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Sample records for cd81 permits infection

  1. HIV-1 Entry and Trans-Infection of Astrocytes Involves CD81 Vesicles

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    Gray, Lachlan R.; Turville, Stuart G.; HItchen, Tina L.; Cheng, Wan-Jung; Ellett, Anne M.; Salimi, Hamid; Roche, Michael J.; Wesselingh, Steve L.; Gorry, Paul R.; Churchill, Melissa J.

    2014-01-01

    Astrocytes are extensively infected with HIV-1 in vivo and play a significant role in the development of HIV-1-associated neurocognitive disorders. Despite their extensive infection, little is known about how astrocytes become infected, since they lack cell surface CD4 expression. In the present study, we investigated the fate of HIV-1 upon infection of astrocytes. Astrocytes were found to bind and harbor virus followed by biphasic decay, with HIV-1 detectable out to 72 hours. HIV-1 was observed to associate with CD81-lined vesicle structures. shRNA silencing of CD81 resulted in less cell-associated virus but no loss of co-localization between HIV-1 and CD81. Astrocytes supported trans-infection of HIV-1 to T-cells without de novo virus production, and the virus-containing compartment required 37°C to form, and was trypsin-resistant. The CD81 compartment observed herein, has been shown in other cell types to be a relatively protective compartment. Within astrocytes, this compartment may be actively involved in virus entry and/or spread. The ability of astrocytes to transfer virus, without de novo viral synthesis suggests they are capable of sequestering and protecting virus and thus, they could potentially facilitate viral dissemination in the CNS. PMID:24587404

  2. CD81 is a central regulator of cellular events required for hepatitis C virus infection of human hepatocytes.

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    Brazzoli, Michela; Bianchi, Alessia; Filippini, Sara; Weiner, Amy; Zhu, Qing; Pizza, Mariagrazia; Crotta, Stefania

    2008-09-01

    Infection with hepatitis C virus (HCV) is still a major public health problem, and the events leading to hepatocyte infection are not yet fully understood. Combining confocal microscopy with biochemical analysis and studies of infection requirements using pharmacological inhibitors and small interfering RNAs, we show here that engagement of CD81 activates the Rho GTPase family members Rac, Rho, and Cdc42 and that the block of these signaling pathways drastically reduces HCV infectivity. Activation of Rho GTPases mediates actin-dependent relocalization of the HCV E2/CD81 complex to cell-cell contact areas where CD81 comes into contact with the tight-junction proteins occludin, ZO-1, and claudin-1, which was recently described as an HCV coreceptor. Finally, we show that CD81 engagement activates the Raf/MEK/ERK signaling cascade and that this pathway affects postentry events of the virus life cycle. In conclusion, we describe a range of cellular events that are manipulated by HCV to coordinate interactions with its multiple coreceptors and to establish productive infections and find that CD81 is a central regulator of these events.

  3. CD81 Is a Central Regulator of Cellular Events Required for Hepatitis C Virus Infection of Human Hepatocytes▿ †

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    Brazzoli, Michela; Bianchi, Alessia; Filippini, Sara; Weiner, Amy; Zhu, Qing; Pizza, Mariagrazia; Crotta, Stefania

    2008-01-01

    Infection with hepatitis C virus (HCV) is still a major public health problem, and the events leading to hepatocyte infection are not yet fully understood. Combining confocal microscopy with biochemical analysis and studies of infection requirements using pharmacological inhibitors and small interfering RNAs, we show here that engagement of CD81 activates the Rho GTPase family members Rac, Rho, and Cdc42 and that the block of these signaling pathways drastically reduces HCV infectivity. Activ...

  4. Anti-CD81 but not anti-SR-BI blocks Plasmodium falciparum liver infection in a humanized mouse model

    NARCIS (Netherlands)

    Foquet, L.; Hermsen, C.C.; Verhoye, L.; Gemert, G.J.A. van; Cortese, R.; Nicosia, A.; Sauerwein, R.W.; Leroux-Roels, G.; Meuleman, P.

    2015-01-01

    OBJECTIVES: Plasmodium falciparum sporozoites, deposited in the skin by infected Anopheles mosquitoes taking a blood meal, cross the endothelium of skin capillaries and travel to the liver where they traverse Kupffer cells and hepatocytes to finally invade a small number of the latter. In

  5. Hepatoma polarization limits CD81 and hepatitis C virus dynamics.

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    Harris, H J; Clerte, C; Farquhar, M J; Goodall, M; Hu, K; Rassam, P; Dosset, P; Wilson, G K; Balfe, P; Ijzendoorn, S C; Milhiet, P E; McKeating, J A

    2013-03-01

    Many viruses target the polarized epithelial apex during host invasion. In contrast, hepatitis C virus (HCV) engages receptors at the basal surface of hepatocytes in the polarized liver parenchyma. Hepatocyte polarization limits HCV entry by undefined mechanism(s). Given the recent reports highlighting a role for receptor mobility in pathogen entry, we studied the effect(s) of hepatocyte polarization on viral receptor and HCV pseudoparticle (HCVpp) dynamics using real-time fluorescence recovery after photobleaching and single particle tracking. Hepatoma polarization reduced CD81 and HCVpp dynamics at the basal membrane. Since cell polarization is accompanied by changes in the actin cytoskeleton and CD81 links to actin via its C-terminus, we studied the dynamics of a mutant CD81 lacking a C-terminal tail (CD81(ΔC)) and its effect(s) on HCVpp mobility and infection. CD81(ΔC) showed an increased frequency of confined trajectories and a reduction of Brownian diffusing molecules compared to wild-type protein in non-polarized cells. However, these changes were notobserved in polarized cells. HCVpp showed a significant reduction in Brownian diffusion and infection of CD81(ΔC) expressing non-polarized cells. In summary, these data highlight the dynamic nature of CD81 and demonstrate a role for CD81 lateral diffusion to regulate HCV infection in a polarization-dependent manner.

  6. Hepatitis C virus entry and the tetraspanin CD81.

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    Farquhar, Michelle J; Harris, Helen J; McKeating, Jane A

    2011-04-01

    CD81, a member of the tetraspanin integral membrane protein family, has been identified as an essential receptor for HCV (hepatitis C virus). The present review highlights recent published data on the role that CD81 plays in HCV entry, including the importance of actin-dependent lateral diffusion of CD81 within the cell membrane, CD81 endocytosis and the CD81-Claudin-1 receptor complex in HCV internalization. Additional functions for CD81 in the viral life cycle and the role of HCV-CD81 interactions in HCV-induced B-cell and CNS (central nervous system) abnormalities are discussed.

  7. Targeting CD81 to Prevent Metastases in Breast Cancer

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    2015-10-01

    lacking CD81 (4T1CD81KO): We used CRISPR -Cas9 methodology to knockout CD81 in 4T1 parental and 4T1-Luc cells, Figure 5 demonstrates complete lack of CD81...expression in these 4T1 tumors. Figure 5: Generation of 4T1 cell lines in which CD81 was knocked out by CRISPR -Cas9 methodology. Shown is CD81...that expressing exogenous CD81 in a human melanoma cell line enhanced its migrating, invasive and metastatic abilities in a xenograft model (27). This

  8. A Role for CD81 and Hepatitis C Virus in Hepatoma Mobility

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    Claire L. Brimacombe

    2014-03-01

    Full Text Available Tetraspanins are a family of small proteins that interact with themselves, host transmembrane and cytosolic proteins to form tetraspanin enriched microdomains (TEMs that regulate important cellular functions. Several tetraspanin family members are linked to tumorigenesis. Hepatocellular carcinoma (HCC is an increasing global health burden, in part due to the increasing prevalence of hepatitis C virus (HCV associated HCC. The tetraspanin CD81 is an essential receptor for HCV, however, its role in hepatoma biology is uncertain. We demonstrate that antibody engagement of CD81 promotes hepatoma spread, which is limited by HCV infection, in an actin-dependent manner and identify an essential role for the C-terminal interaction with Ezrin-Radixin-Moesin (ERM proteins in this process. We show enhanced hepatoma migration and invasion following expression of CD81 and a reduction in invasive potential upon CD81 silencing. In addition, we reveal poorly differentiated HCC express significantly higher levels of CD81 compared to adjacent non-tumor tissue. In summary, these data support a role for CD81 in regulating hepatoma mobility and propose CD81 as a tumour promoter.

  9. A role for CD81 and hepatitis C virus in hepatoma mobility.

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    Brimacombe, Claire L; Wilson, Garrick K; Hübscher, Stefan G; McKeating, Jane A; Farquhar, Michelle J

    2014-03-24

    Tetraspanins are a family of small proteins that interact with themselves, host transmembrane and cytosolic proteins to form tetraspanin enriched microdomains (TEMs) that regulate important cellular functions. Several tetraspanin family members are linked to tumorigenesis. Hepatocellular carcinoma (HCC) is an increasing global health burden, in part due to the increasing prevalence of hepatitis C virus (HCV) associated HCC. The tetraspanin CD81 is an essential receptor for HCV, however, its role in hepatoma biology is uncertain. We demonstrate that antibody engagement of CD81 promotes hepatoma spread, which is limited by HCV infection, in an actin-dependent manner and identify an essential role for the C-terminal interaction with Ezrin-Radixin-Moesin (ERM) proteins in this process. We show enhanced hepatoma migration and invasion following expression of CD81 and a reduction in invasive potential upon CD81 silencing. In addition, we reveal poorly differentiated HCC express significantly higher levels of CD81 compared to adjacent non-tumor tissue. In summary, these data support a role for CD81 in regulating hepatoma mobility and propose CD81 as a tumour promoter.

  10. Targeting CD81 to Prevent Metastases in Breast Cancer

    Science.gov (United States)

    2015-10-01

    AWARD NUMBER: W81XWH-14-1-0398 TITLE: Targeting CD81 to Prevent Metastases in Breast Cancer PRINCIPAL INVESTIGATOR: Dr. Stefanie Jeffrey...Targeting CD81 to Prevent Metastases in Breast Cancer 5b. GRANT NUMBER W81XWH-14-1-0398 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Stefanie Jeffrey 5d...SUPPLEMENTARY NOTES None 14. ABSTRACT During the research period, we tested a role for CD81 in breast cancer metastases and found that loss of CD81

  11. Inhibition of HCV 3a genotype entry through Host CD81 and HCV E2 antibodies

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    Ashfaq Usman A

    2011-11-01

    Full Text Available Abstract Background HCV causes acute and chronic hepatitis which can eventually lead to permanent liver damage hepatocellular carcinoma and death. HCV glycoproteins play an important role in HCV entry by binding with CD81 receptors. Hence inhibition of virus at entry step is an important target to identify antiviral drugs against HCV. Methods and result The present study elaborated the role of CD81 and HCV glycoprotein E2 in HCV entry using retroviral pseudo-particles of 3a local genotype. Our results demonstrated that HCV specific antibody E2 and host antibody CD81 showed dose- dependent inhibition of HCV entry. HCV E2 antibody showed 50% reduction at a concentration of 1.5 ± 1 μg while CD81 exhibited 50% reduction at a concentration of 0.8 ± 1 μg. In addition, data obtained with HCVpp were also confirmed with the infection of whole virus of HCV genotype 3a in liver cells. Conclusion Our data suggest that HCV specific E2 and host CD81 antibodies reduce HCVpp entry and full length viral particle and combination of host and HCV specific antibodies showed synergistic effect in reducing the viral titer.

  12. Active RNA replication of hepatitis C virus downregulates CD81 expression.

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    Ke, Po-Yuan; Chen, Steve S-L

    2013-01-01

    So far how hepatitis C virus (HCV) replication modulates subsequent virus growth and propagation still remains largely unknown. Here we determine the impact of HCV replication status on the consequential virus growth by comparing normal and high levels of HCV RNA expression. We first engineered a full-length, HCV genotype 2a JFH1 genome containing a blasticidin-resistant cassette inserted at amino acid residue of 420 in nonstructural (NS) protein 5A, which allowed selection of human hepatoma Huh7 cells stably-expressing HCV. Short-term establishment of HCV stable cells attained a highly-replicating status, judged by higher expressions of viral RNA and protein as well as higher titer of viral infectivity as opposed to cells harboring the same genome without selection. Interestingly, maintenance of highly-replicating HCV stable cells led to decreased susceptibility to HCV pseudotyped particle (HCVpp) infection and downregulated cell surface level of CD81, a critical HCV entry (co)receptor. The decreased CD81 cell surface expression occurred through reduced total expression and cytoplasmic retention of CD81 within an endoplasmic reticulum -associated compartment. Moreover, productive viral RNA replication in cells harboring a JFH1 subgenomic replicon containing a similar blasticidin resistance gene cassette in NS5A and in cells robustly replicating full-length infectious genome also reduced permissiveness to HCVpp infection through decreasing the surface expression of CD81. The downregulation of CD81 surface level in HCV RNA highly-replicating cells thus interfered with reinfection and led to attenuated viral amplification. These findings together indicate that the HCV RNA replication status plays a crucial determinant in HCV growth by modulating the expression and intracellular localization of CD81.

  13. Active RNA replication of hepatitis C virus downregulates CD81 expression.

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    Po-Yuan Ke

    Full Text Available So far how hepatitis C virus (HCV replication modulates subsequent virus growth and propagation still remains largely unknown. Here we determine the impact of HCV replication status on the consequential virus growth by comparing normal and high levels of HCV RNA expression. We first engineered a full-length, HCV genotype 2a JFH1 genome containing a blasticidin-resistant cassette inserted at amino acid residue of 420 in nonstructural (NS protein 5A, which allowed selection of human hepatoma Huh7 cells stably-expressing HCV. Short-term establishment of HCV stable cells attained a highly-replicating status, judged by higher expressions of viral RNA and protein as well as higher titer of viral infectivity as opposed to cells harboring the same genome without selection. Interestingly, maintenance of highly-replicating HCV stable cells led to decreased susceptibility to HCV pseudotyped particle (HCVpp infection and downregulated cell surface level of CD81, a critical HCV entry (coreceptor. The decreased CD81 cell surface expression occurred through reduced total expression and cytoplasmic retention of CD81 within an endoplasmic reticulum -associated compartment. Moreover, productive viral RNA replication in cells harboring a JFH1 subgenomic replicon containing a similar blasticidin resistance gene cassette in NS5A and in cells robustly replicating full-length infectious genome also reduced permissiveness to HCVpp infection through decreasing the surface expression of CD81. The downregulation of CD81 surface level in HCV RNA highly-replicating cells thus interfered with reinfection and led to attenuated viral amplification. These findings together indicate that the HCV RNA replication status plays a crucial determinant in HCV growth by modulating the expression and intracellular localization of CD81.

  14. Hepatitis C virus induces epidermal growth factor receptor activation via CD81 binding for viral internalization and entry.

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    Diao, Jingyu; Pantua, Homer; Ngu, Hai; Komuves, Laszlo; Diehl, Lauri; Schaefer, Gabriele; Kapadia, Sharookh B

    2012-10-01

    While epidermal growth factor receptor (EGFR) has been shown to be important in the entry process for multiple viruses, including hepatitis C virus (HCV), the molecular mechanisms by which EGFR facilitates HCV entry are not well understood. Using the infectious cell culture HCV model (HCVcc), we demonstrate that the binding of HCVcc particles to human hepatocyte cells induces EGFR activation that is dependent on interactions between HCV and CD81 but not claudin 1. EGFR activation can also be induced by antibody mediated cross-linking of CD81. In addition, EGFR ligands that enhance the kinetics of HCV entry induce EGFR internalization and colocalization with CD81. While EGFR kinase inhibitors inhibit HCV infection primarily by preventing EGFR endocytosis, antibodies that block EGFR ligand binding or inhibitors of EGFR downstream signaling have no effect on HCV entry. These data demonstrate that EGFR internalization is critical for HCV entry and identify a hitherto-unknown association between CD81 and EGFR.

  15. Expression and Purification of Human CD81 Membrane Protein%人膜蛋白CD81的原核表达与纯化

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    朱海珍; 雷少华; 刘春艳; 焦宇; 于晓妍; 高益敏

    2012-01-01

    Based on prokaryotic expression vector pCold TF, a new vector pL118 was constructed by replacing the His-Tag sequence of the original vector with the restriction enzyme site of Spe I in molecular biological methods. His-Tag sequence was introduced to the 3' end of target gene through PCR primer, and this method facilitated the expression of fusion protein and the removal of solubilization tag from the target protein. The fusion protein human CD81-Trigger Factor (TF) was expressed and purified. Human CD81 protein was obtained by removing the TF solubilization tag by proteinase Factor Xa. The purified human CD81 protein laid the foundation for the selection of targeted drugs, making antibody and exploring the function of CD81. The construction of the new expression vector pL118 and the expression and purification of human CD81 protein have provided a new method for obtaining insoluble protein based on the prokaryotic expression system.%以高效原核表达载体pCold TF为载体骨架,应用PCR、限制性酶切、连接等分子生物学方法,将pCold TF中的六聚组氨酸(His-Tag)序列替换为限制性酶切位点Spe Ⅰ序列ACTAGT,构建不含His-Tag序列的新载体pL118.以此载体表达蛋白时,通过PCR引物在目的基因3 '端添加His-Tag以利于融合蛋白的纯化以及融合蛋白中的Trigger Factor(TF)助溶蛋白的去除.应用pL118对人膜蛋白CD81进行原核表达与纯化,并使用Factor Xa蛋白酶去除CD81融合蛋白中的TF助溶蛋白,获得3 '端含有His-Tag的CD81蛋白.人膜蛋白CD81的表达纯化,为CD81靶向药物筛选、抗体制备及深入研究CD81的功能奠定了基础.pL118载体的构建以及CD81蛋白的表达纯化为表达困难的基因实现原核表达提供了一种新的思路和方法.

  16. A novel monoclonal anti-CD81 antibody produced by genetic immunization efficiently inhibits Hepatitis C virus cell-cell transmission.

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    Isabel Fofana

    Full Text Available BACKGROUND AND AIMS: Hepatitis C virus (HCV infection is a challenge to prevent and treat because of the rapid development of drug resistance and escape. Viral entry is required for initiation, spread, and maintenance of infection, making it an attractive target for antiviral strategies. METHODS: Using genetic immunization, we produced four monoclonal antibodies (mAbs against the HCV host entry factor CD81. The effects of antibodies on inhibition of HCV infection and dissemination were analyzed in HCV permissive human liver cell lines. RESULTS: The anti-CD81 mAbs efficiently inhibited infection by HCV of different genotypes as well as a HCV escape variant selected during liver transplantation and re-infecting the liver graft. Kinetic studies indicated that anti-CD81 mAbs target a post-binding step during HCV entry. In addition to inhibiting cell-free HCV infection, one antibody was also able to block neutralizing antibody-resistant HCV cell-cell transmission and viral dissemination without displaying any detectable toxicity. CONCLUSION: A novel anti-CD81 mAb generated by genetic immunization efficiently blocks HCV spread and dissemination. This antibody will be useful to further unravel the role of virus-host interactions during HCV entry and cell-cell transmission. Furthermore, this antibody may be of interest for the development of antivirals for prevention and treatment of HCV infection.

  17. CD81 interacts with the T cell receptor to suppress signaling.

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    Safak Isil Cevik

    Full Text Available CD81 (TAPA-1 is a ubiquitously expressed tetraspanin protein identified as a component of the B lymphocyte receptor (BCR and as a receptor for the Hepatitis C Virus. In an effort to identify trans-membrane proteins that interact with the T-cell antigen receptor (TCR, we performed a membrane yeast two hybrid screen and identified CD81 as an interactor of the CD3delta subunit of the TCR. We found that in the absence of CD81, in thymocytes from knockout mice, TCR engagement resulted in stronger signals. These results were recapitulated in T cell lines that express low levels of CD81 through shRNA mediated silencing. Increased signaling did not result from alterations in the levels of TCR on the surface of T lymphocytes. Although CD81 is not essential for normal T lymphocyte development, it plays an important role in regulating TCR and possibly pre-TCR signal transduction by controlling the strength of signaling. CD81 dependent alterations in thymocyte signaling are evident in increased CD5 expression on CD81 deficient double positive (DP thymocytes. We conclude that CD81 interacts with the T cell receptor to suppress signaling.

  18. Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin

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    Coffey, Greg P.; Rajapaksa, Ranjani; Liu, Raymond; Sharpe, Orr; Kuo, Chiung-Chi; Wald Krauss, Sharon; Sagi, Yael; Davis, R. Eric; Staudt, Louis M.; Sharman, Jeff P.; Robinson, William H.; Levy, Shoshana

    2009-06-09

    CD81 is a tetraspanin family member involved in diverse cellular interactions in the immune and nervous systems and in cell fusion events. However, the mechanism of action of CD81 and of other tetraspanins has not been defined. We reasoned that identifying signaling molecules downstream of CD81 would provide mechanistic clues. We engaged CD81 on the surface of Blymphocytes and identified the induced tyrosine-phosphorylated proteins by mass spectrometry. This analysis showed that the most prominent tyrosine phosphorylated protein was ezrin, an actin binding protein and a member of the ezrin-radixin-moesin family. We also found that CD81 engagement induces spleen tyrosine kinase (Syk) and that Syk was involved in tyrosine phosphorylation of ezrin. Ezrin colocalized with CD81 and F-actin upon stimulation and this association was disrupted when Syk activation was blocked. Taken together, these studies suggest a model in which CD81 interfaces between the plasma membrane and the cytoskeleton by activating Syk, mobilizing ezrin, and recruiting F-actin to facilitate cytoskeletal reorganization and cell signaling. This may be a mechanism explaining the pleiotropic effects induced in response to stimulating cells by anti-CD81 antibodies or by the hepatitis C virus, which uses this molecule as its key receptor.

  19. Recombinant hepatitis C virus-envelope protein 2 interactions with low-density lipoprotein/CD81 receptors

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    Ana Carolina Urbaczek

    2015-06-01

    Full Text Available Hepatitis C virus (HCV envelope protein 2 (E2 is involved in viral binding to host cells. The aim of this work was to produce recombinant E2B and E2Y HCV proteins in Escherichia coli and Pichia pastoris, respectively, and to study their interactions with low-density lipoprotein receptor (LDLr and CD81 in human umbilical vein endothelial cells (HUVEC and the ECV304 bladder carcinoma cell line. To investigate the effects of human LDL and differences in protein structure (glycosylated or not on binding efficiency, the recombinant proteins were either associated or not associated with lipoproteins before being assayed. The immunoreactivity of the recombinant proteins was analysed using pooled serum samples that were either positive or negative for hepatitis C. The cells were immunophenotyped by LDLr and CD81 using flow cytometry. Binding and binding inhibition assays were performed in the presence of LDL, foetal bovine serum (FCS and specific antibodies. The results revealed that binding was reduced in the absence of FCS, but that the addition of human LDL rescued and increased binding capacity. In HUVEC cells, the use of antibodies to block LDLr led to a significant reduction in the binding of E2B and E2Y. CD81 antibodies did not affect E2B and E2Y binding. In ECV304 cells, blocking LDLr and CD81 produced similar effects, but they were not as marked as those that were observed in HUVEC cells. In conclusion, recombinant HCV E2 is dependent on LDL for its ability to bind to LDLr in HUVEC and ECV304 cells. These findings are relevant because E2 acts to anchor HCV to host cells; therefore, high blood levels of LDL could enhance viral infectivity in chronic hepatitis C patients.

  20. Magnetic Resonance Imaging of Atherosclerosis Using CD81-Targeted Microparticles of Iron Oxide in Mice

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    Fei Yan

    2015-01-01

    Full Text Available The goal of this study is to investigate the feasibility of using CD81- (Cluster of Differentiation 81 protein- targeted microparticles of iron oxide (CD81-MPIO for magnetic resonance imaging (MRI of the murine atherosclerosis. CD81-MPIO and IgG- (Immunoglobulin G- MPIO were prepared by covalently conjugating, respectively, with anti-CD81 monoclonal and IgG antibodies to the surface of the tosyl activated MPIO. The relevant binding capability of the MPIO was examined by incubating them with murine bEnd.3 cells stimulated with phenazine methosulfate (PMS and its effect in shortening T2 relaxation time was also examined. MRI in apolipoprotein E-deficient mice was studied in vivo. Our results show that CD81-MPIO, but not IgG-MPIO, can bind to the PMS-stimulated bEnd.3 cells. The T2 relaxation time was significantly shortened for stimulated bEnd.3 cells when compared with IgG-MPIO. In vivo MRI in apolipoprotein E-deficient mice showed highly conspicuous areas of low signal after CD81-MPIO injection. Quantitative analysis of the area of CD81-MPIO contrast effects showed 8.96- and 6.98-fold increase in comparison with IgG-MPIO or plain MPIO, respectively (P<0.01. Histological assay confirmed the expression of CD81 and CD81-MPIO binding onto atherosclerotic lesions. In conclusion, CD81-MPIO allows molecular assessment of murine atherosclerotic lesions by magnetic resonance imaging.

  1. CD81 Inhibits the Proliferation of Astrocytes by Inducing G_0/G_1 Arrest In Vitro

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    马俊芳; 刘仁刚; 彭会明; 周洁萍; 李海朋

    2010-01-01

    Astrocytes play a major role in the reactive processes in response to neuronal injuries in the brain.Excessive gliosis is detrimental and can contribute to neuronal damage.CD81(TAPA),a member of the tetraspanin family of proteins,is upregulated by astrocytes after traumatic injury to the rat central nervous system(CNS).To further understand the role of CD81 in the inhibition of astrocytes,we analyzed the effects of a CD81 antibody,on cultured rat astrocytes.The results indicated that the effect worked in a ...

  2. Interaction of hepatitis C virus envelope glycoprotein E2 with the large extracellular loop of tupaia CD81

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    Zhan-Fei Tian; Hong Shen; Xi-Hua Fu; Yi-Chun Chen; Hubert E Blum; Thomas F Baumert; Xi-Ping Zhao

    2009-01-01

    AIM: To further analyze the interaction of tupaia CD81 with hepatitis C virus (HCV) envelope protein E2. METHODS: A tupaia CD81 large extracellular loop (CD81 LEL), which binds to HCV E2 protein, was cloned and expressed as a GST-fusion protein, and interaction of HCV E2 protein with a tupaia CD81 LEL was evaluated by enzyme-linked immunosorbent assay (EIA). RESULTS: Although tupaia and human CD81 LEL differed in 6 amino acid changes, tupaia CD81 LEL was strongly recognized by anti-CD81 antibodies against human CD81 LEL conformation-dependent epitopes. Investigating LEL CD81-E2 interactions by EIA, we demonstrated that binding of tupaia CD81 LEL GST fusion protein to recombinant HCV E2 protein was markedly reduced compared to binding of human CD81 LEL GST fusion protein to recombinant HCV E2 protein. CONCLUSION: These data suggest that the structural differences in-between the tupaia and human CD81 may alter the interaction of the large extracellular loop with HCV envelope glycoprotein E2. These findings may be important for the understanding of the mechanisms of binding and entry of HCV to PTHs.

  3. CD81 and CD9 work independently as extracellular components upon fusion of sperm and oocyte

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    Naoko Ohnami

    2012-05-01

    When a sperm and oocyte unite into one cell upon fertilization, membranous fusion between the sperm and oocyte occurs. In mice, Izumo1 and a tetraspanin molecule CD9 are required for sperm-oocyte fusion as one of the oocyte factors, and another tetraspanin molecule CD81 is also thought to involve in this process. Since these two tetraspanins often form a complex upon cell-cell interaction, it is probable that such a complex is also formed in sperm-oocyte interaction; however, this possibility is still under debate among researchers. Here we assessed this problem using mouse oocytes. Immunocytochemical analysis demonstrated that both CD9 and CD81 were widely distributed outside the oocyte cell membrane, but these molecules were separate, forming bilayers, confirmed by immunobiochemical analysis. Electron-microscopic analysis revealed the presence of CD9- or CD81-incorporated extracellular structures in those bilayers. Finally, microinjection of in vitro-synthesized RNA showed that CD9 reversed a fusion defect in CD81-deficient oocytes in addition to CD9-deficient oocytes, but CD81 failed in both oocytes. These results suggest that both CD9 and CD81 independently work upon sperm-oocyte fusion as extracellular components.

  4. Radiation increases the cellular uptake of exosomes through CD29/CD81 complex formation

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    Hazawa, Masaharu; Tomiyama, Kenichi; Saotome-Nakamura, Ai; Obara, Chizuka; Yasuda, Takeshi; Gotoh, Takaya; Tanaka, Izumi; Yakumaru, Haruko; Ishihara, Hiroshi; Tajima, Katsushi, E-mail: tajima@nirs.go.jp

    2014-04-18

    Highlights: • Radiation increases cellular uptake of exosomes. • Radiation induces colocalization of CD29 and CD81. • Exosomes selectively bind the CD29/CD81 complex. • Radiation increases the cellular uptake of exosomes through CD29/CD81 complex formation. - Abstract: Exosomes mediate intercellular communication, and mesenchymal stem cells (MSC) or their secreted exosomes affect a number of pathophysiologic states. Clinical applications of MSC and exosomes are increasingly anticipated. Radiation therapy is the main therapeutic tool for a number of various conditions. The cellular uptake mechanisms of exosomes and the effects of radiation on exosome–cell interactions are crucial, but they are not well understood. Here we examined the basic mechanisms and effects of radiation on exosome uptake processes in MSC. Radiation increased the cellular uptake of exosomes. Radiation markedly enhanced the initial cellular attachment to exosomes and induced the colocalization of integrin CD29 and tetraspanin CD81 on the cell surface without affecting their expression levels. Exosomes dominantly bound to the CD29/CD81 complex. Knockdown of CD29 completely inhibited the radiation-induced uptake, and additional or single knockdown of CD81 inhibited basal uptake as well as the increase in radiation-induced uptake. We also examined possible exosome uptake processes affected by radiation. Radiation-induced changes did not involve dynamin2, reactive oxygen species, or their evoked p38 mitogen-activated protein kinase-dependent endocytic or pinocytic pathways. Radiation increased the cellular uptake of exosomes through CD29/CD81 complex formation. These findings provide essential basic insights for potential therapeutic applications of exosomes or MSC in combination with radiation.

  5. Identification of ligands that target the HCV-E2 binding site on CD81

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    Olaby, Reem Al; Azzazy, Hassan M.; Harris, Rodney; Chromy, Brett; Vielmetter, Jost; Balhorn, Rod

    2013-04-01

    Hepatitis C is a global health problem. While many drug companies have active R&D efforts to develop new drugs for treating Hepatitis C virus (HCV), most target the viral enzymes. The HCV glycoprotein E2 has been shown to play an essential role in hepatocyte invasion by binding to CD81 and other cell surface receptors. This paper describes the use of AutoDock to identify ligand binding sites on the large extracellular loop of the open conformation of CD81 and to perform virtual screening runs to identify sets of small molecule ligands predicted to bind to two of these sites. The best sites selected by AutoLigand were located in regions identified by mutational studies to be the site of E2 binding. Thirty-six ligands predicted by AutoDock to bind to these sites were subsequently tested experimentally to determine if they bound to CD81-LEL. Binding assays conducted using surface Plasmon resonance revealed that 26 out of 36 (72 %) of the ligands bound in vitro to the recombinant CD81-LEL protein. Competition experiments performed using dual polarization interferometry showed that one of the ligands predicted to bind to the large cleft between the C and D helices was also effective in blocking E2 binding to CD81-LEL.

  6. Identification of ligands that target the HCV-E2 binding site on CD81.

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    Olaby, Reem Al; Azzazy, Hassan M; Harris, Rodney; Chromy, Brett; Vielmetter, Jost; Balhorn, Rod

    2013-04-01

    Hepatitis C is a global health problem. While many drug companies have active R&D efforts to develop new drugs for treating Hepatitis C virus (HCV), most target the viral enzymes. The HCV glycoprotein E2 has been shown to play an essential role in hepatocyte invasion by binding to CD81 and other cell surface receptors. This paper describes the use of AutoDock to identify ligand binding sites on the large extracellular loop of the open conformation of CD81 and to perform virtual screening runs to identify sets of small molecule ligands predicted to bind to two of these sites. The best sites selected by AutoLigand were located in regions identified by mutational studies to be the site of E2 binding. Thirty-six ligands predicted by AutoDock to bind to these sites were subsequently tested experimentally to determine if they bound to CD81-LEL. Binding assays conducted using surface Plasmon resonance revealed that 26 out of 36 (72 %) of the ligands bound in vitro to the recombinant CD81-LEL protein. Competition experiments performed using dual polarization interferometry showed that one of the ligands predicted to bind to the large cleft between the C and D helices was also effective in blocking E2 binding to CD81-LEL.

  7. Identification of Terfenadine as an Inhibitor of Human CD81-Receptor HCV-E2 Interaction: Synthesis and Structure Optimization

    Directory of Open Access Journals (Sweden)

    Rolf W. Hartmann

    2008-05-01

    Full Text Available Terfenadine (4-[4-(hydroxydiphenylmethyl-1-piperidyl]-1-(4-tert-butylphenyl-butan-1-ol was identified in a biological screening to be a moderate inhibitor (27% inhibition of the CD81-LEL–HCV-E2 interaction. To increase the observed biologicalactivity, 63 terfenadine derivates were synthesized via microwave assisted nucleophilicsubstitution. The prepared compounds were tested for their inhibitory potency by means ofa fluorescence labeled antibody assay using HUH7.5 cells. Distinct structure-activityrelationships could be derived. Optimization was successful, leading to 3g, identfied as themost potent compound (69 % inhibition. Experiments with viral particles revealed thatthere might be additional HCV infection reducing mechanisms.

  8. CD81, a cell cycle regulator, is a novel target for histone deacetylase inhibition in glioma cells.

    Science.gov (United States)

    Gensert, JoAnn M; Baranova, Oxana V; Weinstein, David E; Ratan, Rajiv R

    2007-06-01

    Recent advances in cancer cell biology have focused on histone deacetylase inhibitors (HDACi's) because they target pathways critical to the development and progression of disease. In particular, HDACi's can induce expression of epigenetically silenced genes that promote growth arrest, differentiation and cell death. In glioma cells, one such repressed gene is the tetraspanin CD81, which regulates cytostasis in various cell lines and in astrocytes, the major cellular component of gliomas. Our studies show that HDACi's, trichostatin and sodium butyrate, promote growth arrest and differentiation with negligible cell death in glioma cells and induce expression of CD81 and cyclin-dependent kinase inhibitor 1A (p21(CIP/WAF-1)), another regulator of cytostasis in astrocytes. Interference RNA knock-down of CD81 abrogates cytostasis promoted by HDAC inhibition indicating that HDACi-induced CD81 is responsible for growth arrest. Induction of CD81 expression through HDAC inhibition is a novel strategy to promote growth arrest in glioma cells.

  9. Phage display selection on whole cells yields a small peptide specific for HCV receptor human CD81

    Institute of Scientific and Technical Information of China (English)

    JIE CAO; PING ZHAO; X1AO HUI MIAO; LAN JUAN ZHAO; LI JUN XUE; ZHONG TIAN QI

    2003-01-01

    The human CD81(hCD81),the most recently proposed receptor of hepatitis C virus(HCV),can especifically bind to HCV envelope glycoprotein 2(E2).In this study,hCD81-expressing murine NIH/3T3 cells were used to select hCD81-binding peptides from a phage displayed nonapeptide library(PVIII9aaCys).Eighteen of the 75clones selected from the library showed specific binding to the hCD81-expressing NIH/3T3 cells by enzyme linked immunosorbent assay(ELISA)and competitive inhibition test.Twelve out of the 18 clones shared the amino acid motif SPQYWTGPA.Sequence comparison of the motif showed no amino acid homology with the native HCV E2.The motif-containing phages could competitively inhibit the ability of HCV E2 binding to native hCD81-expressing MOLT-4 cells,and induce HCV E2 specific immune response in vivo.These results suggest that the selected motif SPQYWTGPA should be a mimotope of HCV E2 to bind to hCD81 molecules.Our findings cast new light on developing HCV receptor antagonists.

  10. Clinical significance of CD81 expression by clonal plasma cells in high-risk smoldering and symptomatic multiple myeloma patients.

    Science.gov (United States)

    Paiva, B; Gutiérrez, N-C; Chen, X; Vídriales, M-B; Montalbán, M-Á; Rosiñol, L; Oriol, A; Martínez-López, J; Mateos, M-V; López-Corral, L; Díaz-Rodríguez, E; Pérez, J-J; Fernández-Redondo, E; de Arriba, F; Palomera, L; Bengoechea, E; Terol, M-J; de Paz, R; Martin, A; Hernández, J; Orfao, A; Lahuerta, J-J; Bladé, J; Pandiella, A; Miguel, J-F San

    2012-08-01

    The presence of CD19 in myelomatous plasma cells (MM-PCs) correlates with adverse prognosis in multiple myeloma (MM). Although CD19 expression is upregulated by CD81, this marker has been poorly investigated and its prognostic value in MM remains unknown. We have analyzed CD81 expression by multiparameter flow cytometry in MM-PCs from 230 MM patients at diagnosis included in the Grupo Español de Mieloma (GEM)05>65 years trial as well as 56 high-risk smoldering MM (SMM). CD81 expression was detected in 45% (103/230) MM patients, and the detection of CD81(+) MM-PC was an independent prognostic factor for progression-free (hazard ratio=1.9; P=0.003) and overall survival (hazard ratio=2.0; P=0.02); this adverse impact was validated in an additional series of 325 transplant-candidate MM patients included in the GEM05 <65 years trial. Moreover, CD81(+) SMM (n=34/56, 57%) patients had a shorter time to progression to MM (P=0.02). Overall, our results show that CD81 may have a relevant role in MM pathogenesis and represent a novel adverse prognostic marker in myeloma.

  11. The Association of CD81 Polymorphisms with Alloimmunization in Sickle Cell Disease

    Directory of Open Access Journals (Sweden)

    Zohreh Tatari-Calderone

    2013-01-01

    Full Text Available The goal of the present work was to identify the candidate genetic markers predictive of alloimmunization in sickle cell disease (SCD. Red blood cell (RBC transfusion is indicated for acute treatment, prevention, and abrogation of some complications of SCD. A well-known consequence of multiple RBC transfusions is alloimmunization. Given that a subset of SCD patients develop multiple RBC allo-/autoantibodies, while others do not in a similar multiple transfusional setting, we investigated a possible genetic basis for alloimmunization. Biomarker(s which predicts (predict susceptibility to alloimmunization could identify patients at risk before the onset of a transfusion program and thus may have important implications for clinical management. In addition, such markers could shed light on the mechanism(s underlying alloimmunization. We genotyped 27 single nucleotide polymorphisms (SNPs in the CD81, CHRNA10, and ARHG genes in two groups of SCD patients. One group (35 of patients developed alloantibodies, and another (40 had no alloantibodies despite having received multiple transfusions. Two SNPs in the CD81 gene, that encodes molecule involved in the signal modulation of B lymphocytes, show a strong association with alloimmunization. If confirmed in prospective studies with larger cohorts, the two SNPs identified in this retrospective study could serve as predictive biomarkers for alloimmunization.

  12. MGMT, GATA6, CD81, DR4, and CASP8 gene promoter methylation in glioblastoma

    Directory of Open Access Journals (Sweden)

    Skiriute Daina

    2012-06-01

    Full Text Available Abstract Background Methylation of promoter region is the major mechanism affecting gene expression in tumors. Recent methylome studies of brain tumors revealed a list of new epigenetically modified genes. Our aim was to study promoter methylation of newly identified epigenetically silenced genes together with already known epigenetic markers and evaluate its separate and concomitant role in glioblastoma genesis and patient outcome. Methods The methylation status of MGMT, CD81, GATA6, DR4, and CASP8 in 76 patients with primary glioblastomas was investigated. Methylation-specific PCR reaction was performed using bisulfite treated DNA. Evaluating glioblastoma patient survival time after operation, patient data and gene methylation effect on survival was estimated using survival analysis. Results The overwhelming majority (97.3% of tumors were methylated in at least one of five genes tested. In glioblastoma specimens gene methylation was observed as follows: MGMT in 51.3%, GATA6 in 68.4%, CD81 in 46.1%, DR4 in 41.3% and CASP8 in 56.8% of tumors. Methylation of MGMT was associated with younger patient age (p CASP8 with older (p MGMT methylation was significantly more frequent event in patient group who survived longer than 36 months after operation (p CASP8 was more frequent in patients who survived shorter than 36 months (p MGMT, GATA6 and CASP8 as independent predictors for glioblastoma patient outcome (p MGMT and GATA6 were independent predictors for patient survival in younger patients’ group, while there were no significant associations observed in older patients’ group when adjusted for therapy. Conclusions High methylation frequency of tested genes shows heterogeneity of glioblastoma epigenome and the importance of MGMT, GATA6 and CASP8 genes methylation in glioblastoma patient outcome.

  13. 9 CFR 71.12 - Sodium orthophenylphenate as permitted disinfectant for premises infected with tuberculosis.

    Science.gov (United States)

    2010-01-01

    ... disinfectant for premises infected with tuberculosis. 71.12 Section 71.12 Animals and Animal Products ANIMAL... disinfectant for premises infected with tuberculosis. (a) A permitted brand of sodium orthophenylphenate in a proportion of at least one pound to 12 gallons of water is permitted in tuberculosis eradication work...

  14. Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association.

    Science.gov (United States)

    Little, Kevin D; Hemler, Martin E; Stipp, Christopher S

    2004-05-01

    By means of a variety of intracellular scaffolding proteins, a vast number of heterotrimeric G protein-coupled receptors (GPCRs) may achieve specificity in signaling through a much smaller number of heterotrimeric G proteins. Members of the tetraspanin family organize extensive complexes of cell surface proteins and thus have the potential to act as GPCR scaffolds; however, tetraspanin-GPCR complexes had not previously been described. We now show that a GPCR, GPR56/TM7XN1, and heterotrimeric G protein subunits, Galpha(q), Galpha(11), and Gbeta, associate specifically with tetraspanins and CD81, but not with other tetraspanins. CD9 Complexes of GPR56 with CD9 and CD81 remained intact when fully solubilized and were resistant to cholesterol depletion. Hence they do not depend on detergent-insoluble, raft-like membrane microdomains for stability. A central role for CD81 in promoting or stabilizing a GPR56-CD81-Galpha(q/11) complex was revealed by CD81 immunodepletion and reexpression experiments. Finally, antibody engagement of cell surface CD81 or cell activation with phorbol ester revealed two distinct mechanisms by which GPR56-CD81-Galpha(q/11) complexes can be dynamically regulated. These data reveal a potential role for tetraspanins CD9 and CD81 as GPCR scaffolding proteins.

  15. Hepatitis C Virus Induces Epidermal Growth Factor Receptor Activation via CD81 Binding for Viral Internalization and Entry

    OpenAIRE

    Diao, Jingyu; Pantua, Homer; Ngu, Hai; Komuves, Laszlo; Diehl, Lauri; Schaefer, Gabriele; Kapadia, Sharookh B.

    2012-01-01

    While epidermal growth factor receptor (EGFR) has been shown to be important in the entry process for multiple viruses, including hepatitis C virus (HCV), the molecular mechanisms by which EGFR facilitates HCV entry are not well understood. Using the infectious cell culture HCV model (HCVcc), we demonstrate that the binding of HCVcc particles to human hepatocyte cells induces EGFR activation that is dependent on interactions between HCV and CD81 but not claudin 1. EGFR activation can also be ...

  16. Membrane-Associated RING-CH proteins associate with Bap31 and target CD81 and CD44 to lysosomes.

    Directory of Open Access Journals (Sweden)

    Eric Bartee

    Full Text Available Membrane-associated RING-CH (MARCH proteins represent a family of transmembrane ubiquitin ligases modulating intracellular trafficking and turnover of transmembrane protein targets. While homologous proteins encoded by gamma-2 herpesviruses and leporipoxviruses have been studied extensively, limited information is available regarding the physiological targets of cellular MARCH proteins. To identify host cell proteins targeted by the human MARCH-VIII ubiquitin ligase we used stable isotope labeling of amino-acids in cell culture (SILAC to monitor MARCH-dependent changes in the membrane proteomes of human fibroblasts. Unexpectedly, we observed that MARCH-VIII reduced the surface expression of Bap31, a chaperone that predominantly resides in the endoplasmic reticulum (ER. We demonstrate that Bap31 associates with the transmembrane domains of several MARCH proteins and controls intracellular transport of MARCH proteins. In addition, we observed that MARCH-VIII reduced the surface expression of the hyaluronic acid-receptor CD44 and both MARCH-VIII and MARCH-IV sequestered the tetraspanin CD81 in endo-lysosomal vesicles. Moreover, gene knockdown of MARCH-IV increased surface levels of endogenous CD81 suggesting a constitutive involvement of this family of ubiquitin ligases in the turnover of tetraspanins. Our data thus suggest a role of MARCH-VIII and MARCH-IV in the regulated turnover of CD81 and CD44, two ubiquitously expressed, multifunctional proteins.

  17. Membrane-Associated RING-CH proteins associate with Bap31 and target CD81 and CD44 to lysosomes.

    Science.gov (United States)

    Bartee, Eric; Eyster, Craig A; Viswanathan, Kasinath; Mansouri, Mandana; Donaldson, Julie G; Früh, Klaus

    2010-12-02

    Membrane-associated RING-CH (MARCH) proteins represent a family of transmembrane ubiquitin ligases modulating intracellular trafficking and turnover of transmembrane protein targets. While homologous proteins encoded by gamma-2 herpesviruses and leporipoxviruses have been studied extensively, limited information is available regarding the physiological targets of cellular MARCH proteins. To identify host cell proteins targeted by the human MARCH-VIII ubiquitin ligase we used stable isotope labeling of amino-acids in cell culture (SILAC) to monitor MARCH-dependent changes in the membrane proteomes of human fibroblasts. Unexpectedly, we observed that MARCH-VIII reduced the surface expression of Bap31, a chaperone that predominantly resides in the endoplasmic reticulum (ER). We demonstrate that Bap31 associates with the transmembrane domains of several MARCH proteins and controls intracellular transport of MARCH proteins. In addition, we observed that MARCH-VIII reduced the surface expression of the hyaluronic acid-receptor CD44 and both MARCH-VIII and MARCH-IV sequestered the tetraspanin CD81 in endo-lysosomal vesicles. Moreover, gene knockdown of MARCH-IV increased surface levels of endogenous CD81 suggesting a constitutive involvement of this family of ubiquitin ligases in the turnover of tetraspanins. Our data thus suggest a role of MARCH-VIII and MARCH-IV in the regulated turnover of CD81 and CD44, two ubiquitously expressed, multifunctional proteins.

  18. Biopanning and Identification of Peptides Capable to Inhibit the Interaction between hCD81 and HCV E2 Protein%能结合HCV E2蛋白的人CD81模拟肽的筛选与活性鉴定

    Institute of Scientific and Technical Information of China (English)

    廖小玲; 曹洁; 吴淑梅; 赵平; 高军; 戚中田

    2006-01-01

    目的 用CD81单克隆抗体筛选噬菌体随机展示十二肽库,以期得到可模拟人CD81功能位点、能抑制HCV E2与其受体一人CD81分子结合的小肽.方法 用CD81单抗从噬菌体随机展示十二肽库中筛选人CD81模拟肽,用ELISA鉴定阳性噬菌体克隆;以阳性噬菌体免疫BALB/c小鼠,分析小鼠免疫血清对阳性噬菌体与HCV E2结合的阻断作用;以HCV E2蛋白包被酶标板,检测阳性噬菌体对HCV E2与人CD81分子结合的抑制作用.结果 对十二肽库进行3轮筛选后,经ELISA和DNA测序,鉴定出3个(C4,C13和C16)阳性克隆,与人CD81无同源序列.阳性噬菌体克隆C16免疫小鼠血清能阻断该克隆与HCV E2的结合.C16克隆能以剂量依赖的方式竞争性抑制HCV E2蛋白与人CD81的结合.结论 用人CD81单抗从噬菌体随机展示肽库中筛选出的阳性噬菌体克隆所编码的小肽在功能上能模拟人CD81与HCV E2的结合活性,能竞争性抑制HCV E2与人CD81分子的结合,在抗HCV药物及疫苗研究中具有潜在应用价值.

  19. Scavenger receptor BI boosts hepatocyte permissiveness to Plasmodium infection.

    NARCIS (Netherlands)

    Yalaoui, S.; Huby, T.; Franetich, J.F.; Gego, A.; Rametti, A.; Moreau, M.; Collet, X.; Siau, A.; Gemert, G.J.A. van; Sauerwein, R.W.; Luty, A.J.F.; Vaillant, J.C.; Hannoun, L.; Chapman, J.; Mazier, D.; Froissard, P.

    2008-01-01

    Infection of hepatocytes by Plasmodium falciparum sporozoites requires the host tetraspanin CD81. CD81 is also predicted to be a coreceptor, along with scavenger receptor BI (SR-BI), for hepatitis C virus. Using SR-BI-knockout, SR-BI-hypomorphic and SR-BI-transgenic primary hepatocytes, as well as s

  20. Tetraspanins CD81 and CD82 facilitate α4β1-mediated adhesion of human erythroblasts to vascular cell adhesion molecule-1.

    Directory of Open Access Journals (Sweden)

    Frances A Spring

    Full Text Available The proliferation and terminal differentiation of erythroid progenitors occurs in human bone marrow within erythroblastic islands, specialised structures consisting of a central macrophage surrounded by developing erythroid cells. Many cell-cell and cell-matrix adhesive interactions maintain and regulate the co-ordinated daily production of reticulocytes. Erythroid cells express only one integrin, α4β1, throughout differentiation, and its interactions with both macrophage Vascular Cell Adhesion Molecule-1 and with extracellular matrix fibronectin are critical for erythropoiesis. We observed that proerythroblasts expressed a broad tetraspanin phenotype, and investigated whether any tetraspanin could modulate integrin function. A specific association between α4β1 and CD81, CD82 and CD151 was demonstrated by confocal microscopy and co-immune precipitation. We observed that antibodies to CD81 and CD82 augmented adhesion of proerythroblasts to Vascular Cell Adhesion Molecule-1 but not to the fibronectin spliceoforms FnIII12-IIICS-15 and FnIII12-15. In contrast, different anti-CD151 antibodies augmented or inhibited adhesion of proerythroblasts to Vascular Cell Adhesion Molecule-1 and the fibronectin spliceoform FnIII12-IIICS-15 but not to FnIII12-15. These results strongly suggest that tetraspanins have a functional role in terminal erythropoiesis by modulating interactions of erythroblast α4β1 with both macrophages and extracellular matrix.

  1. Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs

    DEFF Research Database (Denmark)

    Gottwein, Judith M; Scheel, Troels K H; Jensen, Tanja B

    2009-01-01

    Six major hepatitis C virus (HCV) genotypes and numerous subtypes have been described, and recently a seventh major genotype was discovered. Genotypes show significant molecular and clinical differences, such as differential response to combination therapy with interferon-alpha and ribavirin...... against the putative coreceptors CD81 and scavenger receptor class B type I in a dose-dependent manner. Finally, neutralizing antibodies in selected chronic phase HCV sera had differential effects against genotype 1-7 viruses. Conclusion: We completed and characterized a panel of JFH1-based cell culture...... systems of all seven major HCV genotypes and important subtypes and used these viruses in comparative studies of antivirals, HCV receptor interaction, and neutralizing antibodies....

  2. Different Responses of Two Highly Permissive Cell Lines Upon HCV Infection

    Institute of Scientific and Technical Information of China (English)

    Honghe Chen; Rongjuan Pei; Xinwen Chen

    2013-01-01

    The construction of the first infectious clone JFH-1 speeds up the research on hepatitis C virus (HCV).However,Huh7 cell line was the only highly permissive cell line for HCV infection and only a few clones were fully permissive.In this study,two different fully permissive clones of Huh7 cells,Huh7.5.1 and Huh7-Lunet-CD81 (Lunet-CD81) cells were compared for their responses upon HCV infection.The virus replication level was found slightly higher in Huh7.5.1 cells than that in Lunet-CD81 cells.Viability of Huh7.5.1 cells but not of Lunet-CD81 cells was reduced significantly after HCV infection.Further analysis showed that the cell cycle of infected Huh7.5.1 cells was arrested at G1 phase.The G1/S transition was blocked by HCV infection in Huh7.5.1 cells as shown by the cell cycle synchronization analysis.Genes related to cell cycle regulation was modified by HCV infection and gene interaction analysis in GeneSpring GX in Direct Interactions mode highlighted 31 genes.In conclusion,the responses of those two cell lines were different upon HCV infection.HCV infection blocked G1/S transition and cell cycle progress,thus reduced the cell viability in Huh7.5.1 cells but not in Lunet-CD81 cells.Lunet-CD81 cells might be suitable for long term infection studies of HCV.

  3. Negative regulation of type I IFN expression by OASL1 permits chronic viral infection and CD8⁺ T-cell exhaustion.

    Directory of Open Access Journals (Sweden)

    Myeong Sup Lee

    Full Text Available The type I interferons (IFN-Is are critical not only in early viral control but also in prolonged T-cell immune responses. However, chronic viral infections such as those of human immunodeficiency virus (HIV and hepatitis C virus (HCV in humans and lymphocytic choriomeningitis virus (LCMV in mice overcome this early IFN-I barrier and induce viral persistence and exhaustion of T-cell function. Although various T-cell-intrinsic and -extrinsic factors are known to contribute to induction of chronic conditions, the roles of IFN-I negative regulators in chronic viral infections have been largely unexplored. Herein, we explored whether 2'-5' oligoadenylate synthetase-like 1 (OASL1, a recently defined IFN-I negative regulator, plays a key role in the virus-specific T-cell response and viral defense against chronic LCMV. To this end, we infected Oasl1 knockout and wild-type mice with LCMV CL-13 (a chronic virus and monitored T-cell responses, serum cytokine levels, and viral titers. LCMV CL-13-infected Oasl1 KO mice displayed a sustained level of serum IFN-I, which was primarily produced by splenic plasmacytoid dendritic cells, during the very early phase of infection (2-3 days post-infection. Oasl1 deficiency also led to the accelerated elimination of viremia and induction of a functional antiviral CD8 T-cell response, which critically depended on IFN-I receptor signaling. Together, these results demonstrate that OASL1-mediated negative regulation of IFN-I production at an early phase of infection permits viral persistence and suppresses T-cell function, suggesting that IFN-I negative regulators, including OASL1, could be exciting new targets for preventing chronic viral infection.

  4. Ci PERMIT

    CERN Multimedia

    Relations with the Host States Service

    1999-01-01

    The Swiss Permanent Mission to the International Organisations at Geneva recalls that only the spouses and children of members of personnel resident in Switzerland and in possession of a legitimation card of types 'B', 'C', 'D' or 'E' issued by the Swiss Federal Department of Foreign Affairs are entitled to benefit from a Ci Permit.The 'demande d'attestation de permis Ci' (request for a Ci permit attestation) can be sent to the Mission only through Personnel Division (Administrative Services, Office 33/1-025).Additional information on access by family members of CERN officials to the Swiss labour market are available to you on the Web site of the Relations with the Host States Service (cf. document entitled 'Employment in Switzerland for spouses and children of CERN officials' dated March 1996).Relations with the Host States Servicehttp://www.cern.ch/relations/Tel. 72848

  5. Permitted Exceptions

    DEFF Research Database (Denmark)

    Wagner, Anne Margrethe

    This PhD thesis examines the phenomenon of temporary use in a contemporary Northern European planning context. The background for the study is the increasing interest in initiating temporary use projects within urban redevelopment by public authorities, such as municipalities, related sub......-term perspectives. This factor seems to hold some, if not conflicting, then at least challenging aspects. Current research is inadequate to disclose what actually happens when integrating temporary exceptions into urban transformation projects. I define, document and explore these attempts as permitted exceptions...

  6. Human Ezrin-Moesin-Radixin Proteins Modulate Hepatitis C Virus Infection

    OpenAIRE

    Bukong, Terence N; Kodys, Karen; Szabo, Gyongyi

    2013-01-01

    Host cytoskeletal proteins of the ezrin-moesin-radixin (EMR) family have been shown to modulate single-stranded RNA virus infection through regulating stable microtubule formation. Antibody engagement of CD81, a key receptor for HCV entry, induces ezrin phosphorylation. Here we tested the role of EMR proteins in regulating HCV infection and explored potential therapeutic targets. We show that HCV E2 protein induces rapid ezrin phosphorylation and its cellular redistribution with F-actin via s...

  7. Federal Fisheries Permit (FFP)/ Federal Processor Permit (FPP) Permit Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Federal Fisheries Permit (FFP) is required for vessels of the United States which are used to fish for groundfish in the Gulf of Alaska or Bering Sea and...

  8. Permit.LOA table

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This table includes the effective dates by vessel and permit number for each issued letter of authorization (LOA) by the Permit Office (APSD)

  9. State Licenses & Permits

    Data.gov (United States)

    Small Business Administration — Starting a business? Confused about whether you need a business license or permit? Virtually every business needs some form of license or permit to operate legally....

  10. CCS Project Permit Acquisition Protocols

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Si-Yong; Zaluski, Wade; Matthews, Vince; McPherson, Brian

    2013-06-30

    Geologic carbon storage projects require a vast range of permits prior to deployment. These include land-access permits, drilling permits, seismic survey permits, underground injection control permits, and any number of local and state permits, depending on the location of the project. For the “Characterization of Most Promising Sequestration Formations in the Rocky Mountain Region” (RMCCS) project in particular, critical permits included site access permits, seismic survey permits, and drilling permits for the characterization well. Permits for these and other activities were acquired either prior to or during the project.

  11. HCV Infection and B-Cell Lymphomagenesis

    Directory of Open Access Journals (Sweden)

    Masahiko Ito

    2011-01-01

    Full Text Available Hepatitis C virus (HCV has been recognized as a major cause of chronic liver diseases worldwide. It has been suggested that HCV infects not only hepatocytes but also mononuclear lymphocytes including B cells that express the CD81 molecule, a putative HCV receptor. HCV infection of B cells is the likely cause of B-cell dysregulation disorders such as mixed cryoglobulinemia, rheumatoid factor production, and B-cell lymphoproliferative disorders that may evolve into non-Hodgkin's lymphoma (NHL. Epidemiological data indicate an association between HCV chronic infection and the occurrence of B-cell NHL, suggesting that chronic HCV infection is associated at least in part with B-cell lymphomagenesis. In this paper, we aim to provide an overview of recent literature, including our own, to elucidate a possible role of HCV chronic infection in B-cell lymphomagenesis.

  12. Hepatoma polarization limits CD81 and hepatitis C virus dynamics

    NARCIS (Netherlands)

    Harris, H. J.; Clerte, C.; Farquhar, M. J.; Goodall, M.; Hu, K.; Rassam, P.; Dosset, P.; Wilson, G. K.; Balfe, P.; IJzendoorn, S. C.; Milhiet, P. E.; McKeating, J. A.

    2013-01-01

    Many viruses target the polarized epithelial apex during host invasion. In contrast, hepatitis C virus (HCV) engages receptors at the basal surface of hepatocytes in the polarized liver parenchyma. Hepatocyte polarization limits HCV entry by undefined mechanism(s). Given the recent reports highlight

  13. BCDC Minor Permits

    Data.gov (United States)

    California Department of Resources — An administrative permit can be issued for an activity that qualifies as a minor repair or improvement in a relatively short period of time and without a public...

  14. Coal Mine Permit Boundaries

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — ESRI ArcView shapefile depicting New Mexico coal mines permitted under the Surface Mining Control and Reclamation Act of 1977 (SMCRA), by either the NM Mining these...

  15. BCDC Major Permits

    Data.gov (United States)

    California Department of Resources — Data depicts the majority of the major permits that BCDC has issued. Data has been created by a team of interns and staff and has been digitized using maps provided...

  16. California Tribal Gasoline Permits

    Science.gov (United States)

    EPA is proposing a draft general permit under the Clean Air Act Federal Indian Country Minor NSR program for gasoline dispensing facilities, such as gas stations, located in Indian country within the geographical boundaries of California.

  17. Allegheny County Asbestos Permits

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Asbestos permit data issued by the County for commercial building demolitions and renovations as required by the EPA. This file is updated daily and can be...

  18. Hanford Facility RCRA permit handbook

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    Purpose of this Hanford Facility (HF) RCRA Permit Handbook is to provide, in one document, information to be used for clarification of permit conditions and guidance for implementing the HF RCRA Permit.

  19. Acute hepatitis C virus infection induces anti-host cell receptor antibodies with virus-neutralizing properties.

    Science.gov (United States)

    Tawar, Rajiv G; Colpitts, Che C; Timm, Jörg; Fehm, Tanja; Roggendorf, Michael; Meisel, Helga; Meyer, Nicolas; Habersetzer, François; Cosset, François-Loïc; Berg, Thomas; Zeisel, Mirjam B; Baumert, Thomas F

    2015-09-01

    Hepatitis C virus (HCV) causes persistent infection in the majority of infected individuals. The mechanisms of persistence and clearance are only partially understood. Antibodies (Abs) against host cell entry receptors have been shown to inhibit HCV infection in cell culture and animal models. In this study, we aimed to investigate whether anti-receptor Abs are induced during infection in humans in vivo and whether their presence is associated with outcome of infection. We established an enzyme-linked immunosorbant assay using a recombinant CD81-claudin-1 (CLDN1) fusion protein to detect and quantify Abs directed against extracellular epitopes of the HCV CD81-CLDN1 coreceptor complex. The presence of anti-receptor Abs was studied in serum of patients from a well-defined cohort of a single-source HCV outbreak of pregnant women and several control groups, including uninfected pregnant women, patients with chronic hepatitis B and D virus (HBV/HDV) infection, and healthy individuals. Virus-neutralizing activity of Abs was determined using recombinant cell culture-derived HCV (HCVcc). Our results demonstrate that HCV-infected patients have statistically significantly higher anti-CD81/CLDN1 Ab titers during the early phase of infection than controls. The titers were significantly higher in resolvers compared to persisters. Functional studies using immunoadsorption and HCV cell culture models demonstrate that HCV-neutralizing anti-receptor Abs are induced in the early phase of HCV infection, but not in control groups. The virus-neutralizing properties of these Abs suggest a role for control of viral infection in conjunction with antiviral responses. Characterization of these anti-receptor Abs opens new avenues to prevent and treat HCV infection. © 2015 by the American Association for the Study of Liver Diseases.

  20. Approaches to Streamline Air Permitting for Combined Heat and Power: Permits by Rule and General Permits

    Science.gov (United States)

    This factsheet provides information about permit by rule (PBR) and general permit (GP) processes, including the factors that contributed to their development and lessons learned from their implementation.

  1. Permit application modifications

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-11-01

    This document contains the Permit Application Modifications for the Y-12 Industrial Landfill V site on the Oak Ridge Reservation. These modifications include the assessment of stability of the proposed Landfill V under static and loading conditions. Analyses performed include the general slope stability, veneer stability of the bottom liner and cover system, and a liquefaction potential assessment of the foundation soils.

  2. Infections

    Science.gov (United States)

    ... Does My Child Need? How to Safely Give Acetaminophen Is It a Cold or the Flu? Is the Flu Vaccine a Good Idea for Your Family? Too Late for the Flu Vaccine? Common Childhood Infections Can Chronic Ear Infections Cause Long-Term Hearing Loss? Chickenpox Cold Sores Common Cold Diarrhea Fever and ...

  3. Wind Energy: Offshore Permitting

    Science.gov (United States)

    2008-05-01

    Technological advancements and tax incentives have driven a global expansion in the development of renewable energy resources. Wind energy , in...particular, is now often cited as the fastest growing commercial energy source in the world. Currently, all U.S. wind energy facilities are based on land...authority to permit and regulate offshore wind energy development within the zones of the oceans under its jurisdiction. The federal government and coastal

  4. A new clue for the pathogenesis of hepatitis C virus infection: Activation of the MAPK/ ERK signaling initiated by envelope protein 2

    Institute of Scientific and Technical Information of China (English)

    ZHAO; Lanjuan; (赵兰娟); LIU; Houqi; (刘厚奇); ZHU; Shiying; (朱诗应); FENG; Gensheng; (冯根生); QI; Zhongtian; (戚中田)

    2003-01-01

    Since cell signal transduction plays an important role in disclosing the nature of human diseases, the pathogenesis of viruses may result from the disturbance of intracellular signal cascades caused by viral proteins. Hepatitis C virus (HCV) is a main causative agent of severe human liver disorders worldwide. So far, the mechanisms of HCV pathogenicity remain unclear. Envelope protein 2 (E2) of HCV is thought to be responsible for initiating virus attachment to host cells, which is a prerequisite of HCV infection. We assume that some early events of HCV pathogenic effects may result from the interaction of HCV E2 protein with its cellular receptor (human CD81), which could regulate cell proliferation and differentiation. To test this hypothesis, the effects of HCV E2 protein on MAPK/ERK pathway in Molt-4 and U937 cells with or without human CD81 expression were investigated. The results showed that HCV E2 protein could specifically activate the MAPK/ERK pathway, and such activation was inhibited by monoclonal antibodies against CD81 or HCV E2, serum antibodies from HCV infected patients, and upstream MEK1 inhibitor PD98059. Moreover, HCV E2-driven MAPK/ERK or downstream transcription factor Elk-1 activation was completely blocked in the presence of PD98059. These findings strongly suggest that the regulation of transmembrane signaling by HCV E2 protein via its receptor(s) on host cells might contribute to the development of HCV-related diseases.

  5. Infections

    Directory of Open Access Journals (Sweden)

    Virginia Vanzzini Zago

    2012-01-01

    Full Text Available This is a retrospective, and descriptive study about the support that the laboratory of microbiology aids can provide in the diagnosis of ocular infections in patients whom were attended a tertiary-care hospital in México City in a 10-year-time period. We describe the microbiological diagnosis in palpebral mycose; in keratitis caused by Fusarium, Aspergillus, Candida, and melanized fungi; endophthalmitis; one Histoplasma scleritis and one mucormycosis. Nowadays, ocular fungal infections are more often diagnosed, because there is more clinical suspicion and there are easy laboratory confirmations. Correct diagnosis is important because an early medical treatment gives a better prognosis for visual acuity. In some cases, fungal infections are misdiagnosed and the antifungal treatment is delayed.

  6. Pacific Islands Region Fishing Permits

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Sustainable Fisheries Division Permits Program issues around 300 permits annually for pelagic longline and troll & handline, bottomfish, crustacean (lobster...

  7. Vessel Permit System Data Set

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — GARFO issues federal fishing permits annually to owners of fishing vessels who fish in the Greater Atlantic region, as required by federal regulation. These permits...

  8. Regulatory and Permitting Issues

    Energy Technology Data Exchange (ETDEWEB)

    Larry Myer

    2005-12-01

    As part of the West Coast Regional Carbon Sequestration Partnership (WESTCARB), Terralog Technologies USA, Inc., reviewed current state and federal regulations related to carbon dioxide capture and storage within geologic formations and enhanced carbon uptake in terrestrial ecosystems. We have evaluated and summarized the current and possible future permitting requirements for the six states that comprise the West Coast Regional Partnership. Four options exist for CO{sub 2} injection into appropriate geologic formations, including storage in: (1) oil and gas reservoirs, (2) saline formations, (3) unmineable coal beds, and (4) salt caverns. Terrestrial CO{sub 2} sequestration involves improved carbon conservation management (e.g. reduction of deforestation), carbon substitution (e.g., substitution for fossil fuel-based products, energy conservation through urban forestry, biomass for energy generation), and improved carbon storage management (e.g., expanding the storage of carbon in forest ecosystems). The primary terrestrial options for the West Coast Region include: (1) reforestation of under-producing lands (including streamside forest restoration), (2) improved forest management, (3) forest protection and conservation, and (4) fuel treatments for the reduction of risk of uncharacteristically severe fires (potentially with associated biomass energy generation). The permits and/or contracts required for any land-use changes/disturbances and biomass energy generation that may occur as part of WESTCARB's activities have been summarized for each state.

  9. Infection

    Science.gov (United States)

    2010-09-01

    Interactions between biofilms and the environment. FEMS Microbiol Rev. 1997;20:291–303. 4. Webb LX, Wagner W, Carroll D, et al. Osteomyelitis and...treatment of osteomyelitis . Biomed Mater. 2008;3: 034114. 6. Gristina AG. Biomaterial-centered infection: microbial adhesion versus tissue integration...vertebral osteomyelitis . Spine. 2007;32: 2996–3006. 15. Beckham JD, Tuttle K, Tyler KL. Reovirus activates transforming growth factor ß and bone

  10. Cell-Cell Contact-Mediated Hepatitis C Virus (HCV) Transfer, Productive Infection, and Replication and Their Requirement for HCV Receptors

    OpenAIRE

    Liu, Ziqing; He, Johnny J.

    2013-01-01

    Hepatitis C virus (HCV) infection is believed to begin with interactions between cell-free HCV and cell receptors that include CD81, scavenger receptor B1 (SR-B1), claudin-1 (CLDN1), and occludin (OCLN). In this study, we have demonstrated that HCV spreading from infected hepatocytes to uninfected hepatocytes leads to the transfer of HCV and the formation of infection foci and is cell density dependent. This cell-cell contact-mediated (CCCM) HCV transfer occurs readily and requires all these ...

  11. Avoiding Title V permitting pitfalls

    Energy Technology Data Exchange (ETDEWEB)

    Laswell, D.L.

    1993-04-01

    Title V of the 1990 Clean Air Act Amendments requires states to implement new air operating permit programs. States have a great deal of flexibility in developing their permit programs. Industry should work now to ensure that state programs contain the favorable aspects of the federal regulations and do not contain more stringent requirements that are not required under the Clean Air Act. This article outlines areas of the permit program that have the potential to handicap industry`s ability to expand.

  12. Tradeable Emission Permits in Oligopoly

    NARCIS (Netherlands)

    Fershtman, C.; de Zeeuw, A.J.

    1996-01-01

    The paper considers an oligopolistic industry in which pollution is a by-product of production. Firms are assumed to have emission permits that restrict the amount that they pollute. These permits are assumed to be tradeable and the paper discusses a structure in which the same set of firms operates

  13. 2008 Contruction General Permits & Multi-Sector General Permits

    Data.gov (United States)

    U.S. Environmental Protection Agency — View stormwater notices of intent (NOIs) for construction projects under EPA's 2008 Construction General Permit (CGP), for Low Erosivity Waivers (LEWs) submitted...

  14. Noncooperative models of permit markets

    Energy Technology Data Exchange (ETDEWEB)

    Godal, Odd

    2011-07-15

    The applicability of some popular and basic permit market theories has been questioned. Drawing on noncooperative equilibrium theory for pure exchange economies, this article adapts several well-established alternative models to permit exchange. Some qualitative properties of the associated equilibria are provided, including two games with equilibria that in a sense coincide. Nevertheless, as there exist quite a few models potentially applicable to emissions trading, with equilibria that range from autarky to Pareto optimality, it seems that economics lacks a broadly accepted basic theory for permit markets. (Author)

  15. Permitting - the latest mining risk

    Energy Technology Data Exchange (ETDEWEB)

    Hume, W.M.; Munn, F.J. [Cardinal River Coals Ltd., Hinton, AB (Canada)

    1995-05-01

    The Cheviot approach to mine permitting and the status of the Cheviot permitting process are described. The mine is the first Canadian metallurgical mine built since the early 1970s and will replace the Luscar Mine. There have been significant changes in the technology of mining equipment and with the requirements for government regulatory approvals since 1980, when the last mines were built. A permit application must be technically complete and must be legally correct. A valid public involvement process must support an application. A permit application is now an entire process that leads to submission and review of a document. Cardinal River Coals is applying two principles in order to meet these objectives: to be technically advanced and show the ability to manage the environment; and to conduct a proactive and effective public involvement program.

  16. Dakota Magic Casino NPDES Permit

    Science.gov (United States)

    Under NPDES permit ND-0030813, the Dakota Nation Gaming Enterprise is authorized to discharge from the wastewater treatment facility in Richland County, North Dakota, to a roadside ditch flowing to an unnamed tributary to the Bois de Sioux.

  17. Permit trading and credit trading

    DEFF Research Database (Denmark)

    Boom, Jan-Tjeerd; R. Dijstra, Bouwe

    This paper compares emissions trading based on a cap on total emissions (permit trading) and on relative standards per unit of output (credit trading). Two types of market structure are considered: perfect competition and Cournot oligopoly. We find that output, abatement costs and the number...... of firms are higher under credit trading. Allowing trade between permit-trading and credit-trading sectors may increase in welfare. With perfect competition, permit trading always leads to higher welfare than credit trading. With imperfect competition, credit trading may outperform permit trading....... Environmental policy can lead to exit, but also to entry of firms. Entry and exit have a profound impact on the performance of the schemes, especially under imperfect competition. We find that it may be impossible to implement certain levels of total industry emissions. Under credit trading several levels...

  18. Factors Influencing Learner Permit Duration

    Directory of Open Access Journals (Sweden)

    Johnathon P. Ehsani

    2016-12-01

    Full Text Available An increasing number of countries are requiring an extended learner permit prior to independent driving. The question of when drivers begin the learner permit period, and how long they hold the permit before advancing to independent licensure has received little research attention. Licensure timing is likely to be related to “push” and “pull” factors which may encourage or inhibit the process. To examine this question, we recruited a sample of 90 novice drivers (49 females and 41 males, average age of 15.6 years soon after they obtained a learner permit and instrumented their vehicles to collect a range of driving data. Participants completed a series of surveys at recruitment related to factors that may influence licensure timing. Two distinct findings emerged from the time-to-event analysis that tested these push and pull factors in relation to licensure timing. The first can be conceptualized as teens’ motivation to drive (push, reflected in a younger age when obtaining a learner permit and extensive pre-permit driving experience. The second finding was teens’ perceptions of their parents’ knowledge of their activities (pull; a proxy for a parents’ attentiveness to their teens’ lives. Teens who reported higher levels of their parents’ knowledge of their activities took longer to advance to independent driving. These findings suggest time-to-licensure may be related to teens’ internal motivation to drive, and the ability of parents to facilitate or impede early licensure.

  19. 50 CFR 13.28 - Permit revocation.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false Permit revocation. 13.28 Section 13.28... GENERAL PERMIT PROCEDURES Permit Administration § 13.28 Permit revocation. (a) Criteria for revocation. A... revocation. (1) When the issuing officer believes there are valid grounds for revoking a permit,...

  20. 9 CFR 104.2 - Permit authorized.

    Science.gov (United States)

    2010-01-01

    ... permits for importing biological products. They shall be: (1) U.S. Veterinary Biological Product Permit for Research and Evaluation; (2) U.S. Veterinary Biological Product Permit for Distribution and Sale; or (3) U.S. Veterinary Biological Product Permit for Transit Shipment Only. (b) A permit shall not be...

  1. Water Quality Trading Toolkit for Permit Writers

    Science.gov (United States)

    The Water Quality Trading Toolkit for Permit Writers is EPA’s first “how-to” manual on designing and implementing water quality trading programs. It helps NPDES permitting authorities incorporate trading provisions into permits.

  2. FIRE PERMIT NOW ON EDH!

    CERN Multimedia

    TIS General Safety Group or

    2001-01-01

    The electronic version of the Fire Permit form is now active. The aim of the Fire Permit procedure is to reduce the risk of fire or explosion. It is mandatory when performing 'hot work' (mainly activities which involve the use of naked flames or other heat sources - e.g. welding, brazing, cutting, grinding, etc.). Its use is explained in the CERN Fire Protection Code E. (Fire Protection) The new electronic form, which is substantially unchanged from the previous authorizing procedure, will be available on the Electronic Document Handling system (https://edh.cern.ch/) as of 1st September 2001. From this date use of the paper version should be discontinued.

  3. 19 CFR 142.24 - Special permit.

    Science.gov (United States)

    2010-04-01

    ... (CONTINUED) ENTRY PROCESS Special Permit for Immediate Delivery § 142.24 Special permit. (a) Conditions for issuance. At the discretion of the port director, a special permit for immediate delivery may be issued on... of a shipment of merchandise under a special permit for immediate delivery, the importer shall note a...

  4. PSD Permit Applications In Region 4

    Science.gov (United States)

    The following permits have been submitted to EPA Region 4 as Proposed Title V permits. While EPA has the right to a 45-day review period for all Proposed Title V permits, EPA Region 4 targets only a subset of these permits for comprehensive review.

  5. 50 CFR 13.27 - Permit suspension.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false Permit suspension. 13.27 Section 13.27... GENERAL PERMIT PROCEDURES Permit Administration § 13.27 Permit suspension. (a) Criteria for suspension... Government. Such suspension shall remain in effect until the issuing officer determines that the...

  6. Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization

    DEFF Research Database (Denmark)

    Scheel, Troels Kasper Høyer; Gottwein, Judith Margarete; Jensen, Tina Birk

    2008-01-01

    in serial passages. Sequence analysis of recovered viruses and subsequent reverse genetic studies revealed a vital dependence on one or two NS2 mutations, depending on the 4a/2a junction. Infectivity of ED43/JFH1 viruses was CD81 dependent. The genotype 4 cell culture systems permit functional analyses...

  7. Facing Title V permit constraints

    Energy Technology Data Exchange (ETDEWEB)

    Patankar, U.M. [JACA Corp., Fort Washington, PA (United States)

    1995-06-01

    The new Title V operating permit requirement under state regulations pursuant to the 1990 Clean Air Act Amendments will cover every emission source at a facility. These rules will significantly affect an operation by setting minimum compliance requirements, mandating periodic compliance certification, prescribing complex monitoring, record keeping and reporting procedures and making state and EPA approval of routine operational changes necessary through a permit amendment. The main concern with Title V is its effect on the operational flexibility of a facility, and individual emission sources within that facility. Unless properly addressed in a permit document, the term operational flexibility, so freely used by regulators in the context of the Title V program, can turn into a misnomer and the ability to operate as before may be significantly compromised under Title V. True operational flexibility is essential for businesses to respond to real changes in the marketplace. In the age of automation, just-in-time inventories and increased competition, flexibility to operate can mean the difference between growth and stagnation.

  8. Forest Products Industry Permitting Information

    Science.gov (United States)

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  9. Rosebud Casino and Hotel NPDES Proposed Permit

    Science.gov (United States)

    Indian Country, Minor Permit, proposed permit SD-0034584, Rosebud Casino and Hotel, South Dakota, is authorized to discharge from its wastewater treatment facility in Todd County, South Dakota to an unnamed drainageway(s) tributary to Rock Creek.

  10. Air Force Academy MS4 NPDES Permit

    Science.gov (United States)

    Under NPDES permit CO-R042007, the U.S. Air Force Academy is authorized to discharge from all municipal separate storm sewer system outfalls to the receiving waters specified in the permit in El Paso County, Colorado.

  11. 45 CFR 670.13 - Permit administration.

    Science.gov (United States)

    2010-10-01

    ... CONSERVATION OF ANTARCTIC ANIMALS AND PLANTS Permits § 670.13 Permit administration. (a) Issuance of the... U.S.C. 1531 et seq.) or any native bird which is protected under the Migratory Bird Treaty Act (16...

  12. Gulf of Mexico Shrimp Permit Landings Survey

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data set contains annual shrimp landings at the permit level from 2005-current fishing year. This also contains annual value of permit holders shrimp landings by...

  13. 36 CFR 13.112 - Permit revocation.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Permit revocation. 13.112... NATIONAL PARK SYSTEM UNITS IN ALASKA Cabins General Provisions § 13.112 Permit revocation. (a) The... request for a hearing concerning the revocation, based on the cause listed above, of a permit or...

  14. 50 CFR 21.41 - Depredation permits.

    Science.gov (United States)

    2010-10-01

    ... PLANTS (CONTINUED) MIGRATORY BIRD PERMITS Control of Depredating and Otherwise Injurious Birds § 21.41... control purposes. No permit is required merely to scare or herd depredating migratory birds other than... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Depredation permits. 21.41 Section 21.41...

  15. Permitting plan for Hanford tanks initiative

    Energy Technology Data Exchange (ETDEWEB)

    Bloom, J.W., Fluor Daniel Hanford

    1997-02-10

    This plan describes all the possible permitting actions that could be required to implement the Hanford Tanks Initiative Project (HTI). Since the HTI Project Plan has several decision points where possible future activities could be eliminated, not all permitting actions described will be implemented. The cost and schedule for the permitting actions are included.

  16. 36 CFR 13.188 - Permit terms.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Permit terms. 13.188 Section....188 Permit terms. The Superintendent shall allow for use and occupancy of a temporary facility only to... Superintendent may also establish permit terms that: (a) Limit use to a specified period, not to exceed...

  17. 36 CFR 13.164 - Permit terms.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Permit terms. 13.164 Section... PARK SYSTEM UNITS IN ALASKA Cabins Cabin Use for Subsistence Purposes § 13.164 Permit terms. The Superintendent shall, among other conditions, establish terms of a permit that: (a) Allow for use and...

  18. 78 FR 18420 - Special Permit Applications Actions

    Science.gov (United States)

    2013-03-26

    ... processing of, special permits from the Department of Transportation's Hazardous Material Regulations (49 CFR... permit S.P No. Applicant Regulation(s) thereof MODIFICATION SPECIAL PERMIT GRANTED 11470-M Veolia ES... Flanders, NJ. marking requirements. 15655-M Walt Disney Parks and 49 CFR 173.56(b) and To modify the...

  19. Protein kinase A-dependent step(s) in hepatitis C virus entry and infectivity.

    Science.gov (United States)

    Farquhar, Michelle J; Harris, Helen J; Diskar, Mandy; Jones, Sarah; Mee, Christopher J; Nielsen, Søren U; Brimacombe, Claire L; Molina, Sonia; Toms, Geoffrey L; Maurel, Patrick; Howl, John; Herberg, Friedrich W; van Ijzendoorn, Sven C D; Balfe, Peter; McKeating, Jane A

    2008-09-01

    Viruses exploit signaling pathways to their advantage during multiple stages of their life cycle. We demonstrate a role for protein kinase A (PKA) in the hepatitis C virus (HCV) life cycle. The inhibition of PKA with H89, cyclic AMP (cAMP) antagonists, or the protein kinase inhibitor peptide reduced HCV entry into Huh-7.5 hepatoma cells. Bioluminescence resonance energy transfer methodology allowed us to investigate the PKA isoform specificity of the cAMP antagonists in Huh-7.5 cells, suggesting a role for PKA type II in HCV internalization. Since viral entry is dependent on the host cell expression of CD81, scavenger receptor BI, and claudin-1 (CLDN1), we studied the role of PKA in regulating viral receptor localization by confocal imaging and fluorescence resonance energy transfer (FRET) analysis. Inhibiting PKA activity in Huh-7.5 cells induced a reorganization of CLDN1 from the plasma membrane to an intracellular vesicular location(s) and disrupted FRET between CLDN1 and CD81, demonstrating the importance of CLDN1 expression at the plasma membrane for viral receptor activity. Inhibiting PKA activity in Huh-7.5 cells reduced the infectivity of extracellular virus without modulating the level of cell-free HCV RNA, suggesting that particle secretion was not affected but that specific infectivity was reduced. Viral particles released from H89-treated cells displayed the same range of buoyant densities as did those from control cells, suggesting that viral protein association with lipoproteins is not regulated by PKA. HCV infection of Huh-7.5 cells increased cAMP levels and phosphorylated PKA substrates, supporting a model where infection activates PKA in a cAMP-dependent manner to promote virus release and transmission.

  20. Federal Environmental Permitting Handbook. Environmental Guidance

    Energy Technology Data Exchange (ETDEWEB)

    1991-05-01

    The handbook consists of eight chapters addressing permitting and licensing requirements under the Resource Conservation and Recovery Act (RCRA), the Comprehensive Environmental Response, Compensation, and Liability Act of 1980, as amended by the Superfund Amendments and Reauthorization Act of 1986 (CERCLA/SARA), the Atomic Energy Act (AEA), the Clean Air Act (CAA), the Clean Water Act (CWA), the Federal Insectide, Fungicide, and Rodenticide Act (FIFRA), the Safe Drinking Water Act (SDWA), and the Toxic Substances Control Act (TSCA). Each chapter consists of: (1) an introduction to the statute and permitting requirements; (2) a diagram illustrating the relationship between permitting requirements under the statute being discussed and permitting requirements from other environmental statutes which may have to be addressed when applying for a particular permit (e.g., when applying for a RCRA permit, permits and permit applications under the CWA, CAA, SDWA, etc. would have to be listed in the RCRA permit application); and, (3) a compilation of the permitting requirements for the regulatory program resulting from the statute. In addition, the Handbook contains a permitting keyword index and a listing of hotline telephone numbers for each of the statutes.

  1. Annual Hanford Site Environmental Permitting status report

    Energy Technology Data Exchange (ETDEWEB)

    SONNICHSEN, J.C.

    1999-10-18

    The information contained in, and/or referenced in, this Annual Hanford Site Environmental Permitting Status Report addresses Permit Condition II.W (Other Permits and/or Approvals) of the Dangerous Waste Portion of the Resource Conservation and Recovery Act Permit for the Treatment, Storage, and Disposal of Dangerous Waste, issued by the Washington State Department of Ecology (WA7890008967). Condition II.W specifies that the Permittees are responsible for obtaining all other applicable federal, state, and local permits authorizing the development and operation of the Hanford Facility. Condition II.W further specifies that the Permittees are to use their best efforts to obtain such permits. For the purposes of this Permit Condition, ''best efforts'' mean submittal of documentation and/or approval(s) in accordance with schedules specified in applicable regulations, or as determined through negotiations with the applicable regulatory agencies.

  2. Annual Hanford Site Environmental Permitting Status Report

    Energy Technology Data Exchange (ETDEWEB)

    HOMAN, N.A.

    2000-10-01

    The information contained in, and/or referenced in, this Annual Hanford Site Environmental Permitting Status Report addresses Permit Condition II.W (Other Permits and/or Approvals) of the Dangerous Waste Portion of the Resource Conservation and Recovery Act Permit for the Treatment, Storage, and Disposal of Dangerous Waste, issued by the Washington State Department of Ecology (WA7890008967). Condition II.W specifies that the Permittees are responsible for obtaining all other applicable federal, state, and local permits authorizing the development and operation of the Hanford Facility. This status report also addresses Permit Condition I.E.22, as interpreted in Section 12.1.25 of the Hanford Facility Dangerous Waste Permit Application, General Information Portion (DOE/RL-91-28, Rev. 4), that states this report will be prepared annually and a copy of this report will be placed in the Facility Operating Record, General Information file by October 1 of each year.

  3. 40 CFR 124.9 - Administrative record for draft permits when EPA is the permitting authority.

    Science.gov (United States)

    2010-07-01

    ....9 Administrative record for draft permits when EPA is the permitting authority. (a) The provisions... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Administrative record for draft permits when EPA is the permitting authority. 124.9 Section 124.9 Protection of Environment...

  4. 40 CFR 124.18 - Administrative record for final permit when EPA is the permitting authority.

    Science.gov (United States)

    2010-07-01

    ....18 Administrative record for final permit when EPA is the permitting authority. (a) The Regional... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Administrative record for final permit when EPA is the permitting authority. 124.18 Section 124.18 Protection of Environment...

  5. EPA Region 2 Discharge Pipes for Facilites with NPDES Permits from the Permit Compliance GIS Layer

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Permit and Compliance System (PCS) contains data on the National Pollution Discharge Elimination Systems (NPDES) permit-holding facilities. This includes...

  6. Building Permits, permits plus data base, Published in 2006, Washoe County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Building Permits dataset, was produced all or in part from Published Reports/Deeds information as of 2006. It is described as 'permits plus data base'. Data by...

  7. Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE

    NARCIS (Netherlands)

    Dijkstra, S.; Kooij, G.; Verbeek, R.; Pol, S.M.A. van der; Amor, S.; Geisert Jr., E.E.; Dijkstra, C.D.; Noort, J.M. van; Vries, H.E.d.

    2008-01-01

    Leukocyte infiltration is a key step in the development of demyelinating lesions in multiple sclerosis (MS), and molecules mediating leukocyte-endothelial interactions represent prime candidates for the development of therapeutic strategies. Here we studied the effects of blocking the integrin-assoc

  8. 19 CFR 10.61 - Withdrawal permit.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Withdrawal permit. 10.61 Section 10.61 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY... bond, when required, the port director shall issue a permit on Customs Form 7501 or 7512....

  9. Dielectric permitivity measurement of cotton lint

    Science.gov (United States)

    A technique was developed for making broad band measurements of cotton lint electrical permitivity. The fundamental electrical permitivity value of cotton lint at various densities and moisture contents; is beneficial for the future development of cotton moisture sensors as it provides a...

  10. 75 FR 54649 - Endangered Wildlife; Permits

    Science.gov (United States)

    2010-09-08

    ... Fish and Wildlife Service Endangered Wildlife; Permits AGENCY: Fish and Wildlife Service, Interior... Wildlife Service (Service), invite the public to comment on applications for permits to conduct enhancement..., U.S. Fish and Wildlife Service, 911 NE. 11th Avenue, Portland, OR 97232-4181. FOR...

  11. 45 CFR 3.24 - Parking permits.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Parking permits. 3.24 Section 3.24 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CONDUCT OF PERSONS AND TRAFFIC ON THE NATIONAL..., a person may not park a motor vehicle without displaying a parking permit, currently valid for...

  12. 32 CFR 552.90 - Permit office.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Permit office. 552.90 Section 552.90 National... CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Fort Lewis Land Use Policy § 552.90 Permit office... non-training acess to the range complex. The office is open 0700-1900 hours, seven days a week,...

  13. 78 FR 36822 - Special Permit Applications

    Science.gov (United States)

    2013-06-19

    ... Pipeline and Hazardous Materials Safety Administration Special Permit Applications AGENCY: Pipeline And... Applications. SUMMARY: In accordance with the procedures governing the application for, and the processing of..., Subpart B), notice is hereby given of the actions on special permits applications in (May to May 2013...

  14. 9 CFR 104.3 - Permit application.

    Science.gov (United States)

    2010-01-01

    ....3 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PERMITS FOR BIOLOGICAL PRODUCTS § 104.3 Permit application. (a) Each person desiring to import a biological product shall make...

  15. Permitting plan for Hanford Tanks Initiative

    Energy Technology Data Exchange (ETDEWEB)

    Bloom, J.W.

    1998-03-19

    This plan describes all the permitting actions that have been identified as required to implement the Hanford Tanks Initiative. It reflects changes in the scope to the Hanford Tanks Initiative since the Rev. 0 plan was issued. The cost and schedule for the permitting actions are included.

  16. 30 CFR 740.13 - Permits.

    Science.gov (United States)

    2010-07-01

    ... necessary to support surface coal mining and reclamation operations. (B) An evaluation of impacts to the... regulatory authority has not yet rendered a final decision with respect to the permit application; and (iii... lands administered by a Federal land management agency. Upon receipt of a permit application package...

  17. 78 FR 43268 - Special Permit Applications

    Science.gov (United States)

    2013-07-19

    ... hazardous material. (modes 1, 2, 3, 4) 15860-N......... Apple Inc. 49 CFR To authorize the Cupertino, CA... modify the Inc. Baton 173.306(a)(3). special permit to Rouge, LA. reflect current statutes and... modify the Technologies special permit to Inc. (Former change a drawing Grantee: Conax number;...

  18. Annual Hanford Site environmental permitting status report

    Energy Technology Data Exchange (ETDEWEB)

    Sonnichsen, J.C.

    1998-09-17

    The information contained and/or referenced in this Annual Hanford Site Environmental Permitting Status Report (Status Report) addresses the State Environmental Policy Act (SEPA) of 1971 and Condition II.W. of the Resource Conservation and Recovery Act (RCRA) of 1976 Permit, Dangerous Waste Portion (DW Portion). Condition II.W. of the RCRA Permit specifies the Permittees are responsible for all other applicable federal, state, and local permits for the development and operation of the Hanford Facility. Condition II.W. of the RCRA Permit specifies that the Permittees are to use their best efforts to obtain such permits. For the purposes of permit condition, `best efforts` means submittal of documentation and/or approval(s) in accordance with schedules specified in applicable regulations, or as determined through negotiations with the applicable regulatory agencies. This Status Report includes information on all existing and anticipated environmental permitting. Environmental permitting required by RCRA, the Hazardous and Solid Waste Amendments (HSWA) of 1984, and non-RCRA permitting (solid waste handling, Clean Air Act Amendments of 1990, Clean Water Act Amendments of 1987, Washington State waste discharge, and onsite sewage system) is addressed. Information on RCRA and non-RCRA is current as of July 31, 1998. For the purposes of RCRA and the State of Washington Hazardous Waste Management Act of 1976 [as administered through the Dangerous Waste Regulations, Washington Active Code (WAC) 173-303], the Hanford Facility is considered a single facility. As such, the Hanford Facility has been issued one US Environmental Protection Agency (EPA)/State Identification Number (WA7890008967). This EPA/State identification number encompasses over 60 treatment, storage, and/or disposal (TSD) units. The Washington State Department of Ecology (Ecology) has been delegated authority by the EPA to administer the RCRA, including mixed waste authority. The RCRA permitting approach for

  19. 78 FR 72830 - Migratory Bird Permits; Delegating Falconry Permitting Authority to 17 States

    Science.gov (United States)

    2013-12-04

    ... Permitting Authority to 17 States AGENCY: Fish and Wildlife Service, Interior. ACTION: Final rule. SUMMARY... have requested that we delegate permitting for falconry to the State, as provided under our regulations... relevant regulation at 50 CFR 21.29 governing the transfer of permitting authority to these States has...

  20. 50 CFR 18.31 - Scientific research permits and public display permits.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Scientific research permits and public... Scientific research permits and public display permits. The Director may, upon receipt of an application and... importation of marine mammals for scientific research purposes or for public display. (a) Application...

  1. 77 FR 22267 - Eagle Permits; Changes in the Regulations Governing Eagle Permitting

    Science.gov (United States)

    2012-04-13

    ... Fish and Wildlife Service 50 CFR Parts 13 and 22 RIN 1018-AX91 Eagle Permits; Changes in the Regulations Governing Eagle Permitting AGENCY: Fish and Wildlife Service, Interior. ACTION: Proposed rule. SUMMARY: We propose to revise the regulations for permits for nonpurposeful take of golden eagles...

  2. 77 FR 27174 - Eagle Permits; Changes in the Regulations Governing Eagle Permitting

    Science.gov (United States)

    2012-05-09

    ... Fish and Wildlife Service 50 CFR Parts 13 and 22 RIN 1018-AX91 Eagle Permits; Changes in the Regulations Governing Eagle Permitting AGENCY: Fish and Wildlife Service, Interior. ACTION: Proposed rule... 13, 2012, proposed rule to revise the regulations for permits for nonpurposeful take of golden...

  3. Ships Docked at Title V Permitted Facilities

    Science.gov (United States)

    This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  4. Gulf of Mexico Shrimp Permit Gear Survey

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data set contains annual vessel gear characterization of permit holders shrimp vessel. Data includes net type, TED type, BRD type, etc.

  5. 40 CFR 71.9 - Permit fees.

    Science.gov (United States)

    2010-07-01

    ... the Consumer Price Index. (2) Part 71 permit program costs and fees will be reviewed by the... Administrator, the changes will be published in the Federal Register. (o) Use of revenue. All fees,...

  6. 2011 EPA Pesticide General Permit (PGP)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The 2011 EPA Pesticide General Permit (PGP) covers discharges of biological pesticides, and chemical pesticides that leave a residue, in areas where EPA is the NPDES...

  7. 2013 EPA Vessels General Permit (VGP)

    Data.gov (United States)

    U.S. Environmental Protection Agency — Information for any vessel that submitted a Notice of Intent (NOI), Notice of Termination (NOT), or annual report under EPA's 2013 Vessel General Permit (VGP)....

  8. Cheyenne Mountain Air Force Station NPDES Permit

    Science.gov (United States)

    Under NPDES permit CO-0034762, the Cheyenne Mountain Air Force Station is authorized to discharge from the interior storm drainage system and air exhaust stacks at the Cheyenne Mountain Complex, in El Paso County, Colorado, to tributaries Fountain Creek.

  9. Storm Water General Permit 2 for Construction

    Data.gov (United States)

    Iowa State University GIS Support and Research Facility — General permit #2 for storm water discharges associated with industrial activity for Construction Activities in Iowa for the National Pollutant Discharge Elimination...

  10. Rosebud Casino and Hotel NPDES Permit

    Science.gov (United States)

    Under NPDES permit SD-0034584, Rosebud Casino and Hotel, South Dakota, is authorized to discharge from its wastewater treatment facility in Todd County, South Dakota to an unnamed drainageway(s) tributary to Rock Creek.

  11. Crow Nation Water Treatment Plant NPDES Permit

    Science.gov (United States)

    Under NPDES permit MT-0030538, the U.S. Bureau of Indian Affairs is authorized to discharge from the Crow Agency water treatment plants via the wastewater treatment facility located in Bighorn County, Montana to the Little Bighorn River.

  12. Absaloka Mine South Extension NPDES Permit

    Science.gov (United States)

    Under NPDES permit MT-0030783, Westmoreland Resources, Inc. is authorized to discharge mine drainage from outfalls associated with the Absaloka Mine South Extension on the Crow Indian reservation near Hardin, Montana to Middle Fork of Sarpy Creek.

  13. 75 FR 2560 - Issuance of Permits

    Science.gov (United States)

    2010-01-15

    ...) the application was filed in good faith, (2) the granted permit would not operate to the disadvantage... County 74 FR 46222, September December 17, 2009 Zoo. 8, 2009. 225871 Lorenzo J. Ferraro..... 74 FR...

  14. 40 CFR 233.21 - General permits.

    Science.gov (United States)

    2010-07-01

    ... apply for an individual permit. This discretionary authority will be based on concerns for the aquatic... the discharger of his decision to exercise discretionary authority to require an individual...

  15. 77 FR 4271 - Special Permit Marking Removal

    Science.gov (United States)

    2012-01-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION... Administration (FRA), Department of Transportation (DOT). ACTION: Removal of obsolete Special Permit markings... first shopping event, whichever occurred first. This document relieves tank car owners from that...

  16. Web Air Permits (WAP R7)

    Data.gov (United States)

    U.S. Environmental Protection Agency — THIS DATA ASSET NO LONGER ACTIVE: This is metadata documentation for Web Air Permits in Region 7 (WAP R7), a Lotus Notes application that once tracked comment...

  17. Permit Review - Florida Gas Transmission Company (FGT)

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Branch of Air Quality Permit Review for Florida Gas Transmission Company and their expansion of Compressor Station Number 10 in Wiggins, Mississippi. The facility is...

  18. MicroRNA-155 in exosomes secreted from helicobacter pylori infection macrophages immunomodulates inflammatory response

    Science.gov (United States)

    Wang, Jianjun; Deng, Zhiyong; Wang, Zeyou; Wu, Jianhong; Gu, Tao; Jiang, Yibiao; Li, Guangxin

    2016-01-01

    Exosomes containing microRNA-155 act as molecule carriers during immune cell-cell communication and play an important role in the inflammatory response of H. pylori infection macrophages. Previous reports have found that miR-155 was over-expressed in H. pylori infection macrophages, but the significance of which is still unknown. In this study, we analyzed the impact of miR-155 loaded in exosomes derived from macrophages to the inflammatory response of H. pylori infection macrophages and possible mechanisms. We found that miR-155 promoted the expression of inflammatory cytokines including TNF-a, IL-6, IL-23, but also increased the expression of CD40, CD63, CD81, and MCH-I. Meanwhile, inflammatory signal pathways proteins, such as MyD88, NF-κB in H. pylori infection macrophages were down-regulated due to the over-expression of miR-155. Experiments in vitro or in vivo revealed that miR-155 promoted macrophages to inhibit or kill H. pylori by regulating the inflammatory response of cells to prevent the gastritis caused by H. pylori infection. These findings contribute to the understanding of miR-155 contained in exosomes in inflammatory responses of H. pylori infection macrophages. PMID:27725852

  19. 30 CFR 773.10 - Review of permit history.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Review of permit history. 773.10 Section 773.10... REQUIREMENTS FOR PERMITS AND PERMIT PROCESSING § 773.10 Review of permit history. (a) We, the regulatory authority, will rely upon the permit history information you, the applicant, submit under § 778.12 of this...

  20. 9 CFR 78.2 - Handling of certificates, permits, and “S” brand permits for interstate movement of animals.

    Science.gov (United States)

    2010-01-01

    ... âSâ brand permits for interstate movement of animals. 78.2 Section 78.2 Animals and Animal Products... certificates, permits, and “S” brand permits for interstate movement of animals. (a) Any certificate, permit, or “S” brand permit required by this part for the interstate movement of animals shall be...

  1. IFQ Halibut/Sablefish and CDQ Halibut Permit Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Under the IFQ Halibut/Sablefish Permit Program and CDQ Halibut Permit Program permits are issued for harvesting and receiving/processing halibut, and non-trawl...

  2. State Waste Discharge Permit ST-4502 Implementation Plan

    Energy Technology Data Exchange (ETDEWEB)

    BROWN, M.J.; LECLAIR, M.D.

    2000-09-27

    Plan has been developed to demonstrate compliance with regulatory requirements set forth in Permit ST-3502 and as a line management tool for use in maintaining configuration control of permit as well as documentation used to implement permit requirements.

  3. The cell biology of cryptosporidium infection.

    Science.gov (United States)

    O'Hara, Steven P; Chen, Xian-Ming

    2011-08-01

    Cryptosporidiosis remains a significant cause of enteric disease worldwide. Basic investigations of host: pathogen interactions have revealed the intricate processes mediating infection. The following summarizes the interactions that mediate infection and the host responses that both permit and ultimately clear the infection.

  4. 78 FR 21146 - Endangered and Threatened Species Permit Applications

    Science.gov (United States)

    2013-04-09

    .... 552). Permit TE-98707A Applicant: Mitchell Lockhart, Sallisaw, Oklahoma. Applicant requests a new... Zoo and Aquarium. Permit TE-00347B Applicant: Alisha Powell, Sallisaw, Oklahoma. Applicant requests...

  5. A Novel Human Radixin Peptide Inhibits Hepatitis C Virus Infection at the Level of Cell Entry.

    Science.gov (United States)

    Bukong, Terence N; Kodys, Karen; Szabo, Gyongyi

    2014-09-01

    Hepatitis C virus infection of hepatocytes is a multistep process involving the interaction between viral and host cell molecules. Recently, we identified ezrin-moesin-radixin proteins and spleen tyrosine kinase (SYK) as important host therapeutic targets for HCV treatment development. Previously, an ezrin hinge region peptide (Hep1) has been shown to exert anti-HCV properties in vivo, though its mechanism of action remains limited. In search of potential novel inhibitors of HCV infection and their functional mechanism we analyzed the anti-HCV properties of different human derived radixin peptides. Sixteen different radixin peptides were derived, synthesized and tested. Real-time quantitative PCR, cell toxicity assay, immuno-precipitation/western blot analysis and computational resource for drug discovery software were used for experimental analysis. We found that a human radixin hinge region peptide (Peptide1) can specifically block HCV J6/JFH-1 infection of Huh7.5 cells. Peptide 1 had no cell toxicity or intracellular uptake into Huh7.5 cells. Mechanistically, the anti-HCV activity of Peptide 1 extended to disruption of HCV engagement of CD81 thereby blocking downstream SYK activation, which we have recently demonstrated to be important for effective HCV infection of target hepatocytes. Our findings highlight a novel functional class of anti-HCV agents that can inhibit HCV infection, most likely by disrupting vital viral-host signaling interactions at the level of virus entry.

  6. Hanford facility dangerous waste permit application

    Energy Technology Data Exchange (ETDEWEB)

    None

    1991-09-18

    This document, Set 2, the Hanford Facility Dangerous Waste Part B Permit Application, consists of 15 chapters that address the content of the Part B checklists prepared by the Washington State Department of Ecology (Ecology 1987) and the US Environmental Protection Agency (40 CFR 270), with additional information requirements mandated by the Hazardous and Solid Waste Amendments of 1984 and revisions of WAC 173-303. For ease of reference, the Washington State Department of Ecology checklist section numbers, in brackets, follow the chapter headings and subheadings. This permit application contains umbrella- type'' documentation with overall application to the Hanford Facility. This documentation is broad in nature and applies to all TSD units that have final status under the Hanford Facility Permit.

  7. 77 FR 66406 - Migratory Bird Permits; Delegating Falconry Permitting Authority to Seven States

    Science.gov (United States)

    2012-11-05

    ... significant economic impact on a substantial number of small entities. This rule delegates authority to States... Permitting Authority to Seven States AGENCY: Fish and Wildlife Service, Interior. ACTION: Final rule. SUMMARY... requested that we delegate permitting for falconry to the State, as provided under our regulations. We have...

  8. 76 FR 71910 - Migratory Bird Permits; States Delegated Falconry Permitting Authority; Technical Corrections to...

    Science.gov (United States)

    2011-11-21

    ... number of small entities. This rule delegates authority to States that have requested it, and those... Falconry Permitting Authority; Technical Corrections to the Regulations AGENCY: Fish and Wildlife Service... Carolina, Ohio, Oregon, Tennessee, Virginia, and Wyoming have requested that we delegate permitting for...

  9. 30 CFR 947.773 - Requirements for permits and permit processing.

    Science.gov (United States)

    2010-07-01

    ... control structures, roads, and other significant features contained in the application marked by flags. (c... regulations: (1) Department of Ecology: Surface Water Rights Permit, RCW 90.03.250 Dam Safety Approval, RCW 90....03.380 Ground Water Permit, RCW 90.44.050 New Source Construction Approval, RCW 79.94.152...

  10. Residential Parking Permits and Parking Supply

    NARCIS (Netherlands)

    J. van Ommeren (Jos); J. de Groote (Jesper); G. Mingardo (Giuliano)

    2013-01-01

    textabstractWe estimate welfare losses of policies that provide on-street parking permits to residents almost free of charge in shopping districts. Our empirical results indicate that parking supply is far from perfectly price elastic, implying that there are substantial welfare losses related to un

  11. 36 CFR 13.162 - Permit issuance.

    Science.gov (United States)

    2010-07-01

    ...) In making a decision on a permit application, the Superintendent shall consider whether the use by local rural residents of a cabin or other structure for subsistence purposes is customary and... structure is “necessary to reasonably accommodate” the applicant's subsistence uses. In making...

  12. Permitting of Wind Energy Facilities: A Handbook

    Energy Technology Data Exchange (ETDEWEB)

    NWCC Siting Work Group

    2002-08-01

    This handbook has been written for individuals and groups involved in evaluating wind projects: decision-makers and agency staff at all levels of government, wind developers, interested parties and the public. Its purpose is to help stakeholders make permitting wind facility decisions in a manner which assures necessary environmental protection and responds to public needs.

  13. 27 CFR 22.24 - Permits.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Permits. 22.24 Section 22.24 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS DISTRIBUTION AND USE OF TAX-FREE ALCOHOL Administrative Provisions Authorities §...

  14. 27 CFR 20.25 - Permits.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Permits. 20.25 Section 20.25 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS DISTRIBUTION AND USE OF DENATURED ALCOHOL AND RUM Administrative Provisions...

  15. Standing Rock Rural Water System NPDES Permit

    Science.gov (United States)

    Under NPDES permit SD-0030996, the Standing Rock Rural Water System is authorized to discharge from its wastewater treatment facility in Corson County, South Dakota, to an unnamed tributary to Fisher Creek, a tributary to Oahe Reservoir on the Missouri R.

  16. 75 FR 41233 - Issuance of Permits

    Science.gov (United States)

    2010-07-15

    ... application was filed in good faith, (2) the granted permit would not operate to the disadvantage of the... 62586; November April 01, 2010 Mexico, Museum of 30, 2009. Southwestern Biology. 08939A Los Angeles Zoo... University of 16, 2009. California at Berkeley. 228022 Metro Richmond Zoo..... 75 FR 427; January 5, April...

  17. 75 FR 12564 - Issuance of Permits

    Science.gov (United States)

    2010-03-16

    ...) the application was filed in good faith, (2) the granted permit would not operate to the disadvantage..., 2009 16, 2009. 220887 Fort Worth Zoo 74 FR 55062; October February 19, 2010 26, 2009. 223400 Earth... Zoo 74 FR 66675; December February 2, 2010 16, 2009. 231594 Seneca Park Zoo 74 FR 58977;...

  18. 40 CFR 71.25 - Permit content.

    Science.gov (United States)

    2010-07-01

    ... of an emergency. An emergency constitutes an affirmative defense to an action brought for... such deviations and any corrective actions or preventive measures taken. The Administrator will define... requirements in the event of a challenge to any portions of the permit. (7) Provisions stating the...

  19. 50 CFR 665.203 - Permits.

    Science.gov (United States)

    2010-10-01

    .... If one or more persons on a vessel-based bottomfish fishing trip holds an MHI non-commercial permit... fishing occurs during or as a result of a vessel-based fishing trip, then the fishing trip is considered... incapacitation, vessel breakdowns, and the loss of the vessel at sea if the event prevented the vessel...

  20. 50 CFR 660.25 - Permits.

    Science.gov (United States)

    2010-10-01

    ..., accumulation limits, fees, and appeals are described at § 660.150, subpart D. (vi) C/P endorsement. A C/P... of permit ownership, accumulation limits, fees, and appeals are described at § 660.140, subpart D. (d... receiver to receive, purchase, or take custody, control or possession of landings from the Shorebased...

  1. 43 CFR 36.9 - Issuing permit.

    Science.gov (United States)

    2010-10-01

    ... purposes for which the affected area was established or is managed; (2) Requirements for restoration.... (5) Requirements to protect the interests of individuals living in the general area of the right-of-way permit who rely on the fish, wildlife and biotic resources of the area for subsistence...

  2. 30 CFR 773.17 - Permit conditions.

    Science.gov (United States)

    2010-07-01

    .... (e) The permittee shall take all possible steps to minimize any adverse impact to the environment or... Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR SURFACE COAL MINING AND RECLAMATION OPERATIONS PERMITS AND COAL EXPLORATION SYSTEMS UNDER REGULATORY...

  3. 9 CFR 104.1 - Permit required.

    Science.gov (United States)

    2010-01-01

    ... Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PERMITS FOR BIOLOGICAL PRODUCTS § 104.1... biological product into the United States shall be issued in accordance with the regulations in this part....

  4. 77 FR 10183 - Reissuance of Nationwide Permits

    Science.gov (United States)

    2012-02-21

    ..., 2011, issue of the Federal Register (76 FR 9174), the U.S. Army Corps of Engineers (Corps) published... adopted the concept of general permits in its final rule published on July 25, 1975 (see 40 FR 31321). The... specific activities or situations that are not authorized, or for which a PCN is required to allow...

  5. 50 CFR 679.4 - Permits.

    Science.gov (United States)

    2010-10-01

    ... permits—(1) Operators of commercial fishing vessels using power troll gear. The operator of a fishing vessel using power troll gear may engage in commercial fishing for salmon in the Salmon Management Area if the operator: (i) Held a valid State of Alaska power troll permanent entry permit on May 15,...

  6. 50 CFR 648.4 - Vessel permits.

    Science.gov (United States)

    2010-10-01

    ... apply for a IFQ scallop permit who disputes NMFS's determination of the vessel's contribution factor... is in the process of construction or rerigging or under agreement or written contract for construction or rerigging, as of the effective baseline specification date in which case the baseline...

  7. 9 CFR 122.2 - Permits required.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Permits required. 122.2 Section 122.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES... Office of Management and Budget under control number 0579-0015)...

  8. 75 FR 44987 - Issuance of Permits

    Science.gov (United States)

    2010-07-30

    ... [Federal Register Volume 75, Number 146 (Friday, July 30, 2010)] [Notices] [Pages 44987-44988] [FR Doc No: 2010-18754] DEPARTMENT OF THE INTERIOR Fish and Wildlife Service [FWS-R9-IA-2010-N153] [96300-1671-0000-P5] Issuance of Permits AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice...

  9. Renewable Energy Permitting Barriers in Hawaii: Experience from the Field

    Energy Technology Data Exchange (ETDEWEB)

    Busche, S.; Donnelly, C.; Atkins, D.; Fields, R.; Black, C.

    2013-03-01

    This white paper presents a summary of the solicited input from permitting agencies and renewable energy developers on the permitting process in Hawaii to provide stakeholders in Hawaii, particularly those involved in permitting, with information on current permitting barriers that renewable energy developers are experiencing.

  10. 40 CFR 270.60 - Permits by rule.

    Science.gov (United States)

    2010-07-01

    ... treatment works. The owner or operator of a POTW which accepts for treatment hazardous waste, if the owner... ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Special Forms of Permits § 270.60 Permits by... operator of a barge or other vessel which accepts hazardous waste for ocean disposal, if the owner or...

  11. 14 CFR 437.9 - Issuance of an experimental permit.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Issuance of an experimental permit. 437.9..., DEPARTMENT OF TRANSPORTATION LICENSING EXPERIMENTAL PERMITS General Information § 437.9 Issuance of an experimental permit. The FAA issues an experimental permit authorizing an unlimited number of launches...

  12. 14 CFR 437.7 - Scope of an experimental permit.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Scope of an experimental permit. 437.7..., DEPARTMENT OF TRANSPORTATION LICENSING EXPERIMENTAL PERMITS General Information § 437.7 Scope of an experimental permit. An experimental permit authorizes launch or reentry of a reusable suborbital rocket....

  13. 14 CFR 437.5 - Eligibility for an experimental permit.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Eligibility for an experimental permit. 437... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING EXPERIMENTAL PERMITS General Information § 437.5 Eligibility for an experimental permit. The FAA will issue an experimental permit to a person to launch...

  14. 14 CFR 437.83 - Compliance with experimental permit.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Compliance with experimental permit. 437.83..., DEPARTMENT OF TRANSPORTATION LICENSING EXPERIMENTAL PERMITS Terms and Conditions of an Experimental Permit § 437.83 Compliance with experimental permit. A permittee must conduct any launch or reentry under...

  15. 14 CFR 437.11 - Duration of an experimental permit.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Duration of an experimental permit. 437.11..., DEPARTMENT OF TRANSPORTATION LICENSING EXPERIMENTAL PERMITS General Information § 437.11 Duration of an experimental permit. An experimental permit lasts for one year from the date it is issued. A permittee...

  16. 14 CFR 437.15 - Transfer of an experimental permit.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Transfer of an experimental permit. 437.15..., DEPARTMENT OF TRANSPORTATION LICENSING EXPERIMENTAL PERMITS General Information § 437.15 Transfer of an experimental permit. An experimental permit is not transferable....

  17. 50 CFR 15.24 - Permits for cooperative breeding.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false Permits for cooperative breeding. 15.24... PLANTS WILD BIRD CONSERVATION ACT Permits and Approval of Cooperative Breeding Programs § 15.24 Permits for cooperative breeding. (a) Application requirements for permits for cooperative breeding....

  18. 40 CFR 124.41 - Definitions applicable to PSD permits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Definitions applicable to PSD permits... PROGRAMS PROCEDURES FOR DECISIONMAKING Specific Procedures Applicable to PSD Permits § 124.41 Definitions applicable to PSD permits. Whenever PSD permits are processed under this part, the following terms shall have...

  19. 50 CFR 648.88 - Multispecies open access permit restrictions.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Multispecies open access permit... Management Measures for the NE Multispecies and Monkfish Fisheries § 648.88 Multispecies open access permit restrictions. (a) Handgear permit. A vessel issued a valid open access NE multispecies Handgear permit...

  20. Building Permits, Buidling permits pulled from apprasial database and geocoded to loctions for all types of permits issued, Published in unknown, Johnson County AIMS.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Building Permits dataset, was produced all or in part from Published Reports/Deeds information as of unknown. It is described as 'Buidling permits pulled from...

  1. 78 FR 73704 - Eagle Permits; Changes in the Regulations Governing Eagle Permitting

    Science.gov (United States)

    2013-12-09

    ... sufficient to offset the estimated costs associated with working with the applicants to develop site plans... protocols for testing their effectiveness. The Service anticipates limiting costs associated with studying... for working with applicants, assessing permit applications, and undertaking monitoring associated...

  2. Should Advertising by Aesthetic Surgeons be Permitted?

    Science.gov (United States)

    Nagpal, Neeraj

    2017-01-01

    Cosmetic, aesthetic and cutaneous surgical procedures require qualified specialists trained in the various procedures and competent to handle complications. However, it also requires huge investments in terms of infrastructure, trained staff and equipment. To be viable advertising is essential to any establishment which provides cosmetic and aesthetic procedures. Business men with deep pockets establish beauty chains which also provide these services and advertise heavily to sway public opinion in their favour. However, these saloons and spas lack basic medical facilities in terms of staff or equipment to handle any complication or medical emergency. To have a level playing field ethical advertising should be permitted to qualified aesthetic surgeons as is permitted in the US and UK by their respective organisations. PMID:28529421

  3. Hanford Site air operating permit application

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-05-01

    The Clean Air Act Amendments of 1990, which amended the Federal Clean Air Act of 1977, required that the US Environmental Protection Agency develop a national Air Operating Permit Program, which in turn would require each state to develop an Air Operating Permit Program to identify all sources of ``regulated`` pollutants. Regulated pollutants include ``criteria`` pollutants (oxides of nitrogen, sulfur oxides, total suspended particulates, carbon monoxide, particulate matter greater than 10 micron, lead) plus 189 other ``Hazardous`` Air Pollutants. The Hanford Site, owned by the US Government and operated by the US Department of Energy, Richland Operations Office, is located in southcentral Washington State and covers 560 square miles of semi-arid shrub and grasslands located just north of the confluence of the Snake and Yakima Rivers with the Columbia River. This land, with restricted public access, provides a buffer for the smaller areas historically used for the production of nuclear materials, waste storage, and waste disposal. About 6 percent of the land area has been disturbed and is actively used. The Hanford Site Air Operating Permit Application consists of more than 1,100 sources and in excess of 300 emission points. Before January 1995, the maintenance and operations contractor and the environmental restoration contractor for the US Department of Energy completed an air emission inventory on the Hanford Site. The inventory has been entered into a database so that the sources and emission points can be tracked and updated information readily can be retrieved. The Hanford Site Air Operating Permit Application contains information current as of April 19, 1995.

  4. Hepatitis C virus (HCV infection may elicit neutralizing antibodies targeting epitopes conserved in all viral genotypes.

    Directory of Open Access Journals (Sweden)

    Nicasio Mancini

    Full Text Available Anti-hepatitis C virus (HCV cross-neutralizing human monoclonal antibodies, directed against conserved epitopes on surface E2 glycoprotein, are central tools for understanding virus-host interplay, and for planning strategies for prevention and treatment of this infection. Recently, we developed a research aimed at identifying these antibody specificities. The characteristics of one of these antibodies (Fab e20 were addressed in this study. Firstly, using immunofluorescence and FACS analysis of cells expressing envelope HCV glycoproteins, Fab e20 was able to recognize all HCV genotypes. Secondly, competition assays with a panel of mouse and rat monoclonals, and alanine scanning mutagenesis analyses located the e20 epitope within the CD81 binding site, documenting that three highly conserved HCV/E2 residues (W529, G530 and D535 are critical for e20 binding. Finally, a strong neutralizing activity against HCV pseudoparticles (HCVpp incorporating envelope glycoproteins of genotypes 1a, 1b, 2a, 2b and 4, and against the cell culture-grown (HCVcc JFH1 strain, was observed. The data highlight that neutralizing antibodies against HCV epitopes present in all HCV genotypes are elicited during natural infection. Their availability may open new avenues to the understanding of HCV persistence and to the development of strategies for the immune control of this infection.

  5. PERMITTING LEADERSHIP IN THE UNITED STATES

    Energy Technology Data Exchange (ETDEWEB)

    Ken Nemeth

    2002-09-01

    In accordance with the Southern States Energy Board (SSEB) proposal, as incorporated into NETL/DE-FC26-97FT34199, the objective of this agreement is to streamline the environmental technology permitting process site-to-site, state-to-state, and industry-to-industry to achieve remediation and waste processing faster, better and cheaper. SSEB is working with member Governors, legislators and regulators to build consensus on streamlining the permitting process for new and innovative technologies for addressing the legacy of environmental problems from 50 years of weapons research, development and production. This report reviews mechanisms whereby industry consortiums and the Department of Energy (DOE) have been working with State regulators and other officials in technology deployment decisions within the DOE complex. The historic development of relationships with State regulators is reviewed and the current nature of the relationships examined. The report contains observations from internal DOE reviews as well as recommendations from the General Accounting Office (GAO) and other external organizations. The report discusses reorganization initiatives leading up to a DOE Top-to-Bottom review of the Environmental Management (EM) Program and highlights points of consideration for maintaining effective linkages with State regulators. It notes how the proposed changes will place new demands upon the National Energy Technology Laboratory (NETL) and how NETL can leverage its resources by refocusing existing EM efforts specifically to states that have DOE facilities within their borders (host-states). Finally, the report discusses how SSEB's Permitting Leadership in the United States (PLUS) program can provide the foundation for elements of NETL's technical assistance program that are delivered to regulators and other decision- makers in host-states. As a regional compact commission, SSEB provides important direct linkages to regulators and stakeholders who need

  6. B1细胞与乙型肝炎病毒及丙型肝炎病毒的感染%B1 Cell and Hepatitis B Virus and Hepatitis C Virus Infection

    Institute of Scientific and Technical Information of China (English)

    韩聚强

    2011-01-01

    The pathogenic mechanisms involved in viral hepatitis are not completely understood so far. A number of evidences suggest that the pathology associated with hepatitis B virus( HBV )and hepatitis C virus ( HCV )infections is a result of the immune response in the liver to these viruses. Bl cells are newly found ar important B-cell subgroup, which play a unique and vital innate-like immunizing role in host defense to hepatitis virus. Recent studies have demonstrated that CD5 cell is a distinctive molecular mark. Some results indicate that chronic HBV infection may actually elevate CD5+ Bl cell in peripheral blood,which directly lead tc the chronicity of viral hepatitis B in host immune defense. CD5+ Bl cells are mainly reported to take part m HCV infection by cross-talking between CD81 and CD5.%病毒性肝炎的发病机制迄今为止尚未完全明确,乙型肝炎病毒(HBV)及丙型肝炎病毒(HCV)所致肝炎可能是肝脏细胞免疫防御反应病毒入侵的结果.B1细胞是新近认识的一种B细胞亚群,CD5分子是其特征性分子标志.CD5 +B1细胞是机体防御肝炎病毒入侵的重要天然免疫细胞.CD5 +B1细胞与机体内HBV感染的慢性化密切相关.CD81与CD5间通过分子串话机制直接参与HCV对宿主细胞的感染.

  7. 34 CFR 395.35 - Terms of permit.

    Science.gov (United States)

    2010-07-01

    ..., periodicals, publications, confections, tobacco products, foods, beverages, chances for any lottery authorized... PROPERTY Federal Property Management § 395.35 Terms of permit. Every permit shall describe the location...

  8. 78 FR 27249 - Endangered Species Recovery Permit Applications

    Science.gov (United States)

    2013-05-09

    ...-839213 Applicant: David P. Muth, Martinez, California The applicant requests a permit renewal to take...-804203 Applicant: Stephen J. Meyers, Moreno Valley, California The applicant requests a permit renewal to...

  9. 40 CFR 49.10049 - Permits to operate.

    Science.gov (United States)

    2010-07-01

    ... TRIBAL CLEAN AIR ACT AUTHORITY Implementation Plans for Tribes-Region X Implementation Plan for the Cow Creek Band of Umpqua Indians of Oregon § 49.10049 Permits to operate. Permits to operate are required...

  10. Cumulative Permitted Vernal Pool Losses - Mitigation Sites [ds652

    Data.gov (United States)

    California Department of Resources — This shapefile represents mitigation areas included in the Vernal Pool Clean Water Act Permit Database, developed by AECOM for the Placer Land Trust. The permit...

  11. 75 FR 52965 - Endangered and Threatened Species Permit Applications

    Science.gov (United States)

    2010-08-30

    ... American burying beetle (Nicrophorus americanus) within Oklahoma, Arkansas, and Texas. Permit TE-037155.... Applicant requests a new permit for research and recovery purposes to obtain seeds of Welsh's milkweed... fonticola), San Marcos gambusia (Gambusia georgei), Comal Springs riffle beetle (Heterelmis...

  12. Environmental permitting strategies for the twenty-first century

    Energy Technology Data Exchange (ETDEWEB)

    Munson, B.E.; Wallis, C.M.

    1999-07-01

    Recent trends in economic markets have caused mining companies to look harder at reducing costs for collecting information, performing studies, and conducting other necessary activities to complete environmental permitting. In some cases, it may be in the operator's best interest to delay permitting and related expenditures to the extent possible. In most cases, however, agency mandates and the need to continue operations require that permits be obtained and maintained in the most expedient and economical way possible. This paper explores some basic approaches to environmental permitting which are intended to strategically guide the permitting process through the maze of requirements in a relatively straightforward manner. Through application of common sense and KISS (Keep it simple, stupid) the authors have found that permitting can be conducted in a quicker fashion than most applicants experience. The authors explore and explain some of these basic principles by drawing on their own experiences in the Arizona Aquifer Protection Permit and other environmental permit programs.

  13. Towards tradable permits for filamentous green algae pollution

    CSIR Research Space (South Africa)

    De Lange, Willem J

    2016-09-01

    Full Text Available a reserve price for pollution permits. The subsequent market making process is explained according to five steps including permit design, terms, conditions and transactional protocol, the monitoring system, piloting and implementation. The monetary...

  14. A Framework for Building Efficient Environmental Permitting Processes

    Directory of Open Access Journals (Sweden)

    Nicola Ulibarri

    2017-01-01

    Full Text Available Despite its importance as a tool for protecting air and water quality, and for mitigating impacts to protected species and ecosystems, the environmental permitting process is widely recognized to be inefficient and marked by delays. This article draws on a literature review and interviews with permitting practitioners to identify factors that contribute to delayed permit decisions. The sociopolitical context, projects that are complex or use novel technology, a fragmented and bureaucratic regulatory regime, serial permit applications and reviews, and applicant and permitting agency knowledge and resources each contribute to permitting inefficiency when they foster uncertainty, increase transaction costs, and allow divergent interests to multiply, yet remain unresolved. We then use the interviews to consider the potential of a collaborative dialogue between permitting agencies and applicants to mitigate these challenges, and argue that collaboration is well positioned to lessen permitting inefficiency.

  15. 76 FR 26313 - Endangered and Threatened Species Permit Applications

    Science.gov (United States)

    2011-05-06

    .... Applicant requests a new permit for husbandry and holding of green sea turtles (Chelonia mydas), hawksbill... display for two non-releasable green sea turtles (Chelonia mydas) at the Oklahoma Aquarium. Permit...

  16. 46 CFR 169.211 - Permit to proceed for repair.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Permit to proceed for repair. 169.211 Section 169.211... Inspection and Certification Certificate of Inspection § 169.211 Permit to proceed for repair. (a) The Officer in Charge, Marine Inspection, may issue a permit to proceed to another port for repair, Form...

  17. Markets for tradeable emission and ambient permits : A dynamic approach

    NARCIS (Netherlands)

    Ermoliev, Y; Michalevich, M; Nentjes, A

    This paper discusses trade mechanisms in pollution permit markets. Proofs are given, that sequential, bilateral trade in tradeable emissions permits converges to a market equilibrium with minimal total costs of pollution control. If ambient or deposition permits are traded, the convergence of

  18. 75 FR 45650 - Endangered and Threatened Wildlife and Plants; Permits

    Science.gov (United States)

    2010-08-03

    ... Fish and Wildlife Service Endangered and Threatened Wildlife and Plants; Permits AGENCY: Fish and... endangered species. The Endangered Species Act requires that we invite public comment on this permit... issuance of enhancement of survival permit to conduct certain activities with endangered species...

  19. 50 CFR 20.64 - Foreign export permits.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Foreign export permits. 20.64 Section 20... WILDLIFE AND PLANTS (CONTINUED) MIGRATORY BIRD HUNTING Importations § 20.64 Foreign export permits. No... such birds are accompanied by export permits, tags, or other documentation required by applicable...

  20. 21 CFR 1312.22 - Application for export permit.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Application for export permit. 1312.22 Section... EXPORTATION OF CONTROLLED SUBSTANCES Exportation of Controlled Substances § 1312.22 Application for export permit. (a) An application for a permit to export controlled substances shall be made on DEA Form 161...

  1. 21 CFR 1312.23 - Issuance of export permit.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Issuance of export permit. 1312.23 Section 1312.23... CONTROLLED SUBSTANCES Exportation of Controlled Substances § 1312.23 Issuance of export permit. (a) The... regulation in § 1312.30 of this part be exported only pursuant to the issuance of an export permit. The...

  2. 76 FR 75897 - Endangered and Threatened Species Permit Applications

    Science.gov (United States)

    2011-12-05

    ...-57473A Applicant: Stephen Ramirez, San Marcos, Texas. Applicant requests a new permit for research and..., San Antonio, Texas. Applicant requests an amendment to a current permit for husbandry and holding of..., San Antonio, Texas. Permit TE-58781A Applicant: University of Arizona, Tucson, Arizona....

  3. 40 CFR 270.65 - Research, development, and demonstration permits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Research, development, and... Special Forms of Permits § 270.65 Research, development, and demonstration permits. (a) The Administrator may issue a research, development, and demonstration permit for any hazardous waste treatment facility...

  4. 76 FR 39368 - Migratory Bird Permits; Abatement Regulations

    Science.gov (United States)

    2011-07-06

    ... migratory bird abatement permit. On January 12, 2007, we published a Federal Register notice (72 FR 1556..., we published a Federal Register notice (72 FR 69705-69706) announcing final permit conditions. This... Fish and Wildlife Service 50 CFR Part 21 RIN 1018-AW75 Migratory Bird Permits; Abatement...

  5. 25 CFR 173.13 - Permit not a lease.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Permit not a lease. 173.13 Section 173.13 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER CONCESSIONS, PERMITS AND LEASES ON LANDS WITHDRAWN OR ACQUIRED IN CONNECTION WITH INDIAN IRRIGATION PROJECTS § 173.13 Permit not a lease. Any...

  6. 77 FR 24470 - Marine Mammals; Photography Permit File No. 17032

    Science.gov (United States)

    2012-04-24

    ... National Oceanic and Atmospheric Administration RIN 0648-XA929 Marine Mammals; Photography Permit File No... conduct commercial/educational photography in Alaska. ADDRESSES: The permit and related documents are.../educational photography had been submitted by the above- named applicant. The requested permit has been...

  7. 76 FR 33337 - Endangered Species Recovery Permit Applications

    Science.gov (United States)

    2011-06-08

    ..., Fort Hunter Liggett, California. The applicant requests a permit to take (harass by survey, capture... Fort Hunter Liggett, Monterey County, California, for the purpose of enhancing the species' survival. Permit No. TE-42833A Applicant: Ian Maunsell, San Diego, California. The applicant requests a permit...

  8. 33 CFR 325.6 - Duration of permits.

    Science.gov (United States)

    2010-07-01

    ... Section 325.6 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE PROCESSING OF DEPARTMENT OF THE ARMY PERMITS § 325.6 Duration of permits. (a) General. DA permits... issued for the transport of dredged material for the purpose of disposing of it in ocean waters...

  9. 49 CFR 231.20 - Variation in size permitted.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Variation in size permitted. 231.20 Section 231.20..., DEPARTMENT OF TRANSPORTATION RAILROAD SAFETY APPLIANCE STANDARDS § 231.20 Variation in size permitted. To... total variation of 5 percent below size given is permitted....

  10. 25 CFR 167.11 - Tenure of grazing permits.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Tenure of grazing permits. 167.11 Section 167.11 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO GRAZING REGULATIONS § 167.11 Tenure of grazing permits. (a) All active regular grazing permits shall be for one year and shall...

  11. Cell-cell contact-mediated hepatitis C virus (HCV) transfer, productive infection, and replication and their requirement for HCV receptors.

    Science.gov (United States)

    Liu, Ziqing; He, Johnny J

    2013-08-01

    Hepatitis C virus (HCV) infection is believed to begin with interactions between cell-free HCV and cell receptors that include CD81, scavenger receptor B1 (SR-B1), claudin-1 (CLDN1), and occludin (OCLN). In this study, we have demonstrated that HCV spreading from infected hepatocytes to uninfected hepatocytes leads to the transfer of HCV and the formation of infection foci and is cell density dependent. This cell-cell contact-mediated (CCCM) HCV transfer occurs readily and requires all these known HCV receptors and an intact actin cytoskeleton. With a fluorescently labeled replication-competent HCV system, the CCCM transfer process was further dissected by live-cell imaging into four steps: donor cell-target cell contact, formation of viral puncta-target cell conjugation, transfer of viral puncta, and posttransfer. Importantly, the CCCM HCV transfer leads to productive infection of target cells. Taken together, these results show that CCCM HCV transfer constitutes an important and effective route for HCV infection and dissemination. These findings will aid in the development of new and novel strategies for preventing and treating HCV infection.

  12. 76 FR 36917 - Clean Air Act Operating Permit Program; Petition for Objection to State Operating Permit for...

    Science.gov (United States)

    2011-06-23

    ... AGENCY Clean Air Act Operating Permit Program; Petition for Objection to State Operating Permit for TransAlta Centralia Generation, LLC--Coal- Fired Power Plant AGENCY: Environmental Protection Agency (EPA... to a citizen petition asking EPA to object to an operating permit issued by the Southwest Clean...

  13. 10 CFR 51.50 - Environmental report-construction permit, early site permit, or combined license stage.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Environmental report-construction permit, early site... Environmental Policy Act-Regulations Implementing Section 102(2) Environmental Reports-Production and Utilization Facilities § 51.50 Environmental report—construction permit, early site permit, or...

  14. 75 FR 81139 - Migratory Bird Permits; States Delegated Falconry Permitting Authority; Technical Corrections to...

    Science.gov (United States)

    2010-12-27

    ... number of small entities. This rule delegates authority to States that have requested it, and those... Falconry Permitting Authority; Technical Corrections to the Regulations AGENCY: Fish and Wildlife Service..., South Dakota, and Washington have requested that we, the U.S. Fish and Wildlife Service, delegate...

  15. 14 CFR 211.20 - Initial foreign air carrier permit or transfer of a permit.

    Science.gov (United States)

    2010-01-01

    ... TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS APPLICATIONS FOR PERMITS TO FOREIGN AIR CARRIERS..., etc., from the beginning of operations to the present. Also, if the applicant is a new airline (i.e., an airline that began direct air services within the past 12 months), briefly summarize the business...

  16. 30 CFR 937.773 - Requirements for permits and permit processing.

    Science.gov (United States)

    2010-07-01

    ... on State lands (ORS 273.005-273.815); Solid Waste Disposal Permits, Hazardous Waste Transportation.... 937.773 Section 937.773 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR PROGRAMS FOR THE CONDUCT OF SURFACE MINING OPERATIONS WITHIN EACH STATE OREGON...

  17. Permit Allocation in Emissions Trading using the Boltzmann Distribution

    CERN Document Server

    Park, Ji-Won; Isard, Walter

    2011-01-01

    In emissions trading, the initial permit allocation is an intractable issue because it needs to be essentially fair to the participating countries. There are many ways to distribute a given total amount of emissions permits among countries, but the existing distribution methods such as auctioning and grandfathering have been debated. Here we describe a new model for permit allocation in emissions trading using the Boltzmann distribution. The Boltzmann distribution is introduced to permit allocation by combining it with concepts in emissions trading. A price determination mechanism for emission permits is then developed in relation to the {\\beta} value in the Boltzmann distribution. Finally, it is demonstrated how emissions permits can be practically allocated among participating countries in empirical results. The new allocation model using the Boltzmann distribution describes a most probable, natural, and unbiased distribution of emissions permits among multiple countries. Based on its simplicity and versati...

  18. Central line infections - hospitals

    Science.gov (United States)

    ... infection; Central venous catheter - infection; CVC - infection; Central venous device - infection; Infection control - central line infection; Nosocomial infection - central line infection; Hospital acquired ...

  19. Hookworm infection

    Science.gov (United States)

    Hookworm disease; Ground itch; Ancylostoma duodenale infection; Necator americanus infection; Parasitic infection - hookworm ... The infection is caused by infestation with any of the following ... Ancylostoma duodenale Ancylostoma ceylanicum Ancylostoma ...

  20. Kidney Infection

    Science.gov (United States)

    ... X-ray called a voiding cystourethrogram. Antibiotics for kidney infections Antibiotics are the first line of treatment ... the infection is completely eliminated. Hospitalization for severe kidney infections For a severe kidney infection, your doctor ...

  1. Watershed-based point sources permitting strategy and dynamic permit-trading analysis.

    Science.gov (United States)

    Ning, Shu-Kuang; Chang, Ni-Bin

    2007-09-01

    Permit-trading policy in a total maximum daily load (TMDL) program may provide an additional avenue to produce environmental benefit, which closely approximates what would be achieved through a command and control approach, with relatively lower costs. One of the important considerations that might affect the effective trading mechanism is to determine the dynamic transaction prices and trading ratios in response to seasonal changes of assimilative capacity in the river. Advanced studies associated with multi-temporal spatially varied trading ratios among point sources to manage water pollution hold considerable potential for industries and policy makers alike. This paper aims to present an integrated simulation and optimization analysis for generating spatially varied trading ratios and evaluating seasonal transaction prices accordingly. It is designed to configure a permit-trading structure basin-wide and provide decision makers with a wealth of cost-effective, technology-oriented, risk-informed, and community-based management strategies. The case study, seamlessly integrating a QUAL2E simulation model with an optimal waste load allocation (WLA) scheme in a designated TMDL study area, helps understand the complexity of varying environmental resources values over space and time. The pollutants of concern in this region, which are eligible for trading, mainly include both biochemical oxygen demand (BOD) and ammonia-nitrogen (NH3-N). The problem solution, as a consequence, suggests an array of waste load reduction targets in a well-defined WLA scheme and exhibits a dynamic permit-trading framework among different sub-watersheds in the study area. Research findings gained in this paper may extend to any transferable dynamic-discharge permit (TDDP) program worldwide.

  2. Geothermal policy development program: expediting the local geothermal permitting process

    Energy Technology Data Exchange (ETDEWEB)

    1981-07-01

    For a number of years, concerns have been raised about the length of time and the complexity involved in obtaining required permits in order to develop the geothermal resource at the Geysers. Perhaps the most important factor is jurisdiction. At the Geysers, all three levels of government - local, state, and federal - exercise significant authority over various aspects of geothermal development. In addition, several agencies within each governmental level play an active role in the permitting process. The present study is concerned primarily with the local permitting process, and the ways in which this process could be expedited. This report begins by looking at the local role in the overall permitting process, and then reviews the findings and conclusions that have been reached in other studies of the problem. This is followed by a case study evaluation of recent permitting experience in the four Geysers-Calistoga KGRA counties, and the report concludes by outlining several approaches to expediting the local permitting process.

  3. Case history review--demilitarization combustion permits.

    Science.gov (United States)

    Gaborek, B J

    2000-02-01

    In May 1993, Administrative Browner of the U.S. Environmental Protection Agency (USEPA) announced that an indirect exposure health risk assessment was required for all hazardous waste combustion facilities seeking a Resource Conservation and Recovery Act permit. These types of risk assessments evaluate the health and environmental effects from inhalation of emissions (direct exposure) and from contact with environmental media and consumption of food products impacted by the emissions (indirect exposure). Completion of an indirect exposure risk assessment is often complicated by the various methodologies available for generating results and by the requirements of the regulating community. To minimize this complexity and to maximize consistency between risk assessments, the USEPA developed a number of detailed guidance documents. Site-specific conditions and toxicological data gaps, however, continue to present challenges not addressed by these guidance documents. This paper presents some of the specific challenges encountered by the U.S. Army Center for Health Promotion and Preventive Medicine when performing indirect exposure health risk assessments for several demilitarization combustion facilities.

  4. Guide to Permitting Hydrogen Motor Fuel Dispensing Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Rivkin, Carl [National Renewable Energy Lab. (NREL), Golden, CO (United States); Buttner, William [National Renewable Energy Lab. (NREL), Golden, CO (United States); Burgess, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-03-28

    The purpose of this guide is to assist project developers, permitting officials, code enforcement officials, and other parties involved in developing permit applications and approving the implementation of hydrogen motor fuel dispensing facilities. The guide facilitates the identification of the elements to be addressed in the permitting of a project as it progresses through the approval process; the specific requirements associated with those elements; and the applicable (or potentially applicable) codes and standards by which to determine whether the specific requirements have been met. The guide attempts to identify all applicable codes and standards relevant to the permitting requirements.

  5. 78 FR 12776 - Endangered and Threatened Species Permit Applications

    Science.gov (United States)

    2013-02-25

    ... (Eretmochelys imbricata) within Sea Life Aquarium, Grapevine, Texas. Permit TE-92366A Applicant: Kimley-Horn and... borealis) within Alabama, Arkansas, Florida, Georgia, Louisiana, Mississippi, Missouri, North...

  6. Industrial Fuel Gas Demonstration Plant Program: environmental permit compliance plan

    Energy Technology Data Exchange (ETDEWEB)

    Bodamer, Jr., James W.; Bocchino, Robert M.

    1979-11-01

    This Environmental Permit Compliance Plan is intended to assist the Memphis Light, Gas and Water Division in acquiring the necessary environmental permits for their proposed Industrial Fuel Gas Demonstration Plant in a time frame consistent with the construction schedule. Permits included are those required for installation and/or operation of gaseous, liquid and solid waste sources and disposal areas. Only those permits presently established by final regulations are described. The compliance plan describes procedures for obtaining each permit from identified federal, state and local agencies. The information needed for the permit application is presented, and the stepwise procedure to follow when filing the permit application is described. Information given in this plan was obtained by reviewing applicable laws and regulations and from telephone conversations with agency personnel on the federal, state and local levels. This Plan also presents a recommended schedule for beginning the work necessary to obtain the required environmental permits in order to begin dredging operations in October, 1980 and construction of the plant in September, 1981. Activity for several key permits should begin as soon as possible.

  7. 76 FR 57757 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2011-09-16

    ...-47878A The applicant requests a permit to import biological specimens of African dwarf crocodiles (Osteolaemus tetraspis tetraspis) and slender snouted crocodiles (Crocodylus cataphractus) collected from...

  8. 76 FR 14424 - Endangered Species Recovery Permit Applications

    Science.gov (United States)

    2011-03-16

    ... applicant requests a permit to take (survey by pursuit) the Quino checkerspot butterfly... pursuit) the Quino checkerspot butterfly (Euphydryasedithaquino) in conjunction with surveys throughout...

  9. 76 FR 63322 - Endangered and Threatened Species Permit Applications

    Science.gov (United States)

    2011-10-12

    ...), hawksbill (Eretmochelys imbricata), green (Chelonia mydas), and loggerhead (Caretta caretta) sea turtles.... Applicant requests a new permit for husbandry and holding of green (Chelonia mydas) sea turtles within...

  10. Identification of a millisecond isomeric state in 129Cd81via the detection of internal conversion and Compton electrons

    Energy Technology Data Exchange (ETDEWEB)

    Taprogge, J.; Jungclaus, A.; Grawe, H.; Nishimura, S.; Xu, Z. Y.; Doornenbal, P.; Lorusso, G.; Nacher, E.; Simpson, G. S.; Soderstrom, P. A.; Sumikama, T.; Kondev, F. G.

    2014-11-10

    The decay of an isomeric state in the neutron-rich nucleus 129Cd has been observed via the detection of internal conversion and Compton electrons providing first experimental information on excited states in this nucleus. The isomer was populated in the projectile fission of a 238U beam at the Radioactive Isotope Beam Factory at RIKEN. From the measured yields of γ-rays and internal conversion electrons, a multipolarity of E 3 was tentatively assigned to the isomeric transition. A half-life of T1/2=3.6(2) msT1/2=3.6(2) ms was determined for the new state which was assigned a spin of (21/2+)(21/2+), based on a comparison to shell model calculations performed using state-of-the-art realistic effective interactions.

  11. Cooperative Emissions Trading Game: International Permit Market Dominated by Buyers.

    Science.gov (United States)

    Honjo, Keita

    2015-01-01

    Rapid reduction of anthropogenic greenhouse gas emissions is required to mitigate disastrous impacts of climate change. The Kyoto Protocol introduced international emissions trading (IET) to accelerate the reduction of carbon dioxide (CO2) emissions. The IET controls CO2 emissions through the allocation of marketable emission permits to sovereign countries. The costs for acquiring additional permits provide buyers with an incentive to reduce their CO2 emissions. However, permit price has declined to a low level during the first commitment period (CP1). The downward trend in permit price is attributed to deficiencies of the Kyoto Protocol: weak compliance enforcement, the generous allocation of permits to transition economies (hot air), and the withdrawal of the US. These deficiencies created a buyer's market dominated by price-making buyers. In this paper, I develop a coalitional game of the IET, and demonstrate that permit buyers have dominant bargaining power. In my model, called cooperative emissions trading (CET) game, a buyer purchases permits from sellers only if the buyer forms a coalition with the sellers. Permit price is determined by bargaining among the coalition members. I evaluated the demand-side and supply-side bargaining power (DBP and SBP) using Shapley value, and obtained the following results: (1) Permit price is given by the product of the buyer's willingness-to-pay and the SBP (= 1 - DBP). (2) The DBP is greater than or equal to the SBP. These results indicate that buyers can suppress permit price to low levels through bargaining. The deficiencies of the Kyoto Protocol enhance the DBP, and contribute to the demand-side dominance in the international permit market.

  12. 48 CFR 52.247-2 - Permits, Authorities, or Franchises.

    Science.gov (United States)

    2010-10-01

    ... Franchises. 52.247-2 Section 52.247-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....247-2 Permits, Authorities, or Franchises. As prescribed in 47.207-1(a), insert the following clause: Permits, Authorities, or Franchises (JAN 1997) (a) The offeror does □, does not □, hold authorization...

  13. 50 CFR 22.24 - Permits for falconry purposes.

    Science.gov (United States)

    2010-10-01

    ... government employee who has trapped a golden eagle under a Federal depredation permit or under a depredation... location. A golden eagle may only be taken from a livestock or wildlife depredation area declared by USDA Wildlife Services and permitted under § 22.23, or from a livestock depredation area authorized in...

  14. 75 FR 27814 - Receipt of Applications for Permit

    Science.gov (United States)

    2010-05-18

    ... in the Zoological Society of San Diego's original permit. Applicant: George Carden Circus... education. The permit numbers and animals are: 070854, Bimbo Jr.; 079868, Vickie; 079870, Jenny; 079871... FR 9251). We made an error and neglected to report one species from which specimens would be...

  15. Waste Feed Delivery Environmental Permits and Approvals Plan

    Energy Technology Data Exchange (ETDEWEB)

    TOLLEFSON, K.S.

    2000-01-18

    This plan describes the environmental permits approvals, and other requirements that may affect establishment of a waste feed delivery system for the Hanford Site's River Protection Project. This plan identifies and screens environmental standards for potential applicability, outlines alternatives for satisfying applicable standards, and describes preferred permitting and approval approaches.

  16. 50 CFR 300.182 - HMS international trade permit.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false HMS international trade permit. 300.182... FISHERIES REGULATIONS International Trade Documentation and Tracking Programs for Highly Migratory Species § 300.182 HMS international trade permit. (a) General. An importer, entering for consumption fish or...

  17. 46 CFR 30.10-49 - Permit-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Permit-TB/ALL. 30.10-49 Section 30.10-49 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-49 Permit—TB/ALL. The term permit refers to endorsement on the certificate of inspection, authorizing the presence...

  18. 75 FR 59711 - Audit Program for Texas Flexible Permit Holders

    Science.gov (United States)

    2010-09-28

    ... waiver of the gravity component of any penalties resulting from noncompliance uncovered by the Audit... on the Audit Program for Texas flexible permit holders, please contact Mr. John Jones, Air...). EPA is proposing the Audit Program as a mechanism for Texas Flexible Permit holders to transition...

  19. 40 CFR 264.344 - Hazardous waste incinerator permits.

    Science.gov (United States)

    2010-07-01

    ... WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Incinerators § 264.344 Hazardous waste incinerator permits. (a) The owner or operator of a... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Hazardous waste incinerator permits...

  20. 76 FR 33334 - Endangered and Threatened Wildlife and Plants; Permits

    Science.gov (United States)

    2011-06-08

    ... Fish and Wildlife Service Endangered and Threatened Wildlife and Plants; Permits AGENCY: Fish and... receipt of applications to conduct certain activities pertaining to enhancement of survival of endangered species. The Endangered Species Act requires that we invite public comment on these permit...

  1. 75 FR 27361 - Endangered and Threatened Wildlife and Plants; Permits

    Science.gov (United States)

    2010-05-14

    ... Fish and Wildlife Service Endangered and Threatened Wildlife and Plants; Permits AGENCY: Fish and... receipt of applications to conduct certain activities pertaining to enhancement of survival of endangered species. The Endangered Species Act requires that we invite public comment on these permit...

  2. 76 FR 8374 - Endangered and Threatened Wildlife and Plants; Permits

    Science.gov (United States)

    2011-02-14

    ... Fish and Wildlife Service Endangered and Threatened Wildlife and Plants; Permits AGENCY: Fish and... receipt of applications to conduct certain activities pertaining to enhancement of survival of endangered species. The Endangered Species Act requires that we invite public comment on these permit...

  3. 75 FR 52012 - Endangered and Threatened Wildlife and Plants; Permits

    Science.gov (United States)

    2010-08-24

    ... Fish and Wildlife Service Endangered and Threatened Wildlife and Plants; Permits AGENCY: Fish and... receipt of applications to conduct certain activities pertaining to enhancement of survival of endangered species. The Endangered Species Act requires that we invite public comment on these permit...

  4. 76 FR 18576 - Endangered and Threatened Wildlife and Plants; Permits

    Science.gov (United States)

    2011-04-04

    ... Fish and Wildlife Service Endangered and Threatened Wildlife and Plants; Permits AGENCY: Fish and... receipt of applications to conduct certain activities pertaining to enhancement of survival of endangered species. The Endangered Species Act requires that we invite public comment on these permit...

  5. 76 FR 10063 - Endangered and Threatened Wildlife and Plants; Permits

    Science.gov (United States)

    2011-02-23

    ... Fish and Wildlife Service Endangered and Threatened Wildlife and Plants; Permits AGENCY: Fish and... receipt of applications to conduct certain activities pertaining to enhancement of survival of endangered species. The Endangered Species Act requires that we invite public comment on these permit...

  6. 75 FR 5101 - Endangered and Threatened Wildlife and Plants; Permits

    Science.gov (United States)

    2010-02-01

    ... Fish and Wildlife Service Endangered and Threatened Wildlife and Plants; Permits AGENCY: Fish and... receipt of applications to conduct certain activities pertaining to enhancement of survival of endangered species. The Endangered Species Act requires that we invite public comment on these permit...

  7. 50 CFR 15.22 - Permits for scientific research.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false Permits for scientific research. 15.22... for scientific research. (a) Application requirements for permits for scientific research. Each... description of the scientific research to be conducted on the exotic bird requested, including: (i) Formal...

  8. 78 FR 20352 - Endangered and Threatened Species Permit Applications

    Science.gov (United States)

    2013-04-04

    ... Applicant: Bat Conservation International, Austin, Texas. Applicant requests a new permit for research and... (Dermochelys coriacea) Hawksbill (Eretmochelys imbricata) Permit TE-98704A Applicant: Dogs for Conservation... Houston toads (Bufo houstonensis) from the Houston Zoo for work with training dogs how to detect...

  9. 75 FR 427 - Receipt of Applications for Permit

    Science.gov (United States)

    2010-01-05

    ... purpose of enhancement of the survival of the species. Applicant: Wildlife Conservation Society, Bronx Zoo... ADDRESSES. Applicant: Chelonian Conservation Center, Ojai, CA, PRT-217124 The applicant requests a permit to... period. Applicant: Metro Richmond Zoo, Moseley, VA, PRT-228022 The applicant requests a permit to...

  10. 46 CFR 78.40-10 - No smoking permitted.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 3 2010-10-01 2010-10-01 false No smoking permitted. 78.40-10 Section 78.40-10 Shipping... § 78.40-10 No smoking permitted. (a) The master shall have appropriate “No Smoking” signs posted and shall take all necessary precautions to prevent smoking or carrying of lighted or smoldering...

  11. 76 FR 34095 - Endangered Species Receipt of Applications for Permit

    Science.gov (United States)

    2011-06-10

    ... permit to import biological samples from ring-tailed lemur (Lemur catta), collected in the wild in... the applicant over a 5-year period. Applicant: Duke Lemur Center, Duke University, Durham, NC; PRT-43685A The applicant requests a permit to import biological samples from mouse lemur species (Microcebus...

  12. 25 CFR 173.20 - Revocation of permits.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Revocation of permits. 173.20 Section 173.20 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER CONCESSIONS, PERMITS AND LEASES ON LANDS WITHDRAWN OR ACQUIRED IN CONNECTION WITH INDIAN IRRIGATION PROJECTS § 173.20 Revocation of...

  13. 36 CFR 20.4 - Revocation of permits; appeal.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Revocation of permits; appeal. 20.4 Section 20.4 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR ISLE ROYALE NATIONAL PARK; COMMERCIAL FISHING § 20.4 Revocation of permits; appeal. The...

  14. 76 FR 67650 - Migratory Bird Permits; Abatement Regulations

    Science.gov (United States)

    2011-11-02

    ... for a specific permit authorizing the use of raptors in abatement activities (76 FR 39368). The... the advance notice of proposed rulemaking, please refer to that document at 76 FR 39368 (July 6, 2011... Fish and Wildlife Service 50 CFR Part 21 RIN 1018-AW75 Migratory Bird Permits; Abatement...

  15. 25 CFR 163.26 - Forest product harvesting permits.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Forest product harvesting permits. 163.26 Section 163.26... Forest Management and Operations § 163.26 Forest product harvesting permits. (a) Except as provided in §§ 163.13 and 163.27 of this part, removal of forest products that are not under formal...

  16. 76 FR 7577 - Endangered and Threatened Species Permit Applications

    Science.gov (United States)

    2011-02-10

    ...--Sonora Desert Museum, Tucson, Arizona. Applicant requests an amendment to a current permit for research... topminnow (Poeciliopsis occidentalis sonoriensis) at the museum. Permit TE-31412A Applicant: John Kuba... recovery purposes to conduct presence/absence surveys for the following species: Texas blind...

  17. 19 CFR 12.104c - Importations permitted.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Importations permitted. 12.104c Section 12.104c Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY SPECIAL CLASSES OF MERCHANDISE Cultural Property § 12.104c Importations permitted....

  18. 76 FR 27307 - Marine Mammals; Photography Permit Application No. 16360

    Science.gov (United States)

    2011-05-11

    ... National Oceanic and Atmospheric Administration RIN 0648-XA426 Marine Mammals; Photography Permit..., Auckland, New Zealand has applied in due form for a permit to conduct commercial/educational photography of... for photography for educational or commercial purposes involving non-endangered and...

  19. 76 FR 40338 - Marine Mammals; Photography Permit No. 16360

    Science.gov (United States)

    2011-07-08

    ... National Oceanic and Atmospheric Administration Marine Mammals; Photography Permit No. 16360 AGENCY..., Auckland, New Zealand to conduct commercial/educational photography of cetaceans off Hawaii. ADDRESSES: The... request for a permit to conduct commercial/educational photography on 12 cetacean species had...

  20. 77 FR 2037 - Marine Mammals; Photography Permit File No. 17032

    Science.gov (United States)

    2012-01-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA929 Marine Mammals; Photography Permit File No... for a permit to conduct commercial or educational photography on killer (Orcinus orca) and...

  1. 77 FR 49483 - Actions on Special Permit Applications

    Science.gov (United States)

    2012-08-16

    ... liters (11888 USWG) max. 11458-M Costco Wholesale, 49 CFR 172.203(a) and To modify the special permit.... 11836-M Hydrite Chemical Co., 49 CFR 173.24; 173.203.. To modify the special permit Brookfield, WI. by... 173.159 To authorize the Group, Inc., Milwaukee, transportation in commerce WI. of certain...

  2. 9 CFR 82.23 - Issuance of permits.

    Science.gov (United States)

    2010-01-01

    ... poultry, vehicles, cages, coops, containers, troughs, or other equipment or material if the interstate... INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS EXOTIC NEWCASTLE DIS- EASE (END) AND CHLAMYDIOSIS Chlamydiosis in Poultry § 82.23 Issuance of permits. (a) Application for the permit...

  3. 77 FR 31044 - Permits Issued Under the Antarctic Conservation Act

    Science.gov (United States)

    2012-05-24

    ... No: 2012-12616] NATIONAL SCIENCE FOUNDATION Permits Issued Under the Antarctic Conservation Act AGENCY: National Science Foundation. ACTION: Notice of permits issued under the Antarctic Conservation of 1978, Public Law 95-541. SUMMARY: The National Science Foundation (NSF) is required to publish...

  4. 78 FR 37840 - Endangered Species Recovery Permit Applications

    Science.gov (United States)

    2013-06-24

    ... applicant requests a permit to take (survey by pursuit) the Quino checkerspot butterfly (Euphydryas editha quino) in conjunction with surveys throughout the range of the species in California for the purpose of... applicant requests a permit to take (survey by pursuit) the Quino checkerspot butterfly (Euphydryas editha...

  5. 76 FR 50751 - Endangered Species Recovery Permit Applications

    Science.gov (United States)

    2011-08-16

    ..., San Diego, California The applicant requests a permit to take (survey by pursuit) the Quino checkerspot butterfly (Euphydryas editha quino) and take (capture, collect, and kill) the Conservancy fairy... Gadsby, Encinitas, California The applicant requests a permit to take (survey by pursuit) the Quino...

  6. 77 FR 54604 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2012-09-05

    ... applicant requests a permit to export sport hunted trophies of one male addax (Addax nasomaculatus), one.... Applicant: John Fry, Carson City, NV; PRT-82592A The applicant requests a permit to import a sport-hunted trophy of one male bontebok (Damaliscus pygargus pygargus) culled from a captive herd maintained...

  7. 75 FR 38117 - Receipt of Applications for Permit

    Science.gov (United States)

    2010-07-01

    ...-hunted trophy of one female scimitar-horned oryx (Oryx dammah) taken in the Republic of South Africa, for...; PRT-10400A The applicant requests a permit to import the sport-hunted trophy of one male scimitar... permit to import a sport-hunted trophy of one male bontebok (Damaliscus pygargus pygargus) culled from...

  8. 29 CFR 2.12 - Audiovisual coverage permitted.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Audiovisual coverage permitted. 2.12 Section 2.12 Labor Office of the Secretary of Labor GENERAL REGULATIONS Audiovisual Coverage of Administrative Hearings § 2.12 Audiovisual coverage permitted. The following are the types of hearings where the...

  9. Permitted Suicide: Model Roles for Mental Health Counseling.

    Science.gov (United States)

    Cohen, Elliot D.

    2001-01-01

    In mental health practice, no explicit provisions have been made for existing law and codes of ethics to protect freedom and confidences of clients who rationally desire to end their lives. Makes a case for permitting suicide by providing an analysis of permitted suicide, the legal background for applying this concept, and ten model rules for…

  10. Shigella Infections

    Science.gov (United States)

    ... Old Feeding Your 1- to 2-Year-Old Shigella Infections KidsHealth > For Parents > Shigella Infections Print A ... the Doctor en español Infecciones por Shigella About Shigella Shigella are bacteria that can infect the digestive ...

  11. Spinal Infections

    Science.gov (United States)

    ... infections may occur following surgery or spontaneously in patients with certain risk factors. Risk factors for spinal infections include poor nutrition, immune suppression, human immunodeficiency virus (HIV) infection, cancer, diabetes and obesity. Surgical risk factors ...

  12. Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

    OpenAIRE

    Tseng, Ching Wen; Sanchez-Martinez, Marisel; Arruda, Andrea; Liu, George Y.

    2011-01-01

    MRSA is a worldwide threat to public health, and MRSA skin and soft-tissue infections now account for more than half of all soft-tissue infections in the United States. Among soft-tissue infections, myositis, pyomyositis, and necrotizing fasciitis have been increasingly reported in association with MRSA arising from the community. To understand the interplay between MRSA and host immunity leading to more severe infection, the availability of animal models is critical, permitting the study o...

  13. Qualitative identification of permitted and non-permitted color additives in cosmetics.

    Science.gov (United States)

    Miranda-Bermudez, Enio; Harp, Bhakti Petigara; Barrows, Julie N

    2014-01-01

    Color additives are dyes, pigments, or other substances that can impart color when added or applied to foods, drugs, cosmetics, medical devices, or the human body. These substances must be pre-approved by the U.S. Food and Drug Administration (FDA) and listed in the Code of Federal Regulations before they may be used in FDA-regulated products. Both domestic and imported cosmetic products sold in interstate commerce fall under FDA jurisdiction, and FDA's district laboratories use a combination of analytical methods for identifying or confirming the presence of potentially violative color additives. We have developed a qualitative method for identifying 29 water- and methanol-soluble color additives in various types of cosmetic products. The color additives are extracted with combinations of methylene chloride, methanol, acetic acid, and water and are identified by LC with photodiode array detection. Estimated LOD values ranged from 0.1 to 1.5 mg/L. A survey of lip products, nail polishes, eye products, blushes, body glitter, face paints, bath products, creams, and toothpastes identified permitted and non-permitted color additives. Our new LC method is intended to supplement the visible spectrophotometry and TLC methods currently used by FDA's district laboratories and will help optimize the use of time, labor, and solvents.

  14. Infective Endocarditis

    Science.gov (United States)

    ... Artery Disease Venous Thromboembolism Aortic Aneurysm More Infective Endocarditis Updated:Oct 10,2016 View an illustration of endocarditis Infective endocarditis (IE), also called bacterial endocarditis (BE), ...

  15. 77 FR 13601 - Notice of Proposed NPDES General Permit; Proposed NPDES General Permit for New and Existing...

    Science.gov (United States)

    2012-03-07

    ... discharging to the Outer Continental Shelf offshore of Louisiana and Texas. The discharge of produced water to... study to obtain more representative data to evaluate impacts to water quality. Marine Protection... territorial seas of Louisiana and Texas is also authorized by this permit. This draft permit proposes...

  16. 75 FR 75463 - Clean Air Act Operating Permit Program; Petition To Object to Title V Permit for Luke Paper...

    Science.gov (United States)

    2010-12-03

    ... From the Federal Register Online via the Government Publishing Office ENVIROMENTAL PROTECTION AGENCY Clean Air Act Operating Permit Program; Petition To Object to Title V Permit for Luke Paper... issues during the comment period or that the grounds for objection or other issue arose after the comment...

  17. 10 CFR 51.105 - Public hearings in proceedings for issuance of construction permits or early site permits...

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Public hearings in proceedings for issuance of construction permits or early site permits; limited work authorizations. 51.105 Section 51.105 Energy NUCLEAR... concerning the benefits assessment (e.g., need for power) or alternative energy sources if those issues...

  18. Political and Economic Scope for Permit Markets in Europe

    DEFF Research Database (Denmark)

    Svendsen, Gert Tinggaard

    1999-01-01

    (organized polluters) due to the possibility of a free, initial distribution (grand-fathering). As such, a mix of green taxes (in relation to non-organized interests) and grandfathered permit markets (in relation to organized interests) should be considered in the search for cost-effective and politically...... of permit markets in the US. Therefore, the policy recommendation for e.g. CO2 reduction in Europe is to apply taxation in relation to large and non-organized groups only, such as households and the transportation sector. A permit market, on the other hand, is politically more attrac-tive to the industry...

  19. Political and Economic Scope for Permit Markets in Europe

    DEFF Research Database (Denmark)

    Svendsen, Gert Tinggaard

    1999-01-01

    (organized polluters) due to the possibility of a free, initial distribution (grand-fathering). As such, a mix of green taxes (in relation to non-organized interests) and grandfathered permit markets (in relation to organized interests) should be considered in the search for cost-effective and politically...... of permit markets in the US. Therefore, the policy recommendation for e.g. CO2 reduction in Europe is to apply taxation in relation to large and non-organized groups only, such as households and the transportation sector. A permit market, on the other hand, is politically more attrac-tive to the industry...

  20. Storm Water General Permit 3 for Rock and Asphalt

    Data.gov (United States)

    Iowa State University GIS Support and Research Facility — General permit #3 for storm water discharges associated with industrial activity for Asphalt Plants, Concrete Batch Plants, Rock Crushing Plants and Construction...

  1. Storm Water General Permit 1 for Industrial Facilities

    Data.gov (United States)

    Iowa State University GIS Support and Research Facility — General permit #1 for storm water discharges associated with industrial facilities in Iowa for the National Pollutant Discharge Elimination System (NPDES) program.

  2. 46 CFR 115.204 - Permit to carry excursion party.

    Science.gov (United States)

    2010-10-01

    ... issued an excursion permit will normally be required to meet the minimum stability, survival craft, life jacket, fire safety, and manning standards applicable to a vessel in the service for which the excursion...

  3. 50 CFR 21.30 - Raptor propagation permits.

    Science.gov (United States)

    2010-10-01

    ... entirely enclosed with wood, wire netting, or other suitable material which provides a safe, health... sport of falconry only if such use is designated in both the propagation permit and the permittee's...

  4. 75 FR 82409 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2010-12-30

    ..., reproductive physiology, genetics, nutrition, and animal health and is a continuation of activities currently.... Applicant: Reggie Pratt, Minot, ME; PRT-30840A. The applicant requests a permit to import a sport-hunted...

  5. 75 FR 34766 - Receipt of Applications for Permit

    Science.gov (United States)

    2010-06-18

    ... Agriculture/Animal and Plant Health Inspection Service/Wildlife Service/ National Wildlife Research Center... following applicants each request a permit to import the sport- hunted trophy of one male bontebok...

  6. 75 FR 14627 - Receipt of Applications for Permit

    Science.gov (United States)

    2010-03-26

    ... permit to import a female cheetah (Acrinonyx jubatus) from DeWildt Cheetah Breeding Centre, South Africa where the individual cheetah was captive bred for the purpose of enhancement of the survival of the...

  7. 2016: Special Use Permits : Rocky Mountain Arsenal NWR Complex

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This reference is a collection of Special Use Permits originating from the Rocky Mountain Arsenal NWR Complex. The Complex consists of Rocky Mountain Arsenal NWR,...

  8. 78 FR 57650 - Endangered Species Recovery Permit Applications

    Science.gov (United States)

    2013-09-19

    ..., Arizona, New Mexico, Texas, Utah, and Colorado for the purpose of enhancing the species' survival. Permit... San Francisco garter snake (Thamnophis sirtalis tetrataenia) and take (harass by survey, capture...

  9. 77 FR 15383 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2012-03-15

    .... The proposed research will cover all aspects of behavior, reproductive physiology, genetics, nutrition...Nicol, Chandler, AR; PRT-66555A The applicant requests a permit to import a sport-hunted trophy of...

  10. 77 FR 7599 - Receipt of Applications for Endangered Species Permits

    Science.gov (United States)

    2012-02-13

    ... personal identifying information--may be made publicly available at any time. While you can ask us in your... Applicant: Daniel Judy, Mount Dora, Florida Applicant requests amendment of permit to allow for the take...

  11. 76 FR 46837 - Endangered and Threatened Species Permit Applications

    Science.gov (United States)

    2011-08-03

    ... your personal identifying information--may be made publicly available at any time. While you can ask us... Cave mold beetle (Batrisodes texanus) . Permit TE-170625 Applicant: Daniel Howard, Sioux Falls,...

  12. 2012: Special Use Permits : Rocky Mountain Arsenal NWR Complex

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This reference is a collection of Special Use Permits originating from the Rocky Mountain Arsenal NWR Complex. The Complex consists of Rocky Mountain Arsenal NWR,...

  13. 75 FR 4136 - Pipeline Safety: Requests for Special Permit

    Science.gov (United States)

    2010-01-26

    ... construction hydrostatic testing of the pipeline. These original construction hydrostatic tests were conducted more than thirty years ago. The application is for a special permit to waive the requirement to...

  14. Market power in auction and efficiency in emission permits allocation.

    Science.gov (United States)

    Jiang, Min Xing; Yang, Dong Xiao; Chen, Zi Yue; Nie, Pu Yan

    2016-12-01

    This paper analyzes how to achieve the cost-effectiveness by initial allocation of CO2 emission permits when a single dominant firm in production market has market power in auction, and compare two prevalent allocation patterns, mixed allocation and single auction. We show how the firm with market power may manipulate the auction price, thereby this leads to fail to achieve cost-effective solution by auction unless the total permits for allocation equal to the effective emissions cap. Provided that the market power firm receives strictly positive free permits, the effective emissions cap of mixed allocation is larger than that of single auction. The production market share of dominant firm is increasing with the free permits it holds. Finally, we examine the compliance costs and welfare of mixed allocation and single auction, the result show that the former is preferred to the later when policy makers consider economic welfare without welfare cost due to CO2 emissions.

  15. 77 FR 29453 - Applications for Modification of Special Permit

    Science.gov (United States)

    2012-05-17

    .... permit to authorize the containment cylinder or salvage cylinder without the internal piston. 11914-M... classified as other than Class 1 dependent on the characteristics of the AE. BILLING CODE 4909-60-M...

  16. EPA Office of Water (OW): Pollutant Discharge Permit Status

    Data.gov (United States)

    U.S. Environmental Protection Agency — U.S. States (Generalized) represents the 50 states and the District of Columbia of the United States joined with data from the NPDES Permit Backlog Report for the...

  17. Cameron Trading Post; Proposed NPDES Permit NN0021610

    Science.gov (United States)

    EPA is proposing to issue NPDES permit (No. NN0021610) to Cameron Trading Post for the wastewater treatment facility located on private land in Cameron (Township 29N, Range 9E, Section 22), Coconino County, Arizona.

  18. 75 FR 20857 - Endangered Species Recovery Permit Applications

    Science.gov (United States)

    2010-04-21

    ..., Wheat Ridge, Colorado. The applicant requests an amendment to an existing permit (October 7, 2002, 67 FR... (Solano grass) and Cordylanthus palmatus (palmate-bracted bird's-beak) from Federal lands in...

  19. Wesco Operating, Inc. – Maverick Springs NPDES Permit

    Science.gov (United States)

    Under NPDES permit WY-0000469, Wesco Operating, Inc. - Maverick Springs is authorized to discharge from its wastewater treatment facility located in Fremont County, Wyoming to a tributary to Five Mile Creek.

  20. Marathon Oil Company – Maverick Springs NPDES Permit

    Science.gov (United States)

    Under NPDES permit WY-0000779, the Marathon Oil Company – Maverick Springs is authorized to discharge from its wastewater treatment facility located in Fremont County, Wyoming to a tributary to Five Mile Creek.

  1. Crow Municipal Rural & Industrial Pilot Water Treatment Plant NPDES Permit

    Science.gov (United States)

    Under NPDES permit MT-0031827, the Crow Indian Tribe is authorized to discharge from the Crow Municipal Rural & Industrial (MR&I) Pilot Water Treatment Plant in Bighorn County, Montana to the Bighorn River.

  2. 75 FR 20621 - Endangered and Threatened Wildlife and Plants; Permits

    Science.gov (United States)

    2010-04-20

    ... Fish and Wildlife Service ; Endangered and Threatened Wildlife and Plants; Permits AGENCY: Fish and... applications to conduct certain activities with endangered species. With some exceptions, the Endangered Species Act (Act) prohibits activities with endangered and threatened species unless a Federal...

  3. 2015: Special Use Permits : Rocky Mountain Arsenal NWR Complex

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This reference is a collection of Special Use Permits originating from the Rocky Mountain Arsenal NWR Complex. The Complex consists of Rocky Mountain Arsenal NWR,...

  4. Butte County Air Quality Management District Stationary Source Permits

    Science.gov (United States)

    U.S. EPA Public Notice: EPA is finalizing action on three permitting rules submitted as a revision to the Butte County Air Quality Management District (BCAQMD) portion of the California State Implementation Plan (SIP).

  5. 77 FR 19313 - Endangered Species; Marine Mammals; Issuance of Permits

    Science.gov (United States)

    2012-03-30

    ... endangered species, we found that (1) The application was filed in good faith, (2) The granted permit would... Richmond 77 FR 3493: March 15, 2012. Zoo. January 24, 2012. 694126 National 76 FR 80384; March 15,...

  6. 77 FR 38653 - Endangered Species; Marine Mammals; Issuance of Permits

    Science.gov (United States)

    2012-06-28

    ... endangered species, we found that (1) the application was filed in good faith, (2) the granted permit would.... 58210A Point Defiance Zoo & 77 FR 9687; February May 4, 2012. Aquarium. 17, 2012. 65782A, 65783A,...

  7. 76 FR 27660 - Endangered Species; Marine Mammals; Issuance of Permits

    Science.gov (United States)

    2011-05-12

    ... endangered species, we found that (1) The application was filed in good faith, (2) The granted permit would... Zoological 76 FR 12990; March 9, April 21, 2011. Society dba 2011. Brookfield Zoo. 24269A Chelonian...

  8. 77 FR 58406 - Endangered Species; Marine Mammals; Issuance of Permits

    Science.gov (United States)

    2012-09-20

    ... endangered species, we found that (1) The application was filed in good faith, (2) The granted permit would... Zoo and 77 FR 46514; August 3, August 27, 2012. Garden. 2012. Marine Mammals Receipt of...

  9. 76 FR 60863 - Endangered Species; Marine Mammals; Issuance of Permits

    Science.gov (United States)

    2011-09-30

    ... endangered species, we found that (1) The application was filed in good faith, (2) The granted permit would... September 22, 2011. Society dba Gladys 17, 2011. Porter Zoo. Marine Mammals 48293A Red Rock Films 76...

  10. 77 FR 74506 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2012-12-14

    ... conservation responsibilities for affected species, and in consideration of section 10(a)(1)(A) of the... before final action is taken. III. Permit Applications A. Endangered Species Applicant: Palm Beach Zoo...

  11. 77 FR 49453 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2012-08-16

    .... Applicant: Rancho Milagro, San Diego, TX; PRT-80160A The applicant requests a captive-bred wildlife.... Applicant: Rancho Milagro, San Diego, TX; PRT-80158A The applicant requests a permit authorizing...

  12. Administration of the NPDES Stormwater Permit Program in ...

    Science.gov (United States)

    2017-08-28

    In New England, the NPDES Stormwater Permit Program is administered by state government in Connecticut, Maine, Rhode Island, and Vermont ('authorized states') or by EPA, in partnership with the states, in Massachusetts and New Hampshire ('non-authorized states').

  13. 9 CFR 73.10 - Permitted dips; substances allowed.

    Science.gov (United States)

    2010-01-01

    ... flowers of sulphur or sulphur flour to 100 gallons of water; or a specifically permitted proprietary brand... such period as may be required under the Federal Meat Inspection Act (21 U.S.C., Supp. III, 601 et seq...

  14. 75 FR 30428 - Receipt of Applications for Permit

    Science.gov (United States)

    2010-06-01

    ... of Michigan, Ann Arbor, MI; PRT-10640A The applicant requests a permit to import dried skin samples... (Lontra feline), manatees (Trichechus spp.), dugongs (Dugong dugon), polar bears (Ursus maritimus)...

  15. 9 CFR 82.11 - Issuance of permits.

    Science.gov (United States)

    2010-01-01

    ... INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS EXOTIC NEWCASTLE DIS- EASE (END) AND CHLAMYDIOSIS Exotic Newcastle Disease (END) § 82.11 Issuance of permits. (a) Application for...

  16. 50 CFR 300.114 - Dealer permits and preapproval.

    Science.gov (United States)

    2010-10-01

    ... FISHERIES REGULATIONS Antarctic Marine Living Resources § 300.114 Dealer permits and preapproval. (a... calculating administrative costs of special products and services. The fee is specified with the...

  17. EPA Office of Water (OW): Pollutant Discharge Permit Status

    Data.gov (United States)

    U.S. Environmental Protection Agency — U.S. States (Generalized) represents the 50 states and the District of Columbia of the United States joined with data from the NPDES Permit Backlog Report for the...

  18. 77 FR 64121 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2012-10-18

    ... tigers (Panthera tigris) for the purpose of enhancement of the survival of the species from Alexander... of their permits to re-export and re-import three captive born tigers (Panthera tigris) to...

  19. 2014: Special Use Permits : Rocky Mountain Arsenal NWR Complex

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This reference is a collection of Special Use Permits originating from the Rocky Mountain Arsenal NWR Complex. The Complex consists of Rocky Mountain Arsenal NWR,...

  20. 2017: Special Use Permits : Rocky Mountain Arsenal NWR Complex

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This reference is a collection of Special Use Permits originating from the Rocky Mountain Arsenal NWR Complex. The Complex consists of Rocky Mountain Arsenal NWR,...

  1. 78 FR 69849 - Issuance of an Experimental Use Permit

    Science.gov (United States)

    2013-11-21

    ...: Notice. SUMMARY: EPA has granted an experimental use permit (EUP) to the pesticide applicant Monsanto...-0780). Issuance. Monsanto Company, 800 N. Lindbergh Blvd., St. Louis, MO 63167. This EUP, issued...

  2. 75 FR 28650 - Receipt of Applications for Permit

    Science.gov (United States)

    2010-05-21

    ... Service, George Jordan, Pallid Sturgeon Recovery Coordinator, Billings, MT; PRT-03492A The applicant..., Program Analyst, Branch of Permits, Division of Management Authority. BILLING CODE 4310-55-S...

  3. 40 CFR 124.16 - Stays of contested permit conditions.

    Science.gov (United States)

    2010-07-01

    ...) Uncontested conditions which are not severable from those contested shall be stayed together with the... shall be granted based on the staying of any State-issued permit except at the discretion of the...

  4. 76 FR 33703 - Endangered Species; Permit No. 16439

    Science.gov (United States)

    2011-06-09

    ...'' from the Features box on the Applications and Permits for Protected Species (APPS) home page, https.... A first subset of fish would be anesthetized and tagged with acoustic transmitters; a second...

  5. 2013: Special Use Permits : Rocky Mountain Arsenal NWR Complex

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This reference is a collection of Special Use Permits originating from the Rocky Mountain Arsenal NWR Complex. The Complex consists of Rocky Mountain Arsenal NWR,...

  6. 77 FR 36571 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2012-06-19

    ...; PRT-00568A The applicant requests a permit to import: hair and tissue samples collected noninvasively... Lake, WI; PRT-74920A Applicant: Joseph Sultan, Belmont, MA; PRT-73620A Applicant: Gary Young, Windfield...

  7. 75 FR 66123 - Endangered Species Recovery Permit Applications

    Science.gov (United States)

    2010-10-27

    ... R. Huffman, Phoenix, Arizona. The applicant requests a permit to take (survey by pursuit) the Quino.... Michael M. Long, Acting Regional Director, Region 8, Sacramento, California. BILLING CODE 4310-55-P...

  8. 2008: Special Use Permits : Rocky Mountain Arsenal NWR Complex

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This reference is a collection of Special Use Permits originating from the Rocky Mountain Arsenal NWR Complex. The Complex consists of Rocky Mountain Arsenal NWR,...

  9. 77 FR 3493 - Endangered Species Receipt of Applications for Permit

    Science.gov (United States)

    2012-01-24

    ..., Moseley, VA; PRT-57466A. The applicant requests a permit to import 6 female captive-born cheetahs (Acinonyx jubatus jubatus) from De Wildt Cheetah Breeding Centre, De Wildt, South Africa for the purpose...

  10. 29 CFR 1910.146 - Permit-required confined spaces.

    Science.gov (United States)

    2010-07-01

    ... which they remove dummies, manikins, or actual persons from the actual permit spaces or from... approximately 4 feet (1.22 m) in the direction of travel and to each side. If a sampling probe is used,...

  11. 2011: Special Use Permits : Rocky Mountain Arsenal NWR Complex

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This reference is a collection of Special Use Permits originating from the Rocky Mountain Arsenal NWR Complex. The Complex consists of Rocky Mountain Arsenal NWR,...

  12. State Waste Discharge Permit application: 400 Area Septic System

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    As part of the Hanford Federal Facility Agreement and Consent Order negotiations, the US Department of Energy, Richland Operations Office, the US Environmental Protection Agency, and the Washington State Department of Ecology agreed that liquid effluent discharges to the ground on the Hanford Site which affects groundwater or has the potential to affect groundwater would be subject to permitting under the structure of Chapter 173-216 (or 173-218 where applicable) of the Washington Administrative Code, the State Waste Discharge Permit Program. This document constitutes the State Waste Discharge Permit application for the 400 Area Septic System. The influent to the system is domestic waste water. Although the 400 Area Septic System is not a Public Owned Treatment Works, the Public Owned Treatment Works application is more applicable than the application for industrial waste water. Therefore, the State Waste Discharge Permit application for Public Owned Treatment Works Discharges to Land was used.

  13. Hanford facility dangerous waste permit application, PUREX storage tunnels

    Energy Technology Data Exchange (ETDEWEB)

    Haas, C. R.

    1997-09-08

    The Hanford Facility Dangerous Waste Permit Application is considered to be a single application organized into a General Information Portion (document number DOE/RL-91-28) and a Unit-Specific Portion. The scope of the Unit-Specific Portion is limited to Part B permit application documentation submitted for individual, `operating` treatment, storage, and/or disposal units, such as the PUREX Storage Tunnels (this document, DOE/RL-90-24).

  14. Hanford facility dangerous waste permit application, PUREX storage tunnels

    Energy Technology Data Exchange (ETDEWEB)

    Price, S.M.

    1997-09-08

    The Hanford Facility Dangerous Waste Permit Application is considered to be a single application organized into a General Information Portion (document number DOE/RL-91-28) and a Unit-Specific Portion. The scope of the Unit-Specific Portion is limited to Part B permit application documentation submitted for individual, operating treatment, storage, and/or disposal units, such as the PUREX Storage Tunnels (this document, DOE/RL-90-24). Both the General Information and Unit-Specific portions of the Hanford Facility Dangerous Waste Permit Application address the content of the Part B permit application guidance prepared by the Washington State Department of Ecology (Ecology 1996) and the US Environmental Protection Agency (40 Code of Federal Regulations 270), with additional information needs defined by the Hazardous and Solid Waste Amendments and revisions of Washington Administrative Code 173-303. For ease of reference, the Washington State Department of Ecology alpha-numeric section identifiers from the permit application guidance documentation (Ecology 1996) follow, in brackets, the chapter headings and subheadings. A checklist indicating where information is contained in the PUREX Storage Tunnels permit application documentation, in relation to the Washington State Department of Ecology guidance, is located in the Contents Section. Documentation contained in the General Information Portion is broader in nature and could be used by multiple treatment, storage, and/or disposal units (e.g., the glossary provided in the General Information Portion). Wherever appropriate, the PUREX Storage Tunnels permit application documentation makes cross-reference to the General Information Portion, rather than duplicating text. Information provided in this PUREX Storage Tunnels permit application documentation is current as of April 1997.

  15. NPDES Water Permit Program in New England | US EPA

    Science.gov (United States)

    2017-04-10

    NPDES stands for National Pollutant Discharge Elimination System. Under the NPDES program, all municipal, industrial and commercial facilities that discharge wastewater directly from a point source (a discrete conveyance such as a pipe, ditch or channel) into a receiving waterbody (lake, river, ocean) are issued an NPDES permit. Facilities that discharge wastewater to a publicly owned treatment works (POTW), which in turn discharges into the receiving waterbody, are not subject to NPDES permits; rather they are controlled by the national pretreatment program.

  16. Transportation of Large Wind Components: A Permitting and Regulatory Review

    Energy Technology Data Exchange (ETDEWEB)

    Levine, Aaron [National Renewable Energy Lab. (NREL), Golden, CO (United States); Cook, Jeff [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-09-01

    This report summarizes permitting and regulatory issues associated with transporting wind turbine blades, towers, and nacelles as well as large transformers (wind components). These wind components are commonly categorized as oversized and overweight (OSOW) and require specific permit approvals from state and local jurisdictions. The report was developed based on a Quadrennial Energy Review (QER) recommendation on logistical requirements for the transportation of 'oversized or high-consequence energy materials, equipment, and components.'

  17. Individual Tradable Permit Market And Traffic Congestion: An Experimental Study

    Directory of Open Access Journals (Sweden)

    Kean Siang Ch’ng

    2012-01-01

    Full Text Available The increasing vehicular traffic and the consequent over-consumption have emerged as the results of rapid motorization and urbanization throughout the world. Variety of measures have been attempted to deal with the vehicular problems. This paper was intended to investigate the potential of an individual tradable permit system in an experimental two-sided repeated double auction market to overcome over-consumption through road demand management. The auction began with the local authority distributing access rights to the vehicular owners. The owners could either use up the permit or to purchase permit from the open market. The latter allowed usage beyond the owner’s quota. The system showed that traders exhibited strong dependence on reservation price and there were significant transfers of permit from low-value users to high-value users: low-value owners sold access rights to high-value owners. Consequently, in the peak hours, the permit price increased owing to high demand, so the cost of using the road was high during congestion. This created incentive for low-value drivers to postpone their trips and resold permits in the peak hours to gain profit. The results showed the delayer pays principle, in which drivers who valued highly had to pay drivers who were willing to stay off the road during peak hours.

  18. 25 CFR 166.219 - How do I acquire a permit through negotiation?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How do I acquire a permit through negotiation? 166.219... PERMITS Permit Requirements Obtaining A Permit § 166.219 How do I acquire a permit through negotiation? (a...) Upon the conclusion of negotiations with the Indian landowners or their representatives, and...

  19. Hand Infections

    Science.gov (United States)

    ... a skin infection that can cause skin redness, warmth, and pain. People with cellulitis may have a ... cause the skin around the nail to be red, swollen, and tender. If the infection is treated ...

  20. Staph Infections

    Science.gov (United States)

    ... Culture Household Safety: Preventing Cuts Dealing With Cuts Osteomyelitis Tetanus First Aid: Skin Infections Toxic Shock Syndrome ... Abscess Paronychia Dealing With Cuts and Wounds Cellulitis Osteomyelitis Impetigo Staph Infections MRSA Cuts, Scratches, and Scrapes ...

  1. Streptococcal Infections

    Science.gov (United States)

    ... red rash on the body. Impetigo - a skin infection Toxic shock syndrome Cellulitis and necrotizing fasciitis (flesh-eating disease) Group B strep can cause blood infections, pneumonia and meningitis in newborns. A screening test ...

  2. Tapeworm Infection

    Science.gov (United States)

    Diseases and Conditions Tapeworm infection By Mayo Clinic Staff Tapeworm infection is caused by ingesting food or water contaminated with tapeworm eggs or larvae. If you ingest certain tapeworm eggs, they can migrate outside ...

  3. Infection Control

    Science.gov (United States)

    ... lives are lost because of the spread of infections in hospitals. Health care workers can take steps ... of infectious diseases. These steps are part of infection control. Proper hand washing is the most effective ...

  4. Tinea Infections

    Science.gov (United States)

    ... The skin may become itchy and red, with blisters and cracking of the skin. The infection may ... my sheets and towels every day? ResourcesDiagnosis and Management of Common Tinea Infections by SL Noble, Pharm. ...

  5. Campylobacter Infections

    Science.gov (United States)

    Campylobacter infection is a common foodborne illness. You get it from eating raw or undercooked poultry. You ... whether you need to take antibiotics. To prevent campylobacter infection, cook poultry thoroughly. Use a separate cutting ...

  6. Spinal infections.

    Science.gov (United States)

    Tay, Bobby K-B; Deckey, Jeffrey; Hu, Serena S

    2002-01-01

    Spinal infections can occur in a variety of clinical situations. Their presentation ranges from the infant with diskitis who is unwilling to crawl or walk to the adult who develops an infection after a spinal procedure. The most common types of spinal infections are hematogenous bacterial or fungal infections, pediatric diskitis, epidural abscess, and postoperative infections. Prompt and accurate diagnosis of spinal infections, the cornerstone of treatment, requires a high index of suspicion in at-risk patients and the appropriate evaluation to identify the organism and determine the extent of infection. Neurologic function and spinal stability also should be carefully evaluated. The goals of therapy should include eradicating the infection, relieving pain, preserving or restoring neurologic function, improving nutrition, and maintaining spinal stability.

  7. Anaerobic Infections

    Science.gov (United States)

    ... on the face and neck, sometimes after a dental infection or procedure such as a tooth extraction or ... adults of all ages. The most common are dental infections, inflammation of the abdominal lining (peritonitis), and abscesses ...

  8. Hantavirus Infections

    Science.gov (United States)

    ... but deadly viral infection. It is spread by mice and rats. They shed the virus in their ... breathe infected air or come into contact with rodents or their urine or droppings. You cannot catch ...

  9. Rotavirus Infections

    Science.gov (United States)

    Rotavirus is a virus that causes gastroenteritis. Symptoms include severe diarrhea, vomiting, fever, and dehydration. Almost all ... the U.S. are likely to be infected with rotavirus before their 5th birthday. Infections happen most often ...

  10. 77 FR 55475 - Federal Acquisition Regulation; Information Collection; Permits, Authorities, or Franchises

    Science.gov (United States)

    2012-09-10

    ... Regulation; Information Collection; Permits, Authorities, or Franchises AGENCY: Department of Defense (DOD... previously approved information collection requirement concerning permits, authorities, or franchises for..., Permits, Authorities, or Franchises, by any of the following methods: Regulations.gov :...

  11. 78 FR 5451 - Federal Acquisition Regulation; Submission for OMB Review; Permits, Authorities, or Franchises

    Science.gov (United States)

    2013-01-25

    ... Regulation; Submission for OMB Review; Permits, Authorities, or Franchises AGENCIES: Department of Defense... previously approved information collection requirement concerning permits, authorities, or franchises for... 9000- 0053, Permits, Authorities, or Franchises, by any of the following methods:...

  12. Building Permits, Building Permits exist in tabular form. We link on the PIN # to get parcel boundaries with building permits. The parcels and the building permits table join is a many to many relationship., Published in 2010, 1:2400 (1in=200ft) scale, Effingham County Government.

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Building Permits dataset current as of 2010. Building Permits exist in tabular form. We link on the PIN # to get parcel boundaries with building permits. The parcels...

  13. Tradable permits and competitive strength; Wettbewerbspolitische Aspekte von Zertifikaten

    Energy Technology Data Exchange (ETDEWEB)

    Weimann, J. [Magdeburg Univ. (Germany). Lehrstuhl fuer Volkswirtschaftslehre III

    1998-12-31

    Tradable permits are a potential mean to solve the problem of missing, property rights for environmental goods. There are some arguments against this solution which claim that permits could be able to restrict competition. To discuss these arguments, we firstly deal with the problem of market power in the permit market and secondly with possible restrictions of competition in input and output markets. The result is: Markets for tradable permits are not really in danger to reduce the competitiveness of relevant markets. Finally, a new argument against permits, which is a side effect of the double-dividend debate, is discussed. (orig.) [Deutsch] Zertifikate sind in der Lage, das Problem fehlender Eigentumsrechte fuer Umweltgueter zu loesen. Einige der Argumente gegen diese Loesung stellen darauf ab, dass durch Zertifikate Wettbewerbseinschraenkungen ausgeloest werden koennen. Um diese Argumente diskutieren zu koennen werden zunaechst Marktmacht im Zertifikatmarkt und dann Wettbewerbsbeschraenkungen auf Input- und Outputmaerkten untersucht. Das Ergebnis ist: Von Zertifikatmaerkten duerften kaum ernsthafte Wettbewerbseinschraenkungen ausgehen. Abschliessend wird ein neueres Argument gegen die Zertifikatloesung diskutiert, das als Nebeneffekt der Debatte um die Doppelte Dividende entstanden ist. (orig.)

  14. Hanford facility dangerous waste permit application, general information portion

    Energy Technology Data Exchange (ETDEWEB)

    Price, S.M., Westinghouse Hanford

    1996-07-29

    The `Hanford Facility Dangerous Waste Permit Application` is considered to be a single application organized into a General Information Portion (this document, DOE/RL-91-28) and a Unit- Specific Portion. The scope of the General Information Portion includes information that could be used to discuss operating units, units undergoing closure, or units being dispositioned through other options. Documentation included in the General Information Portion is broader in nature and could be used by multiple treatment, storage, and/or disposal units. A checklist indicating where information is contained in the General Information Portion, in relation to the Washington State Department of Ecology guidance documentation, is located in the Contents Section. The intent of the General Information Portion is: (1) to provide an overview of the Hanford Facility; and (2) to assist in streamlining efforts associated with treatment, storage, and/or disposal unit-specific Part B permit application, preclosure work plan, closure work plan, closure plan, closure/postclosure plan, or postclosure permit application documentation development, and the `Hanford Facility Resource Conservation and Recovery Act Permit` modification process. Revision 2 of the General Information Portion of the `Hanford Facility Dangerous Waste Permit Application` contains information current as of May 1, 1996. This document is a complete submittal and supersedes Revision 1.

  15. Qualitative identification of permitted and non-permitted colour additives in food products.

    Science.gov (United States)

    Harp, Bhakti Petigara; Miranda-Bermudez, Enio; Baron, Carolina I; Richard, Gerald I

    2012-01-01

    Colour additives are dyes, pigments or other substances that can impart colour when added or applied to food, drugs, cosmetics, medical devices, or the human body. The substances must be pre-approved by the US Food and Drug Administration (USFDA) and listed in Title 21 of the US Code of Federal Regulations before they may be used in products marketed in the United States. Some also are required to be batch certified by the USFDA prior to their use. Both domestic and imported products sold in interstate commerce fall under USFDA jurisdiction, and the USFDA's district laboratories use a combination of analytical methods for identifying or confirming the presence of potentially violative colour additives. We have developed a qualitative method for identifying 17 certifiable, certification exempt, and non-permitted colour additives in various food products. The method involves extracting the colour additives from a product and isolating them from non-coloured components with a C(18) Sep-Pak cartridge. The colour additives are then separated and identified by liquid chromatography (LC) with photodiode array detection, using an Xterra RP18 column and gradient elution with aqueous ammonium acetate and methanol. Limits of detection (LODs) ranged from 0.02 to 1.49 mg/l. This qualititative LC method supplements the visible spectrophotometric and thin-layer chromatography methods currently used by the USFDA's district laboratories and is less time-consuming and requires less solvent compared to the other methods. The extraction step in the new LC method is a simple and an efficient process that can be used for most food types.

  16. Hanford facility dangerous waste permit application, general information portion

    Energy Technology Data Exchange (ETDEWEB)

    Hays, C.B.

    1998-05-19

    The Hanford Facility Dangerous Waste Permit Application is considered to be a single application organized into a General Information Portion (document number DOE/RL-91-28) and a Unit-Specific Portion. Both the General Information and Unit-Specific portions of the Hanford Facility Dangerous Waste Permit Application address the content of the Part B permit application guidance prepared by the Washington State Department of Ecology (Ecology 1996) and the U.S. Environmental Protection Agency (40 Code of Federal Regulations 270), with additional information needed by the Hazardous and Solid Waste Amendments and revisions of Washington Administrative Code 173-303. Documentation contained in the General Information Portion is broader in nature and could be used by multiple treatment, storage, and/or disposal units (e.g., the glossary provided in this report).

  17. Industrial fuel gas demonstration plant program. Construction permit. Compliance plan. (Deliverable No. 31)

    Energy Technology Data Exchange (ETDEWEB)

    1979-01-01

    The objective of this compliance plan is to insure that all required permits are filed and obtained prior to the start of construction of the U-gas demonstration plant. This plan addresses the permits in the following areas: construction, electrical, mechanical, plumbing, federal aviation lighting, and as-required permits. Each permit area is introduced by a brief summary of the permits required and the significant circumstances and/or conditions affecting permit acquisition. Each permit is then discussed in detail according to a format which includes the following: brief introduction of permit, responsible regulator agency, other potential reviewing agency(s), information needed for permit, filing procedures, normal review period, permit duration period, and permit fees. Copies of the actual application forms, guidelines for completing the applications, statements on required information and agency contacts are contained in the Appendices.

  18. Myxoma virus suppresses proliferation of activated T lymphocytes yet permits oncolytic virus transfer to cancer cells.

    Science.gov (United States)

    Villa, Nancy Y; Wasserfall, Clive H; Meacham, Amy M; Wise, Elizabeth; Chan, Winnie; Wingard, John R; McFadden, Grant; Cogle, Christopher R

    2015-06-11

    Allogeneic hematopoietic cell transplant (allo-HCT) can be curative for certain hematologic malignancies, but the risk of graft-versus-host disease (GVHD) is a major limitation for wider application. Ideally, strategies to improve allo-HCT would involve suppression of T lymphocytes that drive GVHD while sparing those that mediate graft-versus-malignancy (GVM). Recently, using a xenograft model, we serendipitously discovered that myxoma virus (MYXV) prevented GVHD while permitting GVM. In this study, we show that MYXV binds to resting, primary human T lymphocytes but will only proceed into active virus infection after the T cells receive activation signals. MYXV-infected T lymphocytes exhibited impaired proliferation after activation with reduced expression of interferon-γ, interleukin-2 (IL-2), and soluble IL-2Rα, but did not affect expression of IL-4 and IL-10. MYXV suppressed T-cell proliferation in 2 patterns (full vs partial) depending on the donor. In terms of GVM, we show that MYXV-infected activated human T lymphocytes effectively deliver live oncolytic virus to human multiple myeloma cells, thus augmenting GVM by transfer of active oncolytic virus to residual cancer cells. Given this dual capacity of reducing GVHD plus increasing the antineoplastic effectiveness of GVM, ex vivo virotherapy with MYXV may be a promising clinical adjunct to allo-HCT regimens.

  19. Towards tradable permits for filamentous green algae pollution.

    Science.gov (United States)

    de Lange, W J; Botha, A M; Oberholster, P J

    2016-09-01

    Water pollution permit systems are challenging to design and implement. Operational systems that has maintained functionality remains few and far between, particularly in developing countries. We present current progress towards developing such a system for nutrient enrichment based water pollution, mainly from commercial agriculture. We applied a production function approach to first estimate the monetary value of the impact of the pollution, which is then used as reference point for establishing a reserve price for pollution permits. The subsequent market making process is explained according to five steps including permit design, terms, conditions and transactional protocol, the monitoring system, piloting and implementation. The monetary value of the impact of pollution was estimated at R1887 per hectare per year, which not only provide a "management budget" for filamentous green algae mitigation strategies in the study area, but also enabled the calculation of a reserve price for filamentous green algae pollution permits, which was estimated between R2.25 and R111 per gram filamentous algae and R8.99 per gram at the preferred state. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. 75 FR 2561 - Receipt of Applications for Permit

    Science.gov (United States)

    2010-01-15

    ... purpose of scientific research. This notification covers activities to be conducted by the applicant over... conservation education. The permit numbers and animals are: 080731, Jazz; 716917, Betty. This notification covers activities to be conducted by the applicant over a three-year period and the import of any...

  1. 40 CFR 52.1988 - Air contaminant discharge permits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Air contaminant discharge permits. 52.1988 Section 52.1988 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Oregon § 52.1988 Air...

  2. 78 FR 38731 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2013-06-27

    ... (Neofelis nebulosa), brown hyena (Parahyaena brunnea), and cheetah (Acinonyx jubatus), to enhance the... amendment of their permit to import one captive-bred male cheetah (Acinonyx jubatus) from the Hoedspruit Endangered Species Center instead of the De Wildt Cheetah Breeding Center, South Africa, for the purpose of...

  3. 50 CFR 21.21 - Import and export permits.

    Science.gov (United States)

    2010-10-01

    ... (Convention on International Trade in Endangered Species of Wild Fauna and Flora)). (3) Each raptor must be... International Trade in Endangered Species of Wild Fauna and Flora (CITES)). (b) Exception to the import permit..., Exportation, and Transportation of Wildlife); (3) 15......

  4. 31 CFR 11.6 - Terms of permit.

    Science.gov (United States)

    2010-07-01

    ..., periodicals, publications, confections, tobacco products, foods, beverages, chances for any lottery authorized... responsibilities set forth in 34 CFR 395.35 (a); (b) The permit shall be issued for an indefinite period of time... the bureau on-site property management officer of the appropriate Treasury bureau and the...

  5. 76 FR 20004 - Endangered Species Recovery Permit Applications

    Science.gov (United States)

    2011-04-11

    ... conjunction with surveys and population monitoring activities in Ventura County, California, for the purpose... Station, Henderson, Nevada, California. The applicant requests a permit to remove/reduce to possession the Eureka Valley dune grass (Swallenia alexandrae) and Eureka Dunes evening primrose (Oenothera...

  6. 50 CFR 16.22 - Injurious wildlife permits.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false Injurious wildlife permits. 16.22 Section 16.22 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR TAKING, POSSESSION, TRANSPORTATION, SALE, PURCHASE, BARTER, EXPORTATION, AND IMPORTATION OF WILDLIFE...

  7. 40 CFR 266.102 - Permit standards for burners.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Hazardous Waste Burned in Boilers and Industrial Furnaces § 266.102 Permit standards... that the hazardous waste, other fuels, and industrial furnace feedstocks fired into the boiler or...

  8. 75 FR 30425 - Endangered and Threatened Species Permit Applications

    Science.gov (United States)

    2010-06-01

    ... Chief, Endangered Species Division, Ecological Services, P.O. Box 1306, Room 6034, Albuquerque, NM 87103... Ave., SW., Room 6034, Albuquerque, NM. Please refer to the respective permit number for each... Species Division, P.O. Box 1306, Albuquerque, NM 87103; (505) 248-6920. SUPPLEMENTARY INFORMATION:...

  9. 19 CFR 111.2 - License and district permit required.

    Science.gov (United States)

    2010-04-01

    ... of attorney for that purpose. The broker is not required to file the power of attorney with the port... this section, the broker must exercise sufficient supervision of the employee to ensure proper conduct... 19 Customs Duties 1 2010-04-01 2010-04-01 false License and district permit required....

  10. State waste discharge permit application, 200-E chemical drain field

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    As part of the Hanford Federal Facility Agreement and Consent Order negotiations (Ecology et al. 1994), the US Department of Energy, Richland Operations Office, the US Environmental Protection Agency, and the Washington State Department of Ecology agreed that liquid effluent discharges to the ground on the Hanford Site which affect groundwater or have the potential to affect ground would be subject to permitting under the structure of Chapter 173-216 (or 173-218 where applicable) of the Washington Administrative Code, the State Waste Discharge Permit Program. As a result of this decision, the Washington State Department of Ecology and the US Department of Energy, Richland Operations Office entered into Consent Order No. DE 91NM-177, (Ecology and DOE-RL 1991). The Consent Order No. DE 91NM-177 requires a series of permitting activities for liquid effluent discharges. This document presents the State Waste Discharge Permit (SWDP) application for the 200-E Chemical Drain Field. Waste water from the 272-E Building enters the process sewer line directly through a floor drain, while waste water from the 2703-E Building is collected in two floor drains, (north and south) that act as sumps and are discharged periodically. The 272-E and 2703-E Buildings constitute the only discharges to the process sewer line and the 200-E Chemical Drain Field.

  11. 75 FR 34445 - Audit Program for Texas Flexible Permit Holders

    Science.gov (United States)

    2010-06-17

    ... regulatory stability for holders of Texas flexible permits. EPA is requesting informal comment on the Audit... implementation of the Audit Program at its discretion, as warranted. DATES: All comments should be submitted by...: Submit comments on the Audit Program, identified by Docket ID No. EPA-R06-OAR-2010-0510, by one of the...

  12. 12 CFR 348.4 - Interlocking relationships permitted by statute.

    Science.gov (United States)

    2010-01-01

    ... OF GENERAL POLICY MANAGEMENT OFFICIAL INTERLOCKS § 348.4 Interlocking relationships permitted by...); (c) A credit union being served by a management official of another credit union; (d) A depository... Loan bank or any other bank organized solely to serve depository institutions (a bankers' bank)...

  13. 75 FR 11193 - Endangered Wildlife and Plants; Permits

    Science.gov (United States)

    2010-03-10

    ... Fish and Wildlife Service Endangered Wildlife and Plants; Permits AGENCY: Fish and Wildlife Service... survival activities for a plant that was recently added to the List of Endangered and Threatened Plants (Phyllostegia hispida). The Endangered Species Act of 1973, as amended (Act), requires that we solicit...

  14. 75 FR 20622 - Endangered Wildlife and Plants; Permits

    Science.gov (United States)

    2010-04-20

    ... Fish and Wildlife Service Endangered Wildlife and Plants; Permits AGENCY: Fish and Wildlife Service... accordance with the requirements of the Endangered Species Act of 1973, as amended (Act), we, the U.S. Fish... enhancement of survival activities with endangered species. DATES: To ensure consideration, please send...

  15. 75 FR 28278 - Endangered Wildlife and Plants; Permits

    Science.gov (United States)

    2010-05-20

    ... Fish and Wildlife Service Endangered Wildlife and Plants; Permits AGENCY: Fish and Wildlife Service... accordance with the requirements of the Endangered Species Act of 1973, as amended (Act), we, the U.S. Fish... enhancement of survival activities with endangered species. DATES: To ensure consideration, please send...

  16. 19 CFR 111.37 - Misuse of license or permit.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Misuse of license or permit. 111.37 Section 111.37 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CUSTOMS BROKERS Duties and Responsibilities of Customs Brokers § 111.37 Misuse of license...

  17. 77 FR 3495 - Endangered Species; Marine Mammals; Issuance of Permits

    Science.gov (United States)

    2012-01-24

    ... endangered species, we found that (1) The application was filed in good faith, (2) The granted permit would... 15, 2011. Marine Science Center. 2011. 008519 Zoo Atlanta 75 FR 82409, December March 1, 2011. 30... Zoo..... 76 FR 18239, April 1, May 23, 2011. 2011. 013008 777 Ranch Inc 76 FR 7580, February July...

  18. 77 FR 300 - Endangered Species; Marine Mammals; Issuance of Permits

    Science.gov (United States)

    2012-01-04

    ... endangered species, we found that (1) The application was filed in good faith, (2) The granted permit would... Angeles Zoo and 76 FR 60862; September November 23, 2011. Botanical Gardens. 30, 2011. 56760A Los Angeles Zoo and 76 FR 66954; October December 1, 2011. Botanical Gardens. 28, 2011. 57442A Matthew Bindon...

  19. 78 FR 48712 - Endangered Species; Marine Mammals; Issuance of Permits

    Science.gov (United States)

    2013-08-09

    ... endangered species, we found that (1) The application was filed in good faith, (2) The granted permit would... 78 FR 9725; February 11, June 14, 2013. the University of 2013. Illinois. 675484 Birmingham Zoo, Inc..... 78 FR 16292; March 14, May 1, 2013. 2013. 036218 Brevard Zoo 78 FR 1771; March 22, May 1, 2013....

  20. 78 FR 42540 - Endangered and Threatened Species; Permits

    Science.gov (United States)

    2013-07-16

    ... issued only after we determined that it was applied for in good faith, that granting the permit would not.../31/2018 NATIONAL ZOO 051828 7/6/2012 5/30/2016 NEBRASKA DEPARTMENT OF ROADS 186282 1/15/2013...

  1. 78 FR 37565 - Endangered Species; Issuance of Permits

    Science.gov (United States)

    2013-06-21

    .... For each permit for an endangered species, we found that (1) The application was filed in good faith... January 4, 2013. 16, 2012. 677573 Reid Park Zoo 77 FR 68809; November January 4, 2013. 16, 2012. 002692 Springhill Wildlife 77 FR 68809; November January 4, 2013. Park. 16, 2012. 680356 Utah's Hogle Zoo..........

  2. 77 FR 34061 - Endangered Species; Issuance of Permits

    Science.gov (United States)

    2012-06-08

    ... (1) The application was filed in good faith, (2) The granted permit would not operate to the... 6816; February 9, April 11, 2012. 2012. 781629 Zoo Boise 77 FR 6816; February 9, April 11, 2012. 2012. 678366 Phoenix Zoo 77 FR 6816; February 9, April 11, 2012. 2012. 60391A Hatada Enterprises,...

  3. 78 FR 27255 - Endangered Species; Issuance of Permits

    Science.gov (United States)

    2013-05-09

    ... was filed in good faith, (2) The granted permit would not operate to the disadvantage of the.... 209126 Zoo of Acadiana, L.L.C.. 77 FR 15383; March 15, May 4, 2012. 2012. 66629A Forest Land L.L.C...; March 26, May 4, 2012. 2012. 671151 Maryland Zoo in 77 FR 19311; March 30, May 4, 2012. Baltimore....

  4. 78 FR 34120 - Endangered Species; Marine Mammals; Issuance of Permits

    Science.gov (United States)

    2013-06-06

    ... endangered species, we found that (1) the application was filed in good faith, (2) The granted permit would..., 2012. 2012. 704654 Scovill Zoo 77 FR 51819; August 27, October 31, 2012. 2012. 81326A Gomez Development.... 2012. 84250A Burmont, Inc 77 FR 61627; October 10, November 16, 2012. 2012. 681252 Cincinnati...

  5. 76 FR 32222 - Endangered Species; Marine Mammals; Issuance of Permits

    Science.gov (United States)

    2011-06-03

    ... endangered species, we found that (1) The application was filed in good faith, (2) The granted permit would.......... 76 FR 20705; April May 19, 2011. 13, 2011. 37443A Metro Richmond Zoo... 76 FR 18239; April 1, May 23... University, 75 FR 69701; November March 29, 2011. Schubot Exotic Bird 15, 2010. Health Center. 008519...

  6. 78 FR 12780 - Endangered Species; Marine Mammals; Issuance of Permits

    Science.gov (United States)

    2013-02-25

    ... endangered species, we found that (1) The application was filed in good faith, (2) The granted permit would... Moore 77 FR 66476; January 14, 2013. November 5, 2012. 84872A Palm Beach Zoo at 77FR 66476; November... Islands November 16, 2012. Regional Office. 89103A Dallas Zoo 77FR 68809; November February 12, 2013....

  7. 75 FR 41235 - Receipt of Applications for Permit

    Science.gov (United States)

    2010-07-15

    .... Background To help us carry out our conservation responsibilities for affected species, the Endangered... Species Applicant: Los Angeles Zoo; Los Angeles, CA; PRT-16655A The applicant requests a permit to export three captive-born brush- tailed bettongs or woylie (Bettongia penincillata) to the Toronto Zoo,...

  8. 75 FR 54909 - Endangered Species Receipt of Applications for Permit

    Science.gov (United States)

    2010-09-09

    ... guarantee that we will be able to do so. II. Background To help us carry out our conservation... applications. ] III. Permit Applications A. Endangered Species Applicant: Los Angeles Zoo and Botanical Gardens..., captive-bred at Toronto Zoo for the purpose of enhancement of the survival of the species....

  9. 78 FR 21627 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2013-04-11

    ... conservation responsibilities for affected species, and in consideration of section 10(a)(1)(A) of the... before final action is taken. III. Permit Applications A. Endangered Species Applicant: Saint Louis Zoo... deceased captive-born Somali wild ass (Equus africanus somalicus) that was held at San Diego Zoo until...

  10. 78 FR 4162 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2013-01-18

    ... conservation responsibilities for affected species, and in consideration of section 10(a)(1)(A) of the.... Applicant: Greenville Zoo, Greenville, SC; PRT-92474A The applicant requests a captive-bred wildlife... species. Applicant: Honolulu Zoo, Honolulu, HI; PRT-94141A The applicant requests a permit...

  11. 50 CFR 404.11 - Permitting procedures and criteria.

    Science.gov (United States)

    2010-10-01

    ... that does not destroy, cause the loss of, or injure Monument resources; and (D) Shall require the... National Wildlife Refuge was designated. (ii) As part of a permit issued pursuant to this paragraph (f)(5... the purposes for which the Midway Atoll National Wildlife Refuge was established. Sustenance fishing...

  12. State Waste Discharge Permit application, 183-N Backwash Discharge Pond

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    As part of the Hanford Federal Facility Agreement and Consent Order negotiations (Ecology et al. 1994), the US Department of Energy, Richland Operations Office, the US Environmental Protection Agency, and the Washington State Department of Ecology agreed that liquid effluent discharges to the ground on the Hanford Site which affect groundwater or have the potential to affect groundwater would be subject to permitting under the structure of Chapter 173--216 (or 173--218 where applicable) of the Washington Administrative Code, the State Waste Discharge Permit Program. As a result of this decision, the Washington State Department of Ecology and the US Department of Energy, Richland Operations Office entered into Consent Order No. DE91NM-177, (Ecology and DOE-RL 1991). The Consent Order No. DE91NM-177 requires a series of permitting activities for liquid effluent discharges. Liquid effluents on the Hanford Site have been classified as Phase I, Phase II, and Miscellaneous Streams. The Consent Order No. DE91NM-177 establishes milestones for State Waste Discharge Permit application submittals for all Phase I and Phase II streams, as well as the following 11 Miscellaneous Streams as identified in Table 4 of the Consent Order No. DE91NM-177.

  13. 78 FR 16292 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2013-03-14

    ... data you include. The comments and recommendations that will be most useful and likely to influence... and foreign commerce, export, and cull of excess scimitar-horned oryx (Oryx dammah), addax (Addax..., Mobile, AL; PRT-98930A The applicant requests a permit to import a sport-hunted trophy of one male...

  14. 78 FR 51816 - Notice of Actions on Special Permit Applications

    Science.gov (United States)

    2013-08-21

    ..., 172.301(c), and 180.205. to authorize ultrasonic Centennial, CO. equipment with a five sensor head... permit Corporation, 172.301(c), and 180.205. to authorize ultrasonic Centennial, CO. equipment with a five sensor head with sensors positioned to perform all required straight and angle beam...

  15. 75 FR 52971 - Receipt of Applications for Permit

    Science.gov (United States)

    2010-08-30

    .... Applicant: Rocky Mountain Wildlife Conservation Center, Keenesburg, CO; PRT-18346A The applicant requests a... endangered species, marine mammals, or both. With some exceptions, the Endangered Species Act (ESA) and Marine Mammal Protection Act (MMPA) prohibits activities with listed species unless a Federal permit...

  16. 78 FR 53157 - Endangered and Threatened Species Permit Applications

    Science.gov (United States)

    2013-08-28

    ... surveys, trap and relocate activities and other research activities for the American burying beetle... permit for research and recovery purposes to conduct presence/absence surveys of American burying beetle... conduct presence/absence surveys of the following animal species and seed collection for the...

  17. Publicly Owned Treatment Works General Permit (POTW GP) ...

    Science.gov (United States)

    2017-04-10

    The Notice of Availability of the final National Pollutant Discharge Elimination System (NPDES) General Permits for the Discharge of Wastewater from Certain Publicly Owned Treatment Works Treatment Plants (POTW Treatment Plants) and Other Treatment Works Treating Domestic Sewage in the Commonwealth of Massachusetts and the State of New Hampshire was published in the Federal Register on July 6, 2011.

  18. Potable Water Treatment Facility General Permit (PWTF GP) ...

    Science.gov (United States)

    2017-04-10

    The Final PWTF GP establishes permit eligibility conditions, Notice of Intent (NOI) requirements, effluent limitations, standards, prohibitions, and best management practices for facilities that discharge to waters in the Commonwealth of Massachusetts (including both Commonwealth and Indian country lands) and the State of New Hampshire.

  19. 12 CFR 711.4 - Interlocking relationships permitted by statute.

    Science.gov (United States)

    2010-01-01

    .... 711.4 Section 711.4 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS MANAGEMENT OFFICIAL INTERLOCKS § 711.4 Interlocking relationships permitted by statute. The... being served by a management official of another credit union; (d) A depository organization that...

  20. 77 FR 20838 - Endangered Species; Receipt of Applications for Permits

    Science.gov (United States)

    2012-04-06

    ... (Panthera tigris tigris). Siberian tiger (Panthera tigris altaica). Snow leopard (Uncia uncia). Cheetah... a 5-year period. Families: Callithricidae. Lemuridae. Hylobatidae. Genus: Panthera. Species: Snow... requests the re-issuance of their permits to re- export and re-import three captive born tigers...

  1. 77 FR 34458 - Pipeline Safety: Requests for Special Permit

    Science.gov (United States)

    2012-06-11

    ..., Alaska. The pipeline is intended to transport natural gas from the oil and gas producers on the Alaskan... received from Norgasco, Inc., and BreitBurn Energy Company LP, two natural gas pipeline operators, seeking... permits from two natural gas pipeline operators, Norgasco, Inc., (``NI''), and BreitBurn Energy Company...

  2. 78 FR 112 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2013-01-02

    ... Canada for the purpose of enhancement of the survival of the species. Applicant: Cinco Canyon Ranch... notification covers activities to be conducted by the applicant over a 5-year period. Applicant: Cinco Canyon... Applicants The following applicants each request a permit to import the sport- hunted trophy of one...

  3. 40 CFR 258.4 - Research, development, and demonstration permits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Research, development, and...) SOLID WASTES CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS General § 258.4 Research, development, and... State may issue a research, development, and demonstration permit for a new MSWLF unit, existing MSWLF...

  4. 50 CFR 21.29 - Falconry standards and falconry permitting.

    Science.gov (United States)

    2010-10-01

    ...) Mississippi, Montana, Oklahoma, Pennsylvania, Texas, or Utah, practice falconry as permitted in these... may need a Federal Migratory Bird Hunting and Conservation Stamp (a “Duck Stamp”), and State, tribal.... (4) Each falconry bird must have access to a pan of clean water unless weather conditions, the perch...

  5. 76 FR 9173 - Proposal To Reissue and Modify Nationwide Permits

    Science.gov (United States)

    2011-02-16

    ... 12, 2007, issue of the Federal Register (72 FR 11092) expire on March 18, 2012. With this Federal... permit process. Thirty of the NWPs proposed for reissuance require pre-construction notification (PCN... impacts to the aquatic environment are minimal. Review of a PCN may also result in the Corps...

  6. 23 CFR 650.807 - Bridges requiring a USCG permit.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Bridges requiring a USCG permit. 650.807 Section 650.807... BRIDGES, STRUCTURES, AND HYDRAULICS Navigational Clearances for Bridges § 650.807 Bridges requiring a USCG... improvement or construction of a bridge over navigable waters except for the exemption exercised by FHWA...

  7. 76 FR 26793 - Pipeline Safety: Request for Special Permit

    Science.gov (United States)

    2011-05-09

    ... Company (Belle Fourche). Belle Fourche is seeking relief from compliance with certain requirements in the... special permit from the Belle Fourche Pipeline Company. Belle Fourche seeks relief from compliance with...: Notice. SUMMARY: Pursuant to the Federal pipeline safety laws, PHMSA is re- publishing this notice to...

  8. 75 FR 66425 - Pipeline Safety: Request for Special Permit

    Science.gov (United States)

    2010-10-28

    ... the Federal Pipeline Safety Laws, PHMSA is publishing this notice of a special permit request we have received from Gulf South Pipeline Company, LP, a natural gas pipeline operator, seeking relief from compliance with certain requirements in the Federal Pipeline Safety Regulations. This notice seeks public...

  9. 30 CFR 773.6 - Public participation in permit processing.

    Science.gov (United States)

    2010-07-01

    ... other parties to the conference and advertised by the regulatory authority in a newspaper of general... permit under § 774.15, shall place an advertisement in a local newspaper of general circulation in the... consecutive weeks. A copy of the advertisement as it will appear in the newspaper shall be submitted to...

  10. Permit trading and stability of international climate agreements

    NARCIS (Netherlands)

    Altamirano-Cabrera, J.C.; Finus, M.

    2006-01-01

    We analyze the implication of different allocation schemes of CO2-emission permits for stability and the success of international climate agreements. Our model combines a game theoretical with an empirical module that comprises 12 world regions and captures important dynamic aspects of the climate c

  11. 40 CFR 147.2918 - Permit application information.

    Science.gov (United States)

    2010-07-01

    ... showing the names, addresses, and date that notice of permit application was given or sent to: (i) The....2918 Section 147.2918 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Osage...

  12. 19 CFR 12.7 - Permits required for importation.

    Science.gov (United States)

    2010-04-01

    ... showing in clear and legible type the product (raw milk, pasteurized milk, raw cream, or pasteurized cream... THE TREASURY SPECIAL CLASSES OF MERCHANDISE Milk and Cream § 12.7 Permits required for importation. (a... Federal Import Milk Act, the importation into the United States of milk and cream is prohibited unless...

  13. 75 FR 79387 - Endangered Species Recovery Permit Applications

    Science.gov (United States)

    2010-12-20

    ... Diego, California. ] The applicant requests a permit to take (survey by pursuit) the Quino checkerspot butterfly (Euphydryas editha quino) in conjunction with surveys throughout the range of the species in...), and take (survey by pursuit) the Quino checkerspot butterfly (Euphydryas editha quino) in conjunction...

  14. 78 FR 16703 - Endangered Species Recovery Permit Applications

    Science.gov (United States)

    2013-03-18

    ... by survey) the Quino checkerspot butterfly (Euphydryas editha quino), and take (survey, capture..., San Diego, California The applicant requests a permit renewal to take (survey by pursuit) the Quino checkerspot butterfly (Euphydryas editha quino) in conjunction with surveys throughout the range of the...

  15. 77 FR 19648 - Receipt of Application for a Permit Modification

    Science.gov (United States)

    2012-04-02

    ... Beach Drive, Miami, FL 33149 , has requested a modification to scientific research Permit No. 13330-01... for an increase in take numbers to 50 individuals from each of the three life stages (neonates, juveniles, and adults) for a total of 150 smalltooth sawfish annually. All research objectives,...

  16. 18 CFR 1312.9 - Terms and conditions of permits.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Terms and conditions of permits. 1312.9 Section 1312.9 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY... and other values and/or resources, to secure work areas, to safeguard other legitimate land uses,...

  17. 5 CFR 2634.1006 - Rollover into permitted property.

    Science.gov (United States)

    2010-01-01

    ... definition of permitted property at § 2634.1003. (b) Internal Revenue Service reporting requirements. An eligible person who elects to defer the recognition of capital gains from the sale of property pursuant to a Certificate of Divestiture must follow Internal Revenue Service rules for reporting the sale...

  18. 75 FR 9314 - Migratory Bird Permits; Control of Purple Swamphens

    Science.gov (United States)

    2010-03-01

    ... with governance of migratory bird permitting in the United States. No other Federal agency has any role... Environmental Policy Act We have analyzed this rule in accordance with the National Environmental Policy Act of... and its territories in which the species may have been introduced. The environmental impacts...

  19. 77 FR 42360 - Actions on Special Permit Applications

    Science.gov (United States)

    2012-07-18

    ...'s Hazardous Material Regulations (49 CFR part 107, Subpart B), notice is hereby given of the actions... Approvals Branch. Nature of special S.P. No. Applicant Regulation(s) permit thereof MODIFICATION SPECIAL............ Walt Disney 49 CFR To authorize the Parks and 173.56(b) and transportation in Resorts U.S., 172.320...

  20. A Candida albicans CRISPR system permits genetic engineering of essential genes and gene families.

    Science.gov (United States)

    Vyas, Valmik K; Barrasa, M Inmaculada; Fink, Gerald R

    Candida albicans is a pathogenic yeast that causes mucosal and systematic infections with high mortality. The absence of facile molecular genetics has been a major impediment to analysis of pathogenesis. The lack of meiosis coupled with the absence of plasmids makes genetic engineering cumbersome, especially for essential functions and gene families. We describe a C. albicans CRISPR system that overcomes many of the obstacles to genetic engineering in this organism. The high frequency with which CRISPR-induced mutations can be directed to target genes enables easy isolation of homozygous gene knockouts, even without selection. Moreover, the system permits the creation of strains with mutations in multiple genes, gene families, and genes that encode essential functions. This CRISPR system is also effective in a fresh clinical isolate of undetermined ploidy. Our method transforms the ability to manipulate the genome of Candida and provides a new window into the biology of this pathogen.

  1. Protozoan Infections

    Science.gov (United States)

    1989-01-01

    cooked meat of infected animals, especially sheep and pigs. Toxoplasma infects one-third to one-half of normal humans by age 40, but causes...Toxoplasma in the first trimester, 30-50 per cent deliver an obviously affected infant. Congenital infection is associated with hydrocephalus...chorioretinitis, hepatosplenomegaly, and rash. In survivors, mental retardation, deaf- ness, and cardiac malformations may be noted. Chorioretinitis may also

  2. Draft Permit & Supporting Documentation for the Northeast Gateway Energy Bridge Deepwater Port, Federal Waters of Massachusetts Bay (Modification to Existing Permit LNG Regasification Vessel/DWP Project)

    Science.gov (United States)

    List of draft permit & supporting documentation for the Northeast Gateway Energy Bridge Deepwater Port, Federal Waters of Massachusetts Bay (Modification to Existing Permit LNG Regasification Vessel/DWP Project).

  3. Draft Permit & Supporting Documentation for the Cape Wind Associates, LLC, Horseshoe Shoal, Nantucket Sound (Offshore Renewable Energy Project/OCS Air Permit)

    Science.gov (United States)

    List of draft permit & supporting documentation for the Cape Wind Associates, LLC, Horseshoe Shoal, Nantucket Sound (Offshore Renewable Energy Project/OCS Air Permit: Massachusetts Plan Approval including nonattainment NSR Appendix A requirements).

  4. Final Permit Documents for the Cape Wind Associates, LLC, Horseshoe Shoal, Nantucket Sound (Offshore Renewable Energy Project/OCS Air Permit)

    Science.gov (United States)

    List of finla permit documents for the Cape Wind Associates, LLC, Horseshoe Shoal, Nantucket Sound (Offshore Renewable Energy Project/OCS Air Permit: Massachusetts Plan Approval including nonattainment NSR Appendix A requirements).

  5. Air emission points for facilities in Iowa with operating permits for Title V of the Federal Clean Air Act_considered MAJOR permits

    Data.gov (United States)

    Iowa State University GIS Support and Research Facility — Air emission points for facilities in Iowa with operating permits for Title V of the Federal Clean Air Act, considered "major" permits. Also includes emission points...

  6. Hazardous Material Storage Facilities and Sites - WASTE_SOLID_ACTIVE_PERMITTED_IDEM_IN: Active Permitted Solid Waste Sites in Indiana (Indiana Department of Environmental Management, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — WASTE_SOLID_ACTIVE_PERMITTED_IDEM_IN is a point shapefile that contains active permitted solid waste site locations in Indiana, provided by personnel of Indiana...

  7. [Hand infections].

    Science.gov (United States)

    Schiele, Philippe; Le Nen, Dominique

    2013-11-01

    Superficial and deep hand infections are frequent in general medical practice. Clinical examination is a crucial step for an adapted provided care. Most of the time, surgery is the only way to heal infections. However, in some cases (like bites), empiric antibiotherapy is first indicated to limit infection. Staphyloccocus aureus as well as Group Beta Streptococcus are the most frequently pathogenes associated with hand infections. Methicillin resistant S. Aureus must always be considered in the diagnoses. Whatever treatment is provided, clinical assessement must be repeated within two days. An early adaquated treatment prevent functional complications and in some cases death of the patients.

  8. Rhinovirus Infections

    Science.gov (United States)

    ... Genitals and Urinary Tract Glands & Growth Head Neck & Nervous System Heart Infections Learning Disabilities Obesity Orthopedic Prevention Sexually Transmitted Skin Tobacco Treatments Injuries & ...

  9. Eye Infections

    Science.gov (United States)

    ... Genitals and Urinary Tract Glands & Growth Head Neck & Nervous System Heart Infections Learning Disabilities Obesity Orthopedic Prevention Sexually Transmitted Skin Tobacco Treatments Injuries & ...

  10. Campylobacter Infections

    Science.gov (United States)

    ... Genitals and Urinary Tract Glands & Growth Head Neck & Nervous System Heart Infections Learning Disabilities Obesity Orthopedic Prevention Sexually Transmitted Skin Tobacco Treatments Injuries & ...

  11. ALASKA OIL AND GAS EXPLORATION, DEVELOPMENT, AND PERMITTING PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    Richard McMahon; Robert Crandall; Chas Dense; Sean Weems

    2003-11-19

    This is the second technical report, covering the period from April 1, 2003 through September 30, 2003. This project brings together three parts of the oil exploration, development, and permitting process to form the foundation for a more fully integrated information technology infrastructure for the State of Alaska. The geo-technical component is a shared effort between the State Department of Administration and the US Department of Energy. The Alaska Oil and Gas Conservation Commission is rapidly converting high volumes of paper documents and geo-technical information to formats suitable for search and retrieval over the Internet. The permitting component is under the lead of the DNR Office of Project Management and Permitting. A web-based system will enable the public and other review participants to track permit status, submit and view comments, and obtain important project information on-line. By automating several functions of the current manual process, permit applications will be completed more quickly and accurately, and agencies will be able to complete reviews with fewer delays. Structural changes are taking place in terms of organization, statutory authority, and regulatory requirements. Geographic Information Systems are a central component to the organization of information, and the delivery of on-line services. Progress has been made to deploy the foundation system for the shared GIS based on open GIS protocols to the extent feasible. Alaska has nearly one-quarter of the nation's supply of crude oil, at least five billion barrels of proven reserves. The American Association of Petroleum Geologists report that the 1995 National Assessment identified the North Slope as having 7.4 billion barrels of technically recoverable oil and over 63 trillion cubic feet of natural gas. From these reserves, Alaska produces roughly one-fifth of the nation's daily crude oil production, or approximately one million barrels per day from over 1,800 active wells.

  12. 78 FR 18429 - Cost Recovery for Permit Processing, Administration, and Enforcement

    Science.gov (United States)

    2013-03-26

    ... 30 CFR Parts 701, 736, 737 et al. Cost Recovery for Permit Processing, Administration, and... 701, 736, 737, 738, and 750 RIN 1029-AC65 Cost Recovery for Permit Processing, Administration, and... fees to recover the actual costs for permit review and administration and permit enforcement...

  13. 36 CFR 242.6 - Licenses, permits, harvest tickets, tags, and reports.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Licenses, permits, harvest tickets, tags, and reports. 242.6 Section 242.6 Parks, Forests, and Public Property FOREST SERVICE... permits (Federal Subsistence Registration Permit or Federal Designated Harvester Permit) required...

  14. 50 CFR 697.24 - Exempted waters for Maine State American lobster permits.

    Science.gov (United States)

    2010-10-01

    ... lobster permits. 697.24 Section 697.24 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT... lobster permits. A person or vessel holding a valid permit or license issued by the State of Maine that lawfully permits that person to engage in commercial fishing for American lobster may, with the approval...

  15. 21 CFR 1210.26 - Permits for raw milk or cream.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Permits for raw milk or cream. 1210.26 Section... FEDERAL IMPORT MILK ACT Permit Control § 1210.26 Permits for raw milk or cream. Except as provided in § 1210.27, permits to ship or transport raw milk or cream into the United States will be granted...

  16. 21 CFR 1210.25 - Permits for pasteurized milk or cream.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Permits for pasteurized milk or cream. 1210.25... UNDER THE FEDERAL IMPORT MILK ACT Permit Control § 1210.25 Permits for pasteurized milk or cream. Permits to ship or transport pasteurized milk or cream into the United States will be granted only...

  17. 32 CFR 767.9 - Content of permit holder's final report.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Content of permit holder's final report. 767.9... JURISDICATION OF THE DEPARTMENT OF THE NAVY Permit Guidelines § 767.9 Content of permit holder's final report. The permit holder's final report shall include the following: (a) A site history and a...

  18. 50 CFR 22.25 - What are the requirements concerning permits to take golden eagle nests?

    Science.gov (United States)

    2010-10-01

    ... permits to take golden eagle nests? 22.25 Section 22.25 Wildlife and Fisheries UNITED STATES FISH AND..., BARTER, EXPORTATION, AND IMPORTATION OF WILDLIFE AND PLANTS (CONTINUED) EAGLE PERMITS Eagle Permits § 22.25 What are the requirements concerning permits to take golden eagle nests? The Director may,...

  19. 40 CFR 72.69 - Issuance and effective date of acid rain permits.

    Science.gov (United States)

    2010-07-01

    ...) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Federal Acid Rain Permit Issuance Procedures § 72.69 Issuance and effective date of acid rain permits. (a) After the close of the public comment period, the Administrator will issue or deny an Acid Rain permit. The Administrator will serve a copy of any Acid...

  20. 40 CFR 72.31 - Information requirements for Acid Rain permit applications.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Information requirements for Acid Rain... (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Permit Applications § 72.31 Information requirements for Acid Rain permit applications. A complete Acid Rain permit application shall include...

  1. 78 FR 77122 - Proposed Modification of a General NPDES Permit for Small Suction Dredging-Permit Number IDG-37-0000

    Science.gov (United States)

    2013-12-20

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed Modification of a General NPDES Permit for Small Suction Dredging--Permit Number IDG-37... Permit for placer mining operations in Idaho using small suction dredges (intake nozzle size of 5 inches...

  2. 78 FR 7428 - Clean Air Act Operating Permit Program; Petition for Objection to State Operating Permit for...

    Science.gov (United States)

    2013-02-01

    ... Control Technology Standard for Noranda's Industrial Boilers. On December 14, 2012, the Administrator...; certain stack tests show the NO X emissions exceed PSD thresholds, yet the Title V Permit fails to include applicable PSD requirements for NO X emissions; LDEQ failed to support its conclusion that emissions from...

  3. 77 FR 24200 - Clean Air Act Operating Permit Program; Petitions for Objection to State Operating Permits for...

    Science.gov (United States)

    2012-04-23

    ... catalytic reduction (``SCR'') control devices on pig iron emission units, even though these emission reductions are not federally enforceable; (3) Authorizing installation of SCR control devices by way of the modified pig iron title V permit violates PSD and the SIP because SCR will significantly increase...

  4. Staph Infections

    Science.gov (United States)

    ... ill or the area spreads and gets very red or and hot — it's a good idea to see a doctor. Wound infections generally show up 2 or more days after the injury or surgery. The signs of a wound infection (redness, pain, swelling, and warmth) are similar to those found in cellulitis. A ...

  5. Staphylococcal Infections

    Science.gov (United States)

    ... you should be familiar with include the following: Cellulitis is a bacterial skin infection that first affects the outer layers of the ... skin. Although other types of bacteria can cause cellulitis, Saureus ... may diagnose the infection by examining the area. The doctor may take ...

  6. Skin Infections

    Science.gov (United States)

    ... Old Feeding Your 8- to 12-Month-Old Feeding Your 1- to 2-Year-Old First Aid: Skin ... (bacterial infection of the deeper layers of the skin and tissues beneath) are typical childhood skin infections. The usual bacterial culprits in skin ...

  7. Market performance and environmental policy. Four tradeable permits schemes

    Energy Technology Data Exchange (ETDEWEB)

    Boom, J.T.; Duizendstraal, A.; De Jong, R.; Koster, J.M.M.; Nentjes, A.; Zhang, Z.X. [Department of Economics and Public Finance of the University of Groningen ECOF, Groningen (Netherlands); Van Buiren, K.; Van Es, G.A.; De Groot, A.W.M.; Velthuijsen, J.W. [Foundation for Economic Research of the University of Amsterdam SEO, Amsterdam (Netherlands); Van Duyse, P.; Heijnes, H. [Applied Environmental Economics TME, The Hague (Netherlands); Dijkgraaf, E.; Varkevisser, M. [Research Centre for Economic Policy OCfEB, Erasmus Universiteit, Rotterdam (Netherlands); Wiersma, D.

    1998-08-01

    Six feasible schemes of tradeable permits are presented and the cost savings arising from the application of such schemes instead of conventional policies have been calculated. In this background study four other schemes are discussed. The major reason for their separate presentation is twofold: there was insufficient statistical information available to calculate potential cost savings that are sufficiently reliable and further study is needed to determine the most appropriate design of the schemes. Only after the questions about cost savings and design have been answered it can be established whether indeed introduction of the schemes will improve environmental effectiveness and cost effectiveness of environmental policy. The schemes to be presented in the next sections are tradeable permits for winning sand, for mortar and cement, for noise control on industrial sites, for packaging materials and for heavy metals in waste water and sludge. 13 refs.

  8. Against Permitted Exploitation in Developing World Research Agreements.

    Science.gov (United States)

    Wenner, Danielle M

    2016-04-01

    This paper examines the moral force of exploitation in developing world research agreements. Taking for granted that some clinical research which is conducted in the developing world but funded by developed world sponsors is exploitative, it asks whether a third party would be morally justified in enforcing limits on research agreements in order to ensure more fair and less exploitative outcomes. This question is particularly relevant when such exploitative transactions are entered into voluntarily by all relevant parties, and both research sponsors and host communities benefit from the resulting agreements. I show that defenders of the claim that exploitation ought to be permitted rely on a mischaracterization of certain forms of interference as unjustly paternalistic and two dubious empirical assumptions about the results of regulation. The view I put forward is that by evaluating a system of constraints on international research agreements, rather than individual transaction-level interference, we can better assess the alternatives to permitting exploitative research agreements.

  9. Overview of prohibited and permitted plant regulatory listing systems

    Science.gov (United States)

    Westbrooks, Randy G.; Tasker, Alan V.

    2011-01-01

    Pest risk analysis is a process that evaluates the risks involved with a proposed species to help determine whether it should be permitted or denied entry into a country, and how the risks could be managed if it is imported. The prohibited listing approach was developed in the late 1800s and early 1900s in response to outbreaks of plant and animals pests such as foot and mouth disease of livestock, Mediterranean fruitfly (Ceratitis capitata Wiedemann), and Gypsy moth (Lymantria dispar L.). Under this approach, selected species of concern are evaluated to determine if they should be regulated for entry. Under the permitted listing approach that was first used on a national level in Australia in the 1990s, all species that are proposed for introduction are assessed to determine if they should be regulated.

  10. State Waste Discharge Permit application, 100-N Sewage Lagoon

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    As part of the Hanford Federal Facility Agreement and Consent Order negotiations (Ecology et al. 1994), the US Department of Energy, Richland Operations Office, the US Environmental Protection Agency, and the Washington State Department of Ecology agreed that liquid effluent discharges to the ground on the Hanford Site which affect groundwater or have the potential to affect groundwater would be subject to permitting under the structure of Chapter 173--216 (or 173--218 where applicable) of the Washington Administrative Code, the State Waste Discharge Permit Program. As a result of this decision, the Washington State Department of Ecology and the US Department of Energy, Richland Operations Office entered into Consent Order No. DE 91NM-177, (Ecology and DOE-RL 1991). This document constitutes the State Waste Discharge Permit application for the 100-N Sewage Lagoon. Since the influent to the sewer lagoon is domestic waste water, the State Waste Discharge Permit application for Public Owned Treatment Works Discharges to Land was used. Although the 100-N Sewage Lagoon is not a Public Owned Treatment Works, the Public Owned Treatment Works application is more applicable than the application for industrial waste water. The 100-N Sewage Lagoon serves the 100-N Area and other Hanford Site areas by receiving domestic waste from two sources. A network of sanitary sewer piping and lift stations transfers domestic waste water from the 100-N Area buildings directly to the 100-N Sewage Lagoon. Waste is also received by trucks that transport domestic waste pumped from on site septic tanks and holding tanks. Three ponds comprise the 100-N Sewage Lagoon treatment system. These include a lined aeration pond and stabilization pond, as well as an unlined infiltration pond. Both piped-in and trucked-in domestic waste is discharged directly into the aeration pond.

  11. State Waste Discharge Permit Application: Electric resistance tomography testing

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-01

    This permit application documentation is for a State Waste Discharge Permit issued in accordance with requirements of Washington Administrative Code 173-216. The activity being permitted is a technology test using electrical resistance tomography. The electrical resistance tomography technology was developed at Lawrence Livermore National Laboratory and has been used at other waste sites to track underground contamination plumes. The electrical resistance tomography technology measures soil electrical resistance between two electrodes. If a fluid contaminated with electrolytes is introduced into the soil, the soil resistance is expected to drop. By using an array of measurement electrodes in several boreholes, the areal extent of contamination can be estimated. At the Hanford Site, the purpose of the testing is to determine if the electrical resistance tomography technology can be used in the vicinity of large underground metal tanks without the metal tank interfering with the test. It is anticipated that the electrical resistance tomography technology will provide a method for accurately detecting leaks from the bottom of underground tanks, such as the Hanford Site single-shell tanks.

  12. Regulation of the climate in coupled convection-permitting simulations

    Science.gov (United States)

    Hohenegger, Cathy; Stevens, Bjorn

    2017-04-01

    The question of the regulation of the climate, in particular the existence of a stable climatic state and its basic characteristics, is investigated in this study. In contrast to previous studies, we use a convection-permitting simulation with an explicit representation of convection and of cloud cover. The grid spacing amounts to 3 km. The simulation is coupled to a slab ocean and is integrated in an idealized set-up of radiative convective equilibrium without rotation, without continent and with spatially uniform insolation. It is found that the system equilibrates at a sea surface temperature near the one of the present-day tropics. The equilibration results from the self-aggregation of convection that generates the dry and clear subtropics needed to radiate the excess heat from the system. When artificially preventing the self-aggregation, the existence of a runaway greenhouse cannot be ruled out. This is very different from what happens when performing a similar simulation at low resolution (T63) with a General Circulation Model (GCM) and parameterized cloud and convective processes. In that case, the atmosphere cools through an increase in planetary albedo arising from clouds. The total cloud radiative effect is 2.5 times larger than in the convection-permitting simulation. Perturbing the system by increasing the solar insolation also reveals a different behavior of the two simulations, with a larger warming in the convection-permitting simulation than in the GCM due to their distinct cloud feedbacks.

  13. ALASKA OIL AND GAS EXPLORATION, DEVELOPMENT, AND PERMITTING PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    Richard McMahon; Robert Crandall; Chas Dense; Sean Weems

    2003-08-04

    The objective of this project is to eliminate three closely inter-related barriers to oil production in Alaska through the use of a geographic information system (GIS) and other information technology strategies. These barriers involve identification of oil development potential from existing wells, planning projects to efficiently avoid conflicts with other interests, and gaining state approvals for exploration and development projects. Each barrier is the result of either current labor-intensive methods or poorly accessible information. This project brings together three parts of the oil exploration, development, and permitting process to form the foundation for a more fully integrated information technology infrastructure for the State of Alaska. This web-based system will enable the public and other review participants to track permit status, submit and view comments, and obtain important project information online. By automating several functions of the current manual process, permit applications will be completed more quickly and accurately, and agencies will be able to complete reviews with fewer delays. The application will include an on-line diagnostic Coastal Project Questionnaire to determine the suite of permits required for a specific project. The application will also automatically create distribution lists based on the location and type of project, populate document templates for project review start-ups, public notices and findings, allow submission of e-comments, and post project status information on the Internet. Alaska has nearly one-quarter of the nation's supply of crude oil, at least five billion barrels of proven reserves. The American Association of Petroleum Geologists report that the 1995 National Assessment identified the North Slope as having 7.4 billion barrels of technically recoverable oil and over 63 trillion cubic feet of natural gas. From these reserves, Alaska produces roughly one-fifth of the nation's daily crude oil

  14. infection i

    African Journals Online (AJOL)

    olayemitoyin

    Department of Veterinary Pathology, University of Ibadan, Ibadan, Nigeria. Summary: The ... Keywords: Pneumonia, West African Dwarf goats,Lung morphometry, Infection. ... high incidence of infectious diseases with pneumonia being an ...

  15. Neonatal Infections

    Science.gov (United States)

    ... as careful care and monitoring in the hospital. Listeriosis What is it? Infection with Listeria monocytogenes bacteria ... properly cleaned, pasteurized, or cooked may give someone listeriosis . Babies can acquire bacteria from their mothers if ...

  16. Campylobacter infection

    Science.gov (United States)

    ... in the small intestine from a bacteria called Campylobacter jejuni . It is a type of food poisoning. Causes ... testing for white blood cells Stool culture for Campylobacter jejuni Treatment The infection almost always goes away on ...

  17. Bacterial Infections

    Science.gov (United States)

    ... body will learn to resist them causing antibiotic resistance. Later, you could get or spread an infection that those antibiotics cannot cure. NIH: National Institute of Allergy and Infectious Diseases

  18. Chlamydia Infections

    Science.gov (United States)

    ... You can get chlamydia during oral, vaginal, or anal sex with someone who has the infection. A woman ... to prevent chlamydia is to not have vaginal, anal, or oral sex. Correct usage of latex condoms greatly reduces, but ...

  19. Salmonella Infection

    Science.gov (United States)

    ... children, use an oral rehydration solution, such as Pedialyte, unless your doctor advises otherwise. Salmonella infection can ... can use an oral rehydration solution, such as Pedialyte, unless your doctor advises otherwise. The U.S. Department ...

  20. Whipworm infection

    Science.gov (United States)

    ... don't have symptoms. Symptoms mainly occur in children, and range from mild to severe. A severe infection may cause: Bloody diarrhea Iron-deficiency anemia Fecal incontinence (during sleep) Rectal prolapse (the ...

  1. Biofilm Infections

    DEFF Research Database (Denmark)

    Bjarnsholt, Thomas; Jensen, Peter Østrup; Moser, Claus Ernst

    A still increasing interest and emphasis on the sessile bacterial lifestyle biofilms has been seen since it was realized that the vast majority of the total microbial biomass exists as biofilms. Aggregation of bacteria was first described by Leeuwenhoek in 1677, but only recently recognized...... as being important in chronic infection. In 1993 the American Society for Microbiology (ASM) recognized that the biofilm mode of growth was relevant to microbiology. This book covers both the evidence for biofilms in many chronic bacterial infections as well as the problems facing these infections...... such as diagnostics, pathogenesis, treatment regimes and in vitro and in vivo models for studying biofilms. This is the first scientific book on biofilm infections, chapters written by the world leading scientist and clinicians. The intended audience of this book is scientists, teachers at university level as well...

  2. Lung infection

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008050 The establishment of a rat model of chronic pulmonary infection of Pseudomonas aeruginosa. WANG Weifang(王炜芳), et al. Dept Respir, PLA General Hosp, Beijing 100853. Natl Med J China 2008;88(1):46-50. Objective To establish a rat model of chronic pulmonary infection by inoculating two different Pseudomonas aeruginosa embedded in minute seaweed algiante beads made by an ejection set with an acuminate hole to

  3. A Regional Multi-permit Market for Ecosystem Services

    Science.gov (United States)

    Bernknopf, R.; Amos, P.; Zhang, E.

    2014-12-01

    Regional cap and trade programs have been in operation since the 1970's to reduce environmental externalities (NOx and SOx emissions) and have been shown to be beneficial. Air quality and water quality limits are enforced through numerous Federal and State laws and regulations while local communities are seeking ways to protect regional green infrastructure and their ecosystems services. Why not combine them in a market approach to reduce many environmental externalities simultaneously? In a multi-permit market program reforestation (land offsets) as part of a nutrient or carbon sequestration trading program would provide a means to reduce agrochemical discharges into streams, rivers, and groundwater. Land conversions also improve the quality and quantity of other environmental externalities such as air pollution. Collocated nonmarket ecosystem services have societal benefits that can expand the crediting system into a multi-permit trading program. At a regional scale it is possible to combine regulation of water quality, air emissions and quality, and habitat conservation and restoration into one program. This research is about the economic feasibility of a Philadelphia regional multi-permit (cap and trade) program for ecosystem services. Instead of establishing individual markets for ecosystem services, the assumption of the spatial portfolio approach is that it is based on the interdependence of ecosystem functions so that market credits encompasses a range of ecosystem services. Using an existing example the components of the approach are described in terms of scenarios of land portfolios and the calculation of expected return on investment and risk. An experiment in the Schuylkill Watershed will be described for ecosystem services such as nutrients in water and populations of bird species along with Green House Gases. The Philadelphia regional market includes the urban - nonurban economic and environmental interactions and impacts.

  4. Ear infection - chronic

    Science.gov (United States)

    Middle ear infection - chronic; Otitis media - chronic; Chronic otitis media; Chronic ear infection ... up. When this happens, infection can occur. A chronic ear infection develops when fluid or an infection ...

  5. Ear Infections in Children

    Science.gov (United States)

    ... Home » Health Info » Hearing, Ear Infections, and Deafness Ear Infections in Children On this page: What is ... additional information about ear infections? What is an ear infection? An ear infection is an inflammation of ...

  6. Immunogenetics of leishmanial and mycobacterial infections: the Belem Family Study.

    OpenAIRE

    BLACKWELL, J.M.; Black, G F; Peacock, C S; Miller, E. N.; Sibthorpe, D; Gnananandha, D; J. J. Shaw; Silveira, F.; Lins-Lainson, Z.; Ramos, F; Collins, A.; Shaw, M A

    1997-01-01

    In the 1970s and 1980s, analysis of recombinant inbred, congenic and recombinant haplotype mouse strains permitted us to effectively 'scan' the murine genome for genes controlling resistance and susceptibility to leishmanial infections. Five major regions of the genome were implicated in the control of infections caused by different Leishmania species which, because they show conserved synteny with regions of the human genome, immediately provides candidate gene regions for human disease susc...

  7. Cerebral infections

    Energy Technology Data Exchange (ETDEWEB)

    Karampekios, Spyros [University of Crete, Department of Radiology, Heraklion, Crete (Greece); Hesselink, John [UCSD, Department of Radiology, San Diego, CA (United States)

    2005-03-01

    Despite the development of many effective antibiotic therapies and the general improvement in hygiene and health care systems all over the world, the incidence of central nervous system (CNS) infection has increased significantly in the past 15 years. This can be attributed primarily to the acquired immunodeficiency syndrome (AIDS) epidemic and its devastating effect on the immune system and secondarily to various immunosuppressive agents that are being used in aggressive cancer treatment and in organ transplantations. The brain particularly is protected from infection by the calvarium, meninges and blood brain barrier. However, different types of pathogens, including bacteria, viruses, fungi and parasites, can reach the brain hematogenously or, less likely, by direct extension from an adjacent infected focus. The early detection and specific diagnosis of infection are of great importance, since brain infections are potentially treatable diseases. Imaging studies play a crucial role in the diagnostic process, along with the history (exposure to infectious agents), host factors (open head trauma, CSF leak, sinusitis, otitis, immune status), physical examination and laboratory analysis of CSF. (orig.)

  8. Anchoretic Infection

    Directory of Open Access Journals (Sweden)

    S. Gokkulakrishnan

    2012-01-01

    Full Text Available Active and passive mouth opening exercises are a very common practice in oral and maxillofacial surgery especially for various conditions causing limited mouth opening like space infections, trauma, and ankylosis. But most of the practitioners do not follow basic principles while advocating these active mouth opening exercises and also take it for granted that it would benefit the patient in the long run. Because of this, the mouth opening physiotherapy by itself can at times lead to unwanted complications. We report a case wherein due to active physiotherapy, the patient had complications leading to persistent temporal space infection which required surgical intervention and hospitalization. This could have been because of hematoma formation during physiotherapy which got infected due to anchoretic infection of unknown etiology and resulted in temporal space infection. Hence, our conclusion is that whenever mouth opening exercises are initiated, it should be done gradually under good antibiotic coverage to avoid any untoward complications and for optimum results. According to the current English literature, such a complication has not been documented before.

  9. Bombardier Motor Company of America, Nonattainment Permit Applicability Determination

    Science.gov (United States)

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  10. PSD Permit Requirements and Applicability of New and Revised NAAQS

    Science.gov (United States)

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  11. Applicability of PSD Permitting Requirements, Wellcraft Marine Corporation, Sarasota, Florida

    Science.gov (United States)

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  12. Source Construction Prior to Issuance of PSD Permit

    Science.gov (United States)

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  13. Permitting Multi-Phase Construction Under PSD Regulations

    Science.gov (United States)

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  14. PSD and Title V Permitting Guidance for GHGs

    Science.gov (United States)

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  15. Guidance on Extension of Prevention of Significant Deterioration (PSD) Permits

    Science.gov (United States)

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  16. A.I. DuPont Institute PSD Permit

    Science.gov (United States)

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  17. USDA Forest Service, Rocky Mountain Region PSD Permit Completeness Determination

    Science.gov (United States)

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  18. 76 FR 77589 - Office of Hazardous Materials Safety; Notice of Application for Special Permits

    Science.gov (United States)

    2011-12-13

    .... Applicant affected permits thereof New Special Permits 15497-N U.S. Department of 49 CFR To authorize the... DBA Wilson 49 CFR 173.301(f).. To authorize the Supply Cumberland, transportation in MD. commerce...

  19. Environmental permits and approvals plan for high-level waste interim storage, Project W-464

    Energy Technology Data Exchange (ETDEWEB)

    Deffenbaugh, M.L.

    1998-05-28

    This report discusses the Permitting Plan regarding NEPA, SEPA, RCRA, and other regulatory standards and alternatives, for planning the environmental permitting of the Canister Storage Building, Project W-464.

  20. 77 FR 2311 - Endangered and Threatened Wildlife and Plants; Permit Applications

    Science.gov (United States)

    2012-01-17

    ... Fish and Wildlife Service Endangered and Threatened Wildlife and Plants; Permit Applications AGENCY... conduct certain activities with endangered species. With some exceptions, the Endangered Species Act (Act) prohibits activities with endangered and threatened species unless a Federal permit allows such...

  1. 78 FR 9687 - Prineville Energy Storage, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2013-02-11

    ... Energy Regulatory Commission Prineville Energy Storage, LLC; Notice of Preliminary Permit Application..., 2012, Prineville Energy Storage, LLC, filed an application for a preliminary permit, pursuant to...-hours. Applicant Contact: Mr. Matthew Shapiro, Chief Executive Officer, Prineville Energy Storage,...

  2. 78 FR 50405 - Amended Application for Presidential Permit; Northern Pass Transmission LLC

    Science.gov (United States)

    2013-08-19

    ... Application for Presidential Permit; Northern Pass Transmission LLC AGENCY: Office of Electricity Delivery and Energy Reliability, DOE. ACTION: Notice of Amended Application. SUMMARY: Northern Pass Transmission LLC (Northern Pass) has submitted an amended application for a Presidential permit to construct,...

  3. 76 FR 6459 - Mahoning Hydropower, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2011-02-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Mahoning Hydropower, LLC; Notice of Preliminary Permit Application Accepted.... On December 30, 2010, Mahoning Hydropower, LLC filed an application for a preliminary permit...

  4. 76 FR 7838 - Mahoning Hydropower, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2011-02-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Mahoning Hydropower, LLC; Notice of Preliminary Permit Application Accepted.... On December 30, 2010, Mahoning Hydropower, LLC filed an application for a preliminary permit...

  5. Environmental permits and approvals plan for high-level waste interim storage, Project W-464

    Energy Technology Data Exchange (ETDEWEB)

    Deffenbaugh, M.L.

    1998-05-28

    This report discusses the Permitting Plan regarding NEPA, SEPA, RCRA, and other regulatory standards and alternatives, for planning the environmental permitting of the Canister Storage Building, Project W-464.

  6. 78 FR 37563 - Endangered Species; Marine Mammals; Receipt of Applications for Permit

    Science.gov (United States)

    2013-06-21

    ...-04822B The following applicants each request a permit to import the sport- hunted trophy of two male.... Multiple Applicants The following applicants each request a permit to import the sport- hunted trophy...

  7. 36 CFR 222.3 - Issuance of grazing and livestock use permits.

    Science.gov (United States)

    2010-07-01

    ... event of drought or other emergency of National or Regional scope where such use would not result in... free permits for research purposes and administrative studies. (C) Paid or free permits to trail...

  8. 76 FR 21399 - Endangered and Threatened Wildlife and Plants; Permit Applications

    Science.gov (United States)

    2011-04-15

    .... ] Permit Applications Permit Application Number: TE38769A. Applicant: Sarah A. Bradley, Salem, MO. The... (Lycaeidesmelissasamuelis) on the Maas Preserve, Kent County, Michigan. Proposed activities are for enhancement of...

  9. Spinal infections

    Energy Technology Data Exchange (ETDEWEB)

    Tali, E. Turgut E-mail: turguttali@gazi.edu.tr

    2004-05-01

    Spinal infections can be thought of as a spectrum of disease comprising spondylitis, discitis, spondylodiscitis, pyogenic facet arthropathy, epidural infections, meningitis, polyradiculopathy and myelitis. Radiological evaluations have gained importance in the diagnosis, treatment planning, treatment and treatment monitoring of the spinal infections. Conventional radiographs are usually the initial imaging study. The sensitivity and specificity of the plain radiographs are very low. The sensitivity of CT is higher while it lacks of specificity. Conventional CT has played minor role for the diagnosis of early spondylitis and disc space infection and for follow-up, researches are going on the value of MDCT. MRI is as sensitive, specific and accurate as combined nuclear medicine studies and the method of choice for the spondylitis. Low signal areas of the vertebral body, loss of definition of the end plates and interruption of the cortical continuity, destruction of the cortical margins are typical on T1WI whereas high signal of affected areas of the vertebral body and disc is typical on T2WI. Contrast is mandatory and increases conspicuity, specificity, and observer confidence in the diagnosis and facilitates the treatment planning. Contrast enhancement is the earliest sign and pathognomonic in the acute inflammatory episode and even in the subtle infection then persists to a varying degree for several weeks or months. The outcome of the treatment is influenced by the type of infection and by the degree of neurologic compromise before treatment. There is an increasing move away from surgical intervention towards conservative therapy, percutaneous drainage of abscess or both. It is therefore critical to monitor treatment response, particularly in the immuno-deficient population.

  10. 78 FR 66683 - Fisheries in the Western Pacific; Special Coral Reef Ecosystem Fishing Permit

    Science.gov (United States)

    2013-11-06

    ... Coral Reef Ecosystem Fishing Permit AGENCY: National Marine Fisheries Service (NMFS), National Oceanic... assessment and finding of no significant impact for the issuance of a special coral reef ecosystem fishing permit. SUMMARY: NMFS issued a Special Coral Reef Ecosystem Fishing Permit that authorizes Kampachi Farms...

  11. 75 FR 53351 - Notice of Permit Application Received Under the Antarctic Conservation Act of 1978

    Science.gov (United States)

    2010-08-31

    ... Notice of Permit Application Received Under the Antarctic Conservation Act of 1978 AGENCY: National Science Foundation. ACTION: Notice of permit applications received under the Antarctic Conservation Act... permit application for operation of a camp at Patriot Hills, Heritage Range, southern Ellsworth...

  12. 75 FR 78973 - Proposed Information Collection; Comment Request; Special Subsistence Permits and Harvest Logs...

    Science.gov (United States)

    2010-12-17

    ... Subsistence Permits and Harvest Logs for Pacific Halibut in Waters Off Alaska AGENCY: National Oceanic and... Response: Permit applications, 10 minutes; Community harvest log, 30 minutes; Ceremonial or educational harvest log, 30 minutes; Appeal for permit denial, 4 hours. Estimated Total Annual Burden Hours:...

  13. 14 CFR 437.17 - Rights not conferred by an experimental permit.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Rights not conferred by an experimental... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING EXPERIMENTAL PERMITS General Information § 437.17 Rights not conferred by an experimental permit. Issuance of an experimental permit does not relieve...

  14. 40 CFR 74.10 - Roles-EPA and permitting authority.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Roles-EPA and permitting authority. 74.10 Section 74.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE OPT-INS Permitting Procedures § 74.10 Roles—EPA and permitting authority. (a...

  15. 50 CFR 216.41 - Permits for scientific research and enhancement.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Permits for scientific research and... AND IMPORTING OF MARINE MAMMALS Special Exceptions § 216.41 Permits for scientific research and enhancement. In addition to the requirements under §§ 216.33 through 216.38, permits for scientific research...

  16. 30 CFR 922.783 - Underground mining permit applications-minimum requirements for information on environmental...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Underground mining permit applications-minimum... MINING OPERATIONS WITHIN EACH STATE MICHIGAN § 922.783 Underground mining permit applications—minimum requirements for information on environmental resources. Part 783 of this chapter, Underground Mining Permit...

  17. 30 CFR 937.783 - Underground mining permit applications-minimum requirements for information on environmental...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Underground mining permit applications-minimum... MINING OPERATIONS WITHIN EACH STATE OREGON § 937.783 Underground mining permit applications—minimum requirements for information on environmental resources. Part 783 of this chapter, Underground Mining Permit...

  18. 30 CFR 939.783 - Underground mining permit applications-minimum requirements for information on environmental...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Underground mining permit applications-minimum... MINING OPERATIONS WITHIN EACH STATE RHODE ISLAND § 939.783 Underground mining permit applications—minimum requirements for information on environmental resources. Part 783 of this chapter, Underground Mining Permit...

  19. 30 CFR 912.783 - Underground mining permit applications-minimum requirements for information on environmental...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Underground mining permit applications-minimum... MINING OPERATIONS WITHIN EACH STATE IDAHO § 912.783 Underground mining permit applications—minimum requirements for information on environmental resources. Part 783 of this chapter, Underground Mining Permit...

  20. 30 CFR 910.783 - Underground mining permit applications-minimum requirements for information on environmental...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Underground mining permit applications-minimum... MINING OPERATIONS WITHIN EACH STATE GEORGIA § 910.783 Underground mining permit applications—minimum requirements for information on environmental resources. Part 783 of this chapter, Underground Mining Permit...