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Sample records for cell distribution width

  1. Red cell distribution width in type 2 diabetic patients

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    Nada AM

    2015-10-01

    Full Text Available Aml Mohamed Nada Department of Internal Medicine, Unit of Endocrinology, Diabetes and Metabolism, Faculty of Medicine, Mansoura University, Mansoura, Egypt Objective: To study the indices of some elements of the complete blood count, in type 2 diabetic patients, in comparison with nondiabetic healthy controls; and to find out the effects of glycemic control and different medications on these indices. To the best of our knowledge, this study is novel in our environment and will serve as a foundation for other researchers in this field. Methods: This retrospective study included 260 type 2 diabetic patients on treatment and 44 healthy control subjects. Sex, age, weight, height, blood pressure, complete blood count, fasting plasma glucose, hemoglobin A1c (HbA1c, and lipid profile data, were available for all of the study population. For diabetic patients, data on duration of diabetes and all medications were also available. Results: Red cell distribution width (RDW was significantly higher in diabetic patients than in control subjects (P=0.008. It was also higher in patients with uncontrolled glycemia (HbA1c >7% than those with good control (HbA1c ≤7%; P=0.035. Mean platelet volume (MPV was comparable in both diabetic patients and healthy controls (P=0.238. RDW and MPV did not significantly correlate with fasting plasma glucose, HbA1c, or duration of diabetes. Both aspirin and clopidogrel did not show a significant effect on MPV. Both insulin and oral hypoglycemic agents did not show a significant effect on RDW, mean corpuscular volume, MPV, platelet count, or white blood cell count. Diabetic patients treated with indapamide or the combined thiazides and angiotensin receptor blockers showed no significant difference in RDW when compared with the control subjects. Conclusion: RDW, which is recently considered as an inflammatory marker with a significant predictive value of mortality in diseased and healthy populations, is significantly higher in

  2. The role of red cell distribution width as a marker in inflammatory bowel disease

    OpenAIRE

    Arhan, Mehmet; ÖNAL, İbrahim Koral; Taş, Adnan; KURT, Mevlüt; Kalkan, İsmail Hakkı

    2011-01-01

    To determine whether red cell distribution width could be used for the assessment of disease activity in patients with inflammatory bowel disease. Materials and methods: A total of 165 patients with inflammatory bowel disease (105 ulcerative colitis; 60 Crohn's disease) and 43 healthy blood donors were included in this retrospective study in a tertiary care setting. The medical records of the patients were reviewed to note clinical activity indices, red cell distribution width, serum C ...

  3. Relationship between red cell distribution width and early renal injury in patients with gestational diabetes mellitus.

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    Cheng, Dong; Zhao, Jiangtao; Jian, Liguo; Ding, Tongbin; Liu, Shichao

    2016-09-01

    Previous studies found that red cell distribution width was related to adverse cardiovascular events. However, few studies reported the relationship between red cell distribution width and early-stage renal injury in pregnant women with gestational diabetes mellitus. Using a cross-sectional design, 334 pregnant women with gestational diabetes mellitus were enrolled according to the criterion of inclusion and exclusion. Demographic and clinical examination data were collected. Depended on the urine albumin, study population were divided into case group (n = 118) and control group (n = 216). Compared with control group, the case group tend to be higher red cell distribution width level (13.6 ± 0.9 vs.12.5 ± 0.6, p red cell distribution width was positively associated with albuminuria creatinine ratio (r = 0.567, p red cell distribution width was still associated with early-stage renal injury after adjusting for many other potential cofounders. Compared with the first quartile, the risk ratio of the second, the third and the fourth quartile were 1.38 (95%CI: 1.06-1.80), 1.57 (95%CI: 1.21-2.97), 2.71 (95%CI: 2.08-3.54), respectively. Besides, systolic blood pressure, estimated glomerular filtration rate, uric acid and blood urea nitrogen were also significantly associated with renal injury in gestational diabetes mellitus patients. The elevated red cell distribution width level might be a predictor of early-stage renal injury in pregnant women with gestational diabetes mellitus. As an easy and routine examination index, red cell distribution width may provide better clinical guidance when combined with other important indices.

  4. Evaluation of Red Blood Cell Distribution Width in Patients with Cardiac Syndrome X

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    Ping Qing

    2013-01-01

    Full Text Available BACKGROUND: Cardiac syndrome X (CSX is a condition characterized by chest pain with normal coronary arteries. However, its pathogenesis has not fully been understood yet. Red blood cell distribution width (RDW has recently been suggested as a marker of acute and chronic cardiovascular diseases, while no data is available in patients with CSX.

  5. Red blood cell distribution width and 1-year mortality in acute heart failure

    NARCIS (Netherlands)

    van Kimmenade, Roland R. J.; Mohammed, Asim A.; Uthamalingam, Shanmugam; van der Meer, Peter; Felker, G. Michael; Januzzi, James L.

    2010-01-01

    Red blood cell distribution width (RDW) predicts mortality in chronic heart failure (HF) and stable coronary artery disease. The prognostic value of RDW in more acute settings such as acute HF, and its relative prognostic value compared with more established measures such as N-terminal pro-brain nat

  6. Clinical application of whole blood red cell distribution width in lung cancer metastasis

    Institute of Scientific and Technical Information of China (English)

    徐阳飏

    2014-01-01

    Objective To investigate the clinical value of whole blood red cell distribution width(RDW)in discriminating lung cancer metastasis.Methods A retropective analysis was conducted on the patients who were initially diagnosed as primary lung cancer.A total of 525 patients were included for analysis between January 2012 and July2013,stratified by different stages and metastasis scenarios.RDW data was investigated.Kruskal-Wallis H tests

  7. The relationship between subclinic atherosclerosis and red cell distribution width in patients with metabolic syndrome

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    Ali Rıza Gülcan

    2013-12-01

    Full Text Available Objectıve: We have investigated the possible associationbetween red cell distribution width (RDW and subclinicatherosclerosis which can assessed by carotidintima-media thickness (CIMT measurement in patientswith metabolic syndrome (MetS.Methods: 74 patients with MetS were enrolled to thestudy. Patients were divided into 2 groups according tocarotid intima-media thickness (CIMT measurement: 35patients with CIMT≥1.0 mm were at group 1 and 39 patientswith CIMT<1.0 mm were at group 2. RDW weremeasured using an automated blood cell counter.Results: The RDW level was not statistically significantin patients with CIMT≥1,0 mm than in patients withCIMT<1,0 mm (13.73±0.79% vs. 13.77±1.04 %; p=0.85.Conclusion: In our study, we found that RDW was notdifferent in the MetS patients with CIMT≥1.0 mm comparedwith the MetS patients with CIMT<1.0 mm.Key words: red cell distribution width, metabolic syndrome,complete blood count

  8. Red cell distribution width in anemic patients undergoing transcatheter aortic valve implantation

    Institute of Scientific and Technical Information of China (English)

    Katharina Hellhammer; Tobias Zeus; Pablo E Verde; Verena Veulemanns; Lisa Kahlstadt; Georg Wolff; Ralf Erkens; Ralf Westenfeld; Eliano P Navarese; Marc W Merx; Tienush Rassaf; Malte Kelm

    2016-01-01

    AIM: To determine the impact of red blood cell distribution width on outcome in anemic patients undergoing transcatheter aortic valve implantation(TAVI).METHODS: In a retrospective single center cohort study we determined the impact of baseline red cell distribution width(RDW) and anemia on outcome in 376 patients with aortic stenosis undergoing TAVI. All patients were discussed in the institutional heart team and declined for surgical aortic valve replacement due to high operative risk. Collected data included patient characteristics, imaging findings, periprocedural in hospital data, laboratory results and follow up data. Blood samples for hematology and biochemistry analysis were taken from every patient before and at fixed intervals up to 72 h after TAVI including blood count and creatinine. Descriptive statistics were used for patient’s characteristics. KaplanMeier survival curves were used for time to event outcomes. A recursive partitioning regression and classification was used to investigate the association between potential risk factors and outcome variables.RESULTS: Mean age in our study population was 81 ± 6.1 years. Anemia was prevalent in 63.6%(n = 239) of our patients. Age and creatinine were identified as risk factors for anemia. In our study population, anemia per se did influence 30-d mortality but did not predict longterm mortality. In contrast, a RDW > 14% showed to be highly predictable for a reduced short- and longterm survival in patients with aortic valve disease after TAVI procedure.CONCLUSION: Age and kidney function determine the degree of anemia. The anisocytosis of red blood cells in anemic patients supplements prognostic information in addition to that derived from the WHO-based definition of anemia.

  9. [Red cell distribution width as a risk marker in patients with cardiovascular diseases].

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    Alcaíno, Hernán; Pozo, José; Pavez, Mario; Toledo, Humberto

    2016-05-01

    Red cell distribution width (RDW) is a measurement of the variation in size, as well as an index of heterogeneity of erythrocytes, which is used in combination with other hematologic parameters as an aid to the differential diagnosis of hypochromic anemia. RDW could also serve as a biomarker in the diagnosis and prognosis patients with cardiovascular diseases. However, it is unclear whether the increased heterogeneity is the cause or consequence of other pathophysiological conditions such as renal failure, malnutrition, inflammation and oxidative stress, which among other conditions are actively involved in the genesis and progression of cardiovascular diseases. The aim of this review is to show and discuss recent evidence about the role of RDW measurement as an aid in the diagnosis and prognosis of patients with such diseases. Besides being a simple, inexpensive and routinely measured parameter, it could help in the stratification of patients according to their risk in clinical practice.

  10. Predictive value of red blood cell distribution width for coronary artery lesions in patients with Kawasaki disease.

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    Xu, Haiyan; Fu, Songling; Wang, Wei; Zhang, Qing; Hu, Jian; Gao, Lichao; Zhu, Weihua; Gong, Fangqi

    2016-08-01

    Recent studies have shown that elevated red blood cell distribution width is associated with poor outcome in cardiovascular diseases. In order to assess the predictive value of red blood cell distribution width, before treatment with intravenous immunoglobulins, for coronary artery lesions in patient with Kawasaki disease, we compared 83 patients with coronary artery lesions and 339 patients without coronary artery lesions before treatment with intravenous immunoglobulin. Clinical, echocardiographic, and biochemical values were evaluated along with red blood cell distribution width. A total of 422 consecutive patients with Kawasaki disease were enrolled into our study. According to receiver operating characteristic curve analysis, the optimal red blood cell distribution width cut-off value for predicting coronary artery lesions was 14.55% (area under the curve was 0.721; p=0.000); eighty-three patients (19.7%) had coronary artery lesions, and 70% of the patients with coronary artery lesions had red blood cell distribution width level >14.55%. Logistic regression analysis revealed that fever duration >14 days (odds ratio was 3.42, 95% confidence interval was 1.27-9.22; p=0.015), intravenous immunoglobulin resistance (odds ratio was 2.33, 95% confidence interval was 1.02-5.29; p=0.04), and red blood cell distribution width >14.55% (odds ratio was 3.49, 95% confidence interval was 2.01-6.05; p=0.000) were independent predictors of coronary artery lesions in patients with Kawasaki disease. In Conclusion, red blood cell distribution width may be helpful for predicting coronary artery lesions in patients with Kawasaki disease.

  11. Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder

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    Asoglu M

    2016-09-01

    Full Text Available Mehmet Asoglu,1 Mehmet Aslan,2 Okan Imre,1 Yuksel Kivrak,3 Oznur Akil,1 Emin Savik,4 Hasan Buyukaslan,5 Ulker Fedai,1 Abdurrahman Altındag6 1Department of Psychiatry, Faculty of Medicine, Harran University, Sanliurfa, 2Department of Internal Medicine, Faculty of Medicine, Yuzuncu Yil University, Van, 3Department of Psychiatry, Faculty of Medicine, Kafkas University, Kars, 4Department of Clinical Biochemistry, Faculty of Medicine, Harran University, 5Department of Emergency Medicine, Faculty of Medicine, Harran University, Sanliurfa, 6Department of Psychiatry, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey Background: As the relationship between psychological stress and platelet activation has been widely studied in recent years, activated platelets lead to certain biochemical changes, which occur in the brain in patients with mental disorders. However, data relating to the mean platelet volume (MPV in patients with panic disorder (PD are both limited and controversial. Herein, we aimed to evaluate, for the first time, the red cell distribution width (RDW levels combined with MPV levels in patients with PD.Patients and methods: Between January 2012 and June 2015, data of 30 treatment-naïve patients (16 females, 14 males; mean age: 37±10 years; range: 18–59 years who were diagnosed with PD and 25 age- and sex-matched healthy volunteers (10 females, 15 males; mean age: 36±13 years; range: 18–59 years (control group were retrospectively analyzed. The white blood cell count (WBC, MPV, and RDW levels were measured in both groups.Results: The mean WBC, MPV, and RDW levels were 9,173.03±2,400.31/mm3, 8.19±1.13 fl, and 12.47±1.14%, respectively, in the PD group. These values were found to be 7,090.24±1,032.61, 6.85±0.67, and 11.63±0.85, respectively, in the healthy controls. The WBC, MPV, and RDW levels were significantly higher in the patients with PD compared to the healthy controls (P=0.001, P=0.001, and P=0

  12. Red blood cell distribution width and iron deficiency anemia among pregnant Sudanese women

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    Abdelrahman Esam G

    2012-12-01

    Full Text Available Abstract Background Iron deficiency anemia (IDA is a major health problem during pregnancy and it has adverse effects on the mother and the newborn. Red cell distribution width (RDW, which is a quantitative measure for red cell size variation (anisocytosis, is a predictor of IDA. Little is known regarding RDW and IDA during pregnancy. Methods A cross sectional study was conducted at the antenatal clinic of Khartoum Hospital, Sudan, to determine the performance of RDW in the diagnosis of IDA using serum ferritin as a gold standard. Results Among 194 pregnant women with a gestational period of 21.4 ± 6.5 weeks, 57 (29.4% had IDA according to serum ferritin levels (14.5. The sensitivity, specificity, positive predictive value, and negative predictive value of RDW where serum ferritin was the gold standard were 43.8% (95% CI: 31.4–57.0%, 73.7% (95% CI: 65.8–80.5%, 41.0% (95% CI: 29.2–53.6%, and 76.0% (95% CI: 68.1–82.6%, respectively. Conclusions In this study, we found that RDW has a poor performance in diagnosing IDA among pregnant women compared with serum ferritin as the gold standard. Virtual slides The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1721072967826303

  13. Variation of Red Blood Cell Distribution Width and Mean Platelet Volume after Moderate Endurance Exercise

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    Giuseppe Lippi

    2014-01-01

    Full Text Available Although physical exercise strongly influences several laboratory parameters, data about the hematological changes after medium distance running are scarce. We studied 31 middle-trained athletes (mean training regimen 217±32 min/week who performed a 21.1 km, half-marathon run. Blood samples were collected before the run, at the end, and 3 and 20 hours thereafter. The complete blood count was performed on Advia 2120 and included red blood cell (RBC, reticulocyte, and platelet counts; hemoglobin; mean corpuscular volume (MCV; mean corpuscular hemoglobin (MCH; reticulocyte haemoglobin content (Ret CHR; RBC distribution width (RDW, mean platelet volume (MPV. No significant variations were observed for MCH and Ret CHR. The RBC, reticulocyte, and hemoglobin values modestly decreased after the run. The MCV significantly increased at the end of running but returned to baseline 3 hours thereafter. The RDW constantly increased, reaching a peak 20 hours after the run. The platelet count and MPV both increased after the run and returned to baseline 3 hours thereafter. These results may have implications for definition of reference ranges and antidoping testing, and may also contribute to explaining the relationship between endurance exercise and mortality, since previous studies reported that RDW and MPV may be significantly associated with cardiovascular disease.

  14. The Evaluation of Red Cell Distribution Width in Chronic Hemodialysis Patients

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    Hikmet Tekce

    2014-01-01

    Full Text Available Background. Red cell distribution width (RDW has been used as a marker of iron deficiency; however, it is accepted as a marker of cardiovascular survival. We aimed to study RDW levels in hemodialysis (HD patients and the association between RDW and inflammatory, nutritional, and volume markers. Methods. We included 296 HD patients with sufficient iron storage and without anemia or hypervolemia. We grouped patients into four groups according to clinical parameters, albumin, and C-reactive protein (CRP. Results. The lowest RDW levels were found in group 1 (13.2%. Although RDW of group 2 was higher than that of group 1, it was still in normal range (14.7% versus 13.2%, P=0.028. RDW levels of groups 3 (17.8% and 4 (18.5% were significantly higher than those of groups 1 and 2 and above normal range. A positive correlation was detected between RDW and HD duration, interdialytic weight gain (IDWG, serum phosphate, and CRP levels and a negative correlation was detected with serum albumin. HD duration, CRP, IDWG, and serum albumin have been found as independent predictors of RDW elevation. Conclusions. Results of the present study reflect adverse effects of inflammation, malnutrition, and excess IDWG on RDW elevation in an HD study cohort with sufficient iron storage and without anemia and hypervolemia.

  15. Association of erythrocyte deformability with red blood cell distribution width in metabolic diseases and thalassemia trait.

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    Vayá, Amparo; Alis, Rafael; Suescún, Marta; Rivera, Leonor; Murado, Julian; Romagnoli, Marco; Solá, Eva; Hernandez-Mijares, Antonio

    2015-01-01

    Increased red blood distribution width (RDW) in anemia is related to disturbances in the cellular surface/volume ratio, usually accompanied by morphological alterations, while it has been shown in inflammatory diseases that the activity of pro-inflammatory cytokines disturbing erythropoiesis increases RDW. Recently it has been reported that higher RDW is related with decreased erythrocyte deformability, and that it could be related with the association of RDW and increased risk of cardiovascular diseases. In order to analyze the influence of morphological alterations and proinflammatory status on the relationship between RDW and erythrocyte deformability, we analyzed erythrocyte deformability along with RDW and other hematological and biochemical parameters in 36 α-thalassemia, 20 β-thalassemia, 20 δβ-thalassemia trait carriers, 61 metabolic syndrome patients and 76 morbidly obese patients. RDW correlated inversely with erythrocyte deformability in minor β-thalassemia (r =-0.530, p thalassemia is often accompanied by more marked cell-shaped perturbations than other thalassemia traits. This could be the reason for this negative association only in this setting. Higher anisocytosis seems to be associated with greater morphologic alterations (shape/volume), which reduce erythrocyte deformability. The proinflammatory profile in metabolic patients can be related to the positive association of RDW with erythrocyte deformability found in these patients. However, further research is needed to explain the mechanisms underlying this association.

  16. Red cell distribution width predicts totally occluded infarct-related artery in NSTEMI.

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    Açıkgöz, Sadık Kadri; Akboğa, Mehmet Kadri; Açıkgöz, Eser; Yayla, Çağrı; Şensoy, Barış; Aydoğdu, Sinan

    2016-08-01

    Objective Since non-ST segment elevation myocardial infarction (NSTEMI) patients with totally occluded infarct-related artery (TO-IRA) have worse prognosis, it is important to recognize TO-IRA in NSTEMI. Red cell distribution width (RDW) and mean platelet volume (MPV) are novel markers of inflammation and oxidative stress and were associated with poor clinical outcomes in acute coronary syndrome. In the present study, association of RDW and MPV with the presence of TO-IRA in NSTEMI was investigated. Methods Data of 201 consecutive patients who underwent coronary angiography with a diagnosis of NSTEMI were analyzed. Independent predictors of TO-IRA were investigated with logistic regression analysis. Results Sixty-six (32.8%) of the patients had TO-IRA. In patients with TO-IRA, RDW and troponin-T were significantly higher and left ventricular ejection fraction (LVEF) was lower. MPV did not differ between groups. Circumflex (CX) IRA was more common in TO-IRA group. The ROC curve analysis showed that the RDW at a cut-point of 13.95% has 76% sensitivity and 66% specificity in detecting TO-IRA. RDW, troponin-T, LVEF and CX-IRA were independent predictors of TO-IRA in NSTEMI, but MPV was not. Conclusion RDW is a cheap and readily available marker that may have a role to predict TO-IRA in NSTEMI.

  17. Ratio of spleen diameter to red blood cell distribution width: a novel indicator for celiac disease.

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    Balaban, Daniel Vasile; Popp, Alina; Lungu, Andrei Marian; Costache, Raluca Simona; Anca, Ioana Alina; Jinga, Mariana

    2015-04-01

    Celiac disease (CD) is currently considerably underdiagnosed, setting the need for developing tools to select patients with probability of CD, who warrant further testing. Red blood cell distribution width (RDW) has been shown in previous studies to be a sensitive predictor for CD, but it lacks specificity. Splenic hypotrophy is also noted frequently in celiac patients. Our aim was to evaluate if spleen diameter to RDW ratio can be used as an indicator for CD. We evaluated 15 newly diagnosed CD patients, 52 patients with inflammatory bowel disease, and 35 patients with irritable bowel syndrome (IBS). We evaluated the differences in spleen diameter, RDW, and their ratio among the four groups. Two-thirds of the CD patients had elevated RDW, compared to 9% in the IBS group. A small spleen was seen in 80% of the celiacs, compared to 21.9% in the ulcerative colitis group, 10% in the Crohn disease group, and 9% in the IBS group. A spleen diameter to RDW ratio under 6 had a sensitivity of 73.3% and specificity of 88.5% in predicting CD, with an AUROC of 0.737. Spleen diameter to RDW ratio is a simple, widely available score, which can be used to select adult patients with probability of CD.

  18. Admission red cell distribution width: a novel predictor of massive transfusion after injury.

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    Paulus, Elena M; Weinberg, Jordan A; Magnotti, Louis J; Sharpe, John P; Schroeppel, Thomas J; Fabian, Timothy C; Croce, Martin A

    2014-07-01

    Admission red cell distribution width (aRDW) has been shown to predict mortality in trauma patients by an unclear mechanism. It has been speculated that aRDW is a marker of chronic health status, but elevated RDW may also reflect recent hemorrhage. We hypothesized that aRDW is a predictor of major hemorrhage in trauma patients. Shock trauma patients at a Level I trauma center over 6.5 years were evaluated. Patients were stratified by aRDW quintile (Q1: less than 13%, Q2: 13.1 to 13.5%, Q3: 13.6 to 14.0%, Q4: 14.1 to 14.9%, Q5: 15.0% or greater). Massive transfusion (MT) was defined as 10 or more packed red blood cells in the first 24 hours. From multiple logistic regression, odds ratios with 95 per cent confidence intervals (CIs) were determined to evaluate the association between aRDW quintile and MT. Three thousand nine hundred ninety-four met study criteria. Overall MT incidence was 10 per cent and in-hospital mortality was 17 per cent. MT and mortality increased in a stepwise fashion by aRDW quintile (P < 0.0001). From logistic regression, a threefold increased odds of MT was associated with aRDW Q4 (CI, 1.81 to 4.92), and a 3.5-fold increased odds of MT was associated with aRDW Q5 (CI, 2.70 to 5.83). aRDW independently predicted MT, suggesting that elevated aRDW is an indicator of major hemorrhage in trauma patients. The association between aRDW and mortality in trauma patients may be explained by acute hemorrhage rather than chronic health status.

  19. Determinants of Red Cell Distribution Width (RDW) in Cardiorenal Patients : RDW is Not Related to Erythropoietin Resistance

    NARCIS (Netherlands)

    Emans, Mireille E.; van der Putten, Karien; van Rooijen, Karlijn L.; Kraaijenhagen, Rob J.; Swinkels, Dorine; van Solinge, Wouter W.; Cramer, Maarten J.; Doevendans, Pieter A. F. M.; Braam, Branko; Gaillard, Carlo A. J. M.

    2011-01-01

    Background: Studies have shown that red cell distribution width (RDW) is related to outcome in chronic heart failure (CHF). The pathophysiological process is unknown. We studied the relationship between RDW and erythropoietin (EPO) resistance, and related factors such as erythropoietic activity, fun

  20. Red cell distribution width as a marker of impaired exercise tolerance in patients with chronic heart failure

    NARCIS (Netherlands)

    Van Craenenbroeck, Emeline M; Pelle, A.J.M.; Beckers, Paul J; Possemiers, Nadine M; Ramakers, Christian; Vrints, Christiaan J; Van Hoof, Viviane; Denollet, J.; Conraads, Viviane M

    2012-01-01

    AIMS: Exercise intolerance predicts mortality in patients with chronic heart failure (CHF). Recently, increased red cell distribution width (RDW) has emerged as an additional powerful predictor of poor outcome. We investigated the relationship between RDW and exercise capacity in patients with CHF.

  1. Determinants of red cell distribution width (RDW) in cardiorenal patients: RDW is not related to erythropoietin resistance.

    NARCIS (Netherlands)

    Emans, M.E.; Putten, K. van der; Rooijen, K.L. van; Kraaijenhagen, R.J.; Swinkels, D.W.; Solinge, W.W. van; Cramer, M.J.; Doevendans, P.A.; Braam, B.; Gaillard, C.A.J.M.

    2011-01-01

    BACKGROUND: Studies have shown that red cell distribution width (RDW) is related to outcome in chronic heart failure (CHF). The pathophysiological process is unknown. We studied the relationship between RDW and erythropoietin (EPO) resistance, and related factors such as erythropoietic activity, fun

  2. Red cell distribution width and neurological scoring systems in acute stroke patients

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    Kara H

    2015-03-01

    Full Text Available Hasan Kara,1 Selim Degirmenci,1 Aysegul Bayir,1 Ahmet Ak,1 Murat Akinci,1 Ali Dogru,1 Fikret Akyurek,2 Seyit Ali Kayis3 1Department of Emergency Medicine, Faculty of Medicine, Selcuk University, Konya, Turkey; 2Department of Biochemistry, Faculty of Medicine, Selcuk University, Konya, Turkey; 3Department of Biostatistics, Faculty of Medicine, Karabuk University, Karabuk, Turkey Objectives: The purpose of the present study was to evaluate the association between the red blood cell distribution width (RDW and the Glasgow Coma Scale (GCS, Canadian Neurological Scale (CNS, and National Institutes of Health Stroke Scale (NIHSS scores in patients who had acute ischemic stroke. Methods: This prospective observational cohort study included 88 patients who have had acute ischemic stroke and a control group of 40 patients who were evaluated in the Emergency Department for disorders other than acute ischemic stroke. All subjects had RDW determined, and stroke patients had scoring with the GCS, CNS, and NIHSS scores. The GCS, CNS, and NIHSS scores of the patients were rated as mild, moderate, or severe and compared with RDW. Results: Stroke patients had significantly higher median RDW than control subjects. The median RDW values were significantly elevated in patients who had more severe rather than milder strokes rated with all three scoring systems (GCS, CNS, and NIHSS. The median RDW values were significantly elevated for patients who had moderate rather than mild strokes rated by GCS and CNS and for patients who had severe rather than mild strokes rated by NIHSS. The area under the receiver operating characteristic curve was 0.760 (95% confidence interval, 0.676–0.844. Separation of stroke patients and control groups was optimal with RDW 14% (sensitivity, 71.6%; specificity, 67.5%; accuracy, 70.3%. Conclusion: In stroke patients who have symptoms <24 hours, the RDW may be useful in predicting the severity and functional outcomes of the stroke

  3. Red Blood Cell Distribution Width, Hematology, and Serum Biochemistry in Dogs with Echocardiographically Estimated Precapillary and Postcapillary Pulmonary Arterial Hypertension

    OpenAIRE

    2016-01-01

    Background Red blood cell distribution width (RDW) is a quantitative measurement of anisocytosis. RDW has prognostic value in humans with different cardiovascular and systemic disorders, but few studies have investigated this biomarker in dogs. Objectives To compare the RDW in dogs with precapillary and postcapillary pulmonary hypertension (PH) and a control population of dogs and to correlate RDW with demographic, echocardiographic, and laboratory variables. Animals One hundred and twenty‐se...

  4. Red cell distribution width in relation to incidence of stroke and carotid atherosclerosis: a population-based cohort study.

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    Martin Söderholm

    Full Text Available Increased red cell distribution width (RDW has been related to poor prognosis in patients with cardiovascular disease, and is a predictor of cardiovascular mortality in the general population. The purpose of the present study was to investigate if RDW is associated with increased incidence of stroke and its subtypes in individuals from the general population.Red cell distribution width was measured in 26,879 participants (16,561 women and 10,318 men aged 45-73 years without history of coronary events or stroke, from the population-based Malmö Diet and Cancer Study. Incidences of total stroke and stroke subtypes over a mean follow-up of 15.2 years were calculated in relation to sex-specific quartiles of RDW. The presence of carotid plaque and intima-media thickness, as assessed by ultrasound, was studied in relation to RDW in a randomly selected subcohort (n = 5,309.Incidences of total stroke (n = 1,869 and cerebral infarction (n = 1,544 were both increased in individuals with high RDW. Hazard ratios (HRs in the highest compared to the lowest quartile were 1.31 for total stroke (95% confidence interval [CI]: 1.11-1.54, p for trend = 0.004 and 1.32 for cerebral infarction (95% CI: 1.10-1.58, p for trend = 0.004 after adjustment for stroke risk factors and hematological parameters. The adjusted HR for intracerebral hemorrhage (n = 230 was 1.44 (95% CI: 0.90-2.30 and the HR for subarachnoid hemorrhage (n = 75 was 0.94 (95% CI: 0.43-2.07, in the highest compared to the lowest quartile of RDW. Red cell distribution width was positively associated with intima-media thickness of the common carotid artery (p for trend = 0.011.Red cell distribution width in the highest quartile was associated with increased incidence of total stroke and cerebral infarction. There was no significant association between RDW and incidence of intracerebral or subarachnoid hemorrhage.

  5. Red blood cell distribution width is an independent predictor of mortality in patients with gram-negative bacteremia.

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    Ku, Nam Su; Kim, Hye-Won; Oh, Hyung Jung; Kim, Yong Chan; Kim, Min Hyung; Song, Je Eun; Oh, Dong Hyun; Ahn, Jin Young; Kim, Sun Bean; Jeong, Su Jin; Han, Sang Hoon; Kim, Chang Oh; Song, Young Goo; Kim, June Myung; Choi, Jun Yong

    2012-08-01

    Red blood cell distribution width (RDW) is known to be a predictor of severe morbidity and mortality in some chronic diseases such as congestive heart failure. However, to our knowledge, little is known about RDW as a predictor of mortality in patients with Gram-negative bacteremia, a major nosocomial cause of intra-abdominal infections, urinary tract infections, and primary bacteremia. Therefore, we investigated whether RDW is an independent predictor of mortality in patients with Gram-negative bacteremia. Clinical characteristics, laboratory parameters, and outcomes of 161 patients with Gram-negative bacteremia from November 2010 to March 2011 diagnosed at Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, were retrospectively analyzed. The main outcome measure was 28-day all-cause mortality. The 28-day mortality rate was significantly higher in the increased RDW group compared with the normal RDW group (P blood cell distribution width at the onset of bacteremia was an independent predictor of mortality in patients with Gram-negative bacteremia. Also, 72-h RDW could be a predictor for all-cause mortality in patients with Gram-negative bacteremia.

  6. The Prognostic Role of Red Blood Cell Distribution Width in Coronary Artery Disease: A Review of the Pathophysiology

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    Kamil Bujak

    2015-01-01

    Full Text Available Red blood cell distribution width (RDW is a measure of red blood cell volume variations (anisocytosis and is reported as part of a standard complete blood count. In recent years, numerous studies have noted the importance of RDW as a predictor of poor clinical outcomes in the settings of various diseases, including coronary artery disease (CAD. In this paper, we discuss the prognostic value of RDW in CAD and describe the pathophysiological connection between RDW and acute coronary syndrome. In our opinion, the negative prognostic effects of elevated RDW levels may be attributed to the adverse effects of independent risk factors such as inflammation, oxidative stress, and vitamin D3 and iron deficiency on bone marrow function (erythropoiesis. Elevated RDW values may reflect the intensity of these phenomena and their unfavorable impacts on bone marrow erythropoiesis. Furthermore, decreased red blood cell deformability among patients with higher RDW values impairs blood flow through the microcirculation, resulting in the diminution of oxygen supply at the tissue level, particularly among patients suffering from myocardial infarction treated with urgent revascularization.

  7. The Prognostic Role of Red Blood Cell Distribution Width in Coronary Artery Disease: A Review of the Pathophysiology

    Science.gov (United States)

    Bujak, Kamil; Wasilewski, Jarosław; Osadnik, Tadeusz; Jonczyk, Sandra; Kołodziejska, Aleksandra; Gierlotka, Marek; Gąsior, Mariusz

    2015-01-01

    Red blood cell distribution width (RDW) is a measure of red blood cell volume variations (anisocytosis) and is reported as part of a standard complete blood count. In recent years, numerous studies have noted the importance of RDW as a predictor of poor clinical outcomes in the settings of various diseases, including coronary artery disease (CAD). In this paper, we discuss the prognostic value of RDW in CAD and describe the pathophysiological connection between RDW and acute coronary syndrome. In our opinion, the negative prognostic effects of elevated RDW levels may be attributed to the adverse effects of independent risk factors such as inflammation, oxidative stress, and vitamin D3 and iron deficiency on bone marrow function (erythropoiesis). Elevated RDW values may reflect the intensity of these phenomena and their unfavorable impacts on bone marrow erythropoiesis. Furthermore, decreased red blood cell deformability among patients with higher RDW values impairs blood flow through the microcirculation, resulting in the diminution of oxygen supply at the tissue level, particularly among patients suffering from myocardial infarction treated with urgent revascularization. PMID:26379362

  8. Haematological, biochemical and inflammatory parameters in inactive Behçet's disease. Its association with red blood cell distribution width.

    Science.gov (United States)

    Vayá, Amparo; Rivera, Leonor; Todolí, José; Hernandez, Jose Luis; Laiz, Begoña; Ricart, José M

    2014-01-01

    Red blood cell distribution width (RDW) has been shown to be associated with disease activity in several inflammatory disorders. However only one study to show this has been conducted in patients with Behçet's disease (BD). The aim of the present study was to analyse the association of RDW with BD and its main complications; i.e.; thrombosis and posterior uveitis. A second aim was to analyse the possible correlation between RDW and both haematological and inflammatory parameters. Eighty-nine patients with BD (48 males/41 females) and 94 controls (49 males/45 females) were included in the study. Patients were in an inactive phase of the disease, showing only minimum activity. RDW was statistically higher in patients than in controls (14.02 ± 1.32 vs. 13.15 ± 0.75; p 0.05). RDW correlated negatively with haemoglobin, MCH and MCHC (p 0.05). The multivariate regression analysis revealed that haemoglobin and homocysteine were independent predictors of RDW (beta coefficient: -0.310; p = 0.003, beta coefficient: 0.379; p 14 was associated with neither thrombosis nor uveitis (p = 0.935; p = 0.553, respectively). Our results indicate that BD patients show increased RDW when compared with controls. This increase seems to be related with haematimetric indices and with homocysteine levels. Lack of correlation with inflammatory markers may be due to the fact that patients were in an inactive phase of the disease.

  9. Increased red blood cell distribution width associates with cancer stage and prognosis in patients with lung cancer.

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    Yasuko Koma

    Full Text Available BACKGROUND: Red cell distribution width (RDW, one of many routinely examined parameters, shows the heterogeneity in erythrocyte size. We investigated the association of RDW levels with clinical parameters and prognosis of lung cancer patients. METHODS: Clinical and laboratory data from 332 patients with lung cancer in a single institution were retrospectively studied by univariate analysis. Kaplan-Meier survival analysis and Cox proportional hazard models were used to examine the effect of RDW on survival. RESULTS: THE RDW LEVELS WERE DIVIDED INTO TWO GROUPS: high RDW (>=15%, n=73 vs. low RDW, n=259 (<15%. Univariate analysis showed that there were significant associations of high RDW values with cancer stage, performance status, presence of other disease, white blood cell count, hemoglobin, mean corpuscular volume, platelet count, albumin level, C-reactive protein level, and cytokeratin 19 fragment level. Kruskal-Wallis tests revealed an association of RDW values with cancer stage in patients irrespective of comorbidity (patient with/without comorbidity: p<0.0001, patient without comorbidity: p<0.0001. Stages I-IV lung cancer patients with higher RDW values had poorer prognoses than those with lower RDW values (Wilcoxon test: p=0.002. In particular, the survival rates of stage I and II patients (n=141 were lower in the high RDW group (n=19 than in the low RDW group (n=122 (Wilcoxon test: p<0.001. Moreover, multivariate analysis showed higher RDW is a significant prognostic factor (p=0.040. CONCLUSION: RDW is associated with several factors that reflect inflammation and malnutrition in lung cancer patients. Moreover, high levels of RDW are associated with poor survival. RDW might be used as a new and convenient marker to determine a patient's general condition and to predict the mortality risk of lung cancer patients.

  10. An overall and dose-response meta-analysis of red blood cell distribution width and CVD outcomes.

    Science.gov (United States)

    Hou, Haifeng; Sun, Tao; Li, Cheng; Li, Yuanmin; Guo, Zheng; Wang, Wei; Li, Dong

    2017-02-24

    Red blood cell distribution width (RDW) is the coefficient of variation of red blood cell size, considered to be associated with cardiovascular disease (CVD). This study aimed to comprehensively synthesize previous studies on RDW and CVD outcomes through an overall and dose-response meta-analysis. PubMed, Embase and Web of Science were searched systematically for English and Chinese language publications up to November 30, 2015. We extracted data from publications matching our inclusion criteria for calculating pooled hazard ratio (HR), which was used to assess prognostic impact of RDW on CVD. Twenty-seven articles, consisting of 28 studies and 102,689 participants (mean age 63.9 years, 63,703 males/36,846 females, 2,140 gender-unmentioned subjects) were included in the present meta-analysis. The pooled HRs are 1.12 (95% CI = 1.09-1.15) for the association of all-cause mortality (ACM) per 1% increase of RDW, 1.12(95% CI = 1.08-1.17) for major adverse cardiac events (MACEs) per 1% increase of RDW. A dose-response curve relating RDW increase to its effect on CVD outcomes was established (pcurve < 0.001). For every 1-unit increase of RDW, there is an increased risk of occurrence of ACM (pooled HR = 1.03, 95% CI = 1.02-1.04) and MACEs (pooled HR = 1.04, 95% CI = 1.01-1.06). This study indicates RDW may be a prognostic indicator for CVD outcomes.

  11. Red Blood Cell Distribution Width and the Platelet Count in Iron-deficient Children Aged 0.5-3 Years.

    Science.gov (United States)

    Akkermans, M D; Uijterschout, L; Vloemans, J; Teunisse, P P; Hudig, F; Bubbers, S; Verbruggen, S; Veldhorst, M; de Leeuw, T G; van Goudoever, J B; Brus, F

    2015-01-01

    Early detection of iron deficiency (ID) and iron deficiency anemia (IDA) in young children is important to prevent impaired neurodevelopment. Unfortunately, many biomarkers of ID are influenced by infection, thus limiting their usefulness. The aim of this study was to investigate the value of red blood cell distribution width (RDW) and the platelet count for detecting ID(A) among otherwise healthy children. A multicenter prospective observational study was conducted in the Netherlands to investigate the prevalence of ID(A) in 400 healthy children aged 0.5-3 years. ID was defined as serum ferritin (SF) count were determined in the complete blood cell count. RDW was inversely correlated with SF and not associated with CRP. Calculated cutoff values for RDW to detect ID and IDA gave a relatively low sensitivity (53.1% and 57.1%, respectively) and specificity (64.7% and 69.9%, respectively). Anemic children with a RDW >14.3% had a 2.7 higher odds (95% confidence interval [CI]: 1.2-6.3) to be iron deficient, compared with anemic children with a RDW count showed a large range in both ID and non-ID children. In conclusion, RDW can be helpful for identifying ID as the cause of anemia in 0.5- to 3-year-old children, but not as primary biomarker of ID(A). RDW values are not influenced by the presence of infection. There appears to be no role for the platelet count in diagnosing ID(A) in this group of children.

  12. An overall and dose-response meta-analysis of red blood cell distribution width and CVD outcomes

    Science.gov (United States)

    Hou, Haifeng; Sun, Tao; Li, Cheng; Li, Yuanmin; Guo, Zheng; Wang, Wei; Li, Dong

    2017-01-01

    Red blood cell distribution width (RDW) is the coefficient of variation of red blood cell size, considered to be associated with cardiovascular disease (CVD). This study aimed to comprehensively synthesize previous studies on RDW and CVD outcomes through an overall and dose-response meta-analysis. PubMed, Embase and Web of Science were searched systematically for English and Chinese language publications up to November 30, 2015. We extracted data from publications matching our inclusion criteria for calculating pooled hazard ratio (HR), which was used to assess prognostic impact of RDW on CVD. Twenty-seven articles, consisting of 28 studies and 102,689 participants (mean age 63.9 years, 63,703 males/36,846 females, 2,140 gender-unmentioned subjects) were included in the present meta-analysis. The pooled HRs are 1.12 (95% CI = 1.09–1.15) for the association of all-cause mortality (ACM) per 1% increase of RDW, 1.12(95% CI = 1.08–1.17) for major adverse cardiac events (MACEs) per 1% increase of RDW. A dose-response curve relating RDW increase to its effect on CVD outcomes was established (pcurve ACM (pooled HR = 1.03, 95% CI = 1.02–1.04) and MACEs (pooled HR = 1.04, 95% CI = 1.01–1.06). This study indicates RDW may be a prognostic indicator for CVD outcomes. PMID:28233844

  13. The clinical significance of changes in red blood cell distribution width in patients with community-acquired pneumonia

    Science.gov (United States)

    Lee, Sang-Min; Lee, Jae Hyuk; Kim, Kyuseok; Jo, You Hwan; Lee, Jungyoup; Kim, Joonghee; Hwang, Ji Eun; Ko, Young Sang; Ha, Chulmin; Jang, Sujin; Park, Hyunmi

    2016-01-01

    Objective Red cell distribution width (RDW) is associated with mortality in patients with community-acquired pneumonia (CAP). However, little is known about the effect of changes in RDW during treatment on mortality. Thus, the objective of this study was to evaluate the association between RDW changes and mortality in hospitalized patients with CAP. Methods Retrospective analyses were performed using medical records of patients hospitalized for CAP from April 2008 to February 2014. The abstracted laboratory values included RDW (from days one to four), clinical variables, and pneumonia severity index (PSI) scores. The ΔRDWn-1 was defined as the change in RDW calculated as: (RDWday1-RDWday-n)/RDWday1×100 (%), where ‘day n’ refers to hospital day. Results During the study period, a total of 1,069 patients were hospitalized for CAP. The 30-day mortality was 100/1,069 (9.4%). The median RDW at baseline was 14.1% (range, 11.1 to 30.2) and differed significantly between survivors and non-survivors (P<0.05). There were 470 patients with available serial RDW data (30-day mortality 58/470 [12.3%]). Of those, age, PSI score, blood urea nitrogen level, total protein concentration, albumin level, RDW at day 1, and the ΔRDW4-1 differed significantly between survivors and non-survivors. Multivariate Cox regression analysis showed that the significance of the relationship between ΔRDW4-1 and 30-day mortality risk remained after adjusting for age, PSI score, RDW at day 1, total protein concentration, and initial albumin level. Conclusion RDW change from day 1 to day 4 was an independent predictor of mortality in patients with CAP.

  14. COMPARISON OF RED CELL DISTRIBUTION WIDTH WITH SOFA SCORE AS A PROGNOSTIC MARKER OF SEPSIS IN ELDERLY PATIENTS

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    Shaikh Mohammed Aslam

    2015-12-01

    Full Text Available BACKGROUND Severe sepsis and septic shock are increasing in incidence and contributing significantly to mortality. The prediction of outcome for elderly patients with sepsis may facilitate more aggressive interventions. The SOFA score is a scoring system used to quantify the severity of the patient’s illness based on the degree of organ dysfunction. Various biomarkers are being evaluated for early diagnosis of sepsis. RDW is one of them, which have been shown to predict mortality and morbidity of sepsis. Hence, this study is being done to compare RDW with SOFA score as prognostic marker of sepsis in elderly patients. AIM To compare red cell distribution width with SOFA score as a prognostic marker of sepsis in elderly patients. METHODS A total of 93 elderly patients in sepsis who were admitted to Intensive Care Unit of M. S. Ramaiah Hospitals between October 2013 and September 2015 were included in the study. ROC (Receiver Operating Curve was used to determine the optimal cut-off point for RDW for predicting mortality. ROC of RDW was compared with ROC of SOFA score. RESULTS Mean age of the patients was 70.72±8.02 and most of the patients were in the age group of 61–70yrs. (53.8%. 52(55.9% patients were males and 41(44.1% patients were females. Bronchopneumonia (34.4% and urosepsis (30.1% were the most common causes of sepsis; 61.3% of the patients had SOFA score in the range of 5–10. Mean SOFA score was 7.87097±3.22769. Mean RDW was 14.247±2.1151. CONCLUSION RDW had a sensitivity of 81.6%, specificity of 77.3%, positive predictive value of 80%, and negative predictive value of 79.1% with a cut-off value of 13.75% in predicting mortality in elderly patients in sepsis.

  15. The predictive value of mean platelet volume, plateletcrit and red cell distribution width in the differentiation of autoimmune gastritis patients with and without type I gastric carcinoid tumors.

    Science.gov (United States)

    Tüzün, Ali; Keskin, Onur; Yakut, Mustafa; Kalkan, Cagdas; Soykan, Irfan

    2014-01-01

    Autoimmune gastritis is an autoimmune and inflammatory condition that may predispose to gastric carcinoid tumors or adenocarcinomas. The early diagnosis of these tumors is important in order to decrease morbidity and mortality. Platelet indices such as mean platelet volume and plateletcrit levels increase in inflammatory, infectious and malign conditions. The primary aim of this study was to explore wheter platelet indices and red cell distribution width have any predictive role in the discrimination of autoimmune gastritis patients with and without gastric carcinoid tumors. Also secondary aim of this study was to investigate whether any changes exist betwenn autoimmune gastritis and functional dyspepsia patients by means of platelet indices. Plateletcrit (0.22 ± 0.06 vs. 0.20 ± 0.03%, p gastritis patients compared to control group. Receiver operating curve analysis suggested that optimum plateletcrit cut-off point was 0.20% (AUC: 0.646), and 13.95% as the cut off value for red cell distribution width (AUC: 0.860). Although plateletcrit (0.22 ± 0.06 vs. 0.21 ± 0.04%, p = 0.220) and mean platelet volume (8.94 ± 1.44 vs. 8.68 ± 0.89 fl, p = 0.265) were higher in autoimmune gastritis patients without carcinoid tumor compared to patients with carcinoid tumors, these parameters were not statistically significant. Changes in plateletcrit and red cell distribution width values may be used as a marker in the discrimination of autoimmune gastritis and fucntional dyspepsia patients but not useful in patients with gastric carcinoid tumor type I.

  16. Width Distributions for Convex Regular Polyhedra

    CERN Document Server

    Finch, Steven R

    2011-01-01

    The mean width is a measure on three-dimensional convex bodies that enjoys equal status with volume and surface area [Rota]. As the phrase suggests, it is the mean of a probability density f. We verify formulas for mean widths of the regular tetrahedron and the cube. Higher-order moments of f_tetra and f_cube have not been examined until now. Assume that each polyhedron has edges of unit length. We deduce that the mean square width of the regular tetrahedron is 1/3+(3+sqrt(3))/(3*pi) and the mean square width of the cube is 1+4/pi.

  17. Red cell distribution width and other red blood cell parameters in patients with cancer: association with risk of venous thromboembolism and mortality.

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    Julia Riedl

    Full Text Available Cancer patients are at high risk of developing venous thromboembolism (VTE. Red cell distribution width (RDW has been reported to be associated with arterial and venous thrombosis and mortality in several diseases. Here, we analyzed the association between RDW and other red blood cell (RBC parameters with risk of VTE and mortality in patients with cancer.RBC parameters were measured in 1840 patients with cancers of the brain, breast, lung, stomach, colon, pancreas, prostate, kidney; lymphoma, multiple myeloma and other tumor sites, that were included in the Vienna Cancer and Thrombosis Study (CATS, which is an ongoing prospective, observational cohort study of patients with newly diagnosed or progressive cancer after remission. Primary study outcome is occurrence of symptomatic VTE and secondary outcome is death during a maximum follow-up of 2 years.During a median follow-up of 706 days, 131 (7.1% patients developed VTE and 702 (38.2% died. High RDW (>16% was not associated with a higher risk of VTE in the total study cohort; in competing risk analysis accounting for death as competing variable the univariable subhazard ratio (SHR was 1.34 (95% confidence interval [CI]: 0.80-2.23, p = 0.269. There was also no significant association between other RBC parameters and risk of VTE. High RDW was associated with an increased risk of mortality in the total study population (hazard ratio [HR, 95% CI]: 1.72 [1.39-2.12], p<0.001, and this association prevailed after adjustment for age, sex, hemoglobin, leukocyte and platelet count (HR [95% CI]: 1.34 [1.06-1.70], p = 0.016.RDW and other RBC parameters were not independently associated with risk of VTE in patients with cancer and might therefore not be of added value for estimating risk of VTE in patients with cancer. We could confirm that high RDW is an independent predictor of poor overall survival in cancer.

  18. Preoperative red cell distribution width and neutrophil-to-lymphocyte ratio predict survival in patients with epithelial ovarian cancer

    Science.gov (United States)

    Li, Zheng; Hong, Na; Robertson, Melissa; Wang, Chen; Jiang, Guoqian

    2017-01-01

    Several parameters of preoperative complete blood count (CBC) and inflammation-associated blood cell markers derived from them have been reported to correlate with prognosis in patients with epithelial ovarian cancer (EOC), but their prognostic importance and optimal cutoffs are still needed be elucidated. Clinic/pathological parameters, 5-year follow-up data and preoperative CBC parameters were obtained retrospectively in 654 EOC patients underwent primary surgery at Mayo Clinic. Cutoffs for neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) were optimized by receiver operating characteristic (ROC) curve. Prognostic significance for overall survival (OS) and recurrence free survival (RFS) were determined by Cox proportional hazards models and Kaplan-Meier method. Associations of RDW and NLR with clinic/pathological parameters were analyzed using non-parametric tests. RDW with cutoff 14.5 and NLR with cutoff 5.25 had independent prognostic significance for OS, while combined RDW and NLR scores stratified patients into low (RDW-low and NLR-low), intermediate (RDW-high or NLR-high) and high risk (RDW-high and NLR-high) groups, especially in patients with high-grade serous ovarian cancer (HGSOC). Moreover, high NLR was associated with poor RFS as well. Elevated RDW was strongly associated with age, whereas high NLR was strongly associated with stage, preoperative CA125 level and ascites at surgery. PMID:28223716

  19. 红细胞分布宽度的临床应用新进展%Progress in Clinical Application of Red Blood Cell Distribution Width

    Institute of Scientific and Technical Information of China (English)

    何磊

    2013-01-01

    Red blood cell distribution width( RDW )is a coefficient of variation reflecting the change of the red blood cell volume,which was mostly often used in the diagnosis and differentiation of different types of anemia. In recent years the study found that RDW has a certain clinical value in the occurrence and prognosis judgment of the disease and predicting prognosis in acute and chronic heart failure, coronary atherosclerosis heart disease,hypertension,type 2 diabetes,etc..%红细胞分布宽度(RDW)是反映周围血红细胞体积大小变化的变异性系数,既往多用于对不同类型贫血的诊断以及鉴别诊断.近年来研究发现,RDW在急、慢性心功能不全、冠状动脉粥样硬化性心脏病、高血压病、2型糖尿病等疾病的发生发展、病变严重程度、并发症的发生以及判断预后等方面具有一定的临床价值.

  20. The Acute Effect of the Antioxidant Drug U-74389G on Red Blood Cell Distribution Width Levels During Hypoxia Reoxygenation Injury in Rats

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    Tsompos Constantinos

    2015-12-01

    Full Text Available The AIM of this experimental study was to evaluate the effect of the antioxidant drug “U-74389G” in a rat model of hypoxia reoxygenation (HR using the previously established protocol. Effects of treatment were evaluated by mean red blood cell distribution width (RDW levels. MATERIALS AND METHODS: 40 rats of a mean weight of 231.875 g were employed in the study. RDW levels were determined at 60 min (groups A and C and at 120 min (groups B and D after starting the reoxygenation. Groups A and B received no drugs, whereas rats from groups C and D were administered with U-74389G. RESULTS: demonstrated that U-74389G administration significantly decreased the RDW levels by 4.96% + 2.27% (p = 0.0175. Reoxygenation time non-significantly decreased the RDW levels by 0.27% + 2.41% (p = 0.8889. Together, U-74389G administration and reoxygenation time non-significantly decreased the RDW levels by 2.54% + 1.39% (p = 0.0679. CONCLUSIONS: U-74389G administration particulary in concert without reperfusion declines the RDW levels even within the short - time context of 1.5 hours reperfusion.

  1. Preoperative red cell distribution width: Not a useful prognostic indicator for 30-day mortality in patients who undergo major- or ultra-major noncardiac surgery

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    Yik-Nang Cheung

    2016-01-01

    Full Text Available Background: Red cell distribution width (RDW has been shown to be associated with mortality in cardiac surgical patients. This study investigates the association of RDW with the 30-day mortality for those patients who undergo major- or ultra-major noncardiac surgery. Methods: Patients who received major- or ultra-major noncardiac surgery between July 2012 and May 2013 were included in the study and patients those with preoperative hemoglobin 13.35% (P = 0.025, odds ratio [OR]: 1.52, INR (P = 0.008, OR: 4.49, albumin level (P < 0.001, OR: 1.10, use of antihypertensives (P = 0.001, OR: 1.82, and preoperative pulse rate (P = 0.006, OR: 1.02 independently predicted the 30-day mortality. However, the area under receiver operating characteristic curve for the prediction of 30-day mortality using RDW was only 0.614. Conclusions: Although preoperative RDW independently predicted 30-day mortality in patients who underwent major- or ultra-major noncardiac surgery, it may not serve as an influential prognostic indicator in view of its low sensitivity and specificity.

  2. Red blood cell distribution width independently predicts medium-term mortality and major adverse cardiac events after an acute coronary syndrome

    Science.gov (United States)

    Turcato, Gianni; Serafini, Valentina; Dilda, Alice; Bovo, Chiara; Caruso, Beatrice; Ricci, Giorgio

    2016-01-01

    Background The value of red blood cell distribution width (RDW), a simple and inexpensive measure of anisocytosis, has been associated with the outcome of many human chronic disorders. Therefore, this retrospective study was aimed to investigate whether RDW may be associated with medium-term mortality and major adverse cardiac events (MACE) after an acute coronary syndrome (ACS). Methods A total number of 979 patients diagnosed with ACS were enrolled from June 2014 to November 2014, and followed-up until June 2015. Results The RDW value in patients with 3-month MACE and in those who died was significantly higher than that of patients without 3-month MACE (13.3% vs. 14.0%; P14.8% exhibited a significantly short survival than those with RDW ≤14.8% (331 vs. 465 days; P<0.001). Conclusions The results of this study confirm that RDW may be a valuable, easy and inexpensive parameter for stratifying the medium-term risk in patients with ACS. PMID:27500155

  3. Statistical study of the pulse width distribution for radio pulsars

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Pulse widths of standard pulse profiles for 262 pulsars were measured by using the Urumqi 25 m radio telescope at 1.54 GHz.For the simplest case of circular emission beam,we applied Monte Carlo simulations to the pulse width distribution.Different density functions of magnetic inclination angle α and observer angle ξ were considered.Using Kolmogorov-Smirnov tests,we derived the most probable distribution for α and ξ.

  4. The Value of Erythrocyte Indices and Red Cell Volume Distribution Width in Differential Diagnosis of Iron Deficiency Anemia and Anemia of Chronic Disease

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    Abdullah Altıntaş

    2007-01-01

    Full Text Available Iron deficiency anemia (IDA and anemia of chronic disease are the most commonly confused anemias. We investigate the diagnostic value of erythrocyte indices, red cell volume distribution width, and serum ferritin levels to make differential diagnosis of anemia in controls and anemic patients.Iron deficiency anemia (44 patients, anemia of chronic disease (41, IDA with anemia of chronic disease (17 and control (50 groups were compared. We performed serum ferritin, CBC, and sedimentation rate in all patientsand bone marrow aspiration in patients with anemia of chronic disease.Although mean cell volume (MCV and mean corpuscular hemoglobin (MCH are low in IDA and anemia of chronic disease, it is much striking in the former one (p<0.001, p<0.001. Only 7.3% of patients with anemia of chronic disease had a MCV<70 fL and MCH<24 pg, 90.0% of patients with IDA were below that cut-off point. Serum ferritin means were in patients with IDA and anemia of chronic disease were 4.6±3.3 and 489.6 ±519.9 ng/ml, respectively.The probability of IDA is low when RDW is normal in microcytic anemias. RDW is high in half of patients with anemia of chronic disease. Reference values for ferritin must be changed in patients with anemia of chronic disease and IDA. If serum ferritin is 57.6-146.4 ng/ml anemia of chronic disease and iron deficiency must ruled out by other diagnostic tests.

  5. Prognostic value of red blood cell distribution width for patients with heart failure: a systematic review and meta-analysis of cohort studies.

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    Yuan-Lan Huang

    Full Text Available AIMS: Multiple studies have investigated the prognostic role of red blood cell distribution width (RDW for patients with heart failure (HF, but the results have been inconsistent. The aim of the present study was to estimate the impact of RDW on the prognosis of HF by performing a systematic review and meta-analysis. METHODS AND RESULTS: The Embase, PubMed, and Web of Science databases were searched up to November 16, 2013 to identify eligible cohort studies. The quality of each study was assessed using the Newcastle-Ottawa Scale (NOS. The association between RDW, either on admission or at discharge, and HF outcomes (all-cause mortality [ACM], heart transplantation, cardiovascular mortality, and rehospitalization, etc. were reviewed. The overall hazard ratio (HR for the effect of RDW on ACM was pooled using a random-effects model, and the publication bias was evaluated using funnel plots and Eggers' tests. Seventeen studies, with a total of 18288 HF patients, were included for systematic review. All eligible studies indicated that RDW on admission and RDW at discharge, as well as its change during treatment, were of prognostic significance for HF patients. The HR for the effect of a 1% increase in baseline RDW on ACM was 1.10 (95% confidence interval: 1.07-1.13, based on pooling of nine studies that provided related data. However, publication bias was observed among these studies. CONCLUSIONS: HF patients with higher RDW may have poorer prognosis than those with lower RDW. Further studies are needed to explore the potential mechanisms underlying this association.

  6. Relation between Red Cell Distribution Width and Fibroblast Growth Factor 23 Cleaving in Patients with Chronic Kidney Disease and Heart Failure.

    Directory of Open Access Journals (Sweden)

    Fenna van Breda

    Full Text Available In chronic kidney disease (CKD, both anemia and deregulated phosphate metabolism are common and predictive of adverse outcome. Previous studies suggest that iron status influences phosphate metabolism by modulating proteolytic cleavage of FGF23 into C-terminal fragments. Red cell distribution width (RDW was recently identified as a strong prognostic determinant for cardiovascular morbidity and mortality, independently of iron status. We assessed whether RDW is associated with FGF23 cleaving in CKD patients with heart failure.The associations between RDW and either intact FGF23 (iFGF23, C-terminal FGF23 (cFGF23, reflecting iFGF23 and C-terminal fragments together and the iFGF23/cFGF23 ratio were analyzed in 52 patients with CKD (eGFR 34,9 ± 13.9 ml/min/1.73m2 and chronic heart failure (CHF. Associations between RDW and FGF23 forms were studied by linear regression analysis adjusted for parameters of renal function, iron metabolism, phosphate metabolism and inflammation.Median cFGF23 levels were 197.5 [110-408.5] RU/ml, median iFGF23 levels were 107.3 [65.1-162.2] pg/ml and median FGF23 ratio was 0.80 [0.37-0.86]. Mean RDW was 14.1 ± 1.2%. cFGF23 and RDW were associated (β = 1.63 x 10(-3, P < 0.001, whereas iFGF23 and RDW were not (β = -1.38 x 10(-3, P = 0.336. The iFGF23/cFGF23 ratio was inversely associated with RDW. The difference between cFGF23 and iFGF23 (cFGF23- iFGF23 was positively associated with RDW (β = 1.74 x 10(-3, P < 0.001. The association between cFGF23 and RDW persisted upon multivariable linear regression analysis, adjusted for parameters of renal function, phosphate metabolism, iron metabolism and inflammation (β = 0.97 x 10(-3, P = 0.047.RDW is associated with cFGF23 but not with iFGF23 levels in patients with CKD and CHF. This suggests a connection between RDW and FGF23 catabolism, independent of iron status and inflammation. Future studies are needed to unravel underlying mechanisms and whether these pertain to the link

  7. Red Blood Cell Distribution Width (RDW in thorougbred horses from 12 to 24 months of age/ Valores da amplitude de distribuição do tamanho dos eritrócitos (RDW – Red Cell Distribution Width em equinos da raça puro sangue inglês (PSI de ambos os sexos de 12 a 24 meses de idade

    Directory of Open Access Journals (Sweden)

    Raimundo Souza Lopes

    2001-05-01

    Full Text Available The purpose of this study was to establish reference values for red blood cell distribution width (RDW in health horses. We obtained blood samples through jugular punctured from 90 clinicaly health thorougbred horses between 12 and 24 months of age. Blood was obtained in a Cell-Dyn 3500 (Abbott Diagnostic cell counter. Mean ± standart deviation values for RDW in male horses were 26,90 ± 1,41, whereas in females values were 26,89 ± 1,75. There were no differences in the RDW values between sexes, therefore, our reference values can be used in both males and females.O objetivo do presente estudo foi estabelecer valores da amplitude de distribuição do tamanho dos eritrócitos (RDW em eqüinos clinicamente sadios. Foram utilizadas 90 amostras de sangue de eqüinos da raça Puro Sangue Inglês (PSI, clinicamente sadios de 12 a 24 meses de idade, obtidas por venipunção jugular em tubos à vácuo contendo EDTA 10%. Posteriormente as amostras foram processadas no contador automático de células Cell-Dyn 3500 (Abbott Diagnostic. Os valores médios e o desvios-padrão para o RDW (% de machos foi de 26,90 ± 1,41 e para as fêmeas de 26,89 ± 1,75. Os resultados demonstram não haver diferenças nos valores de RDW para machos e fêmeas, podendo ser utilizados como referência para ambos os sexos.

  8. 红细胞体积分布宽度与心血管疾病的研究进展%Progress in red blood cell distribution width and cardiovascular diseases

    Institute of Scientific and Technical Information of China (English)

    陈渠通; 朱辰; 吴晓虹

    2015-01-01

    Red blood cell distribution width (RDW) is a classic index for hematological disease differential diagnosis. Recently, accumulated studies have found that RDW was closely associated with the incidence, diagnosis and prognosis of various cardiovascular diseases. In present review, the relationships between RDW and heart failure, acute myocardial infarction etc. were summarized.%红细胞体积分布宽度(red blood cell distribution width,RDW)是血液系统疾病鉴别诊断的经典指标.近年来越来越多的研究发现RDW与心血管疾病的发生、诊断和预后密切相关.本文对近年来有关RDW与心力衰竭、急性心肌梗死等心血管疾病的研究进行简综述.

  9. Narrowing of Terrace-width Distributions During Growth on Vicinals

    Science.gov (United States)

    Hamouda, Ajmi Bh.; Pimpinelli, A.; Einstein, T. L.

    2009-03-01

    Using kinetic Monte Carlo simulations for a generic minimal SOS model of vicinal surfaces, we compute the terrace-width distributions (TWDs) as a function of incident flux during homoepitaxial growth. We show that the distribution narrows markedly, U.B.P.-Clermont 2 as though there were a flux-dependent repulsion between steps, until the step picture fails at high flux. Using a Fokker-Planck approach, we analyze the evolution and saturation of this narrowing. We compare with a 1D model and with our simulations for narrowing due to an Ehrlich-Schwoebel barrier.

  10. Magnetohydrodynamic disc winds and line width distributions - II

    Science.gov (United States)

    Chajet, L. S.; Hall, P. B.

    2017-02-01

    We study AGN emission line profiles combining an improved version of the accretion disc-wind model of Murray & Chiang with the magnetohydrodynamic (MHD) model of Emmering et al. Here, we extend our previous work to consider central objects with different masses and/or luminosities. We have compared the dispersions in our model C IV line-width distributions to observational upper limit on that dispersion, considering both smooth and clumpy torus models. Following Fine et al., we transform that scatter in the profile line-widths into a constraint on the torus geometry and show how the half-opening angle of the obscuring structure depends on the mass of the central object and the accretion rate. We find that the results depend only mildly on the dimensionless angular momentum, one of the two integrals of motion that characterize the dynamics of the self-similar ideal MHD outflows.

  11. TO EVALUATE ANAEMIA BY ERYTHROCYTE INDICES, RED CELL DISTRIBUTION WIDTH AND HAEMOGLOBIN ELECTROPHORESIS WITH SPECIAL REFERENCE TO THALASSEMIA IN PAEDIATRIC AGE GROUP

    Directory of Open Access Journals (Sweden)

    Mahendra

    2015-02-01

    Full Text Available Anemia is not a diagnosis; it is a manifestation of an underlying disorder. Thus, even mild, asymptomatic anemia should be investigated so that the primary problem can be diagnosed and treated. Laboratory evaluation begins with a CBC, including WBC and platelet counts, RBC indices and morphology (MCV, MCH, MCHC, RBC distribution width [RDW], and examination of the peripheral smear. In many instances routine test like Hb, TLC, DLC, GBP fail to decide anemia especially in early cases and also fail to decide the type of anaemia. In such situations the RBC indices and RDW are very useful. These become abnormal even before changes in routine hemogram are appreciable. Thalassemia minor poses problems in diagnosis because GBP reveals no features of hemolysis rather it has microcytic hypochromic picture which has similarity with iron deficiency anemia. It is difficult to differentiate between two by only GBP. Several decision making rules have been proposed for differentiation. METHOD : The present study was carried out in 100 cases to evaluate anaemia in different age groups based on RBC Indices and RDW and t o evaluate sensitivity of RBC indices and RDW in diagnosis of anaemia. Cases showing positivity by various rules and RDW in favour of thalassemia minor were subjected to Hb electrophoresis for confirmation of diagnosis. RESULTS : RBC indices are more sensitive for diagnosis of microcytic hypochromic anemia, normocytic normochromic anemia and macrocytic anemia than PBS alone. RDW - CV is superior to all in use to differentiate iron deficiency anemia an d thalassemia minor having high sensitivity 87.3% and specificity 90 .5%.

  12. Correlation of red cell distribution width with the severity of coronary artery disease: a large Chinese cohort study from a single center

    Institute of Scientific and Technical Information of China (English)

    MA Feng-lian; LI Sha; LI Xiao-lin; LIU Jun; QING Ping; GUO Yuan-lin; XU Rui-xia

    2013-01-01

    Background It has been reported that increased red blood cell width (RDW) is a marker associated with the presence and adverse outcomes of various cardiovascular diseases.The aim of the present study was prospectively evaluate the severity of coronary artery disease (CAD) and RDW in a large Chinese cohort.Methods A total of 677 consecutive individuals who underwent coronary angiography due to the presence of angina-like chest pain and/or positive treadmill exercise test were enrolled in this study.All patients received coronary angiography and were then divided into two groups based on the results of coronary angiography (CAD group (n=499) and control group (n=178)).The clinical information including classical CAD risk factors and RDW were analyzed to identify their relationship to CAD.The severity of CAD was evaluated by Gensini score and its relationship with RDW was also analyzed.Results Patients with angiographic CAD had significantly elevated RDW levels compared with controls ((12.95±0.77)%vs.(12.73±0.83)%,P=0.001).There was a significant positive correlation between RDW and the Gensini score (r=0.37,P <0.001).In multivariate Logistic regression analysis,RDW was demonstrated to be an independent predictor for both angiographic CAD (OR=1.34,95% CI.1.02-1.77,P <0.05) and for a higher Gensini score (>13,OR=2.23,95% CI.1.62-3.08,P <0.001).In a receiver operating characteristic (ROC) curve analysis,an RDW value of 12.85% was identified as an effective cut-point in predicting the presence or absence of CAD with a sensitivity of 50.0% and a specificity of 65.2%.Conclusion RDW is associated with both presence of CAD and the severity of coronary stenosis,suggesting that it might be a readily available marker for the prediction of CAD and its severity.

  13. 红细胞分布宽度在急性冠状动脉综合征中的研究进展%Research Progress of Red Blood Cell Distribution Width on Acute Coronary Syndrome

    Institute of Scientific and Technical Information of China (English)

    潘崇(综述); 李佳(审校)

    2016-01-01

    As a parameter routinely measured by most modern hematology analyzers ,red blood cell distribution width ( RDW) reflects variability in the size of circulating red blood cells .Increasing RDW is an indicator for the adverse prognosis of acute coronary syndrome and can be an independent predictor for the prognosis of cardiovascular disease .The aim of this review is to describe the prognostic utility of RDW in patients with acute coronary syndromes and to elucidate the mechanism and clinical application underlying the relationship between elevat -ed RDW values and poor patient prognosis .%红细胞分布宽度( red blood cell distribution width ,RDW)作为血常规中的一项参数,反映红细胞大小异质性。近年来的研究证实,RDW值与心血管疾病间具有重要相关性,RDW值升高预示急性冠状动脉综合征患者不良预后,RDW是急性冠状动脉综合征患者预后的独立预测因子。现就RDW值在急性冠状动脉综合征患者预后、作用机制及其临床应用价值的研究进展做一综述。

  14. 红细胞分布宽度在肺部疾病中的临床价值%The clinical value of red cell distribution width in pulmonary diseases

    Institute of Scientific and Technical Information of China (English)

    杨妮; 柯蕊; 刘原

    2015-01-01

    红细胞分布宽度(red cell distribution width,RDW)可反映外周血红细胞大小不一的程度,是评价红细胞异质性的参数,临床上常用于贫血的诊断和鉴别诊断。近年来,RDW 在评估肺部疾病严重程度和预后中的作用逐步得到了人们的重视。研究证实,RDW 的变化可能是整体上反映与患者病情和预后密切相关的因素,从而在提示肺部疾病的病变程度和远期预后中发挥重要作用。%Red cell distribution width (RDW)is a measurement of the size variation as well as an index of the heterogeneity of the erythrocytes.It is used clinically to differentiate different types of anemia.Recently,a strong association of RDW levels with clinical parameters and prognosis of lung disease has drawn people′s attention.It had been demonstrated that RDW values may reflect many factors which associated with the patient′s condition and prognosis,thus play an important role in predicting the severity and long-term prognosis of lung diseases.

  15. The distribution of equivalent widths in long GRB afterglow spectra

    CERN Document Server

    Postigo, A de Ugarte; Thoene, C C; Christensen, L; Gorosabel, J; Milvang-Jensen, B; Schulze, S; Jakobsson, P; Wiersema, K; Sanchez-Ramirez, R; Leloudas, G; Zafar, T; Malesani, D; Hjorth, J

    2012-01-01

    The extreme brightness of gamma-ray burst (GRB) afterglows and their simple spectral shape make them ideal beacons to study the interstellar medium of their host galaxies through absorption line spectroscopy. Using 69 low-resolution GRB afterglow spectra, we conduct a study of the rest-frame equivalent width (EW) distribution of features with an average rest-frame EW larger than 0.5 A. To compare an individual GRB with the sample, we develop EW diagrams as a graphical tool, and we give a catalogue with diagrams for the 69 spectra. We introduce a line strength parameter (LSP) that allows us to quantify the strength of the absorption features as compared to the sample by a single number. Using the distributions of EWs of single-species features, we derive the distribution of column densities by a curve of growth (CoG) fit. We find correlations between the LSP and the extinction of the GRB, the UV brightness of the host galaxies and the neutral hydrogen column density. However, we see no significant evolution of...

  16. 红细胞分布宽度和白细胞水平与冠心病的关系%Relationship of red blood cell distribution width and white blood cell count with coronary heart disease

    Institute of Scientific and Technical Information of China (English)

    孙洁静; 刘德平; 李华; 李辉; 张妮

    2015-01-01

    目的 观察红细胞分布宽度和白细胞水平与冠心病及冠状动脉病变的关系. 方法 选择行冠状动脉造影术患者590例,根据冠状动脉造影术结果分为冠心病组383例和对照组207例,并按冠状动脉病变支数将冠心病组分为不同的亚组,计算冠状动脉病变Gensini评分,比较各组间红细胞分布宽度和白细胞水平的差异,以及分析其与冠状动脉病变程度的相关性. 结果 冠心病组红细胞分布宽度和白细胞水平分别为(13.06±0.57)%、(6.33±1.56)×109/L,明显高于对照组(12.63±0.49)%、(5.86±1.29)×109/L(t=9.771、3.728,均P=0.000),并随着冠状动脉病变支数的增加而升高(F=51.454、7.544,均P=0.000),且与冠状动脉Gensini评分呈正相关(r=0.414、0.111,P=0.000、0.030);红细胞分布宽度与白细胞水平呈正相关(r=0.108,P=0.009).红细胞分布宽度对冠心病的预测价值进行受试者工作特征曲线(ROC)分析结果显示,红细胞分布宽度的界值为12.75%,ROC曲线下面积为0.723(95% CI:0.680~0.765),诊断的敏感度为67.6%,特异度为65.2%. 结论 红细胞分布宽度和白细胞水平在冠心病患者中明显升高,且与冠状动脉严重程度呈正相关,是冠心病的独立预测因子.%Objective To observe the relationship of the red blood cell distribution width and white blood cell count with coronary heart disease and coronary artery lesions.Methods Totally 590 patients undergoing coronary angiography were selected and divided into two groups based on the results of coronary angiography:coronary heart disease group (n=383) and control group (n=207).Based on the number of coronary lesions,patients in coronary heart disease were divided into different subgroup.The Gensini scores of coronary lesions were assessed.The differences in red blood cell distribution and white blood cell count were compared among different groups,and the correlations of coronary lesions with red blood cell distribution

  17. Relation between Red Cell Distribution Width and Fibroblast Growth Factor 23 Cleaving in Patients with Chronic Kidney Disease and Heart Failure

    NARCIS (Netherlands)

    van Breda, Fenna; Emans, Mireille E.; van der Putten, Karien; Braam, Branko; van Ittersum, Frans J.; Kraaijenhagen, Rob J.; de Borst, Martin H.; Vervloet, Marc; Gaillard, Carlo A. J. M.

    2015-01-01

    Objective In chronic kidney disease (CKD), both anemia and deregulated phosphate metabolism are common and predictive of adverse outcome. Previous studies suggest that iron status influences phosphate metabolism by modulating proteolytic cleavage of FGF23 into C-terminal fragments. Red cell distribu

  18. Índice de anisocitose eritrocitária (RDW: diferenciação das anemias microcíticas e hipocrômicas Red blood cell distribution width (RDW: differentiation of microcytic and hypochromic anemias

    Directory of Open Access Journals (Sweden)

    Januária F. Matos

    2008-04-01

    Full Text Available A anemia ferropriva, talassemia menor e anemia de doença crônica são as anemias microcíticas e hipocrômicas mais comuns em nosso meio. O diagnóstico diferencial das referidas anemias é de grande importância clínica; contudo, muitas vezes é complexo em virtude de concomitância de doenças, além de demandar tempo e apresentar custos significativos. Com o propósito de conferir maior simplicidade e eficiência ao diagnóstico diferencial destas anemias, o uso de índices derivados de modernos contadores automáticos tem sido sugerido. Entre estes, pode ser citado o índice de anisocitose eritrocitária (RDW, que indica o grau de variabilidade do tamanho das hemácias. Neste estudo, o poder de discriminação deste índice quanto ao tipo de anemia microcítica e hipocrômica foi avaliado em um grupo de 159 pacientes sabidamente portadores de um quadro de anemia causado por deficiência de ferro, beta talassemia menor ou uma anemia de doença crônica. Não foi observada diferença significativa para o RDW entre os três grupos de anemias microcíticas, indicando não ser este índice uma ferramenta útil para a diferenciação entre anemia ferropriva, beta talassemia menor e anemia de doença crônica.Iron deficiency anemia, the thalassemia trait and chronic disease anemia are the most common microcytic and hypochromic anemias in the Brazilian population. Differential diagnosis of these anemias is of great clinical importance however, frequently, it is complex due to coexistence of diseases, as well as being time consuming and expensive. In order to simplify and increase efficiently of checking the differential diagnoses of these anemias, the use of indexes derived from modern blood cell counters has been suggested. Among them, is the index called red blood cell distribution width which indicates the variability in red blood cell size. In this study, the discriminative power of the red blood cell distribution width in differentiating

  19. Progress in clinical application of red blood cell distribution width in cardiovascular diseases%红细胞分布宽度在心血管疾病的临床应用进展

    Institute of Scientific and Technical Information of China (English)

    王钢; 华琦

    2015-01-01

    红细胞分布宽度(RDW)是测定血液循环中红细胞体积大小是否具有均一性、形态可变性和大小变异性的一个指标,常结合红细胞平均体积用于诊断贫血。研究表明RDW升高可以在心血管疾病的预测及诊断中提供有价值的线索。本篇综述介绍RDW在心血管疾病中的临床应用。%The red blood cell distribution width (RDW) is a measure of the variation of red blood cell (RBC, also known as erythrocytes), which is typically used in combination with mean corpuscular volume to diagnose anemia. Recently, a number of studies have shown that an increased RDW is a strong and independent predictor of prognosis in cardiovascular disease (CVD). Although the mechanism is still unclear, nevertheless, RDW is an easy, inexpensive, and routinely reported test which might supply diagnostic and prognostic information for patients with CVD. This article reviewed the promising progress in RDW application in cardiovascular disease.

  20. Research progress on the relationship between red cell distribution width and liver disease%红细胞分布宽度与肝脏疾病的关系

    Institute of Scientific and Technical Information of China (English)

    林青; 石建凤; 王莉

    2015-01-01

    Red cell distribution width (RDW) is an objective indicator of red blood cell (RBC) heterogeneity which reflects size variability of RBC.Rise of RDW associates many disease,especially with cardiovascular disease.The association of RDW and liver disease focuses on the relationship with severity of HBV-associated liver disease and nonalcoholic fatty liver disease and with stage of liver fibrosis.Research progresses on these aspects are reviewed in this paper.%红细胞分布宽度(RDW)是红细胞异质性的客观指标,反映了红细胞大小不均一性.RDW升高与许多疾病相关,特别是心血管疾病,而与肝脏疾病的关系研究主要集中于与慢性HBV感染相关的疾病和非酒精性脂肪性肝病纤维化程度以及疾病严重程度的相关性上.此文就RDW与上述肝脏疾病相关性研究的进展进行综述.

  1. Dependence of Wave Height Distribution on Spectral Width and Wave Steepness

    Institute of Scientific and Technical Information of China (English)

    文凡; 吴自库; 吕红民

    2004-01-01

    In this paper experimental wind wave data are analyzed. It is found that differences in spectral width will give rise to differences in wave height distribution. The effect of spectral width on the distribution is mainly in the high wave range.The effect of wave steepness is in low, medium and high wave ranges. In the high wave range the effect of spectral width is comparable to that of wave steepness. Differences in spectral width in the observations may give rise to discrepancies in the result when wave steepness is the only parameter in the distribution.

  2. 红细胞体积分布宽度与冠心病的关系研究%Correlation of red blood cell distribution width with coronary heart disease

    Institute of Scientific and Technical Information of China (English)

    盛春梅; 马礼坤

    2014-01-01

    Objective To assess the relation between red blood cell distribution width(RDW)and coronary heart disease (CHD).Methods A total of 152 patients with CHD by coronary angiography admitted to our hospital were assigned to coronary heart disease group, and another 67 healthy cases in hospital physical examination in the same period were selected as control group.The laboratory indicators,in-cluding RDW,red blood cell count(RBC),hemoglobin(HGB),average red blood cell volume(MCV),white blood cell count(WBC),hema-tocrit(Hct),platelet count(PLT),mean platelet volume(MPV),aspartate aminotransferase(AST),alanine aminotransferase(ALT),muscle, liver(Cr),blood urea nitrogen(BUN)of the two groups were compared.The severity of coronary artery lesions was evaluated by modified Gensini score method,and its correlation with RDW was analyzed.Results Compared with control group,RDW in CHD group increased sig-nificantly(P <0.05).Conclusion RDW is associated with CHD and the severity of coronary artery lesion,which could be a predictor for the severity of pathological changes in coronary artery.%目的:探讨红细胞分布宽度(RDW)与冠心病(CHD)的关系。方法选取冠状动脉造影确诊的152例 CHD 患者为 CHD 组,67例健康体检人群为对照组。对比分析两组人群的 RDW、红细胞计数(RBC)、血红蛋白(HGB)、红细胞平均体积(MCV)、血细胞比容(Hct)、白细胞计数(WBC)、血小板计数(PLT)、平均血小板体积(MPV)、天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、血肌肝(Cr)、尿素氮(BUN);采用改良 Gensini 积分法评价冠状动脉病变的严重程度。结果与对照组比较, CHD 组 RDW 明显升高(P <0.05)。结论RDW 与 CHD 及冠状动脉病变严重程度存在一定关系,可以预测其严重程度。

  3. Combined Value of Red Blood Cell Distribution Width and Global Registry of Acute Coronary Events Risk Score for Predicting Cardiovascular Events in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.

    Directory of Open Access Journals (Sweden)

    Na Zhao

    Full Text Available Global Registry of Acute Coronary Events (GRACE risk score and red blood cell distribution width (RDW content can both independently predict major adverse cardiac events (MACEs in patients with acute coronary syndrome (ACS. We investigated the combined predictive value of RDW and GRACE risk score for cardiovascular events in patients with ACS undergoing percutaneous coronary intervention (PCI for the first time. We enrolled 480 ACS patients. During a median follow-up time of 37.2 months, 70 (14.58% patients experienced MACEs. Patients were divided into tertiles according to the baseline RDW content (11.30-12.90, 13.00-13.50, 13.60-16.40. GRACE score was positively correlated with RDW content. Multivariate Cox analysis showed that both GRACE score and RDW content were independent predictors of MACEs (hazard ratio 1.039; 95% confidence interval [CI] 1.024-1.055; p < 0.001; 1.699; 1.294-2.232; p < 0.001; respectively. Furthermore, Kaplan-Meier analysis demonstrated that the risk of MACEs increased with increasing RDW content (p < 0.001. For GRACE score alone, the area under the receiver operating characteristic (ROC curve for MACEs was 0.749 (95% CI: 0.707-0.787. The area under the ROC curve for MACEs increased to 0.805 (0.766-0.839, p = 0.034 after adding RDW content. The incremental predictive value of combining RDW content and GRACE risk score was significantly improved, also shown by the net reclassification improvement (NRI = 0.352, p < 0.001 and integrated discrimination improvement (IDI = 0.023, p = 0.002. Combining the predictive value of RDW and GRACE risk score yielded a more accurate predictive value for long-term cardiovascular events in ACS patients who underwent PCI as compared to each measure alone.

  4. The correlation of coronary heart disease with red blood cell distribution width and uric acid%红细胞分布宽度、尿酸与冠心病的相关性研究

    Institute of Scientific and Technical Information of China (English)

    张海云

    2016-01-01

    目的 探讨红细胞分布宽度(RDW)、尿酸(UA)水平与冠心病(CHD)的关系.方法 选取该院心内科住院的150例CHD患者(CHD组) ,同时选取健康对照者120例(对照组) ,对所有入选患者的RDW、红细胞(RBC)、血红蛋白(Hb)、红细胞平均体积(MCV)、白细胞(WBC)、血小板(PLT)、UA、血肌酐(Cr)、尿素氮(BUN)、血脂四项进行检测 ,并对数据进行分析.结果 与对照组RDW(12 .45 ± 0 .86)% 、UA(302 .21 ± 66 .46)μmol/L比较 ,CHD组RDW(13 .34 ± 0 .73)% 、UA(378 .32 ± 67 .20)μmol/L均显著升高 ,差异有统计学意义(P<0 .05).结论 RDW、UA对CHD的诊断具有重要意义.%Objective To investigate the correlation of coronary heart disease with the RDW(red blood cell distribution width) and UA(uric acid)level .Methods Chose 150 cases of coronary heart disease patients in our hospital(CHD group) ,at the same time selected 120 healthy cases as a normal control(control group) .Measured the RDW ,red blood cell (RBC) ,hemoglobin(Hb) ,mean corpuscular volume (MCV) ,white blood cell count(WBC) ,platelets(PLT) ,UA ,serum creatinine(Cr) ,blood urea nitrogen(BUN) , lipids four of the patients whose were selected ,then analyzed the data .Results The RDW(13 .34 ± 0 .73)% were significantly in-creased in CHD group compared with RDW (12 .45 ± 0 .86)% in the control group;The UA (378 .32 ± 67 .20)μmol/L were also significantly increased in CHD group compared with UA(302 .21 ± 66 .46)μmol/L in the control group(P<0 .05) .Conclusion RDW and UA has an important significance for the diagnosis of CHD .

  5. A Novel Multisection Distributed Feedback Laser with Varied Ridge Width for Self-Pulsation Generation

    Institute of Scientific and Technical Information of China (English)

    WAN Qin; SUN Chang-Zheng; XIONG Bing; WANG Jian; LUO Yi

    2006-01-01

    @@ A novel ridge-waveguide multisection (MS) distributed feedback (DFB) laser, which consists of two identical DFB sections but different ridge widths, is proposed to generate beating-type self-pulsations (SPs).

  6. Resonance width distribution in RMT: Weak-coupling regime beyond Porter-Thomas

    Science.gov (United States)

    Fyodorov, Yan V.; Savin, Dmitry V.

    2015-05-01

    We employ the random matrix theory (RMT) framework to revisit the distribution of resonance widths in quantum chaotic systems weakly coupled to the continuum via a finite number M of open channels. In contrast to the standard first-order perturbation theory treatment we do not a priori assume the resonance widths being small compared to the mean level spacing. We show that to the leading order in weak coupling the perturbative χ^2M distribution of the resonance widths (in particular, the Porter-Thomas distribution at M = 1) should be corrected by a factor related to a certain average of the ratio of square roots of the characteristic polynomial (“spectral determinant”) of the underlying RMT Hamiltonian. A simple single-channel expression is obtained that properly approximates the width distribution also at large resonance overlap, where the Porter-Thomas result is no longer applicable.

  7. 红细胞分布宽度与慢性心力衰竭死亡率的Meta分析%A Meta-analysis on relationship between red cell distribution width and mortality of chronic heart failure

    Institute of Scientific and Technical Information of China (English)

    毛燕; 张国荣

    2013-01-01

    Objective To investigate the predictive value of red cell distribution width (RDW) to the mortality of chronic heart failure (CHF). Methods The databases of PubMed, Embase and CNKI were retrieved to collect the studies about the relationship between RDW and the mortality of CHF. The hazard ratio (HR) and 95%confidence interval (CI) of the mortality of CHF were calculated by using Stata12.0 software. Results There were totally 6 studies included involved 13 502 cases. The analysis on homogeneity showed that all eligible studies had heterogeneity (I2=79.9%, P<0.001). The combined HR was 1.18 (95%CI:1.10-1.25, P<0.001) after using random effect model. Conclusion RDW is an index for predicting the mortality of CHF.%目的探讨红细胞分布宽度(RDW)对预测慢性心力衰竭死亡率的价值。方法检索PubMed、Embase、CNKI数据库中所有论述RDW与慢性心衰死亡率队列研究的文献,使用Stata12.0软件计算合并死亡率的风险比(HR)和95%可信区间(95%CI)。结果共纳入相关文献6篇,累计样本量13502例。对入选文献进行一致性检验,文献间具有异质性(I2=79.9%,P<0.001),采用随机效应模型合并显示高水平RDW慢性心力衰竭患者死亡风险更高(HR=1.18,95%CI:1.10~1.25,P<0.001)。结论RDW是预测慢性心力衰竭死亡率的指标。

  8. Predictive value of red cell distribution width in aged patients with community acquired pneumonia%红细胞分布宽度对老年社区获得性肺炎预后的探讨

    Institute of Scientific and Technical Information of China (English)

    陈小军; 张泓

    2015-01-01

    目的:探讨红细胞分布宽度( red cell distribution width, RDW)对老年社区获得性肺炎( community acquired pneumonia, CAP)预后的预测价值。方法回顾性分析安徽医科大学第一附属医院急诊内科及急诊重症监护室205例老年CAP患者。根据入院时RDW将患者分为4组,对比各组间相关指标( CURB-65计分、器官衰竭及ICU入住率、住院天数、30 d死亡率)的差异,并就RDW对老年CAP住院患者死亡预测价值进行统计学分析。结果 CURB-65计分、器官衰竭发生率、ICU入住率、30 d死亡率4组间进行两两比较,差异有统计学意义( P<0.05);RDW预测老年CAP死亡的受试者工作曲线( ROC)的曲线下面积( AUC)=0.75。结论 RDW可作为临床对老年CAP患者病情严重程度的评估指标之一,对预测老年CAP患者死亡预后有一定意义。%Objective To investigate the predictive value of red cell distribution width ( RDW) in the aged patients with community acquired pneumonia(CAP). Methods 205 elderly patients with CAP from the Emergency Medical Ward and Emergency Intensive Care Unit of the First Affiliated Hospital of Anhui Medical University were retrospectively analyzed.According to RDW on admission, the patients with CAP were divided into four groups.CURB-65 scores, organ failure, intensive care unit occupancy, the duration of hospital stay and 30 -day mortality outcomes were detected and compared among the groups, and RDW was statistically analyzed to predict mortality in these patients. Results Among the four groups, CURB-65, incidence of organ failure, ICU occupancy rate and 30-day mortality were statistically different (P<0.05).ROC curve was drawn to evaluate the predictive role of RDW in elderly CAP death, the area under the curve ( AUC) =0.75.Conclusion RDW can be used as a clinical evaluation of the severity of disease in elderly patients with CAP of one of the indicators.It is of some

  9. 红细胞分布宽度对老年急性肺栓塞患者近期预后的影响分析%Effect of red cell distribution width on early prognosis of elderly acute pulmonary embolism patients

    Institute of Scientific and Technical Information of China (English)

    郭倩玉; 卢成志; 夏大胜; 赵向东; 陈欣

    2013-01-01

    目的 探讨红细胞分布宽度(RDW)对老年急性肺栓塞患者近期预后的影响.方法 回顾性分析我院81例老年急性肺栓塞患者临床资料,根据RDW水平分为3组,RDW低值组27例,RDW中值组27例,RDW高值组27例,比较3组患者住院死亡、休克发生率及其他血流动力学、实验室指标.结果 随RDW水平升高,RDW低值组、RDW中值组和RDW高值组住院病死率、死亡和休克总发生率、N末端B型利钠肽前体水平明显增加(P<0.05).Pearson相关分析显示,与死亡发生的相关因素是年龄、收缩压、心率、N末端B型利钠肽前体、肌钙蛋白I、RDW(P<0.05,P<0.01).logistic多因素回归分析显示,年龄、收缩压、心率是住院死亡的独立影响因素(P<0.05,P<0.01).结论 老年急性肺栓塞患者RDW升高者住院死亡和休克的发生率增加.%Objective To study the effect of red cell distribution width on early prognosis of elderly acute pulmonary embolism patients .Methods Clinical data about 81 elderly acute pulmonary embolism patients were retrospectively analyzed .The patients were divided into low red cell distribution width group ,medium red cell distribution width group ,and high red cell distribution width group(27 in each group) .The in-hospital incidence of death ,hemodynamics change and labotatory findings were compared among the 3 groups .Results The total in-hospital incidence of death , plasma N-terminal probrain natriutetic peptide (NT-proBNP) level increased with the elevated red cell distribution width in low ,medium and high red cell distribution width groups (P<0.05). Pearson correlation analysis showed that age ,systolic blood pressure ,heart rate ,NT-proBNP ,tro-ponin I and red cell distribution width were the relative factors for in-hospital death ( P<0 .05 , P<0 .01) .Multivariate logistic regression analysis showed that age , systolic blood pressure and heart rate were the independent factors for in-hospital death ( P<0. 05 , P<0 .01

  10. Association of Red Cell Distribution Width and Serum Uric Acid in Preeclampsia%红细胞体积分布宽度及血清尿酸与先兆子痫的相关性探讨

    Institute of Scientific and Technical Information of China (English)

    郭进京; 李黎

    2013-01-01

    Objective Purpose of this study was to evaluate the relation red blood cell distribution width (RDW) and serum u-ric acid in preeclampsia.Methods A case-control study was conducted on singleton preeclamptic pregnancies deliverd between 37 and 40 weeks, gestation at Weinan Municipal Maternal and Child Health Hospital from October 2010 to December 2012 and control groups constituted 97 singleton pregnant normotensive.RDW, hemoglobin and serum uric acid concentration were determind.Results ①RDW and serum uric acid concentration were higher in preeclampsia compared with the controls (t=2.55,P=0.029 ; t= 1.425, P=0.031 respectively).②preeclampsia patients were divided into 2 groups according to RDW at baseling (14.7%) a high RDW(≥14.7%) and a low RDW (<14.7%).The uterine-incision delivery rates and placental abruption rates and low weigh fetus rates in preeclampsia patients with high RDW were more significantly statistical different with that of the a low RDW preeclampsia patients (χ2=7.58, P=0.006 ;χ2= 6.64, P=0.011;χ2 =6.84, P = 0.009 respectively).The serum uric acid concentration were not significantly different with that of controls (t=4.17, P= 0.058).②Multivarate analysis identified higher RDW were strongly risk factor in preeclampsia (OR=1.81, P=0.017).Conclusion Higher RDW lever are strongly correlated with preeclampsia patients.%目的 评价红细胞体积分布宽度(RDW)及血清尿酸与先兆子痫发病的关系.方法 采用病例-对照的研究方法,选取2010年10月~2012年12月在渭南市妇幼保健院住院,妊娠37~40周109例单胎先兆子痫患者;同时选取同孕周正常血压单胎孕妇97例为对照组,分别检测其RDW,Hb及血清尿酸等指标.结果 ①先兆子痫患者RDW及血清尿酸明显高于对照组(t=2.55,P=0.029;t=1.425,P=0.031).②以RDW基线水平14.7%为标准,高RDW(≥14.7%)先兆子痫组剖宫产率、胎盘早剥率及低体重胎儿率与低RDW(<14.7%)比较差异具有显著统

  11. Computer Simulation of Fiber Length and Width Distribution for Two Poplar Woods

    Institute of Scientific and Technical Information of China (English)

    ZHANGDongmei; HOUZhuqiang; GUANNing

    2004-01-01

    Computer simulation was carried out on fiber length and width for plantation-grown Chinese white poplar (Populus tomentosa Cart. clone) and plantation-grown poplar 1-72 (P. x eurumericana (Dode) Guiner cv.). Skewness and kurtosis of measured results exhibited that distributions of the fiber length and width departured from normal distribution. Three-parameter Weibull density function was used in this investigation and the corresponding program was written with Turbo C. The results showed that profiles of simulated length and width histograms were similar to ones of measured histograms, and that there was a pretty good agreement between simulated and measured means of fiber length and width. There was a little influence on the simulated means from seed used in random number generator and number of simulated variables. That indicated that the simulation was steady when the seed and the number were altered. Different histograms can be obtained with different values of the location, the shape, and the scale parameter corresponding to different values of the minimum, the mean, and the standard deviation for fiber length and width. The simulation presented here can be used as a tool for the studies on the variations in fiber morphology.

  12. Terrace width distribution during unstable homoepitaxial growth of GaAs(110): An experimental study

    Energy Technology Data Exchange (ETDEWEB)

    Crespillo, M.L. [Instituto de Ciencia de Materiales de Madrid (ICMM-CSIC), Sor Juana Ines de la Cruz s/n, Cantoblanco, 28049 Madrid (Spain)]. E-mail: mcrespillo@icmm.csic.es; Sacedon, J.L. [Instituto de Ciencia de Materiales de Madrid (ICMM-CSIC), Sor Juana Ines de la Cruz s/n, Cantoblanco, 28049 Madrid (Spain); Tejedor, P. [Instituto de Ciencia de Materiales de Madrid (ICMM-CSIC), Sor Juana Ines de la Cruz s/n, Cantoblanco, 28049 Madrid (Spain)

    2006-07-15

    The temporal evolution of the step bunching instability formed during GaAs homoepitaxial growth on the GaAs(110) vicinal to (111)A has been studied by atomic force microscopy (AFM) and the step-step distribution has been quantified as a function of deposition time. Analysis of the AFM data has shown that neither the terrace width distribution (TWD) nor the terrace height distribution (THD) fit to a Gaussian function in the initial stages of growth, but both evolve with time as the bunching instability develops. After deposition of 500 ML of GaAs the TWD exhibits a clear Gaussian behavior while the THD is very well fitted to a Lorentzian distribution. The GaAs surface morphology initially shows a great dispersion in terrace height and width values with a clear anisotropy along the <001> tilt direction, but evidence of self-controlled growth is observed irrespective of layer thickness.

  13. 红细胞分布宽度与冠心病相关性的性别差异探讨%Gender differences in relationship between red cell distribution width and coronary artery disease

    Institute of Scientific and Technical Information of China (English)

    马凤莲; 名盛; 刘俊; 李小林; 郭远林; 朱成刚; 徐瑞霞; 刘庚; 董倩

    2013-01-01

    目的 冠心病的临床特征具有明显的性别差异,既往研究证实红细胞分布宽度(RDW)与冠心病发生与发展有一定关系.本文探讨RDW与冠心病相关性的性别差异.方法 连续收集因胸痛疑诊冠心病的患者674例,根据冠状动脉造影(CAG)结果分为冠心病组499例(男性352例,女性147例)与对照组175例(男性89例,女性86例).分析冠心病传统危险因素在不同性别的差异,探讨RDW在不同性别冠心病患者中的分布情况.结果 不同性别总体的基线资料比较中,年龄、吸烟史、家族史、血红蛋白水平有性别差异(P<0.05),男女两组的RDW无明显差异(P>0.05).不同性别的冠心病组与对照组相比,女性冠心病组与女性对照组相比,RDW显著升高[(12.9±0.7)% vs (12.6±0.6)%,P=0.001],男性冠心病组与男性对照组相比,RDW无统计学差异[(13.0±0.8)%vs (12.8±1.0)%,P=0.144].女性冠心病患者多因素logistic回归分析显示,年龄和RDW是女性冠心病患者的独立预测因素(OR=1.07,95%CI:1.03~1.10,P<0.001 ; OR=2.03,95%CI:1.28~3.23,P<0.01).女性RDW的ROC曲线下面积(AUC)=0.63,95%CI:0.56~0.70,RDW界值为12.75%,敏感性为57.1%,特异性为66.3%.结论 RDW与冠心病之相关性存在性别差异,是女性冠心病的独立预测因素之一.%Objective To explore the gender differences in red cell distribution width (RDW) and CAD. Methods A total of 674 consecutively admitted patients from May 2011 to May 2012 in Fu Wai Hospital were analyzed. All patients had received coronary angiography (CAG) and then were divided into two groups based on the results of CAG: CAD group consisting of 499 patients (male=352, female=147), and control group consisting of 175 subjects (male=89, female=86). The clinical characteristics including traditional CAD risk factors were collected, and their gender differences and the gender differences in RDW and CAD were analysed. Results There were significant

  14. Application of red blood cell distribution width in the early diagnosis of patients with chronic heart failure%红细胞分布宽度检验在慢性心力衰竭患者早期诊断中的应用研究

    Institute of Scientific and Technical Information of China (English)

    王社盈; 唐爱国; 杨俊

    2014-01-01

    Objective To investigate the clinical significance of red blood cell distribution width in the early diagnosis of patients with chronic heart failure.Methods Seventy eight cases of chronic heart failure patients from November 2011 to November 2013 in our hospital were recruited in this study,and were divided into three different heart failure groups (Ⅱ,Ⅲ,and Ⅳ) according to the degree of heart failure; 40 healthy cases were used as control group.The red blood cell distribution width was measured among four groups.The relationship of the red blood cell distribution width and chronic heart failure was analyzed.According to the red blood cell distribution width data,patients were grouped into < 13.1%,13.1% ~ 14.5%,and > 14.5% groups.The eventual fatality rates were compared among three groups with different red blood cell distribution width.Results (1) The red blood cell distribution width was (11.63 ±0.71)%,(13.11 ±1.08)%,(14.31 ±1.52)%,and (16.83 ±0.71)% in the healthy group,andⅡ,Ⅲ,and Ⅳ heart failure groups,respectively.The red blood cell distribution width was gradually increased with the degree of heart failure,with a statistically significant difference among four groups (P < 0.05).(2) The mortality was 0 (0/32),14.8% (4/29),and 41.2% (7/ 17) in different red blood cell distribution width groups (< 13.1%,13.1% ~ 14.5%,and > 14.5%),respectively.The mortality was gradually increased with the increased red blood cell distribution width,with a statistically significant difference among three groups (P < 0.05).Conclusions Red blood cell distribution width is of great importance to detect disease degree of chronic heart failure and can guide one to effectively evaluate disease processes and therapeutic effect.%目的 研究红细胞分布宽度检验在慢性心力衰竭患者早期诊断中的意义.方法 以本院2011年11月至2013年11月间收治的78例慢性心力衰竭患者为研究对象,首先按

  15. Inferences from the Distributions of Fast Radio Burst Pulse Widths, Dispersion Measures and Fluences

    CERN Document Server

    Katz, J I

    2015-01-01

    The widths, dispersion measures, dispersion indices and fluences of Fast Radio Bursts (FRB) impose coupled constraints that all models must satisfy. Observation of dispersion indices close to their low density limit of $-2$ sets a model-independent upper bound on the electron density and a lower bound on the size of any dispersive plasma cloud. The non-monotonic dependence of burst widths (after deconvolution of instrumental effects) on dispersion measure excludes the intergalactic medium as the location of scattering that broadens the FRB in time. Temporal broadening far greater than that of pulsars at similar high Galactic latitudes implies that scattering occurs close to the sources, where high densities and strong turbulence are plausible. FRB energetics are consistent with supergiant pulses from young, fast, high-field pulsars at cosmological distances. The distribution of FRB dispersion measures is inconsistent with expanding clouds (such as SNR). It excludes space-limited distributions (such as the loc...

  16. Distribution of total radiation widths for neutron resonances of Pt isotopes

    Directory of Open Access Journals (Sweden)

    Koehler P.E.

    2015-01-01

    Full Text Available High quality neutron capture and transmission data were measured on isotopically enriched 192,194,195,196Pt and natural Pt samples at ORELA. R-matrix analysis of this data revealed resonance parameters for 159, 413, 423, 258, and 11 neutron resonances for neutron energies below 5.0, 16.0, 7.5, 16.0, and 5.0 keV for 192,194,195,196,198Pt+n, respectively. Earlier analysis of data on reduced neutron widths, Γ0n, showed that the distributions of Γ0n for 192,194Pt deviate significantly from the Porter-Thomas distribution (PTD predicted by random matrix theory. In this contribution we report on preliminary results of the analysis of distribution of total radiation widths, Γγ, in 192,194,195,196Pt+n reactions. Comparison of experimental data with predictions made within the nuclear statistical model indicates that standard models of Photon Strength Functions (PSFs and Nuclear Level Density predict Γγ distributions which are too narrow. We found that satisfactory agreement between experimental and simulated distributions can be obtained only by a strong suppression of the PSFs at low γ-ray energies and/or by violation of the usual assumption that primary transitions from neutron resonances follow the PTD. The shape of PSFs needed for reproduction of our Γγ data also nicely reproduces spectra from several (n,γ experiments on the neighbor nuclide 198Au.

  17. Influence of leads widths distribution on turbulent heat transfer between the ocean and the atmosphere

    Directory of Open Access Journals (Sweden)

    S. Marcq

    2011-10-01

    Full Text Available Leads are linear-like structures of open water within the sea ice cover that develop as the result of fracturing due to divergence or shear. Through leads, air and water come into contact and directly exchange latent and sensible heat through convective processes driven by the large temperature and moisture differences between them. In the central Arctic, leads only cover 1 to 2% of the ocean during winter, but account for more than 80% of the heat fluxes. Furthermore, narrow leads (several meters are more than twice as efficient at transmitting turbulent heat than larger ones (several hundreds of meters. We show that lead widths are power law distributed, P(X~X−a with a>1, down to very small spatial scales (20 m or below. This implies that the open water fraction is by far dominated by very small leads. Using two classical formulations, which provide first order turbulence closure for the fetch-dependence of heat fluxes, we find that the mean heat fluxes (sensible and latent over open water are up to 55 % larger when considering the lead width distribution obtained from a SPOT satellite image of the ice cover, compared to the situation where the open water fraction constitutes one unique large lead and the rest of the area is covered by ice, as it is usually considered in climate models at the grid scale. This difference may be even larger if we assume that the power law scaling of lead widths extents down to smaller (~1 m scales. Such estimations may be a first step towards a subgrid scale parameterization of the spatial distribution of open water for heat fluxes calculations in ocean/sea ice coupled models.

  18. 红细胞分布宽度检验在慢性心衰患者早期诊断中的应用效果观察%Clinical Effect Observation of Red Blood Cell Distribution Width Test in Early Diagnosis of Heart Failure in Patients with Chronic

    Institute of Scientific and Technical Information of China (English)

    巫雪飞; 李巧; 赵连山

    2015-01-01

    目的:研究红细胞分布宽度检验在慢性心力衰竭患者早期诊断中的意义。方法以我院2010年11月-2013年11月间收治的100例慢性心力衰竭作为研究对象,首先按照心力衰竭程度将其划入Ⅱ级、Ⅲ级、Ⅳ级心力衰竭组,另同时选择40例在我院同期体检健康人群作为对照组,检测四组患者的红细胞分布宽度,分析该数据与慢性心力衰竭之间的关系;随后按照红细胞分布宽度数据将患者分为<13.1%组、13.1%-14.5%组和>14.5%组,对比三组患者最终病死率的差异。结果:①健康组、Ⅱ级、Ⅲ级、Ⅳ级心力衰竭组的红细胞分布宽度数据分别为(11.63±0.71)%、(13.11±1.08)%、(14.31±1.52)%和(16.83±0.71)%,随着心力衰竭的程度提升,红细胞分布宽度越来越高,四组间比较,差异具备统计学意义(P<0.05);②红细胞分布宽度<13.1%组、13.1%-14.5%组和>14.5%组的死亡率分别为0.0%(0/45)、11.4%(4/35)、35.0%(7/20),红细胞分布宽度越大,患者的死亡率越高,,各组间病死率差异具有统计学意义(P<0.05)。结果检测慢性心力衰竭患者红细胞分布宽度,对于明确其疾病程度具有重要的意义,能够指导我们有效地评价疾病进程及治疗效果。%Objective To study the significance of red blood cell distribution width test in early diagnosis in patients with chronic heart failure.Methods 100 cases of chronic heart failure in our hospital in 2010 November-2013 year in November were treated as the research obj ect,first of all,according to the degree of heart failure put into II,III,IV heart failure group,the other while 40 cases in healthy people over the same period in our hospital physical examination as control group,four groups of patients with detection of red blood cell distribution width analysis of the

  19. The Local Lyman-$\\alpha$ Forest; 1, Distribution of HI Absorbers, Doppler Widths, and Baryon Content

    CERN Document Server

    Penton, S V; Stocke, J T; Penton, Steven V.; Stocke, John T.

    1999-01-01

    In Paper I of this series (astro-ph/9911117) we described observations of 15 extragalactic targets taken with the Hubble Space Telescope GHRS/G160M grating for studies of the low-z Lya forest. We reported the detection of 110 Lya absorbers at significance level >3 sigma in the redshift range z=0.002-0.069, over a total pathlength of 116,000 km/s. In this second paper, we evaluate the physical properties of these Lya absorbers and compare them to their high-z counterparts. The distribution of Doppler parameters is similar to that at high redshift, with mean b = 35.0 +- 16.6 km/s. The true Doppler parameter may be somewhat lower, owing to component blends and non-thermal velocities. The distribution of equivalent widths exhibits a significant break at W~133mA, with an increasing number of weak absorbers (10mA-100mA). Adopting a curve of growth with b = 25 +- 5km/s and applying a sensitivity correction as a function of equivalent width and wavelength, we derive the distribution in column density, Nh^{-1.80+-0.05...

  20. Narrowing of terrace-width distributions during growth on vicinal surfaces

    Science.gov (United States)

    Hamouda, A. BH.; Pimpinelli, A.; Einstein, T. L.

    2009-10-01

    We present analytic and numerical results for the steady-state, non-equilibrium terrace-width distribution (TWD) of steps during growth on vicinal surfaces. Kinetic Monte Carlo shows that the TWD narrows progressively with increasing flux until the model breaks down. The narrowing corresponds to kinetic repulsion between moving steps, due to the intrinsic asymmetry of the adatom diffusion current on a growing surface. With a 1-dimensional (1D) model, from a Burton-Cabrera-Frank approach, we make contact with previous work, in which the attachment asymmetry can also be due to electromigration or to asymmetry in attachment rates; we deduce an expression for the narrowing via a Fokker-Planck analysis. We illustrate how Ehrlich-Schwoebel barriers (although inducing an instability in 2D) also lead to such asymmetry and narrowing.

  1. Magnetohydrodynamic DiscWinds and LineWidth Distributions.II

    CERN Document Server

    Chajet, L S

    2016-01-01

    We study AGN emission line profiles combining an improved version of the accretion disc-wind model of Murray & Chiang with the magneto-hydrodynamic model of Emmering et al. (1992). Here we extend our previous work to consider central objects with different masses and/or luminosities. We have compared the dispersions in our model C IV linewidth distributions to observational upper limit on that dispersion, considering both smooth and clumpy torus models. Following Fine et al., we transform that scatter in the profile line-widths into a constraint on the torus geometry and show how the half-opening angle of the obscuring structure depends on the mass of the central object and the accretion rate. We find that the results depend only mildly on the dimensionless angular momentum, one of the two integrals of motion that characterise the dynamics of the self-similar ideal MHD outflows

  2. Effects of $\\rho$-meson width on pion distributions in heavy-ion collisions

    CERN Document Server

    Huovinen, Pasi; Marczenko, Michał; Morita, Kenji; Redlich, Krzysztof; Sasaki, Chihiro

    2016-01-01

    The influence of the finite width of $\\rho$ meson on the pion momentum distribution is studied quantitatively in the framework of the S-matrix approach combined with a blast-wave model to describe particle emissions from an expanding fireball. We find that the proper treatment of resonances which accounts for their production dynamics encoded in data for partial wave scattering amplitudes can substantially modify spectra of daughter particles originating in their two body decays. In particular, it results in an enhancement of the low-$p_T$ pions from the decays of $\\rho$ mesons which improves the quantitative description of the pion spectra in heavy ion collisions obtained by the ALICE collaboration at the LHC energy.

  3. Red cell distribution width and other red blood cell parameters with venous thromboembolism and mortality risk of patients with cancer%癌症患者红细胞分布宽度和其他的血红细胞参数与静脉血栓栓塞和死亡风险的相关性

    Institute of Scientific and Technical Information of China (English)

    杨文惠

    2015-01-01

    Objective:To analyze the correlation of red cell distribution width(RDW) and other red blood cell(RBC) parameters with venous thromboembolism risk and mortality rate in patients with cancer.Methods:RBC parameters of 1840 patients with cancer were detected.The main research result was the occurrence of venous thromboembolism(VTE) symptoms,and the secondary outcome was followed up for 2 years of death.Results:High RDW(more than 16%) and other red blood cells parameters were not associated with VET risk.High RDW increased the mortality risk.Conclusion:RDW and other RBC parameters have no independent correlation with VET risk of patients with cancer.And high RDW was a independent predictor of poor survival in patients with cancer.%目的:分析癌症患者红细胞分布宽度(RDW)及其他血红细胞(RBC)参数与静脉血栓栓塞风险和死亡率的相关性。方法:检测1840例癌症患者的RBC参数,主要研究结果是静脉血栓栓塞(VTE)症状的发生、次要结局是随访2年死亡。结果:高RDW(>16%)及其他血红细胞参数与VET风险无明显关联。高RDW增加死亡风险。结论:RDW及其他RBC参数与癌症患者VET风险无独立相关,而高RDW是癌症患者生存较差的独立预示因素。

  4. The effect of erythropoietin on platelet distribution width during ischemia reperfusion injury in rats

    Directory of Open Access Journals (Sweden)

    Constantinos Tsompos

    2014-04-01

    Full Text Available OBJECTIVE: Aim of this experiment study was the erythropoietin (Epo testing, on rat model and particularly on ischemia reperfusion protocol. The benefit or the non effect of that molecule was studied hematologically on platelet distribution width (PDW. METHODS: 40 rats were used of mean weight 247,7 gr. PDW was measured on these time points: on 60 min after reperfusion (groups A and C, and on 120 min after reperfusion (groups B and D, A and B without but C and D with Epo administration. RESULTS: Epo administration increased significantly the PDW levels by 0.22 % [0.034374 % - 0.4056259 %] (P= 0.0214, in accordance also with paired t-test (P= 0.0196, 2 reperfusion time decreased significantly the PDW levels by 0.27 % [-0.4483669 % - 0.0916332 %] (P= 0.0040, in accordance also with paired t-test (P= 0.0012, and 3 interaction of Epo administration and reperfusion time increased non significantly the PDW levels by 0.06 % [-0.054648 % - 0.1819207 %] (P= 0.0615. CONCLUSION: Epo administration has significant increasing short-term effects on PDW levels. However, reperfusion time attenuates significantly this effect. Their interaction seems to resemble the action of Epo administration. The following question is whether these PDW levels alterations are the cause or the result of diseases process modification.

  5. Association of Adiposity Indices with Platelet Distribution Width and Mean Platelet Volume in Chinese Adults.

    Directory of Open Access Journals (Sweden)

    Jian Hou

    Full Text Available Hypoxia is a prominent characteristic of inflammatory tissue lesions. It can affect platelet function. While mean platelet volume (MPV and platelet distribution width (PDW are sample platelet indices, they may reflect subcinical platelet activation. To investigated associations between adiposity indices and platelet indices, 17327 eligible individuals (7677 males and 9650 females from the Dongfeng-Tongji Cohort Study (DFTJ-Cohort Study, n=27009 were included in this study, except for 9682 individuals with missing data on demographical, lifestyle, physical indicators and diseases relative to PDW and MPV. Associations between adiposity indices including waist circumstance (WC, waist-to-height ratio (WHtR, body mass index (BMI, and MPV or PDW in the participants were analyzed using multiple logistic regressions. There were significantly negative associations between abnormal PDW and WC or WHtR for both sexes (ptrend<0.001 for all, as well as abnormal MPV and WC or WHtR among female participants (ptrend<0.05 for all. In the highest BMI groups, only females with low MPV or PDW were at greater risk for having low MPV (OR=1.33, 95% CI=1.10, 1.62 ptrend<0.001 or PDW (OR=1.34, 95% CI=1.14, 1.58, ptrend<0.001 than those who had low MPV or PDW in the corresponding lowest BMI group. The change of PDW seems more sensitive than MPV to oxidative stress and hypoxia. Associations between reduced PDW and MPV values and WC, WHtR and BMI values in Chinese female adults may help us to further investigate early changes in human body.

  6. 血红蛋白及红细胞分布宽度预测动静脉内瘘晚期血栓形成的研究%Hemoglobin and red cell distribution width for the prediction of late thrombosis of arteriovenous fistula

    Institute of Scientific and Technical Information of China (English)

    段书众; 董巧荣; 王景福; 张宝红

    2015-01-01

    Objective To probe relatively cheap and generally available laboratory test for predicting late thrombosis of arteriovenous fistu-la( AVF). Methods Retrospective analysis of laboratory data of hemoglobin( HGB),red cell distribution width-standard deviation( RDW-SD),red cell distribution width-coefficient of variation( RDW-CV),platelet,triglyceride and cholesterol was undertaken in 30 patients with late thrombosis of arteriovenous fistula. Thirty patients with AVF for maintenance hemodialysis but without thrombosis in the same hemodialysis center were as control. The above parameters were compared between two groups. Results The values of HGB and RDW in patients with throm-bosis were higher than those in control group,and the differences were statistically significant(all P 0. 05). Conclusion HGB and RDW may be used as the indicator for the prediction of late thrombosis of AVF.%目的:寻找廉价的、易于获得的能预测透析用动静脉内瘘晚期血栓形成的化验指标。方法回顾性研究30例动静脉内瘘晚期血栓形成患者的血红蛋白、红细胞分布宽度、血小板计数、甘油三酯、胆固醇;选择同一透析中心内瘘流量良好患者30例作为对照组,收集上述数据。比较两组间指标差异。结果晚期血栓形成者血红蛋白、红细胞分布宽度均明显高于对照组( P 0.05)。结论血红蛋白、红细胞分布宽度可作为预测动静脉内瘘晚期血栓形成的实验室指标。

  7. On microphysical processes of noctilucent clouds (NLC: observations and modeling of mean and width of the particle size-distribution

    Directory of Open Access Journals (Sweden)

    G. Baumgarten

    2010-07-01

    Full Text Available Noctilucent clouds (NLC in the polar summer mesopause region have been observed in Norway (69° N, 16° E between 1998 and 2009 by 3-color lidar technique. Assuming a mono-modal Gaussian size distribution we deduce mean and width of the particle sizes throughout the clouds. We observe a quasi linear relationship between distribution width and mean of the particle size at the top of the clouds and a deviation from this behavior for particle sizes larger than 40 nm, most often in the lower part of the layer. The vertically integrated particle properties show that 65% of the data follows the linear relationship with a slope of 0.42±0.02 for mean particle sizes up to 40 nm. For the vertically resolved particle properties (Δz = 0.15 km the slope is comparable and about 0.39±0.03. For particles larger than 40 nm the distribution width becomes nearly independent of particle size and even decreases in the lower part of the layer. We compare our observations to microphysical modeling of noctilucent clouds and find that the distribution width depends on turbulence, the time that turbulence can act (cloud age, and the sampling volume/time (atmospheric variability. The model results nicely reproduce the measurements and show that the observed slope can be explained by eddy diffusion profiles as observed from rocket measurements.

  8. Dynamics of red blood cells and vesicles in microchannels of oscillating width.

    Science.gov (United States)

    Braunmüller, S; Schmid, L; Franke, T

    2011-05-11

    We have studied the dynamics of red blood cells and fluid lipid vesicles in hydrodynamic flow fields created by microchannels with periodically varying channel width. For red blood cells we find a transition from a regime with oscillating tilt angle and fixed shape to a regime with oscillating shape with increasing flow velocity. We have determined the crossover to occur at a critical ratio L(y)/v(m) ≈ 2.2 × 10⁻³ s with channel width L(y) and red blood cell velocity v(m). These oscillations are superposed by shape transitions from a discocyte to a slipper shape at low velocities and a slipper to parachute transition at high flow velocities.

  9. A minimal width of the arrival direction distribution of ultra-high energy cosmic rays detected with the Yakutsk array

    CERN Document Server

    Ivanov, A A

    2015-01-01

    This paper presents the results of searches for anisotropy in arrival directions of ultra-high energy cosmic rays detected with the Yakutsk Array during the 1974--2008 observational period together with available data from other giant extensive air shower arrays working at present. A method of analysis based on a comparison of the minimal width of distributions in equatorial coordinates is applied. As a result, a hypothesis of isotropy in arrival directions is rejected at the $99.5\\%$ significance level. The observed decrease in the minimal width of distribution can be explained by the presence of cosmic ray sources in energy intervals and sky regions according to the recent indications inferred from data of the Yakutsk Array and Telescope Array experiments.

  10. THE MINIMUM WIDTH OF THE ARRIVAL DIRECTION DISTRIBUTION OF ULTRA-HIGH-ENERGY COSMIC RAYS DETECTED WITH THE YAKUTSK ARRAY

    Energy Technology Data Exchange (ETDEWEB)

    Ivanov, A. A., E-mail: ivanov@ikfia.ysn.ru [Shafer Institute for Cosmophysical Research and Aeronomy, 31 Lenin Avenue, Yakutsk 677980 (Russian Federation)

    2015-05-10

    This paper presents the results of searches for anisotropy in the arrival directions of ultra-high-energy cosmic rays (CRs) detected with the Yakutsk Array during the 1974–2008 observational period as well as searches in available data from other giant extensive air shower arrays working at present. A method of analysis based on a comparison of the minimum width of distributions in equatorial coordinates is used. As a result, a hypothesis of isotropy in arrival directions is rejected at the 99.5% significance level. The observed decrease in the minimum width of the distribution can be explained by the presence of CR sources in energy intervals and sky regions according to recent indications inferred from data of the Yakutsk Array and Telescope Array experiments.

  11. Influence of sea ice lead-width distribution on turbulent heat transfer between the ocean and the atmosphere

    Directory of Open Access Journals (Sweden)

    S. Marcq

    2012-02-01

    Full Text Available Leads are linear-like structures of open water within the sea ice cover that develop as the result of fracturing due to divergence or shear. Through leads, air and water come into contact and directly exchange latent and sensible heat through convective processes driven by the large temperature and moisture differences between them. In the central Arctic, leads only cover 1 to 2% of the ocean during winter, but account for more than 70% of the upward heat fluxes. Furthermore, narrow leads (several meters are more than twice as efficient at transmitting turbulent heat than larger ones (several hundreds of meters. We show that lead widths are power law distributed, P(X~X−a with a>1, down to very small spatial scales (20 m or below. This implies that the open water fraction is by far dominated by very small leads. Using two classical formulations, which provide first order turbulence closure for the fetch-dependence of heat fluxes, we find that the mean heat fluxes (sensible and latent over open water are up to 55% larger when considering the lead-width distribution obtained from a SPOT satellite image of the ice cover, compared to the situation where the open water fraction constitutes one unique large lead and the rest of the area is covered by ice, as it is usually considered in climate models at the grid scale. This difference may be even larger if we assume that the power law scaling of lead widths extends down to smaller (~1 m scales. Such estimations may be a first step towards a subgrid scale parameterization of the spatial distribution of open water for heat fluxes calculations in ocean/sea ice coupled models.

  12. Atmospheric velocity spectral width measurements using the statistical distribution of pulsed CO2 lidar return signal intensities

    Science.gov (United States)

    Ancellet, Gerard M.; Menzies, Robert T.; Grant, William B.

    1989-01-01

    A pulsed CO2 lidar with coherent detection has been used to measure the correlation time of backscatter from an ensemble of atmospheric aerosol particles which are illuminated by the pulsed radiation. The correlation time of the backscatter of the return signal, which is directly related to the velocity spectral width, can be used to study the velocity structure constant of atmospheric turbulence and wind shear. Various techniques for correlation time measurement are discussed, and several measurement results are presented for the technique using the information contained in the statistical distribution of a set of lidar return signal intensities.

  13. 红细胞分布宽度对PCI治疗AMI患者心肌灌注不良的预测价值%Predictive value of red cell distribution width on poor myocardial perfusion in patients with acute myo-cardial infarction treated by PCI

    Institute of Scientific and Technical Information of China (English)

    王献忠; 朱国英; 张利峰; 李延民

    2016-01-01

    目的:研究红细胞分布宽度(RDW)对经皮冠脉介入(PCI)治疗的急性心肌梗死(AMI)患者心肌灌注不良的预测价值.方法:自2013年8月至2015年8月,选择在我院接受PCI治疗的212例ACS患者进行研究.根据血液分析仪的RDW检测结果,患者被分为RDW50%记为心肌灌注良好组(134例).比较两组患者的临床资料,并对心肌灌注影响因素进行单因素及多因素分析.结果:与RD W50% were regar- ded as good myocardial perfusion group (n=134).Clinical data were compared between two groups,and single fac- tor and multi-factor analysis were used to analyze influencing factors for myocardial perfusion.Results:Compared with RDW<13.0% group,there were significant rise in age [(62.85±5.23)years vs.(67.33±6.17)years],and significant reductions in left ventricular ejection fraction [LVEF,(52.37±6.14)% vs.(50.55±5.53)%]and STR [(0.73±0.26)vs.(0.57±0.39)]in RDW≥13.0% group,P<0.05 or <0.01. Compared with good myocardial perfusion group,there were significant reductions in percentage of RDW<13% (59.70% vs.44.87%)and LVEF [(52.25±3.81)% vs.(50.29 ± 4.08)%],and significant rise in age [(63.29 ± 1.93)years vs.(66.42 ± 2.15) years]in poor myocardial perfusion group,P<0.05 all.Multi-factor Logistic regression analysis indicated that age, LVEF and RDW were independent predictors for poor myocardial perfusion (r=3.826~6.525,P<0.01 all).Con-clusion:Red cell distribution width possesses good predictive value for poor myocardial perfusion in patients with a- cute myocardial infarction undergoing percutaneous coronary intervention,which is worth extending in clinic.

  14. Relationship of neutrophils lymphocyte ratio and red blood cell distribution width with idiopathic facial palsy%中性粒细胞淋巴细胞比及红细胞分布宽度与特发性面神经麻痹的关系

    Institute of Scientific and Technical Information of China (English)

    舒湘宁; 马跃文

    2016-01-01

    背景:红细胞分布宽度与C-反应蛋白一样,是机体炎症水平的一个标志,红细胞表面可能存在多种炎症因子受体,推测红细胞参与了炎症过程,炎症导致红细胞分布宽度增加。目的:分析中性粒细胞淋巴细胞比和红细胞分布宽度与特发性面神经麻痹的发病机制及发病时疾病的严重程度之间关系。方法:特发性面神经麻痹患者30例(实验组),使用HB(House and Brackmann Facial Grading System)评分和SB(Sunnybrook System)评分评估患者病情严重程度,将实验组按SB评分分为一般瘫痪组(30-100分)和严重瘫痪组(0-29分);按照HB评估结果分为轻度(Ⅱ/Ⅲ)、中度(Ⅳ)、重度瘫痪组(Ⅴ/Ⅵ)。同时选健康者32人做对照。对比各组间中性粒细胞淋巴细胞比、红细胞分布宽度指标的差异;分析SB评分和HB评估结果与中性粒细胞淋巴细胞比、红细胞分布宽度之间的相关性。结果与结论:实验组中性粒细胞淋巴细胞比值明显高于对照组(P<0.01);红细胞分布宽度在实验组不同疾病程度组间均存在显著差异,且与SB评分呈显著负相关(P <0.01),与HB评估等级呈显著正相关(P<0.01)。结果说明,实验组中性粒细胞淋巴细胞比值显著高于对照组,红细胞分布宽度与疾病严重程度呈正相关,提示特发性面神经麻痹发病机制与炎症相关,红细胞分布宽度指标可能对特发性面神经麻痹发病时疾病严重程度评估有参考意义。%BACKGROUND:Similarly with C-reactive protein, red blood cel distribution width can reflect the inflammatory process. Red blood cels involved in inflammatory process leads to the increase in red blood cel distribution width due to various inflammation factor receptors existingon the surface of red blood cel s. OBJECTIVE:To analyze the relationship between the neutrophils lymphocyte ratio, red blood cel distribution width and the pathogenesis andseverity

  15. Terrace-width distributions of touching steps: Modification of the fermion analogy with implications for measuring step-step interactions

    Science.gov (United States)

    Sathiyanarayanan, Rajesh; Hamouda, Ajmi Bh.; Einstein, T. L.

    2009-10-01

    Using Monte Carlo simulations, we compute the terrace-width distributions (TWDs) of surfaces in which steps can touch each other, forming multiple-atomic height steps, but cannot cross (no overhangs), and so inconsistent with the standard mapping to spinless fermions. Our results show that the generalized Wigner distribution with minor modifications at small step separations, gives a very good fit for TWDs of touching steps. The interaction strength derived from the fit parameter (ϱ) indicates an effective attraction between steps. The strength of this effective attraction decreases for larger mean-step separations and decreasing step-touching energies; describable via finite-size scaling. Hence, accurate extraction of the true repulsion strength requires multiple vicinalities.

  16. Another way to view the chain conformation broadening of the line-width distribution measured in dynamic light scattering

    Institute of Scientific and Technical Information of China (English)

    吴奇; 牛爱珍

    1999-01-01

    In dynamic laser light scattering (LLS), for a given polydisperse sample, a line-width distribution G(Γ) or the translational diffusion coefficient distribution G(D) can be obtained from the measured time correlation function. For rigid colloid particles, G(Γ) can be directly related to the hydrodynamic size distribution. However, for flexible polymer chains, G(Γ) depends not only on the chain length distribution, but also on the relaxation of the chain conformation; that is, even for a monodisperse polymer sample there still exists a chain conformation distribution. If the time scale of the chain conformation relaxation is comparable to that of the translational diffusion, such as in the case of a very long polymer chain, the conformation relaxation might lead to an additional broadening in G (Γ). This "conformation broadening" has been directly observed for the first time by comparing two G(Γ) s obtained from a poly(N-isopropyl-acrylamide) solution at~25℃ and~32℃ at which the solution is ther

  17. Distributed seeding for narrow-line width hard x-ray free-electron lasers

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Dinh Cong [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Anisimov, Petr Mikhaylovich [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Buechler, Cynthia Eileen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Lewellen, IV, John W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Marksteiner, Quinn R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-09-09

    We describe a new FEL line-narrowing technique called distributed seeding (DS), using Si(111) Bragg crystal monochromators to enhance the spectral brightness of the MaRIE hard X-ray freeelectron laser. DS differs from self-seeding in three important aspects. First, DS relies on spectral filtering of the radiation at multiple locations along the undulator, with a monochromator located every few power gain lengths. Second, DS performs filtering early in the exponential gain region before SASE spikes start to appear in the radiation longitudinal profile. Third, DS provides the option to select a wavelength longer than the peak of the SASE gain curve, which leads to improved spectral contrast of the seeded FEL over the SASE background. Timedependent Genesis simulations show the power-vs-z growth curves for DS exhibit behaviors of a seeded FEL amplifier, such as exponential growth region immediately after the filters. Of the seeding approaches considered, the two-stage DS spectra produce the highest contrast of seeded FEL over the SASE background and that the three-stage DS provides the narrowest linewidth with a relative spectral FWHM of 8 X 10-5 .

  18. Impact Of The Pulse Width Modulation On The Temperature Distribution In The Armature Of A Solenoid Valve

    Science.gov (United States)

    Goraj, R.

    2015-12-01

    In order to estimate the inductive power set in the armature of the high-speed solenoid valve (HSV) during the open loop control (OLC) using pulse width modulation (PWM) an analytical explicit formula has been derived. The simplifications taken both in the geometry and in the physical behavior of the HSV were described. The inductive power was calculated for different boundary conditions and shown as a function of the frequency of the coil current. The power set in the armature was used as an input to the thermal calculation. The thermal calculation had an objective to estimate the time dependent temperature distribution in the armature of the HSV. All the derivation steps were presented and the influence of different boundary conditions was shown and discussed. The increase of the temperature during the heating with inductive power has been evaluated both in the core and on the side surface of the HSV.

  19. Impact Of The Pulse Width Modulation On The Temperature Distribution In The Armature Of A Solenoid Valve

    Directory of Open Access Journals (Sweden)

    Goraj R.

    2015-12-01

    Full Text Available In order to estimate the inductive power set in the armature of the high-speed solenoid valve (HSV during the open loop control (OLC using pulse width modulation (PWM an analytical explicit formula has been derived. The simplifications taken both in the geometry and in the physical behavior of the HSV were described. The inductive power was calculated for different boundary conditions and shown as a function of the frequency of the coil current. The power set in the armature was used as an input to the thermal calculation. The thermal calculation had an objective to estimate the time dependent temperature distribution in the armature of the HSV. All the derivation steps were presented and the influence of different boundary conditions was shown and discussed. The increase of the temperature during the heating with inductive power has been evaluated both in the core and on the side surface of the HSV.

  20. Aspirin resistance may be identified by miR-92a in plasma combined with platelet distribution width

    DEFF Research Database (Denmark)

    Binderup, Helle Glud; Houlind, Kim; Madsen, Jonna Skov;

    2016-01-01

    OBJECTIVE: Aspirin is a widely used drug for prevention of thrombotic events in cardiovascular patients, but approximately 25% of patients experience insufficient platelet inhibition due to aspirin, and remain in risk of cardiovascular events. This study aimed to investigate the value...... of circulating miR-92a and platelet size as biomarkers of the individual response to aspirin therapy. METHODS: Blood samples were collected from 50 healthy blood donors without antithrombotic medication and 50 patients with intermittent claudication on daily aspirin therapy. Based on results from the arachidonic...... acid stimulated aggregation test on Multiplate®analyzer (ASPItest), patients were defined as aspirin resistant (n=10) or aspirin responders (n=40). Plasma levels of miR-92a were evaluated by RT-qPCR analysis and platelet distribution width (PDW) was used to assess platelet size variability. Receiver...

  1. Correlation of red blood cell distribution width and ventricular tachycardia,ventricular flutter/entricular fibrillation in hospitalized patients with chronic heart failure%慢性心力衰竭患者红细胞分布宽度与室性心动过速、心室扑动/心室颤动的相关性分析

    Institute of Scientific and Technical Information of China (English)

    朱春海; 倪晓媚; 卢益中

    2015-01-01

    目的 探讨慢性心力衰竭患者红细胞分布宽度(RDW)与室性心动过速、心室扑动/心室颤动发生的关系.方法 将96例慢性心力衰竭患者按照入院时RDW四分位分组,比较各组患者相关心功能指标、实验室检查指标,住院期间是否发生室性心动过速、心室扑动/心室颤动,用Iogistic回归方程分析RDW与慢性心力衰竭患者发生室性心动过速、心室扑动/心室颤动的关系.结果 RDW四分位分组中,从Ⅰ组到Ⅳ组,患者NT- proBNP逐渐增高(P<0.05),Ⅳ组中发生室性心动过速、心室扑动/心室颤动患者的比例(75.0%)高于Ⅲ组(41.6%)(P<0.05),Ⅲ组高于Ⅰ组(4.2%)及Ⅱ组(8.3%)(P<0.05);多因素logistic回归分析显示:RDW是室性心动过速、心室扑动/心室颤动发生的高危因素(OR=1.749,P<0.05).结论 高RDW水平与慢性心力衰竭患者室性心动过速、心室扑动/心室颤动的发生相关.%Objective To investigate the correlation of red blood cell distribution width (RDW) and ventricular tachycardia,ventricular flutter/ventricular fibrillation in hospitalized patients with chronic heart failure (CHF)).Methods 136 cases of CHF patients were divided into four groups according to quartile of RDW.Heart function,laboratory data,ventricular tachycardia and ventricular flutter/ventricular fibrillation during hospitalization were compared between groups.The relation between RDW and malignant ventricular arrhythmias was analyzed by multiple logistic regression.Results From quartile 1 to quartile 4,NT- proBNP increased gradually (P<0.05).The incidence of ventricular tachycardia and ventricular flutter/ventricular fibrillation was significantly higher in quartile 4 than quartile 3 (75.0% vs.41.6%,P<0.05),significantly higher in quartile 3 than in quartile 1 (8.3%) and quartile 2 (4.2%)(all P<0.05).Multivariable Logistic regression analysis showed that RDW was a risk factor for ventricular tachycardia and ventricular flutter

  2. Relationship between Obstructive Sleep Apnea Syndrome Accompanied by Hypertension and Red Blood Cell Distribution Width%阻塞性睡眠呼吸暂停综合征合并高血压与红细胞分布宽度的关系

    Institute of Scientific and Technical Information of China (English)

    徐劲松; 程亚慧; 夏国际

    2014-01-01

    目的:探讨阻塞性睡眠呼吸暂停综合征(OSAS)合并高血压与红细胞分布宽度(RDW)的关系。方法选择2011年1月至2013年8月在中国人民解放军第九四医院呼吸内科门诊及住院的 OSAS 合并高血压患者(OSAS合并高血压组)44例和体检中心体检的原发性高血压患者(高血压组)57例、健康体检者(正常对照组)52例。各组清晨空腹抽取肘静脉血2 mL,用全自动五分类血细胞分析仪检测红细胞(RBC)计数、血红蛋白(Hb)、RDW 及白细胞(WBC)计数,比较各组 RDW 的差异,并进行相关性分析。结果高血压组 RBC 计数、Hb、RDW 和 WBC 计数与正常对照组比较差异均无统计学意义(均 P >0.05);OSAS 合并高血压组 BMI、DBP、RBC 计数、Hb 和 RDW 均明显高于正常对照组、高血压组,SBP 明显高于正常对照组、明显低于高血压组(均 P <0.05);高血压组 SBP、DBP均明显高于正常对照组(均 P <0.05)。相关性分析结果显示,OSAS 合并高血压组 RDW 与睡眠呼吸暂停低通气指数(AHI)呈正相关(r=0.426,P <0.05),与最低氧饱和度呈负相关(r=-0.509,P <0.05)。结论高血压患者RDW 无明显改变,RDW 增高可能是 OSAS 合并高血压患者心脑血管事件的标志物。%Objective To explore the relationship between obstructive sleep apnea syndrome (OSAS)accompanied by hypertension and red blood cell distribution width(RDW).Methods Forty-four patients with OSAS accompanied by hypertension who were treated in the department of respiratory medicine in the 94th Hospital of the Chinese People’s Liberation Army from January 2011 to August 2013(OSAS accompanied by hypertension group)and 57 patients with primary hypertension(hypertension group)and 52 healthy physical examinees(normal control group)who were examined at physical examination center during the same period were selected in this

  3. Lead detection in Arctic sea ice from CryoSat-2: quality assessment, lead area fraction and width distribution

    Directory of Open Access Journals (Sweden)

    A. Wernecke

    2015-03-01

    Full Text Available Leads cover only a small fraction of the Arctic sea ice but they have a dominant effect on the turbulent exchange between the ocean and the atmosphere. A supervised classification of CryoSat-2 measurements is performed by a combination with visual MODIS scenes. For several parameters thresholds are optimized and tested in order to reproduce this prior classification. The maximum power of the waveform shows the best classification properties amongst them, including the Pulse Peakiness. With the same correct lead detection rates as of published classifiers, the amount of ice being detected as lead can be reduced by up to 40%. Lead area fraction estimates based on CryoSat-2 show a major fracturing event in the Beaufort Sea in 2013. The resulting Arctic wide lead width distribution follows a power law with an exponent of 2.47 ± 0.04 for the winter seasons from 2011 to 2014, confirming and complementing a regional study based on a high resolution SPOT image.

  4. 促红细胞生成素联合铁剂对慢性心力衰竭合并贫血患者红细胞分布宽度的影响%Influence of erythropoietin therapy with oral iron supplementation on red blood cell distribution width in chronic heart failure patients with anemia

    Institute of Scientific and Technical Information of China (English)

    林娟; 高一丹

    2015-01-01

    Objective To analyze the effect of erythropoietin therapy with oral iron supplementation on red blood cell distribution width (RDW)in chronic heart failure patients with anemia.Methods 148 patients of chronic heart failure with anemia from September 2014 to March 2015 in our hospital were included and randomly divided into two groups with the random number table,with 74 cases in each group.The control group were treated with convention-al anti heart failure therapy,the treatment group were treated with erythropoietin and oral iron supplementation on the basis of routine treatment for four weeks.RDW was tested by automatic five classification blood analyzer.The correla-tion between RDW and other detection indexes was analyzed.Results The levels of RDW in the treatment group were significantly lower than those of the control group[(13.08 ±0.792)vs (14.32 ±0.864),t =-8.974,P <0.01].Before treatment,bivariate analysis in the treatment group showed that RDW had positive correlation with NT-proBNP and high -sensitivity C -relative protein (hs -CRP)(r =0.783,P <0.01;r =0.870,P <0.01),but negative correlation with serum creatinine (Cr)and hemoglobin (r =-0.338,P <0.01;r =-0.743,P <0.01).Af-ter treatment,bivariate correlations analysis in the treatment group showed that the difference of RDW was positive correlation with the difference of NT -proBNP,high -sensitivity C -relative protein (hs -CRP)(r =0.783,P <0.01;r =0.680,P <0.01),but negative correlation with the difference of hemoglobin(r =-0.459,P <0.01),and no correlation with the others (Cr,UA,LDL,TC,TG and LVEF).Conclusion On the basis of conventional anti heart failure treatment,erythropoietin therapy with oral iron supplementation against anemia could improve heart func-tion of CHF and decrease the levels of RDW.RDW may be served as one of observing indexes of the worsening and effect judgment in chronic heart failure patients with anemia.%目的:研究促红细胞生成素联合铁剂对慢性心力衰竭合

  5. Effect of finite beam width on current separation in beam plasma system: Particle-in-Cell simulations

    CERN Document Server

    Shukla, Chandrasekhar; Patel, Kartik

    2015-01-01

    The electron beam propagation in a plasma medium is susceptible to several instabilities. In the relativistic regime typically the weibel instability leading to the current separation dominates. The linear instability analysis is carried out for a system wherein the transverse extent of the beam is infinite. Even in simulations, infinite transverse extent of the beam has been chosen. In real situations, however, beam width will always be finite. keeping this in view the role of finite beam width on the evolution of the beam plasma system has been studied here using Particle - in - Cell simulations. It is observed that the current separation between the forward and return shielding current for a beam with finite beam occurs at the scale length of the beam width itself. Consequently the magnetic field structures that form have maximum power at the scale length of the beam width. This behaviour is distinct from what happens with a beam with having an infinite extent represented by simulations in a periodic box, ...

  6. WIDTHS AND AVERAGE WIDTHS OF SOBOLEV CLASSES

    Institute of Scientific and Technical Information of China (English)

    刘永平; 许贵桥

    2003-01-01

    This paper concerns the problem of the Kolmogorov n-width, the linear n-width, the Gel'fand n-width and the Bernstein n-width of Sobolev classes of the periodicmultivariate functions in the space Lp(Td) and the average Bernstein σ-width, averageKolmogorov σ-widths, the average linear σ-widths of Sobolev classes of the multivariatequantities.

  7. The effect of lithology on valley width, terrace distribution, and coarse sediment provenance in a tectonically stable catchment with flat-lying stratigraphy

    Science.gov (United States)

    Amanda Keen-Zebert,; Hudson, Mark R.; Stephanie L. Shepherd,; Evan A. Thaler,

    2017-01-01

    How rock resistance or erodibility affects fluvial landforms and processes is an outstanding question in geomorphology that has recently garnered attention owing to the recognition that the erosion rates of bedrock channels largely set the pace of landscape evolution. In this work, we evaluate valley width, terrace distribution, and sediment provenance in terms of reach scale variation in lithology in the study reach and discuss the implications for landscape evolution in a catchment with relatively flat2

  8. A Young double-slit experiment using a single electron source: Oscillations in the angular distribution of Auger-line width

    Energy Technology Data Exchange (ETDEWEB)

    Fremont, F; Chesnel, J-Y [Universite de Caen-CEA-CNRS-EnsiCaen-CIMAP, 6 bd du Mal Juin, F-14050 Caen Cedex (France); Barrachina, R O; Suarez, S, E-mail: francois.fremont@ensicaen.f, E-mail: barra@cab.cnea.gov.a [Centro Atomico Bariloche and Instituto Balseiro 8400 S. C. de Bariloche, Rio Negro (Argentina)

    2009-11-01

    We present evidence for two-center interference effects in the autoionization of a Helium atom following a double capture process in a He''2''+ + H{sub 2} collision, by looking, not at the total intensity as in a previous article [1], but at the full width at half maximum of the energy distribution at a function of the observation angle.

  9. Comment on "Distribution of Partial Neutron Widths for Nuclei Close to a Maximum of the Neutron Strength Function"

    OpenAIRE

    Koehler, P. E.; Bečvář, F.; Krtička, M.; Harvey, J. A.; Guber, K. H.

    2011-01-01

    A recent Letter attempted to reconcile the disagreement between neutron resonance data and random matrix theory (RMT). To this end, a new formula was derived for transforming measured ({\\Gamma}_{{\\lambda}n}) to reduced ({\\Gamma}_{{\\lambda}n}^0) neutron widths for s-wave resonances ({\\lambda}=1,2,...) in nuclides near peaks of the s-wave neutron strength function. In this Comment, we show that such a rescaling would not, in general, be expected to reconcile the type of disagreement observed, a...

  10. Comment on "Distribution of Partial Neutron Widths for Nuclei Close to a Maximum of the Neutron Strength Function"

    CERN Document Server

    Koehler, P E; Krtička, M; Harvey, J A; Guber, K H

    2011-01-01

    A recent Letter attempted to reconcile the disagreement between neutron resonance data and random matrix theory (RMT). To this end, a new formula was derived for transforming measured ({\\Gamma}_{{\\lambda}n}) to reduced ({\\Gamma}_{{\\lambda}n}^0) neutron widths for s-wave resonances ({\\lambda}=1,2,...) in nuclides near peaks of the s-wave neutron strength function. In this Comment, we show that such a rescaling would not, in general, be expected to reconcile the type of disagreement observed, and demonstrate that indeed it does not for the specific cases in question. Hence, the disagreements between RMT and these data remain.

  11. Study on the relationship between mean platelet volume and platelet distribution width with coronary artery lesion in children with Kawasaki disease.

    Science.gov (United States)

    Liu, Ruixi; Gao, Fang; Huo, Junming; Yi, Qijian

    2012-01-01

    Mean platelet volume (MPV) and platelet distribution width (PDW) are correlated with platelet function and may be a more sensitive index than platelet number as a marker of clinical interest in various disorders. Therefore, this study was designed to answer the following questions: do MPV and PDW levels change in Kawasaki disease (KD), is there any relation between CAL in children with MPV and PDW and whether MPV and PDW might support a diagnosis of incomplete KD. A total of 309 KD patients and 160 sex-age matched healthy subjects were enrolled into the study. For all subjects following tests were performed: MPV, PDW, platelet count, white blood cells counts (WBC), C reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Patients with CALs were assigned to three groups depending on the extent of CALs which were visualized by echocardiography: dilatation and/or ectasia, aneurysm and giant aneurysms. We compared patients with fever and four or five of the principal criteria (complete KD, cKD) to the other patients (iKD). Compared with healthy controls a significant decrease in MPV and PDW (p platelet count, CRP and ESR (p all children with KD. There were no statistically differences in MPV and PDW between KD with CALs and KD without CALs (p > 0.05). However, MPV and PDW were significantly lower in patients with iKD than in group with cKD (p = 0.003, p = 0.014, respectively). It was first shown that patients with KD have lower MPV and PDW than control subjects. The diagnosis of iKD is challenging but can be supported by the presence of lower MPV and PDW.

  12. On the determination of the He abundance distribution in globular clusters from the width of the main sequence

    Science.gov (United States)

    Cassisi, Santi; Salaris, Maurizio; Pietrinferni, Adriano; Hyder, David

    2017-01-01

    One crucial piece of information to study the origin of multiple stellar populations in globular clusters is the range of initial helium abundances ΔY amongst the sub-populations hosted by each cluster. These estimates are commonly obtained by measuring the width in colour of the unevolved main sequence in an optical colour-magnitude diagram (CMD). The measured colour spread is then compared with predictions from theoretical stellar isochrones with varying initial He abundances to determine ΔY. The availability of UV/optical magnitudes, thanks to the Hubble Space Telescope UV Legacy Survey of Galactic GCs project, will allow the homogeneous determination of ΔY for a large Galactic globular cluster sample. From a theoretical point of view, accurate UV CMDs can efficiently disentangle the various sub-populations, and main sequence colour differences in the ACS F606W - (F606W - F814W) diagram allow an estimate of ΔY. We demonstrate that from a theoretical perspective, the (F606W - F814W) colour is an extremely reliable He-abundance indicator. The derivative dY/d(F606W - F814W), computed at a fixed luminosity along the unevolved main sequence, is largely insensitive to the physical assumptions made in stellar model computations, being more sensitive to the choice of the bolometric correction scale, and is only slightly dependent on the adopted set of stellar models. From a theoretical point of view, the (F606W - F814W) colour width of the cluster main sequence is therefore a robust diagnostic of the ΔY range.

  13. 红细胞分布宽度与阻塞性睡眠呼吸暂停低通气综合征病情和颈动脉内膜中层厚度的相关性%Relation of red blood cell distribution width with the severity and carotid intima media thickness of obstructive sleep apnea hypopnea syndrome

    Institute of Scientific and Technical Information of China (English)

    陈碧; 陈昊; 张淼; 刘文静; 赵力; 朱述阳; 张文辉

    2015-01-01

    Objective To explore the relationship between red cell distribution (RDW) level with the severity and carotid intima media thickness of obstructive sleep apnea hypopnea syndrome (OSAHS).Methods A total of 103 patients with OSAHS diagnosed by polysomnography were selected from sleep Disorders Center at Affiliated Hospital of Xuzhou Medical College between January 2013 and August 2014.Twenty-eight healthy adult individuals matched for age and body mass index (BMI) were enrolled as the control group in this study.The blood routine parameters including RDW,hemoglobin level,and mean corpuscular volume (MCV) were determined.The carotid intima-mesa thickness (IMT) was measured by color Doppler uhrasonography.In addition,the correlations were analyzed between RDW with the severity and carotid IMT of OSAHS.Results The RDW values were significantly increased in moderate to severe OSAHS patients compared to the controls (all P <0.05).The RDW was positively correlated with AHI and negatively correlated with minimum SaO2.The carotid IMT was higher in milder to severe OSAHS patients than that in controls and there was a significant difference in carotid IMT among three OSAHS groups (all P <0.05).RDW in OSAHS patients was positively correlated with carotid IMT(r =0.52,P < 0.001).Conclusions RDW was significantly increased in OSAHS patients and was positively correlated with the severity and carotid IMT of OSAHS.These findings suggest that RDW may be a predictive marker of OSAHS severity and carotid artery atherosclerosis in OSAHS.%目的 探讨OSAHS患者红细胞分布宽度(RDW)与病情严重程度和颈动脉粥样硬化的相关性.方法 选取2013~2014年间在徐州医学院附属医院经多导睡眠监测(PSG)确诊的OSAHS患者103例,以及年龄、性别、体质量指数相匹配的28名健康对照者为研究对象,测定血RDW、红细胞计数(RBC)、血红蛋白(HB)、平均红细胞体积(MCV)等血常规参数,应用彩色多普勒超声仪检测颈

  14. On the determination of the He abundance distribution in globular clusters from the width of the main sequence

    CERN Document Server

    Cassisi, Santi; Pietrinferni, Adriano; Hyde, David

    2016-01-01

    One crucial piece of information to study the origin of multiple stellar populations in globular clusters, is the range of initial helium abundances $\\Delta{Y}$ amongst the sub-populations hosted by each cluster. These estimates are commonly obtained by measuring the width in colour of the unevolved main sequence in an optical colour-magnitude-diagram. The measured colour spread is then compared with predictions from theoretical stellar isochrones with varying initial He abundances, to determine $\\Delta{Y}$. The availability of UV/optical magnitudes thanks to the {\\sl HST UV Legacy Survey of Galactic GCs} project, will allow the homogeneous determination of $\\Delta{Y}$ for a large Galactic globular cluster sample. From a theoretical point of view, accurate UV CMDs can efficiently disentangle the various sub-populations, and main sequence colour differences in the ACS $F606W-(F606W-F814W)$ diagram allow an estimate of $\\Delta{Y}$. We demonstrate that from a theoretical perspective the ($F606W-F814W$) colour is...

  15. Correlation between red blood cell distrubition width and glycated hemoglobin in diabetic and nondiabetic patients

    Directory of Open Access Journals (Sweden)

    Aslıhan Dilara Demir

    2016-09-01

    Results ― No statistically significant difference was observed between the diabetic and nondiabetic groups in age, male and female distribution and RDW. No statistically significant correlation was observed between RDW and age and HbA1C in order in the nondiabetic group. While a correlation which is statistically significant and in the same direction was determine between age and RDW among the diabetic group, a statistically significant correlation was not between HbA1C and RDW. Among all cases a correlation which is statistically meaningful and in the same direction was detected between age and RDW. But a statistically significant correlation was not found between HbA1C and RDW among all cases. Conclusion ― According to the available results, no statistically significant correlation was determined between HbA1C and RDW in the nondiabetic patients, diabetic group or in total. But in order to provide more clearance, we believe that studies with more patients would be useful.

  16. Chemical elements distribution in cells

    Science.gov (United States)

    Ortega, R.

    2005-04-01

    Analysing, imaging and understanding the cellular chemistry, from macromolecules to monoatomic elements, is probably a major challenge for the scientific community after the conclusion of the genome project. In order to probe the distribution of elements in cells, especially the so-called inorganic elements, it is necessary to apply microanalytical techniques with sub-micrometer resolution and high chemical sensitivity. This paper presents the current status of chemical element imaging inside cells, and a comparison of the different analytical techniques available: nuclear microprobe, electron microprobe and electron energy loss spectroscopy, synchrotron radiation microprobe, secondary ion mass spectrometry and fluorescence microscopy methods. Examples of intracellular chemical elements distributions relevant to cancer pharmacology, medical imaging, metal carcinogenesis and neuropathology studies obtained by nuclear microprobe and other microanalytical techniques are presented.

  17. A deterministic width function model

    Directory of Open Access Journals (Sweden)

    C. E. Puente

    2003-01-01

    Full Text Available Use of a deterministic fractal-multifractal (FM geometric method to model width functions of natural river networks, as derived distributions of simple multifractal measures via fractal interpolating functions, is reported. It is first demonstrated that the FM procedure may be used to simulate natural width functions, preserving their most relevant features like their overall shape and texture and their observed power-law scaling on their power spectra. It is then shown, via two natural river networks (Racoon and Brushy creeks in the United States, that the FM approach may also be used to closely approximate existing width functions.

  18. Acid distribution in phosphoric acid fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Okae, I.; Seya, A.; Umemoto, M. [Fuji Electric Co., Ltd., Chiba (Japan)

    1996-12-31

    Electrolyte acid distribution among each component of a cell is determined by capillary force when the cell is not in operation, but the distribution under the current load conditions had not been clear so far. Since the loss of electrolyte acid during operation is inevitable, it is necessary to store enough amount of acid in every cell. But it must be under the level of which the acid disturbs the diffusion of reactive gases. Accordingly to know the actual acid distribution during operation in a cell is very important. In this report, we carried out experiments to clarify the distribution using small single cells.

  19. CD(4) has bounded width

    CERN Document Server

    Carvalho, Catarina; Marković, Petar; Maróti, Miklós

    2007-01-01

    We prove that the constraint languages invariant under a short sequence of J\\'onsson terms (containing at most three non-trivial ternary terms) are tractable by showing that they have bounded width. This improves the previous result by Kiss and Valeriote and presents some evidence that the Larose-Zadori conjecture holds in the congruence-distributive case.

  20. Spaceflight alters immune cell function and distribution

    Science.gov (United States)

    Sonnenfeld, Gerald; Mandel, Adrian D.; Konstantinova, Irina V.; Berry, Wallace D.; Taylor, Gerald R.; Lesniak, A. T.; Fuchs, Boris B.; Rakhmilevich, Alexander L.

    1992-01-01

    Experiments are described which were performed onboard Cosmos 2044 to determine spaceflight effects on immunologically important cell function and distribution. Results indicate that bone marrow cells from flown and suspended rats exhibited a decreased response to a granulocyte/monocyte colony-stimulating factor compared with the bone marrow cells from control rats. Bone marrow cells showed an increase in the percentage of cells expressing markers for helper T-cells in the myelogenous population and increased percentages of anti-asialo granulocyte/monocyte-1-bearing interleulin-2 receptor bearing pan T- and helper T-cells in the lymphocytic population.

  1. Quantification of cell-free layer thickness and cell distribution of blood by optical coherence tomography

    Science.gov (United States)

    Lauri, Janne; Bykov, Alexander; Fabritius, Tapio

    2016-04-01

    A high-speed optical coherence tomography (OCT) with 1-μm axial resolution was applied to assess the thickness of a cell-free layer (CFL) and a spatial distribution of red blood cells (RBC) next to the microchannel wall. The experiments were performed in vitro in a plain glass microchannel with a width of 2 mm and height of 0.2 mm. RBCs were suspended in phosphate buffered saline solution at the hematocrit level of 45%. Flow rates of 0.1 to 0.5 ml/h were used to compensate gravity induced CFL. The results indicate that OCT can be efficiently used for the quantification of CFL thickness and spatial distribution of RBCs in microcirculatory blood flow.

  2. Analyzing the average intensity distribution and beam width evolution of phase-locked partially coherent radial flat-topped array laser beams in oceanic turbulence

    Science.gov (United States)

    Yousefi, M.; Kashani, F. D.; Mashal, A.

    2017-02-01

    In this research, an analytical expression for cross-spectral density matrix elements (and consequently, average intensity) of partially coherent flat-topped (PCFT) radial array laser beams in weak oceanic turbulence are derived based on the extended Huygens-Fresnel principle and the previously developed knowledge of the propagation of a partially coherent beam in atmosphere. Mean-squared beam width is calculated analytically using average intensity formula. The simulation is done by considering the effects of source parameters (such as the radius of the array setup’s circle and effective width of spectral degree of coherence) and turbulent ocean factors (such as the rate of dissipation of the turbulent kinetic energy per unit mass of fluid and relative strength of temperature-salinity fluctuations, Kolmogorov micro-scale, and the rate of dissipation of the mean squared temperature) in detail. It is found that when salinity fluctuations in the ocean dominate temperature fluctuations, the average intensity of the PCFT array beam becomes more broad and the array beam profile conversion process to a single wider Gaussian beam profile will occur at a faster rate. For the same turbulent conditions and the same initial beam width, the divergence of a flat-topped array beam is less than the Gaussian array beam. The simulation and calculation results are shown by graphs.

  3. CAB-DWTM for 5 μm trace-width deposition of solar cell metallization top-contacts

    Energy Technology Data Exchange (ETDEWEB)

    Justin Hoey; Drew Thompson; Matt Robinson; Zakaria Mahmud; Orven F. Swenson; Iskander S. Akhatov; Douglas L. Schulz

    2009-06-08

    This paper reviews methods for creating solar cell grid contacts and explores how cell efficiency can be increased using CAB-DW{trademark}. Specifically, the efficiency of p-i-n structure solar cells built in-house with 90 {micro}m sputtered lines and 5 {micro}m CAB-DW lines were compared. Preliminary results of the comparison show a marked improvement in solar cell efficiency using CAB-DW. In addition to this, a theoretical and experimental analysis of the dynamics of particle impaction on a substrate (i.e. whether particle stick or bounce) will be discussed including how this analysis may lead to further improvement of CAB-DW.

  4. Using infrared thermography to determine the presence and correct placement of grouted cells in single-width concrete masonry unit (CMU) walls

    Science.gov (United States)

    Stockton, Gregory R.; Allen, Lee R.

    1999-03-01

    Determining the placement of reinforcing grout in single-width CMU (Concrete Masonry Unit) walls has, in the past, been a painstaking and destructive undertaking. Usually, a test is performed because -- by accident -- missing cells are discovered when a wall penetration is retrofitted or change order is executed, requiring that the wall be opened. Often, a hammer or hammer drill is used to punch holes where the grouting is supposed to be. The test results are used to extrapolate the extent of the problem. This method falls short, since the sample is so small, that only outright fraud can be found, and excess grouting cannot be determined. This paper discusses the results of a joint effort between Stockton Infrared Thermographic Services, Inc. (SITS) and Allen Applied Infrared Technology, Inc. (AAIT) to produce a methodology for using non-destructive infrared thermography to ensure that the design specifications are being met.

  5. Distributed series resistance effects in solar cells

    DEFF Research Database (Denmark)

    Nielsen, Lars Drud

    1982-01-01

    A mathematical treatment is presented of the effects of one-dimensional distributed series resistance in solar cells. A general perturbation theory is developed, including consistently the induced spatial variation of diode current density and leading to a first-order equivalent lumped resistance...

  6. Hybrid pn-junction solar cells based on layers of inorganic nanocrystals and organic semiconductors: optimization of layer thickness by considering the width of the depletion region.

    Science.gov (United States)

    Saha, Sudip K; Guchhait, Asim; Pal, Amlan J

    2014-03-07

    We report the formation and characterization of hybrid pn-junction solar cells based on a layer of copper diffused silver indium disulfide (AgInS2@Cu) nanoparticles and another layer of copper phthalocyanine (CuPc) molecules. With copper diffusion in the nanocrystals, their optical absorption and hence the activity of the hybrid pn-junction solar cells was extended towards the near-IR region. To decrease the particle-to-particle separation for improved carrier transport through the inorganic layer, we replaced the long-chain ligands of copper-diffused nanocrystals in each monolayer with short-ones. Under illumination, the hybrid pn-junctions yielded a higher short-circuit current as compared to the combined contribution of the Schottky junctions based on the components. A wider depletion region at the interface between the two active layers in the pn-junction device as compared to that of the Schottky junctions has been considered to analyze the results. Capacitance-voltage characteristics under a dark condition supported such a hypothesis. We also determined the width of the depletion region in the two layers separately so that a pn-junction could be formed with a tailored thickness of the two materials. Such a "fully-depleted" device resulted in an improved photovoltaic performance, primarily due to lessening of the internal resistance of the hybrid pn-junction solar cells.

  7. Inflammatory Cell Distribution in Primary Merkel Cell Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Wheat, Rachel [School of Cancer Sciences and CR UK Centre for Cancer Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT (United Kingdom); Roberts, Claudia [School of Cancer Sciences and CR UK Centre for Cancer Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT (United Kingdom); University Hospitals Birmingham NHS Foundation Trust, New Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB (United Kingdom); Waterboer, Tim [Infection and Cancer Program, DKFZ (German Cancer Research Centre), 69120 Heidelberg (Germany); Steele, Jane [Human Biomaterials Resource Centre, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT (United Kingdom); Marsden, Jerry [University Hospitals Birmingham NHS Foundation Trust, New Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB (United Kingdom); Steven, Neil M., E-mail: n.m.steven@bham.ac.uk [School of Cancer Sciences and CR UK Centre for Cancer Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT (United Kingdom); University Hospitals Birmingham NHS Foundation Trust, New Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB (United Kingdom); Blackbourn, David J., E-mail: n.m.steven@bham.ac.uk [Department of Microbial and Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH (United Kingdom)

    2014-05-06

    Merkel cell carcinoma (MCC) is an aggressive poorly differentiated neuroendocrine cutaneous carcinoma associated with older age, immunodeficiency and Merkel cell polyomavirus (MCPyV) integrated within malignant cells. The presence of intra-tumoural CD8+ lymphocytes reportedly predicts better MCC-specific survival. In this study, the distribution of inflammatory cells and properties of CD8+ T lymphocytes within 20 primary MCC specimens were characterised using immunohistochemistry and multicolour immunofluorescent staining coupled to confocal microscopy. CD8+ cells and CD68+ macrophages were identified in 19/20 primary MCC. CD20+ B cells were present in 5/10, CD4+ cells in 10/10 and FoxP3+ cells in 7/10 specimens. Only two specimens had almost no inflammatory cells. Within specimens, inflammatory cells followed the same patchy distribution, focused at the edge of sheets and nodules and, in some cases, more intense in trabecular areas. CD8+ cells were outside vessels on the edge of tumour. Those few within malignant sheets typically lined up in fine septa not contacting MCC cells expressing MCPyV large T antigen. The homeostatic chemokine CXCL12 was expressed outside malignant nodules whereas its receptor CXCR4 was identified within tumour but not on CD8+ cells. CD8+ cells lacked CXCR3 and granzyme B expression irrespective of location within stroma versus malignant nodules or of the intensity of the intra-tumoural infiltrate. In summary, diverse inflammatory cells were organised around the margin of malignant deposits suggesting response to aberrant signaling, but were unable to penetrate the tumour microenvironment itself to enable an immune response against malignant cells or their polyomavirus.

  8. Level Width Broaden Effect

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jing-Shang

    2004-01-01

    In fitting the double-differential measurements thelevelwidth broadening effect should be taken into account properly due to Heisenberg uncertainty.Besides level width broadening effect the energy resolution in the measurements is also needed in this procedure.In general,the traditional normal Gaussian expansion is employed.However,the research indicates that to do so in this way the energy balance could not hold.For this reason,the deformed Gaussian expansion functions with exponential form for both the single energy point and continuous spectrum are introduced,with which the normalization and energy balance conditions could hold exactly in the analytical form.

  9. [Calculation of the dose distribution of high-energy electrons within and behind tissue inhomogeneities of any width. II. Influence of multiple scattering (author's transl)].

    Science.gov (United States)

    Mandour, M A; Harder, D

    1978-08-01

    The algorithn proposed in 1976 to allow for the influences of tissue inhomogeneities in electron beam dose distributions has been improved. A factor adopted from Sternheimer corrects for differences in lateral displacement by multiple scattering within the inhomogeneity resp. the equivalent layer of the homogeneous medium. The algorithm has been tested by direct comparison with Monte Carlo computations for the example of cylindrical cavities in carbon at Eo=10 MeV and resulted in a very close approximation.

  10. Magneto-optical resonance of electromagnetically induced absorption with high contrast and narrow width in a vapour cell with buffer gas

    CERN Document Server

    Brazhnikov, D V; Yudin, V I

    2014-01-01

    The method for observing the high-contrast and narrow-width resonances of electromagnetically induced absorption (EIA) in the Hanle configuration under counterpropagating light waves is proposed. We theoretically analyze the absorption of a probe light wave in presence of counterpropagating one with the same frequency as the function of a static magnetic field applied along the vectors of light waves, propagating in a vapour cell. Here, as an example, we study a "dark" type of atomic dipole transition Fg=1-->Fe=1 in D1 line of 87Rb, where usually the electromagnetically induced transparency (EIT) can be observed. To obtain the EIA signal one should proper chose the polarizations of light waves and intensities. In contrast of regular schemes for observing EIA signals (in a single travelling light wave in the Hanle configuration or in a bichromatic light field consisted of two travelling waves), the proposed scheme allows one to use buffer gas to significantly enhance properties of the resonance. Also the drama...

  11. The Red Cell Distribution Width is Strong Predictor for the in-Hospital Mortality of the CABG Patients

    Directory of Open Access Journals (Sweden)

    Hüseyin Katlandur

    2016-06-01

    Full Text Available INTRODUCTION: There are several studies about the mortality of the CABG patients with the importance of the inflammation. The aim of our study was to evaluate the relationship between RDW and in-hospital mortality in CABG patients. METHODS: A total of 346 patients undergoing coronary artery bypass grafting operation were analyzed for our study. Pre-operative 2 ml blood sample was put into tubes for evaluation all patients complete blood count. All patients underwent same anesthesia protocol. The type of CABG procedure (off-pump vs on-pump CABG was determined by the operation team. RESULTS: There was ten patients died in-hospital period (Group 1 and three hundred and thirty-six patients lived during in hospital follow up (Group 2. WBC (10.8 ± 5.2 x 103 vs 7.9 ± 2.2 x 103 p: 0.04, Neutrophil (7.3 ± 3 x 103 vs 5.1 ± 2 x 103 p: 0.03, N/L Ratio (4.8 ± 2.6 % vs 2.7 ± 1.6 % p: 0.01 and RDW (14.8 ± 1.6 % vs 13.9 ± 6.6 %, p: 0.002 values were higher in group 1 than group 2, respectively. A logistic multivariate regression analysis showed that only RDW (OR 1.860, 95% CI 1.105-3.132; p: 0.02 was an independent predictor of the development of mortality in-hospital period in CABG patients. DISCUSSION AND CONCLUSION: To our knowledge, this is the first report of an association between RDW and the development postoperative mortality in CABG patients.

  12. Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, Mean Platelet Volume and Red Cell Distribution Width Measures in Bells Palsy

    Directory of Open Access Journals (Sweden)

    Caner Sahin

    2017-01-01

    CONCLUSION: Statistically significant changes in the neutrophil count and NLR were determined in the measurements between Bells Palsy and control group (p = 0.013, p = 0.016 respectively on admission. A grade of the disease and NLR measurements had no statistically significant connection. RDW value was investigated for the first time in the literature for Bells Palsy patients.

  13. Terrace-Width Distributions (TWDs) of Touching Steps: Modification of the Fermion Analogy, with Implications for Measuring Step-Step Interactions on Vicinals

    Science.gov (United States)

    Einstein, T. L.; Sathiyanarayanan, Rajesh; Hamouda, Ajmi Bh.; Kim, Kwangmoo

    2010-03-01

    Using Monte Carlo simulations, we computefootnotetextRS, ABH, and TLE, Phys. Rev. B 80 (2009) 153415. the TWDs of surfaces in which steps can touch each other, forming multiple-atomic height steps, but cannot cross (no overhangs), and so inconsistent with the standard mapping to spinless fermions. Our numerical results show that the generalized Wigner distribution, with minor modifications at small step separations, gives a very good fit for TWDs of touching steps. (We also generate analytic results by generalizing results for extended fermions.footnotetextSiew-Ann Cheong and C.L. Henley, arXiv:0907.4228v1.) The interaction strength derived from the fit parameter indicates an effective attraction between steps, weakening the overall repulsion. The strength of this effective attraction decreases for larger mean-step separations and decreasing step-touching energies; describable via finite-size scaling. Hence, accurate extraction of the true repulsion strength requires multiple vicinalities.

  14. Flow and Pressure Distribution in Fuel Cell Manifolds

    DEFF Research Database (Denmark)

    Lebæk, Jesper; Bang, Mads; Kær, Søren Knudsen

    2010-01-01

    The manifold is an essential part of the fuel cell stack. Evidently, evenly distributed reactants are a prerequisite for an efficient fuel cell stack. In this study, the cathode manifold ability to distribute air to the cells of a 70 cell stack is investigated experimentally. By means of 20...

  15. Global synchronization of parallel processors using clock pulse width modulation

    Science.gov (United States)

    Chen, Dong; Ellavsky, Matthew R.; Franke, Ross L.; Gara, Alan; Gooding, Thomas M.; Haring, Rudolf A.; Jeanson, Mark J.; Kopcsay, Gerard V.; Liebsch, Thomas A.; Littrell, Daniel; Ohmacht, Martin; Reed, Don D.; Schenck, Brandon E.; Swetz, Richard A.

    2013-04-02

    A circuit generates a global clock signal with a pulse width modification to synchronize processors in a parallel computing system. The circuit may include a hardware module and a clock splitter. The hardware module may generate a clock signal and performs a pulse width modification on the clock signal. The pulse width modification changes a pulse width within a clock period in the clock signal. The clock splitter may distribute the pulse width modified clock signal to a plurality of processors in the parallel computing system.

  16. Analysis Of The Effect Of Flow Channel Width On The Performance Of PEMFC

    OpenAIRE

    Elif Eker; İmdat Taymaz

    2013-01-01

    In this work, it was analysed the effect of different channel width on performance of PEM fuel cell. Current density were measured on the single cells of parallel flow fields that has 25 cm² active layer, using three different kinds of channel width. The cell width and the channel height remain constant.The results show that increasing the channel width while the cell width remains constant decreases the current density.

  17. Analysis Of The Effect Of Flow Channel Width On The Performance Of PEMFC

    OpenAIRE

    Eker, Elif; Taymaz, İmdat

    2013-01-01

    In this work, it was analysed the effect of different channel width on performance of PEM fuel cell. Current density were measured on the single cells of parallel flow fields that has 25 cm² active layer, using three different kinds of channel width. The cell width and the channel height remain constant. The results show that increasing the channel width while the cell width remains constant decreases the current density.

  18. Modeling and control of fuel cell based distributed generation systems

    Science.gov (United States)

    Jung, Jin Woo

    This dissertation presents circuit models and control algorithms of fuel cell based distributed generation systems (DGS) for two DGS topologies. In the first topology, each DGS unit utilizes a battery in parallel to the fuel cell in a standalone AC power plant and a grid-interconnection. In the second topology, a Z-source converter, which employs both the L and C passive components and shoot-through zero vectors instead of the conventional DC/DC boost power converter in order to step up the DC-link voltage, is adopted for a standalone AC power supply. In Topology 1, two applications are studied: a standalone power generation (Single DGS Unit and Two DGS Units) and a grid-interconnection. First, dynamic model of the fuel cell is given based on electrochemical process. Second, two full-bridge DC to DC converters are adopted and their controllers are designed: an unidirectional full-bridge DC to DC boost converter for the fuel cell and a bidirectional full-bridge DC to DC buck/boost converter for the battery. Third, for a three-phase DC to AC inverter without or with a Delta/Y transformer, a discrete-time state space circuit model is given and two discrete-time feedback controllers are designed: voltage controller in the outer loop and current controller in the inner loop. And last, for load sharing of two DGS units and power flow control of two DGS units or the DGS connected to the grid, real and reactive power controllers are proposed. Particularly, for the grid-connected DGS application, a synchronization issue between an islanding mode and a paralleling mode to the grid is investigated, and two case studies are performed. To demonstrate the proposed circuit models and control strategies, simulation test-beds using Matlab/Simulink are constructed for each configuration of the fuel cell based DGS with a three-phase AC 120 V (L-N)/60 Hz/50 kVA and various simulation results are presented. In Topology 2, this dissertation presents system modeling, modified space

  19. Probabilistic Analysis of Crack Width

    Directory of Open Access Journals (Sweden)

    J. Marková

    2000-01-01

    Full Text Available Probabilistic analysis of crack width of a reinforced concrete element is based on the formulas accepted in Eurocode 2 and European Model Code 90. Obtained values of reliability index b seem to be satisfactory for the reinforced concrete slab that fulfils requirements for the crack width specified in Eurocode 2. However, the reliability of the slab seems to be insufficient when the European Model Code 90 is considered; reliability index is less than recommended value 1.5 for serviceability limit states indicated in Eurocode 1. Analysis of sensitivity factors of basic variables enables to find out variables significantly affecting the total crack width.

  20. Fast Rendering for Great Width Stereo Image Pair Based on Distributed Rendering%基于分布式绘制的大幅面立体像对快速浏览技术

    Institute of Scientific and Technical Information of China (English)

    刘涛; 谢剑薇; 龚雪晶; 赵兴国

    2012-01-01

    针对当前影像数据存储格式不能适应海量影像数据快速访问的情况,研究设计了大幅面立体像对的逻辑四叉树存储格式,并通过立体像对的逻辑四叉树剖分算法把普通格式的立体像对格式快速转换成逻辑四叉树存储格式。由于单机显示无法满足大幅面立体像对的高分辨率、高沉浸感的显示,因此系统研究了大幅面立体像对快速浏览的分布式结构,包括硬件选择、分布式策略和通信方式等方面。由于当前分布式网络不足以支持大规模数据的实时传输,根据帧相关性原理,研究提出了大幅面立体像对的分布式缓冲机制。最后通过实验证明该方法能够实现大幅面立体像对的实时浏览。%The current image data format cannot fit the fast access of the massive image data, so the logistic quad-tree structure has been designed for the large scale stereo image pair, and the ordinary form of stereo image pair can be fast changed into logistic quad-tree structure ones through the split method of the logistic quad-tree structure. The single machine display cannot meet the high resolution and high immersion display of the large scale stereo image pair, so the distributed structure has been studied to the fast browsing of the large scale stereo image pair, including hardware choice, distributed strategy, communications method, and so on. Because the current distributed network is insufficient to support the real-time transmission of the large-scale data, the data management mechanism has been proposed for the large scale stereo image pair according to the flame relevant principle, including distributed cache mechanism and fast access algorithm. The experiment proves that the application above technology to the fast rendering for the great width stereo image pair has realized real-time roams in the large screen stereo display.

  1. Absorbed Dose Distribution in a Pulse Radiolysis Optical Cell

    DEFF Research Database (Denmark)

    Miller, Arne; McLaughlin, W. L.

    1975-01-01

    When a liquid solution in an optical cell is irradiated by an intense pulsed electron beam, it may be important in the chemical analysis of the solution to know the distribution of energy deposited throughout the cell. For the present work, absorbed dose distributions were measured by thin...

  2. Distributed Shared Memory for the Cell Broadband Engine (DSMCBE)

    DEFF Research Database (Denmark)

    Larsen, Morten Nørgaard; Skovhede, Kenneth; Vinter, Brian

    2009-01-01

    in and out of non-coherent local storage blocks for each special processor element. In this paper we present a software library, namely the Distributed Shared Memory for the Cell Broadband Engine (DSMCBE). By using techniques known from distributed shared memory DSMCBE allows programmers to program the CELL...

  3. Bounding the Higgs boson width through interferometry.

    Science.gov (United States)

    Dixon, Lance J; Li, Ye

    2013-09-13

    We study the change in the diphoton-invariant-mass distribution for Higgs boson decays to two photons, due to interference between the Higgs resonance in gluon fusion and the continuum background amplitude for gg→γγ. Previously, the apparent Higgs mass was found to shift by around 100 MeV in the standard model in the leading-order approximation, which may potentially be experimentally observable. We compute the next-to-leading-order QCD corrections to the apparent mass shift, which reduce it by about 40%. The apparent mass shift may provide a way to measure, or at least bound, the Higgs boson width at the Large Hadron Collider through "interferometry." We investigate how the shift depends on the Higgs width, in a model that maintains constant Higgs boson signal yields. At Higgs widths above 30 MeV, the mass shift is over 200 MeV and increases with the square root of the width. The apparent mass shift could be measured by comparing with the ZZ* channel, where the shift is much smaller. It might be possible to measure the shift more accurately by exploiting its strong dependence on the Higgs transverse momentum.

  4. A closer look at the "characteristic" width of molecular cloud filaments

    CERN Document Server

    Panopoulou, G V; Skalidis, R; Tassis, K; Andrews, J J

    2016-01-01

    Filaments in Herschel molecular cloud images are found to exhibit a "characteristic width". This finding is in tension with spatial power spectra of the data, which show no indication of this characteristic scale. We demonstrate that this discrepancy is a result of the methodology adopted for measuring filament widths. First, we perform the previously used analysis technique on artificial scale-free data, and obtain a peaked width distribution of filament-like structures. Next, we repeat the analysis on three Herschel maps and reproduce the narrow distribution of widths found in previous studies $-$ when considering the average width of each filament. However, the distribution of widths measured at all points along a filament spine is broader than the distribution of mean filament widths, indicating that the narrow spread (interpreted as a "characteristic" width) results from averaging. Furthermore, the width is found to vary significantly from one end of a filament to the other. Therefore, the previously ide...

  5. Distribution of Cell in Mobile Network

    Directory of Open Access Journals (Sweden)

    Robert Bestak

    2015-01-01

    Full Text Available Femtocell concept has emerged as a cost-effective solution to manage indoor environment coverage and increasing capacity requirements. Compare to the conventional control macrocell deployment, femtocells are spread in the uncontrolled manner as they are deployed in network by customers themselves. This paper discusses multi-distance spatial analysis, Ripley's K function, to describe distribution of femtocells in a macrocell. In our study, we investigate various femtocell distributions and various numbers of femtocells in the macrocell.

  6. Universal area distributions in the monolayers of confluent mammalian cells

    Science.gov (United States)

    Wilk, Gary; Iwasa, Masatomo; Fuller, Patrick E.; Kandere-Grzybowska, Kristiana; Grzybowski, Bartosz A.

    2014-01-01

    When mammalian cells form confluent monolayers completely filling a plane, these apparently random “tilings” show regularity in the statistics of cell areas for various types of epithelial and endothelial cells. The observed distributions are reproduced by a model which accounts for cell growth and division, with the latter treated stochastically both in terms of the sizes of the dividing cells as well as the sizes of the “newborn” ones – remarkably, the modeled and experimental distributions fit well when all free parameters are estimated directly from experiments. PMID:24745461

  7. Biological width: No violation zone

    Directory of Open Access Journals (Sweden)

    Ashu Sharma

    2012-01-01

    Full Text Available Maintenance of gingival health is one of the keys for the longevity of teeth, as well as for the longevity of restorations. The concept of Biologic width has been widely described by periodontists and restorative dentists. An adequate understanding of relationship between periodontal tissues and restorative dentistry is paramount to ensure adequate form, function and esthetics, and comfort of the dentition. While most clinicians are aware of this important relationship, uncertainty remains regarding specific concepts such as biologic width and indications and applications of surgical crown lengthening. These violations lead to complications like gingival inflammation, alveolar bone loss and improper fit of the restorative component. This review gives the wide aspect of the complex question of biologic width and represents an attempt to answer some of the demands in relation to it. The article also discusses the possible methods to assess biologic width, problems that occur after improper margin placement in the periodontium and the alternative procedures for prevention of biological width violation.

  8. Study on the Match of Diffuse Square Resistance and Finger Width of Silicon Solar Cells%硅太阳电池扩散方阻与栅线宽度匹配的研究

    Institute of Scientific and Technical Information of China (English)

    王庆伟; 徐征; 赵谡玲; 张春萍; 俞健; 胡盛华; 钟思华; 刘金虎; 张鹏

    2012-01-01

    研究了扩散方块电阻及印刷栅线宽度变化对太阳电池电性能的影响,根据初步实验结果提出假设,通过进一步实验进行验证。结果表明:适当地提高扩散方阻、降低栅线宽度,有利于短路电流及效率的提升。但受限于串联电阻的增大,方阻及线宽存在一个最优值,通过Matlab软件建立模型进行模拟,求出最优解。证明了扩散方阻需要与栅线宽度很好地匹配才能达到理想的效果。%Researched is the influence of the change of diffuse square resistance and printing finger width on the electrical performance of solar cells. Firstly a hypothesis is proposed on the basis of preliminary experiment results, then it is verified by further experiments. The results show that improving diffuse square resistance and reducing the finger width appropriately can promote the short-circuit current and efficiency. But due to the increase of the serial resistance, the square resistance and finger width have an optimal value which can be resolved with the Matlab simulation model. It is proved that the diffuse square resistance and printing finger width need to match well to achieve an ideal effect.

  9. Cell-size distribution in epithelial tissue formation and homeostasis.

    Science.gov (United States)

    Puliafito, Alberto; Primo, Luca; Celani, Antonio

    2017-03-01

    How cell growth and proliferation are orchestrated in living tissues to achieve a given biological function is a central problem in biology. During development, tissue regeneration and homeostasis, cell proliferation must be coordinated by spatial cues in order for cells to attain the correct size and shape. Biological tissues also feature a notable homogeneity of cell size, which, in specific cases, represents a physiological need. Here, we study the temporal evolution of the cell-size distribution by applying the theory of kinetic fragmentation to tissue development and homeostasis. Our theory predicts self-similar probability density function (PDF) of cell size and explains how division times and redistribution ensure cell size homogeneity across the tissue. Theoretical predictions and numerical simulations of confluent non-homeostatic tissue cultures show that cell size distribution is self-similar. Our experimental data confirm predictions and reveal that, as assumed in the theory, cell division times scale like a power-law of the cell size. We find that in homeostatic conditions there is a stationary distribution with lognormal tails, consistently with our experimental data. Our theoretical predictions and numerical simulations show that the shape of the PDF depends on how the space inherited by apoptotic cells is redistributed and that apoptotic cell rates might also depend on size.

  10. Average radiation widths and the giant dipole resonance width

    Energy Technology Data Exchange (ETDEWEB)

    Arnould, M.; Thielemann, F.K.

    1982-11-01

    The average E1 radiation width can be calculated in terms of the energy Esub(G) and width GAMMAsub(G) of the Giant Dipole Resonance (GDR). While various models can predict Esub(G) quite reliably, the theoretical situation regarding ..lambda..sub(G) is much less satisfactory. We propose a simple phenomenological model which is able to provide GAMMAsub(G) values in good agreement with experimental data for spherical or deformed intermediate and heavy nuclei. In particular, this model can account for shell effects in GAMMAsub(G), and can be used in conjunction with the droplet model. The GAMMAsub(G) values derived in such a way are used to compute average E1 radiation widths which are quite close to the experimental values. The method proposed for the calculation of GAMMAsub(G) also appears to be well suited when the GDR characteristics of extended sets of nuclei are required, as is namely the case in nuclear astrophysics.

  11. Tissue distribution of adoptively transferred adherent lymphokine-activated killer cells assessed by different cell labels

    DEFF Research Database (Denmark)

    Basse, P; Herberman, R B; Hokland, M;

    1992-01-01

    Assessment of the tissue distribution of adoptively transferred adherent lymphokine-activated killer A-LAK) cells by use of 51Cr indicated that these effector cells, after an initial phase in the lungs, distributed in high numbers to liver and spleen (30% and 10% of injected dose, respectively......). However, when this experiment was repeated with 125IdUrd as cell label, fewer than 2% and 0.5% of the injected cells distributed into liver and spleen respectively. To analyse this discrepancy, we compared the tissue distribution of 51Cr- and 125IdUrd-labelled A-LAK cells with that indicated...

  12. Hybrid Exotic Meson Decay Width

    CERN Document Server

    Cook, M S

    2005-01-01

    We present results of a decay width calculation for a hybrid exotic meson(h, JPC=1-+) in the decay channel h to pi+a1. This calculation uses quenched lattice QCD and Luescher's finite box method. Operators for the h and pi+a1 states are used in a correlation matrix which was expanded by varying the smearing and fuzzing levels at source and sink points. Scattering phase shifts for a discrete set of relative pi+a1 momenta are determined using eigenvalues of the correlation matrix and formulae derived by Luescher. The phase shift data is very sparse, but fits to a Breit-Wigner model are made, resulting in a decay width of about 80 MeV.

  13. On the maximal diphoton width

    CERN Document Server

    Salvio, Alberto; Strumia, Alessandro; Urbano, Alfredo

    2016-01-01

    Motivated by the 750 GeV diphoton excess found at LHC, we compute the maximal width into $\\gamma\\gamma$ that a neutral scalar can acquire through a loop of charged fermions or scalars as function of the maximal scale at which the theory holds, taking into account vacuum (meta)stability bounds. We show how an extra gauge symmetry can qualitatively weaken such bounds, and explore collider probes and connections with Dark Matter.

  14. Probing eigenfunction nonorthogonality by parametric shifts of resonance widths

    CERN Document Server

    Savin, D V

    2013-01-01

    Recently, it has been shown that the change of resonance widths in an open system under a perturbation of its interior is a sensitive indicator of the nonorthogonality of resonance states. We apply this measure to quantify parametric motion of the resonances. In particular, a strong redistribution of the widths is linked with the maximal degree of nonorthogonality. Then for weakly open chaotic systems we discuss the role of spectral rigidity on the statistical properties of the parametric width shifts, and derive the distribution of the latter in a picket-fence model with equidistant spectrum.

  15. Gravure-Offset Printed Metallization of Multi-Crystalline Silicon Solar Cells with Low Metal-Line Width for Mass Production.

    Science.gov (United States)

    Lee, Jonghwan; Jeong, Chaehwan

    2016-05-01

    The gravure offset method has been developed toward an industrially viable printing technique for electronic circuitry. In this paper, a roller type gravure offset manufacturing process was developed to fabricate fine line for using front electrode for solar cells. In order to obtain the optimum metallization printing lines, thickness of 20 μm which is narrow line is required. The main targets are the reduction of metallized area to reduce the shading loss, and a high conductivity to transport the current as loss free as possible out of the cell. However, it is well known that there is a poor contact resistance between the front Ag electrode and the n(+) emitter. Nickel plating was conducted to prevent the increase of contact resistance and the increase of fill factor (FF). The performance of n-Si/Ag (seed layer)/Ni solar cells were observed in 609 mV of open circuit voltage, 35.54 mA/cm2 of short circuit current density, 75.75% of fill factor, and 16.04% of conversion efficiency.

  16. Resonance trapping and saturation of decay widths

    CERN Document Server

    Persson, E; Rotter, I

    1998-01-01

    Resonance trapping appears in open many-particle quantum systems at high level density when the coupling to the continuum of decay channels reaches a critical strength. Here a reorganization of the system takes place and a separation of different time scales appears. We investigate it under the influence of additional weakly coupled channels as well as by taking into account the real part of the coupling term between system and continuum. We observe a saturation of the mean width of the trapped states. Also the decay rates saturate as a function of the coupling strength. The mechanism of the saturation is studied in detail. In any case, the critical region of reorganization is enlarged. When the transmission coefficients for the different channels are different, the width distribution is broadened as compared to a chi_K^2 distribution where K is the number of channels. Resonance trapping takes place before the broad state overlaps regions beyond the extension of the spectrum of the closed system.

  17. Masses, widths, and leptonic widths of the higher upsilon resonances

    Energy Technology Data Exchange (ETDEWEB)

    Lovelock, D.M.J.; Horstkotte, J.E.; Klopfenstein, C.; Lee-Franzini, J.; Romero, L.; Schamberger, R.D.; Youssef, S.; Franzini, P.; Son, D.; Tuts, P.M.

    1985-02-04

    The masses, total widths, and leptonic widths of three triplet s-wave bb-bar states UPSILON(4S), UPSILON(5S), and UPSILON(6S) are determined from measurements of the e/sup +/e/sup -/ annihilation cross section into hadrons for 10.55

  18. CIV Line-Width Anomalies

    DEFF Research Database (Denmark)

    Denney, Kelly D.; Pogge, Richard W.; Assef, Roberto J.;

    2013-01-01

    /N data can severely limit the reliability of single-epoch mass estimates based on the CIV emission line. We combine the analysis of these new high-quality data with a reanalysis of three other samples based on high S/N spectra of the CIV emission line region. We find that a large scatter between...... the Hbeta- and CIV-based masses remains even for this high S/N sample when using the FWHM to characterize the BLR velocity dispersion and the standard virial assumption to calculate the mass. However, we demonstrate that using high-quality data and the line dispersion to characterize the CIV line width...

  19. Spreading widths of doorway states

    Energy Technology Data Exchange (ETDEWEB)

    De Pace, A., E-mail: depace@to.infn.i [Istituto Nazionale di Fisica Nucleare, Sezione di Torino, via P. Giuria 1, I-10125 Torino (Italy); Molinari, A. [Dipartimento di Fisica Teorica dell' Universita di Torino, via P. Giuria 1, I-10125 Torino (Italy); Istituto Nazionale di Fisica Nucleare, Sezione di Torino, via P. Giuria 1, I-10125 Torino (Italy); Weidenmueller, H.A. [Max-Planck-Institut fuer Kernphysik, D-69029 Heidelberg (Germany)

    2011-01-01

    As a function of energy E, the average doorway strength function S(E)-bar of a doorway state is commonly assumed to be Lorentzian in shape and characterized by two parameters, the peak energy E{sub 0} and the spreading width {Gamma}{sup {down_arrow}}. The simple picture is modified when the density of background states that couple to the doorway state changes significantly in an energy interval of size {Gamma}{sup {down_arrow}}. For that case we derive an approximate analytical expression for S(E)-bar. We test our result successfully against numerical simulations. Our result may have important implications for shell-model calculations.

  20. Spatial distributions of red blood cells significantly alter local haemodynamics.

    Directory of Open Access Journals (Sweden)

    Joseph M Sherwood

    Full Text Available Although bulk changes in red blood cell concentration between vessels have been well characterised, local distributions are generally overlooked. Red blood cells aggregate, deform and migrate within vessels, forming heterogeneous distributions which have considerable effect on local haemodynamics. The present study reports data on the local distribution of human red blood cells in a sequentially bifurcating microchannel, representing the branching geometry of the microvasculature. Imaging methodologies with simple extrapolations are used to infer three dimensional, time-averaged velocity and haematocrit distributions under a range of flow conditions. Strong correlation between the bluntness of the velocity and haematocrit profiles in the parent branch of the geometry is observed and red blood cell aggregation has a notable effect on the observed trends. The two branches of the first bifurcation show similar characteristics in terms of the shapes of the profiles and the extent of plasma skimming, despite the difference in geometric configuration. In the second bifurcation, considerable asymmetry between the branches in the plasma skimming relationship is observed, and elucidated by considering individual haematocrit profiles. The results of the study highlight the importance of considering local haematocrit distributions in the analysis of blood flow and could lead to more accurate computational models of blood flow in microvascular networks. The experimental approaches developed in this work provide a foundation for further examining the characteristics of microhaemodynamics.

  1. N-Widths and Average Widths of Besov Classes in Sobolev Spaces

    Institute of Scientific and Technical Information of China (English)

    Gui Qiao XU; Yong Sheng SUN; Yong Ping LIU

    2006-01-01

    In this paper, we consider the n-widths and average widths of Besov classes in the usual Sobolev spaces. The weak asymptotic results concerning the Kolmogorov n-widths, the linear n-widths,the Gel'fand n-widths, in the Sobolev spaces on Td, and the infinite-dimensional widths and the average widths in the Sobolev spaces on Rd are obtained, respectively.

  2. Myoepithelial cells in lobular carcinoma in situ: distribution and immunophenotype.

    Science.gov (United States)

    Wang, Ying; Jindal, Sonali; Martel, Maritza; Wu, Yaping; Schedin, Pepper; Troxell, Megan

    2016-09-01

    Myoepithelial cells have important physical and paracrine roles in breast tissue development, maintenance, and tumor suppression. Recent molecular and immunohistochemical studies have demonstrated phenotypic alterations in ductal carcinoma in situ-associated myoepithelial cells. Although the relationship of lobular carcinoma in situ (LCIS) and myoepithelial cells was described in 1980, further characterization of LCIS-associated myoepithelial cells is lacking. We stained 27 breast specimens harboring abundant LCIS with antibodies to smooth muscle myosin heavy chain, smooth muscle actin, and calponin. Dual stains for E-cadherin/smooth muscle myosin heavy chain and CK7/p63 were also performed. In each case, the intensity and distribution of staining in LCIS-associated myoepithelial cells were compared with normal breast tissue on the same slide. In 78% of the cases, LCIS-associated myoepithelial cells demonstrated decreased staining intensity for one or more myoepithelial markers. The normal localization of myoepithelial cells (flat against the basement membrane, pattern N) was seen in 96% of LCIS, yet 85% of cases had areas with myoepithelial cell cytoplasm oriented perpendicular to the basement membrane (pattern P), and in 30% of cases, myoepithelial cells appeared focally admixed with LCIS cells (pattern C). This study characterizes detailed architectural and immunophenotypic alterations of LCIS-associated myoepithelial cells. The finding of variably diminished staining favors application of several myoepithelial immunostains in clinical practice. The interaction of LCIS with myoepithelial cells, especially in light of the perpendicular and central architectural arrangements, deserves further mechanistic investigation.

  3. The PCP pathway regulates Baz planar distribution in epithelial cells

    OpenAIRE

    2016-01-01

    The localisation of apico-basal polarity proteins along the Z-axis of epithelial cells is well understood while their distribution in the plane of the epithelium is poorly characterised. Here we provide a systematic description of the planar localisation of apico-basal polarity proteins in the Drosophila ommatidial epithelium. We show that the adherens junction proteins Shotgun and Armadillo, as well as the baso-lateral complexes, are bilateral, i.e. present on both sides of cell interfaces. ...

  4. Somatic cell count distributions during lactation predict clinical mastitis

    NARCIS (Netherlands)

    Green, M.J.; Green, L.E.; Schukken, Y.H.; Bradley, A.J.; Peeler, E.J.; Barkema, H.W.; Haas, de Y.; Collis, V.J.; Medley, G.F.

    2004-01-01

    This research investigated somatic cell count (SCC) records during lactation, with the purpose of identifying distribution characteristics (mean and measures of variation) that were most closely associated with clinical mastitis. Three separate data sets were used, one containing quarter SCC (n = 14

  5. Distributed Initial Synchronization for 5G small cells

    DEFF Research Database (Denmark)

    Berardinelli, Gilberto; Tavares, Fernando Menezes Leitão; Tirkkonen, Olav;

    2014-01-01

    Time synchronization in a large network of small cells enables efficient interference management as well as advanced transmission techniques which can boost the network throughput. In this paper, we focus on the distributed initial synchronization problem and propose different solutions aiming at...

  6. Investigating Starburst Galaxy Emission Line Equivalent Widths

    Science.gov (United States)

    Meskhidze, Helen; Richardson, Chris T.

    2016-01-01

    Modeling star forming galaxies with spectral synthesis codes allows us to study the gas conditions and excitation mechanisms that are necessary to reproduce high ionization emission lines in both local and high-z galaxies. Our study uses the locally optimally-emitting clouds model to develop an atlas of starburst galaxy emission line equivalent widths. Specifically, we address the following question: What physical conditions are necessary to produce strong high ionization emission lines assuming photoionization via starlight? Here we present the results of our photoionization simulations: an atlas spanning 15 orders of magnitude in ionizing flux and 10 orders of magnitude in hydrogen density that tracks over 150 emission lines ranging from the UV to the near IR. Each simulation grid contains ~1.5x104 photoionization models calculated by supplying a spectral energy distribution, grain content, and chemical abundances. Specifically, we will be discussing the effects on the emission line equivalent widths of varying the metallicity of the cloud, Z = 0.2 Z⊙ to Z = 5.0 Z⊙, and varying the star-formation history, using the instantaneous and continuous evolution tracks and the newly released Starburst99 Geneva rotation tracks.

  7. Nuclear distribution of claudin-2 increases cell proliferation in human lung adenocarcinoma cells.

    Science.gov (United States)

    Ikari, Akira; Watanabe, Ryo; Sato, Tomonari; Taga, Saeko; Shimobaba, Shun; Yamaguchi, Masahiko; Yamazaki, Yasuhiro; Endo, Satoshi; Matsunaga, Toshiyuki; Sugatani, Junko

    2014-09-01

    Claudin-2 is expressed in human lung adenocarcinoma tissue and cell lines, although it is absent in normal lung tissue. However, the role of claudin-2 in cell proliferation and the regulatory mechanism of intracellular distribution remain undefined. Proliferation of human adenocarcinoma A549 cells was decreased by claudin-2 knockdown together with a decrease in the percentage of S phase cells. This knockdown decreased the expression levels of ZONAB and cell cycle regulators. Claudin-2 was distributed in the nucleus in human adenocarcinoma tissues and proliferating A549 cells. The nuclear distribution of ZONAB and percentage of S phase cells were higher in cells exogenously expressing claudin-2 with a nuclear localization signal than in cells expressing claudin-2 with a nuclear export signal. Nuclear claudin-2 formed a complex with ZO-1, ZONAB, and cyclin D1. Nuclear distribution of S208A mutant, a dephosphorylated form of claudin-2, was higher than that of wild type. We suggest that nuclear distribution of claudin-2 is up-regulated by dephosphorylation and claudin-2 serves to retain ZONAB and cyclin D1 in the nucleus, resulting in the enhancement of cell proliferation in lung adenocarcinoma cells.

  8. Current distribution within parallel-connected battery cells

    Science.gov (United States)

    Brand, Martin J.; Hofmann, Markus H.; Steinhardt, Marco; Schuster, Simon F.; Jossen, Andreas

    2016-12-01

    Parallel connections can be found in many battery applications. Therefore, it is of high interest to understand how the current distributes within parallel battery cells. However, the number of publications on this topic is comparably low. Furthermore, the measurement set-ups are often not clearly defined in existing publications and it is likely that additional impedances distorted the measured current distributions. In this work, the principles of current distributions within parallel-connected battery cells are investigated theoretically, with an equivalent electric circuit model, and by measurements. A measurement set-up is developed that does not significantly influence the measurements, as proven by impedance spectroscopy. On this basis, two parameter scenarios are analyzed: the ΔR scenario stands for battery cells with differing impedances but similar capacities and the ΔC scenario for differing capacities and similar impedances. Out of 172 brand-new lithium-ion battery cells, pairs are built to practically represent the ΔR and ΔC scenarios. If a charging pulse is applied to the ΔR scenario, currents initially divide according to the current divider but equalize in constant current phases. The current divider has no effect on ΔC pairs but, as a rule of thumb for long-term loads, currents divide according to the battery cell capacities.

  9. Direct measurement of the W boson width

    Energy Technology Data Exchange (ETDEWEB)

    Abazov, V.M.; /Dubna, JINR; Abbott, B.; /Oklahoma U.; Abolins, M.; /Michigan State U.; Acharya, B.S.; /Tata Inst.; Adams, M.; /Illinois U., Chicago; Adams, T.; /Florida State U.; Aguilo, E.; /Alberta U. /Simon Fraser U. /McGill U.; Ahsan, M.; /Kansas State U.; Alexeev, G.D.; /Dubna, JINR; Alkhazov, G.; /St. Petersburg, INP; Alton, A.; /Michigan U. /Northeastern U.

    2009-09-01

    We present a direct measurement of the width of the W boson using the shape of the transverse mass distribution of W {yields} e{nu} candidates selected in 1 fb{sup -1} of data collected with the D0 detector at the Fermilab Tevatron collider in p{bar p} collisions at {radical}s = 1.96 TeV. We use the same methods and data sample that were used for our recently published W boson mass measurement, except for the modeling of the recoil, which is done with a new method based on a recoil library. Our result, 2.028 {+-} 0.072 GeV, is in agreement with the predictions of the standard model and is the most precise direct measurement result from a single experiment to date.

  10. Direct measurement of the W boson width.

    Science.gov (United States)

    Abazov, V M; Abbott, B; Abolins, M; Acharya, B S; Adams, M; Adams, T; Aguilo, E; Ahsan, M; Alexeev, G D; Alkhazov, G; Alton, A; Alverson, G; Alves, G A; Ancu, L S; Andeen, T; Anzelc, M S; Aoki, M; Arnoud, Y; Arov, M; Arthaud, M; Askew, A; Asman, B; Atramentov, O; Avila, C; BackusMayes, J; Badaud, F; Bagby, L; Baldin, B; Bandurin, D V; Banerjee, S; Barberis, E; Barfuss, A-F; Bargassa, P; Baringer, P; Barreto, J; Bartlett, J F; Bassler, U; Bauer, D; Beale, S; Bean, A; Begalli, M; Begel, M; Belanger-Champagne, C; Bellantoni, L; Benitez, J A; Beri, S B; Bernardi, G; Bernhard, R; Bertram, I; Besançon, M; Beuselinck, R; Bezzubov, V A; Bhat, P C; Bhatnagar, V; Blazey, G; Blessing, S; Bloom, K; Boehnlein, A; Boline, D; Bolton, T A; Boos, E E; Borissov, G; Bose, T; Brandt, A; Brock, R; Brooijmans, G; Bross, A; Brown, D; Bu, X B; Buchholz, D; Buehler, M; Buescher, V; Bunichev, V; Burdin, S; Burnett, T H; Buszello, C P; Calfayan, P; Calpas, B; Calvet, S; Cammin, J; Carrasco-Lizarraga, M A; Carrera, E; Carvalho, W; Casey, B C K; Castilla-Valdez, H; Chakrabarti, S; Chakraborty, D; Chan, K M; Chandra, A; Cheu, E; Cho, D K; Cho, S W; Choi, S; Choudhary, B; Christoudias, T; Cihangir, S; Claes, D; Clutter, J; Cooke, M; Cooper, W E; Corcoran, M; Couderc, F; Cousinou, M-C; Cutts, D; Cwiok, M; Das, A; Davies, G; De, K; de Jong, S J; De La Cruz-Burelo, E; DeVaughan, K; Déliot, F; Demarteau, M; Demina, R; Denisov, D; Denisov, S P; Desai, S; Diehl, H T; Diesburg, M; Dominguez, A; Dorland, T; Dubey, A; Dudko, L V; Duflot, L; Duggan, D; Duperrin, A; Dutt, S; Dyshkant, A; Eads, M; Edmunds, D; Ellison, J; Elvira, V D; Enari, Y; Eno, S; Escalier, M; Evans, H; Evdokimov, A; Evdokimov, V N; Facini, G; Ferapontov, A V; Ferbel, T; Fiedler, F; Filthaut, F; Fisher, W; Fisk, H E; Fortner, M; Fox, H; Fuess, S; Gadfort, T; Galea, C F; Garcia-Bellido, A; Gavrilov, V; Gay, P; Geist, W; Geng, W; Gerber, C E; Gershtein, Y; Gillberg, D; Ginther, G; Golovanov, G; Gómez, B; Goussiou, A; Grannis, P D; Greder, S; Greenlee, H; Greenwood, Z D; Gregores, E M; Grenier, G; Gris, Ph; Grivaz, J-F; Grohsjean, A; Grünendahl, S; Grünewald, M W; Guo, F; Guo, J; Gutierrez, G; Gutierrez, P; Haas, A; Haefner, P; Hagopian, S; Haley, J; Hall, I; Hall, R E; Han, L; Harder, K; Harel, A; Hauptman, J M; Hays, J; Hebbeker, T; Hedin, D; Hegeman, J G; Heinson, A P; Heintz, U; Hensel, C; Heredia-De La Cruz, I; Herner, K; Hesketh, G; Hildreth, M D; Hirosky, R; Hoang, T; Hobbs, J D; Hoeneisen, B; Hohlfeld, M; Hossain, S; Houben, P; Hu, Y; Hubacek, Z; Huske, N; Hynek, V; Iashvili, I; Illingworth, R; Ito, A S; Jabeen, S; Jaffré, M; Jain, S; Jakobs, K; Jamin, D; Jesik, R; Johns, K; Johnson, C; Johnson, M; Johnston, D; Jonckheere, A; Jonsson, P; Juste, A; Kajfasz, E; Karmanov, D; Kasper, P A; Katsanos, I; Kaushik, V; Kehoe, R; Kermiche, S; Khalatyan, N; Khanov, A; Kharchilava, A; Kharzheev, Y N; Khatidze, D; Kirby, M H; Kirsch, M; Klima, B; Kohli, J M; Konrath, J-P; Kozelov, A V; Kraus, J; Kuhl, T; Kumar, A; Kupco, A; Kurca, T; Kuzmin, V A; Kvita, J; Lacroix, F; Lam, D; Lammers, S; Landsberg, G; Lebrun, P; Lee, H S; Lee, W M; Leflat, A; Lellouch, J; Li, L; Li, Q Z; Lietti, S M; Lim, J K; Lincoln, D; Linnemann, J; Lipaev, V V; Lipton, R; Liu, Y; Liu, Z; Lobodenko, A; Lokajicek, M; Love, P; Lubatti, H J; Luna-Garcia, R; Lyon, A L; Maciel, A K A; Mackin, D; Mättig, P; Magaña-Villalba, R; Mal, P K; Malik, S; Malyshev, V L; Maravin, Y; Martin, B; McCarthy, R; McGivern, C L; Meijer, M M; Melnitchouk, A; Mendoza, L; Menezes, D; Mercadante, P G; Merkin, M; Meyer, A; Meyer, J; Mondal, N K; Montgomery, H E; Moore, R W; Moulik, T; Muanza, G S; Mulhearn, M; Mundal, O; Mundim, L; Nagy, E; Naimuddin, M; Narain, M; Neal, H A; Negret, J P; Neustroev, P; Nilsen, H; Nogima, H; Novaes, S F; Nunnemann, T; Obrant, G; Ochando, C; Onoprienko, D; Orduna, J; Oshima, N; Osman, N; Osta, J; Otec, R; Otero y Garzón, G J; Owen, M; Padilla, M; Padley, P; Pangilinan, M; Parashar, N; Park, S-J; Park, S K; Parsons, J; Partridge, R; Parua, N; Patwa, A; Penning, B; Perfilov, M; Peters, K; Peters, Y; Pétroff, P; Piegaia, R; Piper, J; Pleier, M-A; Podesta-Lerma, P L M; Podstavkov, V M; Pogorelov, Y; Pol, M-E; Polozov, P; Popov, A V; Prewitt, M; Protopopescu, S; Qian, J; Quadt, A; Quinn, B; Rakitine, A; Rangel, M S; Ranjan, K; Ratoff, P N; Renkel, P; Rich, P; Rijssenbeek, M; Ripp-Baudot, I; Rizatdinova, F; Robinson, S; Rominsky, M; Royon, C; Rubinov, P; Ruchti, R; Safronov, G; Sajot, G; Sánchez-Hernández, A; Sanders, M P; Sanghi, B; Savage, G; Sawyer, L; Scanlon, T; Schaile, D; Schamberger, R D; Scheglov, Y; Schellman, H; Schliephake, T; Schlobohm, S; Schwanenberger, C; Schwienhorst, R; Sekaric, J; Severini, H; Shabalina, E; Shamim, M; Shary, V; Shchukin, A A; Shivpuri, R K; Siccardi, V; Simak, V; Sirotenko, V; Skubic, P; Slattery, P; Smirnov, D; Snow, G R; Snow, J; Snyder, S; Söldner-Rembold, S; Sonnenschein, L; Sopczak, A; Sosebee, M; Soustruznik, K; Spurlock, B; Stark, J; Stolin, V; Stoyanova, D A; Strandberg, J; Strang, M A; Strauss, E; Strauss, M; Ströhmer, R; Strom, D; Stutte, L; Sumowidagdo, S; Svoisky, P; Takahashi, M; Tanasijczuk, A; Taylor, W; Tiller, B; Titov, M; Tokmenin, V V; Torchiani, I; Tsybychev, D; Tuchming, B; Tully, C; Tuts, P M; Unalan, R; Uvarov, L; Uvarov, S; Uzunyan, S; van den Berg, P J; Van Kooten, R; van Leeuwen, W M; Varelas, N; Varnes, E W; Vasilyev, I A; Verdier, P; Vertogradov, L S; Verzocchi, M; Vesterinen, M; Vilanova, D; Vint, P; Vokac, P; Wagner, R; Wahl, H D; Wang, M H L S; Warchol, J; Watts, G; Wayne, M; Weber, G; Weber, M; Wenger, A; Wetstein, M; White, A; Wicke, D; Williams, M R J; Wilson, G W; Wimpenny, S J; Wobisch, M; Wood, D R; Wyatt, T R; Xie, Y; Xu, C; Yacoob, S; Yamada, R; Yang, W-C; Yasuda, T; Yatsunenko, Y A; Ye, Z; Yin, H; Yip, K; Yoo, H D; Youn, S W; Yu, J; Zeitnitz, C; Zelitch, S; Zhao, T; Zhou, B; Zhu, J; Zielinski, M; Zieminska, D; Zivkovic, L; Zutshi, V; Zverev, E G

    2009-12-04

    We present a direct measurement of the width of the W boson using the shape of the transverse mass distribution of W --> enu candidate events. Data from approximately 1 fb(-1) of integrated luminosity recorded at square root of s = 1.96 TeV by the D0 detector at the Fermilab Tevatron pp collider are analyzed. We use the same methods and data sample that were used for our recently published W boson mass measurement, except for the modeling of the recoil, which is done with a new method based on a recoil library. Our result, 2.028 +/- 0.072 GeV, is in agreement with the predictions of the standard model.

  11. Clique-width of unit interval graphs

    OpenAIRE

    Lozin, Vadim V.

    2007-01-01

    The clique-width is known to be unbounded in the class of unit interval graphs. In this paper, we show that this is a minimal hereditary class of unbounded clique-width, i.e., in every hereditary subclass of unit interval graphs the clique-width is bounded by a constant.

  12. Modelling the widths of fission observables in GEF

    Directory of Open Access Journals (Sweden)

    Schmidt K.-H.

    2013-03-01

    Full Text Available The widths of the mass distributions of the different fission channels are traced back to the probability distributions of the corresponding quantum oscillators that are coupled to the heat bath, which is formed by the intrinsic degrees of freedom of the fissioning system under the influence of pairing correlations and shell effects. Following conclusion from stochastic calculations of Adeev and Pashkevich, an early freezing due to dynamical effects is assumed. It is shown that the mass width of the fission channels in low-energy fission is strongly influenced by the zero-point motion of the corresponding quantum oscillator. The observed variation of the mass widths of the asymmetric fission channels with excitation energy is attributed to the energy-dependent properties of the heat bath and not to the population of excited states of the corresponding quantum oscillator.

  13. Stationary Size Distributions of Growing Cells with Binary and Multiple Cell Division

    Science.gov (United States)

    Rading, M. M.; Engel, T. A.; Lipowsky, R.; Valleriani, A.

    2011-10-01

    Populations of unicellular organisms that grow under constant environmental conditions are considered theoretically. The size distribution of these cells is calculated analytically, both for the usual process of binary division, in which one mother cell produces always two daughter cells, and for the more complex process of multiple division, in which one mother cell can produce 2 n daughter cells with n=1,2,3,… . The latter mode of division is inspired by the unicellular algae Chlamydomonas reinhardtii. The uniform response of the whole population to different environmental conditions is encoded in the individual rates of growth and division of the cells. The analytical treatment of the problem is based on size-dependent rules for cell growth and stochastic transition processes for cell division. The comparison between binary and multiple division shows that these different division processes lead to qualitatively different results for the size distribution and the population growth rates.

  14. The PCP pathway regulates Baz planar distribution in epithelial cells

    Science.gov (United States)

    Aigouy, Benoit; Le Bivic, André

    2016-01-01

    The localisation of apico-basal polarity proteins along the Z-axis of epithelial cells is well understood while their distribution in the plane of the epithelium is poorly characterised. Here we provide a systematic description of the planar localisation of apico-basal polarity proteins in the Drosophila ommatidial epithelium. We show that the adherens junction proteins Shotgun and Armadillo, as well as the baso-lateral complexes, are bilateral, i.e. present on both sides of cell interfaces. In contrast, we report that other key adherens junction proteins, Bazooka and the myosin regulatory light chain (Spaghetti squash) are unilateral, i.e. present on one side of cell interfaces. Furthermore, we demonstrate that planar cell polarity (PCP) and not the apical determinants Crumbs and Par-6 control Bazooka unilaterality in cone cells. Altogether, our work unravels an unexpected organisation and combination of apico-basal, cytoskeletal and planar polarity proteins that is different on either side of cell-cell interfaces and unique for the different contacts of the same cell. PMID:27624969

  15. Palindromic widths of nilpotent and wreath products

    Indian Academy of Sciences (India)

    Valeriy G Bardakov; Oleg V Bryukhanov; Krishnendu Gongopadhyay

    2017-02-01

    We prove that the nilpotent product of a set of groups $A_1, \\ldots , A_s$ has finite palindromic width if and only if the palindromic widths of $A_i$, $i = 1, \\ldots , s$, are finite. We give a new proof that the commutator width of $F_n \\wr K$ is infinite, where $F_n$ is a free group of rank $n\\geq 2$ and $K$ is a finite group. This result, combining with a result of Fink [9] gives examples of groups with infinite commutator width but finite palindromic width with respect to some generating set.

  16. Testing for the maximum cell probabilities in multinomial distributions

    Institute of Scientific and Technical Information of China (English)

    XIONG Shifeng; LI Guoying

    2005-01-01

    This paper investigates one-sided hypotheses testing for p[1], the largest cell probability of multinomial distribution. A small sample test of Ethier (1982) is extended to the general cases. Based on an estimator of p[1], a kind of large sample tests is proposed. The asymptotic power of the above tests under local alternatives is derived. An example is presented at the end of this paper.

  17. A Bio-Based Fuel Cell for Distributed Energy Generation

    Energy Technology Data Exchange (ETDEWEB)

    Anthony Terrinoni; Sean Gifford

    2008-06-30

    The technology we propose consists primarily of an improved design for increasing the energy density of a certain class of bio-fuel cell (BFC). The BFCs we consider are those which harvest electrons produced by microorganisms during their metabolism of organic substrates (e.g. glucose, acetate). We estimate that our technology will significantly enhance power production (per unit volume) of these BFCs, to the point where they could be employed as stand-alone systems for distributed energy generation.

  18. Engineered antifouling microtopographies: surface pattern effects on cell distribution.

    Science.gov (United States)

    Decker, Joseph T; Sheats, Julian T; Brennan, Anthony B

    2014-12-23

    Microtopography has been observed to lead to altered attachment behavior for marine fouling organisms; however, quantification of this phenomenon is lacking in the scientific literature. Here, we present quantitative measurement of the disruption of normal attachment behavior of the fouling algae Ulva linza by antifouling microtopographies. The distribution of the diatom Navicula incerta was shown to be unaffected by the presence of topography. The radial distribution function was calculated for both individual zoospores and cells as well as aggregates of zoospores from attachment data for a variety topographic configurations and at a number of different attachment densities. Additionally, the screening distance and maximum values were mapped according to the location of zoospore aggregates within a single unit cell. We found that engineered topographies decreased the distance between spore aggregates compared to that for a smooth control surface; however, the distributions for individual spores were unchanged. We also found that the local attachment site geometry affected the screening distance for aggregates of zoospores, with certain geometries decreasing screening distance and others having no measurable effect. The distribution mapping techniques developed and explored in this article have yielded important insight into the design parameters for antifouling microtopographies that can be implemented in the next generation of antifouling surfaces.

  19. Development of Spatial Distribution Patterns by Biofilm Cells.

    Science.gov (United States)

    Haagensen, Janus A J; Hansen, Susse K; Christensen, Bjarke B; Pamp, Sünje J; Molin, Søren

    2015-09-01

    Confined spatial patterns of microbial distribution are prevalent in nature, such as in microbial mats, soil communities, and water stream biofilms. The symbiotic two-species consortium of Pseudomonas putida and Acinetobacter sp. strain C6, originally isolated from a creosote-polluted aquifer, has evolved a distinct spatial organization in the laboratory that is characterized by an increased fitness and productivity. In this consortium, P. putida is reliant on microcolonies formed by Acinetobacter sp. C6, to which it attaches. Here we describe the processes that lead to the microcolony pattern by Acinetobacter sp. C6. Ecological spatial pattern analyses revealed that the microcolonies were not entirely randomly distributed and instead were arranged in a uniform pattern. Detailed time-lapse confocal microscopy at the single-cell level demonstrated that the spatial pattern was the result of an intriguing self-organization: small multicellular clusters moved along the surface to fuse with one another to form microcolonies. This active distribution capability was dependent on environmental factors (carbon source and oxygen) and historical contingency (formation of phenotypic variants). The findings of this study are discussed in the context of species distribution patterns observed in macroecology, and we summarize observations about the processes involved in coadaptation between P. putida and Acinetobacter sp. C6. Our results contribute to an understanding of spatial species distribution patterns as they are observed in nature, as well as the ecology of engineered communities that have the potential for enhanced and sustainable bioprocessing capacity.

  20. Cartographic system for spatial distribution analysis of corneal endothelial cells.

    Science.gov (United States)

    Corkidi, G; Márquez, J; García-Ruiz, M; Díaz-Cintra, S; Graue, E

    1994-07-01

    A combined cartographic and morphometric endothelium analyser has been developed by integrating the HISTO 2000 histological imaging and analysis system with a prototype human corneal endothelium analyser. The complete system allows the elaboration and analysis of cartographies of corneal endothelial tissue, and hence the in vitro study of the spatial distribution of corneal endothelial cells, according to their regional morphometric characteristics (cell size and polygonality). The global cartographic reconstruction is obtained by sequential integration of the data analysed for each microscopic field. Subsequently, the location of each microscopically analysed field is referred to its real position on the histologic preparation by means of X-Y co-ordinates; both are provided by micrometric optoelectronic sensors installed on the optical microscope stage. Some cartographies of an excised human corneal keratoconus button in vitro are also presented. These cartographic images allow a macroscopic view of endothelial cells analysed microscopically. Parametric colour images show the spatial distribution of endothelial cells, according to their specific morphometric parameters, and exhibit the variability in size and cellular shape which depend on the analysed area.

  1. Resonance widths in open microwave cavities studied by harmonic inversion

    OpenAIRE

    Kuhl, U; Hoehmann, R.; Main, J.; Stoeckmann, H. -J.

    2007-01-01

    From the measurement of a reflection spectrum of an open microwave cavity the poles of the scattering matrix in the complex plane have been determined. The resonances have been extracted by means of the harmonic inversion method. By this it became possible to resolve the resonances in a regime where the line widths exceed the mean level spacing up to a factor of 10, a value inaccessible in experiments up to now. The obtained experimental distributions of line widths were found to be in perfec...

  2. The width of 5-dimensional prismatoids

    CERN Document Server

    Matschke, Benjamin; Weibel, Christophe

    2012-01-01

    Santos' construction of counter-examples to the Hirsch conjecture is based on the existence of prismatoids of dimension d of width greater than d. The case d=5 being the smallest one in which this can possibly occur, we here study the width of 5-dimensional prismatoids, obtaining the following results: - There are 5-prismatoids of width six with only 25 vertices, versus the 48 vertices in Santos' original construction. This leads to lowering the dimension of the non-Hirsch polytopes from 43 to only 20. - There are 5-prismatoids with n vertices and width \\Omega(n^(1/2)) for arbitrarily large n.

  3. Approximation Algorithms for Directed Width Parameters

    CERN Document Server

    Kintali, Shiva; Kumar, Akash

    2011-01-01

    Treewidth of an undirected graph measures how close the graph is to being a tree. Several problems that are NP-hard on general graphs are solvable in polynomial time on graphs with bounded treewidth. Motivated by the success of treewidth, several directed analogues of treewidth have been introduced to measure the similarity of a directed graph to a directed acyclic graph (DAG). Directed treewidth, D-width, DAG-width, Kelly-width and directed pathwidth are some such parameters. In this paper, we present the first approximation algorithms for all these five directed width parameters. For directed treewidth and D-width we achieve an approximation factor of O(sqrt{logn}). For DAG-width, Kelly-width and directed pathwidth we achieve an O({\\log}^{3/2}{n}) approximation factor. Our algorithms are constructive, i.e., they construct the decompositions associated with these parameters. The width of these decompositions are within the above mentioned factor of the corresponding optimal width.

  4. Tissue Regeneration and Stem Cell Distribution in Adriamycin Induced Glomerulopathy

    Science.gov (United States)

    Zickri, Maha Baligh; Fattah, Marwa Mohamed Abdel; Metwally, Hala Gabr

    2012-01-01

    Background and Objectives Glomerulosclerosis develops secondary to various kidney diseases. It was postulated that adriamycin (ADR) induce chronic glomerulopathy. Treatment combinations for one year did not significantly modify renal function in resistant focal segmental glomerulosclerosis (FSGS). Recurrence of FSGS after renal transplantation impacts long-term graft survival and limits access to transplantation. The present study aimed at investigating the relation between the possible therapeutic effect of human mesenchymal stem cells (HMSCs), isolated from cord blood on glomerular damage and their distribution by using ADR induced nephrotoxicity as a model in albino rat. Methods and Results Thirty three male albino rats were divided into control group, ADR group where rats were given single intraperitoneal (IP) injection of 5 mg/kg adriamycin. The rats were sacrificed 10, 20 and 30 days following confirmation of glomerular injury. In stem cell therapy group, rats were injected with HMSCs following confirmation of renal injury and sacrificed 10, 20 and 30 days after HMSCs therapy. Kidney sections were exposed to histological, histochemical, immunohistochemical, morphometric and serological studies. In response to SC therapy multiple Malpighian corpuscles (MC) appeared with patent Bowman's space (Bs) 10 and 20 days following therapy. One month following therapy no remarkable shrunken glomeruli were evident. Glomerular area and serum creatinine were significantly different in ADR group in comparison to control and SC therapy groups. Conclusions ADR induced glomerulosclerosis regressed in response to cord blood HMSC therapy. A reciprocal relation was recorded between the extent of renal regeneration and the distribution of undifferentiated mesenchymal stem cells. PMID:24298364

  5. Wave characterization for mammalian cell culture: residence time distribution.

    Science.gov (United States)

    Rodrigues, Maria Elisa; Costa, Ana Rita; Henriques, Mariana; Azeredo, Joana; Oliveira, Rosário

    2012-02-15

    The high dose requirements of biopharmaceutical products led to the development of mammalian cell culture technologies that increase biomanufacturing capacity. The disposable Wave bioreactor is one of the most promising technologies, providing ease of operation and no cross-contamination, and using an innovative undulation movement that ensures good mixing and oxygen transfer without cell damage. However, its recentness demands further characterization. This study evaluated the residence time distribution (RTD) in Wave, allowing the characterization of mixing and flow and the comparison with ideal models and a Stirred tank reactor (STR) used for mammalian cell culture. RTD was determined using methylene blue with pulse input methodology, at three flow rates common in mammalian cell culture (3.3×10(-5)m(3)/h, 7.9×10(-5)m(3)/h, and 1.25×10(-4)m(3)/h) and one typical of microbial culture (5×10(-3)m(3)/h). Samples were taken periodically and the absorbance read at 660nm. It was observed that Wave behavior diverted from ideal models, but was similar to STR. Therefore, the deviations are not related to the particular Wave rocking mechanism, but could be associated with the inadequacy of these reactors to operate in continuous mode or to a possible inability of the theoretical models to properly describe the behavior of reactors designed for mammalian cell culture. Thus, the development of new theoretical models could better characterize the performance of these reactors.

  6. Development of Spatial Distribution Patterns by Biofilm Cells

    DEFF Research Database (Denmark)

    Haagensen, Janus Anders Juul; Hansen, Susse Kirkelund; Bak Christensen, Bjarke

    2015-01-01

    Confined spatial patterns of microbial distribution are prevalent in nature, such as in microbial mats, soil communities, and water stream biofilms. The symbiotic two-species consortium of Pseudomonas putida and Acinetobacter sp. C6, originally isolated from a creosote-polluted aquifer, has evolved...... a distinct spatial organization in the laboratory that is characterized by an increased fitness and productivity. In this consortium, P. putida is reliant on microcolonies formed by Acinetobacter sp. C6 — to which it attaches. Here we describe the processes that lead to the microcolony......-pattern by Acinetobacter sp. C6. Ecological spatial pattern analyses revealed that the microcolonies were not entirely randomly distributed, and instead arranged in a uniform pattern. Detailed time-lapse confocal microscopy at the single cell level demonstrated that the spatial pattern was the result of an intriguing self...

  7. Temperature Distribution in Solar Cells Calculated in Three Dimensional Approach

    Directory of Open Access Journals (Sweden)

    Hamdy K. Elminir

    2000-01-01

    Full Text Available Field-testing is costly, time consuming and depends heavily on prevailing weather conditions. Adequate security and weather protection must also provide at the test site. Delays can also be caused due to bad weather and system failures. To overcome these problems, a Photovoltaic (PV array simulation may be used. For system design purpose, the model must reflect the details of the physical process occurring in the cell, to get a closer insight into device operation as well as optimization of particular device parameters. PV cell temperature ratings have a great effect on the main cell performance. Hence, the need for an exact technique to calculate accurately and efficiently the temperature distribution of a PV cell arises, from which we can adjust safe and proper operation at maximum ratings. The Scope of this work is to describe the development of 3D-thermal models, which are used to update the operation temperature, to get a closer insight into the response behavior and to estimate the overall performance.

  8. Solid Oxide Fuel Cell Hybrid System for Distributed Power Generation

    Energy Technology Data Exchange (ETDEWEB)

    David Deangelis; Rich Depuy; Debashis Dey; Georgia Karvountzi; Nguyen Minh; Max Peter; Faress Rahman; Pavel Sokolov; Deliang Yang

    2004-09-30

    This report summarizes the work performed by Hybrid Power Generation Systems, LLC (HPGS) during the April to October 2004 reporting period in Task 2.3 (SOFC Scaleup for Hybrid and Fuel Cell Systems) under Cooperative Agreement DE-FC26-01NT40779 for the U. S. Department of Energy, National Energy Technology Laboratory (DOE/NETL), entitled ''Solid Oxide Fuel Cell Hybrid System for Distributed Power Generation''. This study analyzes the performance and economics of power generation systems for central power generation application based on Solid Oxide Fuel Cell (SOFC) technology and fueled by natural gas. The main objective of this task is to develop credible scale up strategies for large solid oxide fuel cell-gas turbine systems. System concepts that integrate a SOFC with a gas turbine were developed and analyzed for plant sizes in excess of 20 MW. A 25 MW plant configuration was selected with projected system efficiency of over 65% and a factory cost of under $400/kW. The plant design is modular and can be scaled to both higher and lower plant power ratings. Technology gaps and required engineering development efforts were identified and evaluated.

  9. A Niche Width Model of Optimal Specialization

    NARCIS (Netherlands)

    Bruggeman, Jeroen; Ó Nualláin, Breanndán

    2000-01-01

    Niche width theory, a part of organizational ecology, predicts whether “specialist” or “generalist” forms of organizations have higher “fitness,” in a continually changing environment. To this end, niche width theory uses a mathematical model borrowed from biology. In this paper, we first loosen th

  10. Performance of multi-junction cells due to illumination distribution across the cell surface

    Energy Technology Data Exchange (ETDEWEB)

    Schultz, R.D., E-mail: s206029578@live.nmmu.ac.za [Nelson Mandela University, Physics Department, P.O. Box 77000, 6031, Port Elizabeth (South Africa); Vorster, F.J; Dyk, E.E van [Nelson Mandela University, Physics Department, P.O. Box 77000, 6031, Port Elizabeth (South Africa)

    2012-05-15

    This paper addresses the influence of illumination distribution on the performance of a high concentration photovoltaic (HCPV) module. CPV systems comprise of optical elements as well as mechanical tracking to concentrate the solar flux onto the solar receiver as well as to keep the system on track with the sun. The performance of the subcells of the multi-junction concentrator cell depends on the optical alignment of the system. Raster scanning of the incident intensity in the optical plane of the receiver and corresponding I-V measurements were used to investigate the influence of illumination distribution on performance. The results show that the illumination distribution that differs between cells does affect the performance of the module. The performance of the subcells of the multi-junction concentrator cell also depends on the optical alignment of the system.

  11. Buried ion-exchanged glass waveguides: burial-depth dependence on waveguide width.

    Science.gov (United States)

    Madasamy, P; West, B R; Morrell, M M; Geraghty, D F; Honkanen, S; Peyghambarian, N

    2003-07-01

    A detailed theoretical and experimental study of the depth dependence of buried ion-exchanged waveguides on waveguide width is reported. Modeling, which includes the effect of nonhomogeneous time-dependent electric field distribution, agrees well with our experiments showing that burial depth increases linearly with waveguide width. These results may be used in the proper design of integrated optical circuits that need waveguides of different widths at different sections, such as arrayed waveguide gratings.

  12. Electric Field Screening by the Proximity of Two Knife-Edge Field Emitters of Finite Width

    Science.gov (United States)

    Wong, P.; Tang, W.; Lau, Y. Y.; Hoff, B.

    2015-11-01

    Field emitter arrays have the potential to provide high current density, low voltage operation, and high pulse repetition for radar and communication. It is well known that packing density of the field emitter arrays significantly affect the emission current. Previously we calculated analytically the electric field profile of two-dimensional knife-edge cathodes with arbitrary separation by using a Schwarz-Christoffel transformation. Here we extend this previous work to include the finite width of two identical emitters. From the electric field profile, the field enhancement factor, thereby the severity of the electric field screening, are determined. It is found that for two identical emitters with finite width, the magnitude of the electric field on the knife-edge cathodes depends strongly on the ratio h / a and h / r , where h is the height of the knife-edge cathode, 2a is the distance between the cathodes, and 2 r represents their width. Particle-in-cell simulations are performed to compare with the analytical results on the emission current distribution. P. Y. Wong was supported by a Directed Energy Summer Scholar internship at Air Force Research Laboratory, Kirtland AFB, and by AFRL Award No. FA9451-14-1-0374.

  13. Kinetic Simulations of the Self-Focusing and Dissipation of Finite-Width Electron Plasma Waves

    Energy Technology Data Exchange (ETDEWEB)

    Winjum, B. J. [Univ. of California, Los Angeles, CA (United States); Berger, R. L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Chapman, T. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Banks, J. W. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Brunner, S. [Federal Inst. of Technology, Lausanne (Switzerland)

    2013-09-01

    Two-dimensional simulations, both Vlasov and particle-in-cell, are presented that show the evolution of the field and electron distribution of finite-width, nonlinear electron plasma waves. The intrinsically intertwined effects of self-focusing and dissipation of field energy caused by electron trapping are studied in simulated systems that are hundreds of wavelengths long in the transverse direction but only one wavelength long and periodic in the propagation direction. From various initial wave states, both the width at focus Δm relative to the initial width Δ0 and the maximum field amplitude at focus are shown to be a function of the growth rate of the transverse modulational instability γTPMI divided by the loss rate of field energy νE to electrons escaping the trapping region. With dissipation included, an amplitude threshold for self-focusing γTPMIE~1 is found that supports the analysis of Rose [Phys. Plasmas 12, 012318 (2005)].

  14. Solid Oxide Fuel Cell Hybrid System for Distributed Power Generation

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen Minh

    2005-12-01

    This report summarizes the work performed by Hybrid Power Generation Systems, LLC (HPGS) under Cooperative Agreement DE-FC2601NT40779 for the US Department of Energy, National Energy Technology Laboratory (DoE/NETL) entitled ''Solid Oxide Fuel Cell Hybrid System for Distributed Power Generation''. The main objective of this project is to develop and demonstrate the feasibility of a highly efficient hybrid system integrating a planar Solid Oxide Fuel Cell (SOFC) and a gas turbine. A conceptual hybrid system design was selected for analysis and evaluation. The selected system is estimated to have over 65% system efficiency, a first cost of approximately $650/kW, and a cost of electricity of 8.4 cents/kW-hr. A control strategy and conceptual control design have been developed for the system. A number of SOFC module tests have been completed to evaluate the pressure impact to performance stability. The results show that the operating pressure accelerates the performance degradation. Several experiments were conducted to explore the effects of pressure on carbon formation. Experimental observations on a functioning cell have verified that carbon deposition does not occur in the cell at steam-to-carbon ratios lower than the steady-state design point for hybrid systems. Heat exchanger design, fabrication and performance testing as well as oxidation testing to support heat exchanger life analysis were also conducted. Performance tests of the prototype heat exchanger yielded heat transfer and pressure drop characteristics consistent with the heat exchanger specification. Multicell stacks have been tested and performance maps were obtained under hybrid operating conditions. Successful and repeatable fabrication of large (>12-inch diameter) planar SOFC cells was demonstrated using the tape calendering process. A number of large area cells and stacks were successfully performance tested at ambient and pressurized conditions. A 25 MW plant configuration was

  15. Static vortices in long Josephson junctions of exponentially varying width

    Science.gov (United States)

    Semerdjieva, E. G.; Boyadjiev, T. L.; Shukrinov, Yu. M.

    2004-06-01

    A numerical simulation is carried out for static vortices in a long Josephson junction with an exponentially varying width. At specified values of the parameters the corresponding boundary-value problem admits more than one solution. Each solution (distribution of the magnetic flux in the junction) is associated to a Sturm-Liouville problem, the smallest eigenvalue of which can be used, in a first approximation, to assess the stability of the vortex against relatively small spatiotemporal perturbations. The change in width of the junction leads to a renormalization of the magnetic flux in comparison with the case of a linear one-dimensional model. The influence of the model parameters on the stability of the states of the magnetic flux is investigated in detail, particularly that of the shape parameter. The critical curve of the junction is constructed from pieces of the critical curves for the different magnetic flux distributions having the highest critical currents for the given magnetic field.

  16. Spin gated GDR widths at moderate temperatures

    Directory of Open Access Journals (Sweden)

    Mukul Ish

    2015-01-01

    Full Text Available We present the evolution of giant dipole resonance (GDR width as a function of angular momentum in the compound nucleus 144Sm in the temperature range of 1.5-2.0 MeV. The high energy γ rays emitted from the decay of excited 144Sm were measured using large NaI detector in coincidence with 4π sum spin spectrometer. GDR widths were found to comply with thermal shape fluctuation model in this temperature range over a wide range of spin. Experimental widths tend to increase rapidly at high angular momentum values.

  17. Modeling thalamocortical cell: impact of Ca2+ channel distribution and cell geometry on firing pattern

    Directory of Open Access Journals (Sweden)

    Reza Zomorrodi

    2008-12-01

    Full Text Available The influence of calcium channel distribution and geometry of the thalamocortical cell upon its tonic firing and the low threshold spike (LTS generation was studied in a 3-compartment model, which represents soma, proximal and distal dendrites as well as in multi-compartment model using the morphology of a real reconstructed neuron. Using an uniform distribution of Ca2+ channels, we determined the minimal number of low threshold voltage-activated calcium channels and their permeability required for the onset of LTS in response to a hyperpolarizing current pulse. In the 3-compartment model, we found that the channel distribution influences the firing pattern only in the range of 3% below the threshold value of total T-channel density. In the multi-compartmental model, the LTS could be generated by only 64% of unequally distributed T-channels compared to the minimal number of equally distributed T-channels. For a given channel density and injected current, the tonic firing frequency was found to be inversely proportional to the size of the cell. However, when the Ca2+ channel density was elevated in soma or proximal dendrites, then the amplitude of LTS response and burst spike frequencies were determined by the ratio of total to threshold number of T-channels in the cell for a specific geometry.

  18. Modeling Thalamocortical Cell: Impact of Ca2+ Channel Distribution and Cell Geometry on Firing Pattern

    Science.gov (United States)

    Zomorrodi, Reza; Kröger, Helmut; Timofeev, Igor

    2008-01-01

    The influence of calcium channel distribution and geometry of the thalamocortical cell upon its tonic firing and the low threshold spike (LTS) generation was studied in a 3-compartment model, which represents soma, proximal and distal dendrites as well as in multi-compartment model using the morphology of a real reconstructed neuron. Using an uniform distribution of Ca2+ channels, we determined the minimal number of low threshold voltage-activated calcium channels and their permeability required for the onset of LTS in response to a hyperpolarizing current pulse. In the 3-compartment model, we found that the channel distribution influences the firing pattern only in the range of 3% below the threshold value of total T-channel density. In the multi-compartmental model, the LTS could be generated by only 64% of unequally distributed T-channels compared to the minimal number of equally distributed T-channels. For a given channel density and injected current, the tonic firing frequency was found to be inversely proportional to the size of the cell. However, when the Ca2+ channel density was elevated in soma or proximal dendrites, then the amplitude of LTS response and burst spike frequencies were determined by the ratio of total to threshold number of T-channels in the cell for a specific geometry. PMID:19129908

  19. Reduced neutron widths in the nuclear data ensemble: Experiment and theory do not agree

    CERN Document Server

    Koehler, P E

    2010-01-01

    I have analyzed reduced neutron widths ($\\Gamma_{n}^{0}$) for the subset of 1245 resonances in the nuclear data ensemble (NDE) for which they have been reported. Random matrix theory (RMT) predicts for the Gaussian orthogonal ensemble (GOE) that these widths should follow a $\\chi ^{2}$ distribution having one degree of freedom ($\

  20. Porous Alumina Films with Width-Controllable Alumina Stripes

    Directory of Open Access Journals (Sweden)

    Huang Shi-Ming

    2010-01-01

    Full Text Available Abstract Porous alumina films had been fabricated by anodizing from aluminum films after an electropolishing procedure. Alumina stripes without pores can be distinguished on the surface of the porous alumina films. The width of the alumina stripes increases proportionally with the anodizing voltage. And the pores tend to be initiated close to the alumina stripes. These phenomena can be ascribed to the electric field distribution in the alumina barrier layer caused by the geometric structure of the aluminum surface.

  1. Porous Alumina Films with Width-Controllable Alumina Stripes.

    Science.gov (United States)

    Huang, Kai; Huang, Shi-Ming; Pu, Lin; Shi, Yi; Wu, Zhi-Ming; Ji, Li; Kang, Jun-Yong

    2010-08-21

    Porous alumina films had been fabricated by anodizing from aluminum films after an electropolishing procedure. Alumina stripes without pores can be distinguished on the surface of the porous alumina films. The width of the alumina stripes increases proportionally with the anodizing voltage. And the pores tend to be initiated close to the alumina stripes. These phenomena can be ascribed to the electric field distribution in the alumina barrier layer caused by the geometric structure of the aluminum surface.

  2. Transients of Water Distribution and Transport in PEM Fuel Cells

    KAUST Repository

    Hussaini, Irfan S.

    2009-01-01

    The response of polymer electrolyte membrane (PEM) fuel cells to a step change in load is investigated experimentally in this work. Voltage undershoot, a characteristic feature of transient response following a step increase in current, is due to transients of water distribution in the membrane and ionomers occurring at subsecond time scales. The use of humidified reactants as a means to control the magnitude of voltage undershoot is demonstrated. Further, the response under a step decrease in current density is explored to determine the existence of hysteresis. Under sufficiently humidified conditions, the responses under forward and reverse step changes are symmetric, but under low relative humidity conditions, voltage undershoot is twice as large as the overshoot. © 2009 The Electrochemical Society.

  3. Distance distributions of photogenerated charge pairs in organic photovoltaic cells.

    Science.gov (United States)

    Barker, Alex J; Chen, Kai; Hodgkiss, Justin M

    2014-08-27

    Strong Coulomb interactions in organic photovoltaic cells dictate that charges must separate over relatively long distances in order to circumvent geminate recombination and produce photocurrent. In this article, we measure the distance distributions of thermalized charge pairs by accessing a regime at low temperature where charge pairs are frozen out following the primary charge separation step and recombine monomolecularly via tunneling. The exponential attenuation of tunneling rate with distance provides a sensitive probe of the distance distribution of primary charge pairs, reminiscent of electron transfer studies in proteins. By fitting recombination dynamics to distributions of recombination rates, we identified populations of charge-transfer states and well-separated charge pairs. For the wide range of materials we studied, the yield of separated charges in the tunneling regime is strongly correlated with the yield of free charges measured via their intensity-dependent bimolecular recombination dynamics at room temperature. We therefore conclude that populations of free charges are established via long-range charge separation within the thermalization time scale, thus invoking early branching between free and bound charges across an energetic barrier. Subject to assumed values of the electron tunneling attenuation constant, we estimate critical charge separation distances of ∼3-4 nm in all materials. In some blends, large fullerene crystals can enhance charge separation yields; however, the important role of the polymers is also highlighted in blends that achieved significant charge separation with minimal fullerene concentration. We expect that our approach of isolating the intrinsic properties of primary charge pairs will be of considerable value in guiding new material development and testing the validity of proposed mechanisms for long-range charge separation.

  4. On the Spectrum Width of Wind Waves

    Institute of Scientific and Technical Information of China (English)

    李陆平; 黄培基

    2001-01-01

    Based on the universal expression of wind wave spectra, four commonly used definitions of the spectrum width arere-examined. The results show that the non-dimensional spectrum width can measure the width of non-dimensionalspectra but it does not reflect the developing state of the spectra. The dimensional spectrum width expresses the degree ofconcentration of wave energy of the spectrum in the process of wind wave growth. Tests show that the spectrum widthpresented by Wen et al. can objectively measure the degree of concentration of wave energy of the spectrum, reflect thestate of wind wave growth, and provides a better result for practical application. The rules for definition of the spectrumwidth are discussed.

  5. Bipartite Graphs of Large Clique-Width

    Science.gov (United States)

    Korpelainen, Nicholas; Lozin, Vadim V.

    Recently, several constructions of bipartite graphs of large clique-width have been discovered in the literature. In the present paper, we propose a general framework for developing such constructions and use it to obtain new results on this topic.

  6. The Electrical Distribution Feed Box for the LHC Prototype Cell

    CERN Document Server

    Hauviller, Claude; Poncet, Alain; Sacré, P; Trilhe, P

    2000-01-01

    The Electrical Distribution Feed Box (DFB) for the Large Hadron Collider (LHC) Prototype Cell (String 2) is a 6 meter-long 4.6 K / 0.135 MPa liquid helium cryostat which supports and cools 13 kA and 600 A High-Temperature Superconductor (HTS) current leads. These are used for powering the String 2 main dipole and quadrupole superconducting magnets, together with their correctors. The DFB also incorporates the l-plate between its saturated liquid helium bath and the magnet pressurized superfluid helium bath at 1.9 K/ 0.13 MPa. The DFB is built within the frame of a collaboration between CERN and the Budker Institute of Nuclear Physics (Novosibirsk, Russian Federation). It is a complex cryostat satisfying a number of constraints (space available, accessibility, integration) and combining different technologies such as mechanical and electrical engineering, superconductivity, cryogenics and vacuum. The current status of the design and construction of the DFB for the LHC Prototype Cell, together with an outlook t...

  7. Distribution and differentiation of mesenchymal stem cells in tumor tissue

    Institute of Scientific and Technical Information of China (English)

    ZHAO Hai-feng; CHEN Jun; XU Zhi-shun; ZHANG Ke-qin

    2009-01-01

    Background Tumor has an ability to become enriched in mesenchymal stem cells (MSCs) and of guiding MSCs to migrate to tumor tissue. But there are lack of relevant reports on the distribution and differentiation of MSCs in tumor tissue and the effect on tumor growth after MSCs engrafted in tumor tissue. In this study, we observed the distribution of bone marrow MSCs in tumor tissue and the possibility of MSCs differentiating into myofibroblast under the induction of local tumor microenvironment.Methods Twenty-four New Zealand rabbits were randomly classified into the control group and the test group. MSCs were isolated and cultured for each animal, vx-2 tumor tissue was transplanted under the bladder mucosa of each animal. One week after the transplantation, the self F2 passage MSCs marked by 4',6-diamidino-2-phenylindole were transplanted into tumor tissue in the test group while only Dulbecco's modified Eagle's medium-low glucose was infused into the control group. Ultrasonography was performed for each animal 1,2, 3 and 4 week(s) after the vx-2 tumor mass was transplanted. The maximum bladder tumor diameter of each animal was recorded and the mean value of each group was calculated. One animal from each group was sacrificed in the third week and the remaining animals in the fourth week to observe the tumor development. Another animal treated the same as the test group was sacrificed to observe the distribution of MSCs in tumor tissue one week after self MSCs transplantation. Immunofluorescence was used to trace MSCs in tumor tissue. The double labeling immunofluorescence for α-smooth muscle actin (α-SMA) and vimentin was performed to identify whether the MSCs can differentiate into myofibroblast.Results The ultrasonography showed no tumor mass one week after the vx-2 tumor mass transplantation. The mean maximum tumor diameter of the control group and test group was (0.70±0.14) cm and (0.78±0.14) cm, respectively, and there was no significant difference (t=1

  8. Chemokine-mediated distribution of dendritic cell subsets in renal cell carcinoma

    Directory of Open Access Journals (Sweden)

    Meyer Werner

    2010-10-01

    Full Text Available Abstract Background Renal cell carcinoma (RCC represents one of the most immunoresponsive cancers. Antigen-specific vaccination with dendritic cells (DCs in patients with metastatic RCC has been shown to induce cytotoxic T-cell responses associated with objective clinical responses. Thus, clinical trials utilizing DCs for immunotherapy of advanced RCCs appear to be promising; however, detailed analyses concerning the distribution and function of DC subsets in RCCs are lacking. Methods We characterized the distribution of the different immature and mature myeloid DC subsets in RCC tumour tissue and the corresponding normal kidney tissues. In further analyses, the expression of various chemokines and chemokine receptors controlling the migration of DC subsets was investigated. Results The highest numbers of immature CD1a+ DCs were found within RCC tumour tissue. In contrast, the accumulation of mature CD83+/DC-LAMP+ DCs were restricted to the invasive margin of the RCCs. The mature DCs formed clusters with proliferating T-cells. Furthermore, a close association was observed between MIP-3α-producing tumour cells and immature CCR6+ DC recruitment to the tumour bed. Conversely, MIP-3β and SLC expression was only detected at the tumour border, where CCR7-expressing T-cells and mature DCs formed clusters. Conclusion Increased numbers of immature DCs were observed within the tumour tissue of RCCs, whereas mature DCs were found in increased numbers at the tumour margin. Our results strongly implicate that the distribution of DC subsets is controlled by local lymphoid chemokine expression. Thus, increased expression of MIP-3α favours recruitment of immature DCs to the tumour bed, whereas de novo local expression of SLC and MIP-3β induces accumulation of mature DCs at the tumour margin forming clusters with proliferating T-cells reflecting a local anti-tumour immune response.

  9. a Linear Model for Meandering Rivers with Arbitrarily Varying Width

    Science.gov (United States)

    Frascati, A.; Lanzoni, S.

    2011-12-01

    Alluvial rivers usually exhibit quite complex planforms, characterized by a wide variety of alternating bends, that have attracted the interest of a large number of researchers. Much less attention has been paid to another striking feature observed in alluvial rivers, namely the relatively regular spatial variations attained by the channel width. Actively meandering channels, in fact, generally undergo spatial oscillations systematically correlated with channel curvature, with cross sections wider at bends than at crossings. Some other streams have been observed to exhibit irregular width variations. Conversely, rivers flowing in highly vegetated flood plains, i.e. canaliform rivers, may exhibit an opposite behavior, owing to the combined effects of bank erodibility and floodplain depositional processes which, in turn, are strictly linked to vegetation cover. Similarly to streamline curvatures induced by bends, the presence of along channel width variations may have remarkable effects on the flow field and sediment dynamics and, thereby, on the equilibrium river bed configuration. In particular, spatial distribution of channel curvature typically determines the formation of a rhythmic bar-pool pattern in the channel bed strictly associated with the development of river meanders. Channel width variations are on the contrary characterized by a sequence of narrowing, yielding a central scour, alternated to the downstream development of a widening associated with the formation of a central bar. Here we present a morphodynamic model that predict at a linear level the spatial distribution of the flow field and the equilibrium bed configuration of an alluvial river characterized by arbitrary along channel distributions of both the channel axis curvature and the channel width. The mathematical model is averaged over the depth and describes the steady, non-uniform flow and sediment transport in sinuous channels with a noncohesive bed. The governing two-dimensional equations

  10. Comparison of tibiofemoral joint space width measurements from standing CT and fixed flexion radiography.

    Science.gov (United States)

    Segal, Neil A; Frick, Eric; Duryea, Jeffrey; Nevitt, Michael C; Niu, Jingbo; Torner, James C; Felson, David T; Anderson, Donald D

    2016-08-09

    The objective of this project was to determine the relationship between medial tibiofemoral joint space width measured on fixed-flexion radiographs and the three-dimensional joint space width distribution on low-dose, standing CT (SCT) imaging. At the 84-month visit of the Multicenter Osteoarthritis Study, 20 participants were recruited. A commercial SCT scanner for the foot and ankle was modified to image knees while standing. Medial tibiofemoral joint space width was assessed on radiographs at fixed locations from 15-30% of compartment width using validated software and on SCT by mapping the distances between three-dimensional subchondral bone surfaces. Individual joint space width values from radiographs were compared with three-dimensional joint space width values from corresponding sagittal plane locations using paired t-tests and correlation coefficients. For the 4 medial-most tibiofemoral locations, radiographic joint space width values exceeded the minimal joint space width on SCT by a mean of 2.0mm and were approximately equal to the 61st percentile value of the joint space width distribution at each respective sagittal-plane location. Correlation coefficients at these locations were 0.91-0.97 and the offsets between joint space width values from radiographs and SCT measurements were consistent. There were greater offsets and variability in the offsets between modalities closer to the tibial spine. Joint space width measurements on fixed-flexion radiographs are highly correlated with three-dimensional joint space width from SCT. In addition to avoiding bony overlap obscuring the joint, a limitation of radiographs, the current study supports a role for SCT in the evaluation of tibiofemoral OA. This article is protected by copyright. All rights reserved.

  11. Neurosecretory Cell Types and Distribution in Unfed Female Hyalomma Dromedari (Acari: Ixodoidea: Ixodidae) Synganglion

    Science.gov (United States)

    1987-01-01

    of the cell in subtype VIh (Fig. 2). Type IX : In these oval celo, 2 subtypes are distinguished according to cell size and NSG distribution. The NSG...1977) : Neurosecretion in Ornithodoros savignyi (Audouin) (Ixodoidea : Arga- sidae ). The distribution of neurosecretory cells in the brain. J. Vet. Res

  12. Influence of Doppler Bin Width on GNSS Detection Probabilities

    CERN Document Server

    Geiger, Bernhard C

    2011-01-01

    The acquisition stage in GNSS receivers determines Doppler shifts and code phases of visible satellites. Acquisition is thus a search in two continuous dimensions, where the digital algorithms require a partitioning of the search space into cells. We present analytic expressions for the acquisition performance depending on the partitioning of the Doppler frequency domain. In particular, the impact of the number and width of Doppler bins is analyzed. The presented results are verified by simulations.

  13. Multicellular automaticity of cardiac cell monolayers: effects of density and spatial distribution of pacemaker cells

    Science.gov (United States)

    Elber Duverger, James; Boudreau-Béland, Jonathan; Le, Minh Duc; Comtois, Philippe

    2014-11-01

    Self-organization of pacemaker (PM) activity of interconnected elements is important to the general theory of reaction-diffusion systems as well as for applications such as PM activity in cardiac tissue to initiate beating of the heart. Monolayer cultures of neonatal rat ventricular myocytes (NRVMs) are often used as experimental models in studies on cardiac electrophysiology. These monolayers exhibit automaticity (spontaneous activation) of their electrical activity. At low plated density, cells usually show a heterogeneous population consisting of PM and quiescent excitable cells (QECs). It is therefore highly probable that monolayers of NRVMs consist of a heterogeneous network of the two cell types. However, the effects of density and spatial distribution of the PM cells on spontaneous activity of monolayers remain unknown. Thus, a simple stochastic pattern formation algorithm was implemented to distribute PM and QECs in a binary-like 2D network. A FitzHugh-Nagumo excitable medium was used to simulate electrical spontaneous and propagating activity. Simulations showed a clear nonlinear dependency of spontaneous activity (occurrence and amplitude of spontaneous period) on the spatial patterns of PM cells. In most simulations, the first initiation sites were found to be located near the substrate boundaries. Comparison with experimental data obtained from cardiomyocyte monolayers shows important similarities in the position of initiation site activity. However, limitations in the model that do not reflect the complex beat-to-beat variation found in experiments indicate the need for a more realistic cardiomyocyte representation.

  14. Adherens junction distribution mechanisms during cell-cell contact elongation in Drosophila.

    Directory of Open Access Journals (Sweden)

    Gabrielle Goldenberg

    Full Text Available During Drosophila gastrulation, amnioserosa (AS cells flatten and spread as an epithelial sheet. We used AS morphogenesis as a model to investigate how adherens junctions (AJs distribute along elongating cell-cell contacts in vivo. As the contacts elongated, total AJ protein levels increased along their length. However, genetically blocking this AJ addition indicated that it was not essential for maintaining AJ continuity. Implicating other remodeling mechanisms, AJ photobleaching revealed non-directional lateral mobility of AJs along the elongating contacts, as well as local AJ removal from the membranes. Actin stabilization with jasplakinolide reduced AJ redistribution, and live imaging of myosin II along elongating contacts revealed fragmented, expanding and contracting actomyosin networks, suggesting a mechanism for lateral AJ mobility. Actin stabilization also increased total AJ levels, suggesting an inhibition of AJ removal. Implicating AJ removal by endocytosis, clathrin endocytic machinery accumulated at AJs. However, dynamin disruption had no apparent effect on AJs, suggesting the involvement of redundant or dynamin-independent mechanisms. Overall, we propose that new synthesis, lateral diffusion, and endocytosis play overlapping roles to populate elongating cell-cell contacts with evenly distributed AJs in this in vivo system.

  15. FEM Analysis of Rolling Pressure Along Strip Width in Cold Rolling Process

    Institute of Scientific and Technical Information of China (English)

    LIU Xiang-hua; SHI Xu; LI Shan-qing; XU Jian-yong; WANG Guo-dong

    2007-01-01

    Using 3-D elastic-plastic FEM, the cold strip rolling process in a 4-high mill was simulated. The elastic deformation of rolls, the plastic deformation of the strip, and the pressure between the work roll and the backup roll were taken into account. The distribution of rolling pressure along the strip width was obtained. Based on the simulation results, the peak value of rolling pressure and the location of the peak were analyzed under different rolling conditions. The effects of the roll bending force and the strip width on the distribution of rolling pressure along the width direction were determined.

  16. Width of Sunspot Generating Zone and Reconstruction of Butterfly Diagram

    CERN Document Server

    Ivanov, V G; 10.1007/s11207-010-9665-6

    2010-01-01

    Based on the extended Greenwich-NOAA/USAF catalogue of sunspot groups it is demonstrated that the parameters describing the latitudinal width of the sunspot generating zone (SGZ) are closely related to the current level of solar activity, and the growth of the activity leads to the expansion of SGZ. The ratio of the sunspot number to the width of SGZ shows saturation at a certain level of the sunspot number, and above this level the increase of the activity takes place mostly due to the expansion of SGZ. It is shown that the mean latitudes of sunspots can be reconstructed from the amplitudes of solar activity. Using the obtained relations and the group sunspot numbers by Hoyt and Schatten (1998), the latitude distribution of sunspot groups ("the Maunder butterfly diagram") for the 18th and the first half of the 19th centuries is reconstructed and compared with historical sunspot observations.

  17. A Direct Measurement of the $W$ Decay Width

    Energy Technology Data Exchange (ETDEWEB)

    Vine, Troy [Univ. of College, London (United Kingdom)

    2008-08-01

    A direct measurement of the W boson total decay width is presented in proton-antiproton collisions at √s = 1.96 TeV using data collected by the CDF II detector. The measurement is made by fitting a simulated signal to the tail of the transverse mass distribution in the electron and muon decay channels. An integrated luminosity of 350 pb-1 is used, collected between February 2002 and August 2004. Combining the results from the separate decay channels gives the decay width as 2.038 ± 0.072 GeV in agreement with the theoretical prediction of 2.093 ± 0.002 GeV. A system is presented for the management of detector calibrations using a relational database schema. A description of the implementation and monitoring of a procedure to provide general users with a simple interface to the complete set of calibrations is also given.

  18. Distribution of Prestin on Outer Hair Cell Basolateral Surface

    Institute of Scientific and Technical Information of China (English)

    YU Ning; ZHAI Suo-qiang; YANG Shi-ming; HAN Dong-yi; ZHAO Hong-bo

    2008-01-01

    Prestin has been identified as a motor protein responsible for outer hair cell (OHC) electromotility and is expressed on the OHC surface. Previous studies revealed that OHC eleetromotility and its associated nonlinear capacitance were mainly located at the OHC lateral wall and absent at the apical cutieular plate and the basal nucleus region. Immunofluorescent staining for prestin also failed to demonstrate prestin expression at the OHC basal ends in whole-mount preparation of the organ of Corti. However, there lacks a definitive demonstration of the pattern of prestin distribution. The OHC lateral wall has a trilaminate organization and is composed of the plasma membrane, cortical lattice, and subsurface cisternae. In this study, the location of prestin proteins in dissociated OHCs was examined using immunofluorescent staining and confocal microscopy. We found that prestin was uniformly expressed on the basolateral surface, including the basal pole. No staining was seen on the cuticular plate and stereocilia. When co-stained with a membrane marker di-8-ANEPPS, prestin-labeling was found to be in the outer layer of the OHC lateral wall. After separating the plasma membrane from the underlying subsurface eisternae using a hypotonic extracellular solution, prestin-labeling was found to be in the plasma membrane, not the subsurface cisternae. The data show that prestin is expressed in the plasma membrane on the entire OHC basolateral surface.

  19. Constraints on widths of mixed pentaquark multiplets

    CERN Document Server

    Mohta, V

    2004-01-01

    We determine constraints on the partial widths of mixed pentaquark multiplets in the framework of heavy baryon chiral perturbation theory (HB$\\chi$PT). The partial widths satisfy a GMO-type relation at leading order in HB$\\chi$PT, for arbitrary mixing. The widths of N(1440), N(1710), and $\\Theta(1540)$ are not consistent with ideal mixing, $\\theta_{N} = 35.3^{\\circ}$, but are consistent with $\\theta_{N} \\lesssim 25^{\\circ}$. Furthermore, there are parameter values in HB$\\chi$PT that produce such a mixing angle while allowing the identification of the mass spectrum above. As an alternative to non-ideal mixing, we also suggest reasons for giving up on N(1440) as a pure pentaquark state.

  20. The Variable Line Width of Achernar

    CERN Document Server

    Rivinius, Th; Baade, D; Carciofi, A C; Leister, N; Štefl, S

    2016-01-01

    Spectroscopic observations of Achernar over the past decades, have shown the photospheric line width, as measured by the rotational parameter $v \\sin i$, to vary in correlation with the emission activity. Here we present new observations, covering the most recent activity phase, and further archival data collected from the archives. The $v \\sin i$ variation is confirmed. On the basis of the available data it cannot be decided with certainty whether the increased line width precedes the emission activity, i.e. is a signature of the ejection mechanism, or postdates is, which would make it a signature of re-accretion of some of the disk-material. However, the observed evidence leans towards the re-accretion hypothesis. Two further stars showing the effect of variable line width in correlation with emission activity, namely 66 Oph and $\\pi$ Aqr, are presented as well.

  1. Graph Operations on Clique-Width Bounded Graphs

    OpenAIRE

    Gurski, Frank

    2007-01-01

    Clique-width is a well-known graph parameter. Many NP-hard graph problems admit polynomial-time solutions when restricted to graphs of bounded clique-width. The same holds for NLC-width. In this paper we study the behavior of clique-width and NLC-width under various graph operations and graph transformations. We give upper and lower bounds for the clique-width and NLC-width of the modified graphs in terms of the clique-width and NLC-width of the involved graphs.

  2. Line width of Josephson flux flow oscillators

    DEFF Research Database (Denmark)

    Koshelets, V.P.; Dmitriev, P.N.; Sobolev, A.S.;

    2002-01-01

    to be proven before one initiates real FFO applications. To achieve this goal a comprehensive set of line width measurements of the FFO operating in different regimes has been performed. FFOs with tapered shape have been successfully implemented in order to avoid the superfine resonant structure with voltage...... spacing of about 20 nV and extremely low differential resistance, recently observed in the IVC of the standard rectangular geometry. The obtained results have been compared with existing theories and FFO models in order to understand and possibly eliminate excess noise in the FFO. The intrinsic line width...

  3. Estimation of current density distribution of PAFC by analysis of cell exhaust gas

    Energy Technology Data Exchange (ETDEWEB)

    Kato, S.; Seya, A. [Fuji Electric Co., Ltd., Ichihara-shi (Japan); Asano, A. [Fuji Electric Corporate, Ltd., Yokosuka-shi (Japan)

    1996-12-31

    To estimate distributions of Current densities, voltages, gas concentrations, etc., in phosphoric acid fuel cell (PAFC) stacks, is very important for getting fuel cells with higher quality. In this work, we leave developed a numerical simulation tool to map out the distribution in a PAFC stack. And especially to Study Current density distribution in the reaction area of the cell, we analyzed gas composition in several positions inside a gas outlet manifold of the PAFC stack. Comparing these measured data with calculated data, the current density distribution in a cell plane calculated by the simulation, was certified.

  4. Statistical characteristics of Doppler spectral width as observed by the conjugate SuperDARN radars

    Directory of Open Access Journals (Sweden)

    K. Hosokawa

    Full Text Available We performed a statistical analysis of the occurrence distribution of Doppler spectral width around the day-side high-latitude ionosphere using data from the conjugate radar pair composed of the CUTLASS Iceland-East radar in the Northern Hemisphere and the SENSU Syowa-East radar in the Southern Hemisphere. Three types of spectral width distribution were identified: (1 an exponential-like distribution in the lower magnetic latitudes (below 72°, (2 a Gaussian-like distribution around a few degrees magnetic latitude, centered on 78°, and (3 another type of distribution in the higher magnetic latitudes (above 80°. The first two are considered to represent the geophysical regimes such as the LLBL and the cusp, respectively, because they are similar to the spectral width distributions within the LLBL and the cusp, as classified by Baker et al. (1995. The distribution found above 80° magnetic latitude has been clarified for the first time in this study. This distribution has similarities to the exponential-like distribution in the lower latitude part, although clear differences also exist in their characteristics. These three spectral width distributions are commonly identified in conjugate hemispheres. The latitudinal transition from one distribution to another exhibits basically the same trend between two hemispheres. There is, however, an interhemispheric difference in the form of the distribution around the cusp latitudes, such that spectral width values obtained from Syowa-East are larger than those from Iceland-East. On the basis of the spectral width characteristics, the average locations of the cusp and the open/closed field line boundary are estimated statistically.

    Key words. Ionosphere (ionosphere-magnetosphere inter-actions; plasma convection – Magnetospheric physics (magnetopause, cusp, and boundary layers

  5. Correlation Widths in Quantum--Chaotic Scattering

    OpenAIRE

    Dietz, B.; Richter, A; WeidenmÜller, H.

    2011-01-01

    An important parameter to characterize the scattering matrix S for quantum-chaotic scattering is the width Gamma_{corr} of the S-matrix autocorrelation function. We show that the "Weisskopf estimate" d/(2pi) sum_c T_c (where d is the mean resonance spacing, T_c with 0

  6. Regulation of Cell Adhesion Strength by Peripheral Focal Adhesion Distribution

    OpenAIRE

    2011-01-01

    Cell adhesion to extracellular matrices is a tightly regulated process that involves the complex interplay between biochemical and mechanical events at the cell-adhesive interface. Previous work established the spatiotemporal contributions of adhesive components to adhesion strength and identified a nonlinear dependence on cell spreading. This study was designed to investigate the regulation of cell-adhesion strength by the size and position of focal adhesions (FA). The cell-adhesive interfac...

  7. Spatial concentration distribution analysis of cells in electrode-multilayered microchannel by dielectric property measurement.

    Science.gov (United States)

    Yao, Jiafeng; Kodera, Tatsuya; Obara, Hiromichi; Sugawara, Michiko; Takei, Masahiro

    2015-07-01

    The spatial concentration distribution of cells in a microchannel is measured by combining the dielectric properties of cells with the specific structure of the electrode-multilayered microchannel. The dielectric properties of cells obtained with the impedance spectroscopy method includes the cell permittivity and dielectric relaxation, which corresponds to the cell concentration and structure. The electrode-multilayered microchannel is constructed by 5 cross-sections, and each cross-section contains 5 electrode-layers embedded with 16 micro electrodes. In the experiment, the dielectric properties of cell suspensions with different volume concentrations are measured with different electrode-combinations corresponding to different electric field distributions. The dielectric relaxations of different cell concentrations are compared and discussed with the Maxwell-Wagner dispersion theory, and the relaxation frequencies are analysed by a cell polarization model established based on the Hanai cell model. Moreover, a significant linear relationship with AC frequency dependency between relative permittivity and cell concentration was found, which provides a promising way to on-line estimate cell concentration in microchannel. Finally, cell distribution in 1 cross-section of the microchannel (X and Y directions) was measured with different electrode-combinations using the dielectric properties of cell suspensions, and cell concentration distribution along the microchannel (Z direction) was visualized at flowing state. The present cell spatial sensing study provides a new approach for 3 dimensional non-invasive online cell sensing for biological industry.

  8. Pulse width control loop as a duty cycle corrector

    Directory of Open Access Journals (Sweden)

    Jovanović Goran

    2004-01-01

    Full Text Available The clock distribution and generation circuitry forms a critical component of current synchronous digital systems. A digital system’s clocks must have not only low jitter, low skew, but also well-controlled duty cycle in order to facilitate versatile clocking techniques. In high-speed CMOS clock buffer design, the duty cycle of a clock is liable to be changed when the clock passes through a multistage buffer because the circuit is not pure digital [8]. In this paper, we propose a pulse width control loop referred as MPWCL (modified pulse width control loop that adopts the same architecture as the conventional PWCL, but with a new pulse generator and new charge pump circuit as a constituent of the duty cycle detector. Thanks to using new building blocks the proposed pulse width control loop can control the duty cycle in a wide range, and what is more important it becomes operative in saturation region too, what provides conditional for fast locking time. For 1.2 µm double-metal double-poly CMOS process with Vdd = 5 V and operating frequency of 133 MHz, results of SPICE simulation show that the duty cycle can be well controlled in the range from 20 % up to 80 % if the loop parameters are properly chosen.

  9. Predictors of the peak width for networks with exponential links

    Science.gov (United States)

    Troutman, B.M.; Karlinger, M.R.

    1989-01-01

    We investigate optimal predictors of the peak (S) and distance to peak (T) of the width function of drainage networks under the assumption that the networks are topologically random with independent and exponentially distributed link lengths. Analytical results are derived using the fact that, under these assumptions, the width function is a homogeneous Markov birth-death process. In particular, exact expressions are derived for the asymptotic conditional expectations of S and T given network magnitude N and given mainstream length H. In addition, a simulation study is performed to examine various predictors of S and T, including N, H, and basin morphometric properties; non-asymptotic conditional expectations and variances are estimated. The best single predictor of S is N, of T is H, and of the scaled peak (S divided by the area under the width function) is H. Finally, expressions tested on a set of drainage basins from the state of Wyoming perform reasonably well in predicting S and T despite probable violations of the original assumptions. ?? 1989 Springer-Verlag.

  10. Channel width dependence of electrical characteristics of a-Si:H TFTs under bending stresses

    Science.gov (United States)

    Oh, Hyungon; Cho, Kyoungah; Kim, Sangsig

    2017-04-01

    In this study, we investigate the electrical characteristics of bendable a-Si:H thin-film transistors (TFTs) with various channel widths as a function of bending stress. Compared with a narrower channel TFT, a wider channel TFT exhibits a stable performance even at a bending strain of 1.3%. Our stress and strain distribution analysis reveals an inverse relationship between the channel width and the channel stress. As the channel width widens from 8 to 50 μm, the stress experienced by the middle channel region decreases from 545 to 277 MPa. Moreover, a 50 μm-channel-width TFT operates stably even after a 15 000 bending cycle while the 8 μm-channel-width TFT fails to operate after a 2000 bending cycle.

  11. Method of producing ceramic distribution members for solid state electrolyte cells

    Science.gov (United States)

    Clark, Douglas J. (Inventor); Galica, Leo M. (Inventor); Losey, Robert W. (Inventor); Suitor, Jerry W. (Inventor)

    1995-01-01

    A solid state electrolyte cells apparatus and method of producing is disclosed. The apparatus can be used for separating oxygen from an oxygen-containing feedstock or as a fuel cell for reacting fluids. Cells can be stacked so that fluids can be introduced and removed from the apparatus through ceramic distribution members having ports designed for distributing the fluids in parallel flow to and from each cell. The distribution members can also serve as electrodes to membranes or as membrane members between electrodes, The distribution member design does not contain any horizontal internal ports which allows the member to be thin. A method of tape casting in combination with an embossing method allows intricate radial ribs and bosses to be formed on each distribution member. The bosses serve as seals for the ports and allow the distribution members to be made without any horizontal internal ports.

  12. Regulation of cell adhesion strength by peripheral focal adhesion distribution.

    Science.gov (United States)

    Elineni, Kranthi Kumar; Gallant, Nathan D

    2011-12-21

    Cell adhesion to extracellular matrices is a tightly regulated process that involves the complex interplay between biochemical and mechanical events at the cell-adhesive interface. Previous work established the spatiotemporal contributions of adhesive components to adhesion strength and identified a nonlinear dependence on cell spreading. This study was designed to investigate the regulation of cell-adhesion strength by the size and position of focal adhesions (FA). The cell-adhesive interface was engineered to direct FA assembly to the periphery of the cell-spreading area to delineate the cell-adhesive area from the cell-spreading area. It was observed that redistributing the same adhesive area over a larger cell-spreading area significantly enhanced cell-adhesion strength, but only up to a threshold area. Moreover, the size of the peripheral FAs, which was interpreted as an adhesive patch, did not directly govern the adhesion strength. Interestingly, this is in contrast to the previously reported functional role of FAs in regulating cellular traction where sizes of the peripheral FAs play a critical role. These findings demonstrate, to our knowledge for the first time, that two spatial regimes in cell-spreading area exist that uniquely govern the structure-function role of FAs in regulating cell-adhesion strength.

  13. New algorithm and system for measuring size distribution of blood cells

    Institute of Scientific and Technical Information of China (English)

    Cuiping Yao(姚翠萍); Zheng Li(李政); Zhenxi Zhang(张镇西)

    2004-01-01

    In optical scattering particle sizing, a numerical transform is sought so that a particle size distribution can be determined from angular measurements of near forward scattering, which has been adopted in the measurement of blood cells. In this paper a new method of counting and classification of blood cell, laser light scattering method from stationary suspensions, is presented. The genetic algorithm combined with nonnegative least squared algorithm is employed to inverse the size distribution of blood cells. Numerical tests show that these techniques can be successfully applied to measuring size distribution of blood cell with high stability.

  14. Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions.

    Science.gov (United States)

    Werner, Benjamin; Beier, Fabian; Hummel, Sebastian; Balabanov, Stefan; Lassay, Lisa; Orlikowsky, Thorsten; Dingli, David; Brümmendorf, Tim H; Traulsen, Arne

    2015-10-15

    We investigate the in vivo patterns of stem cell divisions in the human hematopoietic system throughout life. In particular, we analyze the shape of telomere length distributions underlying stem cell behavior within individuals. Our mathematical model shows that these distributions contain a fingerprint of the progressive telomere loss and the fraction of symmetric cell proliferations. Our predictions are tested against measured telomere length distributions in humans across all ages, collected from lymphocyte and granulocyte sorted telomere length data of 356 healthy individuals, including 47 cord blood and 28 bone marrow samples. We find an increasing stem cell pool during childhood and adolescence and an approximately maintained stem cell population in adults. Furthermore, our method is able to detect individual differences from a single tissue sample, i.e. a single snapshot. Prospectively, this allows us to compare cell proliferation between individuals and identify abnormal stem cell dynamics, which affects the risk of stem cell related diseases.

  15. Nanoparticle Distributions in Cancer and other Cells from Light Transmission Spectroscopy

    Science.gov (United States)

    Deatsch, Alison; Sun, Nan; Johnson, Jeffery; Stack, Sharon; Tanner, Carol; Ruggiero, Steven

    We have measured the optical properties of whole cells and lysates using light transmission spectroscopy (LTS). LTS provides both the optical extinction coefficient in the wavelength range from 220 to 1100 nm and (by spectral inversion using a Mie model) the particle distribution density in the size range from 1 to 3000 nm. Our current work involves whole cells and lysates of cultured human oral cells and other plant and animal cells. We have found systematic differences in the optical extinction between cancer and normal whole cells and lysates, which translate to different particle size distributions (PSDs) for these materials. We have also found specific power-law dependences of particle density with particle diameter for cell lysates. This suggests a universality of the packing distribution in cells that can be compared to ideal Apollonian packing, with the cell modeled as a fractal body comprised of spheres on all size scales.

  16. Exotic Meson Decay Widths using Lattice QCD

    CERN Document Server

    Cook, M S

    2006-01-01

    A decay width calculation for a hybrid exotic meson h, with JPC=1-+, is presented for the channel h->pi+a1. This quenched lattice QCD simulation employs Luescher's finite box method. Operators coupling to the h and pi+a1 states are used at various levels of smearing and fuzzing, and at four quark masses. Eigenvalues of the corresponding correlation matrices yield energy spectra that determine scattering phase shifts for a discrete set of relative pi+a1 momenta. Although the phase shift data is sparse, fits to a Breit-Wigner model are attempted, resulting in a decay width of about 60 MeV when averaged over two lattice sizes.

  17. W mass and width at the LHC.

    CERN Document Server

    Malberti, Martina

    2006-01-01

    The precision measurement of the W boson properties, such as its mass and width, constitutes an important consistency check of the Standard Model. This paper, in particular, describes methods to measure the W mass with improved precision at the Large Hadron Collider, exploiting the large number of Z bosons produced. The precision on the W boson mass achievable with an integrated luminosisty of 10~fb^-1 is discussed.

  18. Measuring skewness of red blood cell deformability distribution by laser ektacytometry

    Energy Technology Data Exchange (ETDEWEB)

    Nikitin, S Yu; Priezzhev, A V; Lugovtsov, A E [International Laser Center, M. V. Lomonosov Moscow State University, Moscow (Russian Federation); Ustinov, V D [M. V. Lomonosov Moscow State University, Faculty of Computational Mathematics and Cybernetics, Moscow (Russian Federation)

    2014-08-31

    An algorithm is proposed for measuring the parameters of red blood cell deformability distribution based on laser diffractometry of red blood cells in shear flow (ektacytometry). The algorithm is tested on specially prepared samples of rat blood. In these experiments we succeeded in measuring the mean deformability, deformability variance and skewness of red blood cell deformability distribution with errors of 10%, 15% and 35%, respectively. (laser biophotonics)

  19. Distribution of P2Y receptor subtypes on haematopoietic cells

    OpenAIRE

    1998-01-01

    RT–PCR-southern hybridization analyses with radiolabelled P2Y receptor cDNAs as probes indicated that the peripheral blood leukocytes and the human umbilical vein endothelial cells express P2Y1, P2Y2, P2Y4 and P2Y6 receptors.Of the haematopoietic cell lines tested, promonocytic U937 cells express P2Y2 and P2Y6, but not P2Y1 or P2Y4; promyelocytic HL-60 cells express the P2Y1, P2Y2 and P2Y6 receptors but not the P2Y4 receptor; K562 cells express P2Y1 but not P2Y2, P2Y4 or P2Y6; and Dami cells ...

  20. Microsecond pulse width, intense, light-ion beam accelerator

    Science.gov (United States)

    Rej, D. J.; Bartsch, R. R.; Davis, H. A.; Faehl, R. J.; Greenly, J. B.; Waganaar, W. J.

    1993-10-01

    A relatively long-pulse width (0.1-1 μs) intense ion beam accelerator has been built for materials processing applications. An applied Br, magnetically insulated extraction ion diode with dielectric flashover ion source is installed directly onto the output of a 1.2 MV, 300-kJ Marx generator. The diode is designed with the aid of multidimensional particle-in-cell simulations. Initial operation of the accelerator at 0.4 MV indicates satisfactory performance without the need for additional pulse shaping. The effect of a plasma opening switch on diode behavior is considered.

  1. Development of Spatial Distribution Patterns by Biofilm Cells

    DEFF Research Database (Denmark)

    Haagensen, Janus Anders Juul; Hansen, Susse Kirkelund; Bak Christensen, Bjarke;

    2015-01-01

    in the context of species distribution patterns observed in macroecology, and we summarize observations about the processes involved in co-adaptation between P. putida and Acinetobacter sp. C6. Our results contribute to an understanding of spatial species distribution patterns as they are observed in nature......Confined spatial patterns of microbial distribution are prevalent in nature, such as in microbial mats, soil communities, and water stream biofilms. The symbiotic two-species consortium of Pseudomonas putida and Acinetobacter sp. C6, originally isolated from a creosote-polluted aquifer, has evolved...... a distinct spatial organization in the laboratory that is characterized by an increased fitness and productivity. In this consortium, P. putida is reliant on microcolonies formed by Acinetobacter sp. C6 — to which it attaches. Here we describe the processes that lead to the microcolony...

  2. Effects of Exterior Abscisic Acid on Calcium Distribution of Mesophyll Cells and Calcium Concentration of Guard Cells in Maize Seedlings

    Institute of Scientific and Technical Information of China (English)

    GUO Xiu-lin; MA Yuan-yuan; LIU Zi-hui; LIU Bin-hui

    2008-01-01

    In this study, the direct effects of exterior abscisic acid (ABA) on both calcium distribution of mesophyll cells and cytosolic calcium concentration of guard cells were examined. The distribution of Ca2+ localization were observed with calcium antimonate precipitate-electromicroscopic-cyto-chemical methods after treated with ABA and pretreated with ethylene glycol-bis-(2-aminoethylether)-N,N,N',N'-tetraacetic acid (EGTA), verapamil (Vp), and trifluoperazine (TFP). The laser scanning confocal microscopy was used to measure the cytosolic calcium concentrations of guard cells under different treatments. The results showed that the cytosolic Ca2+ concentration of mesophyll cells was induced to increase by ABA, but to decrease in both outside cell and the vacuoles within 10 min after treatments. The cytosolic calcium concentration of guard cells was increased gradually with the lag in treatment time. However, both EGTA and TFP could inverse those effects, indicating that the increase of cytosolic calcium induced by exterior ABA was mainly caused by calcium influx. The results also showed that calmodulin could influence both the calcium distribution of mesophyll cells and calcium concentration of guard cells. It shows that calmodulin participates in the process of ABA signal transduction, but the mechanism is not known as yet. The changes both calcium distribution of mesophyll cells and calcium concentration of guard cells further proved that the variations of cytosolic Ca2+ concentration induced by ABA were involved in the stomatal movements of maize seedlings.

  3. Level and width statistics of the open many-body systems

    Science.gov (United States)

    Mizutori, Shoujirou; Aiba, Hirokazu

    2016-06-01

    The level and width statistics of the two kinds of the random matrix models coupled to the continuum are analyzed. In the first model, the gaussian orthogonal ensemble with random couplings to the continuum, not only the width statistics deviate from the Porter-Thomas distribution due to the super-radiant mechanism, but also the distribution of the nearest neighbor level spacings shows deviation from the Wigner one simultaneously. In the second model, the two body random ensemble with correlated couplings to the continuum, the correlation between the target and the compound states leads to the global energy dependence of the widths. Within the narrow energy interval where states with widths deviating from the global energy dependence lie, the distributions behave similar way with the case of the random couplings. Namely, the deviation of statistics of the nearest neighbor level spacings from the Wigner distribution and the deviation of the width statistics from the Porter-Thomas distribution take place simultaneously within the models we investigated.

  4. Retinal Ganglion Cell Distribution and Spatial Resolving Power in Deep-Sea Lanternfishes (Myctophidae)

    KAUST Repository

    De Busserolles, Fanny

    2014-01-01

    Topographic analyses of retinal ganglion cell density are very useful in providing information about the visual ecology of a species by identifying areas of acute vision within the visual field (i.e. areas of high cell density). In this study, we investigated the neural cell distribution in the ganglion cell layer of a range of lanternfish species belonging to 10 genera. Analyses were performed on wholemounted retinas using stereology. Topographic maps were constructed of the distribution of all neurons and both ganglion and amacrine cell populations in 5 different species from Nissl-stained retinas using cytological criteria. Amacrine cell distribution was also examined immunohistochemically in 2 of the 5 species using anti-parvalbumin antibody. The distributions of both the total neuron and the amacrine cell populations were aligned in all of the species examined, showing a general increase in cell density toward the retinal periphery. However, when the ganglion cell population was topographically isolated from the amacrine cell population, which comprised up to 80% of the total neurons within the ganglion cell layer, a different distribution was revealed. Topographic maps of the true ganglion cell distribution in 18 species of lanternfishes revealed well-defined specializations in different regions of the retina. Different species possessed distinct areas of high ganglion cell density with respect to both peak density and the location and/or shape of the specialized acute zone (i.e. elongated areae ventro-temporales, areae temporales and large areae centrales). The spatial resolving power was calculated to be relatively low (varying from 1.6 to 4.4 cycles per degree), indicating that myctophids may constitute one of the less visually acute groups of deep-sea teleosts. The diversity in retinal specializations and spatial resolving power within the family is assessed in terms of possible ecological functions and evolutionary history.

  5. Artifacts for Calibration of Submicron Width Measurements

    Science.gov (United States)

    Grunthaner, Frank; Grunthaner, Paula; Bryson, Charles, III

    2003-01-01

    Artifacts that are fabricated with the help of molecular-beam epitaxy (MBE) are undergoing development for use as dimensional calibration standards with submicron widths. Such standards are needed for calibrating instruments (principally, scanning electron microscopes and scanning probe microscopes) for measuring the widths of features in advanced integrated circuits. Dimensional calibration standards fabricated by an older process that involves lithography and etching of trenches in (110) surfaces of single-crystal silicon are generally reproducible to within dimensional tolerances of about 15 nm. It is anticipated that when the artifacts of the present type are fully developed, their critical dimensions will be reproducible to within 1 nm. These artifacts are expected to find increasing use in the semiconductor-device and integrated- circuit industries as the width tolerances on semiconductor devices shrink to a few nanometers during the next few years. Unlike in the older process, one does not rely on lithography and etching to define the critical dimensions. Instead, one relies on the inherent smoothness and flatness of MBE layers deposited under controlled conditions and defines the critical dimensions as the thicknesses of such layers. An artifact of the present type is fabricated in two stages (see figure): In the first stage, a multilayer epitaxial wafer is grown on a very flat substrate. In the second stage, the wafer is cleaved to expose the layers, then the exposed layers are differentially etched (taking advantage of large differences between the etch rates of the different epitaxial layer materials). The resulting structure includes narrow and well-defined trenches and a shelf with thicknesses determined by the thicknesses of the epitaxial layers from which they were etched. Eventually, it should be possible to add a third fabrication stage in which durable, electronically inert artifacts could be replicated in diamondlike carbon from a master made by

  6. Clique Cover Width and Clique Sum

    OpenAIRE

    Shahrokhi, Farhad

    2015-01-01

    For a clique cover $C$ in the undirected graph $G$, the clique cover graph of $C$ is the graph obtained by contracting the vertices of each clique in $C$ into a single vertex. The clique cover width of G, denoted by $CCW(G)$, is the minimum value of the bandwidth of all clique cover graphs of $G$. When $G$ is the clique sum of $G_1$ and $G_2$, we prove that $CCW(G) \\le 3/2(CCW(G_1) + CCW(G_2))$.

  7. Uneven distribution of NG2 cells in the rat cerebellar vermis and changes in aging

    Directory of Open Access Journals (Sweden)

    S. Lomoio

    2012-06-01

    Full Text Available We describe by NG2 (neuron-glia chondroitin sulphate proteoglycan 2 immunocytochemistry an uneven distribution of NG2 glial cells in the rat cerebellum, being them more represented in the central lobules of the cerebellar vermis, belonging to the cerebrocerebellum. The cerebellar distribution of NG2 cells changes in aging rats, in which the area where the cells appear to be densely scattered throughout all cerebellar layers involves also more rostral and caudal lobules. In addition, in aging rats, in the most rostral and caudal lobules belonging to the spinocerebellum, punctate reaction product is present at the apical pole of Purkinje cells, i.e. in the area where the majority of synapses between olivary climbing fibers and Purkinje cells occur. Data suggest that the different distribution of NG2 cells is correlated to differences in physiology among cerebellar areas and reflects changes during aging.

  8. Uneven distribution of NG2 cells in the rat cerebellar vermis and changes in aging

    Science.gov (United States)

    Lomoio, S.; Necchi, D.; Scherini, E.

    2012-01-01

    We describe by NG2 (neuron-glia chondroitin sulphate proteoglycan 2) immunocytochemistry an uneven distribution of NG2 glial cells in the rat cerebellum, being them more represented in the central lobules of the cerebellar vermis, belonging to the cerebrocerebellum. The cerebellar distribution of NG2 cells changes in aging rats, in which the area where the cells appear to be densely scattered throughout all cerebellar layers involves also more rostral and caudal lobules. In addition, in aging rats, in the most rostral and caudal lobules belonging to the spinocerebellum, punctate reaction product is present at the apical pole of Purkinje cells, i.e. in the area where the majority of synapses between olivary climbing fibers and Purkinje cells occur. Data suggest that the different distribution of NG2 cells is correlated to differences in physiology among cerebellar areas and reflects changes during aging. PMID:23027343

  9. Effect of passage number on electrophoretic mobility distributions of cultured human embryonic kidney cells

    Science.gov (United States)

    Kunze, M. E.

    1985-01-01

    A systematic investigation was undertaken to characterize population shifts that occur in cultured human embryonic kidney cells as a function of passage number in vitro after original explantation. This approach to cell population shift analysis follows the suggestion of Mehreshi, Klein and Revesz that perturbed cell populations can be characterized by electrophoretic mobility distributions if they contain subpopulations with different electrophoretic mobilities. It was shown that this is the case with early passage cultured human embryo cells.

  10. Optical antennas with sinusoidal modulation in width.

    Science.gov (United States)

    Dikken, Dirk Jan; Segerink, Frans B; Korterik, Jeroen P; Pfaff, Stefan S; Prangsma, Jord C; Herek, Jennifer L

    2016-08-08

    Small metal structures sustaining plasmon resonances in the optical regime are of great interest due to their large scattering cross sections and ability to concentrate light to subwavelength volumes. In this paper, we study the dipolar plasmon resonances of optical antennas with a constant volume and a sinusoidal modulation in width. We experimentally show that by changing the phase of the width-modulation, with a small 10 nm modulation amplitude, the resonance shifts over 160 nm. Using simulations we show how this simple design can create resonance shifts greater than 600 nm. The versatility of this design is further shown by creating asymmetric structures with two different modulation amplitudes, which we experimentally and numerically show to give rise to two resonances. Our results on both the symmetric and asymmetric antennas show the capability to control the localization of the fields outside the antenna, while still maintaining the freedom to change the antenna resonance wavelength. The antenna design we tested combines a large spectral tunability with a small footprint: all the antenna dimensions are factor 7 to 13 smaller than the wavelength, and hold potential as a design element in meta-surfaces for beam shaping.

  11. Gpr125 modulates Dishevelled distribution and planar cell polarity signaling.

    Science.gov (United States)

    Li, Xin; Roszko, Isabelle; Sepich, Diane S; Ni, Mingwei; Hamm, Heidi E; Marlow, Florence L; Solnica-Krezel, Lilianna

    2013-07-01

    During vertebrate gastrulation, Wnt/planar cell polarity (PCP) signaling orchestrates polarized cell behaviors underlying convergence and extension (C&E) movements to narrow embryonic tissues mediolaterally and lengthen them anteroposteriorly. Here, we have identified Gpr125, an adhesion G protein-coupled receptor, as a novel modulator of the Wnt/PCP signaling system. Excess Gpr125 impaired C&E movements and the underlying cell and molecular polarities. Reduced Gpr125 function exacerbated the C&E and facial branchiomotor neuron (FBMN) migration defects of embryos with reduced Wnt/PCP signaling. At the molecular level, Gpr125 recruited Dishevelled to the cell membrane, a prerequisite for Wnt/PCP activation. Moreover, Gpr125 and Dvl mutually clustered one another to form discrete membrane subdomains, and the Gpr125 intracellular domain directly interacted with Dvl in pull-down assays. Intriguingly, Dvl and Gpr125 were able to recruit a subset of PCP components into membrane subdomains, suggesting that Gpr125 may modulate the composition of Wnt/PCP membrane complexes. Our study reveals a role for Gpr125 in PCP-mediated processes and provides mechanistic insight into Wnt/PCP signaling.

  12. Global Distribution of Businesses Marketing Stem Cell-Based Interventions.

    Science.gov (United States)

    Berger, Israel; Ahmad, Amina; Bansal, Akhil; Kapoor, Tanvir; Sipp, Douglas; Rasko, John E J

    2016-08-04

    A structured search reveals that online marketing of stem-cell-based interventions is skewed toward developed economies including the United States, Ireland, Australia, and Germany. Websites made broad, imprecise therapeutic claims and frequently failed to detail procedures. Widespread marketing poses challenges to regulators, bioethicists, and those seeking realistic hope from therapies.

  13. Distribution of ghrelin-ike immunoreactive cells in amphioxus, Branchiostoma belcheri- A study of immunohistochemistry

    Institute of Scientific and Technical Information of China (English)

    You-Zhu Weng; Hai-Xia Song; Yong-Qiang Fang

    2008-01-01

    The distribution of ghrelin-like immunoreactive cells in amphioxus (Branchiostoma belcheri) was investigated by using immunohisto-chemical staining with rabbit antiserum against synthetical mammalian ghrelin. The results showed that ghrelin-like immunoreactive cells were distributed widely in the nervous system, Hatschek's pit, wheel organ, digestive tract and gonads (ovary and testis). In nervous system, ghrelin-like immunoreactive neurons and their protrusions were distributed specifically on the dorsal side, ventral side and funnel part of brain vesicle, with a few dispersive immunoreactive nerve cells and their fibers in nerve tube. Ghrelin-like immunoreactivities were also detected in Hatschek's pit epithelial cells and wheel organ cells, with positive substance located along cell membrane. In digestive tract, ghrelin-like immunoreactive cells existed in hepatic diverticulum, anterior and posterior region of midgut, and could be classified into two types, closed- and opened-type endocrine cells. The number of positive cells was most in hepatic diverticulum, secondary in posterior region of midgut and least in anterior region of midgut. In gonads, ghrelin-like immunoreactive substance was detected in oogonia, oocytes and follicle cells in ovary at the small and large growth stages and in early spermatogenic cells and Sertoli cells in testis. The extensive distribution of ghrelin-like cells in amphioxus suggested that these kinds of cells are conservative in evolution and diversified in function. At the same time, we found for the first time that ghrelin-like immunoreactive cells existed in brain vesicle and Hatschek's pit, which provided new morphological evidence for the existence of an activation pathway between brain vesicle and Hatschek's pit for the regulation of growth hormone excretion.

  14. A mathematical model of the current density distribution in electrochemical cells - AUTHORS’ REVIEW

    Directory of Open Access Journals (Sweden)

    PREDRAG M. ŽIVKOVIĆ

    2011-06-01

    Full Text Available An approach based on the equations of electrochemical kinetics for the estimation of the current density distribution in electrochemical cells is presented. This approach was employed for a theoretical explanation of the phenomena of the edge and corner effects. The effects of the geometry of the system, the kinetic parameters of the cathode reactions and the resistivity of the solution are also discussed. A procedure for a complete analysis of the current distribution in electrochemical cells is presented.

  15. Solid oxide fuel cell systems with hot zones having improved reactant distribution

    Energy Technology Data Exchange (ETDEWEB)

    Poshusta, Joseph C.; Booten, Charles W.; Martin, Jerry L.

    2016-05-17

    A Solid Oxide Fuel Cell (SOFC) system having a hot zone with a center cathode air feed tube for improved reactant distribution, a CPOX reactor attached at the anode feed end of the hot zone with a tail gas combustor at the opposing end for more uniform heat distribution, and a counter-flow heat exchanger for efficient heat retention.

  16. Device-width dependence of plateau width in quantum Hall states

    Science.gov (United States)

    Kawaji, S.; Hirakawa, K.; Nagata, M.

    1993-02-01

    Hall bar type devices having a total length of 2900 μm, a source and drain electrode width of 400 μm and different widths w ranging from 10 to 120 μm in its central 600 μm long part are fabricated from a GaAs/AlGaAs wafer with electron mobility of 21 m 2V -1s -1. The current at which the quantum Hall plateau for i=2 at B=9.7T at T=1.2K disappears is proportional to w. The average critical current density is Jcr=(1.6±0.2) A m -1

  17. Pulse width effect on the dissociation probability of CH4+ in the intense femtosecond laser field

    Institute of Scientific and Technical Information of China (English)

    WANG Gao; SONG Di; LIU Yuyan; KONG Fan'ao

    2006-01-01

    The laser pulse width effect on the dissociation probability of CH4+ irradiated by an ultrafast laser has been investigated experimentally and theoretically. The femtosecond laser at 800 nm with an intensity of 8.0 × 1013 W/cm2 was used. The observed relative yield of the primary fragment ion CH3+ increases with increasing pulse width and tends to saturate when the pulse width is longer than 120 fs. The field-assisted dissociation (FAD) model and quasi-classical trajectory (QCT) calculation were applied to predicting the dissociation probability of CH4+.The calculated probability is corrected with the molecular orientation effect and the spatial distribution of laser intensity. The modified results show that the dissociation requires at least 23 fs and saturates with long pulse widths (≥100 rs). The result is approximately consistent with the experimental observation.

  18. Cesarean section imprints cord blood immune cell distributions

    DEFF Research Database (Denmark)

    Thysen, Anna Hammerich; Larsen, Jeppe Madura; Rasmussen, Mette Annelie;

    2014-01-01

    Immune programming in early life may affect the risk of developing immune-related diseases later in life. Children born by cesarean section seem to be at higher risk of asthma, allergic rhinitis, and type-1 diabetes. We hypothesized that delivery by cesarean section may affect immune maturation...... in newborns. The objective of the study was to profile innate and adaptive immune cell subsets in cord blood of children born by cesarean section or natural birth....

  19. Distribution of K and L cells in the feline intestinal tract.

    Science.gov (United States)

    Gilor, C; Gilor, S; Graves, T K; Borst, L B; Labelle, P; Ridge, T K; Santoro, D; Dossin, O

    2013-07-01

    Glucose-dependent insulinotropic peptide (GIP), glucagon-like peptide (GLP)-1 and GLP-2 are hormones secreted from specialized K cells (GIP) and L cells (GLP-1, GLP-2) in the intestinal mucosa. These hormones play major roles in health and disease by modulating insulin secretion, satiety, and multiple intestinal functions. The aim of this study was to describe the distribution of K cells and L cells in the intestines of healthy cats. Samples of duodenum, mid-jejunum, ileum, cecum, and colon were collected from 5 cats that were euthanized for reasons unrelated to this study and had no gross or histologic evidence of gastrointestinal disease. Samples stained with rabbit-anti-porcine GIP, mouse-anti-(all mammals) GLP-1, or rabbit-anti-(all mammals) GLP-2 antibodies were used to determine the number of cells in 15 randomly selected 400× microscopic fields. In contrast to other mammals (eg, dogs) in which K cells are not present in the ileum and aborally, GIP-expressing cells are abundant throughout the intestines in cats (>6/high-power field in the ileum). Cells expressing GLP-1 or GLP-2 were most abundant in the ileum (>9/high-power field) as in other mammals, but, although GLP-1-expressing cells were abundant throughout the intestines, GLP-2-expressing cells were rarely found in the duodenum. In conclusion, the distribution of GIP-secreting K cells in cats is different from the distribution of K cells that is described in other mammals. The difference in distribution of GLP-2- and GLP-1-expressing cells suggests that more than 1 distinct population of L cells is present in cats.

  20. Prediction of concentrated flow width in ephemeral gully channels

    Science.gov (United States)

    Nachtergaele, J.; Poesen, J.; Sidorchuk, A.; Torri, D.

    2002-07-01

    Empirical prediction equations of the form W = aQb have been reported for rills and rivers, but not for ephemeral gullies. In this study six experimental data sets are used to establish a relationship between channel width (W, m) and flow discharge (Q, m3 s-1) for ephemeral gullies formed on cropland. The resulting regression equation (W = 2·51 Q0·412; R2 = 0·72; n = 67) predicts observed channel width reasonably well. Owing to logistic limitations related to the respective experimental set ups, only relatively small runoff discharges (i.e. Q flow channels revealed that the discharge exponent (flow shear stress distribution over the wetted perimeter between rills, gullies and rivers, (ii) a decrease in probability of a channel formed in soil material with uniform erosion resistance from rills over gullies to rivers and (iii) a decrease in average surface slope from rills over gullies to rivers.material. For both cases observed flow on cropland. For the frozen soils the equation

  1. Analysis of a stochastic model for bacterial growth and the lognormality in the cell-size distribution

    CERN Document Server

    Yamamoto, Ken

    2016-01-01

    This paper theoretically analyzes a phenomenological stochastic model for bacterial growth. This model comprises cell divisions and linear growth of cells, where growth rates and cell cycles are drawn from lognormal distributions. We derive that the cell size is expressed as a sum of independent lognormal variables. We show numerically that the quality of the lognormal approximation greatly depends on the distributions of the growth rate and cell cycle. Furthermore, we show that actual parameters of the growth rate and cell cycle take values which give good lognormal approximation, so the experimental cell-size distribution is in good agreement with a lognormal distribution.

  2. Distribution and characterization of progenitor cells within the human filum terminale.

    Directory of Open Access Journals (Sweden)

    Lisa Arvidsson

    Full Text Available BACKGROUND: Filum terminale (FT is a structure that is intimately associated with conus medullaris, the most caudal part of the spinal cord. It is well documented that certain regions of the adult human central nervous system contains undifferentiated, progenitor cells or multipotent precursors. The primary objective of this study was to describe the distribution and progenitor features of this cell population in humans, and to confirm their ability to differentiate within the neuroectodermal lineage. METHODOLOGY/PRINCIPAL FINDINGS: We demonstrate that neural stem/progenitor cells are present in FT obtained from patients treated for tethered cord. When human or rat FT-derived cells were cultured in defined medium, they proliferated and formed neurospheres in 13 out of 21 individuals. Cells expressing Sox2 and Musashi-1 were found to outline the central canal, and also to be distributed in islets throughout the whole FT. Following plating, the cells developed antigen profiles characteristic of astrocytes (GFAP and neurons (β-III-tubulin. Addition of PDGF-BB directed the cells towards a neuronal fate. Moreover, the cells obtained from young donors shows higher capacity for proliferation and are easier to expand than cells derived from older donors. CONCLUSION/SIGNIFICANCE: The identification of bona fide neural progenitor cells in FT suggests a possible role for progenitor cells in this extension of conus medullaris and may provide an additional source of such cells for possible therapeutic purposes. Filum terminale, human, progenitor cells, neuron, astrocytes, spinal cord.

  3. Energy system analysis of fuel cells and distributed generation

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; Lund, Henrik

    2007-01-01

    on the energy system in which they are used. Consequently, coherent energy systems analyses of specific and complete energy systems must be conducted in order to evaluate the benefits of FC technologies and in order to be able to compare alternative solutions. In relation to distributed generation, FC...... can be used for such analyses. Moreover, the chapter presents the results of evaluating the overall system fuel savings achieved by introducing different FC applications into different energy systems. Natural gas-based and hydrogen-based micro FC-CHP, natural gas local FC-CHP plants for district...... technologies have different strengths and weaknesses in different energy systems, but often they do not have the expected effect. Specific analyses of each individual country must be conducted including scenarios of expansion of e.g. wind power in order to evaluate where and when the best use of FC...

  4. Effects of Different Zinc Species on Cellar Zinc Distribution, Cell Cycle, Apoptosis and Viability in MDAMB231 Cells.

    Science.gov (United States)

    Wang, Yan-hong; Zhao, Wen-jie; Zheng, Wei-juan; Mao, Li; Lian, Hong-zhen; Hu, Xin; Hua, Zi-chun

    2016-03-01

    Intracellular metal elements exist in mammalian cells with the concentration range from picomoles per litre to micromoles per litre and play a considerable role in various biological procedures. Element provided by different species can influence the availability and distribution of the element in a cell and could lead to different biological effects on the cell's growth and function. Zinc as an abundant and widely distributed essential trace element, is involved in numerous and relevant physiological functions. Zinc homeostasis in cells, which is regulated by metallothioneins, zinc transporter/SLC30A, Zrt-/Irt-like proteins/SLC39A and metal-response element-binding transcription factor-1 (MTF-1), is crucial for normal cellular functioning. In this study, we investigated the influences of different zinc species, zinc sulphate, zinc gluconate and bacitracin zinc, which represented inorganic, organic and biological zinc species, respectively, on cell cycle, viability and apoptosis in MDAMB231 cells. It was found that the responses of cell cycle, apoptosis and death to different zinc species in MDAMB231 cells are different. Western blot analysis of the expression of several key proteins in regulating zinc-related transcription, cell cycle, apoptosis, including MTF-1, cyclin B1, cyclin D1, caspase-8 and caspase-9 in treated cells further confirmed the observed results on cell level.

  5. Spectral Distribution of Transport Operator Arising in Growing Cell Populations

    Directory of Open Access Journals (Sweden)

    Hongxing Wu

    2014-01-01

    Full Text Available Transport equation with partly smooth boundary conditions arising in growing cell populations is studied in Lp  (1

  6. Phenotype Clustering of Breast Epithelial Cells in Confocal Imagesbased on Nuclear Protein Distribution Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Long, Fuhui; Peng, Hanchuan; Sudar, Damir; Levievre, Sophie A.; Knowles, David W.

    2006-09-05

    Background: The distribution of the chromatin-associatedproteins plays a key role in directing nuclear function. Previously, wedeveloped an image-based method to quantify the nuclear distributions ofproteins and showed that these distributions depended on the phenotype ofhuman mammary epithelial cells. Here we describe a method that creates ahierarchical tree of the given cell phenotypes and calculates thestatistical significance between them, based on the clustering analysisof nuclear protein distributions. Results: Nuclear distributions ofnuclear mitotic apparatus protein were previously obtained fornon-neoplastic S1 and malignant T4-2 human mammary epithelial cellscultured for up to 12 days. Cell phenotype was defined as S1 or T4-2 andthe number of days in cultured. A probabilistic ensemble approach wasused to define a set of consensus clusters from the results of multipletraditional cluster analysis techniques applied to the nucleardistribution data. Cluster histograms were constructed to show how cellsin any one phenotype were distributed across the consensus clusters.Grouping various phenotypes allowed us to build phenotype trees andcalculate the statistical difference between each group. The resultsshowed that non-neoplastic S1 cells could be distinguished from malignantT4-2 cells with 94.19 percent accuracy; that proliferating S1 cells couldbe distinguished from differentiated S1 cells with 92.86 percentaccuracy; and showed no significant difference between the variousphenotypes of T4-2 cells corresponding to increasing tumor sizes.Conclusion: This work presents a cluster analysis method that canidentify significant cell phenotypes, based on the nuclear distributionof specific proteins, with high accuracy.

  7. Carotenoid distribution in living cells of Haematococcus pluvialis (Chlorophyceae.

    Directory of Open Access Journals (Sweden)

    Aaron M Collins

    Full Text Available Haematococcus pluvialis is a freshwater unicellular green microalga belonging to the class Chlorophyceae and is of commercial interest for its ability to accumulate massive amounts of the red ketocarotenoid astaxanthin (3,3'-dihydroxy-β,β-carotene-4,4'-dione. Using confocal Raman microscopy and multivariate analysis, we demonstrate the ability to spectrally resolve resonance-enhanced Raman signatures associated with astaxanthin and β-carotene along with chlorophyll fluorescence. By mathematically isolating these spectral signatures, in turn, it is possible to locate these species independent of each other in living cells of H. pluvialis in various stages of the life cycle. Chlorophyll emission was found only in the chloroplast whereas astaxanthin was identified within globular and punctate regions of the cytoplasmic space. Moreover, we found evidence for β-carotene to be co-located with both the chloroplast and astaxanthin in the cytosol. These observations imply that β-carotene is a precursor for astaxanthin and the synthesis of astaxanthin occurs outside the chloroplast. Our work demonstrates the broad utility of confocal Raman microscopy to resolve spectral signatures of highly similar chromophores in living cells.

  8. Carotenoid Distribution in Living Cells of Haematococcus pluvialis (Chlorophyceae)

    Energy Technology Data Exchange (ETDEWEB)

    Collins, Aaron M.; Jones, Howland D. T.; Han, Danxiang; Hu, Qiang; Beechem, Thomas E.; Timlin, Jerilyn A.; Evens, Terence

    2011-09-06

    Haematococcus pluvialis is a freshwater unicellular green microalga belonging to the class Chlorophyceae and is of commercial interest for its ability to accumulate massive amounts of the red ketocarotenoid astaxanthin (3,3'-dihydroxy-β,β-carotene-4,4'-dione). Using confocal Raman microscopy and multivariate analysis, we demonstrate the ability to spectrally resolve resonance–enhanced Raman signatures associated with astaxanthin and β-carotene along with chlorophyll fluorescence. By mathematically isolating these spectral signatures, in turn, it is possible to locate these species independent of each other in living cells of H. pluvialis in various stages of the life cycle. Chlorophyll emission was found only in the chloroplast whereas astaxanthin was identified within globular and punctate regions of the cytoplasmic space. Moreover, we found evidence for β-carotene to be co-located with both the chloroplast and astaxanthin in the cytosol. These observations imply that β-carotene is a precursor for astaxanthin and the synthesis of astaxanthin occurs outside the chloroplast. Finally, our work demonstrates the broad utility of confocal Raman microscopy to resolve spectral signatures of highly similar chromophores in living cells.

  9. Lake Basin Fetch and Maximum Length/Width

    Data.gov (United States)

    Minnesota Department of Natural Resources — Linear features representing the Fetch, Maximum Length and Maximum Width of a lake basin. Fetch, maximum length and average width are calcuated from the lake polygon...

  10. Pulse-Width Jitter Measurement for Laser Diode Pulses

    Institute of Scientific and Technical Information of China (English)

    TANG Jun-Hua; WANG Yun-Cai

    2006-01-01

    @@ Theoretical analysis and experimental measurement of pulse-width jitter of diode laser pulses are presented. The expression of pulse power spectra with all amplitude jitter, timing jitter and pulse-width jitter is deduced.

  11. Tissue distribution and engraftment of human mesenchymal stem cells immortalized by human telomerase reverse transcriptase gene

    DEFF Research Database (Denmark)

    Bentzon, J F; Stenderup, K; Hansen, F D

    2005-01-01

    Engraftment of mesenchymal stem cells (MSC) in peripheral tissues for replenishing of local stem cell function has been proposed as a therapeutic approach to degenerative diseases. We have previously reported the development of an immortalized human telomerase reverse transcriptase transduced MSC...... line (hMSC-TERT). In the present study, we co-transduced hMSC-TERT with enhanced green fluorescent protein gene, and studied tissue distribution, engraftment, and cell survival after intracardiac and intravenous injections in immunodeficient mice. The pattern of organ distribution suggested...... that infused cells were efficiently arrested in microvasculature during first-pass, but only for a fraction of the infused cells was arrest followed by vascular emigration and tissue engraftment. Few engrafted cells in lungs, heart, and kidney glomeruli remained after 4 weeks. These observations are consistent...

  12. Precision measurement of the mass and width of the W boson at CDF

    Energy Technology Data Exchange (ETDEWEB)

    Malik, Sarah Alam [Univ. College London, Bloomsbury (United Kingdom)

    2009-09-01

    A precision measurement of the mass and width of the W boson is presented. The W bosons are produced in proton antiproton collisions occurring at a centre of mass energy of 1.96 TeV at the Tevatron accelerator. The data used for the analyses is collected by the Collider Detector at Fermilab (CDF) and corresponds to an average integrated luminosity of 350 pb-1 for the W width analysis for the electron and muon channels and an average integrated luminosity of 2350 pb-1 for the W mass analysis. The mass and width of the W boson is extracted by fitting to the transverse mass distribution, with the peak of the distribution being most sensitive to the mass and the tail of the distribution sensitive to the width. The W width measurement in the electron and muon channels is combined to give a final result of 2032 ± 73 MeV. The systematic uncertainty on the W mass from the recoil of the W boson against the initial state gluon radiation is discussed. A systematic study of the recoil in Z → e+e- events where one electron is reconstructed in the central calorimeter and the other in the plug calorimeter and its effect on the W mass is presented for the first time in this thesis.

  13. Intrinsic potential of cell membranes: opposite effects of lipid transmembrane asymmetry and asymmetric salt ion distribution

    DEFF Research Database (Denmark)

    Gurtovenko, Andrey A; Vattulainen, Ilpo

    2009-01-01

    Using atomic-scale molecular dynamics simulations, we consider the intrinsic cell membrane potential that is found to originate from a subtle interplay between lipid transmembrane asymmetry and the asymmetric distribution of monovalent salt ions on the two sides of the cell membrane. It turns out......Cl saline solution and the PE leaflet is exposed to KCl, the outcome is that the effects of asymmetric lipid and salt ion distributions essentially cancel one another almost completely. Overall, our study highlights the complex nature of the intrinsic potential of cell membranes under physiological...

  14. Engineered nanomaterial uptake and tissue distribution: from cell to organism

    Directory of Open Access Journals (Sweden)

    Kettiger H

    2013-08-01

    Full Text Available Helene Kettiger,1,* Angela Schipanski,2,* Peter Wick,2 Jörg Huwyler1 1Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, Basel, Switzerland; 2Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Materials-Biology Interactions, St Gallen, Switzerland *These authors contributed equally to this work Abstract: Improved understanding of interactions between nanoparticles and biological systems is needed to develop safety standards and to design new generations of nanomaterials. This article reviews the molecular mechanisms of cellular uptake of engineered nanoparticles, their intracellular fate, and their distribution within an organism. We have reviewed the available literature on the uptake and disposition of engineered nanoparticles. Special emphasis was placed on the analysis of experimental systems and their limitations with respect to their usefulness to predict the in vivo situation. The available literature confirms the need to study particle characteristics in an environment that simulates the situation encountered in biological systems. Phenomena such as protein binding and opsonization are of prime importance since they may have a strong impact on cellular internalization, biodistribution, and immunogenicity of nanoparticles in vitro and in vivo. Extrapolation from in vitro results to the in vivo situation in the whole organism remains a challenge. However, improved understanding of physicochemical properties of engineered nanoparticles and their influence on biological systems facilitates the design of nanomaterials that are safe, well tolerated, and suitable for diagnostic or therapeutic use in humans. Keywords: biodistribution, cellular transport, cellular uptake, endocytosis, engineered nanomaterials, nanosafety

  15. Distribution of Th17 cells and Th1 cells in peripheral blood and cerebrospinal fluid in chronic inflammatory demyelinating polyradiculoneuropathy.

    Science.gov (United States)

    Chi, Li Jun; Xu, Wan Hai; Zhang, Zong Wen; Huang, Hui Tao; Zhang, Li Ming; Zhou, Jin

    2010-12-01

    Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated demyelinating disease of the peripheral nervous system. Th17 and Th1 cells contribute to the pathogenesis of most autoimmune diseases, but little is known about their distribution and reciprocal relationship in CIDP. In this study, we analyzed the distribution of Th17, Th1, and Th17/Th1 cells in the peripheral blood and cerebrospinal fluid (CSF). The results showed that the frequency of Th17 cells was significantly higher in the peripheral blood mononuclear cell (PBMCs) and CSF of active CIDP in comparison with remitting CIDP or to other non-inflammatory neurological diseases (ONDs), accompanied by similar findings for Th17/Th1 cells. Both active and remitting CIDP have higher percentage of Th1 cells in the CSF than OND. CSF protein levels positively correlated with the frequencies of Th17 cells either in the PBMCs or CSF of active CIDP, while there was no significant correlation with Th1 cells. In line with these observations, the levels of interleukin-17 (IL-17) in plasma and transcript factors retinoic acid receptor-related orphan receptor (ROR)γt expressed by PBMCs were significantly higher in the active CIDP than remitting CIDP or OND. In summary, our preliminary findings suggest that elevated numbers of inflammatory T cells, especially for Th17 cells, might be an important determinant in the evolution of CIDP.

  16. Is biologic width of anterior and posterior teeth similar?

    Directory of Open Access Journals (Sweden)

    Amir Alireza Rasouli Ghahroudi

    2014-09-01

    Full Text Available The biologic width (BW includes attached epithelial cells and connective tissue attachment complex being very important in the periodontal health during prosthetic treatments as invading this zone can cause bone resorption and gingival recession. The present study investigated biologic width values in the normal periodontium in anterior and posterior teeth. 30 patients that referred from restorative department to periodontics department of Tehran University of medical sciences who need crown lengthening procedure on their teeth with no history of orthodontic, prosthodontic and periodontal treatment were randomly enrolled in this cross-sectional trial. Sulcus depths (SD as well as the distance between free gingival margin and the bone crest (FB of anterior and posterior teeth were measured by UNC-15 probe and compared. periodontium thickness was also assessed. The data were subjected to Student t test. Mean BW in the 43 anterior and 47 posterior teeth was measured and not significantly different (1.4651±0.39 mm vs. 1.6312±0.49 mm was observed; however, BW was significantly more in the teeth with thick periodontium compared to those with thin periodontium (1.703±0.5 vs. 1.408±0.35; P=0.002. BW not only is different in individuals but also could be dissimilar in different teeth and should be calculated independently prior to restorative treatments.

  17. Changing step width alters lower extremity biomechanics during running.

    Science.gov (United States)

    Brindle, Richard A; Milner, Clare E; Zhang, Songning; Fitzhugh, Eugene C

    2014-01-01

    Step width is a spatiotemporal parameter that may influence lower extremity biomechanics at the hip and knee joint. The purpose of this study was to determine the biomechanical response of the lower extremity joints to step width changes during running. Lower extremity data from 30 healthy runners, half of them male, were collected during running in three step width conditions: preferred, wide, and narrow. Dependent variables and step width were analyzed using a mixed model ANOVA and pairwise t-tests for post hoc comparisons. Step width was successfully altered in the wide and narrow conditions. Generally, frontal plane peak values decreased as step width increased from narrow to preferred to wide. Peak hip adduction and rearfoot eversion angles decreased as step width increased from narrow to wide. Peak knee abduction moment and knee abduction impulse also decreased as step width increased from narrow to wide. Although men and women ran differently, gender only influenced the effect of step width on peak rearfoot inversion moment. In conclusion, step width influences lower extremity biomechanics in healthy runners. When step width increased from narrow to wide, peak values of frontal plane variables decreased. In addition to previously reported changes at the rearfoot, the hip and knee joint biomechanics were also influenced by changes in step width.

  18. MIRO1 influences the morphology and intracellular distribution of mitochondria during embryonic cell division in Arabidopsis.

    Science.gov (United States)

    Yamaoka, Shohei; Nakajima, Masaki; Fujimoto, Masaru; Tsutsumi, Nobuhiro

    2011-02-01

    Regulating the morphology and intracellular distribution of mitochondria is essential for embryo development in animals. However, the importance of such regulation is not clearly defined in plants. The evolutionarily conserved Miro proteins are known to be involved in the regulation of mitochondrial morphology and motility. We previously demonstrated that MIRO1, an Arabidopsis thaliana orthologue of the Miro protein, is required for embryogenesis. An insertional mutation in the MIRO1 gene causes arrest of embryonic cell division, leading to abortion of the embryo at an early stage. Here we investigated the role of MIRO1 in the regulation of mitochondrial behaviour in egg cells and early-stage embryos using GFP-labeled mitochondria. Two-photon laser scanning microscopy revealed that, in miro1 mutant egg cells, mitochondria are abnormally enlarged, although egg cell formation is nearly unaffected. After fertilization and subsequent zygotic cell division, the homozygous miro1 mutant two-celled embryo contained a significantly reduced number of mitochondria in its apical cell compared with the wild type, suggesting that the miro1 mutation inhibits proper intracellular distribution of mitochondria, leading to an arrest of embryonic cell division. Our findings suggest that proper mitochondrial morphology and intracellular distribution are maintained by MIRO1 and are vital for embryonic cell division.

  19. The Average Widths and Non-linear Widths of the Classes of Multivariate Functions with Bounded Moduli of Smoothness

    Institute of Scientific and Technical Information of China (English)

    Yong-ping Liu; Gui-qiao Xu

    2002-01-01

    The classes of the multivariate functions with bounded moduli on Rd and Td are given and their average a-widths and non-linear n-widths are discussed. The weak asymptotic behaviors are established for the corresponding quantities.

  20. A new low-voltage-driven GRIN liquid crystal lens with multiple ring electrodes in unequal widths.

    Science.gov (United States)

    Kao, Yung-Yuan; Chao, Paul C-P; Hsueh, Chieh-Wen

    2010-08-30

    This work is dedicated to design a novel liquid crystal (LC) lens device with multiple ring electrodes in unequal widths, in order to offer tunability on focusing quality and to lower the level of applied voltage. The number and widths of the multiple ring electrodes are pre-designed and optimized to offer the on-line tunability on individual electrode voltages to render a better refraction index distribution for focusing, as compared to the past hole-type LC lenses. The resulted refractive index distribution is expected to offer similar focusing effects based on the theory of the gradient refraction index (GRIN) lens. The transparent electrodes of this new LC lens are placed at the inner surface of the LC cell to minimize the driving voltages, in results, less than 10 V, for the same level of focusing power and an easy practical operation. A new fabrication process in the wafer level to bury bus lines is developed for generating smooth electrical fields over the lens aperture. In addition, a dielectric layer is coated between electrodes and the LC layer.

  1. Dynamic measurement of fluorescent proteins spectral distribution on virus infected cells

    Science.gov (United States)

    Lee, Ja-Yun; Wu, Ming-Xiu; Kao, Chia-Yun; Wu, Tzong-Yuan; Hsu, I.-Jen

    2006-09-01

    We constructed a dynamic spectroscopy system that can simultaneously measure the intensity and spectral distributions of samples with multi-fluorophores in a single scan. The system was used to monitor the fluorescence distribution of cells infected by the virus, which is constructed by a recombinant baculoviruses, vAcD-Rhir-E, containing the red and green fluorescent protein gene that can simultaneously produce dual fluorescence in recombinant virus-infected Spodoptera frugiperda 21 cells (Sf21) under the control of a polyhedrin promoter. The system was composed of an excitation light source, a scanning system and a spectrometer. We also developed an algorithm and fitting process to analyze the pattern of fluorescence distribution of the dual fluorescence produced in the recombinant virus-infected cells. All the algorithm and calculation are automatically processed in a visualized scanning program and can monitor the specific region of sample by calculating its intensity distribution. The spectral measurement of each pixel was performed at millisecond range and the two dimensional distribution of full spectrum was recorded within several seconds. We have constructed a dynamic spectroscopy system to monitor the process of virus-infection of cells. The distributions of the dual fluorescence were simultaneously measured at micrometer resolution.

  2. Modeling the Effects of Solar Cell Attitude Distribution on Optical Cross Section for Solar Panel Simulations

    Science.gov (United States)

    Feirstine, K.; Bush, K.; Crosher, C.; Klein, M.; Bowers, D.; Wellems, D.; Duggin, M.; Vaughn, L.

    2012-09-01

    The Air Force Research Laboratory (AFRL) Time-domain Analysis Simulation for Advanced Tracking (TASAT) was used to explore the variation of Optical Cross Section (OCS) with glint angle for a solar panel with different solar cell attitude distribution statistics. Simulations were conducted using a 3D model of a solar panel with various solar cell tip and tilt distribution statistics. Modeling a solar panel as a single sheet of "solar cell" material is not appropriate for OCS glint studies. However, modeling each individual solar cell on the panel, the tips and tilts of which come from a distribution of specified statistics (distribution type, mean, and standard deviation), accurately captures the solar panel OCS with glint angle. The objective of the simulations was to vary the glint measurement angle about the maximum glint position of the solar panel and observe the variations in OCS with angle for a bi-static illumination condition. OCS was calculated relative to the simulated scattering of a Spectralon material in the glint orientation. Results show the importance of solar cell attitude distribution statistics in modeling the OCS observed for a solar panel.

  3. SOL Width Scaling in the MAST Tokamak

    Science.gov (United States)

    Ahn, Joon-Wook; Counsell, Glenn; Connor, Jack; Kirk, Andrew

    2002-11-01

    Target heat loads are determined in large part by the upstream SOL heat flux width, Δ_h. Considerable effort has been made in the past to develop analytical and empirical scalings for Δh to allow reliable estimates to be made for the next-step device. The development of scalings for a large spherical tokamak (ST) such as MAST is particularly important both for development of the ST concept and for improving the robustness of scalings derived for conventional tokamaks. A first such scaling has been developed in MAST DND plasmas. The scaling was developed by flux-mapping data from the target Langmuir probe arrays to the mid-plane and fitting to key upstream parameters such as P_SOL, bar ne and q_95. In order to minimise the effects of co-linearity, dedicated campaigns were undertaken to explore the widest possible range of each parameter while keeping the remainder as fixed as possible. Initial results indicate a weak inverse dependence on P_SOL and approximately linear dependence on bar n_e. Scalings derived from consideration of theoretical edge transport models and integration with data from conventional devices is under way. The established scaling laws could be used for the extrapolations to the future machine such as Spherical Tokamak Power Plant (STPP). This work is jointly funded by Euratom and UK Department of Trade and Industry. J-W. Ahn would like to recognise the support of a grant from the British Foreign & Commonwealth Office.

  4. Effects of podocin transfection on CD2AP distribution in HEK293 cells

    Institute of Scientific and Technical Information of China (English)

    Yugen SHA; Songming HUANG; Aihua ZHANG; Fei ZHAO; Ronghua CHEN

    2008-01-01

    The aim of this paper is to construct a podocin fluorescence expression vector and observe the effects of podocin transfection on CD2AP distribution in HEK293 cells. The pGEMT-easy vector containing the full-length cDNA encoding human podocin was cloned and digested with BamHI and XhoI. The digested full-length podocin was subcloned into pEGFP-C2. The constructed plas-mids were transfected into HEK293 cells and its effects on CD2AP distribution were observed by immunofluo-rescence. The pEGFP-NPHS2 expression vector was successfully constructed and podocin exclusively located on the HEK293 cell membrane. After podocin transfec-tion, CD2AP redistributed from the perinucleus to the cytoplasm in HEK293 cells. It can be concluded that podocin can recruit CD2AP to redistribute from the perinucleus to the cytoplasm in HEK293 cells.

  5. Characterization of plasma-induced cell membrane permeabilization: focus on OH radical distribution

    Science.gov (United States)

    Sasaki, Shota; Honda, Ryosuke; Hokari, Yutaro; Takashima, Keisuke; Kanzaki, Makoto; Kaneko, Toshiro

    2016-08-01

    Non-equilibrium atmospheric-pressure plasma (APP) is used medically for plasma-induced cell permeabilization. However, how plasma irradiation specifically triggers permeabilization remains unclear. In an attempt to identify the dominant factor(s), the distribution of plasma-produced reactive species was investigated, primarily focusing on OH radicals. A stronger plasma discharge, which produced more OH radicals in the gas phase, also produced more OH radicals in the liquid phase (OHaq), enhancing the cell membrane permeability. In addition, plasma irradiation-induced enhancement of cell membrane permeability decreased markedly with increased solution thickness (<1 mm), and the plasma-produced OHaq decayed in solution (diffusion length on the order of several hundred micrometers). Furthermore, the horizontally center-localized distribution of OHaq corresponded with the distribution of the permeabilized cells by plasma irradiation, while the overall plasma-produced oxidizing species in solution (detected by iodine-starch reaction) exhibited a doughnut-shaped horizontal distribution. These results suggest that OHaq, among the plasma-produced oxidizing species, represents the dominant factor in plasma-induced cell permeabilization. These results enhance the current understanding of the mechanism of APP as a cell-permeabilization tool.

  6. [Calcium distribution in the egg cell, zygote and proembryo of lettuce (Lactuca sativa L.)].

    Science.gov (United States)

    Qiu, Yi Lan; Liu, Ru Shi; Wei, Dong Mei; Tian, Hui Qiao

    2006-02-01

    Potassium antimonite precipitation was used to located calcium in the egg cells (before and after anthesis), zygotes and proembryos of lettuce (Lactuca sativa L.). A few calcium precipitates (ppts) were located in the small vacuoles of cytoplasm of egg cell at 3 d before anthesis, when egg cells just formed. Then the small vacuoles fused to form some bigger vacuoles in egg cell at 2d before anthesis. Calcium ppts increased evidently in the cytoplasm and nucleus of egg cells at this time. At 1d before anthesis, a biggest vacuole located at the micropyle end of the cell and its nucleus was pushed toward the chalazal end of the cell, which made an evident cellular polarity. The number of calcium ppts in the egg cell markedly decreased, suggesting that change of calcium distribution may be related to the development of egg cell. After anthesis and before fertilization, calcium ppts were still few in the egg cells, and most of them were accumulated in the nucleus, especially in the vacuoles of nucleolus. At 4h after anthesis, egg cell was fertilized and the wall at the chalazal end of egg cell was formed completely. Calcium ppts evidently increased again in egg cell, and some big ppts appeared in the karyoplasm of nucleus and abundant small ppts in the large vacuole. At 9h after anthesis, zygote completed its first division. Calcium ppts in the nucleus and cytoplasm of two-celled proembryo began to decrease, and only some ones accumulated in the vacuoles of nucleolus. At 18h after anthesis, zygote divided several times and became a multi-celled proembryo. Calcium ppts in the cells of proembryo ulteriorly diminished but there were many ppts on the surface of proembryo. The result indicates that calcium in egg cell, zygote and the cells of proembryo orderly changes its temporal and spatial position, which suggests that calcium may play a role during the development of egg cell and zygote.

  7. Interstitial cells of Cajal, macrophages and mast cells in the gut musculature: morphology, distribution, spatial and possible functional interactions

    DEFF Research Database (Denmark)

    Mikkelsen, Hanne B

    2010-01-01

    Interstitial cells of Cajal (ICC) are recognized as pacemaker cells for gastrointestinal movement and are suggested to be mediators of neuromuscular transmission. Intestinal motility disturbances are often associated with a reduced number of ICC and/or ultrastructural damage, sometimes associated...... with immune cells. Macrophages and mast cells in the intestinal muscularis externa of rodents can be found in close spatial contact with ICC. Macrophages are a constant and regularly distributed cell population in the serosa and at the level of Auerbach's plexus (AP). In human colon, ICC are in close contact...... with macrophages at the level of AP, suggesting functional interaction. It has therefore been proposed that ICC and macrophages interact. Macrophages and mast cells are considered to play important roles in the innate immune defence by producing pro-inflammatory mediators during classical activation, which may...

  8. Distribution of Chromosome Breakpoints in Human Epithelial Cells Exposed to Low- and High-LET Radiation

    Science.gov (United States)

    Hada, Megumi; Zhang, Ye; Cucinotta, Francis A.; Feiveson, Alan; Wu, Honglu

    2010-01-01

    Low-and high-LET radiations produced distinct breakpoint distributions. The difference of the breakpoint distributions between low-and high-LET only appeared in break ends involved in interchromosome exchanges. The breakpoint distributions for break ends participating in intrachromosome exchanges were similar. Gene-rich regions do not necessarily have more chromosome breaks. High-LET appeared to produce long live (data not shown) or longer live breaks that can migrate a longer distance before rejoining with other breaks. Domains occupied by different segments of the chromosomes may be responsible for the breakpoint distribution. The dose responses for interchromosomal exchanges were linear in all four exposures. However, the dose response for intrachromosomal exchanges were none linear. Increasing dose of high dose rate exposure (Fe-ions or -rays) increase the fraction of cells with intrachromosome aberrations, whereas increasing dose of low dose rate exposure (neutrons or -rays) does not affect the fraction of cells with intrachromosome aberrations.

  9. Ontogeny and distribution of cells in B lineage in the American leopard frog, Rana pipiens.

    Science.gov (United States)

    Zettergren, L D

    1982-01-01

    Two-color immunofluorescence techniques were used in order to trace the development and distribution of cells expressing immunoglobulin in Rana pipiens. Evidence is provided which suggests that (i) embryo-larval urogenital tissues are sites of generation of cells in B lineage, (ii) during ontogeny, there is a sequential expression of immunoglobulin isotypes on B cell surfaces, (iii) larvae are able to produce the full range of immunoglobulin clases found in adults, and (iv) at least two subpopulations of lymphocytes exist in Rana pipiens, sIg+ and sIg-; thymocytes and presumably peripheral T cells lack conventional surface immunoglobulin. Some ontogenetic and phylogenetic implications are discussed.

  10. Measurement and estimation of species distribution in a direct methanol fuel cell

    Energy Technology Data Exchange (ETDEWEB)

    Celik, Selahattin; Mat, Mahmut D. [Nigde University, Mechanical Engineering Department, 51100 Nigde (Turkey)

    2010-03-15

    Determination of methanol concentration in a direct methanol fuel cell is crucial for design improvement and performance enhancement. Methanol and water concentrations in a direct methanol fuel cell are experimentally and numerically investigated. In the experimental program, a single cell direct methanol fuel cell is developed and an experimental setup is devised to measure methanol and water concentrations and performance of the cell depending on operating conditions. In theoretical program a mathematical model which includes fluid flow, species distribution, electric field and electrochemistry is adapted and numerically solved. The results showed that the performance of a Direct Methanol Fuel Cell (DMFC) is mainly influenced by operating temperature. A large drop in methanol concentration methanol is measured at the inlet section of cell. The mathematical model is found to satisfactorily capture main physics involved in a DMFC. (author)

  11. Optimal Cell Towers Distribution by using Spatial Mining and Geographic Information System

    CERN Document Server

    AL-Hamami, Alaa H

    2011-01-01

    The appearance of wireless communication is dramatically changing our life. Mobile telecommunications emerged as a technological marvel allowing for access to personal and other services, devices, computation and communication, in any place and at any time through effortless plug and play. Setting up wireless mobile networks often requires: Frequency Assignment, Communication Protocol selection, Routing schemes selection, and cells towers distributions. This research aims to optimize the cells towers distribution by using spatial mining with Geographic Information System (GIS) as a tool. The distribution optimization could be done by applying the Digital Elevation Model (DEM) on the image of the area which must be covered with two levels of hierarchy. The research will apply the spatial association rules technique on the second level to select the best square in the cell for placing the antenna. From that the proposal will try to minimize the number of installed towers, makes tower's location feasible, and pr...

  12. Comparison of temperature distributions inside a PEM fuel cell with parallel and interdigitated gas distributors

    Science.gov (United States)

    Hwang, J. J.; Liu, S. J.

    A comparison of the temperature distributions in a proton exchange membrane (PEM) fuel cell between the parallel-flow gas distributors and the interdigitated gas distributor has been discussed in detail. An electrochemical-thermal coupled numerical model in a five-layer membrane-electrode assembly (MEA) is developed. The temperatures for the reactant fuels as well as the carbon fibers in the porous electrode are predicted by using a CFD technique. The overpotential across the MEA is varied to examine its effect on the temperature distributions of the PEM fuel cell. It is found that both the fuel temperature and the carbon fiber temperature are increased with increasing the total overpotential. In addition, the fuel and carbon-fiber temperature distributions are significantly affected by the flow pattern that cast on the gas distributor. Replacing the parallel-flow gas distributor by the interdigitated gas distributor will increase the local maximum temperature inside the PEM fuel cell.

  13. Modeling and analysis of the HPM pulse-width upset effect on CMOS inverter

    Science.gov (United States)

    Xinhai, Yu; Changchun, Chai; Liping, Qiao; Yintang, Yang; Yang, Liu; Xiaowen, Xi

    2015-05-01

    We derive analytical models of the excess carrier density distribution and the HPM (high-power microwave) upset susceptibility with dependence of pulse-width, which are validated by the simulated results and experimental data. Mechanism analysis and model derivation verify that the excess carriers dominate the current amplification process of the latch-up. Our results reveal that the excess carrier density distribution in P-substrate behaves as pulse-width dependence. The HPM upset voltage threshold Vp decreases with the incremental pulse-width, while there is an inflection point which is caused because the excess carrier accumulation in the P-substrate will be suppressed over time. For the first time, the physical essence of the HPM pulse-width upset effect is proposed to be the excess carrier accumulation effect. Validation concludes that the Vp model is capable of giving a reliable and accurate prediction to the HPM upset susceptibility of a CMOS inverter, which simultaneously considers technology information, ambient temperature, and layout parameters. From the model, the layout parameter LB has been demonstrated to have a significant impact on the pulse-width upset effect: a CMOS inverter with minor LB is more susceptible to HPM, which enables us to put forward hardening measures for inverters that are immune from the HPM upset. Project supported by the National Natural Science Foundation of China (No. 60776034) and the State Key Development Program for Basic Research of China (No. 2014CB339900).

  14. Arginine starvation in colorectal carcinoma cells: Sensing, impact on translation control and cell cycle distribution.

    Science.gov (United States)

    Vynnytska-Myronovska, Bozhena O; Kurlishchuk, Yuliya; Chen, Oleh; Bobak, Yaroslav; Dittfeld, Claudia; Hüther, Melanie; Kunz-Schughart, Leoni A; Stasyk, Oleh V

    2016-02-01

    Tumor cells rely on a continued exogenous nutrient supply in order to maintain a high proliferative activity. Although a strong dependence of some tumor types on exogenous arginine sources has been reported, the mechanisms of arginine sensing by tumor cells and the impact of changes in arginine availability on translation and cell cycle regulation are not fully understood. The results presented herein state that human colorectal carcinoma cells rapidly exhaust the internal arginine sources in the absence of exogenous arginine and repress global translation by activation of the GCN2-mediated pathway and inhibition of mTOR signaling. Tumor suppressor protein p53 activation and G1/G0 cell cycle arrest support cell survival upon prolonged arginine starvation. Cells with the mutant or deleted TP53 fail to stop cell cycle progression at defined cell cycle checkpoints which appears to be associated with reduced recovery after durable metabolic stress triggered by arginine withdrawal.

  15. Distribution of microglial cells in the cerebral hemispheres of embryonic and neonatal chicks

    Directory of Open Access Journals (Sweden)

    A.R. Ignácio

    2005-11-01

    Full Text Available The distribution, morphology and morphometry of microglial cells in the chick cerebral hemispheres from embryonic day 4 (E4 to the first neonatal day (P1 were studied by histochemical labeling with a tomato (Lycopersicon esculentum lectin. The histochemical analysis revealed lectin-reactive cells in the nervous parenchyma on day E4. Between E4 (5.7 ± 1.35 mm length and E17 (8.25 ± 1.2 mm length, the lectin-reactive cells were identified as ameboid microglia and observed starting from the subventricular layer, distributed throughout the mantle layer and in the proximity of the blood vessels. After day E13, the lectin-reactive cells exhibited elongated forms with small branched processes, and were considered primitive ramified microglia. Later, between E18 (5.85 ± 1.5 mm cell body length and P1 (3.25 ± 0.6 mm cell body length, cells with more elongated branched processes were observed, constituting the ramified microglia. Our findings provide additional information on the migration and differentiation of microglial cells, whose ramified form is observed at the end of embryonic development. The present paper focused on the arrangement of microglial cells in developing cerebral hemispheres of embryonic and neonatal chicks, which are little studied in the literature. Details of morphology, morphometry and spatial distribution of microglial cells contributed to the understanding of bird and mammal central nervous system ontogeny. Furthermore, the identification and localization of microglial cells during the normal development could be used as a morphological guide for embryonic brain injury researches.

  16. STELLAR LOCI. I. METALLICITY DEPENDENCE AND INTRINSIC WIDTHS

    Energy Technology Data Exchange (ETDEWEB)

    Yuan, Haibo; Liu, Xiaowei [Kavli Institute for Astronomy and Astrophysics, Peking University, Beijing 100871 (China); Xiang, Maosheng; Huang, Yang; Chen, Bingqiu, E-mail: yuanhb4861@pku.edu.cn, E-mail: x.liu@pku.edu.cn [Department of Astronomy, Peking University, Beijing 100871 (China)

    2015-02-01

    Stellar loci are widely used for selection of interesting outliers, reddening determinations, and calibrations. However, until now, the dependence of stellar loci on metallicity has not been fully explored, and their intrinsic widths are unclear. In this paper, by combining the spectroscopic and recalibrated imaging data of the Sloan Digital Sky Survey (SDSS) Stripe 82, we have built a large, clean sample of dwarf stars with accurate colors and well-determined metallicities to investigate the metallicity dependence and intrinsic widths of the SDSS stellar loci. Typically, 1 dex decrease in metallicity causes 0.20 and 0.02 mag decrease in colors u – g and g – r and 0.02 and 0.02 mag increase in colors r – i and i – z, respectively. The variations are larger for metal-rich stars than for metal-poor ones, and larger for F/G/K stars than for A/M ones. Using the sample, we have performed two-dimensional polynomial fitting to the u – g, g – r, r – i, and i – z colors as a function of color g – i and metallicity [Fe/H]. The residuals, at the level of 0.029, 0.008, 0.008, and 0.011 mag for the u – g, g – r, r – i, and i – z colors, respectively, can be fully accounted for by the photometric errors and metallicity uncertainties, suggesting that the intrinsic widths of the loci are at maximum a few millimagnitudes. The residual distributions are asymmetric, revealing that a significant fraction of stars are binaries. In a companion paper, we will present an unbiased estimate of the binary fraction for field stars. Other potential applications of the metallicity-dependent stellar loci are briefly discussed.

  17. Exact, time-independent estimation of clone size distributions in normal and mutated cells.

    Science.gov (United States)

    Roshan, A; Jones, P H; Greenman, C D

    2014-10-06

    Biological tools such as genetic lineage tracing, three-dimensional confocal microscopy and next-generation DNA sequencing are providing new ways to quantify the distribution of clones of normal and mutated cells. Understanding population-wide clone size distributions in vivo is complicated by multiple cell types within observed tissues, and overlapping birth and death processes. This has led to the increased need for mathematically informed models to understand their biological significance. Standard approaches usually require knowledge of clonal age. We show that modelling on clone size independent of time is an alternative method that offers certain analytical advantages; it can help parametrize these models, and obtain distributions for counts of mutated or proliferating cells, for example. When applied to a general birth-death process common in epithelial progenitors, this takes the form of a gambler's ruin problem, the solution of which relates to counting Motzkin lattice paths. Applying this approach to mutational processes, alternative, exact, formulations of classic Luria-Delbrück-type problems emerge. This approach can be extended beyond neutral models of mutant clonal evolution. Applications of these approaches are twofold. First, we resolve the probability of progenitor cells generating proliferating or differentiating progeny in clonal lineage tracing experiments in vivo or cell culture assays where clone age is not known. Second, we model mutation frequency distributions that deep sequencing of subclonal samples produce.

  18. Simulation and in situ measurement of stress distribution in a polymer electrolyte membrane fuel cell stack

    Science.gov (United States)

    de la Cruz, Javier; Cano, Ulises; Romero, Tatiana

    2016-10-01

    A critical parameter for PEM fuel cell's electric contact is the nominal clamping pressure. Predicting the mechanical behavior of all components in a fuel cell stack is a very complex task due to the diversity of materials properties. Prior to the integration of a 3 kW PEMFC power plant, a numerical simulation was performed in order to obtain the mechanical stress distribution for two of the most pressure sensitive components of the stack: the membrane, and the graphite plates. The stress distribution of the above mentioned components was numerically simulated by finite element analysis and the stress magnitude for the membrane was confirmed using pressure films. Stress values were found within the elastic zone which guarantees mechanical integrity of fuel cell components. These low stress levels particularly for the membrane will allow prolonging the life and integrity of the fuel cell stack according to its design specifications.

  19. Endocytosis regulates cell soma translocation and the distribution of adhesion proteins in migrating neurons.

    Directory of Open Access Journals (Sweden)

    Jennifer C Shieh

    Full Text Available Newborn neurons migrate from their birthplace to their final location to form a properly functioning nervous system. During these movements, young neurons must attach and subsequently detach from their substrate to facilitate migration, but little is known about the mechanisms cells use to release their attachments. We show that the machinery for clathrin-mediated endocytosis is positioned to regulate the distribution of adhesion proteins in a subcellular region just proximal to the neuronal cell body. Inhibiting clathrin or dynamin function impedes the movement of migrating neurons both in vitro and in vivo. Inhibiting dynamin function in vitro shifts the distribution of adhesion proteins to the rear of the cell. These results suggest that endocytosis may play a critical role in regulating substrate detachment to enable cell body translocation in migrating neurons.

  20. Particle-in-cell simulation for different magnetic mirror effects on the plasma distribution in a cusped field thruster

    Science.gov (United States)

    Liu, Hui; Chen, Peng-Bo; Zhao, Yin-Jian; Yu, Da-Ren

    2015-08-01

    Magnetic mirror used as an efficient tool to confine plasma has been widely adopted in many different areas especially in recent cusped field thrusters. In order to check the influence of magnetic mirror effect on the plasma distribution in a cusped field thruster, three different radii of the discharge channel (6 mm, 4 mm, and 2 mm) in a cusped field thruster are investigated by using Particle-in-Cell Plus Monte Carlo (PIC-MCC) simulated method, under the condition of a fixed axial length of the discharge channel and the same operating parameters. It is found that magnetic cusps inside the small radius discharge channel cannot confine electrons very well. Thus, the electric field is hard to establish. With the reduction of the discharge channel’s diameter, more electrons will escape from cusps to the centerline area near the anode due to a lower magnetic mirror ratio. Meanwhile, the leak width of the cusped magnetic field will increase at the cusp. By increasing the magnetic field strength in a small radius model of a cusped field thruster, the negative effect caused by the weak magnetic mirror effect can be partially compensated. Therefore, according to engineering design, the increase of magnetic field strength can contribute to obtaining a good performance, when the radial distance between the magnets and the inner surface of the discharge channel is relatively big. Project supported by the National Natural Science Foundation of China (Grant No. 51006028) and the Foundation for Innovative Research Groups of the National Natural Science Foundation of China (Grant No. 51121004).

  1. Using a GFP-gene fusion technique to study the cell cycle-dependent distribution of calmodulin in living cells

    Institute of Scientific and Technical Information of China (English)

    李朝军; 吕品; 张东才

    1999-01-01

    In this study, a green fluorescent protein (GFP)-calmodulin (CaM) fusion gene method was used to examine the distribution of calmodulin during various stages of cell cycle. First, it was found that the distribution of CaM in living cells changes with the cell cycle. CaM was found mainly in the cytoplasm during G1 phase. It began to move into the nucleus when the cell entered S phase. At G2 phase, CaM became more concentrated in the nucleus than in cytoplasm. Second, the accumulation of CaM in the nucleus during G2 phase appeared to be related to the onset of mitosis, since inhibiting the activation of CaM at this stage resulted in blocking the nuclear membrane breakdown and chromatin condensation. Finally, after the cell entered mitosis, a high concentration of CaM was found at the polar regions of the mitotic spindle. At this time, inhibiting the activity of CaM would cause a disruption of the spindle structure. The relationship between the stage-specific distribution of CaM and its function in regulat

  2. Thermal Design and Performance of the Electrical Distribution Feed Box of the LHC prototype cell

    CERN Document Server

    Calzas-Rodriguez, C; Hauviller, Claude; Poncet, Alain; Sacré, P; Serio, L

    2002-01-01

    The Electrical Distribution Feed Box (DFBS) is a 4.5 K saturated liquid helium cryostat constructed for the Large Hadron Collider (LHC) Prototype Cell (String 2). The thermal design of the DFBS is presented, with emphasis on the modelling of the cooling of the current lead chimneys via the helium bath boil-off gas and on the design of the lambda plate. The expected performance is compared to measurements done during the first operation phase of the LHC prototype cell.

  3. Observation of DNA and protein distributions in mammalian cell nuclei using STXM

    Science.gov (United States)

    Ohigashi, Takuji; Ito, Atsushi; Shinohara, Kunio; Tone, Shigenobu; Kado, Masataka; Inagaki, Yuichi; Wang, Yu-Fu; Kosugi, Nobuhiro

    2016-01-01

    A whole A549 cell and isolated nuclei of HeLa S3 cells in the apoptotic process were investigated by using a scanning transmission X-ray microscope (STXM) in the UVSOR Synchrotron (Okazaki, Japan). Near edge X-ray absorption fine structures (NEXAFS) of DNA and histone in the N K-edge region were measured as reference and their distribution in the nuclei was determined by using these reference spectra. The four stages of the apoptosis were successfully distinguished.

  4. Spatial distribution of excitatory synapses on the dendrites of ganglion cells in the mouse retina.

    Science.gov (United States)

    Chen, Yin-Peng; Chiao, Chuan-Chin

    2014-01-01

    Excitatory glutamatergic inputs from bipolar cells affect the physiological properties of ganglion cells in the mammalian retina. The spatial distribution of these excitatory synapses on the dendrites of retinal ganglion cells thus may shape their distinct functions. To visualize the spatial pattern of excitatory glutamatergic input into the ganglion cells in the mouse retina, particle-mediated gene transfer of plasmids expressing postsynaptic density 95-green fluorescent fusion protein (PSD95-GFP) was used to label the excitatory synapses. Despite wide variation in the size and morphology of the retinal ganglion cells, the expression of PSD95 puncta was found to follow two general rules. Firstly, the PSD95 puncta are regularly spaced, at 1-2 µm intervals, along the dendrites, whereby the presence of an excitatory synapse creates an exclusion zone that rules out the presence of other glutamatergic synaptic inputs. Secondly, the spatial distribution of PSD95 puncta on the dendrites of diverse retinal ganglion cells are similar in that the number of excitatory synapses appears to be less on primary dendrites and to increase to a plateau on higher branch order dendrites. These observations suggest that synaptogenesis is spatially regulated along the dendritic segments and that the number of synaptic contacts is relatively constant beyond the primary dendrites. Interestingly, we also found that the linear puncta density is slightly higher in large cells than in small cells. This may suggest that retinal ganglion cells with a large dendritic field tend to show an increased connectivity of excitatory synapses that makes up for their reduced dendrite density. Mapping the spatial distribution pattern of the excitatory synapses on retinal ganglion cells thus provides explicit structural information that is essential for our understanding of how excitatory glutamatergic inputs shape neuronal responses.

  5. Nonlinear Recurrent Neural Network Predictive Control for Energy Distribution of a Fuel Cell Powered Robot

    Directory of Open Access Journals (Sweden)

    Qihong Chen

    2014-01-01

    Full Text Available This paper presents a neural network predictive control strategy to optimize power distribution for a fuel cell/ultracapacitor hybrid power system of a robot. We model the nonlinear power system by employing time variant auto-regressive moving average with exogenous (ARMAX, and using recurrent neural network to represent the complicated coefficients of the ARMAX model. Because the dynamic of the system is viewed as operating- state- dependent time varying local linear behavior in this frame, a linear constrained model predictive control algorithm is developed to optimize the power splitting between the fuel cell and ultracapacitor. The proposed algorithm significantly simplifies implementation of the controller and can handle multiple constraints, such as limiting substantial fluctuation of fuel cell current. Experiment and simulation results demonstrate that the control strategy can optimally split power between the fuel cell and ultracapacitor, limit the change rate of the fuel cell current, and so as to extend the lifetime of the fuel cell.

  6. Nonlinear recurrent neural network predictive control for energy distribution of a fuel cell powered robot.

    Science.gov (United States)

    Chen, Qihong; Long, Rong; Quan, Shuhai; Zhang, Liyan

    2014-01-01

    This paper presents a neural network predictive control strategy to optimize power distribution for a fuel cell/ultracapacitor hybrid power system of a robot. We model the nonlinear power system by employing time variant auto-regressive moving average with exogenous (ARMAX), and using recurrent neural network to represent the complicated coefficients of the ARMAX model. Because the dynamic of the system is viewed as operating- state- dependent time varying local linear behavior in this frame, a linear constrained model predictive control algorithm is developed to optimize the power splitting between the fuel cell and ultracapacitor. The proposed algorithm significantly simplifies implementation of the controller and can handle multiple constraints, such as limiting substantial fluctuation of fuel cell current. Experiment and simulation results demonstrate that the control strategy can optimally split power between the fuel cell and ultracapacitor, limit the change rate of the fuel cell current, and so as to extend the lifetime of the fuel cell.

  7. Distribution of parvalbumin-immunoreactive cells and fibers in the monkey temporal lobe: the hippocampal formation.

    Science.gov (United States)

    Pitkänen, A; Amaral, D G

    1993-05-01

    The distribution of parvalbumin-immunoreactive cells and fibers in the various fields of the hippocampal formation was studied in the macaque monkey. Parvalbumin-immunoreactive neurons had aspiny or sparsely spiny dendrites that often had a beaded appearance; most resembled classically identified interneurons. Parvalbumin-immunoreactive fibers and terminals were confined to certain laminae in each field and generally had a pericellular distribution. In the dentate gyrus, there was a dense pericellular plexus of immunoreactive terminals in the granule cell layer. Except for a narrow supragranular zone, there was a marked paucity of terminals in the molecular and polymorphic cell layers. Immunoreactive neurons were mainly located immediately subjacent to the granule cell layer and comprised a variety of morphological cell types. The three fields of the hippocampus proper (CA3, CA2, and CA1) demonstrated differences in their parvalbumin staining characteristics. In CA3, there was a prominent pericellular terminal plexus in the pyramidal cell layer that was densest distally (closer to CA2). Immunoreactive cells were located either in the pyramidal cell layer, where many had a pyramidal shape and prominent apical and basal dendrites, or in stratum oriens. CA2 had a staining pattern similar to that in CA3, though both the number of labeled cells and the density of the pericellular terminal plexus were greater in CA2. In CA1, there was a markedly lower number of parvalbumin-labeled cells than in CA3 and CA2 and the cells tended to be located in the deep part of the pyramidal cell layer or in stratum oriens. The pyramidal cell layer of CA1 contained a pericellular terminal plexus that was substantially less dense than in CA3 and CA2. At the border between CA1 and the subiculum there was a marked increase in the number of parvalbumin-immunoreactive neurons. The positive cells were scattered throughout the pyramidal cell layer of the subiculum and comprised a variety of

  8. Dynamic distribution and stem cell characteristics of Sox1-expressing cells in the cerebellar cortex

    Institute of Scientific and Technical Information of China (English)

    Joelle Alcock; Virginie Sottile

    2009-01-01

    Bergmann glia cells are a discrete radial glia population surrounding Purkinje cells in the cerebellar cortex. Al-though Bergmann glia are essential for the development and correct arborization of Purkinje cells, little is known about the regulation of this cell population after the developmental phase. In an effort to characterize this population at the molecular level, we have analyzed marker expression and established that adult Bergmann glia express Soxl, Sox2 and Sox9, a feature otherwise associated with neural stem cells (NSCs). In the present study, we have further analyzed the developmental pattern of Soxl-expressing cells in the developing cerebellum. We report that before be-coming restricted to the Purkinje cell layer, Soxl-positive cells are present throughout the immature tissue, and that these cells show characteristics of Bergmann glia progenitors. Our study shows that these progenitors express Soxl, Sox2 and Sox9, a signature maintained throughout cerebellar maturation into adulthood. When isolated in culture, the Soxl-expressing cerebellar population exhibited neurosphere-forming ability, NSC-marker characteristics, and demonstrated multipotency at the clonal level. Our results show that the Bergmann glia population expresses Soxl during cerebellar development, and that these cells can be isolated and show stem cell characteristics in vitro, sug-gesting that they could hold a broader potential than previously thought.

  9. Spatial distribution of niche and stem cells in ex vivo human limbal cultures.

    Science.gov (United States)

    Mariappan, Indumathi; Kacham, Santhosh; Purushotham, Jyothi; Maddileti, Savitri; Siamwala, Jamila; Sangwan, Virender Singh

    2014-11-01

    Stem cells at the limbus mediate corneal epithelial regeneration and regulate normal tissue homeostasis. Ex vivo cultured limbal epithelial transplantations are being widely practiced in the treatment of limbal stem cell deficiency. In this report, we examined whether the limbal niche cells that nurture and regulate epithelial stem cells coexist in ex vivo limbal cultures. We also compared the inherent differences between explant and suspension culture systems in terms of spatial distribution of niche cells and their effect on epithelial stem cell proliferation, migration, and differentiation in vitro. We report that the stem cell content of both culture systems was similar, explaining the comparable clinical outcomes reported using these two methods. We also showed that the niche cells get expanded in culture and the nestin-positive cells migrate at the leading edges to direct epithelial cell migration in suspension cultures, whereas they are limited to the intact niche in explant cultures. We provide evidence that C/EBPδ-positive, p15-positive, and quiescent, label-retaining, early activated stem cells migrate at the leading edges to regulate epithelial cell proliferation in explant cultures, and this position effect is lost in early suspension cultures. However, in confluent suspension cultures, the stem cells and niche cells interact with each another, migrate in spiraling patterns, and self-organize to form three-dimensional niche-like compartments resembling the limbal crypts and thereby reestablish the position effect. These 3D-sphere clusters are enriched with nestin-, vimentin-, S100-, and p27-positive niche cells and p15-, p21-, p63α-, C/EBPδ-, ABCG2-, and Pax6-positive quiescent epithelial stem cells.

  10. Size distribution of retrovirally marked lineages matches prediction from population measurements of cell cycle behavior

    Science.gov (United States)

    Cai, Li; Hayes, Nancy L.; Takahashi, Takao; Caviness, Verne S Jr; Nowakowski, Richard S.

    2002-01-01

    Mechanisms that regulate neuron production in the developing mouse neocortex were examined by using a retroviral lineage marking method to determine the sizes of the lineages remaining in the proliferating population of the ventricular zone during the period of neuron production. The distribution of clade sizes obtained experimentally in four different injection-survival paradigms (E11-E13, E11-E14, E11-E15, and E12-E15) from a total of over 500 labeled lineages was compared with that obtained from three models in which the average behavior of the proliferating population [i.e., the proportion of cells remaining in the proliferative population (P) vs. that exiting the proliferative population (Q)] was quantitatively related to lineage size distribution. In model 1, different proportions of asymmetric, symmetric terminal, and symmetric nonterminal cell divisions coexisted during the entire developmental period. In model 2, the developmental period was divided into two epochs: During the first, asymmetric and symmetric nonterminal cell divisions occurred, but, during the second, asymmetric and symmetric terminal cell divisions occurred. In model 3, the shifts in P and Q are accounted for by changes in the proportions of the two types of symmetric cell divisions without the inclusion of any asymmetric cell divisions. The results obtained from the retroviral experiments were well accounted for by model 1 but not by model 2 or 3. These findings demonstrate that: 1) asymmetric and both types of symmetric cell divisions coexist during the entire period of neurogenesis in the mouse, 2) neuron production is regulated in the proliferative population by the independent decisions of the two daughter cells to reenter S phase, and 3) neurons are produced by both asymmetric and symmetric terminal cell divisions. In addition, the findings mean that cell death and/or tangential movements of cells in the proliferative population occur at only a low rate and that there are no

  11. Ganglion cell distribution and retinal resolution in the Florida manatee, Trichechus manatus latirostris.

    Science.gov (United States)

    Mass, Alla M; Ketten, Darlene R; Odell, Daniel K; Supin, Alexander Ya

    2012-01-01

    The topographic organization of retinal ganglion cells was examined in the Florida manatee (Trichechus manatus latirostris) to assess ganglion cell size and distribution and to estimate retinal resolution. The ganglion cell layer of the manatee's retina was comprised primarily of large neurons with broad intercellular spaces. Cell sizes varied from 10 to 60 μm in diameter (mean 24.3 μm). The retinal wholemounts from adult animals measured 446-501 mm(2) in area with total ganglion cell counts of 62,000-81,800 (mean 70,200). The cell density changed across the retina, with the maximum in the area below the optic disc and decreasing toward the retinal edges and in the immediate vicinity of the optic disc. The maximum cell density ranged from 235 to 337 cells per millimeter square in the adult retinae. Two wholemounts obtained from juvenile animals were 271 and 282 mm(2) in area with total cell numbers of 70,900 and 68,700, respectively (mean 69,800), that is, nearly equivalent to those of adults, but juvenile retinae consequently had maximum cell densities that were higher than those of adults: 478 and 491 cells per millimeter square. Calculations indicate a retinal resolution of ∼19' (1.6 cycles per degree) in both adult and juvenile retinae.

  12. Visual-Width of an Ultrasonic Gaussian Beam on the Schlieren Photograph and Explanation to the Nonspecularly Reflected Sound Field

    Institute of Scientific and Technical Information of China (English)

    ZHU Guo-Zhen; SUN Yao; FU De-Yong

    2004-01-01

    @@ On the Schlieren photograph, a continuous ultrasonic Gaussian beam and its nonspecularly reflected beams [Chin.Phys. Lett. 16 (1999) 819] always have limited visual-width, although the theoretical spatial distribution of the sound field is a continuous function. To study this problem, the first step is to investigate the visual-width of the beam on the photograph related to the sound pressure at the centre of the beam by the threshold of the optical system caused by the refraction of light; the second step is to explain the visual-width of nonspecularly reflected field. By applying a relevant threshold, checked by the visual width of the incident beam, to cut the theoretical curves of the reflected sound field, one can find the visual-width of the two reflected beams and the gap between them correspond to that on the Schlieren photograph.

  13. The significance of biometric parameters in determining anterior teeth width

    Directory of Open Access Journals (Sweden)

    Strajnić Ljiljana

    2013-01-01

    Full Text Available Background/Aim. An important element of prosthetic treatment of edentulous patients is selecting the size of anterior artificial teeth that will restore the natural harmony of one’s dentolabial structure as well as the whole face. The main objective of this study was to determine the correlation between the inner canthal distance (ICD and interalar width (IAW on one side and the width of both central incisors (CIW, the width of central and lateral incisors (CLIW, the width of anterior teeth (ATW, the width between the canine cusps (CCW, which may be useful in clinical practice. Methods. A total of 89 subjects comprising 23 male and 66 female were studied. Their age ranged from 19 to 34 years with the mean of 25 years. Only the subjects with the preserved natural dentition were included in the sample. All facial and intraoral tooth measurements were made with a Boley Gauge (Buffalo Dental Manufacturing Co., Brooklyn NY, USA having a resolution of 0.1mm. Results. A moderate correlation was established between the interalar width and combined width of anterior teeth and canine cusp width (r = 0.439, r = 0.374. A low correlation was established between the inner canthal distance and the width of anterior teeth and canine cusp width (r = 0.335, r = 0.303. The differences between the two genders were highly significant for all the parameters (p < 0.01. The measured facial distances and width of anterior teeth were higher in men than in women. Conclusion. The results of this study suggest that the examined interalar width and inner canthal distance cannot be considered reliable guidelines in the selection of artificial upper anterior teeth. However, they may be used as a useful additional factor combined with other methods for objective tooth selection. The final decision should be made while working on dentures fitting models with the patient’s consent.

  14. Half-width at half-maximum, full-width at half-maximum analysis for resolution of asymmetrically apodized optical systems with slit apertures

    Indian Academy of Sciences (India)

    Andra Naresh Kumar Reddy; Dasari Karuna Sagar

    2015-01-01

    Resolution for the modified point spread function (PSF) of asymmetrically apodized optical systems has been analysed by a new parameter half-width at half-maximum (HWHM) in addition to the well-defined parameter full-width at half-maximum (FWHM). The distribution of half-maximum energy in the centroid of modified PSF has been investigated in terms of HWHM on good side and HWHM on bad side. We observed that as the asymmetry in PSF increases, FWHM of the main peak increases and then decreases and is being aided by the degree of amplitude apodization in the central region of slit functions. In the present study, HWHM (half-width at half-maximum) of the resultant PSF has been defined to characterize the resolution of the detection system. It is essentially a line of projection, which measures the width of the main lobe at its half-maximum position from the diffraction centre and has been computed for various amplitudes and antiphase apodizations of the slit aperture. We have noticed that HWHM on the good side decreases at the cost of the increased HWHM on the bad side in the presence of asymmetric apodization.

  15. Control strategy of hybrid fuel cell/battery distributed generation system for grid-connected operation

    Institute of Scientific and Technical Information of China (English)

    Masoud Aliakbar GOLKAR; Amin HAJIZADEH

    2009-01-01

    This paper presents a control strategy of a hybrid fuel cell/battery distributed generation (HDG) system in distribution systems. The overall structure of the HDG system is given, dynamic models for the solid oxide fuel cell (SOFC) power plant,battery bank and its power electronic interfacing are briefly described, and controller design methodologies for the power conditioning units and fuel cell to control the power flow from the hybrid power plant to the utility grid are presented. To distribute the power between the fuel cell power plant and the battery energy storage, a neuro-fuzzy controller has been developed. Also, for controlling the active and reactive power independently in distribution systems, the current control strategy based on two fuzzy logic controllers has been presented. A Matlab/Simulink simulation model is developed for the HDG system by combining the individual component models and their controllers. Simulation results show the overall system performance including load-following and power management of the HDG system.

  16. Sizing stack and battery of a fuel cell hybrid distribution truck

    NARCIS (Netherlands)

    Tazelaar, Edwin; Shen, Y.; Veenhuizen, Bram; Hofman, T.; Bosch, P. van den

    2012-01-01

    An existing fuel cell hybrid distribution truck, built for demonstration purposes, is used as a case study to investigate the effect of stack (kW) and battery (kW, kWh) sizes on the hydrogen consumption of the vehicle. Three driving cycles, the NEDC for Low Power vehicles, CSC and JE05 cycle, define

  17. Measuring the complete cross-cell carrier mobility distributions in bulk heterojunction solar cells

    Science.gov (United States)

    Seifter, Jason; Sun, Yanming; Choi, Hyosung; Lee, Byoung Hoon; Heeger, Alan

    2015-03-01

    Carbon nanotube-enabled, vertical, organic field effect transistors (CN-VFETs) based on the small molecule dinaphtho[2,3-b:2',3'-f]thieno[3,2-b]thiophene (DNTT) have demonstrated high current, low-power operation suitable for driving active matix organic light emitting diode (AMOLED) displays. This performance is achieved without the need for costly high-resolution patterning, despite the low mobility of the organic semiconductor, by employing sub-micron channel widths, defined in the vertical devices by the thickness of the semiconducting layer. Replacing the thermally evaporated small molecule semiconductor with a solution-processed polymer would possibly further simplify the fabrication process and reduce manufacturing cost. Here we investigate several polymer systems as wide bandgap semiconducting channel layers for potentially air stable and transparent CN-VFETs. The field effect mobility and optical transparency of the polymer layers are determined, and the performance and air stability of CN-VFET devices are measured. A. S. gratefully acknowledges support from the National Science Foundation under DMR-1156737.

  18. Global dynamics of cell mediated immunity in viral infection models with distributed delays

    CERN Document Server

    Nakata, Yukihiko

    2010-01-01

    In this paper, we investigate global dynamics for a system of delay differential equations which describes a virus-immune interaction in \\textit{vivo}. The model has two distributed time delays describing time needed for infection of cell and virus replication. Our model admits three possible equilibria, an uninfected equilibrium and infected equilibrium with or without immune response depending on the basic reproduction number for viral infection $R_{0}$ and for CTL response $R_{1}$ such that $R_{1}1$. The immune activation has a positive role in the reduction of the infection cells and the increasing of the uninfected cells if $R_{1}>1$.

  19. Rac1+ cells distributed in accordance with CD 133+ cells in glioblastomas and the elevated invasiveness of CD 133+ glioma cells with higher Rac1 activity

    Institute of Scientific and Technical Information of China (English)

    ZHANG Bin; SUN Jian; YU Sheng-ping; CHEN Cong; LIU Bin; LIU Zhi-feng; REN Bing-cheng; MING Hao-lang; YANG Xue-jun

    2012-01-01

    Background Recent studies have suggested that cancer stem cells are one of the major causes for tumor recurrence due to their resistance to radiotherapy and chemotherapy.Although the highly invasive nature of glioblastoma (GBM)cells is also implicated in the failure of current therapies,it is not clear how glioma stem cells (GSCs) are involved in invasiveness.Rac1 activity is necessary for inducing reorganization of actin cytoskeleton and cell movement.In this study,we aimed to investigate the distribution characteristics of CD133+ cells and Rac1+ cells in GBM as well as Rac1 activity in CD133+ GBM cells,and analyze the migration and invasion potential of these cells.Methods A series of 21 patients with GBM were admitted consecutively and received tumor resection in Tianjin Medical University General Hospital during the first half of the year 2011.Tissue specimens were collected both from the peripheral and the central parts for each tumor under magnetic resonance imaging (MRI) navigation guidance.Immunohistochemical staining was used to detect the CD133+ cells and Rac1+ cells distribution in GBM specimens.Double-labeling immunofluorescence was further used to analyze CD133 and Rac1 co-expression and the relationship between CD133+ cells distribution and Rac1 expression.Serum-free medium culture and magnetic sorting were used to isolate CD133+ cells from U87 cell line.Rac1 activation assay was conducted to assess the activation of Rac1 in CD133+ and CD133-U87 cells.The migration and invasive ability of CD133+ and CD133-U87 cells were determined by cell migration and invasion assays in vitro.Student's t-test and one-way analysis of variance (ANOVA) test were used to determine statistical significance in this study.Results In the central parts of GBMs,CD133+ cells were found to cluster around necrosis and occasionally cluster around the vessels under the microscope by immunohistological staining.In the peripheral parts of the tumors,CD133+ cells were lined up along

  20. Elucidating the Uptake and Distribution of Nanoparticles in Solid Tumors via a Multilayered Cell Culture Model

    Institute of Scientific and Technical Information of China (English)

    Darren Yohan; Charmainne Cruje; Xiaofeng Lu; Devika Chithrani

    2015-01-01

    Multicellular layers (MCLs) have previously been used to determine the pharmacokinetics of a variety of different cancer drugs including paclitaxel, doxorubicin, methotrexate, and 5-fluorouracil across a number of cell lines. It is not known how nanoparticles (NPs) navigate through the tumor microenvironment once they leave the tumor blood vessel. In this study, we used the MCL model to study the uptake and penetration dynamics of NPs. Gold nanoparticles (GNPs) were used as a model system to map the NP distribution within tissue-like structures. Our results show that NP uptake and transport are dependent on the tumor cell type. MDA-MB-231 tissue showed deeper penetration of GNPs as compared to MCF-7 one. Intracellular and extracellular distributions of NPs were mapped using CytoViva imaging. The ability of MCLs to mimic tumor tissue characteristics makes them a useful tool in assessing the efficacy of particle distribution in solid tumors.

  1. Biologic width and its importance in periodontal and restorative dentistry

    Directory of Open Access Journals (Sweden)

    Babitha Nugala

    2012-01-01

    Full Text Available An adequate understanding of the relationship between periodontal tissues and restorative dentistry is paramount to ensure adequate form, function, esthetics and comfort of the dentition. While most clinicians are aware of this important relationship, uncertainty remains regarding specific concepts such as biologic width, its maintenance and applications of crown lengthening in cases of biologic width violation. Relevant publications regarding biologic width, its violation and management were identified up to August 2011 using manual and electronic database search in Medline, Embase, Directory of Open Access Journals and Google Scholar. This review discusses the concept of biologic width around tooth and its relationship to periodontal health and restorative dentistry.

  2. A Statistical Approach for Obtaining the Controlled Woven Fabric Width

    Directory of Open Access Journals (Sweden)

    Shaker Khubab

    2015-12-01

    Full Text Available A common problem faced in fabric manufacturing is the production of inconsistent fabric width on shuttleless looms in spite of the same fabric specifications. Weft-wise crimp controls the fabric width and it depends on a number of factors, including warp tension, temple type, fabric take-up pressing tension and loom working width. The aim of this study is to investigate the effect of these parameters on the fabric width produced. Taguchi’s orthogonal design was used to optimise the weaving parameters for obtaining controlled fabric width. On the basis of signal to noise ratios, it could be concluded that controlled fabric width could be produced using medium temple type and intense take-up pressing tension at relatively lower warp tension and smaller loom working width. The analysis of variance revealed that temple needle size was the most significant factor affecting the fabric width, followed by loom working width and warp tension, whereas take-up pressing tension was least significant of all the factors investigated in the study.

  3. Implications of Satellite Swath Width on Global Aerosol Optical Thickness Statistics

    Science.gov (United States)

    Colarco, Peter; Kahn, Ralph; Remer, Lorraine; Levy, Robert; Welton, Ellsworth

    2012-01-01

    We assess the impact of swath width on the statistics of aerosol optical thickness (AOT) retrieved by satellite as inferred from observations made by the Moderate Resolution Imaging Spectroradiometer (MODIS). We sub-sample the year 2009 MODIS data from both the Terra and Aqua spacecraft along several candidate swaths of various widths. We find that due to spatial sampling there is an uncertainty of approximately 0.01 in the global, annual mean AOT. The sub-sampled monthly mean gridded AOT are within +/- 0.01 of the full swath AOT about 20% of the time for the narrow swath sub-samples, about 30% of the time for the moderate width sub-samples, and about 45% of the time for the widest swath considered. These results suggest that future aerosol satellite missions with only a narrow swath view may not sample the true AOT distribution sufficiently to reduce significantly the uncertainty in aerosol direct forcing of climate.

  4. Direct measurement of the total decay width of the top quark.

    Science.gov (United States)

    Aaltonen, T; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Appel, J A; Arisawa, T; Artikov, A; Asaadi, J; Ashmanskas, W; Auerbach, B; Aurisano, A; Azfar, F; Badgett, W; Bae, T; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Barria, P; Bartos, P; Bauce, M; Bedeschi, F; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Bhatti, A; Bland, K R; Blumenfeld, B; Bocci, A; Bodek, A; Bortoletto, D; Boudreau, J; Boveia, A; Brigliadori, L; Bromberg, C; Brucken, E; Budagov, J; Budd, H S; Burkett, K; Busetto, G; Bussey, P; Butti, P; Buzatu, A; Calamba, A; Camarda, S; Campanelli, M; Canelli, F; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Cho, K; Chokheli, D; Clark, A; Clarke, C; Convery, M E; Conway, J; Corbo, M; Cordelli, M; Cox, C A; Cox, D J; Cremonesi, M; Cruz, D; Cuevas, J; Culbertson, R; d'Ascenzo, N; Datta, M; de Barbaro, P; Demortier, L; Deninno, M; D'Errico, M; Devoto, F; Di Canto, A; Di Ruzza, B; Dittmann, J R; Donati, S; D'Onofrio, M; Dorigo, M; Driutti, A; Ebina, K; Edgar, R; Elagin, A; Erbacher, R; Errede, S; Esham, B; Farrington, S; Fernández Ramos, J P; Field, R; Flanagan, G; Forrest, R; Franklin, M; Freeman, J C; Frisch, H; Funakoshi, Y; Galloni, C; Garfinkel, A F; Garosi, P; Gerberich, H; Gerchtein, E; Giagu, S; Giakoumopoulou, V; Gibson, K; Ginsburg, C M; Giokaris, N; Giromini, P; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldin, D; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González López, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gramellini, E; Grinstein, S; Grosso-Pilcher, C; Group, R C; Guimaraes da Costa, J; Hahn, S R; Han, J Y; Happacher, F; Hara, K; Hare, M; Harr, R F; Harrington-Taber, T; Hatakeyama, K; Hays, C; Heinrich, J; Herndon, M; Hocker, A; Hong, Z; Hopkins, W; Hou, S; Hughes, R E; Husemann, U; Hussein, M; Huston, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jang, D; Jayatilaka, B; Jeon, E J; Jindariani, S; Jones, M; Joo, K K; Jun, S Y; Junk, T R; Kambeitz, M; Kamon, T; Karchin, P E; Kasmi, A; Kato, Y; Ketchum, W; Keung, J; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S H; Kim, S B; Kim, Y J; Kim, Y K; Kimura, N; Kirby, M; Knoepfel, K; Kondo, K; Kong, D J; Konigsberg, J; Kotwal, A V; Kreps, M; Kroll, J; Kruse, M; Kuhr, T; Kurata, M; Laasanen, A T; Lammel, S; Lancaster, M; Lannon, K; Latino, G; Lee, H S; Lee, J S; Leo, S; Leone, S; Lewis, J D; Limosani, A; Lipeles, E; Lister, A; Liu, H; Liu, Q; Liu, T; Lockwitz, S; Loginov, A; Lucchesi, D; Lucà, A; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lys, J; Lysak, R; Madrak, R; Maestro, P; Malik, S; Manca, G; Manousakis-Katsikakis, A; Marchese, L; Margaroli, F; Marino, P; Martínez, M; Matera, K; Mattson, M E; Mazzacane, A; Mazzanti, P; McNulty, R; Mehta, A; Mehtala, P; Mesropian, C; Miao, T; Mietlicki, D; Mitra, A; Miyake, H; Moed, S; Moggi, N; Moon, C S; Moore, R; Morello, M J; Mukherjee, A; Muller, Th; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Naganoma, J; Nakano, I; Napier, A; Nett, J; Neu, C; Nigmanov, T; Nodulman, L; Noh, S Y; Norniella, O; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Ortolan, L; Pagliarone, C; Palencia, E; Palni, P; Papadimitriou, V; Parker, W; Pauletta, G; Paulini, M; Paus, C; Phillips, T J; Piacentino, G; Pianori, E; Pilot, J; Pitts, K; Plager, C; Pondrom, L; Poprocki, S; Potamianos, K; Pranko, A; Prokoshin, F; Ptohos, F; Punzi, G; Ranjan, N; Redondo Fernández, I; Renton, P; Rescigno, M; Rimondi, F; Ristori, L; Robson, A; Rodriguez, T; Rolli, S; Ronzani, M; Roser, R; Rosner, J L; Ruffini, F; Ruiz, A; Russ, J; Rusu, V; Sakumoto, W K; Sakurai, Y; Santi, L; Sato, K; Saveliev, V; Savoy-Navarro, A; Schlabach, P; Schmidt, E E; Schwarz, T; Scodellaro, L; Scuri, F; Seidel, S; Seiya, Y; Semenov, A; Sforza, F; Shalhout, S Z; Shears, T; Shepard, P F; Shimojima, M; Shochet, M; Shreyber-Tecker, I; Simonenko, A; Sliwa, K; Smith, J R; Snider, F D; Song, H; Sorin, V; St Denis, R; Stancari, M; Stentz, D; Strologas, J; Sudo, Y; Sukhanov, A; Suslov, I; Takemasa, K; Takeuchi, Y; Tang, J; Tecchio, M; Teng, P K; Thom, J; Thomson, E; Thukral, V; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Trovato, M; Ukegawa, F; Uozumi, S; Vázquez, F; Velev, G; Vellidis, C; Vernieri, C; Vidal, M; Vilar, R; Vizán, J; Vogel, M; Volpi, G; Wagner, P; Wallny, R; Wang, S M; Waters, D; Wester, W C; Whiteson, D; Wicklund, A B; Wilbur, S; Williams, H H; Wilson, J S; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, H; Wright, T; Wu, X; Wu, Z; Yamamoto, K; Yamato, D; Yang, T; Yang, U K; Yang, Y C; Yao, W-M; Yeh, G P; Yi, K; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Zanetti, A M; Zeng, Y; Zhou, C; Zucchelli, S

    2013-11-15

    We present a measurement of the total decay width of the top quark using events with top-antitop quark pair candidates reconstructed in the final state with one charged lepton and four or more hadronic jets. We use the full Tevatron run II data set of sqrt[s]=1.96  TeV proton-antiproton collisions recorded by the CDF II detector. The top quark mass and the mass of the hadronically decaying W boson are reconstructed for each event and compared with distributions derived from simulated signal and background samples to extract the top quark width (Γtop) and the energy scale of the calorimeter jets with in situ calibration. For a top quark mass Mtop=172.5  GeV/c2, we find 1.10quark width to date.

  5. Measurement of magnetic domain wall width using energy-filtered Fresnel images.

    Science.gov (United States)

    Lloyd, S J; Loudon, J C; Midgley, P A

    2002-08-01

    Magnetic domain walls in Nd2Fe14B have been examined using a series of energy-filtered Fresnel images in the field emission gun transmission electron microscope (FEGTEM). We describe the changes in the intensity distribution of the convergent wall image as a function of defocus, foil thickness and domain wall width. The effect of tilted domain walls and beam convergence on the fringe pattern is also discussed. A comparison of the experimental intensity profile with that from simulations allows the domain wall width to be determined. Measurement of very narrow walls is made possible only by using a relatively thick foil, which necessitates energy-filtering to allow quantitative comparison with simulations. The magnetic domain wall width in Nd2Fe14B was found to be 3 +/- 2 nm.

  6. Spatial Distribution of Stem Cell-Like Keratinocytes in Dissected Compound Hair Follicles of the Dog.

    Directory of Open Access Journals (Sweden)

    Dominique J Wiener

    Full Text Available Hair cycle disturbances are common in dogs and comparable to some alopecic disorders in humans. A normal hair cycle is maintained by follicular stem cells which are predominately found in an area known as the bulge. Due to similar morphological characteristics of the bulge area in humans and dogs, the shared particularity of compound hair follicles as well as similarities in follicular biomarker expression, the dog is a promising model to study human hair cycle and stem cell disorders. To gain insight into the spatial distribution of follicular keratinocytes with stem cell potential in canine compound follicles, we microdissected hair follicles in anagen and telogen from skin samples of freshly euthanized dogs. The keratinocytes isolated from different locations were investigated for their colony forming efficiency, growth and differentiation potential as well as clonal growth. Our results indicate that i compound and single hair follicles exhibit a comparable spatial distribution pattern with respect to cells with high growth potential and stem cell-like characteristics, ii the lower isthmus (comprising the bulge harbors most cells with high growth potential in both, the anagen and the telogen hair cycle stage, iii unlike in other species, colonies with highest growth potential are rather small with an irregular perimeter and iv the keratinocytes derived from the bulbar region exhibit characteristics of actively dividing transit amplifying cells. Our results now provide the basis to conduct comparative studies of normal dogs and those with hair cycle disorders with the possibility to extend relevant findings to human patients.

  7. Magnesium intracellular content and distribution map in drug-resistant and -sensitive whole cells

    Directory of Open Access Journals (Sweden)

    Emil Malucelli

    2014-01-01

    Full Text Available Magnesium (Mg plays crucial structural and regulatory roles within cells. Despite the extensive amount of data about the biochemistry of Mg, a complete picture of its regulation and cellular homeostasis is lacking. Thanks to recent improvements in third generation synchrotron X-ray sources, X-ray fluorescence microscopy (XRFM is becoming a highly sensitive method for mapping elemental distributions in cells. XRFM maps the element content but not the concentration, which is a relevant variable in a biological context. We tackled this issue by combining XRFM with atomic force microscopy that was used to obtain morphological information of the sample. The aim of the present study was to compare the content and the distribution of Mg in drug-resistant and -sensitive tumor cell lines. Our data has shown a massive increase of Mg in LoVo drug-resistant cells. Moreover, the map of intracellular Mg showed marked differences in the pattern distribution between sensitive and resistant cells.

  8. Detecting particles with cell phones: the Distributed Electronic Cosmic-ray Observatory

    CERN Document Server

    Vandenbroucke, Justin; Karn, Peter; Meehan, Matthew; Plewa, Matthew; Ruggles, Tyler; Schultz, David; Peacock, Jeffrey; Simons, Ariel Levi

    2015-01-01

    In 2014 the number of active cell phones worldwide for the first time surpassed the number of humans. Cell phone camera quality and onboard processing power (both CPU and GPU) continue to improve rapidly. In addition to their primary purpose of detecting photons, camera image sensors on cell phones and other ubiquitous devices such as tablets, laptops and digital cameras can detect ionizing radiation produced by cosmic rays and radioactive decays. While cosmic rays have long been understood and characterized as a nuisance in astronomical cameras, they can also be identified as a signal in idle camera image sensors. We present the Distributed Electronic Cosmic-ray Observatory (DECO), a platform for outreach and education as well as for citizen science. Consisting of an app and associated database and web site, DECO harnesses the power of distributed camera image sensors for cosmic-ray detection.

  9. Development of a charge-transfer distribution model for stack simulation of solid oxide fuel cells

    Science.gov (United States)

    Onaka, H.; Iwai, H.; Kishimoto, M.; Saito, M.; Yoshida, H.; Brus, G.; Szmyd, J. S.

    2016-09-01

    An overpotential model for planar solid oxide fuel cells (SOFCs) is developed and applied to a stack numerical simulation. Charge-transfer distribution within the electrodes are approximated using an exponential function, based on which the Ohmic loss and activation overpotential are evaluated. The predicted current-voltage characteristics agree well with the experimental results, and also the overpotentials within the cell can reproduce the results obtained from a numerical analysis where the distribution of the charge-transfer current within the electrodes is fully solved. The proposed model is expected to be useful to maintain the accuracy of SOFC simulations when the cell components, consisting of anode, electrolyte and cathode, are simplified into one layer element.

  10. Effects of Photovoltaic and Fuel Cell Hybrid System on Distribution Network Considering the Voltage Limits

    Directory of Open Access Journals (Sweden)

    ABYANEH, H. A.

    2010-11-01

    Full Text Available Development of distribution network and power consumption growth, increase voltage drop on the line impedance and therefore voltage drop in system buses. In some cases consumption is so high that voltage in some buses exceed from standard. In this paper, effect of the fuel cell and photovoltaic hybrid system on distribution network for solving expressed problem is studied. For determining the capacity of each distributed generation source, voltage limitation on the bus voltages under different conditions is considered. Simulation is done by using DIgSILENT software on the part of the 20 kV real life Sirjan distribution system. In this article, optimum location with regard to system and environmental conditions are studied in two different viewpoints.

  11. Distribution patterns of mast cells in the uterus of pregnant Meishan pigs.

    Science.gov (United States)

    Liu, Y X; Yu, M; Wang, C; Peng, K M; Liu, H Z

    2012-08-01

    The present study was performed to investigate the numerical distribution of mast cells (MCs) in the uteri of pregnant Meishan pigs to explore the functions of MCs in pig pregnancy. The uterine samples from pregnant (on days 15, 26 and 50 of gestation) pigs were obtained respectively and stained with toluidine blue. The results were as follows: MCs were constitutively located in the uterus of the Meishan pig, with the distribution varying with gestational stages. On days 15 and 26 of gestation, MCs were mainly distributed around the blood vessels and uterine glands within the endometrium. On day 50 of gestation, MCs were mostly distributed in the myometrium. These results indicated that uterine MCs possibly have versatile functions in pig pregnancy.

  12. Modeling spatial distribution of oxygen in 3d culture of islet beta-cells.

    Science.gov (United States)

    McReynolds, John; Wen, Yu; Li, Xiaofei; Guan, Jianjun; Jin, Sha

    2017-01-01

    Three-dimensional (3D) scaffold culture of pancreatic β-cell has been proven to be able to better mimic physiological conditions in the body. However, one critical issue with culturing pancreatic β-cells is that β-cells consume large amounts of oxygen, and hence insufficient oxygen supply in the culture leads to loss of β-cell mass and functions. This becomes more significant when cells are cultured in a 3D scaffold. In this study, in order to understand the effect of oxygen tension inside a cell-laden collagen culture on β-cell proliferation, a culture model with encapsulation of an oxygen-generator was established. The oxygen-generator was made by embedding hydrogen peroxide into nontoxic polydimethylsiloxane to avoid the toxicity of a chemical reaction in the β-cell culture. To examine the effectiveness of the oxygenation enabled 3D culture, the spatial-temporal distribution of oxygen tension inside a scaffold was evaluated by a mathematical modeling approach. Our simulation results indicated that an oxygenation-aided 3D culture would augment the oxygen supply required for the β-cells. Furthermore, we identified that cell seeding density and the capacity of the oxygenator are two critical parameters in the optimization of the culture. Notably, cell-laden scaffold cultures with an in situ oxygen supply significantly improved the β-cells' biological function. These β-cells possess high insulin secretion capacity. The results obtained in this work would provide valuable information for optimizing and encouraging functional β-cell cultures. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 33:221-228, 2017.

  13. Spatiotemporal analysis of endocytosis and membrane distribution of fluorescent sterols in living cells

    DEFF Research Database (Denmark)

    Wüstner, Daniel; Faergeman, Nils J

    2008-01-01

    (CTL) combined with advanced image analysis were used to study spatiotemporal sterol distribution in living macrophages, adipocytes and fibroblasts. Sterol endocytosis was directly visualized by time-lapse imaging and noise-robust tracking revealing confined motion of DHE containing vesicles in close...... proximity to the cell membrane. Spatial surface intensity patterns of DHE as well as that of the lipid marker DiIC12 being assessed by statistical image analysis persisted over several minutes in cells having a constant overall curvature. Sites of sterol endocytosis appeared indistinguishable from other...... regions of the cell surface, and endocytosis contributed by 62% to total sterol uptake in J774 cells. DHE co-localized with fluorescent transferrin (Tf) in vesicles right after onset of endocytosis and in deepened surface patches of energy depleted cells. Surface caveolae labeled with GFP-tagged caveolin...

  14. Pattern of distribution of blood group antigens on human epidermal cells during maturation

    DEFF Research Database (Denmark)

    Dabelsteen, Erik; Buschard, Karsten; Hakomori, Sen-Itiroh

    1984-01-01

    The distribution in human epidermis of A, B, and H blood group antigens and of a precursor carbohydrate chain, N-acetyl-lactosamine, was examined using immunofluorescence staining techniques. The material included tissue from 10 blood group A, 4 blood group B, and 9 blood group O persons. Murine...... on the lower spinous cells whereas H antigen was seen predominantly on upper spinous cells or on the granular cells. Epithelia from blood group A or B persons demonstrated A or B antigens, respectively, but only if the tissue sections were trypsinized before staining. In such cases A or B antigens were found...... monoclonal antibodies were used to identify H antigen (type 2 chain) and N-acetyl-lactosamine. Human antisera were used to identify A and B antigens. In all groups N-acetyl-lactosamine and H antigen were found on the cell membranes of the spinous cell layer. N-acetyl-lactosamine was present mainly...

  15. Light microscopical demonstration and zonal distribution of parasinusoidal cells (Ito cells) in normal human liver

    DEFF Research Database (Denmark)

    Horn, T; Junge, Jette; Nielsen, O;

    1988-01-01

    The parasinusoidal cells of the liver (Ito cells) were demonstrated light microscopically in autopsy specimens fixed in formalin and stained with Oil red O after dichromate treatment. The method allows examination of large samples containing numerous acini. Quantitative assessment showed a zonal...

  16. Controlling ρ width effects for a precise value of α in B → ρρ

    Science.gov (United States)

    Gronau, Michael; Rosner, Jonathan L.

    2017-03-01

    It has been pointed out that the currently most precise determination of the weak phase ϕ2 = α of the Cabibbo-Kobayashi-Maskawa (CKM) matrix achieved in B → ρρ decays is susceptible to a small correction at a level of (Γρ /mρ) 2 due to an I = 1 amplitude caused by the ρ width. Using Breit-Wigner distributions for the two pairs of pions forming ρ mesons, we study the I = 1 contribution to B → ρρ decay rates as function of the width and location of the ρ band. We find that in the absence of a particular enhancement of the I = 1 amplitude reducing a single band to a width Γρ at SuperKEKB leads to results which are completely insensitive to the ρ width. If the I = 1 amplitude is dynamically enhanced relative to the I = 0 , 2 amplitude one could subject its contribution to a "magnifying glass" measurement using two separated ρ bands of width Γρ. Subtraction of the I = 1 contribution from the measured decay rate would lead to a very precise determination of the I = 0 , 2 amplitude needed for performing the isospin analysis.

  17. Analysis of the distribution of the brain cells of the fruit fly by an automatic cell counting algorithm

    Science.gov (United States)

    Shimada, Takashi; Kato, Kentaro; Kamikouchi, Azusa; Ito, Kei

    2005-05-01

    The fruit fly is the smallest brain-having model animal. Its brain is said to consist only of about 250,000 neurons, whereas it shows “the rudiments of consciousness” in addition to its high abilities such as learning and memory. As the starting point of the exhaustive analysis of its brain-circuit information, we have developed a new algorithm of counting cells automatically from source 2D/3D figures. In our algorithm, counting cells is realized by embedding objects (typically, disks/balls), each of which has exclusive volume. Using this method, we have succeeded in counting thousands of cells accurately. This method provides us the information necessary for the analysis of brain circuits: the precise distribution of the whole brain cells.

  18. Minimal forbidden induced subgraphs of graphs of bounded clique-width and bounded linear clique-width

    OpenAIRE

    Meister, Daniel; Rotics, Udi

    2013-01-01

    In the study of full bubble model graphs of bounded clique-width and bounded linear clique-width, we determined complete sets of forbidden induced subgraphs, that are minimal in the class of full bubble model graphs. In this note, we show that (almost all of) these graphs are minimal in the class of all graphs. As a corollary, we can give sets of minimal forbidden induced subgraphs for graphs of bounded clique-width and for graphs of bounded linear clique-width for arbitrary bounds.

  19. Equivalent Widths of 15 Extrasolar-Planet Host Stars

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    We present the equivalent widths of 15 extrasolar-planet host stars.These data were based on the high-resolution, high signal-to-noise ratio spectra obtained with the 2.16 m telescope at Xinglong station. The error in the Xinglong equivalent width is estimated by a comparison of these data with those given in previous studies of common stars.

  20. Finite-width plasmonic waveguides with hyperbolic multilayer cladding

    DEFF Research Database (Denmark)

    Babicheva, Viktoriia; Shalaginov, Mikhail Y.; Ishii, Satoshi;

    2015-01-01

    homogenization, we calculate the resonant eigenmodes of the finite-width cladding layers, and find agreement with the resonant features in the dispersion of the cladded waveguides. We show that at the resonant widths, the propagating modes of the waveguides are coupled to the cladding eigenmodes and hence...

  1. Quantifying River Widths of North America from Satellite Imagery

    Science.gov (United States)

    Allen, G. H.; Pavelsky, T.; Miller, Z.

    2013-12-01

    River width is a fundamental predictor variable in many hydrologic, geomorphic, and biogeochemical models, yet current large-scale models rely on theoretical hydraulic geometry relationships that do not fully capture natural variability in river form. Here we present the first high-resolution dataset of long-term mean width of North American rivers wider than 30 m. The dataset contains 7.93 million georeferenced width measurements derived from Landsat TM and ETM+ imagery that were acquired when rivers were most likely to be at mean discharge. We built the dataset by developing an automated procedure that selects and downloads raw imagery, creates cloud-free normalized difference water index images, histogram balances and mosaics them together, and produces a water mask using a dynamic water-land threshold technique. We then visually inspected and corrected the mask for errors and used RivWidth software to calculate river width at each river centerline pixel. We validated our dataset using >1000 United States Geological Survey and Water Survey of Canada in situ gauge station measurements. Error analysis shows a robust relationship between the remotely sensed widths and in situ gauge measurements with an r 2 = 0.86 (Spearman's = 0.81) and a mean absolute error of 27.5 m. We find that North American river widths lie on logarithmic frequency curve with some notable exceptions at widths SWOT) satellite mission.

  2. Average widths of anisotropic Besov-Wiener classes

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    This paper concerns the problem of average σ-K width and average σ-L width of some anisotropic Besov-Wiener classes Srp q θb(Rd) and Srp q θB(Rd) in Lq(Rd) (1≤q≤p<∞). The weak asymptotic behavior is established for the corresponding quantities.

  3. Average widths of anisotropic Besov-Wiener classes

    Institute of Scientific and Technical Information of China (English)

    蒋艳杰

    2000-01-01

    This paper concems the problem of average σ-K width and average σ-L width of some anisotropic Besov-wiener classes Spqθr(Rd) and Spqθr(Rd) in Lq(Rd) (1≤≤q≤p<∞). The weak asymptotic behavior is established for the corresponding quantities.

  4. Interstitial cells of Cajal, macrophages and mast cells in the gut musculature: morphology, distribution, spatial and possible functional interactions.

    Science.gov (United States)

    Mikkelsen, Hanne B

    2010-04-01

    Interstitial cells of Cajal (ICC) are recognized as pacemaker cells for gastrointestinal movement and are suggested to be mediators of neuromuscular transmission. Intestinal motility disturbances are often associated with a reduced number of ICC and/or ultrastructural damage, sometimes associated with immune cells. Macrophages and mast cells in the intestinal muscularis externa of rodents can be found in close spatial contact with ICC. Macrophages are a constant and regularly distributed cell population in the serosa and at the level of Auerbach's plexus (AP). In human colon, ICC are in close contact with macrophages at the level of AP, suggesting functional interaction. It has therefore been proposed that ICC and macrophages interact. Macrophages and mast cells are considered to play important roles in the innate immune defence by producing pro-inflammatory mediators during classical activation, which may in itself result in damage to the tissue. They also take part in alternative activation which is associated with anti-inflammatory mediators, tissue remodelling and homeostasis, cancer, helminth infections and immunophenotype switch. ICC become damaged under various circumstances - surgical resection, possibly post-operative ileus in rodents - where innate activation takes place, and in helminth infections - where alternative activation takes place. During alternative activation the muscularis macrophage can switch phenotype resulting in up-regulation of F4/80 and the mannose receptor. In more chronic conditions such as Crohn's disease and achalasia, ICC and mast cells develop close spatial contacts and piecemeal degranulation is possibly triggered.

  5. Cell Area and Strut Distribution Changes of Bent Coronary Stents: A Finite Element Analysis

    Institute of Scientific and Technical Information of China (English)

    ZHAO Yang; WU Wei; YANG Da-zhi; QI Min

    2009-01-01

    Coronary stents are metal coils or mesh tubes delivered to blocked vessels through catheters, which are expanded by balloons to reopen and scaffold target vessels. Recently,special drugs are carried by stents (drug-eluting stents) to further reduce in-stent restenosis rate after stenting procedure. However,continual study on biomechanical characteristics of stents is necessary for better interactions between stents and tissue, or to provide a more suitable drug loading platform for drug-eluting stents. The purpose of this paper is to show how finite element methods can be used to study cell area and strut distribution changes of bent coronary stents. A same bending deformation was applied to two commercial coronary stent models by a rigid curved vessel. Results show that the stent design influenced the changes of cell area and strut distribution under bending situation. The stent with links had more cell area changes at outer curvature, and the stent with peak-peak (><) strut design could have strut contact and overlapping at inner curvature. In conclusion, this finite element method can be used to study and compare cell area and strut distribution changes of bent stents,and to provide a convenient tool for designers in testing and improving biomechanical characteristics of new stents.

  6. Distribution of S-100 positive dendritic cells in bovine pharynx,tonsils, and retropharyngeal lymph nodes

    Institute of Scientific and Technical Information of China (English)

    Jiaxin WANG; Haixia BIAN; Wei SHI; Zhanjun LU

    2008-01-01

    Dendritic cells (DCs) are professional antigen-presenting cells. However, the distribution of bovine DCs in the pharynx, tonsil, and retropharyngeal lymph nodes has not yet been documented. To address this issue, immunohistochemistry was conducted using S-100 pro-tein as a marker for DCs. It was observed that S-100 positive Langerhans cells (LCs) were primarily found in the basal layer of the pharyngeal epithelium. Some DCs were found in the outer layer of the epithelium and their dendrites extended out towards the epithelial surface. In the tonsil, S-100 positive DCs were found either in follicular germinal centers or in the T-cell areas. It is worth noting that the S-100 positive DCs were not only distributed in the cortex, but also in the medulla of bovine retropharyngeal lymph nodes. The distribution patterns of bovine DCs in the pharynx, tonsil, and retropharyngeal lymph nodes have an important implica-tion for our understanding of the interaction between pathogens and host.

  7. The distribution and redistribution of endoplasmic reticulum (ER) in geoperceptive cells.

    Science.gov (United States)

    Juniper, B E; French, A

    1972-09-01

    Within the root cap in maize the cells believed to be responsible for the perception of gravity possess a rough-surfaced ER system with a distinctive pattern of distribution. The ER is found normally parallel to the nuclear membrane and to the walls, and symmetrically distributed. It can be disturbed from its parallel position by moving the root to any horizontal orientation, but it is not displaced by inverting the root into the 180° vertical position. On returning to the normal position of growth the ER rapidly reforms into the original symmetrical position. The implications of this position and movement and the possible role of the ER are discussed.

  8. Spatiotemporal distribution and function of N-cadherin in postnatal Schwann cells: A matter of adhesion?

    DEFF Research Database (Denmark)

    Corell, Mikael; Wicher, Grzegorz; Limbach, Christoph;

    2010-01-01

    . In this study, we investigated the distribution of N-cadherin in the developing postnatal and adult rat peripheral nervous system. N-cadherin was found primarily in ensheathing glia throughout development, concentrated at neuron-glial or glial-glial contacts of the sciatic nerve, dorsal root ganglia (DRG......), and myenteric plexi. In the sciatic nerve, N-cadherin decreases with age and progress of myelination. In adult animals, N-cadherin was found exclusively in nonmyelinating Schwann cells. The distribution of N-cadherin in developing E17 DRG primary cultures is similar to what was observed in vivo. Functional...

  9. Crack widths in concrete with fibers and main reinforcement

    DEFF Research Database (Denmark)

    Christensen, Frede; Ulfkjær, Jens Peder; Brincker, Rune

    the ductility of the fiber reinforced concrete (FRC) is set up and experimental work is conducted in order to verify the crack width model. The ductility of the FRC is taken into account by using the stress crack width relation. The constitutive model for the FRC is based on the idea that the initial part......The main object of the research work presented in this paper is to establish design tools for concrete structures where main reinforcement is combined with addition of short discrete steel fibers. The work is concerned with calculating and measuring crack widths in structural elements subjected...... to bending load. Thus, the aim of the work is to enable engineers to calculate crack widths for flexural concrete members and analyze how different combinations of amounts of fibers and amounts of main reinforcement can meet a given maximum crack width requirement. A mathematical model including...

  10. The influence of sulcus width on simulated electric fields induced by transcranial magnetic stimulation

    Science.gov (United States)

    Janssen, A. M.; Rampersad, S. M.; Lucka, F.; Lanfer, B.; Lew, S.; Aydin, Ü.; Wolters, C. H.; Stegeman, D. F.; Oostendorp, T. F.

    2013-07-01

    Volume conduction models can help in acquiring knowledge about the distribution of the electric field induced by transcranial magnetic stimulation. One aspect of a detailed model is an accurate description of the cortical surface geometry. Since its estimation is difficult, it is important to know how accurate the geometry has to be represented. Previous studies only looked at the differences caused by neglecting the complete boundary between cerebrospinal fluid (CSF) and grey matter (Thielscher et al 2011 NeuroImage 54 234-43, Bijsterbosch et al 2012 Med. Biol. Eng. Comput. 50 671-81), or by resizing the whole brain (Wagner et al 2008 Exp. Brain Res. 186 539-50). However, due to the high conductive properties of the CSF, it can be expected that alterations in sulcus width can already have a significant effect on the distribution of the electric field. To answer this question, the sulcus width of a highly realistic head model, based on T1-, T2- and diffusion-weighted magnetic resonance images, was altered systematically. This study shows that alterations in the sulcus width do not cause large differences in the majority of the electric field values. However, considerable overestimation of sulcus width produces an overestimation of the calculated field strength, also at locations distant from the target location.

  11. Recombinant human erythropoietin increases cerebral cortical width index and neurogenesis following ischemic stroke

    Institute of Scientific and Technical Information of China (English)

    Zhongmin Wen; Peiji Wang

    2012-01-01

    The cerebral cortical expansion index refers to the ratio between left and right cortex width and is recognized as an indicator for cortical hyperplasia. Cerebral ischemia was established in CB-17 mice in the present study, and the mice were subsequently treated with recombinant human erythropoietin via subcutaneous injection. Results demonstrated that cerebral cortical width index significantly increased. Immunofluorescence detection showed that the number of nuclear antigen antibody/5-bromodeoxyuridine-positive cells at the infarction edge significantly increased. Correlation analysis revealed a negative correlation between neurological scores and cortical width indices in rats following ischemic stroke. These experimental findings suggested that recombinant human erythropoietin promoted cerebral cortical hyperplasia, increased cortical neurogenesis, and enhanced functional recovery following ischemic stroke.

  12. In vivo, multimodal imaging of B cell distribution and response to antibody immunotherapy in mice.

    Directory of Open Access Journals (Sweden)

    Daniel L J Thorek

    Full Text Available BACKGROUND: B cell depletion immunotherapy has been successfully employed to treat non-Hodgkin's lymphoma. In recent years, increasing attention has been directed towards also using B-cell depletion therapy as a treatment option in autoimmune disorders. However, it appears that the further development of these approaches will depend on a methodology to determine the relation of B-cell depletion to clinical response and how individual patients should be dosed. Thus far, patients have generally been followed by quantification of peripheral blood B cells, but it is not apparent that this measurement accurately reflects systemic B cell dynamics. METHODOLOGY/PRINCIPAL FINDINGS: Cellular imaging of the targeted population in vivo may provide significant insight towards effective therapy and a greater understanding of underlying disease mechanics. Superparamagnetic iron oxide (SPIO nanoparticles in concert with near infrared (NIR fluorescent dyes were used to label and track primary C57BL/6 B cells. Following antibody mediated B cell depletion (anti-CD79, NIR-only labeled cells were expeditiously cleared from the circulation and spleen. Interestingly, B cells labeled with both SPIO and NIR were not depleted in the spleen. CONCLUSIONS/SIGNIFICANCE: Whole body fluorescent tracking of B cells enabled noninvasive, longitudinal imaging of both the distribution and subsequent depletion of B lymphocytes in the spleen. Quantification of depletion revealed a greater than 40% decrease in splenic fluorescent signal-to-background ratio in antibody treated versus control mice. These data suggest that in vivo imaging can be used to follow B cell dynamics, but that the labeling method will need to be carefully chosen. SPIO labeling for tracking purposes, generally thought to be benign, appears to interfere with B cell functions and requires further examination.

  13. Distribution of 5-HT1F receptors in monkey vestibular and trigeminal ganglion cells

    Directory of Open Access Journals (Sweden)

    Habiba Usman

    2016-10-01

    Full Text Available Background: Evidence of serotonergic involvement in vestibular pathway contributions to migraine and balance disorders is compelling. Serotonergic 5-HT1B and 5-HT1D receptors are expressed extensively in inner ear ganglia of monkeys and rats. The serotonergic 5-HT1F receptor is also a target of triptans. This study describes its distribution in vestibular and trigeminal ganglia of monkeys. Methods: Using primary polyclonal antibodies raised against oligopeptides specific for the human 5-HT1F receptor, neuronal somatic area and intensity of immunoreactive vestibular and trigeminal ganglia were quantified. Results and Discussion: Virtually all vestibular and considerable trigeminal ganglia showed positive 5-HT1F receptor immunoreactivity. Inferior and superior vestibular ganglia staining appeared confined to distinct cell regions, varying considerably among cells of different sizes: more intense in small, punctate in some medium and regionally polarized in some large cells. Analyses of average somatic vestibular neuronal immunoreactive intensity identified mainly medium sized cells with high standard deviation of intensity corresponding to punctately-stained cells. Less variability occurred in somatic intensity staining and cellular distribution among 5-HT1F receptor immunopositive trigeminal ganglia. Most exhibited similar punctate staining patterns, higher mean somatic immunoreactive intensity and larger neuronal somatic size proportions per size distribution subpopulation compared to vestibular ganglia size distribution populations. Centrally directed vestibular ganglion neuronal processes, cochlear inner hair cells, vestibular hair cells and blood vessels in vestibular maculae and cristae were immunoreactive. The 5-HT1F receptor expression in vestibular ganglia shows complex variable staining intensity patterns associated with cell size of immunopositive neurons, not seen in immunopositive trigeminal ganglia and not previously evident with 5

  14. Distribution of immune response cells in the pelvic urethra and the prepuce of rams

    Directory of Open Access Journals (Sweden)

    Jorge Acosta-Dibarrat

    2014-03-01

    Full Text Available The pathogens of the reproductive system in the male can penetrate and establish by ascending route, from to the prepuce to the urethra, accessory glands, epididymis and testicles. The aim of this paper is determine the distribution and number of cells involved in the immune response in prepuce and pelvic urethra of rams, without apparent clinical alterations in testicle, epididymis and prepuce. The distribution of some of the cells involved in the immune response at the level of the prepuce and the pelvic urethra was quantified in four one-year-old rams seronegative for B. ovis and A. seminis and without apparent lesions in the testicles, the epididymis, and the prepuce. At the moment of slaughter, samples were taken from the preputial fornix and the pelvic urethra and placed in 10% formalin and under freezing conditions. CD4, CD8, WC1, CD45RO, CD14 and CD1b cells were demonstrated by immunohistochemistry, and immunoglobulin-containing cells (ICC of the IgA, IgG and IgM classes were demonstrated by immunofluorescence. The labeled cells present in the mucosa of both organs were counted with an image analyzer. The total number of cells was compared between both tissues and differentially between the epithelium and the connective tissue of the mucosa. Significant differences were found in the total number of CD4, CD45RO, and WC1 lymphocytes, in CD14 macrophages, and CD1b dendritic cells, with mean values being greater in the fornix than in the urethra (p<0.05 in all cases. Only dendritic cells were found in the prepuce. No differences were found in the number of CD8 lymphocytes between both organs. The ratio between each cell type in the connective and the intraepithelial tissues and between organs was 10/1 for CD4 in the fornix (p<0.05, against 7/1 in the urethra (p<0.05, while CD8 had a 1/1 distribution in both mucosae. The WC1 ratio was 5/1 in both mucosae (p<0.05. CD45RO labeling was 19/1 in the prepuce (p<0.05 and 1/1 in the urethra. Ig

  15. In situ hybridization of oxytocin messenger RNA: macroscopic distribution and quantitation in rat hypothalamic cell groups

    Energy Technology Data Exchange (ETDEWEB)

    Burbach, J.P.; Voorhuis, T.A.; van Tol, H.H.; Ivell, R.

    1987-05-29

    Oxytocin mRNA was detected in the rat hypothalamus by in situ hybridization to a single stranded /sup 35/S-labelled DNA probe and the distribution of oxytocin mRNA-containing cell groups was studied at the macroscopic level. Specificity of hybridization was confirmed by comparison to vasopressin mRNA hybridization in parallel tissue sections. Cell groups containing oxytocin mRNA were confined to a set of hypothalamic cell groups, i.c. the supraoptic, paraventricular, anterior commissural nuclei, nucleus circularis and scattered hypothalamic islets. These cell groups displayed similar densities of autoradiographic signals indicating that the oxytocin gene is expressed at approximately the same average level at these various sites.

  16. Voronoi Cell Patterns: Application of the size distribution to societal systems

    Science.gov (United States)

    Sathiyanarayanan, Rajesh; González, Diego Luis; Pimpinelli, Alberto; Einstein, T. L.

    2012-02-01

    In studying the growth of islands on a surface subjected to a particle flux, we found it useful to characterize the distribution of the areas of associated Voronoi (proximity or Wigner-Seitz) cells in terms of the generalized Wigner surmiseootnotetextAP & TLE, PRL 99 (2007) 226102; PRL 104 (2010) 149602 and the gamma distributions. Here we show that the same concepts and distributions are useful in analyzing several problems arising in society.ootnotetextDLG et al., arXiv 1109.3994; RS, Ph.D. dissertation; RS et al., preprint We analyze the 1D problem of the distribution of gaps between parked cars, assuming that successive cars park in the middle of vacant spaces, and compare with published data. We study the formation of second-level administrative divisions, e.g. French arrondissements. We study the actual distribution of arrondissements and the Voronoi tessellation associated with the chief town in each. While generally applicable, there are subtleties in some cases. Lastly, we consider the pattern formed by Paris M'etro stations and show that near the central area, the associated Voronoi construction also has this sort of distribution.

  17. Skew-Laplace and Cell-Size Distribution in Microbial Axenic Cultures: Statistical Assessment and Biological Interpretation

    Directory of Open Access Journals (Sweden)

    Olga Julià

    2010-01-01

    Full Text Available We report a skew-Laplace statistical analysis of both flow cytometry scatters and cell size from microbial strains primarily grown in batch cultures, others in chemostat cultures and bacterial aquatic populations. Cytometry scatters best fit the skew-Laplace distribution while cell size as assessed by an electronic particle analyzer exhibited a moderate fitting. Unlike the cultures, the aquatic bacterial communities clearly do not fit to a skew-Laplace distribution. Due to its versatile nature, the skew-Laplace distribution approach offers an easy, efficient, and powerful tool for distribution of frequency analysis in tandem with the flow cytometric cell sorting.

  18. Do bacterial cell numbers follow a theoretical Poisson distribution? Comparison of experimentally obtained numbers of single cells with random number generation via computer simulation.

    Science.gov (United States)

    Koyama, Kento; Hokunan, Hidekazu; Hasegawa, Mayumi; Kawamura, Shuso; Koseki, Shigenobu

    2016-12-01

    We investigated a bacterial sample preparation procedure for single-cell studies. In the present study, we examined whether single bacterial cells obtained via 10-fold dilution followed a theoretical Poisson distribution. Four serotypes of Salmonella enterica, three serotypes of enterohaemorrhagic Escherichia coli and one serotype of Listeria monocytogenes were used as sample bacteria. An inoculum of each serotype was prepared via a 10-fold dilution series to obtain bacterial cell counts with mean values of one or two. To determine whether the experimentally obtained bacterial cell counts follow a theoretical Poisson distribution, a likelihood ratio test between the experimentally obtained cell counts and Poisson distribution which parameter estimated by maximum likelihood estimation (MLE) was conducted. The bacterial cell counts of each serotype sufficiently followed a Poisson distribution. Furthermore, to examine the validity of the parameters of Poisson distribution from experimentally obtained bacterial cell counts, we compared these with the parameters of a Poisson distribution that were estimated using random number generation via computer simulation. The Poisson distribution parameters experimentally obtained from bacterial cell counts were within the range of the parameters estimated using a computer simulation. These results demonstrate that the bacterial cell counts of each serotype obtained via 10-fold dilution followed a Poisson distribution. The fact that the frequency of bacterial cell counts follows a Poisson distribution at low number would be applied to some single-cell studies with a few bacterial cells. In particular, the procedure presented in this study enables us to develop an inactivation model at the single-cell level that can estimate the variability of survival bacterial numbers during the bacterial death process.

  19. Distinctive left-sided distribution of adrenergic-derived cells in the adult mouse heart.

    Directory of Open Access Journals (Sweden)

    Kingsley Osuala

    Full Text Available Adrenaline and noradrenaline are produced within the heart from neuronal and non-neuronal sources. These adrenergic hormones have profound effects on cardiovascular development and function, yet relatively little information is available about the specific tissue distribution of adrenergic cells within the adult heart. The purpose of the present study was to define the anatomical localization of cells derived from an adrenergic lineage within the adult heart. To accomplish this, we performed genetic fate-mapping experiments where mice with the cre-recombinase (Cre gene inserted into the phenylethanolamine-n-methyltransferase (Pnmt locus were cross-mated with homozygous Rosa26 reporter (R26R mice. Because Pnmt serves as a marker gene for adrenergic cells, offspring from these matings express the β-galactosidase (βGAL reporter gene in cells of an adrenergic lineage. βGAL expression was found throughout the adult mouse heart, but was predominantly (89% located in the left atrium (LA and ventricle (LV (p<0.001 compared to RA and RV, where many of these cells appeared to have cardiomyocyte-like morphological and structural characteristics. The staining pattern in the LA was diffuse, but the LV free wall displayed intermittent non-random staining that extended from the apex to the base of the heart, including heavy staining of the anterior papillary muscle along its perimeter. Three-dimensional computer-aided reconstruction of XGAL+ staining revealed distribution throughout the LA and LV, with specific finger-like projections apparent near the mid and apical regions of the LV free wall. These data indicate that adrenergic-derived cells display distinctive left-sided distribution patterns in the adult mouse heart.

  20. Mast cells in common wolffish Anarhichas lupus L.: ontogeny, distribution and association with lymphatic vessels.

    Science.gov (United States)

    Hellberg, Hege; Bjerkås, Inge; Vågnes, Øyvind B; Noga, Edward J

    2013-12-01

    The morphology, ontogeny and tissue distribution of mast cells were studied in common wolffish(Anarhichas lupus L.) at the larval, juvenile and adult life stages using light and electron-microscopy and immunohistochemistry. Fish were sampled at 1 day, 1, 2, 3, 4, 8 and 12 weeks post-hatching in addition to 6 and 9 months and 2 years and older. From 8 weeks post-hatching, mast cells in common wolffish mainly appeared as oval or rounded cells 8-15 mm in diameter with an eccentrically placed, ovoid nucleus and filled with cytoplasmic granules up to 1.2 mm in diameter. Granules were refractile and eosinophilic to slightly basophilic in H&E and stained bright red with Martius-scarlet-blue and purple with pinacyanol erythrosinate in formalin-fixed tissues. Mast cells stained positive for piscidin 4 and Fc ε RI by immunohistochemistry. From 1 day to 4 weeks post-hatching, immature mast cell containing only a few irregularly sized cytoplasmic granules were observed by light and electron-microscopy in loose connective tissue of cranial areas. From 1 day post-hatching, these cells stained positive for piscidin 4 and Fc ε RI by immunohistochemistry. From 12 weeks post-hatching, mast cells showed a primarily perivascular distribution and were particularly closely associated with lymphatic vessels and sinuses. Mast cells were mainly located at the peripheral border of the adventitia of arteries and veins, while they were in intimate contact with the endothelium of the lymphatic vessels. Numerous mast cells were observed in the intestine. A stratum compactum, as described in salmonids, was not observed in wolffish intestine,nor were mast cells confined to a separate layer, a stratum granulosum. Lymphatic vessels consisting of endothelium, intimal connective tissue and a poorly developed basal lamina were observed in the intestine. Scanning electron microscopy was used to compare the structure and localization of intestinal mast cells of common wolffish and rainbow trout

  1. Enhanced invasion in vitro and the distribution patterns in vivo of CD133+ glioma stem cells

    Institute of Scientific and Technical Information of China (English)

    YU Sheng-ping; YANG Xue-jun; ZHANG Bin; MING Hao-lang; CHEN Cong; REN Bing-cheng; LIU Zhi-feng; LIU Bin

    2011-01-01

    Background Recent studies have suggested that cancer stem cells cause tumor recurrence based on their resistance to radiotherapy and chemotherapy.Although the highly invasive nature of glioblastoma cells is also implicated in the failure of current therapies,it is not clear whether cancer stem cells are involved in invasiveness.This study aimed to assess invasive ability of glioma stem cells (GSCs) derived from C6 glioma cell line and the distribution patterns of GSCs in Sprague-Dawley (SD) rat brain tumor.Methods Serum-free medium culture and magnetic isolation were used to gain purely CD133+ GSCs.The invasive stem cell markers and luxol fast blue staining for white matter tracts were performed to show the distribution patterns of GSCs in brain tumor of rats and the relationship among GSCs,vessels,and white matter tracts.The results of matrigel invasion assay were estimated using the Student's t test and the analysis of Western blotting was performed using the one-way analysis of variance (ANOVA) test.Results CD133+GSCs(number:85.3±4.1)were significantly more invasive in vitro than matched CD133- cells(number:25.9±3.1) (t=14.5,P <0.005).GSCs invaded into the brain diffusely and located in perivascular niche of tumor-brain interface or resided within perivascular niche next to white fiber tracts.The polarity of glioma cells containing GSCs was parallel to the white matter tracts.Conclusions Our data suggest that CD133+ GSCs exhibit more aggressive invasion in vitro and GSCs in vivo probably disseminate along the long axis of blood vessels and transit through the white matter tracts.The therapies targeting GSCs invasion combined with traditional glioblastoma multiforme therapeutic paradigms might be a new approach for avoiding malignant glioma recurrence.

  2. Distribution and density of mast cells in camel small intestine and influence of fixation techniques

    Directory of Open Access Journals (Sweden)

    MB Al-Zghoul

    2009-08-01

    Full Text Available This study was carried out to gather species-specific data on mast-cell density and distribution in camel small intestine under different fixation conditions and to elucidate the presence and cross-reactivity of tryptase in the camel small intestine using human specific anti-tryptase antibody. Tissue specimens from the jejunum, duodenum, and ileum were obtained from 9 healthy, 9-12 months old, male camels. Specimens were fixed either with carnoy’s fluid or formalinbuffered solution and stained with either methylene blue or immunohistochemically to identify mast cells. The present study demonstrated for the first time, the presence and cross-reactivity of tryptase in the camel small intestine using a specific mouse anti-human tryptase antibody. Mast cells were detected in all histological layers of the camel small intestine (mucosal, submucosal, muscularis externa and serosa. Among all locations examined in the duodenum, ileum and jejunum, no significant difference was observed in mast-cell counts among the lamina propria, muscularis mucosae, muscularis externa and the serosa. The only significant difference observed was the mast-cell count in submucosa region where the highest and lowest mast count was observed in the jejenual and ileal submucosa, respectively. Significant differences regarding the distribution of mast cell as well as the influence of the fixation method could be observed. This underlines the fact that data regarding mast cell heterogeneity from other species, obtained by different fixation methods, are not comparable. This fact has to be taken into account when evaluating mast cell subtypes under pathological conditions.

  3. Spatial distribution of prominin-1 (CD133-positive cells within germinative zones of the vertebrate brain.

    Directory of Open Access Journals (Sweden)

    József Jászai

    Full Text Available BACKGROUND: In mammals, embryonic neural progenitors as well as adult neural stem cells can be prospectively isolated based on the cell surface expression of prominin-1 (CD133, a plasma membrane glycoprotein. In contrast, characterization of neural progenitors in non-mammalian vertebrates endowed with significant constitutive neurogenesis and inherent self-repair ability is hampered by the lack of suitable cell surface markers. Here, we have investigated whether prominin-1-orthologues of the major non-mammalian vertebrate model organisms show any degree of conservation as for their association with neurogenic geminative zones within the central nervous system (CNS as they do in mammals or associated with activated neural progenitors during provoked neurogenesis in the regenerating CNS. METHODS: We have recently identified prominin-1 orthologues from zebrafish, axolotl and chicken. The spatial distribution of prominin-1-positive cells--in comparison to those of mice--was mapped in the intact brain in these organisms by non-radioactive in situ hybridization combined with detection of proliferating neural progenitors, marked either by proliferating cell nuclear antigen or 5-bromo-deoxyuridine. Furthermore, distribution of prominin-1 transcripts was investigated in the regenerating spinal cord of injured axolotl. RESULTS: Remarkably, a conserved association of prominin-1 with germinative zones of the CNS was uncovered as manifested in a significant co-localization with cell proliferation markers during normal constitutive neurogenesis in all species investigated. Moreover, an enhanced expression of prominin-1 became evident associated with provoked, compensatory neurogenesis during the epimorphic regeneration of the axolotl spinal cord. Interestingly, significant prominin-1-expressing cell populations were also detected at distinct extraventricular (parenchymal locations in the CNS of all vertebrate species being suggestive of further, non

  4. Tissue distribution of cells derived from the area opaca in heterospecific quail-chick blastodermal chimeras.

    Science.gov (United States)

    Karagenç, Levent; Sandikci, Mustafa

    2010-01-01

    The objective of the current study was to determine the tissue distribution of cells derived from the area opaca in heterospecific quail-chick blastodermal chimeras. Quail-chick chimeras were constructed by transferring dissociated cells from the area opaca of the stage X-XII (EG&K) quail embryo into the subgerminal cavity of the unincubated chick blastoderm. The distribution of quail cells in embryonic as well as extra-embryonic tissues of the recipient embryo were examined using the QCPN monoclonal antibody after 6 days of incubation in serial sections taken at 100-mum intervals. Data gathered in the present study demonstrated that, when introduced into the subgerminal cavity of a recipient embryo, cells of the area opaca are able to populate not only extra-embryonic structures such as the amnion and the yolk sac, but also various embryonic tissues derived from the ectoderm and less frequently the mesoderm. Ectodermal chimerism was confined mainly to the head region and was observed in tissues derived from the neural ectoderm and the surface ectoderm, including the optic cup, diencephalon and lens. Although the possibility of random incorporation of transplanted cells into these embryonic structures cannot be excluded, these results would suggest that area opaca, a peripheral ring of cells in the avian embryo destined to form the extra-embryonic ectoderm and endoderm of the yolk sac, might harbor cells that have the potential to give rise to various cell types in the recipient chick embryo, including those derived from the surface ectoderm and neural ectoderm.

  5. Analyzing the effects of surface distribution of pores in cell electroporation for a cell membrane containing cholesterol

    CERN Document Server

    Shil, Pratip; Vidyasagar, Pandit B

    2007-01-01

    This paper presents a model and numerical analysis of transmembrane potential induced in biological cell membrane under the influence of externally applied electric field (i.e., electroporation). This model differs from the established models in two distinct ways. Firstly, it incorporates the presence of cholesterol (~20% mole-fraction) in the membrane. Secondly, it considers the dependence of pore distribution on the variation of transmembrane potential from one region of the cell to the other. Formulation is based on the role of membrane tension and electrical forces in the formation of pores in a cell membrane, which is considered as an infinitesimally thin insulator. The model has been used to explore the creation and evolution of pores and to determine the number and size of pores as function of applied electric field (magnitude & duration). Results show that the presence of cholesterol enhances poration by changing the membrane tension. Analysis indicate that the number of pores, average pore radii ...

  6. A direct and at nanometer scale study of electrical charge distribution on membranes of alive cells

    Directory of Open Access Journals (Sweden)

    Marlière Christian

    2016-01-01

    Full Text Available In this paper is presented an innovative method to map in-vivo and at nanometer scale the electrical charge distribution on membranes of alive cells. It relies on a new atomic force microscopy (AFM mode based on an electro-mechanical coupling effect. Furthermore, an additional electrical signal detected by both the deflection of the AFM cantilever and simultaneous direct current measurements was detected at low scanning rates. It was attributed to the detection of the current stemming from ionic channels. It opens a new way to directly investigate in situ biological electrical surface processes involved in bacterial adhesion, biofilm formation, microbial fuel cells, etc.

  7. Distribution of Chromosome Breakpoints in Human Epithelial Cells Exposed to Low- and High-LET Radiations

    Science.gov (United States)

    Hada, Megumi; Cucinotta, Francis; Wu, Honglu

    2009-01-01

    The advantage of the multicolor banding in situ hybridization (mBAND) technique is not only its ability to identify simultaneously both inter- and intrachromosome exchanges, but also the ability to measure the breakpoint location along the length of the chromosome in a precision that is unmatched with other traditional banding techniques. Breakpoints on specific regions of a chromosome have been known to associate with specific cancers. The breakpoint distribution in cells after low- and high-LET radiation exposures will also provide the data for biophysical modeling of the chromatin structure, as well as the data for the modeling the formation of radiation-induced chromosome aberrations. In a series of experiments, we studied low- and high-LET radiation-induced chromosome aberrations using the mBAND technique with chromosome 3 painted in 23 different colored bands. Human epithelial cells (CH1 84B5F5/M10) were exposed in vitro to Cs- 137 rays at both low and high dose rates, secondary neutrons with a broad energy spectrum at a low dose rate and 600 MeV/u Fe ions at a high dose rate. The data of both inter- and intrachromosome aberrations involving the painted chromosome have been reported previously. Here we present data of the location of the chromosome breaks along the length of chromosome 3 in the cells after exposures to each of the four radiation scenarios. In comparison to the expected breakpoint distribution based on the length of the bands, the observed distribution appeared to be non-random for both the low- and high-LET radiations. In particular, hot spots towards both ends of the chromosome were found after low-LET irradiations of either low or high dose rates. For both high-LET radiation types (Fe ions and neutrons), the breakpoint distributions were similar, and were much smoother than that for low-LET radiation. The dependence of the breakpoint distribution on the radiation quality requires further investigations.

  8. A Preliminary Study on the Radiation dose Distribution in the Pyroprocess Hot Cell Environment

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Chankyu; Kim, Myung Soo; Kim, Giyoon; Lee, Eunjoong; Lee, Jeong Tae; Cho, Gyuseong [KAIST, Daejeon (Korea, Republic of); Ahn, Seongkyu; Park, Sehwan [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    Pyroprocessing is the promising technology for treatment of spent fuels. Because it is based on the collective recovery of TRU, it has an advantage in proliferation resistance compared to conventional aqueous processes. Development of pyroprocessing has positive effects to the public through reduction of the high-level radioactive waste and the effective use of energy resources. In Korea, Korea Atomic Energy Research Institute (KAERI) has researched pyroprocessing since 1997. The engineering scale integrated inactive pyroprocess facility (PRIDE) was constructed and test operation has been performed. A study on the preliminary conceptual design and cost estimation for a larger-scale model facility is in progress. The safeguards are essential in the pyroprocessing facility for proliferation resistance. To establish the reliable safeguards, the preliminary studies on radiation resistance requirements, assessment of the safeguards system applicability, and shielding of the safeguards equipment are required. Therefore, first of all, the radiation flux and dose distribution in hot cell environment have to be studied. The previous studies focused on the neutron flux at the pyroprocessing however they are limited to the individual unit process. In this study, the flux and dose distribution of neutron and gamma-ray in the hot cell environment of the pilot pyroprocessing facility are investigated. Based on the simplified material flow of pyroprocess, the material distribution model is established. In this study, the radiation flux and dose distribution in the hot cell environment of the pilot-scale pyroprocessing facility model is investigated preliminarily by the MCNP6 simulation. Based on the established material flow model, the material composition at each stage is calculated and used for the simulation. The simple hot cell structure and process batch size were assumed based on the previous studies.

  9. Numerical modelling of potential and current distributions in a bipolar electrolytic cell

    OpenAIRE

    Mitha, Eric; Froidevaux, Hubert

    2007-01-01

    This work deals with the modelling of electrochemical reactors with bipolar electrodes. We give a numerical model which enables us to compute electrical current and potential distributions in an electrochemical cell of any type of geometry in two and three dimensions, including electrodes at an unknown floating potential. We first present electrochemical reactors and particularly insist on kinetics and thermodynamics phenomena responsible on potential discontinuities at electrodes-electrolyte...

  10. Numerical modelling of potential and current distributions in a bipolar electrolytic cell

    OpenAIRE

    Mitha, Eric

    1998-01-01

    This work deals with the modelling of electrochemical reactors with bipolar electrodes. We give a numerical model which enables us to compute electrical current and potential distributions in an electrochemical cell of any type of geometry in two and three dimensions, including electrodes at an unknown floating potential. We first present electrochemical reactors and particularly insist on kinetics and thermodynamics phenomena responsible on potential discontinuities at electrodes-electrolyte...

  11. Width of gene expression profile drives alternative splicing.

    Directory of Open Access Journals (Sweden)

    Daniel Wegmann

    Full Text Available Alternative splicing generates an enormous amount of functional and proteomic diversity in metazoan organisms. This process is probably central to the macromolecular and cellular complexity of higher eukaryotes. While most studies have focused on the molecular mechanism triggering and controlling alternative splicing, as well as on its incidence in different species, its maintenance and evolution within populations has been little investigated. Here, we propose to address these questions by comparing the structural characteristics as well as the functional and transcriptional profiles of genes with monomorphic or polymorphic splicing, referred to as MS and PS genes, respectively. We find that MS and PS genes differ particularly in the number of tissues and cell types where they are expressed.We find a striking deficit of PS genes on the sex chromosomes, particularly on the Y chromosome where it is shown not to be due to the observed lower breadth of expression of genes on that chromosome. The development of a simple model of evolution of cis-regulated alternative splicing leads to predictions in agreement with these observations. It further predicts the conditions for the emergence and the maintenance of cis-regulated alternative splicing, which are both favored by the tissue specific expression of splicing variants. We finally propose that the width of the gene expression profile is an essential factor for the acquisition of new transcript isoforms that could later be maintained by a new form of balancing selection.

  12. What sets the minimum tokamak scrape-off layer width?

    Science.gov (United States)

    Joseph, Ilon

    2016-10-01

    The heat flux width of the tokamak scrape-off layer is on the order of the poloidal ion gyroradius, but the ``heuristic drift'' physics model is still not completely understood. In the absence of anomalous transport, neoclassical transport sets the minimum width. For plateau collisionality, the ion temperature width is set by qρi , while the electron temperature width scales as the geometric mean q(ρeρi) 1 / 2 and is close to qρi in magnitude. The width is enhanced because electrons are confined by the sheath potential and have a much longer time to radially diffuse before escaping to the wall. In the Pfirsch-Schluter regime, collisional diffusion increases the width by the factor (qR / λ) 1 / 2 where qR is the connection length and λ is the mean free path. This qualitatively agrees with the observed transition in the scaling law for detached plasmas. The radial width of the SOL electric field is determined by Spitzer parallel and ``neoclassical'' radial electric conductivity and has a similar scaling to that for thermal transport. Prepared under US DOE contract DE-AC52-07NA27344.

  13. Step width alters iliotibial band strain during running.

    Science.gov (United States)

    Meardon, Stacey A; Campbell, Samuel; Derrick, Timothy R

    2012-11-01

    This study assessed the effect of step width during running on factors related to iliotibial band (ITB) syndrome. Three-dimensional (3D) kinematics and kinetics were recorded from 15 healthy recreational runners during overground running under various step width conditions (preferred and at least +/- 5% of their leg length). Strain and strain rate were estimated from a musculoskeletal model of the lower extremity. Greater ITB strain and strain rate were found in the narrower step width condition (p < 0.001, p = 0.040). ITB strain was significantly (p < 0.001) greater in the narrow condition than the preferred and wide conditions and it was greater in the preferred condition than the wide condition. ITB strain rate was significantly greater in the narrow condition than the wide condition (p = 0.020). Polynomial contrasts revealed a linear increase in both ITB strain and strain rate with decreasing step width. We conclude that relatively small decreases in step width can substantially increase ITB strain as well as strain rates. Increasing step width during running, especially in persons whose running style is characterized by a narrow step width, may be beneficial in the treatment and prevention of running-related ITB syndrome.

  14. Performance influence in submersible pump with different diffuser inlet widths

    Directory of Open Access Journals (Sweden)

    Qingshun Wei

    2016-12-01

    Full Text Available The diffuser inlet width is a key geometric parameter that affects submersible pump performance. On the basis of diffuser characteristic curve analyses, diffusers with different inlet widths and the same impeller were equipped to construct a submersible pump model through the use of AutoCAD software. The performance curves of the submersible pump, with six diffuser inlet widths, were obtained using computational fluid dynamics method. Simultaneously, the simulation results were tested with the experimental method presented in this article. The results show that the optimum value of the inlet width (b3 = 50 mm is larger than the experience-based one. With an increase in the inlet width, the optimum operating point of a submersible pump offsets to a larger flow rate. When the guide blade inlet width is approximately 40–55 mm, the submersible pump efficiency is relatively high, approximately 75.9%–83.7% capacity, and the flow rate is approximately 105–135 m3/h. The numerical results of submersible pump performance are higher than those of the test results; however, their change trends have an acceptable agreement with each other. The practical significance is supplied by changing the inlet width of the diffuser to expand the scope of use.

  15. [Distribution of compact bone mesenchymal stem cells in lung tissue and bone marrow of mouse].

    Science.gov (United States)

    Wang, Rui-Ping; Wu, Ren-Na; Guo, Yu-Qing; Zhang, Bin; Chen, Hu

    2014-02-01

    This study was aimed to investigate the distribution of compact bone mesenchymal stem cells(MSC) marked with lentiviral plasmid pGC FU-RFP-LV in lung tissue and bone marrow of mouse. The MSC were infected by lentivirus with infection efficiency 78%, the infected MSC were injected into BALB/c mice via tail veins in concentration of 1×10(6) /mouse. The mice were randomly divided into 4 group according to 4 time points as 1, 2, 5 and 7 days. The lung tissue and bone marrow were taken and made of frozen sections and smears respectively in order to observed the distributions of MSC. The results indicated that the lentiviral infected MSC displayed phenotypes and biological characteristics which conformed to MSC by immunophenotyping analysis and induction differentiation detection. After the MSC were infected with optimal viral titer MOI = 50, the cell growth no significantly changed; the fluorescent microscopy revealed that the distributions of MSC in bone marrow on day 1, 2, 5 and 7 were 0.50 ± 0.20, 0.67 ± 0.23, 0.53 ± 0.14, 0.33 ± 0.16; those in lung tissue were 0.55 ± 0.15, 0.47 ± 0.13, 0.29 ± 0.13, 0.26 ± 0.08. It is concluded that the distribution of MSC in lung tissue reaches a peak on day 1, while distribution of MSC in bone marrow reaches a peak on day 2. The distribution of mouse MSC relates with RFP gene expression and implantation of MSC in lung tissue and bone marrow.

  16. Assessment of dye distribution in sensitized solar cells by microprobe techniques

    Energy Technology Data Exchange (ETDEWEB)

    Barreiros, M.A., E-mail: alexandra.barreiros@lneg.pt [Laboratório Nacional de Energia e Geologia, LEN/UES, Estrada do Paço do Lumiar, 22, 1649-038 Lisboa (Portugal); Corregidor, V. [IPFN, Instituto Superior Técnico, Universidade de Lisboa, E.N. 10, 2686-953 Sacavém (Portugal); Alves, L.C. [C2TN, Campus Tecnológico e Nuclear, Instituto Superior Técnico, Universidade de Lisboa, E.N. 10, 2686-953 Sacavém (Portugal); Guimarães, F. [Laboratório Nacional de Energia e Geologia, LGM/UCTM, Rua da Amieira, Apartado 1089, 4466-901 S. Mamede de Infesta (Portugal); Mascarenhas, J.; Torres, E.; Brites, M.J. [Laboratório Nacional de Energia e Geologia, LEN/UES, Estrada do Paço do Lumiar, 22, 1649-038 Lisboa (Portugal)

    2015-04-01

    Dye sensitized solar cells (DSCs) have received considerable attention once this technology offers economic and environmental advantages over conventional photovoltaic (PV) devices. The PV performance of a DSC relies on the characteristics of its photoanode, which typically consists of a nanocrystalline porous TiO{sub 2} film, enabled with a large adsorptive surface area. Dye molecules that capture photons from light during device operation are attached to the film nanoparticles. The effective loading of the dye in the TiO{sub 2} electrode is of paramount relevance for controlling and optimizing solar cell parameters. Relatively few methods are known today for quantitative evaluation of the total dye adsorbed on the film. In this context, microprobe techniques come out as suitable tools to evaluate the dye surface distribution and depth profile in sensitized films. Electron Probe Microanalysis (EPMA) and Ion Beam Analytical (IBA) techniques using a micro-ion beam were used to quantify and to study the distribution of the Ru organometallic dye in TiO{sub 2} films, making use of the different penetration depth and beam sizes of each technique. Different 1D nanostructured TiO{sub 2} films were prepared, morphologically characterized by SEM, sensitized and analyzed by the referred techniques. Dye load evaluation in different TiO{sub 2} films by three different techniques (PIXE, RBS and EPMA/WDS) provided similar results of Ru/Ti mass fraction ratio. Moreover, it was possible to assess dye surface distribution and its depth profile, by means of Ru signal, and to visualize the dye distribution in sample cross-section through X-ray mapping by EPMA/EDS. PIXE maps of Ru and Ti indicated an homogeneous surface distribution. The assessment of Ru depth profile by RBS showed that some films have homogeneous Ru depth distribution while others present different Ru concentration in the top layer (2 μm thickness). These results are consistent with the EPMA/EDS maps obtained.

  17. Assessment of dye distribution in sensitized solar cells by microprobe techniques

    Science.gov (United States)

    Barreiros, M. A.; Corregidor, V.; Alves, L. C.; Guimarães, F.; Mascarenhas, J.; Torres, E.; Brites, M. J.

    2015-04-01

    Dye sensitized solar cells (DSCs) have received considerable attention once this technology offers economic and environmental advantages over conventional photovoltaic (PV) devices. The PV performance of a DSC relies on the characteristics of its photoanode, which typically consists of a nanocrystalline porous TiO2 film, enabled with a large adsorptive surface area. Dye molecules that capture photons from light during device operation are attached to the film nanoparticles. The effective loading of the dye in the TiO2 electrode is of paramount relevance for controlling and optimizing solar cell parameters. Relatively few methods are known today for quantitative evaluation of the total dye adsorbed on the film. In this context, microprobe techniques come out as suitable tools to evaluate the dye surface distribution and depth profile in sensitized films. Electron Probe Microanalysis (EPMA) and Ion Beam Analytical (IBA) techniques using a micro-ion beam were used to quantify and to study the distribution of the Ru organometallic dye in TiO2 films, making use of the different penetration depth and beam sizes of each technique. Different 1D nanostructured TiO2 films were prepared, morphologically characterized by SEM, sensitized and analyzed by the referred techniques. Dye load evaluation in different TiO2 films by three different techniques (PIXE, RBS and EPMA/WDS) provided similar results of Ru/Ti mass fraction ratio. Moreover, it was possible to assess dye surface distribution and its depth profile, by means of Ru signal, and to visualize the dye distribution in sample cross-section through X-ray mapping by EPMA/EDS. PIXE maps of Ru and Ti indicated an homogeneous surface distribution. The assessment of Ru depth profile by RBS showed that some films have homogeneous Ru depth distribution while others present different Ru concentration in the top layer (2 μm thickness). These results are consistent with the EPMA/EDS maps obtained.

  18. Distribution, Arrangement and Interconnectedness of Cell Surface Receptor sites in the body of an Organism

    Directory of Open Access Journals (Sweden)

    Utoh-Nedosa

    2011-01-01

    Full Text Available Cell surface receptors have been identified as the sites of disease infectivity in living organisms in a previous study. Drugs used for the treatment or cure of infections have to eliminate infections through attacking infective organisms at the cell surface receptors to which the infective organisms are attached. Problem statement: The present study examines a wide sample of living things to get more information on the relationship of one cell surface receptor to other cell surface receptors in the body of an organism. Approach: The arrangement of cell surface receptors on the external covering of a few samples of fruits, leaves, stems, dry wood of a plant; wall gecko and some parts of the human body, were examined and photographed. Transverse and/or Longitudinal sections of soursop fruit and sycamore fruit were also examined and photographed. The five different coverings of the fleshy part of a coconut were also photographed. The photographs were studied to note the relationship of disease infection attached to cell surface receptors on the external surface of an organ to disease infection on the innermost covering of the same organ. Results: The results of the study showed that all living things had ubiquitous distribution of cell surface receptors which are usually observable with the unaided eye as dots or spots on the external covering of an organ, tissue or cell. The dots or receptor sites of cell surface receptors in the study are arranged in lines which were perpendicular, oblique, transverse or arranged in any other lineal geometrical form. The lineally arranged cell surface receptors were noted to be connected by grooves, channels or pipes which joined other receptor channels or intersected with them. Smaller cell surface receptor channels emptied into bigger channels or continued as small sized channels that ran side by side in a connective tissue bundle. These connective tissue bundles that carried many independent small-sized cell

  19. Sediment dynamics in restored riparian forest with different widths and agricultural surroundings

    Science.gov (United States)

    Stucchi Boschi, Raquel; Simões da Silva, Laura; Ribeiro Rodrigues, Ricardo; Cooper, Miguel

    2016-04-01

    The riparian forests are essential to maintaining the quality of water resources, aquifer recharge and biodiversity. Due to the ecological services provided by riparian forests, these areas are considered by the law as Permanent Preservation Areas, being mandatory maintenance and restoration. However, the obligation of restoration and the extent of the Permanent Preservation Areas as defined by the Brazilian Forest Code, based on water body width, elucidates the lack of accurate scientific data on the influence of the size of the riparian forest in maintaining their ecological functions, particularly regarding the retention of sediments. Studies that evaluate the ideal width of riparian forests to guarantee their ecological functions are scarce and not conclusive, especially when we consider newly restored forests, located in agricultural areas. In this study, we investigate the dynamics of erosion and sedimentation in restored riparian forests with different widths situated in agricultural areas. The two study areas are located in a Semideciduous Tropical Forest inserted in sugarcane landscapes of São Paulo state, Brazil. The installed plots had 60 and 100 m in length and the riparian forest has a width of 15, 30 and 50 m. The characteristics of the sediments inside the plots were evaluated by detailed morphological and micromorphological studies as well as physical characterization. The dynamics of deposition and the amount of deposited sediments have been assessed with graded metal stakes partially buried inside the plots. The intensity, frequency and distribution of rainfall, as well as the occurrence of extreme events, have been evaluated by data collected from rain gauges installed in the areas. We expect that smaller widths are not able to retain sediments originated from the adjacent sugarcane areas. We also believe that extreme events are responsible for generating most of the sediments. The results will be important to support the discussion about an

  20. Distributed coupling and multi-frequency microwave accelerators

    Science.gov (United States)

    Tantawi, Sami G.; Li, Zenghai; Borchard, Philipp

    2016-07-05

    A microwave circuit for a linear accelerator has multiple metallic cell sections, a pair of distribution waveguide manifolds, and a sequence of feed arms connecting the manifolds to the cell sections. The distribution waveguide manifolds are connected to the cell sections so that alternating pairs of cell sections are connected to opposite distribution waveguide manifolds. The distribution waveguide manifolds have concave modifications of their walls opposite the feed arms, and the feed arms have portions of two distinct widths. In some embodiments, the distribution waveguide manifolds are connected to the cell sections by two different types of junctions adapted to allow two frequency operation. The microwave circuit may be manufactured by making two quasi-identical parts, and joining the two parts to form the microwave circuit, thereby allowing for many manufacturing techniques including electron beam welding, and thereby allowing the use of un-annealled copper alloys, and hence greater tolerance to high gradient operation.

  1. Quantitative Changes in Microtubule Distribution Correlate with Guard Cell Function in Arabidopsis

    Institute of Scientific and Technical Information of China (English)

    William R. Eisinger; Viktor Kirik; Charlotte Lewis; David W. Ehrhardt; Winslow R. Briggs

    2012-01-01

    Radially arranged cortical microtubules are a prominent feature of guard cells.We observed guard cells expressing GFP-tubulin (GFP-TUA6) with confocal microscopy and found recognizable changes in the appearance of microtubules when stomata open or close (Eisinger et al.,2012).In the present study,analysis of fluorescence distribution showed a dramatic increase in peak intensities of microtubule bundles within guard cells as stomata open.This increase was correlated with an increase in the total fluorescence that could be attributed to polymerized tubulin.Adjacent pavement cells did not show similar changes in peak intensities or integrated fluorescence when stomatal apertures changed.Imaging of RFP-tagged end binding protein 1 (EB1) and YFP-tagged α-tubulin expressed in the same cell revealed that the number of microtubules with growing ends remained constant,although the total amount of polymerized tubulin was higher in open than in closed guard cells.Taken together,these results indicate that the changes in microtubule array organization that are correlated with and required for normal guard cell function are characterized by changes in microtubule clustering or bundling.

  2. Lateral current effects on the voltage distribution in the emitter of solar cells under concentrated sunlight

    Energy Technology Data Exchange (ETDEWEB)

    Morales-Acevedo, Arturo [CINVESTAV-IPN, Electrical Engineering Department, Avenida IPN No. 2508, 07360 Mexico, DF (Mexico)

    2009-04-15

    The design of the grid contact in silicon solar cells is one of the most important steps for the optimization and fabrication of these energy conversion devices. The voltage drop due to the lateral flow of current towards the grid fingers can be a limiting factor causing the reduction of conversion efficiency. For low current levels this voltage drop can be made small, for typical values of sheet resistance in the emitter, but for solar cells made to operate at high sun concentrations this efficiency loss can be important, unless there is a clear vision of the current and voltage distribution so that the emitter and grid design can be improved. Hence, it is important to establish and solve the current and voltage distribution equations for solar cells with a grid contact. In this work, first these equations are established and then they are solved in order to show the effects that the lateral current flow in the emitter cause on the voltage distribution, particularly at high illumination levels. In addition, it will be shown that the open circuit voltage is significantly reduced due to the lateral current flow as compared to the value predicted from a simple equivalent circuit with a lumped resistance model. (author)

  3. Índice de anisocitose eritrocitária (RDW): diferenciação das anemias microcíticas e hipocrômicas Red blood cell distribution width (RDW): differentiation of microcytic and hypochromic anemias

    OpenAIRE

    Matos,Januária F.; Dusse,Luci M. S.; Rachel V. B. Stubbert; Geralda F. G. Lages; Maria das Graças Carvalho

    2008-01-01

    A anemia ferropriva, talassemia menor e anemia de doença crônica são as anemias microcíticas e hipocrômicas mais comuns em nosso meio. O diagnóstico diferencial das referidas anemias é de grande importância clínica; contudo, muitas vezes é complexo em virtude de concomitância de doenças, além de demandar tempo e apresentar custos significativos. Com o propósito de conferir maior simplicidade e eficiência ao diagnóstico diferencial destas anemias, o uso de índices derivados de modernos contado...

  4. The spatial distribution of LGR5+ cells correlates with gastric cancer progression.

    Directory of Open Access Journals (Sweden)

    Eva Simon

    Full Text Available In this study we tested the prevalence, histoanatomical distribution and tumour biological significance of the Wnt target protein and cancer stem cell marker LGR5 in tumours of the human gastrointestinal tract. Differential expression of LGR5 was studied on transcriptional (real-time polymerase chain reaction and translational level (immunohistochemistry in malignant and corresponding non-malignant tissues of 127 patients comprising six different primary tumour sites, i.e. oesophagus, stomach, liver, pancreas, colon and rectum. The clinico-pathological significance of LGR5 expression was studied in 100 patients with gastric carcinoma (GC. Non-neoplastic tissue usually harboured only very few scattered LGR5(+ cells. The corresponding carcinomas of the oesophagus, stomach, liver, pancreas, colon and rectum showed significantly more LGR5(+ cells as well as significantly higher levels of LGR5-mRNA compared with the corresponding non-neoplastic tissue. Double staining experiments revealed a coexpression of LGR5 with the putative stem cell markers CD44, Musashi-1 and ADAM17. Next we tested the hypothesis that the sequential changes of gastric carcinogenesis, i.e. chronic atrophic gastritis, intestinal metaplasia and invasive carcinoma, are associated with a reallocation of the LGR5(+ cells. Interestingly, the spatial distribution of LGR5 changed: in non-neoplastic stomach mucosa, LGR5(+ cells were found predominantly in the mucous neck region; in intestinal metaplasia LGR5(+ cells were localized at the crypt base, and in GC LGR5(+ cells were present at the luminal surface, the tumour centre and the invasion front. The expression of LGR5 in the tumour centre and invasion front of GC correlated significantly with the local tumour growth (T-category and the nodal spread (N-category. Furthermore, patients with LGR5(+ GCs had a shorter median survival (28.0±8.6 months than patients with LGR5(- GCs (54.5±6.3 months. Our results show that LGR5 is

  5. Altered distribution of peripheral blood memory B cells in humans chronically infected with Trypanosoma cruzi.

    Directory of Open Access Journals (Sweden)

    Esteban R Fernández

    Full Text Available Numerous abnormalities of the peripheral blood T cell compartment have been reported in human chronic Trypanosoma cruzi infection and related to prolonged antigenic stimulation by persisting parasites. Herein, we measured circulating lymphocytes of various phenotypes based on the differential expression of CD19, CD4, CD27, CD10, IgD, IgM, IgG and CD138 in a total of 48 T. cruzi-infected individuals and 24 healthy controls. Infected individuals had decreased frequencies of CD19+CD27+ cells, which positively correlated with the frequencies of CD4+CD27+ cells. The contraction of CD19+CD27+ cells was comprised of IgG+IgD-, IgM+IgD- and isotype switched IgM-IgD- memory B cells, CD19+CD10+CD27+ B cell precursors and terminally differentiated CD19+CD27+CD138+ plasma cells. Conversely, infected individuals had increased proportions of CD19+IgG+CD27-IgD- memory and CD19+IgM+CD27-IgD+ transitional/naïve B cells. These observations prompted us to assess soluble CD27, a molecule generated by the cleavage of membrane-bound CD27 and used to monitor systemic immune activation. Elevated levels of serum soluble CD27 were observed in infected individuals with Chagas cardiomyopathy, indicating its potentiality as an immunological marker for disease progression in endemic areas. In conclusion, our results demonstrate that chronic T. cruzi infection alters the distribution of various peripheral blood B cell subsets, probably related to the CD4+ T cell deregulation process provoked by the parasite in humans.

  6. Altered distribution of peripheral blood memory B cells in humans chronically infected with Trypanosoma cruzi.

    Science.gov (United States)

    Fernández, Esteban R; Olivera, Gabriela C; Quebrada Palacio, Luz P; González, Mariela N; Hernandez-Vasquez, Yolanda; Sirena, Natalia María; Morán, María L; Ledesma Patiño, Oscar S; Postan, Miriam

    2014-01-01

    Numerous abnormalities of the peripheral blood T cell compartment have been reported in human chronic Trypanosoma cruzi infection and related to prolonged antigenic stimulation by persisting parasites. Herein, we measured circulating lymphocytes of various phenotypes based on the differential expression of CD19, CD4, CD27, CD10, IgD, IgM, IgG and CD138 in a total of 48 T. cruzi-infected individuals and 24 healthy controls. Infected individuals had decreased frequencies of CD19+CD27+ cells, which positively correlated with the frequencies of CD4+CD27+ cells. The contraction of CD19+CD27+ cells was comprised of IgG+IgD-, IgM+IgD- and isotype switched IgM-IgD- memory B cells, CD19+CD10+CD27+ B cell precursors and terminally differentiated CD19+CD27+CD138+ plasma cells. Conversely, infected individuals had increased proportions of CD19+IgG+CD27-IgD- memory and CD19+IgM+CD27-IgD+ transitional/naïve B cells. These observations prompted us to assess soluble CD27, a molecule generated by the cleavage of membrane-bound CD27 and used to monitor systemic immune activation. Elevated levels of serum soluble CD27 were observed in infected individuals with Chagas cardiomyopathy, indicating its potentiality as an immunological marker for disease progression in endemic areas. In conclusion, our results demonstrate that chronic T. cruzi infection alters the distribution of various peripheral blood B cell subsets, probably related to the CD4+ T cell deregulation process provoked by the parasite in humans.

  7. [Calcium distribution in the central cell of lettuce (Lactuca sativa L.) before and after pollination].

    Science.gov (United States)

    Qiu, Yi Lan; Liu, Ru Shi; Ye, Lv; Tian, Hui

    2008-02-01

    Potassium antimonite precipitation was used to locate calcium in the central cell of lettuce (Lactuca sativa L.) before and after pollination. At 3d before anthesis, two polar nuclei of central cell separately located at two polarity of the cell, and few calcium precipitates (ppts) appeared in the polar nuclei and cytoplasm, but some ppts in its small vacuoles. At 2d before anthesis, two polar nuclei moved toward the middle of the cell and fused to form a secondary nucleus, and the ppts evidently increased in the nucleus and cytoplasm. At 1d before anthesis, secondary nucleus again moved toward micropylar end and located near the egg to prepare for fertilization. Calcium precipitates were mainly accumulated in the secondary nucleus. After pollination and before fertilization, the distribution of calcium ppts was similar to that before pollination. At 4h after pollination, the central cell was fertilized, and calcium ppts evidently increased in the cell and numerous were accumulated in its nucleus and cytoplasm. At 6h after pollination, the primary endosperm nucleus completed its first division and formed two dissociate endosperm nuclei, and still many calcium precipitates appeared in the nucleus and cytoplasm. With endosperm development, calcium ppts decreased in the endosperm cell. At 1d after emasculated and without pollination, the secondary nucleus of the cell still bordered on the egg and some calcium ppts appeared in the secondary nucleus. The results indicated that the temporal and spatial changes of calcium in the central cell may play an important physiological role during the development of the central cell and endosperm.

  8. Complexity of the tensegrity structure for dynamic energy and force distribution of cytoskeleton during cell spreading.

    Directory of Open Access Journals (Sweden)

    Ting-Jung Chen

    Full Text Available Cytoskeleton plays important roles in intracellular force equilibrium and extracellular force transmission from/to attaching substrate through focal adhesions (FAs. Numerical simulations of intracellular force distribution to describe dynamic cell behaviors are still limited. The tensegrity structure comprises tension-supporting cables and compression-supporting struts that represent the actin filament and microtubule respectively, and has many features consistent with living cells. To simulate the dynamics of intracellular force distribution and total stored energy during cell spreading, the present study employed different complexities of the tensegrity structures by using octahedron tensegrity (OT and cuboctahedron tensegrity (COT. The spreading was simulated by assigning specific connection nodes for radial displacement and attachment to substrate to form FAs. The traction force on each FA was estimated by summarizing the force carried in sounding cytoskeletal elements. The OT structure consisted of 24 cables and 6 struts and had limitations soon after the beginning of spreading by declining energy stored in struts indicating the abolishment of compression in microtubules. The COT structure, double the amount of cables and struts than the OT structure, provided sufficient spreading area and expressed similar features with documented cell behaviors. The traction force pointed inward on peripheral FAs in the spread out COT structure. The complex structure in COT provided further investigation of various FA number during different spreading stages. Before the middle phase of spreading (half of maximum spreading area, cell attachment with 8 FAs obtained minimized cytoskeletal energy. The maximum number of 12 FAs in the COT structure was required to achieve further spreading. The stored energy in actin filaments increased as cells spread out, while the energy stored in microtubules increased at initial spreading, peaked in middle phase, and then

  9. Distribution of T Cells in Rainbow Trout (Oncorhynchus mykiss) Skin and Responsiveness to Viral Infection

    Science.gov (United States)

    Leal, Esther; Granja, Aitor G.; Zarza, Carlos; Tafalla, Carolina

    2016-01-01

    Although the skin constitutes the first line of defense against waterborne pathogens, there is a great lack of information regarding the skin associated lymphoid tissue (SALT) and whether immune components of the skin are homogeneously distributed through the surface of the fish is still unknown. In the current work, we have analyzed the transcription of several immune genes throughout different rainbow trout (Oncorhynchus mykiss) skin areas. We found that immunoglobulin and chemokine gene transcription levels were higher in a skin area close to the gills. Furthermore, this skin area as well as other anterior sections also transcribed significantly higher levels of many different immune genes related to T cell immunity such as T cell receptor α (TCRα), TCRγ, CD3, CD4, CD8, perforin, GATA3, Tbet, FoxP3, interferon γ (IFNγ), CD40L and Eomes in comparison to posterior skin sections. In agreement with these results, immunohistochemical analysis revealed that anterior skin areas had a higher concentration of CD3+ T cells and flow cytometry analysis confirmed that the percentage of CD8+ T lymphocytes was also higher in anterior skin sections. These results demonstrate for the first time that T cells are not homogeneously distributed throughout the teleost skin. Additionally, we studied the transcriptional regulation of these and additional T cell markers in response to a bath infection with viral hemorrhagic septicemia virus (VHSV). We found that VHSV regulated the transcription of several of these T cell markers in both the skin and the spleen; with some differences between anterior and posterior skin sections. Altogether, our results point to skin T cells as major players of teleost skin immunity in response to waterborne viral infections. PMID:26808410

  10. Heterogeneity of DNA Distribution in Diploid Cells: A New Predicitive Discriminant Factor for Solid Tumour Behaviour

    Directory of Open Access Journals (Sweden)

    Jacques Assailly

    1999-01-01

    Full Text Available Spatial nuclear DNA heterogeneity distribution of Feulgen‐stained DNA diploid cells was studied by image cytometry in voided urine of 119 patients without bladder tumour (n=20 and with initial (n=23 or previous (n=76 diagnosed bladder tumour. For each patient, repetitive DNA measurements were performed during 1–4 years of follow up. Only cells of diploid DNA histograms and diploid subpopulations of aneuploid DNA histograms were used for analysis. DNA heterogeneity distribution of these diploid cells was quantified by statistical parameters of each nuclear optical density distribution. Discriminant analysis was performed on three groups of DNA histograms. Group A (n=44: aneuploid DNA histograms of patients with bladder tumour. Group D (n=55: 38 diploid DNA histograms of the 20 patients without bladder tumour (subgroup D1 and 17 diploid DNA histograms of patients with a non‐recurrent bladder tumour (subgroup D2. Group R (n=27: diploid DNA histograms of patients with bladder tumour recurrence. No statistically significant discriminant function was found to separate D1 and D2. However, the first canonical discriminant function C1 differentiated diploid cells of diploid DNA histograms (group D and group R from diploid cell subpopulations of aneuploid DNA histograms (group A. Mean C1 values were 1.06, 0.84 and –1.45 for groups R, D and A, respectively. The second canonical discriminant function C2 differentiated diploid DNA histograms of patients with bladder tumour recurrence (group R from diploid DNA histograms of patients without bladder tumour or without bladder tumour recurrence (group D. Mean C2 values were 1.78 and –0.76 for groups R and D, respectively. In 95% confidence limit, the rate of rediscrimination using the two first canonical discriminant functions C1 and C2 were 86.4, 74.5 and 74.1% for groups A, D and R, respectively. Percent of “grouped” cases correctly classified was 78.6%. Thus spatial DNA heterogeneity

  11. Finite-width plasmonic waveguides with hyperbolic multilayer cladding.

    Science.gov (United States)

    Babicheva, Viktoriia E; Shalaginov, Mikhail Y; Ishii, Satoshi; Boltasseva, Alexandra; Kildishev, Alexander V

    2015-04-20

    Engineering plasmonic metamaterials with anisotropic optical dispersion enables us to tailor the properties of metamaterial-based waveguides. We investigate plasmonic waveguides with dielectric cores and multilayer metal-dielectric claddings with hyperbolic dispersion. Without using any homogenization, we calculate the resonant eigenmodes of the finite-width cladding layers, and find agreement with the resonant features in the dispersion of the cladded waveguides. We show that at the resonant widths, the propagating modes of the waveguides are coupled to the cladding eigenmodes and hence, are strongly absorbed. By avoiding the resonant widths in the design of the actual waveguides, the strong absorption can be eliminated.

  12. Nightside studies of coherent HF Radar spectral width behaviour

    Directory of Open Access Journals (Sweden)

    E. E. Woodfield

    Full Text Available A previous case study found a relationship between high spectral width measured by the CUTLASS Finland HF radar and elevated electron temperatures observed by the EISCAT and ESR incoherent scatter radars in the post-midnight sector of magnetic local time. This paper expands that work by briefly re-examining that interval and looking in depth at two further case studies. In all three cases a region of high HF spectral width (>200 ms-1 exists poleward of a region of low HF spectral width (<200 ms-1. Each case, however, occurs under quite different geomagnetic conditions. The original case study occurred during an interval with no observed electrojet activity, the second study during a transition from quiet to active conditions with a clear band of ion frictional heating indicating the location of the flow reversal boundary, and the third during an isolated sub-storm. These case studies indicate that the relationship between elevated electron temperature and high HF radar spectral width appears on closed field lines after 03:00 magnetic local time (MLT on the nightside. It is not clear whether the same relationship would hold on open field lines, since our analysis of this relationship is restricted in latitude. We find two important properties of high spectral width data on the nightside. Firstly the high spectral width values occur on both open and closed field lines, and secondly that the power spectra which exhibit high widths are both single-peak and multiple-peak. In general the regions of high spectral width (>200 ms-1 have more multiple-peak spectra than the regions of low spectral widths whilst still maintaining a majority of single-peak spectra. We also find that the region of ion frictional heating is collocated with many multiple-peak HF spectra. Several mechanisms for the generation of high spectral width have been proposed which would produce multiple-peak spectra, these are discussed in relation to

  13. The effect of buffer zone width on biodiversity

    DEFF Research Database (Denmark)

    Navntoft, Søren; Sigsgaard, Lene; Kristensen, Kristian

    2012-01-01

    Field margin management for conservation purposes is a way to protect both functional biodiversity and biodiversity per se without considerable economical loss as field margins are less productive. However, the effect of width of the buffer zone on achievable biodiversity gains has received little...... attention in previous studies. In this paper we report on finding for syrphids, spiders and carabids, three taxonomic groups with different mobility, all important for conservation biological control. For all groups we found an effect of buffer zone width on their density. A buffer width of 6m...

  14. Biologic width and crown lengthening: case reports and review.

    Science.gov (United States)

    Oh, Se-Lim

    2010-01-01

    The biologic width includes both the connective tissue attachment and the junctional epithelium and has a mean dimension of approximately 2 mm. Invading the biologic width with a restoration can result in localized crestal bone loss, gingival recession, localized gingival hyperplasia, or a combination of these three. When restoring teeth that have subgingival caries or fractures below the gingival attachment, a clinical crown-lengthening procedure is needed to establish the biologic width. This article presents three case reports that utilized crown-lengthening procedures.

  15. Distribution of obestatin and ghrelin in human tissues: immunoreactive cells in the gastrointestinal tract, pancreas, and mammary glands

    DEFF Research Database (Denmark)

    Grönberg, Malin; Tsolakis, Apostolos V; Magnusson, Linda

    2008-01-01

    Obestatin and ghrelin are two peptides derived from the same prohormone. It is well established that ghrelin is produced by endocrine cells in the gastric mucosa. However, the distribution of human obestatin immunoreactive cells is not thoroughly characterized. A polyclonal antibody...... that specifically recognizes human obestatin was produced. Using this antibody and a commercial antibody vs ghrelin, the distribution of obestatin and ghrelin immunoreactive cells was determined in a panel of human tissues using immunohistochemistry. The two peptides were detected in the mucosa...

  16. Data on Neutron Widths do not refute Random--Matrix Theory

    CERN Document Server

    Shriner, J F; Mitchell, G E

    2012-01-01

    Recent analyses of the distribution of reduced neutron widths in the Nuclear Data Ensemble (NDE) and in the Pt isotopes claim strong disagreement with predictions of random--matrix theory. Using numerical simulations we identify the causes for the apparent disagreement. For the NDE it is a strong bias inherent in the method of analysis. In the Pt isotopes, it is likely to be a threshold state.

  17. X-ray microimaging of cisplatin distribution in ovarian cancer cells

    Science.gov (United States)

    Kiyozuka, Yasuhiko; Takemoto, Kuniko; Yamamoto, Akitsugu; Guttmann, Peter; Tsubura, Airo; Kihara, Hiroshi

    2000-05-01

    X-ray microscopy has the possibility to be in use for elemental analysis of tissue and cells especially under physiological conditions with high lateral resolution. In X-ray microimaging cisdiamminedichloroplatinum II (cisplatin: CDDP), an anticancer agent, which has a platinum atom at its functional center gives sufficient contrast against organic material at sub-cellular level. We analyzed the enhance effect and intracellular distribution of CDDP in human ovarian cancer cells with the transmission X-ray microscope at BESSY, Berlin. Two human ovarian cancer cell lines (MN-1 and EC) were treated with 1 and 10 μg/ml of CDDP for 4 hours and compared with untreated cells X-ray images of CDDP-treated samples show clearly labeled nucleoli, periphery of the nucleus and mitochondria, in a concentration-dependent manner. CDDP binds to DNA molecules via the formation of intra- or-inter-strand cross-links. Higher contrasts at the periphery of nucleus and nucleoli suggest the distribution of tightly packed heterochromatin. In addition, results show the possibility that CDDP binds to mitochondrial DNA. Biological function of cisplatin is not only the inhibition of DNA replication but is suggested to disturb mitochondrial function and RNA synthesis in the nucleolus.

  18. Altered subcellular distribution of nucleolar protein fibrillarin by actinomycin D in Hep-2 cells

    Institute of Scientific and Technical Information of China (English)

    Min CHEN; Ping JIANG

    2004-01-01

    AIM: To study the effects of actinomycin D on subcellular distribution of nucleolar protein fibrillarin in HEp-2(human esophageal epithelial type 2) cells, and molecular mechanisms for maintenance of fibrillarin in nucleolus.METHODS: Indirect immunofiuorescence assay was employed to investigate subcellular distribution of nucleolar protein fibrillarin and immunoblotting analysis was used to detect the total cellular amount of fibrillarin. RESULTS:Control cells with no drug treatment showed bright clumpy nucleolar staining, which indicated that fibrillarin decorated the nucleolus only. Treatment with actinomycin D caused dislocation of fibrillarin from nucleoli to nucleoplasm with numerous stained small nucleoplasmic entities. Immunoblotting showed that neither total cellular amount of fibrillarin nor the integrity of fibrillarin was changed upon the treatment. The dislocation of fibrillarin in cells treated at a lower concentration (0.05 mg/L) of actinomycin D, was totally reversible after removal of the drug from the medium. However, this reversion was not observed at a high drug concentration (1 mg/L). CONCLUSION:Actinomycin D induced dislocation of fibrillarin from nucleoli to nucleoplasm in HEp-2 cells. The retention of fibrillarin within the nucleolus was related to active RNA synthesis.

  19. Chronic ketamine produces altered distribution of parvalbumin-positive cells in the hippocampus of adult rats.

    Science.gov (United States)

    Sabbagh, Jonathan J; Murtishaw, Andrew S; Bolton, Monica M; Heaney, Chelcie F; Langhardt, Michael; Kinney, Jefferson W

    2013-08-29

    The underlying mechanisms of schizophrenia pathogenesis are not well understood. Increasing evidence supports the glutamatergic hypothesis that posits a hypofunction of the N-methyl D-aspartate (NMDA) receptor on specific gamma amino-butyric acid (GABA)-ergic neurons may be responsible for the disorder. Alterations in the GABAergic system have been observed in schizophrenia, most notably a change in the expression of parvalbumin (PV) in the cortex and hippocampus. Several reports also suggest abnormal neuronal migration may play a role in the etiology of schizophrenia. The current study examined the positioning and distribution of PV-positive cells in the hippocampus following chronic treatment with the NMDA receptor antagonist ketamine. A robust increase was found in the number of PV-positive interneurons located outside the stratum oriens (SO), the layer where most of these cells are normally localized, as well as an overall numerical increase in CA3 PV cells. These results suggest ketamine leads to an abnormal distribution of PV-positive cells, which may be indicative of aberrant migratory activity and possibly related to the Morris water maze deficits observed. These findings may also be relevant to alterations observed in schizophrenia populations.

  20. Climatology Applied To Architecture: An Experimental Investigation about Internal Temperatures Distribution at Two Test Cells

    Directory of Open Access Journals (Sweden)

    Grace Tibério Cardoso

    2016-04-01

    Full Text Available Data were analyzed en relative spatial distribution of the internal surface temperature (IST and internal air temperature or dry bulb (TBS, in two different test cells, for a typical experimental day under the influence of tropical mass. The main goal of this research is to provide guidelines to collect temperature data experimentally since there is not an appropriate standard to guide this methodological procedure in buildings. The data series of dry bulb temperature and internal surface temperatures were measured in a test cell with a green roof and the other with conventional ceramic roof by thermocouples installed at predetermined locations. The data of solar radiation and the main climatic variables were recorded by the automatic weather station at the Center of Science Engineering Applied to the Environment (CCEAMA, School of Engineering of São Carlos (EESC-USP. The results led to the conclusion that the distribution of the internal surface temperature is almost uniform in the two test cells, but in relation to the dry bulb temperature there is a small vertical temperature gradient in the conventional cell. This work will contribute significantly to future studies in the area of human comfort and environmental suitability of buildings

  1. Current Density Distribution Mapping in PEM Fuel Cells as An Instrument for Operational Measurements

    Directory of Open Access Journals (Sweden)

    Martin Geske

    2010-04-01

    Full Text Available A newly developed measurement system for current density distribution mapping has enabled a new approach for operational measurements in proton exchange membrane fuel cells (PEMFC. Taking into account previously constructed measurement systems, a method based on a multi layer printed circuit board was chosen for the development of the new system. This type of system consists of a sensor, a special electronic device and the control and visualization PC. For the acquisition of the current density distribution values, a sensor device was designed and installed within a multilayer printed circuit board with integrated shunt resistors. Varying shunt values can be taken into consideration with a newly developed and evaluated calibration method. The sensor device was integrated in a PEM fuel cell stack to prove the functionality of the whole measurement system. A software application was implemented to visualize and save the measurement values. Its functionality was verified by operational measurements within a PEMFC system. Measurement accuracy and possible negative reactions of the sensor device during PEMFC operation are discussed in detail in this paper. The developed system enables operational measurements for different operating phases of PEM fuel cells. Additionally, this can be seen as a basis for new opportunities of optimization for fuel cell design and operation modes.

  2. Quantitative analysis of organelle distribution and dynamics in Physcomitrella patens protonemal cells

    Directory of Open Access Journals (Sweden)

    Furt Fabienne

    2012-05-01

    Full Text Available Abstract Background In the last decade, the moss Physcomitrella patens has emerged as a powerful plant model system, amenable for genetic manipulations not possible in any other plant. This moss is particularly well suited for plant polarized cell growth studies, as in its protonemal phase, expansion is restricted to the tip of its cells. Based on pollen tube and root hair studies, it is well known that tip growth requires active secretion and high polarization of the cellular components. However, such information is still missing in Physcomitrella patens. To gain insight into the mechanisms underlying the participation of organelle organization in tip growth, it is essential to determine the distribution and the dynamics of the organelles in moss cells. Results We used fluorescent protein fusions to visualize and track Golgi dictyosomes, mitochondria, and peroxisomes in live protonemal cells. We also visualized and tracked chloroplasts based on chlorophyll auto-fluorescence. We showed that in protonemata all four organelles are distributed in a gradient from the tip of the apical cell to the base of the sub-apical cell. For example, the density of Golgi dictyosomes is 4.7 and 3.4 times higher at the tip than at the base in caulonemata and chloronemata respectively. While Golgi stacks are concentrated at the extreme tip of the caulonemata, chloroplasts and peroxisomes are totally excluded. Interestingly, caulonemata, which grow faster than chloronemata, also contain significantly more Golgi dictyosomes and fewer chloroplasts than chloronemata. Moreover, the motility analysis revealed that organelles in protonemata move with low persistency and average instantaneous speeds ranging from 29 to 75 nm/s, which are at least three orders of magnitude slower than those of pollen tube or root hair organelles. Conclusions To our knowledge, this study reports the first quantitative analysis of organelles in Physcomitrella patens and will make possible

  3. Assessing T cell clonal size distribution: a non-parametric approach.

    Science.gov (United States)

    Bolkhovskaya, Olesya V; Zorin, Daniil Yu; Ivanchenko, Mikhail V

    2014-01-01

    Clonal structure of the human peripheral T-cell repertoire is shaped by a number of homeostatic mechanisms, including antigen presentation, cytokine and cell regulation. Its accurate tuning leads to a remarkable ability to combat pathogens in all their variety, while systemic failures may lead to severe consequences like autoimmune diseases. Here we develop and make use of a non-parametric statistical approach to assess T cell clonal size distributions from recent next generation sequencing data. For 41 healthy individuals and a patient with ankylosing spondylitis, who undergone treatment, we invariably find power law scaling over several decades and for the first time calculate quantitatively meaningful values of decay exponent. It has proved to be much the same among healthy donors, significantly different for an autoimmune patient before the therapy, and converging towards a typical value afterwards. We discuss implications of the findings for theoretical understanding and mathematical modeling of adaptive immunity.

  4. Assessing T cell clonal size distribution: a non-parametric approach.

    Directory of Open Access Journals (Sweden)

    Olesya V Bolkhovskaya

    Full Text Available Clonal structure of the human peripheral T-cell repertoire is shaped by a number of homeostatic mechanisms, including antigen presentation, cytokine and cell regulation. Its accurate tuning leads to a remarkable ability to combat pathogens in all their variety, while systemic failures may lead to severe consequences like autoimmune diseases. Here we develop and make use of a non-parametric statistical approach to assess T cell clonal size distributions from recent next generation sequencing data. For 41 healthy individuals and a patient with ankylosing spondylitis, who undergone treatment, we invariably find power law scaling over several decades and for the first time calculate quantitatively meaningful values of decay exponent. It has proved to be much the same among healthy donors, significantly different for an autoimmune patient before the therapy, and converging towards a typical value afterwards. We discuss implications of the findings for theoretical understanding and mathematical modeling of adaptive immunity.

  5. Live-cell and super-resolution imaging reveal that the distribution of wall-associated protein A is correlated with the cell chain integrity of Streptococcus mutans.

    Science.gov (United States)

    Li, Y; Liu, Z; Zhang, Y; Su, Q P; Xue, B; Shao, S; Zhu, Y; Xu, X; Wei, S; Sun, Y

    2015-10-01

    Streptococcus mutans is a primary pathogen responsible for dental caries. It has an outstanding ability to form biofilm, which is vital for virulence. Previous studies have shown that knockout of Wall-associated protein A (WapA) affects cell chain and biofilm formation of S. mutans. As a surface protein, the distribution of WapA remains unknown, but it is important to understand the mechanism underlying the function of WapA. This study applied the fluorescence protein mCherry as a reporter gene to characterize the dynamic distribution of WapA in S. mutans via time-lapse and super-resolution fluorescence imaging. The results revealed interesting subcellular distribution patterns of WapA in single, dividing and long chains of S. mutans cells. It appears at the middle of the cell and moves to the poles as the cell grows and divides. In a cell chain, after each round of cell division, such dynamic relocation results in WapA distribution at the previous cell division sites, resulting in a pattern where WapA is located at the boundary of two adjacent cell pairs. This WapA distribution pattern corresponds to the breaking segmentation of wapA deletion cell chains. The dynamic relocation of WapA through the cell cycle increases our understanding of the mechanism of WapA in maintaining cell chain integrity and biofilm formation.

  6. On spatial distribution of proton radiation belt from solar cell degradation of Akebono satellite

    Science.gov (United States)

    Miyake, W.; Miyoshi, Y.; Matsuoka, A.

    2013-12-01

    Solar cells on any satellite degrade gradually due to severe space radiation environment. We found a fair correlation between the decrease rate of solar cell output current of Akebono satellite orbiting in the inner magnetosphere and trapped proton flux from AP8 model between 1989 and 1992. After 1993, presumably as a result of long-term degradation, variation of solar cell output seems more susceptible to other causes such as high temperature effect, and simple monthly averaged data show no significant relation between them. One of possible causes for the temperature variation of the solar cells is terrestrial heat radiation with changing orientation of solar cell panels towards the earth and another is solar radiation varied with eccentric earth's orbit around the sun. In order to remove the possible temperature effect, we sort the data expected to be least affected by the terrestrial heat radiation from the orbit conditions, and also analyze difference of the output current for a month from that for the same month in the previous year. The analysis method leads us to successfully track a continuous correlation between the decease rate of solar cell output and energetic trapped proton flux up to 1996. We also discuss the best-fitted spatial distribution of energetic protons from comparison with model calculations.

  7. Extracting the temperature distribution on a phase-change memory cell during crystallization

    Science.gov (United States)

    Bakan, Gokhan; Gerislioglu, Burak; Dirisaglik, Faruk; Jurado, Zoila; Sullivan, Lindsay; Dana, Aykutlu; Lam, Chung; Gokirmak, Ali; Silva, Helena

    2016-10-01

    Phase-change memory (PCM) devices are enabled by amorphization- and crystallization-induced changes in the devices' electrical resistances. Amorphization is achieved by melting and quenching the active volume using short duration electrical pulses (˜ns). The crystallization (set) pulse duration, however, is much longer and depends on the cell temperature reached during the pulse. Hence, the temperature-dependent crystallization process of the phase-change materials at the device level has to be well characterized to achieve fast PCM operations. A main challenge is determining the cell temperature during crystallization. Here, we report extraction of the temperature distribution on a lateral PCM cell during a set pulse using measured voltage-current characteristics and thermal modelling. The effect of the thermal properties of materials on the extracted cell temperature is also studied, and a better cell design is proposed for more accurate temperature extraction. The demonstrated study provides promising results for characterization of the temperature-dependent crystallization process within a cell.

  8. Isolation of dihydrocurcuminoids from cell clumps and their distribution in various parts of turmeric (Curcuma longa).

    Science.gov (United States)

    Kita, Tomoko; Imai, Shinsuke; Sawada, Hiroshi; Seto, Haruo

    2009-05-01

    In addition to well-known curcuminoids, three colored metabolites were isolated from cultured cell clumps that had been induced from buds on turmeric rhizomes. The isolated compounds were identified as dihydro derivatives of curcuminoids, dihydrocurcumin (dihydroCurc), dihydrodesmethoxycurcumin-a (dihydroDMC-a), and dihydrobisdesmethoxycurcumin (dihydroBDMC). The cell clumps did not contain dihydroDMC-b, an isomer of dihydroDMC-a. A comparison of the distribution profiles of curcuminoids and dihydrocurcuminoids in the cell clumps with those in the rhizomes, leaves, and roots revealed the following differences: Unlike rhizomes, the cell clumps, leaves, and roots contained dihydrocurcuminoids as the major colored constituents. Whereas dimethoxy compounds, curcumin and dihydrocurcumin, respectively, were most abundant in the rhizomes and leaves, one of the monomethoxy derivatives, dihydroDMC-a, was found most abundantly in the cell clumps and roots. While both dihydroDMC-a and b were detected in the rhizomes, dihydroDMC-b was not detectable in the cell clumps, leaves, or roots. The occurrence of only one of the two possible isomers of dihydroDMC suggests biosynthetic formation of dihydrocurcuminoids in turmeric.

  9. Optical waveguide device with an adiabatically-varying width

    Science.gov (United States)

    Watts; Michael R. , Nielson; Gregory N.

    2011-05-10

    Optical waveguide devices are disclosed which utilize an optical waveguide having a waveguide bend therein with a width that varies adiabatically between a minimum value and a maximum value of the width. One or more connecting members can be attached to the waveguide bend near the maximum value of the width thereof to support the waveguide bend or to supply electrical power to an impurity-doped region located within the waveguide bend near the maximum value of the width. The impurity-doped region can form an electrical heater or a semiconductor junction which can be activated with a voltage to provide a variable optical path length in the optical waveguide. The optical waveguide devices can be used to form a tunable interferometer (e.g. a Mach-Zehnder interferometer) which can be used for optical modulation or switching. The optical waveguide devices can also be used to form an optical delay line.

  10. Sweep Width Estimation for Ground Search and Rescue

    Science.gov (United States)

    2004-12-30

    that may influence sweep width were measured during the experiments. Promising variables include SAR background, height, age, color - blindness , fatigue...123 8.3.9 Color Blindness ................................................................................................... 124... Color Blindness ................................................................................................ 200 Searcher Profile

  11. Widths of some classes of convex functions and bodies

    Science.gov (United States)

    Konovalov, V. N.; Maiorov, Vitalii E.

    2010-02-01

    We consider classes of uniformly bounded convex functions defined on convex compact bodies in \\mathbb{R}^d and satisfying a Lipschitz condition and establish the exact orders of their Kolmogorov, entropy, and pseudo-dimension widths in the L_1-metric. We also introduce the notions of pseudo-dimension and pseudo-dimension widths for classes of sets and determine the exact orders of the entropy and pseudo-dimension widths of some classes of convex bodies in \\mathbb{R}^drelative to the pseudo-metric defined as the d-dimensional Lebesgue volume of the symmetric difference of two sets. We also find the exact orders of the entropy and pseudo-dimension widths of the corresponding classes of characteristic functions in L_p-spaces, 1\\le p\\le\\infty.

  12. A1 demonstrates restricted tissue distribution during embryonic development and functions to protect against cell death.

    Science.gov (United States)

    Carrió, R.; López-Hoyos, M.; Jimeno, J.; Benedict, M. A.; Merino, R.; Benito, A.; Fernández-Luna, J. L.; Núñez, G.; García-Porrero, J. A.; Merino, J.

    1996-01-01

    Members of the bcl-2 gene family are essential regulators of cell survival in a wide range of biological processes. A1, a member of the family, is known to be expressed in certain adult tissues. However, the precise tissue distribution and function of A1 remains poorly understood. We show here that A1 is expressed in multiple tissues during murine embryonic development. In the embryo, A1 was detected first at embryonic day 11.5 in liver, brain, and limbs. At day 13.5 of gestation, A1 expression was observed in the central nervous system, liver, perichondrium, and digital zones of developing limbs in a pattern different from that of bcl-X. In the central nervous system of 15.5-day embryos, A1 was expressed at high levels in the ventricular zone and cortical plate of brain cortex. Significantly, the interdigital zones of limbs and the intermediate region of the developing brain cortex, two sites associated with extensive cell death, were devoid of A1 and bcl-X. The expression of A1 was retained in many adult tissues. To assess the ability of A1 to modulate cell death, stable transfectants expressing different amounts of A1 protein were generated in K562 cells. Expression of A1 was associated with retardation of apoptotic cell death induced by actinomycin D and cycloheximide as well as by okadaic acid. Confocal microscopy showed that the A1 protein was localized to the cytoplasm in a pattern similar to that of Bcl-2. These results demonstrate that the expression of A1 is wider than previously reported in adult tissues. Furthermore, its distribution in multiple tissues of the embryo suggests that A1 plays a role in the regulation of physiological cell death during embryonic development. Images Figure 1 Figure 2 Figure 3 Figure 5 PMID:8952545

  13. [Distribution of abnormal cell clone with deletion of chromosome 20q in marrow cell lineages and apoptosis cells in myelodysplastic syndrome].

    Science.gov (United States)

    Qin, Ling; Wang, Chun; Qin, You-Wen; Xie, Kuang-Cheng; Yan, Shi-Ke; Gao, Yan-Rong; Wang, Xiao-Rui; Zhao, Chu-Xian

    2008-06-01

    This study was aimed to investigate the distribution of abnormal clone in marrow cell lineages and apoptosis cells in myelodysplastic syndrome (MDS) with deletion of chromosome 20q. Monoclonal antibodies recognizing myeloid precursors (CD15), erythroid precursors (GPA), T cells (CD3(+)CD56(-)CD16(-)), B cells (CD19), NK cells (CD3(-)CD56(+)CD16(+)) were used to sort bone marrow cells in a MDS patient with del (20q) by fluorescence activated cell sorting (FACS). Annexin V-FITC and PI were used to sort bone marrow Annexin V(+)PI(-) and Annexin V(-)PI(-) cells by FACS. The sorted positive cells were detected by interphase dual-color fluorescence in situ hybridization (D-FISH) using a LSI D20S108 probe (Spectrum Orange) and a Telvysion TM 20p probe (Spectrum Green). FACS and FISH analysis were also performed on the samples from 4 cases with normal karyotype. The results showed that the proportions of MDS clone in the myeloid and erythroid precursors were 70.50% and 93.33% respectively, in the RAEB-1 patient with del (20q) and were obviously higher than that in control group (5.39% and 6.17%). The proportions of abnormal clone in T, B and NK cells were 3.23%, 4.32% and 5.77% respectively and were less than that in control group (5.76%, 4.85%, 6.36%). The percentage of apoptotic cells in the bone marrow nucleated cells was 16.09%. The proportions of MDS clone in Annexin V(+)PI(-) and Annexin V(-)PI(-) cells were 32.48% and 70.11%, respectively. It is concluded that most myeloid and erythroid precursors are originated from the abnormal clone in MDS with del (20q). A little part of apoptotic cells are derived from the abnormal clone.

  14. Quasi monolithic silicon load cell for loads up to 1000 kg with insensitivity to non-homogeneous load distributions

    NARCIS (Netherlands)

    Wiegerink, Remco; Zwijze, Robert; Krijnen, Gijs; Lammerink, Theo; Elwenspoek, Miko

    2000-01-01

    In this paper, a micromachined silicon load cell (force sensor) is presented for measuring loads up to 1000 kg. The sensitive surface of 1 cm2 contains a matrix of capacitive sensing elements to make the load cell insensitive to non-homogeneous load distributions. The load cell has been realized and

  15. A practical eco-environmental distribution network planning model including fuel cells and non-renewable distributed energy resources

    Energy Technology Data Exchange (ETDEWEB)

    Soroudi, Alireza [Department of Electrical Engineering, Sharif University of Technology, Tehran (Iran); Ehsan, Mehdi [Department of Electrical Engineering, Sharif University of Technology, Tehran (Iran); Center of Excellence in Power System Management and Control, Sharif University of Technology, Tehran (Iran); Zareipour, Hamidreza [Department of Electrical and Computer Engineering, University of Calgary, Alberta (Canada)

    2011-01-15

    This paper presents a long-term dynamic multi-objective planning model for distribution network expansion along with distributed energy options. The proposed model optimizes two objectives, namely costs and emissions and determines the optimal schemes of sizing, placement and specially the dynamics (i.e., timing) of investments on distributed generation units and network reinforcements over the planning period. An efficient two-stage heuristic method is proposed to solve the formulated planning problem. The effectiveness of the proposed model is demonstrated by applying it to a distribution network and comparing the simulation results with other methods and models. (author)

  16. Estimating the Spectral Width of a Narrowband Optical Signal

    DEFF Research Database (Denmark)

    Lading, Lars; Skov Jensen, A.

    1980-01-01

    Methods for estimating the spectral width of a narrowband optical signal are investigated. Spectral analysis and Fourier spectroscopy are compared. Optimum and close-to-optimum estimators are developed under the constraint of having only one photodetector.......Methods for estimating the spectral width of a narrowband optical signal are investigated. Spectral analysis and Fourier spectroscopy are compared. Optimum and close-to-optimum estimators are developed under the constraint of having only one photodetector....

  17. Calculating Method of Moments Uniform Bin Width Histograms

    OpenAIRE

    James S. Weber

    2016-01-01

    A clear articulation of Method of Moments (MOM) Histograms is instructive and has waited 121 years since 1895. Also of interest are enabling uniform bin width (UBW) shape level sets. Mean-variance MOM uniform bin width frequency and density histograms are not unique, however ranking them by histogram skewness compared to data skewness helps. Although theoretical issues rarely take second place to calculations, here calculations based on shape level sets are central and challenge uncritically ...

  18. Energetic Constraints on the Width of the Intertropical Convergence Zone

    OpenAIRE

    2016-01-01

    The intertropical convergence zone (ITCZ) has been the focus of considerable research in recent years, with much of this work concerned with how the latitude of maximum tropical precipitation responds to natural climate variability and to radiative forcing. The width of the ITCZ, however, has received little attention despite its importance for regional climate and for understanding the general circulation of the atmosphere. This paper investigates the ITCZ width in simulations with an ideali...

  19. Experimental Study on Surface Dielectric Barrier Discharge Plasma Actuator with Different Encapsulated Electrode Widths for Airflow Control at Atmospheric Pressure

    Science.gov (United States)

    Qi, Xiaohua; Yang, Liang; Yan, Huijie; Jin, Ying; Hua, Yue; Ren, Chunsheng

    2016-10-01

    The surface dielectric barrier discharge (SDBD) plasma actuator has shown great promise as an aerodynamic flow control device. In this paper, the encapsulated electrode width of a SDBD actuator is changed to study the airflow acceleration behavior. The effects of encapsulated electrode width on the actuator performance are experimentally investigated by measuring the dielectric layer surface potential, time-averaged ionic wind velocity and thrust force. Experimental results show that the airflow velocity and thrust force increase with the encapsulated electrode width. The results can be attributed to the distinct plasma distribution at different encapsulated electrode widths. supported by National Natural Science Foundation of China (No. 11175037), National Natural Science Foundation for Young Scientists of China (No. 11305017) and Special Fund for Theoretical Physics (No. 11247239)

  20. Width dependent transition of quantized spin-wave modes in Ni{sub 80}Fe{sub 20} square nanorings

    Energy Technology Data Exchange (ETDEWEB)

    Banerjee, Chandrima; Saha, Susmita; Barman, Saswati; Barman, Anjan, E-mail: abarman@bose.res.in [Thematic Unit of Excellence on Nanodevice Technology, Department of Condensed Matter Physics and Material Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700098 (India); Rousseau, Olivier [CEMS-RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Otani, YoshiChika [CEMS-RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Institute for Solid State Physics, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8581 (Japan)

    2014-10-28

    We investigated optically induced ultrafast magnetization dynamics in square shaped Ni{sub 80}Fe{sub 20} nanorings with varying ring width. Rich spin-wave spectra are observed whose frequencies showed a strong dependence on the ring width. Micromagnetic simulations showed different types of spin-wave modes, which are quantized upto very high quantization number. In the case of widest ring, the spin-wave mode spectrum shows quantized modes along the applied field direction, which is similar to the mode spectrum of an antidot array. As the ring width decreases, additional quantization in the azimuthal direction appears causing mixed modes. In the narrowest ring, the spin-waves exhibit quantization solely in azimuthal direction. The different quantization is attributed to the variation in the internal field distribution for different ring width as obtained from micromagnetic analysis and supported by magnetic force microscopy.

  1. Enhanced biofilm distribution and cell performance of microfluidic microbial fuel cells with multiple anolyte inlets.

    Science.gov (United States)

    Yang, Yang; Ye, Dingding; Liao, Qiang; Zhang, Pengqing; Zhu, Xun; Li, Jun; Fu, Qian

    2016-05-15

    A laminar-flow controlled microfluidic microbial fuel cell (MMFC) is considered as a promising approach to be a bio-electrochemical system (BES). But poor bacterial colonization and low power generation are two severe bottlenecks to restrict its development. In this study, we reported a MMFC with multiple anolyte inlets (MMFC-MI) to enhance the biofilm formation and promote the power density of MMFCs. Voltage profiles during the inoculation process demonstrated MMFC-MI had a faster start-up process than the conventional microfluidic microbial fuel cell with one inlet (MMFC-OI). Meanwhile, benefited from the periodical replenishment of boundary layer near the electrode, a more densely-packed bacterial aggregation was observed along the flow direction and also the substantially low internal resistance for MMFC-MI. Most importantly, the output power density of MMFC-MI was the highest value among the reported µl-scale MFCs to our best knowledge. The presented MMFC-MI appears promising for bio-chip technology and extends the scope of microfluidic energy.

  2. Geometric methods for estimating representative sidewalk widths applied to Vienna's streetscape surfaces database

    Science.gov (United States)

    Brezina, Tadej; Graser, Anita; Leth, Ulrich

    2017-04-01

    Space, and in particular public space for movement and leisure, is a valuable and scarce resource, especially in today's growing urban centres. The distribution and absolute amount of urban space—especially the provision of sufficient pedestrian areas, such as sidewalks—is considered crucial for shaping living and mobility options as well as transport choices. Ubiquitous urban data collection and today's IT capabilities offer new possibilities for providing a relation-preserving overview and for keeping track of infrastructure changes. This paper presents three novel methods for estimating representative sidewalk widths and applies them to the official Viennese streetscape surface database. The first two methods use individual pedestrian area polygons and their geometrical representations of minimum circumscribing and maximum inscribing circles to derive a representative width of these individual surfaces. The third method utilizes aggregated pedestrian areas within the buffered street axis and results in a representative width for the corresponding road axis segment. Results are displayed as city-wide means in a 500 by 500 m grid and spatial autocorrelation based on Moran's I is studied. We also compare the results between methods as well as to previous research, existing databases and guideline requirements on sidewalk widths. Finally, we discuss possible applications of these methods for monitoring and regression analysis and suggest future methodological improvements for increased accuracy.

  3. Geometric methods for estimating representative sidewalk widths applied to Vienna's streetscape surfaces database

    Science.gov (United States)

    Brezina, Tadej; Graser, Anita; Leth, Ulrich

    2017-02-01

    Space, and in particular public space for movement and leisure, is a valuable and scarce resource, especially in today's growing urban centres. The distribution and absolute amount of urban space—especially the provision of sufficient pedestrian areas, such as sidewalks—is considered crucial for shaping living and mobility options as well as transport choices. Ubiquitous urban data collection and today's IT capabilities offer new possibilities for providing a relation-preserving overview and for keeping track of infrastructure changes. This paper presents three novel methods for estimating representative sidewalk widths and applies them to the official Viennese streetscape surface database. The first two methods use individual pedestrian area polygons and their geometrical representations of minimum circumscribing and maximum inscribing circles to derive a representative width of these individual surfaces. The third method utilizes aggregated pedestrian areas within the buffered street axis and results in a representative width for the corresponding road axis segment. Results are displayed as city-wide means in a 500 by 500 m grid and spatial autocorrelation based on Moran's I is studied. We also compare the results between methods as well as to previous research, existing databases and guideline requirements on sidewalk widths. Finally, we discuss possible applications of these methods for monitoring and regression analysis and suggest future methodological improvements for increased accuracy.

  4. PIC simulations of the trapped electron filamentation instability in finite-width electron plasma waves

    Science.gov (United States)

    Winjum, B. J.; Banks, J. W.; Berger, R. L.; Cohen, B. I.; Chapman, T.; Hittinger, J. A. F.; Rozmus, W.; Strozzi, D. J.; Brunner, S.

    2012-10-01

    We present results on the kinetic filamentation of finite-width nonlinear electron plasma waves (EPW). Using 2D simulations with the PIC code BEPS, we excite a traveling EPW with a Gaussian transverse profile and a wavenumber k0λDe= 1/3. The transverse wavenumber spectrum broadens during transverse EPW localization for small width (but sufficiently large amplitude) waves, while the spectrum narrows to a dominant k as the initial EPW width increases to the plane-wave limit. For large EPW widths, filaments can grow and destroy the wave coherence before transverse localization destroys the wave; the filaments in turn evolve individually as self-focusing EPWs. Additionally, a transverse electric field develops that affects trapped electrons, and a beam-like distribution of untrapped electrons develops between filaments and on the sides of a localizing EPW. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344 and funded by the Laboratory Research and Development Program at LLNL under project tracking code 12-ERD-061. Supported also under Grants DE-FG52-09NA29552 and NSF-Phy-0904039. Simulations were performed on UCLA's Hoffman2 and NERSC's Hopper.

  5. Distribution patterns of stromal eosinophil cells in chick thymus during postnatal development.

    Science.gov (United States)

    Huang, Hai-Bo; Liu, Yin-Xue; Hou, Yong; Wen, Le; Ge, Xiao-Hong; Peng, Ke-Mei; Liu, Hua-Zhen

    2013-05-15

    Eosinophils are a type of thymic stromal cell that are present in the thymus of both humans and mice. They participate in regulating T-cell development under non-pathological conditions. However, studies are scarce regarding the role of eosinophils in the development of the thymus in chickens. Therefore, this study investigated the distribution of eosinophils in normal chicken thymi at different stages of development. Seven thymi were obtained from chickens at days 1, 21 and 35 of development. The distribution of eosinophils in the thymi was analyzed by histological and immunohistochemical techniques using Lendrum's chromotrope 2R method and an antibody against eosinophilic cationic protein (ECP), respectively. Eosinophils were constitutively located in the chick thymus. They were mainly distributed in the thymic corticomedullary junction and medulla, especially around vessels and Hassall's corpuscles, and only a few were in the trabeculae among thymic lobules and around vessels. There were none in the cortex. The number of thymic eosinophils decreased with increasing age (Pdevelopment, especially during the early stages of development.

  6. Effects of berberine on proliferation, cell cycle distribution and apoptosis of human breast cancer T47D and MCF7 cell lines

    Directory of Open Access Journals (Sweden)

    Elmira Barzegar

    2015-04-01

    Conclusion: Berberine alone and in combination with doxorubicin inhibited cell proliferation, induced apoptosis and altered cell cycle distribution of breast cancer cells. Therefore, berberine showed to be a good candidate for further studies as a new anticancer drug in the treatment of human breast cancer.

  7. Cell-laden poly(ɛ-caprolactone)/alginate hybrid scaffolds fabricated by an aerosol cross-linking process for obtaining homogeneous cell distribution: fabrication, seeding efficiency, and cell proliferation and distribution.

    Science.gov (United States)

    Lee, HyeongJin; Ahn, SeungHyun; Bonassar, Lawrence J; Chun, Wook; Kim, GeunHyung

    2013-10-01

    Generally, solid-freeform fabricated scaffolds show a controllable pore structure (pore size, porosity, pore connectivity, and permeability) and mechanical properties by using computer-aided techniques. Although the scaffolds can provide repeated and appropriate pore structures for tissue regeneration, they have a low biological activity, such as low cell-seeding efficiency and nonuniform cell density in the scaffold interior after a long culture period, due to a large pore size and completely open pores. Here we fabricated three different poly(ɛ-caprolactone) (PCL)/alginate scaffolds: (1) a rapid prototyped porous PCL scaffold coated with an alginate, (2) the same PCL scaffold coated with a mixture of alginate and cells, and (3) a multidispensed hybrid PCL/alginate scaffold embedded with cell-laden alginate struts. The three scaffolds had similar micropore structures (pore size = 430-580 μm, porosity = 62%-68%, square pore shape). Preosteoblast cells (MC3T3-E1) were used at the same cell density in each scaffold. By measuring cell-seeding efficiency, cell viability, and cell distribution after various periods of culturing, we sought to determine which scaffold was more appropriate for homogeneously regenerated tissues.

  8. Size distribution of fullerenol nanoparticles in cell culture medium and their influence on antioxidative enzymes in Chinese hamster ovary cells

    Directory of Open Access Journals (Sweden)

    Srđenović Branislava U.

    2015-01-01

    Full Text Available Fullerenol (C60(OH24 nanoparticles (FNP have a significant role in biomedical research due to their numerous biological activities, some of which are cytoprotective and antioxidative properties. The aim of this study was to measure distribution of fullerenol nanoparticles and zeta potential in cell medium RPMI 1640 with 10% fetal bovine serum (FBS and to investigate the influence of FNP on Chinese hamster ovary cells (CHO-K1 survival, as well as to determine the activity of three antioxidative enzymes: superoxide-dismutase, glutathione-reductase and glutathione-S-transferase in mitomycin C-treated cell line. Our investigation implies that FNP, as a strong antioxidant, influence the cellular redox state and enzyme activities and thus may reduce cell proliferation, which confirms that FNP could be exploited for its use as a cytoprotective agent.[Projekat Ministarstva nauke Republike Srbije, br. III45005 i Pokrajinski Sekretarijat za nauku i tehnološki razvoj Vojvodine, grant number 114-451-2056/2011-01

  9. Effect of initial salt concentrations on cell performance and distribution of internal resistance in microbial desalination cells.

    Science.gov (United States)

    Yang, Euntae; Choi, Mi-Jin; Kim, Kyoung-Yeol; Chae, Kyu-Jung; Kim, In S

    2015-01-01

    Microbial desalination cells (MDCs) are modified microbial fuel cells (MFCs) that concurrently produce electricity and desalinate seawater, but adding a desalination compartment and an ion-exchange membrane may increase the internal resistance (Ri), which can limit the cell performance. However, the effects of a desalination chamber and initial NaCl concentrations on the internal resistances and the cell performances (i.e. Coulombic efficiency (CE), current and power density) of MDCs have yet to be thoroughly explored; thus, the cell performance and Ri distributions of MDCs having different initial concentrations and an MFC having no desalination chamber were compared. In the MDCs, the current and power density generation increased from 2.82 mA and 158.2 mW/m2 to 3.17 mA and 204.5 mW/m2 when the initial NaCl concentrations were increased from 5 to 30 g/L, as a consequence of the internal resistances decreasing from 2432.0 to 2328.4 Ω. And even though the MFC has a lower Ri than the MDCs, lower cell performances (current: 2.59 mA; power density: 141.6 mW/m2 and CE: 62.1%) were observed; there was no effect of improved junction potential in the MFC. Thus, in the MDCs, the higher internal resistances due to the addition of a desalination compartment can be offset by reducing the electrolyte resistance and improving the junction potential at higher NaCl concentrations.

  10. Temporal and spatial changes in Ca2+ distribution during the programmed cell death of tracheary elements

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The changes in Ca2+ distribution in the tracheary elements (TEs) of the pepper leaves were studied using the cytochemical method of potassium antimonate. At the early stage of TEs formation, the vacuole and the nucleus held large volume, and antimonate Ca2+ deposits were observed mainly in the intercellular space and the cell wall. As the thickening of secondary wall occurred, the vacuole, nucleus and other organelles began to rupture, concomitant with the increase of calcium deposits in the cytosol, showing the influx of Ca2+ into the cell. With the further rupture of cytoplasm and other organelles, the number of calcium deposits at the non-thickening cell wall increased, but declined at the thickening bands of the secondary wall. When the cytoplasmic contents disappeared completely, the level of Ca2+ decreased at the non-thickening wall, but by contrast,increased at the thickening bands of the secondary wall.These observations indicated that the dynamic changes in Ca2+ distribution spatially and temporarily might have a close correlation with its distinct roles played during the formation of the secondary walls.

  11. The distribution of TPX2 in dividing leaf cells of the fern Asplenium nidus.

    Science.gov (United States)

    Panteris, E; Adamakis, I-D S; Chanoumidou, K

    2013-01-01

    Plant cell division requires the dynamic organisation of several microtubule arrays. The mechanisms of regulation of the above arrays are under rigorous research. Among several factors that are involved in plant microtubule dynamics, the Targeting Protein for Xklp2 (TPX2) has been found to play a role in spindle organisation, in combination with Aurora kinases, in dividing cells of angiosperms. Microtubule organisation in dividing cells of ferns exhibits certain peculiarities. Accordingly, the presence and distribution of a TPX2 homologue might be helpful in understanding the patterns and regulatory mechanisms of microtubule arrays in this plant group. In this study, a putative TPX2 homologue was identified using Western blotting in the fern Asplenium nidus. It was found, using immunostaining and CLSM, that it is co-localised with perinuclear preprophase microtubules and the prophase spindle, and follows the microtubule pattern during metaphase/anaphase and telophase. During cytokinesis, while in angiosperms TPX2 is degraded, in A. nidus the TPX2 signal persists, co-localising with the phragmoplast. In early post-cytokinetic cells, a TPX2 signal is present on the nuclear surface facing the daughter cell wall and, thereafter it is co-localised with the fern-specific microtubule aggregation that lines the new wall, which is possibly involved in cortical microtubule assembly.

  12. SpatTrack: an imaging toolbox for analysis of vesicle motility and distribution in living cells

    DEFF Research Database (Denmark)

    Lund, Frederik Wendelboe; Jensen, Marie Louise; Christensen, Tanja;

    2014-01-01

    SpatTrack, an open source, platform-independent program collecting a variety of methods for analysis of vesicle dynamics and distribution in living cells. SpatTrack performs 2D particle tracking, trajectory analysis and fitting of diffusion models to the calculated mean square displacement. It allows......The endocytic pathway is a complex network of highly dynamic organelles, which has been traditionally studied by quantitative fluorescence microscopy. The data generated by this method can be overwhelming and its analysis, even for the skilled microscopist, is tedious and error-prone. We developed...... for spatial analysis of detected vesicle patterns including calculation of the radial distribution function and particle-based colocalization. Importantly, all analysis tools are supported by Monte Carlo simulations of synthetic images. This allows the user to assess the reliability of the analysis...

  13. A fractal analysis of the spatial distribution of tumoral mast cells in lymph nodes and bone marrow.

    Science.gov (United States)

    Guidolin, Diego; Marinaccio, Christian; Tortorella, Cinzia; Ruggieri, Simona; Rizzi, Anna; Maiorano, Eugenio; Specchia, Giorgina; Ribatti, Domenico

    2015-11-15

    The spatial distribution of mast cells inside the tumor stroma has been little investigated. In this study, we have evaluated tumor mast cells distribution through the analysis of the morphological features of the spatial patterns generated by these cells, including size, shape, and architecture of the cell pattern. We have compared diffuse large B cells lymphoma (DLBCL) and systemic mastocytosis in two different anatomical localizations (lymph nodes for DLBCL and, respectively, bone marrow for mastocytosis). Results have indicated that, despite the high difference in size exhibited by the mast cells patterns in the two conditions, the spatial relationship between the mast cells forming the aggregates resulted similar, characterized by a significant tendency of the mast cells to self-organize in clusters.

  14. Peripheral T-cell lymphoma: Frequency and distribution in a tertiary referral center in South India

    Directory of Open Access Journals (Sweden)

    Deepak K Burad

    2012-01-01

    Full Text Available Background and Aim: Peripheral T/NK-cell lymphomas are uncommon types of non-Hodgkin′s lymphoma (NHL with a higher frequency in Far East countries as compared to the West. This study was undertaken to ascertain the frequency and distribution pattern of peripheral T-cell lymphomas (PTCLs diagnosed in a tertiary care center in South India. Materials and Methods: This retrospective study was carried out in Department of General Pathology, Christian Medical College, Vellore. The time period was for 2 years from 1 st January 2008 till 31st December 2009. All PTCLs were reviewed and classified according to the World Health Organization (WHO 2008 classification. Results: Of a total of 1032 cases of NHL, 180 cases were PTCL, which accounted for 17.4% cases of all the NHLs. Of these, PTCL, not otherwise specified (PTCL, NOS was the most common subtype (48 cases, 26.1%, followed by anaplastic large cell lymphoma (41 cases, 22.8%, mycosis fungoides (21 cases, 11.7%, angioimmunoblastic T-cell lymphoma (16 cases, 8.9%, subcutaneous panniculitis like T-cell lymphoma (15 cases, 8.4%, extranodal NK/T-cell lymphoma, nasal type (12 cases, 6.7%, and hepatosplenic T-cell lymphoma (10 cases, 5.6%. The most common primary site of presentation was nodal accounting for 42% followed by cutaneous (34%, upper aerodigestive sites (8.9%, spleen (6.7%, and gastrointestinal tract (GIT; 3.3%. Conclusions: This is the largest single study on PTCLs in India and we document that its frequency is higher than that reported in Western literature and previous Indian studies and almost similar to that reported in some Far East studies. The frequency of mycosis fungoides, subcutaneous panniculitis like T-cell lymphoma, and hepatosplenic T-cell lymphoma was higher than that reported in the World literature and previous Indian studies. The frequency of extranodal NK/T-cell lymphoma and angioimmunoblastic T-cell lymphoma was much lower than that reported in the Far East literature.

  15. Renal cell cancer histological subtype distribution differs by race and sex

    DEFF Research Database (Denmark)

    Lipworth, Loren; Morgans, Alicia K; Edwards, Todd L;

    2016-01-01

    University Medical Center (1998-2012) were classified as clear-cell, papillary, chromophobe and other subtypes. In pairwise comparisons, we used multivariate logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between race, sex, age, end-stage renal...... disease (ESRD) and body mass index at diagnosis according to histological subtype. RESULTS: The RCC subtype distribution was significantly different in black people from that in white people (P people than white...... people (35.7 vs 13.8%). In multivariate analyses, compared with clear-cell RCC, people with papillary RCC were significantly more likely to be black (OR 4.15; 95% CI 2.64-6.52) and less likely to be female (OR 0.60; 95% CI 0.43-0.83). People with chromophobe RCC were significantly more likely...

  16. An approach to estimate spatial distribution of analyte within cells using spectrally-resolved fluorescence microscopy

    Science.gov (United States)

    Sharma, Dharmendar Kumar; Irfanullah, Mir; Basu, Santanu Kumar; Madhu, Sheri; De, Suman; Jadhav, Sameer; Ravikanth, Mangalampalli; Chowdhury, Arindam

    2017-03-01

    While fluorescence microscopy has become an essential tool amongst chemists and biologists for the detection of various analyte within cellular environments, non-uniform spatial distribution of sensors within cells often restricts extraction of reliable information on relative abundance of analytes in different subcellular regions. As an alternative to existing sensing methodologies such as ratiometric or FRET imaging, where relative proportion of analyte with respect to the sensor can be obtained within cells, we propose a methodology using spectrally-resolved fluorescence microscopy, via which both the relative abundance of sensor as well as their relative proportion with respect to the analyte can be simultaneously extracted for local subcellular regions. This method is exemplified using a BODIPY sensor, capable of detecting mercury ions within cellular environments, characterized by spectral blue-shift and concurrent enhancement of emission intensity. Spectral emission envelopes collected from sub-microscopic regions allowed us to compare the shift in transition energies as well as integrated emission intensities within various intracellular regions. Construction of a 2D scatter plot using spectral shifts and emission intensities, which depend on the relative amount of analyte with respect to sensor and the approximate local amounts of the probe, respectively, enabled qualitative extraction of relative abundance of analyte in various local regions within a single cell as well as amongst different cells. Although the comparisons remain semi-quantitative, this approach involving analysis of multiple spectral parameters opens up an alternative way to extract spatial distribution of analyte in heterogeneous systems. The proposed method would be especially relevant for fluorescent probes that undergo relatively nominal shift in transition energies compared to their emission bandwidths, which often restricts their usage for quantitative ratiometric imaging in

  17. Deciduous neonatal line: Width is associated with duration of delivery.

    Science.gov (United States)

    Hurnanen, Jaana; Visnapuu, Vivian; Sillanpää, Matti; Löyttyniemi, Eliisa; Rautava, Jaana

    2017-02-01

    The delivery-related neonatal line (NNL) appears into the enamel of primary teeth and first permanent molars at birth and is a marker of live birth process. It varies in width and its location, is different in each deciduous tooth type, and is indicative of gestation time. It is unclear which triggers determine NNL at birth. Our objective was to investigate the effect of the duration and mode of delivery on NNL width. NNL of 129 teeth, a collection derived from a long-term, prospectively followed population cohort, was measured under light microscope. Altogether, 54 sections with most optimal plane of sectioning were analysed for the duration and mode of delivery. NNL was detected in 98% of the deciduous teeth with the median width of 9.63μm (min 3.16μm, max 27.58μm). A prolonged duration of vaginal delivery was highly significantly associated with a narrower NNL (r=-0.41, p=0.0097). No significant association was found between the width of NNL and mode of delivery (p=0.36). NNL is demonstrable in virtually all deciduous teeth. The width seems to be inversely proportional to the duration of delivery. Causes of the inverse proportion are speculated to result from altered amelogenesis induced by prolonged and intensified delivery-associated stress. Further research is needed to clarify the underlying mechanisms.

  18. Capacitor charging FET switcher with controller to adjust pulse width

    Science.gov (United States)

    Mihalka, A. M.

    1986-04-01

    A switching power supply includes an FET full bridge, a controller to drive the FETs, a programmable controller to dynamically control final output current by adjusting pulse width, and a variety of protective systems, including an overcurrent latch for current control. Power MOSFETS are switched at a variable frequency from 20 to 50 kHz to charge a capacitor load from 0 to 6 kV. A ferrite transformer steps up the dc input. The transformer primary is a full bridge configuration with the FET switches and the secondary is fed into a high voltage full wave rectifier whose output is connected directly to the energy storage capacitor. The peak current is held constant by varying the pulse width using predetermined timing resistors and counting pulses. The pulse width is increased as the capacitor charges to maintain peak current. A digital ripple counter counts pulses, and after the desired number is reached, an up-counter is clocked. The up-counter output is decoded to choose among different resistors used to discharge a timing capacitor, thereby determining the pulse width. A current latch shuts down the supply on overcurrent due to either excessive pulse width causing transformer saturation or a major bridge fault, i.e., FET or transformer failure, or failure of the drive circuitry.

  19. Mapping the distribution of specific antibody interaction forces on individual red blood cells

    Science.gov (United States)

    Yeow, Natasha; Tabor, Rico F.; Garnier, Gil

    2017-01-01

    Current blood typing methods rely on the agglutination of red blood cells (RBCs) to macroscopically indicate a positive result. An indirect agglutination mechanism is required when blood typing with IgG forms of antibodies. To date, the interaction forces between anti-IgG and IgG antibodies have been poorly quantified, and blood group related antigens have never been quantified with the atomic force microscope (AFM). Instead, the total intensity resulting from fluorescent-tagged antibodies adsorbed on RBC has been measured to calculate an average antigen density on a series of RBCs. In this study we mapped specific antibody interaction forces on the RBC surface. AFM cantilever tips functionalized with anti-IgG were used to probe RBCs incubated with specific IgG antibodies. This work provides unique insight into antibody-antigen interactions in their native cell-bound location, and crucially, on a per-cell basis rather than an ensemble average set of properties. Force profiles obtained from the AFM directly provide not only the anti-IgG – IgG antibody interaction force, but also the spatial distribution and density of antigens over a single cell. This new understanding might be translated into the development of very selective and quantitative interactions that underpin the action of drugs in the treatment of frontier illnesses. PMID:28157207

  20. Effect of Bcl-2 and caspase-3 on calcium distribution in apoptosis of HL-60 cells

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Apoptosis manifests in two major execution programs downstream of the death signal: the caspase pathway and organelle dysfunction. An important antiapoptosis factor, Bcl-2 protein, contributes in caspase pathway of apoptosis. Calcium, an important intracellular signal element in cells, is also observed to have changes during apoptosis, which maybe affected by Bcl2 protein. We have previously reported that in Harringtonine (HT) induced apoptosis of HL-60 cells, there's a change of intracellular calcium distribution, moving from cytoplast especially Golgi's apparatus to nucleus and accumulating there with the highest concentration. We report here that caspase-3 becomes activated in HT-induced apoptosis of HL-60 cells, which can be inhibited by overexpression of Bcl-2 protein. No sign of apoptosis or intracellular calcium movement from Golgi's apparatus to nucleus in HL-60 cells overexpressing Bcl-2 or treated with Ac-DEVD-CHO, a specific inhibitor of caspase-3. The results indicate that activated caspase-3 can promote the movement of intracellular calcium from Golgi's apparatus to nucleus, and the process is inhibited by Ac-DEVD-CHO (inhibitor of caspas-3), and that Bcl-2 can inhibit the movement and accumulation of intracellular calcium in nucleus through its inhibition on caspase3. Calcium relocalization in apoptosis seems to be irreversible, which is different from the intracellular calcium changes caused by growth factor.

  1. Mapping the distribution of specific antibody interaction forces on individual red blood cells

    Science.gov (United States)

    Yeow, Natasha; Tabor, Rico F.; Garnier, Gil

    2017-02-01

    Current blood typing methods rely on the agglutination of red blood cells (RBCs) to macroscopically indicate a positive result. An indirect agglutination mechanism is required when blood typing with IgG forms of antibodies. To date, the interaction forces between anti-IgG and IgG antibodies have been poorly quantified, and blood group related antigens have never been quantified with the atomic force microscope (AFM). Instead, the total intensity resulting from fluorescent-tagged antibodies adsorbed on RBC has been measured to calculate an average antigen density on a series of RBCs. In this study we mapped specific antibody interaction forces on the RBC surface. AFM cantilever tips functionalized with anti-IgG were used to probe RBCs incubated with specific IgG antibodies. This work provides unique insight into antibody-antigen interactions in their native cell-bound location, and crucially, on a per-cell basis rather than an ensemble average set of properties. Force profiles obtained from the AFM directly provide not only the anti-IgG – IgG antibody interaction force, but also the spatial distribution and density of antigens over a single cell. This new understanding might be translated into the development of very selective and quantitative interactions that underpin the action of drugs in the treatment of frontier illnesses.

  2. Improvement of Oxygen Diffusion Characteristic in Gas Diffusion Layer with Planar-distributed Wettability for Polymer Electrolyte Fuel Cell

    OpenAIRE

    Koresawa, Ryo; Utaka, Yoshio

    2014-01-01

    Mass transfer characteristics of gas diffusion layer (GDL) are closely related to performance of polymer electrolyte fuel cells. Therefore, it is necessary to clarify the characteristics of water distribution relating to the microscopic conformation and oxygen diffusivity of GDL. A hybrid type carbon paper GDL with planar-distributed wettability is investigated for control of liquid water movement and distribution due to hydrophobic to hydrophilic areas that provide wettability differences in...

  3. On the effect of particle size distribution on the discharge performance of nickel-metal hydride cells

    Energy Technology Data Exchange (ETDEWEB)

    Heikonen, J.M. [Center for Scientific Computing, Espoo (Finland); Nagarajan, G.S.; Zee, J.W. van [Department of Chemical Engineering, University of South Carolina, Columbia, SC (United States)

    1997-12-31

    The effect of particle size distribution on the discharge performance of nickel-metal hydride cells with mathematical models is investigated. A model with a continuous size distribution is presented and a simplified discrete version with two particle sizes is numerically analyzed for various parameter values. Simulation results are compared with experiments from another article and the deviations are analyzed. (orig.) 13 refs.

  4. Spatial distribution of human neocortical neurons and glial cells according to sex and age measured by the saucer method

    DEFF Research Database (Denmark)

    Stark, Anette Kirstine; Petersen, A O; Gardi, Jonathan Eyal;

    2007-01-01

    primary neurons in the human neocortex (divided into frontal-, temporal-, parietal- and occipital cortex) of young and old subjects free of neurological or psychological disease to test if age and gender has any influence on the cell distribution in human neocortex. Plots of the spatial distribution...

  5. All-electronic line width reduction in a semiconductor diode laser using a crystalline microresonator

    Science.gov (United States)

    Rury, Aaron S.; Mansour, Kamjou; Yu, Nan

    2015-07-01

    This study examines the capability to significantly suppress the frequency noise of a semiconductor distributed feedback diode laser using a universally applicable approach: a combination of a high-Q crystalline whispering gallery mode microresonator reference and the Pound-Drever-Hall locking scheme using an all-electronic servo loop. An out-of-loop delayed self-heterodyne measurement system demonstrates the ability of this approach to reduce a test laser's absolute line width by nearly a factor of 100. In addition, in-loop characterization of the laser stabilized using this method demonstrates a 1-kHz residual line width with reference to the resonator frequency. Based on these results, we propose that utilization of an all-electronic loop combined with the use of the wide transparency window of crystalline materials enable this approach to be readily applicable to diode lasers emitting in other regions of the electromagnetic spectrum, especially in the UV and mid-IR.

  6. Bragg reflection band width and optical rotatory dispersion of cubic blue-phase liquid crystals

    Science.gov (United States)

    Yoshida, Hiroyuki; Anucha, Konkanok; Ogawa, Yasuhiro; Kawata, Yuto; Ozaki, Masanori; Fukuda, Jun-ichi; Kikuchi, Hirotsugu

    2016-10-01

    The Bragg reflection band width and optical rotatory dispersion of liquid crystalline cholesteric blue phases (BPs) I and II are compared by numerical simulations. Attention is paid to the wavelength regions for which the reflection bands with lowest photon energies appear, i.e., the [110 ] direction for BP I and the [100 ] direction for BP II. Finite difference time domain and 4 ×4 matrix calculations performed on the theoretical director tensor distribution of BPs with the same material parameters show that BP II, which has simple cubic symmetry, has a wider photonic band gap than BP I, which has body centered cubic symmetry, possibly due to the fact that the density of the double-twist cylinders in BP II are twice that in BP I. The theoretical results on the Bragg reflection band width are supported by reflectance measurements performed on BPs I and II for light incident along the [110 ] and [100 ] directions, respectively.

  7. Variable Voltage Source Inverter with controlled frequency spectrum based on Random Pulse Width Modulation

    Directory of Open Access Journals (Sweden)

    Muhammad Farrukh Yaqub

    2012-01-01

    Full Text Available This paper presents a new method for single phase variable voltage inverter based on Random Pulse Width Modulation. In Random Pulse Width Modulation based inverter, the frequency spectrum of the output current and voltage waveforms becomes continuous because of the randomization of the switching function of the devices controlling the output voltages. This paper establishes a theory that if the distributions of the random numbers generated by the random source are kept within certain limit with respect to the peak value of reference sinusoidal waveform, the frequency spectrum can be controlled. On the basis of the results, a novel drive using variable tap changing transformer (optional and adaptive random number generator, to control the ratio between the numbers generated by the random source and the reference waveform has been suggested that will guarantee a better power quality profile for a broad range of output voltages.

  8. Predicting the distribution of spiral waves from cell properties in a developmental-path model of Dictyostelium pattern formation.

    Directory of Open Access Journals (Sweden)

    Daniel Geberth

    2009-07-01

    Full Text Available The slime mold Dictyostelium discoideum is one of the model systems of biological pattern formation. One of the most successful answers to the challenge of establishing a spiral wave pattern in a colony of homogeneously distributed D. discoideum cells has been the suggestion of a developmental path the cells follow (Lauzeral and coworkers. This is a well-defined change in properties each cell undergoes on a longer time scale than the typical dynamics of the cell. Here we show that this concept leads to an inhomogeneous and systematic spatial distribution of spiral waves, which can be predicted from the distribution of cells on the developmental path. We propose specific experiments for checking whether such systematics are also found in data and thus, indirectly, provide evidence of a developmental path.

  9. Band width and multiple-angle valence-state mapping of diamond

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez, I.; Terminello, L.J.; Sutherland, D.G.J. [Lawrence Berkeley National Lab., CA (United States)] [and others

    1997-04-01

    The band width may be considered the single most important parameter characterizing the electronic structure of a solid. The ratio of band width and Coulomb repulsion determines how correlated or delocalized an electron system is. Some of the most interesting solids straddle the boundary between localized and delocalized, e.g. the high-temperature superconductors. The bulk of the band calculations available today is based on local density functional (DF) theory. Even though the Kohn-Sham eigenvalues from that theory do not represent the outcome of a band-mapping experiment, they are remarkably similar to the bands mapped via photoemission. Strictly speaking, one should use an excited state calculation that takes the solid`s many-body screening response to the hole created in photoemission into account. Diamond is a useful prototype semiconductor because of its low atomic number and large band width, which has made it a long-time favorite for testing band theory. Yet, the two experimental values of the band width of diamond have error bars of {+-}1 eV and differ by 3.2 eV. To obtain an accurate valence band width for diamond, the authors use a band-mapping method that collects momentum distributions instead of the usual energy distributions. This method has undergone extensive experimental and theoretical tests in determining the band width of lithium fluoride. An efficient, imaging photoelectron spectrometer is coupled with a state-of-the-art undulator beam line at the Advanced Light Source to allow collection of a large number of data sets. Since it takes only a few seconds to take a picture of the photoelectrons emitted into a 84{degrees} cone, the authors can use photon energies as high as 350 eV where the cross section for photoemission from the valence band is already quite low, but the emitted photoelectrons behave free-electron-like. This make its much easier to locate the origin of the inter-band transitions in momentum space.

  10. SpatTrack: an imaging toolbox for analysis of vesicle motility and distribution in living cells.

    Science.gov (United States)

    Lund, Frederik W; Jensen, Maria Louise V; Christensen, Tanja; Nielsen, Gitte K; Heegaard, Christian W; Wüstner, Daniel

    2014-12-01

    The endocytic pathway is a complex network of highly dynamic organelles, which has been traditionally studied by quantitative fluorescence microscopy. The data generated by this method can be overwhelming and its analysis, even for the skilled microscopist, is tedious and error-prone. We developed SpatTrack, an open source, platform-independent program collecting a variety of methods for analysis of vesicle dynamics and distribution in living cells. SpatTrack performs 2D particle tracking, trajectory analysis and fitting of diffusion models to the calculated mean square displacement. It allows for spatial analysis of detected vesicle patterns including calculation of the radial distribution function and particle-based colocalization. Importantly, all analysis tools are supported by Monte Carlo simulations of synthetic images. This allows the user to assess the reliability of the analysis and to study alternative scenarios. We demonstrate the functionality of SpatTrack by performing a detailed imaging study of internalized fluorescence-tagged Niemann Pick C2 (NPC2) protein in human disease fibroblasts. Using SpatTrack, we show that NPC2 rescued the cholesterol-storage phenotype from a subpopulation of late endosomes/lysosomes (LE/LYSs). This was paralleled by repositioning and active transport of NPC2-containing vesicles to the cell surface. The potential of SpatTrack for other applications in intracellular transport studies will be discussed.

  11. Morphodynamics structures induced by variations of the channel width

    Science.gov (United States)

    Duro, Gonzalo; Crosato, Alessandra; Tassi, Pablo

    2014-05-01

    In alluvial channels, forcing effects, such as a longitudinally varying width, can induce the formation of steady bars (Olesen, 1984). The type of bars that form, such as alternate, central or multiple, will mainly depend on the local flow width-to-depth ratio and on upstream conditions (Struiksma et al., 1985). The effects on bar formation of varying the channel width received attention only recently and investigations, based on flume experiments and mathematical modelling, are mostly restricted to small longitudinal sinusoidal variations of the channel width (e.g. Repetto et al., 2002; Wu and Yeh, 2005, Zolezzi et al., 2012; Frascati and Lanzoni, 2013). In this work, we analyze the variations in equilibrium bed topography in a longitudinal width-varying channel with characteristic scales of the Waal River (The Netherlands) using two different 2D depth-averaged morphodynamic models, one based on the Delft3D code and one on Telemac-Mascaret system. In particular, we explore the effects of changing the wavelength of sinusoidal width variations in a straight channel, focusing on the effects of the spatial lag between bar formation and forcing that is observed in numerical models and laboratory experiments (e.g. Crosato et al, 2011). We extend the investigations to finite width variations in which longitudinal changes of the width-to-depth ratio are such that they may affect the type of bars that become unstable (alternate, central or multiple bars). Numerical results are qualitatively validated with field observations and the resulting morphodynamic pattern is compared with the physics-based predictor of river bar modes by Crosato and Mosselman (2009). The numerical models are finally used to analyse the experimental conditions of Wu and Yeh (2005). The study should be seen as merely exploratory. The aim is to investigate possible approaches for future research aiming at assessing the effects of artificial river widening and narrowing to control bar formation in

  12. Interatomic Coulombic decay widths of helium trimer: Ab initio calculations

    Energy Technology Data Exchange (ETDEWEB)

    Kolorenč, Přemysl, E-mail: kolorenc@mbox.troja.mff.cuni.cz [Charles University in Prague, Faculty of Mathematics and Physics, Institute of Theoretical Physics, V Holešovičkách 2, 180 00 Prague (Czech Republic); Sisourat, Nicolas [Sorbonne Universités, UPMC Univ Paris 06, UMR 7614, Laboratoire de Chimie Physique Matière et Rayonnement, F-75005 Paris (France); CNRS, UMR 7614, Laboratoire de Chimie Physique Matière et Rayonnement, F-75005 Paris (France)

    2015-12-14

    We report on an extensive study of interatomic Coulombic decay (ICD) widths in helium trimer computed using a fully ab initio method based on the Fano theory of resonances. Algebraic diagrammatic construction for one-particle Green’s function is utilized for the solution of the many-electron problem. An advanced and universal approach to partitioning of the configuration space into discrete states and continuum subspaces is described and employed. Total decay widths are presented for all ICD-active states of the trimer characterized by one-site ionization and additional excitation of an electron into the second shell. Selected partial decay widths are analyzed in detail, showing how three-body effects can qualitatively change the character of certain relaxation transitions. Previously unreported type of three-electron decay processes is identified in one class of the metastable states.

  13. Optimal operation management of fuel cell/wind/photovoltaic power sources connected to distribution networks

    Science.gov (United States)

    Niknam, Taher; Kavousifard, Abdollah; Tabatabaei, Sajad; Aghaei, Jamshid

    2011-10-01

    In this paper a new multiobjective modified honey bee mating optimization (MHBMO) algorithm is presented to investigate the distribution feeder reconfiguration (DFR) problem considering renewable energy sources (RESs) (photovoltaics, fuel cell and wind energy) connected to the distribution network. The objective functions of the problem to be minimized are the electrical active power losses, the voltage deviations, the total electrical energy costs and the total emissions of RESs and substations. During the optimization process, the proposed algorithm finds a set of non-dominated (Pareto) optimal solutions which are stored in an external memory called repository. Since the objective functions investigated are not the same, a fuzzy clustering algorithm is utilized to handle the size of the repository in the specified limits. Moreover, a fuzzy-based decision maker is adopted to select the 'best' compromised solution among the non-dominated optimal solutions of multiobjective optimization problem. In order to see the feasibility and effectiveness of the proposed algorithm, two standard distribution test systems are used as case studies.

  14. Analysis on Longitudinal Dose according to Change of Field Width

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Won Seok; Shin, Ryung Mi; Oh, Byung Cheon; Jo, Jun Young; Kim, Gi Chul; Choi, Tae Gu [Dept. of Radiation Oncology, Kyunghee University Hospital, Seoul (Korea, Republic of); Back, Jong Geal [Dept. of Radiation Oncology, Yensei Caner Center, Seoul (Korea, Republic of)

    2011-09-15

    To analyze the accuracy of tumor volume dose following field width change, to check the difference of dose change by using self-made moving car, and to evaluate practical delivery tumor dose when tomotherapy in the treatment of organ influenced by breathing. By using self-made moving car, the difference of longitudinal movement (0.0 cm, 1.0 cm, 1.5 cm, 2.0 cm) was applied and compared calculated dose with measured dose according to change of field width (1.05 cm, 2.50 cm, 5.02 cm) and apprehended margin of error. Then done comparative analysis in degree of photosensitivity of DQA film measured by using Gafchromic EBT film. Dose profile and Gamma histogram were used to measure degree of photosensitivity of DQA film. When field width were 1.05 cm, 2.50 cm, 5.02 cm, margin of error of dose delivery coefficient was -2.00%, -0.39%, -2.55%. In dose profile of Gafchromic EBT film's analysis, the movement of moving car had greater motion toward longitudinal direction and as field width was narrower, big error increased considerably at high dose part compared to calculated dose. The more field width was narrowed, gamma index had a large considerable influence of moving at gamma histogram. We could check the difference of longitudinal dose of moving organ. In order to small field width and minimize organ moving due to breathing, it is thought to be needed to develop breathing control unit and fixation tool.

  15. Distinct axo-somato-dendritic distributions of three potassium channels in CA1 hippocampal pyramidal cells.

    Science.gov (United States)

    Kirizs, Tekla; Kerti-Szigeti, Katalin; Lorincz, Andrea; Nusser, Zoltan

    2014-06-01

    Potassium channels comprise the most diverse family of ion channels and play critical roles in a large variety of physiological and pathological processes. In addition to their molecular diversity, variations in their distributions and densities on the axo-somato-dendritic surface of neurons are key parameters in determining their functional impact. Despite extensive electrophysiological and anatomical investigations, the exact location and densities of most K(+) channels in small subcellular compartments are still unknown. Here we aimed at providing a quantitative surface map of two delayed-rectifier (Kv1.1 and Kv2.1) and one G-protein-gated inwardly rectifying (Kir3.2) K(+) channel subunits on hippocampal CA1 pyramidal cells (PCs). Freeze-fracture replica immunogold labelling was employed to determine the relative densities of these K(+) channel subunits in 18 axo-somato-dendritic compartments. Significant densities of the Kv1.1 subunit were detected on axon initial segments (AISs) and axon terminals, with an approximately eight-fold lower density in the latter compartment. The Kv2.1 subunit was found in somatic, proximal dendritic and AIS plasma membranes at approximately the same densities. This subunit has a non-uniform plasma membrane distribution; Kv2.1 clusters are frequently adjacent to, but never overlap with, GABAergic synapses. A quasi-linear increase in the Kir3.2 subunit density along the dendrites of PCs was detected, showing no significant difference between apical dendritic shafts, oblique dendrites or dendritic spines at the same distance from the soma. Our results demonstrate that each subunit has a unique cell-surface distribution pattern, and predict their differential involvement in synaptic integration and output generation at distinct subcellular compartments.

  16. Measuring slit width and separation in a diffraction experiment

    Energy Technology Data Exchange (ETDEWEB)

    Gan, K K; Law, A T [Department of Physics, Ohio State University, Columbus, OH 43210 (United States)], E-mail: gan@mps.ohio-state.edu

    2009-11-15

    We present a procedure for measuring slit width and separation in single- and double-slit diffraction experiments. Intensity spectra of diffracted laser light are measured with an optical sensor (PIN diode). Slit widths and separations are extracted by fitting to the measured spectra. We present a simple fitting procedure to account for the integration (averaging) of light across the finite sensor aperture. This experiment provides students with a quantitative, in-depth verification of diffraction theory, as well as hands-on experience in sophisticated fitting methods.

  17. Development and distribution of mast cells and neuropeptides in human fetus duodenum

    Institute of Scientific and Technical Information of China (English)

    Xiao-Yu Chen; Xue-Mei Jia; You-Su Jia; Xiao-Rong Chen; Hui-Zhu Wang; Wei-Qin Qi

    2004-01-01

    AIM: To study the developmental regularities and heterogeneity of mast cells (MC) in human fetus duodenum and the distribution and developmental regularities of substance P(SP), calcitonin gene-related peptide (CGRP)-immunoreactive (IR) peptidergic nerves in fetus duodenum,as well as the relationship between MC, SP and CGRP- IR peptidergic nerves.METHODS: Duodena from 21 cases of human fetus and one term infant were stained by hematoxylin-eosin (HE),toluidine blue (TB) and immunohistochemical avidin-biotinylated peroxidase complex (ABC) method.RESULTS: Lobe-shape intestinal villi in duodenum were already developed at the twelfth week. At the 21st wk,muscular mucosa appeared gradually, and four layers were observed in the wall of duodenum. TB staining showed that the granules in the immature MC were pale violet,while the mature MC were strong violet in color by TB staining. Connective tissue MC (CTMC) appeared occasionally in submucosa and muscular layer of duodenum at the16th wk. While the mucosa MC (MMC) appeared at the18th wk. At the 22nd wk, both CTMC and MMC were activated, and distributed in the surrounding blood vessels and ganglions. The verge of some MC were unclear, and showed degranular phenomena. At the 14th wk, SP and CGRP-IR nerve fibers and cells appeared in the myenteric and submucous plexuses in small intestine, and the responses were turn strongly. Neurons were light to deep brown, and nerve fibers were present as varicose and liner profiles. On the corresponding site of serial sections, SP and CGRP immunohistochemical reactions were coexisted in one nerve fiber or cell. Some of MC showed SP and CGRP-IR positive staining.CONCLUSION: There are two heterogeneous kinds of MC in duodenum, MMC and CTMC. MC might play an important role in regulating blood circulation and sensation.

  18. ZTEK`s ultra-high efficiency fuel cell/gas turbine system for distributed generation

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, M.; Nathanson, D. [Ztek Corp., Waltham, MA (United States); Bradshaw, D.T. [Tennessee Valley Authority, Chattanooga, TN (United States)] [and others

    1996-12-31

    Ztek`s Planar Solid Oxide Fuel Cell (SOFC) system has exceptional potential for utility electric power generation because of: simplicity of components construction, capability for low cost manufacturing, efficient recovery of very high quality by-product heat (up to 1000{degrees}C), and system integration simplicity. Utility applications of the Solid Oxide Fuel Cell are varied and include distributed generation units (sub-MW to 30MW capacity), repowering existing power plants (i.e. 30MW to 100MW), and multi-megawatt central power plants. A TVA/EPRI collaboration program involved functional testing of the advanced solid oxide fuel cell stacks and design scale-up for distributed power generation applications. The emphasis is on the engineering design of the utility modules which will be the building blocks for up to megawatt scale power plants. The program has two distinctive subprograms: Verification test on a 1 kW stack and 25kW module for utility demonstration. A 1 kW Planar SOFC stack was successfully operated for 15,000 hours as of December, 1995. Ztek began work on a 25kW SOFC Power System for TVA, which plans to install the 25kW SOFC at a host site for demonstration in 1997. The 25kW module is Ztek`s intended building block for the commercial use of the Planar SOFC. Systems of up to megawatt capacity can be obtained by packaging the modules in 2-dimensional or 3-dimensional arrays.

  19. Measuring the extent and width of internal energy deposition in ion activation using nanocalorimetry.

    Science.gov (United States)

    Donald, William A; Williams, Evan R

    2010-04-01

    The recombination energies resulting from electron capture by a positive ion can be accurately measured using hydrated ion nanocalorimetry in which the internal energy deposition is obtained from the number of water molecules lost from the reduced cluster. The width of the product ion distribution in these experiments is predominantly attributable to the distribution of energy that partitions into the translational and rotational modes of the water molecules that are lost. These results are consistent with a singular value for the recombination energy. For large clusters, the width of the energy distribution is consistent with rapid energy partitioning into internal vibrational modes. For some smaller clusters with high recombination energies, the measured product ion distribution is narrower than that calculated with a statistical model. These results indicate that initial water molecule loss occurs on the time scale of, or faster than energy randomization. This could be due to inherently slow internal conversion or it could be due to a multi-step process, such as initial ion-electron pair formation followed by reduction of the ion in the cluster. These results provide additional evidence for the accuracy with which condensed phase thermochemical values can be deduced from gaseous nanocalorimetry experiments.

  20. Estimation of Velocity Profile Based on Chiu’s Equation in Width of Channels

    Directory of Open Access Journals (Sweden)

    Saman Nikmehr

    2010-08-01

    Full Text Available Distribution of velocity in channel is one of the most parameters for solution of hydraulic problems. Determination of energy coefficient, momentum and distribution of sediment concentration depend on distribution of velocity profile. The entropy parameter of a channel section can be determined from the relation between the mean and maximum velocities. A technique has been developed to determine a velocity profile on a single vertical passing through the point of maximum velocity in a channel cross section. This method is a way in order to quick and cheap estimating of velocity distribution with high accuracy in channels. So that in this research the power estimation of Chiu method base on entropy concept was determined. Also Chiu’s equation that is based on entropy concept and probability domain, has compared with logarithmic and exponential equations to estimation of velocity profile in width of channel in various depths. The results show that Chiu’s equation better than logarithmic and exponential equations to estimation of velocity profile in width of channel.

  1. Distribution of Nitric Oxide-Producing Cells along Spinal Cord in Urodeles

    Directory of Open Access Journals (Sweden)

    Mayada A Mahmoud

    2014-09-01

    Full Text Available Nitric oxide is a unique neurotransmitter, which participates in many physiological and pathological processes in the organism. There are little data about the neuronal nitric oxide synthase immunoreactivity in the spinal cord of amphibians. In this respect, the present study aims to investigate the distribution of nitric oxide producing cells in the spinal cord of urodele and to find out the possibility of a functional locomotory role to this neurotransmitter. The results of the present study demonstrate a specific pattern of NADPH-d labeling in the selected amphibian model throughout the spinal cord length as NADPH-d-producing cells and fibres were present in almost all segments of the spinal cord of the salamander investigated. However, their number, cytological characteristics and labeling intensity varied significantly. It was noticed that the NO-producing cells (NO-PC were accumulated in the ventral side of certain segments in the spinal cord corresponding to the brachial and sacral plexuses. In addition, the number of NO-PC was found to be increased also at the beginning of the tail and this could be due to the fact that salamanders are tetrapods having bimodal locomotion, namely swimming and walking.

  2. Skewed distribution of IL-7 receptor-α-expressing effector memory CD8+ T cells with distinct functional characteristics in oral squamous cell carcinoma.

    Directory of Open Access Journals (Sweden)

    Jang-Jaer Lee

    Full Text Available CD8(+ T cells play important roles in anti-tumor immunity but distribution profile or functional characteristics of effector memory subsets during tumor progression are unclear. We found that, in oral squamous carcinoma patients, circulating CD8(+ T cell pools skewed toward effector memory subsets with the distribution frequency of CCR7(-CD45RA(-CD8(+ T cells and CCR7(- CD45RA(+CD8(+ T cells negatively correlated with each other. A significantly higher frequency of CD127(lo CCR7(-CD45RA(-CD8(+ T cells or CCR7(-CD45RA(+CD8(+ T cells among total CD8(+ T cells was found in peripheral blood or tumor infiltrating lymphocytes, but not in regional lymph nodes. The CD127(hi CCR7(-CD45RA(-CD8(+ T cells or CCR7(-CD45RA(+CD8(+ T cells maintained significantly higher IFN-γ, IL-2 productivity and ex vivo proliferative capacity, while the CD127(lo CCR7(-CD45RA(-CD8(+ T cells or CCR7(-CD45RA(+CD8(+ T cells exhibited higher granzyme B productivity and susceptibility to activation induced cell death. A higher ratio of CCR7(-CD45RA(+CD8(+ T cells to CCR7(-CD45RA(-CD8(+ T cells was associated with advanced cancer staging and poor differentiation of tumor cells. Therefore, the CD127(lo CCR7(-CD45RA(-CD8(+ T cells and CCR7(-CD45RA(+CD8(+ T cells are functionally similar CD8(+ T cell subsets which exhibit late differentiated effector phenotypes and the shift of peripheral CD8(+ effector memory balance toward CCR7(-CD45RA(+CD8(+ T cells is associated with OSCC progression.

  3. Distribution and localization of fibroblast growth factor-8 in rat brain and nerve cells during neural stem/progenitor cell differentiation

    Institute of Scientific and Technical Information of China (English)

    Jiang Lu; Dongsheng Li; Kehuan Lu

    2012-01-01

    The present study explored the distribution and localization of fibroblast growth factor-8 and its potential receptor,fibroblast growth factor receptor-3,in adult rat brain in vivo and in nerve cells during differentiation of neural stem/progenitor cells in vitro.Immunohistochemistry was used to examine the distribution of fibroblast growth factor-8 in adult rat brain in vivo.Localization of fibroblast growth factor-8 and fibroblast growth factor receptor-3 in cells during neural stem/progenitor cell differentiation in vitro was detected by immunofluorescence.Flow cytometry and immunofluorescence were used to evaluate the effect of an anti-fibroblast growth factor-8 antibody on neural stem/progenitor cell differentiation and expansion in vitro.Results from this study confirmed that fibroblast growth factor-8 was mainly distributed in adult midbrain,namely the substantia nigra,compact part,dorsal tier,substantia nigra and reticular part,but was not detected in the forebrain comprising the caudate putamen and striatum.Unusual results were obtained in retrosplenial locations of adult rat brain.We found that fibroblast growth factor-8 and fibroblast growth factor receptor-3 were distributed on the cell membrane and in the cytoplasm of nerve cells using immunohistochemistry and immunofluorescence analyses.We considered that the distribution of fibroblast growth factor-8 and fibroblast growth factor receptor-3 in neural cells corresponded to the characteristics of fibroblast growth factor-8,a secretory factor.Addition of an anti-fibroblast growth factor-8 antibody to cultures significantly affected the rate of expansion and differentiation of neural stem/progenitor cells.In contrast,addition of recombinant fibroblast growth factor-8 to differentiation medium promoted neural stem/progenitor cell differentiation and increased the final yields of dopaminergic neurons and total neurons.Our study may help delineate the important roles of fibroblast growth factor-8 in brain

  4. Ganglion cell size and distribution in the retina of the two-toed sloth (Choloepus didactylus L.).

    Science.gov (United States)

    Andrade-da-Costa, B L; Pessoa, V F; Bousfield, J D; Clarke, R J

    1989-01-01

    The distribution of ganglion cell densities and sizes was studied in Nissl-stained flat-mount retinae of the two-toed sloth. The area centralis, a weak specialization with low ganglion cell density, is located in the temporal retina close to the center of the eye. The presence of a visual streak was noted. The distribution of different ganglion cell sizes was approximately equal throughout the retina. Although the retinal organization differs from that of the closely related three-toed sloth, the presumed function of retinal specializations in both species is to guide limb movements by permitting visualization of the branch along which the animal is climbing.

  5. A Measurement of the Total Width, the Electronic Width, and the Mass of the Upsilon(10580) Resonance

    CERN Document Server

    Aubert, B; Boutigny, D; Couderc, F; Gaillard, J M; Hicheur, A; Karyotakis, Yu; Lees, J P; Tisserand, V; Zghiche, A; Palano, A; Pompili, A; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Borgland, A W; Breon, A B; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Day, C T; Gill, M S; Gritsan, A V; Groysman, Y; Jacobsen, R G; Kadel, R W; Kadyk, J; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Le Clerc, C; Lynch, G; Merchant, A M; Mir, L M; Oddone, P J; Orimoto, T J; Pripstein, M; Roe, N A; Ronan, Michael T; Shelkov, V G; Telnov, A V; Wenzel, W A; Ford, K; Harrison, T J; Hawkes, C M; Morgan, S E; Watson, A T; Fritsch, M; Goetzen, K; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Steinke, M; Boyd, J T; Chevalier, N; Cottingham, W N; Kelly, M P; Latham, T E; Wilson, F F; Çuhadar-Dönszelmann, T; Hearty, C; Mattison, T S; McKenna, J A; Thiessen, D; Kyberd, P; Teodorescu, L; Blinov, V E; Bukin, A D; Druzhinin, V P; Golubev, V B; Ivanchenko, V N; Kravchenko, E A; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Yushkov, A N; Best, D; Bruinsma, M; Chao, M; Eschrich, I; Kirkby, D; Lankford, A J; Mandelkern, M A; Mommsen, R K; Röthel, W; Stoker, D P; Buchanan, C; Hartfiel, B L; Gary, J W; Shen, B C; Wang, K; Del Re, D; Hadavand, H K; Hill, E J; MacFarlane, D B; Paar, H P; Rahatlou, S; Sharma, V; Berryhill, J W; Campagnari, C; Dahmes, B; Levy, S L; Long, O; Lu, A; Mazur, M A; Richman, J D; Verkerke, W; Beck, T W; Eisner, A M; Heusch, C A; Lockman, W S; Schalk, T; Schmitz, R E; Schumm, B A; Seiden, A; Spradlin, P; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dubois-Felsmann, G P; Dvoretskii, A; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Ryd, A; Samuel, A; Yang, S; Jayatilleke, S M; Mancinelli, G; Meadows, B T; Sokoloff, M D; Abe, T; Blanc, F; Bloom, P; Chen, S; Clark, P J; Ford, W T; Nauenberg, U; Olivas, A; Rankin, P; Smith, J G; Zhang, L; Chen, A; Harton, J L; Soffer, A; Toki, W H; Wilson, R J; Zeng, Q L; Altenburg, D; Brandt, T; Brose, J; Colberg, T; Dickopp, M; Feltresi, E; Hauke, A; Lacker, H M; Maly, E; Müller-Pfefferkorn, R; Nogowski, R; Otto, S; Petzold, A; Schubert, J; Schubert, Klaus R; Schwierz, R; Spaan, B; Sundermann, J E; Bernard, D; Bonneaud, G R; Brochard, F; Grenier, P; Schrenk, S; Thiebaux, C; Vasileiadis, G; Verderi, M; Bard, D J; Khan, A; Lavin, D; Muheim, F; Playfer, S; Andreotti, M; Azzolini, V; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Luppi, E; Negrini, M; Piemontese, L; Sarti, A; Treadwell, E; Baldini-Ferroli, R; Calcaterra, A; De Sangro, R; Finocchiaro, G; Patteri, P; Piccolo, M; Zallo, A; Buzzo, A; Capra, R; Contri, R; Crosetti, G; Lo Vetere, M; Macri, M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Bailey, S; Brandenburg, G; Morii, M; Won, E; Dubitzky, R S; Langenegger, U; Bhimji, W; Bowerman, D A; Dauncey, P D; Egede, U; Gaillard, J R; Morton, G W; Nash, J A; Taylor, G P; Grenier, G J; Mallik, U; Cochran, J; Crawley, H B; Lamsa, J; Meyer, W T; Prell, S; Rosenberg, E I; Yi, J; Davier, M; Grosdidier, G; Höcker, A; Laplace, S; Le Diberder, F R; Lepeltier, V; Lutz, A M; Petersen, T C; Plaszczynski, S; Schune, M H; Tantot, L; Wormser, G; Cheng, C H; Lange, D J; Simani, M C; Wright, D M; Bevan, A J; Coleman, J P; Fry, J R; Gabathuler, Erwin; Gamet, R; Parry, R J; Payne, D J; Sloane, R J; Touramanis, C; Back, J J; Cormack, C M; Harrison, P F; Mohanty, G B; Brown, C L; Cowan, G; Flack, R L; Flächer, H U; Green, M G; Marker, C E; McMahon, T R; Ricciardi, S; Salvatore, F; Vaitsas, G; Winter, M A; Brown, D; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Hart, P A; Hodgkinson, M C; Lafferty, G D; Lyon, A J; Williams, J C; Farbin, A; Hulsbergen, W D; Jawahery, A; Kovalskyi, D; Lae, C K; Lillard, V; Roberts, D A; Blaylock, G; Dallapiccola, C; Flood, K T; Hertzbach, S S; Kofler, R; Koptchev, V B; Moore, T B; Saremi, S; Stängle, H; Willocq, S; Cowan, R; Sciolla, G; Taylor, F; Yamamoto, R K; Mangeol, D J J; Patel, P M; Robertson, S H; Lazzaro, A; Palombo, F; Bauer, J M; Cremaldi, L M; Eschenburg, V; Godang, R; Kroeger, R; Reidy, J; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Taras, P; Nicholson, H; Cavallo, N; Fabozzi, F; Gatto, C; Lista, L; Monorchio, D; Paolucci, P; Piccolo, D; Sciacca, C; Baak, M; Bulten, H; Raven, G; Wilden, L; Jessop, C P; LoSecco, J M; Gabriel, T A; Allmendinger, T; Brau, B; Gan, K K; Honscheid, K; Hufnagel, D; Kagan, H; Kass, R; Pulliam, T; Rahimi, A M; Ter-Antonian, R; Wong, Q K; Brau, J E; Frey, R; Igonkina, O; Potter, C T; Sinev, N B; Strom, D; Torrence, E; Colecchia, F; Dorigo, A; Galeazzi, F; Margoni, M; Morandin, M; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Tiozzo, G; Voci, C; Benayoun, M; Briand, H; Chauveau, J; David, P; La Vaissière, C de; Del Buono, L; Hamon, O; John, M J J; Leruste, P; Ocariz, J; Pivk, M; Roos, L; T'Jampens, S; Therin, G; Manfredi, P F; Re, V; Behera, P K; Gladney, L; Guo, Q H; Panetta, J; Anulli, F; Biasini, M; Peruzzi, I M; Pioppi, M; Angelini, C; Batignani, G; Bettarini, S; Bondioli, M; Bucci, F; Calderini, G; Carpinelli, M; Del Gamba, V; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Martínez-Vidal, F; Morganti, M; Neri, N; Paoloni, E; Rama, M; Rizzo, G; Sandrelli, F; Walsh, J; Haire, M; Judd, D; Paick, K; Wagoner, D E; Danielson, N; Elmer, P; Lü, C; Miftakov, V; Olsen, J; Smith, A J S; Bellini, F; Cavoto, G; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Li Gioi, L; Mazzoni, M A; Morganti, S; Pierini, M; Piredda, G; Safai-Tehrani, F; Voena, C; Christ, S; Wagner, G; Waldi, R; Adye, T; De Groot, N; Franek, B J; Geddes, N I; Gopal, G P; Olaiya, E O; Aleksan, Roy; Emery, S; Gaidot, A; Ganzhur, S F; Giraud, P F; Hamel de Monchenault, G; Kozanecki, Witold; Langer, M; Legendre, M; London, G W; Mayer, B; Schott, G; Vasseur, G; Yéche, C; Zito, M; Purohit, M V; Weidemann, A W; Yumiceva, F X; Aston, D; Bartoldus, R; Berger, N; Boyarski, A M; Buchmüller, O L; Convery, M R; Cristinziani, M; De Nardo, Gallieno; Donald, M; Dong, D; Dorfan, J; Dujmic, D; Dunwoodie, W M; Elsen, E E; Fan, S; Field, R C; Fisher, A; Glanzman, T; Gowdy, S J; Hadig, T; Halyo, V; Hast, C; Hrynóva, T; Innes, W R; Kelsey, M H; Kim, P; Kocian, M L; Leith, D W G S; Libby, J; Luitz, S; Lüth, V; Lynch, H L; Marsiske, H; Messner, R; Müller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Petrak, S; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Seeman, J; Simi, G; Snyder, A; Soha, A; Stelzer, J; Su, D; Sullivan, M K; Vavra, J; Wagner, S R; Weaver, M; Weinstein, A J R; Wienands, U; Wisniewski, W J; Wittgen, M; Wright, D H; Yarritu, A K; Young, C C; Burchat, Patricia R; Edwards, A J; Meyer, T I; Petersen, B A; Roat, C; Ahmed, S; Alam, M S; Ernst, J A; Saeed, M A; Saleem, M; Wappler, F R; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Kim, H; Ritchie, J L; Satpathy, A; Schwitters, R F; Izen, J M; Kitayama, I; Lou, X C; Ye, S; Bianchi, F; Bóna, M; Gallo, F; Gamba, D; Borean, C; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Dittongo, S; Grancagnolo, S; Lanceri, L; Poropat, P; Vitale, L; Vuagnin, G; Panvini, R S; Banerjee, Sw; Brown, C M; Fortin, D; Jackson, P D; Kowalewski, R V; Roney, J M; Band, H R; Dasu, S; Datta, M; Eichenbaum, A M; Hollar, J J; Johnson, J R; Kutter, P E; Li, H; Liu, R; Di Lodovico, F; Mihályi, A; Mohapatra, A K; Pan, Y; Prepost, R; Sekula, S J; Tan, P; Von Wimmersperg-Töller, J H; Wu, J; Wu, S L; Yu, Z; Neal, H

    2004-01-01

    We present a measurement of the parameters of the $\\Upsilon(10580)$ resonance based on a dataset collected with the BABAR detector at the SLAC PEP-II asymmetric $B$ factory. We measure the total width $\\Gamma_{\\rm tot}$ to be $(20.7\\pm1.6\\pm2.5) {\\rm MeV}$, the electronic partial width $\\Gamma_{ee} = (0.321\\pm0.017\\pm0.029) {\\rm keV}$ and the mass $M = (10579.3\\pm0.4\\pm1.2) {\\rm MeV/c^2}$.

  6. Echo width of foam supports used in scattering measurements

    DEFF Research Database (Denmark)

    Appel-Hansen, Jørgen; Solodukhov, V. V.

    1979-01-01

    Theoretically and experimentally determined echo widths of dielectric cylinders having circular, triangular, and quadratic cross sections have been compared. The cylinders were made of foam material having a relative dielectric constant of about 1.035. The purpose of the investigation was to find...

  7. Quality of pedestrian flow and crosswalk width at signalized intersections

    Directory of Open Access Journals (Sweden)

    Wael K.M. Alhajyaseen

    2010-07-01

    Full Text Available Among various pedestrian facilities, signalized crosswalks are the most complex and critical ones. Their geometry and configuration including width, position and angle directly affect the safety, cycle length and resulting delays for all users. Existing manuals do not provide clear and rational specifications for the required crosswalk width under different pedestrian demand combinations and properties. Furthermore, they do not consider the bi-directional flow effects on crossing speed and time when addressing pedestrian flow at signalized crosswalks. However, quantifying the effects of such interactions on the behavior of pedestrian flow is a prerequisite for improving the geometric design and configuration of signalized crosswalks. The objective of this paper is to develop a methodology for estimating the required crosswalk width at different pedestrian demand combinations and a pre-defined LOS. The developed methodology is based on theoretical modeling for total pedestrian platoon crossing time, which consists of discharge and crossing times. The developed models are utilized to generate the fundamental diagrams of pedestrian flow at signalized crosswalks. A comprehensive discussion about the effects of bi-directional flow and various pedestrian age groups on the characteristics of pedestrian flow and the capacity of signalized crosswalks is presented. It is found that the maximum reduction in the capacity of signalized crosswalks occurs at roughly equal pedestrian flows from both sides of the crosswalk. By utilizing existing LOS thresholds for pedestrian flow at signalized crosswalks, the required crosswalk widths for various pedestrian demand combinations are proposed for implementation.

  8. Directed path-width and monotonicity in digraph searching

    DEFF Research Database (Denmark)

    Barat, Janos

    2006-01-01

    Directed path-width was defined by Reed, Thomas and Seymour around 1995. The author and P. Hajnal defined a cops-and-robber game on digraphs in 2000. We prove that the two notions are closely related and for any digraph D, the corresponding graph parameters differ by at most one. The result is ac...

  9. TWO FEEDBACK PROBLEMS FOR GRAPHS WITH BOUNDED TREE-WIDTH

    Institute of Scientific and Technical Information of China (English)

    ZhangShaoqiang; LiGuojun; SohnMoo-Young

    2004-01-01

    Many difficult (often NP-complete) optimization problems can be solved efficiently on graphs of small tree-width with a given tree decomposition. In this paper,it is discussed how to solve the minimum feedback vertex set problem and the minimum vertex feedback edge set problem efficiently by using dynamic programming on a tree-decomposition.

  10. Synaptic channel model including effects of spike width variation

    OpenAIRE

    2015-01-01

    Synaptic Channel Model Including Effects of Spike Width Variation Hamideh Ramezani Next-generation and Wireless Communications Laboratory (NWCL) Department of Electrical and Electronics Engineering Koc University, Istanbul, Turkey Ozgur B. Akan Next-generation and Wireless Communications Laboratory (NWCL) Department of Electrical and Electronics Engineering Koc University, Istanbul, Turkey ABSTRACT An accu...

  11. Potential dominance of oscillating crescent waves in finite width tanks

    DEFF Research Database (Denmark)

    Fuhrman, David R.; Madsen, Per A.

    2005-01-01

    Recently, it has been proposed that the emergence of previously observed oscillating crescent water wave patterns, created by class II (three-dimensional) instabilities which are in principle not dominant, could in fact be explained as an artifact of a finite width tank, combined with a suppression...

  12. Rinsing Processes in Open-width Washing Machines

    NARCIS (Netherlands)

    Kroezen, A.B.J.; Linden, van der H.J.L.J.; Groot Wassink, J.

    1986-01-01

    A simulator is described for rinsing processes carried out on open-width washing machines. In combination with a theoretical model, a simple method is given for testing rinsing processes. The method has been used to investigate the extraction of caustic soda from a cotton fabric, varying the tempera

  13. Improved determination of the width of the top quark

    Energy Technology Data Exchange (ETDEWEB)

    Abazov V. M.; Abbott B.; Acharya B. S.; Adams M.; Adams T.; Alexeev G. D.; Alkhazov G.; Alton A.; Alverson G.; Aoki M.; Askew A.; Asman B.; Atkins S.; Atramentov O.; Augsten K.; Avila C.; BackusMayes J.; Badaud F.; Bagby L.; Baldin B.; Bandurin D. V.; Banerjee S.; Barberis E.; Baringer P.; Barreto J.; Bartlett J. F.; Bassler U.; Bazterra V.; Bean A.; Begalli M.; Belanger-Champagne C.; Bellantoni L.; Beri S. B.; Bernardi G.; Bernhard R.; Bertram I.; Besancon M.; Beuselinck R.; Bezzubov V. A.; Bhat P. C.; Bhatia S.; Bhatnagar V.; Blazey G.; Blessing S.; Bloom K.; Boehnlein A.; Boline D.; Boos E. E.; Borissov G.; Bose T.; Brandt A.; Brandt O.; Brock R.; Brooijmans G.; Bross A.; Brown D.; Brown J.; Bu X. B.; Buehler M.; Buescher V.; Bunichev V.; Burdin S.; Burnett T. H.; Buszello C. P.; Calpas B.; Camacho-Perez E.; Carrasco-Lizarraga M. A.; Casey C. K.; Castilla-Valdez H.; Chakrabarti S.; Chakraborty D.; Chan M.; Chandra A.; Chapon E.; Chen G.; Chevalier-Thery S.; Cho D. K.; Cho S. W.; Choi S.; Choudhary B.; Cihangir S.; Claes D.; Clutter J.; Cooke M.; Cooper W. E.; Corcoran M.; Couderc F.; Cousinou M. -C.; Croc A.; Cutts D.; Das A.; Davies G.; de Jong S. J.; De La Cruz-Burelo E.; Deliot F.; Demina R.; Denisov D.; Denisov S. P.; Desai S.; Deterre C.; DeVaughan K.; Diehl H. T.; Diesburg M.; Ding P. F.; Dominguez A.; Dorland T.; Dubey A.; Dudko L. V.; Duggan D.; Duperrin A.; Dutt S.; Dyshkant A.; Eads M.; Edmunds D.; Ellison J.; Elvira V. D.; Enari Y.; Evans H.; Evdokimov A.; Evdokimov V. N.; Facini G.; Ferbel T.; Fiedler F.; Filthaut F.; Fisher W.; Fisk H. E.; Fortner M.; Fox H.; Fuess S.; Garcia-Bellido A.; Garcia-Guerra G. A.; Gavrilov V.; Gay P.; Geng W.; Gerbaudo D.; Gerber C. E.; Gershtein Y.; Ginther G.; Golovanov G.; Goussiou A.; Graf C. P.; Grannis P. D.; Greder S.; Greenlee H.; Greenwood Z. D.; Gregores E. M.; Grenier G.; Gris Ph.; Grivaz J. -F.; Grohsjean A.; Gruenendahl S.; Gruenewald M. W.; Guillemin T.; Gutierrez G.; Gutierrez P.; Haas A.; Hagopian S.; Haley J.; Han L.; Harder K.; Harel A.; Hauptman J. M.; Hays J.; Head T.; Hebbeker T.; Hedin D.; Hegab H.; Heinson A. P.; Heintz U.; Hensel C.; La Cruz I. Heredia-De; Herner K.; Hesketh G.; Hildreth M. D.; Hirosky R.; Hoang T.; Hobbs J. D.; Hoeneisen B.; Hohlfeld M.; Hubacek Z.; Hynek V.; Iashvili I.; Ilchenko Y.; Illingworth R.; Ito A. S.; Jabeen S.; Jaffre M.; Jamin D.; Jayasinghe A.; Jesik R.; Johns K.; Johnson M.; Jonckheere A.; Jonsson P.; Joshi J.; Jung A. W.; Juste A.; Kaadze K.; Kajfasz E.; Karmanov D.; Kasper P. A.; Katsanos I.; Kehoe R.; Kermiche S.; Khalatyan N.; Khanov A.; Kharchilava A.; Kharzheev Y. N.; Kohli J. M.; Kozelov A. V.; Kraus J.; Kulikov S.; Kumar A.; Kupco A.; Kurca T.; Kuzmin V. A.; Lammers S.; Landsberg G.; Lebrun P.; Lee H. S.; Lee S. W.; Lee W. M.; Lellouch J.; Li H.; Li L.; Li Q. Z.; Lietti S. M.; Lim J. K.; Lincoln D.; Linnemann J.; Lipaev V. V.; Lipton R.; Liu Y.; Lobodenko A.; Lokajicek M.; de Sa R. Lopes; Lubatti H. J.; Luna-Garcia R.; Lyon A. L.; Maciel A. K. A.; Mackin D.; Madar R.; Magana-Villalba R.; Malik S.; Malyshev V. L.; Maravin Y.; Martinez-Ortega J.; McCarthy R.; McGivern C. L.; Meijer M. M.; Melnitchouk A.; Menezes D.; Mercadante P. G.; Merkin M.; et al.

    2012-05-04

    We present an improved determination of the total width of the top quark, {Gamma}{sub t}, using 5.4 fb{sup -1} of integrated luminosity collected by the D0 Collaboration at the Tevatron p{bar p} Collider. The total width {Gamma}{sub t} is extracted from the partial decay width {Gamma}(t {yields} Wb) and the branching fraction {Beta}(t {yields} Wb). {Gamma}(t {yields} Wb) is obtained from the t-channel single top-quark production cross section and {Beta}(t {yields} Wb) is measured in t{bar t} events. For a top mass of 172.5 GeV, the resulting width is {Gamma}{sub t} = 2.00{sub -0.43}{sup +0.47} GeV. This translates to a top-quark lifetime of {tau}{sub t} = (3.29{sub -0.63}{sup +0.90}) x 10{sup -25} s. We also extract an improved direct limit on the Cabibbo-Kobayashi-Maskawa quark-mixing matrix element 0.81 < |V{sub tb}| {le} 1 at 95% C.L. and a limit of |V{sub tb}| < 0.59 for a high-mass fourth-generation bottom quark assuming unitarity of the fourth-generation quark-mixing matrix.

  14. Measurement of joint space width and erosion size

    NARCIS (Netherlands)

    Sharp, JI; van der Heijde, D; Angwin, J; Duryea, J; Moens, HJB; Jacobs, JWG; Maillefert, JF; Strand, CV

    2005-01-01

    Measurement of radiographic abnormalities in metric units has been reported by several investigators during the last 15 years. Measurement of joint space in large joints has been employed in a few trials to evaluate therapy in osteoarthritis. Measurement of joint space width in small joints has been

  15. Measurement of the current distribution in a direct methanol fuel cell-Confirmation of parallel galvanic and electrolytic operation within one cell

    Science.gov (United States)

    Sauer, Dirk Uwe; Sanders, Tilman; Fricke, Birger; Baumhöfer, Thorsten; Wippermann, Klaus; Kulikovsky, Andrei A.; Schmitz, Heinz; Mergel, Jürgen

    Current production in fuel cells is typically unequally distributed along the cell surface due to inhomogeneous concentration of reactants and temperature. The inhomogeneities in fuel cells can result in reduced output power and accelerated ageing. To quantify the inhomogeneities a measurement system has been developed which allows measuring the local distribution of current and temperature in hydrogen and direct methanol fuel cells. With this system we are able to directly observe the coexistence of galvanic and electrolytic domains in a single channel direct methanol fuel cell (the electrolytic domain is the domain where electrolysis occurs in contrast to the galvanic domain where the fuel cell process takes place). The measurement device also allows for the measurement locally resolved impedance spectra.

  16. Distribution of endocrine cells in the digestive tract of Alligator sinensis during the active and hibernating period.

    Science.gov (United States)

    Wang, Huan; Zhang, Shengzhou; Zhou, Naizhen; Wang, Chaolin; Wu, Xiaobing

    2014-10-01

    The digestive tract is the largest endocrine organ in the body; the distribution pattern of endocrine cells varies with different pathological and physiological states. The aim of the present study was to investigate the distributed density of 5-hydroxytryptamine (5-HT), gastrin (GAS), somatostatin (SS) and vasoactive intestinal peptide (VIP) immunoreactive (IR) cells in the digestive tract of Alligator sinensis during the active and hibernating period by immunohistochemical (IHC) method. The results indicated that 5-HT-IR cells were distributed throughout the entire digestive tract, which were most predominant in duodenum and jejunum. The density increased significantly in stomach and duodenum during hibernation. GAS-IR cells were limited in small stomach and small intestine. The density decreased significantly in small stomach during hibernation, while increased in duodenum. What's more, most of the endocrine cells in duodenum were generally spindle shaped with long cytoplasmic processes ending in the lumen during hibernation. SS-IR cells were limited in stomach and small stomach. The density increased in stomach while decreased in small stomach during hibernation, meanwhile, fewer IR cells occurred in small intestine. VIP-IR cells occurred in stomach and small stomach. The density decreased in small stomach, while increased in stomach during hibernation. These results indicated that the endocrine cells in different parts of digestive tract varied differently during hibernation, their changes were adaptive response to the hibernation.

  17. Lithologic controls on valley width and strath terrace formation

    Science.gov (United States)

    Schanz, Sarah A.; Montgomery, David R.

    2016-04-01

    Valley width and the degree of bedrock river terrace development vary with lithology in the Willapa and Nehalem river basins, Pacific Northwest, USA. Here, we present field-based evidence for the mechanisms by which lithology controls floodplain width and bedrock terrace formation in erosion-resistant and easily friable lithologies. We mapped valley surfaces in both basins, dated straths using radiocarbon, compared valley width versus drainage area for basalt and sedimentary bedrock valleys, and constructed slope-area plots. In the friable sedimentary bedrock, valleys are 2 to 3 times wider, host flights of strath terraces, and have concavity values near 1; whereas the erosion-resistant basalt bedrock forms narrow valleys with poorly developed, localized, or no bedrock terraces and a channel steepness index half that of the friable bedrock and an average channel concavity of about 0.5. The oldest dated strath terrace on the Willapa River, T2, was active for nearly 10,000 years, from 11,265 to 2862 calibrated years before present (cal YBP), whereas the youngest terrace, T1, is Anthropocene in age and recently abandoned. Incision rates derived from terrace ages average 0.32 mm y- 1 for T2 and 11.47 mm y- 1 for T1. Our results indicate bedrock weathering properties influence valley width through the creation of a dense fracture network in the friable bedrock that results in high rates of lateral erosion of exposed bedrock banks. Conversely, the erosion-resistant bedrock has concavity values more typical of detachment-limited streams, exhibits a sparse fracture network, and displays evidence for infrequent episodic block erosion and plucking. Lithology thereby plays a direct role on the rates of lateral erosion, influencing valley width and the potential for strath terrace planation and preservation.

  18. Distribution of cells labelled by a novel somatic stem cell-recognizing antibody (A3) in pulmonary genesis and bleomycin induced pulmonary fibrosis in rats.

    Science.gov (United States)

    Hori, M; Juniantito, V; Izawa, T; Ichikawa, C; Tanaka, M; Tanaka, K; Takenaka, S; Kuwamura, M; Yamate, J

    2013-05-01

    Stem cells play important roles in organogenesis and remodelling after tissue injury. A monoclonal antibody (A3) has been produced against rat somatic stem cells. The present study investigated the distribution of cells labelled by A3 in the lung of fetal, neonatal and adult rats, as well as in the lung of rats with bleomycin (BLM) induced pulmonary fibrosis. In developing fetal lungs, A3(+) interstitial cells were present around the bronchi/bronchioles and arterioles, while in neonatal and adult lungs, the A3 reactivity of the interstitial cells gradually disappeared and instead, vascular endothelial cells in alveolar capillaries and arterioles expressed A3. By double immunofluorescence labelling, the A3(+) interstitial cells also expressed vimentin (a mesenchymal marker) and CD34 (a marker of immature mesenchymal cells), indicating that the interstitial cells were immature mesenchymal cells concentrated in organs as precursors to cells of connective tissues. A3(+)endothelial cells were co-expressed RECA-1 (a marker of rat endothelial cells) and A3 was localized to the cell membrane and cytoplasm of these cells by immunoelectron microscopy. In BLM induced fibrotic lesions, there were many A3(+) cells, which also expressed vimentin or RECA-1 by dual immunofluorescence labelling. There were few CD34(+)/A3(+) double positive cells. No cells co-expressed A3 and α-smooth muscle actin (a marker of well-differentiated myofibroblastic cells). Although the detailed properties of cells labelled by A3 remain to be discovered, A3 would appear to be a useful marker of immature mesenchymal cells and vascular endothelial cells in developing lungs and in pulmonary fibrosis.

  19. Distributed generation system with PEM fuel cell for electrical power quality improvement

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez, D.; Beites, L.F.; Blazquez, F. [Department of Electrical Engineering, ETSII, Escuela de Ingenieros Industriales, Universidad Politecnica de Madrid, C/ Jose Gutierrez Abascal 2, 28006 Madrid (Spain); Ballesteros, J.C. [Endesa Generacion, S.A. c/ Ribera de Loira 60, 28042 Madrid (Spain)

    2008-08-15

    In this paper, a physical model for a distributed generation (DG) system with power quality improvement capability is presented. The generating system consists of a 5 kW PEM fuel cell, a natural gas reformer, hydrogen storage bottles and a bank of ultra-capacitors. Additional power quality functions are implemented with a vector-controlled electronic converter for regulating the injected power. The capabilities of the system were experimentally tested on a scaled electrical network. It is composed of different lines, built with linear inductances and resistances, and taking into account both linear and non-linear loads. The ability to improve power quality was tested by means of different voltage and frequency perturbations produced on the physical model electrical network. (author)

  20. A Direct Measurement of the Total Decay Width of the Top Quark

    CERN Document Server

    Aaltonen, Timo Antero; Amidei, Dante E; Anastassov, Anton Iankov; Annovi, Alberto; Antos, Jaroslav; Apollinari, Giorgio; Appel, Jeffrey A; Arisawa, Tetsuo; Artikov, Akram Muzafarovich; Asaadi, Jonathan A; Ashmanskas, William Joseph; Auerbach, Benjamin; Aurisano, Adam J; Azfar, Farrukh A; Badgett, William Farris; Bae, Taegil; Barbaro-Galtieri, Angela; Barnes, Virgil E; Barnett, Bruce Arnold; Barria, Patrizia; Bartos, Pavol; Bauce, Matteo; Bedeschi, Franco; Behari, Satyajit; Bellettini, Giorgio; Bellinger, James Nugent; Benjamin, Douglas P; Beretvas, Andrew F; Bhatti, Anwar Ahmad; Bland, Karen Renee; Blumenfeld, Barry J; Bocci, Andrea; Bodek, Arie; Bortoletto, Daniela; Boudreau, Joseph Francis; Boveia, Antonio; Brigliadori, Luca; Bromberg, Carl Michael; Brucken, Erik; Budagov, Ioulian A; Budd, Howard Scott; Burkett, Kevin Alan; Busetto, Giovanni; Bussey, Peter John; Butti, Pierfrancesco; Buzatu, Adrian; Calamba, Aristotle; Camarda, Stefano; Campanelli, Mario; Canelli, Florencia; Carls, Benjamin; Carlsmith, Duncan L; Carosi, Roberto; Carrillo Moreno, Salvador; Casal Larana, Bruno; Casarsa, Massimo; Castro, Andrea; Catastini, Pierluigi; Cauz, Diego; Cavaliere, Viviana; Cavalli-Sforza, Matteo; Cerri, Alessandro; Cerrito, Lucio; Chen, Yen-Chu; Chertok, Maxwell Benjamin; Chiarelli, Giorgio; Chlachidze, Gouram; Cho, Kihyeon; Chokheli, Davit; Clark, Allan Geoffrey; Clarke, Christopher Joseph; Convery, Mary Elizabeth; Conway, John Stephen; Corbo, Matteo; Cordelli, Marco; Cox, Charles Alexander; Cox, David Jeremy; Cremonesi, Matteo; Cruz Alonso, Daniel; Cuevas Maestro, Javier; Culbertson, Raymond Lloyd; D'Ascenzo, Nicola; Datta, Mousumi; de Barbaro, Pawel; Demortier, Luc M; Marchese, Luigi Marchese; Deninno, Maria Maddalena; Devoto, Francesco; D'Errico, Maria; Di Canto, Angelo; Di Ruzza, Benedetto; Dittmann, Jay Richard; D'Onofrio, Monica; Donati, Simone; Dorigo, Mirco; Driutti, Anna; Ebina, Koji; Edgar, Ryan Christopher; Elagin, Andrey L; Erbacher, Robin D; Errede, Steven Michael; Esham, Benjamin; Farrington, Sinead Marie; Fernández Ramos, Juan Pablo; Field, Richard D; Flanagan, Gene U; Forrest, Robert David; Franklin, Melissa EB; Freeman, John Christian; Frisch, Henry J; Funakoshi, Yujiro; Galloni, Camilla; Garfinkel, Arthur F; Garosi, Paola; Gerberich, Heather Kay; Gerchtein, Elena A; Giagu, Stefano; Giakoumopoulou, Viktoria Athina; Gibson, Karen Ruth; Ginsburg, Camille Marie; Giokaris, Nikos D; Giromini, Paolo; Giurgiu, Gavril A; Glagolev, Vladimir; Glenzinski, Douglas Andrew; Gold, Michael S; Goldin, Daniel; Golossanov, Alexander; Gomez, Gervasio; Gomez-Ceballos, Guillelmo; Goncharov, Maxim T; González López, Oscar; Gorelov, Igor V; Goshaw, Alfred T; Goulianos, Konstantin A; Gramellini, Elena; Grinstein, Sebastian; Grosso-Pilcher, Carla; Group, Robert Craig; Barreiro Guimaraes da Costa, Joao; Hahn, Stephen R; Han, Ji-Yeon; Happacher, Fabio; Hara, Kazuhiko; Hare, Matthew Frederick; Harr, Robert Francis; Harrington-Taber, Timothy; Hatakeyama, Kenichi; Hays, Christopher Paul; Heinrich, Joel G; Herndon, Matthew Fairbanks; Hocker, James Andrew; Hong, Ziqing; Hopkins, Walter Howard; Hou, Suen Ray; Hughes, Richard Edward; Husemann, Ulrich; Hussein, Mohammad; Huston, Joey Walter; Introzzi, Gianluca; Iori, Maurizio; Ivanov, Andrew Gennadievich; James, Eric B; Jang, Dongwook; Jayatilaka, Bodhitha Anjalike; Jeon, Eun-Ju; Jindariani, Sergo Robert; Jones, Matthew T; Joo, Kyung Kwang; Jun, Soon Yung; Junk, Thomas R; Kambeitz, Manuel; Kamon, Teruki; Karchin, Paul Edmund; Kasmi, Azeddine; Kato, Yukihiro; Ketchum, Wesley Robert; Keung, Justin Kien; Kilminster, Benjamin John; Kim, DongHee; Kim, Hyunsoo; Kim, Jieun; Kim, Min Jeong; Kim, Soo Bong; Kim, Shin-Hong; Kim, Young-Kee; Kim, Young-Jin; Kimura, Naoki; Kirby, Michael H; Knoepfel, Kyle James; Kondo, Kunitaka; Kong, Dae Jung; Konigsberg, Jacobo; Kotwal, Ashutosh Vijay; Kreps, Michal; Kroll, IJoseph; Kruse, Mark Charles; Kuhr, Thomas; Kurata, Masakazu; Laasanen, Alvin Toivo; Lammel, Stephan; Lancaster, Mark; Lannon, Kevin Patrick; Latino, Giuseppe; Lee, Hyun Su; Lee, Jaison; Leo, Sabato; Leone, Sandra; Lewis, Jonathan D; Limosani, Antonio; Lipeles, Elliot David; Lister, Alison; Liu, Hao; Liu, Qiuguang; Liu, Tiehui Ted; Lockwitz, Sarah E; Loginov, Andrey Borisovich; Lucà, Alessandra; Lucchesi, Donatella; Lueck, Jan; Lujan, Paul Joseph; Lukens, Patrick Thomas; Lungu, Gheorghe; Lys, Jeremy E; Lysak, Roman; Madrak, Robyn Leigh; Maestro, Paolo; Malik, Sarah Alam; Manca, Giulia; Manousakis-Katsikakis, Arkadios; Margaroli, Fabrizio; Marino, Christopher Phillip; Martínez-Perez, Mario; Matera, Keith; Mattson, Mark Edward; Mazzacane, Anna; Mazzanti, Paolo; McNulty, Ronan; Mehta, Andrew; Mehtala, Petteri; Mesropian, Christina; Miao, Ting; Mietlicki, David John; Mitra, Ankush; Miyake, Hideki; Moed, Shulamit; Moggi, Niccolo; Moon, Chang-Seong; Moore, Ronald Scott; Morello, Michael Joseph; Mukherjee, Aseet; Muller, Thomas; Murat, Pavel A; Mussini, Manuel; Nachtman, Jane Marie; Nagai, Yoshikazu; Naganoma, Junji; Nakano, Itsuo; Napier, Austin; Nett, Jason Michael; Neu, Christopher Carl; Nigmanov, Turgun S; Nodulman, Lawrence J; Noh, Seoyoung; Norniella Francisco, Olga; Oakes, Louise Beth; Oh, Seog Hwan; Oh, Young-do; Oksuzian, Iuri Artur; Okusawa, Toru; Orava, Risto Olavi; Ortolan, Lorenzo; Pagliarone, Carmine Elvezio; Palencia, Jose Enrique; Palni, Prabhakar; Papadimitriou, Vaia; Parker, William Chesluk; Pauletta, Giovanni; Paulini, Manfred; Paus, Christoph Maria Ernst; Phillips, Thomas J; Piacentino, Giovanni M; Pianori, Elisabetta; Pilot, Justin Robert; Pitts, Kevin T; Plager, Charles; Pondrom, Lee G; Poprocki, Stephen; Potamianos, Karolos Jozef; Prokoshin, Fedor; Pranko, Aliaksandr Pavlovich; Ptohos, Fotios K; Punzi, Giovanni; Ranjan, Niharika; Redondo Fernández, Ignacio; Renton, Peter B; Rescigno, Marco; Rimondi, Franco; Ristori, Luciano; Robson, Aidan; Rodriguez, Tatiana Isabel; Rolli, Simona; Ronzani, Manfredi; Roser, Robert Martin; Rosner, Jonathan L; Ruffini, Fabrizio; Ruiz Jimeno, Alberto; Russ, James S; Rusu, Vadim Liviu; Sakumoto, Willis Kazuo; Sakurai, Yuki; Santi, Lorenzo; Sato, Koji; Saveliev, Valeri; Savoy-Navarro, Aurore; Schlabach, Philip; Schmidt, Eugene E; Schwarz, Thomas A; Scodellaro, Luca; Scuri, Fabrizio; Seidel, Sally C; Seiya, Yoshihiro; Semenov, Alexei; Sforza, Federico; Shalhout, Shalhout Zaki; Shears, Tara G; Shepard, Paul F; Shimojima, Makoto; Shochet, Melvyn J; Tecker-Shreyber, Irina; Simonenko, Alexander V; Sliwa, Krzysztof Jan; Smith, John Rodgers; Snider, Frederick Douglas; Sorin, Maria Veronica; Song, Hao; Stancari, Michelle Dawn; St Denis, Richard Dante; Stentz, Dale James; Strologas, John; Sudo, Yuji; Sukhanov, Alexander I; Suslov, Igor M; Takemasa, Ken-ichi; Takeuchi, Yuji; Tang, Jian; Tecchio, Monica; Teng, Ping-Kun; Thom, Julia; Thomson, Evelyn Jean; Thukral, Vaikunth; Toback, David A; Tokar, Stanislav; Tollefson, Kirsten Anne; Tomura, Tomonobu; Tonelli, Diego; Torre, Stefano; Torretta, Donatella; Totaro, Pierluigi; Trovato, Marco; Ukegawa, Fumihiko; Uozumi, Satoru; Vázquez-Valencia, Elsa Fabiola; Velev, Gueorgui; Vellidis, Konstantinos; Vernieri, Caterina; Vidal Marono, Miguel; Vilar Cortabitarte, Rocio; Vizán Garcia, Jesus Manuel; Vogel, Marcelo; Volpi, Guido; Wagner, Peter; Wallny, Rainer S; Wang, Song-Ming; Waters, David S; Wester, William Carl; Whiteson, Daniel O; Wicklund, Arthur Barry; Wilbur, Scott; Williams, Hugh H; Wilson, Jonathan Samuel; Wilson, Peter James; Winer, Brian L; Wittich, Peter; Wolbers, Stephen A; Wolfe, Homer; Wright, Thomas Roland; Wu, Xin; Wu, Zhenbin; Yamamoto, Kazuhiro; Yamato, Daisuke; Yang, Tingjun; Yang, Un-Ki; Yang, Yu Chul; Yao, Wei-Ming; Yeh, Gong Ping; Yi, Kai; Yoh, John; Yorita, Kohei; Yoshida, Takuo; Yu, Geum Bong; Yu, Intae; Zanetti, Anna Maria; Zeng, Yu; Zhou, Chen; Zucchelli, Stefano

    2013-01-01

    We present a measurement of the total decay width of the top quark using events with top-antitop-quark pair candidates reconstructed in the final state with one charged lepton and four or more hadronic jets. We use the full Tevatron Run~II data set of $\\sqrt{s} = 1.96$~TeV proton-antiproton collisions recorded by the CDF II detector. The top-quark mass and the mass of the hadronically-decaying $W$ boson are reconstructed for each event and compared with distributions derived from simulated signal and background samples to extract the top-quark width (\\gmt) and the energy scale of the calorimeter jets with {\\it in-situ} calibration. For a top-quark mass $\\mtop = \\gevcc{172.5}$, we find $1.10<\\gmt<\\gev{4.05}$ at 68\\% confidence level, which is in agreement with the standard-model expectation of \\gev{1.3} and is the most precise direct measurement of the top-quark width to date.

  1. Direct Measurement of the Total Decay Width of the Top Quark

    Science.gov (United States)

    Aaltonen, T.; Amerio, S.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Apollinari, G.; Appel, J. A.; Arisawa, T.; Artikov, A.; Asaadi, J.; Ashmanskas, W.; Auerbach, B.; Aurisano, A.; Azfar, F.; Badgett, W.; Bae, T.; Barbaro-Galtieri, A.; Barnes, V. E.; Barnett, B. A.; Barria, P.; Bartos, P.; Bauce, M.; Bedeschi, F.; Behari, S.; Bellettini, G.; Bellinger, J.; Benjamin, D.; Beretvas, A.; Bhatti, A.; Bland, K. R.; Blumenfeld, B.; Bocci, A.; Bodek, A.; Bortoletto, D.; Boudreau, J.; Boveia, A.; Brigliadori, L.; Bromberg, C.; Brucken, E.; Budagov, J.; Budd, H. S.; Burkett, K.; Busetto, G.; Bussey, P.; Butti, P.; Buzatu, A.; Calamba, A.; Camarda, S.; Campanelli, M.; Canelli, F.; Carls, B.; Carlsmith, D.; Carosi, R.; Carrillo, S.; Casal, B.; Casarsa, M.; Castro, A.; Catastini, P.; Cauz, D.; Cavaliere, V.; Cavalli-Sforza, M.; Cerri, A.; Cerrito, L.; Chen, Y. C.; Chertok, M.; Chiarelli, G.; Chlachidze, G.; Cho, K.; Chokheli, D.; Clark, A.; Clarke, C.; Convery, M. E.; Conway, J.; Corbo, M.; Cordelli, M.; Cox, C. A.; Cox, D. J.; Cremonesi, M.; Cruz, D.; Cuevas, J.; Culbertson, R.; d'Ascenzo, N.; Datta, M.; de Barbaro, P.; Demortier, L.; Deninno, M.; D'Errico, M.; Devoto, F.; Di Canto, A.; Di Ruzza, B.; Dittmann, J. R.; Donati, S.; D'Onofrio, M.; Dorigo, M.; Driutti, A.; Ebina, K.; Edgar, R.; Elagin, A.; Erbacher, R.; Errede, S.; Esham, B.; Farrington, S.; Fernández Ramos, J. P.; Field, R.; Flanagan, G.; Forrest, R.; Franklin, M.; Freeman, J. C.; Frisch, H.; Funakoshi, Y.; Galloni, C.; Garfinkel, A. F.; Garosi, P.; Gerberich, H.; Gerchtein, E.; Giagu, S.; Giakoumopoulou, V.; Gibson, K.; Ginsburg, C. M.; Giokaris, N.; Giromini, P.; Giurgiu, G.; Glagolev, V.; Glenzinski, D.; Gold, M.; Goldin, D.; Golossanov, A.; Gomez, G.; Gomez-Ceballos, G.; Goncharov, M.; González López, O.; Gorelov, I.; Goshaw, A. T.; Goulianos, K.; Gramellini, E.; Grinstein, S.; Grosso-Pilcher, C.; Group, R. C.; Guimaraes da Costa, J.; Hahn, S. R.; Han, J. Y.; Happacher, F.; Hara, K.; Hare, M.; Harr, R. F.; Harrington-Taber, T.; Hatakeyama, K.; Hays, C.; Heinrich, J.; Herndon, M.; Hocker, A.; Hong, Z.; Hopkins, W.; Hou, S.; Hughes, R. E.; Husemann, U.; Hussein, M.; Huston, J.; Introzzi, G.; Iori, M.; Ivanov, A.; James, E.; Jang, D.; Jayatilaka, B.; Jeon, E. J.; Jindariani, S.; Jones, M.; Joo, K. K.; Jun, S. Y.; Junk, T. R.; Kambeitz, M.; Kamon, T.; Karchin, P. E.; Kasmi, A.; Kato, Y.; Ketchum, W.; Keung, J.; Kilminster, B.; Kim, D. H.; Kim, H. S.; Kim, J. E.; Kim, M. J.; Kim, S. H.; Kim, S. B.; Kim, Y. J.; Kim, Y. K.; Kimura, N.; Kirby, M.; Knoepfel, K.; Kondo, K.; Kong, D. J.; Konigsberg, J.; Kotwal, A. V.; Kreps, M.; Kroll, J.; Kruse, M.; Kuhr, T.; Kurata, M.; Laasanen, A. T.; Lammel, S.; Lancaster, M.; Lannon, K.; Latino, G.; Lee, H. S.; Lee, J. S.; Leo, S.; Leone, S.; Lewis, J. D.; Limosani, A.; Lipeles, E.; Lister, A.; Liu, H.; Liu, Q.; Liu, T.; Lockwitz, S.; Loginov, A.; Lucchesi, D.; Lucà, A.; Lueck, J.; Lujan, P.; Lukens, P.; Lungu, G.; Lys, J.; Lysak, R.; Madrak, R.; Maestro, P.; Malik, S.; Manca, G.; Manousakis-Katsikakis, A.; Marchese, L.; Margaroli, F.; Marino, P.; Martínez, M.; Matera, K.; Mattson, M. E.; Mazzacane, A.; Mazzanti, P.; McNulty, R.; Mehta, A.; Mehtala, P.; Mesropian, C.; Miao, T.; Mietlicki, D.; Mitra, A.; Miyake, H.; Moed, S.; Moggi, N.; Moon, C. S.; Moore, R.; Morello, M. J.; Mukherjee, A.; Muller, Th.; Murat, P.; Mussini, M.; Nachtman, J.; Nagai, Y.; Naganoma, J.; Nakano, I.; Napier, A.; Nett, J.; Neu, C.; Nigmanov, T.; Nodulman, L.; Noh, S. Y.; Norniella, O.; Oakes, L.; Oh, S. H.; Oh, Y. D.; Oksuzian, I.; Okusawa, T.; Orava, R.; Ortolan, L.; Pagliarone, C.; Palencia, E.; Palni, P.; Papadimitriou, V.; Parker, W.; Pauletta, G.; Paulini, M.; Paus, C.; Phillips, T. J.; Piacentino, G.; Pianori, E.; Pilot, J.; Pitts, K.; Plager, C.; Pondrom, L.; Poprocki, S.; Potamianos, K.; Pranko, A.; Prokoshin, F.; Ptohos, F.; Punzi, G.; Ranjan, N.; Redondo Fernández, I.; Renton, P.; Rescigno, M.; Rimondi, F.; Ristori, L.; Robson, A.; Rodriguez, T.; Rolli, S.; Ronzani, M.; Roser, R.; Rosner, J. L.; Ruffini, F.; Ruiz, A.; Russ, J.; Rusu, V.; Sakumoto, W. K.; Sakurai, Y.; Santi, L.; Sato, K.; Saveliev, V.; Savoy-Navarro, A.; Schlabach, P.; Schmidt, E. E.; Schwarz, T.; Scodellaro, L.; Scuri, F.; Seidel, S.; Seiya, Y.; Semenov, A.; Sforza, F.; Shalhout, S. Z.; Shears, T.; Shepard, P. F.; Shimojima, M.; Shochet, M.; Shreyber-Tecker, I.; Simonenko, A.; Sliwa, K.; Smith, J. R.; Snider, F. D.; Song, H.; Sorin, V.; St. Denis, R.; Stancari, M.; Stentz, D.; Strologas, J.; Sudo, Y.; Sukhanov, A.; Suslov, I.; Takemasa, K.; Takeuchi, Y.; Tang, J.; Tecchio, M.; Teng, P. K.; Thom, J.; Thomson, E.; Thukral, V.; Toback, D.; Tokar, S.; Tollefson, K.; Tomura, T.; Tonelli, D.; Torre, S.; Torretta, D.; Totaro, P.; Trovato, M.; Ukegawa, F.; Uozumi, S.; Vázquez, F.; Velev, G.; Vellidis, C.; Vernieri, C.; Vidal, M.; Vilar, R.; Vizán, J.; Vogel, M.; Volpi, G.; Wagner, P.; Wallny, R.; Wang, S. M.; Waters, D.; Wester, W. C., III; Whiteson, D.; Wicklund, A. B.; Wilbur, S.; Williams, H. H.; Wilson, J. S.; Wilson, P.; Winer, B. L.; Wittich, P.; Wolbers, S.; Wolfe, H.; Wright, T.; Wu, X.; Wu, Z.; Yamamoto, K.; Yamato, D.; Yang, T.; Yang, U. K.; Yang, Y. C.; Yao, W.-M.; Yeh, G. P.; Yi, K.; Yoh, J.; Yorita, K.; Yoshida, T.; Yu, G. B.; Yu, I.; Zanetti, A. M.; Zeng, Y.; Zhou, C.; Zucchelli, S.

    2013-11-01

    We present a measurement of the total decay width of the top quark using events with top-antitop quark pair candidates reconstructed in the final state with one charged lepton and four or more hadronic jets. We use the full Tevatron run II data set of s=1.96TeV proton-antiproton collisions recorded by the CDF II detector. The top quark mass and the mass of the hadronically decaying W boson are reconstructed for each event and compared with distributions derived from simulated signal and background samples to extract the top quark width (Γtop) and the energy scale of the calorimeter jets with in situ calibration. For a top quark mass Mtop=172.5GeV/c2, we find 1.10<Γtop<4.05GeV at 68% confidence level, which is in agreement with the standard model expectation of 1.3 GeV and is the most precise direct measurement of the top quark width to date.

  2. Finite-width effects in unstable-particle production at hadron colliders

    Energy Technology Data Exchange (ETDEWEB)

    Falgari, P. [Utrecht Univ. (Netherlands). Inst. for Theoretical Physics; Utrecht Univ. (Netherlands). Spinoza Inst.; Papanastasiou, A.S. [Deutsches Elektronen-Synchrotron DESY, Hamburg (Germany); Signer, A. [Paul Scherrer Institut, Villigen (Switzerland); Zuerich Univ. (Switzerland). Inst. for Theoretical Physics

    2013-03-15

    We present a general formalism for the calculation of finite-width contributions to the differential production cross sections of unstable particles at hadron colliders. In this formalism, which employs an effective-theory description of unstable-particle production and decay, the matrix element computation is organized as a gauge-invariant expansion in powers of {Gamma}{sub X}/m{sub X}, with {Gamma}{sub X} and m{sub X} the width and mass of the unstable particle. This framework allows for a systematic inclusion of off-shell and non-factorizable effects whilst at the same time keeping the computational effort minimal compared to a full calculation in the complex-mass scheme. As a proof-of-concept example, we give results for an NLO calculation of top-antitop production in the q anti q partonic channel. As already found in a similar calculation of single-top production, the finite-width effects are small for the total cross section, as expected from the naive counting {proportional_to}{Gamma}{sub t}/m{sub t}{proportional_to}1%. However, they can be sizeable, in excess of 10%, close to edges of certain kinematical distributions. The dependence of the results on the mass renormalization scheme, and its implication for a precise extraction of the top-quark mass, is also discussed.

  3. Dynamic Voltage Restorer Based on Space Vector Pulse Width Modulation Technique

    Directory of Open Access Journals (Sweden)

    B.N S P Venkatesh

    2011-07-01

    Full Text Available Power Quality problems encompass a wide range of disturbances such as voltage sags, swells, flicker,harmonics distortion and interruptions. The strategic deployment of custom power devices has been proposed asone of the means to protect sensitive loads from power quality problems such as voltage sags and swells. The Dynamic Voltage Restorer (DVR is a power electronic device that is used to inject 3-phase voltage in series and in synchronism with the distribution feeder voltages in order to compensate voltage sag and similarly itreacts quickly to inject the appropriate voltage component (negative voltage magnitude in order to compensate voltage swell. The principal component of the DVR is a voltage source inverter that generates three phase voltages and provides the voltage support to a sensitive load during voltage sags and swells. Pulse Width Modulation Technique is very critical for proper control of DVR. Sinusoidal Pulse Width Modulation (SPWM and Space Vector Pulse Width Modulation (SVPWM control techniques are used for controlling the DVR. Inthis work, the operation of DVR is presented and the control technique used for voltage source inverter is Space Vector PWM technique. Space vector PWM can utilize the better dc voltage and generates the fewer harmonic in inverter output voltage than Sinusoidal PWM technique. This work describes the DVR based on Space Vector PWM which provides voltage support to sensitive loads and is simulated by using MATLAB/SIMULINK. Simulation results show that the control approach is able to compensate for any type of voltage sags and swells.

  4. Modeling and control of hybrid wind/photovoltaic/fuel cell distributed generation systems

    Science.gov (United States)

    Wang, Caisheng

    Due to ever increasing energy consumption, rising public awareness of environmental protection, and steady progress in power deregulation, alternative (i.e., renewable and fuel cell based) distributed generation (DG) systems have attracted increased interest. Wind and photovoltaic (PV) power generation are two of the most promising renewable energy technologies. Fuel cell (FC) systems also show great potential in DG applications of the future due to their fast technology development and many merits they have, such as high efficiency, zero or low emission (of pollutant gases) and flexible modular structure. The modeling and control of a hybrid wind/PV/FC DG system is addressed in this dissertation. Different energy sources in the system are integrated through an AC bus. Dynamic models for the main system components, namely, wind energy conversion system (WECS), PV energy conversion system (PVECS), fuel cell, electrolyzer, power electronic interfacing circuits, battery, hydrogen storage tank, gas compressor and gas pressure regulator, are developed. Two types of fuel cells have been modeled in this dissertation: proton exchange membrane fuel cell (PEMFC) and solid oxide fuel cell (SOFC). Power control of a grid-connected FC system as well as load mitigation control of a stand-alone FC system are investigated. The pitch angle control for WECS, the maximum power point tracking (MPPT) control for PVECS, and the control for electrolyzer and power electronic devices, are also addressed in the dissertation. Based on the dynamic component models, a simulation model for the proposed hybrid energy system has been developed using MATLAB/Simulink. The overall power management strategy for coordinating the power flows among the different energy sources is presented in the dissertation. Simulation studies have been carried out to verify the system performance under different scenarios using a practical load profile and real weather data. The results show that the overall power

  5. The impact of capillary dilation on the distribution of red blood cells in artificial networks.

    Science.gov (United States)

    Schmid, Franca; Reichold, Johannes; Weber, Bruno; Jenny, Patrick

    2015-04-01

    Recent studies suggest that pericytes around capillaries are contractile and able to alter the diameter of capillaries. To investigate the effects of capillary dilation on network dynamics, we performed simulations in artificial capillary networks of different sizes and complexities. The unequal partition of hematocrit at diverging bifurcations was modeled by assuming that each red blood cell (RBC) enters the branch with the faster instantaneous flow. Network simulations with and without RBCs were performed to investigate the effect of local dilations. The results showed that the increase in flow rate due to capillary dilation was less when the effects of RBCs are included. For bifurcations with sufficient RBCs in the parent vessel and nearly equal flows in the branches, the flow rate in the dilated branch did not increase. Instead, a self-regulation of flow was observed due to accumulation of RBCs in the dilated capillary. A parametric study was performed to examine the dependence on initial capillary diameter, dilation factor, and tube hematocrit. Furthermore, the conditions needed for an efficient self-regulation mechanism are discussed. The results support the hypothesis that RBCs play a significant role for the fluid dynamics in capillary networks and that it is crucial to consider the blood flow rate and the distribution of RBCs to understand the supply of oxygen in the vasculature. Furthermore, our results suggest that capillary dilation/constriction offers the potential of being an efficient mechanism to alter the distribution of RBCs locally and hence could be important for the local regulation of oxygen delivery.

  6. Synchrotron-based analysis of chromium distributions in multicrystalline silicon for solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Mallory Ann; Hofstetter, Jasmin; Morishige, Ashley E.; Coletti, Gianluca; Lai, Barry; Fenning, David P.; Buonassisi, Tonio

    2015-05-18

    Chromium (Cr) can degrade silicon wafer-based solar cell efficiencies at concentrations as low as 10(10) cm(-3). In this contribution, we employ synchrotron-based X-ray fluorescence microscopy to study chromium distributions in multicrystalline silicon in as-grown material and after phosphorous diffusion. We complement quantified precipitate size and spatial distribution with interstitial Cr concentration and minority carrier lifetime measurements to provide insight into chromium gettering kinetics and offer suggestions for minimizing the device impacts of chromium. We observe that Cr-rich precipitates in as-grown material are generally smaller than iron-rich precipitates and that Cri point defects account for only one-half of the total Cr in the as-grown material. This observation is consistent with previous hypotheses that Cr transport and CrSi2 growth are more strongly diffusion-limited during ingot cooling. We apply two phosphorous diffusion gettering profiles that both increase minority carrier lifetime by two orders of magnitude and reduce [Cr-i] by three orders of magnitude to approximate to 10(10) cm(-3). Some Cr-rich precipitates persist after both processes, and locally high [Cri] after the high-temperature process indicates that further optimization of the chromium gettering profile is possible. (C) 2015 AIP Publishing LLC.

  7. Distribution of Interstitial Cells of Cajal in the Esophagus of Fetal Rats with Esophageal Atresia

    Directory of Open Access Journals (Sweden)

    Caner Isbir

    2016-04-01

    Full Text Available Aim: Scarcity of the interstitial cells of Cajal (ICC is related to motility disorders. In the study, we aimed to evaluate the number and density of ICCs in the fetal rat esophagus in the adriamycin - esophageal atresia (EA model. Material and Method: Rat fetuses were divided into three groups as a control, adriamycin group without EA and adriamycin group with EA. Four doses of adriamycin, 2 mg/kg each, were injected intraperitoneally to the adriamycin group rats between on 6 and 9 days of gestation. The presence of ICCs in the esophagus of the rat fetuses was determined by using an immunohistochemistry technique (c-kit, CD117. The average numbers of ICCs were calculated with microscopic evaluation by using a visual scoring system (range1 to 3. Results: Seven fetuses were included in each group. The ICCs score 3 distributions of fetuses were 5 (72% fetuses in the control group, 3 (43% fetuses in the adriamycin group without EA, 1 (14% fetus in the adriamycin group with EA. It have been found that there was a marked reduction of ICCs distribution in the adriamycin group with EA compared to control group (p 0.05. Discussion: ICCs density was significantly decreased in the rat fetuses with EA compared to the fetuses without EA. These findings support the idea that ICCs density may be congenitally abnormal in EA. This may be led to dismotility seen in the operated esophagus due to EA.

  8. Measurement of the W boson mass and width using a novel recoil model

    Energy Technology Data Exchange (ETDEWEB)

    Wetstein, Matthew J.

    2009-01-01