of functionalized carbon nanotubes arrays as the glucose sensors as well as fuel cells that can convert glucose into energy. In principle, these devices can be integrated to detect excessive blood glucose and then convert the glucose into energy. They are also inline with our efforts on miniature 3D microbatteries using CNTs [1]. All these devices will be the basis for future SGS systems. Details of these results will be discussed in the meeting. [1] Wang et al., in 206^th Meeting of the Electrochemical Society, October 3-8, Honolulu, Hawaii (2004), Symposium Q1, abstract 1492. Y. K. Yap acknowledges supports from DARPA (DAAD17-03-C-0115), USDA (2007-35603-17740), and the Multi-Scale Technologies Institute (MuSTI) at MTU.

  13. Hydrogen production with integrated microchannel fuel processor for portable fuel cell systems

    Science.gov (United States)

    Park, Gu-Gon; Yim, Sung-Dae; Yoon, Young-Gi; Lee, Won-Yong; Kim, Chang-Soo; Seo, Dong-Joo; Eguchi, Koichi

    An integrated microchannel methanol processor was developed by assembling unit reactors, which were fabricated by stacking and bonding microchannel patterned stainless steel plates, including fuel vaporizer, heat exchanger, catalytic combustor and steam reformer. Commercially available Cu/ZnO/Al 2O 3 catalyst was coated inside the microchannel of the unit reactor for steam reforming. Pt/Al 2O 3 pellets prepared by 'incipient wetness' were filled in the cavity reactor for catalytic combustion. Those unit reactors were integrated to develop the fuel processor and operated at different reaction conditions to optimize the reactor performance, including methanol steam reformer and methanol catalytic combustor. The optimized fuel processor has the dimensions of 60 mm × 40 mm × 30 mm, and produced 450sccm reformed gas containing 73.3% H 2, 24.5% CO 2 and 2.2% CO at 230-260 °C which can produce power output of 59 Wt.

  14. Fuel cell system with interconnect

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Zhien; Goettler, Richard

    2016-12-20

    The present invention includes an integrated planar, series connected fuel cell system having electrochemical cells electrically connected via interconnects, wherein the anodes of the electrochemical cells are protected against Ni loss and migration via an engineered porous anode barrier layer.

  15. TCR industrial system integration strategy

    CERN Document Server

    Bartolomé, R; Sollander, P; Martini, R; Vercoutter, B; Trebulle, M

    1999-01-01

    New turnkey data acquisition systems purchased from industry are being integrated into CERN's Technical Data Server. The short time available for system integration and the large amount of data per system require a standard and modular design. Four different integration layers have been defined in order to easily 'plug in' industrial systems. The first layer allows the integration of the equipment at the digital I/O port or fieldbus (Profibus-DP) level. A second layer permits the integration of PLCs (Siemens S5, S7 and Telemecanique); a third layer integrates equipment drivers. The fourth layer integrates turnkey mimic diagrams in the TCR operator console. The second and third layers use two new event-driven protocols based on TCP/IP. Using this structure, new systems are integrated in the data transmission chain, the layer at which they are integrated depending only on their integration capabilities.

  16. A performance analysis of integrated solid oxide fuel cell and heat recovery steam generator for IGFC system

    DEFF Research Database (Denmark)

    Rudra, Souman; Lee, Jinwook; Rosendahl, Lasse

    2010-01-01

    Solid oxide fuel cell (SOFC) is a promising technology for electricity generation. Sulfur-free syngas from a gas-cleaning unit serves as fuel for SOFC in integrated gasification fuel cell (IGFC) power plants. It converts the chemical energy of fuel gas directly into electric energy, thus high...

  17. Biomass-powered Solid Oxide Fuel Cells: Experimental and Modeling Studies for System Integrations

    NARCIS (Netherlands)

    Liu, M.

    2013-01-01

    Biomass is a sustainable energy source which, through thermo-chemical processes of biomass gasification, is able to be converted from a solid biomass fuel into a gas mixture, known as syngas or biosyngas. A solid oxide fuel cell (SOFC) is a power generation device that directly converts the chemical

  18. Biomass-powered Solid Oxide Fuel Cells: Experimental and Modeling Studies for System Integrations

    NARCIS (Netherlands)

    Liu, M.

    2013-01-01

    Biomass is a sustainable energy source which, through thermo-chemical processes of biomass gasification, is able to be converted from a solid biomass fuel into a gas mixture, known as syngas or biosyngas. A solid oxide fuel cell (SOFC) is a power generation device that directly converts the chemical

  19. An uncertain data integration system

    NARCIS (Netherlands)

    Ayat, N.; Afsarmanesh, H.; Akbarinia, R.; Valduriez, P.

    2012-01-01

    Data integration systems offer uniform access to a set of autonomous and heterogeneous data sources. An important task in setting up a data integration system is to match the attributes of the source schemas. In this paper, we propose a data integration system which uses the knowledge implied within

  20. Modelling of Biomass Gasification Integrated with a Solid Oxide Fuel Cell System

    OpenAIRE

    Doherty, Wayne

    2014-01-01

    Biomass is of major interest as a renewable energy source in the context of climate change and energy security. Traditional biomass conversion technologies achieve low electrical efficiencies. Biomass gasification (BG) coupled with fuel cells offer higher efficiencies. Gasification is a process in which a carbonaceous fuel is converted to a combustible gas. It occurs when a controlled amount of oxidant is reacted at high temperatures with available carbon in a fuel within a gasifier. Two tech...

  1. Integrated Electrolysis & Sabatier System for Internal Reforming Regenerative Fuel Cells Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Paragon Space Development Corporation® (Paragon) will advance our Solid Oxide Electrolysis / embedded Sabatier reactors (SOE/ESR) system to generate power from...

  2. Two-component system cross-regulation integrates Bacillus anthracis response to heme and cell envelope stress.

    Directory of Open Access Journals (Sweden)

    Laura A Mike

    2014-03-01

    Full Text Available Two-component signaling systems (TCSs are one of the mechanisms that bacteria employ to sense and adapt to changes in the environment. A prototypical TCS functions as a phosphorelay from a membrane-bound sensor histidine kinase (HK to a cytoplasmic response regulator (RR that controls target gene expression. Despite significant homology in the signaling domains of HKs and RRs, TCSs are thought to typically function as linear systems with little to no cross-talk between non-cognate HK-RR pairs. Here we have identified several cell envelope acting compounds that stimulate a previously uncharacterized Bacillus anthracis TCS. Furthermore, this TCS cross-signals with the heme sensing TCS HssRS; therefore, we have named it HssRS interfacing TCS (HitRS. HssRS reciprocates cross-talk to HitRS, suggesting a link between heme toxicity and cell envelope stress. The signaling between HssRS and HitRS occurs in the parental B. anthracis strain; therefore, we classify HssRS-HitRS interactions as cross-regulation. Cross-talk between HssRS and HitRS occurs at both HK-RR and post-RR signaling junctions. Finally, HitRS also regulates a previously unstudied ABC transporter implicating this transporter in the response to cell envelope stress. This chemical biology approach to probing TCS signaling provides a new model for understanding how bacterial signaling networks are integrated to enable adaptation to complex environments such as those encountered during colonization of the vertebrate host.

  3. Analysis of the control structures for an integrated ethanol processor for proton exchange membrane fuel cell systems

    Science.gov (United States)

    Biset, S.; Nieto Deglioumini, L.; Basualdo, M.; Garcia, V. M.; Serra, M.

    The aim of this work is to investigate which would be a good preliminary plantwide control structure for the process of Hydrogen production from bioethanol to be used in a proton exchange membrane (PEM) accounting only steady-state information. The objective is to keep the process under optimal operation point, that is doing energy integration to achieve the maximum efficiency. Ethanol, produced from renewable feedstocks, feeds a fuel processor investigated for steam reforming, followed by high- and low-temperature shift reactors and preferential oxidation, which are coupled to a polymeric fuel cell. Applying steady-state simulation techniques and using thermodynamic models the performance of the complete system with two different control structures have been evaluated for the most typical perturbations. A sensitivity analysis for the key process variables together with the rigorous operability requirements for the fuel cell are taking into account for defining acceptable plantwide control structure. This is the first work showing an alternative control structure applied to this kind of process.

  4. Analysis of the control structures for an integrated ethanol processor for proton exchange membrane fuel cell systems

    Energy Technology Data Exchange (ETDEWEB)

    Biset, S.; Nieto Deglioumini, L.; Basualdo, M. [GIAIP-CIFASIS (UTN-FRRo-CONICET-UPCAM-UNR), BV. 27 de Febrero 210 Bis, S2000EZP Rosario (Argentina); Garcia, V.M.; Serra, M. [Institut de Robotica i Informatica Industrial, C. Llorens i Artigas 4-6, 08028 Barcelona (Spain)

    2009-07-01

    The aim of this work is to investigate which would be a good preliminary plantwide control structure for the process of Hydrogen production from bioethanol to be used in a proton exchange membrane (PEM) accounting only steady-state information. The objective is to keep the process under optimal operation point, that is doing energy integration to achieve the maximum efficiency. Ethanol, produced from renewable feedstocks, feeds a fuel processor investigated for steam reforming, followed by high- and low-temperature shift reactors and preferential oxidation, which are coupled to a polymeric fuel cell. Applying steady-state simulation techniques and using thermodynamic models the performance of the complete system with two different control structures have been evaluated for the most typical perturbations. A sensitivity analysis for the key process variables together with the rigorous operability requirements for the fuel cell are taking into account for defining acceptable plantwide control structure. This is the first work showing an alternative control structure applied to this kind of process. (author)

  5. Common Systems Integration Lab (CSIL)

    Data.gov (United States)

    Federal Laboratory Consortium — The Common Systems Integration Lab (CSIL)supports the PMA-209 Air Combat Electronics Program Office. CSIL also supports development, test, integration and life cycle...

  6. Towards integrated microliquid handling systems

    NARCIS (Netherlands)

    Elwenspoek, M.; Lammerink, T.S.J.; Miyake, R.; Fluitman, J.H.J.

    1994-01-01

    In this paper we describe components for integrated microliquid handling systems such as fluid injection analysis, and first results of planar integration of components. The components discussed are channels, passive and active valves, actuators for micropumps, micromixers, microflow sensors, optica

  7. Common Systems Integration Lab (CSIL)

    Data.gov (United States)

    Federal Laboratory Consortium — The Common Systems Integration Lab (CSIL)supports the PMA-209 Air Combat Electronics Program Office. CSIL also supports development, test, integration and life cycle...

  8. 77 FR 2521 - Integrated System Power Rates

    Science.gov (United States)

    2012-01-18

    ... Southwestern Power Administration Integrated System Power Rates AGENCY: Southwestern Power Administration, DOE... System pursuant to the Integrated System Rate Schedules which supersede the existing rate schedules... Integrated System pursuant to the following Integrated System Rate Schedules: Rate Schedule P-11,...

  9. Curriculum integration of urinary system

    Institute of Scientific and Technical Information of China (English)

    Min WANG; Li WANG; Wen-xie XU

    2015-01-01

    As the organ-system oriented integration of medical education has been carried out in many domestic medical schools for years,an urgent need of discussions on various problems of integrated medical education emerges.This paper reviews the urinary integrated educational work in Shanghai Jiao Tong University School of Medicine(SJTU-MS)and introduces the contents of the integrated curriculum of urinary system.We focus on whether we should apply the single cycle integration mode or dual cycle mode,and compare the vocational medical education and elite medical education,and demonstrate the importance of inter-system integration and the ideal integrated textbooks.Multifarious teaching methods and other issues are also mentioned.The future development of integrated medical education is prospected positively.

  10. Integrated system checkout report

    Energy Technology Data Exchange (ETDEWEB)

    1991-08-14

    The planning and preparation phase of the Integrated Systems Checkout Program (ISCP) was conducted from October 1989 to July 1991. A copy of the ISCP, DOE-WIPP 90--002, is included in this report as an appendix. The final phase of the Checkout was conducted from July 10, 1991, to July 23, 1991. This phase exercised all the procedures and equipment required to receive, emplace, and retrieve contact handled transuranium (CH TRU) waste filled dry bins. In addition, abnormal events were introduced to simulate various equipment failures, loose surface radioactive contamination events, and personnel injury. This report provides a detailed summary of each days activities during this period. Qualification of personnel to safely conduct the tasks identified in the procedures and the abnormal events were verified by observers familiar with the Bin-Scale CH TRU Waste Test requirements. These observers were members of the staffs of Westinghouse WID Engineering, QA, Training, Health Physics, Safety, and SNL. Observers representing a number of DOE departments, the state of new Mexico, and the Defense Nuclear Facilities Safety Board observed those Checkout activities conducted during the period from July 17, 1991, to July 23, 1991. Observer comments described in this report are those obtained from the staff member observers. 1 figs., 1 tab.

  11. Use of the University of California Los Angeles integrated staging system to predict survival in renal cell carcinoma: an international multicenter study.

    NARCIS (Netherlands)

    Patard, J.J.; Kim, H.L.; Lam, J.; Dorey, F.J.; Pantuck, A.J.; Zisman, A.; Ficarra, V.; Han, K.R.; Cindolo, L.; Taille, A. De La; Tostain, J.; Artibani, W.; Dinney, C.P.; Wood, C.G.; Swanson, D.A.; Abbou, C.C.; Lobel, B.; Mulders, P.F.A.; Chopin, D.K.; Figlin, R.A.; Belldegrun, A.S.

    2004-01-01

    PURPOSE: To evaluate ability of the University of California Los Angeles Integrated Staging System (UISS) to stratify patients with localized and metastatic renal cell carcinoma (RCC) into risk groups in an international multicenter study. PATIENTS AND METHODS: 4,202 patients from eight internationa

  12. Performance of a microbial fuel cell-based biosensor for online monitoring in an integrated system combining microbial fuel cell and upflow anaerobic sludge bed reactor.

    Science.gov (United States)

    Jia, Hui; Yang, Guang; Wang, Jie; Ngo, Huu Hao; Guo, Wenshan; Zhang, Hongwei; Zhang, Xinbo

    2016-10-01

    A hybrid system integrating a microbial fuel cell (MFC)-based biosensor with upflow anaerobic sludge blanket (UASB) was investigated for real-time online monitoring of the internal operation of the UASB reactor. The features concerned were its rapidity and steadiness with a constant operation condition. In addition, the signal feedback mechanism was examined by the relationship between voltage and time point of changed COD concentration. The sensitivity of different concentrations was explored by comparing the signal feedback time point between the voltage and pH. Results showed that the electrical signal feedback was more sensitive than pH and the thresholds of sensitivity were S=3×10(-5)V/(mg/L) and S=8×10(-5)V/(mg/L) in different concentration ranges, respectively. Although only 0.94% of the influent COD was translated into electricity and applied for biosensing, this integrated system indicated great potential without additional COD consumption for real-time monitoring.

  13. Sensor fusion control system for computer integrated manufacturing

    CSIR Research Space (South Africa)

    Kumile, CM

    2007-08-01

    Full Text Available of products in unpredictable quantities. Computer Integrated Manufacturing (CIM) systems plays an important role towards integrating such flexible systems. This paper presents a methodology of increasing flexibility and reusability of a generic CIM cell...

  14. Cycle analysis of an integrated solid oxide fuel cell and recuperative gas turbine with an air reheating system

    Science.gov (United States)

    Zhang, Xiongwen; Li, Jun; Li, Guojun; Feng, Zhenping

    Cycle simulation and analysis for two kinds of SOFC/GT hybrid systems were conducted with the help of the simulation tool: Aspen Custom Modeler. Two cycle schemes of recuperative heat exchanger (RHE) and exhaust gas recirculated (EGR) were described according to the air reheating method. The system performance with operating pressure, turbine inlet temperature and fuel cell load were studied based on the simulation results. Then the effects of oxygen utilization, fuel utilization, operating temperature and efficiencies of the gas turbine components on the system performance of the RHE cycle and the EGR cycle were discussed in detail. Simulation results indicated that the system optimum efficiency for the EGR air reheating cycle scheme was higher than that of the RHE cycle system. A higher pressure ratio would be available for the EGR cycle system in comparison with the RHE cycle. It was found that increasing fuel utilization or oxygen utilization would decrease fuel cell efficiency but improve the system efficiency for both of the RHE and EGR cycles. The efficiency of the RHE cycle hybrid system decreased as the fuel cell air inlet temperature increased. However, the system efficiency of EGR cycle increased with fuel cell air inlet temperature. The effect of turbine efficiency on the system efficiency was more obvious than the effect of the compressor and recuperator efficiencies among the gas turbine components. It was also indicated that improving the gas turbine component efficiencies for the RHE cycle increased system efficiency higher than that for the EGR cycle.

  15. Understanding Patterns for System of Systems Integration

    DEFF Research Database (Denmark)

    Kazman, Rick; Schmid, Klaus; Nielsen, Claus Ballegård

    2013-01-01

    of systems integration patterns. These characteristics at the same time support the architecting process by highlighting important issues a SoS architect needs to consider. We discuss the consolidated template and illustrate it with an example pattern. We also discuss the integration of this novel pattern......Architecting systems of systems is well known to be a formidable challenge. A major aspect in this is defining the integration among the systems that constitute the system of systems. In this paper, we aim to support the SoS architect by systematically developing a way to characterize system...

  16. Integrated systems innovations and applications

    CERN Document Server

    2015-01-01

    This book presents the results of discussions and presentation from the latest ISDT event (2014) which was dedicated to the 94th birthday anniversary of Prof. Lotfi A. Zade, father of Fuzzy logic. The book consists of three main chapters, namely: Chapter 1: Integrated Systems Design Chapter 2: Knowledge, Competence and Business Process Management Chapter 3: Integrated Systems Technologies Each article presents novel and scientific research results with respect to the target goal of improving our common understanding of KT integration.

  17. Design and Control of High Temperature PEM Fuel Cell Systems using Methanol Reformers with Air or Liquid Heat Integration

    DEFF Research Database (Denmark)

    Andreasen, Søren Juhl; Kær, Søren Knudsen; Sahlin, Simon Lennart

    2013-01-01

    The present work describes the ongoing development of high temperature PEM fuel cell systems fuelled by steam reformed methanol. Various fuel cell system solutions exist, they mainly differ depending on the desired fuel used. High temperature PEM (HTPEM) fuel cells offer the possibility of using...... methanol is converted to a hydrogen rich gas with CO2 trace amounts of CO, the increased operating temperatures allow the fuel cell to tolerate much higher CO concentrations than Nafion-based membranes. The increased tolerance to CO also enables the use of reformer systems with less hydrogen cleaning steps...... liquid fuels such as methanol, due to the increased robustness of operating at higher temperatures (160-180oC). Using liquid fuels such as methanol removes the high volume demands of compressed hydrogen storages, simplifies refueling, and enables the use of existing fuel distribution systems. The liquid...

  18. Design and Control of High Temperature PEM Fuel Cell Systems using Methanol Reformers with Air or Liquid Heat Integration

    DEFF Research Database (Denmark)

    Andreasen, Søren Juhl; Sahlin, Simon Lennart; Justesen, Kristian Kjær

    The present work describes the ongoing development of high temperature PEM fuel cell systems fuelled by steam reformed methanol. Various fuel cell system solutions exist, they mainly differ depending on the desired fuel used. High temperature PEM (HTPEM) fuel cells offer the possibility of using...... methanol is converted to a hydrogen rich gas with CO2 trace amounts of CO, the increased operating temperatures allow the fuel cell to tolerate much higher CO concentrations than Nafion-based membranes. The increased tolerance to CO also enables the use of reformer systems with less hydrogen cleaning steps...... liquid fuels such as methanol, due to the increased robustness of operating at higher temperatures (160-180oC). Using liquid fuels such as methanol removes the high volume demands of compressed hydrogen storages, simplifies refueling, and enables the use of existing fuel distribution systems. The liquid...

  19. Tuneable planar integrated optical systems.

    Science.gov (United States)

    Amberg, M; Oeder, A; Sinzinger, S; Hands, P J W; Love, G D

    2007-08-20

    Planar integrated free-space optical systems are well suited for a variety of applications, such as optical interconnects and security devices. Here, we demonstrate for the first time dynamic functionality of such microoptical systems by the integration of adaptive liquid-crystal-devices.

  20. Period Integrals and Tautological Systems

    CERN Document Server

    Lian, Bong H; Yau, Shing-Tung

    2011-01-01

    We study period integrals of CY hypersurfaces in a partial flag variety. We construct a holonomic system of differential equations which govern the period integrals. By means of representation theory, a set of generators of the system can be described explicitly. The results are also generalized to CY complete intersections. The construction of these new systems of differential equations have lead us to the notion of a tautological system.

  1. Smart systems integration and simulation

    CERN Document Server

    Poncino, Massimo; Pravadelli, Graziano

    2016-01-01

    This book-presents new methods and tools for the integration and simulation of smart devices. The design approach described in this book explicitly accounts for integration of Smart Systems components and subsystems as a specific constraint. It includes methodologies and EDA tools to enable multi-disciplinary and multi-scale modeling and design, simulation of multi-domain systems, subsystems and components at all levels of abstraction, system integration and exploration for optimization of functional and non-functional metrics. By covering theoretical and practical aspects of smart device design, this book targets people who are working and studying on hardware/software modelling, component integration and simulation under different positions (system integrators, designers, developers, researchers, teachers, students etc.). In particular, it is a good introduction to people who have interest in managing heterogeneous components in an efficient and effective way on different domains and different abstraction l...

  2. Web Tension regulation of multispan roll-to-roll system using integrated active dancer and load cells for printed electronics applications

    Science.gov (United States)

    Zubair, Muhammad; Ponniah, Ganeshthangaraj; Yang, Young Jin; Choi, Kyung Hyun

    2014-03-01

    The mass production of printed electronics can be achieved by roll-to-roll(R2R) printing system, so highly accurate web tension is required that can minimize the register error and keep the thickness and roughness of printed devices in limits. The web tension of a R2R system is regulated by the use of integrated load cells and active dancer system for printed electronics applications using decentralized multi-input-single-output(MISO) regularized variable learning rate backpropagation artificial neural networks. The active dancer system is used before printing system to reduce disturbances in the web tension of process span. The classical PID control result in tension spikes with the change in roll diameter of winder and unwinder rolls. The presence of dancer in R2R system shows that improved web tension control in printing span and the web tension can be enhanced from 3.75 N to 4.75 N. The overshoot of system is less than ±2.5 N and steady state error is within ±1 N where load cells have a signal noise of ±0.7 N. The integration of load cells and active dancer with self-adapting neural network control provide a solution to the web tension control of multispan roll-to-roll system.

  3. Secure integrated circuits and systems

    CERN Document Server

    Verbauwhede, Ingrid MR

    2010-01-01

    On any advanced integrated circuit or 'system-on-chip' there is a need for security. In many applications the actual implementation has become the weakest link in security rather than the algorithms or protocols. The purpose of the book is to give the integrated circuits and systems designer an insight into the basics of security and cryptography from the implementation point of view. As a designer of integrated circuits and systems it is important to know both the state-of-the-art attacks as well as the countermeasures. Optimizing for security is different from optimizations for speed, area,

  4. Haantjes Manifolds and Integrable Systems

    CERN Document Server

    Tempesta, Piergiulio

    2014-01-01

    A general theory of integrable systems is proposed, based on the theory of Haantjes manifolds. We introduce the notion of symplectic-Haantjes manifold (or $\\omega \\mathcal{H}$ manifold), as the natural setting where the notion of integrability can be formulated. We propose an approach to the separation of variables for classical systems, related to the geometry of Haantjes manifolds. A special class of coordinates, called Darboux-Haantjes coordinates, will be constructed from the Haantjes structure associated with an integrable systems. They enable the additive separation of variables of the Hamilton-Jacobi equation. We also present an application of our approach to the study of some finite-dimensional integrable models, as the H\\'enon-Heiles systems and a stationary reduction of the KdV hierarchy.

  5. Integrated Risk Information System (IRIS)

    Data.gov (United States)

    U.S. Environmental Protection Agency — EPA?s Integrated Risk Information System (IRIS) is a compilation of electronic reports on specific substances found in the environment and their potential to cause...

  6. Integrated Library Systems. ERIC Digest.

    Science.gov (United States)

    Lopata, Cynthia L.

    An automated library system usually consists of a number of functional modules, such as acquisitions, circulation, cataloging, serials, and an online public access catalog (OPAC). An "integrated" library system is an automated system in which all of the function modules share a common bibliographic database. There are several ways the…

  7. Integration of spore-based genetically engineered whole-cell sensing systems into portable centrifugal microfluidic platforms.

    Science.gov (United States)

    Date, Amol; Pasini, Patrizia; Daunert, Sylvia

    2010-09-01

    Bacterial whole-cell biosensing systems provide important information about the bioavailable amount of target analytes. They are characterized by high sensitivity and specificity/selectivity along with rapid response times and amenability to miniaturization as well as high-throughput analysis. Accordingly, they have been employed in various environmental and clinical applications. The use of spore-based sensing systems offers the unique advantage of long-term preservation of the sensing cells by taking advantage of the environmental resistance and ruggedness of bacterial spores. In this work, we have incorporated spore-based whole-cell sensing systems into centrifugal compact disk (CD) microfluidic platforms in order to develop a portable sensing system, which should enable the use of these hardy sensors for fast on-field analysis of compounds of interest. For that, we have employed two spore-based sensing systems for the detection of arsenite and zinc, respectively, and evaluated their analytical performance in the miniaturized microfluidic format. Furthermore, we have tested environmental and clinical samples on the CD microfluidic platforms using the spore-based sensors. Germination of spores and quantitative response to the analyte could be obtained in 2.5-3 h, depending on the sensing system, with detection limits of 1 x 10(-7) M for arsenite and 1 x 10(-6) M for zinc in both serum and fresh water samples. Incorporation of spore-based whole-cell biosensing systems on microfluidic platforms enabled the rapid and sensitive detection of the analytes and is expected to facilitate the on-site use of such sensing systems.

  8. Voice integrated systems

    Science.gov (United States)

    Curran, P. Mike

    1977-01-01

    The program at Naval Air Development Center was initiated to determine the desirability of interactive voice systems for use in airborne weapon systems crew stations. A voice recognition and synthesis system (VRAS) was developed and incorporated into a human centrifuge. The speech recognition aspect of VRAS was developed using a voice command system (VCS) developed by Scope Electronics. The speech synthesis capability was supplied by a Votrax, VS-5, speech synthesis unit built by Vocal Interface. The effects of simulated flight on automatic speech recognition were determined by repeated trials in the VRAS-equipped centrifuge. The relationship of vibration, G, O2 mask, mission duration, and cockpit temperature and voice quality was determined. The results showed that: (1) voice quality degrades after 0.5 hours with an O2 mask; (2) voice quality degrades under high vibration; and (3) voice quality degrades under high levels of G. The voice quality studies are summarized. These results were obtained with a baseline of 80 percent recognition accuracy with VCS.

  9. Integrated Application Software System.

    Science.gov (United States)

    1982-12-01

    spread-shost to complete the celculation/ modelo It compliments the Inclusion of the word ov-.elsor and database manaaement system In the IASS. The...pslces. i isi - -- ----- ... Table 0.3 * VZS!CALC Arithmetic & Aqgregate Functions a, Addition b. Subtraction a, Multiplication d. Division eo

  10. Design and Economic Potential of an Integrated High-Temperature Fuel Cell and Absorption Chiller Combined Cooling, Heat, and Power System

    Science.gov (United States)

    Hosford, Kyle S.

    Clean distributed generation power plants can provide a much needed balance to our energy infrastructure in the future. A high-temperature fuel cell and an absorption chiller can be integrated to create an ideal combined cooling, heat, and power system that is efficient, quiet, fuel flexible, scalable, and environmentally friendly. With few real-world installations of this type, research remains to identify the best integration and operating strategy and to evaluate the economic viability and market potential of this system. This thesis informs and documents the design of a high-temperature fuel cell and absorption chiller demonstration system at a generic office building on the University of California, Irvine (UCI) campus. This work details the extension of prior theoretical work to a financially-viable power purchase agreement (PPA) with regard to system design, equipment sizing, and operating strategy. This work also addresses the metering and monitoring for the system showcase and research and details the development of a MATLAB code to evaluate the economics associated with different equipment selections, building loads, and economic parameters. The series configuration of a high-temperature fuel cell, heat recovery unit, and absorption chiller with chiller exhaust recirculation was identified as the optimal system design for the installation in terms of efficiency, controls, ducting, and cost. The initial economic results show that high-temperature fuel cell and absorption chiller systems are already economically competitive with utility-purchased generation, and a brief case study of a southern California hospital shows that the systems are scalable and viable for larger stationary power applications.

  11. Integrated Satellite-HAP Systems

    DEFF Research Database (Denmark)

    Cianca, Ernestina; De Sanctis, Mauro; De Luise, Aldo

    2005-01-01

    for an efficient hybrid terrestrial-satellite communication system. Two integrated HAP-satellite scenarios are presented, in which the HAP is used to overcome some of the shortcomings of satellite- based communications. Moreover, it is shown that the integration of HAPs with satellite systems can be used......Thus far, high-altitude platform (HAP)-based systems have been mainly conceived as an alternative to satellites for complementing the terrestrial network. This article aims to show that HAP should no longer be seen as a competitor technology by investors of satellites, but as a key element...

  12. Integrated Building Management System (IBMS)

    Energy Technology Data Exchange (ETDEWEB)

    Anita Lewis

    2012-07-01

    This project provides a combination of software and services that more easily and cost-effectively help to achieve optimized building performance and energy efficiency. Featuring an open-platform, cloud- hosted application suite and an intuitive user experience, this solution simplifies a traditionally very complex process by collecting data from disparate building systems and creating a single, integrated view of building and system performance. The Fault Detection and Diagnostics algorithms developed within the IBMS have been designed and tested as an integrated component of the control algorithms running the equipment being monitored. The algorithms identify the normal control behaviors of the equipment without interfering with the equipment control sequences. The algorithms also work without interfering with any cooperative control sequences operating between different pieces of equipment or building systems. In this manner the FDD algorithms create an integrated building management system.

  13. Thermodynamic analyses of municipal solid waste gasification plant integrated with solid oxide fuel cell and Stirling hybrid system

    DEFF Research Database (Denmark)

    Rokni, Masoud

    2015-01-01

    Municipal solid waste (MSW) can be considered a valid biomass to be used in a power plant. The major advantage is the reduction of pollutants and greenhouse gases emissions not only within large cities but also globally. Another advantage is that by their use it is possible to reduce the waste...... process is usually based on an atmospheric-pressure circulating fluidized bed gasifier coupled to a tar-cracking vessel. Syngas can be used as fuel in different kind of power plant such as gas turbine cycle, steam cycle, combined cycle, internal and external combustion engine and Solid Oxide Fuel Cell...... (SOFC).In the present study, a MSW gasification plant integrated with SOFC is combined with a Stirling engine to recover the energy of the off-gases from the topping SOFC cycle. Detailed plant design is proposed and thermodynamic analysis is performed. Relevant parameters have been studied to optimize...

  14. Quantization of noncommutative completely integrable Hamiltonian systems

    CERN Document Server

    Giachetta, G; Sardanashvily, G

    2007-01-01

    Integrals of motion of a Hamiltonian system need not be commutative. The classical Mishchenko-Fomenko theorem enables one to quantize a noncommutative completely integrable Hamiltonian system around its invariant submanifold as an abelian completely integrable Hamiltonian system.

  15. DKIST facility management system integration

    Science.gov (United States)

    White, Charles R.; Phelps, LeEllen

    2016-07-01

    The Daniel K. Inouye Solar Telescope (DKIST) Observatory is under construction at Haleakalā, Maui, Hawai'i. When complete, the DKIST will be the largest solar telescope in the world. The Facility Management System (FMS) is a subsystem of the high-level Facility Control System (FCS) and directly controls the Facility Thermal System (FTS). The FMS receives operational mode information from the FCS while making process data available to the FCS and includes hardware and software to integrate and control all aspects of the FTS including the Carousel Cooling System, the Telescope Chamber Environmental Control Systems, and the Temperature Monitoring System. In addition it will integrate the Power Energy Management System and several service systems such as heating, ventilation, and air conditioning (HVAC), the Domestic Water Distribution System, and the Vacuum System. All of these subsystems must operate in coordination to provide the best possible observing conditions and overall building management. Further, the FMS must actively react to varying weather conditions and observational requirements. The physical impact of the facility must not interfere with neighboring installations while operating in a very environmentally and culturally sensitive area. The FMS system will be comprised of five Programmable Automation Controllers (PACs). We present a pre-build overview of the functional plan to integrate all of the FMS subsystems.

  16. First Integrals and Integral Invariants of Relativistic Birkhoffian Systems

    Institute of Scientific and Technical Information of China (English)

    LUOShao-Kai

    2003-01-01

    For a relativistic Birkhoflan system, the first integrals and the construction of integral invariants are studied. Firstly, the cyclic integrals and the generalized energy integral of the system are found by using the perfect differential method. Secondly, the equations of nonsimultaneous variation of the system are established by using the relation between the simultaneous variation and the nonsimultaneous variation. Thirdly, the relation between the first integral and the integral invariant of the system is studied, and it is proved that, using a t~rst integral, we can construct an integral invarlant of the system. Finally, the relation between the relativistic Birkhoflan dynamics and the relativistic Hamilton;an dynamics is discussed, and the first integrals and the integral invariants of the relativistic Hamiltonian system are obtained. Two examples are given to illustrate the application of the results.

  17. An integrated 45L pilot microbial fuel cell system at a full-scale wastewater treatment plant.

    Science.gov (United States)

    Hiegemann, Heinz; Herzer, Daniel; Nettmann, Edith; Lübken, Manfred; Schulte, Patrick; Schmelz, Karl-Georg; Gredigk-Hoffmann, Sylvia; Wichern, Marc

    2016-10-01

    A 45-L pilot MFC system, consisting of four single-chamber membraneless MFCs, was integrated into a full-scale wastewater treatment plant (WWTP) and operated under practical conditions with the effluent of the primary clarifier for nine months to identify an optimal operational strategy for stable power output and maximum substrate based energy recovery (Normalized Energy Recovery, NER). Best results with the MFC were obtained at a hydraulic retention time of 22h with COD, TSS and nitrogen removal of 24%, 40% and 28%, respectively. Mean NER of 0.36kWhel/kgCOD,deg and coulombic efficiency of 24.8% were reached. Experimental results were used to set up the first described energy balance for a whole WWTP with an integrated MFC system. Energetic calculations of the model WWTP showed that energy savings due to reduced excess sludge production and energy gain of the MFC are significantly higher than the loss of energy due to reduced biogas production.

  18. Systems biology and integrative physiological modelling.

    Science.gov (United States)

    Hester, Robert L; Iliescu, Radu; Summers, Richard; Coleman, Thomas G

    2011-03-01

    Over the last 10 years, 'Systems Biology' has focused on the integration of biology and medicine with information technology and computation. The current challenge is to use the discoveries of the last 20 years, such as genomics and proteomics, to develop targeted therapeutical strategies. These strategies are the result of understanding the aetiologies of complex diseases. Scientists predict the data will make personalized medicine rapidly available. However, the data need to be considered as a highly complex system comprising multiple inputs and feedback mechanisms. Translational medicine requires the functional and conceptual linkage of genetics to proteins, proteins to cells, cells to organs, organs to systems and systems to the organism. To help understand the complex integration of these systems, a mathematical model of the entire human body, which accurately links the functioning of all organs and systems together, could provide a framework for the development and testing of new hypotheses that will be important in clinical outcomes. There are several efforts to develop a 'Human Physiome', with the strengths and weaknesses of each being presented here. The development of a 'Human Model', with verification, documentation and validation of the underlying and integrative responses, is essential to provide a usable environment. Future development of a 'Human Model' requires integrative physiologists working in collaboration with other scientists, who have expertise in all areas of human biology, to develop the most accurate and usable human model.

  19. The Systems Librarian: Re-Integrating the "Integrated" Library System

    Science.gov (United States)

    Breeding, Marshall

    2005-01-01

    This article discusses the current environment of the ILS (Integrated Library System) plus add-ons tailored for electronic content and its future. It suggests that while the ILS may be mature, the supplemental products are not and the linkages among them are even less so. On the technical front, the recent interest in Web services gives reason to…

  20. Integrated immobilized cell reactor-adsorption system for beta-cyclodextrin production: a model study using PVA-cryogel entrapped Bacillus agaradhaerens cells.

    Science.gov (United States)

    Martins, Rita F; Plieva, Fatima M; Santos, Ana; Hatti-Kaul, Rajni

    2003-09-01

    Production of cyclodextrins (CDs) by immobilized cells of the alkaliphilic Bacillus agaradhaerens LS-3C with integrated product recovery was studied. The microorganism was entrapped in polyvinyl alcohol-cryogel beads and used as a convenient source of immobilized cyclodextrin glycosyltransferase (CGTase). On activation by incubation in the cultivation medium containing 1% (w/v) starch, the entrapped cells multiplied and secreted CGTase with an activity of 2-3 mg beta-cyclodextrin h(-1) g(-1) beads. The immobilized biocatalyst exhibited maximum activity at pH 9 and 50 degrees C, and formed cyclodextrins comprising 92-94% beta-CD and remaining alpha-CD. The cyclodextrin product from the immobilized cell bioreactor was continuously recovered by adsorption to Amberlite XAD-4 in a recycle batch mode. The product adsorption was facilitated at low temperature while hot water was used for elution.

  1. An inducible cell-cell fusion system with integrated ability to measure the efficiency and specificity of HIV-1 entry inhibitors.

    Directory of Open Access Journals (Sweden)

    Alon Herschhorn

    Full Text Available HIV-1 envelope glycoproteins (Envs mediate virus entry by fusing the viral and target cell membranes, a multi-step process that represents an attractive target for inhibition. Entry inhibitors with broad-range activity against diverse isolates of HIV-1 may be extremely useful as lead compounds for the development of therapies or prophylactic microbicides. To facilitate the identification of such inhibitors, we have constructed a cell-cell fusion system capable of simultaneously monitoring inhibition efficiency and specificity. In this system, effector cells stably express a tetracycline-controlled transactivator (tTA that enables tightly inducible expression of both HIV-1 Env and the Renilla luciferase (R-Luc reporter protein. Target cells express the HIV-1 receptors, CD4 and CCR5, and carry the firefly luciferase (F-Luc reporter gene under the control of a tTA-responsive promoter. Thus, Env-mediated fusion of these two cell types allows the tTA to diffuse to the target cell and activate the expression of the F-Luc protein. The efficiency with which an inhibitor blocks cell-cell fusion is measured by a decrease in the F-Luc activity, while the specificity of the inhibitor is evaluated by its effect on the R-Luc activity. The system exhibited a high dynamic range and high Z'-factor values. The assay was validated with a reference panel of inhibitors that target different steps in HIV-1 entry, yielding inhibitory concentrations comparable to published virus inhibition data. Our system is suitable for large-scale screening of chemical libraries and can also be used for detailed characterization of inhibitory and cytotoxic properties of known entry inhibitors.

  2. Traction-transport components integrated in fuel cells; running constraints, lifetime, reliability; Les composants traction-transport integres dans les systemes PAC; contraintes de mission, duree de vie, fiabilite

    Energy Technology Data Exchange (ETDEWEB)

    Coquery, G. [Institut National de Recherche sur les transports et leur Securite, INRETS LTN, 94 - Arcueil (France)

    2000-07-01

    The future systems 'fuel cell' on-board in transport vehicles 'SPACT' will be optimized by the control of energy fluxes: of generation, of traction, of recovery to braking and of stored energy. The aim is to reach the level required for the user in terms of reliability, availability, maintainability and safety for a transport vehicle answering to economical and environmental criteria. Despite the obvious necessity of the research and industrialization studies on the 'SPACT' technologies, the current technological advances on the integration of the electronics for traction and the energy storage by super-capacitors and batteries are also determining factors for the industrialization of these hybrid systems. The proposed study presents the constraints of the transport applications, lifetime and reliability, the technologies of the power integration and the future developments of these new components for the transport sector. (O.M.)

  3. Implementation of integrated management system

    Energy Technology Data Exchange (ETDEWEB)

    Gaspar Junior, Joao Carlos A.; Fonseca, Victor Zidan da [Industrias Nucleares do Brasil (INB-RJ) Resende, RJ (Brazil)]. E-mail: joaojunior@inb.gov.br; victorfonseca@inb.gov.br

    2007-07-01

    In present day exist quality assurance system, environment, occupational health and safety such as ISO9001, ISO14001 and OHSAS18001 and others standards will can create. These standards can be implemented and certified they guarantee one record system, quality assurance, documents control, operational control, responsibility definition, training, preparing and serve to emergency, monitoring, internal audit, corrective action, continual improvement, prevent of pollution, write procedure, reduce costs, impact assessment, risk assessment , standard, decree, legal requirements of municipal, state, federal and local scope. These procedure and systems when isolate applied cause many management systems and bureaucracy. Integration Management System reduce to bureaucracy, excess of documents, documents storage and conflict documents and easy to others standards implementation in future. The Integrated Management System (IMS) will be implemented in 2007. INB created a management group for implementation, this group decides planing, works, policy and advertisement. Legal requirements were surveyed, internal audits, pre-audits and audits were realized. INB is partially in accordance with ISO14001, OSHAS18001 standards. But very soon, it will be totally in accordance with this norms. Many studies and works were contracted to deal with legal requirements. This work have intention of show implementation process of ISO14001, OHSAS18001 and Integrated Management System on INB. (author)

  4. Geometric transitions and integrable systems

    NARCIS (Netherlands)

    Diaconescu, D.-E.; Dijkgraaf, R.H.; Donagi, R.; Hofman, C.; Pantev, T.

    2006-01-01

    We consider B-model large N duality for a new class of noncompact Calabi-Yau spaces modeled on the neighborhood of a ruled surface in a Calabi-Yau threefold. The closed string side of the transition is governed at genus zero by an A(1) Hitchin integrable system on a genus g Riemann surface Sigma. Th

  5. Human-System task integration

    NARCIS (Netherlands)

    Schraagen, J.M.C.

    2005-01-01

    The Dutch Ministry of Defence research programme Human-System Task Integration aims at acquiring knowledge for the optimal cooperation between human and computer, under the following constraints: freedom of choice in decisions to automate and multiple, dynamic task distributions. This paper describe

  6. Integrated Systems Health Management for Intelligent Systems

    Science.gov (United States)

    Figueroa, Fernando; Melcher, Kevin

    2011-01-01

    The implementation of an integrated system health management (ISHM) capability is fundamentally linked to the management of data, information, and knowledge (DIaK) with the purposeful objective of determining the health of a system. It is akin to having a team of experts who are all individually and collectively observing and analyzing a complex system, and communicating effectively with each other in order to arrive at an accurate and reliable assessment of its health. In this paper, concepts, procedures, and approaches are presented as a foundation for implementing an intelligent systems ]relevant ISHM capability. The capability stresses integration of DIaK from all elements of a system. Both ground-based (remote) and on-board ISHM capabilities are compared and contrasted. The information presented is the result of many years of research, development, and maturation of technologies, and of prototype implementations in operational systems.

  7. Jacobi fields of completely integrable Hamiltonian systems

    Energy Technology Data Exchange (ETDEWEB)

    Giachetta, G.; Mangiarotti, L.; Sardanashvily, G

    2003-03-31

    We show that Jacobi fields of a completely integrable Hamiltonian system of m degrees of freedom make up an extended completely integrable system of 2m degrees of freedom, where m additional first integrals characterize a relative motion.

  8. Semantic Integration of Information Systems

    Directory of Open Access Journals (Sweden)

    Anna Lisa Guido

    2010-01-01

    Full Text Available In the previous years Information System manage only information inside the company, today a companymay search and manage information of the other companies. In this scenario the problem ofcommunication between Information Systems is of the highest importance. Up to the present moment,several types of integration have been used but all were founded on the agreement (about data to shareand the exchange format between the interested Information Systems. Today, thanks to the newtechnologies, it is possible that an Information System uses data of another Information System without aprevious agreement. The problem is that, often, the Information System may refer to the same data butwith different names. In this paper we present a methodology that, using ontology, and thus the intrinsicsemantic of each data of the Information System, allow to create a global ontology useful to enable asemantic communication between Information Systems.

  9. 78 FR 62616 - Integrated System Power Rates

    Science.gov (United States)

    2013-10-22

    ... Southwestern Power Administration Integrated System Power Rates AGENCY: Southwestern Power Administration, DOE... Integrated System pursuant to the Integrated System Rate Schedules to supersede the existing rate schedules... into effect on an interim basis, increases the power rates for the Integrated System pursuant to...

  10. Derivation, Expansion, and Motor Neuron Differentiation of Human-Induced Pluripotent Stem Cells with Non-Integrating Episomal Vectors and a Defined Xenogeneic-free Culture System.

    Science.gov (United States)

    Hu, Wentao; He, Yongpei; Xiong, Yongjie; Lu, Hong; Chen, Hong; Hou, Limin; Qiu, Zhandong; Fang, Yu; Zhang, Suming

    2016-04-01

    Induced pluripotent stem cells (iPSCs) generated from patient-derived somatic cells provides the opportunity for model development in order to study patient-specific disease states with the potential for drug discovery. However, use of lentivirus and exposure of iPSCs to animal-derived products limit their therapeutic utility and affect lineage differentiation and subsequent downstream functionality of iPSC derivatives. Within the context of this study, we describe a simple and practical protocol enabling the efficient reprogramming of terminally differentiated adult fibroblasts into integration-free human iPSCs (hiPSCs) using a combination of episomal plasmids with small molecules (SMs). Using this approach, there was a 10-fold increase in reprogramming efficiency over single plasmid vector-based methods. We obtained approximately 100 iPSCs colonies from 1 × 10(5) human adult dermal fibroblasts (HADFs) and achieved approximately 0.1% reprogramming efficiencies. Concurrently, we developed a highly conducive culture system using xeno-free media and human vitronectin. The resulting hiPSCs were free of DNA integration and had completely lost episomal vectors, maintained long-term self-renewal, featured a normal karyotype, expressed pluripotent stem cell markers, and possessed the capability of differentiating into components of all three germ layers in vivo. Finally, we demonstrate that the integration-free hiPSCs could be differentiated into motor neurons under xeno-free culture conditions. This induction method will promote the derivation of patient-specific integration-free and xeno-free iPSCs and improve the strategy for motor neuron derivation. Our approach provides a useful tool for human disease models, drug screen, and clinical applications.

  11. Towards an integrated system for bio-energy: hydrogen production by Escherichia coli and use of palladium-coated waste cells for electricity generation in a fuel cell.

    Science.gov (United States)

    Orozco, R L; Redwood, M D; Yong, P; Caldelari, I; Sargent, F; Macaskie, L E

    2010-12-01

    Escherichia coli strains MC4100 (parent) and a mutant strain derived from this (IC007) were evaluated for their ability to produce H(2) and organic acids (OAs) via fermentation. Following growth, each strain was coated with Pd(0) via bioreduction of Pd(II). Dried, sintered Pd-biomaterials ('Bio-Pd') were tested as anodes in a proton exchange membrane (PEM) fuel cell for their ability to generate electricity from H(2). Both strains produced hydrogen and OAs but 'palladised' cells of strain IC007 (Bio-Pd(IC007)) produced ~threefold more power as compared to Bio-Pd(MC4100) (56 and 18 mW respectively). The power output used, for comparison, commercial Pd(0) powder and Bio-Pd made from Desulfovibrio desulfuricans, was ~100 mW. The implications of these findings for an integrated energy generating process are discussed.

  12. Characteristic Classes and Integrable Systems

    CERN Document Server

    Levin, A; Smirnov, A; Zotov, A

    2010-01-01

    The classical Calogero-Moser (CM) system related to a simple Lie group $G$ can be described as the Hitchin system coming from a topologically trivial Higgs $G$-bundle. We consider topologically non-trivial Higgs bundles and construct corresponding integrable systems. We call them the modified Calogero-Moser systems (MCM systems). Their phase space has the same dimension as the phase space of the standard CM systems with spin, but have less number of particles but greater number of the spin variables. Topology of the underlying holomorphic bundles are defined by their characteristic classes. Such bundles occur if $G$ has a non-trivial center, i.e. classical simply-connected groups, $E_6$ and $E_7$. Starting with these bundles we construct new integrable systems, their Lax operators, quadratic Hamiltonians, define the phase spaces and the Poisson structure using dynamical r-matrices. To describe the systems we construct a special basis in the Lie algebras that generalizes the basis of t'Hooft matrices for sl(N)...

  13. First Integrals and Integral Invariants of Relativistic Birkhoffian Systems

    Institute of Scientific and Technical Information of China (English)

    LUO Shao-Kai

    2003-01-01

    For a relativistic Birkhoffian system, the first integrals and the construction of integral invariants arestudied. Firstly, the cyclic integrals and the generalized energy integral of the system are found by using the perfectdifferential method. Secondly, the equations of nonsimultaneous variation of the system are established by using therelation between the simultaneous variation and the nonsimultaneous variation. Thirdly, the relation between the firstintegral and the integral invariant of the system is studied, and it is proved that, using a first integral, we can construct anintegral invariant of the system. Finally, the relation between the relativistic Birkhoffian dynamics and the relativisticHamiltonian dynamics is discussed, and the first integrals and the integral invariants of the relativistic Hamiltoniansystem are obtained. Two examples are given to illustrate the application of the results.

  14. Building scars for integrable systems

    CERN Document Server

    Baldo, Marcello

    1995-01-01

    It is shown, by means of a simple specific example, that for integrable systems it is possible to build up approximate eigenfunctions, called {\\it asymptotic eigenfunctions}, which are concentrated as much as one wants to a classical trajectory and have a lifetime as long as one wants. These states are directly related to the presence of shell structures in the quantal spectrum of the system. It is argued that the result can be extended to classically chaotic system, at least in the asymptotic regime.

  15. Integrable systems, geometry, and topology

    CERN Document Server

    Terng, Chuu-Lian

    2006-01-01

    The articles in this volume are based on lectures from a program on integrable systems and differential geometry held at Taiwan's National Center for Theoretical Sciences. As is well-known, for many soliton equations, the solutions have interpretations as differential geometric objects, and thereby techniques of soliton equations have been successfully applied to the study of geometric problems. The article by Burstall gives a beautiful exposition on isothermic surfaces and their relations to integrable systems, and the two articles by Guest give an introduction to quantum cohomology, carry out explicit computations of the quantum cohomology of flag manifolds and Hirzebruch surfaces, and give a survey of Givental's quantum differential equations. The article by Heintze, Liu, and Olmos is on the theory of isoparametric submanifolds in an arbitrary Riemannian manifold, which is related to the n-wave equation when the ambient manifold is Euclidean. Mukai-Hidano and Ohnita present a survey on the moduli space of ...

  16. Advanced Integrated Power Systems (AIPS)

    Science.gov (United States)

    2012-10-08

    microgrid environment. Fault current distribution during islanded and grid-connected operation was the primary issue investigated. Their paper...describes an earthing or grounding system design for integration into a microgrid . Their design would rely on over current sensing technologies that are...were compared to actual data to verify the validity of the model. The model can now be used with microgrid models to simulate control and response

  17. Integrated nonthermal treatment system study

    Energy Technology Data Exchange (ETDEWEB)

    Biagi, C.; Bahar, D.; Teheranian, B.; Vetromile, J. [Morrison Knudsen Corp. (United States); Quapp, W.J. [Nuclear Metals (United States); Bechtold, T.; Brown, B.; Schwinkendorf, W. [Lockheed Martin Idaho Technologies Co., Idaho Falls, ID (United States); Swartz, G. [Swartz and Associates (United States)

    1997-01-01

    This report presents the results of a study of nonthermal treatment technologies. The study consisted of a systematic assessment of five nonthermal treatment alternatives. The treatment alternatives consist of widely varying technologies for safely destroying the hazardous organic components, reducing the volume, and preparing for final disposal of the contact-handled mixed low-level waste (MLLW) currently stored in the US Department of Energy complex. The alternatives considered were innovative nonthermal treatments for organic liquids and sludges, process residue, soil and debris. Vacuum desorption or various washing approaches are considered for treatment of soil, residue and debris. Organic destruction methods include mediated electrochemical oxidation, catalytic wet oxidation, and acid digestion. Other methods studied included stabilization technologies and mercury separation of treatment residues. This study is a companion to the integrated thermal treatment study which examined 19 alternatives for thermal treatment of MLLW waste. The quantities and physical and chemical compositions of the input waste are based on the inventory database developed by the US Department of Energy. The Integrated Nonthermal Treatment Systems (INTS) systems were evaluated using the same waste input (2,927 pounds per hour) as the Integrated Thermal Treatment Systems (ITTS). 48 refs., 68 figs., 37 tabs.

  18. Advanced integrated enhanced vision systems

    Science.gov (United States)

    Kerr, J. R.; Luk, Chiu H.; Hammerstrom, Dan; Pavel, Misha

    2003-09-01

    In anticipation of its ultimate role in transport, business and rotary wing aircraft, we clarify the role of Enhanced Vision Systems (EVS): how the output data will be utilized, appropriate architecture for total avionics integration, pilot and control interfaces, and operational utilization. Ground-map (database) correlation is critical, and we suggest that "synthetic vision" is simply a subset of the monitor/guidance interface issue. The core of integrated EVS is its sensor processor. In order to approximate optimal, Bayesian multi-sensor fusion and ground correlation functionality in real time, we are developing a neural net approach utilizing human visual pathway and self-organizing, associative-engine processing. In addition to EVS/SVS imagery, outputs will include sensor-based navigation and attitude signals as well as hazard detection. A system architecture is described, encompassing an all-weather sensor suite; advanced processing technology; intertial, GPS and other avionics inputs; and pilot and machine interfaces. Issues of total-system accuracy and integrity are addressed, as well as flight operational aspects relating to both civil certification and military applications in IMC.

  19. Agents in an Integrated System Architecture

    DEFF Research Database (Denmark)

    Hartvig, Susanne C; Andersen, Tom

    1997-01-01

    This paper presents research findings from development of an expert system and its integration into an integrated environment. Expert systems has proven hard to integrate because of their interactive nature. A prototype environment was developed using new integration technologies, and research...... findings concerning the use of OLE technology to integrate stand alone applications are discussed. The prototype shows clear advantages of using OLE technology when developing integrated environments....

  20. An integrable Hamiltonian hierarchy and associated integrable couplings system

    Institute of Scientific and Technical Information of China (English)

    Chen Xiao-Hong; Xia Tie-Cheng; Zhu Lian-Cheng

    2007-01-01

    This paper establishes a new isospectral problem. By making use of the Tu scheme, a new integrable system is obtained. It gives integrable couplings of the system obtained. Finally, the Hamiltonian form of a binary symmetric constrained flow of the system obtained is presented.

  1. 75 FR 1363 - Integrated System Power Rates

    Science.gov (United States)

    2010-01-11

    ... Southwestern Power Administration Integrated System Power Rates AGENCY: Southwestern Power Administration, DOE... System pursuant to the following Integrated System Rate Schedules: Rate Schedule P-09, Wholesale Rates...) Administrator has determined based on the 2009 Integrated System Current Power Repayment Study, that...

  2. Coal-fuelled systems for peaking power with 100% CO2 capture through integration of solid oxide fuel cells with compressed air energy storage

    Science.gov (United States)

    Nease, Jake; Adams, Thomas A.

    2014-04-01

    In this study, a coal-fuelled integrated solid oxide fuel cell (SOFC) and compressed air energy storage (CAES) system in a load-following power production scenario is discussed. Sixteen SOFC-based plants with optional carbon capture and sequestration (CCS) and syngas shifting steps are simulated and compared to a state-of-the-art supercritical pulverised coal (SCPC) plant. Simulations are performed using a combination of MATLAB and Aspen Plus v7.3. It was found that adding CAES to a SOFC-based plant can provide load-following capabilities with relatively small effects on efficiencies (1-2% HHV depending on the system configuration) and levelized costs of electricity (∼0.35 ¢ kW-1 h-1). The load-following capabilities, as measured by least-squares metrics, show that this system may utilize coal and achieve excellent load-tracking that is not adversely affected by the inclusion of CCS. Adding CCS to the SOFC/CAES system reduces measurable direct CO2 emission to zero. A seasonal partial plant shutdown schedule is found to reduce fuel consumption by 9.5% while allowing for cleaning and maintenance windows for the SOFC stacks without significantly affecting the performance of the system (∼1% HHV reduction in efficiency). The SOFC-based systems with CCS are found to become economically attractive relative to SCPC above carbon taxes of 22 ton-1.

  3. Integrated risk information system (IRIS)

    Energy Technology Data Exchange (ETDEWEB)

    Tuxen, L. [Environmental Protection Agency, Washington, DC (United States)

    1990-12-31

    The Integrated Risk Information System (IRIS) is an electronic information system developed by the US Environmental Protection Agency (EPA) containing information related to health risk assessment. IRIS is the Agency`s primary vehicle for communication of chronic health hazard information that represents Agency consensus following comprehensive review by intra-Agency work groups. The original purpose for developing IRIS was to provide guidance to EPA personnel in making risk management decisions. This original purpose for developing IRIS was to guidance to EPA personnel in making risk management decisions. This role has expanded and evolved with wider access and use of the system. IRIS contains chemical-specific information in summary format for approximately 500 chemicals. IRIS is available to the general public on the National Library of Medicine`s Toxicology Data Network (TOXNET) and on diskettes through the National Technical Information Service (NTIS).

  4. Integrability of some generalized Lotka - Volterra systems

    Energy Technology Data Exchange (ETDEWEB)

    Bountis, T.C.; Bier, M.; Hijmans, J.

    1983-08-08

    Several integrable systems of nonlinear ordinary differential equations of the Lotka-Volterra type are identified by the Painleve property and completely integrated. One such integrable case of N first order ode's is found, with N - 2 free parameters and N arbitrary. The concept of integrability of a general dynamical system, not necessarily derived from a hamiltonian, is also discussed.

  5. DIRECT INTEGRATION METHODS WITH INTEGRAL MODEL FOR DYNAMIC SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    吕和祥; 于洪洁; 裘春航

    2001-01-01

    A new approach which is a direct integration method with integral model ( DIM IM) to solve dynamic governing equations is presented. The governing equations are integrated into the integral equations. An algorithm with explicit and predict-correct and selfstarting and fourth-order accuracy to integrate the integral equations is given.Theoretical analysis and numerical examples show that DIM-IM discribed in this paper suitable for strong nonlinear and non-conservative system have higher accuracy than central difference, Houbolt , Newmark and Wilson- Theta methods.

  6. Slimplectic Integrators: Variational Integrators for General Nonconservative Systems

    CERN Document Server

    Tsang, David; Stein, Leo C; Turner, Alec

    2015-01-01

    Symplectic integrators are widely used for long-term integration of conservative astrophysical problems due to their ability to preserve the constants of motion; however, they cannot in general be applied in the presence of nonconservative interactions. In this Letter, we develop the "slimplectic" integrator, a new type of numerical integrator that shares many of the benefits of traditional symplectic integrators yet is applicable to general nonconservative systems. We utilize a fixed time-step variational integrator formalism applied to the principle of stationary nonconservative action developed in Galley, 2013; Galley, Tsang & Stein, 2014. As a result, the generalized momenta and energy (Noether current) evolutions are well-tracked. We discuss several example systems, including damped harmonic oscillators, Poynting-Robertson drag, and gravitational radiation reaction, by utilizing our new publicly available code to demonstrate the slimplectic integrator algorithm. Slimplectic integrators are well-suite...

  7. DORIS system and integrity survey

    Science.gov (United States)

    Jayles, C.; Chauveau, J. P.; Didelot, F.; Auriol, A.; Tourain, C.

    2016-12-01

    DORIS, as other techniques for space geodesy (SLR, VLBI, GPS) has regularly progressed to meet the ever increasing needs of the scientific community in oceanography, geodesy or geophysics. Over the past 10 years, a particular emphasis has been placed on integrity monitoring of the system, which has contributed to the enhancement of the overall availability and quality of DORIS data products. A high level of monitoring is now provided by a centralized control of the whole system, including the global network of beacons and the onboard instruments, which perform a constant end-to-end survey. At first signs of any unusual behavior, a dedicated team is activated with well-established tools to investigate, to anticipate and to contain the impact of any potential failures. The procedure has increased the availability of DORIS beacons to 90%. The core topic of this article is to demonstrate that DORIS has implemented a high-level integrity control of its data. Embedded in the DORIS receiver, DIODE (DORIS Immediate Orbit Determination) is a Real-Time On-Board Orbit Determination software. Its accuracy has also been dramatically improved when compared to Precise Orbit Ephemeris (P.O.E.), down to 2.7 cm RMS on Jason-2, 3.0 cm on Saral and 3.3 cm on CryoSat-2. Specific quality indices were derived from the DIODE-based Kalman filters and are used to monitor network and system performance. This paper covers the definition of these indices and how the reliability and the reactiveness to incidents or anomalies of the system are improved. From these indices, we have provided detailed diagnostic information about the DORIS system, which is available in real-time, on-board each DORIS satellite. Using these capabilities, we have developed real-time functions that give an immediate diagnosis of the status of key components in the DORIS system. The Near-Real Time navigation system was improved and can distinguish and handle both satellite events and beacon anomalies. The next missions

  8. Progress Letter Report on Bending Fatigue Test System Development for Spent Nuclear Fuel Vibration Integrity Study (Out-of-cell fatigue testing development - Task 2.4)

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Jy-An John [ORNL; Wang, Hong [ORNL; Cox, Thomas S [ORNL; Baldwin, Charles A [ORNL; Bevard, Bruce Balkcom [ORNL

    2013-08-01

    Vibration integrity of high burn-up spent nuclear fuel in transportation remains to be a critical component of US nuclear waste management system. The structural evaluation of package for spent fuel transportation eventually will need to see if the content or spent fuel is in a subcritical condition. However, a system for testing and characterizing such spent fuel is still lacking mainly due to the complication involved with dealing radioactive specimens in a hot cell environment. Apparently, the current state-of-the-art in spent fuel research and development is quite far away from the delivery of reliable mechanical property data for the assessment of spent fuels in the transport package evaluation. Under the sponsorship of US NRC, ORNL has taken the challenge in developing a robust testing system for spent fuel in hot cell. An extensive literature survey was carried out and unique requirements of such testing system were identified. The U-frame setup has come to the top among various designs examined for reverse bending fatigue test of spent fuel rod. The U-frame has many features that deserve mentioned here: Easy to install spent fuel rod in test; Less linkages than in conventional bending test setup such as three-point or four-point bending; Target the failure mode relevant to the fracture of spent fuel rod in transportation by focusing on pure bending; The continuous calibrations and modifications resulted in the third generation (3G) U-frame testing setup. Rigid arms are split along the LBB axis at rod sample ends. For each arm, this results in a large arm body and an end piece. Mating halves of bushings were modified into two V-shaped surfaces on which linear roller bearings (LRB) are embedded. The rod specimen is installed into the test fixture through opening and closing slide end-pieces. The 3G apparently has addressed major issues of setup identified in the previous stage and been proven to be eligible to be further pursued in this project. On the other

  9. Integrated system for seismic evaluations

    Energy Technology Data Exchange (ETDEWEB)

    Xu, J.; Philippacopoulos, A.J.; Miller, C.A.; Costantino, C.J.; Graves, H.

    1989-01-01

    This paper describes the various features of the Seismic Module of the CARES system (Computer Analysis for Rapid Evaluation of Structures). This system was developed by Brookhaven National Laboratory (BNL) for the US Nuclear Regulatory Commission to perform rapid evaluations of structural behavior and capability of nuclear power plant facilities. The CARES is structured in a modular format. Each module performs a specific type of analysis i.e., static or dynamic, linear or nonlinear, etc. This paper describes the features of the Seismic Module in particular. The development of the Seismic Module of the CARES system is based on an approach which incorporates all major aspects of seismic analysis currently employed by the industry into an integrated system that allows for carrying out interactively computations of structural response to seismic motions. The code operates on a PC computer system and has multi-graphics capabilities. It has been designed with user friendly features and it allows for interactive manipulation of various analysis phases during the seismic design process. The capabilities of the seismic module include (a) generation of artificial time histories compatible with given design ground response spectra, (b) development of Power Spectral Density (PSD) functions associated with the seismic input, (c) deconvolution analysis using vertically propagating shear waves through a given soil profile, and (d) development of in-structure response spectra or corresponding PSD's. It should be pointed out that these types of analyses can also be performed individually by using available computer codes such as FLUSH, SAP, etc. The uniqueness of the CARES, however, lies on its ability to perform all required phases of the seismic analysis in an integrated manner. 5 refs., 6 figs.

  10. Polycation-mediated integrated cell death processes

    DEFF Research Database (Denmark)

    Parhamifar, Ladan; Andersen, Helene; Wu, Linping

    2014-01-01

    standard. PEIs are highly efficient transfectants, but depending on their architecture and size they induce cytotoxicity through different modes of cell death pathways. Here, we briefly review dynamic and integrated cell death processes and pathways, and discuss considerations in cell death assay design...

  11. Robust integral stabilization of regular linear systems

    Institute of Scientific and Technical Information of China (English)

    XU Chengzheng; FENG Dexing

    2004-01-01

    We consider regular systems with control and observation. We prove some necessary and sufficient condition for an exponentially stable regular system to admit an integral stabilizing controller. We propose also some robust integral controllers when they exist.

  12. Quantization of noncommutative completely integrable Hamiltonian systems

    Energy Technology Data Exchange (ETDEWEB)

    Giachetta, G. [Department of Mathematics and Informatics, University of Camerino, 62032 Camerino (Italy); Mangiarotti, L. [Department of Mathematics and Informatics, University of Camerino, 62032 Camerino (Italy); Sardanashvily, G. [Department of Theoretical Physics, Moscow State University, 117234 Moscow (Russian Federation)]. E-mail: gennadi.sardanashvily@unicam.it

    2007-02-26

    Integrals of motion of a Hamiltonian system need not commute. The classical Mishchenko-Fomenko theorem enables one to quantize a noncommutative completely integrable Hamiltonian system around its invariant submanifold as the Abelian one.

  13. Approaches in integrative bioinformatics towards the virtual cell

    CERN Document Server

    Chen, Ming

    2014-01-01

    Approaches in Integrative Bioinformatics provides a basic introduction to biological information systems, as well as guidance for the computational analysis of systems biology. This book also covers a range of issues and methods that reveal the multitude of omics data integration types and the relevance that integrative bioinformatics has today. Topics include biological data integration and manipulation, modeling and simulation of metabolic networks, transcriptomics and phenomics, and virtual cell approaches, as well as a number of applications of network biology. It helps to illustrat

  14. Geometric transitions and integrable systems

    Energy Technology Data Exchange (ETDEWEB)

    Diaconescu, D.-E. [New High Energy Theory Center, Rutgers University, 126 Frelinghuysen Road, Piscataway, NJ 08854 (United States)]. E-mail: duiliu@physics.rutgers.edu; Dijkgraaf, R. [Institute for Theoretical Physics and KdV Institute for Mathematics, University of Amsterdam, Valckenierstraat 65, 1018 XE Amsterdam (Netherlands); Donagi, R. [Department of Mathematics, University of Pennsylvania, David Rittenhouse Laboratory, 209 South 33rd Street, Philadelphia, PA 19104-6395 (United States); Hofman, C. [The Weizmann Institute for Science, Department of Particle Physics, Herzl Street 2, 76100 Rehovot (Israel); Pantev, T. [Department of Mathematics, University of Pennsylvania, David Rittenhouse Laboratory, 209 South 33rd Street, Philadelphia, PA 19104-6395 (United States)

    2006-09-25

    We consider B-model large N duality for a new class of noncompact Calabi-Yau spaces modeled on the neighborhood of a ruled surface in a Calabi-Yau threefold. The closed string side of the transition is governed at genus zero by an A{sub 1} Hitchin integrable system on a genus g Riemann surface {sigma}. The open string side is described by a holomorphic Chern-Simons theory which reduces to a generalized matrix model in which the eigenvalues lie on the compact Riemann surface {sigma}. We show that the large N planar limit of the generalized matrix model is governed by the same A{sub 1} Hitchin system therefore proving genus zero large N duality for this class of transitions.

  15. Geometric transitions and integrable systems

    CERN Document Server

    Diaconescu, D E; Dijkgraaf, R; Hofman, C M; Pantev, T; Diaconescu, Duiliu-Emanuel; Donagi, Ron; Dijkgraaf, Robbert; Hofman, Christiaan; Pantev, Tony

    2005-01-01

    We consider {\\bf B}-model large $N$ duality for a new class of noncompact Calabi-Yau spaces modeled on the neighborhood of a ruled surface in a Calabi-Yau threefold. The closed string side of the transition is governed at genus zero by an $A_1$ Hitchin integrable system on a genus $g$ Riemann surface $\\Sigma$. The open string side is described by a holomorphic Chern-Simons theory which reduces to a generalized matrix model in which the eigenvalues lie on the compact Riemann surface $\\Sigma$. We show that the large $N$ planar limit of the generalized matrix model is governed by the same $A_1$ Hitchin system therefore proving genus zero large $N$ duality for this class of transitions.

  16. Geometric transitions and integrable systems

    Science.gov (United States)

    Diaconescu, D.-E.; Dijkgraaf, R.; Donagi, R.; Hofman, C.; Pantev, T.

    2006-09-01

    We consider B-model large N duality for a new class of noncompact Calabi-Yau spaces modeled on the neighborhood of a ruled surface in a Calabi-Yau threefold. The closed string side of the transition is governed at genus zero by an A Hitchin integrable system on a genus g Riemann surface Σ. The open string side is described by a holomorphic Chern-Simons theory which reduces to a generalized matrix model in which the eigenvalues lie on the compact Riemann surface Σ. We show that the large N planar limit of the generalized matrix model is governed by the same A Hitchin system therefore proving genus zero large N duality for this class of transitions.

  17. Integrated roof wind energy system

    Directory of Open Access Journals (Sweden)

    Moonen S.P.G.

    2012-10-01

    Full Text Available Wind is an attractive renewable source of energy. Recent innovations in research and design have reduced to a few alternatives with limited impact on residential construction. Cost effective solutions have been found at larger scale, but storage and delivery of energy to the actual location it is used, remain a critical issue. The Integrated Roof Wind Energy System is designed to overcome the current issues of urban and larger scale renewable energy system. The system is built up by an axial array of skewed shaped funnels that make use of the Venturi Effect to accelerate the wind flow. This inventive use of shape and geometry leads to a converging air capturing inlet to create high wind mass flow and velocity toward a vertical-axis wind turbine in the top of the roof for generation of a relatively high amount of energy. The methods used in this overview of studies include an array of tools from analytical modelling, PIV wind tunnel testing, and CFD simulation studies. The results define the main design parameters for an efficient system, and show the potential for the generation of high amounts of renewable energy with a novel and effective system suited for the built environment.

  18. Integrated roof wind energy system

    Science.gov (United States)

    Suma, A. B.; Ferraro, R. M.; Dano, B.; Moonen, S. P. G.

    2012-10-01

    Wind is an attractive renewable source of energy. Recent innovations in research and design have reduced to a few alternatives with limited impact on residential construction. Cost effective solutions have been found at larger scale, but storage and delivery of energy to the actual location it is used, remain a critical issue. The Integrated Roof Wind Energy System is designed to overcome the current issues of urban and larger scale renewable energy system. The system is built up by an axial array of skewed shaped funnels that make use of the Venturi Effect to accelerate the wind flow. This inventive use of shape and geometry leads to a converging air capturing inlet to create high wind mass flow and velocity toward a vertical-axis wind turbine in the top of the roof for generation of a relatively high amount of energy. The methods used in this overview of studies include an array of tools from analytical modelling, PIV wind tunnel testing, and CFD simulation studies. The results define the main design parameters for an efficient system, and show the potential for the generation of high amounts of renewable energy with a novel and effective system suited for the built environment.

  19. 76 FR 48159 - Integrated System Power Rates

    Science.gov (United States)

    2011-08-08

    ... Southwestern Power Administration Integrated System Power Rates AGENCY: Southwestern Power Administration, DOE... facilities. The Administrator has developed proposed Integrated System rates, which are supported by a rate... 24 projects are repaid via revenues received under the Integrated System rates, as are those...

  20. A Preliminary Shielding Study on the Integrated Operation Verification System in the Head-End Hot-Cell of the Pyro-processing

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jinhwam; Kim, Yewon; Park, Se-Hwan; Ahn, Seong-Kyu; Cho, Gyuseong [KAIST, Daejeon (Korea, Republic of)

    2016-10-15

    Nuclear power accounts for more than 30 percent of power production in Korea. Its significance has annually been increased. Disposal spent fuel containing uranium, transuranic elements, and fission products is unavoidable byproduct of nuclear power production. it is recognized that finding appropriate sites for interim storage of disposal spent fuel is not easy because isolated sites should be required. Pyro-processing technology, Pyro-processing should be operated under high radiation environment in hot-cell structures. Because of this reason, all workers should be unauthorized to access inside the hot-cell areas under any circumstances except for acceptable dose verification and a normal operation should be remotely manipulated. For the reliable normal operation of pyroprocessing, it is noted that an evaluation of the space dose distribution in the hot-cell environments is necessary in advance in order to determine which technologies or instruments can be utilized on or near the process as the Integrated Operation Verification System (IOVS) is measured. Not like the electroreduction and electro-refining hot-cells, the head-end hot-cell equips Camera Radiation Detector (CRD) in which plutonium is securely measured and monitored for the safeguard of the pyro-processing. Results have been obtained using F2 surface tally in order to observe the magnitude of the gamma-ray and neutron flux which pass through the surface of the process cell. Furthermore, T-mesh tally has also been used to obtain the space dose distribution in the headend hot-cell. The hot-cell was divided into 7,668 cells in which each dimension was 1 x 1 x 1m for the T-mesh tally. To determine the position of the CRD and the surveillance camera, divergent approaches were required. Because the purpose of the CRD which contains a gamma-ray detector and a neutron detector is to identify the material composition as the process proceeds, the position in which detectable flux is exposed is required, whereas

  1. Intelligent systems technology infrastructure for integrated systems

    Science.gov (United States)

    Lum, Henry

    1991-01-01

    A system infrastructure must be properly designed and integrated from the conceptual development phase to accommodate evolutionary intelligent technologies. Several technology development activities were identified that may have application to rendezvous and capture systems. Optical correlators in conjunction with fuzzy logic control might be used for the identification, tracking, and capture of either cooperative or non-cooperative targets without the intensive computational requirements associated with vision processing. A hybrid digital/analog system was developed and tested with a robotic arm. An aircraft refueling application demonstration is planned within two years. Initially this demonstration will be ground based with a follow-on air based demonstration. System dependability measurement and modeling techniques are being developed for fault management applications. This involves usage of incremental solution/evaluation techniques and modularized systems to facilitate reuse and to take advantage of natural partitions in system models. Though not yet commercially available and currently subject to accuracy limitations, technology is being developed to perform optical matrix operations to enhance computational speed. Optical terrain recognition using camera image sequencing processed with optical correlators is being developed to determine position and velocity in support of lander guidance. The system is planned for testing in conjunction with Dryden Flight Research Facility. Advanced architecture technology is defining open architecture design constraints, test bed concepts (processors, multiple hardware/software and multi-dimensional user support, knowledge/tool sharing infrastructure), and software engineering interface issues.

  2. Mechatronics in fuel cell systems

    Energy Technology Data Exchange (ETDEWEB)

    Stefanopoulou, Anna G.; Kyungwon Suh [Mechanical Engineering Department, University of Michigan, 1231 Beal Avenue, Ann Arbor, MI 48109, (United States)

    2007-03-15

    Power generation from fuel cells (FCs) requires the integration of chemical, fluid, mechanical, thermal, electrical, and electronic subsystems. This integration presents many challenges and opportunities in the mechatronics field. This paper highlights important design issues and poses problems that require mechatronics solutions. The paper begins by describing the process of designing a toy school bus powered by hydrogen for an undergraduate student project. The project was an effective and rewarding educational activity that revealed complex systems issues associated with FC technology. (Author)

  3. Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.

    Science.gov (United States)

    Bottai, Daria; Di Luca, Mariagrazia; Majlessi, Laleh; Frigui, Wafa; Simeone, Roxane; Sayes, Fadel; Bitter, Wilbert; Brennan, Michael J; Leclerc, Claude; Batoni, Giovanna; Campa, Mario; Brosch, Roland; Esin, Semih

    2012-03-01

    The chromosome of Mycobacterium tuberculosis encodes five type VII secretion systems (ESX-1-ESX-5). While the role of the ESX-1 and ESX-3 systems in M. tuberculosis has been elucidated, predictions for the function of the ESX-5 system came from data obtained in Mycobacterium marinum, where it transports PPE and PE_PGRS proteins and modulates innate immune responses. To define the role of the ESX-5 system in M. tuberculosis, in this study, we have constructed five M. tuberculosis H37Rv ESX-5 knockout/deletion mutants, inactivating eccA(5), eccD(5), rv1794 and esxM genes or the ppe25-pe19 region. Whereas the Mtbrv1794ko displayed no obvious phenotype, the other four mutants showed defects in secretion of the ESX-5-encoded EsxN and PPE41, a representative member of the large PPE protein family. Strikingly, the MtbeccD(5) ko mutant also showed enhanced sensitivity to detergents and hydrophilic antibiotics. When the virulence of the five mutants was evaluated, the MtbeccD(5) ko and MtbΔppe25-pe19 mutants were found attenuated both in macrophages and in the severe combined immune-deficient mouse infection model. Altogether these findings indicate an essential role of ESX-5 for transport of PPE proteins, cell wall integrity and full virulence of M. tuberculosis, thereby opening interesting new perspectives for the study of this human pathogen.

  4. Systems Integration Challenges for a National Space Launch System

    Science.gov (United States)

    May, Todd A.

    2011-01-01

    System Integration was refined through the complexity and early failures experienced in rocket flight. System Integration encompasses many different viewpoints of the system development. System Integration must ensure consistency in development and operations activities. Human Space Flight tends toward large, complex systems. Understanding the system fs operational and use context is the guiding principle for System Integration: (1) Sizeable costs can be driven into systems by not fully understanding context (2). Adhering to the system context throughout the system fs life cycle is essential to maintaining efficient System Integration. System Integration exists within the System Architecture. Beautiful systems are simple in use and operation -- Block upgrades facilitate manageable steps in functionality evolution. Effective System Integration requires a stable system concept. Communication is essential to system simplicity

  5. Validation of an integrated staging system toward improved prognostication of patients with localized renal cell carcinoma in an international population.

    NARCIS (Netherlands)

    Han, K.R.; Bleumer, I.; Pantuck, A.J.; Kim, H.L.; Dorey, F.J.; Janzen, N.K.; Zisman, A.; Dinney, C.P.; Wood, C.G.; Swanson, D.A.; Said, J.W.; Figlin, R.A.; Mulders, P.F.A.; Belldegrun, A.S.

    2003-01-01

    PURPOSE: Outcome prediction for patients with renal cell carcinoma is based on a combination of factors. In this study a previously published clinical outcome algorithm based on 1997 T stage, Fuhrman grade and performance score is validated using an international database. MATERIALS AND METHODS: A t

  6. INTEGRATION OF ENVIRONMENTAL MANAGEMENT SYSTEM

    Directory of Open Access Journals (Sweden)

    Tomescu Ada Mirela

    2012-07-01

    Full Text Available The relevance of management as significant factor of business activity can be established on various management systems. These will help to obtain, organise, administrate, evaluate and control particulars: information, quality, environmental protection, health and safety, various resources (time, human, finance, inventory etc. The complexity of nowadays days development, forced us to think ‘integrated’. Sustainable development principles require that environment management policies and practices are not good in themselves but also integrate with all other environmental objectives, and with social and economic development objectives. The principles of sustainable development involve that environment management policies and practices. These are not sound in them-self but also integrate with all other environmental objectives, and with social and economic development objectives. Those objectives were realized, and followed by development of strategies to effects the objective of sustainable development. Environmental management should embrace recent change in the area of environmental protection, and suit the recently regulations of the field -entire legal and economic, as well as perform management systems to meet the requirements of the contemporary model for economic development. These changes are trailed by abandon the conventional approach of environmental protection and it is replaced by sustainable development (SD. The keys and the aims of Cleaner Productions (CP are presented being implemented in various companies as a non-formalised environmental management system (EMS. This concept is suggested here as a proper model for practice where possible environmental harmful technologies are used -e.g. Rosia Montana. Showing the features and the power of CP this paper is a signal oriented to involve the awareness of policy-makers and top management of diverse Romanian companies. Many companies in European countries are developing

  7. Energy Systems Integration: Demonstrating Distributed Resource Communications

    Energy Technology Data Exchange (ETDEWEB)

    2017-01-01

    Overview fact sheet about the Electric Power Research Institute (EPRI) and Schneider Electric Integrated Network Testbed for Energy Grid Research and Technology Experimentation (INTEGRATE) project at the Energy Systems Integration Facility. INTEGRATE is part of the U.S. Department of Energy's Grid Modernization Initiative.

  8. A potential integration method for Birkhoffian system

    Institute of Scientific and Technical Information of China (English)

    Hu Chu-Le; Xie Jia-Fang

    2008-01-01

    This paper is intended to apply the potential integration method to the differential equations of the Birkhoffian system.The method is that,for a given Birkhoffian system,its diffcrential equations are first rewritten as 2n first-order differential equations.Secondly,the corresponding partial differential equations are obtained by potential integration method and the solution is expressed as a complete integral.Finally, the integral of the system is obtained.

  9. Integrated Standardization and Systems Engineering Management

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Integrated standardization is one of the fundamenta l forms of modern standardization. It is the combination of system science and the content of standardization. The development of system science has provided theo retic foundation and precondition for integrated standardization. The relevant r esearch on integrated standardization and system engineering illustrate that int egrated standardization is a advanced method which presented with the developmen t of modern science and technology . Integrated st...

  10. Disposable self-support paper-based multi-anode microbial fuel cell (PMMFC) integrated with power management system (PMS) as the real time "shock" biosensor for wastewater.

    Science.gov (United States)

    Xu, Zhiheng; Liu, Yucheng; Williams, Isaiah; Li, Yan; Qian, Fengyu; Zhang, Hui; Cai, Dingyi; Wang, Lei; Li, Baikun

    2016-11-15

    A paper-based multi-anode microbial fuel cell (PMMFC) integrated with power management system (PMS) was developed as a disposable self-support real-time "shock" biosensor for wastewater. PMMFCs were examined at three types of shocks (chromium, hypochlorite and acetate) in a batch-mode chamber, and exhibited various responses to shock types and concentrations. The power output of PMMFC sensor was four times as the carbon cloth (CC)-based MFCs, indicating the advantage of paper-based anode for bacterial adhesion. The power output was more sensitive than the voltage output under shocks, and thus preventing the false signals. The simulation of power harvest using PMS indicated that PMMFC could accomplish more frequent data transmission than single-anode MFCs (PSMFC) and CC anode MFCs (CCMMFC), making the self-support wastewater monitor and data transmission possible. Compared with traditional MFC sensors, PMMFCs integrated with PMS exhibit the distinct advantages of tight paper-packed structure, short acclimation period, high power output, and high sensitivity to a wide range of shocks, posing a great potential as "disposable self-support shock sensor" for real time in situ monitoring of wastewater quality.

  11. Integrated solar energy system optimization

    Science.gov (United States)

    Young, S. K.

    1982-11-01

    The computer program SYSOPT, intended as a tool for optimizing the subsystem sizing, performance, and economics of integrated wind and solar energy systems, is presented. The modular structure of the methodology additionally allows simulations when the solar subsystems are combined with conventional technologies, e.g., a utility grid. Hourly energy/mass flow balances are computed for interconnection points, yielding optimized sizing and time-dependent operation of various subsystems. The program requires meteorological data, such as insolation, diurnal and seasonal variations, and wind speed at the hub height of a wind turbine, all of which can be taken from simulations like the TRNSYS program. Examples are provided for optimization of a solar-powered (wind turbine and parabolic trough-Rankine generator) desalinization plant, and a design analysis for a solar powered greenhouse.

  12. Integrated delivery systems. Evolving oligopolies.

    Science.gov (United States)

    Malone, T A

    1998-01-01

    The proliferation of Integrated Delivery Systems (IDSs) in regional health care markets has resulted in the movement of these markets from a monopolistic competitive model of behavior to an oligopoly. An oligopoly is synonymous with competition among the few, as a small number of firms supply a dominant share of an industry's total output. The basic characteristics of a market with competition among the few are: (1) A mutual interdependence among the actions and behaviors of competing firms; (2) competition tends to rely on the differentiation of products; (3) significant barriers to entering the market exist; (4) the demand curve for services may be kinked; and (5) firms can benefit from economies of scale. An understanding of these characteristics is essential to the survival of IDSs as regional managed care markets mature.

  13. SENSORIMOTOR INTEGRATION BY CORTICOSPINAL SYSTEM

    Directory of Open Access Journals (Sweden)

    Yunuen eMoreno-López

    2016-03-01

    Full Text Available The corticospinal (CS tract is a complex system which targets several areas of the spinal cord. In particular, the CS descending projection plays a major role in motor command, which results from direct and indirect control of spinal cord pre-motor interneurons as well as motoneurons. But in addition, this system is also involved in a selective and complex modulation of sensory feedback. Despite recent evidence confirms that CS projections drive distinct segmental neural circuits that are part of the sensory and pre-motor pathways, little is known about the spinal networks engaged by the corticospinal tract, the organization of CS projections, the intracortical microcircuitry, and the synaptic interactions in the sensorimotor cortex that may encode different cortical outputs to the spinal cord. Here is stressed the importance of integrated approaches for the study of sensorimotor function of CS system, in order to understand the functional compartmentalization and hierarchical organization of layer 5 output neurons, who are key elements for motor control and hence, of behavior.

  14. Advanced integrated solvent extraction systems

    Energy Technology Data Exchange (ETDEWEB)

    Horwitz, E.P.; Dietz, M.L.; Leonard, R.A. [Argonne National Lab., IL (United States)

    1997-10-01

    Advanced integrated solvent extraction systems are a series of novel solvent extraction (SX) processes that will remove and recover all of the major radioisotopes from acidic-dissolved sludge or other acidic high-level wastes. The major focus of this effort during the last 2 years has been the development of a combined cesium-strontium extraction/recovery process, the Combined CSEX-SREX Process. The Combined CSEX-SREX Process relies on a mixture of a strontium-selective macrocyclic polyether and a novel cesium-selective extractant based on dibenzo 18-crown-6. The process offers several potential advantages over possible alternatives in a chemical processing scheme for high-level waste treatment. First, if the process is applied as the first step in chemical pretreatment, the radiation level for all subsequent processing steps (e.g., transuranic extraction/recovery, or TRUEX) will be significantly reduced. Thus, less costly shielding would be required. The second advantage of the Combined CSEX-SREX Process is that the recovered Cs-Sr fraction is non-transuranic, and therefore will decay to low-level waste after only a few hundred years. Finally, combining individual processes into a single process will reduce the amount of equipment required to pretreat the waste and therefore reduce the size and cost of the waste processing facility. In an ongoing collaboration with Lockheed Martin Idaho Technology Company (LMITCO), the authors have successfully tested various segments of the Advanced Integrated Solvent Extraction Systems. Eichrom Industries, Inc. (Darien, IL) synthesizes and markets the Sr extractant and can supply the Cs extractant on a limited basis. Plans are under way to perform a test of the Combined CSEX-SREX Process with real waste at LMITCO in the near future.

  15. Geometry and dynamics of integrable systems

    CERN Document Server

    Matveev, Vladimir

    2016-01-01

    Based on lectures given at an advanced course on integrable systems at the Centre de Recerca Matemàtica in Barcelona, these lecture notes address three major aspects of integrable systems: obstructions to integrability from differential Galois theory; the description of singularities of integrable systems on the basis of their relation to bi-Hamiltonian systems; and the generalization of integrable systems to the non-Hamiltonian settings. All three sections were written by top experts in their respective fields. Native to actual problem-solving challenges in mechanics, the topic of integrable systems is currently at the crossroads of several disciplines in pure and applied mathematics, and also has important interactions with physics. The study of integrable systems also actively employs methods from differential geometry. Moreover, it is extremely important in symplectic geometry and Hamiltonian dynamics, and has strong correlations with mathematical physics, Lie theory and algebraic geometry (including mir...

  16. Roots Air Management System with Integrated Expander

    Energy Technology Data Exchange (ETDEWEB)

    Stretch, Dale [Eaton Corporation, Menomonee Falls, WI (United States); Wright, Brad [Eaton Corporation, Menomonee Falls, WI (United States); Fortini, Matt [Eaton Corporation, Menomonee Falls, WI (United States); Fink, Neal [Ballard Power Systems, Burnaby, BC (Canada); Ramadan, Bassem [Kettering Univ., Flint, MI (United States); Eybergen, William [Eaton Corporation, Menomonee Falls, WI (United States)

    2016-07-06

    PEM fuel cells remain an emerging technology in the vehicle market with several cost and reliability challenges that must be overcome in order to increase market penetration and acceptance. The DOE has identified the lack of a cost effective, reliable, and efficient air supply system that meets the operational requirements of a pressurized PEM 80kW fuel cell as one of the major technological barriers that must be overcome. This project leveraged Roots positive displacement development advancements and demonstrated an efficient and low cost fuel cell air management system. Eaton built upon its P-Series Roots positive displacement design and shifted the peak efficiency making it ideal for use on an 80kW PEM stack. Advantages to this solution include: • Lower speed of the Roots device eliminates complex air bearings present on other systems. • Broad efficiency map of Roots based systems provides an overall higher drive cycle fuel economy. • Core Roots technology has been developed and validated for other transportation applications. Eaton modified their novel R340 Twin Vortices Series (TVS) Roots-type supercharger for this application. The TVS delivers more power and better fuel economy in a smaller package as compared to other supercharger technologies. By properly matching the helix angle with the rotor’s physical aspect ratio, the supercharger’s peak efficiency can be moved to the operating range where it is most beneficial for the application. The compressor was designed to meet the 90 g/s flow at a pressure ratio of 2.5, similar in design to the P-Series 340. A net shape plastic expander housing with integrated motor and compressor was developed to significantly reduce the cost of the system. This integrated design reduced part count by incorporating an overhung expander and motor rotors into the design such that only four bearings and two shafts were utilized.

  17. Integrating fuel cells into science education

    Energy Technology Data Exchange (ETDEWEB)

    Smolensky, J. [Heliocentris Energy Systems, Vancouver, BC (Canada); Colell, H. [heliocentris Energiesysteme GmbH, Berlin (Germany)

    2001-06-01

    The development of quick-to-market commercial products designed primarily for the science and engineering education markets is the niche market of a small, private company based in Germany, called Heliocentris Energiesysteme GmbH. A complete solar hydrogen system, consisting of solar panel module, electrolyser module and fuel cell was the first product marketed by the company in 1997 for the middle school and high school market. For the primary and middle school market, the only product available is the Hyco{sup TM} Hydrogen Model Fuel Cell Car, which demonstrates the potential for a sustainable pollution-free vehicle. Other products designed for secondary school and the vocational and university market are also available and were briefly described. It is believed that the overall growth of the hydrogen market relies in large part on the integration of fuel cell products into education. Partnerships with industry in the promotion of hydrogen technology awareness to the general population has been undertaken by the company. 6 figs.

  18. Design of Incremental Conductance Sliding Mode MPPT Control Applied by Integrated Photovoltaic and Proton Exchange Membrane Fuel Cell System under Various Operating Conditions for BLDC Motor

    Directory of Open Access Journals (Sweden)

    Jehun Hahm

    2015-01-01

    Full Text Available This paper proposes an integrated photovoltaic (PV and proton exchange membrane fuel cell (PEMFC system for continuous energy harvesting under various operating conditions for use with a brushless DC motor. The proposed scheme is based on the incremental conductance (IncCond algorithm combined with the sliding mode technique. Under changing atmospheric conditions, the energy conversion efficiency of a PV array is very low, leading to significant power losses. Consequently, increasing efficiency by means of maximum power point tracking (MPPT is particularly important. To manage such a hybrid system, control strategies need to be established to achieve the aim of the distributed system. Firstly, a Matlab/Simulink based model of the PV and PEMFC is developed and validated, as well as the incremental conductance sliding (ICS MPPT technique; then, different MPPT algorithms are employed to control the PV array under nonuniform temperature and insolation conditions, to study these algorithms effectiveness under various operating conditions. Conventional techniques are easy to implement but produce oscillations at MPP. Compared to these techniques, the proposed technique is more efficient; it produces less oscillation at MPP in the steady state and provides more precise tracking.

  19. Integrated Compliance Information System (ICIS)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The purpose of ICIS is to meet evolving Enforcement and Compliance business needs for EPA and State users by integrating information into a single integrated data...

  20. INTEGRATED LAYOUT DESIGN OF CELLS AND FLOW PATHS

    Institute of Scientific and Technical Information of China (English)

    Li Zhihua; Zhong Yifang; Zhou Ji

    2003-01-01

    The integrated layout problem in manufacturing systems is investigated. An integrated model for concurrent layout design of cells and flow paths is formulated. A hybrid approach combined an enhanced branch-and-bound algorithm with a simulated annealing scheme is proposed to solve this problem. The integrated layout method is applied to re-layout the gear pump shop of a medium-size manufacturer of hydraulic pieces. Results show that the proposed layout method can concurrently provide good solutions of the cell layouts and the flow path layouts.

  1. Bioelectricity generation in an integrated system combining microbial fuel cell and tubular membrane reactor: effects of operation parameters performing a microbial fuel cell-based biosensor for tubular membrane bioreactor.

    Science.gov (United States)

    Wang, Jie; Zheng, Yawen; Jia, Hui; Zhang, Hongwei

    2014-10-01

    A bio-cathode microbial fuel cell (MFC) with tubular membrane was integrated to construct a microbial fuel cell-tubular membrane bioreactor (MFC-TMBR) system, in which the bio-cathode MFC was developed as a biosensor for COD real-time monitoring in TMBR and the performance was analyzed in terms of its current variation caused by operation parameters. With a constant anode potential, the effect of HRT demonstrated that higher rate of mass transport increased the response of the system. The system was further explored an inverse relationship between TMP and current peak by using EPS concentration under the different MLSS concentration. The sensor output had a linear relationship with COD up to 1000mg/L (regression coefficient, R(2)=0.97) and MLSS (regression coefficient, R(2)=0.94). The simple and compact bio-cathode MFC biosensor for TMBR using MFC-TMBR integrated system showed promising potential for direct and economical COD online monitoring, and provided an opportunity to widen the application of MFC-based biosensor. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. “SLIMPLECTIC” INTEGRATORS: VARIATIONAL INTEGRATORS FOR GENERAL NONCONSERVATIVE SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    Tsang, David; Turner, Alec [Department of Physics, McGill University, Montreal, QC H3A 2T8 (Canada); Galley, Chad R. [Theoretical Astrophysics, Walter Burke Institute for Theoretical Physics, California Institute of Technology, Pasadena, CA 91125 (United States); Stein, Leo C., E-mail: dtsang@physics.mcgill.ca [Center for Radiophysics and Space Research, Cornell University, Ithaca, NY 14853 (United States)

    2015-08-10

    Symplectic integrators are widely used for long-term integration of conservative astrophysical problems due to their ability to preserve the constants of motion; however, they cannot in general be applied in the presence of nonconservative interactions. In this Letter, we develop the “slimplectic” integrator, a new type of numerical integrator that shares many of the benefits of traditional symplectic integrators yet is applicable to general nonconservative systems. We utilize a fixed-time-step variational integrator formalism applied to the principle of stationary nonconservative action developed in Galley et al. As a result, the generalized momenta and energy (Noether current) evolutions are well-tracked. We discuss several example systems, including damped harmonic oscillators, Poynting–Robertson drag, and gravitational radiation reaction, by utilizing our new publicly available code to demonstrate the slimplectic integrator algorithm. Slimplectic integrators are well-suited for integrations of systems where nonconservative effects play an important role in the long-term dynamical evolution. As such they are particularly appropriate for cosmological or celestial N-body dynamics problems where nonconservative interactions, e.g., gas interactions or dissipative tides, can play an important role.

  3. Ares I Integrated Vehicle System Safety Team

    Science.gov (United States)

    Wetherholt, Jon; McNairy, Lisa; Shackelford, Carla

    2009-01-01

    Complex systems require integrated analysis teams which sometimes are divided into subsystem teams. Proper division of the analysis in to subsystem teams is important. Safety analysis is one of the most difficult aspects of integration.

  4. Thermodynamic analyses of municipal solid waste gasification plant integrated with solid oxide fuel cell and Stirling hybrid system

    DEFF Research Database (Denmark)

    Rokni, Masoud

    2015-01-01

    is subject to chemical treatments through air or/and steam utilization; the result is a synthesis gas, called "Syngas" which is principally composed of hydrogen and carbon monoxide. Traces of hydrogen sulfide could also be present which can easily be separated in a desulfurization reactor. The gasification...... process is usually based on an atmospheric-pressure circulating fluidized bed gasifier coupled to a tar-cracking vessel. Syngas can be used as fuel in different kind of power plant such as gas turbine cycle, steam cycle, combined cycle, internal and external combustion engine and Solid Oxide Fuel Cell...... with incineration technologies. Moreover waste incinerators require the installation of sophisticated exhaust gas cleaning equipment that can be large and expensive and are not necessary in the studied plant....

  5. SOFC system with integrated catalytic fuel processing

    Energy Technology Data Exchange (ETDEWEB)

    Finnerty, C.; Tompsett, G.A.; Kendall, K.; Ormerod, R.M. [Birchall Centre for Inorganic Chemistry and Materials Science, Keele Univ. (United Kingdom)

    2000-03-01

    In recent years, there has been much interest in the development of solid oxide fuel cell technology operating directly on hydrocarbon fuels. The development of a catalytic fuel processing system, which is integrated with the solid oxide fuel cell (SOFC) power source is outlined here. The catalytic device utilises a novel three-way catalytic system consisting of an in situ pre-reformer catalyst, the fuel cell anode catalyst and a platinum-based combustion catalyst. The three individual catalytic stages have been tested in a model catalytic microreactor. Both temperature-programmed and isothermal reaction techniques have been applied. Results from these experiments were used to design the demonstration SOFC unit. The apparatus used for catalytic characterisation can also perform in situ electrochemical measurements as described in previous papers [C.M. Finnerty, R.H. Cunningham, K. Kendall, R.M. Ormerod, Chem. Commun. (1998) 915-916; C.M. Finnerty, N.J. Coe, R.H. Cunningham, R.M. Ormerod, Catal. Today 46 (1998) 137-145]. This enabled the performance of the SOFC to be determined at a range of temperatures and reaction conditions, with current output of 290 mA cm{sup -2} at 0.5 V, being recorded. Methane and butane have been evaluated as fuels. Thus, optimisation of the in situ partial oxidation pre-reforming catalyst was essential, with catalysts producing high H{sub 2}/CO ratios at reaction temperatures between 873 K and 1173 K being chosen. These included Ru and Ni/Mo-based catalysts. Hydrocarbon fuels were directly injected into the catalytic SOFC system. Microreactor measurements revealed the reaction mechanisms as the fuel was transported through the three-catalyst device. The demonstration system showed that the fuel processing could be successfully integrated with the SOFC stack. (orig.)

  6. SOFC system with integrated catalytic fuel processing

    Science.gov (United States)

    Finnerty, Caine; Tompsett, Geoff. A.; Kendall, Kevin; Ormerod, R. Mark

    In recent years, there has been much interest in the development of solid oxide fuel cell technology operating directly on hydrocarbon fuels. The development of a catalytic fuel processing system, which is integrated with the solid oxide fuel cell (SOFC) power source is outlined here. The catalytic device utilises a novel three-way catalytic system consisting of an in situ pre-reformer catalyst, the fuel cell anode catalyst and a platinum-based combustion catalyst. The three individual catalytic stages have been tested in a model catalytic microreactor. Both temperature-programmed and isothermal reaction techniques have been applied. Results from these experiments were used to design the demonstration SOFC unit. The apparatus used for catalytic characterisation can also perform in situ electrochemical measurements as described in previous papers [C.M. Finnerty, R.H. Cunningham, K. Kendall, R.M. Ormerod, Chem. Commun. (1998) 915-916; C.M. Finnerty, N.J. Coe, R.H. Cunningham, R.M. Ormerod, Catal. Today 46 (1998) 137-145]. This enabled the performance of the SOFC to be determined at a range of temperatures and reaction conditions, with current output of 290 mA cm -2 at 0.5 V, being recorded. Methane and butane have been evaluated as fuels. Thus, optimisation of the in situ partial oxidation pre-reforming catalyst was essential, with catalysts producing high H 2/CO ratios at reaction temperatures between 873 K and 1173 K being chosen. These included Ru and Ni/Mo-based catalysts. Hydrocarbon fuels were directly injected into the catalytic SOFC system. Microreactor measurements revealed the reaction mechanisms as the fuel was transported through the three-catalyst device. The demonstration system showed that the fuel processing could be successfully integrated with the SOFC stack.

  7. Developing Metrics in Systems Integration (ISS Program COTS Integration Model)

    Science.gov (United States)

    Lueders, Kathryn

    2007-01-01

    This viewgraph presentation reviews some of the complications in developing metrics for systems integration. Specifically it reviews a case study of how two programs within NASA try to develop and measure performance while meeting the encompassing organizational goals.

  8. Integrated Power, Avionics, and Software (IPAS) Flexible Systems Integration Project

    Data.gov (United States)

    National Aeronautics and Space Administration — iPAS will develop several important technologies required to support system design and integration as well as space technology maturation. These services include:A...

  9. Tracking-integrated systems for concentrating photovoltaics

    Science.gov (United States)

    Apostoleris, Harry; Stefancich, Marco; Chiesa, Matteo

    2016-04-01

    Concentrating photovoltaic (CPV) systems, which use optical elements to focus light onto small-area solar cells, have the potential to minimize the costs, while improving efficiency, of photovoltaic technology. However, CPV is limited by the need to track the apparent motion of the Sun. This is typically accomplished using high-precision mechanical trackers that rotate the entire module to maintain normal light incidence. These machines are large, heavy and expensive to build and maintain, deterring commercial interest and excluding CPV from the residential market. To avoid this issue, some attention has recently been devoted to the development of tracking-integrated systems, in which tracking is performed inside the CPV module itself. This creates a compact system geometry that could be less expensive and more suitable for rooftop installation than existing CPV trackers. We review the basic tracking principles and concepts exploited in these systems, describe and categorize the existing designs, and discuss the potential impact of tracking integration on CPV cost models and commercial potential.

  10. Integrated nanoscale tools for interrogating living cells

    Science.gov (United States)

    Jorgolli, Marsela

    The development of next-generation, nanoscale technologies that interface biological systems will pave the way towards new understanding of such complex systems. Nanowires -- one-dimensional nanoscale structures -- have shown unique potential as an ideal physical interface to biological systems. Herein, we focus on the development of nanowire-based devices that can enable a wide variety of biological studies. First, we built upon standard nanofabrication techniques to optimize nanowire devices, resulting in perfectly ordered arrays of both opaque (Silicon) and transparent (Silicon dioxide) nanowires with user defined structural profile, densities, and overall patterns, as well as high sample consistency and large scale production. The high-precision and well-controlled fabrication method in conjunction with additional technologies laid the foundation for the generation of highly specialized platforms for imaging, electrochemical interrogation, and molecular biology. Next, we utilized nanowires as the fundamental structure in the development of integrated nanoelectronic platforms to directly interrogate the electrical activity of biological systems. Initially, we generated a scalable intracellular electrode platform based on vertical nanowires that allows for parallel electrical interfacing to multiple mammalian neurons. Our prototype device consisted of 16 individually addressable stimulation/recording sites, each containing an array of 9 electrically active silicon nanowires. We showed that these vertical nanowire electrode arrays could intracellularly record and stimulate neuronal activity in dissociated cultures of rat cortical neurons similar to patch clamp electrodes. In addition, we used our intracellular electrode platform to measure multiple individual synaptic connections, which enables the reconstruction of the functional connectivity maps of neuronal circuits. In order to expand and improve the capability of this functional prototype device we designed

  11. Integrated analysis environment for high impact systems

    Energy Technology Data Exchange (ETDEWEB)

    Martinez, M. [Sandia National Labs., Albuquerque, NM (United States); Davis, J.; Scott, J.; Sztipanovits, J.; Karsai, G. [Vanderbilt Univ., Nashville, TN (United States). Measurement and Computing Systems Lab.

    1998-02-01

    Modeling and analysis of high consequence, high assurance systems requires special modeling considerations. System safety and reliability information must be captured in the models. Previously, high consequence systems were modeled using separate, disjoint models for safety, reliability, and security. The MultiGraph Architecture facilitates the implementation of a model integrated system for modeling and analysis of high assurance systems. Model integrated computing allows an integrated modeling technique to be applied to high consequence systems. Among the tools used for analyzing safety and reliability are a behavioral simulator and an automatic fault tree generation and analysis tool. Symbolic model checking techniques are used to efficiently investigate the system models. A method for converting finite state machine models to ordered binary decision diagrams allows the application of symbolic model checking routines to the integrated system models. This integrated approach to modeling and analysis of high consequence systems ensures consistency between the models and the different analysis tools.

  12. Mechatronic sensory system for computer integrated manufacturing

    CSIR Research Space (South Africa)

    Kumile, CM

    2007-05-01

    Full Text Available (CIM) systems plays an important role towards integrating such flexible systems. The requirement of fast and cheap design and redesign of manufacturing systems therefore is gaining in importance, considering not only the products and the physical...

  13. Cotangent Models for Integrable Systems

    Science.gov (United States)

    Kiesenhofer, Anna; Miranda, Eva

    2017-03-01

    We associate cotangent models to a neighbourhood of a Liouville torus in symplectic and Poisson manifolds focusing on b-Poisson/ b-symplectic manifolds. The semilocal equivalence with such models uses the corresponding action-angle theorems in these settings: the theorem of Liouville-Mineur-Arnold for symplectic manifolds and an action-angle theorem for regular Liouville tori in Poisson manifolds (Laurent- Gengoux et al., IntMath Res Notices IMRN 8: 1839-1869, 2011). Our models comprise regular Liouville tori of Poisson manifolds but also consider the Liouville tori on the singular locus of a b-Poisson manifold. For this latter class of Poisson structures we define a twisted cotangent model. The equivalence with this twisted cotangent model is given by an action-angle theorem recently proved by the authors and Scott (Math. Pures Appl. (9) 105(1):66-85, 2016). This viewpoint of cotangent models provides a new machinery to construct examples of integrable systems, which are especially valuable in the b-symplectic case where not many sources of examples are known. At the end of the paper we introduce non-degenerate singularities as lifted cotangent models on b-symplectic manifolds and discuss some generalizations of these models to general Poisson manifolds.

  14. Integrated microfluidic systems for DNA analysis.

    Science.gov (United States)

    Njoroge, Samuel K; Chen, Hui-Wen; Witek, Małgorzata A; Soper, Steven A

    2011-01-01

    microfluidic systems that are composed of two or more microdevices directed toward DNA analyses. Our discussions will primarily be focused on the integration of various processing steps with microcapillary electrophoresis (μCE) or microarrays. The advantages afforded by fully integrated microfluidic systems to enable challenging applications, such as single-copy DNA sequencing, single-cell gene expression analysis, pathogen detection, and forensic DNA analysis in formats that provide high throughput and point-of-analysis capabilities will be discussed as well.

  15. INTEGRATED HYDROGEN STORAGE SYSTEM MODEL

    Energy Technology Data Exchange (ETDEWEB)

    Hardy, B

    2007-11-16

    Hydrogen storage is recognized as a key technical hurdle that must be overcome for the realization of hydrogen powered vehicles. Metal hydrides and their doped variants have shown great promise as a storage material and significant advances have been made with this technology. In any practical storage system the rate of H2 uptake will be governed by all processes that affect the rate of mass transport through the bed and into the particles. These coupled processes include heat and mass transfer as well as chemical kinetics and equilibrium. However, with few exceptions, studies of metal hydrides have focused primarily on fundamental properties associated with hydrogen storage capacity and kinetics. A full understanding of the complex interplay of physical processes that occur during the charging and discharging of a practical storage system requires models that integrate the salient phenomena. For example, in the case of sodium alanate, the size of NaAlH4 crystals is on the order of 300nm and the size of polycrystalline particles may be approximately 10 times larger ({approx}3,000nm). For the bed volume to be as small as possible, it is necessary to densely pack the hydride particles. Even so, in packed beds composed of NaAlH{sub 4} particles alone, it has been observed that the void fraction is still approximately 50-60%. Because of the large void fraction and particle to particle thermal contact resistance, the thermal conductivity of the hydride is very low, on the order of 0.2 W/m-{sup o}C, Gross, Majzoub, Thomas and Sandrock [2002]. The chemical reaction for hydrogen loading is exothermic. Based on the data in Gross [2003], on the order of 10{sup 8}J of heat of is released for the uptake of 5 kg of H{sub 2}2 and complete conversion of NaH to NaAlH{sub 4}. Since the hydride reaction transitions from hydrogen loading to discharge at elevated temperatures, it is essential to control the temperature of the bed. However, the low thermal conductivity of the hydride

  16. Formal First Integrals of General Dynamical Systems

    Directory of Open Access Journals (Sweden)

    Jia Jiao

    2016-01-01

    Full Text Available The goal of this paper is trying to make a complete study on the integrability for general analytic nonlinear systems by first integrals. We will firstly give an exhaustive discussion on analytic planar systems. Then a class of higher dimensional systems with invariant manifolds will be considered; we will develop several criteria for existence of formal integrals and give some applications to illustrate our results at last.

  17. Laser and photonic systems design and integration

    CERN Document Server

    Nof, Shimon Y; Cheng, Gary J

    2014-01-01

    New, significant scientific discoveries in laser and photonic technologies, systems perspectives, and integrated design approaches can improve even further the impact in critical areas of challenge. Yet this knowledge is dispersed across several disciplines and research arenas. Laser and Photonic Systems: Design and Integration brings together a multidisciplinary group of experts to increase understanding of the ways in which systems perspectives may influence laser and photonic innovations and application integration.By bringing together chapters from leading scientists and technologists, ind

  18. Support Systems for Treatment Integrity

    Science.gov (United States)

    Goense, Pauline Brigitta; Boendermaker, Leonieke; van Yperen, Tom

    2016-01-01

    Objective: This systematic review evaluates the content of effective support provided to practitioners of evidence-based interventions in order to establish and maintain treatment integrity. Method: Four articles covering six outcome studies are included in this review, these studies (1) adequately operationalized treatment integrity procedures…

  19. Advanced Microgravity Compatible, Integrated Laundry System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Advanced Microgravity Compatible, Integrated Laundry (AMCIL) is a microgravity compatible liquid / liquid vapor, two-phase laundry system with water jet...

  20. Geometric Integrators for Classical Spin Systems

    NARCIS (Netherlands)

    Frank, J.E.; Huang, W.; Leimkuhler, B.J.

    1997-01-01

    Practical, structure-preserving methods for integrating classical Heisenberg spin systems are discussed. Two new integrators are derived and compared, including (1) a symmetric energy and spin-length preserving integrator based on a Red-Black splitting of the spin sites combined with a staggered tim

  1. Path Integration Applied to Structural Systems with Uncertain Properties

    DEFF Research Database (Denmark)

    Nielsen, Søren R.K.; Köylüoglu, H. Ugur

    Path integration (cell-to-cell mapping) method is applied to evaluate the joint probability density function (jpdf) of the response of the structural systems, with uncertain properties, subject to white noise excitation. A general methodology to deal with uncertainties is outlined and applied...

  2. Integrated Computer System of Management in Logistics

    Science.gov (United States)

    Chwesiuk, Krzysztof

    2011-06-01

    This paper aims at presenting a concept of an integrated computer system of management in logistics, particularly in supply and distribution chains. Consequently, the paper includes the basic idea of the concept of computer-based management in logistics and components of the system, such as CAM and CIM systems in production processes, and management systems for storage, materials flow, and for managing transport, forwarding and logistics companies. The platform which integrates computer-aided management systems is that of electronic data interchange.

  3. Integrated Systems Engineering Framework (ISEF)

    Data.gov (United States)

    Federal Laboratory Consortium — The ISEF is an integrated SE framework built to create and capture knowledge using a decision-centric method, high-quality data visualizations, intuitive navigation...

  4. Integrated design for space transportation system

    CERN Document Server

    Suresh, B N

    2015-01-01

    The book addresses the overall integrated design aspects of a space transportation system involving several disciplines like propulsion, vehicle structures, aerodynamics, flight mechanics, navigation, guidance and control systems, stage auxiliary systems, thermal systems etc. and discusses the system approach for design, trade off analysis, system life cycle considerations, important aspects in mission management, the risk assessment, etc. There are several books authored to describe the design aspects of various areas, viz., propulsion, aerodynamics, structures, control, etc., but there is no book which presents space transportation system (STS) design in an integrated manner. This book attempts to fill this gap by addressing systems approach for STS design, highlighting the integrated design aspects, interactions between various subsystems and interdependencies. The main focus is towards the complex integrated design to arrive at an optimum, robust and cost effective space transportation system. The orbit...

  5. Integrated regenerative fuel cell experimental evaluation

    Science.gov (United States)

    Martin, Ronald E.

    1990-01-01

    An experimental test program was conducted to investigate the performance characteristics of an integrated regenerative fuel cell (IRFC) concept. The IRFC consists of a separate fuel cell unit and electrolysis cell unit in the same structure, with internal storage of fuel cell product water and external storage of electrolysis cell produced hydrogen and oxygen. The fuel cell unit incorporates an enhanced Orbiter-type cell capable of improved performance at reduced weight. The electrolysis cell features a NiCo2O4 catalyst oxygen evolution eletrode with a porous Teflon cover to retard electrolyte loss. Six complete IRFC assemblies were assembled and performance tested at an operating temperature of 200 F (93.3 C) and reactant pressures up to 170 psia (117.2 n/cu cm) on IRFC No. 4. Anomalous pressure charge/discharge characteristics were encountered during performance evaluation. A reversible fuel cell incorporating a proprietary bi-functional oxygen electrode operated satisfactory at 200 F (93.3 C) at reactant pressures up to 50 psia (41.4 n/cu cm) as a regenerative fuel cell for one cycle, before developing an electrical short in the fuel cell mode. Electrolysis cell 300-hour endurance tests demonstrated the electrolyte retention capability of the electrode Teflon cover and the performance stability of the bi-functional oxygen electrode at high potential.

  6. Integration of Agent System with Legacy Software

    Institute of Scientific and Technical Information of China (English)

    SHEN Qi; ZHAO Yan-hong; YIN Zhao-lin

    2003-01-01

    Agent technique is a new method that can analyze, design and realize a distributed open system. It has been used in almost every field. But if act for the real practical words in technique, it must integrate with legacy software, such as database system etc, and control them. This paper introduces the specification of agent software integration, ontology, instances database as implementing agent software integration with CORBA technique and takes XML, ACL as language communicating among agents.

  7. INTEGRATIVE AUGMENTATION OF STANDARDIZED MANAGEMENT SYSTEMS

    Directory of Open Access Journals (Sweden)

    Stanislav Karapetrovic

    2008-03-01

    Full Text Available The development, features and integrating abilities of different international standards related to management systems are discussed. A group of such standards that augment the performance of quality management systems in organizations is specifically focused on. The concept, characteristics and an illustrative example of one augmenting standard, namely ISO 10001, are addressed. Integration of standardized augmenting systems, both by themselves and within the overall management system, is examined. It is argued that, in research and practice alike, integrative augmentation represents the future of standardized quality and other management systems.

  8. Integrable Hamiltonian systems and spectral theory

    CERN Document Server

    Moser, J

    1981-01-01

    Classical integrable Hamiltonian systems and isospectral deformations ; geodesics on an ellipsoid and the mechanical system of C. Neumann ; the Schrödinger equation for almost periodic potentials ; finite band potentials ; limit cases, Bargmann potentials.

  9. Advanced Microgravity Compatible, Integrated Laundry System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — An Advanced Microgravity Compatible, Integrated laundry System (AMCILS) is proposed that uses a two phase water / water vapor system to allow good agitation of...

  10. Mars Integrated Propellant Production System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Integrated Mars In-Situ Propellant Production System (IMISPPS) is an end-to-end system that will produce rocket propellant on Mars from CO2 in the Martian...

  11. Mars Integrated Propellant Production System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Integrated Mars In-Situ Propellant Production System (IMISPPS) is an end-to-end system that will produce rocket propellant on Mars from CO2 in the Martian...

  12. Integration of Mobil Satellite and Cellular Systems

    Science.gov (United States)

    Drucker, E. H.; Estabrook, P.; Pinck, D.; Ekroot, L.

    1993-01-01

    By integrating the ground based infrastructure component of a mobile satellite system with the infrastructure systems of terrestrial 800 MHz cellular service providers, a seamless network of universal coverage can be established.

  13. ON FIRST INTEGRALS OF POLYNOMIAL AUTONOMOUS SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    WANG Yuzhen; CHENG Daizhan; LI Chunwen

    2002-01-01

    Using Carleman linearization procedure, this paper investigates the problemof first integrals of polynomial autonomous systems and proposes a procedure to find thefirst integrals of polynomial family for the systems. A generalized eigenequation is obtainedand then the problem is reduced to the solvability of the eigenequation. The result is ageneralization of some known results.

  14. Vector Product and an Integrable Dynamical System

    Institute of Scientific and Technical Information of China (English)

    Willi-Hans Steeb; Yorick Hardy; Igor Tanski

    2011-01-01

    We study an autonomous system of first order ordinary differential equations based on the vector product. We show that the system is completely integrable by constructing the first integrals. The connection with Nambu mechanics is established. The extension to higher dimensions is also discussed.

  15. An Integrated Library System: Preliminary Considerations.

    Science.gov (United States)

    Neroda, Edward

    Noting difficulties experienced by small to medium sized colleges in acquiring integrated library computer systems, this position paper outlines issues related to the subject with the intention of increasing familiarity and interest in integrated library systems. The report includes: a brief review of technological advances as they relate to…

  16. Integrated Quality Information System of CIMS

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The computer integrated manufacturing system (CIMS), which is called the 21st century's production mode, is the inevitable course of manufacturing industry development. The integrated quality information system (IQIS), which is the essential component of CIMS, will be the powerful assurance to carry out a CIMS project. In this paper, the concept and the system structure and function of IQIS are discussed. The relationship between IQIS and other component systems of CIMS is analyzed.

  17. Support Systems for Treatment Integrity

    NARCIS (Netherlands)

    Goense, Pauline Brigitta; Boendermaker, Leonieke; van Yperen, Tom

    Objective: This systematic review evaluates the content of effective support provided to practitioners of evidence-based interventions in order to establish and maintain treatment integrity. Method: Four articles covering six outcome studies are included in this review, these studies (1) adequately

  18. Challenges in Business System Integration

    NARCIS (Netherlands)

    Hvolby, H.H.; Trienekens, J.H.

    2010-01-01

    Four main frameworks for intercompany relationships (SCOR, CPFR, ISA95 and OAG) are discussed and compared. The link between the frameworks and different supply chain integration applications such as ERP, CRM and VMI are pictured. Finally the state-of-the-art, future state and challenges of the

  19. Challenges in Business System Integration

    NARCIS (Netherlands)

    Hvolby, H.H.; Trienekens, J.H.

    2010-01-01

    Four main frameworks for intercompany relationships (SCOR, CPFR, ISA95 and OAG) are discussed and compared. The link between the frameworks and different supply chain integration applications such as ERP, CRM and VMI are pictured. Finally the state-of-the-art, future state and challenges of the supp

  20. Support Systems for Treatment Integrity

    NARCIS (Netherlands)

    Goense, Pauline Brigitta; Boendermaker, Leonieke; van Yperen, Tom

    2016-01-01

    Objective: This systematic review evaluates the content of effective support provided to practitioners of evidence-based interventions in order to establish and maintain treatment integrity. Method: Four articles covering six outcome studies are included in this review, these studies (1) adequately

  1. Support Systems for Treatment Integrity

    NARCIS (Netherlands)

    Goense, Pauline Brigitta; Boendermaker, Leonieke; van Yperen, Tom

    2016-01-01

    Objective: This systematic review evaluates the content of effective support provided to practitioners of evidence-based interventions in order to establish and maintain treatment integrity. Method: Four articles covering six outcome studies are included in this review, these studies (1) adequately

  2. IEA ECBCS Annex 42 'FC+GOGEN-SIM'. The simulation of building-integrated fuel cell and other cogeneration systems - Summary; IEA ECBCS Annex 42 'FC+GOGEN-SIM'. The simulation of building-integrated fuel cell and other cogeneration systems - Summary

    Energy Technology Data Exchange (ETDEWEB)

    Dorer, V.

    2008-07-01

    This summary report for the Swiss Federal Office of Energy (SFOE) takes a look at the results of three sub-tasks performed within the framework of an IEA task-annex. The sub-tasks aimed to develop simulation models for fuel-cell appliances and other micro-CHP units and to integrate them into various building simulation programs. The first sub-task covered the compilation of a technology overview as well as household power and hot-water requirements. The second one was devoted to the development of models for micro-CHP units. A third sub-task covered the simulation of various system configurations and evaluated general methods for dealing with energy, emissions and costs. The work done is briefly reviewed and the various institutions involved in the work are noted.

  3. SUBSURFACE REPOSITORY INTEGRATED CONTROL SYSTEM DESIGN

    Energy Technology Data Exchange (ETDEWEB)

    C.J. Fernado

    1998-09-17

    The purpose of this document is to develop preliminary high-level functional and physical control system architectures for the proposed subsurface repository at Yucca Mountain. This document outlines overall control system concepts that encompass and integrate the many diverse systems being considered for use within the subsurface repository. This document presents integrated design concepts for monitoring and controlling the diverse set of subsurface operations. The subsurface repository design will be composed of a series of diverse systems that will be integrated to accomplish a set of overall functions and objectives. The subsurface repository contains several Instrumentation and Control (I&C) related systems including: waste emplacement systems, ventilation systems, communication systems, radiation monitoring systems, rail transportation systems, ground control monitoring systems, utility monitoring systems (electrical, lighting, water, compressed air, etc.), fire detection and protection systems, retrieval systems, and performance confirmation systems. Each of these systems involve some level of I&C and will typically be integrated over a data communication network. The subsurface I&C systems will also integrate with multiple surface-based site-wide systems such as emergency response, health physics, security and safeguards, communications, utilities and others. The scope and primary objectives of this analysis are to: (1) Identify preliminary system level functions and interface needs (Presented in the functional diagrams in Section 7.2). (2) Examine the overall system complexity and determine how and on what levels these control systems will be controlled and integrated (Presented in Section 7.2). (3) Develop a preliminary subsurface facility-wide design for an overall control system architecture, and depict this design by a series of control system functional block diagrams (Presented in Section 7.2). (4) Develop a series of physical architectures that

  4. Guest editorial. Integrated healthcare information systems.

    Science.gov (United States)

    Li, Ling; Ge, Ri-Li; Zhou, Shang-Ming; Valerdi, Ricardo

    2012-07-01

    The use of integrated information systems for healthcare has been started more than a decade ago. In recent years, rapid advances in information integration methods have spurred tremendous growth in the use of integrated information systems in healthcare delivery. Various techniques have been used for probing such integrated systems. These techniques include service-oriented architecture (SOA), EAI, workflow management, grid computing, and others. Many applications require a combination of these techniques, which gives rise to the emergence of enterprise systems in healthcare. Development of the techniques originated from different disciplines has the potential to significantly improve the performance of enterprise systems in healthcare. This editorial paper briefly introduces the enterprise systems in the perspective of healthcare informatics.

  5. Integrated design of legged mechatronic system

    Institute of Scientific and Technical Information of China (English)

    ChinYin CHEN; IMing CHEN; ChiCheng CHENG

    2009-01-01

    This paper presents a system based on the integrated design and experiment for a one degree-of-freedom (DOF) legged mechatronic system (LMTS). A six-bar linkage mechanism, which is derived from a four-bar linkage with a symmetrical coupler point and pantograph into one, is designed, and common controllers are used to control the velocity and position loops.For system-based dynamic optimization, the design for control (DFC) approach is used to integrate the structure and control for improving dynamic performance with reduced control torque.Finally, for a rapid 3D graphical based implementation of the system, high-level computer-aided rapid system integration (CARSI) technology is used to integrate the structure design, controller design, and system implemen-tation into the design and analytical software environment based on Pro/engineer, XML syntax, Simmechanics, and Simulink. Thus, the development time for the LMTS is reduced.

  6. Health systems integration: state of the evidence

    Directory of Open Access Journals (Sweden)

    Gail D. Armitage

    2009-06-01

    Full Text Available Introduction: Integrated health systems are considered a solution to the challenge of maintaining the accessibility and integrity of healthcare in numerous jurisdictions worldwide. However, decision makers in a Canadian health region indicated they were challenged to find evidence-based information to assist with the planning and implementation of integrated healthcare systems. Methods: A systematic literature review of peer-reviewed literature from health sciences and business databases, and targeted grey literature sources. Results: Despite the large number of articles discussing integration, significant gaps in the research literature exist. There was a lack of high quality, empirical studies providing evidence on how health systems can improve service delivery and population health. No universal definition or concept of integration was found and multiple integration models from both the healthcare and business literature were proposed in the literature. The review also revealed a lack of standardized, validated tools that have been systematically used to evaluate integration outcomes. This makes measuring and comparing the impact of integration on system, provider and patient level challenging. Discussion and conclusion: Healthcare is likely too complex for a one-size-fits-all integration solution. It is important for decision makers and planners to choose a set of complementary models, structures and processes to create an integrated health system that fits the needs of the population across the continuum of care. However, in order to have evidence available, decision makers and planners should include evaluation for accountability purposes and to ensure a better understanding of the effectiveness and impact of health systems integration.

  7. Mobility Integration of ERP systems

    Directory of Open Access Journals (Sweden)

    Álvaro LOZANO

    2015-03-01

    Full Text Available Nowadays a lot of enterprises work with ERP systems. It usefulness is generally used in office environments and different enterprises which offer this software are developing mobile applications. These mobile applications work with their own system and they don’t usually work in other platforms. Currently any mobile application can communicate with more than one ERP system because each one has its own communications methods. This article presents a system that expect unify the communication between different ERP systems and allows mobile applications to communicate with them in a homogeneous way.

  8. Integration of mobile satellite and cellular systems

    Science.gov (United States)

    Drucker, Elliott H.; Estabrook, Polly; Pinck, Deborah; Ekroot, Laura

    1993-01-01

    By integrating the ground based infrastructure component of a mobile satellite system with the infrastructure systems of terrestrial 800 MHz cellular service providers, a seamless network of universal coverage can be established. Users equipped for both cellular and satellite service can take advantage of a number of features made possible by such integration, including seamless handoff and universal roaming. To provide maximum benefit at lowest posible cost, the means by which these systems are integrated must be carefully considered. Mobile satellite hub stations must be configured to efficiently interface with cellular Mobile Telephone Switching Offices (MTSO's), and cost effective mobile units that provide both cellular and satellite capability must be developed.

  9. Integrated optical devices for photonics instrumentation systems

    Energy Technology Data Exchange (ETDEWEB)

    McWright, G.M.; Lafaw, D.A.; Lowry, M.; Tindall, W.

    1990-01-01

    We discuss the design, fabrication, and evaluation of high speed integrated optical devices for application to photonics instrumentation systems. Specifically, we have demonstrated integrated optical devices with bandwidths in excess of 25 GHz and implemented these devices in single-shot, streak camera based recording schemes. 5 refs., 6 figs.

  10. Smart Systems Integration for Autonomous Wireless Communications

    NARCIS (Netherlands)

    Danesh, M.

    2012-01-01

    Integration of sensors and wireless transceivers for system networking aims at emerging applications that are highly integrated, self-powered, and low cost, relying on efficient power management schemes to prolong lifetime, thus eliminating the need for batteries as a limited primary source of energ

  11. Smart Systems Integration for Autonomous Wireless Communications

    NARCIS (Netherlands)

    Danesh, M.

    2012-01-01

    Integration of sensors and wireless transceivers for system networking aims at emerging applications that are highly integrated, self-powered, and low cost, relying on efficient power management schemes to prolong lifetime, thus eliminating the need for batteries as a limited primary source of

  12. Smart Systems Integration for Autonomous Wireless Communications

    NARCIS (Netherlands)

    Danesh, M.

    2012-01-01

    Integration of sensors and wireless transceivers for system networking aims at emerging applications that are highly integrated, self-powered, and low cost, relying on efficient power management schemes to prolong lifetime, thus eliminating the need for batteries as a limited primary source of energ

  13. Partial Automated Alignment and Integration System

    Science.gov (United States)

    Kelley, Gary Wayne (Inventor)

    2014-01-01

    The present invention is a Partial Automated Alignment and Integration System (PAAIS) used to automate the alignment and integration of space vehicle components. A PAAIS includes ground support apparatuses, a track assembly with a plurality of energy-emitting components and an energy-receiving component containing a plurality of energy-receiving surfaces. Communication components and processors allow communication and feedback through PAAIS.

  14. Integrated Monitoring System of Production Processes

    Directory of Open Access Journals (Sweden)

    Oborski Przemysław

    2016-12-01

    Full Text Available Integrated monitoring system for discrete manufacturing processes is presented in the paper. The multilayer hardware and software reference model was developed. Original research are an answer for industry needs of the integration of information flow in production process. Reference model corresponds with proposed data model based on multilayer data tree allowing to describe orders, products, processes and save monitoring data. Elaborated models were implemented in the integrated monitoring system demonstrator developed in the project. It was built on the base of multiagent technology to assure high flexibility and openness on applying intelligent algorithms for data processing. Currently on the base of achieved experience an application integrated monitoring system for real production system is developed. In the article the main problems of monitoring integration are presented, including specificity of discrete production, data processing and future application of Cyber-Physical-Systems. Development of manufacturing systems is based more and more on taking an advantage of applying intelligent solutions into machine and production process control and monitoring. Connection of technical systems, machine tools and manufacturing processes monitoring with advanced information processing seems to be one of the most important areas of near future development. It will play important role in efficient operation and competitiveness of the whole production system. It is also important area of applying in the future Cyber-Physical-Systems that can radically improve functionally of monitoring systems and reduce the cost of its implementation.

  15. Human-Systems Integration Processes (HSIP) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In FY12, this project removed the commercial-specific content from the Commercial Human-Systems Integration Design Processes (CHSIP), identified gaps in the...

  16. Higher Spin Lifshitz Theory and Integrable Systems

    CERN Document Server

    Gutperle, Michael

    2014-01-01

    In this note we construct asymptotically Lifshitz spacetimes in the Chern-Simons formulation of three dimensional higher spin gravity and relate the resulting theories to integrable systems which are elements of the KdV hierarchy.

  17. Energy Systems Integration: NREL + Solectria (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2015-02-01

    This fact sheet describes the collaboration between NREL and Solectria at the Energy Systems Integration Facility (ESIF) to to develop 500- and 750-kilowatt photovoltaic (PV) inverters with advanced features that can support the electric grid.

  18. Integrative System of Fast Photoacoustic Imaging

    Science.gov (United States)

    Yi, Tan

    An integrative fast (Photoacoustic) PA imaging system based on multi-element linear ultrasonic transducer array was developed, which integrates laser delivery, photoacoustic excitation and photoacoustic detection into a portable system. It collects PA signals by a multi-element linear transducer array in a reflection mode. The PA images with high spatial resolution and high contrast were obtained. Compared to other existing PA imaging methods, the integrative PA imaging system is characterized by rapidness, convenience and high practicality. The integrative system is mobile and portable, and it is suitable for imaging samples in natural condition with various different shapes. It will provide a novel and effective PA imaging approach for clinic diagnosis of neoplasm and tissue functional imaging in vivo, and has potential to be developed into a practical apparatus used in the early non-invasive detection of breast-cancer.

  19. Development of system integration technology for integral reactor

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Moon Hee; Kang, D. J.; Kim, K. K. and others

    1999-03-01

    The objective of this report is to integrate the conceptual design of an integral reactor, SMART producing thermal energy of 330 MW, which will be utilized to supply energy for seawater desalination and small-scale power generation. This project also aims to develop system integration technology for effective design of the reactor. For the conceptual design of SMART, preliminary design requirements including the top-tier requirements and design bases were evaluated and established. Furthermore, in the view of the application of codes and standards to the SMART design, existing laws, codes and standards were analyzed and evaluated with respect to its applicability. As a part of this evaluation, directions and guidelines were proposed for the development of new codes and standards which shall be applied to the SMART design. Regarding the integration of SMART conceptual designs, major design activities and interfaces between design departments were established and coordinated through the design process. For the effective management of all design schedules, a work performance evaluation system was developed and applied to the design process. As the results of this activity, an integrated output of SMART designs was produced. Two additional scopes performed in this project include the preliminary economic analysis on the SMART utilization for seawater desalination, and the planning of verification tests for technology implemented into SMART and establishing development plan of the computer codes to be used for SMART design in the next phase. The technical cooperation with foreign country and international organization for securing technologies for integral reactor design and its application was coordinated and managed through this project. (author)

  20. SUBSURFACE REPOSITORY INTEGRATED CONTROL SYSTEM DESIGN

    Energy Technology Data Exchange (ETDEWEB)

    D.C. Randle

    2000-01-07

    The primary purpose of this document is to develop a preliminary high-level functional and physical control system architecture for the potential repository at Yucca Mountain. This document outlines an overall control system concept that encompasses and integrates the many diverse process and communication systems being developed for the subsurface repository design. This document presents integrated design concepts for monitoring and controlling the diverse set of subsurface operations. The Subsurface Repository Integrated Control System design will be composed of a series of diverse process systems and communication networks. The subsurface repository design contains many systems related to instrumentation and control (I&C) for both repository development and waste emplacement operations. These systems include waste emplacement, waste retrieval, ventilation, radiological and air monitoring, rail transportation, construction development, utility systems (electrical, lighting, water, compressed air, etc.), fire protection, backfill emplacement, and performance confirmation. Each of these systems involves some level of I&C and will typically be integrated over a data communications network throughout the subsurface facility. The subsurface I&C systems will also interface with multiple surface-based systems such as site operations, rail transportation, security and safeguards, and electrical/piped utilities. In addition to the I&C systems, the subsurface repository design also contains systems related to voice and video communications. The components for each of these systems will be distributed and linked over voice and video communication networks throughout the subsurface facility. The scope and primary objectives of this design analysis are to: (1) Identify preliminary system-level functions and interfaces (Section 6.2). (2) Examine the overall system complexity and determine how and on what levels the engineered process systems will be monitored, controlled, and

  1. Integrable systems in stringy gravity

    CERN Document Server

    Galtsov, D V

    1995-01-01

    Static axisymmetric Einstein-Maxwell-Dilaton and stationary axisymmetric Einstein-Maxwell-Dilaton-Axion (EMDA) theories in four space-time dimensions are shown to be integrable by means of the inverse scattering transform method. The proof is based on the coset-space representation of the 4-dim theory in a space-time admitting a Killing vector field. Hidden symmetry group of the four-dimensional EMDA theory, unifying T and S string dualities, is shown to be Sp(2, R) acting transitively on the coset Sp(2, R)/U(2). In the case of two-parameter Abelian space-time isometry group, the hidden symmetry is the corresponding infinite-dimensional group of the Geroch-Kinnersley-Chitre type.

  2. How to Evaluate Integrated Library Automation Systems.

    Science.gov (United States)

    Powell, James R.; Slach, June E.

    1985-01-01

    This paper describes methodology used in compiling a list of candidate integrated library automation systems at a corporate technical library. Priorities for automation, identification of candidate systems, the filtering process, information for suppliers, software and hardware considerations, on-site evaluations, and final system selection are…

  3. The Integrated Library System: A Historical Overview.

    Science.gov (United States)

    Dick, Richard S.

    1984-01-01

    Discusses evolution of Integrated Library System (ILS) since its beginning at National Library of Medicine, highlighting events leading to ILS development; formative design stages, formation of Online Computer System; installation of ILS version 1.0 at Pentagon library; development of version 2.0, formation of Avatar Systems; OCLC's acquisition of…

  4. Level statistics for nearly integrable systems.

    Science.gov (United States)

    Abul-Magd, A Y

    2009-07-01

    We assume that the level spectra of quantum systems in the initial phase of transition from integrability to chaos are approximated by superpositions of independent sequences. Each individual sequence is modeled by a random matrix ensemble. We obtain analytical expressions for the level spacing distribution and level number variance for such a system. These expressions are successfully applied to the analysis of the resonance spectrum in a nearly integrable microwave billiard.

  5. Human Systems Integration (HSI) in Acquisition

    Science.gov (United States)

    2009-08-01

    Cost/Risk Drivers The numbers in the Activities boxes correspond to the numbers In the Inputs and Outputs boxes. Tools: ● CATIA ● HSI Requirements...Technology Development Phase (Inputs) Human Systems Integration Tools: ● IMPRINT ● CATIA ● IPME References: ● DODI 5000.02 & DODD 5000.01 ● DAG ● CJCSI...Human Systems Integration Tools: ● IMPRINT ● CATIA ● IPME Activities for Each Output: 1.0 Incorporate domain considerations into baseline

  6. Optimised Hybrid Integrated Renewable Energy System

    Directory of Open Access Journals (Sweden)

    Dr. Arun Sandilya

    2012-10-01

    Full Text Available A hybrid integrated renewable energy system for an isolated small community, where grid extension is considered uneconomical. This paper proposed cost optimization through dynamic matching between load and proper equipment sizing. The Matlab based computer program developed for determining the most cost effective energy source to supply required load any given time of the day. Integrated system based on green energy utilization and rural electricity development.

  7. Exact quantization conditions for cluster integrable systems

    Science.gov (United States)

    Franco, Sebastián; Hatsuda, Yasuyuki; Mariño, Marcos

    2016-06-01

    We propose exact quantization conditions for the quantum integrable systems of Goncharov and Kenyon, based on the enumerative geometry of the corresponding toric Calabi-Yau manifolds. Our conjecture builds upon recent results on the quantization of mirror curves, and generalizes a previous proposal for the quantization of the relativistic Toda lattice. We present explicit tests of our conjecture for the integrable systems associated to the resolved {{{C}}3}/{{{Z}}5} and {{{C}}3}/{{{Z}}6} orbifolds.

  8. Exact quantization conditions for cluster integrable systems

    CERN Document Server

    Franco, Sebastian; Marino, Marcos

    2015-01-01

    We propose exact quantization conditions for the quantum integrable systems of Goncharov and Kenyon, based on the enumerative geometry of the corresponding toric Calabi-Yau manifolds. Our conjecture builds upon recent results on the quantization of mirror curves, and generalizes a previous proposal for the quantization of the relativistic Toda lattice. We present explicit tests of our conjecture for the integrable systems associated to the resolved C^3/Z_5 and C^3/Z_6 orbifolds.

  9. Integrability of dynamical systems algebra and analysis

    CERN Document Server

    Zhang, Xiang

    2017-01-01

    This is the first book to systematically state the fundamental theory of integrability and its development of ordinary differential equations with emphasis on the Darboux theory of integrability and local integrability together with their applications. It summarizes the classical results of Darboux integrability and its modern development together with their related Darboux polynomials and their applications in the reduction of Liouville and elementary integrabilty and in the center—focus problem, the weakened Hilbert 16th problem on algebraic limit cycles and the global dynamical analysis of some realistic models in fields such as physics, mechanics and biology. Although it can be used as a textbook for graduate students in dynamical systems, it is intended as supplementary reading for graduate students from mathematics, physics, mechanics and engineering in courses related to the qualitative theory, bifurcation theory and the theory of integrability of dynamical systems.

  10. Formalisms for reuse and systems integration

    CERN Document Server

    Rubin, Stuart

    2015-01-01

    Reuse and integration are defined as synergistic concepts, where reuse addresses how to minimize redundancy in the creation of components; while, integration focuses on component composition. Integration supports reuse and vice versa. These related concepts support the design of software and systems for maximizing performance while minimizing cost. Knowledge, like data, is subject to reuse; and, each can be interpreted as the other. This means that inherent complexity, a measure of the potential utility of a system, is directly proportional to the extent to which it maximizes reuse and integration. Formal methods can provide an appropriate context for the rigorous handling of these synergistic concepts. Furthermore, formal languages allow for non ambiguous model specification; and, formal verification techniques provide support for insuring the validity of reuse and integration mechanisms.   This edited book includes 12 high quality research papers written by experts in formal aspects of reuse and integratio...

  11. Quality Management and Integrated Management System

    OpenAIRE

    2011-01-01

    Graduation theses is directed on the Management System and the characteristics of the company and its development since 2003. Theses is introduced on the Integrated Management System, which consists of the Quality Management System, the Environmental Management System and the Occupational Health and Safety Assessment Series. The theses is especially directed on the Occupational Health and Safety Assessment Series. Management System is analyzed and steps are recommended to improve these proces...

  12. Supersymmetry and integrability in planar mechanical systems

    Energy Technology Data Exchange (ETDEWEB)

    Assis, Leonardo P.G. de; Helayel-Neto, Jose A. [Grupo de Fisica Teorica Jose Leite Lopes, Petropolis, RJ (Brazil)]. E-mail: lpgassis@cbpf.br; helayel@cbpf.br; Paschoal, Ricardo C. [Centro de Tecnologia da Industria Quimica e/ Textil (SENAI/CETIQT), Rio de Janeiro, RJ (Brazil)]. E-mail: paschoal@cbpf.br

    2005-05-15

    We present an N = 2-supersymmetric mechanical system whose bosonic sector, with two degrees of freedom, stems from the reduction of an SU(2) Yang-Mills theory with the assumption of spatially homogeneous field configurations and a particular Ansatz imposed on the gauge potentials in the dimensional reduction procedure. The Painleve test is adopted to discuss integrability and we focus on the role of supersymmetry and parity invariance in two space dimensions for the attainment of integrable or chaotic models. Our conclusion is that the relationships among the parameters imposed by supersymmetry seem to drastically reduce the number of possibilities for integrable interaction potentials of the mechanical system under consideration. (author)

  13. Integrability of Lie Systems Through Riccati Equations

    Science.gov (United States)

    Cariñena, José F.; de Lucas, Javier

    Integrability conditions for Lie systems are related to reduction or transformation processes. We here analyse a geometric method to construct integrability conditions for Riccati equations following these approaches. This approach provides us with a unified geometrical viewpoint that allows us to analyse some previous works on the topic and explain new properties. Moreover, this new approach can be straightforwardly generalised to describe integrability conditions for any Lie system. Finally, we show the usefulness of our treatment in order to study the problem of the linearisability of Riccati equations.

  14. Integrability of Lie systems through Riccati equations

    CERN Document Server

    Cariñena, José F

    2010-01-01

    Integrability conditions for Lie systems are related to reduction or transformation processes. We here analyse a geometric method to construct integrability conditions for Riccati equations following these approaches. This approach provides us with a unified geometrical viewpoint that allows us to analyse some previous works on the topic and explain new properties. Moreover, this new approach can be straightforwardly generalised to describe integrability conditions for any Lie system. Finally, we show the usefulness of our treatment in order to study the problem of the linearisability of Riccati equations.

  15. The Integral Burst Alert System (IBAS)

    CERN Document Server

    Mereghetti, S; Borkowski, J J; Walter, R; Pedersen, H

    2003-01-01

    We describe the INTEGRAL Burst Alert System (IBAS): the automatic software for the rapid distribution of the coordinates of the Gamma-Ray Bursts detected by INTEGRAL. IBAS is implemented as a ground based system, working on the near-real time telemetry stream. During the first six months of operations, six GRB have been detected in the field of view of the INTEGRAL instruments and localized by IBAS. Positions with an accuracy of a few arcminutes are currently distributed by IBAS to the community for follow-up observations within a few tens of seconds of the event.

  16. Advanced optical manufacturing digital integrated system

    Science.gov (United States)

    Tao, Yizheng; Li, Xinglan; Li, Wei; Tang, Dingyong

    2012-10-01

    It is necessarily to adapt development of advanced optical manufacturing technology with modern science technology development. To solved these problems which low of ration, ratio of finished product, repetition, consistent in big size and high precision in advanced optical component manufacturing. Applied business driven and method of Rational Unified Process, this paper has researched advanced optical manufacturing process flow, requirement of Advanced Optical Manufacturing integrated System, and put forward architecture and key technology of it. Designed Optical component core and Manufacturing process driven of Advanced Optical Manufacturing Digital Integrated System. the result displayed effective well, realized dynamic planning Manufacturing process, information integration improved ratio of production manufactory.

  17. Cell mechanics: integrating cell responses to mechanical stimuli.

    Science.gov (United States)

    Janmey, Paul A; McCulloch, Christopher A

    2007-01-01

    Forces are increasingly recognized as major regulators of cell structure and function, and the mechanical properties of cells are essential to the mechanisms by which cells sense forces, transmit them to the cell interior or to other cells, and transduce them into chemical signals that impact a spectrum of cellular responses. Comparison of the mechanical properties of intact cells with those of the purified cytoskeletal biopolymers that are thought to dominate their elasticity reveal the extent to which the studies of purified systems can account for the mechanical properties of the much more heterogeneous and complex cell. This review summarizes selected aspects of current work on cell mechanics with an emphasis on the structures that are activated in cell-cell contacts, that regulate ion flow across the plasma membrane, and that may sense fluid flow that produces low levels of shear stress.

  18. Systems cell biology.

    Science.gov (United States)

    Mast, Fred D; Ratushny, Alexander V; Aitchison, John D

    2014-09-15

    Systems cell biology melds high-throughput experimentation with quantitative analysis and modeling to understand many critical processes that contribute to cellular organization and dynamics. Recently, there have been several advances in technology and in the application of modeling approaches that enable the exploration of the dynamic properties of cells. Merging technology and computation offers an opportunity to objectively address unsolved cellular mechanisms, and has revealed emergent properties and helped to gain a more comprehensive and fundamental understanding of cell biology.

  19. Modular PEM Fuel Cell SCADA & Simulator System

    Directory of Open Access Journals (Sweden)

    Francisca Segura

    2015-09-01

    Full Text Available The paper presents a Supervision, Control, Data Acquisition and Simulation (SCADA & Simulator system that allows for real-time training in the actual operation of a modular PEM fuel cell system. This SCADA & Simulator system consists of a free software tool that operates in real time and simulates real situations like failures and breakdowns in the system. This developed SCADA & Simulator system allows us to properly operate a fuel cell and helps us to understand how fuel cells operate and what devices are needed to configure and run the fuel cells, from the individual stack up to the whole fuel cell system. The SCADA & Simulator system governs a modular system integrated by three PEM fuel cells achieving power rates higher than tens of kilowatts.

  20. First integral method for an oscillator system

    Directory of Open Access Journals (Sweden)

    Xiaoqian Gong

    2013-04-01

    Full Text Available In this article, we consider the nonlinear Duffing-van der Pol-type oscillator system by means of the first integral method. This system has physical relevance as a model in certain flow-induced structural vibration problems, which includes the van der Pol oscillator and the damped Duffing oscillator etc as particular cases. Firstly, we apply the Division Theorem for two variables in the complex domain, which is based on the ring theory of commutative algebra, to explore a quasi-polynomial first integral to an equivalent autonomous system. Then, through solving an algebraic system we derive the first integral of the Duffing-van der Pol-type oscillator system under certain parametric condition.

  1. Integrated Project Management System description. [UMTRAP Project

    Energy Technology Data Exchange (ETDEWEB)

    1987-03-01

    The Uranium Mill Tailings Remedial Action (UMTRA) Project is a Department of Energy (DOE) designated Major System Acquisition (MSA). To execute and manage the Project mission successfully and to comply with the MSA requirements, the UMTRA Project Office ( Project Office'') has implemented and operates an Integrated Project Management System (IPMS). The Project Office is assisted by the Technical Assistance Contractor's (TAC) Project Integration and Control (PIC) Group in system operation. Each participant, in turn, provides critical input to system operation and reporting requirements. The IPMS provides a uniform structured approach for integrating the work of Project participants. It serves as a tool for planning and control, workload management, performance measurement, and specialized reporting within a standardized format. This system description presents the guidance for its operation. Appendices 1 and 2 contain definitions of commonly used terms and abbreviations and acronyms, respectively. 17 figs., 5 tabs.

  2. Aircraft System Design and Integration

    Directory of Open Access Journals (Sweden)

    D. P. Coldbeck

    2000-01-01

    Full Text Available In the 1980's the British aircraft industry changed its approach to the management of projects from a system where a project office would manage a project and rely on a series of specialist departments to support them to a more process oriented method, using systems engineering models, whose most outwardly visible signs were the introduction of multidisciplinary product teams. One of the problems with the old method was that the individual departments often had different priorities and projects would get uneven support. The change in the system was only made possible for complex designs by the electronic distribution of data giving instantaneous access to all involved in the project. In 1997 the Defence and Aerospace Foresight Panel emphasised the need for a system engineering approach if British industry was to remain competitive. The Royal Academy of Engineering recognised that the change in working practices also changed what was required of a chartered engineer and redefined their requirements in 1997 [1]. The result of this is that engineering degree courses are now judged against new criteria with more emphasis placed on the relevance to industry rather than on purely academic content. At the University of Glasgow it was realized that the students ought to be made aware of current working practices and that there ought to be a review to ensure that the degrees give students the skills required by industry. It was decided to produce a one week introduction course in systems engineering for Masters of Engineering (MEng students to be taught by both university lecturers and practitioners from a range of companies in the aerospace industry with the hope of expanding the course into a module. The reaction of the students was favourable in terms of the content but it seems ironic that the main criticism was that there was not enough discussion involving the students. This paper briefly describes the individual teaching modules and discusses the

  3. Distributed Access View Integrated Database (DAVID) system

    Science.gov (United States)

    Jacobs, Barry E.

    1991-01-01

    The Distributed Access View Integrated Database (DAVID) System, which was adopted by the Astrophysics Division for their Astrophysics Data System, is a solution to the system heterogeneity problem. The heterogeneous components of the Astrophysics problem is outlined. The Library and Library Consortium levels of the DAVID approach are described. The 'books' and 'kits' level is discussed. The Universal Object Typer Management System level is described. The relation of the DAVID project with the Small Business Innovative Research (SBIR) program is explained.

  4. Integrating human stem cell expansion and neuronal differentiation in bioreactors

    Directory of Open Access Journals (Sweden)

    Costa Eunice M

    2009-09-01

    Full Text Available Abstract Background Human stem cells are cellular resources with outstanding potential for cell therapy. However, for the fulfillment of this application, major challenges remain to be met. Of paramount importance is the development of robust systems for in vitro stem cell expansion and differentiation. In this work, we successfully developed an efficient scalable bioprocess for the fast production of human neurons. Results The expansion of undifferentiated human embryonal carcinoma stem cells (NTera2/cl.D1 cell line as 3D-aggregates was firstly optimized in spinner vessel. The media exchange operation mode with an inoculum concentration of 4 × 105 cell/mL was the most efficient strategy tested, with a 4.6-fold increase in cell concentration achieved in 5 days. These results were validated in a bioreactor where similar profile and metabolic performance were obtained. Furthermore, characterization of the expanded population by immunofluorescence microscopy and flow cytometry showed that NT2 cells maintained their stem cell characteristics along the bioreactor culture time. Finally, the neuronal differentiation step was integrated in the bioreactor process, by addition of retinoic acid when cells were in the middle of the exponential phase. Neurosphere composition was monitored and neuronal differentiation efficiency evaluated along the culture time. The results show that, for bioreactor cultures, we were able to increase significantly the neuronal differentiation efficiency by 10-fold while reducing drastically, by 30%, the time required for the differentiation process. Conclusion The culture systems developed herein are robust and represent one-step-forward towards the development of integrated bioprocesses, bridging stem cell expansion and differentiation in fully controlled bioreactors.

  5. Integrable deformations of Lotka-Volterra systems

    Energy Technology Data Exchange (ETDEWEB)

    Ballesteros, Angel, E-mail: angelb@ubu.es [Departamento de Fisica, Universidad de Burgos, 09001 Burgos (Spain); Blasco, Alfonso, E-mail: ablasco@ubu.es [Departamento de Fisica, Universidad de Burgos, 09001 Burgos (Spain); Musso, Fabio, E-mail: fmusso@ubu.es [Departamento de Fisica, Universidad de Burgos, 09001 Burgos (Spain)

    2011-09-05

    The Hamiltonian structure of a class of three-dimensional (3D) Lotka-Volterra (LV) equations is revisited from a novel point of view by showing that the quadratic Poisson structure underlying its integrability structure is just a real three-dimensional Poisson-Lie group. As a consequence, the Poisson coalgebra map Δ{sup (2)} that is given by the group multiplication provides the keystone for the explicit construction of a new family of 3N-dimensional integrable systems that, under certain constraints, contain N sets of deformed versions of the 3D LV equations. Moreover, by considering the most generic Poisson-Lie structure on this group, a new two-parametric integrable perturbation of the 3D LV system through polynomial and rational perturbation terms is explicitly found. -- Highlights: → A new Poisson-Lie approach to the integrability of Lotka-Volterra system is given. → New integrable deformations of the 3D Lotka-Volterra system are obtained. → Integrable Lotka-Volterra-type equations in 3N dimensions are deduced.

  6. Transparent antennas for solar cell integration

    Science.gov (United States)

    Yasin, Tursunjan

    Transparent patch antennas are microstrip patch antennas that have a certain level of optical transparency. Highly transparent patch antennas are potentially suitable for integration with solar panels of small satellites, which are becoming increasingly important in space exploration. Traditional patch antennas employed on small satellites compete with solar cells for surface area. However, a transparent patch antenna can be placed directly on top of solar cells and resolve the issue of competing for limited surface real estate. For such an integration, a high optical transparency of the patch antenna is required from the solar cells' point of view. On the other hand, the antenna should possess at least acceptable radiation properties at the same time. This dissertation focuses on some of the most important concerns from the perspective of small satellite applications. For example, an optimization method to simultaneously improve both optical transparency and radiation efficiency of the antenna is studied. Active integrated antenna design method is extended to meshed patch applications in an attempt to improve the overall power efficiency of the front end communication subsystem. As is well known, circular polarization is immune from Faraday rotation effect in the ionosphere and thus can avoid a 3-dB loss in geo-satellite communication. Therefore, this research also aims to present design methods for circularly polarized meshed patch antennas. Moreover, a meshed patch antenna capable of supporting a high communication data rate is investigated. Lastly, other types of transparent patch antennas are also analyzed and compared to meshed patches. In summary, many properties of transparent patch antennas are examined in order to meet different design requirements.

  7. Integrated waste and water management system

    Science.gov (United States)

    Murray, R. W.; Sauer, R. L.

    1986-01-01

    The performance requirements of the NASA Space Station have prompted a reexamination of a previously developed integrated waste and water management system that used distillation and catalytic oxydation to purify waste water, and microbial digestion and incineration for waste solids disposal. This system successfully operated continuously for 206 days, for a 4-man equivalent load of urine, feces, wash water, condensate, and trash. Attention is given to synergisms that could be established with other life support systems, in the cases of thermal integration, design commonality, and novel technologies.

  8. Integrated waste and water management system

    Science.gov (United States)

    Murray, R. W.; Sauer, R. L.

    1986-01-01

    The performance requirements of the NASA Space Station have prompted a reexamination of a previously developed integrated waste and water management system that used distillation and catalytic oxydation to purify waste water, and microbial digestion and incineration for waste solids disposal. This system successfully operated continuously for 206 days, for a 4-man equivalent load of urine, feces, wash water, condensate, and trash. Attention is given to synergisms that could be established with other life support systems, in the cases of thermal integration, design commonality, and novel technologies.

  9. Engineering the System and Technical Integration

    Science.gov (United States)

    Blair, J. C.; Ryan, R. S.; Schutzenhofer, L. A.

    2011-01-01

    Approximately 80% of the problems encountered in aerospace systems have been due to a breakdown in technical integration and/or systems engineering. One of the major challenges we face in designing, building, and operating space systems is: how is adequate integration achieved for the systems various functions, parts, and infrastructure? This Contractor Report (CR) deals with part of the problem of how we engineer the total system in order to achieve the best balanced design. We will discuss a key aspect of this question - the principle of Technical Integration and its components, along with management and decision making. The CR will first provide an introduction with a discussion of the Challenges in Space System Design and meeting the challenges. Next is an overview of Engineering the System including Technical Integration. Engineering the System is expanded to include key aspects of the Design Process, Lifecycle Considerations, etc. The basic information and figures used in this CR were presented in a NASA training program for Program and Project Managers Development (PPMD) in classes at Georgia Tech and at Marshall Space Flight Center (MSFC). Many of the principles and illustrations are extracted from the courses we teach for MSFC.

  10. Geometric quenches in quantum integrable systems

    NARCIS (Netherlands)

    Mossel, J.; Palacios, G.; Caux, J.S.

    2010-01-01

    We consider the generic problem of suddenly changing the geometry of an integrable, one-dimensional many-body quantum system. We show how the physics of an initial quantum state released into a bigger system can be completely described within the framework of the algebraic Bethe ansatz, by providing

  11. Editorial: Principles of Integrated Agricultural Systems

    Science.gov (United States)

    Rapid changes occurring in the agricultural environment are placing increased demands on producers. To respond to these demands, farmers need to manage their systems by reducing risk, while retaining management flexibility. Integrated agricultural systems have the potential to meet these objectives....

  12. Academic Information Systems: From Segregation to Integration.

    Science.gov (United States)

    Bernbom, Gerald; And Others

    1992-01-01

    Through integration of administrative information systems across diverse technology platforms and opening access to institutional data, Indiana University has begun to expand the concept of academic information systems. The university's experience has resulted in conclusions and guidelines for other institutions to use in AIS planning and…

  13. Integrating systems biology models and biomedical ontologies

    Directory of Open Access Journals (Sweden)

    de Bono Bernard

    2011-08-01

    Full Text Available Abstract Background Systems biology is an approach to biology that emphasizes the structure and dynamic behavior of biological systems and the interactions that occur within them. To succeed, systems biology crucially depends on the accessibility and integration of data across domains and levels of granularity. Biomedical ontologies were developed to facilitate such an integration of data and are often used to annotate biosimulation models in systems biology. Results We provide a framework to integrate representations of in silico systems biology with those of in vivo biology as described by biomedical ontologies and demonstrate this framework using the Systems Biology Markup Language. We developed the SBML Harvester software that automatically converts annotated SBML models into OWL and we apply our software to those biosimulation models that are contained in the BioModels Database. We utilize the resulting knowledge base for complex biological queries that can bridge levels of granularity, verify models based on the biological phenomenon they represent and provide a means to establish a basic qualitative layer on which to express the semantics of biosimulation models. Conclusions We establish an information flow between biomedical ontologies and biosimulation models and we demonstrate that the integration of annotated biosimulation models and biomedical ontologies enables the verification of models as well as expressive queries. Establishing a bi-directional information flow between systems biology and biomedical ontologies has the potential to enable large-scale analyses of biological systems that span levels of granularity from molecules to organisms.

  14. CTBT integrated verification system evaluation model supplement

    Energy Technology Data Exchange (ETDEWEB)

    EDENBURN,MICHAEL W.; BUNTING,MARCUS; PAYNE JR.,ARTHUR C.; TROST,LAWRENCE C.

    2000-03-02

    Sandia National Laboratories has developed a computer based model called IVSEM (Integrated Verification System Evaluation Model) to estimate the performance of a nuclear detonation monitoring system. The IVSEM project was initiated in June 1994, by Sandia's Monitoring Systems and Technology Center and has been funded by the U.S. Department of Energy's Office of Nonproliferation and National Security (DOE/NN). IVSEM is a simple, ''top-level,'' modeling tool which estimates the performance of a Comprehensive Nuclear Test Ban Treaty (CTBT) monitoring system and can help explore the impact of various sensor system concepts and technology advancements on CTBT monitoring. One of IVSEM's unique features is that it integrates results from the various CTBT sensor technologies (seismic, in sound, radionuclide, and hydroacoustic) and allows the user to investigate synergy among the technologies. Specifically, IVSEM estimates the detection effectiveness (probability of detection), location accuracy, and identification capability of the integrated system and of each technology subsystem individually. The model attempts to accurately estimate the monitoring system's performance at medium interfaces (air-land, air-water) and for some evasive testing methods such as seismic decoupling. The original IVSEM report, CTBT Integrated Verification System Evaluation Model, SAND97-25 18, described version 1.2 of IVSEM. This report describes the changes made to IVSEM version 1.2 and the addition of identification capability estimates that have been incorporated into IVSEM version 2.0.

  15. Canadian Library Integrated Systems: Second Annual Survey.

    Science.gov (United States)

    Merilees, Bobbie

    1988-01-01

    Reports the results of a survey of the Canadian integrated library systems market. The analysis includes comparisons of large versus microcomputer-based installations by type of library and across all libraries, foreign sales by Canadian vendors, and trends in the library systems market. (CLB)

  16. ALEPH: A Bilingual Integrated Library System.

    Science.gov (United States)

    Steinberger, Naomi M.

    1994-01-01

    Discusses the ALEPH system at the library of the Jewish Theological Seminary (New York), a fully integrated library system with English/Hebrew capabilities. The three main areas of experimentation are considered: installation and evaluation; dealing with a foreign vendor; and creating a network. (JLB)

  17. Competitive Procurement of Integrated Library Systems.

    Science.gov (United States)

    Reader, Evan A.

    1989-01-01

    Describes the competitive bidding process used by California State University to successfully procure integrated library systems for 5 of its 19 campuses during 1 fiscal year. The procurements demonstrated that competitive bidding not only reduces overall cost of library systems, but also allows the buyer to achieve favorable contract provisions.…

  18. CTBT integrated verification system evaluation model supplement

    Energy Technology Data Exchange (ETDEWEB)

    EDENBURN,MICHAEL W.; BUNTING,MARCUS; PAYNE JR.,ARTHUR C.; TROST,LAWRENCE C.

    2000-03-02

    Sandia National Laboratories has developed a computer based model called IVSEM (Integrated Verification System Evaluation Model) to estimate the performance of a nuclear detonation monitoring system. The IVSEM project was initiated in June 1994, by Sandia's Monitoring Systems and Technology Center and has been funded by the U.S. Department of Energy's Office of Nonproliferation and National Security (DOE/NN). IVSEM is a simple, ''top-level,'' modeling tool which estimates the performance of a Comprehensive Nuclear Test Ban Treaty (CTBT) monitoring system and can help explore the impact of various sensor system concepts and technology advancements on CTBT monitoring. One of IVSEM's unique features is that it integrates results from the various CTBT sensor technologies (seismic, in sound, radionuclide, and hydroacoustic) and allows the user to investigate synergy among the technologies. Specifically, IVSEM estimates the detection effectiveness (probability of detection), location accuracy, and identification capability of the integrated system and of each technology subsystem individually. The model attempts to accurately estimate the monitoring system's performance at medium interfaces (air-land, air-water) and for some evasive testing methods such as seismic decoupling. The original IVSEM report, CTBT Integrated Verification System Evaluation Model, SAND97-25 18, described version 1.2 of IVSEM. This report describes the changes made to IVSEM version 1.2 and the addition of identification capability estimates that have been incorporated into IVSEM version 2.0.

  19. An integrated mobile system for port security

    Energy Technology Data Exchange (ETDEWEB)

    Cester, D. [Dipartimento di Fisica, Universita di Padova, Via F. Marzolo 8, Padova I-35131 (Italy); Fabris, D. [INFN Sezione di Padova, Via F. Marzolo 8, Padova I-35131 (Italy); Lunardon, M.; Moretto, S. [Dipartimento di Fisica, Universita di Padova, Via F. Marzolo 8, Padova I-35131 (Italy); Nebbia, G. [INFN Sezione di Padova, Via F. Marzolo 8, Padova I-35131 (Italy); Pesente, S.; Stevanato, L.; Viesti, G. [Dipartimento di Fisica, Universita di Padova, Via F. Marzolo 8, Padova I-35131 (Italy); Neri, F.; Petrucci, S.; Selmi, S.; Tintori, C. [CAEN S.p.A., Via Vetraia 11, I-55049, Viareggio LU (Italy)

    2011-07-01

    An integrated mobile system for port security is presented. The system is designed to perform active investigations, by using the tagged neutron inspection technique, of suspect dangerous materials as well as passive measurements of neutrons and gamma rays to search and identify radioactive and special nuclear materials. (authors)

  20. Recent advances in quantum integrable systems

    Energy Technology Data Exchange (ETDEWEB)

    Amico, L.; Belavin, A.; Buffenoir, E.; Castro Alvaredo, A.; Caudrelier, V.; Chakrabarti, A.; Corrig, E.; Crampe, N.; Deguchi, T.; Dobrev, V.K.; Doikou, A.; Doyon, B.; Feher, L.; Fioravanti, D.; Gohmann, F.; Hallnas, M.; Jimbo, M.; Konno, N.C.H.; Korchemsky, G.; Kulish, P.; Lassalle, M.; Maillet, J.M.; McCoy, B.; Mintchev, M.; Pakuliak, S.; Quano, F.Y.Z.; Ragnisco, R.; Ravanini, F.; Rittenberg, V.; Rivasseau, V.; Rossi, M.; Satta, G.; Sedrakyan, T.; Shiraishi, J.; Suzuki, N.C.J.; Yamada, Y.; Zamolodchikov, A.; Ishimoto, Y.; Nagy, Z.; Posta, S.; Sedra, M.B.; Zuevskiy, A.; Gohmann, F

    2005-07-01

    This meeting was dedicated to different aspects of the theory of quantum integrable systems. The organizers have intended to concentrate on topics related to the study of correlation functions, to systems with boundaries and to models at roots of unity. This document gathers the abstracts of 32 contributions, most of the contributions are accompanied by the set of transparencies.

  1. Integrating systems biology models and biomedical ontologies

    Science.gov (United States)

    2011-01-01

    Background Systems biology is an approach to biology that emphasizes the structure and dynamic behavior of biological systems and the interactions that occur within them. To succeed, systems biology crucially depends on the accessibility and integration of data across domains and levels of granularity. Biomedical ontologies were developed to facilitate such an integration of data and are often used to annotate biosimulation models in systems biology. Results We provide a framework to integrate representations of in silico systems biology with those of in vivo biology as described by biomedical ontologies and demonstrate this framework using the Systems Biology Markup Language. We developed the SBML Harvester software that automatically converts annotated SBML models into OWL and we apply our software to those biosimulation models that are contained in the BioModels Database. We utilize the resulting knowledge base for complex biological queries that can bridge levels of granularity, verify models based on the biological phenomenon they represent and provide a means to establish a basic qualitative layer on which to express the semantics of biosimulation models. Conclusions We establish an information flow between biomedical ontologies and biosimulation models and we demonstrate that the integration of annotated biosimulation models and biomedical ontologies enables the verification of models as well as expressive queries. Establishing a bi-directional information flow between systems biology and biomedical ontologies has the potential to enable large-scale analyses of biological systems that span levels of granularity from molecules to organisms. PMID:21835028

  2. Loop groups, Clusters, Dimers and Integrable systems

    CERN Document Server

    Fock, V V

    2014-01-01

    We describe a class of integrable systems on Poisson submanifolds of the affine Poisson-Lie groups $\\widehat{PGL}(N)$, which can be enumerated by cyclically irreducible elements the co-extended affine Weyl groups $(\\widehat{W}\\times \\widehat{W})^\\sharp$. Their phase spaces admit cluster coordinates, whereas the integrals of motion are cluster functions. We show, that this class of integrable systems coincides with the constructed by Goncharov and Kenyon out of dimer models on a two-dimensional torus and classified by the Newton polygons. We construct the correspondence between the Weyl group elements and polygons, demonstrating that each particular integrable model admits infinitely many realisations on the Poisson-Lie groups. We also discuss the particular examples, including the relativistic Toda chains and the Schwartz-Ovsienko-Tabachnikov pentagram map.

  3. Integrative Systems Biology: Elucidating Complex Traits

    DEFF Research Database (Denmark)

    Pers, Tune Hannes

    that body-mass index associated gene products coalesce onto distinct protein complexes, and show that these putative risk modules incriminate novel candidate obesitysusceptibility genes. e last overall line of research presented here, provides examples on how networks of human metabolism may serve...... traits and disease. e esis is structured as follows. Chapter  presents a few introductory remarks to integrative systems biology, and Chapter  gives a brief description of human genetic variation and GWA analysis. Chapters - present the main topics in the esis (integrative methodologies...... product itself. My doctoral studies have been focused on the development of integrative approaches to identify systemic risk-modifying and disease-causing patterns. ey have been rooted in the hypothesis that data integration of complementary data sets may yield additional etiologic insights compared...

  4. Fast integral methods for integrated optical systems simulations: a review

    Science.gov (United States)

    Kleemann, Bernd H.

    2015-09-01

    -functional profiles, very deep ones, very large ones compared to wavelength, or simple smooth profiles. This integral method with either trigonometric or spline collocation, iterative solver with O(N2) complexity, named IESMP, was significantly improved by an efficient mesh refinement, matrix preconditioning, Ewald summation method, and an exponentially convergent quadrature in 2006 by G. Schmidt and A. Rathsfeld from Weierstrass-Institute (WIAS) Berlin. The so-called modified integral method (MIM) is a modification of the IEM of D. Maystre and has been introduced by L. Goray in 1995. It has been improved for weak convergence problems in 2001 and it was the only commercial available integral method for a long time, known as PCGRATE. All referenced integral methods so far are for in-plane diffraction only, no conical diffraction was possible. The first integral method for gratings in conical mounting was developed and proven under very weak conditions by G. Schmidt (WIAS) in 2010. It works for separated interfaces and for inclusions as well as for interpenetrating interfaces and for a large number of thin and thick layers in the same stable way. This very fast method has then been implemented for parallel processing under Unix and Windows operating systems. This work gives an overview over the most important BIMs for grating diffraction. It starts by presenting the historical evolution of the methods, highlights their advantages and differences, and gives insight into new approaches and their achievements. It addresses future open challenges at the end.

  5. A Web-Based Integration Procedure for the Development of Reconfigurable Robotic Work-Cells

    OpenAIRE

    2013-01-01

    Concepts related to the development of reconfigurable manufacturing systems (RMS) and methodologies to provide the best practices in the processing industry and factory automation, such as system integration and web‐based technology, are major issues in designing next‐generation manufacturing systems (NGMS). Adaptable and integrable devices are crucial for the success of NGMS. In robotic cells the integration of manufacturing components is essential to accelerate system adaptability. Sensors,...

  6. Practice of the integrated endocrine system course

    Institute of Scientific and Technical Information of China (English)

    Wen-han MEI; Rong CAI

    2015-01-01

    The integrated curriculum is an important direction of the medical medical education reform under new situation and challenges of medical development.Shanghai Jiao Tong University School of Medicine has implemented the integrated curriculum reform in recent years.The endocrine system course is one of important intergrated courses and integrates relevant contents of multiple disciplines of basic medicine,diagnostics and medical imaging.Various teaching methods are adopted,such as classroom lecture,discussion,problembased learning,experimental lesson and clinical clerkship,etc.The teaching practice is carried on in several aspects:course arrangement,teaching methods,course website construction,teaching team construction and so on.

  7. ACADEMIC INTEGRITY SUPPORT SYSTEM FOR UKRAINIAN UNIVERSITIES

    Directory of Open Access Journals (Sweden)

    V. G. Sherstjuk

    2017-04-01

    Full Text Available Purpose. Developing the methodology for providing academic integrity in the university. The methodology is based on Web-oriented academic integrity support system, developed by the authors, which enters into the information system of learning process control. Academic integrity support system is aimed at maintaining academic integrity as a basic institutional value, which will help to reduce corruption, plagiarism and other types of academic dishonesty. Methodology. The methodology of problem to solve is based on the development of the information system of education process control with the integral elements of quality control. The information subsystem of academic integrity support is its basic part. Findings. The proposed information system allows us to fulfill the following levels: educational process monitoring; audit of internal processes, which is necessary for developing the effective quality control system; assessment of achievements of educational process participants; formalization of the interaction of educational process participants. The system is aimed at the development of new academic society based on the following principles: open access to the information, at which the access of wide audience to the information provides participation, forming the sense of responsibility and social control; transparency of the information, by which its relevance, quality, reliability are meant; responsibility of all members of educational process; measurability, at which any action in educational process should be measured; detail of describing the actions, results and processes; support, which is meant by automatic tools of the realization of the principles of open access to the information, transparency of the information, responsibility of all participants of educational process, measurability, detail, support. The practical realization of information system is based on the development of a common repository of university information. The

  8. Energy Systems Integration Partnerships: NREL + CSIRO

    Energy Technology Data Exchange (ETDEWEB)

    2016-12-01

    This fact sheet highlights work done at the ESIF in partnership with CSIRO. The Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australia's science agency, has teamed up with NREL to evaluate advanced control solutions for integrating solar energy in hybrid distributed generation applications. NREL and CSIRO demonstrated a plug-and play microgrid controller at the ESIF and also tested other control techniques for integrating solar power with Australian and U.S. electrical distribution systems.

  9. A fully integrated microbattery for an implantable microelectromechanical system

    Energy Technology Data Exchange (ETDEWEB)

    Albano, F. [Department of Material Science Engineering, University of Michigan, Ann Arbor, MI 48109 (United States); Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109 (United States); Lin, Y.S.; Blaauw, D.; Sylvester, D.M. [Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109 (United States); Wise, K.D. [Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109 (United States); Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 (United States); Sastry, A.M. [Department of Material Science Engineering, University of Michigan, Ann Arbor, MI 48109 (United States); Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 (United States); Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109 (United States)

    2008-12-01

    The Wireless Integrated Microsystems Engineering Research Center's Intraocular Sensor (WIMS-ERC IOS) was studied as a model system for an integrated, autonomous implantable device. In the present study, we had four objectives: (1) select and designing an optimized power supply for the WIMS-IOS; (2) develop a fabrication technique allowing small scale, low-cost, and integrable fabrication for CMOS systems, and experimentally demonstrate a microscopic power source; (3) map capacity and lifetime of several fabricated microbatteries; (4) determine the effects of miniaturization on capacity, lifetime and device architecture. Physical vapor deposition (PVD) was used to deposit thin layers ({<=}1 {mu}m) of metal sequentially onto glass substrates (SiO{sub 2}, as used in the device). To map the influence of size over cell capacity and cycle life, we fabricated and tested five stand-alone cells using a Solartron {sup registered} 1470E battery tester and a Maccor {sup registered} 4000 series tester. A sixth battery was fabricated to investigate the effects of system integration, variable discharge rate and size reduction simultaneously. The highest experimental capacity among the larger cells O(cm{sup 2}) was 100 {mu}Ah, achieved by IOS-C-1 at 250 {mu}A (1.4 C) discharge. Among O(mm{sup 2}) cells, IOS-M-1 achieved the highest capacity (2.75 {mu}Ah, {proportional_to}76% of theoretical) at 2.5 {mu}A discharge (0.7 C rate). (author)

  10. Syngas generation from n-butane with an integrated MEMS assembly for gas processing in micro-solid oxide fuel cell systems.

    Science.gov (United States)

    Bieberle-Hütter, A; Santis-Alvarez, A J; Jiang, B; Heeb, P; Maeder, T; Nabavi, M; Poulikakos, D; Niedermann, P; Dommann, A; Muralt, P; Bernard, A; Gauckler, L J

    2012-11-21

    An integrated system of a microreformer and a carrier allowing for syngas generation from liquefied petroleum gas (LPG) for micro-SOFC application is discussed. The microreformer with an overall size of 12.7 mm × 12.7 mm × 1.9 mm is fabricated with micro-electro-mechanical system (MEMS) technologies. As a catalyst, a special foam-like material made from ceria-zirconia nanoparticles doped with rhodium is used to fill the reformer cavity of 58.5 mm(3). The microreformer is fixed onto a microfabricated structure with built-in fluidic channels and integrated heaters, the so-called functional carrier. It allows for thermal decoupling of the cold inlet gas and the hot fuel processing zone. Two methods for heating the microreformer are compared in this study: a) heating in an external furnace and b) heating with the two built-in heaters on the functional carrier. With both methods, high butane conversion rates of 74%-85% are obtained at around 550 °C. In addition, high hydrogen and carbon monoxide yields and selectivities are achieved. The results confirm those from classical lab reformers built without MEMS technology (N. Hotz et al., Chem. Eng. Sci., 2008, 63, 5193; N. Hotz et al., Appl. Catal., B, 2007, 73, 336). The material combinations and processing techniques enable syngas production with the present MEMS based microreformer with high performance for temperatures up to 700 °C. The functional carrier is the basis for a new platform, which can integrate the micro-SOFC membranes and the gas processing unit as subsystem of an entire micro-SOFC system.

  11. Outcome mapping for health system integration

    Directory of Open Access Journals (Sweden)

    Tsasis P

    2013-03-01

    Full Text Available Peter Tsasis,1 Jenna M Evans,2 David Forrest,3 Richard Keith Jones4 1School of Health Policy and Management, Faculty of Health, York University, Toronto, Canada; 2Institute of Health Policy, Management and Evaluation, Faculty of Medicine, University of Toronto, Canada; 3Global Vision Consulting Ltd, Victoria, Canada; 4R Keith Jones and Associates, Victoria, Canada Abstract: Health systems around the world are implementing integrated care strategies to improve quality, reduce or maintain costs, and improve the patient experience. Yet few practical tools exist to aid leaders and managers in building the prerequisites to integrated care, namely a shared vision, clear roles and responsibilities, and a common understanding of how the vision will be realized. Outcome mapping may facilitate stakeholder alignment on the vision, roles, and processes of integrated care delivery via participative and focused dialogue among diverse stakeholders on desired outcomes and enabling actions. In this paper, we describe an outcome-mapping exercise we conducted at a Local Health Integration Network in Ontario, Canada, using consensus development conferences. Our preliminary findings suggest that outcome mapping may help stakeholders make sense of a complex system and foster collaborative capital, a resource that can support information sharing, trust, and coordinated change toward integration across organizational and professional boundaries. Drawing from the theoretical perspectives of complex adaptive systems and collaborative capital, we also outline recommendations for future outcome-mapping exercises. In particular, we emphasize the potential for outcome mapping to be used as a tool not only for identifying and linking strategic outcomes and actions, but also for studying the boundaries, gaps, and ties that characterize social networks across the continuum of care. Keywords: integrated care, integrated delivery systems, complex adaptive systems, social capital

  12. Battery management systems with thermally integrated fire suppression

    Science.gov (United States)

    Bandhauer, Todd M.; Farmer, Joseph C.

    2017-07-11

    A thermal management system is integral to a battery pack and/or individual cells. It relies on passive liquid-vapor phase change heat removal to provide enhanced thermal protection via rapid expulsion of inert high pressure refrigerant during abnormal abuse events and can be integrated with a cooling system that operates during normal operation. When a thermal runaway event occurs and sensed by either active or passive sensors, the high pressure refrigerant is preferentially ejected through strategically placed passages within the pack to rapidly quench the battery.

  13. A dual-mediated liposomal drug delivery system targeting the brain: rational construction, integrity evaluation across the blood–brain barrier, and the transporting mechanism to glioma cells

    Science.gov (United States)

    Liu, Chang; Liu, Xiao-Na; Wang, Gui-Ling; Hei, Yu; Meng, Shuai; Yang, Ling-Fei; Yuan, Lan; Xie, Ying

    2017-01-01

    As the global population ages, cancer rates increase worldwide, and degenerative diseases of the central nervous system (CNS), brain tumors, and inflammation threaten human health more frequently. We designed a dual-mediated (receptor-mediated and adsorption-mediated) liposome, named transferrin–cell penetrating peptide–sterically stabilized liposome (TF-CPP-SSL), to improve therapy for gliomas through combining molecular recognition of transferrin receptors (TF-Rs) on the blood–brain barrier (BBB) and glioma cells with the internalization and lysosomal escaping ability of CPP. Based on the systematic investigation of structure–activity relations on the cellular level, we constructed TF-CPP-SSL rationally by conjugating TF and CPP moieties to the liposomes via PEG3.4K and PEG2.0K, respectively, and found the optimum densities of TF and CPP were 1.8% and 4%, respectively. These liposomes had the highest targeting efficacy for brain microvascular endothelial cell and C6 cell uptake but avoided capture by normal cells. Fluorescence resonance energy transfer technology and coculture models of BBB and glioma C6 cells indicated that TF-CPP-SSL was transported across the BBB without drug leakage, liposome breakup, or cleavage of ligand. TF-CPP-SSL offered advantages for crossing the BBB and entering into glioma C6 cells. Real-time confocal viewing revealed that TF-CPP-SSL was entrapped in endosomes of glioma C6 cells and then escaped from lysosomes successfully to release the liposomal contents into the cytosol. Entrapped contents, such as doxorubicin, could then enter the nucleus to exert pharmacological effects. PMID:28405164

  14. Multiscale systems integration in the eye.

    Science.gov (United States)

    Jacobs, Marc D

    2009-01-01

    A series of research topics on the eye is reviewed with the aim of illustrating how integrative and systems-biological approaches can be used to understand complex properties and functions of ocular tissues. Emphasis is placed on the diversity of physiological systems represented in the eye, and the variety of approaches required to analyze those systems, both empirically and theoretically. Modeling and empirical studies reviewed focus mainly on problems that the eye presents, in the broad areas of biomechanics and fluid dynamics from the molecular to the whole-organ scale. Attention is given to the relevance of these studies in human disease and the current potential for development of medical therapies based upon a biophysical, integrative modeling approach. The creation of a multiscale hierarchy of numerical models of the eye is proposed as an important and unifying aim of integrative eye research.

  15. From Social Simulation to Integrative System Design

    CERN Document Server

    Helbing, Dirk

    2010-01-01

    As the recent financial crisis showed, today there is a strong need to gain "ecological perspective" of all relevant interactions in socio-economic-techno-environmental systems. For this, we suggested to set-up a network of Centers for integrative systems design, which shall be able to run all potentially relevant scenarios, identify causality chains, explore feedback and cascading effects for a number of model variants, and determine the reliability of their implications (given the validity of the underlying models). They will be able to detect possible negative side effect of policy decisions, before they occur. The Centers belonging to this network of Integrative Systems Design Centers would be focused on a particular field, but they would be part of an attempt to eventually cover all relevant areas of society and economy and integrate them within a "Living Earth Simulator". The results of all research activities of such Centers would be turned into informative input for political Decision Arenas. For exam...

  16. Cell Radiation Experiment System

    Science.gov (United States)

    Morrison, Dennis R.

    2010-01-01

    The cell radiation experiment system (CRES) is a perfused-cell culture apparatus, within which cells from humans or other animals can (1) be maintained in homeostasis while (2) being exposed to ionizing radiation during controlled intervals and (3) being monitored to determine the effects of radiation and the repair of radiation damage. The CRES can be used, for example, to determine effects of drug, radiation, and combined drug and radiation treatments on both normal and tumor cells. The CRES can also be used to analyze the effects of radiosensitive or radioprotectant drugs on cells subjected to radiation. The knowledge gained by use of the CRES is expected to contribute to the development of better cancer treatments and of better protection for astronauts, medical-equipment operators, and nuclear-power-plant workers, and others exposed frequently to ionizing radiation.

  17. Seamless integrated network system for wireless communication systems

    NARCIS (Netherlands)

    Wu, Gang; Mizuno, Mitsuhiko; Hase, Yoshihiro; Havinga, Paul J.M.

    2006-01-01

    To create a network that connects a plurality of wireless communication systems to create optimal systems for various environments, and that seamlessly integrates the resulting systems together in order to provide more efficient and advanced service in general. A network system that can seamlessly i

  18. Seamless integrated network system for wireless communication systems

    NARCIS (Netherlands)

    Wu, Gang; Mizuno, Mitsuhiko; Hase, Yoshihiro; Havinga, Paul J.M.

    2002-01-01

    To create a network that connects a plurality of wireless communication systems to create optimal systems for various environments, and that seamlessly integrates the resulting systems together in order to provide more efficient and advanced service in general. A network system that can seamlessly i

  19. INTEGRATED HSEQ MANAGEMENT SYSTEMS: DEVELOPMENTS AND TRENDS

    Directory of Open Access Journals (Sweden)

    Osmo Kauppila

    2015-06-01

    Full Text Available The integration of health and safety, environmental and quality (HSEQ management systems has become a current topic in the 21st century, as the need for systems thinking has grown along with the number of management system standards. This study aims to map current developments and trends in integrated HSEQ management. Three viewpoints are taken: the current state of the main HSEQ management standards, research literature on integrated management systems (IMS, and a case study of an industry-led HSEQ cluster in Northern Finland. The results demonstrate that some of the most prominent current trends are the harmonization of the high level structure of management systems by ISO, the evaluation of IMS, accounting for the supply chain in HSEQ issues, and sustainability and risk management. The results of the study can be used by practitioners to get a view of the current state of HSEQ management systems and their integration, and by researchers to seek out potential directions for HSEQ and IMS related research.

  20. An integrated multivariable artificial pancreas control system.

    Science.gov (United States)

    Turksoy, Kamuran; Quinn, Lauretta T; Littlejohn, Elizabeth; Cinar, Ali

    2014-05-01

    The objective was to develop a closed-loop (CL) artificial pancreas (AP) control system that uses continuous measurements of glucose concentration and physiological variables, integrated with a hypoglycemia early alarm module to regulate glucose concentration and prevent hypoglycemia. Eleven open-loop (OL) and 9 CL experiments were performed. A multivariable adaptive artificial pancreas (MAAP) system was used for the first 6 CL experiments. An integrated multivariable adaptive artificial pancreas (IMAAP) system consisting of MAAP augmented with a hypoglycemia early alarm system was used during the last 3 CL experiments. Glucose values and physical activity information were measured and transferred to the controller every 10 minutes and insulin suggestions were entered to the pump manually. All experiments were designed to be close to real-life conditions. Severe hypoglycemic episodes were seen several times during the OL experiments. With the MAAP system, the occurrence of severe hypoglycemia was decreased significantly (P < .01). No hypoglycemia was seen with the IMAAP system. There was also a significant difference (P < .01) between OL and CL experiments with regard to percentage of glucose concentration (54% vs 58%) that remained within target range (70-180 mg/dl). Integration of an adaptive control and hypoglycemia early alarm system was able to keep glucose concentration values in target range in patients with type 1 diabetes. Postprandial hypoglycemia and exercise-induced hypoglycemia did not occur when this system was used. Physical activity information improved estimation of the blood glucose concentration and effectiveness of the control system.

  1. Understanding Patterns for System-of-Systems Integration

    DEFF Research Database (Denmark)

    Kazman, Rick; Nielsen, Claus Ballegård; Schmid, Klaus

    Creating a successful system of systems—one that meets the needs of its stakeholders today and can evolve and scale to sustain those stakeholders into the future—is a very complex engineering challenge. In a system of systems (SoS), one of the biggest challenges is in achieving cooperation...... and interoperation among systems through some form of system integration. Previous work has approached the information system integration challenge in a generic way, not specific to a SoS context, or has provided only a limited range of solutions. This technical report discusses how an IT architect can address...

  2. Integrated transport and renewable energy systems

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; Lund, Henrik; Nørgaard, P.

    2008-01-01

    No single technology can solve the problem of ever increasing CO2 emissions from transport. Here, a coherent effort to integrate transport into energyplanning is proposed, using multiple means promoting sustainable transport. It is concluded that a 100 per cent renewable energy transport system...... is possible but is connected to significant challenges in the path towards it. Biomass is a limited resource and it is important to avoid effecting the production of food. The integration of the transport with the energy system is crucial as is a multi-pronged strategy. Short term solutions have to consider...

  3. System integration test plan for HANDI 2000 business management system

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, D.

    1998-08-24

    This document presents the system integration test plan for the Commercial-Off-The-Shelf, PassPort and PeopleSoft software, and custom software created to work with the COTS products. The PP software is an integrated application for AP, Contract Management, Inventory Management, Purchasing and Material Safety Data Sheet. The PS software is an integrated application for Project Costing, General Ledger, Human Resources/Training, Payroll, and Base Benefits.

  4. Maximum Temperature Detection System for Integrated Circuits

    Science.gov (United States)

    Frankiewicz, Maciej; Kos, Andrzej

    2015-03-01

    The paper describes structure and measurement results of the system detecting present maximum temperature on the surface of an integrated circuit. The system consists of the set of proportional to absolute temperature sensors, temperature processing path and a digital part designed in VHDL. Analogue parts of the circuit where designed with full-custom technique. The system is a part of temperature-controlled oscillator circuit - a power management system based on dynamic frequency scaling method. The oscillator cooperates with microprocessor dedicated for thermal experiments. The whole system is implemented in UMC CMOS 0.18 μm (1.8 V) technology.

  5. Informatics Solutions for Smart Metering Systems Integration

    Directory of Open Access Journals (Sweden)

    Simona-Vasilica OPREA

    2015-01-01

    Full Text Available In this paper different aspects regarding smart metering systems integration have been depicted. Smart metering systems, renewable energy sources integration and advanced tariff systems implementation require informatics solution that could automatically collect and process data, forecast the behavior of electricity consumers, analyze trends regarding electricity prices, optimize the consumption of consumers, provide friendly interfaces, etc. They are advanced technologies that represent solutions for insufficient conventional primary energy sources, gas emissions, dependency on energy sources located outside European Union and issues related to energy efficiency. This paper mainly describes several informatics solutions correlated with operational requirements for smart metering system and our proposal for simplified architecture of smart metering systems, with three distinct levels (base level, middle level and top level and load profile calculation methods.

  6. CTBT Integrated Verification System Evaluation Model

    Energy Technology Data Exchange (ETDEWEB)

    Edenburn, M.W.; Bunting, M.L.; Payne, A.C. Jr.

    1997-10-01

    Sandia National Laboratories has developed a computer based model called IVSEM (Integrated Verification System Evaluation Model) to estimate the performance of a nuclear detonation monitoring system. The IVSEM project was initiated in June 1994, by Sandia`s Monitoring Systems and Technology Center and has been funded by the US Department of Energy`s Office of Nonproliferation and National Security (DOE/NN). IVSEM is a simple, top-level, modeling tool which estimates the performance of a Comprehensive Nuclear Test Ban Treaty (CTBT) monitoring system and can help explore the impact of various sensor system concepts and technology advancements on CTBT monitoring. One of IVSEM`s unique features is that it integrates results from the various CTBT sensor technologies (seismic, infrasound, radionuclide, and hydroacoustic) and allows the user to investigate synergy among the technologies. Specifically, IVSEM estimates the detection effectiveness (probability of detection) and location accuracy of the integrated system and of each technology subsystem individually. The model attempts to accurately estimate the monitoring system`s performance at medium interfaces (air-land, air-water) and for some evasive testing methods such as seismic decoupling. This report describes version 1.2 of IVSEM.

  7. Integration of Standardized Management Systems: A Dilemma?

    Directory of Open Access Journals (Sweden)

    Manuel Ferreira Rebelo

    2015-06-01

    Full Text Available The growing proliferation of management systems standards (MSSs, and their individualized implementation, is a real problem faced by organizations. On the other hand, MSSs are aimed at improving efficiency and effectiveness of organizational responses in order to satisfy the requirements, needs and expectations of the stakeholders. Each organization has its own identity and this is an issue that cannot be neglected; hence, two possible approaches can be attended. First, continue with the implementation of individualized management systems (MSs; or, integrate the several MSSs versus related MSs into an integrated management system (IMS. Therefore, in this context, organizations are faced with a dilemma, as a result of the increasing proliferation and diversity of MSSs. This paper takes into account the knowledge gained through a case study conducted in the context of a Portuguese company and unveils some of the advantages and disadvantages of integration. A methodology is also proposed and presented to support organizations in developing and structuring the integration process of their individualized MSs, and consequently minimize problems that are generators of inefficiencies, value destruction and loss of competitiveness. The obtained results provide relevant information that can support Top Management decision in solving that dilemma and consequently promote a successful integration, including a better control of business risks associated to MSSs requirements and enhancing sustainable performance, considering the context in which organizations operate.

  8. Life-cycle analysis of product integrated polymer solar cells

    DEFF Research Database (Denmark)

    Espinosa Martinez, Nieves; García-Valverde, Rafael; Krebs, Frederik C

    2011-01-01

    economics through design to functionality. An LCA study was performed to quantify the energy use and greenhouse gas (GHG) emissions from electricity use in the manufacture of a light-weight lamp based on a plastic foil, a lithium-polymer battery, a polymer solar cell, printed circuitry, blocking diode......A life cycle analysis (LCA) on a product integrated polymer solar module is carried out in this study. These assessments are well-known to be useful in developmental stages of a product in order to identify the bottlenecks for the up-scaling in its production phase for several aspects spanning from...... on the complete product integrated polymer solar cell. We have compared this portable lighting system with other lighting solutions, namely: a kerosene lamp in a remote rural area in Africa (Ethiopia), as a replacement of a silicon PV based lamp, in place of a torch with non-rechargeable lead-acid battery...

  9. Vlasov moments, integrable systems and singular solutions

    Energy Technology Data Exchange (ETDEWEB)

    Gibbons, John [Department of Mathematics, Imperial College London, London SW7 2AZ (United Kingdom); Holm, Darryl D. [Department of Mathematics, Imperial College London, London SW7 2AZ (United Kingdom); Computer and Computational Science Division, Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)], E-mail: d.holm@ic.ac.uk; Tronci, Cesare [Department of Mathematics, Imperial College London, London SW7 2AZ (United Kingdom); TERA Foundation for Oncological Hadrontherapy, 11 V. Puccini, Novara 28100 (Italy)

    2008-02-11

    The Vlasov equation governs the evolution of the single-particle probability distribution function (PDF) for a system of particles interacting without dissipation. Its singular solutions correspond to the individual particle motions. The operation of taking the moments of the Vlasov equation is a Poisson map. The resulting Lie-Poisson Hamiltonian dynamics of the Vlasov moments is found to be integrable is several cases. For example, the dynamics for coasting beams in particle accelerators is associated by a hodograph transformation to the known integrable Benney shallow-water equation. After setting the context, the Letter focuses on geodesic Vlasov moment equations. Continuum closures of these equations at two different orders are found to be integrable systems whose singular solutions characterize the geodesic motion of the individual particles.

  10. Smart power systems and renewable energy system integration

    CERN Document Server

    2016-01-01

    This monograph presents a wider spectrum of researches, developments, and case specific studies in the area of smart power systems and integration of renewable energy systems. The book will be for the benefit of a wider audience including researchers, postgraduate students, practicing engineers, academics, and regulatory policy makers. It covers a wide range of topics from fundamentals, and modelling and simulation aspects of traditional and smart power systems to grid integration of renewables; Micro Grids; challenges in planning and operation of a smart power system; risks, security, and stability in smart operation of a power system; and applied research in energy storage. .

  11. Integrated Virtual Assembly Process Planning System

    Institute of Scientific and Technical Information of China (English)

    LIU Jianhua; HOU Weiwei; HOU Weiwei; SHANG Wei; SHANG Wei; NING Ruxin; NING Ruxin

    2009-01-01

    Assembly process planning(APP) for complicated products is a time-consuming and difficult work with conventional method. Virtual assembly process planning(VAPP) provides engineers a new and efficiency way. Previous studies in VAPP are almost isolated and dispersive, and have not established a whole understanding and discussed key realization techniques of VAPP from a systemic and integrated view. The integrated virtual assembly process planning(IVAPP) system is a new virtual reality based engineering application, which offers engineers an efficient, intuitive, immersive and integrated method for assembly process planning in a virtual environment. Based on analysis the information integration requirement of VAPP, the architecture of IVAPP is proposed. Through the integrated structure, IVAPP system can realize information integration and workflow controlling. In order to model the assembly process in IVAPP, a hierarchical assembly task list(HATL) is presented, in which different assembly tasks for assembling different components are organized into a hierarchical list. A process-oriented automatic geometrical constraint recognition algorithm(AGCR) is proposed, so that geometrical constraints between components can be automatically recognized during the process of interactive assembling. At the same time, a progressive hierarchical reasoning(PHR) model is discussed. AGCR and PHR will greatly reduce the interactive workload. A discrete control node model(DCNM) for cable harness assembly planning in IVAPP is detailed. DCNM converts a cable harness into continuous flexed line segments connected by a series of section center points, and designs can realize cable harness planning through controlling those control nodes. Mechanical assemblies (such as transmission case and engine of automobile) are used to illustrate the feasibility of the proposed method and algorithms. The application of IVAPP system reveals advantages over the traditional assembly process planning method

  12. Systems Biology and Stem Cell Pluripotency

    DEFF Research Database (Denmark)

    Mashayekhi, Kaveh; Hall, Vanessa; Freude, Kristine

    2016-01-01

    Recent breakthroughs in stem cell biology have accelerated research in the area of regenerative medicine. Over the past years, it has become possible to derive patient-specific stem cells which can be used to generate different cell populations for potential cell therapy. Systems biological...... modeling of stem cell pluripotency and differentiation have largely been based on prior knowledge of signaling pathways, gene regulatory networks, and epigenetic factors. However, there is a great need to extend the complexity of the modeling and to integrate different types of data, which would further...... improve systems biology and its uses in the field. In this chapter, we first give a general background on stem cell biology and regenerative medicine. Stem cell potency is introduced together with the hierarchy of stem cells ranging from pluripotent embryonic stem cells (ESCs) and induced pluripotent stem...

  13. NIF Integrated Computer Controls System Description

    Energy Technology Data Exchange (ETDEWEB)

    VanArsdall, P.

    1998-01-26

    This System Description introduces the NIF Integrated Computer Control System (ICCS). The architecture is sufficiently abstract to allow the construction of many similar applications from a common framework. As discussed below, over twenty software applications derived from the framework comprise the NIF control system. This document lays the essential foundation for understanding the ICCS architecture. The NIF design effort is motivated by the magnitude of the task. Figure 1 shows a cut-away rendition of the coliseum-sized facility. The NIF requires integration of about 40,000 atypical control points, must be highly automated and robust, and will operate continuously around the clock. The control system coordinates several experimental cycles concurrently, each at different stages of completion. Furthermore, facilities such as the NIF represent major capital investments that will be operated, maintained, and upgraded for decades. The computers, control subsystems, and functionality must be relatively easy to extend or replace periodically with newer technology.

  14. Eigenstate Gibbs Ensemble in Integrable Quantum Systems

    CERN Document Server

    Nandy, Sourav; Das, Arnab; Dhar, Abhishek

    2016-01-01

    The Eigenstate Thermalization Hypothesis implies that for a thermodynamically large system in one of its eigenstates, the reduced density matrix describing any finite subsystem is determined solely by a set of {\\it relevant} conserved quantities. In a generic system, only the energy plays that role and hence eigenstates appear locally thermal. Integrable systems, on the other hand, possess an extensive number of such conserved quantities and hence the reduced density matrix requires specification of an infinite number of parameters (Generalized Gibbs Ensemble). However, here we show by unbiased statistical sampling of the individual eigenstates with a given finite energy density, that the local description of an overwhelming majority of these states of even such an integrable system is actually Gibbs-like, i.e. requires only the energy density of the eigenstate. Rare eigenstates that cannot be represented by the Gibbs ensemble can also be sampled efficiently by our method and their local properties are then s...

  15. NIF Integrated Computer Controls System Description

    Energy Technology Data Exchange (ETDEWEB)

    VanArsdall, P.

    1998-01-26

    This System Description introduces the NIF Integrated Computer Control System (ICCS). The architecture is sufficiently abstract to allow the construction of many similar applications from a common framework. As discussed below, over twenty software applications derived from the framework comprise the NIF control system. This document lays the essential foundation for understanding the ICCS architecture. The NIF design effort is motivated by the magnitude of the task. Figure 1 shows a cut-away rendition of the coliseum-sized facility. The NIF requires integration of about 40,000 atypical control points, must be highly automated and robust, and will operate continuously around the clock. The control system coordinates several experimental cycles concurrently, each at different stages of completion. Furthermore, facilities such as the NIF represent major capital investments that will be operated, maintained, and upgraded for decades. The computers, control subsystems, and functionality must be relatively easy to extend or replace periodically with newer technology.

  16. Integral lightning protection system in petroleum facilities

    Energy Technology Data Exchange (ETDEWEB)

    Torres, Horacio; Gallego, Luis; Montana, Johny; Younes, Camilo; Rondon, Daniel; Gonzalez, Diego; Herrera, Javier; Perez, Ernesto; Vargas, Mauricio; Quintana, Carlos; Salgado, Milton [Universidad Nacional de Colombia, Bogota (Colombia)]. E-mail: paas@paas.unal.edu.co

    2001-07-01

    This paper presents an Integral Lightning Protection System, focused mainly in petroleum facilities and applied to a real case in Colombia, South America. As introduction it is presented a summary of the incidents happened in last years, a diagnosis and the proposal of solution. Finally, as part of the analysis, a lightning risk assessment for the Central Process Facility is showed. (author)

  17. Integrated Propulsion Data System Public Web Site

    Science.gov (United States)

    Hamilton, Kimberly

    2001-01-01

    The Integrated Propulsion Data System's (IPDS) focus is to provide technologically-advanced philosophies of doing business at SSC that will enhance the existing operations, engineering and management strategies and provide insight and metrics to assess their daily impacts, especially as related to the Propulsion Test Directorate testing scenarios for the 21st Century.

  18. Facility Requirements for Integrated Learning Systems.

    Science.gov (United States)

    Knirk, Frederick G.

    1992-01-01

    Discusses features in the physical environment that need to be considered for integrated learning systems (ILSs). Highlights include ergonomics; lighting, including contrast and colors; space, furniture, and equipment, including keyboard, monitor, software, and printer; ambient noise and acoustics; temperature, humidity, and air quality control;…

  19. Integration of stochastic generation in power systems

    NARCIS (Netherlands)

    Papaefthymiou, G.

    2007-01-01

    Stochastic Generation is the electrical power production by the use of an uncontrollable prime energy mover, corresponding mainly to renewable energy sources. For the large-scale integration of stochastic generation in power systems, methods are necessary for the modeling of power generation

  20. Integration of stochastic generation in power systems

    NARCIS (Netherlands)

    Papaefthymiou, G.

    2007-01-01

    Stochastic Generation is the electrical power production by the use of an uncontrollable prime energy mover, corresponding mainly to renewable energy sources. For the large-scale integration of stochastic generation in power systems, methods are necessary for the modeling of power generation uncerta

  1. Monolithically integrated absolute frequency comb laser system

    Energy Technology Data Exchange (ETDEWEB)

    Wanke, Michael C.

    2016-07-12

    Rather than down-convert optical frequencies, a QCL laser system directly generates a THz frequency comb in a compact monolithically integrated chip that can be locked to an absolute frequency without the need of a frequency-comb synthesizer. The monolithic, absolute frequency comb can provide a THz frequency reference and tool for high-resolution broad band spectroscopy.

  2. Integrated Model of Bioenergy and Agriculture System

    DEFF Research Database (Denmark)

    Sigurjonsson, Hafthor Ægir; Elmegaard, Brian; Clausen, Lasse Røngaard

    2015-01-01

    approach that builds on Life Cycle Inventory and carries out Life Cycle Impact Assessment for a con- sequential Life Cycle Assessment on integrated bioenergy and agriculture systems. The model framework is built in Python which connects various freely available soft- ware that handle different aspects...

  3. Integration of stochastic generation in power systems

    NARCIS (Netherlands)

    Papaefthymiou, G.

    2007-01-01

    Stochastic Generation is the electrical power production by the use of an uncontrollable prime energy mover, corresponding mainly to renewable energy sources. For the large-scale integration of stochastic generation in power systems, methods are necessary for the modeling of power generation uncerta

  4. Global Properties of Integrable Hamiltonian Systems

    NARCIS (Netherlands)

    Lukina, O.V.; Takens, F.; Broer, H.W.

    2008-01-01

    This paper deals with Lagrangian bundles which are symplectic torus bundles that occur in integrable Hamiltonian systems. We review the theory of obstructions to triviality, in particular monodromy, as well as the ensuing classification problems which involve the Chern and Lagrange class. Our

  5. Global Properties of Integrable Hamiltonian Systems

    NARCIS (Netherlands)

    Lukina, O.V.; Takens, F.; Broer, H.W.

    2008-01-01

    This paper deals with Lagrangian bundles which are symplectic torus bundles that occur in integrable Hamiltonian systems. We review the theory of obstructions to triviality, in particular monodromy, as well as the ensuing classification problems which involve the Chern and Lagrange class. Our approa

  6. Integrated computer control system architectural overview

    Energy Technology Data Exchange (ETDEWEB)

    Van Arsdall, P.

    1997-06-18

    This overview introduces the NIF Integrated Control System (ICCS) architecture. The design is abstract to allow the construction of many similar applications from a common framework. This summary lays the essential foundation for understanding the model-based engineering approach used to execute the design.

  7. Exactly integrable analogue of a one-dimensional gravitating system

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Bruce N. [Department of Physics and Astronomy, Texas Christian University, Fort Worth, TX 76129 (United States)]. E-mail: b.miller@tcu.edu; Yawn, Kenneth R. [Department of Physics and Astronomy, Texas Christian University, Fort Worth, TX 76129 (United States); Maier, Bill [Department of Physics and Astronomy, Texas Christian University, Fort Worth, TX 76129 (United States)

    2005-10-10

    Exchange symmetry in acceleration partitions the configuration space of an N particle one-dimensional gravitational system (OGS) into N{exclamation_point} equivalent cells. We take advantage of the resulting small angular separation between the forces in neighboring cells to construct a related integrable version of the system that takes the form of a central force problem in N-1 dimensions. The properties of the latter, including the construction of trajectories and possible continuum limits, are developed. Dynamical simulation is employed to compare the two models. For some initial conditions, excellent agreement is observed.

  8. Lean Big Data integration in systems biology and systems pharmacology.

    Science.gov (United States)

    Ma'ayan, Avi; Rouillard, Andrew D; Clark, Neil R; Wang, Zichen; Duan, Qiaonan; Kou, Yan

    2014-09-01

    Data sets from recent large-scale projects can be integrated into one unified puzzle that can provide new insights into how drugs and genetic perturbations applied to human cells are linked to whole-organism phenotypes. Data that report how drugs affect the phenotype of human cell lines and how drugs induce changes in gene and protein expression in human cell lines can be combined with knowledge about human disease, side effects induced by drugs, and mouse phenotypes. Such data integration efforts can be achieved through the conversion of data from the various resources into single-node-type networks, gene-set libraries, or multipartite graphs. This approach can lead us to the identification of more relationships between genes, drugs, and phenotypes as well as benchmark computational and experimental methods. Overall, this lean 'Big Data' integration strategy will bring us closer toward the goal of realizing personalized medicine.

  9. Urban energy systems an integrated approach

    CERN Document Server

    Keirstead, James

    2013-01-01

    Energy demands of cities need to be met more sustainably. This book analyses the technical and social systems that satisfy these needs and asks how methods can be put into practice to achieve this.Drawing on analytical tools and case studies developed at Imperial College London, the book presents state-of-the-art techniques for examining urban energy systems as integrated systems of technologies, resources, and people.Case studies include:a history of the evolution of London's urban energy system, from pre-history to present daya history of the growth of d

  10. Integrating commercial and legacy systems with EPICS

    Energy Technology Data Exchange (ETDEWEB)

    Hill, J.O. [Los Alamos National Lab., NM (United States); Kasemir, K.U. [Univ. Osnabrueck (Germany). Fachbereich Physik; Kowalkowski, J.B. [Argonne National Lab., IL (United States)

    1997-09-01

    The Experimental Physics and Industrial Control System (EPICS) is a software toolkit, developed by a worldwide collaboration, which significantly reduces the level of effort required to implement a new control system. Recent developments now also significantly reduce the level of effort required to integrate commercial, legacy and/or site-authored control systems with EPICS. This paper will illustrate with an example both the level and type of effort required to use EPICS with other control system components as well as the benefits that may arise.

  11. An integrated one-step system to extract, analyze and annotate all relevant information from image-based cell screening of chemical libraries.

    Science.gov (United States)

    Rabal, Obdulia; Link, Wolfgang; Serelde, Beatriz G; Bischoff, James R; Oyarzabal, Julen

    2010-04-01

    Here we report the development and validation of a complete solution to manage and analyze the data produced by image-based phenotypic screening campaigns of small-molecule libraries. In one step initial crude images are analyzed for multiple cytological features, statistical analysis is performed and molecules that produce the desired phenotypic profile are identified. A naïve Bayes classifier, integrating chemical and phenotypic spaces, is built and utilized during the process to assess those images initially classified as "fuzzy"-an automated iterative feedback tuning. Simultaneously, all this information is directly annotated in a relational database containing the chemical data. This novel fully automated method was validated by conducting a re-analysis of results from a high-content screening campaign involving 33 992 molecules used to identify inhibitors of the PI3K/Akt signaling pathway. Ninety-two percent of confirmed hits identified by the conventional multistep analysis method were identified using this integrated one-step system as well as 40 new hits, 14.9% of the total, originally false negatives. Ninety-six percent of true negatives were properly recognized too. A web-based access to the database, with customizable data retrieval and visualization tools, facilitates the posterior analysis of annotated cytological features which allows identification of additional phenotypic profiles; thus, further analysis of original crude images is not required.

  12. Integrative Genomics and Computational Systems Medicine

    Energy Technology Data Exchange (ETDEWEB)

    McDermott, Jason E.; Huang, Yufei; Zhang, Bing; Xu, Hua; Zhao, Zhongming

    2014-01-01

    The exponential growth in generation of large amounts of genomic data from biological samples has driven the emerging field of systems medicine. This field is promising because it improves our understanding of disease processes at the systems level. However, the field is still in its young stage. There exists a great need for novel computational methods and approaches to effectively utilize and integrate various omics data.

  13. Integration of energy systems in the small-capacity range

    Energy Technology Data Exchange (ETDEWEB)

    Siddhartha Bhatt, M.; Mandi, R.P.; Nanda Kumar, V.N. [Energy Research Centre, Trivandrum (India). Central Power Research Inst.

    1998-05-01

    Studies on integration of energy supply and utilization systems are reported. Purely thermal systems (heating and cooling and heating-only systems), thermomechanical systems (combined heat and power), and purely mechanical systems (integrated energy delivery systems) are discussed. It is concluded that there is a broad scope for optimization of integrated supply systems.

  14. An integrated scheduling and program management system

    Science.gov (United States)

    Porter, D.; Gibson, J. D.; Williams, G. G.

    2012-09-01

    An integrated scheduling and program management system is being developed for the MMT Observatory (MMTO), Arizona, USA. A systems engineering approach is used to combine existing and new relational databases, spreadsheets, file storage systems, and web-based user interfaces into a single unified system. An overview of software design, data management, user interfaces, and techniques for performance assessment is presented. Goals of this system include streamlined data management and an optimized user experience. The MMTO has over a dozen different telescope configurations, including three secondary mirrors and a wide range of observing instruments. Scheduling is complex for the varying telescope configurations, limited available observing time, and appropriate astronomic conditions (e.g., lunar phase) for each science project. Scheduled telescope configurations can be used to perform safety checks of actual configuration during telescope operations. Programmatic information is automatically input into nightly telescope operator (TO) logs by the system. The TO's provide additional information into the system on telescope usage, observing conditions (e.g., weather conditions), and observatory closure (e.g., from instrument malfunction or inclement weather). All of this information is synthesized to assess telescope and observatory performance. Web interfaces to the system can be used by observers to submit information, such as travel plans, instrumentation requirements, and observing catalogs. A service request (SR) (i.e., trouble report) system has also been developed for tracking operational issues. The specific needs of the MMTO have been met through in-house software development of this integrated scheduling and program management system.

  15. Integrating the Unmanned Aircraft System into the National Airspace System

    Science.gov (United States)

    2011-06-18

    and the ground control system. The ground control system is comprised of several integrated components to include: avionics , fuel, navigation...accessed January 15, 2011). U.S. Army Unmanned Aircraft Systems Roadmap 2010-2035: Eyes of the Army. Fort Rucker, Ala .: U.S. Army Unmanned Aircraft

  16. 46 CFR 111.105-5 - System integrity.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false System integrity. 111.105-5 Section 111.105-5 Shipping... REQUIREMENTS Hazardous Locations § 111.105-5 System integrity. In order to maintain system integrity, each....10-1), but not in combination in a manner that will compromise system integrity or safety. Hazardous...

  17. Integrated Information System for Higher Education Qualifications

    Directory of Open Access Journals (Sweden)

    Catalin Ionut SILVESTRU

    2012-10-01

    Full Text Available In the present article we aim to study thoroughly and detail aspects related to architectures specific for e-learning and management of human resources training interconnected to management of qualifications. In addition, we take into consideration combining e-learning architectures with software in an e-learning system interconnected with the National Registry of Qualifications of Higher Education, in view of developing and information system that correlates educational supply from higher education from Romania with labor market demands through qualifications. The scientific endeavor consists of original architectural solutions to integrate data, systems, processes, services from various sources and to use them in the proposed system. The practical result of the scientific endeavor is represented by design of architectures required for developing an e-learning system interconnected with the National Registry of Qualifications from Romania, which involve in first stage the qualifications provided by higher education. The proposed innovative solution consists in the fact that the proposed information system combines the advantages of content management system (CMS with learning content management system (LCMS and with reusable learning objects (RLO. Thus, the architecture proposed in the research ensures the integration of a content management system with a portal for information, guidance and support in making a professional project. The integration enables correlation of competences with content areas and specific items from various teaching subjects, thus evaluating the usefulness for this registry from learning/educational perspective. Using the proposed information system in enables correlation among qualifications, content of educational program and continuous self-evaluation opportunities, which facilitate monitoring of progress and adjustment of learning content.

  18. Turnkey CAD/CAM systems' integration with IPAD systems

    Science.gov (United States)

    Blauth, R. E.

    1980-01-01

    Today's commercially available turnkey CAD/CAM systems provide a highly interactive environment, and support many specialized application functions for the design/drafting/manufacturing process. This paper presents an overview of several aerospace companies which have successfully integrated turnkey CAD/CAM systems with their own company wide engineering and manufacturing systems. It also includes a vendor's view of the benefits as well as the disadvantages of such integration efforts. Specific emphasis is placed upon the selection of standards for representing geometric engineering data and for communicating such information between different CAD/CAM systems.

  19. Ultra Small Integrated Optical Fiber Sensing System

    Directory of Open Access Journals (Sweden)

    Peter Van Daele

    2012-09-01

    Full Text Available This paper introduces a revolutionary way to interrogate optical fiber sensors based on fiber Bragg gratings (FBGs and to integrate the necessary driving optoelectronic components with the sensor elements. Low-cost optoelectronic chips are used to interrogate the optical fibers, creating a portable dynamic sensing system as an alternative for the traditionally bulky and expensive fiber sensor interrogation units. The possibility to embed these laser and detector chips is demonstrated resulting in an ultra thin flexible optoelectronic package of only 40 μm, provided with an integrated planar fiber pigtail. The result is a fully embedded flexible sensing system with a thickness of only 1 mm, based on a single Vertical-Cavity Surface-Emitting Laser (VCSEL, fiber sensor and photodetector chip. Temperature, strain and electrodynamic shaking tests have been performed on our system, not limited to static read-out measurements but dynamically reconstructing full spectral information datasets.

  20. Integrated computer-aided retinal photocoagulation system

    Science.gov (United States)

    Barrett, Steven F.; Wright, Cameron H. G.; Oberg, Erik D.; Rockwell, Benjamin A.; Cain, Clarence P.; Jerath, Maya R.; Rylander, Henry G., III; Welch, Ashley J.

    1996-05-01

    Successful retinal tracking subsystem testing results in vivo on rhesus monkeys using an argon continuous wave laser and an ultra-short pulse laser are presented. Progress on developing an integrated robotic retinal laser surgery system is also presented. Several interesting areas of study have developed: (1) 'doughnut' shaped lesions that occur under certain combinations of laser power, spot size, and irradiation time complicating measurements of central lesion reflectance, (2) the optimal retinal field of view to achieve simultaneous tracking and lesion parameter control, and (3) a fully digital versus a hybrid analog/digital tracker using confocal reflectometry integrated system implementation. These areas are investigated in detail in this paper. The hybrid system warrants a separate presentation and appears in another paper at this conference.

  1. Integrated system for automated financial document processing

    Science.gov (United States)

    Hassanein, Khaled S.; Wesolkowski, Slawo; Higgins, Ray; Crabtree, Ralph; Peng, Antai

    1997-02-01

    A system was developed that integrates intelligent document analysis with multiple character/numeral recognition engines in order to achieve high accuracy automated financial document processing. In this system, images are accepted in both their grayscale and binary formats. A document analysis module starts by extracting essential features from the document to help identify its type (e.g. personal check, business check, etc.). These features are also utilized to conduct a full analysis of the image to determine the location of interesting zones such as the courtesy amount and the legal amount. These fields are then made available to several recognition knowledge sources such as courtesy amount recognition engines and legal amount recognition engines through a blackboard architecture. This architecture allows all the available knowledge sources to contribute incrementally and opportunistically to the solution of the given recognition query. Performance results on a test set of machine printed business checks using the integrated system are also reported.

  2. Integrated safety management system verification: Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    Christensen, R.F.

    1998-08-10

    Department of Energy (DOE) Policy (P) 450.4, Safety Management System Policy, commits to institutionalization of an Integrated Safety Management System (ISMS) throughout the DOE complex. The DOE Acquisition Regulations (DEAR, 48 CFR 970) requires contractors to manage and perform work in accordance with a documented Integrated Safety Management System (ISMS). Guidance and expectations have been provided to PNNL by incorporation into the operating contract (Contract DE-ACM-76FL0 1830) and by letter. The contract requires that the contractor submit a description of their ISMS for approval by DOE. PNNL submitted their proposed Safety Management System Description for approval on November 25,1997. RL tentatively approved acceptance of the description pursuant to a favorable recommendation from this review. The Integrated Safety Management System Verification is a review of the adequacy of the ISMS description in fulfilling the requirements of the DEAR and the DOE Policy. The purpose of this review is to provide the Richland Operations Office Manager with a recommendation for approval of the ISMS description of the Pacific Northwest Laboratory based upon compliance with the requirements of 49 CFR 970.5204(-2 and -78); and to verify the extent and maturity of ISMS implementation within the Laboratory. Further the review will provide a model for other DOE laboratories managed by the Office of Assistant Secretary for Energy Research.

  3. Y-12 Integrated Materials Management System

    Energy Technology Data Exchange (ETDEWEB)

    Alspaugh, D. H.; Hickerson, T. W.

    2002-06-03

    The Integrated Materials Management System, when fully implemented, will provide the Y-12 National Security Complex with advanced inventory information and analysis capabilities and enable effective assessment, forecasting and management of nuclear materials, critical non-nuclear materials, and certified supplies. These capabilities will facilitate future Y-12 stockpile management work, enhance interfaces to existing National Nuclear Security Administration (NNSA) corporate-level information systems, and enable interfaces to planned NNSA systems. In the current national nuclear defense environment where, for example, weapons testing is not permitted, material managers need better, faster, more complete information about material properties and characteristics. They now must manage non-special nuclear material at the same high-level they have managed SNM, and information capabilities about both must be improved. The full automation and integration of business activities related to nuclear and non-nuclear materials that will be put into effect by the Integrated Materials Management System (IMMS) will significantly improve and streamline the process of providing vital information to Y-12 and NNSA managers. This overview looks at the kinds of information improvements targeted by the IMMS project, related issues, the proposed information architecture, and the progress to date in implementing the system.

  4. Digital cell counting device integrated with a single-cell array.

    Science.gov (United States)

    Saeki, Tatsuya; Hosokawa, Masahito; Lim, Tae-kyu; Harada, Manabu; Matsunaga, Tadashi; Tanaka, Tsuyoshi

    2014-01-01

    In this paper, we present a novel cell counting method accomplished using a single-cell array fabricated on an image sensor, complementary metal oxide semiconductor sensor. The single-cell array was constructed using a microcavity array, which can trap up to 7,500 single cells on microcavities periodically arranged on a plane metallic substrate via the application of a negative pressure. The proposed method for cell counting is based on shadow imaging, which uses a light diffraction pattern generated by the microcavity array and trapped cells. Under illumination, the cell-occupied microcavities are visualized as shadow patterns in an image recorded by the complementary metal oxide semiconductor sensor due to light attenuation. The cell count is determined by enumerating the uniform shadow patterns created from one-on-one relationships with single cells trapped on the microcavities in digital format. In the experiment, all cell counting processes including entrapment of non-labeled HeLa cells from suspensions on the array and image acquisition of a wide-field-of-view of 30 mm(2) in 1/60 seconds were implemented in a single integrated device. As a result, the results from the digital cell counting had a linear relationship with those obtained from microscopic observation (r(2)  = 0.99). This platform could be used at extremely low cell concentrations, i.e., 25-15,000 cells/mL. Our proposed system provides a simple and rapid miniaturized cell counting device for routine laboratory use.

  5. An integration system for investment An integration system for investment turbine blade

    Directory of Open Access Journals (Sweden)

    Jiang Ruisong

    2008-05-01

    Full Text Available An integration system was developed to satisfy the need of information integration in the process of designing, investment casting and monitoring aero-engine’s turbo blade. The general architecture is detailed presented in this paper. The system mainly comprises of product master model, design information management, anti-deformation design of mould cavity, intelligence mould design and blade testing. The developed system can manage mould design and blade test data fl ow, optimize mould design process and achieve the goal of integration design.

  6. Quantum integrable systems. Quantitative methods in biology

    CERN Document Server

    Feverati, Giovanni

    2011-01-01

    Quantum integrable systems have very strong mathematical properties that allow an exact description of their energetic spectrum. From the Bethe equations, I formulate the Baxter "T-Q" relation, that is the starting point of two complementary approaches based on nonlinear integral equations. The first one is known as thermodynamic Bethe ansatz, the second one as Kl\\"umper-Batchelor-Pearce-Destri- de Vega. I show the steps toward the derivation of the equations for some of the models concerned. I study the infrared and ultraviolet limits and discuss the numerical approach. Higher rank integrals of motion can be obtained, so gaining some control on the eigenvectors. After, I discuss the Hubbard model in relation to the N = 4 supersymmetric gauge theory. The Hubbard model describes hopping electrons on a lattice. In the second part, I present an evolutionary model based on Turing machines. The goal is to describe aspects of the real biological evolution, or Darwinism, by letting evolve populations of algorithms. ...

  7. Product-Oriented Integrated CAPP System

    Institute of Scientific and Technical Information of China (English)

    王凤岐; 王磊; 郭伟; 白峰

    2003-01-01

    The necessity of product-oriented integrated computer aided process planning (CAPP) is analyzed,and the system architecture and the main functions are described in detail. The key issues of the system, such as the product-oriented process planning method, the human-machine cooperation in process planning, the generation of manufacture bill of material (MBOM) and the dynamic data exchanging technology between CAPP and enterprise resource planning (ERP), are discussed. The CAPP system has been applied at a CIMS environment corporation successfully.

  8. Data readout system utilizing photonic integrated circuit

    Energy Technology Data Exchange (ETDEWEB)

    Stopiński, S., E-mail: S.Stopinski@tue.nl [COBRA Research Institute, Eindhoven University of Technology (Netherlands); Institute of Microelectronics and Optoelectronics, Warsaw University of Technology (Poland); Malinowski, M.; Piramidowicz, R. [Institute of Microelectronics and Optoelectronics, Warsaw University of Technology (Poland); Smit, M.K.; Leijtens, X.J.M. [COBRA Research Institute, Eindhoven University of Technology (Netherlands)

    2013-10-11

    We describe a novel optical solution for data readout systems. The core of the system is an Indium-Phosphide photonic integrated circuit performing as a front-end readout unit. It functions as an optical serializer in which the serialization of the input signal is provided by means of on-chip optical delay lines. The circuit employs electro-optic phase shifters to build amplitude modulators, power splitters for signal distribution, semiconductor optical amplifiers for signal amplification as well as on-chip reflectors. We present the concept of the system, the design and first characterization results of the devices that were fabricated in a multi-project wafer run.

  9. Video signals integrator (VSI) system architecture

    Science.gov (United States)

    Kasprowicz, Grzegorz; Pastuszak, Grzegorz; Poźniak, Krzysztof; Trochimiuk, Maciej; Abramowski, Andrzej; Gaska, Michal; Bukowiecka, Danuta; Tyburska, Agata; Struniawski, Jarosław; Jastrzebski, Pawel; Jewartowski, Blazej; Frasunek, Przemysław; Nalbach-Moszynska, Małgorzata; Brawata, Sebastian; Bubak, Iwona; Gloza, Małgorzata

    2016-09-01

    The purpose of the project is development of a platform which integrates video signals from many sources. The signals can be sourced by existing analogue CCTV surveillance installations, recent internet-protocol (IP) cameras or single cameras of any type. The system will consist of portable devices that provide conversion, encoding, transmission and archiving. The sharing subsystem will use distributed file system and also user console which provides simultaneous access to any of video streams in real time. The system is fully modular so its extension is possible, both from hardware and software side. Due to standard modular technology used, partial technology modernization is also possible during a long exploitation period.

  10. Nonabelian Integrable Systems, Quasideterminants, and Marchenko Lemma

    CERN Document Server

    Etingof, P; Retakh, V S; Etingof, Pavel; Gelfand, Israel; Retakh, Vladimir

    1997-01-01

    We find explicit (multisoliton) solutions for nonabelian integrable systems such as periodic Toda field equations, Langmuir equations, and Schrodinger equations for functions with values in any associative algebra. The solution for nonabelian Toda field equations for root systems of types A, B, C was expressed by the authors in a previous paper (q-alg/9701008) using quasideterminants introduced by the last two authors. To find multisoliton solutions of periodic Toda equations and other nonabelian systems we use a combination of these ideas with important lemmas which are due to Marchenko.

  11. Implementation of Data Integration using Distributed Systems: A Review

    OpenAIRE

    Rakesh Jaitly

    2011-01-01

    Data integration in the distributed data system is introduced to solve the problem that data model has. The data integration in the distributional systems can be supported effectively. Data conversion is still a challenge in distributed system integration.Community based system is used for distributed data integration. It comprises of three elements: community, data model and communication protocol. The integration system solves the data heterogeneous problem in production management, making ...

  12. Integrated safety management system verification: Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Christensen, R.F.

    1998-08-12

    Department of Energy (DOE) Policy (P) 450.4, Safety Management System Policy, commits to institutionalizing an Integrated Safety Management System (ISMS) throughout the DOE complex. The DOE Acquisition Regulations (DEAR 48 CFR 970) requires contractors to manage and perform work in accordance with a documented Integrated Safety Management System. The Manager, Richland Operations Office (RL), initiated a combined Phase 1 and Phase 2 Integrated Safety Management Verification review to confirm that PNNL had successfully submitted a description of their ISMS and had implemented ISMS within the laboratory facilities and processes. A combined review was directed by the Manager, RL, based upon the progress PNNL had made in the implementation of ISM. This report documents the results of the review conducted to verify: (1) that the PNNL integrated safety management system description and enabling documents and processes conform to the guidance provided by the Manager, RL; (2) that corporate policy is implemented by line managers; (3) that PNNL has provided tailored direction to the facility management; and (4) the Manager, RL, has documented processes that integrate their safety activities and oversight with those of PNNL. The general conduct of the review was consistent with the direction provided by the Under Secretary`s Draft Safety Management System Review and Approval Protocol. The purpose of this review was to provide the Manager, RL, with a recommendation to the adequacy of the ISMS description of the Pacific Northwest Laboratory based upon compliance with the requirements of 49 CFR 970.5204(-2 and -78); and, to provide an evaluation of the extent and maturity of ISMS implementation within the Laboratory. Further, this review was intended to provide a model for other DOE Laboratories. In an effort to reduce the time and travel costs associated with ISM verification the team agreed to conduct preliminary training and orientation electronically and by phone. These

  13. Integrated safety management system verification: Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Christensen, R.F.

    1998-08-12

    Department of Energy (DOE) Policy (P) 450.4, Safety Management System Policy, commits to institutionalizing an Integrated Safety Management System (ISMS) throughout the DOE complex. The DOE Acquisition Regulations (DEAR 48 CFR 970) requires contractors to manage and perform work in accordance with a documented Integrated Safety Management System. The Manager, Richland Operations Office (RL), initiated a combined Phase 1 and Phase 2 Integrated Safety Management Verification review to confirm that PNNL had successfully submitted a description of their ISMS and had implemented ISMS within the laboratory facilities and processes. A combined review was directed by the Manager, RL, based upon the progress PNNL had made in the implementation of ISM. This report documents the results of the review conducted to verify: (1) that the PNNL integrated safety management system description and enabling documents and processes conform to the guidance provided by the Manager, RL; (2) that corporate policy is implemented by line managers; (3) that PNNL has provided tailored direction to the facility management; and (4) the Manager, RL, has documented processes that integrate their safety activities and oversight with those of PNNL. The general conduct of the review was consistent with the direction provided by the Under Secretary`s Draft Safety Management System Review and Approval Protocol. The purpose of this review was to provide the Manager, RL, with a recommendation to the adequacy of the ISMS description of the Pacific Northwest Laboratory based upon compliance with the requirements of 49 CFR 970.5204(-2 and -78); and, to provide an evaluation of the extent and maturity of ISMS implementation within the Laboratory. Further, this review was intended to provide a model for other DOE Laboratories. In an effort to reduce the time and travel costs associated with ISM verification the team agreed to conduct preliminary training and orientation electronically and by phone. These

  14. Modeling of a thermally integrated 10 kWe planar solid oxide fuel cell system with anode offgas recycling and internal reforming by discretization in flow direction

    Science.gov (United States)

    Wahl, Stefanie; Segarra, Ana Gallet; Horstmann, Peter; Carré, Maxime; Bessler, Wolfgang G.; Lapicque, François; Friedrich, K. Andreas

    2015-04-01

    Combined heat and power production (CHP) based on solid oxide fuel cells (SOFC) is a very promising technology to achieve high electrical efficiency to cover power demand by decentralized production. This paper presents a dynamic quasi 2D model of an SOFC system which consists of stack and balance of plant and includes thermal coupling between the single components. The model is implemented in Modelica® and validated with experimental data for the stack UI-characteristic and the thermal behavior. The good agreement between experimental and simulation results demonstrates the validity of the model. Different operating conditions and system configurations are tested, increasing the net electrical efficiency to 57% by implementing an anode offgas recycle rate of 65%. A sensitivity analysis of characteristic values of the system like fuel utilization, oxygen-to-carbon ratio and electrical efficiency for different natural gas compositions is carried out. The result shows that a control strategy adapted to variable natural gas composition and its energy content should be developed in order to optimize the operation of the system.

  15. Analysis and prediction of pathways in HeLa cells by integrating biological levels of organization with systems-biology approaches.

    Directory of Open Access Journals (Sweden)

    Juan Carlos Higareda-Almaraz

    Full Text Available It has recently begun to be considered that cancer is a systemic disease and that it must be studied at every level of complexity using many of the currently available approaches, including high-throughput technologies and bioinformatics. To achieve such understanding in cervical cancer, we collected information on gene, protein and phosphoprotein expression of the HeLa cell line and performed a comprehensive analysis of the different signaling pathways, transcription networks and metabolic events in which they participate. A total expression analysis by RNA-Seq of the HeLa cell line showed that 19,974 genes were transcribed. Of these, 3,360 were over-expressed, and 2,129 under-expressed when compared to the NHEK cell line. A protein-protein interaction network was derived from the over-expressed genes and used to identify central elements and, together with the analysis of over-represented transcription factor motifs, to predict active signaling and regulatory pathways. This was further validated by Metal-Oxide Affinity Chromatography (MOAC and Tandem Mass Spectrometry (MS/MS assays which retrieved phosphorylated proteins. The 14-3-3 family members emerge as important regulators in carcinogenesis and as possible clinical targets. We observed that the different over- and under-regulated pathways in cervical cancer could be interrelated through elements that participate in crosstalks, therefore belong to what we term "meta-pathways". Additionally, we highlighted the relations of each one of the differentially represented pathways to one or more of the ten hallmarks of cancer. These features could be maintained in many other types of cancer, regardless of mutations or genomic rearrangements, and favor their robustness, adaptations and the evasion of tissue control. Probably, this could explain why cancer cells are not eliminated by selective pressure and why therapy trials directed against molecular targets are not as effective as expected.

  16. An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma.

    Science.gov (United States)

    Hakimi, A Ari; Reznik, Ed; Lee, Chung-Han; Creighton, Chad J; Brannon, A Rose; Luna, Augustin; Aksoy, B Arman; Liu, Eric Minwei; Shen, Ronglai; Lee, William; Chen, Yang; Stirdivant, Steve M; Russo, Paul; Chen, Ying Bei; Tickoo, Satish K; Reuter, Victor E; Cheng, Emily H; Sander, Chris; Hsieh, James J

    2016-01-11

    Dysregulated metabolism is a hallmark of cancer, manifested through alterations in metabolites. We performed metabolomic profiling on 138 matched clear cell renal cell carcinoma (ccRCC)/normal tissue pairs and found that ccRCC is characterized by broad shifts in central carbon metabolism, one-carbon metabolism, and antioxidant response. Tumor progression and metastasis were associated with metabolite increases in glutathione and cysteine/methionine metabolism pathways. We develop an analytic pipeline and visualization tool (metabolograms) to bridge the gap between TCGA transcriptomic profiling and our metabolomic data, which enables us to assemble an integrated pathway-level metabolic atlas and to demonstrate discordance between transcriptome and metabolome. Lastly, expression profiling was performed on a high-glutathione cluster, which corresponds to a poor-survival subgroup in the ccRCC TCGA cohort. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. An integrated system for pipeline condition monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Strong, Andrew P.; Lees, Gareth; Hartog, Arthur; Twohig, Richard; Kader, Kamal; Hilton, Graeme; Mullens, Stephen; Khlybov, Artem [Schlumberger, Southampton (United Kingdom); Sanderson, Norman [BP Exploration, Sunbury (United Kingdom)

    2009-07-01

    In this paper we present the unique and innovative 'Integriti' pipeline and flow line integrity monitoring system developed by Schlumberger in collaboration with BP. The system uses optical fiber distributed sensors to provide simultaneous distributed measurements of temperature, strain and vibration for the detection, monitoring, and location of events including: Third Party Interference (TPI), including multiple simultaneous disturbances; geo-hazards and landslides; gas and oil leaks; permafrost protection. The Integriti technology also provides a unique means for tracking the progress of cleaning and instrumented pigs using existing optical telecom and data communications cables buried close to pipelines. The Integriti solution provides a unique and proactive approach to pipeline integrity management. It performs analysis of a combination of measurands to provide the pipeline operator with an event recognition and location capability, in effect providing a hazard warning system, and offering the operator the potential to take early action to prevent loss. Through the use of remote, optically powered amplification, an unprecedented detection range of 100 km is possible without the need for any electronics and therefore remote power in the field. A system can thus monitor 200 km of pipeline when configured to monitor 100 km upstream and downstream from a single location. As well as detecting conditions and events leading to leaks, this fully integrated system provides a means of detecting and locating small leaks in gas pipelines below the threshold of present online leak detection systems based on monitoring flow parameters. Other significant benefits include: potential reductions in construction costs; enhancement of the operator's existing integrity management program; potential reductions in surveillance costs and HSE risks. In addition to onshore pipeline systems this combination of functionality and range is available for practicable

  18. Path integrals for dimerized quantum spin systems

    Energy Technology Data Exchange (ETDEWEB)

    Foussats, Adriana, E-mail: afoussats@gmail.co [Facultad de Ciencias Exactas, Ingenieria y Agrimensura and Instituto de Fisica Rosario (UNR-CONICET), Av. Pellegrini 250, 2000 Rosario (Argentina); Greco, Andres [Facultad de Ciencias Exactas, Ingenieria y Agrimensura and Instituto de Fisica Rosario (UNR-CONICET), Av. Pellegrini 250, 2000 Rosario (Argentina); Muramatsu, Alejandro [Institut fuer Theoretische Physik III, Universitaet Stuttgart, Pfaffenwaldring 57, D-70550 Stuttgart (Germany)

    2011-01-11

    Dimerized quantum spin systems may appear under several circumstances, e.g. by a modulation of the antiferromagnetic exchange coupling in space, or in frustrated quantum antiferromagnets. In general, such systems display a quantum phase transition to a Neel state as a function of a suitable coupling constant. We present here two path-integral formulations appropriate for spin S=1/2 dimerized systems. The first one deals with a description of the dimers degrees of freedom in an SO(4) manifold, while the second one provides a path-integral for the bond-operators introduced by Sachdev and Bhatt. The path-integral quantization is performed using the Faddeev-Jackiw symplectic formalism for constrained systems, such that the measures and constraints that result from the algebra of the operators is provided in both cases. As an example we consider a spin-Peierls chain, and show how to arrive at the corresponding field-theory, starting with both an SO(4) formulation and bond-operators.

  19. Integrated monitoring and surveillance system demonstration project

    Energy Technology Data Exchange (ETDEWEB)

    Aumeier, S.E.; Walters, G. [Argonne National Lab., Idaho Falls, ID (United States); Kotter, D.; Walrath, W.M.; Zamecnik, R.J. [Lockheed-Martin Idaho Technologies Company, Idaho Falls, ID (United States)

    1997-07-01

    We present a summary of efforts associated with the installation of an integrated system for the surveillance and monitoring of stabilized plutonium metals and oxides in long-term storage. The product of this effort will include a Pu storage requirements document, baseline integrated monitoring and surveillance system (IMSS) prototype and test bed that will be installed in the Fuel Manufacturing Facility (FMF) nuclear material vault at Argonne National Laboratory - West (ANL-W), and a Pu tracking database including data analysis capabilities. The prototype will be based on a minimal set of vault and package monitoring requirements as derived from applicable DOE documentation and guidelines, detailed in the requirements document, including DOE-STD-3013-96. The use of standardized requirements will aid individual sites in the selection of sensors that best suit their needs while the prototype IMSS, located at ANL-W, will be used as a test bed to compare and contrast sensor performance against a baseline integrated system (the IMSS), demonstrate system capabilities, evaluate potential technology gaps, and test new hardware and software designs using various storage configurations. With efforts currently underway to repackage and store a substantial quantity of plutonium and plutonium-bearing material within the DOE complex, this is an opportune time to undertake such a project. 4 refs.

  20. Diablo Canyon plant information management system and integrated communication system

    Energy Technology Data Exchange (ETDEWEB)

    Stanley, J.W.; Groff, C.

    1990-06-01

    The implementation of a comprehensive maintenance system called the plant information management system (PIMS) at the Diablo Canyon plant, together with its associated integrated communication system (ICS), is widely regarded as the most comprehensive undertaking of its kind in the nuclear industry. This paper provides an overview of the program at Diablo Canyon, an evaluation of system benefits, and highlights the future course of PIMS.

  1. Information survey for microcomputer systems integration

    Energy Technology Data Exchange (ETDEWEB)

    Hake, K.A.

    1991-12-01

    One goal of the PM-AIM is to provide US Army Project Managers (PMs) and Project Executive Officers (PEOs) with a fundamental microcomputing resource to help perform acquisition information management and its concomitant reporting requirements. Providing key application software represents one means of accomplishing this goal. This workstation would furnish a broad range of capabilities needed in the PM and PEO office settings as well as software tools for specific project management and acquisition information. Although still in the conceptual phase, the practical result of this exercise in systems integration will likely be a system called the Project Manager`s Information System (PMIS) or the AIM workstation. It would include such software as, Project Manager`s System Software (PMSS), Defense Acquisition Executive Summary (DAES), and Consolidated Acquisition Reporting System (CARS) and would conform to open systems architecture as accepted by the Department of Defense. ORNL has assisted PM-AIM in the development of technology ideas for the PMIS workstation concept. This paper represents the compilation of information gained during this process. This information is presented as a body of knowledge (or knowledge domain) defining the complex technology of microcomputing. The concept of systems integration or tying together all hardware and software components reflects the nature of PM-AIM`s task in attempting to field a PMIS or AIM workstation.

  2. Information survey for microcomputer systems integration

    Energy Technology Data Exchange (ETDEWEB)

    Hake, K.A.

    1991-12-01

    One goal of the PM-AIM is to provide US Army Project Managers (PMs) and Project Executive Officers (PEOs) with a fundamental microcomputing resource to help perform acquisition information management and its concomitant reporting requirements. Providing key application software represents one means of accomplishing this goal. This workstation would furnish a broad range of capabilities needed in the PM and PEO office settings as well as software tools for specific project management and acquisition information. Although still in the conceptual phase, the practical result of this exercise in systems integration will likely be a system called the Project Manager's Information System (PMIS) or the AIM workstation. It would include such software as, Project Manager's System Software (PMSS), Defense Acquisition Executive Summary (DAES), and Consolidated Acquisition Reporting System (CARS) and would conform to open systems architecture as accepted by the Department of Defense. ORNL has assisted PM-AIM in the development of technology ideas for the PMIS workstation concept. This paper represents the compilation of information gained during this process. This information is presented as a body of knowledge (or knowledge domain) defining the complex technology of microcomputing. The concept of systems integration or tying together all hardware and software components reflects the nature of PM-AIM's task in attempting to field a PMIS or AIM workstation.

  3. MAVIS: An integrated system for live microscopy and vitrification

    Energy Technology Data Exchange (ETDEWEB)

    Koning, Roman I., E-mail: r.i.koning@lumc.nl [Department of Molecular Cell Biology, Albinusdreef 2, P.O. Box 9600, 2300 RC, Leiden University Medical Center, Leiden (Netherlands); Faas, Frank G. [Department of Molecular Cell Biology, Albinusdreef 2, P.O. Box 9600, 2300 RC, Leiden University Medical Center, Leiden (Netherlands); Boonekamp, Michael; Visser, Bram de; Janse, Jan [Department of Instrumental Development, Albinusdreef 2, P.O. Box 9600, 2300 RC, Leiden University Medical Center, Leiden (Netherlands); Wiegant, Joop C. [Department of Molecular Cell Biology, Albinusdreef 2, P.O. Box 9600, 2300 RC, Leiden University Medical Center, Leiden (Netherlands); Breij, Anna de [Department of Infectious Diseases, Albinusdreef 2, P.O. Box 9600, 2300 RC, Leiden University Medical Center, Leiden (Netherlands); Willemse, Joost [Department of Molecular Cell Biology, Albinusdreef 2, P.O. Box 9600, 2300 RC, Leiden University Medical Center, Leiden (Netherlands); Nibbering, Peter H. [Department of Infectious Diseases, Albinusdreef 2, P.O. Box 9600, 2300 RC, Leiden University Medical Center, Leiden (Netherlands); Tanke, Hans J.; Koster, Abraham J. [Department of Molecular Cell Biology, Albinusdreef 2, P.O. Box 9600, 2300 RC, Leiden University Medical Center, Leiden (Netherlands)

    2014-08-01

    Cryo-electron microscopy of vitrified biological samples can provide three-dimensional reconstructions of macromolecules and organelles within bacteria and cells at nanometer scale resolution, even in native conditions. Localization of specific structures and imaging of cellular dynamics in cellular cryo-electron microscopy is limited by (i) the use of cryo-fixation to preserve cellular structures, (ii) the restricted availability of electron dense markers to label molecules inside cells and (iii) the inherent low contrast of cryo electron microscopy. These limitations can be mitigated to a large extend by correlative light and electron microscopy, where the sample is imaged by both light and electron microscopy. Here we present a Microscopy and Vitrification Integrated System (MAVIS) that combines a light microscope with a plunger to vitrify thin specimens. MAVIS provides the capability for fluorescence light microscopic imaging of living cells and bacteria that are adhered to an electron microscopy grid and subsequent vitrification within a time frame of seconds. The instrument allows targeting of dynamic biological events in time and space by fluorescence microscopy for subsequent cryo light and electron microscopy. Here we describe the design and performance of the MAVIS, illustrated with biological examples. - Highlights: • We developed new plunger: a Microscopy and Vitrification Integrated System (MAVIS). • The MAVIS is a new tool for integrating of live microscopy and vitrification. • The MAVIS allows fluorescence LM of living cells and vitrification within seconds. • Here we describe the MAVIS design and performance, and show biological examples.

  4. Development of Human System Integration at NASA

    Science.gov (United States)

    Whitmore, Mihriban; McGuire, Kerry; Thompson, Shelby; Vos, Gordon

    2012-01-01

    Human Systems Integration seeks to design systems around the capabilities and limitations of the humans which use and interact with the system, ensuring greater efficiency of use, reduced error rates, and less rework in the design, manufacturing and operational deployment of hardware and software. One of the primary goals of HSI is to get the human factors practitioner involved early in the design process. In doing so, the aim is to reduce future budget costs and resources in redesign and training. By the preliminary design phase of a project nearly 80% of the total cost of the project is locked in. Potential design changes recommended by evaluations past this point will have little effect due to lack of funding or a huge cost in terms of resources to make changes. Three key concepts define an effective HSI program. First, systems are comprised of hardware, software, and the human, all of which operate within an environment. Too often, engineers and developers fail to consider the human capacity or requirements as part of the system. This leads to poor task allocation within the system. To promote ideal task allocation, it is critical that the human element be considered early in system development. Poor design, or designs that do not adequately consider the human component, could negatively affect physical or mental performance, as well as, social behavior. Second, successful HSI depends upon integration and collaboration of all the domains that represent acquisition efforts. Too often, these domains exist as independent disciplines due to the location of expertise within the service structure. Proper implementation of HSI through participation would help to integrate these domains and disciplines to leverage and apply their interdependencies to attain an optimal design. Via this process domain interests can be integrated to perform effective HSI through trade-offs and collaboration. This provides a common basis upon which to make knowledgeable decisions. Finally

  5. Fostering synergy between cell biology and systems biology

    OpenAIRE

    2015-01-01

    In the shared pursuit of elucidating detailed mechanisms of cell function, systems biology presents a natural complement to ongoing efforts in cell biology. Systems biology aims to characterize biological systems through integrated and quantitative modeling of cellular information. The process of model building and analysis provides value through synthesizing and cataloging information about cells and molecules; predicting mechanisms and identifying generalizable themes; generating hypotheses...

  6. Integrated Reliability and Risk Analysis System (IRRAS)

    Energy Technology Data Exchange (ETDEWEB)

    Russell, K D; McKay, M K; Sattison, M.B. Skinner, N.L.; Wood, S T [EG and G Idaho, Inc., Idaho Falls, ID (United States); Rasmuson, D M [Nuclear Regulatory Commission, Washington, DC (United States)

    1992-01-01

    The Integrated Reliability and Risk Analysis System (IRRAS) is a state-of-the-art, microcomputer-based probabilistic risk assessment (PRA) model development and analysis tool to address key nuclear plant safety issues. IRRAS is an integrated software tool that gives the user the ability to create and analyze fault trees and accident sequences using a microcomputer. This program provides functions that range from graphical fault tree construction to cut set generation and quantification. Version 1.0 of the IRRAS program was released in February of 1987. Since that time, many user comments and enhancements have been incorporated into the program providing a much more powerful and user-friendly system. This version has been designated IRRAS 4.0 and is the subject of this Reference Manual. Version 4.0 of IRRAS provides the same capabilities as Version 1.0 and adds a relational data base facility for managing the data, improved functionality, and improved algorithm performance.

  7. Integrated Optical Interconnect Architectures for Embedded Systems

    CERN Document Server

    Nicolescu, Gabriela

    2013-01-01

    This book provides a broad overview of current research in optical interconnect technologies and architectures. Introductory chapters on high-performance computing and the associated issues in conventional interconnect architectures, and on the fundamental building blocks for integrated optical interconnect, provide the foundations for the bulk of the book which brings together leading experts in the field of optical interconnect architectures for data communication. Particular emphasis is given to the ways in which the photonic components are assembled into architectures to address the needs of data-intensive on-chip communication, and to the performance evaluation of such architectures for specific applications.   Provides state-of-the-art research on the use of optical interconnects in Embedded Systems; Begins with coverage of the basics for high-performance computing and optical interconnect; Includes a variety of on-chip optical communication topologies; Features coverage of system integration and opti...

  8. An integrated system for genetic analysis

    Directory of Open Access Journals (Sweden)

    Duan Xiao

    2006-04-01

    Full Text Available Abstract Background Large-scale genetic mapping projects require data management systems that can handle complex phenotypes and detect and correct high-throughput genotyping errors, yet are easy to use. Description We have developed an Integrated Genotyping System (IGS to meet this need. IGS securely stores, edits and analyses genotype and phenotype data. It stores information about DNA samples, plates, primers, markers and genotypes generated by a genotyping laboratory. Data are structured so that statistical genetic analysis of both case-control and pedigree data is straightforward. Conclusion IGS can model complex phenotypes and contain genotypes from whole genome association studies. The database makes it possible to integrate genetic analysis with data curation. The IGS web site http://bioinformatics.well.ox.ac.uk/project-igs.shtml contains further information.

  9. Large-scale integration of small molecule-induced genome-wide transcriptional responses, Kinome-wide binding affinities and cell-growth inhibition profiles reveal global trends characterizing systems-level drug action

    Directory of Open Access Journals (Sweden)

    Dusica eVidovic

    2014-09-01

    Full Text Available The Library of Integrated Network-based Cellular Signatures (LINCS project is a large-scale coordinated effort to build a comprehensive systems biology reference resource. The goals of the program include the generation of a very large multidimensional data matrix and informatics and computational tools to integrate, analyze, and make the data readily accessible. LINCS data include genome-wide transcriptional signatures, biochemical protein binding profiles, cellular phenotypic response profiles and various other datasets for a wide range of cell model systems and molecular and genetic perturbations. Here we present a partial survey of this data facilitated by data standards and in particular a robust compound standardization workflow; we integrated several types of LINCS signatures and analyzed the results with a focus on mechanism of action and chemical compounds. We illustrate how kinase targets can be related to disease models and relevant drugs. We identified some fundamental trends that appear to link Kinome binding profiles and transcriptional signatures to chemical information and biochemical binding profiles to transcriptional responses independent of chemical similarity. To fill gaps in the datasets we developed and applied predictive models. The results can be interpreted at the systems level as demonstrated based on a large number of signaling pathways. We can identify clear global relationships, suggesting robustness of cellular responses to chemical perturbation. Overall, the results suggest that chemical similarity is a useful measure at the systems level, which would support phenotypic drug optimization efforts. With this study we demonstrate the potential of such integrated analysis approaches and suggest prioritizing further experiments to fill the gaps in the current data.

  10. Large-scale integration of small molecule-induced genome-wide transcriptional responses, Kinome-wide binding affinities and cell-growth inhibition profiles reveal global trends characterizing systems-level drug action.

    Science.gov (United States)

    Vidović, Dušica; Koleti, Amar; Schürer, Stephan C

    2014-01-01

    The Library of Integrated Network-based Cellular Signatures (LINCS) project is a large-scale coordinated effort to build a comprehensive systems biology reference resource. The goals of the program include the generation of a very large multidimensional data matrix and informatics and computational tools to integrate, analyze, and make the data readily accessible. LINCS data include genome-wide transcriptional signatures, biochemical protein binding profiles, cellular phenotypic response profiles and various other datasets for a wide range of cell model systems and molecular and genetic perturbations. Here we present a partial survey of this data facilitated by data standards and in particular a robust compound standardization workflow; we integrated several types of LINCS signatures and analyzed the results with a focus on mechanism of action (MoA) and chemical compounds. We illustrate how kinase targets can be related to disease models and relevant drugs. We identified some fundamental trends that appear to link Kinome binding profiles and transcriptional signatures to chemical information and biochemical binding profiles to transcriptional responses independent of chemical similarity. To fill gaps in the datasets we developed and applied predictive models. The results can be interpreted at the systems level as demonstrated based on a large number of signaling pathways. We can identify clear global relationships, suggesting robustness of cellular responses to chemical perturbation. Overall, the results suggest that chemical similarity is a useful measure at the systems level, which would support phenotypic drug optimization efforts. With this study we demonstrate the potential of such integrated analysis approaches and suggest prioritizing further experiments to fill the gaps in the current data.

  11. A BACTERIA FORAGING ALGORITHM FOR SOLVING INTEGRATED MULTI-PERIOD CELL FORMATION AND SUBCONTRACTING PRODUCTION PLANNING IN A DYNAMIC CELLULAR MANUFACTURING SYSTEM

    Directory of Open Access Journals (Sweden)

    S.H. Tang

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: The bacteria foraging algorithm (BFA is a new computation technique inspired by the social foraging behaviour of Escherichia coli (E. coli bacteria. Since the introduction of the BFA by Kevin M. Passino, there have been many challenges in employing this algorithm to problems other than those for which the algorithm was proposed. This research aims to apply this emerging optimisation algorithm to develop a mixed-integer programming model for designing cellular manufacturing systems (CMSs, and production planning in dynamic environments. In dynamic environments, product mix and part demand vary under multi-period planning horizons. Thus the best-designed cells for one period may not be adequate for subsequent periods, requiring their reconstruction. The advantages of the proposed model are as follows: consideration of batch inter-cell and intra-cell material handling by assuming the sequence of operations, allowing for alternative process plans for part types, and consideration of machine copying, with an emphasis on the effect of trade-offs between production and outsourcing costs. The goal is to minimise the sum of the machines’ constant and variable costs, inter-cell and intra-cell material handling costs, reconstruction costs, partial subcontracting costs, and inventory carrying costs. In addition, a newly-developed BFA-based optimisation algorithm has been compared with the branch and bound algorithm. The results suggest that the proposed algorithm performs better than related works.

    AFRIKAANSE OPSOMMING: Die ‘bacteria foraging algorithm’ (BFA is ‘n berekeningstegniek gebaseeer op die sosiale soekgedrag van Escherichia coli (E. coli bakterieë. Sedert die bekendstelling van BFA was daar talle uitdagings oor toepassings van die algoritme op ander probleme as dié waarvoor dit ontwikkel is. Dié navorsing poog om deur toepassing van die algoritme ‘n gemengde heelgetalprogrammeringmodel te ontwikkel vir die

  12. Solvability of the $G_2$ Integrable System

    CERN Document Server

    Capella, A; Turbiner, A V; Capella, Antonio; Rosenbaum, Marcos; Turbiner, Alexander

    1997-01-01

    It is shown that the 3-body trigonometric G_2 integrable system is exactly-solvable. If the configuration space is parametrized by certain symmetric functions of the coordinates then, for arbitrary values of the coupling constants, the Hamiltonian can be expressed as a quadratic polynomial in the generators of some Lie algebra of differential operators in a finite-dimensional representation. Four infinite families of eigenstates, represented by polynomials, and the corresponding eigenvalues are described explicitly.

  13. EME banking systems and regional financial integration

    OpenAIRE

    Bank for International Settlements

    2014-01-01

    This report - prepared by a Study Group chaired by Andrew Khoo (Monetary Authority of Singapore) - develops a central bank perspective on the regional integration of EME banking systems and financial markets, assesses the drivers of these developments, and draws broad conclusions for policymakers. The findings are based on data from the BIS international banking statistics (IBS) and various other public sources, interviews with the private sector, inputs from central banks from non-CGFS juris...

  14. On the equivalence theorem for integrable systems

    CERN Document Server

    Melikyan, A; Rivelles, V O

    2014-01-01

    We investigate the equivalence theorem for integrable systems using two formulations of the Alday-Arutyunov-Frolov model. We show that the S-matrix is invariant under the field transformation which reduces the non-linear Dirac brackets of one formulation into the standard commutation relations in the second formulation. We also explain how to perform the direct diagonalization of the transformed Hamiltonian by constructing the states corresponding to self-adjoint extensions.

  15. Kite Generator System: Grid Integration and Validation

    OpenAIRE

    Ahmed, Mariam; Hably, Ahmad; Bacha, Seddik; Ovalle, Andres

    2014-01-01

    International audience; In this paper, the problem of grid integration of a kite generator system (KGS), is handled. The mechanical power generated by the kite's traction is translated into an electrical one via a permanent magnet synchronous machine. This power is then injected in the grid or used to supply an isolated load after passing a power electronics interface. Control schemes have been developed for grid connected or stand-alone operation and tested on a hardware-in-the-loop simulator.

  16. Note on quantum groups and integrable systems

    Science.gov (United States)

    Popolitov, A.

    2016-01-01

    The free-field formalism for quantum groups [preprint ITEP-M3/94, CRM-2202 hep-th/9409093] provides a special choice of coordinates on a quantum group. In these coordinates the construction of associated integrable system [arXiv:1207.1869] is especially simple. This choice also fits into general framework of cluster varieties [math.AG/0311245]—natural changes in coordinates are cluster mutations.

  17. Integrated soldier power and data system (ISPDS)

    Science.gov (United States)

    Ostroumov, Roman; Forrester, Thomas; Lee, Kang; Stephens, Robert; Lai, Anthony; Zahzah, Mohamad

    2014-06-01

    Physical Optics Corporation (POC) developed the body-worn Integrated Soldier Power and Data System (ISPDS), a configurable node for plug-in wired or wireless server/client or peer-to-peer computing with accommodations for power, sensor I/O interfaces, and energy harvesting. The enabling technology increases the efficacy of uniformed personnel and first responders and provides an option for reducing force structure associated with the need for hardware network infrastructure to enable a mobile digital communications architecture for dismounted troops. The ISPDS system addresses the DoD's need for an "intelligent" power control system in an effort to increase mission duration and maximize the first responders and warfighter's effectiveness without concern for the available energy resources (i.e., batteries). ISPDS maximizes durability and survivability, assesses influences that affect performance, and provides the network backbone and mobile node hardware. POC is producing two vest-integrated variants, one each for the U.S. Army PEO Ground Soldier and the Air Soldier, with each including state-of-the-art low-profile and robust wearable connectors, cabling, and harnesses, and an integrated low-profile power manager and conformal battery for data and power distribution. The innovative intelligent power controller (IPC), in the form of the ISPDS firmware and power sensing and control electronics, will enable ISPDS to optimize power levels both automatically and in accordance with manually set preferences. The IPC module is power dense and efficient, and adaptively provides lossless transfer of available harvested photovoltaic energy to the battery. The integrated systems were tested for suitable electrical, electromagnetic interference (EMI), and environmental performance as outlined in military standards such as MIL-STD- 810G and MIL STD-461F.

  18. Multistep Methods for Integrating the Solar System

    Science.gov (United States)

    1988-07-01

    Technical Report 1055 [Multistep Methods for Integrating the Solar System 0 Panayotis A. Skordos’ MIT Artificial Intelligence Laboratory DTIC S D g8...RMA ELEENT. PROECT. TASK Artific ial Inteligence Laboratory ARE1A G WORK UNIT NUMBERS 545 Technology Square Cambridge, MA 02139 IL. CONTROLLING...describes research done at the Artificial Intelligence Laboratory of the Massachusetts Institute of Technology, supported by the Advanced Research Projects

  19. Nano-to-Millimeter Scale Integrated Systems

    Science.gov (United States)

    1999-01-01

    Millimeter Scale Integrated Systems H. Last, M. Deeds, D. Garvick, R. Kavetsky Naval Surface Warfare Center, Indian Head Division P. Sandborn, E. B. Magrab...ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Surface Warfare Center,Indian Head Division,101 Strauss Avenue,Indian Head ,MD,20640 8. PERFORMING ORGANIZATION...strategic planning in the area of electronic products development and marketing . Dr. Pecht is an ASME Fellow. He served as Chief Editor of the IEEE

  20. System design and integration analysis for the Integrated Booking System (IBS)

    Energy Technology Data Exchange (ETDEWEB)

    Truett, L.F.; Wheeler, V.V.; Grubb, J.W. [Oak Ridge National Laboratory, TN (United States); Grubb, J.W.; Faby, E.Z. [Univ. of Tennessee, Knoxville, TN (United States)

    1995-11-01

    In accordance with tasking for the Military Traffic Management Command (MTMC), the Oak Ridge National Laboratory (ORNL) investigated design and integration issues and identified specific options for MTMC`s Integrated Booking System (IBS). Three system designs are described: the single-server, stand-alone IBS; the area-based IBS; and the fully-integrated IBS. Because of the functional and technical requirements of IBS and because of the MTMC strategy of sharing resources, ORNL recommends the fully-integrated design. This option uses the excess computing resources provided through the architectural components of the Integrated Cargo Database (ICDB) and provides visibility over the cargo record from initial request through final delivery.

  1. Toward an integrated system of clade names.

    Science.gov (United States)

    de Queiroz, Kevin

    2007-12-01

    Although the proposition that higher taxa should correspond to clades is widely accepted, current nomenclature does not distinguish clearly between different clades in nested series. In particular, the same name is often applied to a total clade, its crown clade, and clades originating with various nodes, branches, and apomorphies in between. An integrated system of clade names is described based on categories of clades defined with respect to lineages that have survived to the present time. In this system, the most widely known names are applied to crown clades, the names of total clades are formed by adding a standard prefix to the names of the corresponding crowns, and the names of apomorphy clades describe the specific apomorphies with which they originated. Relative to traditional approaches, this integrated approach to naming clades is both more precise concerning the associations of names with particular clades and more efficient with regard to the cognitive effort required to recognize the names of corresponding crown and total clades. It also seems preferable to five alternatives that could be used to make the same distinctions. The integrated system of clade names has several advantages, including the facilitation of communication among biologists who study distantly related clades, promoting a broader conceptualization of the origins of distinctive clades of extant organisms and emphasizing the continuous nature of evolution.

  2. METHODS OF INTEGRATED OPTIMIZATION MAGLEV TRANSPORT SYSTEMS

    Directory of Open Access Journals (Sweden)

    A. Lasher

    2013-09-01

    Full Text Available Purpose. To demonstrate feasibility of the proposed integrated optimization of various MTS parameters to reduce capital investments as well as decrease any operational and maintenance expense. This will make use of MTS reasonable. At present, the Maglev Transport Systems (MTS for High-Speed Ground Transportation (HSGT almost do not apply. Significant capital investments, high operational and maintenance costs are the main reasons why Maglev Transport Systems (MTS are hardly currently used for the High-Speed Ground Transportation (HSGT. Therefore, this article justifies use of Theory of Complex Optimization of Transport (TCOT, developed by one of the co-authors, to reduce MTS costs. Methodology. According to TCOT, authors developed an abstract model of the generalized transport system (AMSTG. This model mathematically determines the optimal balance between all components of the system and thus provides the ultimate adaptation of any transport systems to the conditions of its application. To identify areas for effective use of MTS, by TCOT, the authors developed a dynamic model of distribution and expansion of spheres of effective use of transport systems (DMRRSEPTS. Based on this model, the most efficient transport system was selected for each individual track. The main estimated criterion at determination of efficiency of application of MTS is the size of the specific transportation tariff received from calculation of payback of total given expenses to a standard payback period or term of granting the credit. Findings. The completed multiple calculations of four types of MTS: TRANSRAPID, MLX01, TRANSMAG and TRANSPROGRESS demonstrated efficiency of the integrated optimization of the parameters of such systems. This research made possible expending the scope of effective usage of MTS in about 2 times. The achieved results were presented at many international conferences in Germany, Switzerland, United States, China, Ukraine, etc. Using MTS as an

  3. Assessment of Integrated Information System (IIS) in organization ...

    African Journals Online (AJOL)

    Assessment of Integrated Information System (IIS) in organization. ... Journal of Research in National Development ... This research contributes to the field of Information Systems specifically in the area of Integrated Information System ...

  4. Dexamethasone Rescues Neurovascular Unit Integrity from Cell Damage Caused by Systemic Administration of Shiga Toxin 2 and Lipopolysaccharide in Mice Motor Cortex

    Science.gov (United States)

    Pinto, Alipio; Jacobsen, Mariana; Geoghegan, Patricia A.; Cangelosi, Adriana; Cejudo, María Laura; Tironi-Farinati, Carla; Goldstein, Jorge

    2013-01-01

    Shiga toxin 2 (Stx2)-producing Escherichia coli (STEC) causes hemorrhagic colitis and hemolytic uremic syndrome (HUS) that can lead to fatal encephalopathies. Neurological abnormalities may occur before or after the onset of systemic pathological symptoms and motor disorders are frequently observed in affected patients and in studies with animal models. As Stx2 succeeds in crossing the blood-brain barrier (BBB) and invading the brain parenchyma, it is highly probable that the observed neurological alterations are based on the possibility that the toxin may trigger the impairment of the neurovascular unit and/or cell damage in the parenchyma. Also, lipopolysaccharide (LPS) produced and secreted by enterohemorrhagic Escherichia coli (EHEC) may aggravate the deleterious effects of Stx2 in the brain. Therefore, this study aimed to determine (i) whether Stx2 affects the neurovascular unit and parenchymal cells, (ii) whether the contribution of LPS aggravates these effects, and (iii) whether an inflammatory event underlies the pathophysiological mechanisms that lead to the observed injury. The administration of a sub-lethal dose of Stx2 was employed to study in detail the motor cortex obtained from a translational murine model of encephalopathy. In the present paper we report that Stx2 damaged microvasculature, caused astrocyte reaction and neuronal degeneration, and that this was aggravated by LPS. Dexamethasone, an anti-inflammatory, reversed the pathologic effects and proved to be an important drug in the treatment of acute encephalopathies. PMID:23894578

  5. Dexamethasone rescues neurovascular unit integrity from cell damage caused by systemic administration of shiga toxin 2 and lipopolysaccharide in mice motor cortex.

    Directory of Open Access Journals (Sweden)

    Alipio Pinto

    Full Text Available Shiga toxin 2 (Stx2-producing Escherichia coli (STEC causes hemorrhagic colitis and hemolytic uremic syndrome (HUS that can lead to fatal encephalopathies. Neurological abnormalities may occur before or after the onset of systemic pathological symptoms and motor disorders are frequently observed in affected patients and in studies with animal models. As Stx2 succeeds in crossing the blood-brain barrier (BBB and invading the brain parenchyma, it is highly probable that the observed neurological alterations are based on the possibility that the toxin may trigger the impairment of the neurovascular unit and/or cell damage in the parenchyma. Also, lipopolysaccharide (LPS produced and secreted by enterohemorrhagic Escherichia coli (EHEC may aggravate the deleterious effects of Stx2 in the brain. Therefore, this study aimed to determine (i whether Stx2 affects the neurovascular unit and parenchymal cells, (ii whether the contribution of LPS aggravates these effects, and (iii whether an inflammatory event underlies the pathophysiological mechanisms that lead to the observed injury. The administration of a sub-lethal dose of Stx2 was employed to study in detail the motor cortex obtained from a translational murine model of encephalopathy. In the present paper we report that Stx2 damaged microvasculature, caused astrocyte reaction and neuronal degeneration, and that this was aggravated by LPS. Dexamethasone, an anti-inflammatory, reversed the pathologic effects and proved to be an important drug in the treatment of acute encephalopathies.

  6. Integrated Microfluidic Sensor System with Magnetostrictive Resonators

    KAUST Repository

    Liang, Cai

    2011-12-08

    The present embodiments describe a method that integrates a magnetostrictive sensor with driving and detecting elements into a microfluidic chip to detect a chemical, biochemical or biomedical species. These embodiments may also measure the properties of a fluid such as viscosity, pH values. The whole system can be referred to lab-on-a-chip (LOC) or micro-total-analysis-systems (.mu.TAS). In particular, this present embodiments include three units, including a microfluidics unit, a magnetostrictive sensor, and driving/detecting elements. An analyzer may also be provided to analyze an electrical signal associated with a feature of a target specimen.

  7. On-Chip Integration of Cell-Free Gene Expression

    Science.gov (United States)

    Buxboim, Amnon; Morpurgo, Margherita; Bar-Dagan, Maya; Frydman, Veronica; Zbaida, David; Bar-Ziv, Roy

    2006-03-01

    We present a synthetic approach for the study of gene networks in vitro which is complementary to traditional in vivo methodologies. We have developed a technology for submicron integration of functional genes and on-chip protein synthesis using a cell-free transcription/translation system. The interaction between genes is facilitated by diffusion of on-chip gene expression products from `source' genes towards `acceptor' genes. Our technology is simple and inexpensive and can serve as an improved platform for a wide variety of protein and DNA biochip applications.

  8. System Interface for an Integrated Intelligent Safety System (ISS for Vehicle Applications

    Directory of Open Access Journals (Sweden)

    Mahammad A. Hannan

    2010-01-01

    Full Text Available This paper deals with the interface-relevant activity of a vehicle integrated intelligent safety system (ISS that includes an airbag deployment decision system (ADDS and a tire pressure monitoring system (TPMS. A program is developed in LabWindows/CVI, using C for prototype implementation. The prototype is primarily concerned with the interconnection between hardware objects such as a load cell, web camera, accelerometer, TPM tire module and receiver module, DAQ card, CPU card and a touch screen. Several safety subsystems, including image processing, weight sensing and crash detection systems, are integrated, and their outputs are combined to yield intelligent decisions regarding airbag deployment. The integrated safety system also monitors tire pressure and temperature. Testing and experimentation with this ISS suggests that the system is unique, robust, intelligent, and appropriate for in-vehicle applications.

  9. Eigenstate Gibbs ensemble in integrable quantum systems

    Science.gov (United States)

    Nandy, Sourav; Sen, Arnab; Das, Arnab; Dhar, Abhishek

    2016-12-01

    The eigenstate thermalization hypothesis conjectures that for a thermodynamically large system in one of its energy eigenstates, the reduced density matrix describing any finite subsystem is determined solely by a set of relevant conserved quantities. In a chaotic quantum system, only the energy is expected to play that role and hence eigenstates appear locally thermal. Integrable systems, on the other hand, possess an extensive number of such conserved quantities and therefore the reduced density matrix requires specification of all the corresponding parameters (generalized Gibbs ensemble). However, here we show by unbiased statistical sampling of the individual eigenstates with a given finite energy density that the local description of an overwhelming majority of these states of even such an integrable system is actually Gibbs-like, i.e., requires only the energy density of the eigenstate. Rare eigenstates that cannot be represented by the Gibbs ensemble can also be sampled efficiently by our method and their local properties are then shown to be described by appropriately truncated generalized Gibbs ensembles. We further show that the presence of these rare eigenstates differentiates the model from the chaotic case and leads to the system being described by a generalized Gibbs ensemble at long time under a unitary dynamics following a sudden quench, even when the initial state is a typical (Gibbs-like) eigenstate of the prequench Hamiltonian.

  10. Integrity monitoring in WLAN positioning systems

    Science.gov (United States)

    Yerubandi, Sri Phani; Kalgikar, Bhargav; Gunturu, Maheedhar; Akopian, David; Chen, Philip

    2009-05-01

    Indoor Positioning Systems using WLANs have become very popular in recent years. These systems are spawning a new class of applications like activity recognition, surveillance, context aware computing and location based services. While Global Positioning System (GPS) is the natural choice for providing navigation in outdoor environment, the urban environment places a significant challenge for positioning using GPS. The GPS signals can be significantly attenuated, and often completely blocked, inside buildings or in urban canyons. As the performance of GPS in indoor environments is not satisfactory, indoor positioning systems based on location fingerprinting of WLANs is being suggested as a viable alternative. The Indoor WLAN Positioning Systems suffer from several phenomena. One of the problems is the continual availability of access points, which directly affects the positioning accuracy. Integrity monitoring of WLAN localization, which computes WLAN positioning with different sets of access points is proposed as a solution for this problem. The positioning accuracy will be adequate for the sets which do not contain faulty or the access points which are offline, while the sets with such access points will fail and they will report random and inaccurate results. The proposed method identifies proper sets and identifies the rogue access points using prediction trajectories. The combination of prediction and correct access point set selection provides a more accurate result. This paper discusses about integrity monitoring method for WLAN devices and followed by how it monitors and developing the application on mobile platforms.

  11. Unlocking Flexibility: Energy Systems Integration [Guest Editorial

    Energy Technology Data Exchange (ETDEWEB)

    O' Malley, Mark; Kroposki, Benjamin

    2017-01-01

    The articles in this special section focus on energy systems integration (ESI). Electric power systems around the world are experiencing great changes, including the retirement of coal and nuclear plants along with a rapid increase in the use of natural gas turbines and variable renewable technologies such as wind and solar. There is also much more use of information and communications technologies to enhance the visibility and controllability of the grid. Flexibility of operation, the ability of a power system to respond to change in demand and supply, is critical to enable higher levels of variable generation. One way to unlock this potential flexibility is to tap into other energy domains. This concept of interconnecting energy domains is called ESI. ESI is the process of coordinating the operation and planning of energy systems across multiple pathways and/or geographical scales to deliver reliable, cost-effective energy services with minimal impact on the environment. Integrating energy domains adds flexibility to the electrical power system. ESI includes interactions among energy vectors and with other large-scale infrastructures including water, transport, and data and communications networks, which are an enabling technology for ESI.

  12. Integrated Neural Flight and Propulsion Control System

    Science.gov (United States)

    Kaneshige, John; Gundy-Burlet, Karen; Norvig, Peter (Technical Monitor)

    2001-01-01

    This paper describes an integrated neural flight and propulsion control system. which uses a neural network based approach for applying alternate sources of control power in the presence of damage or failures. Under normal operating conditions, the system utilizes conventional flight control surfaces. Neural networks are used to provide consistent handling qualities across flight conditions and for different aircraft configurations. Under damage or failure conditions, the system may utilize unconventional flight control surface allocations, along with integrated propulsion control, when additional control power is necessary for achieving desired flight control performance. In this case, neural networks are used to adapt to changes in aircraft dynamics and control allocation schemes. Of significant importance here is the fact that this system can operate without emergency or backup flight control mode operations. An additional advantage is that this system can utilize, but does not require, fault detection and isolation information or explicit parameter identification. Piloted simulation studies were performed on a commercial transport aircraft simulator. Subjects included both NASA test pilots and commercial airline crews. Results demonstrate the potential for improving handing qualities and significantly increasing survivability rates under various simulated failure conditions.

  13. System Integration - A Major Step toward Lab on a Chip

    Directory of Open Access Journals (Sweden)

    Liao Joseph C

    2011-05-01

    Full Text Available Abstract Microfluidics holds great promise to revolutionize various areas of biological engineering, such as single cell analysis, environmental monitoring, regenerative medicine, and point-of-care diagnostics. Despite the fact that intensive efforts have been devoted into the field in the past decades, microfluidics has not yet been adopted widely. It is increasingly realized that an effective system integration strategy that is low cost and broadly applicable to various biological engineering situations is required to fully realize the potential of microfluidics. In this article, we review several promising system integration approaches for microfluidics and discuss their advantages, limitations, and applications. Future advancements of these microfluidic strategies will lead toward translational lab-on-a-chip systems for a wide spectrum of biological engineering applications.

  14. System Integration - A Major Step toward Lab on a Chip

    Science.gov (United States)

    2011-01-01

    Microfluidics holds great promise to revolutionize various areas of biological engineering, such as single cell analysis, environmental monitoring, regenerative medicine, and point-of-care diagnostics. Despite the fact that intensive efforts have been devoted into the field in the past decades, microfluidics has not yet been adopted widely. It is increasingly realized that an effective system integration strategy that is low cost and broadly applicable to various biological engineering situations is required to fully realize the potential of microfluidics. In this article, we review several promising system integration approaches for microfluidics and discuss their advantages, limitations, and applications. Future advancements of these microfluidic strategies will lead toward translational lab-on-a-chip systems for a wide spectrum of biological engineering applications. PMID:21612614

  15. Enhanced integrated nonthermal treatment system study

    Energy Technology Data Exchange (ETDEWEB)

    Biagi, C.; Schwinkendorf, B.; Teheranian, B.

    1997-02-01

    The purpose of the Enhanced Nonthermal Treatment Systems (ENTS) study is to evaluate alternative configurations of one of the five systems evaluated in the Integrated Nonthermal Treatment Systems (INTS) study. Five alternative configurations are evaluated. Each is designed to enhance the final waste form performance by replacing grout with improved stabilization technologies, or to improve system performance by improving the destruction efficiency for organic contaminants. AU enhanced systems are alternative configurations of System NT-5, which has the following characteristics: Nonthermal System NT-5: (1) catalytic wet oxidation (CWO) to treat organic material including organic liquids, sludges, and soft (or combustible) debris, (2) thermal desorption of inorganic sludge and process residue, (3) washing of soil and inorganic debris with treatment by CWO of removed organic material, (4) metal decontamination by abrasive blasting, (5) stabilization of treated sludge, soil, debris, and untreated debris with entrained contamination in grout, and (6) stabilization of inorganic sludge, salts and secondary waste in polymer. System NT-5 was chosen because it was designed to treat combustible debris thereby minimizing the final waste form volume, and because it uses grout for primary stabilization. The enhanced nonthermal systems were studied to determine the cost and performance impact of replacing grout (a commonly used stabilization agent in the DOE complex) with improved waste stabilization methods such as vitrification and polymer.

  16. Integral Equation Solution for Biopotentials of Single Cells

    Science.gov (United States)

    Klee, Maurice; Plonsey, Robert

    1972-01-01

    A Fredholm integral equation of the second type is developed for the biopotentials of single cells. Two singularities arise in the numerical solution of this integral equation and methods for handling them are presented. The problem of a spherical cell in an applied uniform field is used to illustrate the technique. PMID:4655666

  17. The immobilization of GOX in slides for comet sssay provides a useful tool for investigation of the efficiency of the cellular DNA-integrity protecting system of the target cells.

    Directory of Open Access Journals (Sweden)

    Nikolay Petrovich Sirota

    2015-06-01

    Variation of DNA damage was evaluated by measuring changes of DNA amount of tails of the DNA-comets (%TDNA within digital images of the DNA-comets. Reliability of the differences between the control and experimental data was estimated using Student’s t-test. At first we optimized concentration of the ROS –generating system components (GOX and glucose. For this purpose we analyzed the influence of different concentration of GOX and glucose on the level of hydrogen peroxide induced DNA damage. We observed the non linear dependence between the increase of the concentration of glucose (Fig.1 or GOX (data not shown and DNA damage. Prolongation of the incubation time of the slides with glucose also resulted in the increase of the DNA damage (Fig. 2. In the second part of the work we studied the response of the DNA-integrity defense system of human whole blood leukocytes to the hydrogen peroxide using newly established GOX – glucose ROS-generating approach. We measured level of DNA damage immediately after the 5 minute treatment period and after the incubation of treated cells in PBS without glucose for 30 minutes. The results are present in the Table 1. In conclusion we would like to summarize that in present work we have shown successful application of agarose-gel immobilized GOX – glucose ROS-generating system for inducing DNA damage and studying DNA-integrity defense system in mammalian cells. We suppose that this approach will be useful for measurement of the intracellular antioxidant systems efficiency and for many other applications for DNA damage studies.

  18. Solar energy grid integration systems "SEGIS"

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2007-10-01

    The inevitable transformation of the electrical grid to a more distributed generation configuration requires solar system capabilities well beyond simple net-metered, grid-connected approaches. Time-of-use and peak-demand rate structures will require more sophisticated systems designs that integrate energy management and/or energy storage into the system architecture. Controlling power flow into and from the utility grid will be required to ensure grid reliability and power quality. Alternative protection strategies will also be required to accommodate large numbers of distributed energy sources. This document provides an overview of the R&D needs and describes some pathways to promising solutions. The solutions will, in many cases, require R&D of new components, innovative inverter/controllers, energy management systems, innovative energy storage and a suite of advanced control algorithms, technical methodologies, protocols and the associated communications. It is expected that these solutions will help to push the “advanced integrated system” and “smart grid” evolutionary processes forward in a faster but focused manner.

  19. Human Systems Integration (HSI) Practitioner's Guide

    Science.gov (United States)

    Zumbado, Jennifer Rochlis

    2015-01-01

    The NASA/SP-2015-3709, Human Systems Integration (HSI) Practitioner's Guide, also known as the "HSIPG," provides a tool for implementing HSI activities within the NASA systems engineering framework. The HSIPG is written to aid the HSI practitioner engaged in a program or project (P/P), and serves as a knowledge base to allow the practitioner to step into an HSI lead or team member role for NASA missions. Additionally, this HSIPG is written to address the role of HSI in the P/P management and systems engineering communities and aid their understanding of the value added by incorporating good HSI practices into their programs and projects. Through helping to build a community of knowledgeable HSI practitioners, this document also hopes to build advocacy across the Agency for establishing strong, consistent HSI policies and practices. Human Systems Integration (HSI) has been successfully adopted (and adapted) by several federal agencies-most notably the U.S. Department of Defense (DoD) and the Nuclear Regulatory Commission (NRC)-as a methodology for reducing system life cycle costs (LCCs). These cost savings manifest themselves due to reductions in required numbers of personnel, the practice of human-centered design, decreased reliance on specialized skills for operations, shortened training time, efficient logistics and maintenance, and fewer safety-related risks and mishaps due to unintended human/system interactions. The HSI process for NASA establishes how cost savings and mission success can be realized through systems engineering. Every program or project has unique attributes. This HSIPG is not intended to provide one-size-fits-all recommendations for HSI implementation. Rather, HSI processes should be tailored to the size, scope, and goals of individual situations. The instructions and processes identified here are best used as a starting point for implementing human-centered system concepts and designs across programs and projects of varying types, including

  20. INTEGRATED GASIFICATION COMBINED CYCLE PROJECT 2 MW FUEL CELL DEMONSTRATION

    Energy Technology Data Exchange (ETDEWEB)

    FuelCell Energy

    2005-05-16

    With about 50% of power generation in the United States derived from coal and projections indicating that coal will continue to be the primary fuel for power generation in the next two decades, the Department of Energy (DOE) Clean Coal Technology Demonstration Program (CCTDP) has been conducted since 1985 to develop innovative, environmentally friendly processes for the world energy market place. The 2 MW Fuel Cell Demonstration was part of the Kentucky Pioneer Energy (KPE) Integrated Gasification Combined Cycle (IGCC) project selected by DOE under Round Five of the Clean Coal Technology Demonstration Program. The participant in the CCTDP V Project was Kentucky Pioneer Energy for the IGCC plant. FuelCell Energy, Inc. (FCE), under subcontract to KPE, was responsible for the design, construction and operation of the 2 MW fuel cell power plant. Duke Fluor Daniel provided engineering design and procurement support for the balance-of-plant skids. Colt Engineering Corporation provided engineering design, fabrication and procurement of the syngas processing skids. Jacobs Applied Technology provided the fabrication of the fuel cell module vessels. Wabash River Energy Ltd (WREL) provided the test site. The 2 MW fuel cell power plant utilizes FuelCell Energy's Direct Fuel Cell (DFC) technology, which is based on the internally reforming carbonate fuel cell. This plant is capable of operating on coal-derived syngas as well as natural gas. Prior testing (1992) of a subscale 20 kW carbonate fuel cell stack at the Louisiana Gasification Technology Inc. (LGTI) site using the Dow/Destec gasification plant indicated that operation on coal derived gas provided normal performance and stable operation. Duke Fluor Daniel and FuelCell Energy developed a commercial plant design for the 2 MW fuel cell. The plant was designed to be modular, factory assembled and truck shippable to the site. Five balance-of-plant skids incorporating fuel processing, anode gas oxidation, heat recovery

  1. Electronic integrated disease surveillance system and pathogen asset control system.

    Science.gov (United States)

    Wahl, Tom G; Burdakov, Aleksey V; Oukharov, Andrey O; Zhilokov, Azamat K

    2012-06-20

    Electronic Integrated Disease Surveillance System (EIDSS) has been used to strengthen and support monitoring and prevention of dangerous diseases within One Health concept by integrating veterinary and human surveillance, passive and active approaches, case-based records including disease-specific clinical data based on standardised case definitions and aggregated data, laboratory data including sample tracking linked to each case and event with test results and epidemiological investigations. Information was collected and shared in secure way by different means: through the distributed nodes which are continuously synchronised amongst each other, through the web service, through the handheld devices. Electronic Integrated Disease Surveillance System provided near real time information flow that has been then disseminated to the appropriate organisations in a timely manner. It has been used for comprehensive analysis and visualisation capabilities including real time mapping of case events as these unfold enhancing decision making. Electronic Integrated Disease Surveillance System facilitated countries to comply with the IHR 2005 requirements through a data transfer module reporting diseases electronically to the World Health Organisation (WHO) data center as well as establish authorised data exchange with other electronic system using Open Architecture approach. Pathogen Asset Control System (PACS) has been used for accounting, management and control of biological agent stocks. Information on samples and strains of any kind throughout their entire lifecycle has been tracked in a comprehensive and flexible solution PACS.Both systems have been used in a combination and individually. Electronic Integrated Disease Surveillance System and PACS are currently deployed in the Republics of Kazakhstan, Georgia and Azerbaijan as a part of the Cooperative Biological Engagement Program (CBEP) sponsored by the US Defense Threat Reduction Agency (DTRA).

  2. Electronic Integrated Disease Surveillance System and Pathogen Asset Control System

    Directory of Open Access Journals (Sweden)

    Tom G. Wahl

    2012-06-01

    Full Text Available Electronic Integrated Disease Surveillance System (EIDSS has been used to strengthen and support monitoring and prevention of dangerous diseases within One Health concept by integrating veterinary and human surveillance, passive and active approaches, case-based records including disease-specific clinical data based on standardised case definitions and aggregated data, laboratory data including sample tracking linked to each case and event with test results and epidemiological investigations. Information was collected and shared in secure way by different means: through the distributed nodes which are continuously synchronised amongst each other, through the web service, through the handheld devices. Electronic Integrated Disease Surveillance System provided near real time information flow that has been then disseminated to the appropriate organisations in a timely manner. It has been used for comprehensive analysis and visualisation capabilities including real time mapping of case events as these unfold enhancing decision making. Electronic Integrated Disease Surveillance System facilitated countries to comply with the IHR 2005 requirements through a data transfer module reporting diseases electronically to the World Health Organisation (WHO data center as well as establish authorised data exchange with other electronic system using Open Architecture approach. Pathogen Asset Control System (PACS has been used for accounting, management and control of biological agent stocks. Information on samples and strains of any kind throughout their entire lifecycle has been tracked in a comprehensive and flexible solution PACS.Both systems have been used in a combination and individually. Electronic Integrated Disease Surveillance System and PACS are currently deployed in the Republics of Kazakhstan, Georgia and Azerbaijan as a part of the Cooperative Biological Engagement Program (CBEP sponsored by the US Defense Threat Reduction Agency (DTRA.

  3. Integrated Online Library Systems: Perspectives, Perceptions, and Practicalities.

    Science.gov (United States)

    De Gennaro, Richard

    1985-01-01

    Discussion of information and misinformation about integrated online library systems highlights capabilities and functions that should be offered by an integrated system, practicalities of purchasing a system, visions versus reality, library versus information automation, origins of integrated online systems in the 1960s and 1970s, and future…

  4. Integrated Assessment Systems for Chemical Warfare Material

    Energy Technology Data Exchange (ETDEWEB)

    A. M. Snyder; D. A. Verrill; G. L. Thinnes; K. D. Watts; R. J. McMorland

    1999-05-27

    The US Army must respond to a variety of situations involving suspect discovered, recovered, stored, and buried chemical warfare materiel (CWM). In some cases, the identity of the fill materiel and the status of the fusing and firing train cannot be visually determined due to aging of the container, or because the item is contained in an over-pack. In these cases, non-intrusive assessments are required to provide information to allow safe handling, storage, and disposal of the materiel. This paper will provide an overview of the integrated mobile and facility-based CWM assessment system prototypes that have been, and are being developed, at the Idaho National Engineering and Environmental Laboratory (INEEL) for the US Army Non-Stockpile Chemical Materiel Project. In addition, this paper will discuss advanced sensors being developed to enhance the capability of the existing and future assessment systems. The Phase I Mobile Munitions Assessment System (MMAS) is currently being used by the Army's Technical Escort Unit (TEU) at Dugway Proving Ground, Utah. This system includes equipment for non-intrusively identifying the munitions fill materiel and for assessing the condition and stability of the fuzes, firing trains, and other potential safety hazards. The system provides a self-contained, integrated command post including an on-board computer system, communications equipment, video and photographic equipment, weather monitoring equipment, and miscellaneous safety-related equipment. The Phase II MMAS is currently being tested and qualified for use by the INEEL and the US Army. The Phase II system contains several new assessment systems that significantly enhance the ability to assess CWM. A facility-based munitions assessment system prototype is being developed for the assessment of CWM stored in igloos at Pine Bluff Arsenal, Arkansas. This system is currently in the design and fabrication stages. Numerous CWM advanced sensors are being developed and tested, and

  5. ASPECTS REGARDING THE INTEGRATION OF THE MODERN INFORMATION SYSTEMS

    OpenAIRE

    Botezatu Cornelia Paulina; Carutasu George; Botezatu Cezar

    2010-01-01

    Developing an information system integration strategy, at enterprise level is one of the most difficult issues that the information systems managers must solve, within the present conditions. When settling the integration strategy, two aspects must mainly be taken into account: assuring a complete integration solution of the information systems and building an integration infrastructure of the applications. The present paper aims at presenting few aspects regarding the integration of the info...

  6. Communication System for CIMS Application Integration Platform

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    CIMS has seen the growth of multiple incompatible hardware architectur es, each architecture supporting several incompatible operating systems, and eac h platform operating with various incompatible development tools (e.g., programm ing language compilers, DBMS, etc.) and one or more incompatible graphic user in terfaces. Also, the growth of the Internet, the World-Wide Web, has introduced new dimensio ns of complexity into the development process. All of these must be dealt with a s the application is made workable in a distributed client-server environment. This paper outlines the architecture of a communication system for the CIMS appl ication integration platform. The communication system makes possible the reque st for service across heterogeneous platforms and networks, and provides some co mmon solutions to issues common to CIMS applications.

  7. Video integrated measurement system. [Diagnostic display devices

    Energy Technology Data Exchange (ETDEWEB)

    Spector, B.; Eilbert, L.; Finando, S.; Fukuda, F.

    1982-06-01

    A Video Integrated Measurement (VIM) System is described which incorporates the use of various noninvasive diagnostic procedures (moire contourography, electromyography, posturometry, infrared thermography, etc.), used individually or in combination, for the evaluation of neuromusculoskeletal and other disorders and their management with biofeedback and other therapeutic procedures. The system provides for measuring individual diagnostic and therapeutic modes, or multiple modes by split screen superimposition, of real time (actual) images of the patient and idealized (ideal-normal) models on a video monitor, along with analog and digital data, graphics, color, and other transduced symbolic information. It is concluded that this system provides an innovative and efficient method by which the therapist and patient can interact in biofeedback training/learning processes and holds considerable promise for more effective measurement and treatment of a wide variety of physical and behavioral disorders.

  8. SOA approach for integration of departmental systems.

    Science.gov (United States)

    Itälä, Timo; Ukkola, Jari; Virtanen, Aino; Mykkänen, Juha

    2008-01-01

    In this paper a unified method for integration of departmental systems into the main systems of a healthcare organization is described. The approach is based on combining Business Process Modeling (BPM) and Service Oriented Architecture (SOA) methods and technologies. A top-down approach is used for modeling the care process and supporting care services which in turn are decomposed down to such a level of granularity that they can be described and implemented as web services described with Web Services Description Language (WSDL) documents. Then a bottom-up approach is used for wrapping the existing departmental systems and their interfaces into web services using Enterprise Service Bus (ESB). Finally the orchestration of the services is described using executable Business Process Execution Language (BPEL) code.

  9. Integrating innate and adaptive immune cells: Mast cells as crossroads between regulatory and effector B and T cells.

    Science.gov (United States)

    Mekori, Yoseph A; Hershko, Alon Y; Frossi, Barbara; Mion, Francesca; Pucillo, Carlo E

    2016-05-05

    A diversity of immune mechanisms have evolved to protect normal tissues from infection, but from immune damage too. Innate cells, as well as adaptive cells, are critical contributors to the correct development of the immune response and of tissue homeostasis. There is a dynamic "cross-talk" between the innate and adaptive immunomodulatory mechanisms for an integrated control of immune damage as well as the development of the immune response. Mast cells have shown a great plasticity, modifying their behavior at different stages of immune response through interaction with effector and regulatory populations of adaptive immunity. Understanding the interplays among T effectors, regulatory T cells, B cells and regulatory B cells with mast cells will be critical in the future to assist in the development of therapeutic strategies to enhance and synergize physiological immune-modulator and -suppressor elements in the innate and adaptive immune system.

  10. Financial overview of integrated community energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Croke, K. G.; Hurter, A. P.; Lerner, E.; Breen, W.; Baum, J.

    1977-01-01

    This report is designed to analyze the commercialization potential of various concepts of community-scale energy systems that have been termed Integrated Community Energy Systems (ICES). A case analysis of alternative ICES concepts applied to a major metropolitan development complex is documented. The intent of this study is twofold: (1) to develop a framework for comparing ICES technologies to conventional energy supply systems and (2) to identify potential problems in the commercialization of new systems approaches to energy conservation. In brief, the ICES Program of the ERDA Office of Energy Conservation is intended to identify the opportunities for energy conservation in the community context through analysis, development, and/or demonstration of: location and design of buildings, building complexes, and infrastructure links; engineering and systems design of existing, emerging, and advanced energy production and delivery technologies and systems; regulatory designs for public planning, administration, and regulation of energy-conserving community development and energy services; and financial planning for energy-conserving community development and energy supply systems.

  11. Airborne laser sensors and integrated systems

    Science.gov (United States)

    Sabatini, Roberto; Richardson, Mark A.; Gardi, Alessandro; Ramasamy, Subramanian

    2015-11-01

    The underlying principles and technologies enabling the design and operation of airborne laser sensors are introduced and a detailed review of state-of-the-art avionic systems for civil and military applications is presented. Airborne lasers including Light Detection and Ranging (LIDAR), Laser Range Finders (LRF), and Laser Weapon Systems (LWS) are extensively used today and new promising technologies are being explored. Most laser systems are active devices that operate in a manner very similar to microwave radars but at much higher frequencies (e.g., LIDAR and LRF). Other devices (e.g., laser target designators and beam-riders) are used to precisely direct Laser Guided Weapons (LGW) against ground targets. The integration of both functions is often encountered in modern military avionics navigation-attack systems. The beneficial effects of airborne lasers including the use of smaller components and remarkable angular resolution have resulted in a host of manned and unmanned aircraft applications. On the other hand, laser sensors performance are much more sensitive to the vagaries of the atmosphere and are thus generally restricted to shorter ranges than microwave systems. Hence it is of paramount importance to analyse the performance of laser sensors and systems in various weather and environmental conditions. Additionally, it is important to define airborne laser safety criteria, since several systems currently in service operate in the near infrared with considerable risk for the naked human eye. Therefore, appropriate methods for predicting and evaluating the performance of infrared laser sensors/systems are presented, taking into account laser safety issues. For aircraft experimental activities with laser systems, it is essential to define test requirements taking into account the specific conditions for operational employment of the systems in the intended scenarios and to verify the performance in realistic environments at the test ranges. To support the

  12. What is integrability of discrete variational systems?

    Science.gov (United States)

    Boll, Raphael; Petrera, Matteo; Suris, Yuri B

    2014-02-08

    We propose a notion of a pluri-Lagrangian problem, which should be understood as an analogue of multi-dimensional consistency for variational systems. This is a development along the line of research of discrete integrable Lagrangian systems initiated in 2009 by Lobb and Nijhoff, however, having its more remote roots in the theory of pluriharmonic functions, in the Z-invariant models of statistical mechanics and their quasiclassical limit, as well as in the theory of variational symmetries going back to Noether. A d-dimensional pluri-Lagrangian problem can be described as follows: given a d-form [Formula: see text] on an m-dimensional space (called multi-time, m>d), whose coefficients depend on a sought-after function x of m independent variables (called field), find those fields x which deliver critical points to the action functionals [Formula: see text] for anyd-dimensional manifold Σ in the multi-time. We derive the main building blocks of the multi-time Euler-Lagrange equations for a discrete pluri-Lagrangian problem with d=2, the so-called corner equations, and discuss the notion of consistency of the system of corner equations. We analyse the system of corner equations for a special class of three-point two-forms, corresponding to integrable quad-equations of the ABS list. This allows us to close a conceptual gap of the work by Lobb and Nijhoff by showing that the corresponding two-forms are closed not only on solutions of (non-variational) quad-equations, but also on general solutions of the corresponding corner equations. We also find an example of a pluri-Lagrangian system not coming from a multi-dimensionally consistent system of quad-equations.

  13. VISYTER: versatile and integrated system for telerehabilitation.

    Science.gov (United States)

    Parmanto, Bambang; Saptono, Andi; Pramana, Gede; Pulantara, Wayan; Schein, Richard M; Schmeler, Mark R; McCue, Michael P; Brienza, David M

    2010-11-01

    The versatile and integrated system for telerehabilitation (VISYTER) is a software platform for developing various telerehabilitation applications. VISYTER has been designed to take into account the environments and requirements of rehabilitation services. The requirements considered in the platform design include minimal equipment beyond what is available in many rehabilitation settings, minimal maintenance, and ease of setup and operation. In addition, the platform has been designed to be able to adjust to different bandwidths, ranging from the very fast new generation of Internet to residential broadband connections. VISYTER is a secure integrated system that combines high-quality videoconferencing with access to electronic health records and other key tools in telerehabilitation such as stimuli presentation, remote multiple camera control, remote control of the display screen, and an eye contact teleprompter. The software platform is suitable for supporting low-volume services to homes, yet scalable to support high-volume enterprise-wide telehealth services. The VISYTER system has been used to develop a number of telerehabilitation applications, including a remote wheelchair prescription, adult autistic assessments, and international physical therapy teleconsultations. An evaluation of VISYTER for delivering a remote wheelchair prescription was conducted on 48 participants. Results of the evaluation indicate a high level of satisfaction from patients with the use of VISYTER. The versatility and cost-effectiveness of the platform has the potential for a wide range of telerehabilitation applications and potentially may lower the technical and economic barriers of telemedicine adoption.

  14. Integrated transport and renewable energy systems

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; Lund, Henrik; Nørgaard, Per

    2007-01-01

    transport. It is concluded that a 100 per cent renewable energy transport system is possible but is connected to significant challenges in the path towards it. Biomass is a limited resource and it is important to avoid effecting the production. The integration of the transport with the remaining energy......Governments worldwide aim at reducing CO2 emissions and expanding renewable energy. A key element in achieving such a goal is to use renewable energy in transport such as biofuels. However, efforts to promote single transport technologies and single fuels only represent a partial solution...

  15. 3D packaging for integrated circuit systems

    Energy Technology Data Exchange (ETDEWEB)

    Chu, D.; Palmer, D.W. [eds.

    1996-11-01

    A goal was set for high density, high performance microelectronics pursued through a dense 3D packing of integrated circuits. A {open_quotes}tool set{close_quotes} of assembly processes have been developed that enable 3D system designs: 3D thermal analysis, silicon electrical through vias, IC thinning, mounting wells in silicon, adhesives for silicon stacking, pretesting of IC chips before commitment to stacks, and bond pad bumping. Validation of these process developments occurred through both Sandia prototypes and subsequent commercial examples.

  16. Home Energy Management System - VOLTTRON Integration

    Energy Technology Data Exchange (ETDEWEB)

    2017-05-01

    In most Home Energy Management Systems (HEMS) available in the market, different devices running different communication protocols cannot interact with each other and exchange information. As a result of this integration, the information about different devices running different communication protocol can be accessible by other agents and devices running on VOLTTRON platform. The integration process can be used by any HEMS available in the market regardless of the programming language they use. If the existing HEMS provides an Application Programming Interface (API) based on the RESTFul architecture, that API can be used for integration. Our candidate HEMS in this project is home-assistant (Hass). An agent is implemented which can communicate with the Hass API and receives information about the devices loaded on the API. The agent publishes the information it receives on the VOLTTRON message bus so other agents can have access to this information. On the other side, for each type of devices, an agent is implemented such as Climate Agent, Lock Agent, Switch Agent, Light Agent, etc. Each of these agents is subscribed to the messages published on the message bus about their associated devices. These agents can also change the status of the devices by sending appropriate service calls to the API. Other agents and services on the platform can also access this information and coordinate their decision-making process based on this information.

  17. Integration of Heterogeneous Systems as Multi-Agent Systems

    Directory of Open Access Journals (Sweden)

    Ammar Lahlouhi

    2014-08-01

    Full Text Available Systems integration is a difficult matter particularly when its components are varied. The problem becomes even more difficult when such components are heterogeneous such as humans, robots and software systems. Currently, the humans are regarded as users of artificial systems (robots and software systems. This has several disadvantages such as: (1 incoherence of artificial systems exploitation where humans’ roles are not clear, and (2 vain research of a user’s universal model. In this paper, we adopted a cooperative approach where the system’s components are regarded as being of the same level and they cooperate for the service of the global system. We concretized such approach by considering humans, robots and software systems as autonomous agents assuming roles in an organization. The latter will be implemented as a multi-agent system developed using a multi-agent development methodology.

  18. Smooth prime integrals for quasi-integrable Hamiltonian systems

    Energy Technology Data Exchange (ETDEWEB)

    Chierchia, L.; Gallavotti, G. (Rome Univ. (Italy). Ist. di Matematica)

    1982-02-11

    A Hamiltonian with N degrees of freedom, analytic perturbation of a canonically integrable strictly nonisochronous analytic Hamiltonian, is considered. We show the existence of N functions on phase space and of class Csup(infinity) which are prime integrals for the perturbed motions on a suitable region whose Lebesgue measure tends to fill locally the phase space as the perturbation's magnitude approaches zero. An application to the perturbations of isochronous nonresonant linear oscillators is given.

  19. Boost Converter with Three-State Switching Cell and Integrated Magnetics

    DEFF Research Database (Denmark)

    Klimczak, Pawel; Munk-Nielsen, Stig

    2009-01-01

    Fuel cell systems often require high voltage gain and dc-dc step-up converter is a critical part. Scope of this paper is integration of inductor and transformer on a single core. Usage of integrated magnetics improves utilization of magnetic core and thus size and weight of the converter may...

  20. CellTracks cell analysis system for rare cell detection

    NARCIS (Netherlands)

    Kagan, Michael T.; Trainer, Michael N.; Bendele, Teresa; Rao, Chandra; Horton, Allen; Tibbe, Arjan G.; Greve, Jan; Terstappen, Leon W.M.M.

    2002-01-01

    The CellTracks system is a Compact Disk-based cell analyzer that, similar to flow cytometry, differentiates cells that are aligned while passing through focused laser beams. In CellTracks, only immuno-magnetically labeled cells are aligned and remain in position for further analysis. This feature is

  1. System for Secure Integration of Aviation Data

    Science.gov (United States)

    Kulkarni, Deepak; Wang, Yao; Keller, Rich; Chidester, Tom; Statler, Irving; Lynch, Bob; Patel, Hemil; Windrem, May; Lawrence, Bob

    2007-01-01

    The Aviation Data Integration System (ADIS) of Ames Research Center has been established to promote analysis of aviation data by airlines and other interested users for purposes of enhancing the quality (especially safety) of flight operations. The ADIS is a system of computer hardware and software for collecting, integrating, and disseminating aviation data pertaining to flights and specified flight events that involve one or more airline(s). The ADIS is secure in the sense that care is taken to ensure the integrity of sources of collected data and to verify the authorizations of requesters to receive data. Most importantly, the ADIS removes a disincentive to collection and exchange of useful data by providing for automatic removal of information that could be used to identify specific flights and crewmembers. Such information, denoted sensitive information, includes flight data (here signifying data collected by sensors aboard an aircraft during flight), weather data for a specified route on a specified date, date and time, and any other information traceable to a specific flight. The removal of information that could be used to perform such tracing is called "deidentification." Airlines are often reluctant to keep flight data in identifiable form because of concerns about loss of anonymity. Hence, one of the things needed to promote retention and analysis of aviation data is an automated means of de-identification of archived flight data to enable integration of flight data with non-flight aviation data while preserving anonymity. Preferably, such an automated means would enable end users of the data to continue to use pre-existing data-analysis software to identify anomalies in flight data without identifying a specific anomalous flight. It would then also be possible to perform statistical analyses of integrated data. These needs are satisfied by the ADIS, which enables an end user to request aviation data associated with de-identified flight data. The ADIS

  2. Integral Radiators for Next Generation Thermal Control Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Integral radiators integrate the primary structural system and the thermal rejection system into a dual function subsystem allowing for reduced weight. The design of...

  3. Integrated Systems Mitigate Land Degradation and Improve Agricultural System Sustainability

    Science.gov (United States)

    Landblom, Douglas; Senturklu, Songul; Cihacek, Larry; Brevik, Eric

    2017-04-01

    Rain-fed agricultural production supported by exogenous inputs is not sustainable because a continuous influx of expensive inputs (fertilizer, chemicals, fossil fuel, labor, tillage, and other) is required. Alternatives to traditional management allow natural occurring dynamic soil processes to provide the necessary microbial activity that supports nutrient cycling in balance with nature. Research designed to investigate the potential for integrated systems to replace expensive inputs has shown that healthy soils rich in soil organic matter (SOM) are the foundation upon which microbial nutrient cycling can reduce and eventually replace expensive fertilizer. No-till seed placement technology effectively replaces multiple-pass cultivation conserving stored soil water in semi-arid farming systems. In multi-crop rotations, cool- and warm-season crops are grown in sequence to meet goals of the integrated farming and ranching system, and each crop in the rotation complements the subsequent crop by supplying a continuous flow of essential SOM for soil nutrient cycling. Grazing animals serve an essential role in the system's sustainability as non-mechanized animal harvesters that reduce fossil fuel consumption and labor, and animal waste contributes soil nutrients to the system. Integrated systems' complementarity has contributed to greater soil nutrient cycling and crop yields, fertilizer reduction or elimination, greater yearling steer grazing net return, reduced cow wintering costs grazing crop residues, increased wildlife sightings, and reduced environmental footprint. Therefore, integrating crop and animal systems can reverse soil quality decline and adopting non-traditional procedures has resulted in a wider array of opportunities for sustainable agriculture and profitability.

  4. Hamiltonian Forms for a Hierarchy of Discrete Integrable Coupling Systems

    Institute of Scientific and Technical Information of China (English)

    XU Xi-Xiang; YANG Hong-Xiang; LU Rong-Wu

    2008-01-01

    A semi-direct sum of two Lie algebras of four-by-four matrices is presented, and a discrete four-by-fore matrix spectral problem is introduced. A hierarchy of discrete integrable coupling systems is derived. The obtained integrable coupling systems are all written in their Hamiltonian forms by the discrete variational identity. Finally, we prove that the lattice equations in the obtained integrable coupling systems are all Liouville integrable discrete Hamiltonian systems.

  5. Integrating systems Approaches into Pharmaceutical Sciences

    DEFF Research Database (Denmark)

    Westerhoff, H.V.; Mosekilde, Erik; Noe, C. R.

    2008-01-01

    of the conference was to promote the ‘Integration of Systems Approaches into Pharmaceutical Sciences’ in view of optimising the development of new effective drugs. And a challenge this is, considering both the high attrition rates in the pharmaceutical industry and the failure of finding definitive drug solutions......During the first week of December 2007, the European Federation for Pharmaceutical Sciences (EUFEPS) and BioSim, the major European Network of Excellence on Systems Biology, held a challenging conference on the use of mathematical models in the drug development process. More precisely, the purpose...... for many of the diseases that plague mankind today. The conference was co-sponsored by the American College of Clinical Pharmacology, the European Center for Pharmaceutical Medicine, and the Swiss Society of Pharmaceutical Sciences and, besides representatives from the European Regulatory Agencies and FDA...

  6. System Integration of Distributed Energy Resources

    DEFF Research Database (Denmark)

    Nyeng, Preben

    Besides their primary product – electricity – large central power stations supply socalled ancillary services that are necessary to maintain a secure and stable operation state of the electric power system. As the need for electricity from these units is being displaced by renewable energy sources...... units, including the ICT solutions that can facilitate the integration. Specifically, the international standard "IEC 61850-7-420 Communications systems for Distributed Energy Resources" is considered as a possible brick in the solution. This standard has undergone continuous development...... have been established. These models can be used for future investigations as well. A mixture of empirical and analytical methods have been used when defining the models and their parameters. The project concludes that distributed energy resources, including flexible demand, can contribute significantly...

  7. INTEGRATED ENERGY EFFICIENT WINDOW-WALL SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    Michael Arney, Ph.D.

    2002-12-31

    The building industry faces the challenge of reducing energy use while simultaneously improving construction methods and marketability. This paper describes the first phase of a project to address these concerns by designing an Integrated Window Wall System (IWWS) that can be commercialized. This work builds on previous research conducted during the 1990's by Lawrence Berkeley national Laboratories (LBNL). During this phase, the objective was to identify appropriate technologies, problems and issues and develop a number of design concepts. Four design concepts were developed into prototypes and preliminary energy analyses were conducted Three of these concepts (the foam wall, steel wall, and stiffened plate designs) showed particular potential for meeting the project objectives and will be continued into a second phase where one or two of the systems will be brought closer to commercialization.

  8. Integrating configuration workflows with project management system

    Science.gov (United States)

    Nilsen, Dimitri; Weber, Pavel

    2014-06-01

    The complexity of the heterogeneous computing resources, services and recurring infrastructure changes at the GridKa WLCG Tier-1 computing center require a structured approach to configuration management and optimization of interplay between functional components of the whole system. A set of tools deployed at GridKa, including Puppet, Redmine, Foreman, SVN and Icinga, provides the administrative environment giving the possibility to define and develop configuration workflows, reduce the administrative effort and improve sustainable operation of the whole computing center. In this presentation we discuss the developed configuration scenarios implemented at GridKa, which we use for host installation, service deployment, change management procedures, service retirement etc. The integration of Puppet with a project management tool like Redmine provides us with the opportunity to track problem issues, organize tasks and automate these workflows. The interaction between Puppet and Redmine results in automatic updates of the issues related to the executed workflow performed by different system components. The extensive configuration workflows require collaboration and interaction between different departments like network, security, production etc. at GridKa. Redmine plugins developed at GridKa and integrated in its administrative environment provide an effective way of collaboration within the GridKa team. We present the structural overview of the software components, their connections, communication protocols and show a few working examples of the workflows and their automation.

  9. Blood as integral system of an organism

    Directory of Open Access Journals (Sweden)

    Майя Розметовна Верголяс

    2016-02-01

    Full Text Available Relevance of use of hematological blood parameters for monitoring as markers of various physiological and pathological processes is substantiated. It is shown that the blood is an important system of the body, has all the reactive characteristics of tissues, its sensitivity to pathological stimuli is very high. The reaction of the organism to the irritation of toxic or infectious nature manifests itself in the change of quantitative composition of peripheral blood cells

  10. Reducing acquisition risk through integrated systems of systems engineering

    Science.gov (United States)

    Gross, Andrew; Hobson, Brian; Bouwens, Christina

    2016-05-01

    In the fall of 2015, the Joint Staff J7 (JS J7) sponsored the Bold Quest (BQ) 15.2 event and conducted planning and coordination to combine this event into a joint event with the Army Warfighting Assessment (AWA) 16.1 sponsored by the U.S. Army. This multipurpose event combined a Joint/Coalition exercise (JS J7) with components of testing, training, and experimentation required by the Army. In support of Assistant Secretary of the Army for Acquisition, Logistics, and Technology (ASA(ALT)) System of Systems Engineering and Integration (SoSE&I), Always On-On Demand (AO-OD) used a system of systems (SoS) engineering approach to develop a live, virtual, constructive distributed environment (LVC-DE) to support risk mitigation utilizing this complex and challenging exercise environment for a system preparing to enter limited user test (LUT). AO-OD executed a requirements-based SoS engineering process starting with user needs and objectives from Army Integrated Air and Missile Defense (AIAMD), Patriot units, Coalition Intelligence, Surveillance and Reconnaissance (CISR), Focused End State 4 (FES4) Mission Command (MC) Interoperability with Unified Action Partners (UAP), and Mission Partner Environment (MPE) Integration and Training, Tactics and Procedures (TTP) assessment. The SoS engineering process decomposed the common operational, analytical, and technical requirements, while utilizing the Institute of Electrical and Electronics Engineers (IEEE) Distributed Simulation Engineering and Execution Process (DSEEP) to provide structured accountability for the integration and execution of the AO-OD LVC-DE. As a result of this process implementation, AO-OD successfully planned for, prepared, and executed a distributed simulation support environment that responsively satisfied user needs and objectives, demonstrating the viability of an LVC-DE environment to support multiple user objectives and support risk mitigation activities for systems in the acquisition process.

  11. A Web-Based Integration Procedure for the Development of Reconfigurable Robotic Work-Cells

    Directory of Open Access Journals (Sweden)

    Paulo Ferreira

    2013-07-01

    Full Text Available Concepts related to the development of reconfigurable manufacturing systems (RMS and methodologies to provide the best practices in the processing industry and factory automation, such as system integration and web‐based technology, are major issues in designing next‐generation manufacturing systems (NGMS. Adaptable and integrable devices are crucial for the success of NGMS. In robotic cells the integration of manufacturing components is essential to accelerate system adaptability. Sensors, control architectures and communication technologies have contributed to achieving further agility in reconfigurable factories. In this work a web‐based robotic cell integration procedure is proposed to aid the identification of reconfigurable issues and requirements. This methodology is applied to an industrial robot manipulator to enhance system flexibility towards the development of a reconfigurable robotic platform.

  12. Treatment of pathological gambling - integrative systemic model.

    Science.gov (United States)

    Mladenović, Ivica; Lažetić, Goran; Lečić-Toševski, Dušica; Dimitrijević, Ivan

    2015-03-01

    Pathological gambling was classified under impulse control disorders within the International Classification of Diseases (ICD-10) (WHO 1992), but the most recent Diagnostic and Statistical Manual, 5th edition (DSM-V), (APA 2013), has recognized pathological gambling as a first disorder within a new diagnostic category of behavioral addictions - Gambling disorder. Pathological gambling is a disorder in progression, and we hope that our experience in the treatment of pathological gambling in the Daily Hospital for Addictions at The Institute of Mental Health, through the original "Integrative - systemic model" would be of use to colleagues, dealing with this pathology. This model of treatment of pathological gambling is based on multi-systemic approach and it primarily represents an integration of family and cognitive-behavioral therapy, with traces of psychodynamic, existential and pharmacotherapy. The model is based on the book "Pathological gambling - with self-help manual" by Dr Mladenovic and Dr Lazetic, and has been designed in the form of a program that lasts 10 weeks in the intensive phase, and then continues for two years in the form of "extended treatment" ("After care"). The intensive phase is divided into three segments: educational, insight with initial changes and analysis of the achieved changes with the definition of plans and areas that need to be addressed in the extended treatment. "Extended treatment" lasts for two years in the form of group therapy, during which there is a second order change of the identified patient, but also of other family members. Pathological gambling has been treated in the form of systemic-family therapy for more than 10 years at the Institute of Mental Health (IMH), in Belgrade. For second year in a row the treatment is carried out by the modern "Integrative-systemic model". If abstinence from gambling witihin the period of one year after completion of the intensive phase of treatment is taken as the main criterion of

  13. Digital cell counting device integrated with a single-cell array.

    Directory of Open Access Journals (Sweden)

    Tatsuya Saeki

    Full Text Available In this paper, we present a novel cell counting method accomplished using a single-cell array fabricated on an image sensor, complementary metal oxide semiconductor sensor. The single-cell array was constructed using a microcavity array, which can trap up to 7,500 single cells on microcavities periodically arranged on a plane metallic substrate via the application of a negative pressure. The proposed method for cell counting is based on shadow imaging, which uses a light diffraction pattern generated by the microcavity array and trapped cells. Under illumination, the cell-occupied microcavities are visualized as shadow patterns in an image recorded by the complementary metal oxide semiconductor sensor due to light attenuation. The cell count is determined by enumerating the uniform shadow patterns created from one-on-one relationships with single cells trapped on the microcavities in digital format. In the experiment, all cell counting processes including entrapment of non-labeled HeLa cells from suspensions on the array and image acquisition of a wide-field-of-view of 30 mm(2 in 1/60 seconds were implemented in a single integrated device. As a result, the results from the digital cell counting had a linear relationship with those obtained from microscopic observation (r(2  = 0.99. This platform could be used at extremely low cell concentrations, i.e., 25-15,000 cells/mL. Our proposed system provides a simple and rapid miniaturized cell counting device for routine laboratory use.

  14. CMDS System Integration and IAMD End-to-End Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — The Cruise Missile Defense Systems (CMDS) Project Office is establishing a secure System Integration Laboratory at the AMRDEC. This lab will contain tactical Signal...

  15. Aviation Systems Test and Integration Lab (AvSTIL)

    Data.gov (United States)

    Federal Laboratory Consortium — The Aviation Systems Test and Integration Laboratory offers an innovative approach to aviation system and subsystem testing by fully immersing aviation platforms in...

  16. K West integrated water treatment system subproject safety analysis document

    Energy Technology Data Exchange (ETDEWEB)

    SEMMENS, L.S.

    1999-02-24

    This Accident Analysis evaluates unmitigated accident scenarios, and identifies Safety Significant and Safety Class structures, systems, and components for the K West Integrated Water Treatment System.

  17. Wearable smart systems: from technologies to integrated systems.

    Science.gov (United States)

    Lymberis, A

    2011-01-01

    Wearable technology and integrated systems, so called Smart Wearable Systems (SWS) have demonstrated during the last 10-15 years significant advances in terms of, miniaturisation, seamless integration, data processing & communication, functionalisation and comfort. This is mainly due to the huge progress in sciences and technologies e.g. biomedical and micro & nano technologies, but also to a strong demand for new applications such as continuous personal health monitoring, healthy lifestyle support, human performance monitoring and support of professionals at risk. Development of wearable systems based of smart textile have, in addition, benefited from the eagerness of textile industry to develop new value-added apparel products like functionalized garments and smart clothing. Research and development in these areas has been strongly promoted worldwide. In Europe the major R&D activities were supported through the Information & Communication Technologies (ICT) priority of the R&D EU programs. The paper presents and discusses the main achievements towards integrated systems as well as future challenges to be met in order to reach a market with reliable and high value-added products.

  18. A dynamic model of tomato fruit growth integrating cell division, cell growth and endoreduplication

    NARCIS (Netherlands)

    Fanwoua, J.; Visser, de P.H.B.; Heuvelink, E.; Yin, X.; Struik, P.C.; Marcelis, L.F.M.

    2013-01-01

    In this study, we developed a model of tomato (Solanum lycopersicum L.) fruit growth integrating cell division, cell growth and endoreduplication. The fruit was considered as a population of cells grouped in cell classes differing in their initial cell age and cell mass. The model describes fruit gr

  19. Model development of integrated CPOx reformer and SOFC stack system

    Directory of Open Access Journals (Sweden)

    Pianko-Oprych Paulina

    2016-12-01

    Full Text Available The main purpose of this study was to develop a mathematical model, in a steady state and dynamic mode, of a Catalytic Partial Oxidation (CPOx reformer – Solid Oxide Fuel Cell (SOFC stack integrated system in order to assess the system performance. Mass balance equations were written for each component in the system together with energy equation and implemented into the MATLAB Simulink simulation tool. Temperature, gas concentrations, pressure and current density were computed in the steady-state mode and validated against experimental data. The calculated I–V curve matched well the experimental one. In the dynamic modelling, several different conditions including step changes in fuel flow rates, stack voltage as well as temperature values were applied to estimate the system response against the load variations. Results provide valuable insight into the operating conditions that have to be achieved to ensure efficient CPOx performance for fuel processing for the SOFC stack applications.

  20. SENSOR FUSION CONTROL SYSTEM FOR COMPUTER INTEGRATED MANUFACTURING

    Directory of Open Access Journals (Sweden)

    C.M. Kumile

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: Manufacturing companies of today face unpredictable, high frequency market changes driven by global competition. To stay competitive, these companies must have the characteristics of cost-effective rapid response to the market needs. As an engineering discipline, mechatronics strives to integrate mechanical, electronic, and computer systems optimally in order to create high precision products and manufacturing processes. This paper presents a methodology of increasing flexibility and reusability of a generic computer integrated manufacturing (CIM cell-control system using simulation and modelling of mechatronic sensory system (MSS concepts. The utilisation of sensors within the CIM cell is highlighted specifically for data acquisition, analysis, and multi-sensor data fusion. Thus the designed reference architecture provides comprehensive insight for the functions and methodologies of a generic shop-floor control system (SFCS, which consequently enables the rapid deployment of a flexible system.

    AFRIKAANSE OPSOMMING: Hedendaagse vervaardigingsondernemings ervaar gereeld onvoorspelbare markveranderinge wat aangedryf word deur wêreldwye mededinging. Om kompeterend te bly moet hierdie ondernemings die eienskappe van kosteeffektiwiteit en snelle-respons op markfluktuasies toon. Megatronika streef daarna om meganiese, elektroniese en rekenaarstelsels optimaal te integreer om hoëpresisieprodukte en produksieprosesse daar te stel. Hierdie artikel suggereer 'n metodologie vir toenemende aanpasbaarheid en herbruikbaarheid van 'n generiese rekenaargeïntegreerde vervaardigingsel-beheersisteem deur die gebruik van simulasie en die modellering van megatroniese sensorsisteemkonsepte. Die aanwending van sensors binne die sel fasiliteer datavaslegging, ontleding en multisensordatafusie. Sodoende verskaf die ontwerpte argitektuur insig in die funksie en metodologie van 'n generiese stukwerkwinkelbeheersisteem wat die vinnige

  1. Specification and Generation of Adapters for System Integration

    NARCIS (Netherlands)

    Mooij, A.J.; Voorhoeve, M.

    2013-01-01

    Large systems-of-systems are developed by integrating several smaller systems that have been developed independently. System integration often requires adaptation mechanisms for bridging any technical incompatibilities between the systems. In order to develop adapters in a faster way, we study ways

  2. Integrated system brings hospital data together.

    Science.gov (United States)

    Johnson, K F

    1987-10-01

    Healthcare industry changes during the 1980s--increased competition and alterations in the Medicare payment methodology--place new and more complex demands on a hospital's information systems, which often fall short of meeting those demands. These systems were designed for financial reporting, billing, or providing clinical data, and few of them are capable of linking with other unrelated systems. Today's hospital manager needs timely and simultaneous access to data from a variety of sources within the hospital. All the elements to accomplish this are collected somewhere in the hospital, but finding them and bringing them together is difficult. The key to the efficient management and use of data bases is in understanding the fundamental concept of relational data bases, which is the capability of linking or joining separate data files through a common data element in each file. In this way, data files may be integrated into a "related" data base. Any number of separate files, or tables, may exist within a "relational" data base as long as a series of threads links them. A strategic management information data base includes the information necessary to analyze, understand, and manage the hospital's markets, products, resources, and profitability. The major components of this information system are the case mix and cost accounting, budgeting, and modeling systems. The case mix and cost accounting factors involve managing concrete pieces of data, whereas the budgeting and modeling factors manipulate data to create a scenario. The strategic management information data base is the foundation of a hospital's decision support system, which is rapidly moving into the category of a necessary tool of the hospital manager's trade.

  3. Integrating Data Mining Techniques into Telemedicine Systems

    Directory of Open Access Journals (Sweden)

    Mihaela GHEORGHE

    2014-01-01

    Full Text Available The medical system is facing a wide range of challenges nowadays due to changes that are taking place in the global healthcare systems. These challenges are represented mostly by economic constraints (spiraling costs, financial issues, but also, by the increased emphasis on accountability and transparency, changes that were made in the education field, the fact that the biomedical research keeps growing in what concerns the complexities of the specific studies etc. Also the new partnerships that were made in medical care systems and the great advances in IT industry suggest that a predominant paradigm shift is occurring. This needs a focus on interaction, collaboration and increased sharing of information and knowledge, all of these may is in turn be leading healthcare organizations to embrace the techniques of data mining in order to create and sustain optimal healthcare outcomes. Data mining is a domain of great importance nowadays as it provides advanced data analysis techniques for extracting the knowledge from the huge volumes of data collected and stored by every system of a daily basis. In the healthcare organizations data mining can provide valuable information for patient's diagnosis and treatment planning, customer relationship management, organization resources management or fraud detection. In this article we focus on describing the importance of data mining techniques and systems for healthcare organizations with a focus on developing and implementing telemedicine solution in order to improve the healthcare services provided to the patients. We provide architecture for integrating data mining techniques into telemedicine systems and also offer an overview on understanding and improving the implemented solution by using Business Process Management methods.

  4. Nuclear integrated database and design advancement system

    Energy Technology Data Exchange (ETDEWEB)

    Ha, Jae Joo; Jeong, Kwang Sub; Kim, Seung Hwan; Choi, Sun Young

    1997-01-01

    The objective of NuIDEAS is to computerize design processes through an integrated database by eliminating the current work style of delivering hardcopy documents and drawings. The major research contents of NuIDEAS are the advancement of design processes by computerization, the establishment of design database and 3 dimensional visualization of design data. KSNP (Korea Standard Nuclear Power Plant) is the target of legacy database and 3 dimensional model, so that can be utilized in the next plant design. In the first year, the blueprint of NuIDEAS is proposed, and its prototype is developed by applying the rapidly revolutionizing computer technology. The major results of the first year research were to establish the architecture of the integrated database ensuring data consistency, and to build design database of reactor coolant system and heavy components. Also various softwares were developed to search, share and utilize the data through networks, and the detailed 3 dimensional CAD models of nuclear fuel and heavy components were constructed, and walk-through simulation using the models are developed. This report contains the major additions and modifications to the object oriented database and associated program, using methods and Javascript.. (author). 36 refs., 1 tab., 32 figs.

  5. Integrable systems and symmetric products of curves

    CERN Document Server

    Vanhaecke, P

    1994-01-01

    show how there is associated to each non-constant polynomial F(x,y) a completely integrable system with polynomial invariants on \\Rd and on \\C{2d} for each d\\geq1; in fact the invariants are not only in involution for one Poisson bracket, but for a large class of polynomial Poisson brackets, indexed by the family of polynomials in two variables. We show that the complex invariant manifolds are isomorphic to affine parts of d-fold symmetric products of a deformation of the algebraic curve F(x,y)=0, and derive the structure of the real invariant manifolds from it. We also exhibit Lax equations for the hyperelliptic case (i.e., when F(x,y) is of the form y^2+f(x)) and we show that in this case the invariant manifolds are affine parts of distinguished (non-linear) subvarieties of the Jacobians of the curves. As an application the geometry of the H\\'enon-Heiles hierarchy --- a family of superimposable integrable polynomial potentials on the plane --- is revealed and Lax equations for the hierarchy are given.

  6. Energy Systems Integration: Demonstrating Distributed Grid-Edge Control Hierarchy

    Energy Technology Data Exchange (ETDEWEB)

    2017-01-01

    Overview fact sheet about the OMNETRIC Group Integrated Network Testbed for Energy Grid Research and Technology Experimentation (INTEGRATE) project at the Energy Systems Integration Facility. INTEGRATE is part of the U.S. Department of Energy's Grid Modernization Initiative.

  7. Energy Systems Integration: Demonstrating Distribution Feeder Voltage Control

    Energy Technology Data Exchange (ETDEWEB)

    2017-01-01

    Overview fact sheet about the Smarter Grid Solutions Integrated Network Testbed for Energy Grid Research and Technology Experimentation (INTEGRATE) project at the Energy Systems Integration Facility. INTEGRATE is part of the U.S. Department of Energy's Grid Modernization Initiative.

  8. Energy Systems Integration: Demonstrating the Grid Benefits of Connected Devices

    Energy Technology Data Exchange (ETDEWEB)

    2017-01-01

    Overview fact sheet about the Electric Power Research Institute (EPRI) and the University of Delaware Integrated Network Testbed for Energy Grid Research and Technology Experimentation (INTEGRATE) project at the Energy Systems Integration Facility. INTEGRATE is part of the U.S. Department of Energy's Grid Modernization Initiative.

  9. Random matrix theory, interacting particle systems and integrable systems

    CERN Document Server

    Forrester, Peter

    2014-01-01

    Random matrix theory is at the intersection of linear algebra, probability theory and integrable systems, and has a wide range of applications in physics, engineering, multivariate statistics and beyond. This volume is based on a Fall 2010 MSRI program which generated the solution of long-standing questions on universalities of Wigner matrices and beta-ensembles and opened new research directions especially in relation to the KPZ universality class of interacting particle systems and low-rank perturbations. The book contains review articles and research contributions on all these topics, in addition to other core aspects of random matrix theory such as integrability and free probability theory. It will give both established and new researchers insights into the most recent advances in the field and the connections among many subfields.

  10. Cell wall integrity signaling and innate immunity in plants.

    Science.gov (United States)

    Nühse, Thomas S

    2012-01-01

    All plant pathogens and parasites have had to develop strategies to overcome cell walls in order to access the host's cytoplasm. As a mechanically strong, multi-layered composite exoskeleton, the cell wall not only enables plants to grow tall but also protects them from such attacks. Many plant pathogens employ an arsenal of cell wall degrading enzymes, and it has long been thought that the detection of breaches in wall integrity contributes to the induction of defense. Cell wall fragments are danger-associated molecular patterns or DAMPs that can trigger defense signaling pathways comparable to microbial signals, but the picture is likely to be more complicated. A wide range of defects in cell wall biosynthesis leads to enhanced pathogen resistance. We are beginning to understand the essential role of cell wall integrity surveillance for plant growth, and the connection of processes like cell expansion, plasma membrane-cell wall contact and secondary wall biosynthesis with plant immunity is emerging.

  11. Global aspects of classical integrable systems

    CERN Document Server

    Cushman, Richard H

    2015-01-01

    This book gives a uniquely complete description of the geometry of the energy momentum mapping of five classical integrable systems: the 2-dimensional harmonic oscillator, the geodesic flow on the 3-sphere, the Euler top, the spherical pendulum and the Lagrange top. It presents for the first time in book form a general theory of symmetry reduction which allows one to reduce the symmetries in the spherical pendulum and the Lagrange top. Also the monodromy obstruction to the existence of global action angle coordinates is calculated for the spherical pendulum and the Lagrange top. The book addresses professional mathematicians and graduate students and can be used as a textbook on advanced classical mechanics or global analysis.

  12. Quasilocal charges in integrable lattice systems

    Science.gov (United States)

    Ilievski, Enej; Medenjak, Marko; Prosen, Tomaž; Zadnik, Lenart

    2016-06-01

    We review recent progress in understanding the notion of locality in integrable quantum lattice systems. The central concept concerns the so-called quasilocal conserved quantities, which go beyond the standard perception of locality. Two systematic procedures to rigorously construct families of quasilocal conserved operators based on quantum transfer matrices are outlined, specializing on anisotropic Heisenberg XXZ spin-1/2 chain. Quasilocal conserved operators stem from two distinct classes of representations of the auxiliary space algebra, comprised of unitary (compact) representations, which can be naturally linked to the fusion algebra and quasiparticle content of the model, and non-unitary (non-compact) representations giving rise to charges, manifestly orthogonal to the unitary ones. Various condensed matter applications in which quasilocal conservation laws play an essential role are presented, with special emphasis on their implications for anomalous transport properties (finite Drude weight) and relaxation to non-thermal steady states in the quantum quench scenario.

  13. Multi-Lagrangians for Integrable Systems

    CERN Document Server

    Nutku, Y

    2001-01-01

    We propose a general scheme to construct multiple Lagrangians for completely integrable non-linear evolution equations that admit multi-Hamiltonian structure. The recursion operator plays a fundamental role in this construction. We use a conserved quantity higher/lower than the Hamiltonian in the potential part of the new Lagrangian and determine the corresponding kinetic terms by generating the appropriate momentum map. This leads to some remarkable new developments. We show that nonlinear evolutionary systems that admit $N$-fold first order local Hamiltonian structure can be cast into variational form with $2N-1$ Lagrangians which will be local functionals of Clebsch potentials. Furthermore we construct a new Lagrangian for polytropic gas dynamics in 1+1 dimensions which is a {\\it local} functional of the physical field variables, namely density and velocity.

  14. CLARA: an integrated clinical research administration system.

    Science.gov (United States)

    Bian, Jiang; Xie, Mengjun; Hogan, William; Hutchins, Laura; Topaloglu, Umit; Lane, Cheryl; Holland, Jennifer; Wells, Thomas

    2014-10-01

    Administration of human subject research is complex, involving not only the institutional review board but also many other regulatory and compliance entities within a research enterprise. Its efficiency has a direct and substantial impact on the conduct and management of clinical research. In this paper, we report on the Clinical Research Administration (CLARA) platform developed at the University of Arkansas for Medical Sciences. CLARA is a comprehensive web-based system that can streamline research administrative tasks such as submissions, reviews, and approval processes for both investigators and different review committees on a single integrated platform. CLARA not only helps investigators to meet regulatory requirements but also provides tools for managing other clinical research activities including budgeting, contracting, and participant schedule planning.

  15. Whole-building systems integration laboratory survey

    Energy Technology Data Exchange (ETDEWEB)

    Crawley, D.B. (American Consulting Engineers Council, Washington, DC (USA). Research and Management Foundation)

    1989-09-01

    This report was prepared for the Pacific Northwest Laboratory as a subcontracted activity by the Research Management Foundation of the American Consulting Engineers Council. The objective of the survey reported herein was to independently assess the need for a Building System Integration Laboratory from the viewpoint of academicians in the field of building science. The subcontractor-developed questionnaire was sent to 200 professors of architecture and engineering at US universities. In view of this diverse population, the 10% rate of return on the questionnaire was considered acceptable. Although the responses probably do not reflect an unbiased summary of the collective perceptions of the original population surveyed, they do provide a valid insight into the interests and concerns of the academic community with respect to building sciences issues.

  16. Integrated polymer waveguides for absorbance detection in chemical analysis systems

    DEFF Research Database (Denmark)

    Mogensen, Klaus Bo; El-Ali, Jamil; Wolff, Anders

    2003-01-01

    . The emphasis of this paper is on the signal-to-noise ratio of the detection and its relation to the sensitivity. Two absorbance cells with an optical path length of 100 μm and 1000 μm were characterized and compared in terms of sensitivity, limit of detection and effective path length for measurements......A chemical analysis system for absorbance detection with integrated polymer waveguides is reported for the first time. The fabrication procedure relies on structuring of a single layer of the photoresist SU-8, so both the microfluidic channel network and the optical components, which include planar...

  17. Energy Systems Integration Partnerships: NREL + Cogent Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Berdahl, Sonja E [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-08-09

    NREL is collaborating with Cogent Energy Systems (Cogent) to introduce small-scale waste-to-energy technology in microgrids.The focus of the project is to test and demonstrate the feasibility, reliability, and usefulness of integrating electricity generated using a simulated syngas composition matching the syngas stream to be produced by a HelioStorm-based WTE gasifier to power a microgrid as a means of addressing and complementing the intermittency of other sources of electricity.

  18. THE INTEGRATED AGENT IN MULTI-AGENT SYSTEMS

    OpenAIRE

    Maleković, Mirko; Čubrilo, Mirko

    2000-01-01

    [n this paper, we characterize the integrated agent in multi-agent systems. The following result is proved: if a multi-agent system is reflexive (symmetric, transitive, Euclidean) then the integrated agent of the multi-agent system is reflexive (symmetric, transitive, Euclidean), respectively. We also prove that the analogous result does not hold for multi-agent system's serial ness. A knowledge relationship between the integrated agent and agents in a multiagent system is presented.

  19. Smart interface materials integrated with microfluidics for on-demand local capture and release of cells.

    Science.gov (United States)

    Gurkan, Umut Atakan; Tasoglu, Savas; Akkaynak, Derya; Avci, Oguzhan; Unluisler, Sebnem; Canikyan, Serli; Maccallum, Noah; Demirci, Utkan

    2012-09-01

    Stimuli responsive, smart interface materials are integrated with microfluidic technologies creating new functions for a broad range of biological and clinical applications by controlling the material and cell interactions. Local capture and on-demand local release of cells are demonstrated with spatial and temporal control in a microfluidic system.

  20. INTEGRATED VERTICAL AND OVERHEAD DECONTAMINATION (IVOD) SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    M.A. Ebadian, Ph.D.

    2001-01-01

    The deactivation and decommissioning of 1200 buildings within the U.S. Department of Energy-Office of Environmental Management complex will require the disposition of a large quantity of contaminated concrete and metal surfaces. It has been estimated that 23 million cubic meters of concrete and over 600,000 tons of metal will need disposition. The disposition of such large quantities of material presents difficulties in the area of decontamination and characterization. The final disposition of this large amount of material will take time and money as well as risk to the D&D work force. A single automated system that would decontaminate and characterize surfaces in one step would not only reduce the schedule and decrease cost during D&D operations but would also protect the D&D workers from unnecessary exposures to contaminated surfaces. This report summarizes the activities performed during FY00 and describes the planned activities for FY01. Accomplishments for FY00 include the following: Development and field-testing of characterization system; Completion of Title III design of deployment platform and decontamination unit; In-house testing of deployment platform and decontamination unit; Completion of system integration design; Identification of deployment site; and Completion of test plan document for deployment of IVOD at Rancho Seco nuclear power facility.