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Sample records for cd program applied

  1. Applied Energy Program

    Science.gov (United States)

    Science Programs Applied Energy Programs Civilian Nuclear Energy Programs Laboratory Directed Research » Applied Energy Program Applied Energy Program Los Alamos is using its world-class scientific capabilities to enhance national energy security by developing energy sources with limited environmental impact

  2. Implementing an Applied Science Program

    Science.gov (United States)

    Rickman, Doug; Presson, Joan

    2007-01-01

    The work implied in the NASA Applied Science Program requires a delicate balancing act for the those doing it. At the implementation level there are multiple tensions intrinsic to the program. For example each application of an existing product to a decision support process requires deep knowledge about the data and deep knowledge about the decision making process. It is highly probable no one person has this range of knowledge. Otherwise the decision making process would already be using the data. Therefore, a team is required. But building a team usually requires time, especially across agencies. Yet the program mandates efforts of relatively short duration. Further, those who know the data are scientists, which makes them essential to the program. But scientists are evaluated on their publication record. Anything which diverts a scientist from the research for his next publication is an anathema to him and potential death to their career. Trying to get another agency to use NASA data does not strike most scientists as material inherently suitable for publication. Also, NASA wishes to rapidly implement often substantial changes to another agency's process. For many reasons, such as budget and program constraints, speed is important. But the owner of a decision making process is tightly constrained, usually by law, regulation, organization and custom. Changes when made are slow, cautious, even hesitant, and always done according a process specific to the situation. To manage this work MSFC must balance these and other tensions. Some things we have relatively little control over, such as budget. These we try to handle by structural techniques. For example by insisting all of our people work on multiple projects simultaneously we inherently have diversification of funding for all of our people. In many cases we explicitly use some elements of tension to be productive. For example the need for the scientists to constantly publish is motivation to keep tasks short and

  3. Applied Integer Programming Modeling and Solution

    CERN Document Server

    Chen, Der-San; Dang, Yu

    2011-01-01

    An accessible treatment of the modeling and solution of integer programming problems, featuring modern applications and software In order to fully comprehend the algorithms associated with integer programming, it is important to understand not only how algorithms work, but also why they work. Applied Integer Programming features a unique emphasis on this point, focusing on problem modeling and solution using commercial software. Taking an application-oriented approach, this book addresses the art and science of mathematical modeling related to the mixed integer programming (MIP) framework and

  4. Applied Information Systems Research Program Workshop

    Science.gov (United States)

    1991-01-01

    The first Applied Information Systems Research Program (AISRP) Workshop provided the impetus for several groups involved in information systems to review current activities. The objectives of the workshop included: (1) to provide an open forum for interaction and discussion of information systems; (2) to promote understanding by initiating a dialogue with the intended benefactors of the program, the scientific user community, and discuss options for improving their support; (3) create an advocacy in having science users and investigators of the program meet together and establish the basis for direction and growth; and (4) support the future of the program by building collaborations and interaction to encourage an investigator working group approach for conducting the program.

  5. Interactive computer programs for applied nutrition education.

    Science.gov (United States)

    Wise, A

    1985-12-01

    DIET2 and DIET3 are programs written for a Dec2050 computer and intended for teaching applied nutrition to students of nutrition, dietetics, home economics, and hotel and institutional administration. DIET2 combines all the facilities of the separate dietary programs already available at Robert Gordon's Institute of Technology into a single package, and extends these to give students a large amount of relevant information about the nutritional balance of foods (including DHSS and NACNE recommendations) prior to choosing them for meals. Students are also helped by the inclusion of typical portion weights. They are presented with an analysis of nutrients and their balance in the menu created, with an easy mechanism for ammendation of the menu and addition of foods which provide the nutrients that are lacking. At any stage the computer can give the proportion of total nutrient provided by each meal. DIET3 is a relatively simple program that displays the nutritional profile of foods and diets semigraphically.

  6. Fusion programs in Applied Plasma Physics

    International Nuclear Information System (INIS)

    1992-07-01

    The Applied Plasma Physics (APP) program at General Atomics (GA) described here includes four major elements: (a) Applied Plasma Physics Theory Program, (b) Alpha Particle Diagnostic, (c) Edge and Current Density Diagnostic, and (d) Fusion User Service Center (USC). The objective of the APP theoretical plasma physics research at GA is to support the DIII-D and other tokamak experiments and to significantly advance our ability to design a commercially-attractive fusion reactor. We categorize our efforts in three areas: magnetohydrodynamic (MHD) equilibria and stability; plasma transport with emphasis on H-mode, divertor, and boundary physics; and radio frequency (rf). The objective of the APP alpha particle diagnostic is to develop diagnostics of fast confined alpha particles using the interactions with the ablation cloud surrounding injected pellets and to develop diagnostic systems for reacting and ignited plasmas. The objective of the APP edge and current density diagnostic is to first develop a lithium beam diagnostic system for edge fluctuation studies on the Texas Experimental Tokamak (TEXT). The objective of the Fusion USC is to continue to provide maintenance and programming support to computer users in the GA fusion community. The detailed progress of each separate program covered in this report period is described in the following sections

  7. Fusion programs in applied plasma physics

    International Nuclear Information System (INIS)

    1993-07-01

    This report summarizes the progress made in theoretical and experimental research funded by US Department of Energy Grant No. DE-FG03-92ER54150, during the period July 11, 1992 through May 31, 1993. Four main tasks are reported: applied plasma physics theory, alpha particle diagnostic, edge and current density diagnostic, and plasma rotation drive. The report also discusses the research plans for the theory and experimental programs for the next grant year. Reports and publications supported by the grant during this period are listed in the final section

  8. Study on rice absorption and distribution of Cd in applying Zn fertilizer with 65Zn, 115Cdm tracing technique

    International Nuclear Information System (INIS)

    Tang Nianxin; Shen Jinxiong

    1994-01-01

    Results of study by using 65 Zn and 115 Cd m tracers show that, along with the increase of the amount of Cd in applying Zn fertilizer to soil, rice has the phenomena of growth retard and tiller delay in the earlier growing stage. The inhibiting phenomenon is lightened along with the progress of rice growth. Very small quantity of Cd might be helpful to the growth of rice. It would cause serious inhibition to rice growth when the amount of Cd reaches to a definite limitation (64 x 10 -6 ). The distribution of Cd in a rice plant follows the following order in content: root>stem and leaves>brown rice>ear stalk>rice shell. Cd is mainly accumulated in rice root, taking 90% of the total amount of Cd contained in whole rice plant. The amount of Cd absorbed by rice increases with the amount of Cd applied to soil, though the total absorption extremely low, for example, only about 0.1% of the applied amount could be absorbed by two crops of rice, most of the applied Cd still retains in soil. Less and less Zn could be absorbed and utilized by rice along with the increase of the amount of the applied Cd. Application of Mn fertilizer affects negatively the absorption of Cd by rice, especially in brown rice

  9. NASA's Applied Sciences: Natural Disasters Program

    Science.gov (United States)

    Kessler, Jason L.

    2010-01-01

    Fully utilize current and near-term airborne and spaceborne assets and capabilities. NASA spaceborne instruments are for research but can be applied to natural disaster response as appropriate. NASA airborne instruments can be targeted specifically for disaster response. Could impact research programs. Better flow of information improves disaster response. Catalog capability, product, applicable disaster, points of contact. Ownership needs to come from the highest level of NASA - unpredictable and irregular nature of disasters requires contingency funding for disaster response. Build-in transfer of applicable natural disaster research capabilities to operational functionality at other agencies (e.g., USFS, NOAA, FEMA...) at the outset, whenever possible. For the Decadal Survey Missions, opportunities exist to identify needs and requirements early in the mission design process. Need to understand additional needs and commitments for meeting the needs of the disaster community. Opportunity to maximize disaster response and mitigation from the Decadal Survey Missions. Additional needs or capabilities may require agency contributions.

  10. Fusion programs in applied plasma physics

    International Nuclear Information System (INIS)

    1992-02-01

    The objectives of the theoretical science program are: To support the interpretation of present experiments and predict the outcome of future planned experiments; to improve on existing models and codes and validate against experimental results; and to conduct theoretical physics development of advanced concepts with applications for DIII-D and future devices. Major accomplishments in FY91 include the corroboration between theory and experiment on MHD behavior in the second stable regime of operation on DIII-D, and the frequency and mode structure of toroidal Alfven eigenmodes in high beta, shaped plasmas. We have made significant advances in the development of the gyro-Landau fluid approach to turbulence simulation which more accurately models kinetic drive and damping mechanisms. Several theoretical models to explain the bifurcation phenomenon in L- to H-mode transition were proposed providing the theoretical basis for future experimental verification. The capabilities of new rf codes have been upgraded in response to the expanding needs of the rf experiments. Codes are being employed to plan for a fully non-inductive current drive experiment in a high beta, enhanced confinement regime. GA's experimental effort in Applied Physics encompasses two advanced diagnostics essential for the operation of future fusion experiments: Alpha particle diagnostic, and current and density profile diagnostics. This paper discusses research in all these topics

  11. Applying QA to nuclear-development programs

    International Nuclear Information System (INIS)

    Caplinger, W.H.

    1981-12-01

    The application of quality assurance (QA) principles to developmental programs is usually accomplished by tailoring or selecting appropriate requirements from large QA systems. Developmental work at Westinghouse Hanford Company (WHC) covers the complete range from basic research to in-core reactor tests. Desired requirements are selected from the 18 criteria in ANSI/ASME NQA Standard 1 by the cognizant program engineer in conjunction with the quality engineer. These referenced criteria assure that QA for the program is planned, implemented, and maintained. In addition, the WHC QA Manual provides four categories or levels of QA that are assigned to programs or components within the program. These categories are based on safety, reliability, and consequences of failure to provide a cost effective program

  12. Collaborative applied research programs at AITF

    Energy Technology Data Exchange (ETDEWEB)

    Chow, Ross [Alberta Innovates Technology Futures (Canada)

    2011-07-01

    Alberta Innovates Technology Futures (AITF) is a 600 employee company created in 2010 and owned by the Alberta government; offices are located in Edmonton, Devon, Vegreville and Calgary. The purpose of this document is to present the services provided by AITF. The company provides technical support and advisory services as well as commercialization support, they provide the link between the concept stage and the commercialization stage. AITF proposes collaborative programs which can be consortia made up of a series of projects on general industry issues or joint industry projects which focus on a specific issue. During this presentation, a joint industry project, the fuels and lubricants exchange program, was presented along with several consortia such as the carbonate research program, the materials and reliability in oil sands program, and the AACI program. This presentation highlighted the work carried out by AITF to meet the needs of their clients.

  13. Applied programs at Brookhaven National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    1991-09-01

    This document overviews the areas of current research at Brookhaven National Laboratory. Technology transfer and the user facilities are discussed. Current topics are presented in the areas of applied physics, chemical science, material science, energy efficiency and conservation, environmental health and mathematics, biosystems and process science, oceanography, and nuclear energy. (GHH)

  14. Quality assurance applied to an environmental surveillance program

    International Nuclear Information System (INIS)

    Oakes, T.W.; Shank, K.E.; Eldridge, J.S.

    1977-01-01

    A discussion of a quality assurance program applied to environmental surveillance activities is presented. This includes the philosophy and concepts of quality assurance, along with a detailed assessment of the sources of uncertainty in a monitoring program. The role management must play for a successful program is also discussed, and the quality assurance program implemented at Oak Ridge National Laboratory is presented

  15. Enhanced performance of CdS/CdTe thin-film devices through temperature profiling techniques applied to close-spaced sublimation deposition

    Energy Technology Data Exchange (ETDEWEB)

    Xiaonan Li; Sheldon, P.; Moutinho, H.; Matson, R. [National Renewable Energy Lab., Golden, CO (United States)

    1996-05-01

    The authors describe a methodology developed and applied to the close-spaced sublimation technique for thin-film CdTe deposition. The developed temperature profiles consisted of three discrete temperature segments, which the authors called the nucleation, plugging, and annealing temperatures. They have demonstrated that these temperature profiles can be used to grow large-grain material, plug pinholes, and improve CdS/CdTe photovoltaic device performance by about 15%. The improved material and device properties have been obtained while maintaining deposition temperatures compatible with commercially available substrates. This temperature profiling technique can be easily applied to a manufacturing environment by adjusting the temperature as a function of substrate position instead of time.

  16. Applying machine learning to predict patient-specific current CD 4 ...

    African Journals Online (AJOL)

    This work shows the application of machine learning to predict current CD4 cell count of an HIV-positive patient using genome sequences, viral load and time. A regression model predicting actual CD4 cell counts and a classification model predicting if a patient's CD4 cell count is less than 200 was built using a support ...

  17. 34 CFR 400.3 - What other regulations apply to the Vocational and Applied Technology Education Programs?

    Science.gov (United States)

    2010-07-01

    ... Applied Technology Education Programs? 400.3 Section 400.3 Education Regulations of the Offices of the... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAMS-GENERAL PROVISIONS § 400.3 What other regulations apply to the Vocational and Applied Technology Education Programs? The following regulations apply to the...

  18. 1984 Review of the Applied Plasma Physics Program

    International Nuclear Information System (INIS)

    1984-09-01

    This report describes the present and planned programs of the Division of Applied Plasma Physics (APP), Office of Fusion Energy. The major activities of the division include fusion theory, experimental plasma research, advanced fusion concepts, and the magnetic fusion energy computer network. The planned APP program is consistent with the recently issued Comprehensive Program Management Plan for Magnetic Fusion Energy, which describes the overall objectives and strategy for the development of fusion energy

  19. Lessons from NASA Applied Sciences Program: Success Factors in Applying Earth Science in Decision Making

    Science.gov (United States)

    Friedl, L. A.; Cox, L.

    2008-12-01

    The NASA Applied Sciences Program collaborates with organizations to discover and demonstrate applications of NASA Earth science research and technology to decision making. The desired outcome is for public and private organizations to use NASA Earth science products in innovative applications for sustained, operational uses to enhance their decisions. In addition, the program facilitates the end-user feedback to Earth science to improve products and demands for research. The Program thus serves as a bridge between Earth science research and technology and the applied organizations and end-users with management, policy, and business responsibilities. Since 2002, the Applied Sciences Program has sponsored over 115 applications-oriented projects to apply Earth observations and model products to decision making activities. Projects have spanned numerous topics - agriculture, air quality, water resources, disasters, public health, aviation, etc. The projects have involved government agencies, private companies, universities, non-governmental organizations, and foreign entities in multiple types of teaming arrangements. The paper will examine this set of applications projects and present specific examples of successful use of Earth science in decision making. The paper will discuss scientific, organizational, and management factors that contribute to or impede the integration of the Earth science research in policy and management. The paper will also present new methods the Applied Sciences Program plans to implement to improve linkages between science and end users.

  20. What Influences Medical Students to Apply or Not to Apply for Dermatology Residency Programs?

    Science.gov (United States)

    Matheny, Pamela M.

    2016-01-01

    Medical students apply for dermatology residency program acceptance and, after completing training, become eligible to take the American Board of Dermatology examination. Some recent dermatologist practice trends concern dermatology leaders in academia. Changing the workforce trends may begin with changing the workforce. Academic dermatology…

  1. Applying machine learning to predict patient-specific current CD4 ...

    African Journals Online (AJOL)

    Apple apple

    This work shows the application of machine learning to predict current CD4 cell count of an HIV- .... Pre-processing ... remaining data elements of the PR and RT datasets. ... technique based on the structure of the human brain's neuron.

  2. Applied Information Systems Research Program (AISRP) Workshop 3 meeting proceedings

    Science.gov (United States)

    1993-01-01

    The third Workshop of the Applied Laboratory Systems Research Program (AISRP) met at the Univeristy of Colorado's Laboratory for Atmospheric and Space Physics in August of 1993. The presentations were organized into four sessions: Artificial Intelligence Techniques; Scientific Visualization; Data Management and Archiving; and Research and Technology.

  3. Open Photoacoustic Cell Configuration Applied to the Thermal Characterization of Liquid CdS Nanocomposites

    Science.gov (United States)

    Faraji, Nastaran; Mahmood Mat Yunus, W.; Kharazmi, Alireza; Saion, Elias; Behzad, Kasra

    2014-01-01

    CdS nanofluids were prepared by the gamma-radiation method at different radiation doses. The samples were characterized by UV-Vis spectroscopy and transmission electron microscopy. The open cell photoacoustic technique was used to measure the thermal effusivity of the CdS nanocomposites. In this technique a He-Ne laser was used as the excitation source and was operated at 632.8 nm with an output power of 70 mW. The precision and accuracy of this technique were initially established by measuring the thermal effusivity of distilled water and ethylene glycol. The thermal-effusivity values of these two samples were found to be close to the values reported in the literature. The thermal effusivity of CdS nanofluids decreased from (0.453 to 0.268) with increased dosage of gamma radiation.

  4. Applied Science Division annual report, Environmental Research Program FY 1983

    International Nuclear Information System (INIS)

    Cairns, E.J.; Novakov, T.

    1984-05-01

    The primary concern of the Environmental Research Program is the understanding of pollutant formation, transport, and transformation and the impacts of pollutants on the environment. These impacts include global, regional, and local effects on the atmosphere and hydrosphere, and on certain aspects of human health. This multidisciplinary research program includes fundamental and applied research in physics, chemistry, engineering, and biology, as well as research on the development of advanced methods of measurement and analysis. During FY 1983, research concentrated on atmospheric physics and chemistry, applied physics and laser spectroscopy, combustion theory and phenomena, environmental effects of oil shale processing, freshwater ecology and acid precipitation, trace element analysis for the investigation of present and historical environmental impacts, and a continuing survey of instrumentation for environmental monitoring

  5. How to apply to a summer undergraduate research program

    OpenAIRE

    Jafree, D. J.; Koshy, K.

    2017-01-01

    Want to get more experience in research, but find it difficult as an undergraduate? A summer research project may be the answer and there are many ways to organize this. Various universities around the world offer summer undergraduate research programs. These tend to be very competitive; hundreds, even thousands of students can apply for only a handful of positions. However, with some proactivity and strong planning, diligent undergraduate students can get accepted onto these prestigious prog...

  6. Genetic programming applied to RFI mitigation in radio astronomy

    Science.gov (United States)

    Staats, K.

    2016-12-01

    Genetic Programming is a type of machine learning that employs a stochastic search of a solutions space, genetic operators, a fitness function, and multiple generations of evolved programs to resolve a user-defined task, such as the classification of data. At the time of this research, the application of machine learning to radio astronomy was relatively new, with a limited number of publications on the subject. Genetic Programming had never been applied, and as such, was a novel approach to this challenging arena. Foundational to this body of research, the application Karoo GP was developed in the programming language Python following the fundamentals of tree-based Genetic Programming described in "A Field Guide to Genetic Programming" by Poli, et al. Karoo GP was tasked with the classification of data points as signal or radio frequency interference (RFI) generated by instruments and machinery which makes challenging astronomers' ability to discern the desired targets. The training data was derived from the output of an observation run of the KAT-7 radio telescope array built by the South African Square Kilometre Array (SKA-SA). Karoo GP, kNN, and SVM were comparatively employed, the outcome of which provided noteworthy correlations between input parameters, the complexity of the evolved hypotheses, and performance of raw data versus engineered features. This dissertation includes description of novel approaches to GP, such as upper and lower limits to the size of syntax trees, an auto-scaling multiclass classifier, and a Numpy array element manager. In addition to the research conducted at the SKA-SA, it is described how Karoo GP was applied to fine-tuning parameters of a weather prediction model at the South African Astronomical Observatory (SAAO), to glitch classification at the Laser Interferometer Gravitational-wave Observatory (LIGO), and to astro-particle physics at The Ohio State University.

  7. CO-CD base management model of Universitas Terbuka community service program

    Science.gov (United States)

    Kridasakti, S. W.; Sudirah; Siregar, H.

    2018-03-01

    These studies were to respond whether the UT social-aid management had been executed under CO-CD principles (Ife J. 1995) and what CO-CD base community service management model can be built. The goals of these evaluational studies were UT social-aid managerial performance profile (2011-2013) and CO-CD management model development. The methods used were Survey and FGD. For data collection were involving the UT officers, the counterparts, and the documents. The analysis used combination between the Performance Analysis (Irawan P., 2003) and the CIPP (Stuffelbeam, D, L., & Shinkfield, A, J., 1985). The findings showed that the quantitative targeting in program completion was credible in achievement (85%). However, the “qulitative targeting” of the management goals was indicating far from a good-stage (≤5.0_Interval-Force: 1-10 Scale). The “Gap” was due to the absent of socialization_needs-analysis_maintenance_release factors on the UT social-service grand-policy. The trial of CO-CD Base Management Model had been imposed to the community that turned out to be very effective to self-help, and the ensuing SOP had been successfully defined. Conclusion, ‘CO-CD Principles’ were not designed in UT community service programs management. However, if efficiency and effectivity likely to be achieved, the SOP of ‘CO-CD Base Management Model has to be adopted.

  8. NASA'S Water Resources Element Within the Applied Sciences Program

    Science.gov (United States)

    Toll, David; Doorn, Bradley; Engman, Edwin

    2010-01-01

    The NASA Applied Sciences Program works within NASA Earth sciences to leverage investment of satellite and information systems to increase the benefits to society through the widest practical use of NASA research results. Such observations provide a huge volume of valuable data in both near-real-time and extended back nearly 50 years about the Earth's land surface conditions such as land cover type, vegetation type and health, precipitation, snow, soil moisture, and water levels and radiation. Observations of this type combined with models and analysis enable satellite-based assessment of numerous water resources management activities. The primary goal of the Earth Science Applied Science Program is to improve future and current operational systems by infusing them with scientific knowledge of the Earth system gained through space-based observation, model results, and development and deployment of enabling technologies, systems, and capabilities. Water resources is one of eight elements in the Applied Sciences Program and it addresses concerns and decision making related to water quantity and water quality. With increasing population pressure and water usage coupled with climate variability and change, water issues are being reported by numerous groups as the most critical environmental problems facing us in the 21st century. Competitive uses and the prevalence of river basins and aquifers that extend across boundaries engender political tensions between communities, stakeholders and countries. Mitigating these conflicts and meeting water demands requires using existing resources more efficiently. The potential crises and conflicts arise when water is competed among multiple uses. For example, urban areas, environmental and recreational uses, agriculture, and energy production compete for scarce resources, not only in the Western U.S. but throughout much of the U.S. but also in many parts of the world. In addition to water availability issues, water quality related

  9. Reactive glia promote development of CD103+ CD69+ CD8+ T-cells through programmed cell death-ligand 1 (PD-L1).

    Science.gov (United States)

    Prasad, Sujata; Hu, Shuxian; Sheng, Wen S; Chauhan, Priyanka; Lokensgard, James R

    2018-06-01

    Previous work from our laboratory has demonstrated in vivo persistence of CD103 + CD69 + brain resident memory CD8 + T-cells (bT RM ) following viral infection, and that the PD-1: PD-L1 pathway promotes development of these T RM cells within the brain. Although glial cells express low basal levels of PD-L1, its expression is upregulated upon IFN-γ-treatment, and they have been shown to modulate antiviral T-cell effector responses through the PD-1: PD-L1 pathway. We performed flow cytometric analysis of cells from co-cultures of mixed glia and CD8 + T-cells obtained from wild type mice to investigate the role of glial cells in the development of bT RM . In this study, we show that interactions between reactive glia and anti-CD3 Ab-stimulated CD8 + T-cells promote development of CD103 + CD69 + CD8 + T-cells through engagement of the PD-1: PD-L1 pathway. These studies used co-cultures of primary murine glial cells obtained from WT animals along with CD8 + T-cells obtained from either WT or PD-1 KO mice. We found that αCD3 Ab-stimulated CD8 + T-cells from WT animals increased expression of CD103 and CD69 when co-cultured with primary murine glial cells. In contrast, significantly reduced expression of CD103 and CD69 was observed using CD8 + T-cells from PD-1 KO mice. We also observed that reactive glia promoted high levels of CD127, a marker of memory precursor effector cells (MPEC), on CD69 + CD8 + T-cells, which promotes development of T RM cells. Interestingly, results obtained using T-cells from PD-1 KO animals showed significantly reduced expression of CD127 on CD69 + CD8 + cells. Additionally, blocking of glial PD-L1 resulted in decreased expression of CD103, along with reduced CD127 on CD69 + CD8 + T-cells. Taken together, these results demonstrate a role for activated glia in promoting development of bT RM through the PD-1: PD-L1 pathway. © 2018 The Authors. Immunity, Inflammation and Disease Published by John Wiley & Sons Ltd.

  10. Environmental impacts of precision feeding programs applied in pig production.

    Science.gov (United States)

    Andretta, I; Hauschild, L; Kipper, M; Pires, P G S; Pomar, C

    2017-12-04

    This study was undertaken to evaluate the effect that switching from conventional to precision feeding systems during the growing-finishing phase would have on the potential environmental impact of Brazilian pig production. Standard life-cycle assessment procedures were used, with a cradle-to-farm gate boundary. The inputs and outputs of each interface of the life cycle (production of feed ingredients, processing in the feed industry, transportation and animal rearing) were organized in a model. Grain production was independently characterized in the Central-West and South regions of Brazil, whereas the pigs were raised in the South region. Three feeding programs were applied for growing-finishing pigs: conventional phase feeding by group (CON); precision daily feeding by group (PFG) (whole herd fed the same daily adjusted diet); and precision daily feeding by individual (PFI) (diets adjusted daily to match individual nutrient requirements). Raising pigs (1 t pig BW at farm gate) in South Brazil under the CON feeding program using grain cultivated in the same region led to emissions of 1840 kg of CO2-eq, 13.1 kg of PO4-eq and 32.2 kg of SO2-eq. Simulations using grain from the Central-West region showed a greater climate change impact. Compared with the previous scenario, a 17% increase in climate change impact was found when simulating with soybeans produced in Central-West Brazil, whereas a 28% increase was observed when simulating with corn and soybeans from Central-West Brazil. Compared with the CON feeding program, the PFG and PFI programs reduced the potential environmental impact. Applying the PFG program mitigated the potential climate change impact and eutrophication by up to 4%, and acidification impact by up to 3% compared with the CON program. Making a further adjustment by feeding pigs according to their individual nutrient requirements mitigated the potential climate change impact by up to 6% and the potential eutrophication and acidification impact

  11. Applied Information Systems Research Program (AISRP). Workshop 2: Meeting Proceedings

    Science.gov (United States)

    1992-01-01

    The Earth and space science participants were able to see where the current research can be applied in their disciplines and computer science participants could see potential areas for future application of computer and information systems research. The Earth and Space Science research proposals for the High Performance Computing and Communications (HPCC) program were under evaluation. Therefore, this effort was not discussed at the AISRP Workshop. OSSA's other high priority area in computer science is scientific visualization, with the entire second day of the workshop devoted to it.

  12. Swarm, genetic and evolutionary programming algorithms applied to multiuser detection

    Directory of Open Access Journals (Sweden)

    Paul Jean Etienne Jeszensky

    2005-02-01

    Full Text Available In this paper, the particles swarm optimization technique, recently published in the literature, and applied to Direct Sequence/Code Division Multiple Access systems (DS/CDMA with multiuser detection (MuD is analyzed, evaluated and compared. The Swarm algorithm efficiency when applied to the DS-CDMA multiuser detection (Swarm-MuD is compared through the tradeoff performance versus computational complexity, being the complexity expressed in terms of the number of necessary operations in order to reach the performance obtained through the optimum detector or the Maximum Likelihood detector (ML. The comparison is accomplished among the genetic algorithm, evolutionary programming with cloning and Swarm algorithm under the same simulation basis. Additionally, it is proposed an heuristics-MuD complexity analysis through the number of computational operations. Finally, an analysis is carried out for the input parameters of the Swarm algorithm in the attempt to find the optimum parameters (or almost-optimum for the algorithm applied to the MuD problem.

  13. Summary of the Nevada Applied Ecology Group and correlative programs

    International Nuclear Information System (INIS)

    Friesen, H.N.

    1992-10-01

    This summary document presents results in a broad context; it is not limited to findings of the Nevada Applied Ecology Group. This book is organized to present the findings of the Nevada Applied Ecology Group and correlative programs in accordance with the originally stated objectives of the Nevada Applied Ecology Group. This plan, in essence, traces plutonium from its injection into the environment to movement in the ecosystem to development of cleanup techniques. Information on other radionuclides was also obtained and will be presented briefly. Chapter 1 presents a brief description of the ecological setting of the Test Range Complex. The results of investigations for plutonium distribution are presented in Chapter 2 for the area surrounding the Test Range Complex and in Chapter 3 for on-site locations. Chapters 4 and 5 present the results of investigations concerned with concentrations and movement, respectively, of plutonium in the ecosystem of the Test Range Complex, and Chapter 6 summarizes the potential hazard from this plutonium. Development of techniques for cleanup and treatment is presented in Chapter 7, and the inventory of radionuclides other than plutonium is presented briefly in Chapter 8

  14. A new algorithm for histopathological diagnosis of periprosthetic infection using CD15 focus score and computer program CD15 Quantifier

    Directory of Open Access Journals (Sweden)

    V. Krenn

    2015-01-01

    Full Text Available Introduction. A simple microscopic diagnostic quantification system for neutrophile granulocytes (NG was developed evaluating a single focal point (CD15 focus score which enables the detection of bacterial infection in SLIM (synoviallike interface membrane Additionally a diagnostic algorithm is proposed how to use the CD15 focus score and the quantification software (CD15 Quantifier. Methods. 91 SLIM removed during revision surgery for histopathological diagnosis (hip; n=59 and knee; n=32 underwent histopathological classification according to the SLIM-consensus classification. NG where identified immunohistochemically by means of a CD15-specific monoclonal antibody exhibiting an intense granular cytoplasmic staining pattern. This pattern is different from CD15 expression in macrophages showing a pale and homogenous expression in mononuclear cells. The quantitative evaluation of CD15-positive neutrophils granulocytes (CD15NG used the principle of maximum focal infiltration (focus together with an assessment of a single focal point (approximately 0.3 mm2. This immunohistochemical data made it possible to develop CD15 Quantifier software which automatically quantifies CD15NG. Results. SLIM-cases with positive microbiological diagnosis (n=47 have significantly (p<0.001, Mann-Whitney U test more CD15NG/focal point than cases with negative microbiological diagnosis (n=44. 50 CD15NG/focal point were identified as the optimum threshold when diagnosing infection of periprosthetic joints using the CD15 focus score. If the microbiological findings are used as a ‘gold standard’ the diagnostic sensitivity is 0.83, specificity is 0.864. (PPV: 0.87; NPV: 0.83; accuracy 0.846; AUC: 0.878. The evaluation findings for the preparations using the CD15 Quantifier (n=31 deviated in an average of 12 cells from the histopathological evaluation findings (CD15focus score. From a cell-count greater 62 CD15 Quantifier needs on average 32 seconds less than the

  15. Applied Statistics: From Bivariate through Multivariate Techniques [with CD-ROM

    Science.gov (United States)

    Warner, Rebecca M.

    2007-01-01

    This book provides a clear introduction to widely used topics in bivariate and multivariate statistics, including multiple regression, discriminant analysis, MANOVA, factor analysis, and binary logistic regression. The approach is applied and does not require formal mathematics; equations are accompanied by verbal explanations. Students are asked…

  16. Effect of Applying Chemical Fertilizers on Concentration of Cd, Pb and Zn in Agricultural Soils

    Directory of Open Access Journals (Sweden)

    Hossein Pourmoghadas

    2017-03-01

    Full Text Available Background &Objective:  Nowadays uncontrolled uses of chemical fertilizers which have many heavy metals such as Cadmium, Lead and Zinc in addition have economic problems, cause to serious damages in the environment. Therefore uncontrolled application of fertilizers can cause accumulation contaminants in soil, water sources and increasing in plants and human & animals’ food chain. The main objective of this research was to investigate the effects of chemical fertilizers application to increase heavy metals in agricultural soils at directions to prevent contamination in water sources, agricultural products and the best uses of chemical fertilizers. Methods: In this study, 20 soil samples and 5 useful chemical fertilizer samples were collected and investigated. After fertilizer and soil samples were prepared, digested and filtered, heavy metals were determined with using atomic absorption. Results: The results of this study showed that, Cd in Diammonum phosphate  fertilizer 1.25 times, Super phosphate triple 1.7 times and in Macro granular fertilizer 1.5 times were as much as maximum acceptable concentration in chemical fertilizers. Cadmium concentration in all of the Jarghoye (Isfahan agricultural soil samples 3 to 7 times and in the Mobarake village (Najaf abad agricultural soil samples 10 to 35 times were as much as maximum acceptable concentration in agricultural soils. But Pb and Zn concentration in all of the agricultural soil samples was less than the amount of maximum acceptable concentration. Conclusion: Phosphate chemical fertilizers were positive effects to increase concentration of Pb and Zn in agricultural soils. Therefore, application of the fertilizer must be more attention because of increasing heavy metals in the agriculture soils and probably increasing heavy metals in food chain.  

  17. Applying Best Practices to Florida Local Government Retrofit Programs

    Energy Technology Data Exchange (ETDEWEB)

    McIlvaine, J. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Sutherland, K. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2013-12-01

    In some communities, local government and non-profit entities have funds to purchase and renovate distressed, foreclosed homes for resale in the affordable housing market. Numerous opportunities to improve whole house energy efficiency are inherent in these comprehensive renovations. BA-PIRC worked together in a multi-year field study making recommendations in individual homes, meanwhile compiling improvement costs, projected energy savings, practical challenges, and labor force factors surrounding common energy-related renovation measures. The field study, Phase 1 of this research, resulted in a set of best practices appropriate to the current labor pool and market conditions in central Florida to achieve projected annual energy savings of 15-30% and higher. This report describes Phase 2 of the work where researchers worked with a local government partner to implement and refine the 'current best practices.' A simulation study was conducted to characterize savings potential under three sets of conditions representing varying replacement needs for energy-related equipment and envelope components. The three scenarios apply readily to the general remodeling industry as for renovation of foreclosed homes for the affordable housing market. Our new local government partner, the City of Melbourne, implemented the best practices in a community-scale renovation program that included ten homes in 2012.

  18. Applying Best Practices to Florida Local Government Retrofit Programs

    Energy Technology Data Exchange (ETDEWEB)

    McIlvaine, J. [Building America Partnership for Improved Residential Construction (BA-PIRC), Cocoa, FL (United States); Sutherland, K. [Building America Partnership for Improved Residential Construction (BA-PIRC), Cocoa, FL (United States)

    2013-12-01

    In some communities, local government and non-profit entities have funds to purchase and renovate distressed, foreclosed homes for resale in the affordable housing market. Numerous opportunities to improve whole house energy efficiency are inherent in these comprehensive renovations. BA-PIRC worked together in a multiyear field study making recommendations in individual homes, meanwhile compiling improvement costs, projected energy savings, practical challenges, and labor force factors surrounding common energy-related renovation measures. The field study, Phase 1 of this research, resulted in a set of best practices appropriate to the current labor pool and market conditions in central Florida to achieve projected annual energy savings of 15%-30% and higher. This report describes Phase 2 of the work where researchers worked with a local government partner to implement and refine the "current best practices". A simulation study was conducted to characterize savings potential under three sets of conditions representing varying replacement needs for energy-related equipment and envelope components. The three scenarios apply readily to the general remodeling industry as for renovation of foreclosed homes for the affordable housing market. The new local government partner, the City of Melbourne, implemented the best practices in a community-scale renovation program that included ten homes in 2012.

  19. Applying national survey results for strategic planning and program improvement: the National Diabetes Education Program.

    Science.gov (United States)

    Griffey, Susan; Piccinino, Linda; Gallivan, Joanne; Lotenberg, Lynne Doner; Tuncer, Diane

    2015-02-01

    Since the 1970s, the federal government has spearheaded major national education programs to reduce the burden of chronic diseases in the United States. These prevention and disease management programs communicate critical information to the public, those affected by the disease, and health care providers. The National Diabetes Education Program (NDEP), the leading federal program on diabetes sponsored by the National Institutes of Health (NIH) and the Centers for Disease Control and Prevention (CDC), uses primary and secondary quantitative data and qualitative audience research to guide program planning and evaluation. Since 2006, the NDEP has filled the gaps in existing quantitative data sources by conducting its own population-based survey, the NDEP National Diabetes Survey (NNDS). The NNDS is conducted every 2–3 years and tracks changes in knowledge, attitudes and practice indicators in key target audiences. This article describes how the NDEP has used the NNDS as a key component of its evaluation framework and how it applies the survey results for strategic planning and program improvement. The NDEP's use of the NNDS illustrates how a program evaluation framework that includes periodic population-based surveys can serve as an evaluation model for similar national health education programs.

  20. Early programming and late-acting checkpoints governing the development of CD4 T cell memory.

    Science.gov (United States)

    Dhume, Kunal; McKinstry, K Kai

    2018-04-27

    CD4 T cells contribute to protection against pathogens through numerous mechanisms. Incorporating the goal of memory CD4 T cell generation into vaccine strategies thus offers a powerful approach to improve their efficacy, especially in situations where humoral responses alone cannot confer long-term immunity. These threats include viruses such as influenza that mutate coat proteins to avoid neutralizing antibodies, but that are targeted by T cells that recognize more conserved protein epitopes shared by different strains. A major barrier in the design of such vaccines is that the mechanisms controlling the efficiency with which memory cells form remain incompletely understood. Here, we discuss recent insights into fate decisions controlling memory generation. We focus on the importance of three general cues: interleukin-2, antigen, and costimulatory interactions. It is increasingly clear that these signals have a powerful influence on the capacity of CD4 T cells to form memory during two distinct phases of the immune response. First, through 'programming' that occurs during initial priming, and second, through 'checkpoints' that operate later during the effector stage. These findings indicate that novel vaccine strategies must seek to optimize cognate interactions, during which interleukin-2-, antigen, and costimulation-dependent signals are tightly linked, well beyond initial antigen encounter to induce robust memory CD4 T cells. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  1. Internal electric fields due to piezoelectric and spontaneous polarizations in CdZnO/MgZnO quantum well with various applied electric field effects

    International Nuclear Information System (INIS)

    Jeon, H.C.; Lee, S.J.; Kang, T.W.; Park, S.H.

    2012-01-01

    The strain-induced piezoelectric polarization and the spontaneous polarization can be reduced effectively using the applied electric field in the CdZnO/ZnMgO quantum well (QW) structure with high Cd composition. That is, optical properties as a function of internal and external fields in the CdZnO/ZnMgO QW with various applied electric field result in the increased optical gain due to the fact that the QW potential profile is flattened as a result of the compensation of the internal field by the reverse field as confirmed. These results demonstrate that a high-performance optical device operation can be realized in CdZnO/MgZnO QW structures by reducing the droop phenomenon.

  2. Internal electric fields due to piezoelectric and spontaneous polarizations in CdZnO/MgZnO quantum well with various applied electric field effects

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, H.C. [Quantum-functional Semiconductor Research Center, Dongguk University, Seoul 100-715 (Korea, Republic of); Lee, S.J., E-mail: leesj@dongguk.edu [Quantum-functional Semiconductor Research Center, Dongguk University, Seoul 100-715 (Korea, Republic of); Kang, T.W. [Quantum-functional Semiconductor Research Center, Dongguk University, Seoul 100-715 (Korea, Republic of); Park, S.H. [Department of Electronics Engineering, Catholic University of Daegu, Kyeongbuk 712-702 (Korea, Republic of)

    2012-05-15

    The strain-induced piezoelectric polarization and the spontaneous polarization can be reduced effectively using the applied electric field in the CdZnO/ZnMgO quantum well (QW) structure with high Cd composition. That is, optical properties as a function of internal and external fields in the CdZnO/ZnMgO QW with various applied electric field result in the increased optical gain due to the fact that the QW potential profile is flattened as a result of the compensation of the internal field by the reverse field as confirmed. These results demonstrate that a high-performance optical device operation can be realized in CdZnO/MgZnO QW structures by reducing the droop phenomenon.

  3. 34 CFR 400.9 - What additional requirements govern the Vocational and Applied Technology Education Programs?

    Science.gov (United States)

    2010-07-01

    ... Applied Technology Education Programs? 400.9 Section 400.9 Education Regulations of the Offices of the... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAMS-GENERAL PROVISIONS § 400.9 What additional requirements govern the Vocational and Applied Technology Education Programs? In addition to the Act, applicable...

  4. 34 CFR 403.1 - What is the State Vocational and Applied Technology Education Program?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What is the State Vocational and Applied Technology... TECHNOLOGY EDUCATION PROGRAM General § 403.1 What is the State Vocational and Applied Technology Education Program? (a) Under the State Vocational and Applied Technology Education Program, the Secretary makes...

  5. 34 CFR 400.4 - What definitions apply to the Vocational and Applied Technology Education Programs?

    Science.gov (United States)

    2010-07-01

    ... the Interior for the administration of programs under the Indian Self-Determination and Education... standards, and the purpose for which this determination is being made, that the institution will meet the... programs designed to eliminate sex bias, and individuals in correctional institutions. Specific job...

  6. Volcanoes of México: An Interactive CD-ROM From the Smithsonian's Global Volcanism Program

    Science.gov (United States)

    Siebert, L.; Kimberly, P.; Calvin, C.; Luhr, J. F.; Kysar, G.

    2002-12-01

    The Smithsonian Institution's Global Volcanism Program is nearing completion of an interactive CD-ROM, the Volcanoes of México. This CD is the second in a series sponsored by the U.S. Department of Energy Office of Geothermal Technologies to collate Smithsonian data on Quaternary volcanism as a resource for the geothermal community. It also has utility for those concerned with volcanic hazard and risk mitgation as well as an educational tool for those interested in Mexican volcanism. We acknowledge the significant contributions of many Mexican volcanologists to the eruption reports, data, and images contained in this CD, in particular those contributions of the Centro Nacional de Prevencion de Desastres (CENAPRED), the Colima Volcano Observatory of the University of Colima, and the Universidad Nacional Autónoma de México (UNAM). The Volcanoes of México CD has a format similar to that of an earlier Smithsonian CD, the Volcanoes of Indonesia, but also shows Pleistocene volcanic centers and additional data on geothermal sites. A clickable map of México shows both Holocene and Pleistocene volcanic centers and provides access to individual pages on 67 volcanoes ranging from Cerro Prieto in Baja California to Tacaná on the Guatemalan border. These include geographic and geologic data on individual volcanoes (as well as a brief paragraph summarizing the geologic history) along with tabular eruption chronologies, eruptive characteristics, and eruptive volumes, when known. Volcano data are accessible from both geographical and alphabetical searches. A major component of the CD is more than 400 digitized images illustrating the morphology of volcanic centers and eruption processes and deposits, providing a dramatic visual primer to the country's volcanoes. Images of specific eruptions can be directly linked to from the eruption chronology tables. The Volcanoes of México CD includes monthly reports and associated figures and tables cataloging volcanic activity in M

  7. The marketing concept applied to an education program.

    Science.gov (United States)

    Parks, S C; Moody, D L; Barbrow, E P

    1984-09-01

    Dietetic education programs seeking to maintain their enrollment levels may find it necessary to adopt more sophisticated marketing strategies. This article describes the application of the marketing process to an extended degree dietetic program that serves a national audience. It also presents a strategy for initiating a marketing study and marketing orientation by analyzing its internal program data. The article discusses the specific market characteristics of the program's primary market segments, and it presents further implications for dietitians at work in health care facilities, in businesses, or in private practice.

  8. Programmed death-1 (PD-1)-dependent functional impairment of CD4(+) T cells in recurrent genital papilloma.

    Science.gov (United States)

    Chang, Dong-Yeop; Song, Sang Hoon; You, Sooseong; Lee, Jino; Kim, Jihye; Racanelli, Vito; Son, Hwancheol; Shin, Eui-Cheol

    2014-08-01

    Genital papilloma is caused by human papilloma virus (HPV) infection and recurs frequently. Although T cells are known to play a critical role in the control of HPV infection and papilloma development, the function and phenotype of these cells in the lesion remain to be elucidated. In the present study, we examined the function and phenotype of CD4(+) T cells isolated from the lesions of primary (n = 9) and recurrent (n = 11) genital papillomas. In recurrent papillomas, the frequency of proliferating (Ki-67(+)) CD4(+) T cells was significantly reduced compared with primary papillomas. Cytokine production was evaluated by intracellular cytokine staining in anti-CD3/anti-CD28-stimulated CD4(+) T cells. CD4(+) T cells from recurrent lesions showed impaired production of IL-2, IFN-γ, and TNF-α. Of interest, the frequency of cytokine-producing CD4(+) T cells significantly correlated with the frequency of Ki-67(+)CD4(+) T cells. We also studied expression of programmed death-1 (PD-1), a T-cell exhaustion marker. The frequency of PD-1(+)CD4(+) T cells was significantly increased in recurrent lesions and inversely correlated with the frequency of cytokine-producing CD4(+) T cells. The functional significance of PD-1 expression was determined in blocking assays with anti-PD-L1, which restored cytokine production of CD4(+) T cells from recurrent lesions. Taken together, in recurrent genital papilloma lesions, proliferation, and cytokine production by CD4(+) T cells are impaired and the PD-1/PD-L1 interaction is responsible for the functional impairment of CD4(+) T cells.

  9. Acquired transcriptional programming in functional and exhausted virus-specific CD8 T cells.

    Science.gov (United States)

    Youngblood, Ben; Wherry, E John; Ahmed, Rafi

    2012-01-01

    Failure to control viral infections such as HIV results in T-cell receptor (TCR) and inhibitory receptor driven exhaustion of antigen-specific T cells. Persistent signaling by these receptors during chronic viral infection sculpts the transcriptional regulatory programs of virus-specific T cells. The resulting gene expression profile is tailored to temper the potentially damaging effector functions of cytotoxic T cells and adapt them to an antigen-rich and inflammation-rich environment. Here we review recent studies investigating mechanisms of transcriptional regulation of effector, functional memory, and exhausted T-cell functions during acute versus chronic infections. Patterns of gene expression in virus-specific CD8 T cells are a result of a combination of pro and inhibitory signals from antigen presentation (TCR-mediated) and co-inhibitory receptor ligation (PD-1, 2B4). Further, memory-specific transcriptional regulation of 2B4 expression and signaling impose a self-limiting secondary effector response to a prolonged viral infection. Additionally, differentiation of functional memory CD8 T cells is coupled with acquisition of a repressive epigenetic program for PD-1 expression. However, chronic infection provides a signal that blocks the acquisition of these epigenetic modifications reinforcing the suppression of cytotoxic lymphocyte (CTL) functions in exhausted cells. Current findings suggest that the mechanism(s) that delineate functional memory versus exhaustion are coupled with acquisition of transcriptional programs at the effector stage of differentiation, reinforced by cessation or persistence of TCR signaling.

  10. CD4(+) type II NKT cells mediate ICOS and programmed death-1-dependent regulation of type 1 diabetes.

    Science.gov (United States)

    Kadri, Nadir; Korpos, Eva; Gupta, Shashank; Briet, Claire; Löfbom, Linda; Yagita, Hideo; Lehuen, Agnes; Boitard, Christian; Holmberg, Dan; Sorokin, Lydia; Cardell, Susanna L

    2012-04-01

    Type 1 diabetes (T1D) is a chronic autoimmune disease that results from T cell-mediated destruction of pancreatic β cells. CD1d-restricted NKT lymphocytes have the ability to regulate immunity, including autoimmunity. We previously demonstrated that CD1d-restricted type II NKT cells, which carry diverse TCRs, prevented T1D in the NOD mouse model for the human disease. In this study, we show that CD4(+) 24αβ type II NKT cells, but not CD4/CD8 double-negative NKT cells, were sufficient to downregulate diabetogenic CD4(+) BDC2.5 NOD T cells in adoptive transfer experiments. CD4(+) 24αβ NKT cells exhibited a memory phenotype including high ICOS expression, increased cytokine production, and limited display of NK cell markers, compared with double-negative 24αβ NKT cells. Blocking of ICOS or the programmed death-1/programmed death ligand 1 pathway was shown to abolish the regulation that occurred in the pancreas draining lymph nodes. To our knowledge, these results provide for the first time cellular and molecular information on how type II CD1d-restricted NKT cells regulate T1D.

  11. Constraint-based scheduling applying constraint programming to scheduling problems

    CERN Document Server

    Baptiste, Philippe; Nuijten, Wim

    2001-01-01

    Constraint Programming is a problem-solving paradigm that establishes a clear distinction between two pivotal aspects of a problem: (1) a precise definition of the constraints that define the problem to be solved and (2) the algorithms and heuristics enabling the selection of decisions to solve the problem. It is because of these capabilities that Constraint Programming is increasingly being employed as a problem-solving tool to solve scheduling problems. Hence the development of Constraint-Based Scheduling as a field of study. The aim of this book is to provide an overview of the most widely used Constraint-Based Scheduling techniques. Following the principles of Constraint Programming, the book consists of three distinct parts: The first chapter introduces the basic principles of Constraint Programming and provides a model of the constraints that are the most often encountered in scheduling problems. Chapters 2, 3, 4, and 5 are focused on the propagation of resource constraints, which usually are responsibl...

  12. The DEVELOP National Program's Strategy for Communicating Applied Science Outcomes

    Science.gov (United States)

    Childs-Gleason, L. M.; Ross, K. W.; Crepps, G.; Favors, J.; Kelley, C.; Miller, T. N.; Allsbrook, K. N.; Rogers, L.; Ruiz, M. L.

    2016-12-01

    NASA's DEVELOP National Program conducts rapid feasibility projects that enable the future workforce and current decision makers to collaborate and build capacity to use Earth science data to enhance environmental management and policy. The program communicates its results and applications to a broad spectrum of audiences through a variety of methods: "virtual poster sessions" that engage the general public through short project videos and interactive dialogue periods, a "Campus Ambassador Corps" that communicates about the program and its projects to academia, scientific and policy conference presentations, community engagement activities and end-of-project presentations, project "hand-offs" providing results and tools to project partners, traditional publications (both gray literature and peer-reviewed), an interactive website project gallery, targeted brochures, and through multiple social media venues and campaigns. This presentation will describe the various methods employed by DEVELOP to communicate the program's scientific outputs, target audiences, general statistics, community response and best practices.

  13. Applied Research of Enterprise Cost Control Based on Linear Programming

    Directory of Open Access Journals (Sweden)

    Yu Shuo

    2015-01-01

    This paper researches the enterprise cost control through the linear programming model, and analyzes the restriction factors of the labor of enterprise production, raw materials, processing equipment, sales price, and other factors affecting the enterprise income, so as to obtain an enterprise cost control model based on the linear programming. This model can calculate rational production mode in the case of limited resources, and acquire optimal enterprise income. The production guiding program and scheduling arrangement of the enterprise can be obtained through calculation results, so as to provide scientific and effective guidance for the enterprise production. This paper adds the sensitivity analysis in the linear programming model, so as to learn about the stability of the enterprise cost control model based on linear programming through the sensitivity analysis, and verify the rationality of the model, and indicate the direction for the enterprise cost control. The calculation results of the model can provide a certain reference for the enterprise planning in the market economy environment, which have strong reference and practical significance in terms of the enterprise cost control.

  14. 34 CFR 280.3 - What regulations apply to this program?

    Science.gov (United States)

    2010-07-01

    ... SECONDARY EDUCATION, DEPARTMENT OF EDUCATION MAGNET SCHOOLS ASSISTANCE PROGRAM General § 280.3 What regulations apply to this program? The following regulations apply to the Magnet Schools Assistance Program: (a) The Education Department General Administrative Regulations (EDGAR), 34 CFR parts 75 (Direct...

  15. 49 CFR 26.103 - What enforcement actions apply in FHWA and FTA programs?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What enforcement actions apply in FHWA and FTA... Enforcement § 26.103 What enforcement actions apply in FHWA and FTA programs? The provisions of this section apply to enforcement actions under FHWA and FTA programs: (a) Noncompliance complaints. Any person who...

  16. Applying Model Checking to Industrial-Sized PLC Programs

    CERN Document Server

    AUTHOR|(CDS)2079190; Darvas, Daniel; Blanco Vinuela, Enrique; Tournier, Jean-Charles; Bliudze, Simon; Blech, Jan Olaf; Gonzalez Suarez, Victor M

    2015-01-01

    Programmable logic controllers (PLCs) are embedded computers widely used in industrial control systems. Ensuring that a PLC software complies with its specification is a challenging task. Formal verification has become a recommended practice to ensure the correctness of safety-critical software but is still underused in industry due to the complexity of building and managing formal models of real applications. In this paper, we propose a general methodology to perform automated model checking of complex properties expressed in temporal logics (\\eg CTL, LTL) on PLC programs. This methodology is based on an intermediate model (IM), meant to transform PLC programs written in various standard languages (ST, SFC, etc.) to different modeling languages of verification tools. We present the syntax and semantics of the IM and the transformation rules of the ST and SFC languages to the nuXmv model checker passing through the intermediate model. Finally, two real cases studies of \\CERN PLC programs, written mainly in th...

  17. Resources available for applying metrics in security and safety programming.

    Science.gov (United States)

    Luizzo, Anthony

    2016-01-01

    Incorporating metrics into security surveys has been championed as a better way of substantiating program-related effectiveness and expenditures. Although security surveys have been aroundfor well over 40 years, rarely, if ever, have metric-related strategies been part of the equation, the author says. In this article, he cites several published articles and research findings available to security professionals and their surveyors that may give them the expertise and confidence they need to make use of this valuable tool.

  18. Object oriented programming techniques applied to device access and control

    International Nuclear Information System (INIS)

    Goetz, A.; Klotz, W.D.; Meyer, J.

    1992-01-01

    In this paper a model, called the device server model, has been presented for solving the problem of device access and control faced by all control systems. Object Oriented Programming techniques were used to achieve a powerful yet flexible solution. The model provides a solution to the problem which hides device dependancies. It defines a software framework which has to be respected by implementors of device classes - this is very useful for developing groupware. The decision to implement remote access in the root class means that device servers can be easily integrated in a distributed control system. A lot of the advantages and features of the device server model are due to the adoption of OOP techniques. The main conclusion that can be drawn from this paper is that 1. the device access and control problem is adapted to being solved with OOP techniques, 2. OOP techniques offer a distinct advantage over traditional programming techniques for solving the device access problem. (J.P.N.)

  19. Implementation of a management applied program for solid radioactive waste

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Y. H.; Kim, T. K.; Kang, I. S.; Cho, H. S.; Son, J. S. [KAERI, Taejon (Korea, Republic of)

    2004-07-01

    Solid radioactive wastes are generated from the Post-irradiated Fuel Examination Facility, the Irradiated Material Examination Facility, the Research Reactor, and the laboratories at KAERI. A data collection of a solid radioactive waste treatment process of a research organization became necessary while developing the RAWMIS(Radioactive Waste Management Integration System) which it can generate personal history management for efficient management of a waste, documents, all kinds of statistics. This paper introduces an input and output application program design to do to database with data in the results and a stream process of a treatment that analyzed the waste occurrence present situation and data by treatment process. Data on the actual treatment process that is not limited experiment improve by a document, human traces, saving of material resources and improve with efficiency of tracking about a radioactive waste and a process and give help to radioactive waste material balance and inventory study.

  20. Data Processing and Programming Applied to an Environmental Radioactivity Laboratory

    International Nuclear Information System (INIS)

    Trinidad, J. A.; Gasco, C.; Palacios, M. A.

    2009-01-01

    This report is the original research work presented for the attainment of the author master degree and its main objective has been the resolution -by means of friendly programming- of some of the observed problems in the environmental radioactivity laboratory belonging to the Department of Radiological Surveillance and Environmental Radioactivity from CIEMAT. The software has been developed in Visual Basic for applications in Excel files and it solves by macro orders three of the detected problems: a) calculation of characteristic limits for the measurements of the beta total and beta rest activity concentrations according to standards MARLAP, ISO and UNE and the comparison of the three results b) Pb-210 and Po-210 decontamination factor determination in the ultra-low level Am-241 analysis in air samples by alpha spectrometry and c) comparison of two analytical techniques for measuring Pb-210 in air ( direct-by gamma spectrometry- and indirect -by radiochemical separation and alpha spectrometry). The organization processes of the different excel files implied in the subroutines, calculations and required formulae are explained graphically for its comprehension. The advantage of using this kind of programmes is based on their versatility and the ease for obtaining data that lately are required by tables that can be modified as time goes by and the laboratory gets more data with the special applications for describing a method (Pb-210 decontamination factors for americium analysis in air) or comparing temporal series of Pb-210 data analysed by different methods (Pb-210 in air). (Author)

  1. Shippingport Atomic Power Station decommissioning program and applied technology

    Energy Technology Data Exchange (ETDEWEB)

    Crimi, F P; Skavdahl, R E

    1985-01-01

    The Shippingport Station decommissioning project is the first decommissioning of a large scale nuclear power plant, and also the first nuclear power plant to be decommissioned which has continued the power operation as long as 25 years. The nuclear facilities which have been decommissioned so far have operated for shorter period and were small as compared with commercial power reactors, but the experience gained by those decommissionings as well as that gained by nuclear plant maintenance and modification has helped to establish the technology and cost basis for Shippingport and future decommissioning projects. In this paper, the current status of the preparation being made by the General Electric Co., its subcontractor and the US Department of Energy for starting the decommissioning phase of the Shippingport Atomic Power Station is described. Also remote metal cutting, decontamination, concrete removal, the volume reduction of liquids and solids and robotics which will be applied to the project are discussed. The Shippingport Station is a 72 MWe PWR plant having started operation in 1957, and permanently shut down in 1982, after having generated over 7.4 billion kWh of electricity.

  2. 49 CFR 26.105 - What enforcement actions apply in FAA programs?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What enforcement actions apply in FAA programs? 26... Enforcement § 26.105 What enforcement actions apply in FAA programs? (a) Compliance with all requirements of this part by airport sponsors and other recipients of FAA financial assistance is enforced through the...

  3. 34 CFR 661.4 - What definitions apply to the Business and International Education Program?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What definitions apply to the Business and... Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION BUSINESS AND INTERNATIONAL EDUCATION PROGRAM General § 661.4 What definitions apply to the Business and International Education Program...

  4. A Program Applying Professional Safety Basics in Construction Projects

    Directory of Open Access Journals (Sweden)

    Entisar Kadhim Rasheed

    2016-04-01

    Full Text Available When industrial and constructional renaissance started in the world, the great interest was going on towards the equipment’s, which was the first mean for production. After industry was settled the interest was going on towards the men ship which manpower on which the production depends. It was approved that it represents the basic part in all of the processes and the protection of those individuals against dangers of these equipment’s, industry and its accidents was the basic things which was studied in many researches until it crystallized in general principles for all industries and other take care in each industry. The professional safety is concerned as restrict which aims to take care of humanitarian and material principles also to raise the production of these principles, in the aspect of safety, health and providing the suitable healthy condition to the worker so he can feel safety, confidence and sociological settle, this will increase the production. So In order to maintain the manpower of business risks and to enable them to fulfill their role better to increase production and improve the quality and maintain the machine and supporting the national economy and keep pace with industrial developments and technological came the idea of research to focus on the importance of studying the subject of occupational safety by conducting a field survey to see the reality of professional safety in the relevant departments and work sites and through a questionnaire on the subject and conduct personal interviews with those concerned in this area and to prepare a program for the application of professional safety for each resource (labor, machines, materials, money in construction sites and departments concerned.

  5. Direct Analysis of JV-Curves Applied to an Outdoor-Degrading CdTe Module (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Jordan, D; Kurtz, S.; Ulbrich, C.; Gerber, A.; Rau, U.

    2014-03-01

    We present the application of a phenomenological four parameter equation to fit and analyze regularly measured current density-voltage JV curves of a CdTe module during 2.5 years of outdoor operation. The parameters are physically meaningful, i.e. the short circuit current density Jsc, open circuit voltage Voc and differential resistances Rsc, and Roc. For the chosen module, the fill factor FF degradation overweighs the degradation of Jsc and Voc. Interestingly, with outdoor exposure, not only the conductance at short circuit, Gsc, increases but also the Gsc(Jsc)-dependence. This is well explained with an increase in voltage dependent charge carrier collection in CdTe.

  6. Monte Carlo simulation of the response functions of Cd Te detectors to be applied in X-rays spectroscopy

    International Nuclear Information System (INIS)

    Tomal, A.; Lopez G, A. H.; Santos, J. C.; Costa, P. R.

    2014-08-01

    In this work, the energy response functions of a Cd Te detector were obtained by Monte Carlo simulation in the energy range from 5 to 150 keV, using the Penelope code. The response functions simulated included the finite detector resolution and the carrier transport. The simulated energy response matrix was validated through comparison with experimental results obtained for radioactive sources. In order to investigate the influence of the correction by the detector response at diagnostic energy range, x-ray spectra were measured using a Cd Te detector (model Xr-100-T, Amptek), and then corrected by the energy response of the detector using the stripping procedure. Results showed that the Cd Te exhibit good energy response at low energies (below 40 keV), showing only small distortions on the measured spectra. For energies below about 70 keV, the contribution of the escape of Cd- and Te-K x-rays produce significant distortions on the measured x-ray spectra. For higher energies, the most important correction is the detector efficiency and the carrier trapping effects. The results showed that, after correction by the energy response, the measured spectra are in good agreement with those provided by different models from the literature. Finally, our results showed that the detailed knowledge of the response function and a proper correction procedure are fundamental for achieve more accurate spectra from which several qualities parameters (i.e. half-value layer, effective energy and mean energy) can be determined. (Author)

  7. Monte Carlo simulation of the response functions of Cd Te detectors to be applied in X-rays spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Tomal, A. [Universidade Federale de Goias, Instituto de Fisica, Campus Samambaia, 74001-970, Goiania, (Brazil); Lopez G, A. H.; Santos, J. C.; Costa, P. R., E-mail: alessandra_tomal@yahoo.com.br [Universidade de Sao Paulo, Instituto de Fisica, Rua du Matao Travessa R. 187, Cidade Universitaria, 05508-090 Sao Paulo (Brazil)

    2014-08-15

    In this work, the energy response functions of a Cd Te detector were obtained by Monte Carlo simulation in the energy range from 5 to 150 keV, using the Penelope code. The response functions simulated included the finite detector resolution and the carrier transport. The simulated energy response matrix was validated through comparison with experimental results obtained for radioactive sources. In order to investigate the influence of the correction by the detector response at diagnostic energy range, x-ray spectra were measured using a Cd Te detector (model Xr-100-T, Amptek), and then corrected by the energy response of the detector using the stripping procedure. Results showed that the Cd Te exhibit good energy response at low energies (below 40 keV), showing only small distortions on the measured spectra. For energies below about 70 keV, the contribution of the escape of Cd- and Te-K x-rays produce significant distortions on the measured x-ray spectra. For higher energies, the most important correction is the detector efficiency and the carrier trapping effects. The results showed that, after correction by the energy response, the measured spectra are in good agreement with those provided by different models from the literature. Finally, our results showed that the detailed knowledge of the response function and a proper correction procedure are fundamental for achieve more accurate spectra from which several qualities parameters (i.e. half-value layer, effective energy and mean energy) can be determined. (Author)

  8. Using Health Data - Applying Technology to Work Smarter Grain Heather Proctor Paula Using Health Data - Applying Technology to Work Smarter 276 + CD Elsevier 9780729538893 0729538893 [Formula: see text].

    Science.gov (United States)

    2010-05-26

    The title gives the impression that this book will be about the collection and analysis of healthcare data, but its actual focus is how to use the Microsoft Office 2007 suite of programs in the healthcare setting.

  9. The Australian Master of Applied Epidemiology Program: Looking back, moving forward.

    Science.gov (United States)

    Davis, Stephanie; Patel, Mahomed S; Fearnley, Emily; Viney, Kerri; Kirk, Martyn

    2016-09-30

    The Master of Applied Epidemiology Program is Australia's Field Epidemiology Training Program. It was established in 1991 and was run out of the National Centre for Population Health (NCEPH) at the Australian National University. The Program has a strong track record in using field-based training to produce competent applied epidemiologists who have contributed to public health in Australia and globally. A new funding model for the program was implemented in 2012, backed by funds from field placement partners and NCEPH. In this paper we review the program's origins and achievements, discuss the ongoing needs of the program and outline a vision for the future. Commun Dis Intell 2016;40(3):E326-E333.

  10. Applying Matched Sampling to Evaluate a University Tutoring Program for First-Year Students

    Science.gov (United States)

    Walvoord, Mark E.; Pleitz, Jacob D.

    2016-01-01

    Our study used a case-control matching design to assess the influence of a voluntary tutoring program in improving first-year students' Grade Point Averages (GPA). To evaluate program effectiveness, we applied case-control matching to obtain 215 pairs of students with or without participation in tutoring, but matched on high school GPA and…

  11. 34 CFR 660.2 - Who is eligible to apply for grants under this program?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Who is eligible to apply for grants under this program? 660.2 Section 660.2 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION THE INTERNATIONAL RESEARCH AND STUDIES PROGRAM...

  12. Applying Coaching Strategies to Support Youth- and Family-Focused Extension Programming

    Science.gov (United States)

    Olson, Jonathan R.; Hawkey, Kyle R.; Smith, Burgess; Perkins, Daniel F.; Borden, Lynne M.

    2016-01-01

    In this article, we describe how a peer-coaching model has been applied to support community-based Extension programming through the Children, Youth, and Families at Risk (CYFAR) initiative. We describe the general approaches to coaching that have been used to help with CYFAR program implementation, evaluation, and sustainability efforts; we…

  13. 42 CFR 50.402 - To what program do these regulations apply?

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false To what program do these regulations apply? 50.402 Section 50.402 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS POLICIES OF GENERAL APPLICABILITY Public Health Service Grant Appeals Procedure § 50.402 To what program do...

  14. 42 CFR 59.1 - To what programs do these regulations apply?

    Science.gov (United States)

    2010-10-01

    ... FOR FAMILY PLANNING SERVICES Project Grants for Family Planning Services § 59.1 To what programs do... 42 Public Health 1 2010-10-01 2010-10-01 false To what programs do these regulations apply? 59.1... of voluntary family planning projects. These projects shall consist of the educational, comprehensive...

  15. 34 CFR 403.117 - What definitions apply to the Postsecondary and Adult Vocational Education Programs?

    Science.gov (United States)

    2010-07-01

    ... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAM What Kinds of Activities Does the Secretary Assist Under... that— (i) Admits as regular students only persons having a certificate of graduation from a school... of compulsory school attendance; (ii) Is legally authorized within the State to provide a program of...

  16. 34 CFR 637.3 - What regulations apply to the Minority Science and Engineering Improvement Program?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What regulations apply to the Minority Science and... Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION MINORITY SCIENCE AND ENGINEERING IMPROVEMENT PROGRAM General § 637.3 What regulations apply to the Minority Science and Engineering...

  17. 34 CFR 637.4 - What definitions apply to the Minority Science and Engineering Improvement Program?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What definitions apply to the Minority Science and... Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION MINORITY SCIENCE AND ENGINEERING IMPROVEMENT PROGRAM General § 637.4 What definitions apply to the Minority Science and Engineering...

  18. CD40L induces functional tunneling nanotube networks exclusively in dendritic cells programmed by mediators of type 1 immunity.

    Science.gov (United States)

    Zaccard, Colleen R; Watkins, Simon C; Kalinski, Pawel; Fecek, Ronald J; Yates, Aarika L; Salter, Russell D; Ayyavoo, Velpandi; Rinaldo, Charles R; Mailliard, Robbie B

    2015-02-01

    The ability of dendritic cells (DC) to mediate CD4(+) T cell help for cellular immunity is guided by instructive signals received during DC maturation, as well as the resulting pattern of DC responsiveness to the Th signal, CD40L. Furthermore, the professional transfer of antigenic information from migratory DC to lymph node-residing DC is critical for the effective induction of cellular immune responses. In this study we report that, in addition to their enhanced IL-12p70 producing capacity, human DC matured in the presence of inflammatory mediators of type 1 immunity are uniquely programmed to form networks of tunneling nanotube-like structures in response to CD40L-expressing Th cells or rCD40L. This immunologic process of DC reticulation facilitates intercellular trafficking of endosome-associated vesicles and Ag, but also pathogens such HIV-1, and is regulated by the opposing roles of IFN-γ and IL-4. The initiation of DC reticulation represents a novel helper function of CD40L and a superior mechanism of intercellular communication possessed by type 1 polarized DC, as well as a target for exploitation by pathogens to enhance direct cell-to-cell spread. Copyright © 2015 by The American Association of Immunologists, Inc.

  19. HIV-1 Tat affects the programming and functionality of human CD8⁺ T cells by modulating the expression of T-box transcription factors.

    Science.gov (United States)

    Sforza, Fabio; Nicoli, Francesco; Gallerani, Eleonora; Finessi, Valentina; Reali, Eva; Cafaro, Aurelio; Caputo, Antonella; Ensoli, Barbara; Gavioli, Riccardo

    2014-07-31

    HIV infection is characterized by several immune dysfunctions of both CD8⁺ and CD4⁺ T cells as hyperactivation, impairment of functionality and expansion of memory T cells. CD8⁺ T-cell dysfunctions have been associated with increased expression of T-bet, Eomesdermin and pro-inflammatory cytokines, and with down-regulation of CD127. The HIV-1 trans-activator of transcription (Tat) protein, which is released by infected cells and detected in tissues of HIV-positive individuals, is known to contribute to the dysregulation of CD4⁺ T cells; however, its effects on CD8⁺ T cells have not been investigated. Thus, in this study, we sought to address whether Tat may affect CD8⁺ T-cell functionality and programming. CD8⁺ T cells were activated by T-cell receptor engagement in the presence or absence of Tat. Cytokine production, killing capacity, surface phenotype and expression of transcription factors important for T-cell programming were evaluated. Tat favors the secretion of interleukin-2, interferon-γ and granzyme B in CD8⁺ T cells. Behind this functional modulation we observed that Tat increases the expression of T-bet, Eomesdermin, Blimp-1, Bcl-6 and Bcl-2 in activated but not in unstimulated CD8⁺ T lymphocytes. This effect is associated with the down-regulation of CD127 and the up-regulation of CD27. Tat deeply alters the programming and functionality of CD8⁺ T lymphocytes.

  20. Integration of KESS III models in ATHLET-CD and contributions to program verification. Final report

    International Nuclear Information System (INIS)

    Bruder, M.; Schatz, A.

    1994-07-01

    The development of the computer code ATHLET-CD is a contribution to the reactor safety research. ATHLET-CD is an extension of the system code ATHLET by core degradation models especially of the modular software package KESS. The aim of the ATHLET-CD development is the simulation of severe accident sequences from their initialisation to severe core degradation in a continous manner. In the framework of this project the ATHLET-CD development has been focused on the integration of KESS model like the control rod model as well as the models describing chemical interactions and material relocation along a rod and fission product release. The present ATHLET-CD version is able to describe severe accidents in a PWR up to the early core degradation (relocation of material along a rod surface in axial direction). Contributions to the verification of ATHLET-CD comprised calculations of the experiments PHEBUS AIC and PBF SFD 1-4. The PHEBUS AIC calculation was focused on the examination of the control rod model whereas the PBF SFD 1-4 claculation served to check the models describing melting, material relocation and fission product release. (orig.)

  1. 34 CFR 400.1 - What is the purpose of the Vocational and Applied Technology Education Programs?

    Science.gov (United States)

    2010-07-01

    ... Technology Education Programs? 400.1 Section 400.1 Education Regulations of the Offices of the Department of... APPLIED TECHNOLOGY EDUCATION PROGRAMS-GENERAL PROVISIONS § 400.1 What is the purpose of the Vocational and Applied Technology Education Programs? (a) The purpose of the Vocational and Applied Technology Education...

  2. Development and testing of a CD-ROM program for improving adolescent knowledge of inflammatory bowel disease.

    Science.gov (United States)

    Boamah, Lynelle M; Bohren, Janet R; Pentiuk, Scott; Baker, Raymond; Yi, Michael; Moyer, M Susan

    2010-05-01

    The aim of this study was to design a theory-based educational program for adolescents with inflammatory bowel disease (IBD) using an interactive multimedia CD-ROM and to test its effectiveness in improving knowledge in IBD. Curriculum-based instruction using educational theory and principles was designed for adolescents on an interactive multimedia CD-ROM. Twenty subjects completed summative evaluation of the CD-ROM measuring gain in knowledge about IBD immediately and 9 months after instruction. Subjects found the CD-ROM to be informative, appealing, and easy to use. The mean baseline score of the adolescents on the Crohn's and Colitis Knowledge questionnaire was 12.2 (standard deviation 5.14, range 3-24). After an average of 30 minutes of self-directed learning, adolescent subjects increased their posttest score to a mean of 19.8, a gain of 7.6 points over baseline (95% confidence interval 5.2-10.1, P < 0.0001). Knowledge of medications, disease complications, and gastrointestinal structure and function was gained and retained upon retesting at 9 months with a mean Crohn's and Colitis Knowledge questionnaire score of 17.5 (standard deviation 3.9, range 12-26), which was still an improvement over the mean pretest knowledge score of 12.2 (P < 0.001). Adolescents with IBD have low baseline knowledge about their disease. A rigorously developed interactive educational tool is now available for instructing adolescent patients about their IBD.

  3. Applied structural and solid mechanics section: 1983 review and 1984 programs

    International Nuclear Information System (INIS)

    Chadha, J.A.

    1984-01-01

    This report reviews briefly the applied research and problem solving work carried out by the Applied Structural and Solid Mechanics Section during 1983. In 1983 there was a strong demand for services in the areas of theroretical and experimental stress analysis, heat transfer analysis, nonlinear analysis, and general structural analyses related to nuclear and thermal power plant, and transmission line components. Development of capabilities in these areas progressed well. Proposed work programs for 1984 are outlined in this report

  4. miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation.

    Science.gov (United States)

    Ban, Young Ho; Oh, Se-Chan; Seo, Sang-Hwan; Kim, Seok-Min; Choi, In-Pyo; Greenberg, Philip D; Chang, Jun; Kim, Tae-Don; Ha, Sang-Jun

    2017-09-12

    MicroRNA (miR)-150 is a developmental regulator of several immune-cell types, but its role in CD8 + T cells is largely unexplored. Here, we show that miR-150 regulates the generation of memory CD8 + T cells. After acute virus infection, miR-150 knockout (KO) mice exhibited an accelerated differentiation of CD8 + T cells into memory cells and improved production of effector cytokines. Additionally, miR-150 KO CD8 + T cells displayed an enhanced recall response and improved protection against infections with another virus and bacteria. We found that forkhead box O1 (Foxo1) and T cell-specific transcription factor 1 (TCF1) are upregulated during the early activation phase in miR-150 KO CD8 + T cells and that miR-150 directly targets and suppresses Foxo1. These results suggest that miR-150-mediated suppression of Foxo1 regulates the balance between effector and memory cell differentiation, which might aid in the development of improved vaccines and T cell therapeutics. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  5. Human CD141+ Dendritic Cell and CD1c+ Dendritic Cell Undergo Concordant Early Genetic Programming after Activation in Humanized Mice In Vivo

    Directory of Open Access Journals (Sweden)

    Yoshihito Minoda

    2017-10-01

    Full Text Available Human immune cell subsets develop in immunodeficient mice following reconstitution with human CD34+ hematopoietic stem cells. These “humanized” mice are useful models to study human immunology and human-tropic infections, autoimmunity, and cancer. However, some human immune cell subsets are unable to fully develop or acquire full functional capacity due to a lack of cross-reactivity of many growth factors and cytokines between species. Conventional dendritic cells (cDCs in mice are categorized into cDC1, which mediate T helper (Th1 and CD8+ T cell responses, and cDC2, which mediate Th2 and Th17 responses. The likely human equivalents are CD141+ DC and CD1c+ DC subsets for mouse cDC1 and cDC2, respectively, but the extent of any interspecies differences is poorly characterized. Here, we exploit the fact that human CD141+ DC and CD1c+ DC develop in humanized mice, to further explore their equivalency in vivo. Global transcriptome analysis of CD141+ DC and CD1c+ DC isolated from humanized mice demonstrated that they closely resemble those in human blood. Activation of DC subsets in vivo, with the TLR3 ligand poly I:C, and the TLR7/8 ligand R848 revealed that a core panel of genes consistent with DC maturation status were upregulated by both subsets. R848 specifically upregulated genes associated with Th17 responses by CD1c+ DC, while poly I:C upregulated IFN-λ genes specifically by CD141+ DC. MYCL expression, known to be essential for CD8+ T cell priming by mouse DC, was specifically induced in CD141+ DC after activation. Concomitantly, CD141+ DC were superior to CD1c+ DC in their ability to prime naïve antigen-specific CD8+ T cells. Thus, CD141+ DC and CD1c+ DC share a similar activation profiles in vivo but also have induce unique signatures that support specialized roles in CD8+ T cell priming and Th17 responses, respectively. In combination, these data demonstrate that humanized mice provide an attractive and tractable model to study

  6. Summaries of FY 1986 research in the Applied Plasma Physics Fusion Theory Program

    International Nuclear Information System (INIS)

    1987-12-01

    The Theory Program is charged with supporting the development of theories and models of plasmas for the fusion research effort. This work ranges from first-principles analysis of elementary plasma processes to empirical simulation of specific experiments. The Theory Program supports research by industrial contractors, US government laboratories, and universities. The university support also helps to fulfill the DOE mission of training scientists for the fusion program. The Theory Program is funded through the Fusion Theory Branch, Division of Applied Plasma Physics in the Office of Fusion Energy. The work is divided among 31 institutions, of which 19 are universities, five are industrial contractors, and seven are US government laboratories; see Table 1 for a complete list. The FY 1986 Theory Program budget was divided among theory types: toroidal, mirror, alternate concept, generic, and atomic. Device modeling is included among the other funding categories, and is not budgeted separately

  7. 34 CFR 614.3 - What regulations apply to this program?

    Science.gov (United States)

    2010-07-01

    ... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION PREPARING TOMORROW'S TEACHERS TO USE TECHNOLOGY § 614.3 What... Technology: (a) The Education Department General Administrative Regulations (EDGAR) as follows: (1) 34 CFR... 34 Education 3 2010-07-01 2010-07-01 false What regulations apply to this program? 614.3 Section...

  8. 34 CFR 660.4 - What definitions apply to the International Research and Studies Program?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What definitions apply to the International Research and Studies Program? 660.4 Section 660.4 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION THE INTERNATIONAL RESEARCH...

  9. 34 CFR 658.2 - Who is eligible to apply for assistance under this program?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Who is eligible to apply for assistance under this program? 658.2 Section 658.2 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION UNDERGRADUATE INTERNATIONAL STUDIES...

  10. 34 CFR 380.21 - What information requirement applies to this program?

    Science.gov (United States)

    2010-07-01

    ... TECHNICAL ASSISTANCE PROJECTS What Post-Award Conditions Must Be Met by a Grantee? § 380.21 What information requirement applies to this program? Each grantee must advise recipients of services under its project or, as...) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION SPECIAL PROJECTS AND...

  11. 15 CFR 20.2 - Programs or activities to which these regulations apply.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Programs or activities to which these regulations apply. 20.2 Section 20.2 Commerce and Foreign Trade Office of the Secretary of Commerce... adopted by an elected, general purpose legislative body which: (i) Provides benefits or assistance to...

  12. 42 CFR 65a.1 - To what programs do these regulations apply?

    Science.gov (United States)

    2010-10-01

    ... (see parts 63 and 64a of this chapter), or (4) Research training support under the NIH AIDS Research..., INTERNSHIPS, TRAINING NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES HAZARDOUS SUBSTANCES BASIC RESEARCH... part apply to the award of grants to support programs for basic research and training directed towards...

  13. 34 CFR 356.3 - What regulations apply to this program?

    Science.gov (United States)

    2010-07-01

    ... SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION DISABILITY AND REHABILITATION... purposefully requires inclusion of children with disabilities or individuals with mental disabilities as... 34 Education 2 2010-07-01 2010-07-01 false What regulations apply to this program? 356.3 Section...

  14. Applied Behavior Analysis Programs for Autism: Sibling Psychosocial Adjustment during and Following Intervention Use

    Science.gov (United States)

    Cebula, Katie R.

    2012-01-01

    Psychosocial adjustment in siblings of children with autism whose families were using a home-based, applied behavior analysis (ABA) program was compared to that of siblings in families who were not using any intensive autism intervention. Data gathered from parents, siblings and teachers indicated that siblings in ABA families experienced neither…

  15. 78 FR 32663 - Medicare Program; Notification of Closure of Teaching Hospitals and Opportunity To Apply for...

    Science.gov (United States)

    2013-05-31

    ...] Medicare Program; Notification of Closure of Teaching Hospitals and Opportunity To Apply for Available... announces the closure of two teaching hospitals and the initiation of an application process where hospitals... modifying language at section 1886(d)(5)(B)(v) of the Act, to instruct the Secretary to establish a process...

  16. Applied research in the ININ, solutions to challenges traced by the National Development Program

    International Nuclear Information System (INIS)

    Balcazar, M.

    1991-05-01

    The National Program of Development 1991-1994 and the necessities expressed by the society as regards Energy, Ecology, Feeding, Industry and Health, they outline problems of inevitable solution. This articulates it presents the contribution to the solution of some of these problems that the investigators associated to the Management of Applied Investigation of the Inn provide by means of specific projects. (Author)

  17. The applied research program of the High Flux Neutron Generator at the National Nuclear Center, Havana

    International Nuclear Information System (INIS)

    Perez, G.; Martin, G.; Ceballos, C.; Padron, I.; Shtejer, K.; Perez, N.; Guibert, R.; Ledo, L.M.; Cruz Inclan, Carlos

    2001-01-01

    The Havana High Flux Neutron Generator facility is an intense neutron source based on a 20 mA duoplasmatron ion source and a 250 kV high voltage power supply. It has been installed in the Neutron Generator Laboratory at the Center of Applied Technologies and Nuclear Research in 1997. This paper deal outlined the future applied program to be carried out in this facility in the next years. The Applied Research Program consists on install two nuclear analytic techniques: the PELAN technique which uses the neutron generator in the pulse mode and the Low Energy PIXE technique which uses the same facility as a low energy proton accelerator for PIXE analysis. (author)

  18. CLUST-applied program package for solution of radiation problems in solid-state physics

    International Nuclear Information System (INIS)

    Sidorenko, A.D.

    1983-01-01

    A general structure is outlined of the CLUST applied program package for a system of equations describing nucleation and growth of dislocation loops and vacancies in metal exposed to a fast particle flux. The CLUST package represents a set of programs for solving the systems of ordinary differential equations of special type with entering the count results into the file. The count process is controlled by a special monitor, which essentially facilitates the user program checkout and increases the efficiency of using computer time. The output of the results and scanning of the file can be realized through the analog-digital printing device or the terminal. The package structure enables the programs to be easily rearranged for solving other problems with the total number of variables 500. Operation with the package in the BEhSM-6 computer is described and principles of package rearrangement are presented

  19. Cameco engineered tailings program: linking applied research with industrial processes for improved tailings performance

    International Nuclear Information System (INIS)

    Kotzer, T.G.

    2010-01-01

    'Full text:' Mine tailings at Cameco's operations are by-products of milling uranium ore having variable concentrations of uranium, metals, oxyanions and trace elements or elements of concern (EOC). Cameco has undertaken an Engineered Tailings (ET) program to optimize tailings performance and minimize environmental EOC impacts, regardless of the milled ore source. Applied geochemical and geotechnical tailings research is key within the ET program. In-situ drilling and experimental programs are used to understand long-term tailings behaviour and help validate source term predictions. Within this, the ET program proactively aids in the development of mill-based processes for production of tailings having improved long-term stability. (author)

  20. NASA Applied Sciences' DEVELOP National Program: Training the Next Generation of Remote Sensing Scientists

    Science.gov (United States)

    Childs, Lauren; Brozen, Madeline; Hillyer, Nelson

    2010-01-01

    Since its inception over a decade ago, the DEVELOP National Program has provided students with experience in utilizing and integrating satellite remote sensing data into real world-applications. In 1998, DEVELOP began with three students and has evolved into a nationwide internship program with over 200 students participating each year. DEVELOP is a NASA Applied Sciences training and development program extending NASA Earth science research and technology to society. Part of the NASA Science Mission Directorate s Earth Science Division, the Applied Sciences Program focuses on bridging the gap between NASA technology and the public by conducting projects that innovatively use NASA Earth science resources to research environmental issues. Project outcomes focus on assisting communities to better understand environmental change over time. This is accomplished through research with global, national, and regional partners to identify the widest array of practical uses of NASA data. DEVELOP students conduct research in areas that examine how NASA science can better serve society. Projects focus on practical applications of NASA s Earth science research results. Each project is designed to address at least one of the Applied Sciences focus areas, use NASA s Earth observation sources and meet partners needs. DEVELOP research teams partner with end-users and organizations who use project results for policy analysis and decision support, thereby extending the benefits of NASA science and technology to the public.

  1. Semiconductor band alignment from first principles: a new nonequilibrium Green's function method applied to the CZTSe/CdS interface for photovoltaics

    DEFF Research Database (Denmark)

    Palsgaard, Mattias Lau Nøhr; Crovetto, Andrea; Gunst, Tue

    2016-01-01

    In this paper we present a method to obtain the band offset of semiconductor heterointerfaces from Density Functional Theory together with the nonequilibrium Green's function method. Band alignment and detailed properties of the interface between Cu2ZnSnSe4 and CdS are extracted directly from first...... principles simulations. The interface is important for photovoltaics applications where in particular the band offsets are important for efficiency. The band bending pose a problem for accurate atomistic simulations of band offsets due to its long range. Here we investigate two different methods for dealing...... with band bending directly. One involves doping the materials to induce a shorter screening length. The other method is to apply a voltage bias across the interface to correct for the band bending. The calculated band offsets agree well with previous experimental and theoretical studies and, interestingly...

  2. Mozambique field epidemiology and laboratory training program: a pathway for strengthening human resources in applied epidemiology.

    Science.gov (United States)

    Baltazar, Cynthia Semá; Taibo, Cátia; Sacarlal, Jahit; Gujral, Lorna; Salomão, Cristolde; Doyle, Timothy

    2017-01-01

    In the last decades, Mozambique has been undergoing demographic, epidemiological, economic and social transitions, which have all had a notable impact on the National Health System. New challenges have emerged, causing a need to expand the preparation and response to emerging disease threats and public health emergencies. We describe the structure and function of the Mozambique Field Epidemiology Training Program (MZ-FELTP) and the main outputs achieved during the first 6 years of program implementation (consisting of 3 cohorts). We also outline the contribution of the program to the National Health System and assess the retention of the graduates. The MZ-FELTP is a post-graduate in-service training program, based on the acquisition of skills, within two tracks: applied epidemiology and laboratory management. The program was established in 2010, with the objective of strengthening capacity in applied epidemiology and laboratory management, so that events of public health importance can be detected and investigated in a timely and effective manner. The program is in its seventh year, having successfully trained 36 health professionals in the advanced course. During the first six years of the program, more than 40 outbreaks were investigated, 37 surveillance system evaluations were conducted and 39 descriptive data analyses were performed. Surveillance activities were implemented for mass events and emergency situations. In addition, more than 100 oral and poster presentations were given by trainees at national and international conferences. The MZ-FELTP has helped provide the Ministry of Health with the human and technical resources and operational capacity, to rapidly and effectively respond to major public health challenges in the country. The continuous involvement of key stakeholders is necessary for the continuation, expansion and ongoing sustainability of the program.

  3. 34 CFR 658.4 - What definitions apply to the Undergraduate International Studies and Foreign Language Program?

    Science.gov (United States)

    2010-07-01

    ... International Studies and Foreign Language Program? 658.4 Section 658.4 Education Regulations of the Offices of... UNDERGRADUATE INTERNATIONAL STUDIES AND FOREIGN LANGUAGE PROGRAM General § 658.4 What definitions apply to the Undergraduate International Studies and Foreign Language Program? The definitions in 34 CFR 655.4 apply to this...

  4. 34 CFR 403.63 - How does a State carry out the State Vocational and Applied Technology Education Program?

    Science.gov (United States)

    2010-07-01

    ... Applied Technology Education Program? 403.63 Section 403.63 Education Regulations of the Offices of the... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAM What Kinds of Activities Does the Secretary Assist Under... Technology Education Program? (a) Unless otherwise indicated in the regulations in this part, a State board...

  5. 45 CFR 660.6 - What procedures apply to the selection of programs and activities under these regulations?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false What procedures apply to the selection of programs... Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION INTERGOVERNMENTAL REVIEW OF THE NATIONAL SCIENCE FOUNDATION PROGRAMS AND ACTIVITIES § 660.6 What procedures apply to the selection of programs and activities...

  6. The therapeutic CD38 monoclonal antibody daratumumab induces programmed cell death via fcg receptor-mediated cross-linking

    DEFF Research Database (Denmark)

    Overdijk, Marije B.; Jansen, J. H. Marco; Nederend, Maaike

    2016-01-01

    RIIb as well as activating FcgRs induce DARA cross-linking-mediated PCD. In conclusion, our in vitro and in vivo data show that FcgRmediated cross-linking of DARA induces PCD of CD38-expressing multiple myeloma tumor cells, which potentially contributes to the depth of response observed in DARA......Emerging evidence suggests that FcgR-mediated cross-linking of tumor-bound mAbs may induce signaling in tumor cells that contributes to their therapeutic activity. In this study, we show that daratumumab (DARA), a therapeutic human CD38 mAb with a broad-spectrum killing activity, is able to induce...... programmed cell death (PCD) of CD38+ multiple myeloma tumor cell lines when cross-linked in vitro by secondary Abs or via an FcgR. By comparing DARA efficacy in a syngeneic in vivo tumor model using FcRg-chain knockout or NOTAM mice carrying a signaling-inactive FcRg-chain, we found that the inhibitory Fcg...

  7. Cancer vaccine enhanced, non-tumor-reactive CD8(+) T cells exhibit a distinct molecular program associated with "division arrest anergy".

    Science.gov (United States)

    Beyer, Marc; Karbach, Julia; Mallmann, Michael R; Zander, Thomas; Eggle, Daniela; Classen, Sabine; Debey-Pascher, Svenja; Famulok, Michael; Jäger, Elke; Schultze, Joachim L

    2009-05-15

    Immune-mediated tumor rejection relies on fully functional T-cell responses and neutralization of an adverse tumor microenvironment. In clinical trials, we detected peptide-specific but non-tumor-reactive and therefore not fully functional CD8(+) T cells post-vaccination against tumor antigens. Understanding the molecular mechanisms behind nontumor reactivity will be a prerequisite to overcome this CD8(+) T-cell deviation. We report that these non-tumor-reactive CD8(+) T cells are characterized by a molecular program associated with hallmarks of "division arrest anergy." Non-tumor-reactive CD8(+) T cells are characterized by coexpression of CD7, CD25, and CD69 as well as elevated levels of lck(p505) and p27(kip1). In vivo quantification revealed high prevalence of non-tumor-reactive CD8(+) T cells with increased levels during cancer vaccination. Furthermore, their presence was associated with a trend toward shorter survival. Dynamics and frequencies of non-target-reactive CD8(+) T cells need to be further addressed in context of therapeutic vaccine development in cancer, chronic infections, and autoimmune diseases.

  8. Successes and Challenges in the SAGE (Summer of Applied Geophysical Experience) REU Program

    Science.gov (United States)

    Braile, L. W.; Baldridge, W. S.; Pellerin, L.; Ferguson, J. F.; Bedrosian, P.; Biehler, S.; Jiracek, G. R.; Snelson, C. M.; Kelley, S.; McPhee, D.

    2014-12-01

    The SAGE program was initiated in 1983 to provide an applied geophysics research and education experience for students. Since 1983, 820 students have completed the SAGE summer program. Beginning in 1992, with funding from the NSF, SAGE has included an REU (Research Experience for Undergraduates) experience for selected undergraduate students from U.S. colleges and universities. Since 1992, 380 undergraduate REU students have completed the SAGE program. The four week, intensive, summer program is based in Santa Fe, New Mexico, and involves students in learning geophysical theory and applications; collection of geophysical field data in the northern Rio Grande Rift area; data processing, modeling and interpretation; and presentation (oral and written) of results of each student's research results. Students (undergraduates, graduates and professionals) and faculty are together on a school campus for the summer program. Successful strategies (developed over the years) of the program include teamwork experience, mentoring of REUs (by faculty and more senior students), cultural interchange due to students from many campuses across the U.S. and international graduate students, including industry visitors who work with the students and provide networking, a capstone experience of the summer program that includes all students making a "professional-meeting" style presentation of their research and submitting a written report, a follow-up workshop for the REU students to enhance and broaden their experience, and providing professional development for the REUs through oral or poster presentations and attendance at a professional meeting. Program challenges include obtaining funding from multiple sources; significant time investment in program management, reporting, and maintaining contact with our many funding sources and industry affiliates; and, despite significant efforts, limited success in recruiting racial and ethnic minority students to the program.

  9. The ITER EC H and CD Upper Launcher: Analysis of vertical Remote Handling applied to the BSM maintenance

    International Nuclear Information System (INIS)

    Grossetti, Giovanni; Aiello, Gaetano; Heemskerk, Cock; Elzendoorn, Ben; Geßner, Robby; Koning, Jarich; Meier, Andreas; Ronden, Dennis; Späh, Peter; Scherer, Theo; Schreck, Sabine; Strauß, Dirk; Vaccaro, Alessandro

    2013-01-01

    This paper deals with Remote Handling activities foreseen on the Blanket Shield Module, the plasma facing component of the ITER Electron Cyclotron Heating and Current Drive Upper Launcher. The maintenance configuration considered here is the Vertical Remote Handling, meaning gravity acting along the launcher radial axis. The plant, where the maintenance under consideration is occurring, is the Hot Cell Facility Work Cell. The study here reported has been carried out within the presently ongoing EFDA Goal Oriented Training program on Remote Handling (GOT-RH), which aims to support ITER activities. This document and its contents have to be considered as part of a more vast RAMI analysis to be developed within the GOT-RH, which aims to maximize the Electron Cyclotron Heating and Current Drive system availability. The Baseline CAD model of the Electron Cyclotron Heating and Current Drive Upper Launcher is currently in its preliminary design phase and does not provide enough details for developing a fully detailed maintenance strategy. Therefore, through a System Engineering approach, a set of assumptions was conceived on the launcher structure, as a basis for development of a Remote Handling strategy. Moreover, to compare different design solutions related to the possibility of integrating a quasi-optical component into the Blanket Shield Module, a Trade-Off was made, and its contents are shown here. The outcome of this System Engineering approach has been formalized into Task Definition Forms whose contents are reported here. The Remote Handling strategy presented in this work will be tested in the near future both through Virtual Reality simulations and through prototype experiments

  10. The ITER EC H and CD Upper Launcher: Analysis of vertical Remote Handling applied to the BSM maintenance

    Energy Technology Data Exchange (ETDEWEB)

    Grossetti, Giovanni, E-mail: giovanni.grossetti@kit.edu [Karlsruhe Institute of Technology, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany); Aiello, Gaetano [Karlsruhe Institute of Technology, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany); Heemskerk, Cock [Heemskerk Innovative Technology, Merelhof 2, 2172 HZ Sassenheim (Netherlands); Elzendoorn, Ben [FOM Institute DIFFER, P.O. Box 1207, 3430 BE Nieuwegein (Netherlands); Geßner, Robby [Karlsruhe Institute of Technology, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany); Koning, Jarich [Heemskerk Innovative Technology, Merelhof 2, 2172 HZ Sassenheim (Netherlands); Meier, Andreas [Karlsruhe Institute of Technology, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany); Ronden, Dennis [FOM Institute DIFFER, P.O. Box 1207, 3430 BE Nieuwegein (Netherlands); Späh, Peter; Scherer, Theo; Schreck, Sabine; Strauß, Dirk; Vaccaro, Alessandro [Karlsruhe Institute of Technology, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany)

    2013-10-15

    This paper deals with Remote Handling activities foreseen on the Blanket Shield Module, the plasma facing component of the ITER Electron Cyclotron Heating and Current Drive Upper Launcher. The maintenance configuration considered here is the Vertical Remote Handling, meaning gravity acting along the launcher radial axis. The plant, where the maintenance under consideration is occurring, is the Hot Cell Facility Work Cell. The study here reported has been carried out within the presently ongoing EFDA Goal Oriented Training program on Remote Handling (GOT-RH), which aims to support ITER activities. This document and its contents have to be considered as part of a more vast RAMI analysis to be developed within the GOT-RH, which aims to maximize the Electron Cyclotron Heating and Current Drive system availability. The Baseline CAD model of the Electron Cyclotron Heating and Current Drive Upper Launcher is currently in its preliminary design phase and does not provide enough details for developing a fully detailed maintenance strategy. Therefore, through a System Engineering approach, a set of assumptions was conceived on the launcher structure, as a basis for development of a Remote Handling strategy. Moreover, to compare different design solutions related to the possibility of integrating a quasi-optical component into the Blanket Shield Module, a Trade-Off was made, and its contents are shown here. The outcome of this System Engineering approach has been formalized into Task Definition Forms whose contents are reported here. The Remote Handling strategy presented in this work will be tested in the near future both through Virtual Reality simulations and through prototype experiments.

  11. Applied electro-optics educational and training program with multiple entrance and exit pathways

    Science.gov (United States)

    Scott, Patricia; Zhou, Feng; Zilic, Dorothy

    2007-06-01

    This paper presents an innovative hands-on training program designed to create a pipeline of highly-skilled technical workers for today's workforce economy. The 2+2+2 Pennsylvania Integrated Workforce Leadership Program in Electro-Optics prepares students for a career in this new high-tech field. With seamless transition from high school into college, the program offers the versatility of multiple entrance and exit pathways. After completion of each educational level, students can exit the program with various skill levels, including certificates, an associate's degree, or a bachelor's degree. Launched by Indiana University of Pennsylvania (IUP) in partnership with Lenape Vocational School (Lenape), the 2+2+2 educational pathway program was implemented to promote early training of high-school students. During the first level, students in their junior and/or senior year enroll in four Electro-Optics courses at Lenape. Upon completion of these courses and an Advanced Placement Equivalency course with an appropriate exam score, students can earn a certificate from Lenape for the 15+ credits, which also can be articulated into IUP's associate degree program in Electro-Optics. During the second level, students can earn an associate's degree in Electro-Optics, offered only at the IUP Northpointe Campus. After completion of the Associate in Applied Science (A.A.S.), students are prepared to enter the workforce as senior technicians. During the third level, students who have completed the Associate of Science (A.S.) in Electro-Optics have the opportunity to matriculate at IUP's Indiana Campus to earn a Bachelor of Science (B.S.) degree in Applied Physics with a track in Electro-Optics. Hence, the name 2+2+2 refers to getting started in high school, continuing the educational experience with an associate's degree program, and optionally moving on to a bachelor's degree. Consequently, students move from one educational level to the next with advanced credits toward the next

  12. The Impact of Planning on the Quality of Educational Programs at Al- Balqa' Applied University

    OpenAIRE

    Hamdan Salim Alawamleh; Ahmed Bdah; Nidal Alahmad

    2013-01-01

    The aim of the study is to investigate the impact of planning on the quality of educational programs at Al- Balqa' Applied University from the perspective of the faculty members and heads of academic departments and deans and their assistants and their deputies in order to detect whether if there is a significance statistical differences due to the variables (Sex, qualification, years of experience, the functional level), after the statement of the correlation between the variables of the stu...

  13. Sharing NASA Science with Decision Makers: A Perspective from NASA's Applied Remote Sensing Training (ARSET) Program

    Science.gov (United States)

    Prados, A. I.; Blevins, B.; Hook, E.

    2015-12-01

    NASA ARSET http://arset.gsfc.nasa.gov has been providing applied remote sensing training since 2008. The goals of the program are to develop the technical and analytical skills necessary to utilize NASA resources for decision-support. The program has reached over 3500 participants, with 1600 stakeholders from 100 countries in 2015 alone. The target audience for the program are professionals engaged in environmental management in the public and private sectors, such as air quality forecasters, public utilities, water managers and non-governmental organizations engaged in conservation. Many program participants have little or no expertise in NASA remote sensing, and it's frequently their very first exposure to NASA's vast resources. One the key challenges for the program has been the evolution and refinement of its approach to communicating NASA data access, research, and ultimately its value to stakeholders. We discuss ARSET's best practices for sharing NASA science, which include 1) training ARSET staff and other NASA scientists on methods for science communication, 2) communicating the proper amount of scientific information at a level that is commensurate with the technical skills of program participants, 3) communicating the benefit of NASA resources to stakeholders, and 4) getting to know the audience and tailoring the message so that science information is conveyed within the context of agencies' unique environmental challenges.

  14. Applying health education theory to patient safety programs: three case studies.

    Science.gov (United States)

    Gilkey, Melissa B; Earp, Jo Anne L; French, Elizabeth A

    2008-04-01

    Program planning for patient safety is challenging because intervention-oriented surveillance data are not yet widely available to those working in this nascent field. Even so, health educators are uniquely positioned to contribute to patient safety intervention efforts because their theoretical training provides them with a guide for designing and implementing prevention programs. This article demonstrates the utility of applying health education concepts from three prominent patient safety campaigns, including the concepts of risk perception, community participation, and social marketing. The application of these theoretical concepts to patient safety programs suggests that health educators possess a knowledge base and skill set highly relevant to patient safety and that their perspective should be increasingly brought to bear on the design and evaluation of interventions that aim to protect patients from preventable medical error.

  15. Inside the "Black Box" of a Knowledge Translation Program in Applied Health Research.

    Science.gov (United States)

    Heaton, Janet; Day, Jo; Britten, Nicky

    2015-11-01

    In this article, we present the findings of a participatory realistic evaluation of a 5-year program of health care research intended to promote the translation of knowledge into routine clinical practice. The program was one of the nine pilot Collaborations for Leadership in Applied Health Research and Care funded by the English National Institute for Health Research between 2008 and 2013. Our aim was to delineate the mechanisms by which, and circumstances in which, some projects carried out under the program achieved success in knowledge translation while others were frustrated. Using qualitative methods, we examined how closer collaboration between academics and clinicians worked in four purposefully chosen case studies. In a synthesis of the findings, we produced a "black box" model of how knowledge translation was enabled by the activation of nine mechanisms. These are summarized in the form of five simple rules for promoting knowledge translation through collaborations based on principles of coproduction. © The Author(s) 2015.

  16. The Applied Meteorology Unit: Nineteen Years Successfully Transitioning Research Into Operations for America's Space Program

    Science.gov (United States)

    Madura, John T.; Bauman, William H., III; Merceret, Francis J.; Roeder, William P.; Brody, Frank C.; Hagemeyer, Bartlett C.

    2011-01-01

    The Applied Meteorology Unit (AMU) provides technology development and transition services to improve operational weather support to America's space program . The AMU was founded in 1991 and operates under a triagency Memorandum of Understanding (MOU) between the National Aeronautics and Space Administration (NASA), the United States Air Force (USAF) and the National Weather Service (NWS) (Ernst and Merceret, 1995). It is colocated with the 45th Weather Squadron (45WS) at Cape Canaveral Air Force Station (CCAFS) and funded by the Space Shuttle Program . Its primary customers are the 45WS, the Spaceflight Meteorology Group (SMG) operated for NASA by the NWS at the Johnson Space Center (JSC) in Houston, TX, and the NWS forecast office in Melbourne, FL (MLB). The gap between research and operations is well known. All too frequently, the process of transitioning research to operations fails for various reasons. The mission of the AMU is in essence to bridge this gap for America's space program.

  17. Evaluation model applied to TRANSPETRO's Marine Terminals Standardization Program

    Energy Technology Data Exchange (ETDEWEB)

    Almeida, Maria Fatima Ludovico de; Mueller, Gabriela [Pontificia Universidade Catolica do Rio de Janeiro (PUC-Rio), Rio de Janeiro, RJ (Brazil). Instituto Tecnologico; Garcia, Luciano Maldonado [TRANSPETRO - PETROBRAS Transporte S.A., Rio de Janeiro, RJ (Brazil)

    2009-07-01

    This paper describes an innovative evaluation model applied to TRANSPETRO's 'Marine Terminals Standardization Program' based on updating approaches of programs evaluation and organizational learning. Since the program was launched in 2004, the need for having an evaluation model able to evaluate its implementation progress, to measure the degree of standards compliance and its potential economic, social and environmental impacts has become evident. Within a vision of safe and environmentally responsible operations of marine terminals, this evaluation model was jointly designed by TRANSPETRO and PUC-Rio to promote continuous improvement and learning in operational practices and in the standardization process itself. TRANSPETRO believes that standardization supports its services and management innovation capability by creating objective and internationally recognized parameters, targets and metrology for its business activities. The conceptual model and application guidelines for this important tool are presented in this paper, as well as the next steps towards its implementation. (author)

  18. [Effect of Smartphone Apps Applying BodyThink Program on Obesity in Adolescent Girls].

    Science.gov (United States)

    Jun, Min Kyung; Ha, Ju Young

    2016-06-01

    The purpose of this study was to determine the effects of smartphone apps applying BodyThink program on BMI, percentage of body fat, skeletal muscle rate, body image, and self-esteem of adolescent girls. Sixty-eight high school girls with a BMI of over 25kg/m² were recruited to participate in this study. Girls from four schools were divided into two groups: the experimental group, which used the smartphone apps applying BodyThink program, and the control group, which used smartphone apps and small group counseling. The experimental group received the BodyThink program 6 times, scheduled once a week, with each session lasting 40~50 minutes. Test measures were completed before and after the 6 week intervention period for all participants. Collected data was analyzed using Shapiro-Wilk test, descriptive statistics, χ² test, independent t-test, Mann-Whitney U test with the SPSS/WIN 18.0 program. The girls in the experimental group significantly improved their results in BMI(Z=-1.67, p=.042), percentage of body fat (Z=-3.01, p=.001), skeletal muscle rate (t=-3.50, peffective alternative methods to improve the body composition and self-esteem of obese adolescent girls.

  19. Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment? Epigenome: A Dynamic Vehicle for Transmitting and Recording Cytokine Signaling.

    Science.gov (United States)

    Johnson, John L; Vahedi, Golnaz

    2018-03-01

    CD4 + T cells are critical for the elimination of an immense array of microbial pathogens. Although there are aspects of helper T-cell differentiation that can be modeled as a classic cell-fate commitment, CD4 + T cells also maintain considerable flexibility in their transcriptional program. Here, we present an overview of chromatin biology during cellular reprogramming and, within this context, envision how the scope of cellular reprogramming may be expanded to further our understanding of the controversy surrounding CD4 + T lymphocyte plasticity or determinism. Copyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved.

  20. Optimization programs of radiation protection applied to post-graduation and encouraging research

    International Nuclear Information System (INIS)

    Levy, Denise S.; Sordi, Gian Maria A.A.

    2013-01-01

    In 2011 we started the automation and integration of radiological protection optimization programs, in order to offer unified programs and inter-related information in Portuguese, providing Brazilian radioactive facilities a complete repository for research, consultation and information. The authors of this project extended it to postgraduate education, in order to encourage postgraduate students researches, expanding methods for enhancing student learning through the use of different combined resources, such as educational technology, information technology and group dynamics. This new methodology was applied in a postgraduate discipline at Instituto de Pesquisas Energeticas e Nucleares (IPEN), Brazil, in the postgraduate discipline entitled Fundamental Elements of Radiological Protection (TNA-5732). Students have six weeks to assimilate a complex content of optimization, considering national and international standards, guidelines and recommendations published by different organizations over the past decades. Unlike traditional classes, in which students receive prompt responses, this new methodology stimulates discussion, encouraging collective thinking processes and promoting ongoing personal reflection and researches. Case-oriented problem-solving permitted students to play different roles, promoting whole-group discussions and cooperative learning, approaching theory and practical applications. Students discussed different papers, published in international conferences, and their implications according to current standards. The automation of optimization programs was essential as a research tool during the course. The results of this experience were evaluated in two consecutive years. We had excellent results compared to the previous 14 years. The methodology has exceeded expectations and will be also applied in 2013 to ionizing radiation monitoring postgraduate classes. (author)

  1. 34 CFR 661.2 - Who is eligible to apply for a grant under the Business and International Education Program?

    Science.gov (United States)

    2010-07-01

    ... INTERNATIONAL EDUCATION PROGRAM General § 661.2 Who is eligible to apply for a grant under the Business and... 34 Education 3 2010-07-01 2010-07-01 false Who is eligible to apply for a grant under the Business and International Education Program? 661.2 Section 661.2 Education Regulations of the Offices of the...

  2. 45 CFR 1351.11 - Who is eligible to apply for a Runaway and Homeless Youth Program grant?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Who is eligible to apply for a Runaway and... FOR CHILDREN, YOUTH AND FAMILIES, FAMILY AND YOUTH SERVICES BUREAU RUNAWAY AND HOMELESS YOUTH PROGRAM Runaway and Homeless Youth Program Grant § 1351.11 Who is eligible to apply for a Runaway and Homeless...

  3. Programmed Death-1 expression on Epstein Barr virus specific CD8+ T cells varies by stage of infection, epitope specificity, and T-cell receptor usage.

    Directory of Open Access Journals (Sweden)

    Thomas C Greenough

    Full Text Available BACKGROUND: Programmed Death-1 (PD-1 is an inhibitory member of the CD28 family of molecules expressed on CD8+ T cells in response to antigenic stimulation. To better understand the role of PD-1 in antiviral immunity we examined the expression of PD-1 on Epstein-Barr virus (EBV epitope-specific CD8+ T cells during acute infectious mononucleosis (AIM and convalescence. METHODOLOGY/PRINCIPAL FINDINGS: Using flow cytometry, we observed higher frequencies of EBV-specific CD8+ T cells and higher intensity of PD-1 expression on EBV-specific CD8+ T cells during AIM than during convalescence. PD-1 expression during AIM directly correlated with viral load and with the subsequent degree of CD8+ T cell contraction in convalescence. Consistent differences in PD-1 expression were observed between CD8+ T cells with specificity for two different EBV lytic antigen epitopes. Similar differences were observed in the degree to which PD-1 was upregulated on these epitope-specific CD8+ T cells following peptide stimulation in vitro. EBV epitope-specific CD8+ T cell proliferative responses to peptide stimulation were diminished during AIM regardless of PD-1 expression and were unaffected by blocking PD-1 interactions with PD-L1. Significant variability in PD-1 expression was observed on EBV epitope-specific CD8+ T cell subsets defined by V-beta usage. CONCLUSIONS/SIGNIFICANCE: These observations suggest that PD-1 expression is not only dependent on the degree of antigen presentation, but also on undefined characteristics of the responding cell that segregate with epitope specificity and V-beta usage.

  4. NASA Applied Sciences Program. Overview Presentation; Discovering and Demonstrating Innovative and Practical Applications of Earth Science

    Science.gov (United States)

    Irwin, Daniel

    2010-01-01

    Goal 1: Enhance Applications Research Advance the use of NASA Earth science in policy making, resource management and planning, and disaster response. Key Actions: Identify priority needs, conduct applied research to generate innovative applications, and support projects that demonstrate uses of NASA Earth science. Goal 2: Increase Collaboration Establish a flexible program structure to meet diverse partner needs and applications objectives. Key Actions: Pursue partnerships to leverage resources and risks and extend the program s reach and impact. Goal 3:Accelerate Applications Ensure that NASA s flight missions plan for and support applications goals in conjunction with their science goals, starting with mission planning and extending through the mission life cycle. Key Actions: Enable identification of applications early in satellite mission lifecycle and facilitate effective ways to integrate end-user needs into satellite mission planning

  5. Applying Positive Deviance for Improving Compliance to Adolescent Anemia Control Program in Tribal Communities of India.

    Science.gov (United States)

    Sethi, Vani; Sternin, Monique; Sharma, Deepika; Bhanot, Arti; Mebrahtu, Saba

    2017-09-01

    Positive deviance (PD) is an asset-based social and behavior change communication strategy, utilizing successful outliers within a specific context. It has been applied to tackling major public health problems but not adolescent anemia. The study, first of its kind, used PD to improve compliance to adolescent anemia control program in Jharkhand, India, where anemia prevalence in adolescent girls is 70%, and program compliance is low. With leadership of state government, the study was designed and implemented by a multidisciplinary 42 member PD team, in Khunti district, in 2014. Participatory appraisals were undertaken with 434 adolescent girls, 18 frontline workers, 15 teachers, and 751 community leaders/parents/relatives. Stakeholders were interviewed to identify positive deviants and PD determinants across 17 villages. Perceived benefits of iron folic acid tablet and nutritional care during adolescence are low. Positive deviants exist among adolescent girls (26 of 434), villages (2 of 17), and schools (2 of 17). Positive deviant adolescent girls consumed variety of iron-rich foods and in higher frequency, consumed iron folic acid tablets, and practiced recommended personal hygiene behaviors. Deviant practices in schools included supervision of students during tablet distribution among others. Government-led PD approach uncovered local solutions and provided a forum for government functionaries to listen to and dialogue with, and an opportunity to adapt the program according to the needs of the affected communities, who are missing partners in program design and management.

  6. Fusion programs in applied plasma physics. Technical progress report, July 11, 1992--May 31, 1993

    Energy Technology Data Exchange (ETDEWEB)

    1993-07-01

    This report summarizes the progress made in theoretical and experimental research funded by US Department of Energy Grant No. DE-FG03-92ER54150, during the period July 11, 1992 through May 31, 1993. Four main tasks are reported: applied plasma physics theory, alpha particle diagnostic, edge and current density diagnostic, and plasma rotation drive. The report also discusses the research plans for the theory and experimental programs for the next grant year. Reports and publications supported by the grant during this period are listed in the final section.

  7. Technology Applied to ELT: Reviewing Practical Uses to Enhance English Teaching Programs

    Directory of Open Access Journals (Sweden)

    Javier Rojas Serrano

    2007-12-01

    Full Text Available In this paper, the author reports on some of the areas of technology currently used in the teaching and learning of languages, and reviews some of the uses of technological tools that are present in the English Adult Program and activities carried out at The Centro Colombo Americano (CCA in Bogota, Colombia. After briefly describing what is being applied worldwide in terms of what is being done at the CCA, some suggestions are offered in order to enhance the English teaching and learning processes through the use of new technologies.

  8. Brucellosis Prevention Program: Applying “Child to Family Health Education” Method

    Directory of Open Access Journals (Sweden)

    H. Allahverdipour

    2010-04-01

    Full Text Available Introduction & Objective: Pupils have efficient potential to increase community awareness and promoting community health through participating in the health education programs. Child to family health education program is one of the communicative strategies that was applied in this field trial study. Because of high prevalence of Brucellosis in Hamadan province, Iran, the aim of this study was promoting families’ knowledge and preventive behaviors about Brucellosis in the rural areas by using child to family health education method.Materials & Methods: In this nonequivalent control group design study three rural schools were chosen (one as intervention and two others as control. At first knowledge and behavior of families about Brucellosis were determined using a designed questionnaire. Then the families were educated through “child to family” procedure. At this stage the students gained information. Then they were instructed to teach their parents what they had learned. After 3 months following the last session of education, the level of knowledge and behavior changes of the families about Brucellosis were determined and analyzed by paired t-test.Results: The results showed significant improvement in the knowledge of the mothers. The knowledge of the mothers about the signs of Brucellosis disease in human increased from 1.81 to 3.79 ( t:-21.64 , sig:0.000 , and also the knowledge on the signs of Brucellosis in animals increased from 1.48 to 2.82 ( t:-10.60 , sig:0.000. Conclusion: Child to family health education program is one of the effective and available methods, which would be useful and effective in most communities, and also Students potential would be effective for applying in the health promotion programs.

  9. Effects of Reducing Antimicrobial Use and Applying a Cleaning and Disinfection Program in Veal Calf Farming: Experiences from an Intervention Study to Control Livestock-Associated MRSA.

    Directory of Open Access Journals (Sweden)

    Alejandro Dorado-García

    Full Text Available With the ultimate aim of containing the emergence of resistant bacteria, a Dutch policy was set in place in 2010 promoting a reduction of antimicrobial use (AMU in food-producing animals. In this context, a study evaluated strategies to curb livestock-associated methicillin resistant Staphylococcus aureus (LA-MRSA. Fifty-one veal calf farms were assigned to one of 3 study arms: RAB farms reducing antimicrobials by protocol; RAB-CD farms reducing antimicrobials by protocol and applying a cleaning and disinfection program; and Control farms without interventions. MRSA carriage was tested in week 0 and week 12 of 2 consecutive production cycles in farmers, family members and veal calves. Interventions were validated and a cyclic rise in MRSA-prevalence in animals was shown with a more moderate increase in RAB farms. Prevalence in humans declined parallel over time in the study arms but RAB farms were at the lowest MRSA levels from the beginning of the study. In RAB-CD farms, human and animal prevalence did not differ from Control farms and MRSA air loads were significantly higher than in the other study arms. Mimicking the national trend, an overall AMU decrease (daily dosages per animal per cycle (DDDA/C was observed over 4 pre-study and the 2 study cycles; this trend did not have a significant effect on a set of evaluated farm technical parameters. AMU was positively associated with MRSA across study arms (ORs per 10 DDDA/C increase = 1.26 for both humans (p = 0.07 and animals (p = 0.12 in first cycle. These results suggest that AMU reduction might be a good strategy for curbing MRSA in veal calf farming, however the specific cleaning and disinfecting program in RAB-CD farms was not effective. The drop in MRSA prevalence in people during the study could be attributed to the observed long-term AMU decreasing trend.

  10. Effects of Reducing Antimicrobial Use and Applying a Cleaning and Disinfection Program in Veal Calf Farming: Experiences from an Intervention Study to Control Livestock-Associated MRSA.

    Science.gov (United States)

    Dorado-García, Alejandro; Graveland, Haitske; Bos, Marian E H; Verstappen, Koen M; Van Cleef, Brigitte A G L; Kluytmans, Jan A J W; Wagenaar, Jaap A; Heederik, Dick J J

    2015-01-01

    With the ultimate aim of containing the emergence of resistant bacteria, a Dutch policy was set in place in 2010 promoting a reduction of antimicrobial use (AMU) in food-producing animals. In this context, a study evaluated strategies to curb livestock-associated methicillin resistant Staphylococcus aureus (LA-MRSA). Fifty-one veal calf farms were assigned to one of 3 study arms: RAB farms reducing antimicrobials by protocol; RAB-CD farms reducing antimicrobials by protocol and applying a cleaning and disinfection program; and Control farms without interventions. MRSA carriage was tested in week 0 and week 12 of 2 consecutive production cycles in farmers, family members and veal calves. Interventions were validated and a cyclic rise in MRSA-prevalence in animals was shown with a more moderate increase in RAB farms. Prevalence in humans declined parallel over time in the study arms but RAB farms were at the lowest MRSA levels from the beginning of the study. In RAB-CD farms, human and animal prevalence did not differ from Control farms and MRSA air loads were significantly higher than in the other study arms. Mimicking the national trend, an overall AMU decrease (daily dosages per animal per cycle (DDDA/C)) was observed over 4 pre-study and the 2 study cycles; this trend did not have a significant effect on a set of evaluated farm technical parameters. AMU was positively associated with MRSA across study arms (ORs per 10 DDDA/C increase = 1.26 for both humans (p = 0.07) and animals (p = 0.12 in first cycle)). These results suggest that AMU reduction might be a good strategy for curbing MRSA in veal calf farming, however the specific cleaning and disinfecting program in RAB-CD farms was not effective. The drop in MRSA prevalence in people during the study could be attributed to the observed long-term AMU decreasing trend.

  11. Social Justice Training in School Psychology: Applying Principles of Organizational Consultation to Facilitate Change in Graduate Programs

    Science.gov (United States)

    Grapin, Sally L.

    2017-01-01

    Scholars and professional organizations have called for an increased emphasis on social justice training in applied psychology graduate programs, including school psychology programs (SPPs). During the past decade, emerging research has identified some features of high-quality social justice education, including a clear program mission statement…

  12. 76 FR 78095 - Applying for Free and Reduced Price Meals in the National School Lunch Program and School...

    Science.gov (United States)

    2011-12-16

    ... 0584-AD54 [FNS-2007-0023] Applying for Free and Reduced Price Meals in the National School Lunch Program and School Breakfast Program and for Benefits in the Special Milk Program, and Technical... school meals to implement nondiscretionary provisions of the Child Nutrition and WIC Reauthorization Act...

  13. Summary and abstracts: Applied Research Units and Projects 1996 UCETF Program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-05-21

    The Urban Consortium (UC), created by PTI, is a network of jurisdictions with populations of over 250,000. The UC provides a platform for research and enterprise through its Energy, Environmental, Transportation, and Telecommunications and Information Task Forces. The UC provides a unique creative forum where elected and appointed officials and technical managers identify, test, and validate practical ways to improve the provision of public services and, where possible, generate new revenue opportunities. Public Technology, Inc., is the non-profit technology organization of the National League of Cities, the National Association of Counties, and the International City/County Management Association. PTI creates and advances technology-based products, services, and enterprises in cities and counties nationwide. Staffed by PTI, the UC addresses the critical needs of local governments through its Task Forces. The Urban Consortium Energy Task Force (UCETF) program has, since its inception, acted as a laboratory to develop, test solutions and share the resulting products or management approaches with the wider audience of local governments. It has addressed the overlap between energy and environment and economic development policy issues, and, is the nation's most extensive cooperative local government program to improve energy management and decision-making through applied research and technology cooperation. Proposals to meet the specific objectives of the UCETF annual R and D program are solicited from major urban jurisdictions. Projects based on these proposals are then selected by the UCETF for direct conduct and management by staff of city and county governments. Projects selected for each year's program are organized in thematic units to assure effective management and ongoing peer-to-peer experience exchange, with results documented at the end of each program year.

  14. Development of a Food Safety and Nutrition Education Program for Adolescents by Applying Social Cognitive Theory.

    Science.gov (United States)

    Lee, Jounghee; Jeong, Soyeon; Ko, Gyeongah; Park, Hyunshin; Ko, Youngsook

    2016-08-01

    The purpose of this study was to develop an educational model regarding food safety and nutrition. In particular, we aimed to develop educational materials, such as middle- and high-school textbooks, a teacher's guidebook, and school posters, by applying social cognitive theory. To develop a food safety and nutrition education program, we took into account diverse factors influencing an individual's behavior, such as personal, behavioral, and environmental factors, based on social cognitive theory. We also conducted a pilot study of the educational materials targeting middle-school students (n = 26), high-school students (n = 24), and dietitians (n = 13) regarding comprehension level, content, design, and quality by employing the 5-point Likert scale in May 2016. The food safety and nutrition education program covered six themes: (1) caffeine; (2) food additives; (3) foodborne illness; (4) nutrition and meal planning; (5) obesity and eating disorders; and (6) nutrition labeling. Each class activity was created to improve self-efficacy by setting one's own goal and to increase self-control by monitoring one's dietary intake. We also considered environmental factors by creating school posters and leaflets to educate teachers and parents. The overall evaluation score for the textbook was 4.0 points among middle- and high-school students, and 4.5 points among dietitians. This study provides a useful program model that could serve as a guide to develop educational materials for nutrition-related subjects in the curriculum. This program model was created to increase awareness of nutrition problems and self-efficacy. This program also helped to improve nutrition management skills and to promote a healthy eating environment in middle- and high-school students.

  15. Towson University's Professional Science Master's Program in Applied Physics: The first 5 years

    Science.gov (United States)

    Kolagani, Rajeswari

    It is a well-established fact that the scientific knowledge and skills acquired in the process of obtaining a degree in physics meet the needs of a variety of positions in multiple science and technology sectors. However, in addition to scientific competence, challenging careers often call for skills in advanced communication, leadership and team functions. The professional science master's degree, which has been nick-named as the `Science MBA', aims at providing science graduates an edge both in terms of employability and earning levels by imparting such skills. Our Professional Science Master's Program in Applied Physics is designed to develop these `plus' skills through multiple avenues. In addition to advanced courses in Applied Physics, the curriculum includes graduate courses in project management, business and technical writing, together with research and internship components. I will discuss our experience and lessons learned over the 5 years since the inception of the program in 2010. The author acknowledges support from the Elkins Professorship of the University System of Maryland.

  16. Comparative analysis of lockout programs and procedures applied to industrial machines

    Energy Technology Data Exchange (ETDEWEB)

    Chinniah, Y.; Champoux, M.; Burlet-Vienney, D.; Daigle, R. [Institut de recherche Robert-Sauve en sante et en securite du travail, Montreal, PQ (Canada)

    2008-09-15

    In 2005, approximately 20 workers in Quebec were killed by dangerous machines. Approximately 13,000 accidents in the province were linked to the use of machines. The resulting cost associated with these accidents was estimated to be $70 million to the Quebec Occupational Health and Safety Commission (CSST) in compensation and salary replacement. According to article 185 of the Quebec Occupational Health and Safety Regulation (RSST), workers intervening in hazardous zones of machines and processes during maintenance, repairs, and unjamming activities must apply lockout procedures. Lockout is defined as the placement of a lock or tag on an energy-isolating device in accordance with an established procedure, indicating that the energy-isolating device is not to be operated until removal of the lock or tag in accordance with an established procedure. This report presented a comparative analysis of lockout programs and procedures applied to industrial machines. The study attempted to answer several questions regarding the concept of lockout and its definition in the literature; the differences between legal lockout requirements among provinces and countries; different standards on lockout; the contents of lockout programs as described by different documents; and the compliance of lockout programs in a sample of industries in Quebec in terms of Canadian standard on lockout, the CSA Z460-05 (2005). The report discussed the research objectives, methodology, and results of the study. It was concluded that the concept of lockout has different meanings or definitions in the literature, especially in regulations. However, definitions of lockout which are found in standards have certain similarities. 50 refs., 52 tabs., 2 appendices.

  17. Rapid point-of-care CD4 testing at mobile HIV testing sites to increase linkage to care: an evaluation of a pilot program in South Africa.

    Science.gov (United States)

    Larson, Bruce A; Schnippel, Kathryn; Ndibongo, Buyiswa; Xulu, Thembisile; Brennan, Alana; Long, Lawrence; Fox, Matthew P; Rosen, Sydney

    2012-10-01

    A mobile HIV counseling and testing (HCT) program around Johannesburg piloted the integration of point-of-care (POC) CD4 testing, using the Pima analyzer, to improve linkages to HIV care. We report results from this pilot program for patients testing positive (n = 508) from May to October 2010. We analyzed 3 primary outcomes: assignment to testing group (offered POC CD4 or not), successful follow-up (by telephone), and completed the referral visit for HIV care within 8 weeks after HIV testing if successfully followed up. Proportions for each outcome were calculated, and relative risks were estimated using a modified Poisson approach. Three hundred eleven patients were offered the POC CD4 test, and 197 patients were not offered the test. No differences in patient characteristics were observed between the 2 groups. Approximately 62.7% of patients were successfully followed up 8 weeks after HIV testing, with no differences observed between testing groups. Among those followed up, 54.4% reported completing their referral visit. Patients offered the POC CD4 test were more likely to complete the referral visit for further HIV care (relative risk 1.25, 95% confidence interval: 1.00 to 1.57). In this mobile HCT setting, patients offered POC CD4 testing as part of the HCT services were more likely to visit a referral clinic after testing, suggesting that rapid CD4 testing technology may improve linkage to HIV care. Future research can evaluate options for adjusting HCT services if POC CD4 testing was included permanently and the cost-effectiveness of the POC CD4 testing compared with other approaches for improving linkage of care.

  18. Reactor physical experimental program EROS in the frame of the molten salt applying reactor concepts development

    International Nuclear Information System (INIS)

    Hron, Miloslav; Kyncl, Jan; Mikisek, Miroslav

    2009-01-01

    After the relatively broad program of experimental activities, which have been involved in the complex R and D program for the Molten Salt Reactor (MSR) - SPHINX (SPent Hot fuel Incinerator by Neutron fluX) concept development in the Czech Republic, there has been a next stage (namely large-scale experimental verification of design inputs by use of MSR-type inserted zones into the existing light water moderated experimental reactor LR-0 called EROS project) started, which will be focused to the experimental verification of the rector physical or neutronic properties of other types of reactor concepts applying molten salts in the role of liquid fuel and/or coolant. This tendency is based on the recently accepted decision of the MSR SSC of GIF to consider for further period of its activity two baseline concepts- fast neutron molten salt reactor non-moderated (FMSR-NM) as a long-term alternative to solid fuelled fast neutron reactors and simultaneously, advanced high temperature reactor (AHTR) with pebble bed type solid fuel cooled by liquid salts. There will be a brief description of the prepared and performed experimental programs in these directions (as well as the preliminary results obtained so far) introduced in the paper. (author)

  19. NEURO-FUZZY MODELING APPLIED IN PROGRAM MANAGEMENT TO INCREASE LOCAL PUBLIC ADMINISTRATION PERFORMANCE

    Directory of Open Access Journals (Sweden)

    Adrian-Mihai Zaharia-Radulescu

    2016-07-01

    Full Text Available One of the challenges in local public administration is dealing with an increasing number of competing requests coming from the communities they serve. The traditional approach would be to handle each request as a standalone project and be prioritized according to benefits and budget available. More and more nowadays program management is becoming a standard approach in managing the initiatives of local public administration. Program management approach is itself an enabler for performance in public sector organizations by allowing an organization to better coordinate its efforts and resources in managing a portfolio of projects. This paper aims to present how neuro-fuzzy modeling applied in program management can help an organization to increase its performance. Neuro-fuzzy modeling would lead organizations one step further by allowing them to simulate different scenarios and manage better the risks accompanying their initiatives. The research done by the authors is theoretical and combines knowledge from different areas and a neuro-fuzzy model is proposed and discussed.

  20. Summary of the Nevada Applied Ecology Group and correlative programs. Version 1

    Energy Technology Data Exchange (ETDEWEB)

    Friesen, H.N. [Raytheon Services Nevada, Las Vegas, NV (United States)

    1992-10-01

    This summary document presents results in a broad context; it is not limited to findings of the Nevada Applied Ecology Group. This book is organized to present the findings of the Nevada Applied Ecology Group and correlative programs in accordance with the originally stated objectives of the Nevada Applied Ecology Group. This plan, in essence, traces plutonium from its injection into the environment to movement in the ecosystem to development of cleanup techniques. Information on other radionuclides was also obtained and will be presented briefly. Chapter 1 presents a brief description of the ecological setting of the Test Range Complex. The results of investigations for plutonium distribution are presented in Chapter 2 for the area surrounding the Test Range Complex and in Chapter 3 for on-site locations. Chapters 4 and 5 present the results of investigations concerned with concentrations and movement, respectively, of plutonium in the ecosystem of the Test Range Complex, and Chapter 6 summarizes the potential hazard from this plutonium. Development of techniques for cleanup and treatment is presented in Chapter 7, and the inventory of radionuclides other than plutonium is presented briefly in Chapter 8.

  1. NASA Applied Sciences Disasters Program Support for the September 2017 Mexico Earthquakes

    Science.gov (United States)

    Glasscoe, M. T.; Kirschbaum, D.; Torres-Perez, J. L.; Yun, S. H.; Owen, S. E.; Hua, H.; Fielding, E. J.; Liang, C.; Bekaert, D. P.; Osmanoglu, B.; Amini, R.; Green, D. S.; Murray, J. J.; Stough, T.; Struve, J. C.; Seepersad, J.; Thompson, V.

    2017-12-01

    The 8 September M 8.1 Tehuantepec and 19 September M 7.1 Puebla earthquakes were among the largest earthquakes recorded in Mexico. These two events caused widespread damage, affecting several million people and causing numerous casualties. A team of event coordinators in the NASA Applied Sciences Program activated soon after these devastating earthquakes in order to support decision makers in Mexico, using NASA modeling and international remote sensing capabilities to generate decision support products to aid in response and recovery. The NASA Disasters Program promotes the use of Earth observations to improve the prediction of, preparation for, response to, and recovery from natural and technological disasters. For these two events, the Disasters Program worked with Mexico's space agency (Agencia Espacial Mexico, AEM) and the National Center for Prevention of Disasters (Centro Nacional de Prevención de Desastres, CENAPRED) to generate products to support response, decision-making, and recovery. Products were also provided to academic partners, technical institutions, and field responders to support response. In addition, the Program partnered with the US Geological Survey (USGS), Office of Foreign Disaster Assistance (OFDA), and other partners in order to provide information to federal and domestic agencies that were supporting event response. Leveraging the expertise of investigators at NASA Centers, products such as landslide susceptibility maps, precipitation models, and radar based damage assessments and surface deformation maps were generated and used by AEM, CENAPRED, and others during the event. These were used by AEM in collaboration with other government agencies in Mexico to make appropriate decisions for mapping damage, rescue and recovery, and informing the population regarding areas prone to potential risk. We will provide an overview of the response activities and data products generated in support of the earthquake response, partnerships with

  2. Possibility of choosing development investment programs of a production company by applying discounted investment appraisal technique

    Directory of Open Access Journals (Sweden)

    Vesić-Vasović Jasmina

    2014-01-01

    Full Text Available The selection of development investment programs is one of the most important decisions in industrial production. The paper sets out the possibilities of applying dynamic criteria for investment decision making. It presents a practical numerical example for the value calculation of investment criteria Net Present Value and Internal Rate of Return for the reviewed investment project solutions. In this manner it is possible to make an orderly set of alternatives with clear preferences for the most suitable alternative in comparison with other ones. Such rating of project solutions will enable the decision maker to emphasize advantages with more arguments and select the most suitable project solution in accordance with the established criteria, conditions and limitations.

  3. Applied behavior analysis programs for autism: sibling psychosocial adjustment during and following intervention use.

    Science.gov (United States)

    Cebula, Katie R

    2012-05-01

    Psychosocial adjustment in siblings of children with autism whose families were using a home-based, applied behavior analysis (ABA) program was compared to that of siblings in families who were not using any intensive autism intervention. Data gathered from parents, siblings and teachers indicated that siblings in ABA families experienced neither significant drawbacks nor benefits in terms of their behavioral adjustment, sibling relationship quality and self-concept compared to control group siblings, either during or following intervention use. Parents and siblings perceived improvements in sibling interaction since the outset of ABA, with parents somewhat more positive in their views than were siblings. Social support was associated with better sibling outcomes in all groups. Implications for supporting families using ABA are considered.

  4. Positive Mathematical Programming Approaches – Recent Developments in Literature and Applied Modelling

    Directory of Open Access Journals (Sweden)

    Thomas Heckelei

    2012-05-01

    Full Text Available This paper reviews and discusses the more recent literature and application of Positive Mathematical Programming in the context of agricultural supply models. Specifically, advances in the empirical foundation of parameter specifications as well as the economic rationalisation of PMP models – both criticized in earlier reviews – are investigated. Moreover, the paper provides an overview on a larger set of models with regular/repeated policy application that apply variants of PMP. Results show that most applications today avoid arbitrary parameter specifications and rely on exogenous information on supply responses to calibrate model parameters. However, only few approaches use multiple observations to estimate parameters, which is likely due to the still considerable technical challenges associated with it. Equally, we found only limited reflection on the behavioral or technological assumptions that could rationalise the PMP model structure while still keeping the model’s advantages.

  5. Applying Monte Carlo Concept and Linear Programming in Modern Portfolio Theory to Obtain Best Weighting Structure

    Directory of Open Access Journals (Sweden)

    Tumpal Sihombing

    2013-01-01

    Full Text Available The world is entering the era of recession when the trend is bearish and market is not so favorable. The capital markets in every major country were experiencing great amount of loss and people suffered in their investment. The Jakarta Composite Index (JCI has shown a great downturn for the past one year but the trend bearish year of the JCI. Therefore, rational investors should consider restructuring their portfolio to set bigger proportion in bonds and cash instead of stocks. Investors can apply modern portfolio theory by Harry Markowitz to find the optimum asset allocation for their portfolio. Higher return is always associated with higher risk. This study shows investors how to find out the lowest risk of a portfolio investment by providing them with several structures of portfolio weighting. By this way, investor can compare and make the decision based on risk-return consideration and opportunity cost as well. Keywords: Modern portfolio theory, Monte Carlo, linear programming

  6. The Soreq Applied Research Accelerator Facility (SARAF): Overview, research programs and future plans

    Science.gov (United States)

    Mardor, Israel; Aviv, Ofer; Avrigeanu, Marilena; Berkovits, Dan; Dahan, Adi; Dickel, Timo; Eliyahu, Ilan; Gai, Moshe; Gavish-Segev, Inbal; Halfon, Shlomi; Hass, Michael; Hirsh, Tsviki; Kaiser, Boaz; Kijel, Daniel; Kreisel, Arik; Mishnayot, Yonatan; Mukul, Ish; Ohayon, Ben; Paul, Michael; Perry, Amichay; Rahangdale, Hitesh; Rodnizki, Jacob; Ron, Guy; Sasson-Zukran, Revital; Shor, Asher; Silverman, Ido; Tessler, Moshe; Vaintraub, Sergey; Weissman, Leo

    2018-05-01

    The Soreq Applied Research Accelerator Facility (SARAF) is under construction in the Soreq Nuclear Research Center at Yavne, Israel. When completed at the beginning of the next decade, SARAF will be a user facility for basic and applied nuclear physics, based on a 40 MeV, 5 mA CW proton/deuteron superconducting linear accelerator. Phase I of SARAF (SARAF-I, 4 MeV, 2 mA CW protons, 5 MeV 1 mA CW deuterons) is already in operation, generating scientific results in several fields of interest. The main ongoing program at SARAF-I is the production of 30 keV neutrons and measurement of Maxwellian Averaged Cross Sections (MACS), important for the astrophysical s-process. The world leading Maxwellian epithermal neutron yield at SARAF-I (5 × 10^{10} epithermal neutrons/s), generated by a novel Liquid-Lithium Target (LiLiT), enables improved precision of known MACSs, and new measurements of low-abundance and radioactive isotopes. Research plans for SARAF-II span several disciplines: precision studies of beyond-Standard-Model effects by trapping light exotic radioisotopes, such as 6He, 8Li and 18, 19, 23Ne, in unprecedented amounts (including meaningful studies already at SARAF-I); extended nuclear astrophysics research with higher energy neutrons, including generation and studies of exotic neutron-rich isotopes relevant to the rapid (r-) process; nuclear structure of exotic isotopes; high energy neutron cross sections for basic nuclear physics and material science research, including neutron induced radiation damage; neutron based imaging and therapy; and novel radiopharmaceuticals development and production. In this paper we present a technical overview of SARAF-I and II, including a description of the accelerator and its irradiation targets; a survey of existing research programs at SARAF-I; and the research potential at the completed facility (SARAF-II).

  7. Applying linear programming model to aggregate production planning of coated peanut products

    Science.gov (United States)

    Rohmah, W. G.; Purwaningsih, I.; Santoso, EF S. M.

    2018-03-01

    The aim of this study was to set the overall production level for each grade of coated peanut product to meet market demands with a minimum production cost. The linear programming model was applied in this study. The proposed model was used to minimize the total production cost based on the limited demand of coated peanuts. The demand values applied to the method was previously forecasted using time series method and production capacity aimed to plan the aggregate production for the next 6 month period. The results indicated that the production planning using the proposed model has resulted a better fitted pattern to the customer demands compared to that of the company policy. The production capacity of product family A, B, and C was relatively stable for the first 3 months of the planning periods, then began to fluctuate over the next 3 months. While, the production capacity of product family D and E was fluctuated over the 6-month planning periods, with the values in the range of 10,864 - 32,580 kg and 255 – 5,069 kg, respectively. The total production cost for all products was 27.06% lower than the production cost calculated using the company’s policy-based method.

  8. NASA Applied Sciences' DEVELOP National Program: a unique model cultivating capacity in the geosciences

    Science.gov (United States)

    Ross, K. W.; Favors, J. E.; Childs-Gleason, L. M.; Ruiz, M. L.; Rogers, L.; Allsbrook, K. N.

    2013-12-01

    The NASA DEVELOP National Program takes a unique approach to cultivating the next generation of geoscientists through interdisciplinary research projects that address environmental and public policy issues through the application of NASA Earth observations. Competitively selected teams of students, recent graduates, and early career professionals take ownership of project proposals outlining basic application concepts and have ten weeks to research core scientific challenges, engage partners and end-users, demonstrate prototypical solutions, and finalize and document their results and outcomes. In this high pressure, results-driven environment emerging geoscience professionals build strong networks, hone effective communication skills, and learn how to call on the varied strengths of a multidisciplinary team to achieve difficult objectives. The DEVELOP approach to workforce development has a variety of advantages over classic apprenticeship-style internship systems. Foremost is the experiential learning of grappling with real-world applied science challenges as a primary actor instead of as an observer or minor player. DEVELOP participants gain experience that fosters personal strengths and service to others, promoting a balance of leadership and teamwork in order to successfully address community needs. The program also advances understanding of Earth science data and technology amongst participants and partner organizations to cultivate skills in managing schedules, risks and resources to best optimize outcomes. Individuals who come through the program gain experience and networking opportunities working within NASA and partner organizations that other internship and academic activities cannot replicate providing not only skill development but an introduction to future STEM-related career paths. With the competitive nature and growing societal role of science and technology in today's global community, DEVELOP fosters collaboration and advances environmental

  9. Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory

    Science.gov (United States)

    Shedlock, Devon J.; Shen, Hao

    2003-04-01

    Although primary CD8 responses to acute infections are independent of CD4 help, it is unknown whether a similar situation applies to secondary responses. We show that depletion of CD4 cells during the recall response has minimal effect, whereas depletion during the priming phase leads to reduced responses by memory CD8 cells to reinfection. Memory CD8 cells generated in CD4+/+ mice responded normally when transferred into CD4-/- hosts, whereas memory CD8 cells generated in CD4-/- mice mounted defective recall responses in CD4+/+ adoptive hosts. These results demonstrate a previously undescribed role for CD4 help in the development of functional CD8 memory.

  10. CD147-mediated chemotaxis of CD4+CD161+ T cells may contribute to local inflammation in rheumatoid arthritis.

    Science.gov (United States)

    Lv, Minghua; Miao, Jinlin; Zhao, Peng; Luo, Xing; Han, Qing; Wu, Zhenbiao; Zhang, Kui; Zhu, Ping

    2018-01-01

    CD161 is used as a surrogate marker for Th17 cells, which are implicated in the pathogenesis of rheumatoid arthritis (RA). In this study, we evaluated the percentage, clinical significance, and CD98 and CD147 expression of CD4 + CD161 + T cells. The potential role of CD147 and CD98 in cyclophilin A-induced chemotaxis of CD4 + CD161 + T cells was analyzed. Thirty-seven RA patients, 15 paired synovial fluid (SF) of RA, and 22 healthy controls were recruited. The cell populations and surface expression of CD98 and CD147 were analyzed by flow cytometry. Spearman's rank correlation coefficient and multiple linear regression were applied to calculate the correlations. Chemotaxis assay was used to investigate CD4 + CD161 + T cell migration. We found that the percentage of CD4 + CD161 + T cells and their expression of CD147 and CD98 in SF were higher than in the peripheral blood of RA patients. Percentage of SF CD4 + CD161 + T cells was positively correlated with 28-Joint Disease Activity Score (DAS28). CD147 monoclonal antibody (HAb18) attenuated the chemotactic ability of CD4 + CD161 + T cells. An increased CD4 + CD161 + T cell percentage and expression of CD147 and CD98 were shown in RA SF. Percentage of SF CD4 + CD161 + T cells can be used as a predictive marker of disease activity in RA. CD147 block significantly decreased the chemotactic index of CD4 + CD161 + cells induced by cyclophilin A (CypA). These results imply that the accumulation of CD4 + CD161 + T cells in SF and their high expression of CD147 may be associated with CypA-mediated chemotaxis and contribute to local inflammation in RA.

  11. 45 CFR 309.170 - What statistical and narrative reporting requirements apply to Tribal IV-D programs?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false What statistical and narrative reporting... (IV-D) PROGRAM Statistical and Narrative Reporting Requirements § 309.170 What statistical and narrative reporting requirements apply to Tribal IV-D programs? (a) Tribes and Tribal organizations...

  12. 49 CFR 17.6 - What procedures apply to the selection of programs and activities under these regulations?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What procedures apply to the selection of programs and activities under these regulations? 17.6 Section 17.6 Transportation Office of the Secretary of Transportation INTERGOVERNMENTAL REVIEW OF DEPARTMENT OF TRANSPORTATION PROGRAMS AND ACTIVITIES § 17.6 What...

  13. 20 CFR 645.260 - What health and safety provisions apply to participants in Welfare-to-Work programs?

    Science.gov (United States)

    2010-04-01

    ... Administrative Requirements § 645.260 What health and safety provisions apply to participants in Welfare-to-Work... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What health and safety provisions apply to participants in Welfare-to-Work programs? 645.260 Section 645.260 Employees' Benefits EMPLOYMENT AND TRAINING...

  14. Identification of the Competencies Needed to Apply Social Marketing to Extension Programming: Results of a Delphi Study

    Science.gov (United States)

    Warner, Laura A.; Stubbs, Eric; Murphrey, Theresa Pesl; Huynh, Phuong

    2016-01-01

    The purpose of this study was to identify the specific competencies needed to apply social marketing, a promising approach to behavior change, to Extension programming. A modified Delphi study was used to achieve group consensus among a panel of experts on the skills, characteristics, and knowledge needed to successfully apply this behavior change…

  15. Energy Programs at the Johns Hopkins University Applied Physics Laboratory, Quarterly Report, October-December 1980

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-12-01

    The Johns Hopkins University Applied Physics Laboratory is engaged in developing energy resources, utilization concepts, and monitoring and storage methods. This Quarterly Report summarizes the work on the various tasks as of 31 December 1980. The Energy Quarterly Report is divided into five sections. The first, Geothermal Energy Development Planning and Technical Assistance, supported by the Department of Energy/Division of Geothermal Energy (DOE/DGE), contains reports on the progress of geothermal-related tasks on which effort was concentrated during the quarter. The second section, Operational Research, Hydroelectric Power Development, supported by the Department of Energy/Resource Applications (DOE/RA), contains a report on institutional problems for small-scale hydroelectric power development in the southeastern states and a list of documents published by APL in the hydroelectric program and in the geothermal program, above. The third section, Seismotectonic Investigations, contains an article on work on the geologic structure of the Danbury Quadrangle that is supported by the Reactor Safety Research Division of the Nuclear Regulatory Commission (NRC) and an in-house supported study on a new method for assessing earthquakes in intraplate regions. The fourth section, Energy Conversion and Storage Techniques, contains four articles. The first is an evaluation of the Einstein refrigerator, supported by independent IR and D funds. The second concerns fly-wheel technology development at APL supported by the Department of Energy, Division of Energy Storage (DOE/STOR). The third is a report on APL energy conservation efforts at its own buildings, and the fourth is an article on liquefied natural gas (LNG) safety evaluation, supported by the National Academy of Sciences. The fifth section explores the value of establishing an Energy Research Institute at The Johns Hopkins University.

  16. CD4 Counts at Entry to HIV Care in Mexico for Patients under the "Universal Antiretroviral Treatment Program for the Uninsured Population," 2007-2014.

    Science.gov (United States)

    Hernández-Romieu, Alfonso C; del Rio, Carlos; Hernández-Ávila, Juan Eugenio; Lopez-Gatell, Hugo; Izazola-Licea, José Antonio; Uribe Zúñiga, Patricia; Hernández-Ávila, Mauricio

    2016-01-01

    In Mexico, public health services have provided universal access to antiretroviral therapy (ART) since 2004. For individuals receiving HIV care in public healthcare facilities, the data are limited regarding CD4 T-lymphocyte counts (CD4e) at the time of entry into care. Relevant population-based estimates of CD4e are needed to inform strategies to maximize the impact of Mexico's national ART program, and may be applicable to other countries implementing universal HIV treatment programs. For this study, we retrospectively analyzed the CD4e of persons living with HIV and receiving care at state public health facilities from 2007 to 2014, comparing CD4e by demographic characteristics and the marginalization index of the state where treatment was provided, and assessing trends in CD4e over time. Our sample included 66,947 individuals who entered into HIV care between 2007 and 2014, of whom 79% were male. During the study period, the male-to-female ratio increased from 3.0 to 4.3, reflecting the country's HIV epidemic; the median age at entry decreased from 34 years to 32 years. Overall, 48.6% of individuals entered care with a CD4≤200 cells/μl, ranging from 42.2% in states with a very low marginalization index to 52.8% in states with a high marginalization index, and from 38.9% among individuals aged 18-29 to 56.5% among those older than 50. The adjusted geometric mean (95% confidence interval) CD4e increased among males from 135 (131,142) cells/μl in 2007 to 148 (143,155) cells/μl in 2014 (p-valuewomen, with a geometric mean of 178 (171,186) and 171 (165,183) in 2007 and 2014, respectively. There have been important gains in access to HIV care and treatment; however, late entry into care remains an important barrier in achieving optimal outcomes of ART in Mexico. The geographic, socioeconomic, and demographic differences observed reflect important inequities in timely access to HIV prevention, care, and treatment services, and highlight the need to develop

  17. CD4 Counts at Entry to HIV Care in Mexico for Patients under the "Universal Antiretroviral Treatment Program for the Uninsured Population," 2007-2014.

    Directory of Open Access Journals (Sweden)

    Alfonso C Hernández-Romieu

    Full Text Available In Mexico, public health services have provided universal access to antiretroviral therapy (ART since 2004. For individuals receiving HIV care in public healthcare facilities, the data are limited regarding CD4 T-lymphocyte counts (CD4e at the time of entry into care. Relevant population-based estimates of CD4e are needed to inform strategies to maximize the impact of Mexico's national ART program, and may be applicable to other countries implementing universal HIV treatment programs. For this study, we retrospectively analyzed the CD4e of persons living with HIV and receiving care at state public health facilities from 2007 to 2014, comparing CD4e by demographic characteristics and the marginalization index of the state where treatment was provided, and assessing trends in CD4e over time. Our sample included 66,947 individuals who entered into HIV care between 2007 and 2014, of whom 79% were male. During the study period, the male-to-female ratio increased from 3.0 to 4.3, reflecting the country's HIV epidemic; the median age at entry decreased from 34 years to 32 years. Overall, 48.6% of individuals entered care with a CD4≤200 cells/μl, ranging from 42.2% in states with a very low marginalization index to 52.8% in states with a high marginalization index, and from 38.9% among individuals aged 18-29 to 56.5% among those older than 50. The adjusted geometric mean (95% confidence interval CD4e increased among males from 135 (131,142 cells/μl in 2007 to 148 (143,155 cells/μl in 2014 (p-value<0.0001; no change was observed among women, with a geometric mean of 178 (171,186 and 171 (165,183 in 2007 and 2014, respectively. There have been important gains in access to HIV care and treatment; however, late entry into care remains an important barrier in achieving optimal outcomes of ART in Mexico. The geographic, socioeconomic, and demographic differences observed reflect important inequities in timely access to HIV prevention, care, and treatment

  18. Global Trends in CD4 Cell Count at the Start of Antiretroviral Therapy: Collaborative Study of Treatment Programs

    NARCIS (Netherlands)

    Anderegg, Nanina; Panayidou, Klea; Abo, Yao; Alejos, Belen; Althoff, Keri N.; Anastos, Kathryn; Antinori, Andrea; Balestre, Eric; Becquet, Renaud; Castagna, Antonella; Castelnuovo, Barbara; Chêne, Geneviève; Coelho, Lara; Collins, Intira Jeannie; Costagliola, Dominique; Crabtree-Ramírez, Brenda; Dabis, Francois; D'Arminio Monforte, Antonella; Davies, Mary-Ann; de Wit, Stéphane; Delpech, Valérie; de La Mata, Nicole L.; Duda, Stephany; Freeman, Aimee; Gange, Stephen J.; Grabmeier-Pfistershammer, Katharina; Gunsenheimer-Bartmeyer, Barbara; Jiamsakul, Awachana; Kitahata, Mari M.; Law, Matthew; Manzardo, Christian; McGowan, Catherine; Meyer, Laurence; Moore, Richard; Mussini, Cristina; Nakigoz, Gertrude; Nash, Denis; tek Ng, Oon; Obel, Niels; Pantazis, Nikos; Poda, Armel; Raben, Dorthe; Reiss, Peter; Riggen, Larry; Sabin, Caroline; d'Amour Sinayobye, Jean; Sönnerborg, Anders; Stoeckle, Marcel; Thorne, Claire; Torti, Carlo

    2018-01-01

    Early initiation of combination antiretroviral therapy (cART), at higher CD4 cell counts, prevents disease progression and reduces sexual transmission of human immunodeficiency virus (HIV). We describe the temporal trends in CD4 cell counts at the start of cART in adults from low-income,

  19. CHAP: a composite nuclear plant simulation program applied to the 3000 MW(t) HTGR

    International Nuclear Information System (INIS)

    Secker, P.A.; Bailey, P.G.; Gilbert, J.S.; Willcutt, G.J.E. Jr.; Vigil, J.C.

    1977-01-01

    The Composite HTGR Analysis Program (CHAP) is a general systems analysis program which has been developed at LASL. The program is being used for simulating large HTGR nuclear power plant operation and accident transients. The general features and analytical methods of the CHAP program are discussed. Features of the large HTGR model and results of model transients are also presented

  20. Student Experiences: the 2013 Cascadia Initiative Expedition Team's Apply to Sail Program

    Science.gov (United States)

    Mejia, H.; Hooft, E. E.; Fattaruso, L.

    2013-12-01

    During the summer of 2013, the Cascadia Initiative Expedition Team led six oceanographic expeditions to recover and redeploy ocean bottom seismometers (OBSs) across the Cascadia subduction zone and Juan de Fuca plate. The Cascadia Initiative (CI) is an onshore/offshore seismic and geodetic experiment to study questions ranging from megathrust earthquakes to volcanic arc structure to the formation, deformation and hydration of the Juan de Fuca and Gorda plates with the overarching goal of understanding the entire subduction zone system. The Cascadia Initiative Expedition Team is a team of scientists charged with leading the oceanographic expeditions to deploy and recover CI OBSs and developing the associated Education and Outreach effort. Students and early career scientists were encouraged to apply to join the cruises via the Cascadia Initiative Expedition Team's Apply to Sail Program. The goal of this call for open participation was to help expand the user base of OBS data by providing opportunities for students and scientists to directly experience at-sea acquisition of OBS data. Participants were required to have a strong interest in learning field techniques, be willing to work long hours at sea assisting in OBS deployment, recovery and preliminary data processing and have an interest in working with the data collected. In total, there were 51 applicants to the Apply to Sail Program from the US and 4 other countries; 21 graduate students as well as a few undergraduate students, postdocs and young scientists from the US and Canada were chosen to join the crew. The cruises lasted from 6 to 14 days in length. OBS retrievals comprised the three first legs, of which the first two were aboard the Research Vessel Oceanus. During each of the retrievals, multiple acoustic signals were sent while the vessel completed a semi-circle around the OBS to accurately determine its position, a final signal was sent to drop the seismometer's anchor, and finally the ship and crew

  1. Recent Weather Technologies Delivered to America's Space Program by the Applied Meteorology Unit

    Science.gov (United States)

    Bauman, WIlliam, H., III; Crawford, Winifred

    2009-01-01

    The Applied Meteorology Unit (AMU) is a unique joint venture of NASA, the Air Force and the National Weather Service (NWS) and has been supporting the Space Program for nearly two decades. The AMU acts as a bridge between the meteorological research community and operational forecasters by developing, evaluating and transitioning new technology and techniques to improve weather support to spaceport operations at the Eastern Range (ER) and Kennedy Space Center. Its primary customers are the 45th Weather Squadron at Cape Canaveral Air Force Station (CCAFS), the Spaceflight Meteorology Group at Johnson Space Center and the National Weather Service Office in Melbourne, FL. Its products are used to support NASA's Shuttle and ELV programs as well as Department of Defense and commercial launches from the ER. Shuttle support includes landing sites beyond the ER. The AMU is co-located with the Air Force operational forecasters at CCAFS to facilitate continuous two-way interaction between the AMU and its operational customers. It is operated under a NASA, Air Force, and NWS Memorandum of Understanding (MOU) by a competitively-selected contractor. The contract, which is funded and managed by NASA, provides five full time professionals with degrees in meteorology or related fields, some of whom also have operational experience. NASA provides a Ph.D.- level NASA civil service scientist as Chief of the AMU. The AMU is tasked by its customers through a unique, nationally recognized process. The tasks are limited to development, evaluation and operational transition of technology to improve weather support to spaceport operations and providing expert advice to the customers. The MOU expressly forbids using the AMU resources to conduct operations or do basic research. The presentation will provide a brief overview of the AMU and how it is tasked by its customers to provide high priority products and services. The balance of the presentation will cover a sampling of products

  2. The Applied Meteorology Unit: Nineteen Years Successfully Transitioning Research into Operations for America's Space Program

    Science.gov (United States)

    Madura, John T.; Bauman, William H.; Merceret, Francis J.; Roeder, William P.; Brody, Frank C.; Hagemeyer, Bartlett C.

    2010-01-01

    The Applied Meteorology Unit (AMU) provides technology transition and technique development to improve operational weather support to the Space Shuttle and the entire American space program. The AMU is funded and managed by NASA and operated by a contractor that provides five meteorologists with a diverse mix of advanced degrees, operational experience, and associated skills including data processing, statistics, and the development of graphical user interfaces. The AMU's primary customers are the U.S. Air Force 45th Weather Squadron at Patrick Air Force Base, the National Weather Service Spaceflight Meteorology Group at NASA Johnson Space Center, and the National Weather Service Melbourne FL Forecast Office. The AMU has transitioned research into operations for nineteen years and worked on a wide range of topics, including new forecasting techniques for lightning probability, synoptic peak winds,.convective winds, and summer severe weather; satellite tools to predict anvil cloud trajectories and evaluate camera line of sight for Space Shuttle launch; optimized radar scan strategies; evaluated and implemented local numerical models; evaluated weather sensors; and many more. The AMU has completed 113 projects with 5 more scheduled to be completed by the end of 2010. During this rich history, the AMU and its customers have learned many lessons on how to effectively transition research into operations. Some of these lessons learned include collocating with the operational customer and periodically visiting geographically separated customers, operator submitted projects, consensus tasking process, use of operator primary advocates for each project, customer AMU liaisons with experience in both operations and research, flexibility in adapting the project plan based on lessons learned during the project, and incorporating training and other transition assistance into the project plans. Operator involvement has been critical to the AMU's remarkable success and many awards

  3. Management options for implementing a basic and applied research program responsive to CS technology base needs. Task VIII. Review existing CS materials R and D programs

    Energy Technology Data Exchange (ETDEWEB)

    1980-02-28

    Possibilities for setting up a basic and applied research program that would be responsive to the Conservation and Solar energy base needs are considered with emphasis on the area of materials research. Several organizational arrangements for the implementation of this basic and applied research program are described and analyzed. The key functions of the system such as resources allocation, and program coordination and management follow from two fundamental characteristics: assignment of lead responsibility (CS and the Office of Energy Research, ER); and nature of the organizational chain-of-command. Three options are categorized in terms of these two characteristics and discussed in detail. The first option retains lead responsibility in ER, with CS personnel exercising sign-off authority and filling the coordination role. Option 2 places lead responsibility with CS program office management, and utilizes the existing chain-of-command, but adds a Basic and Applied Research Division to each program office. Option 3 also places lead responsibility with CS, but within a new Office of Basic and Applied Research, which would include a Research Coordinator to manage interactions with ER, and Research Managers for each CS program area. (MCW)

  4. 34 CFR 655.3 - What regulations apply to the International Education Programs?

    Science.gov (United States)

    2010-07-01

    ... Foreign Language and Area Studies or Foreign Language and International Studies); (2) 34 CFR part 657 (Foreign Language and Area Studies Fellowships Program); (3) 34 CFR part 658 (Undergraduate International Studies and Foreign Language Program); (4) 34 CFR part 660 (International Research and Studies Program...

  5. A Logic Programming Based Approach to Applying Abstract Interpretation to Embedded Software

    DEFF Research Database (Denmark)

    Henriksen, Kim Steen

    anvendt til at analysere programmer udviklet til indlejrede systemer. Et givet indlejret system modelleres som en emulator skrevet i en variant af logikprogrammering kaldet constraint logic programming (CLP). Emulatoren specialiseres med hensyn til et givet program, hvilket resulterer i et nyt program i...... programmeringsparadigme der har et solidt matematisk fundament. Et af dets karakteristika er adskillelsen af logik (betydningen af et program) og kontrol (hvordan programmet udføres), hvilket gør logikprogrammering til et meget anvendeligt sprog hvad angår programanalyse. I denne afhandling bliver logikprogrammering...... skrevet i sproget CLP der samtidig er isomorft med programmet skrevet til det indlejrede system. Anvendes abstract interpretation baserede analysatorer på det specialiserede program, kan resultater fra denne analyse direkte overføres til den indlejrede program, da dette program og den specialiserede...

  6. Preventing childhood anxiety disorders: Is an applied game as effective as a cognitive behavioral therapy-based program?

    OpenAIRE

    Schoneveld, E.A.; Lichtwarck-Aschoff, A.; Granic, I.

    2018-01-01

    A large proportion of children experience subclinical levels of anxiety and cognitive-behavioral therapy (CBT) aimed at preventing anxiety disorders is moderately effective. However, most at-risk children do not seek help or drop out of programs prematurely because of stigma, lack of motivation, and accessibility barriers. Applied games have received increased attention as viable alternatives and have shown promising results, but direct comparisons between applied games and the gold-standard ...

  7. The effect of a 12-week combinational exercise program on CD4 count and mental health among HIV infected women: A randomized control trial

    Directory of Open Access Journals (Sweden)

    Mostafa Dianatinasab

    2018-04-01

    Full Text Available Background/objective: There are conflicting results regarding the effects of exercise on immune function of HIV positive patients. Exercise can also be beneficial to psychological functioning of the patients. The purpose of this study was to determine the impact of a 12-week aerobic and resistance exercise training program on mental health and CD4 counts among female HIV+ patients. Methods: This clinical trial was conducted between September and December 2013. Forty participants (women age range 20–40 were carefully selected from 240 HIV-positive women referred to Voluntary Counseling and Treatment Center (VCT and randomly assigned to either exercise (80 min of aerobic and strength training while receiving the VCT's routine services group (n = 20 or control (received the VCT's routine services only group (n = 20. To assess their mental health status, all participants completed GHQ28 questionnaire. Blood samples were collected to measure CD4 and T-cell counts at baseline and at the end of the 12-week intervention. Results: From a sample of 40 women with HIV infection, the data of 30 participants [experimental group (14 and control group (16] were analyzed (participation rate 75%. The results indicated that after the intervention program, a significant difference in CD4 cell counts was found between the two groups (P = 0.01. With regard to mental health, after performing intervention, significant improvement in all subscales including anxiety disorder, social function, depression and mental health's total score was observed in the exercise compared to the control groups (P < 0.001. Conclusion: Exercise training can be included in health care services in order to improve the mental health status of women with HIV infection. No effect on CD4 count was detected. Keywords: Exercises training, Mental health, CD4 count, HIV infected women

  8. Simulation of the behaviour of a set of Cu/sub 2/S-CdS unit photocells. [Spice II program

    Energy Technology Data Exchange (ETDEWEB)

    Jacquemin, J L; Bordure, G

    1982-03-01

    With the help of a general simulation program (the Spice II program from the University of California, Berkeley), adapted to photocell modeling, authors studied the behavior of a large solar photocell consisting of smaller Cu/sub 2/S-CdS unit solar cells in parallel, in particular, a theoretical set of photocells identical with the best cell made in the laboratory, a set of 30 real photocells characterized individually and the effect of introducing low efficiency cells. The role of each parameter characterizing the photocells is indicated, in order to improve the behavior of photovoltaic panels of larger dimensions. 2 refs.

  9. Promoting Behavior Change Using Social Norms: Applying a Community Based Social Marketing Tool to Extension Programming

    Science.gov (United States)

    Chaudhary, Anil Kumar; Warner, Laura A.

    2015-01-01

    Most educational programs are designed to produce lower level outcomes, and Extension educators are challenged to produce behavior change in target audiences. Social norms are a very powerful proven tool for encouraging sustainable behavior change among Extension's target audiences. Minor modifications to program content to demonstrate the…

  10. Applying Sleep Research to University Students: Recommendations for Developing a Student Sleep Education Program.

    Science.gov (United States)

    Brown, Franklin C.; Buboltz, Walter C., Jr.

    2002-01-01

    Many students are unaware that academic difficulties may be related to their sleep habits. This article introduces key elements of a student sleep education program that can be easily incorporated into many universities first-year orientation classes or as part of residential housing programs. (Author)

  11. 28 CFR 90.101 - What definitions apply for the grant program?

    Science.gov (United States)

    2010-07-01

    ... program? 90.101 Section 90.101 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) VIOLENCE AGAINST... education is defined to include an educational institution in any State that admits as regular students only... beyond secondary education; provides an educational program for which the institution has been granted...

  12. Syllabus for an Associate Degree Program in Applied Marine Biology and Oceanography.

    Science.gov (United States)

    Banerjee, Tapan

    Included is a detailed outline of the content of each course required or offered as an elective in the associate degree program. With an 18 or 19 unit load each semester the program requires two years, and includes 64 hours at sea every semester. In addition to chemistry, physics, biology, and oceanography courses, there is a required course in…

  13. 34 CFR 206.5 - What definitions apply to these programs?

    Science.gov (United States)

    2010-07-01

    ... ENGAGED IN MIGRANT AND OTHER SEASONAL FARMWORK-HIGH SCHOOL EQUIVALENCY PROGRAM AND COLLEGE ASSISTANCE...; or (C) Is beyond the age of compulsory school attendance in that State and has the ability to benefit... awards a bachelor's degree; or (B) At least a two-year program that is acceptable for full credit toward...

  14. What's in a Name? Degree Programs and What They Tell Us about "Applied Linguistics" in Australia

    Science.gov (United States)

    Murray, Neil; Crichton, Jonathan

    2010-01-01

    In this paper we explore the provision of applied linguistics within Australian universities. We focus on how the "what" of applied linguistics, as captured in scholarly definitions of the discipline, accords with the "where", as captured in potential contexts of application as these are manifested in provision. In doing so, we…

  15. 28 CFR 30.6 - What procedures apply to the selection of programs and activities under these regulations?

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false What procedures apply to the selection of programs and activities under these regulations? 30.6 Section 30.6 Judicial Administration DEPARTMENT OF... consult with local elected officials. (b) Each state that adopts a process shall notify the Attorney...

  16. 13 CFR 124.203 - What must a concern submit to apply to the 8(a) BD program?

    Science.gov (United States)

    2010-01-01

    ... to, financial statements, Federal personal and business tax returns, and personal history statements... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What must a concern submit to apply to the 8(a) BD program? 124.203 Section 124.203 Business Credit and Assistance SMALL BUSINESS...

  17. Usage of I++ Simulator to Program Coordinate Measuring Machines when Common Programming Methods are difficult to apply

    Directory of Open Access Journals (Sweden)

    Gąska A.

    2014-02-01

    Full Text Available Nowadays, simulators facilitate tasks performed daily by the engineers of different branches, including coordinate metrologists. Sometimes it is difficult or almost impossible to program a Coordinate Measuring Machine (CMM using standard methods. This happens, for example, during measurements of nano elements or in cases when measurements are performed on high-precision (accurate measuring machines which work in strictly air-conditioned spaces and the presence of the operator in such room during the programming of CMM could cause an increase in temperature, which in turn could make it necessary to wait some time until conditions stabilize. This article describes functioning of a simulator and its usage during Coordinate Measuring Machine programming in the latter situation. Article also describes a general process of programming CMMs which ensures the correct machine performance after starting the program on a real machine. As an example proving the presented considerations, measurement of exemplary workpiece, which was performed on the machine working in the strictly air-conditioned room, was described

  18. Applying the chronic care model to an employee benefits program: a qualitative inquiry.

    Science.gov (United States)

    Schauer, Gillian L; Wilson, Mark; Barrett, Barbara; Honeycutt, Sally; Hermstad, April K; Kegler, Michelle C

    2013-12-01

    To assess how employee benefits programs may strengthen and/or complement elements of the chronic care model (CCM), a framework used by health systems to improve chronic illness care. A qualitative inquiry consisting of semi-structured interviews with employee benefit administrators and partners from a self-insured, self-administered employee health benefits program was conducted at a large family-owned business in southwest Georgia. Results indicate that the employer adapted and used many health system-related elements of the CCM in the design of their benefit program. Data also suggest that the employee benefits program contributed to self-management skills and to informing and activating patients to interact with the health system. Findings suggest that employee benefits programs can use aspects of the CCM in their own benefit design, and can structure their benefits to contribute to patient-related elements from the CCM.

  19. Paratingent Derivative Applied to the Measure of the Sensitivity in Multiobjective Differential Programming

    Directory of Open Access Journals (Sweden)

    F. García

    2013-01-01

    Full Text Available We analyse the sensitivity of differential programs of the form subject to where and are maps whose respective images lie in ordered Banach spaces. Following previous works on multiobjective programming, the notion of -optimal solution is used. The behaviour of some nonsingleton sets of -optimal solutions according to changes of the parameter in the problem is analysed. The main result of the work states that the sensitivity of the program is measured by a Lagrange multiplier plus a projection of its derivative. This sensitivity is measured by means of the paratingent derivative.

  20. GRUKON - A package of applied computer programs system input and operating procedures of functional modules

    International Nuclear Information System (INIS)

    Sinitsa, V.V.; Rineiskij, A.A.

    1993-04-01

    This manual describes a software package for the production of multigroup neutron cross-sections from evaluated nuclear data files. It presents the information necessary for the implementation of the program's modules in the framework of the execution of the program, including: operating procedures of the program, the data input, the macrocommand language, the assignment of the system's procedures. This report also presents the methodology used in the coding of the individual modules: the rules, the syntax, the method of procedures. The report also presents an example of the application of the data processing module. (author)

  1. Applied physics

    International Nuclear Information System (INIS)

    Anon.

    1980-01-01

    The Physics Division research program that is dedicated primarily to applied research goals involves the interaction of energetic particles with solids. This applied research is carried out in conjunction with the basic research studies from which it evolved

  2. Relevant aspects of a quality assurance program applied to a nuclear power plant operation

    International Nuclear Information System (INIS)

    Fernandez, J.C.

    1987-01-01

    The purpose of this work was to enumerate the most relevant subjects to be taken into account for the elaboration of a Quality Assurance Program aimed to regulate a nuclear power plant operation. At first, it was necessary to point out the relevance that implies the presence of a group of personnel, experienced in quality assurance with enough knowledge on the technical and organizing aspects of the plant. Other aspect to be taken into account was the contemplation of the international requirements, through the International Atomic Energy Agency and of the national requirements that each country had set up by the corresponding regulating agencies. These organizations pointed out the minimum rules that must be followed for the adequate and efficient execution of a program. The Quality Assurance Manual and the program and work procedures constituted the Quality Assurance Program which must be checked as regards its fulfillment by auditors and quality assurance supervisions. (Author)

  3. Applying the National Industrial Security Program (NISP) in the laboratory environment

    International Nuclear Information System (INIS)

    Bruckner, D.G.

    1995-01-01

    With continuing changes in the world safeguards and security environment the effectiveness of many laboratory operations depends on correctly assessing the risk to its programs and developing protection technologies, research and concepts of operations being employed by the scientific community. This paper explores the opportunities afforded by the National Industrial Security Program (NISP) to uniformly and simply protect Laboratory security assets, sensitive and classified information and matter, during all aspects of a laboratory program. The developments in information systems, program security, physical security and access controls suggest an industrial security approach. This paper's overall objective is to indicate that the Laboratory environment is particularly well suited to take advantage being pursued by NISP and the performance objectives of the new DOE orders

  4. 7 CFR 1484.20 - How can my organization apply to the Cooperator program?

    Science.gov (United States)

    2010-01-01

    ... that it is accepting applications for participation in the Cooperator program for a specified marketing... performance of competing suppliers, expected changes in demand, etc.; (ii) The long-term strategy that will be...

  5. 7 CFR 1484.13 - What special definitions apply to the Cooperator program?

    Science.gov (United States)

    2010-01-01

    ... Marketing Programs, FAS, USDA, or designee. Division Director—the director of a commodity division... agricultural commodities or products and does not have a business interest in or receive remuneration from...

  6. 34 CFR 369.44 - What wage and hour standards apply to community rehabilitation programs?

    Science.gov (United States)

    2010-07-01

    ... VOCATIONAL REHABILITATION SERVICE PROJECTS What Conditions Must Be Met by a Grantee? § 369.44 What wage and... hour standards must be observed in projects carried out in community rehabilitation programs...

  7. Multi-image screening technique applied to a general orientation training program

    International Nuclear Information System (INIS)

    Hajek, B.K.; Campbell, T.O.; Evans, A.D.; Hickey, J.M.

    1979-01-01

    A general orientation and training program is a prerequisite for personnel to have unescorted access to various site locations at a nuclear power plant. A new general orientation and training program is being developed for the Toledo Edison Company to be used at the Davis-Besse Nuclear Power Station. The program is presented in a multi-image and stereo sound format that has the unique capability to present the magnitude and scale of the plant, to arouse and maintain the interest of the viewer, and to instill in him a feeling of importance and pride about his job. Satisfactory completion of the program by individuals is assessed and certified by a machine scored test that is administered as an integral part of the presentation

  8. 34 CFR 460.4 - What definitions apply to the adult education programs?

    Science.gov (United States)

    2010-07-01

    ... for adult education programs are defined in 34 CFR 77.1: Applicant Application Award Budget Budget... (including welfare hotels, congregate shelters, and transitional housing for the mentally ill); (ii) An...

  9. Building Sustainable Professional Development Programs: Applying Strategies From Implementation Science to Translate Evidence Into Practice.

    Science.gov (United States)

    Baldwin, Constance D; Chandran, Latha; Gusic, Maryellen E

    2017-01-01

    Multisite and national professional development (PD) programs for educators are challenging to establish. Use of implementation science (IS) frameworks designed to convert evidence-based intervention methods into effective health care practice may help PD developers translate proven educational methods and models into successful, well-run programs. Implementation of the national Educational Scholars Program (ESP) is used to illustrate the value of the IS model. Four adaptable elements of IS are described: (1) replication of an evidence-based model, (2) systematic stages of implementation, (3) management of implementation using three implementation drivers, and (4) demonstration of program success through measures of fidelity to proven models and sustainability. Implementation of the ESP was grounded on five established principles and methods for successful PD. The process was conducted in four IS stages over 10 years: Exploration, Installation, Initial Implementation, and Full Implementation. To ensure effective and efficient processes, attention to IS implementation drivers helped to manage organizational relationships, build competence in faculty and scholars, and address leadership challenges. We describe the ESP's fidelity to evidence-based structures and methods, and offer three examples of sustainability efforts that enabled achievement of targeted program outcomes, including academic productivity, strong networking, and career advancement of scholars. Application of IS frameworks to program implementation may help other PD programs to translate evidence-based methods into interventions with enhanced impact. A PD program can follow systematic developmental stages and be operationalized by practical implementation drivers, thereby creating successful and sustainable interventions that promote the academic vitality of health professions educators.

  10. APPLYING ROBUST RANKING METHOD IN TWO PHASE FUZZY OPTIMIZATION LINEAR PROGRAMMING PROBLEMS (FOLPP

    Directory of Open Access Journals (Sweden)

    Monalisha Pattnaik

    2014-12-01

    Full Text Available Background: This paper explores the solutions to the fuzzy optimization linear program problems (FOLPP where some parameters are fuzzy numbers. In practice, there are many problems in which all decision parameters are fuzzy numbers, and such problems are usually solved by either probabilistic programming or multi-objective programming methods. Methods: In this paper, using the concept of comparison of fuzzy numbers, a very effective method is introduced for solving these problems. This paper extends linear programming based problem in fuzzy environment. With the problem assumptions, the optimal solution can still be theoretically solved using the two phase simplex based method in fuzzy environment. To handle the fuzzy decision variables can be initially generated and then solved and improved sequentially using the fuzzy decision approach by introducing robust ranking technique. Results and conclusions: The model is illustrated with an application and a post optimal analysis approach is obtained. The proposed procedure was programmed with MATLAB (R2009a version software for plotting the four dimensional slice diagram to the application. Finally, numerical example is presented to illustrate the effectiveness of the theoretical results, and to gain additional managerial insights. 

  11. Mars Navigator: An Interactive Multimedia Program about Mars, Aerospace Engineering, Astronomy, and the JPL Mars Missions. [CD-ROM

    Science.gov (United States)

    Gramoll, Kurt

    This CD-ROM introduces basic astronomy and aerospace engineering by examining the Jet Propulsion Laboratory's (JPL) Mars Pathfinder and Mars Global Surveyor missions to Mars. It contains numerous animations and narrations in addition to detailed graphics and text. Six interactive laboratories are included to help understand topics such as the…

  12. Cost-Benefit Analysis applied to the natural gas program for vehicles in the Metropolitan Area of the Aburra Valley

    International Nuclear Information System (INIS)

    Saldarriaga Isaza, Carlos Adrian; Vasquez Sanchez, Edison; Chavarria Munera, Sergio

    2011-01-01

    This article presents the evaluation of the natural gas program for vehicles applied in Metropolitan Area of the Aburra Valley. By using the Cost- Benefit Analysis method, four cost variables were identified: private, fiscal, gas tax, and conversion tax; and three types of benefits: private, fiscal and social. For the environmental social benefit estimation the benefit transfer technique was employed, carrying out meta-analysis function estimation. The cost-benefit net outcome is positive and favors the program application in the study site; in real terms the total profits are about COP$ 803265 million for the complete eight year period it took place (2001- 2008).

  13. Report of a Therapeutic Drama Program in a Federal Prison: Implications for Applied Communication.

    Science.gov (United States)

    Mettee, Dorothy L.

    Noting that new approaches must be found to decrease the numbers of inmates returning to United States prisons and to provide means for productive changes that will result in self-improvement and new options for inmates both inside and outside the prison after their release, a drama program was established in 1979 for inmates at the Federal…

  14. Applying SNP marker technology in the cacao breeding program at the Cocoa Research Institute of Ghana

    Science.gov (United States)

    In this investigation 45 parental cacao plants and five progeny derived from the parental stock studied were genotyped using six SNP markers to determine off-types or mislabeled clones and to authenticate crosses made in the Cocoa Research Institute of Ghana (CRIG) breeding program. Investigation wa...

  15. Applying Theories of Adult Learning in Developing Online Programs in Gerontology

    Science.gov (United States)

    Carter, Christy S.; Solberg, Lauren B.; Solberg, Laurence M.

    2017-01-01

    The Department of Aging and Geriatric Research at the University of Florida College of Medicine has established online education programs to provide healthcare professionals with advanced training in the field of gerontology to establish proficiency in providing quality care to older individuals. A major barrier to creating our online education…

  16. 42 CFR 62.3 - Who is eligible to apply for a scholarship program award?

    Science.gov (United States)

    2010-10-01

    ... enrollment, or be enrolled, as a full-time student in a school located in a State; (2) Be pursuing a course of study or program offered by the school leading to a degree in medicine, osteopathy, dentistry, or... under this part is ineligible for an award unless a written statement satisfactory to the Secretary is...

  17. The Development of a Collegiate Recovery Program: Applying Social Cognitive Theory within a Social Ecological Framework

    Science.gov (United States)

    Beeson, Eric T.; Whitney, Jennifer M.; Peterson, Holly M.

    2017-01-01

    Background: Collegiate recovery programs (CRPs) are emerging as a strategy to provide after-care support to students in recovery from substance use disorders (SUDs) at institutions of higher education. CRPs are an innovative strategy for Health Educators to support the personal, academic, and professional goals of students in recovery. Purpose:…

  18. Applying the International Medical Graduate Program Model to Alleviate the Supply Shortage of Accounting Doctoral Faculty

    Science.gov (United States)

    HassabElnaby, Hassan R.; Dobrzykowski, David D.; Tran, Oanh Thikie

    2012-01-01

    Accounting has been faced with a severe shortage in the supply of qualified doctoral faculty. Drawing upon the international mobility of foreign scholars and the spirit of the international medical graduate program, this article suggests a model to fill the demand in accounting doctoral faculty. The underlying assumption of the suggested model is…

  19. Learning Theories Applied to Teaching Technology: Constructivism versus Behavioral Theory for Instructing Multimedia Software Programs

    Science.gov (United States)

    Reed, Cajah S.

    2012-01-01

    This study sought to find evidence for a beneficial learning theory to teach computer software programs. Additionally, software was analyzed for each learning theory's applicability to resolve whether certain software requires a specific method of education. The results are meant to give educators more effective teaching tools, so students…

  20. 42 CFR 62.24 - Who is eligible to apply for the Loan Repayment Program?

    Science.gov (United States)

    2010-10-01

    ... profession and which is offered by an accredited school in a State or (ii) Be enrolled in an approved... Federal, State or local government entity are not eligible for participation in the Loan Repayment Program. (Approved by the Office of Management and Budget under control number 0915-0127) ...

  1. General design methodology applied to the research domain of physical programming for computer illiterate

    CSIR Research Space (South Africa)

    Smith, Andrew C

    2011-09-01

    Full Text Available The authors discuss the application of the 'general design methodology‘ in the context of a physical computing project. The aim of the project was to design and develop physical objects that could serve as metaphors for computer programming elements...

  2. Applying the creating lasting family connections marriage enhancement program to marriages affected by prison reentry.

    Science.gov (United States)

    Shamblen, Stephen R; Arnold, Brooke B; McKiernan, Patrick; Collins, David A; Strader, Ted N

    2013-09-01

    Divorce proportions are currently high in the US and they are even higher among those who are incarcerated with substance abuse problems. Although much research has examined marital interventions, only two studies have examined marital interventions with prison populations. There is some empirical evidence that incarcerated couples benefit from traditional marital therapy (O'Farrell and Fals-Stewart, 1999, Addictions: A comprehensive guidebook, New York, Oxford University Press). An adaptation of the evidence-based Creating Lasting Family Connections program was implemented with 144 married couples, where one spouse was incarcerated, in a southern state with particularly high divorce and incarceration proportions. Results suggested that married men exposed to the program had larger improvements in some relationship skills relative to a convenience sample of men not so exposed. Both husbands and wives exposed to the program exhibited similar and significant increases in relationship skills. The results were comparable to a Prevention and Relationship Enhancement Program adaptation for inmates. The implications of the findings for prevention practitioners are discussed. © FPI, Inc.

  3. A Self-Administered Parent Training Program Based upon the Principles of Applied Behavior Analysis

    Science.gov (United States)

    Maguire, Heather M.

    2012-01-01

    Parents often respond to challenging behavior exhibited by their children in such a way that unintentionally strengthens it. Applied behavior analysis (ABA) is a research-based science that has been proven effective in remediating challenging behavior in children. Although many parents could benefit from using strategies from the field of ABA with…

  4. Social Science at the Center for Adaptive Optics: Synergistic Systems of Program Evaluation, Applied Research, Educational Assessment, and Pedagogy

    Science.gov (United States)

    Goza, B. K.; Hunter, L.; Shaw, J. M.; Metevier, A. J.; Raschke, L.; Espinoza, E.; Geaney, E. R.; Reyes, G.; Rothman, D. L.

    2010-12-01

    This paper describes the interaction of four elements of social science as they have evolved in concert with the Center for Adaptive Optics Professional Development Program (CfAO PDP). We hope these examples persuade early-career scientists and engineers to include social science activities as they develop grant proposals and carry out their research. To frame our discussion we use a metaphor from astronomy. At the University of California Santa Cruz (UCSC), the CfAO PDP and the Educational Partnership Center (EPC) are two young stars in the process of forming a solar system. Together, they are surrounded by a disk of gas and dust made up of program evaluation, applied research, educational assessment, and pedagogy. An idea from the 2001 PDP intensive workshops program evaluation developed into the Assessing Scientific Inquiry and Leadership Skills (AScILS) applied research project. In iterative cycles, AScILS researchers participated in subsequent PDP intensive workshops, teaching social science while piloting AScILS measurement strategies. Subsequent "orbits" of the PDP program evaluation gathered ideas from the applied research and pedagogy. The denser regions of this disk of social science are in the process of forming new protoplanets as tools for research and teaching are developed. These tools include problem-solving exercises or simulations of adaptive optics explanations and scientific reasoning; rubrics to evaluate the scientific reasoning simulation responses, knowledge regarding inclusive science education, and student explanations of science/engineering inquiry investigations; and a scientific reasoning curriculum. Another applied research project is forming with the design of a study regarding how to assess engineering explanations. To illustrate the mutual shaping of the cross-disciplinary, intergenerational group of educational researchers and their projects, the paper ends with a description of the professional trajectories of some of the

  5. The Effects of Aerobic and Anaerobic Training Programs Applied to Elite Wrestlers on Body Mass Index (BMI) and Blood Lipids

    Science.gov (United States)

    Demirel, Nurcan; Özbay, Serhat; Kaya, Fatih

    2018-01-01

    The purpose of this study is to analyse the effects of aerobic and anaerobic training programs applied to elite wrestlers on body mass index (BMI) and blood lipids. 20 elite wrestlers, whose average age is (experimental group; 15.20 ± 4.61, n = 10), control group; 15.90 ± 2.08, n = 10), participated in the study and they were randomly divided into…

  6. An introduction to geographic information systems as applied to a groundwater remediation program

    International Nuclear Information System (INIS)

    Hammock, J.K.; Lorenz, R.

    1989-01-01

    While the attention to environmental issues has grown over the past several years, so has the focus on groundwater protection. Addressing the task of groundwater remediation often involves a large-scale program with numerous wells and enormous amounts of data. This data must be manipulated and analyzed in an efficient manner for the remediation program to be truly effective. Geographic Information System's (GIS) have proven to be an extremely effective tool in handling and interpreting this type of groundwater information. The purpose of this paper is to introduce the audience to GIS technology, describe how it is being used at the Savannah River Site (SRS) to handle groundwater data and demonstrate how it may be used in the corporate Westinghouse environment

  7. A cost benefit review of applying quality assurance principles to project management of environmental cleanup programs

    International Nuclear Information System (INIS)

    Oakes, T.W.

    1989-01-01

    This paper shows the cost/benefit mechanism used for applying the theory and practical aspects of QA principles as a management tool to project management of environmental cleanup projects. This includes reviewing and guidelines and requirements to determine the practical aspects of applying these requirements to environmental project management. Thus, there is a feedback loop for comparison of the cost/benefits of application of each stage of the project. The project's major stages include planning, environmental sampling, analysis of data samples, data/information management to include reporting, and follow- up, post-cleanup sampling with continued data management. A comparison is also made of the theory with the practical aspects of each of these stages

  8. Principles from history, community psychology and developmental psychology applied to community based programs for deinstitutionalized youth

    OpenAIRE

    Levine, Murray

    2007-01-01

    ABSTRACT: This article analyses the issues of the deinstitutionalization of youth, and the development of community based services, using some historical data and some of the principles of community psychology. The basic premise is that there is no such thing as a social vacuum. All programs are implemented and function in an elaborate social context. RESUMO: Este artigo analisa as questões referentes à desinstitunalização dos jovens e ao desenvolvimento de serviços ...

  9. A precompiler written in SPITBOL applied to programs to analyze nuclear data

    International Nuclear Information System (INIS)

    Winkelmann, K.; Croome, D.

    1985-01-01

    For an interactive data acquisition and analysis system for nuclear physics experiments a precompiler is provided to expand system specific macros in user written analysis programs. It is written with help of the string processing language SPITBOL and generates PL/I or PL-11 code. It is shown that SPITBOL is a suitable precompiler language for this kind of medium size precompile problems. (orig.)

  10. PCARRD's strategies for technology transfer: The agriculture and resources regional technology information system and the regional applied communication program

    International Nuclear Information System (INIS)

    Stuart, T.H.; Mamon, C.R.

    1990-05-01

    This paper describes the Agriculture and Resources Regional Technology Information System (ARRTIS) and the Regional Applied Communication Outreach Program (RAC) of PCARRD. The ARRTIS and the RACO are the strategies in communicating scientific and technology-based information. The ARRTIS is an information system that provides an information base on the status of technologies at various levels of maturity (generation, adaptation, verification, piloting, dissemination and utilization) and offers technology alternatives based on environmental requirements, costs and returns analysis or feasibility of the technologies. This information base provides the repository of technology information from which the Applied Communication Program draws its information for packaging into various formats, using various strategies/media to cater to various users in the regions most especially the farmers. Meanwhile, as PCARRD executes its mission of developing the national research system, it incorporates a development support communication program through the RACO. The RACO is essentially a working component of a regional research center/consortium in each region coordinated by the Applied Communication Division of PCARRD. It aims at reaching farmers and their families, extensionists, administrators, policy makers and entrepreneurs with research information and technology which use a variety of appropriate communication channels, modern communication technology and strategies so that they may actively participate in research diffusion and utilization. (author). 7 refs

  11. Study of author’s applied physical training program for military officers-graduates of reserve officers’ departments

    Directory of Open Access Journals (Sweden)

    A.I. Yavorskyy

    2016-04-01

    Full Text Available Purpose: to test effectiveness of applied physical training program for military officers, called up to military service after graduation from reserve officers’ departments. Material: the research was conducted on the base of Educational center 184 from June 2014 to December 2015. In the research 80 military officers participated (n=30 - graduates of military higher educational establishments; n=26, n=24 - graduates of reserve officers’ departments of 22-27 years’ age. Results: we fulfilled analysis of military officers’ physical fitness by exercises, which characterize general physical fitness and military applied skills (100 meters’ run, chin ups, 3000 meters’ run, passing obstacles course, grenade throws for distance and for accuracy, 5 km march-rush. We worked out the program, the essence of which implies ensuring of physical fitness and acceleration of reserve officers-graduates’ adaptation to professional (combat functioning. Conclusions: it was proved that implementation of the author’s program influenced positively on perfection of general physical qualities and military applied skills of military officers-graduated of reserve officers’ departments (р-0.05-0.001.

  12. Applying established guidelines to team-based learning programs in medical schools: a systematic review.

    Science.gov (United States)

    Burgess, Annette W; McGregor, Deborah M; Mellis, Craig M

    2014-04-01

    Team-based learning (TBL), a structured form of small-group learning, has gained popularity in medical education in recent years. A growing number of medical schools have adopted TBL in a variety of combinations and permutations across a diversity of settings, learners, and content areas. The authors conducted this systematic review to establish the extent, design, and practice of TBL programs within medical schools to inform curriculum planners and education designers. The authors searched the MEDLINE, PubMed, Web of Knowledge, and ERIC databases for articles on TBL in undergraduate medical education published between 2002 and 2012. They selected and reviewed articles that included original research on TBL programs and assessed the articles according to the seven core TBL design elements (team formation, readiness assurance, immediate feedback, sequencing of in-class problem solving, the four S's [significant problem, same problem, specific choice, and simultaneous reporting], incentive structure, and peer review) described in established guidelines. The authors identified 20 articles that satisfied the inclusion criteria. They found significant variability across the articles in terms of the application of the seven core design elements and the depth with which they were described. The majority of the articles, however, reported that TBL provided a positive learning experience for students. In the future, faculty should adhere to a standardized TBL framework to better understand the impact and relative merits of each feature of their program.

  13. Meteonorm. Global meteorological database for solar energy and applied climatology. Version 4.0: edition 2000. Software and data on CD-ROM

    International Nuclear Information System (INIS)

    1999-01-01

    This is a comprehensive meteorological planning tool for system design, targeted at engineers, architects, teachers, planners and anyone interested in solar energy and climatology. METEONORM includes data from 2400 meteorological stations worldwide. Version V4.0 is based on over 15 years in the development of meteorological databases for energy. It may be used for solar applications at any desired location in the world, as an interpolation model of solar radiation and additional parameters for any site in the world is included. Also, with up-to-date algorithms, solar radiation incident on surfaces of arbitrary orientation may be calculated at the touch of a button. The local skyline profile may be specified. Five languages are supported: English, French, German, Italian, Spanish. Sites may be selected on map by means of a graphical interface. User data may be imported. 16 different output formats are available. Data, programme, manual, maps and illustrations are incorporated on the CD-ROM which is available for sale

  14. Building capacity for water, sanitation, and hygiene programming: Training evaluation theory applied to CLTS management training in Kenya.

    Science.gov (United States)

    Crocker, Jonny; Shields, Katherine F; Venkataramanan, Vidya; Saywell, Darren; Bartram, Jamie

    2016-10-01

    Training and capacity building are long established critical components of global water, sanitation, and hygiene (WaSH) policies, strategies, and programs. Expanding capacity building support for WaSH in developing countries is one of the targets of the Sustainable Development Goals. There are many training evaluation methods and tools available. However, training evaluations in WaSH have been infrequent, have often not utilized these methods and tools, and have lacked rigor. We developed a conceptual framework for evaluating training in WaSH by reviewing and adapting concepts from literature. Our framework includes three target outcomes: learning, individual performance, and improved programming; and two sets of influences: trainee and context factors. We applied the framework to evaluate a seven-month community-led total sanitation (CLTS) management training program delivered to 42 government officials in Kenya from September 2013 to May 2014. Trainees were given a pre-training questionnaire and were interviewed at two weeks and seven months after initial training. We qualitatively analyzed the data using our conceptual framework. The training program resulted in trainees learning the CLTS process and new skills, and improving their individual performance through application of advocacy, partnership, and supervision soft skills. The link from trainees' performance to improved programming was constrained by resource limitations and pre-existing rigidity of trainees' organizations. Training-over-time enhanced outcomes and enabled trainees to overcome constraints in their work. Training in soft skills is relevant to managing public health programs beyond WaSH. We make recommendations on how training programs can be targeted and adapted to improve outcomes. Our conceptual framework can be used as a tool both for planning and evaluating training programs in WaSH. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  15. Program for fundamental and applied research of fuel cells in VNIIEF

    Energy Technology Data Exchange (ETDEWEB)

    Anisin, A.V.; Borisseonock, V.A.; Novitskii, Y.Z.; Potyomckin, G.A.

    1996-04-01

    According to VNIIEF the integral part of development of fuel cell power plants is fundamental and applied research. This paper describes areas of research on molten carbonate fuel cells. Topics include the development of mathematical models for porous electrodes, thin film electrolytes, the possibility of solid nickel anodes, model of activation polarization of anode, electrolyte with high solubility of oxygen. Other areas include research on a stationary mode of stack operation, anticorrosion coatings, impedance diagnostic methods, ultrasound diagnostics, radiation treatments, an air aluminium cell, and alternative catalysts for low temperature fuel cells.

  16. Applying an innovative educational program for the education of today's engineers

    International Nuclear Information System (INIS)

    Kans, M

    2012-01-01

    Engineers require a broad spectrum of knowledge and skills: basic skills in mathematics and physics, skills and competencies within the major subject area as well as more general knowledge about business and enterprise contexts, society regulations and understanding of the future professions' characteristics. In addition, social, intercultural, analytical and managing competencies are desired. The CDIO educational program was initiated as a means to come closer to practice and to assure the training of engineering skills that are required of today's engineers. CDIO is short for Conceive-Design-Implement-Operate and describes the full life cycle understanding of a system or asset that engineering students should reach during education. The CDIO initiative is formulated in a program consisting of two important documents: the CDIO standards and the CDIO syllabus. The standards describe a holistic approach on education, from knowledge and skills to be trained, how to train and assess them, to how to develop the teaching staff and the work places for enabling the goals. The specific knowledge and skills to be achieved are accounted for in the syllabus. In this paper we share our more than 15 years of experiences in problem and project based learning from the perspective of the CDIO standards. For each standard, examples of how to set up the education and overcome challenges connected to the standard are given. The paper concludes with recommendations to others wishing to work toward problem and real-life based education without compromising the requirements of a scientific approach.

  17. Applying an innovative educational program for the education of today's engineers

    Science.gov (United States)

    Kans, M.

    2012-05-01

    Engineers require a broad spectrum of knowledge and skills: basic skills in mathematics and physics, skills and competencies within the major subject area as well as more general knowledge about business and enterprise contexts, society regulations and understanding of the future professions' characteristics. In addition, social, intercultural, analytical and managing competencies are desired. The CDIO educational program was initiated as a means to come closer to practice and to assure the training of engineering skills that are required of today's engineers. CDIO is short for Conceive-Design-Implement-Operate and describes the full life cycle understanding of a system or asset that engineering students should reach during education. The CDIO initiative is formulated in a program consisting of two important documents: the CDIO standards and the CDIO syllabus. The standards describe a holistic approach on education, from knowledge and skills to be trained, how to train and assess them, to how to develop the teaching staff and the work places for enabling the goals. The specific knowledge and skills to be achieved are accounted for in the syllabus. In this paper we share our more than 15 years of experiences in problem and project based learning from the perspective of the CDIO standards. For each standard, examples of how to set up the education and overcome challenges connected to the standard are given. The paper concludes with recommendations to others wishing to work toward problem and real-life based education without compromising the requirements of a scientific approach.

  18. Optimization strategies based on sequential quadratic programming applied for a fermentation process for butanol production.

    Science.gov (United States)

    Pinto Mariano, Adriano; Bastos Borba Costa, Caliane; de Franceschi de Angelis, Dejanira; Maugeri Filho, Francisco; Pires Atala, Daniel Ibraim; Wolf Maciel, Maria Regina; Maciel Filho, Rubens

    2009-11-01

    In this work, the mathematical optimization of a continuous flash fermentation process for the production of biobutanol was studied. The process consists of three interconnected units, as follows: fermentor, cell-retention system (tangential microfiltration), and vacuum flash vessel (responsible for the continuous recovery of butanol from the broth). The objective of the optimization was to maximize butanol productivity for a desired substrate conversion. Two strategies were compared for the optimization of the process. In one of them, the process was represented by a deterministic model with kinetic parameters determined experimentally and, in the other, by a statistical model obtained using the factorial design technique combined with simulation. For both strategies, the problem was written as a nonlinear programming problem and was solved with the sequential quadratic programming technique. The results showed that despite the very similar solutions obtained with both strategies, the problems found with the strategy using the deterministic model, such as lack of convergence and high computational time, make the use of the optimization strategy with the statistical model, which showed to be robust and fast, more suitable for the flash fermentation process, being recommended for real-time applications coupling optimization and control.

  19. Multi-criteria model for sustainable development using goal programming applied to the United Arab Emirates

    International Nuclear Information System (INIS)

    Jayaraman, Raja; Colapinto, Cinzia; Torre, Davide La; Malik, Tufail

    2015-01-01

    Sustainable development requires implementing suitable policies integrating several competing objectives on economic, environmental, energy and social criteria. Multi-Criteria Decision Analysis (MCDA) using goal programming is a popular and widely used technique to study decision problems in the face of multiple conflicting objectives. MCDA assists policy makers by providing clarity in choosing between alternatives for strategic planning and investments. In this paper, we propose a weighted goal programming model that integrates efficient allocation of resources to simultaneously achieve sustainability related goals on GDP growth, electricity consumption and GHG emissions. We validate the model with application to key economic sectors of the United Arab Emirates to achieve sustainable development goals by the year 2030. The model solution provides a quantitative justification and a basis for comparison in planning future energy requirements and an indispensable requirement to include renewable sources to satisfy long-term energy requirements. - Highlights: • Multi-criteria model for achieving sustainability goals by year 2030. • Integrates criteria on electricity, GDP, GHG emissions for optimal labor allocation. • Future electricity demand requires contribution from renewable sources • Enables planning for long term investments towards energy sustainability.

  20. Applied high-speed imaging for the icing research program at NASA Lewis Research Center

    Science.gov (United States)

    Slater, Howard; Owens, Jay; Shin, Jaiwon

    1992-01-01

    The Icing Research Tunnel at NASA Lewis Research Center provides scientists a scaled, controlled environment to simulate natural icing events. The closed-loop, low speed, refrigerated wind tunnel offers the experimental capability to test for icing certification requirements, analytical model validation and calibration techniques, cloud physics instrumentation refinement, advanced ice protection systems, and rotorcraft icing methodology development. The test procedures for these objectives all require a high degree of visual documentation, both in real-time data acquisition and post-test image processing. Information is provided to scientific, technical, and industrial imaging specialists as well as to research personnel about the high-speed and conventional imaging systems will be on the recent ice protection technology program. Various imaging examples for some of the tests are presented. Additional imaging examples are available from the NASA Lewis Research Center's Photographic and Printing Branch.

  1. Implementation of a management applied program for liquid radioactive waste treatment

    International Nuclear Information System (INIS)

    Lee, Y. H.; Ann, S. J.; Jo, H. S.; Son, J. S.

    2003-01-01

    A data collection of a liquid radioactive waste treatment process of a research organization became necessary while developing the RAWMIS(Radioactive Waste Management Integration System) which it can generate personal history management for efficient management of a waste, documents, all kinds of statistics. This paper introduces an input and output application program design to do to database with data in the results and a stream process of a treatment that analyzed the waste occurrence present situation and data by treatment process. Data on the actual treatment process that is not limited experiment improve by a document, human traces, saving of material resources and improve with efficiency of tracking about a radioactive waste and a process and give help to radioactive waste material valance and inventory study

  2. Ecological Forecasting in the Applied Sciences Program and Input to the Decadal Survey

    Science.gov (United States)

    Skiles, Joseph

    2015-01-01

    Ecological forecasting uses knowledge of physics, ecology and physiology to predict how ecosystems will change in the future in response to environmental factors. Further, Ecological Forecasting employs observations and models to predict the effects of environmental change on ecosystems. In doing so, it applies information from the physical, biological, and social sciences and promotes a scientific synthesis across the domains of physics, geology, chemistry, biology, and psychology. The goal is reliable forecasts that allow decision makers access to science-based tools in order to project changes in living systems. The next decadal survey will direct the development Earth Observation sensors and satellites for the next ten years. It is important that these new sensors and satellites address the requirements for ecosystem models, imagery, and other data for resource management. This presentation will give examples of these model inputs and some resources needed for NASA to continue effective Ecological Forecasting.

  3. School Food Environment Promotion Program: Applying the Socio-ecological Approach

    Directory of Open Access Journals (Sweden)

    Fatemeh Bakhtari Aghdam

    2018-01-01

    Full Text Available Background Despite of healthy nutrition recommendations have been offered in recent decades, researches show an increasing rate of unhealthy junk food consumption among primary school children. The aim of this study was to investigate the effects of health promotion intervention on the school food buffets and the changes in nutritional behaviors of the students. Materials and Methods In this Quasi-interventional study, eight schools agreed to participate in Tabriz city, Iran. The schools were randomly selected and divided into an intervention and a control group, and a pretest was given to both groups. A four weeks interventional program was conducted in eight randomly selected schools of the city based on the socio-ecological model. A check list was designed for the assessment of food items available at the schools’ buffets, a 60-item semi-quantitative food frequency questionnaire (FFQ was used to assess the rate of food consumption and energy intake. Results evaluation and practice were analyzed using the Wilcoxon, Mann Whitney-U and Chi-square tests. Results The findings revealed reduction in the intervention group between before and after intervention with regard the range of junk food consumption, except for the sweets consumption. The number of junk foods provided in the schools buffets reduced in the intervention group. After the intervention on the intervention group significant decreases were found in the intake of energy, fat and saturated fatty acids compared to the control group (p = 0.00.   Conclusion In order to design effective school food environment promotion programs, school healthcare providers should consider multifaceted approaches.

  4. Stakeholder Participation in Freshwater Monitoring and Evaluation Programs: Applying Thresholds of Potential Concern within Environmental Flows

    Science.gov (United States)

    Conallin, John; McLoughlin, Craig A.; Campbell, Josh; Knight, Roger; Bright, Troy; Fisher, Ian

    2018-03-01

    The complex nature of freshwater systems provides challenges for incorporating evidence-based techniques into management. This paper investigates the potential of participatory evidence-based techniques to involve local stakeholders and make decisions based on different "knowledge" sources within adaptive management programs. It focuses on the application of thresholds of potential concern (TPC) within strategic adaptive management (SAM) for facilitating inclusive decision-making. The study is based on the case of the Edward-Wakool (E-W) "Fish and Flows" SAM project in the Murray-Darling River Basin, Australia. We demonstrate the application of TPCs for improving collaborative decision-making within the E-W, associated with environmental watering requirements, and other natural resource management programs such as fish stocking. The development of TPCs in the E-W fish and flows SAM project helped improve stakeholder involvement and understanding of the system, and also the effectiveness of the implemented management interventions. TPCs ultimately helped inform environmental flow management activities. The TPC process complemented monitoring that was already occurring in the system and provided a mechanism for linking formal and informal knowledge to form explicit and measurable endpoints from objectives. The TPC process faced challenges due to the perceived reduction in scientific rigor within initial TPC development and use. However, TPCs must remain tangible to managers and other stakeholders, in order to aid in the implementation of adaptive management. Once accepted by stakeholders, over time TPCs should be reviewed and refined in order to increase their scientific rigor, as new information is generated.

  5. Product traceability and quality as applied to the united states transuranic and high-level waste repository programs

    International Nuclear Information System (INIS)

    Pickering, S.Y.; Orrell, S.A.

    2000-01-01

    As with any repository program, predictions of the performance of a site over very long time frames may often meet with skepticism from the public and decision-makers, such as regulatory and governmental agencies. Experience at the WIPP and the YMP indicate that demonstrating the defensibility of data, conceptual models, computer codes, and numerical analyses is critical. Five overarching principles have been found to be the basis of a technically and publicly acceptable repository. The principles are traceability, transparency, reproducibility, retrievability, and reviews. - Traceability allows one to understand the source and justification of data and other input that generate conclusions. - Transparency allows one to follow the logic, calculations, and other operations that produce results. - Reproducibility allows one to reconstruct the results without recourse to the originator of the information. - Retrievability allows one to retrieve documentation that demonstrate these overarching principles. - Reviews ensure that the work is technically acceptable, complete, and accurate. This paper discusses how these principles are applied to the WIPP and the YMP. By setting up quality assurance and management controls (e.g., procedures, audits, peer reviews) these principles are implemented. Without successfully applying these principles the WIPP would not have gone from research to industrial maturity. The YMP is ensuring that these are implemented for activities that support licensing. Any repository program concerned with demonstrating defensibility to the public and regulators would do well by incorporating traceability, transparency, reproducibility, retrievability, and reviews into their program. (authors)

  6. Programmed death-ligand 1 expression correlates with diminished CD8+ T cell infiltration and predicts poor prognosis in anal squamous cell carcinoma patients

    Directory of Open Access Journals (Sweden)

    Zhao Y

    2017-12-01

    Full Text Available Yu-Jie Zhao,1 Wei-Peng Sun,2 Jian-Hong Peng,1 Yu-Xiang Deng,1 Yu-Jing Fang,1 Jun Huang,2 Hui-Zhong Zhang,3 De-Sen Wan,1 Jun-Zhong Lin,1,* Zhi-Zhong Pan,1,* 1Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 2Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, 3Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China *These authors contributed equally to this work Objective: Increased expression of programmed death-ligand 1 (PD-L1 on tumor cells can be found in various malignancies; however, very limited information is known about its role in anal squamous cell carcinoma (ASCC. This study explored PD-L1 expression in ASCC patients and its association with patients’ clinicopathological features, CD8+ T cell infiltration, and prognosis.Methods: Formalin-fixed paraffin-embedded tumor samples from 26 patients with ASCC were retrieved. The levels of PD-L1 expression on the membrane of both tumor cells and tumor-infiltrating mononuclear cells (TIMCs were evaluated by immunohistochemistry. CD8+ T cell densities, both within tumors and at the tumor–stromal interface, were also analyzed. Baseline clinicopathological characteristics, human papilloma virus (HPV status, and outcome data correlated with PD-L1-positive staining.Results: PD-L1 expression on tumor cells and TIMCs was observed in 46% and 50% of patients, respectively. Nineteen patients (73% were HPV positive, with 7 showing PD-L1-positive staining on tumor cells and 9 showing PD-L1-positive staining on TIMCs. Increasing CD8+ density within tumors, but not immune stroma, was significantly associated with decreased PD-L1 expression by both tumor cells and TIMCs (P=0.0043 and P=0.0007. Patients with negative PD-L1 expression had significantly better progression-free survival (P=0.038 and P

  7. CD sundials

    Science.gov (United States)

    Bokor, Nándor

    2018-01-01

    In this paper I present various equatorial sundial designs that use diffraction on a CD to display time. The designs described in the paper include a transparent CD sundial equipped with a small terrestrial globe. This sundial is compact, pedagogically useful, can be used throughout the year, and provides the user with a wealth of information.

  8. A mixed integer linear programming model applied in barge planning for Omya

    Directory of Open Access Journals (Sweden)

    David Bredström

    2015-12-01

    Full Text Available This article presents a mathematical model for barge transport planning on the river Rhine, which is part of a decision support system (DSS recently taken into use by the Swiss company Omya. The system is operated by Omya’s regional office in Cologne, Germany, responsible for distribution planning at the regional distribution center (RDC in Moerdijk, the Netherlands. The distribution planning is a vital part of supply chain management of Omya’s production of Norwegian high quality calcium carbonate slurry, supplied to European paper manufacturers. The DSS operates within a vendor managed inventory (VMI setting, where the customer inventories are monitored by Omya, who decides upon the refilling days and quantities delivered by barges. The barge planning problem falls into the category of inventory routing problems (IRP and is further characterized with multiple products, heterogeneous fleet with availability restrictions (the fleet is owned by third party, vehicle compartments, dependency of barge capacity on water-level, multiple customer visits, bounded customer inventories and rolling planning horizon. There are additional modelling details which had to be considered to make it possible to employ the model in practice at a sufficient level of detail. To the best of our knowledge, we have not been able to find similar models covering all these aspects in barge planning. This article presents the developed mixed-integer programming model and discusses practical experience with its solution. Briefly, it also puts the model into the context of the entire business case of value chain optimization in Omya.

  9. A Weighted Goal Programming model for planning sustainable development applied to Gulf Cooperation Council Countries

    International Nuclear Information System (INIS)

    Jayaraman, Raja; Colapinto, Cinzia; La Torre, Davide; Malik, Tufail

    2017-01-01

    Highlights: • Application of multi-criteria optimization model for sustainable development. • GHG emissions targets cannot be attainable due to reliance on hydrocarbon sources. • Provides quantitative evidence for future investments in green energy. • Application to Gulf Cooperation Countries. - Abstract: The United Nations agenda for sustainable development by the year 2030 proposes 17 sustainable development goals which include access to affordable, reliable and clean energy, sustained economic growth with full productive employment and, urgent action to mitigate environmental degradation. Planning for sustainable development requires integrating conflicting criteria on economy, energy, environment and social aspects. In this paper, we introduce a Weighted Goal Programming model involving criteria on the economic development (GDP), the electricity consumption, the greenhouse gas emissions, and the total number of employees to determine optimal labor allocation across various economic sectors. The proposed model is validated with data from the six members of the Gulf Cooperation Council (namely Bahrain, Kuwait, Oman, Qatar, Saudi Arabia and the United Arab Emirates). The results of the model aim to provide empirical evidence and insights to decision makers and policy analysts in developing optimal strategies able to simultaneously satisfy energy demand, economic growth, labor development and reduction in greenhouse gas emissions to achieve sustainability targets by the year 2030.

  10. Energy Programs at the Johns Hopkins University Applied Physics Laboratory, Quarterly Report, July-September 1980

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-09-01

    The Johns Hopkins University Applied Physics Laboratory, under contracts with several agencies of the federal government, is engaged in developing energy resources, utilization concepts, and monitoring and storage methods. This Quarterly Report summarizes the work on the various tasks as of 31 September 1980. The Energy Quarterly Report is divided into four sections. The first, Geothermal Energy Development Planning and Technical Assistance, supported by the Department of Energy/Division of Geothermal Energy (DOE/DGE), contains reports on the progress of geothermal-related tasks on which effort was concentrated during the quarter. The second section, Operational Research, Hydroelectric Power Development, supported by the Department of Energy/Resource Applications (DOE/RA), contains reports on small-scale hydroelectric investigations in the southeastern states. The third section, Seismotectonic Investigations, supported by the Reactor Safety Research Division of the Nuclear Regulatory Commission (NRC), reports on neotectonic investigations of the Manhattan Prong. The fourth section, Energy Conversion and Storage Techniques, contains three articles. The first is an evaluation of the Einstein refrigerator, supported by independent IR&D funds. The second concerns OTEC pilot plant performance calculations, supported by the Department of Energy/Division of Central Solar Technology (DOE/CST). The third, describing a study of landfill methane recovery, is supported by the National Park Service.

  11. Field manual for geohydrological sampling as applied to the radioactive waste disposal program

    International Nuclear Information System (INIS)

    Levin, M.

    1983-08-01

    This report serves as a manual for geohydrological sampling as practised by NUCOR's Geology Department. It discusses systematically all aspects concerned with sampling and stresses those where negligence has caused complications in the past. Accurate, neat and systematic procedures are emphasised. The report is intended as a reference work for the field technician. Analytical data on water samples provide an indication of the geohydrological processes taking place during the interaction between groundwater and the enclosing aquifers. It is possible to identify water bodies, using some of a multitude of parameters such as major ions, trace elements and isotopes which may give clues as to the origin, directions of flow and age of groundwater bodies. The South African Radioactive Waste Project also requires this information for determining the direction of migration of the radionuclides in the environment in the event of a spillage. The sampling procedures required for water, and in particular groundwater, must be applied in such a manner that the natural variation of dissolved species is not disturbed to any significant degree. With this in mind, the operator has to exercise meticulous care during initial preparation, collection, storing, preserving and handling of the water samples. This report is a field manual and describes the procedures adopted for the Radwaste Project geohydrological investigations in the Northwest Cape

  12. Energy Programs at the Johns Hopkins University Applied Physics Laboratory, Quarterly Report, January-March 1980

    Energy Technology Data Exchange (ETDEWEB)

    Entingh, Daniel J.

    1980-03-01

    The Johns Hopkins University Applied Physics Laboratory, under contracts with several agencies of the federal government and an agency of the State of Maryland, is engaged in developing energy resources, utilization concepts, and monitoring and storage methods. This Quarterly Report summarizes the work on the various tasks as of 31 March 1980. The Energy Quarterly Report is divided into four sections. The first, Geothermal Energy Development Planning and Technical Assistance, supported by the Department of Energy/Division of Geothermal Energy (DOE/DGE), contains reports on the progress of geothermal-related tasks on which effort was concentrated during the quarter. The second section, Operational Research, Hydroelectric Power Development, supported by the Department of Energy/Resource Applications (DOE/DGE), contains reports on small-scale hydroelectric investigations in the southeastern states. The third section, Seismotectonic Investigation, supported by the Reactor Safety Research Division of the Nuclear Regulatory Commission, reports on a neotectonic investigation in Connecticut. The fourth section, Energy Conversion and Storage Techniques, contains two articles, the first on OTEC core unit testing supported by the Department of Energy/Division of Central Solar Technology (DOE/CST), and the second on an analysis of the Community Annual Storage Energy System at the U.S. Naval Air Station, Norfolk, Va. This work is supported by the Department of Energy and the Department of Defense, Naval Facilities Engineering Command/Atlantic Division.

  13. Energy Programs at the Johns Hopkins University Applied Physics Laboratory, Quarterly Report, April-June 1980

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-06-01

    The Johns Hopkins University Applied Physics Laboratory, under contracts with several agencies of the federal government and an agency of the State of Maryland, is engaged in developing energy resources, utilization concepts, and monitoring and storage methods. This Quarterly Report summarizes the work on the various tasks as of 30 June 1980. The Energy Quarterly Report is divided into three sections. The first, Geothermal Energy Development Planning and Technical Assistance, supported by the Department of Energy/Division of Geothermal Energy (DOE/DGE), contains reports on the progress of geothermal-related tasks on which effort was concentrated during the quarter. The second section, Operational Research, Hydroelectric Power Development, supported by the Department of Energy/Resource Applications (DOE/RA), contains reports on small-scale hydroelectric investigations in the southeastern states. The third section, Energy Conversion and Storage Techniques, contains three articles. The first is on data analysis of OTEC core unit condenser tests, and is supported by the Department of Energy/Division of Central Solar Technology (DOE/CST). The second is on the current status of the Community Annual Storage Energy System at the U.S. Naval Air Station, Norfolk, Va., and is supported by the Department of Energy and the Department of Defense, Naval Facilities Engineering Command/Atlantic Division. The third is on utilization of landfill methane and is supported by Argonne National Laboratory.

  14. Applying Geospatial Technologies for International Development and Public Health: The USAID/NASA SERVIR Program

    Science.gov (United States)

    Hemmings, Sarah; Limaye, Ashutosh; Irwin, Dan

    2011-01-01

    Background: SERVIR -- the Regional Visualization and Monitoring System -- helps people use Earth observations and predictive models based on data from orbiting satellites to make timely decisions that benefit society. SERVIR operates through a network of regional hubs in Mesoamerica, East Africa, and the Hindu Kush-Himalayas. USAID and NASA support SERVIR, with the long-term goal of transferring SERVIR capabilities to the host countries. Objective/Purpose: The purpose of this presentation is to describe how the SERVIR system helps the SERVIR regions cope with eight areas of societal benefit identified by the Group on Earth Observations (GEO): health, disasters, ecosystems, biodiversity, weather, water, climate, and agriculture. This presentation will describe environmental health applications of data in the SERVIR system, as well as ongoing and future efforts to incorporate additional health applications into the SERVIR system. Methods: This presentation will discuss how the SERVIR Program makes environmental data available for use in environmental health applications. SERVIR accomplishes its mission by providing member nations with access to geospatial data and predictive models, information visualization, training and capacity building, and partnership development. SERVIR conducts needs assessments in partner regions, develops custom applications of Earth observation data, and makes NASA and partner data available through an online geospatial data portal at SERVIRglobal.net. Results: Decision makers use SERVIR to improve their ability to monitor air quality, extreme weather, biodiversity, and changes in land cover. In past several years, the system has been used over 50 times to respond to environmental threats such as wildfires, floods, landslides, and harmful algal blooms. Given that the SERVIR regions are experiencing increased stress under larger climate variability than historic observations, SERVIR provides information to support the development of

  15. Required Assets for a Nuclear Energy Applied R&D Program

    Energy Technology Data Exchange (ETDEWEB)

    Harold F. McFarlane; Craig L. Jacobson

    2009-03-01

    This report is one of a set of three documents that have collectively identified and recommended research and development capabilities that will be required to advance nuclear energy in the next 20 to 50 years. The first report, Nuclear Energy for the Future: Required Research and Development Capabilities—An Industry Perspective, was produced by Battelle Memorial Institute at the request of the Assistant Secretary of Nuclear Energy. That report, drawn from input by industry, academia, and Department of Energy laboratories, can be found in Appendix 5.1. This Idaho National Laboratory report maps the nuclear-specific capabilities from the Battelle report onto facility requirements, identifying options from the set of national laboratory, university, industry, and international facilities. It also identifies significant gaps in the required facility capabilities. The third document, Executive Recommendations for Nuclear R&D Capabilities, is a letter report containing a set of recommendations made by a team of senior executives representing nuclear vendors, utilities, academia, and the national laboratories (at Battelle’s request). That third report can be found in Appendix 5.2. The three reports should be considered as set in order to have a more complete picture. The basis of this report was drawn from three sources: previous Department of Energy reports, workshops and committee meetings, and expert opinion. The facilities discussed were winnowed from several hundred facilities that had previously been catalogued and several additional facilities that had been overlooked in past exercises. The scope of this report is limited to commercial nuclear energy and those things the federal government, or more specifically the Office of Nuclear Energy, should do to support its expanded deployment in order to increase energy security and reduce carbon emissions. In the context of this report, capabilities mean innovative, well-structured research and development programs

  16. The NASA Applied Science Program Disasters Area: Disaster Applications Research and Response

    Science.gov (United States)

    Murray, J. J.; Lindsay, F. E.; Stough, T.; Jones, C. E.

    2014-12-01

    The goal of the Natural Disaster Application Area is to use NASA's capabilities in spaceborne, airborne, surface observations, higher-level derived data products, and modeling and data analysis to improve natural disaster forecasting, mitigation, and response. The Natural Disaster Application Area applies its remote sensing observations, modeling and analysis capabilities to provide hazard and disaster information where and when it is needed. Our application research activities specifically contribute to 1) Understanding the natural processes that produce hazards, 2)Developing hazard mitigation technologies, and 3)Recognizing vulnerability of interdependent critical infrastructure. The Natural Disasters Application area selects research projects through a rigorous, impartial peer-review process that address a broad spectrum of disasters which afflict populations within the United States, regionally and globally. Currently there are 19 active projects in the research portfolio which address the detection, characterization, forecasting and response to a broad range of natural disasters including earthquakes, tsunamis, volcanic eruptions and ash dispersion, wildfires, hurricanes, floods, tornado damage assessment, oil spills and disaster data mining. The Disasters team works with federal agencies to aid the government in meeting the challenges associated with natural disaster response and to transfer technologies to agencies as they become operational. Internationally, the Disasters Area also supports the Committee on Earth Observations Working Group on Disasters, and the International Charter on Space and Disasters to increase, strengthen, and coordinate contributions of NASA Earth-observing satellites and applications products to disaster risk management. The CEOS group will lead pilot efforts focused on identifying key systems to support flooding, earthquake, and volcanic events.

  17. Overview of the Quality Assurance Program Applied to the Performance Assessment of the Waste Isolation Pilot Plant

    International Nuclear Information System (INIS)

    Pickering, S.Y.

    1999-01-01

    The Waste Isolation Pilot Plant (WIPP) is the first deep geologic repository for radioactive waste disposal in the world to be certified by a regulator. Rigorous, nuclear-industry quality assurance (QA) requirements were imposed by the US Environmental Protection Agency. As the Scientific Advisor to the US Department of Energy, Sandia National Laboratories applied these standards to the experimental studies and performance assessment used in the certification process. The QA program ensured that activities conducted by SNL were traceable, transparent, reviewed, reproducible, and retrievable. As a result, regulators and stakeholders were able to evaluate and ultimately certify and accept the WIPP

  18. Preventing Childhood Anxiety Disorders: Is an Applied Game as Effective as a Cognitive Behavioral Therapy-Based Program?

    Science.gov (United States)

    Schoneveld, Elke A; Lichtwarck-Aschoff, Anna; Granic, Isabela

    2018-02-01

    A large proportion of children experience subclinical levels of anxiety and cognitive-behavioral therapy (CBT) aimed at preventing anxiety disorders is moderately effective. However, most at-risk children do not seek help or drop out of programs prematurely because of stigma, lack of motivation, and accessibility barriers. Applied games have received increased attention as viable alternatives and have shown promising results, but direct comparisons between applied games and the gold-standard CBT are lacking. Our aim was to investigate whether the applied game MindLight is as effective as CBT (i.e., Coping Cat) within an indicated prevention context. We conducted a randomized controlled non-inferiority trial with a sample of 174 children (7- to 12-year olds) with elevated levels of anxiety, comparing MindLight to CBT. Anxiety was assessed with self- and parent-reports at pre- and post-program, and at 3- and 6-month follow-ups. Intention-to-treat and completers-only confidence interval approach and latent growth curve modeling showed an overall significant quadratic decrease in child- and parent-reported anxiety symptoms over time and, as predicted, the magnitude of improvement was the same for MindLight and CBT. The within-group effect sizes were small to medium at post-test (- 0.32 to - 0.63), and medium to large (- 0.60 to - 1.07) at 3- and 6-month follow-ups. Furthermore, MindLight and CBT were rated equally anxiety inducing, difficult, and appealing; CBT was rated as more relevant to daily life than MindLight. The current study adds to the growing research on applied games for mental health and shows that these games hold potential as alternative delivery models for evidence-based therapeutic techniques.

  19. An optimized multilayer structure of CdS layer for CdTe solar cells application

    International Nuclear Information System (INIS)

    Han Junfeng; Liao Cheng; Jiang Tao; Spanheimer, C.; Haindl, G.; Fu, Ganhua; Krishnakumar, V.; Zhao Kui; Klein, A.; Jaegermann, W.

    2011-01-01

    Research highlights: → Two different methods to prepare CdS films for CdTe solar cells. → A new multilayer structure of window layer for the CdTe solar cell. → Thinner CdS window layer for the solar cell than the standard CdS layer. → Higher performance of solar cells based on the new multilayer structure. - Abstract: CdS layers grown by 'dry' (close space sublimation) and 'wet' (chemical bath deposition) methods are deposited and analyzed. CdS prepared with close space sublimation (CSS) has better crystal quality, electrical and optical properties than that prepared with chemical bath deposition (CBD). The performance of CdTe solar cell based on the CSS CdS layer has higher efficiency than that based on CBD CdS layer. However, the CSS CdS suffers from the pinholes. And consequently it is necessary to prepare a 150 nm thin film for CdTe/CdS solar cell. To improve the performance of CdS/CdTe solar cells, a thin multilayer structure of CdS layer (∼80 nm) is applied, which is composed of a bottom layer (CSS CdS) and a top layer (CBD CdS). That bi-layer film can allow more photons to pass through it and significantly improve the short circuit current of the CdS/CdTe solar cells.

  20. Efektivitas Program CSR/CD dalam Pengentasan Kemiskinan: Studi terhadap Model Peran Perusahaan Geothermal di Jawa Barat

    Directory of Open Access Journals (Sweden)

    Dody Prayogo

    2012-01-01

    Full Text Available This study discusses model of measurement to assess the effectiveness of programs of corporate social responsibility (CSR held by corporation of mines, oil and gas, and geothermal in relation with poverty alleviation within the surrounding communities. The case study is conducted in a geothermal company in West Java. Results of study indicate that measurements of CSR should be developed in accordance with the scale of program, and should as well make use micro indicators which are relevant with elements of poverty. Also, the assessment should mainly be focused to the target group of beneficiaries. The role of corporation can be differentiated with the role of government in alleviating the poverty, and hence the effectiveness should be measured with micro indicators. In general, the significances of CSR program in poverty alleviation are high in the variables of effectivity and relevance, but low in variables of sustainability and empowerment. Programs of economic and infrastructure development are predominant than that other programs such as education and health.

  1. Expression of Programmed Death-Ligand 1 by Human Colonic CD90+ Stromal Cells Differs Between Ulcerative Colitis and Crohn’s Disease and Determines Their Capacity to Suppress Th1 Cells

    Directory of Open Access Journals (Sweden)

    Ellen J. Beswick

    2018-05-01

    Full Text Available Background and AimsThe role of programmed cell death protein 1 (PD-1 and its ligands in the dysregulation of T helper immune responses observed in the inflammatory bowel disease (IBD is unclear. Recently, a novel concept emerged that CD90+ colonic (myofibroblasts (CMFs, also known as stromal cells, act as immunosuppressors, and are among the key regulators of acute and chronic inflammation. The objective of this study was to determine if the level of the PD-1 ligands is changed in the IBD inflamed colonic mucosa and to test the hypothesis that changes in IBD-CMF-mediated PD-1 ligand-linked immunosuppression is a mechanism promoting the dysregulation of Th1 cell responses.MethodsTissues and cells derived from Crohn’s disease (CD, ulcerative colitis (UC, and healthy individuals (N were studied in situ, ex vivo, and in culture.ResultsA significant increase in programmed death-ligand 1 (PD-L1 was observed in the inflamed UC colonic mucosa when compared to the non-inflamed matched tissue samples, CD, and healthy controls. UC-CMFs were among the major populations in the colonic mucosa contributing to the enhanced PD-L1 expression. In contrast, PD-L1 expression was decreased in CD-CMFs. When compared to CD-CMFs and N-CMFs, UC-CMFs demonstrated stronger suppression of IL-2, Th1 transcriptional factor Tbet, and IFN-γ expression by CD3/CD28-activated CD4+ T cells, and this process was PD-L1 dependent. Similar observations were made when differentiated Th1 cells were cocultured with UC-CMFs. In contrast, CD-CMFs showed reduced capacity to suppress Th1 cell activity and addition of recombinant PD-L1 Fc to CD-CMF:T cell cocultures partially restored the suppression of the Th1 type responses.ConclusionWe present evidence showing that increased PD-L1 expression suppresses Th1 cell activity in UC. In contrast, loss of PD-L1 expression observed in CD contributes to the persistence of the Th1 inflammatory milieu in CD. Our data suggest that

  2. Two-step algorithm of generalized PAPA method applied to linear programming solution of dynamic matrix control

    International Nuclear Information System (INIS)

    Shimizu, Yoshiaki

    1991-01-01

    In recent complicated nuclear systems, there are increasing demands for developing highly advanced procedures for various problems-solvings. Among them keen interests have been paid on man-machine communications to improve both safety and economy factors. Many optimization methods have been good enough to elaborate on these points. In this preliminary note, we will concern with application of linear programming (LP) for this purpose. First we will present a new superior version of the generalized PAPA method (GEPAPA) to solve LP problems. We will then examine its effectiveness when applied to derive dynamic matrix control (DMC) as the LP solution. The approach is to aim at the above goal through a quality control of process that will appear in the system. (author)

  3. A software complex intended for constructing applied models and meta-models on the basis of mathematical programming principles

    Directory of Open Access Journals (Sweden)

    Михаил Юрьевич Чернышов

    2013-12-01

    Full Text Available A software complex (SC elaborated by the authors on the basis of the language LMPL and representing a software tool intended for synthesis of applied software models and meta-models constructed on the basis of mathematical programming (MP principles is described. LMPL provides for an explicit form of declarative representation of MP-models, presumes automatic constructing and transformation of models and the capability of adding external software packages. The following software versions of the SC have been implemented: 1 a SC intended for representing the process of choosing an optimal hydroelectric power plant model (on the principles of meta-modeling and 2 a SC intended for representing the logic-sense relations between the models of a set of discourse formations in the discourse meta-model.

  4. XRAY applied program package for calculation of electron-photon fields in the energy range of 1-1000 keV

    International Nuclear Information System (INIS)

    Lappa, A.V.; Khadyeva, Z.M.; Burmistrov, D.S.; Vasil'ev, O.N.

    1990-01-01

    The package of applied XRAY programs is intended for calculating the linear and fluctuation characteristics of photon and electron radiation fields in heterogeneous medium within 1-1000 keV energy range. The XRAY program package consists of moduli written in FORTRAN-IV and data files. 9 refs

  5. Program-level and contextual-level determinants of low-median CD4+ cell count in cohorts of persons initiating ART in eight sub-Saharan African countries.

    Science.gov (United States)

    Nash, Denis; Wu, Yingfeng; Elul, Batya; Hoos, David; El Sadr, Wafaa

    2011-07-31

    In sub-Saharan Africa, many patients initiate antiretroviral therapy (ART) at CD4 cell counts much lower than those recommended in national guidelines. We examined program-level and contextual-level factors associated with low median CD4 cell count at ART initiation in populations initiating ART. Multilevel analysis of aggregate and program-level service delivery data. We examined data on 1690 cohorts of patients initiating ART during 2004-2008 in eight sub-Saharan African countries. Cohorts with median CD4 less than 111 cells/μl (the lowest quartile) were classified as having low median CD4 cell count at ART initiation. Cohort information was combined with time-updated program-level data and subnational contextual-level data, and analyzed using multilevel models. The 1690 cohorts had median CD4 cell count of 136 cells/μl and included 121,504 patients initiating ART at 267 clinics. Program-level factors associated with low cohort median CD4 cell count included urban setting [adjusted odds ratio (AOR) 2.1; 95% confidence interval (CI) 1.3-3.3], lower provider-to-patient ratio (AOR 2.2; 95% CI 1.3-4.0), no PMTCT program (AOR 3.6; 95% CI 1.0-12.8), outreach services for ART patients only vs. both pre-ART and ART patients (AOR 2.4; 95% CI 1.5-3.9), fewer vs. more adherence support services (AOR 1.6; 95% CI 1.0-2.5), and smaller cohort size (AOR 2.5; 95% CI 1.4-4.5). Contextual-level factors associated with low cohort median CD4 cell count included initiating ART in areas where a lower proportion of the population heard of AIDS, tested for HIV recently, and a higher proportion believed 'limiting themselves to one HIV-uninfected sexual partner reduces HIV risk'. Determinants of CD4 cell count at ART initiation in populations initiating ART operate at multiple levels. Structural interventions targeting points upstream from ART initiation along the continuum from infection to diagnosis to care engagement are needed.

  6. Evaluating health inequity interventions: applying a contextual (external) validity framework to programs funded by the Canadian Health Services Research Foundation.

    Science.gov (United States)

    Phillips, Kaye; Müller-Clemm, Werner; Ysselstein, Margaretha; Sachs, Jonathan

    2013-02-01

    Including context in the measurement and evaluation of health in equity interventions is critical to understanding how events that occur in an intervention's environment might contribute to or impede its success. This study adapted and piloted a contextual validity assessment framework on a selection of health inequity-related programs funded by the Canadian Health Services Research Foundation (CHSRF) between 1998 and 2006. The two overarching objectives of this study were (1) to determine the relative amount and quality of attention given to conceptualizing, measuring and validating context within CHSRF funded research final reports related to health-inequity; and (2) to contribute evaluative evidence towards the incorporation of context into the assessment and measurement of health inequity interventions. The study found that of the 42/146 CHSRF programs and projects, judged to be related to health inequity 20 adequately reported on the conceptualization, measurement and validation of context. Amongst these health-inequity related project reports, greatest emphasis was placed on describing the socio-political and economical context over actually measuring and validating contextual evidence. Applying a contextual validity assessment framework was useful for distinguishing between the descriptive (conceptual) versus empirical (measurement and validation) inclusion of documented contextual evidence. Although contextual validity measurement frameworks needs further development, this study contributes insight into identifying funded research related to health inequities and preliminary criteria for assessing interventions targeted at specific populations and jurisdictions. This study also feeds a larger critical dialogue (albeit beyond the scope of this study) regarding the relevance and utility of using evaluative techniques for understanding how specific external conditions support or impede the successful implementation of health inequity interventions. Copyright

  7. 45 CFR 2522.950 - What requirements and qualifications apply if my program focuses on supplemental academic support...

    Science.gov (United States)

    2010-10-01

    ... program focuses on supplemental academic support activities other than tutoring? 2522.950 Section 2522.950... support activities other than tutoring? (a) If your program does not involve tutoring as defined in § 2522... SERVICE AMERICORPS PARTICIPANTS, PROGRAMS, AND APPLICANTS Program Management Requirements for Grantees...

  8. CD4 Counts at Entry to HIV Care in Mexico for Patients under the “Universal Antiretroviral Treatment Program for the Uninsured Population,” 2007–2014

    Science.gov (United States)

    Hernández-Romieu, Alfonso C.; del Rio, Carlos; Hernández-Ávila, Juan Eugenio; Lopez-Gatell, Hugo; Izazola-Licea, José Antonio; Uribe Zúñiga, Patricia; Hernández-Ávila, Mauricio

    2016-01-01

    In Mexico, public health services have provided universal access to antiretroviral therapy (ART) since 2004. For individuals receiving HIV care in public healthcare facilities, the data are limited regarding CD4 T-lymphocyte counts (CD4e) at the time of entry into care. Relevant population-based estimates of CD4e are needed to inform strategies to maximize the impact of Mexico’s national ART program, and may be applicable to other countries implementing universal HIV treatment programs. For this study, we retrospectively analyzed the CD4e of persons living with HIV and receiving care at state public health facilities from 2007 to 2014, comparing CD4e by demographic characteristics and the marginalization index of the state where treatment was provided, and assessing trends in CD4e over time. Our sample included 66,947 individuals who entered into HIV care between 2007 and 2014, of whom 79% were male. During the study period, the male-to-female ratio increased from 3.0 to 4.3, reflecting the country's HIV epidemic; the median age at entry decreased from 34 years to 32 years. Overall, 48.6% of individuals entered care with a CD4≤200 cells/μl, ranging from 42.2% in states with a very low marginalization index to 52.8% in states with a high marginalization index, and from 38.9% among individuals aged 18–29 to 56.5% among those older than 50. The adjusted geometric mean (95% confidence interval) CD4e increased among males from 135 (131,142) cells/μl in 2007 to 148 (143,155) cells/μl in 2014 (p-valuewomen, with a geometric mean of 178 (171,186) and 171 (165,183) in 2007 and 2014, respectively. There have been important gains in access to HIV care and treatment; however, late entry into care remains an important barrier in achieving optimal outcomes of ART in Mexico. The geographic, socioeconomic, and demographic differences observed reflect important inequities in timely access to HIV prevention, care, and treatment services, and highlight the need to develop

  9. Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load

    DEFF Research Database (Denmark)

    Kløverpris, Henrik N; McGregor, Reuben; McLaren, James E

    2014-01-01

    of differentiation on HIV-1-specific CD8+ T-cell populations(n = 128) spanning 11 different epitope targets. RESULTS: Expression levels of PD-1, but not CD244 or LAG-3, varied substantially across epitope specificities both within and between individuals. Differential expression of PD-1 on T-cell receptor (TCR...

  10. CD4+ type II NKT cells mediate ICOS and programmed death-1-dependent regulation of type 1 diabetes

    DEFF Research Database (Denmark)

    Kadri, Nadir; Korpos, Eva; Gupta, Shashank

    2012-01-01

    Type 1 diabetes (T1D) is a chronic autoimmune disease that results from T cell-mediated destruction of pancreatic ß cells. CD1d-restricted NKT lymphocytes have the ability to regulate immunity, including autoimmunity. We previously demonstrated that CD1d-restricted type II NKT cells, which carry ...

  11. Using Evaluation and Research Theory to Improve Programs in Applied Settings: An Interview with Thomas D. Cook.

    Science.gov (United States)

    Buescher, Thomas M.

    1986-01-01

    An interview with T. Cook, author of works on the use of research and evaluation theory and design, touches on such topics as practical evaluation, planning programs with evaluation or research design, and evaluation of programs for gifted students. (CL)

  12. Tratamiento acortado estrictamente supervisado para tuberculosis pulmonar Shortened directly observed treatment applied to the tuberculosis control program

    Directory of Open Access Journals (Sweden)

    Guadalupe del Carmen Alvarez-Gordillo

    1998-05-01

    Full Text Available Objetivo. Evaluar la posibilidad de aplicar el tratamiento acortado estrictamente supervisado (TAES en el Programa de Control de la Tuberculosis en Chiapas, México. Material y métodos. Se evaluó la eficacia y la eficiencia del tratamiento en una cohorte de pacientes con tuberculosis pulmonar confirmada por baciloscopía, que ingresaron a tratamiento con esquemas de autoadministración semisupervisión y estricta supervisión, de enero a junio de 1996. Resultados. La eficacia fue de 90.9. 97.7 y 100% para los esquemas de tratamiento autoadministrado, semisupervisado y TAES, respectivamente, mientras que la eficiencia fue de 68.1. 77.6 y 88.5% en el mismo orden. Conclusiones. Para la salud pública el TAES demostró ser la actividad más importante en el control de la tuberculosis, al elevar las tasas de curación y disminuir, por lo tanto, las fuentes de transmisión de la enfermedad.Objective. To evaluate the usefulness of the Shortened Directly Observed Treatment (DOT, S applied to the Tuberculosis Control Program in Chiapas, Mexico. Material and methods. The efficacy and efficiency of treatment was evaluated in a cohort of pulmonary tuberculosis patients confirmed by baciloscopy, who were subjected to treatment under one of three different regimes, self-administered. supervised and DOT,S from January to June 1996. Results. Efficacy was 90.9%, 97.7% and 100% for self-administered, supervised and DOT,S treatment, respectively. Efficiency was 68.1%, 77.6% and 88.5% in the same order Conclusions. For public health ends, the DOT,S proved to be the most efficient in the control of tuberculosis. since healing rates were increased and this reduces sources of disease transmission.

  13. Examining the Effect of Social Values Education Program Being Applied to Nursery School Students upon Acquiring Social Skills

    Science.gov (United States)

    Sapsaglam, Özkan; Ömeroglu, Esra

    2016-01-01

    This study was conducted in an attempt to develop Social Values Education Program aimed at nursery school students and examine the effect of Social Values Education Program upon the social skill acquisition of nursery school students. The effect of the education program that was developed within the scope of the study upon the social skill…

  14. The Nuclear CD-Rom

    International Nuclear Information System (INIS)

    James, J.Z.

    1993-01-01

    September 1992 will see the publication of the first open-quotes Nuclear CD-ROMclose quotes-a Compact Disk Read-Only Memory (CD-ROM) containing both the entire Evaluated Nuclear Data Files (ENDF) library and the Evaluated Nuclear Structure Data Files (ENSDF) library. The CD-ROM will also contain codes for processing and visualizing the data, and some nuclear physics codes to use the ENDF data. Finally, the data and program files will be accompanied by fully-formatted documentation that can be read on many different workstations and microcomputers

  15. Applying Marketing Concepts to Non-Profit/Educational Organizations: The Youth Professional’s Responsibilities in Program Marketing & Promotion

    Directory of Open Access Journals (Sweden)

    Keith G. Diem

    2008-12-01

    Full Text Available The degree of participation in community-based youth development programs is typically affected by both the recruitment and retention of participants. A review of literature over more than forty years revealed the value of marketing and promotion to the viability of a company, product, or organization and how it may contribute to company sales or an organization’s membership. This article is focused on the application of marketing concepts to a non-profit organization or educational program. Using a marketing approach to program development can result in improved program quality as well as increased enrollment. Utilizing marketing activities such as needs assessment will aide in ensuring the program remains current in meeting needs and interests of clientele, the community, and society. Promoting an accurate and relevant image is a key in making sure people realize the value of your program.

  16. Web Application Development by Applying the MVC and Table Data Gateway in the Annual Program Budget Management System

    OpenAIRE

    A. Medina-Santiago; A. Cisneros-Gómez; E. M. Melgar-Paniagua; G. B. Nango-Sólis; E. A. Moreno-López; M. E. Castellanos-Morales; D. B. Cantoral-Díaz; L. M. Blanco-Gonzalez

    2017-01-01

    This paper is the result of the development of the Web application to register the Annual Work Program, in which goals and actions are assigned the financial resources to manage the annual work program identified. In this paper, we have identified five types of users: the first is the Administrator, in charge of monitoring the goals programmed in the period, as well as the resource assigned to reach those goals; the second corresponds to the purchasing department who is in charge of contactin...

  17. The Role of Programmed Cell Death Ligand-1 (PD-L1/CD274) in the Development of Graft versus Host Disease

    Science.gov (United States)

    Al-Chaqmaqchi, Heevy; Sadeghi, Behnam; Abedi-Valugerdi, Manuchehr; Al-Hashmi, Sulaiman; Fares, Mona; Kuiper, Raoul; Lundahl, Joachim

    2013-01-01

    Programmed cell death ligand-1 (PD-L1/CD274) is an immunomodulatory molecule involved in cancer and complications of bone marrow transplantation, such as graft rejection and graft-versus-host disease. The present study was designed to assess the dynamic expression of this molecule after hematopoietic stem cell transplantation in relation to acute graft-versus-host disease. Female BALB/c mice were conditioned with busulfan and cyclophosphamide and transplanted with either syngeneic or allogeneic (male C57BL/6 mice) bone marrow and splenic cells. The expression of PD-L1 was evaluated at different time points employing qPCR, western blot and immunohistochemistry. Allogeneic- but not syngeneic-transplanted animals exhibited a marked up-regulation of PD-L1 expression in the muscle and kidney, but not the liver, at days 5 and 7 post transplantation. In mice transplanted with allogeneic bone marrow cells, the enhanced expression of PD-L1 was associated with high serum levels of IFNγ and TNFα at corresponding intervals. Our findings demonstrate that PD-L1 is differently induced and expressed after allogeneic transplantation than it is after syngeneic transplantation, and that it is in favor of target rather than non-target organs at the early stages of acute graft-versus-host disease. This is the first study to correlate the dynamics of PD-L1 at the gene-, protein- and activity levels with the early development of acute graft-versus-host disease. Our results suggest that the higher expression of PD-L1 in the muscle and kidney (non-target tissues) plays a protective role in skeletal muscle during acute graft-versus-host disease. PMID:23593203

  18. Quality assurance applied to Radiological Protection Program of CPHR - Centro de Proteccion Y Higiene de las Radiaciones

    International Nuclear Information System (INIS)

    Marrero Garcia, M.; Jova Sed, L.; Domenech Nieves, H.; Hernandez Sainz, A.

    2001-01-01

    The quality assurance in establishment that use ionizing radiation sources, is according to international recommendations of radiation protection programs. This work intends to present the experience of the Centro de Proteccion y Higiene de las Radiaciones (CPHR), in the implementation of requirements of quality in their Radiological Protection Program

  19. Applying Learning Analytics for Improving Students Engagement and Learning Outcomes in an MOOCS Enabled Collaborative Programming Course

    Science.gov (United States)

    Lu, Owen H. T.; Huang, Jeff C. H.; Huang, Anna Y. Q.; Yang, Stephen J. H.

    2017-01-01

    As information technology continues to evolve rapidly, programming skills become increasingly crucial. To be able to construct superb programming skills, the training must begin before college or even senior high school. However, when developing comprehensive training programmers, the learning and teaching processes must be considered. In order to…

  20. Using ePortfolios to Assess Applied and Collaborative Learning and Academic Identity in a Summer Research Program for Community College Students

    Science.gov (United States)

    Singer-Freeman, Karen; Bastone, Linda; Skrivanek, Joseph

    2016-01-01

    We evaluate the extent to which ePortfolios can be used to assess applied and collaborative learning and academic identity among community college students from underrepresented minority groups who participated in a summer research program. Thirty-eight students were evaluated by their research sponsor and two or three naïve faculty evaluators.…

  1. MODELING OF PATTERN FORMING PROCESS OF AUTOMATIC RADIO DIRECTION FINDER OF PHASE VHF IN THE DEVELOPMENT ENVIRONMENT OF LabVIEW APPLIED PROGRAMS

    Directory of Open Access Journals (Sweden)

    G. K. Aslanov

    2015-01-01

    Full Text Available In the article is developed the model demonstrating the forming process of pattern of antenna system of aerodrome quasidopler automatic radiodirection-finder station in the development environment of LabVIEW applied programs of National Instrument company. 

  2. Teaching Applied Behavior Analysis Knowledge Competencies to Direct-Care Service Providers: Outcome Assessment and Social Validation of a Training Program

    Science.gov (United States)

    Luiselli, James K.; Bass, Jennifer D.; Whitcomb, Sara A.

    2010-01-01

    Staff training is a critical performance improvement objective within behavioral health care organizations. This study evaluated a systematic training program for teaching applied behavior analysis knowledge competencies to newly hired direct-care employees at a day and residential habilitation services agency for adults with intellectual and…

  3. Acceptability and preliminary feasibility of an internet/CD-ROM-based education and decision program for early-stage prostate cancer patients: randomized pilot study.

    Science.gov (United States)

    Diefenbach, Michael A; Mohamed, Nihal E; Butz, Brian P; Bar-Chama, Natan; Stock, Richard; Cesaretti, Jamie; Hassan, Waleed; Samadi, David; Hall, Simon J

    2012-01-13

    Prostate cancer is the most common cancer affecting men in the United States. Management options for localized disease exist, yet an evidence-based criterion standard for treatment still has to emerge. Although 5-year survival rates approach 98%, all treatment options carry the possibility for significant side effects, such as erectile dysfunction and urinary incontinence. It is therefore recommended that patients be actively involved in the treatment decision process. We have developed an Internet/CD-ROM-based multimedia Prostate Interactive Educational System (PIES) to enhance patients' treatment decision making. PIES virtually mirrors a health center to provide patients with information about prostate cancer and its treatment through an intuitive interface, using videos, animations, graphics, and texts. (1) To examine the acceptability and feasibility of the PIES intervention and to report preliminary outcomes of the program in a pilot trial among patients with a new prostate cancer diagnosis, and (2) to explore the potential impact of tailoring PIES treatment information to participants' information-seeking styles on study outcomes. Participants (n = 72) were patients with newly diagnosed localized prostate cancer who had not made a treatment decision. Patients were randomly assigned to 3 experimental conditions: (1) control condition (providing information through standard National Cancer Institute brochures; 26%), and PIES (2) with tailoring (43%) and (3) without tailoring to a patient's information-seeking style (31%). Questionnaires were administrated before (t1) and immediately after the intervention (t2). Measurements include evaluation and acceptability of the PIES intervention, monitoring/blunting information-seeking style, psychological distress, and decision-related variables (eg, decisional confidence, feeling informed about prostate cancer and treatment, and treatment preference). The PIES program was well accepted by patients and did not interfere

  4. [Effects of Self-management Program applying Dongsasub Training on Self-efficacy, Self-esteem, Self-management Behavior and Blood Pressure in Older Adults with Hypertension].

    Science.gov (United States)

    Kim, Myoungsuk; Song, Misoon

    2015-08-01

    The purpose of this study was to develop a self-management program applying Dongsasub training based on self-efficacy theory, and to verify the program effectiveness on self-esteem as well as self-efficacy, self-management behaviors, and blood pressure. The study design was a non-equivalent, pre-post controlled quasi-experiment study. Thirty-eight patients aged 65 and older from a senior welfare center in Seoul participated in this study (20 patients in the experimental group and 18 patients in the control group). The self-management program applying Dongsasub training consisted of eight sessions. After development was complete the program was used with the experimental group. Outcome variables included self-efficacy, self-esteem, self-management behaviors measured by questionnaires, and blood pressure measured by electronic manometer. Self-efficacy (t=2.42, p=.021), self-esteem (t=2.57, p=.014) and self-management behaviors (t=2.21, p=.034) were significantly higher and systolic blood pressure (t=-2.14, p=.040) was significantly lower in the experimental group compared to the control group. However, diastolic blood pressure (t=-.85, p=.400) was not significantly different between the two groups. The results indicate that the self-management program applying Dongsasub training can be used as a nursing intervention in community settings for improving self-management behaviors for older adults with hypertension.

  5. Applied optics

    International Nuclear Information System (INIS)

    Orszag, A.; Antonetti, A.

    1988-01-01

    The 1988 progress report, of the Applied Optics laboratory, of the (Polytechnic School, France), is presented. The optical fiber activities are focused on the development of an optical gyrometer, containing a resonance cavity. The following domains are included, in the research program: the infrared laser physics, the laser sources, the semiconductor physics, the multiple-photon ionization and the nonlinear optics. Investigations on the biomedical, the biological and biophysical domains are carried out. The published papers and the congress communications are listed [fr

  6. The Office Guidelines Applied to Practice program improves secondary prevention of heart disease in Federally Qualified Healthcare Centers

    Directory of Open Access Journals (Sweden)

    Adesuwa Olomu

    2016-12-01

    Office-GAP resulted in increased use of guideline-based medications for secondary CVD prevention in underserved populations. The Office-GAP program could serve as a model for implementing guideline-based care for other chronic diseases.

  7. Community and species-specific responses of wild bees to insect pest control programs applied to a pollinator-dependent crop.

    Science.gov (United States)

    Tuell, Julianna K; Isaacs, Rufus

    2010-06-01

    Wild bee conservation is regarded as essential for sustainable production of pollinator-dependent crops, yet little is known about the effects on wild bee communities of typical insect pest management programs used postbloom. We developed an insecticide program risk (IPR) index to quantify the relative risk to wild bees of insecticide programs applied to blueberry fields. This was used to determine the relationship between IPR and the abundance, diversity, and richness of wild bee communities sampled during three successive flowering seasons. In 2 of 3 yr, bee abundance and species richness declined with increasing IPR. Bee diversity declined with IPR in one of 3 yr. These results indicate that wild bee communities are negatively affected by increasingly intensive chemical pest management activities in crop fields and that interyear variability in bee populations has the potential to mask such effects in short-term studies. When several wild bee species were analyzed separately, two of three solitary and one of three social blueberry-foraging species declined with increasing IPR values, suggesting that different life histories and nesting habits may help some bee populations escape the negative effects of insecticides applied after bloom. Pollinator conservation programs aimed strictly at reducing insecticide use may have varying success, depending on the biology of the target bee species. The IPR index provides a standard method to compare pest management programs for their potential effect on wild bee communities, with broad application for use in other agricultural systems.

  8. Applying economic incentives to increase effectiveness of an outpatient weight loss program (TRIO) - A randomized controlled trial.

    Science.gov (United States)

    Finkelstein, Eric A; Tham, Kwang-Wei; Haaland, Benjamin A; Sahasranaman, Aarti

    2017-07-01

    The prevalence of overweight and obesity has more than doubled in the past three decades, leading to rising rates of non-communicable diseases. This study tests whether adding a payment/rewards (term reward) program to an existing evidence-based weight loss program can increase weight loss and weight loss maintenance. We conducted a parallel-group randomized controlled trial from October 2012 to October 2015 with 161 overweight or obese individuals randomized to either control or reward arm in a 1:2 ratio. Control and reward arm participants received a four month weight loss program at the LIFE (Lifestyle Improvement and Fitness Enhancement) Centre at Singapore General Hospital. Those in the reward arm paid a fee of S$165.00 (1US$ = 1.35S$) to access a program that provided rewards of up to S$660 for meeting weight loss and physical activity goals. Participants could choose to receive rewards as guaranteed cash payments or a lottery ticket with a 1 in 10 chance of winning but with the same expected value. The primary outcome was weight loss at months 4, 8, and 12. 161 participants were randomized to control (n = 54) or reward (n = 107) arms. Average weight loss was more than twice as great in the reward arm compared to the control arm at month 4 when the program concluded (3.4 kg vs 1.4 kg, p rewards concluded (3.3 kg vs 1.8 kg, p rewards program can be used to improve weight loss and weight loss maintenance when combined with an evidence-based weight loss program. Future efforts should attempt to replicate this approach and identify how to cost effectively expand these programs to maximize their reach. This study is registered at www.clinicaltrials.gov (Identifier: NCT01533454). Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Calculation of self-shielding factors for cross-sections in the unresolved resonance region using the GRUCON applied program package

    International Nuclear Information System (INIS)

    Sinitsa, V.V.

    1984-11-01

    The author gives a scheme for the calculation of the self-shielding factors in the unresolved resonance region using the GRUCON applied program package. This package is especially created to be used in the conversion of evaluated neutron cross-section data, as available in existing data libraries, into multigroup microscopic constants. A detailed description of the formulae and algorithms used in the programs is given. Some typical examples of calculation are considered and the results are compared with those of other authors. The calculation accuracy is better than 2%

  10. 2005 Mississippi Curriculum Framework: Secondary Horticulture. (Program CIP: 01.0601 - Applied Horticulture/Horticultural Operations, General)

    Science.gov (United States)

    Research and Curriculum Unit, 2005

    2005-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  11. 31 CFR 205.25 - How does this part apply to certain Federal assistance programs or funds?

    Science.gov (United States)

    2010-07-01

    ... from its account in the UTF equals the actual interest earned on such funds less the related banking... account in the UTF are commingled with other funds, a proportionate share of interest earnings and banking... interest on Special Supplemental Food Program for Women, Infants, and Children rebates is not subject to...

  12. Preventing childhood anxiety disorders: Is an applied game as effective as a cognitive behavioral therapy-based program?

    NARCIS (Netherlands)

    Schoneveld, E.A.; Lichtwarck-Aschoff, A.; Granic, I.

    2018-01-01

    A large proportion of children experience subclinical levels of anxiety and cognitive-behavioral therapy (CBT) aimed at preventing anxiety disorders is moderately effective. However, most at-risk children do not seek help or drop out of programs prematurely because of stigma, lack of motivation, and

  13. "Who Was 'Shadow'?" The Computer Knows: Applying Grammar-Program Statistics in Content Analyses to Solve Mysteries about Authorship.

    Science.gov (United States)

    Ellis, Barbara G.; Dick, Steven J.

    1996-01-01

    Employs the statistics-documentation portion of a word-processing program's grammar-check feature together with qualitative analyses to determine that Henry Watterson, long-time editor of the "Louisville Courier-Journal," was probably the South's famed Civil War correspondent "Shadow." (TB)

  14. Methodology and computer program for applying improved, inelastic ERR for the design of mine layouts on planar reefs.

    CSIR Research Space (South Africa)

    Spottiswoode, SM

    2002-08-01

    Full Text Available and the visco-plastic models of Napier and Malan (1997) and Malan (2002). Methodologies and a computer program (MINF) are developed during this project that write synthetic catalogues of seismic events to simulate the rock response to mining...

  15. 34 CFR 664.5 - What definitions apply to the Fulbright-Hays Group Projects Abroad Program?

    Science.gov (United States)

    2010-07-01

    ..., including the study of their geography, history, culture, economy, politics, international relations, and...: Applicant Application Award EDGAR Equipment Facilities Grant Grantee Nonprofit Project Private Public... than a two-year program which is acceptable for full credit toward such a degree; (4) Is a public or...

  16. For the Love of Statistics: Appreciating and Learning to Apply Experimental Analysis and Statistics through Computer Programming Activities

    Science.gov (United States)

    Mascaró, Maite; Sacristán, Ana Isabel; Rufino, Marta M.

    2016-01-01

    For the past 4 years, we have been involved in a project that aims to enhance the teaching and learning of experimental analysis and statistics, of environmental and biological sciences students, through computational programming activities (using R code). In this project, through an iterative design, we have developed sequences of R-code-based…

  17. Implementation and Sustainability of an Evidence-Based Program: Lessons Learned from the Prism Applied to "First Step to Success"

    Science.gov (United States)

    Woodbridge, Michelle W.; Sumi, W. Carl; Yu, Jennifer; Rouspil, Kristen; Javitz, Harold S.; Seeley, John R.; Walker, Hill M.

    2014-01-01

    Although numerous studies address the efficacy of school-based interventions, fewer focus on how to support sustainability of interventions from the perspective of participants. To address this research gap, we use the Practical, Robust Implementation and Sustainability Model to examine how the characteristics of an evidence-based program interact…

  18. GLYCOHEMOGLOBIN - COMPARISON OF 12 ANALYTICAL METHODS, APPLIED TO LYOPHILIZED HEMOLYSATES BY 101 LABORATORIES IN AN EXTERNAL QUALITY ASSURANCE PROGRAM

    NARCIS (Netherlands)

    WEYKAMP, CW; PENDERS, TJ; MUSKIET, FAJ; VANDERSLIK, W

    Stable lyophilized ethylenediaminetetra-acetic acid (EDTA)-blood haemolysates were applied in an external quality assurance programme (SKZL, The Netherlands) for glycohaemoglobin assays in 101 laboratories using 12 methods. The mean intralaboratory day-to-day coefficient of variation (CV),

  19. Applying Learner-Centered Principles to Teaching Human Behavior in the Social Environment in a Baccalaureate Program

    Science.gov (United States)

    Karolich, Robert; Ford, Janet

    2013-01-01

    Changes in the demographics of American undergraduate students must be addressed by changes in delivery of the curriculum. The learner-centered approach to education helps to recognize and integrate student diversity with class exercises and assignments designed to help students meet course learning outcomes. This article applies the American…

  20. A new 2D segmentation method based on dynamic programming applied to computer aided detection in mammography

    International Nuclear Information System (INIS)

    Timp, Sheila; Karssemeijer, Nico

    2004-01-01

    Mass segmentation plays a crucial role in computer-aided diagnosis (CAD) systems for classification of suspicious regions as normal, benign, or malignant. In this article we present a robust and automated segmentation technique--based on dynamic programming--to segment mass lesions from surrounding tissue. In addition, we propose an efficient algorithm to guarantee resulting contours to be closed. The segmentation method based on dynamic programming was quantitatively compared with two other automated segmentation methods (region growing and the discrete contour model) on a dataset of 1210 masses. For each mass an overlap criterion was calculated to determine the similarity with manual segmentation. The mean overlap percentage for dynamic programming was 0.69, for the other two methods 0.60 and 0.59, respectively. The difference in overlap percentage was statistically significant. To study the influence of the segmentation method on the performance of a CAD system two additional experiments were carried out. The first experiment studied the detection performance of the CAD system for the different segmentation methods. Free-response receiver operating characteristics analysis showed that the detection performance was nearly identical for the three segmentation methods. In the second experiment the ability of the classifier to discriminate between malignant and benign lesions was studied. For region based evaluation the area A z under the receiver operating characteristics curve was 0.74 for dynamic programming, 0.72 for the discrete contour model, and 0.67 for region growing. The difference in A z values obtained by the dynamic programming method and region growing was statistically significant. The differences between other methods were not significant

  1. Implementing shared decision making in federally qualified health centers, a quasi-experimental design study: the Office-Guidelines Applied to Practice (Office-GAP) program

    OpenAIRE

    Olomu, Adesuwa; Hart-Davidson, William; Luo, Zhehui; Kelly-Blake, Karen; Holmes-Rovner, Margaret

    2016-01-01

    Background Use of Shared Decision-Making (SDM) and Decision Aids (DAs) has been encouraged but is not regularly implemented in primary care. The Office-Guidelines Applied to Practice (Office-GAP) intervention is an application of a previous model revised to address guidelines based care for low-income populations with diabetes and coronary heart disease (CHD). Objective: To evaluate Office-GAP Program feasibility and preliminary efficacy on medication use, patient satisfaction with physician ...

  2. NODC Standard Product: Coastal Change Analysis Program (C-CAP) Chesapeake Bay Region Data from 1984 to 1989 on CD-ROM (NODC Accession 9200303)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The data set on this CD-ROM shows changes in land cover for the Chesapeake Bay region over the 5-year interval from 1984 to 1988-89. The data set was produced...

  3. Project-based learning applied to spacecraft power systems: a long-term engineering and educational program at UPM University

    Science.gov (United States)

    Pindado, Santiago; Cubas, Javier; Roibás-Millán, Elena; Sorribes-Palmer, Félix

    2018-03-01

    The IDR/UPM Institute is the research center responsible for the Master in Space Systems (MUSE) of Universidad Politécnica de Madrid (UPM). This is a 2-year (120 ECTS) master's degree focused on space technology. The UPMSat-2 satellite program has become an excellent educational framework in which the academic contents of the master are trained through project-based learning and following a multidisciplinary approach. In the present work, the educational projects developed and carried out in relation to spacecraft power systems at the IDR/UPM Institute are described. These projects are currently being developed in the framework represented by the aforementioned MUSE master's program and UPMSat-2.

  4. Are We There Yet? Applying Thermodynamic and Kinetic Profiling on Embryonic Ectoderm Development (EED) Hit-to-Lead Program.

    Science.gov (United States)

    Wang, Ying; Edalji, Rohinton P; Panchal, Sanjay C; Sun, Chaohong; Djuric, Stevan W; Vasudevan, Anil

    2017-10-26

    It is advocated that kinetic and thermodynamic profiling of bioactive compounds should be incorporated and utilized as complementary tools for hit and lead optimizations in drug discovery. To assess their applications in the EED hit-to-lead optimization process, large amount of thermodynamic and kinetic data were collected and analyzed via isothermal titration calorimetry (ITC) and surface plasmon resonance (SPR), respectively. Slower dissociation rates (k off ) of the lead compounds were observed as the program progressed. Analysis of the kinetic data indicated that compound cellular activity correlated with both K i and k off . Our analysis revealed that ITC data should be interpreted in the context of chiral purity of the compounds. The thermodynamic signatures of the EED aminopyrrolidine compounds were found to be mainly enthalpy driven with improved enthalpic contributions as the program progressed. Our study also demonstrated that significant challenges still exist in utilizing kinetic and thermodynamic parameters for hit selection.

  5. PCARRD`s strategies for technology transfer: The agriculture and resources regional technology information system and the regional applied communication program

    Energy Technology Data Exchange (ETDEWEB)

    Stuart, T H; Mamon, C R [Philippine Council for Agriculture, Los Banos, Laguna (Philippines). Forestry and Natural Resources

    1990-05-01

    This paper describes the Agriculture and Resources Regional Technology Information System (ARRTIS) and the Regional Applied Communication Outreach Program (RAC) of PCARRD. The ARRTIS and the RACO are the strategies in communicating scientific and technology-based information. The ARRTIS is an information system that provides an information base on the status of technologies at various levels of maturity (generation, adaptation, verification, piloting, dissemination and utilization) and offers technology alternatives based on environmental requirements, costs and returns analysis or feasibility of the technologies. This information base provides the repository of technology information from which the Applied Communication Program draws its information for packaging into various formats, using various strategies/media to cater to various users in the regions most especially the farmers. Meanwhile, as PCARRD executes its mission of developing the national research system, it incorporates a development support communication program through the RACO. The RACO is essentially a working component of a regional research center/consortium in each region coordinated by the Applied Communication Division of PCARRD. It aims at reaching farmers and their families, extensionists, administrators, policy makers and entrepreneurs with research information and technology which use a variety of appropriate communication channels, modern communication technology and strategies so that they may actively participate in research diffusion and utilization. (author). 7 refs.

  6. Using Technology to Expand and Enhance Applied Behavior Analysis Programs for Children with Autism in Military Families

    Science.gov (United States)

    2016-07-01

    Nebraska Medical Center in Omaha). These trained parents will then be able to implement effective behavior management and teaching strategies with... parents . Interventions based on applied behavior analysis are well documented, but unfortunately these services are often not available to military...availability of this effective treatment. The fifth year of the award involved the continued recruitment of families with a child with an ASD to

  7. Effectiveness of a first-aid intervention program applied by undergraduate nursing students to preparatory school children.

    Science.gov (United States)

    Wafik, Wagida; Tork, Hanan

    2014-03-01

    Childhood injuries constitute a major public health problem worldwide. First aid is an effective life-preservation tool at work, school, home, and in public locations. In this study, the effectiveness of a first-aid program delivered by undergraduate nursing students to preparatory school children was examined. This quasi-experimental study was carried out on 100 school children in governmental preparatory schools in Egypt. The researchers designed a program for first-aid training, and this was implemented by trained nursing students. The evaluation involved immediate post-test and follow-up assessment after two months. The results showed generally low levels of satisfactory knowledge and inadequate situational practice among the school students before the intervention. Statistically-significant improvements were shown at the post- and follow-up tests. Multivariate regression analysis identified the intervention and the type of school as the independent predictors of the change in students' knowledge score, while the intervention and the knowledge score were the predictors of the practice score. The study concluded that a first-aid training program delivered by nursing students to preparatory school children is effective in improving their knowledge and practice. © 2013 Wiley Publishing Asia Pty Ltd.

  8. A viral long terminal repeat expressed in CD4+CD8+ precursors is downregulated in mature peripheral CD4-CD8+ or CD4+CD8- T cells.

    OpenAIRE

    Paquette, Y; Doyon, L; Laperrière, A; Hanna, Z; Ball, J; Sekaly, R P; Jolicoeur, P

    1992-01-01

    The long terminal repeat from a thymotropic mouse mammary tumor virus variant, DMBA-LV, was used to drive the expression of two reporter genes, murine c-myc and human CD4, in transgenic mice. Expression was observed specifically in thymic immature cells. Expression of c-myc in these cells induced oligoclonal CD4+ CD8+ T-cell thymomas. Expression of human CD4 was restricted to thymic progenitor CD4- CD8- and CD4+ CD8+ T cells and was shut off in mature CD4+ CD8- and CD4- CD8+ T cells, known to...

  9. Radiation protection program applied to occupationally exposed individuals at the IPEN/CNEN-SP pilot plant in the 1980s for natural uranium compounds

    International Nuclear Information System (INIS)

    Silva, Teresinha de Moraes da; Sordi, Gian Maria A.A.; Vasques, Francisco Mário Feijó

    2017-01-01

    The work evidences the chemical processing of natural uranium from the yellowcake phase to the production of UF 6 natural uranium hexafluoride, a process carried out at the IPEN/CNEN-SP pilot plant. Radiation protection management was intended to monitor occupationally exposed individuals - IOEs, the workplace and the environment. An individual monitoring program for IOEs was developed for both external irradiation and incorporation of radioactive material. The IOEs were monitored externally with film-type dosimeters and the in vitro method was applied internally for urine analysis. For the workplace the monitoring program for equipment and floors was developed, determining the exposure rate from the process equipment, surface contamination expressed in Bq.cm -2 in equipment and floors, complemented by the air monitoring program both for the worker as well as for the workplace. Cellulose filters with aerodynamic diameter of 0.3 micron to 8.0 micron were used

  10. Applying Various Methods of Communicating Science for Community Decision-Making and Public Awareness: A NASA DEVELOP National Program Case Study

    Science.gov (United States)

    Miller, T. N.; Brumbaugh, E. J.; Barker, M.; Ly, V.; Schick, R.; Rogers, L.

    2015-12-01

    The NASA DEVELOP National Program conducts over eighty Earth science projects every year. Each project applies NASA Earth observations to impact decision-making related to a local or regional community concern. Small, interdisciplinary teams create a methodology to address the specific issue, and then pass on the results to partner organizations, as well as providing them with instruction to continue using remote sensing for future decisions. Many different methods are used by individual teams, and the program as a whole, to communicate results and research accomplishments to decision-makers, stakeholders, alumni, and the general public. These methods vary in scope from formal publications to more informal venues, such as social media. This presentation will highlight the communication techniques used by the DEVELOP program. Audiences, strategies, and outlets will be discussed, including a newsletter, microjournal, video contest, and several others.

  11. Design of problem-specific evolutionary algorithm/mixed-integer programming hybrids: two-stage stochastic integer programming applied to chemical batch scheduling

    Science.gov (United States)

    Urselmann, Maren; Emmerich, Michael T. M.; Till, Jochen; Sand, Guido; Engell, Sebastian

    2007-07-01

    Engineering optimization often deals with large, mixed-integer search spaces with a rigid structure due to the presence of a large number of constraints. Metaheuristics, such as evolutionary algorithms (EAs), are frequently suggested as solution algorithms in such cases. In order to exploit the full potential of these algorithms, it is important to choose an adequate representation of the search space and to integrate expert-knowledge into the stochastic search operators, without adding unnecessary bias to the search. Moreover, hybridisation with mathematical programming techniques such as mixed-integer programming (MIP) based on a problem decomposition can be considered for improving algorithmic performance. In order to design problem-specific EAs it is desirable to have a set of design guidelines that specify properties of search operators and representations. Recently, a set of guidelines has been proposed that gives rise to so-called Metric-based EAs (MBEAs). Extended by the minimal moves mutation they allow for a generalization of EA with self-adaptive mutation strength in discrete search spaces. In this article, a problem-specific EA for process engineering task is designed, following the MBEA guidelines and minimal moves mutation. On the background of the application, the usefulness of the design framework is discussed, and further extensions and corrections proposed. As a case-study, a two-stage stochastic programming problem in chemical batch process scheduling is considered. The algorithm design problem can be viewed as the choice of a hierarchical decision structure, where on different layers of the decision process symmetries and similarities can be exploited for the design of minimal moves. After a discussion of the design approach and its instantiation for the case-study, the resulting problem-specific EA/MIP is compared to a straightforward application of a canonical EA/MIP and to a monolithic mathematical programming algorithm. In view of the

  12. Applying the elaboration likelihood model of persuasion to a videotape-based eating disorders primary prevention program for adolescent girls.

    Science.gov (United States)

    Withers, Giselle F; Wertheim, Eleanor H

    2004-01-01

    This study applied principles from the Elaboration Likelihood Model of Persuasion to the prevention of disordered eating. Early adolescent girls watched either a preventive videotape only (n=114) or video plus post-video activity (verbal discussion, written exercises, or control discussion) (n=187); or had no intervention (n=104). Significantly more body image and knowledge improvements occurred at post video and follow-up in the intervention groups compared to no intervention. There were no outcome differences among intervention groups, or between girls with high or low elaboration likelihood. Further research is needed in integrating the videotape into a broader prevention package.

  13. A situational analysis methodology to inform comprehensive HIV prevention and treatment programming, applied in rural South Africa.

    Science.gov (United States)

    Treves-Kagan, Sarah; Naidoo, Evasen; Gilvydis, Jennifer M; Raphela, Elsie; Barnhart, Scott; Lippman, Sheri A

    2017-09-01

    Successful HIV prevention programming requires engaging communities in the planning process and responding to the social environmental factors that shape health and behaviour in a specific local context. We conducted two community-based situational analyses to inform a large, comprehensive HIV prevention programme in two rural districts of North West Province South Africa in 2012. The methodology includes: initial partnership building, goal setting and background research; 1 week of field work; in-field and subsequent data analysis; and community dissemination and programmatic incorporation of results. We describe the methodology and a case study of the approach in rural South Africa; assess if the methodology generated data with sufficient saturation, breadth and utility for programming purposes; and evaluate if this process successfully engaged the community. Between the two sites, 87 men and 105 women consented to in-depth interviews; 17 focus groups were conducted; and 13 health facilities and 7 NGOs were assessed. The methodology succeeded in quickly collecting high-quality data relevant to tailoring a comprehensive HIV programme and created a strong foundation for community engagement and integration with local health services. This methodology can be an accessible tool in guiding community engagement and tailoring future combination HIV prevention and care programmes.

  14. Getting To Exascale: Applying Novel Parallel Programming Models To Lab Applications For The Next Generation Of Supercomputers

    Energy Technology Data Exchange (ETDEWEB)

    Dube, Evi [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Shereda, Charles [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Nau, Lee [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Harris, Lance [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2010-09-27

    As supercomputing moves toward exascale, node architectures will change significantly. CPU core counts on nodes will increase by an order of magnitude or more. Heterogeneous architectures will become more commonplace, with GPUs or FPGAs providing additional computational power. Novel programming models may make better use of on-node parallelism in these new architectures than do current models. In this paper we examine several of these novel models – UPC, CUDA, and OpenCL –to determine their suitability to LLNL scientific application codes. Our study consisted of several phases: We conducted interviews with code teams and selected two codes to port; We learned how to program in the new models and ported the codes; We debugged and tuned the ported applications; We measured results, and documented our findings. We conclude that UPC is a challenge for porting code, Berkeley UPC is not very robust, and UPC is not suitable as a general alternative to OpenMP for a number of reasons. CUDA is well supported and robust but is a proprietary NVIDIA standard, while OpenCL is an open standard. Both are well suited to a specific set of application problems that can be run on GPUs, but some problems are not suited to GPUs. Further study of the landscape of novel models is recommended.

  15. [Increased expressions of peripheral PD-1+ lymphocytes and CD4+CD25+FOXP3+ T cells in gastric adenocarcinoma patients].

    Science.gov (United States)

    Li, Hao; Li, Songyan; Hu, Shidong; Zou, Guijun; Hu, Zilong; Wei, Huahua; Wang, Yufeng; Du, Xiaohui

    2017-01-01

    Objective To detect the frequencies of peripheral programmed death-1 + (PD-1 + ) lymphocytes and CD4 + CD25 + FOXP3 + regulatory T cells in patients with gastric adenocarcinoma. Methods The study enrolled 29 patients with gastric adenocarcinoma and 29 age- and sex-matched healthy controls. Frequencies of PD-1 + lymphocytes and CD4 + CD25 + FOXP3 + regulatory T cells were detected using flow cytometry. Results The number of PD-1 + lymphocytes and CD4 + CD25 + FOXP3 + regulatory T cells in peripheral blood was higher in patients with gastric adenocarcinoma than that in the control group. Moreover, linear correlation analysis indicated a positive correlation between PD-1 expression and frequency of CD4 + CD25 + FOXP3 + regulatory T cells in peripheral blood of the patients. Conclusion Gastric adenocarcinoma patients present with increased PD-1 + lymphocytes and CD4 + CD25 + FOXP3 + regulatory T cells in the peripheral blood.

  16. CD4+ T cell effects on CD8+ T cell location defined using bioluminescence.

    Directory of Open Access Journals (Sweden)

    Mitra Azadniv

    2011-01-01

    Full Text Available T lymphocytes of the CD8+ class are critical in delivering cytotoxic function and in controlling viral and intracellular infections. These cells are "helped" by T lymphocytes of the CD4+ class, which facilitate their activation, clonal expansion, full differentiation and the persistence of memory. In this study we investigated the impact of CD4+ T cells on the location of CD8+ T cells, using antibody-mediated CD4+ T cell depletion and imaging the antigen-driven redistribution of bioluminescent CD8+ T cells in living mice. We documented that CD4+ T cells influence the biodistribution of CD8+ T cells, favoring their localization to abdominal lymph nodes. Flow cytometric analysis revealed that this was associated with an increase in the expression of specific integrins. The presence of CD4+ T cells at the time of initial CD8+ T cell activation also influences their biodistribution in the memory phase. Based on these results, we propose the model that one of the functions of CD4+ T cell "help" is to program the homing potential of CD8+ T cells.

  17. Organizational aspects of an experimental program for physical education with a strengthened course in professional and applied physical training of future electrical engineers in the railway sector

    Directory of Open Access Journals (Sweden)

    Anzhelika Yefremova

    2017-06-01

    Full Text Available Purpose: to develop an optimized program for physical education with a strengthened course in professional and applied physical training (PAPT for students of railway universities. Material & Methods: analysis and generalization of scientific sources and program-normative documentation on physical education of the higher educational institution of railway transport, survey. Results: the results of the survey of railroad specialists are given. Pilot studies have determined the nature and conditions of professional activity of electrical engineers of railway transport. The experimental program on physical education with the strengthened course of the PAPT of students of railway universities was developed and theoretically justified. Conclusion: structure of the experimental program on physical education with the strengthened course of the PAPT included a theoretical section (8 hours, methodical and practical exercises (6 hours, a practical section (114 hours and a control section (12 hours. The program focuses on improving professionally important physical and psycho-physiological qualities and functions, psychomotor skills and physical performance. The basis of the practical section was the physical exercises from different sections of the current basic curriculum.

  18. Method for improving the use of PASCO brand spectrophotometer using DataStudio program applied to radiometric surveys for LAFTLA

    International Nuclear Information System (INIS)

    Bolanos Rodriguez, Gary

    2008-01-01

    Escuela de Ingenieria Electrica at the Universidad de Costa Rica has developed a procedure for the improved use of a PASCO brand Spectrophotometer of the Laboratorio de Fotonica y Tecnologia Laser Aplicada. The program has used DataStudio for the application in radiometric surveys in LAFTLA. Important conclusions have been obtained by the assembly of optical experiments, software and data collection and analysis, such as the behavior of a emitting source radiation known as black body and its relation to the temperature, wavelength and intensity of light. The user guide has been detailed exposing calibrations of the sensors, the definition of constants needed for obtaining parameters and assembly and commissioning of the equipment. (author) [es

  19. Hype, harmony and human factors: applying user-centered design to achieve sustainable telehealth program adoption and growth.

    Science.gov (United States)

    Rossos, P G; St-Cyr, O; Purdy, B; Toenjes, C; Masino, C; Chmelnitsky, D

    2015-01-01

    Despite decades of international experience with the use of information and communication technologies in healthcare delivery, widespread telehealth adoption remains limited and progress slow. Escalating health system challenges related to access, cost and quality currently coincide with rapid advancement of affordable and reliable internet based communication technologies creating unprecedented opportunities and incentives for telehealth. In this paper, we will describe how Human Factors Engineering (HFE) and user-centric elements have been incorporated into the establishment of telehealth within a large academic medical center to increase acceptance and sustainability. Through examples and lessons learned we wish to increase awareness of HFE and its importance in the successful implementation, innovation and growth of telehealth programs.

  20. Traumatic brain injury rehabilitation, the programs applied in French UEROS units, and the specificity of the Limoges experience.

    Science.gov (United States)

    Hamonet-Torny, J; Fayol, P; Faure, P; Carrière, H; Dumond, J-J

    2013-04-01

    First created in 1996, the French evaluation, retraining, social and vocational orientation units (UEROS) now play a fundamental role in the social and vocational rehabilitation of patients with brain injury. As of today, there exist 30 UEROS centers in France. While their care and treatment objectives are shared, their means of assessment and retraining differ according to the experience of each one. The objective of this article is to describe the specific programs and the different tools put to work in the UEROS of Limoges. The UEROS of Limoges would appear to offer a form of holistic rehabilitation management characterized by the importance of psycho-education and its type of approach towards vocational reintegration. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  1. Applying the system engineering approach to devise a master’s degree program in space technology in developing countries

    Science.gov (United States)

    Jazebizadeh, Hooman; Tabeshian, Maryam; Taheran Vernoosfaderani, Mahsa

    2010-11-01

    Although more than half a century is passed since space technology was first developed, developing countries are just beginning to enter the arena, focusing mainly on educating professionals. Space technology by itself is an interdisciplinary science, is costly, and developing at a fast pace. Moreover, a fruitful education system needs to remain dynamic if the quality of education is the main concern, making it a complicated system. This paper makes use of the System Engineering Approach and the experiences of developed countries in this area while incorporating the needs of the developing countries to devise a comprehensive program in space engineering at the Master's level. The needs of the developing countries as regards space technology education may broadly be put into two categories: to raise their knowledge of space technology which requires hard work and teamwork skills, and to transfer and domesticate space technology while minimizing the costs and maximizing its effectiveness. The requirements of such space education system, which include research facilities, courses, and student projects are then defined using a model drawn from the space education systems in universities in North America and Europe that has been modified to include the above-mentioned needs. Three design concepts have been considered and synthesized through functional analysis. The first one is Modular and Detail Study which helps students specialize in a particular area in space technology. Second is referred to as Integrated and Interdisciplinary Study which focuses on understanding and development of space systems. Finally, the third concept which has been chosen for the purpose of this study, is a combination of the other two, categorizing the required curriculum into seven modules, setting aside space applications. This helps students to not only specialize in one of these modules but also to get hands-on experience in a real space project through participation in summer group

  2. Analysis of combined data from heterogeneous study designs: an applied example from the patient navigation research program.

    Science.gov (United States)

    Roetzheim, Richard G; Freund, Karen M; Corle, Don K; Murray, David M; Snyder, Frederick R; Kronman, Andrea C; Jean-Pierre, Pascal; Raich, Peter C; Holden, Alan Ec; Darnell, Julie S; Warren-Mears, Victoria; Patierno, Steven

    2012-04-01

    The Patient Navigation Research Program (PNRP) is a cooperative effort of nine research projects, with similar clinical criteria but with different study designs. To evaluate projects such as PNRP, it is desirable to perform a pooled analysis to increase power relative to the individual projects. There is no agreed-upon prospective methodology, however, for analyzing combined data arising from different study designs. Expert opinions were thus solicited from the members of the PNRP Design and Analysis Committee. To review possible methodologies for analyzing combined data arising from heterogeneous study designs. The Design and Analysis Committee critically reviewed the pros and cons of five potential methods for analyzing combined PNRP project data. The conclusions were based on simple consensus. The five approaches reviewed included the following: (1) analyzing and reporting each project separately, (2) combining data from all projects and performing an individual-level analysis, (3) pooling data from projects having similar study designs, (4) analyzing pooled data using a prospective meta-analytic technique, and (5) analyzing pooled data utilizing a novel simulated group-randomized design. Methodologies varied in their ability to incorporate data from all PNRP projects, to appropriately account for differing study designs, and to accommodate differing project sample sizes. The conclusions reached were based on expert opinion and not derived from actual analyses performed. The ability to analyze pooled data arising from differing study designs may provide pertinent information to inform programmatic, budgetary, and policy perspectives. Multisite community-based research may not lend itself well to the more stringent explanatory and pragmatic standards of a randomized controlled trial design. Given our growing interest in community-based population research, the challenges inherent in the analysis of heterogeneous study design are likely to become more salient

  3. Data Processing and Programming Applied to an Environmental Radioactivity Laboratory; Desarrollo Informatico Aplicado a un Laboratorio de Radiactividad Ambiental

    Energy Technology Data Exchange (ETDEWEB)

    Trinidad, J.A.; Gasco, C.; Palacios, M.A.

    2009-07-01

    This report is the original research work presented for the attainment of the author master degree and its main objective has been the resolution -by means of friendly programming- of some of the observed problems in the environmental radioactivity laboratory belonging to the Department of Radiological Surveillance and Environmental Radioactivity from CIEMAT. The software has been developed in Visual Basic for applications in Excel files and it solves by macro orders three of the detected problems: a) calculation of characteristic limits for the measurements of the beta total and beta rest activity concentrations according to standards MARLAP, ISO and UNE and the comparison of the three results b) Pb-210 and Po-210 decontamination factor determination in the ultra-low level Am-241 analysis in air samples by alpha spectrometry and c) comparison of two analytical techniques for measuring Pb-210 in air ( direct-by gamma spectrometry- and indirect -by radiochemical separation and alpha spectrometry). The organization processes of the different excel files implied in the subroutines, calculations and required formulae are explained graphically for its comprehension. The advantage of using this kind of programmes is based on their versatility and the ease for obtaining data that lately are required by tables that can be modified as time goes by and the laboratory gets more data with the special applications for describing a method (Pb-210 decontamination factors for americium analysis in air) or comparing temporal series of Pb-210 data analysed by different methods (Pb-210 in air). (Author)

  4. Preliminary results of a program of quality assurance applied to the image service of a public hospital

    International Nuclear Information System (INIS)

    Almeida, Claudio Domingues de; Ferreira, Rubemar de Souza; Marechal, Maria Helena H.; Milano, Nelly Ester

    2001-01-01

    Overall quality in radiological protection and medical image depend largely on keeping certain safety standards and technical procedures in good levels. In this way, in June 1998, the Ministry of Health published the document 453 - Guidelines of Radiological Protection to Medical and Dental Practices, defining different levels of actions and responsibility for radiological installation where the critical starting point was the necessity of a previous quality assurance program (QAP) into the radiological service. Preliminary results of a QAP realized in the Department of Radiology of a high complexity Hospital in Rio de Janeiro has showed that, although the importance of 453 Regulation be recognized, there is a few motivation for implementing it. Besides, during 1999 it was possible to identify film losses of 14,9 % related only to the repetition of exposures in the patients, reflecting in terms of cost about U$ 100,000 a year. Results suggest that losses of 64% of total film are due to under or over exposures and 15% are due to inadequate positioning of either film or patient, evidencing the need for training the technical and medical staff . (author)

  5. Use of interactive multimedia disks in the applied environmental sciences program at the Oregon Institute of Technology

    Science.gov (United States)

    Jones, Charles R.

    Although a number of studies have been performed regarding the use of interactive multimedia disks in education, none were found which investigated their effect on either retention or recruitment for universities. The purpose of this case study was to gather information regarding student and teacher perceptions on the use of interactive multimedia disks and their effect on retention and recruitment. The primary source of data for this case study was student and teacher interviews. A purposive sample of students taking courses using the interactive multimedia disks in course at the Oregon Institute of Technology and at two Oregon high schools was chosen for the case study. Major findings of the case study were as follows: (1) Students interviewed in this case study perceived the interactive multimedia disk-based instructional method to be equally as effective as the lecture method. (2) Time flexibility in class scheduling was slightly more beneficial to female students than male students and the lack of instructor-led classroom interaction was more of a problem for female students than male students. (3) There was no difference in the perceptions of the college students and the high school students regarding the benefits and drawbacks of the interactive multimedia disk-based classes. (4) The flexible class scheduling made possible through the use of interactive multimedia disks influences some Oregon Institute of Technology students to stay and complete their degree programs. (5) There is some potential for interactive multimedia disk-based courses to be a recruiting tool. However, there is no evidence that it has been a successful recruiting tool for the Oregon Institute of Technology yet.

  6. THE CONCEPTUAL MANAGEMENT FRAMEWORK OF MICROCREDIT PROVIDERS FOR ANTI-POVERTY PROGRAMS: A STUDY ON JOINT AND SEVERAL LIABILITY APPLIED IN MITRA MANINDO COOPERATIVE, NORTH SUMATERA, INDONESIA

    Directory of Open Access Journals (Sweden)

    Hartanto A.D.

    2017-07-01

    Full Text Available Microcredit program has been widely adopted by some coutries to enhance low-end enterprieses which is also a part of anti-poverty program. However, the implementation of microcredit distribution has been criticized for its high number of bad credit cases and less-optimacy in decreasing the poverty. Those problems have attracted researchers’ interest to investigate the ideal management model for microcredit program to decrease poverty cases of the members. This case-study shows that Mitra Manindo Copperative in North Sumatera has successfully decreased the poverty faced by the members through the application of the joint and several liability system (JSL. This JSL model successfully enhance the social power shared among the members by grouping method. Institutional dynamicity of the JSL application has also grown trusts among the members which appeared to be the main input to enhance the social cohesion and social capital. Strong social capital has diseminated various values that enhance the productivity of the members’ enterprises. The result of this study can be used as the proliferation in constructing ideal management procedures to apply in microcredit programs by loan providers in order to efficiently and effectively increase members’ earnings.

  7. Applied mathematics

    International Nuclear Information System (INIS)

    Nedelec, J.C.

    1988-01-01

    The 1988 progress report of the Applied Mathematics center (Polytechnic School, France), is presented. The research fields of the Center are the scientific calculus, the probabilities and statistics and the video image synthesis. The research topics developed are: the analysis of numerical methods, the mathematical analysis of the physics and mechanics fundamental models, the numerical solution of complex models related to the industrial problems, the stochastic calculus and the brownian movement, the stochastic partial differential equations, the identification of the adaptive filtering parameters, the discrete element systems, statistics, the stochastic control and the development, the image synthesis techniques for education and research programs. The published papers, the congress communications and the thesis are listed [fr

  8. Regulatory function of cytomegalovirus-specific CD4+CD27-CD28- T cells

    International Nuclear Information System (INIS)

    Tovar-Salazar, Adriana; Patterson-Bartlett, Julie; Jesser, Renee; Weinberg, Adriana

    2010-01-01

    CMV infection is characterized by high of frequencies of CD27 - CD28 - T cells. Here we demonstrate that CMV-specific CD4 + CD27 - CD28 - cells are regulatory T cells (T R ). CD4 + CD27 - CD28 - cells sorted from CMV-stimulated PBMC of CMV-seropositive donors inhibited de novo CMV-specific proliferation of autologous PBMC in a dose-dependent fashion. Compared with the entire CMV-stimulated CD4 + T-cell population, higher proportions of CD4 + CD27 - CD28 - T R expressed FoxP3, TGFβ, granzyme B, perforin, GITR and PD-1, lower proportions expressed CD127 and PD1-L and similar proportions expressed CD25, CTLA4, Fas-L and GITR-L. CMV-CD4 + CD27 - CD28 - T R expanded in response to IL-2, but not to CMV antigenic restimulation. The anti-proliferative effect of CMV-CD4 + CD27 - CD28 - T R significantly decreased after granzyme B or TGFβ inhibition. The CMV-CD4 + CD27 - CD28 - T R of HIV-infected and uninfected donors had similar phenotypes and anti-proliferative potency, but HIV-infected individuals had higher proportions of CMV-CD4 + CD27 - CD28 - T R . The CMV-CD4 + CD27 - CD28 - T R may contribute to the downregulation of CMV-specific and nonspecific immune responses of CMV-infected individuals.

  9. Implementing shared decision making in federally qualified health centers, a quasi-experimental design study: the Office-Guidelines Applied to Practice (Office-GAP) program.

    Science.gov (United States)

    Olomu, Adesuwa; Hart-Davidson, William; Luo, Zhehui; Kelly-Blake, Karen; Holmes-Rovner, Margaret

    2016-08-02

    Use of Shared Decision-Making (SDM) and Decision Aids (DAs) has been encouraged but is not regularly implemented in primary care. The Office-Guidelines Applied to Practice (Office-GAP) intervention is an application of a previous model revised to address guidelines based care for low-income populations with diabetes and coronary heart disease (CHD). To evaluate Office-GAP Program feasibility and preliminary efficacy on medication use, patient satisfaction with physician communication and confidence in decision in low-income population with diabetes and coronary heart disease (CHD) in a Federally Qualified Healthcare Center (FQHC). Ninety-five patients participated in an Office-GAP program. A quasi-experimental design study, over 6 months with 12-month follow-up. Office-GAP program integrates health literacy, communication skills education for patients and physicians, patient/physician decision support tools and SDM into routine care. 1) Implementation rates of planned program elements 2) Patient satisfaction with communication and confidence in decision, and 3) Medication prescription rates. We used the GEE method for hierarchical logistic models, controlling for confounding. Feasibility of the Office-GAP program in the FQHC setting was established. We found significant increase in use of Aspirin/Plavix, statin and beta-blocker during follow-up compared to baseline: Aspirin OR 1.5 (95 % CI: 1.1, 2.2) at 3-months, 1.9 (1.3, 2.9) at 6-months, and 1.8 (1.2, 2.8) at 12-months. Statin OR 1.1 (1.0, 1.3) at 3-months and 1.5 (1.1, 2.2) at 12-months; beta-blocker 1.8 (1.1, 2.9) at 6-months and 12-months. Program elements were consistently used (≥ 98 % clinic attendance at training and tool used). Patient satisfaction with communication and confidence in decision increased. The use of Office-GAP program to teach SDM and use of DAs in real time was demonstrated to be feasible in FQHCs. It has the potential to improve satisfaction with physician communication and

  10. Lineage determination of CD7+ CD5- CD2- and CD7+ CD5+ CD2- lymphoblasts: studies on phenotype, genotype, and gene expression of myeloperoxidase, CD3 epsilon, and CD3 delta.

    Science.gov (United States)

    Yoneda, N; Tatsumi, E; Teshigawara, K; Nagata, S; Nagano, T; Kishimoto, Y; Kimura, T; Yasunaga, K; Yamaguchi, N

    1994-04-01

    The gene expression of myeloperoxidase (MPO), CD3 epsilon, and CD3 delta molecules, the gene rearrangement of T-cell receptor (TCR) delta, gamma, and beta and immunoglobulin heavy (IgH) chain, and the expression of cell-surface antigens were investigated in seven cases of CD7+ CD5- CD2- and four cases of CD7+ CD5+ CD2- acute lymphoblastic leukemia or lymphoblastic lymphoma (ALL/LBL) blasts, which were negative for cytochemical myeloperoxidase (cyMPO). More mature T-lineage blasts were also investigated in a comparative manner. In conclusion, the CD7+ CD5- CD2- blasts included four categories: undifferentiated blasts without lineage commitment, T-lineage blasts, T-/myeloid lineage blasts, and cyMPO-negative myeloblasts. The CD7+ CD5+ CD2- blasts included two categories; T-lineage and T-/myeloid lineage blasts. The 11 cases were of the germ-line gene (G) for TCR beta and IgH. Four cases were G for TCR delta and TCR gamma. The others were of the monoclonally rearranged gene (R) for TCR delta and G for TCR gamma or R for both TCR delta and TCR gamma. The expression or in vitro induction of CD13 and/or CD33 antigens correlated with the immaturity of these neoplastic T cells, since it was observed in all 11 CD7+ CD5- CD2- and CD7+ CD5+ CD2-, and some CD7+ CD5+ CD2+ (CD3- CD4- CD8-) cases, but not in CD3 +/- CD4+ CD8+ or CD3+ CD4+ CD8- cases. CD3 epsilon mRNA, but not CD3 delta mRNA, was detected in two CD7+ CD5- CD2- cases, while mRNA of neither of the two CD3 molecules was detected in the other tested CD7+ CD5- CD2- cases. In contrast, mRNA of both CD3 epsilon and CD3 delta were detected in all CD7+ CD5+ CD2- cases, indicating that CD7+ CD5- CD2- blasts at least belong to T-lineage. The blasts of two CD7+ CD5- CD2- cases with entire germ-line genes and without mRNA of the three molecules (MPO, CD3 epsilon, and CD3 delta) were regarded as being at an undifferentiated stage prior to their commitment to either T- or myeloid-lineage. The co-expression of the genes of MPO

  11. Annual report to DOE of the fusion programs in applied plasma physics and development and technology at GA Technologies Inc., fiscal 1984

    International Nuclear Information System (INIS)

    Ohkawa, T.

    1985-04-01

    The GA programs in Applied Plasma Physics and Development and Technology have registered substantial accomplishments during fiscal 1984. Theoretical work in the MHD area has contributed to further understanding of the physics governing low-q, high-β tokamak discharges, including the effects of a cold plasma mantle and an edge-temperature pedestal. The universal scaling law for the maximum β stable to ideal-MHD modes has been verified for Doublet III and has also been validated for JET, DIII-D, and a Double Dee configuration. Experimental work in Applied Plasma Physics included the development of two new high-energy diagnostics, one for gamma rays and one for tritons (or, in a reactor, alpha particles), both of which can yield essential physics information that is not readily obtainable from the panoply of existing diagnostic instruments. The development of a current-density profile diagnostic continued, and it was found that the instrument could also be used to obtain relative density profiles throughout a tokamak discharge. And tests of an ergodic magnetic limiter scheme indicated that the configuration has the potential to create a stable, radiating boundary layer while reducing the heat load to the walls in future high-power devices. The work carried out in the area of Development and Technology included a group of reactor systems design studies that bring into focus some of the challenges that will be faced by the engineers of fusion power equipment. Closer to realization are advanced rf equipment and superconducting magnet developments, both under design in the area of plasma technologies. Technological developments that apply directly to current experiments as well as to future devices comprise the rest of the GA D and T program

  12. Soluble CD163

    DEFF Research Database (Denmark)

    Møller, Holger J

    2012-01-01

    CD163 is an endocytic receptor for haptoglobin-hemoglobin complexes and is expressed solely on macrophages and monocytes. As a result of ectodomain shedding, the extracellular portion of CD163 circulates in blood as a soluble protein (sCD163) at 0.7-3.9 mg/l in healthy individuals. The function o...

  13. Health status, quality of life, residential stability, substance use, and health care utilization among adults applying to a supportive housing program.

    Science.gov (United States)

    Hwang, Stephen W; Gogosis, Evie; Chambers, Catharine; Dunn, James R; Hoch, Jeffrey S; Aubry, Tim

    2011-12-01

    Supportive housing, defined as subsidized housing in conjunction with site-based social services, may help improve the health and residential stability of highly disadvantaged individuals. This study examined changes in health status, quality of life, substance use, health care utilization, and residential stability among 112 homeless and vulnerably housed individuals who applied to a supportive housing program in Toronto, Canada, from December 2005 to June 2007. Follow-up interviews were conducted every 6 months for 18 months. Comparisons were made between individuals who were accepted into the program (intervention) and those who were wait-listed (usual care) using repeated-measures analyses. Individuals who were accepted into the housing program experienced significantly greater improvements in satisfaction with living situation compared with individuals in the usual care group (time, F(3,3,261) = 47.68, p life measures, health status, health care utilization, or substance use between the two groups over time. Significant improvement in residential stability occurred over time, independent of assigned housing group (time, F(3,3,261) = 9.96, p housing on homeless individuals was limited by the small number of participants who were literally homeless at baseline and by the large number of participants who gained stable housing during the study period regardless of their assigned housing status. Nonetheless, this study shows that highly disadvantaged individuals with a high prevalence of poor physical and mental health and substance use can achieve stable housing.

  14. Evaluation of a sports program in modifying the symptoms of hyperactivity, inattention and impulsiveness applied to children with Attention Deficit Disorder

    Directory of Open Access Journals (Sweden)

    Paula María Jiménez Palomar

    2013-11-01

    Full Text Available The sport is a phenomenon that contributes to physical health, mental balance and social welfare of the user, and promotes a range of habits and values that impact on the further integration of the individual in their environment. People suffering from Attention Deficit Disorder with Hyperactivity, these abilities are impaired and currently studies are needed to support the hypothesis that physical exercise can be an effective adjunct to this problem. This will do a clinical trial to evaluate the effectiveness of a sports program, which seeks to alter the predominant symptoms of Attention Deficit Disorder with Hypeeractivity. The study will be conducted in the Unit of Child and Adolescent Mental Health in Ciudad Real, and participants will be children between 6 and 12 years with this disorder. It shall consist of the comparison of two groups: one that will only receive the normal care given in the unit and another that will be applied also a sports program. The second will be divided into two groups who will implement the program outdoors or indoors, in order to observe any difference between an environment and another. We will assess impulsivity, inattention and hyperactivity using the Conners scale for teachers, school performance, taking into account the quarterly grades and behavior at home with the Conners scale for parents.

  15. Creating Virtual CD-ROM Collections

    Directory of Open Access Journals (Sweden)

    Kam Woods

    2009-10-01

    Full Text Available Over the past 20 years, more than 100,000 CD-ROM titles have been published including thousands of collections of government documents and data. CD-ROMs present preservation challenges at the bit level and in ensuring usability of the preserved artifact. We present techniques we have developed to archive and support user access to a collection of approximately 2,900 CD-ROMs published under the Federal Depository Library Program (FDLP by the United States Government Printing Office (GPO. The project provides web-based access to CD-ROM contents using both migration and emulation and supports remote execution of the raw CD-ROM images. Our project incorporates off-the-shelf, primarily open-source software. The raw data and (METS metadata are made available through AFS, a standard distributed file system, to encourage sharing among libraries.

  16. Single-particle states in ^112Cd probed with the ^111Cd(d,p) reaction

    Science.gov (United States)

    Garrett, P. E.; Jamieson, D.; Demand, G. A.; Finlay, P.; Green, K. L.; Leach, K. G.; Phillips, A. A.; Sumithrarachchi, C. S.; Svensson, C. E.; Triambak, S.; Wong, J.; Ball, G. C.; Hertenberger, R.; Wirth, H.-F.; Kr"Ucken, R.; Faestermann, T.

    2009-10-01

    As part of a program of detailed spectroscopy of the Cd isotopes, the single-particle neutron states in ^112Cd have been probed with the ^111Cd(d,p) reaction. Beams of polarized 22 MeV deuterons, obtained from the LMU/TUM Tandem Accelerator, bombarded a target of ^111Cd. The protons from the reaction, corresponding to excitation energies up to 3 MeV in ^112Cd, were momentum analyzed with the Q3D spectrograph. Cross sections and analyzing powers were fit to results of DWBA calculations, and spectroscopic factors were determined. The results from the experiment, and implications for the structure of ^112Cd, will be presented.

  17. Effectiveness of a CD-ROM Nutrient Analysis Program on Self-Monitoring Behavior of Active Duty Military Personnel Receiving Nutrition Counseling for Weight Loss

    National Research Council Canada - National Science Library

    Heetderks-Cox, Jane

    1999-01-01

    ..., restriction from duty-related travel, and even discharge from military service. Less than 3% of total Air Force active duty population are placed on the punitive Active Duty Mandatory Weight Management Program...

  18. Korelasi Kadar Feritin dengan Jumlah CD4, CD8, dan Rasio CD4/CD8 pada Penyandang Talasemia Mayor Anak

    Directory of Open Access Journals (Sweden)

    Bonnie Arseno

    2017-11-01

    Hasil. Didapatkan jumlah CD4 absolut, CD4%, CD8 absolut dan rasio CD4/CD8 menurun. Selain itu, terdapat jumlah CD4 absolut, CD8 absolut dan CD8% meningkat. Pada kelompok usia ≤5 tahun, korelasi kadar feritin dengan CD8 absolut, CD8%, dan rasio CD4/CD8 berturut-turut menghasilkan koefisien korelasi 0,691, 0,557, -0,680, dan p<0,05. Sementara pada kelompok lama terapi ≤5 tahun korelasi kadar feritin dengan CD8 absolut, CD8%, dan rasio CD4/CD8 menghasilkan koefisien korelasi 0,709, 0,571, -0,726 dengan p<0,05. Kesimpulan. Tidak terdapat korelasi antara kadar feritin dengan jumlah CD4, CD8, rasio CD4/CD8. Peningkatan kadar feritin akan diikuti dengan peningkatan jumlah CD8 absolut dan CD8%, serta penurunan rasio CD4/CD8 pada penyandang talasemia mayor anak berdasar atas usia dan lama terapi ≤5 tahun.

  19. Effect of Educational Program to Encourage Safe Sexual Behaviors Among Addicted Men Refered to Substance Abuse Treatment Centers in Hamadan, Western Iran: Applying the Theory of Planned Behavior

    Directory of Open Access Journals (Sweden)

    Babak Moeini

    2014-06-01

    Full Text Available Introduction: Unsafe sexual behaviors as important risky behaviors can expose individuals and society to dangerous infectious disease such as AIDS and viral hepatitis. Considering the high prevalence of unsafe sexual behaviors, this study aimed to determine the effect of educational programs to encourage safe sexual behaviors among substance abusers referred to substance abuse treatment centers in Hamadan, Western Iran by applying the theory of planned behavior. Materials & Methods: This quasi-experimental study was performed on 104 men substance abusers (52 participants in each of the control and intervention groups referred to substance abuse treatment centers in Hamadan. Data collection tool was a questionnaire containing demographic information and the theory of planned behavior constructs. Before the educational program, questionnaires were completed by both groups. After the pretest in both groups, participants in the intervention group participated in four educational sessions designed based on the theory of planned behavior. Two months after the end of program, posttest was performed. Data was analyzed using independent T-test, chi-square, fisher exact test, McNemar’s test and multiple linear regressions using SPSS-16. Results: After educational intervention, the mean scores of the theory constructs (attitude toward behavior, subjective norms, behavioral control, behavioral intention and behaviors, in the intervention group increased significantly (P<0.05, despite the fact, changes were not significant in the control group. Conclusion: Implementation of educational courses to encourage safe sexual behaviors based on the theory of planned behavior can be beneficial for substance abusers referred to substance abuse treatment centers.

  20. CD4+/CD8+ double-positive T cells

    DEFF Research Database (Denmark)

    Overgaard, Nana H; Jung, Ji-Won; Steptoe, Raymond J

    2015-01-01

    CD4(+)/CD8(+) DP thymocytes are a well-described T cell developmental stage within the thymus. However, once differentiated, the CD4(+) lineage or the CD8(+) lineage is generally considered to be fixed. Nevertheless, mature CD4(+)/CD8(+) DP T cells have been described in the blood and peripheral...... cells, CD4(+)/CD8(+) T cell populations, outside of the thymus, have recently been described to express concurrently ThPOK and Runx3. Considerable heterogeneity exists within the CD4(+)/CD8(+) DP T cell pool, and the function of CD4(+)/CD8(+) T cell populations remains controversial, with conflicting...... reports describing cytotoxic or suppressive roles for these cells. In this review, we describe how transcriptional regulation, lineage of origin, heterogeneity of CD4 and CD8 expression, age, species, and specific disease settings influence the functionality of this rarely studied T cell population....

  1. Applying systematic review search methods to the grey literature: a case study examining guidelines for school-based breakfast programs in Canada.

    Science.gov (United States)

    Godin, Katelyn; Stapleton, Jackie; Kirkpatrick, Sharon I; Hanning, Rhona M; Leatherdale, Scott T

    2015-10-22

    Grey literature is an important source of information for large-scale review syntheses. However, there are many characteristics of grey literature that make it difficult to search systematically. Further, there is no 'gold standard' for rigorous systematic grey literature search methods and few resources on how to conduct this type of search. This paper describes systematic review search methods that were developed and applied to complete a case study systematic review of grey literature that examined guidelines for school-based breakfast programs in Canada. A grey literature search plan was developed to incorporate four different searching strategies: (1) grey literature databases, (2) customized Google search engines, (3) targeted websites, and (4) consultation with contact experts. These complementary strategies were used to minimize the risk of omitting relevant sources. Since abstracts are often unavailable in grey literature documents, items' abstracts, executive summaries, or table of contents (whichever was available) were screened. Screening of publications' full-text followed. Data were extracted on the organization, year published, who they were developed by, intended audience, goal/objectives of document, sources of evidence/resources cited, meals mentioned in the guidelines, and recommendations for program delivery. The search strategies for identifying and screening publications for inclusion in the case study review was found to be manageable, comprehensive, and intuitive when applied in practice. The four search strategies of the grey literature search plan yielded 302 potentially relevant items for screening. Following the screening process, 15 publications that met all eligibility criteria remained and were included in the case study systematic review. The high-level findings of the case study systematic review are briefly described. This article demonstrated a feasible and seemingly robust method for applying systematic search strategies to

  2. Different thresholds of T cell activation regulate FIV infection of CD4+CD25+ and CD4+CD25- cells

    International Nuclear Information System (INIS)

    Joshi, Anjali; Garg, Himanshu; Tompkins, Mary B.; Tompkins, Wayne A.

    2005-01-01

    Cellular activation plays an important role in retroviral replication. Previously, we have shown that CD4 + CD25 + T cells by the virtue of their partially activated phenotype represent ideal candidates for a productive feline immunodeficiency virus (FIV) infection. In the present study, we extended our previous observations with regard to FIV replication in CD4 + CD25 + and CD4 + CD25 - cells under different stimulation conditions. Both CD4 + CD25 + and CD4 + CD25 - cells remain latently infected in the absence of IL-2 or concanvalinA (ConA), respectively; harboring a replication competent provirus capable of reactivation several days post-infection. While CD4 + CD25 + cells require low levels of exogenous IL-2 and virus inputs for an efficient FIV replication, CD4 + CD25 - T cells can only be productively infected in the presence of either high concentrations of IL-2 or high virus titers, even in the absence of mitogenic stimulation. Interestingly, while high virus input activates CD4 + CD25 - cells to replicate FIV, it induces apoptosis in a high percentage of CD4 + CD25 + T cells. High IL-2 concentrations but not high virus inputs lead to surface upregulation of CD25 and significant cellular proliferation in CD4 + CD25 - cells. These results suggest that CD4 + CD25 + and CD4 + CD25 - T cells have different activation requirements which can be modulated by both viral and cytokine stimuli to reach threshold activation levels in order to harbor a productive FIV infection. This holds implications in vivo for CD4 + CD25 + and CD4 + CD25 - cells to serve as potential reservoirs of a productive and latent FIV infection

  3. On the nature of acidic centers in the deep oxidation of olefins over CdMoO/sub 4/: temperature-programmed desorption/Mass spectrometer investigation

    Energy Technology Data Exchange (ETDEWEB)

    Forzatti, P. (Politec. Milano); Kotzev, N.; Gencheva, L.; Pasquon, I.; Shopov, D.; Villa, P.L.

    1980-10-01

    Propylene and 1-butene were adsorbed at room temperature on cadmium molybdate, a poorly selective catalyst for olefin oxidation Temperature-programed desorption occurred at low temperature (145/sup 0/C for propylene, 100/sup 0/C for butene) from a reversibly adsorbed species on A sites, and at high temperature (400/sup 0/C for both olefins) from B sites in dissociated form. The A-sites were apparently vacancies or surface defects, which were destroyed when the cata

  4. CdS/CdSSe quantum dots in glass matrix

    Indian Academy of Sciences (India)

    CdSSe and melted at 1200–1300°C. The glass samples were transparent and pale yellow in colour due to presence of CdS/CdSSe tiny nano crystal (Q-dots). in situ growth of CdS/CdSSe nano crystals imparts the yellow/orange/red colour to ...

  5. THE APPROACH OF THE KINETIC PROGRAM FOR HIPS WITH APPLIED ENDO-PROSTHESIS IN THE “LACU-SARAT BRAILA” RECOVERY CENTER (2006 – 2009.

    Directory of Open Access Journals (Sweden)

    Viorica Lefter

    2010-08-01

    Full Text Available Objectives. The objective of the present study is to relieve the necessity and the efficiency of the kinetic recovery of theoperated hip, and to increase the orthopedist’s trust in the kinetic act as a medical act executed in a responsible and understanding fashion by the qualified staff. Arthroplasty refers to the replacement of a joint deteriorated by a certain pathological process (degenerative arthritis, infection, or tumor with an artificial one, named endoprosthesis, a joint which must remain perfectly functional. The material and the method. The participants were 76 (63% mail patients and 45 (37% female patients, 44 (37% of which with ages between 40 and 60 years, 54 (45% between 60 and 70, and 21 (18% exceeded 70 years of ageInclusion criteria for the study werethe display of the following symptoms: chronic pain, acute pain andmobility reduction. Thus, 52 (42% patients featured acute pain, 42 (33% chronic pain and 35 (27% mobility disorders accompanied by walk disorders, that is, tilting pelvis 67 (55% and limping 54 (45% (Fig. 3, (Fig. 4 with hip prostheses of different types and at various intervals from the intervention. Subjects were clinically, functionally, radiologically and MRI investigated, preoperatively, postoperatively, after 3 months and after 1 year. A recovery program featuring educational, hygienic, diet, medication and physical-kinetic aspects was applied daily for a 14 to 15-day period, followed by kinesiotherapy and massage 2 to 3 times a week, by reevaluation and by a complete treatment at 3 months and at 1 year, respectively. Monitoring was made by the VAS scale for pain, Womac Lequesne for the functional status and Tinetii for the walk. Results. All patients have been evaluated initially, after 10 days and at the completion of the treatment, after 3 months and after 1 year. The recovery of hip arthroplasty must be carried out in time and maintained for the entire life.Conclusions.. Hips with applied endo

  6. Applying the concept of quality of life to Israeli special education programs: a national curriculum for enhanced autonomy in students with special needs.

    Science.gov (United States)

    Reiter, Shunit; Schalock, Robert L

    2008-03-01

    This study provides a description of the design and development of guidelines and programs for a national core curriculum for special education in Israel. Israel was exposed during the 1970s to the ideology of normalization. Later on, toward the end of the 1980s, the concept of quality of life was added. Several research studies were conducted, resulting in the following core ideas about education: a shift of emphasis from teaching independent-living skills to teaching autonomy, self-awareness, self-direction, and interdependence is required. On the basis of these ideas, a new model of instruction was devised and termed the 'cycle of internalized learning' (CIL). The CIL is based on a holistic orientation toward the student and builds on abilities rather than disabilities. The peer group is the basic unit of instruction. Attention is on processes and outcomes. The CIL involves several clearly defined teaching steps: (i) opening--the presentation of the subject matter; (ii) discussion--a conceptual analysis of the subject; (iii) open conversation--students discuss the issues they raised during the first session, express their personal life experiences while applying the new concepts they learned, and suggest possible solutions to problems; (iv) trying out the solutions suggested by students; and (v) repeated discussions, to arrive at personal and social conclusions. Currently there are three published units of the CIL: (i) Social Education, (ii) Career Education, and (iii) Towards Leaving Home for Independent Living in the Community. The fourth unit, on citizenship education through the use of computers, is in its final stages of preparation. The success of the implementation of the program is expressed both at the students' level--as an enhanced sense of self-worth and self-confidence, as well as enhanced academic achievements and social skills--and at the teachers' level--as a paradigm shift from a medical model of approach to students with disabilities to a

  7. Collaborative Approaches to Increase the Utility of Spatial Data for the Wildfire Management Community Through NASA's Applied Remote Sensing Training Program

    Science.gov (United States)

    McCullum, A. J. K.; Schmidt, C.; Blevins, B.; Weber, K.; Schnase, J. L.; Carroll, M.; Prados, A. I.

    2015-12-01

    The utility of spatial data products and tools to assess risk and effectively manage wildfires has increased, highlighting the need for communicating information about these new capabilities to decision makers, resource managers, and community leaders. NASA's Applied Remote Sensing Training (ARSET) program works directly with agencies and policy makers to develop in-person and online training courses that teach end users how to access, visualize, and apply NASA Earth Science data in their profession. The expansion of ARSET into wildfire applications began in 2015 with a webinar and subsequent in-person training hosted in collaboration with Idaho State University's (ISU) GIS Training and Research Center (TReC). These trainings featured presentations from the USDA Forest Service's Remote Sensing Training and Applications Center, the Land Processes DAAC, Northwest Nazarene University, NASA Goddard Space Flight Center, and ISU's GIS TReC. The webinar focused on providing land managers, non-governmental organizations, and international management agencies with an overview of 1) remote sensing platforms for wildfire applications, 2) products for pre- and post-fire planning and assessment, 3) the use of terrain data, 4) new techniques and technologies such as Unmanned Aircraft Systems and the Soil Moisture Active Passive Mission (SMAP), and 5) the RECOVER Decision Support System. This training highlighted online tools that engage the wildfire community through collaborative monitoring and assessment efforts. Webinar attendance included 278 participants from 178 organizations in 42 countries and 33 US states. The majority of respondents (93%) from a post-webinar survey indicated they displayed improvement in their understanding of specific remote-sensing data products appropriate for their work needs. With collaborative efforts between federal, state, and local agencies and academic institutions, increased use of NASA Earth Observations may lead to improved near real

  8. Atmospheric Pressure Chemical Vapor Deposition of CdTe for High-Efficiency Thin-Film PV Devices; Annual Report, 26 January 1998-25 January 1999

    Energy Technology Data Exchange (ETDEWEB)

    Meyers, P. V. [ITN Energy Systems, Wheat Ridge, Colorado (US); Kee, R.; Wolden, C.; Raja, L.; Kaydanov, V.; Ohno, T.; Collins, R.; Aire, M.; Kestner, J. [Colorado School of Mines, Golden, Colorado (US); Fahrenbruch, A. [ALF, Inc., Stanford, California (US)

    1999-09-30

    ITN's 3-year project, titled ''Atmospheric Pressure Chemical Vapor Deposition (APCVD) of CdTe for High-Efficiency Thin-Film Photovoltaic (PV) Devices,'' has the overall objectives of improving thin-film CdTe PV manufacturing technology and increasing CdTe PV device power conversion efficiency. CdTe deposition by APCVD employs the same reaction chemistry as has been used to deposit 16%-efficient CdTe PV films, i.e., close-spaced sublimation, but employs forced convection rather than diffusion as a mechanism of mass transport. Tasks of the APCVD program center on demonstrating APCVD of CdTe films, discovering fundamental mass-transport parameters, applying established engineering principles to the deposition of CdTe films, and verifying reactor design principles that could be used to design high-throughput, high-yield manufacturing equipment. Additional tasks relate to improved device measurement and characterization procedures that can lead to a more fundamental understanding of CdTe PV device operation, and ultimately, to higher device conversion efficiency and greater stability. Specifically, under the APCVD program, device analysis goes beyond conventional one-dimensional device characterization and analysis toward two-dimension measurements and modeling. Accomplishments of the first year of the APCVD subcontract include: selection of the Stagnant Flow Reactor design concept for the APCVD reactor, development of a detailed reactor design, performance of detailed numerical calculations simulating reactor performance, fabrication and installation of an APCVD reactor, performance of dry runs to verify reactor performance, performance of one-dimensional modeling of CdTe PV device performance, and development of a detailed plan for quantification of grain-boundary effects in polycrystalline CdTe devices.

  9. HRM Cd-ROM

    NARCIS (Netherlands)

    drs. C.A.G. Huijsmans; ir. R.B. Opsteeg; drs. H.J.J.L. Seegers

    2006-01-01

    De cd-rom HRM biedt een compleet en actueel overzicht van het totale HRM-gebied. Het bevat een unieke verzameling informatie over personeelsmanagement en sociaal beleid. Deze cd-rom geeft richtlijnen, maatregelen en handige tips op het gebied van personeelsmanagement. Het is samen met het zakboek de

  10. The Status that the program to relieve set-point for the number of operable ICIs is applied to OPR1000

    Energy Technology Data Exchange (ETDEWEB)

    Roh, Kyung-ho; Moon, Sang-rae [KHNP, Daejeon (Korea, Republic of)

    2016-10-15

    The Core Operating Limit Supervisory System (COLSS) of OPR1000 monitors in-core neutron power distribution, Linear Heat Rate (LHR) and Departure from Nucleate Boiling Ratio (DNBR) using In-Core Instrumentation (ICI). It is required that above 75% of ICI be operable to perform this functions. 45 EA strings of ICI have been installed and operated in Hanbit no.3, 4, 5, 6 and Hanul no. 3, 4, 5, 6. Their signals are transferred to Plant Monitoring System (PMS) via four Plant Data Acquisition System (PDAS) channels. PMS includes a few application programs like COLSS. In a case that one of 4 PDAS channels fails, COLSS is inoperable. It means that reactor power should be reduced and monitored by CPCS because FSAR of OPR1000 requires that 75% ICIs should be operable. This action can induce transient of reactor core. In order to complement such a trouble, KHNP, KEPCO NF and KEPCO ENC have proposed the way that COLSS can be operable though operable ICIs exist between 60% - 75%. KHNP, KEPCONF and KEPCO ENC have proposed the way that COLSS can be operable though operable ICIs exist between 60% - 75%. Conservatively, the analysis was performed assuming 50% ICIs are inoperable. Though 50% ICIs are inoperable, the power distribution of COLSS is more accurate than that of CPC. The technology was applied to OPR1000s based on above technical background. Shin-Kori no.1, 2 and Shin-Wolsong no.1, 2 are waiting for an application.

  11. Enhanced Cadmium (Cd Phytoextraction from Contaminated Soil using Cd-Resistant Bacterium

    Directory of Open Access Journals (Sweden)

    Kunchaya Setkit

    2014-01-01

    Full Text Available A cadmium (Cd-resistant bacterium, Micrococcus sp. MU1, is able to produce indole-3-acetic acid and promotes root elongation and plant growth. The potential of this bacterium on enhancement of Cd uptake and bioaccumulation of Cd in Helianthus annuus L. planted in Cd-contaminated soil was evaluated in greenhouse condition. The results showed that Micrococcus sp. MU1promoted the growth of H. annuus L. by increasing the root length, stem height, dry biomass, root to shoot ratio and also significantly increased Cd accumulation in the root and above-ground tissues of H. annuus L. compared to uninoculated control. Re-inoculation with Micrococcus sp. MU1in contaminated soil helped in promoting plant growth and Cd phytoextraction throughout the cultivation period. In addition, phytoextraction coefficient and translocation factor (TF of H. annuus L. inoculated with Micrococcus sp. MU1were higher than that of uninoculated control and TF continuously increased with time. Our results suggested that Micrococcus sp. MU1 has an ability to enhance plant growth and Cd uptake in H. annuus L. Synergistic interaction between Micrococcus sp. MU1 and H. annuus L. could be further applied for Cd phytoextraction in polluted areas.

  12. Applied Electromagnetics

    Energy Technology Data Exchange (ETDEWEB)

    Yamashita, H; Marinova, I; Cingoski, V [eds.

    2002-07-01

    These proceedings contain papers relating to the 3rd Japanese-Bulgarian-Macedonian Joint Seminar on Applied Electromagnetics. Included are the following groups: Numerical Methods I; Electrical and Mechanical System Analysis and Simulations; Inverse Problems and Optimizations; Software Methodology; Numerical Methods II; Applied Electromagnetics.

  13. Applied Electromagnetics

    International Nuclear Information System (INIS)

    Yamashita, H.; Marinova, I.; Cingoski, V.

    2002-01-01

    These proceedings contain papers relating to the 3rd Japanese-Bulgarian-Macedonian Joint Seminar on Applied Electromagnetics. Included are the following groups: Numerical Methods I; Electrical and Mechanical System Analysis and Simulations; Inverse Problems and Optimizations; Software Methodology; Numerical Methods II; Applied Electromagnetics

  14. Characterization of primary cutaneous CD8+/CD30+ lymphoproliferative disorders.

    Science.gov (United States)

    Martires, Kathryn J; Ra, Seong; Abdulla, Farah; Cassarino, David S

    2015-11-01

    CD30 primary cutaneous lymphoproliferative diseases include both lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (PCALCL). The neoplastic cell of most primary CD30 lymphoproliferative disorders is CD4 positive. The terminology LyP "type D" has been used to describe a growing number of cases of LyP with a predominantly CD8 infiltrate. PCALCL with a CD8 phenotype has also been described, which presents a particularly difficult diagnostic and management challenge, given the difficulty in distinguishing it histologically from other cytotoxic lymphomas such as primary cutaneous aggressive epidermotropic CD8 cytotoxic T-cell lymphoma and CD8 gamma/delta and natural killer/T-cell lymphoma. We report 7 additional cases of these rare cutaneous CD8/CD30 lymphoproliferative disorders. We also present a unique case of CD8/CD30 LyP with histologic similarities to LyP type B. In all 7 of our cases of CD8 LyP and CD8 anaplastic large cell lymphoma, we found focal to diffuse MUM-1 positivity. We propose that MUM-1 may represent an adjunctive marker for CD8 lymphoproliferative disease. Finally, we review the current literature on cases of CD8 LyP and PCALCL. For the 106 cases examined, we found similar clinical and histologic features to those reported for traditional CD4CD30 LyP and PCALCL.

  15. Inferring the lithology of borehole rocks by applying neural network classifiers to downhole logs: an example from the Ocean Drilling Program

    Science.gov (United States)

    Benaouda, D.; Wadge, G.; Whitmarsh, R. B.; Rothwell, R. G.; MacLeod, C.

    1999-02-01

    In boreholes with partial or no core recovery, interpretations of lithology in the remainder of the hole are routinely attempted using data from downhole geophysical sensors. We present a practical neural net-based technique that greatly enhances lithological interpretation in holes with partial core recovery by using downhole data to train classifiers to give a global classification scheme for those parts of the borehole for which no core was retrieved. We describe the system and its underlying methods of data exploration, selection and classification, and present a typical example of the system in use. Although the technique is equally applicable to oil industry boreholes, we apply it here to an Ocean Drilling Program (ODP) borehole (Hole 792E, Izu-Bonin forearc, a mixture of volcaniclastic sandstones, conglomerates and claystones). The quantitative benefits of quality-control measures and different subsampling strategies are shown. Direct comparisons between a number of discriminant analysis methods and the use of neural networks with back-propagation of error are presented. The neural networks perform better than the discriminant analysis techniques both in terms of performance rates with test data sets (2-3 per cent better) and in qualitative correlation with non-depth-matched core. We illustrate with the Hole 792E data how vital it is to have a system that permits the number and membership of training classes to be changed as analysis proceeds. The initial classification for Hole 792E evolved from a five-class to a three-class and then to a four-class scheme with resultant classification performance rates for the back-propagation neural network method of 83, 84 and 93 per cent respectively.

  16. Lamont-Doherty's Secondary School Field Research Program: Using Goal-Oriented Applied Research as a Means of Building Comprehensive and Integrated Scientific Understanding

    Science.gov (United States)

    Bostick, B. C.; Newton, R.; Vincent, S.; Peteet, D. M.; Sambrotto, R.; Schlosser, P.; Corbett, E.

    2015-12-01

    Conventional instruction in science often proceeds from the general to the specific and from text to action. Fundamental terminologies, concepts, and ideas that are often abstract are taught first and only after such introductory processes can a student engage in research. Many students struggle to find relevance when presented information without context specific to their own experiences. This challenge is exacerbated for students whose social circles do not include adults who can validate scientific learning from their own experiences. Lamont-Doherty's Secondary School Field Research Program inverts the standard paradigm and places small groups of students in research projects where they begin by performing manageable tasks on complex applied research projects. These tasks are supplemented with informal mentoring and relevant articles (~1 per week). Quantitative metrics suggest the approach is highly successful—most participants report a dramatic increase in their enthusiasm for science, 100% attend college, and approximately 50% declare majors in science or technology. We use one project, the construction of a microbial battery, to illustrate this novel model of science learning and argue that it should be considered a best practice for project-based science education. The goal of this project was to build a rechargeable battery for a mobile phone based on a geochemical cycle, to generate and store electricity. The students, mostly from ethnic groups under-represented in the STEM fields, combined concepts and laboratory methods from biology, chemistry and physics to isolate photosynthetic bacteria from a natural salt marsh, and made an in situ device capable of powering a light bulb. The younger participants had been exposed to neither high school chemistry nor physics at the start of the project, yet they were able to use the project as a platform to deepen their science knowledge and their desire for increased participation in formal science education.

  17. Alberta Stroke Program Early CT Score applied to CT angiography source images is a strong predictor of futile recanalization in acute ischemic stroke

    Energy Technology Data Exchange (ETDEWEB)

    Kawiorski, Michal M.; Alonso de Lecinana, Maria [Hospital Universitario La Paz, IdiPAZ, Universidad Autonoma de Madrid, Madrid (Spain); Hospital Universitario Ramon y Cajal, IRYCIS, Universidad de Alcala de Henares, Madrid (Spain); Martinez-Sanchez, Patricia; Fuentes, Blanca; Sanz-Cuesta, Borja E.; Marin, Begona; Ruiz-Ares, Gerardo; Diez-Tejedor, Exuperio [Hospital Universitario La Paz, IdiPAZ, Universidad Autonoma de Madrid, Madrid (Spain); Garcia-Pastor, Andres; Diaz-Otero, Fernando [Hospital Universitario Gregorio Maranon, IiSGM, Universidad Complutense de Madrid, Madrid (Spain); Calleja, Patricia [Hospital Universitario 12 de Octubre, Universidad Autonoma de Madrid, Madrid (Spain); Lourido, Daniel; Vicente, Agustina; Fandino, Eduardo [Hospital Universitario Ramon y Cajal, IRYCIS, Universidad de Alcala de Henares, Madrid (Spain); Sierra-Hidalgo, Fernando [Hospital Universitario 12 de Octubre, Universidad Autonoma de Madrid, Madrid (Spain); Hospital Universitario Infanta Leonor, Universidad Complutense de Madrid, Madrid (Spain)

    2016-05-15

    Reliable predictors of poor clinical outcome despite successful revascularization might help select patients with acute ischemic stroke for thrombectomy. We sought to determine whether baseline Alberta Stroke Program Early CT Score (ASPECTS) applied to CT angiography source images (CTA-SI) is useful in predicting futile recanalization. Data are from the FUN-TPA study registry (ClinicalTrials.gov; NCT02164357) including patients with acute ischemic stroke due to proximal arterial occlusion in anterior circulation, undergoing reperfusion therapies. Baseline non-contrast CT and CTA-SI-ASPECTS, time-lapse to image acquisition, occurrence, and timing of recanalization were recorded. Outcome measures were NIHSS at 24 h, symptomatic intracranial hemorrhage, modified Rankin scale score, and mortality at 90 days. Futile recanalization was defined when successful recanalization was associated with poor functional outcome (death or disability). Included were 110 patients, baseline NIHSS 17 (IQR 12; 20), treated with intravenous thrombolysis (IVT; 45 %), primary mechanical thrombectomy (MT; 16 %), or combined IVT + MT (39 %). Recanalization rate was 71 %, median delay of 287 min (225; 357). Recanalization was futile in 28 % of cases. In an adjusted model, baseline CTA-SI-ASPECTS was inversely related to the odds of futile recanalization (OR 0.5; 95 % CI 0.3-0.7), whereas NCCT-ASPECTS was not (OR 0.8; 95 % CI 0.5-1.2). A score ≤5 in CTA-SI-ASPECTS was the best cut-off to predict futile recanalization (sensitivity 35 %; specificity 97 %; positive predictive value 86 %; negative predictive value 77 %). CTA-SI-ASPECTS strongly predicts futile recanalization and could be a valuable tool for treatment decisions regarding the indication of revascularization therapies. (orig.)

  18. Alberta Stroke Program Early CT Score applied to CT angiography source images is a strong predictor of futile recanalization in acute ischemic stroke

    International Nuclear Information System (INIS)

    Kawiorski, Michal M.; Alonso de Lecinana, Maria; Martinez-Sanchez, Patricia; Fuentes, Blanca; Sanz-Cuesta, Borja E.; Marin, Begona; Ruiz-Ares, Gerardo; Diez-Tejedor, Exuperio; Garcia-Pastor, Andres; Diaz-Otero, Fernando; Calleja, Patricia; Lourido, Daniel; Vicente, Agustina; Fandino, Eduardo; Sierra-Hidalgo, Fernando

    2016-01-01

    Reliable predictors of poor clinical outcome despite successful revascularization might help select patients with acute ischemic stroke for thrombectomy. We sought to determine whether baseline Alberta Stroke Program Early CT Score (ASPECTS) applied to CT angiography source images (CTA-SI) is useful in predicting futile recanalization. Data are from the FUN-TPA study registry (ClinicalTrials.gov; NCT02164357) including patients with acute ischemic stroke due to proximal arterial occlusion in anterior circulation, undergoing reperfusion therapies. Baseline non-contrast CT and CTA-SI-ASPECTS, time-lapse to image acquisition, occurrence, and timing of recanalization were recorded. Outcome measures were NIHSS at 24 h, symptomatic intracranial hemorrhage, modified Rankin scale score, and mortality at 90 days. Futile recanalization was defined when successful recanalization was associated with poor functional outcome (death or disability). Included were 110 patients, baseline NIHSS 17 (IQR 12; 20), treated with intravenous thrombolysis (IVT; 45 %), primary mechanical thrombectomy (MT; 16 %), or combined IVT + MT (39 %). Recanalization rate was 71 %, median delay of 287 min (225; 357). Recanalization was futile in 28 % of cases. In an adjusted model, baseline CTA-SI-ASPECTS was inversely related to the odds of futile recanalization (OR 0.5; 95 % CI 0.3-0.7), whereas NCCT-ASPECTS was not (OR 0.8; 95 % CI 0.5-1.2). A score ≤5 in CTA-SI-ASPECTS was the best cut-off to predict futile recanalization (sensitivity 35 %; specificity 97 %; positive predictive value 86 %; negative predictive value 77 %). CTA-SI-ASPECTS strongly predicts futile recanalization and could be a valuable tool for treatment decisions regarding the indication of revascularization therapies. (orig.)

  19. In Preparation of the Nationwide Dissemination of the School-Based Obesity Prevention Program DOiT: Stepwise Development Applying the Intervention Mapping Protocol

    NARCIS (Netherlands)

    van Nassau, F.; Singh, A.S.; van Mechelen, W.; Brug, J.; Chin A Paw, M.J.M.

    2014-01-01

    BACKGROUND: The school-based Dutch Obesity Intervention in Teenagers (DOiT) program is an evidence-based obesity prevention program. In preparation for dissemination throughout the Netherlands, this study aimed to adapt the initial program and to develop an implementation strategy and materials.

  20. In Preparation of the Nationwide Dissemination of the School-Based Obesity Prevention Program DOiT: Stepwise Development Applying the Intervention Mapping Protocol

    Science.gov (United States)

    van Nassau, Femke; Singh, Amika S.; van Mechelen, Willem; Brug, Johannes; Chin A. Paw, Mai J. M.

    2014-01-01

    Background: The school-based Dutch Obesity Intervention in Teenagers (DOiT) program is an evidence-based obesity prevention program. In preparation for dissemination throughout the Netherlands, this study aimed to adapt the initial program and to develop an implementation strategy and materials. Methods: We revisited the Intervention Mapping (IM)…

  1. Documentation of a Regional Aquifer Simulation Model RAQSIM, and a description of support programs applied in the Twin Platte - Middle Republican Study Area, Nebraska

    Science.gov (United States)

    Cady, R.E.; Peckenpaugh, J.M.

    1985-01-01

    RAQSIM, a generalized flow model of a groundwater system using finite-element methods, is documented to explain how it works and to demonstrate that it gives valid results. Three support programs that are used to compute recharge and discharge data required as input to RAQSIM are described. RAQSIM was developed to solve transient, two-dimensional, regional groundwater flow problems with isotropic or anisotropic conductance. The model can also simulate radially-symmetric flow to a well and steady-state flow. The mathematical basis, program structure, data input and output procedures, organization of data sets, and program features and options of RAQSIM are discussed. An example , containing listings of data and results and illustrating RAQSIM 's capabilities, is discussed in detail. Two test problems also are discussed comparing RAQSIM 's results with analytical procedures. The first support program described, the PET Program, uses solar radiation and other climatic data in the Jensen-Haise method to compute potential evapotranspiration. The second support program, the Soil-Water Program, uses output from the PET Program, soil characteristics, and the ratio of potential to actual evapotranspiration for each crop to compute infiltration, storage, and removal of water from the soil zone. The third program, the Recharge-Discharge Program, uses output from the Soil-Water Program together with other data to compute recharge and discharge from the groundwater flow system. For each support program, a program listing and examples of the data and results for the Twin Platte-Middle Republican study are provided. In addition, a brief discussion on how each program operates and on procedures for running and modifying these programs are presented. (Author 's abstract)

  2. Molecular pathways of early CD105-positive erythroid cells as compared with CD34-positive common precursor cells by flow cytometric cell-sorting and gene expression profiling

    International Nuclear Information System (INIS)

    Machherndl-Spandl, S; Suessner, S; Danzer, M; Proell, J; Gabriel, C; Lauf, J; Sylie, R; Klein, H-U; Béné, M C; Weltermann, A; Bettelheim, P

    2013-01-01

    Special attention has recently been drawn to the molecular network of different genes that are responsible for the development of erythroid cells. The aim of the present study was to establish in detail the immunophenotype of early erythroid cells and to compare the gene expression profile of freshly isolated early erythroid precursors with that of the CD34-positive (CD34 + ) compartment. Multiparameter flow cytometric analyses of human bone marrow mononuclear cell fractions (n=20) defined three distinct early erythroid stages. The gene expression profile of sorted early erythroid cells was analyzed by Affymetrix array technology. For 4524 genes, a differential regulation was found in CD105-positive erythroid cells as compared with the CD34 + progenitor compartment (2362 upregulated genes). A highly significant difference was observed in the expression level of genes involved in transcription, heme synthesis, iron and mitochondrial metabolism and transforming growth factor-β signaling. A comparison with recently published data showed over 1000 genes that as yet have not been reported to be upregulated in the early erythroid lineage. The gene expression level within distinct pathways could be illustrated directly by applying the Ingenuity software program. The results of gene expression analyses can be seen at the Gene Expression Omnibus repository

  3. Applied superconductivity

    CERN Document Server

    Newhouse, Vernon L

    1975-01-01

    Applied Superconductivity, Volume II, is part of a two-volume series on applied superconductivity. The first volume dealt with electronic applications and radiation detection, and contains a chapter on liquid helium refrigeration. The present volume discusses magnets, electromechanical applications, accelerators, and microwave and rf devices. The book opens with a chapter on high-field superconducting magnets, covering applications and magnet design. Subsequent chapters discuss superconductive machinery such as superconductive bearings and motors; rf superconducting devices; and future prospec

  4. CD3+CD8+CD161high Tc17 cells are depleted in HIV-infection

    DEFF Research Database (Denmark)

    Gaardbo, Julie Christine; Hartling, Hans Jakob; Thorsteinsson, Kristina

    2012-01-01

    CD8+ Tc17 cells with pro-inflammatory properties have only recently been acknowledged, and Tc17 cells in HIV-infection are undescribed. CD3+CD8+CD161 Tc17 cells and the production of Interleukin-17 were examined in untreated and treated HIV-infected patients, HIV-HCV co-infected patients...... and healthy controls. Depletion of CD3+CD8+CD161 Tc17 cells and diminished production of Interleukin-17 in HIV-infected patients was found. The level of Tc17 cells was associated with the level of the CD4+ count in treated patients....

  5. Electrokinetic remediation on cadmium (CD) spiked soils

    Energy Technology Data Exchange (ETDEWEB)

    Sah Jy-Gau [Dept. of Environmental Science and Engineering, National Pingtung Univ. of Science and Technology, Pingtung (Taiwan); Yu Lin, L. [Dept. of Civil and Environmental Engineering, Christian Bros. Univ. Memphis, TN (United States)

    2001-07-01

    The objective of this study is to examine several variables, such as soil pH, adsorption capacity, fraction of Cd in soils, and organic content for Cd removal in contaminated soil using electrokinetic technology. Two different experimental modules were constructed in the laboratory. In the small module, most Cd was able to move and concentrate at or near the cathode zone in acidic soil and neutral soil under 8 volts after 30 days of electrification. However, the Cd removal efficiency did not improve even when the alkaline soil was soaked in stronger acid solutions. The results indicated that the removal efficiencies were influenced not only by the pH of conducting solutions, but also the pH of the soils. The removal efficiencies of Cd were reduced when a portion of organic peat moss was added into the soils. The increases of organic content in the soils inhibit the removal efficiency in electrokinetic technology. In the larger scale module, the removal efficiency of Cd was lower than that in the smaller module during a short period of time. Nevertheless, the efficiency was improved in the larger module while 16 volts electric pressure and 180 days were applied to the module. The results also showed that the sequence of removal efficiency of the three soils in larger module followed the changes of soil pH. From this study, it concluded that electrokinetic technology has a highly potential to removal Cd in contaminated soils. Within these influence variable studies, the soil pH and organic content are the most important factor in electrokinetic technology. Keywords: Electrokinetic Technique, Heavy Metal, Cd, Soil Remediation. (orig.)

  6. Programming

    International Nuclear Information System (INIS)

    Jackson, M.A.

    1982-01-01

    The programmer's task is often taken to be the construction of algorithms, expressed in hierarchical structures of procedures: this view underlies the majority of traditional programming languages, such as Fortran. A different view is appropriate to a wide class of problem, perhaps including some problems in High Energy Physics. The programmer's task is regarded as having three main stages: first, an explicit model is constructed of the reality with which the program is concerned; second, this model is elaborated to produce the required program outputs; third, the resulting program is transformed to run efficiently in the execution environment. The first two stages deal in network structures of sequential processes; only the third is concerned with procedure hierarchies. (orig.)

  7. Programming

    OpenAIRE

    Jackson, M A

    1982-01-01

    The programmer's task is often taken to be the construction of algorithms, expressed in hierarchical structures of procedures: this view underlies the majority of traditional programming languages, such as Fortran. A different view is appropriate to a wide class of problem, perhaps including some problems in High Energy Physics. The programmer's task is regarded as having three main stages: first, an explicit model is constructed of the reality with which the program is concerned; second, thi...

  8. Synthesis and characterization of a surface-grafted Cd(II) ion-imprinted polymer for selective separation of Cd(II) ion from aqueous solution

    Energy Technology Data Exchange (ETDEWEB)

    Li, Min [State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing 100081 (China); Feng, Changgen, E-mail: cgfeng@cast.org.cn [State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing 100081 (China); Li, Mingyu; Zeng, Qingxuan; Gan, Qiang [State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing 100081 (China); Yang, Haiyan [Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057 (China)

    2015-03-30

    Highlights: • Cd(II) ion-imprinted polymer (Cd(II)-IIP) is prepared. • Cd(II)-IIP shows high stability, good selectivity and reusability. • Cd(II)-IIP can be used as a sorbent for selective removal of Cd(II) ion. - Abstract: A novel Cd(II) ion-imprinted polymer (Cd(II)-IIP) was prepared with surface imprinting technology by using cadmium chloride as a template and allyl thiourea (ATU) as a functional monomer for on-line solid-phase extraction of trace Cd(II) ion and selective separation Cd(II) ion in water samples. The Cd(II)-IIP exhibited good chemical performance and thermal stability. Kinetics studies showed that the equilibrium adsorption was achieved within 8.0 min and the adsorption process can be described by pseudo-second-order kinetic model. Compared to the Cd(II) non-imprinted polymer (Cd(II)-NIP), the Cd(II)-IIP had a higher adsorption capacity and selectivity for Cd(II) ion. The maximum adsorption capacities of the Cd(II)-IIP and Cd(II)-NIP for Cd(II) were 38.30 and 13.21 mg g{sup −1}, respectively. The relative selectivity coefficients of the adsorbent for Cd(II) in the presence of Cu{sup 2+}, Ni{sup 2+}, Co{sup 2+}, Pb{sup 2+} and Zn{sup 2+} were 2.86, 6.42, 11.50, 9.46 and 3.73, respectively. In addition, the Cd(II) ion adsorbed was easy to remove from sorbent and the Cd(II)-IIP exhibited good stability and reusability. The adsorption capacity had no obvious decrease after being used six times. The accuracy of this method was verified by the standard reference material, it was then applied for cadmium ion determination in different types of water samples.

  9. Applied mathematics

    CERN Document Server

    Logan, J David

    2013-01-01

    Praise for the Third Edition"Future mathematicians, scientists, and engineers should find the book to be an excellent introductory text for coursework or self-study as well as worth its shelf space for reference." -MAA Reviews Applied Mathematics, Fourth Edition is a thoroughly updated and revised edition on the applications of modeling and analyzing natural, social, and technological processes. The book covers a wide range of key topics in mathematical methods and modeling and highlights the connections between mathematics and the applied and nat

  10. Transcriptome Analysis of Mycobacteria-Specific CD4+ T Cells Identified by Activation-Induced Expression of CD154.

    Science.gov (United States)

    Kunnath-Velayudhan, Shajo; Goldberg, Michael F; Saini, Neeraj K; Johndrow, Christopher T; Ng, Tony W; Johnson, Alison J; Xu, Jiayong; Chan, John; Jacobs, William R; Porcelli, Steven A

    2017-10-01

    Analysis of Ag-specific CD4 + T cells in mycobacterial infections at the transcriptome level is informative but technically challenging. Although several methods exist for identifying Ag-specific T cells, including intracellular cytokine staining, cell surface cytokine-capture assays, and staining with peptide:MHC class II multimers, all of these have significant technical constraints that limit their usefulness. Measurement of activation-induced expression of CD154 has been reported to detect live Ag-specific CD4 + T cells, but this approach remains underexplored and, to our knowledge, has not previously been applied in mycobacteria-infected animals. In this article, we show that CD154 expression identifies adoptively transferred or endogenous Ag-specific CD4 + T cells induced by Mycobacterium bovis bacillus Calmette-Guérin vaccination. We confirmed that Ag-specific cytokine production was positively correlated with CD154 expression by CD4 + T cells from bacillus Calmette-Guérin-vaccinated mice and show that high-quality microarrays can be performed from RNA isolated from CD154 + cells purified by cell sorting. Analysis of microarray data demonstrated that the transcriptome of CD4 + CD154 + cells was distinct from that of CD154 - cells and showed major enrichment of transcripts encoding multiple cytokines and pathways of cellular activation. One notable finding was the identification of a previously unrecognized subset of mycobacteria-specific CD4 + T cells that is characterized by the production of IL-3. Our results support the use of CD154 expression as a practical and reliable method to isolate live Ag-specific CD4 + T cells for transcriptomic analysis and potentially for a range of other studies in infected or previously immunized hosts. Copyright © 2017 by The American Association of Immunologists, Inc.

  11. Applied Enzymology.

    Science.gov (United States)

    Manoharan, Asha; Dreisbach, Joseph H.

    1988-01-01

    Describes some examples of chemical and industrial applications of enzymes. Includes a background, a discussion of structure and reactivity, enzymes as therapeutic agents, enzyme replacement, enzymes used in diagnosis, industrial applications of enzymes, and immobilizing enzymes. Concludes that applied enzymology is an important factor in…

  12. Differential expression of the costimulatory molecules CD86, CD28, CD152 and PD-1 correlates with the host-parasite outcome in leprosy

    Directory of Open Access Journals (Sweden)

    Maria de Lourdes Palermo

    2012-12-01

    Full Text Available Leprosy is a spectral disease exhibiting two polar sides, namely, lepromatous leprosy (LL characterised by impaired T-cell responses and tuberculoid leprosy in which T-cell responses are strong. Proper T-cell activation requires signalling through costimulatory molecules expressed by antigen presenting cells and their ligands on T-cells. We studied the influence of costimulatory molecules on the immune responses of subjects along the leprosy spectrum. The expression of the costimulatory molecules was evaluated in in vitro-stimulated peripheral blood mononuclear cells of lepromatous and tuberculoid patients and healthy exposed individuals (contacts. We show that LL patients have defective monocyte CD86 expression, which likely contributes to the impairment of the antigen presentation process and to patients anergy. Accordingly, CD86 but not CD80 blockade inhibited the lymphoproliferative response to Mycobacterium leprae. Consistent with the LL anergy, there was reduced expression of the positive signalling costimulatory molecules CD28 and CD86 on the T-cells in these patients. In contrast, tuberculoid leprosy patients displayed increased expression of the negative signalling molecules CD152 and programmed death-1 (PD-1, which represents a probable means of modulating an exacerbated immune response and avoiding immunopathology. Notably, the contacts exhibited proper CD86 and CD28 expression but not exacerbated CD152 or PD-1 expression, suggesting that they tend to develop a balanced immunity without requiring immunosuppressive costimulatory signalling.

  13. Randomized Trial of an eLearning Program for Training Family Members of Children with Autism in the Principles and Procedures of Applied Behavior Analysis

    Science.gov (United States)

    Jang, Jina; Dixon, Dennis R.; Tarbox, Jonathan; Granpeesheh, Doreen; Kornack, Julie; de Nocker, Yanicka

    2012-01-01

    Effective training of caregivers is an integral part of top-quality treatment programs for individuals with autism spectrum disorders (ASD). However, traditional caregiver training can be time consuming and costly. The development of Web-based electronic training programs (e.g., "eLearning") may extend training to rural areas, thereby…

  14. Evaluation of liquid metal embrittlement of SS304 by Cd and Cd-Al solutions

    International Nuclear Information System (INIS)

    Thomas, J.K.; Iyer, N.C.; Begley, J.A.

    1992-01-01

    The susceptibility of stainless steel 304 to liquid metal embrittlement (LME) by cadmium (Cd) and cadmium-aluminum (Cd-Al) solutions was examined as part of a failure evaluation for SS304-clad cadmium reactor safety rods which had been exposed to elevated temperatures. The active, or cadmium (Cd) bearing, portion of the safety rod consists of a 0.756 in. diameter aluminum allow (Al-6061) core, a 0.05 in. thick Cd layer, and a 0.042 in. thick Type 304 stainless steel cladding. The safety rod thermal tests were conducted as part of a program to define the response of reactor core components to a hypothetical LOCA for the Savannah River Site (SRS) production reactor. LME was considered as a potential failure mechanism based on the nature of the failure and susceptibility of austenitic stainless steels to embrittlement by other liquid metals

  15. Applied research in the ININ, solutions to challenges traced by the National Development Program; Investigacion aplicada en el ININ, soluciones a retos planteados por el programa Nacional de Desarrollo

    Energy Technology Data Exchange (ETDEWEB)

    Balcazar, M

    1991-05-15

    The National Program of Development 1991-1994 and the necessities expressed by the society as regards Energy, Ecology, Feeding, Industry and Health, they outline problems of inevitable solution. This articulates it presents the contribution to the solution of some of these problems that the investigators associated to the Management of Applied Investigation of the Inn provide by means of specific projects. (Author)

  16. Reassignment of oxygen-related defects in CdTe and CdSe

    Energy Technology Data Exchange (ETDEWEB)

    Bastin, Dirk

    2015-05-22

    This thesis reassigns the O{sub Te}-V{sub Cd} complex in CdTe and the O{sub Se}-V{sub Cd} complex in CdSe to a sulfur-dioxygen complex SO{sub 2}*, and the O{sub Cd} defect in CdSe to a V{sub Cd}H{sub 2} complex using Fourier transformed infrared absorption spectroscopy. The publications of the previous complexes were investigated by theoreticians who performed first-principle calculations of theses complexes. The theoreticians ruled out the assignments and proposed alternative defects, instead. The discrepancy between the experimentally obtained and theoretically proposed defects was the motivation of this work. Two local vibrational modes located at 1096.8 (ν{sub 1}) and 1108.3 cm{sup -1} (ν{sub 2}) previously assigned to an O{sub Te}-V{sub Cd} complex are detected in CdTe single crystals doped with CdSO{sub 4} powder. Five weaker additional absorption lines accompanying ν{sub 1} and ν{sub 2} could be detected. The relative intensities of the absorption lines match a sulfur-dioxygen complex SO{sub 2}* having two configurations labeled ν{sub 1} and ν{sub 2}. A binding energy difference of 0.5±0.1 meV between the two configurations and an energy barrier of 53±4 meV separating the two configurations are determined. Uniaxial stress applied to the crystal leads to a splitting of the absorption lines which corresponds to an orthorhombic and monoclinic symmetry for ν{sub 1} and ν{sub 2}, respectively. In virgin and oxygen-doped CdSe single crystals, three local vibrational modes located at 1094.1 (γ{sub 1}), 1107.5 (γ{sub 2}), and 1126.3 cm{sup -1} (γ{sub 3}) previously attributed to an O{sub Se}-V{sub Cd} complex could be observed. The signals are accompanied by five weaker additional absorption features in their vicinity. The additional absorption lines are identified as isotope satellites of a sulfur-dioxygen complex SO{sub 2}* having three configurations γ{sub 1}, γ{sub 2}, and γ{sub 3}. IR absorption measurements with uniaxial stress applied to the

  17. The large-area CdTe thin film for CdS/CdTe solar cell prepared by physical vapor deposition in medium pressure

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Run; Liu, Bo; Yang, Xiaoyan; Bao, Zheng; Li, Bing, E-mail: libing70@126.com; Zhang, Jingquan; Li, Wei; Wu, Lili; Feng, Lianghuan

    2016-01-01

    Graphical abstract: - Highlights: • The large-area CdTe film has been prepared by PVD under the pressure of 0.9 kPa. • The as-prepared CdTe thin film processes excellent photovoltaic properties. • This technique is suitable for depositing large-area CdTe thin film. • The 14.6% champion efficiency CdS/CdTe cell has been achieved. - Abstract: The Cadmium telluride (CdTe) thin film has been prepared by physical vapor deposition (PVD), the Ar + O{sub 2} pressure is about 0.9 kPa. This method is a newer technique to deposit CdTe thin film in large area, and the size of the film is 30 × 40 cm{sup 2}. This method is much different from the close-spaced sublimation (CSS), as the relevance between the source temperature and the substrate temperature is weak, and the gas phase of CdTe is transferred to the substrate by Ar + O{sub 2} flow. Through this method, the compact and uniform CdTe film (30 × 40 cm{sup 2}) has been achieved, and the performances of the CdTe thin film have been determined by transmission spectrum, SEM and XRD. The film is observed to be compact with a good crystallinity, the CdTe is polycrystalline with a cubic structure and a strongly preferred (1 1 1) orientation. Using the CdTe thin film (3 × 5 cm{sup 2}) which is taken from the deposited large-area film, the 14.6% efficiency CdS/CdTe thin film solar cell has been prepared successfully. The structure of the cell is glass/FTO/CdS/CdTe/graphite slurry/Au, short circuit current density (J{sub sc}) of the cell is 26.9 mA/cm{sup 2}, open circuit voltage (V{sub oc}) is 823 mV, and filling factor (FF) is 66.05%. This technique can be a quite promising method to apply in the industrial production, as it has great prospects in the fabricating of large-area CdTe film.

  18. CD-RW/DVD-ROM drive SD-R1002; CD-RW/DVD-ROM drive SD-R1002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    With the availability of DVD programs increasing at a rapid rate, it has become a general practice to equip a personal computer with a DVD-ROM drive. Toshiba, with a view to meeting the sharp increase in the demand for CD-R/RW (Recordable/ReWritable) recording these days, has commercialized a CD-R/RW drive capable of DVD-ROM reproduction and thereby newly entered into the CD-R/RW drive market. The new product is characterized by (1) the height halved to 41.5mm, (2) quad-speed CD-R/RW recording, (3) 24-speed CD-ROM playback at the maximum, (4) 4.8-speed DVD-ROM playback at the maximum, (5) ATAPI (AT Packet Interface) interface, and (6) access at high speeds, 160ms for DVD and 110ms for CD. (translated by NEDO)

  19. Applied dynamics

    CERN Document Server

    Schiehlen, Werner

    2014-01-01

    Applied Dynamics is an important branch of engineering mechanics widely applied to mechanical and automotive engineering, aerospace and biomechanics as well as control engineering and mechatronics. The computational methods presented are based on common fundamentals. For this purpose analytical mechanics turns out to be very useful where D’Alembert’s principle in the Lagrangian formulation proves to be most efficient. The method of multibody systems, finite element systems and continuous systems are treated consistently. Thus, students get a much better understanding of dynamical phenomena, and engineers in design and development departments using computer codes may check the results more easily by choosing models of different complexity for vibration and stress analysis.

  20. Innate signals overcome acquired TCR signaling pathway regulation and govern the fate of human CD161(hi) CD8α⁺ semi-invariant T cells.

    Science.gov (United States)

    Turtle, Cameron J; Delrow, Jeff; Joslyn, Rochelle C; Swanson, Hillary M; Basom, Ryan; Tabellini, Laura; Delaney, Colleen; Heimfeld, Shelly; Hansen, John A; Riddell, Stanley R

    2011-09-08

    Type 17 programmed CD161(hi)CD8α(+) T cells contribute to mucosal immunity to bacteria and yeast. In early life, microbial colonization induces proliferation of CD161(hi) cells that is dependent on their expression of a semi-invariant Vα7.2(+) TCR. Although prevalent in adults, CD161(hi)CD8α(+) cells exhibit weak proliferative and cytokine responses to TCR ligation. The mechanisms responsible for the dichotomous response of neonatal and adult CD161(hi) cells, and the signals that enable their effector function, have not been established. We describe acquired regulation of TCR signaling in adult memory CD161(hi)CD8α(+) T cells that is absent in cord CD161(hi) cells and adult CD161(lo) cells. Regulated TCR signaling in CD161(hi) cells was due to profound alterations in TCR signaling pathway gene expression and could be overcome by costimulation through CD28 or innate cytokine receptors, which dictated the fate of their progeny. Costimulation with IL-1β during TCR ligation markedly increased proinflammatory IL-17 production, while IL-12-induced Tc1-like function and restored the response to TCR ligation without costimulation. CD161(hi) cells from umbilical cord blood and granulocyte colony stimulating factor-mobilized leukaphereses differed in frequency and function, suggesting future evaluation of the contribution of CD161(hi) cells in hematopoietic stem cell grafts to transplant outcomes is warranted.

  1. Downregulation of CD44 reduces doxorubicin resistance of CD44+CD24- breast cancer cells

    Directory of Open Access Journals (Sweden)

    Phuc PV

    2011-06-01

    Full Text Available Pham Van Phuc, Phan Lu Chinh Nhan, Truong Hai Nhung, Nguyen Thanh Tam, Nguyen Minh Hoang, Vuong Gia Tue, Duong Thanh Thuy, Phan Kim NgocLaboratory of Stem Cell Research and Application, University of Science, Vietnam National University, Ho Chi Minh, VietnamBackground: Cells within breast cancer stem cell populations have been confirmed to have a CD44+CD24- phenotype. Strong expression of CD44 plays a critical role in numerous types of human cancers. CD44 is involved in cell differentiation, adhesion, and metastasis of cancer cells.Methods: In this study, we reduced CD44 expression in CD44+CD24- breast cancer stem cells and investigated their sensitivity to an antitumor drug. The CD44+CD24- breast cancer stem cells were isolated from breast tumors; CD44 expression was downregulated with siRNAs followed by treatment with different concentrations of the antitumor drug.Results: The proliferation of CD44 downregulated CD44+CD24- breast cancer stem cells was decreased after drug treatment. We noticed treated cells were more sensitive to doxorubicin, even at low doses, compared with the control groups.Conclusions: It would appear that expression of CD44 is integral among the CD44+CD24- cell population. Reducing the expression level of CD44, combined with doxorubicin treatment, yields promising results for eradicating breast cancer stem cells in vitro. This study opens a new direction in treating breast cancer through gene therapy in conjunction with chemotherapy.Keywords: antitumor drugs, breast cancer stem cells, CD44, CD44+CD24- cells, doxorubicin

  2. Applied computational physics

    CERN Document Server

    Boudreau, Joseph F; Bianchi, Riccardo Maria

    2018-01-01

    Applied Computational Physics is a graduate-level text stressing three essential elements: advanced programming techniques, numerical analysis, and physics. The goal of the text is to provide students with essential computational skills that they will need in their careers, and to increase the confidence with which they write computer programs designed for their problem domain. The physics problems give them an opportunity to reinforce their programming skills, while the acquired programming skills augment their ability to solve physics problems. The C++ language is used throughout the text. Physics problems include Hamiltonian systems, chaotic systems, percolation, critical phenomena, few-body and multi-body quantum systems, quantum field theory, simulation of radiation transport, and data modeling. The book, the fruit of a collaboration between a theoretical physicist and an experimental physicist, covers a broad range of topics from both viewpoints. Examples, program libraries, and additional documentatio...

  3. Study of the TAF 2012 DriveLine (CV-CD

    Directory of Open Access Journals (Sweden)

    Alexandru POZDÎRCĂ

    2016-06-01

    Full Text Available TAF is the acronym for Articulated Forestry Tractor – a heavy vehicle uses in a logging operation for pulling cut trees out of a forest, in a process called “skidding”. TAF use a cardan shafts transmission from the gear box (CV to distribution box (CD. The distribution box split the movement thru axels or winch. The study applied the cardan theory on a specific case and based on the numeric results a few design modifications are proposed for reducing the angular velocity pulse on the CD input shaft. Theoretical results may have a significant importance in practice, impacting the reduction of transmission noise and vibrations - already claimed in the case of the distribution box for the current constructive solution. An original AutoLISP program are made in order to analyze and optimize the transmission, with graphical results.

  4. The Andrews’ Principles of Risk, Need, and Responsivity as Applied in Drug Abuse Treatment Programs: Meta-Analysis of Crime and Drug Use Outcomes

    Science.gov (United States)

    Prendergast, Michael L.; Pearson, Frank S.; Podus, Deborah; Hamilton, Zachary K.; Greenwell, Lisa

    2013-01-01

    Objectives The purpose of the present meta-analysis was to answer the question: Can the Andrews principles of risk, needs, and responsivity, originally developed for programs that treat offenders, be extended to programs that treat drug abusers? Methods Drawing from a dataset that included 243 independent comparisons, we conducted random-effects meta-regression and ANOVA-analog meta-analyses to test the Andrews principles by averaging crime and drug use outcomes over a diverse set of programs for drug abuse problems. Results For crime outcomes, in the meta-regressions the point estimates for each of the principles were substantial, consistent with previous studies of the Andrews principles. There was also a substantial point estimate for programs exhibiting a greater number of the principles. However, almost all of the 95% confidence intervals included the zero point. For drug use outcomes, in the meta-regressions the point estimates for each of the principles was approximately zero; however, the point estimate for programs exhibiting a greater number of the principles was somewhat positive. All of the estimates for the drug use principles had confidence intervals that included the zero point. Conclusions This study supports previous findings from primary research studies targeting the Andrews principles that those principles are effective in reducing crime outcomes, here in meta-analytic research focused on drug treatment programs. By contrast, programs that follow the principles appear to have very little effect on drug use outcomes. Primary research studies that experimentally test the Andrews principles in drug treatment programs are recommended. PMID:24058325

  5. Dissociation mechanisms and dynamics of doubly charged CD3CN observed by PEPIPICO spectroscopy

    International Nuclear Information System (INIS)

    Harada, C.; Tada, S.; Yamamoto, K.; Senba, Y.; Yoshida, H.; Hiraya, A.; Wada, S.; Tanaka, K.; Tabayashi, K.

    2006-01-01

    Dissociation of free acetonitrile-d 3 molecule, CD 3 CN induced by core level excitation was studied near the nitrogen K-edge by time-of-flight fragment mass spectroscopy. A variety of atomic and molecular fragment cations such as D + , CD n + , C 2 D n + , and CD n CN + were detected using the effusive CD 3 CN beam. Photoelectron-photoion-photoion coincidence technique was applied to analyse the dissociation mechanisms and dynamics of doubly charged CD 3 CN 2+ following the N(1s-π * ) excitation. The charge separation mechanisms of core-excited CD 3 CN were discussed in connection with Auger final state distributions

  6. Role of ZnO photoanode nanostructures and sensitizer deposition approaches on the photovoltaic properties of CdS/CdSe and CdS1-xSex quantum dot-sensitized solar cells

    Science.gov (United States)

    Şişman, İlkay; Tekir, Oktay; Karaca, Hüseyin

    2017-02-01

    Hierarchical bundle-like ZnO nanorod arrays (BNRs) were synthesized by a one-pot hydrothermal method based on two consecutive temperature steps for cascade CdS/CdSe and ternary CdS1-xSex alloy quantum dot-sensitized solar cells (QDSSCs) as photoanode. The CdS/CdSe and CdS1-xSex QDs were deposited on the surface of the ZnO BNRs by conventional and modified successive ionic-layer adsorption and reaction (SILAR) methods, respectively. Using the ZnO BNRs/CdS/CdSe photoanode, the power conversion efficiency reaches 2.08%, which is 1.8 times higher than that of pristine ZnO nanorods/CdS/CdSe photoanode, while by applying ZnO BNRs/CdS1-xSex, the power conversion efficiency improves 2.52%. The remarkably improved photovoltaic performance is mainly derived from the bundle-like nanorod arrays structure, which increases the QDs loading amount and the scattering effect for light absorption, and the appropriate conduction band energy, sufficient Se amount and well coverage of the ternary CdS1-xSex QDs result in enhanced photogenerated electron injection, high light absorption and reduced recombination, respectively. As a result, ZnO BNRs/CdS1-xSex combination can significantly improve performance of QDSSCs.

  7. CD-ROM Stress.

    Science.gov (United States)

    Bunge, Charles A.

    1991-01-01

    Discussion of stress in library reference departments focuses on stress caused by CD-ROM reference tools. Topics discussed include work overload; nonreference duties; patron attitudes and behavior; staff attitudes; the need for proper staff training; and the need for library administrators to be sensitive to reference staff needs. (LRW)

  8. Haptoglobin and CD163

    DEFF Research Database (Denmark)

    Madsen, M; Graversen, Jonas Heilskov; Moestrup, S K

    2001-01-01

    The plasma protein haptoglobin and the endocytic hemoglobin receptor HbSR/CD163 are key molecules in the process of removing hemoglobin released from ruptured erythrocytes. Hemoglobin in plasma is instantly bound with high affinity to haptoglobin--an interaction leading to the recognition of the ...

  9. Review of CD Rom

    African Journals Online (AJOL)

    "The Virtual Surgeon consists of a ground breaking series of CD-ROMs, which aims to provide surgeons with a new and powerful training tool. It provides surgeons with the most accurate and realistic model of the knee available, and our developments in animation allow them to see all aspects of the surgical procedure.

  10. Applying social marketing principles to understand the effects of the radio diaries program in reducing HIV/AIDS stigma in Malawi.

    Science.gov (United States)

    Rimal, Rajiv N; Creel, Alisha H

    2008-01-01

    Relatively little is known about the extent to which health campaigns can play a constructive role in reducing HIV/AIDS-related stigma. The Malawi Radio Diaries is a program in which HIV-positive men and women openly discuss day-to-day events in their lives with the goal of reducing stigma in the population. Adopting a social marketing perspective, we analyze the various components of the Radio Diaries program in terms of three of the "Four P's": product (stigma reduction), place (radio), and promotion (the program itself). We first investigated the important dimensions of stigma and then developed a model to test the demographic and psychosocial correlates of these dimensions. A midterm household survey was then used to determine the relationship between exposure to the Radio Diaries program and stigma. In multivariate analyses, lower education and knowledge were associated with stronger beliefs that persons living with HIV should be isolated from others. Exposure to the Radio Diaries program did not have a main-effect on stigma, but there was a significant interaction between exposure and efficacy to reduce number of partners such that there was little difference in stigma by exposure level for those with low efficacy, but a significant difference by exposure level for those with high efficacy. Findings are discussed in terms of social marketing principles.

  11. Fiscal 1998 New Sunshine Program achievement report. Development for practical application of photovoltaic system - Development of thin-film solar cell manufacturing technology (Development of low-cost/large-area module manufacturing technology - Development of high-reliability CdS/CdTe solar cell module manufacturing technology); 1998 nendo taiyoko hatsuden system jitsuyoka gijutsu kaihatsu seika hokokusho. Usumaku taiyo denchi no seizo gijutsu kaihatsu / tei cost daimenseki module seizo gijutsu kaihatsu (koshinraisei CdTe taiyo denchi module no seizo gijutsu kaihatsu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    Cost reduction for the above-named solar cells is the aim of this effort. On the basis of the results of past studies, a technology is established of fabricating a thin CdS film by subjecting a CdS film to organometal pyrolysis, and this brings about a decrease in photoabsorption loss in the range of waves shorter than 500nm and a decrease in in-film reflection loss for an increase in short-circuit current density. A proximity sublimation method is used for CdTe film fabrication, which improves on film quality and film adhesion. These efforts result in the achievement of a conversion efficiency of 16.0% which is the highest in the world. Studies are promoted in a process nearer to the ultimate form, and a 30cm times 60cm large CdTe solar cell is fabricated on the basis of a patterning technique, and the product attains a conversion efficiency of 9.8%. In fiscal 1998, studies center about the establishment of a film fabrication process for a medium-are substrate and about the enhancement of its conversion efficiency, and facilities capable of dealing with large-area substrates are introduced and operated. In a typical achievement, a CdTe solar cell is experimentally fabricated in a process which is wholly under normal pressure, and the product with an aperture area of 1376cm{sup 2} exhibits a conversion efficiency of 10.5% according to JQA (Japan Quality Assurance Organization). (NEDO)

  12. Chemical research projects office functions accomplishments programs. [applied research in the fields of polymer chemistry and polymeric composites with emphasis on fire safety

    Science.gov (United States)

    Heimbuch, A. H.; Parker, J. A.

    1975-01-01

    Basic and applied research in the fields of polymer chemistry, polymeric composites, chemical engineering, and biophysical chemistry is summarized. Emphasis is placed on fire safety and human survivability as they relate to commercial and military aircraft, high-rise buildings, mines and rapid transit transportation. Materials systems and other fire control systems developed for aerospace applications and applied to national domestic needs are described along with bench-scale and full-scale tests conducted to demonstrate the improvements in performance obtained through the utilization of these materials and fire control measures.

  13. Applied geodesy

    International Nuclear Information System (INIS)

    Turner, S.

    1987-01-01

    This volume is based on the proceedings of the CERN Accelerator School's course on Applied Geodesy for Particle Accelerators held in April 1986. The purpose was to record and disseminate the knowledge gained in recent years on the geodesy of accelerators and other large systems. The latest methods for positioning equipment to sub-millimetric accuracy in deep underground tunnels several tens of kilometers long are described, as well as such sophisticated techniques as the Navstar Global Positioning System and the Terrameter. Automation of better known instruments such as the gyroscope and Distinvar is also treated along with the highly evolved treatment of components in a modern accelerator. Use of the methods described can be of great benefit in many areas of research and industrial geodesy such as surveying, nautical and aeronautical engineering, astronomical radio-interferometry, metrology of large components, deformation studies, etc

  14. Applying a Multiple Screening Program Aided by a Guideline-driven Computerized Decision Support System—A Pilot Experience in Yun-Lin, Taiwan

    Directory of Open Access Journals (Sweden)

    Jou-Wei Lin

    2007-01-01

    Conclusion: A computer-aided screening program driven by the US Preventive Services Task Force recommendations has been successfully implemented in Yun-Lin, Taiwan, and provided useful information about local epidemiology and implications for future health policy making. [J Formos Med Assoc 2007; 106(1:58-68

  15. Applying the disability-adjusted life year to track health impact of social franchise programs in low- and middle-income countries.

    Science.gov (United States)

    Montagu, Dominic; Ngamkitpaiboon, Lek; Duvall, Susan; Ratcliffe, Amy

    2013-01-01

    Developing effective methods for measuring the health impact of social franchising programs is vital for demonstrating the value of this innovative service delivery model, particularly given its rapid expansion worldwide. Currently, these programs define success through patient volume and number of outlets, widely acknowledged as poor reflections of true program impact. An existing metric, the disability-adjusted life years averted (DALYs averted), offers promise as a measure of projected impact. Country-specific and service-specific, DALYs averted enables impact comparisons between programs operating in different contexts. This study explores the use of DALYs averted as a social franchise performance metric. Using data collected by the Social Franchising Compendia in 2010 and 2011, we compared franchise performance, analyzing by region and program area. Coefficients produced by Population Services International converted each franchise's service delivery data into DALYs averted. For the 32 networks with two years of data corresponding to these metrics, a paired t-test compared all metrics. Finally, to test data reporting quality, we compared services provided to patient volume. Social franchising programs grew considerably from 2010 to 2011, measured by services provided (215%), patient volume (31%), and impact (couple-years of protection (CYPs): 86% and DALYs averted: 519%), but not by the total number of outlets. Non-family planning services increased by 857%, with diversification centered in Asia and Africa. However, paired t-test comparisons showed no significant increase within the networks, whether categorized as family planning or non-family planning. The ratio of services provided to patient visits yielded considerable range, with one network reporting a ratio of 16,000:1. In theory, the DALYs averted metric is a more robust and comprehensive metric for social franchising than current program measures. As social franchising spreads beyond family planning

  16. Applying the disability-adjusted life year to track health impact of social franchise programs in low- and middle-income countries

    Science.gov (United States)

    2013-01-01

    Background Developing effective methods for measuring the health impact of social franchising programs is vital for demonstrating the value of this innovative service delivery model, particularly given its rapid expansion worldwide. Currently, these programs define success through patient volume and number of outlets, widely acknowledged as poor reflections of true program impact. An existing metric, the disability-adjusted life years averted (DALYs averted), offers promise as a measure of projected impact. Country-specific and service-specific, DALYs averted enables impact comparisons between programs operating in different contexts. This study explores the use of DALYs averted as a social franchise performance metric. Methods Using data collected by the Social Franchising Compendia in 2010 and 2011, we compared franchise performance, analyzing by region and program area. Coefficients produced by Population Services International converted each franchise's service delivery data into DALYs averted. For the 32 networks with two years of data corresponding to these metrics, a paired t-test compared all metrics. Finally, to test data reporting quality, we compared services provided to patient volume. Results Social franchising programs grew considerably from 2010 to 2011, measured by services provided (215%), patient volume (31%), and impact (couple-years of protection (CYPs): 86% and DALYs averted: 519%), but not by the total number of outlets. Non-family planning services increased by 857%, with diversification centered in Asia and Africa. However, paired t-test comparisons showed no significant increase within the networks, whether categorized as family planning or non-family planning. The ratio of services provided to patient visits yielded considerable range, with one network reporting a ratio of 16,000:1. Conclusion In theory, the DALYs averted metric is a more robust and comprehensive metric for social franchising than current program measures. As social

  17. Applying radiation

    International Nuclear Information System (INIS)

    Mallozzi, P.J.; Epstein, H.M.; Jung, R.G.; Applebaum, D.C.; Fairand, B.P.; Gallagher, W.J.; Uecker, R.L.; Muckerheide, M.C.

    1979-01-01

    The invention discloses a method and apparatus for applying radiation by producing X-rays of a selected spectrum and intensity and directing them to a desired location. Radiant energy is directed from a laser onto a target to produce such X-rays at the target, which is so positioned adjacent to the desired location as to emit the X-rays toward the desired location; or such X-rays are produced in a region away from the desired location, and are channeled to the desired location. The radiant energy directing means may be shaped (as with bends; adjustable, if desired) to circumvent any obstruction between the laser and the target. Similarly, the X-ray channeling means may be shaped (as with fixed or adjustable bends) to circumvent any obstruction between the region where the X-rays are produced and the desired location. For producing a radiograph in a living organism the X-rays are provided in a short pulse to avoid any blurring of the radiograph from movement of or in the organism. For altering tissue in a living organism the selected spectrum and intensity are such as to affect substantially the tissue in a preselected volume without injuring nearby tissue. Typically, the selected spectrum comprises the range of about 0.1 to 100 keV, and the intensity is selected to provide about 100 to 1000 rads at the desired location. The X-rays may be produced by stimulated emission thereof, typically in a single direction

  18. CD ROM 'Natural heritage of Slovakia'

    International Nuclear Information System (INIS)

    Uradnikova, B.

    2005-01-01

    Centre of Environmental Education Geopark ('Centre') applied environmental education into school and out-of-school institutions. The 'Centre' is working in the fields: environmental education, eco-tourism development, presentation of the cultural landscape and world heritage. The CD ROM 'Natural heritage of Slovakia' was created with aim enhancement of environmental awareness, pedagogy, education and development of eco-tourism on the Slovakia. It abets general review about environment, its components, legislative, history and the present day of nature and landscape protection

  19. Electrical properties of CdS/CdTe heterojunctions

    International Nuclear Information System (INIS)

    Chu, T.L.; Chu, S.S.; Ang, S.T.

    1988-01-01

    The electrical properties of n-CdS/p-CdTe heterojunctions depend strongly on the cleanliness of the interface region. In this work, CdTe films were deposited on CdS/glass substrates by close-spaced sublimation (CSS) under various conditions. The dark current-voltage characteristics of the resulting heterojunctions were measured over a wide temperature range, and the capacitance-voltage characteristics were measured in the dark and under illumination. When the CdS surface is in situ cleaned prior to the deposition of the CdTe film, the current transport across the junction is controlled by a thermally activated process. Tunneling makes an important contribution to the interface recombination at temperatures below room temperature when the in situ cleaning of CdS is not used. The dark capacitance of CdS/CdTe heterojunctions prepared with in situ etching is essentially independent of the reverse bias due to intrinsic interface states. Under white light illumination, the 1/C 2 vs V relation is nearly linear. The CdS/CdTe heterojunctions without in situ cleaning showed different 1/C 2 vs V relations due to higher density of interface states. The in situ cleaning also has pronounced effects on the frequency dependence of dark and illuminated capacitances. Using the in situ cleaning technique, solar cells of about 1 cm 2 area have achieved an AM 1.5 (global) efficiency of about 10.5%

  20. APPLYING LESSONS LEARNED FROM THE UNITED STATES SPECIAL OPERATIONS COMMAND’S HUMAN PERFORMANCE PROGRAM TO THE UNITED STATES AIR FORCES COMPREHENSIVE AIRMAN FITNESS

    Science.gov (United States)

    2016-04-01

    better state of readiness for manning joint sourcing assignments. There is a glass ceiling to the USAF’s physical fitness program’s construct based on... effectiveness of USAF critically manned career fields. A case study framework for comparative analysis of POTFF’s Human Performance Programs in...have huge second and third order effects based on operational requirements to backfill the qualified individual. The investments made into

  1. A qualitative analysis of the performance measurement and outcome management procedures applied to the PLEBE Summer Program at the United States Naval Academy

    OpenAIRE

    Evans, James S.

    2002-01-01

    Approved for public release; distribution is unlimited. The United States Naval Academy is the premier source of officers for the Naval service. It is a four-year total immersion educational experience designed to develop midshipmen morally, mentally, and physically and prepare them for service as either a Naval or Marine Corps officer. The Fourth-Class Indoctrination (Plebe Summer) program is the first military training evolution for most members of the incoming plebe class. The seven-wee...

  2. Multiple dendritic cell populations activate CD4+ T cells after viral stimulation.

    Directory of Open Access Journals (Sweden)

    Adele M Mount

    2008-02-01

    Full Text Available Dendritic cells (DC are a heterogeneous cell population that bridge the innate and adaptive immune systems. CD8alpha DC play a prominent, and sometimes exclusive, role in driving amplification of CD8(+ T cells during a viral infection. Whether this reliance on a single subset of DC also applies for CD4(+ T cell activation is unknown. We used a direct ex vivo antigen presentation assay to probe the capacity of flow cytometrically purified DC populations to drive amplification of CD4(+ and CD8(+ T cells following infection with influenza virus by different routes. This study examined the contributions of non-CD8alpha DC populations in the amplification of CD8(+ and CD4(+ T cells in cutaneous and systemic influenza viral infections. We confirmed that in vivo, effective immune responses for CD8(+ T cells are dominated by presentation of antigen by CD8alpha DC but can involve non-CD8alpha DC. In contrast, CD4(+ T cell responses relied more heavily on the contributions of dermal DC migrating from peripheral lymphoid tissues following cutaneous infection, and CD4 DC in the spleen after systemic infection. CD4(+ T cell priming by DC subsets that is dependent upon the route of administration raises the possibility that vaccination approaches could be tailored to prime helper T cell immunity.

  3. Critical role for thymic CD19+CD5+CD1dhiIL-10+ regulatory B cells in immune homeostasis.

    Science.gov (United States)

    Xing, Chen; Ma, Ning; Xiao, He; Wang, Xiaoqian; Zheng, Mingke; Han, Gencheng; Chen, Guojiang; Hou, Chunmei; Shen, Beifen; Li, Yan; Wang, Renxi

    2015-03-01

    This study tested the hypothesis that besides the spleen, LNs, peripheral blood, and thymus contain a regulatory IL-10-producing CD19(+)CD5(+)CD1d(high) B cell subset that may play a critical role in the maintenance of immune homeostasis. Indeed, this population was identified in the murine thymus, and furthermore, when cocultured with CD4(+) T cells, this population of B cells supported the maintenance of CD4(+)Foxp3(+) Tregs in vitro, in part, via the CD5-CD72 interaction. Mice homozygous for Cd19(Cre) (CD19(-/-)) express B cells with impaired signaling and humoral responses. Strikingly, CD19(-/-) mice produce fewer CD4(+)Foxp3(+) Tregs and a greater percentage of CD4(+)CD8(-) and CD4(-)CD8(+) T cells. Consistent with these results, transfer of thymic CD19(+)CD5(+)CD1d(hi) B cells into CD19(-/-) mice resulted in significantly up-regulated numbers of CD4(+)Foxp3(+) Tregs with a concomitant reduction in CD4(+)CD8(-) and CD4(-)CD8(+) T cell populations in the thymus, spleen, and LNs but not in the BM of recipient mice. In addition, thymic CD19(+)CD5(+)CD1d(hi) B cells significantly suppressed autoimmune responses in lupus-like mice via up-regulation of CD4(+)Foxp3(+) Tregs and IL-10-producing Bregs. This study suggests that thymic CD19(+)CD5(+)CD1d(hi)IL-10(+) Bregs play a critical role in the maintenance of immune homeostasis. © Society for Leukocyte Biology.

  4. In ovo injection of anti-chicken CD25 monoclonal antibodies depletes CD4+CD25+ T cells in chickens.

    Science.gov (United States)

    Shanmugasundaram, Revathi; Selvaraj, Ramesh K

    2013-01-01

    The CD4(+)CD25(+) cells have T regulatory cell properties in chickens. This study investigated the effect of in ovo injection of anti-chicken CD25 monoclonal antibodies (0.5 mg/egg) on CD4(+)CD25(+) cell depletion and on amounts of interleukin-2 mRNA and interferon-γ mRNA in CD4(+)CD25(-) cells posthatch. Anti-chicken CD25 or PBS (control) was injected into 16-d-old embryos. Chicks hatched from eggs injected with anti-chicken CD25 antibodies had a lower CD4(+)CD25(+) cell percentage in the blood until 25 d posthatch. The anti-chicken CD25 antibody injection nearly depleted CD4(+)CD25(+) cells in the blood until 16 d posthatch. At 30 d posthatch, the CD4(+)CD25(+) cell percentage in the anti-CD25-antibody-injected group was comparable with the percentage in the control group. At 16 d posthatch, the anti-chicken CD25 antibody injection decreased CD4(+)CD25(+) cell percentages in the thymus, spleen, and cecal tonsils. Chickens hatched from anti-CD25-antibody-injected eggs had approximately 25% of CD4(+)CD25(+) cells in the cecal tonsils and thymus compared with those in the cecal tonsils and thymus of the control group. The CD4(+)CD25(-) cells from the spleen and cecal tonsils of chicks hatched from anti-chicken-CD25-injected eggs had higher amounts of interferon-γ and interleukin-2 mRNA than CD4(+)CD25(-) cells from the control group. It could be concluded that injecting anti-chicken CD25 antibodies in ovo at 16 d of incubation nearly depleted the CD4(+)CD25(+) cells until 25 d posthatch.

  5. Cadmium accumulation, gill Cd binding, acclimation, and physiological effects during long term sublethal Cd exposure in rainbow trout

    International Nuclear Information System (INIS)

    Hollis, L.; McGeer, J.C.; McDonald, D.G.; Wood, C.M.

    1999-01-01

    Juvenile rainbow trout, on 3% of body weight daily ration, were exposed to 0 (control), 3, and 10 μg l -1 Cd (as Cd(NO 3 ) 2 · 4H 2 O) in moderately hard (140 mg l -1 as CaCO 3 ), alkaline (95 mg l -1 as CaCO 3 , pH 8.0) water for 30 days. Particular attention focused on acclimation, and on whether a gill surface binding model, originally developed in dilute softwater, could be applied in this water quality to fish chronically exposed to Cd. Only the higher Cd concentration caused mortality (30%, in the first few days). The costs of acclimation, if any, in our study were subtle since no significant effects of chronic Cd exposure were seen in growth rate, swimming performance (stamina and U Crit ), routine O 2 consumption, or whole body ion levels. Substantial acclimation occurred in both exposure groups, manifested as 11- to 13-fold increases in 96-h LC 50 values. In water quality regulations, which are based on toxicity tests with non-acclimated fish only, this remarkable protective effect of acclimation is not taken into account. Cd accumulated in a time- and concentration-dependent fashion to 60-120x (gills), 8-20x (liver), 2-7x (carcass), and 5-12x (whole bodies) control levels by 30 days. Chronically accumulated gill Cd could not be removed by ethylenediaminetetraacetic acid (EDTA) challenge. These gill Cd concentrations were 20- to 40-fold greater than levels predicted by the gill-binding model to cause mortality during acute exposure. In short-term gill Cd-binding experiments (up to 70 μg l -1 exposures for 3 h), gill Cd burden increased as predicted in control fish, but was not detectable against the high background concentrations in acclimated fish. In light of these results, Cd uptake/turnover tests were performed using radioactive 109 Cd to improve sensitivity. With this approach, a small saturable binding component was seen, but could not be related to toxic response in acclimated fish. Acclimated trout internalized less 109 Cd than control fish, but

  6. The established mega watt linear programming-based optimal power flow model applied to the real power 56-bus system in eastern province of Saudi Arabia

    International Nuclear Information System (INIS)

    Al-Muhawesh, Tareq A.; Qamber, Isa S.

    2008-01-01

    A current trend in electric power industries is the deregulation around the world. One of the questions arise during any deregulation process is: where will be the future generation expansion? In the present paper, the study is concentrated on the wheeling computational method as a part of mega watt (MW) linear programming-based optimal power flow (LP-based OPF) method. To observe the effects of power wheeling on the power system operations, the paper uses linear interactive and discrete optimizer (LINDO) optimizer software as a powerful tool for solving linear programming problems to evaluate the influence of the power wheeling. As well, the paper uses the optimization tool to solve the economic generation dispatch and transmission management problems. The transmission line flow was taken in consideration with some constraints discussed in this paper. The complete linear model of the MW LP-based OPF, which is used to know the future generation potential areas in any utility is proposed. The paper also explains the available economic load dispatch (ELD) as the basic optimization tool to dispatch the power system. It can be concluded in the present study that accuracy is expensive in terms of money and time and in the competitive market enough accuracy is needed without paying much

  7. Magnetic study of Fe-doped CdSe nanomaterials

    International Nuclear Information System (INIS)

    Das, Sayantani; Banerjee, Sourish; Sinha, T. P.

    2016-01-01

    Nanoparticles of pure and iron (50 %) doped cadmium selenide (CdSe) have been synthesized by soft chemical route. EDAX analysis supports the inclusion of Fe into CdSe nanoparticles. The average particle size of pure and doped CdSe is found to be ∼50 nm from scanning electron microscopy (SEM). Magnetization of the samples are measured under the field cooled (FC) and zero field cooled (ZFC) modes in the temperature range from 5K to 300K applying a magnetic field of 500Oe. Field dependent magnetization (M-H) measurement indicates presence of room temperature (RT) paramagnetism and low temperature (5K) ferromagnetism of the sample.

  8. The Peltier and Zeebeck coefficients of the Cd-CdI2 melt

    International Nuclear Information System (INIS)

    Kuzyakin, E.B.; Kuz'minskij, E.V.

    1979-01-01

    For the CdI 2 -Cd melt with the usage of molybdenum ''inert'' electrodes in the temperature range of 670-850 K and metal cadmium concentration of 0-5 mol % experimentally determined are the Peltier (PI = 0.67+0.07 V at T = 722 K and 0.23 mol %) and Zeebeck (epsilonsub(in) 1.175+-0.107 mV/deg -1 at 0.20 mol % Cd and T = 700-780 K) coefficients. Calculated is heat transfer coefficient from the electrode to the melt (a = 65+-10 W/m 2 K), reaffirmed is applicability of the second Thomson ratio (PI = Txepsilonsub(in)). It is shown that the method of non-stationary temperature waves, suggested for the Peltier coefficient determination can be applied for evaluation of metal solubility values in their molten salts

  9. Novel red-emission of ternary ZnCdSe semiconductor nanocrystals

    Science.gov (United States)

    Chung, Shu-Ru; Wang, Kuan-Wen; Chen, Hong-Shuo; Chen, Hong-Hong

    2015-02-01

    The effect of chain lengths of fatty acids on the physical properties of CdSe and ZnCdSe semiconductor nanocrystals (NCs) synthesized by the colloidal chemistry procedure is investigated. The fatty acids, lauric acid (LA), and stearic acid (SA), with different lengths of carbon chains, are used to prepare CdSe and ZnCdSe NCs when hexyldecylamine (HDA) is applied as the sole surfactant. For CdSe-SA and ZnCdSe-SA, they have the same emission wavelength at 592 nm and the same particle size of 3.3 nm; however, their quantum yield (QY) is 75 and 16 %, respectively. In contrast, the emission wavelength of CdSe-LA and ZnCdSe-LA NCs is 609 and 615 nm, the particle size is about 3.5 and 4 nm under the same reaction time, and the QY of them are 33 and 59 %, respectively. The X-ray diffraction pattern shows that ZnCdSe NCs all have the wurtzite structure, and their main peaks are located between those of pure CdSe and ZnSe materials. The main phase of ZnCdSe-SA and ZnCdSe-LA is ZnSe and CdSe, respectively, implying that alloyed ZnCdSe NC can be prepared and ZnSe and CdSe phase can be promoted by SA and LA, respectively. Moreover, the QY of red-emission ZnCdSe-LA is higher than 50 %. These results suggest that the growth rate of CdSe as well as ZnCdSe NC can be enhanced by using LA as complex reagent and HDA as sole surfactant. It is expected that the reported effective synthetic strategy can be developed as a very practical, easy and not time-consuming approach to prepare red emissive NCs with high QY and high reproducibility.

  10. Applied plasma physics

    International Nuclear Information System (INIS)

    Anon.

    1979-01-01

    Applied Plasma Physics is a major sub-organizational unit of the Magnetic Fusion Energy (MFE) Program. It includes Fusion Plasma Theory and Experimental Plasma Research. The Fusion Plasma Theory group has the responsibility for developing theoretical-computational models in the general areas of plasma properties, equilibrium, stability, transport, and atomic physics. This group has responsibility for giving guidance to the mirror experimental program. There is a formal division of the group into theory and computational; however, in this report the efforts of the two areas are not separated since many projects have contributions from members of both. Under the Experimental Plasma Research Program we are developing a neutral-beam source, the intense, pulsed ion-neutral source (IPINS), for the generation of a reversed-field configuration on 2XIIB. We are also studying the feasibility of using certain neutron-detection techniques as plasma diagnostics in the next generation of thermonuclear experiments

  11. Applied plasma physics

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    Applied Plasma Physics is a major sub-organizational unit of the MFE Program. It includes Fusion Plasma Theory and Experimental Plasma Research. The Fusion Plasma Theory group has the responsibility for developing theoretical-computational models in the general areas of plasma properties, equilibrium, stability, transport, and atomic physics. This group has responsibility for giving guidance to the mirror experimental program. There is a formal division of the group into theory and computational; however, in this report the efforts of the two areas are not separated since many projects have contributions from members of both. Under the Experimental Plasma Research Program, we are developing the intense, pulsed neutral-beam source (IPINS) for the generation of a reversed-field configuration on 2XIIB. We are also studying the feasibility of utilizing certain neutron-detection techniques as plasma diagnostics in the next generation of thermonuclear experiments

  12. Applied chemical engineering thermodynamics

    CERN Document Server

    Tassios, Dimitrios P

    1993-01-01

    Applied Chemical Engineering Thermodynamics provides the undergraduate and graduate student of chemical engineering with the basic knowledge, the methodology and the references he needs to apply it in industrial practice. Thus, in addition to the classical topics of the laws of thermodynamics,pure component and mixture thermodynamic properties as well as phase and chemical equilibria the reader will find: - history of thermodynamics - energy conservation - internmolecular forces and molecular thermodynamics - cubic equations of state - statistical mechanics. A great number of calculated problems with solutions and an appendix with numerous tables of numbers of practical importance are extremely helpful for applied calculations. The computer programs on the included disk help the student to become familiar with the typical methods used in industry for volumetric and vapor-liquid equilibria calculations.

  13. Why language matters: insights and challenges in applying a social determination of health approach in a North-South collaborative research program.

    Science.gov (United States)

    Spiegel, Jerry M; Breilh, Jaime; Yassi, Annalee

    2015-02-27

    Focus on "social determinants of health" provides a welcome alternative to the bio-medical illness paradigm. However, the tendency to concentrate on the influence of "risk factors" related to living and working conditions of individuals, rather than to more broadly examine dynamics of the social processes that affect population health, has triggered critical reaction not only from the Global North but especially from voices the Global South where there is a long history of addressing questions of health equity. In this article, we elaborate on how focusing instead on the language of "social determination of health" has prompted us to attempt to apply a more equity-sensitive approaches to research and related policy and praxis. In this debate, we briefly explore the epistemological and historical roots of epidemiological approaches to health and health equity that have emerged in Latin America to consider its relevance to global discourse. In this region marked by pronounced inequity, context-sensitive concepts such as "collective health" and "critical epidemiology" have been prominent, albeit with limited acknowledgement by the Global North. We illustrate our attempts to apply a social determination approach (and the "4 S" elements of bio-Security, Sovereignty, Solidarity and Sustainability) in five projects within our research collaboration linking researchers and knowledge users in Ecuador and Canada, in diverse settings (health of healthcare workers; food systems; antibiotic resistance; vector borne disease [dengue]; and social circus with street youth). We argue that the language of social determinants lends itself to research that is more reductionist and beckons the development of different skills than would be applied when adopting the language of social determination. We conclude that this language leads to more direct analysis of the systemic factors that drive, promote and reinforce disparities, while at the same time directly considering the emancipatory

  14. Systematic Protein-Protein Docking and Molecular Dynamics Studies of HIV-1 gp120 and CD4: Insights for New Drug Development

    Directory of Open Access Journals (Sweden)

    M. Rizman-Idid

    2011-12-01

    Full Text Available Background and the purpose of the study: The interactions between HIV-1 gp120 and mutated CD4 proteins were investigated in order to identify a lead structure for therapy based on competitive blocking of the HIV binding receptor for human T-cells. Crystal structures of HIV gp120-CD4 complexes reveal a close interaction of the virus receptor with CD4 Phe43, which is embedded in a pocket of the virus protein.Methods: This study applies computer simulations to determine the best binding of amino acid 43 CD4 mutants to HIV gp120. Besides natural CD4, three mutants carrying alternate aromatic residues His, Trp and Tyr at position 43 were investigated. Several docking programs were applied on isolated proteins based on selected crystal structures of gp120-CD4 complexes, as well as a 5 ns molecular dynamics study on the protein complexes. The initial structures were minimized in Gromacs to avoid crystal packing effects, and then subjected to docking experiments using AutoDock4, FireDock, ClusPro and ZDock. In molecular dynamics, the Gibbs free binding energy was calculated for the gp120-CD4 complexes. The docking outputs were analyzed on energy within the respective docking software.Results and conclusion: Visualization and hydrogen bonding analysis were performed using the Swiss-PdbViewer. Strong binding to HIV gp120 can be achieved with an extended aromatic group (Trp. However, the sterical demand of the interaction affects the binding kinetics. In conclusion, a ligand for an efficient blocking of HIV gp120 should involve an extended but conformational flexible aromatic group, i.e. a biphenyl. A docking study on biphenylalanine-43 confirms this expectation

  15. Enhancing the effectiveness of HIV/AIDS prevention programs targeted to unique population groups in Thailand: lessons learned from applying concepts of diffusion of innovation and social marketing.

    Science.gov (United States)

    Svenkerud, P J; Singhal, A

    1998-01-01

    Diffusion of innovations theory and social marketing theory have been criticized for their limited applicability in influencing unique population groups (e.g., female commercial sex workers (CSWs) working in low-class brothels). This study investigated the applicability of these two theoretical frameworks in outreach efforts directed to unique populations at high risk for HIV/AIDS in Bangkok, Thailand. Further, this study examined Thai cultural characteristics that influence communication about HIV/AIDS prevention. The results suggest that certain concepts and strategies drawn from the two frameworks were used more or less by effective outreach programs, providing several policy-relevant lessons. Cultural constraints, such as the lack of visibility of the disease and traditional sexual practices, influenced communication about HIV/AIDS prevention.

  16. Applying human factors engineering program to the modernization project of NPP Control Room in accordance with U.S.NRC and KTA regulations

    International Nuclear Information System (INIS)

    Avellar, Renato Koga de; Schirru, Roberto

    2017-01-01

    Application of Human Factors Engineering (HFE) in the design and implementation of such a project is essential to ensure that the new man-machine interface outcoming from the modernization does not have any negative impacts on human performance and plant safety. This paper analyzes the applicability of the Human Factors Engineering Program in the licensing and certification of Konvoi Nucleoelectric Power Plant Control Room Modernization Project using digital instrumentation and control in accordance with U.S.NRC and KTA regulations. The results of the analyses show that although regulatory bodies adopt different methodology in the process of licensing the modernization of control rooms, the engineering aspects are being developed based on the principles of engineering. (author)

  17. Applying human factors engineering program to the modernization project of NPP Control Room in accordance with U.S.NRC and KTA regulations

    Energy Technology Data Exchange (ETDEWEB)

    Avellar, Renato Koga de, E-mail: rkoga@eletronuclear.gov.br [Eletrobrás Termonuclear S.A. (ELETRONUCLEAR), Rio de Janeiro, RJ (Brazil). Assessoria de Licenciamento Nuclear e Ambiental; Schirru, Roberto, E-mail: schirru@lmp.ufrj.br [Coordenacao de Pos-Graduacao e Pesquisa de Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear

    2017-07-01

    Application of Human Factors Engineering (HFE) in the design and implementation of such a project is essential to ensure that the new man-machine interface outcoming from the modernization does not have any negative impacts on human performance and plant safety. This paper analyzes the applicability of the Human Factors Engineering Program in the licensing and certification of Konvoi Nucleoelectric Power Plant Control Room Modernization Project using digital instrumentation and control in accordance with U.S.NRC and KTA regulations. The results of the analyses show that although regulatory bodies adopt different methodology in the process of licensing the modernization of control rooms, the engineering aspects are being developed based on the principles of engineering. (author)

  18. Engaging HIV-infected patients in antiretroviral therapy services: CD4 cell count testing after HIV diagnosis from 2005 to 2009 in Yunnan and Guangxi, China

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yao; Ray Y. Chen; ZHANG Fu-jie; LU Lin; LI Hui-qin; LIU Wei; TANG Zhi-rong; FANG Hua; Jennifer Y. Chen; MA Ye; ZHAO Yan

    2011-01-01

    Background The initiation and expansion of China's national free antiretroviral therapy program has led to significant improvement of survival among its participants. Success of further scaling up treatment coverage rests upon intensifying HIV screening and efficient linkage of care. Timely CD4 cell count testing after HIV diagnosis is necessary to determine whether a patient meets criteria for antiretroviral treatment, and represents a crucial link to engage HIV-infected patients in appropriate care, which has not been evaluated in China.Methods We evaluated all patients ≥16 years who tested HIV positive from 2005 to 2009 in Yunnan and Guangxi.Multivariate Logistic regression models were applied to identify factors associated with lack of CD4 cell count testing within 6 months after HIV diagnosis.Results A total of 83 556 patients were included. Over the study period, 30 635 (37%) of subjects received a CD4 cell count within 6 months of receiving the HIV diagnosis. The rate of CD4 cell count testing within 6 months of HIV diagnosis increased significantly from 7% in 2005 to 62% in 2009. Besides the earlier years of HIV diagnosis, negative predictors for CD4 cell count testing in multivariate analyses included older age, not married or unclear marriage status,incarceration, diagnosis at sexual transmitted disease clinics, mode of HIV transmission classified as men who have sex with men, intravenous drug users or transmission route unclear, while minority ethnicity, receipt of high school or higher education, diagnosis at voluntary counseling and testing clinics, and having HIV positive parents were protective.Conclusions Significant progress has been made in increasing CD4 testing among newly diagnosed HIV positive patients in Yunnan and Guangxi from 2005-2009. However, a sizable proportion of HIV positive patients still lack CD4testing within 6 months of diagnosis. Improving CD4 testing, particularly among patients with identified risk factors, is essential to

  19. Dose reader CD-02

    International Nuclear Information System (INIS)

    Jakowiuk, A.; Kaluska, I.; Machaj, B.

    2005-01-01

    Dose Reader CD-02 is designed for measurement of dose from a long narrow band of dosimetric foil used for check up and control of electron beam dose during sterilization of materials and products on conveyor belt. Irradiated foil after processing (heating) is inserted into foil driving (moving) system and when the foil is moved across focused light beam the absorbed dose is measured and displayed at the same time at computer monitor (in form of a diagram). The absorbed dose is measured on the principle of light attenuation at selected light wavelength (foil absorbance is measured). (author)

  20. Impacts of rapeseed dregs on Cd availability in contaminated acid soil and Cd translocation and accumulation in rice plants.

    Science.gov (United States)

    Yang, Wen-Tao; Gu, Jiao-Feng; Zou, Jia-Ling; Zhou, Hang; Zeng, Qing-Ru; Liao, Bo-Han

    2016-10-01

    The objective of the present study was to investigate the effects of rapeseed dregs (RSD, a commonly organic fertilizer in rural China) at application rates of 0, 0.75, 1.5, and 3.0 % on Cd availability in soil and its accumulation in rice plants (Oryza sativa L., Xiangwanxian 12 # , and Weiyou 46 # ) by means of a pot experiment. The results showed that application of RSD resulted in a sharp decrease in the soil TCLP-extractable Cd content. However, the soil TCLP-extractable Cd content in amended soil gradually increased during the rice growing period. Application of RSD significantly increased Cd transport from root to shoot and the amount of Cd accumulated in the aerial part. RSD was an effective organic additive for increasing rice grain yield, but total Cd content in rice grain was also increased. At an application rate of 1.5-3.0 % RSD, the total Cd content in Weiyou 46 # brown rice was 0.27-0.31 mg kg -1 , which exceeded the standard safe limit (0.2 mg kg -1 ) and was also higher than that of Xiangwanxian 12 # (0.04-0.14 mg kg -1 ). Therefore, Weiyou 46 # had a higher dietary risk than Xiangwanxian 12 # with RSD application. We do not recommend planting Weiyou 46 # and applying more than 0.75 % RSD in Cd-contaminated paddy fields.

  1. Validation of the computer code system ATHLET / ATHLET-CD. Final report; Validierung des Rechenprogrammsystems ATHLET / ATHLET-CD. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Austregesilo, H.; Bals, C.; Erdmann, W.; Horche, W.; Krzykacz-Hausmann, B.; Pointner, W.; Schoeffel, P.; Skorek, T.; Weber, S.; Wielenberg, A.

    2010-04-15

    In the frame of the reactor safety project RS1173, sponsored by the German Federal Ministry of Economics and Technology, analyses of international integral and separate effects tests have been performed for the validation of the code system ATHLET/ATHLET-CD. The work mainly comprised post-test calculations of selected experiments and the contributions to the working groups accompanying the experimental programs. For the assessment of the thermal-hydraulic models in ATHLET 8 integral tests and 4 separate effect tests have been considered. Together with the corroboration of the existing models, the validation analyses were mainly dedicated to the assessment of the modelling of non-condensable gases and their influence on two-phase natural circulation and on the primary heat removal through steam generators, as well as of the simulation of multi-dimensional flow processes. The validation calculations with respect to the simulation of multi-dimensional one- and two-phase flows aimed to investigate the range of applicability and limitations of the method of parallel channels in connection with the separate momentum equations for water and steam current used in ATHLET as well as to assess the status of the coupled version ATHLET/FLUBOX-3D. The ATHLET-CD validation analyses included the post-test calculations of 9 bundle tests, and was mainly focussed on the assessment of the improved and new models for core degradation, including the models for oxidation, melt formation and relocation for BWR components, as well as of the modelling of fission products and aerosol transport within the primary circuit taking into account chemical reactions within the module SOPHAEROS. As an additional contribution to code validation, the GRS methodology of uncertainty and sensitivity analysis was applied exemplarily to two validation calculations, one with ATHLET and one with ATHLET-CD. The results of these uncertainty analyses endorse the capability of the code system to reproduce

  2. Clean focus, dose and CD metrology for CD uniformity improvement

    Science.gov (United States)

    Lee, Honggoo; Han, Sangjun; Hong, Minhyung; Kim, Seungyoung; Lee, Jieun; Lee, DongYoung; Oh, Eungryong; Choi, Ahlin; Kim, Nakyoon; Robinson, John C.; Mengel, Markus; Pablo, Rovira; Yoo, Sungchul; Getin, Raphael; Choi, Dongsub; Jeon, Sanghuck

    2018-03-01

    Lithography process control solutions require more exacting capabilities as the semiconductor industry goes forward to the 1x nm node DRAM device manufacturing. In order to continue scaling down the device feature sizes, critical dimension (CD) uniformity requires continuous improvement to meet the required CD error budget. In this study we investigate using optical measurement technology to improve over CD-SEM methods in focus, dose, and CD. One of the key challenges is measuring scanner focus of device patterns. There are focus measurement methods based on specially designed marks on scribe-line, however, one issue of this approach is that it will report focus of scribe line which is potentially different from that of the real device pattern. In addition, scribe-line marks require additional design and troubleshooting steps that add complexity. In this study, we investigated focus measurement directly on the device pattern. Dose control is typically based on using the linear correlation behavior between dose and CD. The noise of CD measurement, based on CD-SEM for example, will not only impact the accuracy, but also will make it difficult to monitor dose signature on product wafers. In this study we will report the direct dose metrology result using an optical metrology system which especially enhances the DUV spectral coverage to improve the signal to noise ratio. CD-SEM is often used to measure CD after the lithography step. This measurement approach has the advantage of easy recipe setup as well as the flexibility to measure critical feature dimensions, however, we observe that CD-SEM metrology has limitations. In this study, we demonstrate within-field CD uniformity improvement through the extraction of clean scanner slit and scan CD behavior by using optical metrology.

  3. Increased Numbers of CD4+CD25+ and CD8+CD25+ T-Cells in Peripheral Blood of Patients with Rheumatoid Arthritis with Parvovirus B19 Infection.

    Science.gov (United States)

    Naciute, Milda; Maciunaite, Gabriele; Mieliauskaite, Diana; Rugiene, Rita; Zinkeviciene, Aukse; Mauricas, Mykolas; Murovska, Modra; Girkontaite, Irute

    2017-01-01

    To investigate T-cell subpopulations in peripheral blood of human parvovirus B19 DNA-positive (B19 + ) and -negative (B19 - ) patients with rheumatoid arthritis (RA) and healthy persons. Blood samples were collected from 115 patients with RA and 47 healthy volunteers; 27 patients with RA and nine controls were B19 + Cluster of differentiation (CD) 4, 8, 25 and 45RA were analyzed on blood cells. CD25 expression on CD4 + CD45RA + , CD4 + CD45RA - , CD8 + CD45RA + , CD8 + CD45RA - subsets were analyzed by flow cytometry. The percentage of CD25 low and CD25 hi cells was increased on CD4 + CD45RA + , CD4 + CD45RA - T-cells and the percentage of CD25 + cells was increased on CD8 + CD45RA + , CD8 + CD45RA - T-cells of B19 + patients with RA in comparison with B19 - patients and controls. Raised levels of CD4 and CD8 regulatory T-cells in B19 + RA patients could cause down-regulation of antiviral clearance mechanisms and lead to activation of persistent human parvovirus B19 infection in patients with RA. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  4. Optimization programs of radiation protection applied to post-graduation and encouraging research; Programas de otimizacao da protecao radiologica aplicados a pos-graduacao e o incentivo a pesquisa

    Energy Technology Data Exchange (ETDEWEB)

    Levy, Denise S., E-mail: denise@omiccron.com.br [Omiccron Programacao Grafica, Sao Paulo, Atibaia, SP (Brazil); Sordi, Gian Maria A.A., E-mail: adelia@atomo.com.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    In 2011 we started the automation and integration of radiological protection optimization programs, in order to offer unified programs and inter-related information in Portuguese, providing Brazilian radioactive facilities a complete repository for research, consultation and information. The authors of this project extended it to postgraduate education, in order to encourage postgraduate students researches, expanding methods for enhancing student learning through the use of different combined resources, such as educational technology, information technology and group dynamics. This new methodology was applied in a postgraduate discipline at Instituto de Pesquisas Energeticas e Nucleares (IPEN), Brazil, in the postgraduate discipline entitled Fundamental Elements of Radiological Protection (TNA-5732). Students have six weeks to assimilate a complex content of optimization, considering national and international standards, guidelines and recommendations published by different organizations over the past decades. Unlike traditional classes, in which students receive prompt responses, this new methodology stimulates discussion, encouraging collective thinking processes and promoting ongoing personal reflection and researches. Case-oriented problem-solving permitted students to play different roles, promoting whole-group discussions and cooperative learning, approaching theory and practical applications. Students discussed different papers, published in international conferences, and their implications according to current standards. The automation of optimization programs was essential as a research tool during the course. The results of this experience were evaluated in two consecutive years. We had excellent results compared to the previous 14 years. The methodology has exceeded expectations and will be also applied in 2013 to ionizing radiation monitoring postgraduate classes. (author)

  5. Fatty acid composition of soybean/sunflower mix oil, fish oil and butterfat applying the AOCS Ce 1j-07 method with a modified temperature program

    Directory of Open Access Journals (Sweden)

    Masson, L.

    2015-03-01

    Full Text Available Gas-Liquid Chromatography (GLC methods such as AOAC Fat in foods 966.06 (2005, AOCS Official Methods Ce 1h-05 (2005, Ce 1j-07 (2007, allow for analyzing the fatty acids (FAs in dietary fats using highly polar liquid phase capillary columns. However, there are still difficulties in completely separating butiric acid from solvent, FA critical pairs with similar polarity, conjugated linoleic acid (CLA isomers, and long chainpolyunsaturated FAs (LC-PUFAs. Therefore, the selection of the temperature program to be employed is important. This work aimed to improve the AOCS Ce 1j-07 Method for the FA composition of a mixture of soybean and sunflower oil, fish oil, and butterfat, using a modified temperature program, tested among five laboratories. It takes more time, but it allows to completely separate butyric acid from the solvent, trans-18:1 from cis-18:1, 20:1 isomers from 18:3 n-3, 22:1 n-9 from 20:4 n-6, 20:5 n-3 from 24:0 and the main CLA isomers, thus permitting FA quantification in fats and oils for different purposes such as nutritional labeling, quality control and research.Métodos por cromatografía gas-líquido, AOAC 966.06 (2005, AOCS Ce 1h-05 (2005, Ce 1j-07 (2007 permiten determinar ácidos grasos (AG en matrices grasas usando columnas capilares altamente polares y distintos programas de temperatura. No obstante, aún existen dificultades para separar ácido butírico del solvente, pares críticos de AG con polaridades similares, isómeros del ácido linoleico conjugado (CLA, AG de cadena larga poliinsaturados (LC-PUFAs. El objetivo fue mejorar el Método AOCS Ce 1j-07 aplicándolo a la composición en AG de mezcla de aceite soja/girasol, aceite de pescado, mantequilla, usando un programa de temperatura modificado, entre cinco laboratorios. El programa de temperatura elegido, si bien emplea más tiempo, permite separar completamente ácido butírico del solvente, trans-18:1 de cis-18:1, isómeros 20:1 de 18:3 n-3, 22:1 n-9 de 20:4 n-6

  6. New Sunshine Program for fiscal 2000. Development of photovoltaic system commercialization technology - Development of thin-film solar cell manufacturing technology - Development of low-cost/large area module manufacturing technology (Development of high-reliability CdTe solar cell module manufacturing technology); 2000 nendo New sunshine keikaku seika hokokusho. Taiyoko hatsuden system jitsuyoka gijutsu kaihatsu, Hakumaku taiyodenchi no seizo gijutsu kaihatsu, Tei cost dai menseki mojuru seizo gijutsu kaihatsu (Koshinraisei CdTe taiyo denchi mojuru no seizo gijutsu kaihatsu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    Research and development was conducted for reliable CdTe solar cell modules, large in area and high in efficiency. In the study of large-area CdS thin film fabrication, a conversion efficiency of 12.5-14.2% was achieved in a cell in a large-area substrate using a mist method-aided process of continuous CdS film fabrication. In the study of large-area CdTe thin film fabrication, the optimization was studied of the base-forming CdS film fabrication conditions and of the CdTe film fabrication conditions in a method using a CdTe powder processed by dry kneading, and a conversion efficiency peak was found to exist when the CdS film thickness was in the range of 700-900 angstrom. In the fabrication of large-area submodules, a large-area substrate was taken up, and TCO (transparent conducting oxide) film was fabricated by the mist method, CdTe film by the normal pressure CSS method, electrodes by the screen printing method, and CdTe film patterns by the blast method. As the result, a conversion efficiency of 11.0% was achieved. In a cost estimation for large-area CdTe solar cell modules, 140 yen/Wp (conversion efficiency: 11.0%, annual production: 100 MW) was obtained. (NEDO)

  7. Changes and clinical significance of CD4+CD25+CD127- regulatory T cells in Graves disease

    International Nuclear Information System (INIS)

    Zou Jintao; Yu Peiling; Dong Jingwei; Liao Qihong; Liu Dongliang; Zeng Hongyi

    2012-01-01

    Objective: To investigate the mechanism of Graves disease by observing the changes of CD4 + CD25 + CD127 - regulatory T cells (Treg) population in the patients. Methods: Flow cytometry was used to detect the proportion of CD4 + CD25 + CD127 - Treg of CD4 + T cells in 90 Graves disease patients (Graves disease group) and 50 healthy adults (control group). Thyroid function and autoantibody levels were determined simultaneously. The t test was adopted for comparison between groups. The relationship between CD4 + CD25 + CD127 - Treg and thyroid function was analyzed by linear correlation analysis. Results: The percentages of CD4 + CD25 + CD127 - Treg in Graves disease group and control group were 1.39%±1.09% and 4.59%±1.14% separately. There was significant difference between the two groups (t=16.4, P<0.01). There were negative correlation between CD4 + CD25 + CD127 - Treg percentages and total triiodothyronine, total thyroxine,free triiodothyronine, free thyroxine and thyrotropin receptor antibody,thyroglobulin antibody, thyroid microsomal antibody (r=-0.62, -0.65, -0.56, -0.71, -0.50, -0.15, all P<0.01). Conclusions: The reduction of CD4 + CD25 + CD127 - Treg percentages in Graves disease group and close relations of CD4 + CD25 + CD127 - Treg with thyroid function and thyroid autoantibody levels suggest that CD4 + CD25 + CD127 - Treg decrease in the number may be associated with the onset of Graves disease. CD4 + CD25 + CD127 - may be the specific marker of Treg. (authors)

  8. Educational Geographers and Applied Geography.

    Science.gov (United States)

    Frazier, John W.

    1979-01-01

    Describes the development of applied geography programs and restructuring of curricula with an emphasis on new technique and methodology courses, though retaining the liberal arts role. Educational geographers can help the programs to succeed through curriculum analysis, auditing, advising students, and liaison with other geography sources. (CK)

  9. From rags to riches in the world of NEPA: The Hanford Site experience in applying the Department of Energy's NEPA program

    International Nuclear Information System (INIS)

    Guzzetta, D.J.

    1995-01-01

    The Department of Energy's procedures for implementing the requirements of the National Environmental Policy Act (NEPA) have undergone significant changes since February 5, 1990 when the then Secretary of Energy, Admiral James Watkins, issued Secretary of Energy Notice 15 (SEN-15). This notice directed all DOE elements to integrate NEPA into their decision making processes and temporarily centralized NEPA decision making for all level of NEPA documents (categorical exclusions, environmental assessments (EA), and environmental impact statements) at DOE Headquarters. Since 1990 most of the responsibilities for NEPA have been returned to DOE field elements. However, in the intervening five years, there have been significant changes at all levels of DOE regarding the role NEPA will play in DOE decision making. DOE's new NEPA regulations were published on April 24, 1992 and required greater state and Native American involvement in the preparation of EAs. Delegation of EA authority to the DOE field offices followed the current Secretary of Energy's letter of June 13, 1994. In order for delegation to take place each DOE field element provided a plan that included internal scoping and public participation in the EA process. Since the Manhattan Project the Hanford Site has been a crucial component of the nation's nuclear weapons program. Since the late 1980s Hanford's mission has changed from the production of defense nuclear materials to environmental clean-up. This paper will provide an overview of NEPA at the Hanford Site since 1990 and how the application of NEPA has changed in the five years since SEN-15. Of particular interest will be the EA process at Hanford. This EA process strongly parallels the procedural requirements for an EIS. It includes notification of states, Native Americans, and the public, internal scoping, preparation and circulation of a draft EA, and creation of a panel for making recommendations regarding the significance of the proposed action

  10. Accumulation of Cd in Indian mustard and sunflower for phytoremediation

    International Nuclear Information System (INIS)

    Okada, Satoshi; Fukutani, Satoshi; Takahashi, Tomoyuki; Fukui, Masami

    2004-01-01

    Phytoremediation is a new method that uses plants to remove contaminants from soil without affecting soil fertility. It can therefore be used for contaminated agricultural land. Indian mustard (Brassica juncea) and sunflower (Helianthus annuus L.) are used in phytoremediation to remove Cadmium (Cd), which they can accumulate in large quantities. It is important to know when plants have accumulated significant Cd, so that we can decide when the plants should be harvested and synthetic chelates applied. Brassica juncea seeds and Helianthus annuus L. seeds were planted in a field in Kyoto University Research Reactor Institute (KUR). Brassica juncea and Helianthus annuus L. were collected at time intervals ranging from 1 to 6 months and 2 to 7 weeks, respectively, after seedling emergence and the concentration of Cd in the plants was analyzed. These results indicated that Brassica juncea should be harvested before beginning flowering and Helianthus annuus L. should be harvested after it becomes old enough. The solubility of Cd in soil is enhanced when the soil is heated or dried, and black vinyl mulch was therefore used to absorb the heat from sunlight. The difference in the Cd uptake of Brassica juncea between mulching cultivation and non-mulching cultivation was investigated in a field, and this indicated that there is no probability that mulching enhances Cd uptake in plants. The solubility of Cd in soil decreases over time. Repeated pot experiments were done. We planted Brassica juncea in pots, and investigated the uptake of Cd and the solid phase fractions in which Cd was present in each pot experiment. These did not change considerably over time, indicating that age has a negligible effect on Cd uptake in plants. (author)

  11. CD-ROM-aided Databases

    Science.gov (United States)

    Kusama, Hideo; Matsumoto, Toshiaki

    The CD-ROM system can be used independently or as a compliment to an on-line data system. It has many of the same features as an on-line system. Nippan developed the CD-NOCS system as a reinforcement or substitute for the on-line systems of the customers (bookstores). CD-NOCS is not necessarily designed just for bookstores, it is also applicable to libraries and companies. Authors would also like to emphasize that it is important to understand the development and background of the CD-NOCS system, as well as its operations.

  12. Influence of NaCl-Induced Salinity and Cd Toxicity on Respiration Activity and Cd Availability to Barley Plants in Farmyard Manure-Amended Soil

    Directory of Open Access Journals (Sweden)

    Adel R. A. Usman

    2015-01-01

    Full Text Available The objective of this study was to evaluate the Cd availability and toxicity as affected by NaCl-induced salinity and farmyard manure addition. The Cd availability and toxicity were investigated in greenhouse pot and incubation experiments were conducted on a calcareous loamy sand soil contaminated with Cd (0.5, 1.5, 3, 6, 12, and 24 mg kg−1 of soil and amended with two rates of 0.0 and 30 g farmyard manure (FYM kg−1. Barley seeds (Hordeum vulgare L. were sown in pots and irrigated with water containing different levels of salinity (0, 30, 60, and 120 mM NaCl. The results revealed that the DTPA-extractable Cd and its content in barley plant shoots tended to increase in line as Cd was applied and salt levels increased. Elevated decreases in the soil basal respiration with increased Cd applied and NaCl-induced salinity were found. However, applying FYM significantly reduced Cd availability and increased plant growth and soil respiration activity. The results clearly showed that adding farmyard manure as soil organic amendment decreased the availability of Cd to barley plants and mitigated the toxicity of both Cd and salinity to soil microbial activity.

  13. ACVP-03: Novel CD4+ T Cell Specific Immunohistochemistry Detection and Analysis Utilizing Masking of Not-T Cell CD4 in Fixed Tissues from Virally Infected and Uninfected Specimens | Frederick National Laboratory for Cancer Research

    Science.gov (United States)

    The Tissue Analysis Core (TAC) within the AIDS and Cancer Virus Program will process, embed, and perform microtomy on fixed tissue samples presented in ethanol. CD4 (DAB) and CD68/CD163 (FastRed) double immunohistochemistry will be performed, in whic

  14. Cd Mobility in Anoxic Fe-Mineral-Rich Environments - Potential Use of Fe(III)-Reducing Bacteria in Soil Remediation

    Science.gov (United States)

    Muehe, E. M.; Adaktylou, I. J.; Obst, M.; Schröder, C.; Behrens, S.; Hitchcock, A. P.; Tylsizczak, T.; Michel, F. M.; Krämer, U.; Kappler, A.

    2014-12-01

    Agricultural soils are increasingly burdened with heavy metals such as Cd from industrial sources and impure fertilizers. Metal contaminants enter the food chain via plant uptake from soil and negatively affect human and environmental health. New remediation approaches are needed to lower soil metal contents. To apply these remediation techniques successfully, it is necessary to understand how soil microbes and minerals interact with toxic metals. Here we show that microbial Fe(III) reduction initially mobilizes Cd before its immobilization under anoxic conditions. To study how microbial Fe(III) reduction influences Cd mobility, we isolated a new Cd-tolerant, Fe(III)-reducing Geobacter sp. from a heavily Cd-contaminated soil. In lab experiments, this Geobacter strain first mobilized Cd from Cd-loaded Fe(III) hydroxides followed by precipitation of Cd-bearing mineral phases. Using Mössbauer spectroscopy and scanning electron microscopy, the original and newly formed Cd-containing Fe(II) and Fe(III) mineral phases, including Cd-Fe-carbonates, Fe-phosphates and Fe-(oxyhydr)oxides, were identified and characterized. Using energy-dispersive X-ray spectroscopy and synchrotron-based scanning transmission X-ray microscopy, Cd was mapped in the Fe(II) mineral aggregates formed during microbial Fe(III) reduction. Microbial Fe(III) reduction mobilizes Cd prior to its precipitation in Cd-bearing mineral phases. The mobilized Cd could be taken up by phytoremediating plants, resulting in a net removal of Cd from contaminated sites. Alternatively, Cd precipitation could reduce Cd bioavailability in the environment, causing less toxic effects to crops and soil microbiota. However, the stability and thus bioavailability of these newly formed Fe-Cd mineral phases needs to be assessed thoroughly. Whether phytoremediation or immobilization of Cd in a mineral with reduced Cd bioavailability are feasible mechanisms to reduce toxic effects of Cd in the environment remains to be

  15. [Effect of different organic fertilizers on bioavailability of soil Cd and Zn].

    Science.gov (United States)

    Xie, Yun-he; Ji, Xiong-hui; Wu, Jia-mei; Huang, Juan; Guan, Di; Zhu, Jian

    2015-03-01

    The active effect of soil Cd and Zn and their interaction was studied in typical paddy field in south China by monitoring the contents of Cd and Zn in soil and rice in rice fields applied with pig manure, chicken manure or rice straw for 4 years continuously. The results showed that applying pig manure, chicken manure or rice straw had no significant impact on the soil total Cd content, soil available Cd content and soil Cd activity, but tended to increase the soil total Cd content and increased the soil total Zn content, soil available Zn content and Zn activity significantly. Applications of pig manure, chicken manure and rice straw all reduced the Cd content of brown rice, in order of pig manure > chicken manure > rice straw. The Cd contents of brown rice, stem and leaf in the treatment applied with pig manure were lower than in the control by 37.5%, 44.0% and 36.4%, respectively; the Cd contents of brown rice, stem and leaf in the treatment applied with chicken manure were lower than in the control by 22.5%, 33.8%, and 22.7%, respectively; the Cd content of brown rice in the treatment applied with rice straw was lower than in the control by 7.5% but its contents in stem and leaf increased by 8.2% and 22.7% , respectively. The reduction in the brown rice Cd content was mainly due to the reduction of Cd enrichment from soil to brown rice after application of pig or chicken manure, but mainly due to the reduction of Cd transportation from stem to brown rice after straw application. Applications of pig manure, chicken manure and rice straw increased Zn contents in rice stem by 53.4%, 53.4% and 13.9%, respectively, but all had no significant effect on brown rice and leaf' s Zn contents. Zn and Cd had the significant antagonistic effects in the soil and rice stem. The increase of Zn content in soil and rice stem inhibited the adsorption and accumulation of Cd in the brown rice, stem and leaf significantly, and with the increase of the proportion of Zn/Cd, the

  16. CD4+CD25+ T regulatory cells from FIV+ cats induce a unique anergic profile in CD8+ lymphocyte targets

    Directory of Open Access Journals (Sweden)

    Tompkins Mary B

    2010-11-01

    Full Text Available Abstract Background Using the FIV model, we reported previously that CD4+CD25+ T regulatory (Treg cells from FIV+ cats are constitutively activated and suppress CD4+CD25- and CD8+ T cell immune responses. In an effort to further explore Treg-mediated suppression, we asked whether Treg cells induce anergy through the alteration of production of cyclins, cyclin-dependent kinases and their inhibitors. Results Lymphocytes were obtained from control or FIV+ cats and sorted by FACS into CD4+CD25+ and CD8+ populations. Following co-culture with CD4+CD25+ cells, CD8+ targets were examined by Western blot for changes in cyclins D3, E and A, retinoblastoma (Rb protein, as well as the cyclin dependent kinase inhibitor p21cip1. Following co-culture with CD4+CD25+cells, we observed up-regulation of p21cip1 and cyclin E, with down-regulation of cyclin D3, in CD8+ cells from FIV+ cats. As expected, CD8+ targets from control cats were quiescent with little up-regulation of p21cip1 and cyclin E. There was also a lack of Rb phosphorylation in CD8+ targets consistent with late G1 cell cycle arrest. Further, IL-2 mRNA was down regulated in CD8+ cells after co-culture with CD4+CD25+ Treg cells. Following CD4+CD25+ co-culture, CD8+ targets from FIV+ cats also had increased Foxp3 mRNA expression; however, these CD8+Foxp3+ cells did not exhibit suppressor function. Conclusions Collectively, these data suggest that CD4+CD25+ Treg cells from FIV+ cats induce CD8+ anergy by disruption of normal G1 to S cell cycle progression.

  17. Effect of magnetic field on the donor impurity in CdTe/Cd1-xMnxTe quantum well wire

    Science.gov (United States)

    Kalpana, P.; Reuben, A. Merwyn Jasper D.; Nithiananthi, P.; Jayakumar, K.

    2016-05-01

    The donor impurity binding energy in CdTe / Cd1-xMnxTe QWW with square well confinement along x - direction and parabolic confinement along y - direction under the influence of externally applied magnetic field has been computed using variational principle in the effective mass approximation. The spin polaronic shift has also been computed. The results are presented and discussed.

  18. The quadrupole moments of Cd and Zn isotopes - an apology

    Science.gov (United States)

    Haas, H.; Barbosa, M. B.; Correia, J. G.

    2016-12-01

    In 2010 we presented an update of the nuclear quadrupole moments (Q) for the Cd and Zn isotopes, based essentially on straightforward density functional (DF) calculations (H. Haas and J.G. Correia, Hyperfine Interact 198, 133-137 (2010)). It has been apparent for some years that the standard DF procedure obviously fails, however, to reproduce the known electric-field gradient (EFG) for various systems, typical cases being Cu2O, As and Sb, and the solid halogens. Recently a cure for this deficiency has been found in the hybrid DF technique. This method is now applied to solid Cd and Zn, and the resultant quadrupole moments are about 15 % smaller than in our earlier report. Also nuclear systematics, using the recently revised values of Q for the long-lived 11/2 isomers in111Cd to129Cd, together with earlier PAD data for107,109Cd, leads to the same conclusion. In addition, EFG calculations for the cadmium dimethyl molecule further support the new values: Q(111Cd, 5/2+) = .683(20) b, Q(67Zn, gs) = .132(5) b. This implies, that the value for the atomic EFG in the 3it {P}1 state of Zn must be revised, as it has been for Cd.

  19. Review of World of Money CD-ROM for PC/Mac [CD-ROM

    Directory of Open Access Journals (Sweden)

    Philip de Jersey

    1998-12-01

    Full Text Available Following on from the impressive development of the new HSBC Money Gallery in 1997, the British Museum has launched into the world of electronic publishing with the World of Money, an "interactive exploration of money worldwide from ancient times to the present day". Intended for ages ten to adult, the CD promises "a mine of information about the use, form, history and importance of money around the globe", and "fun and information for all the family". Reviewing in a Mac-unfriendly environment, I have been able to run the CD only on a PC. On a 166Mhz MMX with 32Mb RAM and a 12x CD it runs impressively quickly, with no more than two or three seconds of the "loading new page" display when switching between different parts of the program. Minimum requirements are listed as a 486 with 8Mb RAM, 40Mb free hard disk space, Windows 3.11 or Windows 95, 4x CD drive, 1Mb 256 colours graphics card, 16-bit Sound Blaster compatible sound card, and a VGA monitor. Minimum requirements for the Mac are listed as System 7, 603e processor, 16Mb RAM, 40MB free hard disk space, 6x CD drive, 1Mb video card and Apple monitor or Multisync with adaptor. The CD opens with an image of the British Museum portico, through which we are taken into the foyer, complete with the sound effects of massed ranks of tourists. We have four options available on a lectern, or by turning left, right or going upstairs: History of Money, Information Centre, Activities, and Options. Clicking on a large question mark brings up the Help screens (Figure 1.

  20. CD4(+)/CD8(+) T-lymphocyte Ratio: Effects of Rehydration before Exercise in Dehydrated Men

    Science.gov (United States)

    Greenleaf, John E.; Jackson, Catherine G. R.; Lawless, Desales

    1995-01-01

    Effects of fluid ingestion on CD4+/CD8+ T-lymphocyte cell ratios were measured in four dehydrated men (ages 30-46 yr) before and after 70 min of supine submaximal (71 % VO(sub 2max) lower extremity cycle exercise. Just before exercise, Evans blue dye was injected for measurement of plasma volume. The subjects then drank one of six fluid formulations (12 ml/kg) in 3-4 min. All six mean post-hydration (pre-exercise) CD4+/CD8+ ratios (Becton-Dickinson Fluorescence Activated Cell Sorter and FACScan Consort-30 software program were below the normal range of 1.2-1.5; mean (+/- SE) and range were 0.77 +/- 0.12 and 0.39-1.15, respectively. The post-exercise ratios increased: mean = 1.36 =/- 0.15 (P less than 0.05) and range = 0.98-1.98. Regression of mean CD4+/CD8+ ratios on mean plasma osmolality resulted in pre- and post-exercise correlation coefficients of -0.76 (P less than 0.10) and -0.92 (P less than 0.01), respectively. The decreased pre-exercise ratios (after drinking) were probably not caused by the Evans blue dye but appeared to be associated more with the stress (osmotic) of dehydration. The increased post-exercise ratios to normal levels accompanied the rehydration and were not due to the varied electrolyte and osmotic concentrations of the ingested fluids or to the varied vascular volume shifts during exercise. Thus, the level of subject hydration and plasma osmotality may be factors involved in the mechanism of immune system modulation induced by exercise.

  1. APPLIED ORGANIZATION OF CONSTRUCTION

    Directory of Open Access Journals (Sweden)

    Kievskiy Leonid Vladimirovich

    2017-03-01

    Full Text Available Applied disciplines in the sphere of construction which are engaged in the solution of vital macroeconomical problems (the general trend of development of these disciplines is the expansion of problematics and mutual integration are considered. Construction organization characteristic at the present stage as a systems engineering discipline covering the investment process of creation of real estate items, is given. The main source of current research trends for applied sciences (socio-economic development forecasts, regional and local programs is determined. Interpenetration and integration of various fields of knowledge exemplified by the current interindustry problem of blocks renovation organization of existing development, is demonstrated. Mathematical model of wave construction (for the period of deployment is proposed. Nature of dependence of the total duration of renovation on the limit of annual input and coefficient of renovation, is established. Overall structure of the Moscow region housing market is presented, and approaches to definition of effective demand are proposed.

  2. Control of Memory CD8+ T Cell Differentiation by CD80/CD86-CD28 Costimulation and Restoration by IL-2 during the Recall Response1

    OpenAIRE

    Fuse, Shinichiro; Zhang, Weijun; Usherwood, Edward J.

    2008-01-01

    Memory CD8+ T cell responses have been considered to be independent of CD80/CD86-CD28 costimulation. However, recall responses are often severely blunted in CD28−/− mice. Whether this impairment represents a requirement for CD28 costimulation for proper memory CD8+ T cell development or a requirement during the recall response is unknown. Furthermore, how CD28 costimulation affects the phenotype and function of memory CD8+ T cells has not been characterized in detail. In this study, we invest...

  3. Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection.

    Directory of Open Access Journals (Sweden)

    Michael Schindler

    2008-07-01

    Full Text Available Recent data suggest that Nef-mediated downmodulation of TCR-CD3 may protect SIVsmm-infected sooty mangabeys (SMs against the loss of CD4+ T cells. However, the mechanisms underlying this protective effect remain unclear. To further assess the role of Nef in nonpathogenic SIV infection, we cloned nef alleles from 11 SIVsmm-infected SMs with high (>500 and 15 animals with low (<500 CD4+ T-cells/microl in bulk into proviral HIV-1 IRES/eGFP constructs and analyzed their effects on the phenotype, activation, and apoptosis of primary T cells. We found that not only efficient Nef-mediated downmodulation of TCR-CD3 but also of MHC-I correlated with preserved CD4+ T cell counts, as well as with high numbers of Ki67+CD4+ and CD8+CD28+ T cells and reduced CD95 expression by CD4+ T cells. Moreover, effective MHC-I downregulation correlated with low proportions of effector and high percentages of naïve and memory CD8+ T cells. We found that T cells infected with viruses expressing Nef alleles from the CD4low SM group expressed significantly higher levels of the CD69, interleukin (IL-2 and programmed death (PD-1 receptors than those expressing Nefs from the CD4high group. SIVsmm Nef alleles that were less active in downmodulating TCR-CD3 were also less potent in suppressing the activation of virally infected T cells and subsequent cell death. However, only nef alleles from a single animal with very low CD4+ T cell counts rendered T cells hyper-responsive to activation, similar to those of HIV-1. Our data suggest that Nef may protect the natural hosts of SIV against the loss of CD4+ T cells by at least two mechanisms: (i downmodulation of TCR-CD3 to prevent activation-induced cell death and to suppress the induction of PD-1 that may impair T cell function and survival, and (ii downmodulation of MHC-I to reduce CTL lysis of virally infected CD4+ T cells and/or bystander CD8+ T cell activation.

  4. HuMax-CD4

    DEFF Research Database (Denmark)

    Skov, Lone; Kragballe, Knud; Zachariae, Claus

    2003-01-01

    BACKGROUND: Psoriasis is characterized by infiltration with mononuclear cells. Especially activated memory CD4+ T cells are critical in the pathogenesis. Interaction between the CD4 receptor and the major histocompatibility complex class II molecule is important for T-cell activation. OBJECTIVE......: To test safety and efficacy of a fully human monoclonal anti-CD4 antibody (HuMax-CD4) in the treatment of psoriasis. DESIGN: Multicenter, double-blind, placebo-controlled, randomized clinical trial. Patients Eighty-five patients with moderate to severe psoriasis. INTERVENTIONS: Subcutaneous infusions...... dose level, 6 (38%) of 16 patients obtained more than 25% reduction of PASI and 3 (19%) obtained more than 50% reduction of PASI. A dose-dependent decrease in total lymphocyte count was seen and was parallel to a dose-dependent decrease in CD4+ T cells. This decrease was due to a decrease in the memory...

  5. Remediation of Cd-contaminated soil around metal sulfide mines

    Science.gov (United States)

    Lu, Xinzhe; Hu, Xuefeng; Kang, Zhanjun; Luo, Fan

    2017-04-01

    the key to the remediation of Cd-contaminated soils, and apply the composite material of zeolite combining apatite is the best choice for the remediation of Cd-contaminated soils.

  6. Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion.

    Directory of Open Access Journals (Sweden)

    Zuopeng Wu

    2016-05-01

    Full Text Available Most humans harbor both CD177neg and CD177pos neutrophils but 1-10% of people are CD177null, placing them at risk for formation of anti-neutrophil antibodies that can cause transfusion-related acute lung injury and neonatal alloimmune neutropenia. By deep sequencing the CD177 locus, we catalogued CD177 single nucleotide variants and identified a novel stop codon in CD177null individuals arising from a single base substitution in exon 7. This is not a mutation in CD177 itself, rather the CD177null phenotype arises when exon 7 of CD177 is supplied entirely by the CD177 pseudogene (CD177P1, which appears to have resulted from allelic gene conversion. In CD177 expressing individuals the CD177 locus contains both CD177P1 and CD177 sequences. The proportion of CD177hi neutrophils in the blood is a heritable trait. Abundance of CD177hi neutrophils correlates with homozygosity for CD177 reference allele, while heterozygosity for ectopic CD177P1 gene conversion correlates with increased CD177neg neutrophils, in which both CD177P1 partially incorporated allele and paired intact CD177 allele are transcribed. Human neutrophil heterogeneity for CD177 expression arises by ectopic allelic conversion. Resolution of the genetic basis of CD177null phenotype identifies a method for screening for individuals at risk of CD177 isoimmunisation.

  7. Study of CdTe/CdS solar cell at low power density for low-illumination applications

    Energy Technology Data Exchange (ETDEWEB)

    Devi, Nisha, E-mail: nishatanwer1989@gmail.com; Aziz, Anver, E-mail: aaziz@jmi.ac.in [Department Of Physics, Solar PV Lab, Jamia Millia Islamia, New Delhi-110025 (India); Datta, Shouvik [Department of Physics, IISER-Pune, Dr.homi Bhabha road, Pashan, Pune-411008 (India)

    2016-05-06

    In this paper, we numerically investigate CdTe/CdS PV cell properties using a simulation program Solar Cell Capacitance Simulator in 1D (SCAPS-1D). A simple structure of CdTe PV cell has been optimized to study the effect of temperature, absorber thickness and work function at very low incident power. Objective of this research paper is to build an efficient and cost effective solar cell for portable electronic devices such as portable computers and cell phones that work at low incident power because most of such devices work at diffused and reflected sunlight. In this report, we simulated a simple CdTe PV cell at very low incident power, which gives good efficiency.

  8. Study of CdTe/CdS solar cell at low power density for low-illumination applications

    International Nuclear Information System (INIS)

    Devi, Nisha; Aziz, Anver; Datta, Shouvik

    2016-01-01

    In this paper, we numerically investigate CdTe/CdS PV cell properties using a simulation program Solar Cell Capacitance Simulator in 1D (SCAPS-1D). A simple structure of CdTe PV cell has been optimized to study the effect of temperature, absorber thickness and work function at very low incident power. Objective of this research paper is to build an efficient and cost effective solar cell for portable electronic devices such as portable computers and cell phones that work at low incident power because most of such devices work at diffused and reflected sunlight. In this report, we simulated a simple CdTe PV cell at very low incident power, which gives good efficiency.

  9. Detoxification and sensing mechanisms are of similar importance for Cd resistance in Caenorhabditis elegans

    Directory of Open Access Journals (Sweden)

    Sarah A. Winter

    2016-10-01

    Full Text Available The present study employed mass spectrometry (ICP-MS to measure the internal cadmium concentrations (Cdint in Caenorhabditis elegans to determine Cd uptake from a Cd-containing environment as well as Cd release under Cd-free conditions. To analyze the functional role of several ATP binding cassette (ABC transporters (e.g., HMT-1 and MRP-1 and phytochelatin synthase (PCS, we compared wild-type (WT and different mutant strains of C. elegans. As a pre-test on selected mutant strains, several time-resolved experiments were performed to determine the survival rate and avoidance behavior of C. elegans under Cd stress, which confirmed the already known Cd sensitivity of the deletion mutants mrp-1Δ, pcs-1Δ, and hmt-1Δ. In addition, these experiments revealed flight reactions under Cd stress to be almost completely absent in mrp-1Δ mutants. The ICP-MS studies showed Cd uptake to be significantly higher in mrp-1Δ and WT than in hmt-1Δ. As Cd is ingested with food, food refusal due to very early Cd stress and its perception was likely the reason for the reduced Cd uptake of hmt-1Δ. Cd release (detoxification was found to be maximal in mrp-1Δ, minimal in hmt-1Δ, and intermediate in WT. High mortality under Cd stress, food refusal, and minimal Cd release in the case of hmt-1Δ suggest a vital importance of the HMT-1/PCS-1 detoxification system for the survival of C. elegans under Cd stress. High mortality under Cd stress, absence of an avoidance behavior, missing food refusal, and maximal Cd release in the case of mrp-1Δ indicate that MRP-1 is less important for Cd detoxification under severe stress, but is probably important for Cd perception. Accordingly, our results suggest that the survival of WT under Cd stress (or possibly other forms of metal stress primarily depends on the function of the HMT-1/PCS-1 detoxification system and the presence of a sensing mechanism to control the uptake of Cd (or other metals, which keeps internal Cd (or metal

  10. Applying the COM-B model to creation of an IT-enabled health coaching and resource linkage program for low-income Latina moms with recent gestational diabetes: the STAR MAMA program.

    Science.gov (United States)

    Handley, Margaret A; Harleman, Elizabeth; Gonzalez-Mendez, Enrique; Stotland, Naomi E; Althavale, Priyanka; Fisher, Lawrence; Martinez, Diana; Ko, Jocelyn; Sausjord, Isabel; Rios, Christina

    2016-05-18

    One of the fastest growing risk groups for early onset of diabetes is women with a recent pregnancy complicated by gestational diabetes, and for this group, Latinas are the largest at-risk group in the USA. Although evidence-based interventions, such as the Diabetes Prevention Program (DPP), which focuses on low-cost changes in eating, physical activity and weight management can lower diabetes risk and delay onset, these programs have yet to be tailored to postpartum Latina women. This study aims to tailor a IT-enabled health communication program to promote DPP-concordant behavior change among postpartum Latina women with recent gestational diabetes. The COM-B model (incorporating Capability, Opportunity, and Motivational behavioral barriers and enablers) and the Behavior Change Wheel (BCW) framework, convey a theoretically based approach for intervention development. We combined a health literacy-tailored health IT tool for reaching ethnic minority patients with diabetes with a BCW-based approach to develop a health coaching intervention targeted to postpartum Latina women with recent gestational diabetes. Current evidence, four focus groups (n = 22 participants), and input from a Regional Consortium of health care providers, diabetes experts, and health literacy practitioners informed the intervention development. Thematic analysis of focus group data used the COM-B model to determine content. Relevant cultural, theoretical, and technological components that underpin the design and development of the intervention were selected using the BCW framework. STAR MAMA delivers DPP content in Spanish and English using health communication strategies to: (1) validate the emotions and experiences postpartum women struggle with; (2) encourage integration of prevention strategies into family life through mothers becoming intergenerational custodians of health; and (3) increase social and material supports through referral to social networks, health coaches, and

  11. Pixelated CdZnTe drift detectors

    DEFF Research Database (Denmark)

    Kuvvetli, Irfan; Budtz-Jørgensen, Carl

    2005-01-01

    A technique, the so-called Drift Strip Method (DSM), for improving the CdZnTe detector energy response to hard X-rays and gamma-rays was applied as a pixel geometry. First tests have confirmed that this detector type provides excellent energy resolution and imaging performance. We specifically...... report on the performance of 3 mm thick prototype CZT drift pixel detectors fabricated using material from eV-products. We discuss issues associated with detector module performance. Characterization results obtained from several prototype drift pixel detectors are presented. Results of position...

  12. CD3+, CD56+, CD4−, CD8−, CD20−, CD30− Peripheral T-Cell Non-Hodgkin's Lymphoma: A Rare Case Report

    Directory of Open Access Journals (Sweden)

    Ashish Jagati

    2017-01-01

    Full Text Available Cutaneous T-cell lymphoma (CTCL commonly presents as mycosis fungoides or Sezary syndrome, both having CD4 positivity. A subset of CTCL which lacks CD4 surface marker is classified as cutaneous g and d–T-cell lymphoma (CGD-TCL. Because of its rarity and inability to study large number of patients, the impact of immunophenotype on the clinical outcome of primary CTCL in patients is limited. We report a case of primary CGD-TCL in a 71-year-old male because of this rarity and to emphasize its aggressive nature.

  13. Charge separation and transfer in hybrid type II tunneling structures of CdTe and CdSe nanocrystals

    International Nuclear Information System (INIS)

    Gross, Dieter Konrad Michael

    2013-01-01

    Closely packed nanocrystal systems have been investigated in this thesis with respect to charge separation by charge carrier tunneling. Clustered and layered samples have been analyzed using PL-measurements and SPV-methods. The most important findings are reviewed in the following. A short outlook is also provided for potential further aspects and application of the presented results. The main purpose of this thesis was to find and quantify electronic tunneling transfer in closely packed self-assembled nanocrystal structures presenting quantum mechanical barriers of about 1 nm width. We successfully used hybrid assemblies of CdTe and CdSe nanocrystals where the expected type II alignment between CdTe and CdSe typically leads to a concentration of electrons in CdSe and holes in CdTe nanocrystals. We were able to prove the charge selectivity of the CdTe-CdSe nanocrystal interface which induces charge separation. We mainly investigated the effects related to the electron transfer from CdTe to CdSe nanocrystals. Closely packing was achieved by two independent methods: the disordered colloidal clustering in solution and the layered assembly on dry glass substrates. Both methods lead to an inter-particle distance of about 1 nm of mainly organic material which acts as a tunneling barrier. PL-spectroscopy was applied. The PL-quenching of the CdTe nanocrystals in hybrid assemblies indicates charge separation by electron transfer from CdTe to CdSe nanocrystals. A maximum quenching rate of up to 1/100 ps was measured leading to a significant global PL-quenching of up to about 70 % for the CdTe nanocrystals. It was shown that charge separation dynamics compete with energy transfer dynamics and that charge separation typically dominates. The quantum confinement effect was used to tune the energetic offset between the CdTe and CdSe nanocrystals. We thus observe a correlation of PL-quenching and offset of the energy states for the electron transfer. The investigated PL

  14. Charge separation and transfer in hybrid type II tunneling structures of CdTe and CdSe nanocrystals

    Energy Technology Data Exchange (ETDEWEB)

    Gross, Dieter Konrad Michael

    2013-11-08

    Closely packed nanocrystal systems have been investigated in this thesis with respect to charge separation by charge carrier tunneling. Clustered and layered samples have been analyzed using PL-measurements and SPV-methods. The most important findings are reviewed in the following. A short outlook is also provided for potential further aspects and application of the presented results. The main purpose of this thesis was to find and quantify electronic tunneling transfer in closely packed self-assembled nanocrystal structures presenting quantum mechanical barriers of about 1 nm width. We successfully used hybrid assemblies of CdTe and CdSe nanocrystals where the expected type II alignment between CdTe and CdSe typically leads to a concentration of electrons in CdSe and holes in CdTe nanocrystals. We were able to prove the charge selectivity of the CdTe-CdSe nanocrystal interface which induces charge separation. We mainly investigated the effects related to the electron transfer from CdTe to CdSe nanocrystals. Closely packing was achieved by two independent methods: the disordered colloidal clustering in solution and the layered assembly on dry glass substrates. Both methods lead to an inter-particle distance of about 1 nm of mainly organic material which acts as a tunneling barrier. PL-spectroscopy was applied. The PL-quenching of the CdTe nanocrystals in hybrid assemblies indicates charge separation by electron transfer from CdTe to CdSe nanocrystals. A maximum quenching rate of up to 1/100 ps was measured leading to a significant global PL-quenching of up to about 70 % for the CdTe nanocrystals. It was shown that charge separation dynamics compete with energy transfer dynamics and that charge separation typically dominates. The quantum confinement effect was used to tune the energetic offset between the CdTe and CdSe nanocrystals. We thus observe a correlation of PL-quenching and offset of the energy states for the electron transfer. The investigated PL

  15. Charge separation and transfer in hybrid type II tunneling structures of CdTe and CdSe nanocrystals

    Energy Technology Data Exchange (ETDEWEB)

    Gross, Dieter Konrad Michael

    2013-11-08

    Closely packed nanocrystal systems have been investigated in this thesis with respect to charge separation by charge carrier tunneling. Clustered and layered samples have been analyzed using PL-measurements and SPV-methods. The most important findings are reviewed in the following. A short outlook is also provided for potential further aspects and application of the presented results. The main purpose of this thesis was to find and quantify electronic tunneling transfer in closely packed self-assembled nanocrystal structures presenting quantum mechanical barriers of about 1 nm width. We successfully used hybrid assemblies of CdTe and CdSe nanocrystals where the expected type II alignment between CdTe and CdSe typically leads to a concentration of electrons in CdSe and holes in CdTe nanocrystals. We were able to prove the charge selectivity of the CdTe-CdSe nanocrystal interface which induces charge separation. We mainly investigated the effects related to the electron transfer from CdTe to CdSe nanocrystals. Closely packing was achieved by two independent methods: the disordered colloidal clustering in solution and the layered assembly on dry glass substrates. Both methods lead to an inter-particle distance of about 1 nm of mainly organic material which acts as a tunneling barrier. PL-spectroscopy was applied. The PL-quenching of the CdTe nanocrystals in hybrid assemblies indicates charge separation by electron transfer from CdTe to CdSe nanocrystals. A maximum quenching rate of up to 1/100 ps was measured leading to a significant global PL-quenching of up to about 70 % for the CdTe nanocrystals. It was shown that charge separation dynamics compete with energy transfer dynamics and that charge separation typically dominates. The quantum confinement effect was used to tune the energetic offset between the CdTe and CdSe nanocrystals. We thus observe a correlation of PL-quenching and offset of the energy states for the electron transfer. The investigated PL

  16. Differential number of CD34+, CD133+ and CD34+/CD133+ cells in peripheral blood of patients with congestive heart failure

    Directory of Open Access Journals (Sweden)

    Fritzenwanger M

    2009-03-01

    Full Text Available Abstract Background Endothelial progenitor cells (EPC which are characterised by the simulateous expression of CD34, CD133 and vascular endothelial growth receptor 2 (VEGF 2 are involved in the pathophysiology of congestive heart failure (CHF and their number and function is reduced in CHF. But so far our knowledge about the number of circulating hematopoietic stem/progenitor cells (CPC expressing the early hematopoietic marker CD133 and CD34 in CHF is spares and therefore we determined their number and correlated them with New York Heart Association (NYHA functional class. Methods CD34 and CD133 surface expression was quantified by flow cytometry in the peripheral venous blood of 41 healthy adults and 101 patients with various degrees of CHF. Results CD34+, CD133+ and CD34+/CD133+ cells correlated inversely with age. Both the number of CD34+ and of CD34+/CD133+ cells inversely correlated with NYHA functional class. The number of CD133+ cells was not affected by NYHA class. Furthermore the number of CD133+ cells did not differ between control and CHF patients. Conclusion In CHF the release of CD34+, CD133+ and CD34+/CD133+ cells from the bone marrow seems to be regulated differently. Modulating the releasing process in CHF may be a tool in CHF treatment.

  17. CdTe as a passivating layer in CdTe/HgCdTe heterostructures

    International Nuclear Information System (INIS)

    Virt, I. S.; Kurilo, I. V.; Rudyi, I. A.; Sizov, F. F.; Mikhailov, N. N.; Smirnov, R. N.

    2008-01-01

    CdTe/Hg 1-x Cd x Te heterostructures are studied. In the structures, CdTe is used as a passivating layer deposited as a polycrystal or single crystal on a single-crystal Hg 1-x Cd x Te film. The film and a passivating layer were obtained in a single technological process of molecular beam epitaxy. The structure of passivating layers was studied by reflection high-energy electron diffraction, and the effect of the structure of the passivating layer on the properties of the active layer was studied by X-ray diffractometry. Mechanical properties of heterostructures were studied by the microhardness method. Electrical and photoelectrical parameters of the Hg 1-x Cd x Te films are reported.

  18. Synthesis of CdTe/CdS/ZnS quantum dots and their application in imaging of hepatocellular carcinoma cells and immunoassay for alpha fetoprotein

    Energy Technology Data Exchange (ETDEWEB)

    Tian Jianniao; Liu Rongjun; Zhao Yanchun; Peng Yan; Hong Xue; Zhao Shulin [Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), College of Chemistry and Chemical Engineering of Guangxi Normal University, Guilin 541004 (China); Xu Qing, E-mail: tianjn58@yahoo.com.cn [Pharmacology Department of Guilin Medical College, Guilin 541004 (China)

    2010-07-30

    We report the imaging of hepatocellular carcinoma cells and the immunoassay for alpha fetoprotein (AFP) using CdTe/CdS/ZnS core-shell-shell QDs. Stable and high PLQY (20%-48%) CdTe/CdS/ZnS core-shell-shell QDs were synthesized by a stepwise process. Bioconjugation of the core-shell-shell QDs with streptavidin (SA) was successfully applied in immunofluorescent imaging of the human hepatocellular carcinoma (HCC) cell line HepG2.2.15. Furthermore, the thioglycolic acid (TGA)-capped CdTe/CdS/ZnS core-shell-shell QDs fluorescence lifetime is longer than fluorescein, so it was first engaged to conjugate with antigen for the determination of protein (AFP) by fluorescence polarization immunoassay.

  19. Synthesis of CdTe/CdS/ZnS quantum dots and their application in imaging of hepatocellular carcinoma cells and immunoassay for alpha fetoprotein

    International Nuclear Information System (INIS)

    Tian Jianniao; Liu Rongjun; Zhao Yanchun; Peng Yan; Hong Xue; Zhao Shulin; Xu Qing

    2010-01-01

    We report the imaging of hepatocellular carcinoma cells and the immunoassay for alpha fetoprotein (AFP) using CdTe/CdS/ZnS core-shell-shell QDs. Stable and high PLQY (20%-48%) CdTe/CdS/ZnS core-shell-shell QDs were synthesized by a stepwise process. Bioconjugation of the core-shell-shell QDs with streptavidin (SA) was successfully applied in immunofluorescent imaging of the human hepatocellular carcinoma (HCC) cell line HepG2.2.15. Furthermore, the thioglycolic acid (TGA)-capped CdTe/CdS/ZnS core-shell-shell QDs fluorescence lifetime is longer than fluorescein, so it was first engaged to conjugate with antigen for the determination of protein (AFP) by fluorescence polarization immunoassay.

  20. Influence of CdTe sub-monolayer stressor on CdSe quantum dot self-assembling in ZnSe

    International Nuclear Information System (INIS)

    Sedova, I.V.; Lyublinskaya, O.G.; Sorokin, S.V.; Sitnikova, A.A.; Solnyshkov, D.D.; Rykhova, O.V.; Toropov, A.A.; Ivanov, S.V.

    2006-01-01

    This paper reports on the attempt to apply the stressor-controlled quantum dot (QD) fabrication technique to the conventional CdSe/ZnSe nanostructures. Super-strained CdTe fractional monolayer (Δa/a∝14% for CdTe/ZnSe) grown on top of the Te-stabilized ZnSe surface prior to deposition of the QD material (CdSe) has been used as a stressor which is expected to affect size, composition and density of CdSe QDs. The grown structures are studied by X-ray diffraction, transmission-electron microscopy, photoluminescence (PL) and PL excitation in comparison with conventional CdSe/ZnSe QDs obtained by a modified migration enhanced epitaxy technique. (copyright 2006 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  1. Evaluation of CD4+/CD8+ status and urinary tract infections ...

    African Journals Online (AJOL)

    Evaluation of CD4+/CD8+ status and urinary tract infections associated with urinary schistosomiasis ... African Health Sciences ... by <50 ova /10ml of urine had a mean CD4+:CD8+ ratio of 1.57 while those with heavy infections as ... Key words: CD4+, CD8+, urinary tract infections, urinary schistosomiasis, rural Nigerians

  2. About | College of Engineering & Applied Science

    Science.gov (United States)

    ; Applied Science Powerful Ideas. Proven Results. Search for: Go This site All UWM Search Site Menu Skip to Degree Completion Program Graduate Programs Master of Science Programs Concentration in Biomedical Engineering Concentration on Ergonomics M.S. Program in Computer Science Interdisciplinary Concentration on

  3. Determination of normal expression patterns of CD86, CD210a, CD261, CD262, CD264, CD358, and CD361 in peripheral blood and bone marrow cells by flow cytometry.

    Science.gov (United States)

    Rudolf-Oliveira, Renata Cristina Messores; Auat, Mariangeles; Cardoso, Chandra Chiappin; Santos-Pirath, Iris Mattos; Lange, Barbara Gil; Pires-Silva, Jéssica; Moraes, Ana Carolina Rabello de; Dametto, Gisele Cristina; Pirolli, Mayara Marin; Colombo, Maria Daniela Holthausen Périco; Santos-Silva, Maria Claudia

    2018-02-01

    In 2010, new monoclonal antibodies were submitted to the 9th International Workshop on Human Leukocyte Differentiation Antigens, and there are few studies demonstrating normal expression patterns of these markers. Thus, the objective of this study was to determine the normal patterns of cell expression of CD86, CD210a, CD261, CD262, CD264, CD358, and CD361 in peripheral blood (PB) and bone marrow (BM) samples by flow cytometry. In the present study, CD86 was expressed only in monocytes and B lymphocytes in PB and in monocytes and plasma cells in BM. Regarding CD210a expression, in PB samples, monocytes and NK cells showed weak expression, while neutrophils, B and T lymphocytes, and basophils showed weak and partial expression. In BM samples, expression of CD210a was observed in eosinophils, monocytes, and B and T/NK lymphocytes. Weak expression of CD210a was also observed in neutrophilic cells and plasma cells. All B cell maturation stages had weak expression of CD210a except for immature B cells, which did not express this marker. In the present study, no cell type in PB samples showed positivity for CD261 and, in BM samples, there was very weak expression in neutrophilic series, monocytes, and B lymphocytes. Conversely, plasma cells showed positivity for CD261 with a homogeneous expression. For CD262, there was weak expression in monocytes, neutrophils, and B lymphocytes in PB samples and weak expression in monocytes, B lymphocytes, and plasma cells in BM samples. The evaluation of CD264 showed very weak expression in B cells in PB samples and no expression in BM cells. Very weak expression of CD358 was observed in neutrophils, monocytes, and B lymphocytes in PB and BM samples. In addition, in BM samples, plasma cells and T lymphocytes showed weak expression of CD358. In relation to the maturation stages of B cells, there was weak expression in pro-B cel, pre-B cell, and mature B cell. In the present study, it was possible to observe expression of CD361 in all

  4. CD-ROMs in Astronomy

    Science.gov (United States)

    Robertson, K.

    The CD-ROM has become a major data storage medium in astronomy. The release of the Digitized Sky Survey is the most recent example of this phenomena. I will summarize the large scale jukebox technologies available for making the DSS available over LANs (Local Area Networks). I will also give an overview of the developments in disciplines such as medicine, chemistry and business, where CD-ROMs have been used to distribute the full text of journals. These factors may give us insights into the future role of CD-ROMs.

  5. CD-ROM-aided Databases

    Science.gov (United States)

    Masuyama, Keiichi

    CD-ROM has rapidly evolved as a new information medium with large capacity, In the U.S. it is predicted that it will become two hundred billion yen market in three years, and thus CD-ROM is strategic target of database industry. Here in Japan the movement toward its commercialization has been active since this year. Shall CD-ROM bussiness ever conquer information market as an on-disk database or electronic publication? Referring to some cases of the applications in the U.S. the author views marketability and the future trend of this new optical disk medium.

  6. The reliability of cytoplasmic CD3 and CD22 antigen expression in the immunodiagnosis of acute leukemia: a study of 500 cases.

    Science.gov (United States)

    Janossy, G; Coustan-Smith, E; Campana, D

    1989-03-01

    Current views about the origin of acute lymphoid leukemia (ALL) emphasize the importance of maturation arrest at a precursor cell level. Recently, the CD22 antigen has been identified in the cytoplasm of normal bone marrow-borne immature B lineage cells, while the CD3 antigen (epsilon chain) has been detected within normal immature thymic blasts. In the first part our study performed on 100 cases of known acute leukemias, the expression of such cytoplasmic molecules, referred to as cCD22 and cCD3, was analyzed together with their appearance in the leukemic cells' membrane (mCD22 and mCD3). The presence of cCD22 in B-lineage ALL and that of cCD3 in T-ALL has indeed fully confirmed the diagnosis reached by other markers, and mCD22 and mCD3 were expressed on only a few cases of B- and T-lineage ALL, also revealing a degree of developmental asynchrony within leukemic blasts. In the subsequent analysis both cCD22 and cCD3 have been included in a standard panel of diagnostic reagents applied on 500 consecutive cases of acute leukemia. Here the aim was to analyze both the diagnostic precision of individual markers and the heterogeneity of various leukemic types in terms of the expression of membrane and intracellular antigens and their cytochemical features (Sudan Black B and esterases). It has been found that cCD22 and cCD3 are exquisitely specific for B-precursor ALL (TdT+, CD19+) and T-ALL (TdT+, CD7+), respectively, while both markers are absent in acute myeloblastic leukemia (AML) and acute myelomonocytic and monocytic leukemia (AMML/AMoL). These observations contrast the findings which demonstrate that 31% of cases among nonlymphoid acute leukemia (including AML and AMML) express CD7 and/or TdT. The study of myeloid antigens detected by CD13, CD33, and CD14 is also informative and complementary, both in diagnosing and subdividing the AML and AMML/AMoL groups. The peculiar main observation of this study is that only with the combined use of these markers in a

  7. Phenotyping and Target Expression Profiling of CD34+/CD38− and CD34+/CD38+ Stem- and Progenitor cells in Acute Lymphoblastic Leukemia

    Directory of Open Access Journals (Sweden)

    Katharina Blatt

    2018-06-01

    Full Text Available Leukemic stem cells (LSCs are an emerging target of curative anti-leukemia therapy. In acute lymphoblastic leukemia (ALL, LSCs frequently express CD34 and often lack CD38. However, little is known about markers and targets expressed in ALL LSCs. We have examined marker- and target expression profiles in CD34+/CD38− LSCs in patients with Ph+ ALL (n = 22 and Ph− ALL (n = 27 by multi-color flow cytometry and qPCR. ALL LSCs expressed CD19 (B4, CD44 (Pgp-1, CD123 (IL-3RA, and CD184 (CXCR4 in all patients tested. Moreover, in various subgroups of patients, LSCs also displayed CD20 (MS4A1 (10/41 = 24%, CD22 (12/20 = 60%, CD33 (Siglec-3 (20/48 = 42%, CD52 (CAMPATH-1 (17/40 = 43%, IL-1RAP (13/29 = 45%, and/or CD135 (FLT3 (4/20 = 20%. CD25 (IL-2RA and CD26 (DPPIV were expressed on LSCs in Ph+ ALL exhibiting BCR/ABL1p210, whereas in Ph+ ALL with BCR/ABL1p190, LSCs variably expressed CD25 but did not express CD26. In Ph− ALL, CD34+/CD38− LSCs expressed IL-1RAP in 6/18 patients (33%, but did not express CD25 or CD26. Normal stem cells stained negative for CD25, CD26 and IL-1RAP, and expressed only low amounts of CD52. In xenotransplantation experiments, CD34+/CD38− and CD34+/CD38+ cells engrafted NSG mice after 12–20 weeks, and targeting with antibodies against CD33 and CD52 resulted in reduced engraftment. Together, LSCs in Ph+ and Ph− ALL display unique marker- and target expression profiles. In Ph+ ALL with BCR/ABL1p210, the LSC-phenotype closely resembles the marker-profile of CD34+/CD38− LSCs in chronic myeloid leukemia, confirming the close biologic relationship of these neoplasms. Targeting of LSCs with specific antibodies or related immunotherapies may facilitate LSC eradication in ALL.

  8. Mouse CD23 regulates monocyte activation through an interaction with the adhesion molecule CD11b/CD18.

    Science.gov (United States)

    Lecoanet-Henchoz, S; Plater-Zyberk, C; Graber, P; Gretener, D; Aubry, J P; Conrad, D H; Bonnefoy, J Y

    1997-09-01

    CD23 is expressed on a variety of hemopoietic cells. Recently, we have reported that blocking CD23 interactions in a murine model of arthritis resulted in a marked improvement of disease severity. Here, we demonstrate that CD11b, the alpha chain of the beta 2 integrin adhesion molecule complex CD11b/CD18 expressed on monocytes interacts with CD23. Using a recombinant fusion protein (ZZ-CD23), murine CD23 was shown to bind to peritoneal macrophages and peripheral blood cells isolated from mice as well as the murine macrophage cell line, RAW. The interactions between mouse ZZ-CD23 and CD11b/CD18-expressing cells were significantly inhibited by anti-CD11b monoclonal antibodies. A functional consequence was then demonstrated by inducing an up-regulation of interleukin-6 (IL-6) production following ZZ-CD23 incubation with monocytes. The addition of Fab fragments generated from the monoclonal antibody CD11b impaired this cytokine production by 50%. Interestingly, a positive autocrine loop was identified as IL-6 was shown to increase CD23 binding to macrophages. These results demonstrate that similar to findings using human cells, murine CD23 binds to the surface adhesion molecule, CD11b, and these interactions regulate biological activities of murine myeloid cells.

  9. Reassignment of oxygen-related defects in CdTe and CdSe

    International Nuclear Information System (INIS)

    Bastin, Dirk

    2015-01-01

    This thesis reassigns the O_T_e-V_C_d complex in CdTe and the O_S_e-V_C_d complex in CdSe to a sulfur-dioxygen complex SO_2*, and the O_C_d defect in CdSe to a V_C_dH_2 complex using Fourier transformed infrared absorption spectroscopy. The publications of the previous complexes were investigated by theoreticians who performed first-principle calculations of theses complexes. The theoreticians ruled out the assignments and proposed alternative defects, instead. The discrepancy between the experimentally obtained and theoretically proposed defects was the motivation of this work. Two local vibrational modes located at 1096.8 (ν_1) and 1108.3 cm"-"1 (ν_2) previously assigned to an O_T_e-V_C_d complex are detected in CdTe single crystals doped with CdSO_4 powder. Five weaker additional absorption lines accompanying ν_1 and ν_2 could be detected. The relative intensities of the absorption lines match a sulfur-dioxygen complex SO_2* having two configurations labeled ν_1 and ν_2. A binding energy difference of 0.5±0.1 meV between the two configurations and an energy barrier of 53±4 meV separating the two configurations are determined. Uniaxial stress applied to the crystal leads to a splitting of the absorption lines which corresponds to an orthorhombic and monoclinic symmetry for ν_1 and ν_2, respectively. In virgin and oxygen-doped CdSe single crystals, three local vibrational modes located at 1094.1 (γ_1), 1107.5 (γ_2), and 1126.3 cm"-"1 (γ_3) previously attributed to an O_S_e-V_C_d complex could be observed. The signals are accompanied by five weaker additional absorption features in their vicinity. The additional absorption lines are identified as isotope satellites of a sulfur-dioxygen complex SO_2* having three configurations γ_1, γ_2, and γ_3. IR absorption measurements with uniaxial stress applied to the CdSe crystal yield a monoclinic C_1_h symmetry for γ_1 and γ_2. The SO_2* complex is stable up to 600 C. This thesis assigns the ν-lines in

  10. The Writing Process for "Edutaining" CD-ROM Adventures.

    Science.gov (United States)

    Mountain, Lee

    2000-01-01

    Describes a CD-ROM adventure story written by the author to educate her students about the word relationships of synonyms and antonyms. Discusses how this interactive medium put a different twist on each of the stages of the writing process itself. Relates how two students enthusiastically used the program, and were inspired to write one of their…

  11. [The expression and significance of CD(276) and CD(133) in colorectal cancer and precancerous lesions].

    Science.gov (United States)

    Lu, G F; Huang, L N; Ren, J L; Hu, G M; Zheng, Z H; Wu, J X; Zhu, Y P; Tang, F A

    2018-06-01

    In order to study the significance of CD(276) and CD(133) in the development and progression of colorectal cancer (CRC), the expression of CD(276) and CD(133) was detected by immunohistochemistry in CRC and precancerous lesions. The results showed that the intensity of CD(276) and CD(133) in CRC samples was higher than that in adenoma group and non-adenoma group. CD(276) and CD(133) single and double positive expression were significantly correlated with CRC lymph node metastasis, distant metastasis and survival. CD(276) and CD(133) are significantly correlated to the development and progression of CRC and associated with poor prognosis.

  12. Differential Effect of Cytomegalovirus Infection with Age on the Expression of CD57, CD300a, and CD161 on T-Cell Subpopulations

    Directory of Open Access Journals (Sweden)

    Fakhri Hassouneh

    2017-06-01

    Full Text Available Immunosenescence is a progressive deterioration of the immune system with aging. It affects both innate and adaptive immunity limiting the response to pathogens and to vaccines. As chronic cytomegalovirus (CMV infection is probably one of the major driving forces of immunosenescence, and its persistent infection results in functional and phenotypic changes to the T-cell repertoire, the aim of this study was to analyze the effect of CMV-seropositivity and aging on the expression of CD300a and CD161 inhibitory receptors, along with the expression of CD57 marker on CD4+, CD8+, CD8+CD56+ (NKT-Like and CD4−CD8− (DN T-cell subsets. Our results showed that, regardless of the T-cell subset, CD57−CD161−CD300a+ T-cells expand with age in CMV-seropositive individuals, whereas CD57−CD161+CD300a+ T-cells decrease. Similarly, CD57+CD161−CD300a+ T-cells expand with age in CMV-seropositive individuals in all subsets except in DN cells and CD57−CD161+CD300a− T-cells decrease in all T-cell subsets except in CD4+ T-cells. Besides, in young individuals, CMV latent infection associates with the expansion of CD57+CD161−CD300a+CD4+, CD57−CD161−CD300a+CD4+, CD57+CD161−CD300a+CD8+, CD57−CD161−CD300a+CD8+, CD57+CD161−CD300a+NKT-like, and CD57+CD161−CD300a+DN T-cells. Moreover, in young individuals, CD161 expression on T-cells is not affected by CMV infection. Changes of CD161 expression were only associated with age in the context of CMV latent infection. Besides, CD300a+CD57+CD161+ and CD300a−CD57+CD161+ phenotypes were not found in any of the T-cell subsets studied except in the DN subpopulation, indicating that in the majority of T-cells, CD161 and CD57 do not co-express. Thus, our results show that CMV latent infection impact on the immune system depends on the age of the individual, highlighting the importance of including CMV serology in any study regarding immunosenescence.

  13. Dielectric properties of CdS nanoparticles synthesized by soft ...

    Indian Academy of Sciences (India)

    If the field applied to the condenser is time-dependent (as in an alternating current), so ... tematically the dielectric properties of CdS synthesized by a soft chemical method .... The real parts of conductivity spectra can be explained by the power ...

  14. The Basic Economics of CD-ROM Pricing.

    Science.gov (United States)

    Erkkila, John E.

    1991-01-01

    This explanation of how the basic economic model of pricing applies to the CD-ROM industry considers the supply and demand sides of the market and compares three distinct pricing strategies: (1) pricing to maximize profits; (2) average cost pricing; and (3) marginal cost pricing. (EAM)

  15. Linkage mapping of a dominant male sterility gene Ms-cd1 in Brassica oleracea

    NARCIS (Netherlands)

    Wang, X.; Lou, P.; Bonnema, A.B.; Yang, Boujun; He, H.; Zhang, Y.; Fang, Z.

    2005-01-01

    The dominant male sterility gene Ms-cd1 (c, cabbage; d, dominant) was identified as a spontaneous mutation in the spring cabbage line 79-399-3. The Ms-cd1 gene is successfully applied in hybrid seed production of several Brassica oleracea cultivars in China. Amplified fragment length polymorphism

  16. Automated CD-SEM metrology for efficient TD and HVM

    Science.gov (United States)

    Starikov, Alexander; Mulapudi, Satya P.

    2008-03-01

    CD-SEM is the metrology tool of choice for patterning process development and production process control. We can make these applications more efficient by extracting more information from each CD-SEM image. This enables direct monitors of key process parameters, such as lithography dose and focus, or predicting the outcome of processing, such as etched dimensions or electrical parameters. Automating CD-SEM recipes at the early stages of process development can accelerate technology characterization, segmentation of variance and process improvements. This leverages the engineering effort, reduces development costs and helps to manage the risks inherent in new technology. Automating CD-SEM for manufacturing enables efficient operations. Novel SEM Alarm Time Indicator (SATI) makes this task manageable. SATI pulls together data mining, trend charting of the key recipe and Operations (OPS) indicators, Pareto of OPS losses and inputs for root cause analysis. This approach proved natural to our FAB personnel. After minimal initial training, we applied new methods in 65nm FLASH manufacture. This resulted in significant lasting improvements of CD-SEM recipe robustness, portability and automation, increased CD-SEM capacity and MT productivity.

  17. On-line distance assisted training program for nuclear medicine technologists applied to SPECT-CT and PET-CT (Program DAT-OL). Results of a first course in Argentina

    International Nuclear Information System (INIS)

    Furnari, J C; Notari, C; Daoud, A; Giannone, C A

    2012-01-01

    The CNEA and the IDB are running for the second time the Distance Assisted Training course (DAT-OL), which is part of a global program of the International Atomic Energy Agency (IAEA) for Nuclear Medicine technologists working in centers equipped with PET CT and / or SPECT-CT hybrids. Aims: Completion of this course is justified by the strong increase in the installation of hybrid nuclear medicine (NM) systems, the increasing demand for qualified technicians and the lack of formal training opportunity. The course objective is to both promote the qualification of the technologist as improving quality and operational safety in MN participating centers. Material and Methods: This new course is free and is taught in Spanish from the www.datnmt.org website. The study material is available on site and the training is aided by tutors of institutions as CNEA, FUESMEN (School of Nuclear Medicine Foundation), UBA (University of Buenos Aires) and Nuclear Medicine private labs. The DAT-OL is developed in modules: Physics of SPECT / CT and PET / CT; Principles and sectional anatomy CT, SPECT / CT and PET / CT clinical; cyclotron and radiopharmaceutical production; Radiation Safety in PET / CT; Workflows and protocols with PET / CT, clinical reports: normal variants, artifacts and failures. Some of the requirements to take the DAT-OL are: Access to camera PET / CT and / or camera SPECT / CT, and a supervisor (Nuclear Medicine physician or Medical physicist) at the center of NM where the student works. Technicians must have academic qualification, 5 or more years working in centers MN, previous courses in Biology, Physics SPECT and SPECT Clinical course and a Methodology of Radioisotopes and radiation protection course. Results: The first course lasted 12 months including examinations. Tutors have scarcely been consulted. SPECT/CT and PET/CT web examinations, have been developed and evaluated by the authors of the course (B. Hutton and H. Patterson, University of London and

  18. When is the best moment to apply photobiomodulation therapy (PBMT) when associated to a treadmill endurance-training program? A randomized, triple-blinded, placebo-controlled clinical trial.

    Science.gov (United States)

    Miranda, Eduardo Foschini; Tomazoni, Shaiane Silva; de Paiva, Paulo Roberto Vicente; Pinto, Henrique Dantas; Smith, Denis; Santos, Larissa Aline; de Tarso Camillo de Carvalho, Paulo; Leal-Junior, Ernesto Cesar Pinto

    2018-05-01

    Photobiomodulation therapy (PBMT) employing low-level laser therapy (LLLT) and/or light emitting diode therapy (LEDT) has emerged as an electrophysical intervention that could be associated with aerobic training to enhance beneficial effects of aerobic exercise. However, the best moment to perform irradiation with PBMT in aerobic training has not been elucidated. The aim of this study was to assess the effects of PBMT applied before and/or after each training session and to evaluate outcomes of the endurance-training program associated with PBMT. Seventy-seven healthy volunteers completed the treadmill-training protocol performed for 12 weeks, with 3 sessions per week. PBMT was performed before and/or after each training session (17 sites on each lower limb, using a cluster of 12 diodes: 4 × 905 nm super-pulsed laser diodes, 4 × 875 nm infrared LEDs, and 4 × 640 nm red LEDs, dose of 30 J per site). Volunteers were randomized in four groups according to the treatment they would receive before and after each training session: PBMT before + PBMT after, PBMT before + placebo after, placebo before + PBMT after, and placebo before + placebo after. Assessments were performed before the start of the protocol and after 4, 8, and 12 weeks of training. Primary outcome was time until exhaustion; secondary outcome measures were oxygen uptake and body fat. PBMT applied before and after aerobic exercise training sessions (PBMT before + PBMT after group) significantly increased (p training sessions (placebo before + placebo after group) at 4th, 8th, and 12th week. PBMT applied before and after aerobic exercise training sessions (PBMT before + PBMT after group) also significantly improved (p training sessions (placebo before + placebo after group) at 8th and 12th week. PBMT applied before and after sessions of aerobic training during 12 weeks can increase the time-to-exhaustion and oxygen uptake and also decrease the body fat in healthy volunteers when

  19. Mn2+ anchored CdS polymer nanocomposites: An efficient alternative for Mn2+ doped CdS nanoparticles

    International Nuclear Information System (INIS)

    Saikia, Bhaskar Jyoti; Nath, Bikash Chandra; Borah, Chandramika; Dolui, Swapan Kumar

    2015-01-01

    A chelating bi-functional polymer brushes was prepared via atom transfer radical polymerization using grafting-from methodology. Mn 2+ -anchored CdS-polymer nanocomposites were synthesized using this graft copolymer by simple chelation method resulting in emission at about 620 nm which originates from the fluorescence of manganese ions embedded on the surface of CdS nanoparticles. This method provides an efficient straightforward substitute of Mn 2+ dopped CdS nanoparticles. Optical properties of the composites were investigated which indicates that simple Mn 2+ chelation and subsequent binding of CdS in a polymer matrix can have similar effect in the luminescence property as those synthesized via complex doping methods. Moreover this methodology can be applied for synthesis of any metal anchored nanocomposites proficiently and cost effectively in large-scale production. - Highlights: • A chelating bifunctional copolymer brush was synthesized via ATRP. • CdS nanoparticles and Mn 2+ were coupled with the bifunctional polymer. • Composites showed emission properties similar to Mn 2+ doped CdS nanoparticles. • Side chain length of the polymers also affect the emission properties of the composites.

  20. CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis

    Science.gov (United States)

    McNally, Alice; Hill, Geoffrey R.; Sparwasser, Tim; Thomas, Ranjeny; Steptoe, Raymond J.

    2011-01-01

    CD4+CD25+ regulatory T cells (Treg) play a crucial role in the regulation of immune responses. Although many mechanisms of Treg suppression in vitro have been described, the mechanisms by which Treg modulate CD8+ T cell differentiation and effector function in vivo are more poorly defined. It has been proposed, in many instances, that modulation of cytokine homeostasis could be an important mechanism by which Treg regulate adaptive immunity; however, direct experimental evidence is sparse. Here we demonstrate that CD4+CD25+ Treg, by critically regulating IL-2 homeostasis, modulate CD8+ T-cell effector differentiation. Expansion and effector differentiation of CD8+ T cells is promoted by autocrine IL-2 but, by competing for IL-2, Treg limit CD8+ effector differentiation. Furthermore, a regulatory loop exists between Treg and CD8+ effector T cells, where IL-2 produced during CD8+ T-cell effector differentiation promotes Treg expansion. PMID:21502514

  1. Size-selective precipitation in colloidal semiconductor nanocrystals of CdTe and CdSe: a study by UV-VIS spectroscopy; Precipitacao seletiva de tamanhos em nanoparticulas semicondutoras coloidais de CdTe e CdSe: um estudo por espectroscopia UV-VIS

    Energy Technology Data Exchange (ETDEWEB)

    Viol, Livia Cristina de Souza; Silva, Fernanda Oliveira; Ferreira, Diego Lourenconi; Alves, Jose Luiz Aarestrup; Schiavon, Marco Antonio, E-mail: schiavon@ufsj.edu.b [Universidade Federal de Sao Joao del Rei, MG (Brazil). Dept. de Ciencias Naturais

    2011-07-01

    The post-preparative size-selective precipitation technique was applied in CdTe and CdSe semiconductor nanocrystals prepared via colloidal route in water. The synthesis of CdTe and CdSe nanoparticles and the effect of the post-preparative size-selective precipitation have been characterized mainly by mean of ultraviolet and visible absorption spectroscopy (UV-Vis). It was demonstrated that the size-selective precipitation are able to isolate particles of different sizes and purify the nanoparticles as well. (author)

  2. Micro-PIXE studies of elemental distribution in Cd-accumulating Brassica juncea L

    International Nuclear Information System (INIS)

    Schneider, Thorsten; Haag-Kerwer, Angela; Maetz, Mischa; Niecke, Manfred; Povh, Bogdan; Rausch, Thomas; Schuessler, Arthur

    1999-01-01

    Brassica juncea L. is a high biomass producing crop plant, being able to accumulate Cd and other heavy metals in their roots and shoots. It is a good candidate for efficient phytoextraction of heavy metals - such as Cd - from polluted soils. PIXE and STIM analyses were applied to investigate Cd-uptake in roots and the resulting effects on the elemental distribution of Cd stressed plants. The axial distribution of trace elements as a function of distance from the root tip as well as the radial distribution within cross-sections were analysed. The results are compared with the elemental distribution in control plants

  3. Micro-PIXE studies of elemental distribution in Cd-accumulating Brassica juncea L.

    Science.gov (United States)

    Schneider, Thorsten; Haag-Kerwer, Angela; Maetz, Mischa; Niecke, Manfred; Povh, Bogdan; Rausch, Thomas; Schüßler, Arthur

    1999-10-01

    Brassica juncea L. is a high biomass producing crop plant, being able to accumulate Cd and other heavy metals in their roots and shoots. It is a good candidate for efficient phytoextraction of heavy metals - such as Cd - from polluted soils. PIXE and STIM analyses were applied to investigate Cd-uptake in roots and the resulting effects on the elemental distribution of Cd stressed plants. The axial distribution of trace elements as a function of distance from the root tip as well as the radial distribution within cross-sections were analysed. The results are compared with the elemental distribution in control plants.

  4. Micro-PIXE studies of elemental distribution in Cd-accumulating Brassica juncea L

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, Thorsten E-mail: thorsten.schneider@mpi-hd.mpg.de; Haag-Kerwer, Angela; Maetz, Mischa; Niecke, Manfred; Povh, Bogdan; Rausch, Thomas; Schuessler, Arthur

    1999-09-02

    Brassica juncea L. is a high biomass producing crop plant, being able to accumulate Cd and other heavy metals in their roots and shoots. It is a good candidate for efficient phytoextraction of heavy metals - such as Cd - from polluted soils. PIXE and STIM analyses were applied to investigate Cd-uptake in roots and the resulting effects on the elemental distribution of Cd stressed plants. The axial distribution of trace elements as a function of distance from the root tip as well as the radial distribution within cross-sections were analysed. The results are compared with the elemental distribution in control plants.

  5. Applied mechanics of solids

    CERN Document Server

    Bower, Allan F

    2009-01-01

    Modern computer simulations make stress analysis easy. As they continue to replace classical mathematical methods of analysis, these software programs require users to have a solid understanding of the fundamental principles on which they are based. Develop Intuitive Ability to Identify and Avoid Physically Meaningless Predictions Applied Mechanics of Solids is a powerful tool for understanding how to take advantage of these revolutionary computer advances in the field of solid mechanics. Beginning with a description of the physical and mathematical laws that govern deformation in solids, the text presents modern constitutive equations, as well as analytical and computational methods of stress analysis and fracture mechanics. It also addresses the nonlinear theory of deformable rods, membranes, plates, and shells, and solutions to important boundary and initial value problems in solid mechanics. The author uses the step-by-step manner of a blackboard lecture to explain problem solving methods, often providing...

  6. [Changes of CD34(+) and CD71(+)CD45(-) cell levels in bone marrow of MDS and AA patients].

    Science.gov (United States)

    Yan, Zhen-Yu; Tian, Xu; Li, Ying; Yang, Mei-Rong; Zhang, Song; Wang, Xie-Ming; Zhang, Hai-Xia; Cheng, Nai-Yao

    2014-04-01

    This study was aimed to investigate the changes of CD34(+) and CD71(+)CD45(-) cell levels in MDS and AA patients. A total of 25 cases MDS and 43 cases of AA (18 cases SAA and 25 cases of NSAA) from January 2010 to October 2013 in the Department of Hematology, affiliated hospital of Hebei United University were enrolled in this study. The complete blood count, bone marrow smears, bone marrow biopsy, karyotype analysis and bone marrow blood cell immune genotyping (mainly the proportion of CD34(+) cells, CD71(+)CD45(-) cells in nucleated cells) were carried out for all patients; the changes of CD34(+) and CD71(+)CD45(-) cell levels in patients with MDS and AA (SAA NSAA) were compared; the differences of white blood cell count, platelet count and hemoglobin concentration in patients with count of CD71(+)CD45(-) ≥ 15% or MDS group was higher than that in AA (NSAA and SAA) group (P MDS group was higher than that in SAA (P MDS group. In MDS group with CD71(+)CD45(-) ≥ 15%, the platelet count was significantly higher than that in NSAA group (P MDS and NSAA group with CD71(+)CD45(-) 0.05). It is concluded that the count of CD34(+) cells in MDS patients is significantly higher than that in AA and SAA patients. The count of CD71(+)CD45(-) cells in MDS group is significantly higher than that of SAA group. The platelet count in MDS patients with CD71(+)CD45(-) cells ≥ 15% is significantly higher than that of the NSAA group.

  7. Percentage and function of CD4+CD25+ regulatory T cells in patients with hyperthyroidism

    Science.gov (United States)

    Jiang, Ting-Jun; Cao, Xue-Liang; Luan, Sha; Cui, Wan-Hui; Qiu, Si-Huang; Wang, Yi-Chao; Zhao, Chang-Jiu; Fu, Peng

    2018-01-01

    The current study observed the percentage of peripheral blood (PB) CD4+CD25+ regulatory T cells (Tregs) and the influence of CD4+CD25+ Tregs on the proliferation of naïve CD4 T cells in patients with hyperthyroidism. Furthermore, preliminary discussions are presented on the action mechanism of CD4+CD25+ Tregs on hyperthyroidism attacks. The present study identified that compared with the percentage of PB CD4+CD25+ Tregs in healthy control subjects, no significant changes were observed in the percentage of PB CD4+CD25+ Tregs in patients with hyperthyroidism (P>0.05). For patients with hyperthyroidism, CD4+CD25+ Tregs exhibited significantly reduced inhibition of the proliferation of naïve CD4 T cells and decreased secretion capacity on the cytokines of CD4 T cells, compared with those of healthy control subjects (Phyperthyroidism was significantly improved (Phyperthyroidism before treatment, no significant changes were observed in the percentage of PB CD4+CD25+ Tregs in hyperthyroidism patients following treatment (P>0.05). In the patients with hyperthyroidism, following treatment, CD4+CD25+ Tregs exhibited significantly increased inhibition of the proliferation of naïve CD4 T cells and increased secretion capacity of CD4 T cell cytokines, compared with those of the patients with hyperthyroidism prior to treatment (Phyperthyroidism, and its non-proportional decrease may be closely associated with the occurrence and progression of hyperthyroidism. PMID:29207121

  8. CD4/CD8/Dendritic cell complexes in the spleen: CD8+ T cells can directly bind CD4+ T cells and modulate their response

    Science.gov (United States)

    Barinov, Aleksandr; Galgano, Alessia; Krenn, Gerald; Tanchot, Corinne; Vasseur, Florence

    2017-01-01

    CD4+ T cell help to CD8+ T cell responses requires that CD4+ and CD8+ T cells interact with the same antigen presenting dendritic cell (Ag+DC), but it remains controversial whether helper signals are delivered indirectly through a licensed DC and/or involve direct CD4+/CD8+ T cell contacts and/or the formation of ternary complexes. We here describe the first in vivo imaging of the intact spleen, aiming to evaluate the first interactions between antigen-specific CD4+, CD8+ T cells and Ag+DCs. We show that in contrast to CD4+ T cells which form transient contacts with Ag+DC, CD8+ T cells form immediate stable contacts and activate the Ag+DC, acquire fragments of the DC membranes by trogocytosis, leading to their acquisition of some of the DC properties. They express MHC class II, and become able to present the specific Marilyn peptide to naïve Marilyn CD4+ T cells, inducing their extensive division. In vivo, these CD8+ T cells form direct stable contacts with motile naïve CD4+ T cells, recruiting them to Ag+DC binding and to the formation of ternary complexes, where CD4+ and CD8+ T cells interact with the DC and with one another. The presence of CD8+ T cells during in vivo immune responses leads to the early activation and up-regulation of multiple functions by CD4+ T lymphocytes. Thus, while CD4+ T cell help is important to CD8+ T cell responses, CD8+ T cells can interact directly with naïve CD4+ T cells impacting their recruitment and differentiation. PMID:28686740

  9. Diffusion of Cd and Te adatoms on CdTe(111) surfaces: A computational study using density functional theory

    Energy Technology Data Exchange (ETDEWEB)

    Naderi, Ebadollah, E-mail: enaderi42@gmail.com [Department of Physics, Savitribai Phule Pune University (SPPU), Pune-411007 (India); Nanavati, Sachin [Center for Development of Advanced Computing (C-DAC), SPPU campus, Pune 411007 (India); Majumder, Chiranjib [Chemistry Division, Bhabha Atomic Research Center, Mumbai, 400085 (India); Ghaisas, S. V. [Department of Electronic Science, Savitribai Phule Pune University (SPPU), Pune-411007 (India); Department of Physics, Savitribai Phule Pune University (SPPU), Pune-411007 (India)

    2015-01-15

    CdTe is one of the most promising semiconductor for thin-film based solar cells. Here we report a computational study of Cd and Te adatom diffusion on the CdTe (111) A-type (Cd terminated) and B-type (Te terminated) surfaces and their migration paths. The atomic and electronic structure calculations are performed under the DFT formalism and climbing Nudge Elastic Band (cNEB) method has been applied to evaluate the potential barrier of the Te and Cd diffusion. In general the minimum energy site on the surface is labeled as A{sub a} site. In case of Te and Cd on B-type surface, the sub-surface site (a site just below the top surface) is very close in energy to the A site. This is responsible for the subsurface accumulation of adatoms and therefore, expected to influence the defect formation during growth. The diffusion process of adatoms is considered from A{sub a} (occupied) to A{sub a} (empty) site at the nearest distance. We have explored three possible migration paths for the adatom diffusion. The adatom surface interaction is highly dependent on the type of the surface. Typically, Te interaction with both type (5.2 eV for A-type and 3.8 eV for B-type) is stronger than Cd interactions(2.4 eV for B-type and 0.39 eV for A-type). Cd interaction with the A-type surface is very weak. The distinct behavior of the A-type and B-type surfaces perceived in our study explain the need of maintaining the A-type surface during growth for smooth and stoichiometric growth.

  10. Diffusion of Cd and Te adatoms on CdTe(111) surfaces: A computational study using density functional theory

    Science.gov (United States)

    Naderi, Ebadollah; Nanavati, Sachin; Majumder, Chiranjib; Ghaisas, S. V.

    2015-01-01

    CdTe is one of the most promising semiconductor for thin-film based solar cells. Here we report a computational study of Cd and Te adatom diffusion on the CdTe (111) A-type (Cd terminated) and B-type (Te terminated) surfaces and their migration paths. The atomic and electronic structure calculations are performed under the DFT formalism and climbing Nudge Elastic Band (cNEB) method has been applied to evaluate the potential barrier of the Te and Cd diffusion. In general the minimum energy site on the surface is labeled as Aa site. In case of Te and Cd on B-type surface, the sub-surface site (a site just below the top surface) is very close in energy to the A site. This is responsible for the subsurface accumulation of adatoms and therefore, expected to influence the defect formation during growth. The diffusion process of adatoms is considered from Aa (occupied) to Aa (empty) site at the nearest distance. We have explored three possible migration paths for the adatom diffusion. The adatom surface interaction is highly dependent on the type of the surface. Typically, Te interaction with both type (5.2 eV for A-type and 3.8 eV for B-type) is stronger than Cd interactions(2.4 eV for B-type and 0.39 eV for A-type). Cd interaction with the A-type surface is very weak. The distinct behavior of the A-type and B-type surfaces perceived in our study explain the need of maintaining the A-type surface during growth for smooth and stoichiometric growth.

  11. The influence of humic substance on Cd accumulation of phytostabilizer Athyrium wardii (Hook.) grown in Cd-contaminated soils.

    Science.gov (United States)

    Zhan, Juan; Li, Tingxuan; Yu, Haiying; Zhang, Xizhou; Zhao, Li

    2016-09-01

    The application of organic amendments into heavy metal contaminated soil is considered as an environmentally friendly technique to promote the potential of phytoremediation. A pot experiment was carried out to evaluate the effect of humic substances on growth, cadmium (Cd) accumulation and phytostabilization potential of the mining ecotype (ME) and the corresponding non-mining ecotype (NME) of Athyrium wardii (Hook.) grown in Cd-contaminated soils. The addition of the humic substances demonstrated great promotion for the growth and Cd uptake of ME. Both plant biomass and Cd concentration significantly increased with the increasing application of the humic substances up to 100 g kg(-1), beyond which no significant change of underground part biomass and Cd concentrations in underground part of A. wardii was observed. The maximum Cd concentration in underground part of ME was 180 mg kg(-1) when 150 g kg(-1) humic substances were applied. The ME showed greater Cd accumulation capability in underground part (0.47-0.68 mg plant(-1)) than that of NME (0.27-0.45 mg plant(-1)). Increasing bioaccumulation coefficient (BCF) values of A. wardii was observed with increasing application of the humic substances. The BCF values of ME were higher than those of NME. However, the use of the humic substances exhibited little impact on translocation factors (TFs) of ME, and the TF values of ME were less than NME. Furthermore, the application of the humic substances improved the remediation factors (RFs) of A. wardii. The RF values in underground part of ME ranging from 0.73 to 0.91 % were apparently higher than those of NME. These results indicated that the humic substances can be a potential candidate for enhancing the phytostabilization of A. wardii grown in Cd-contaminated soils.

  12. Diffusion of Cd and Te adatoms on CdTe(111) surfaces: A computational study using density functional theory

    International Nuclear Information System (INIS)

    Naderi, Ebadollah; Nanavati, Sachin; Majumder, Chiranjib; Ghaisas, S. V.

    2015-01-01

    CdTe is one of the most promising semiconductor for thin-film based solar cells. Here we report a computational study of Cd and Te adatom diffusion on the CdTe (111) A-type (Cd terminated) and B-type (Te terminated) surfaces and their migration paths. The atomic and electronic structure calculations are performed under the DFT formalism and climbing Nudge Elastic Band (cNEB) method has been applied to evaluate the potential barrier of the Te and Cd diffusion. In general the minimum energy site on the surface is labeled as A a site. In case of Te and Cd on B-type surface, the sub-surface site (a site just below the top surface) is very close in energy to the A site. This is responsible for the subsurface accumulation of adatoms and therefore, expected to influence the defect formation during growth. The diffusion process of adatoms is considered from A a (occupied) to A a (empty) site at the nearest distance. We have explored three possible migration paths for the adatom diffusion. The adatom surface interaction is highly dependent on the type of the surface. Typically, Te interaction with both type (5.2 eV for A-type and 3.8 eV for B-type) is stronger than Cd interactions(2.4 eV for B-type and 0.39 eV for A-type). Cd interaction with the A-type surface is very weak. The distinct behavior of the A-type and B-type surfaces perceived in our study explain the need of maintaining the A-type surface during growth for smooth and stoichiometric growth

  13. Development of Buffer Layer Technologies for LWIR and VLWIR HgCdTe Integration on Si

    National Research Council Canada - National Science Library

    Golding, Terry D

    2005-01-01

    This program proposed to develop manufacturable, cost-effective buffer layer technologies that would allow either hybrid or monolithic integration of LWIR and VLWIR HgCdTe infrared focal plane arrays...

  14. Occupational Analysis Products: Space Systems Operations - AFSC 1C6X1 (CD-ROM)

    National Research Council Canada - National Science Library

    Boerstler, Robert E

    2004-01-01

    ...: 1 CD-ROM; 4 3/4 in.; 30.4 MB. SYSTEMS DETAIL NOTE: ABSTRACT: The Space Systems Operations career ladder was surveyed to obtain current task and equipment data for use in evaluating current training programs...

  15. CD4-regulatory cells in COPD patients

    DEFF Research Database (Denmark)

    Smyth, Lucy J C; Starkey, Cerys; Vestbo, Jørgen

    2007-01-01

    BACKGROUND: The numbers of airway CD8 and B lymphocytes are increased in COPD patients, suggesting an autoimmune process. CD4-regulatory T cells control autoimmunity but have not been studied in patients with COPD. OBJECTIVE: To compare T-regulatory cell numbers in the BAL from COPD patients......, smokers with normal lung function, and healthy nonsmokers (HNS). METHODS: BAL and peripheral blood mononuclear cell (PBMC) samples were obtained from 26 COPD patients, 19 smokers, and 8 HNS. Flow cytometry was performed for regulatory phenotypic markers. RESULTS: COPD patients had increased BAL CD8...... numbers compared to smokers and HNS. CD4 numbers were similar between groups. There was increased BAL CD4CD25(bright) expression in smokers (median 28.8%) and COPD patients (median 23.1%) compared to HNS (median 0%). Increased FoxP3 expression was confirmed in BAL CD4CD25(bright) cells. BAL CD4CD25 cells...

  16. CD27 instructs CD4+ T cells to provide help for the memory CD8+ T cell response after protein immunization

    NARCIS (Netherlands)

    Xiao, Yanling; Peperzak, Victor; Keller, Anna M.; Borst, Jannie

    2008-01-01

    For optimal quality, memory CD8(+) T cells require CD4(+) T cell help. We have examined whether CD4(+) T cells require CD27 to deliver this help, in a model of intranasal OVA protein immunization. CD27 deficiency reduced the capacity of CD4(+) T cells to support Ag-specific CD8(+) T cell

  17. Soil-applied zinc and copper suppress cadmium uptake and improve the performance of cereals and legumes.

    Science.gov (United States)

    Murtaza, Ghulam; Javed, Wasim; Hussain, Amir; Qadir, Manzoor; Aslam, Muhammad

    2017-02-01

    The present study aimed to evaluate the effect of soil-applied Zn and Cu on absorption and accumulation of Cd applied through irrigation water in legume (chickpea and mung bean) and cereal (wheat and maize) crops. The results revealed that Cd in irrigation water at higher levels (2 and 5 mg L -1 ) significantly (p soil application of Zn and Cu, singly or combined, favored the biomass production. Plant tissue Cd concentration increased linearly with the increasing application of Cd via irrigation water. While Cd application caused a redistribution of metals in grains, straw, and roots with the highest concentration of Cd, Zn, and Cu occurred in roots followed by straw and grains. Zinc addition to soil alleviated Cd toxicity by decreasing Cd concentration in plant tissues due to a possible antagonistic effect. The addition of Cu to the soil had no consistent effects on Zn and Cd contents across all crops. Inhibitory effects of Cd on the uptake and accumulation of Zn and Cu have also been observed at higher Cd load. Thus, soil-applied Zn and Cu antagonized Cd helping the plant to cope with its toxicity and suppressed the toxic effects of Cd in plant tissues, thus favoring plant growth.

  18. Effect of curcumin on the cell surface markers CD44 and CD24 in breast cancer.

    Science.gov (United States)

    Calaf, Gloria M; Ponce-Cusi, Richard; Abarca-Quinones, Jorge

    2018-04-20

    Human breast cell lines are often characterized based on the expression of the cell surface markers CD44 and CD24. CD44 is a type I transmembrane glycoprotein that regulates cell adhesion and cell-cell, as well as cell-extracellular matrix interactions. CD24 is expressed in benign and malignant solid tumors and is also involved in cell adhesion and metastasis. The aim of the present study was to investigate the effects of curcumin on the surface expression of CD44 and CD24 in breast epithelial cell lines. An established breast cancer model derived from the MCF-10F cell line was used. The results revealed that curcumin decreased CD44 and CD24 gene and protein expression levels in MCF-10F (normal), Alpha5 (premalignant) and Tumor2 (malignant) cell lines compared with the levels in their counterpart control cells. Flow cytometry revealed that the CD44+/CD24+ cell subpopulation was greater than the CD44+/CD24- subpopulation in these three cell lines. Curcumin increased CD44+/CD24+ to a greater extent and decreased CD44+/CD24- subpopulations in the normal MCF-10F and the pre-tumorigenic Alpha5 cells, but had no significant effect on Tumor2 cells compared with the corresponding control cells. Conversely, curcumin increased CD44 and decreased CD24 gene expression in MCF-7 breast cancer cells, and decreased CD44 gene expression in MDA-MB-231 cell line, while CD24 was not present in these cells. Curcumin did not alter the CD44+/CD24+ or CD44+/CD24- subpopulations in the MCF-7 cell line. However, it increased CD44+/CD24+ and decreased CD44+/CD24- subpopulations in MDA-MB-231 cells. In breast cancer specimens from patients, normal tissues were negative for CD44 and CD24 expression, while benign lesions were positive for both markers, and malignant tissues were found to be negative for CD44 and positive for CD24 in most cases. In conclusion, these results indicated that curcumin may be used to improve the proportion of CD44+/CD24+ cells and decrease the proportion of CD44

  19. Ocular pharmacokinetics and availability of topically applied baicalein in rabbits.

    Science.gov (United States)

    Zhang, Li; Zhang, Junjie; Wang, Liya; Xia, Huiyun

    2009-04-01

    To evaluate the ocular pharmacokinetics and availability of baicalein following topical application. Hydroxypropyl beta-cyclodextrin (HP-beta -CD) was used to formulate an aqueous eye drop to improve aqueous solubility of baicalein. A single dose of either baicalein suspension (1%) (Bai-SP) or baicalein (1%)/HP-beta-CD (10%) solution (Bai-CD) was topically applied to rabbits. Aqueous humor and cornea were collected after 5, 10, 20, 30, 45, 60, 90, and 120 min. Baicalein concentrations were determined by high-performance liquid chromatography (HPLC) after extraction. After topically applying Bai-CD, the baicalein concentrations in aqueous humor were significantly increased at 20-120 min except at 90 min compared with those of Bai-SP (p cornea (56.53 +/- 17.02 microg/g) was achieved within 5 min after topical application of Bai-CD and 4.5 times higher than that of Bai-SP at the same timepoint. The baicalein levels in corneas obtained after application of Bai-CD were all much higher than those obtained by Bai-SP (p < 0.01), whereas the drug levels became undetectable 30 min after topical application of Bai-SP. Bai-CD formulation is superior to Bai-SP for increasing ocular bioavailability.

  20. Atomic structures of Cd Te and Cd Se (110) surfaces

    International Nuclear Information System (INIS)

    Watari, K.; Ferraz, A.C.

    1996-01-01

    Results are reported based on the self-consistent density-functional theory, within the local-density approximation using ab-initio pseudopotentials of clean Cd Te and Cd Se (110) surfaces. We analyzed the trends for the equilibrium atomic structures, and the variations of the bond angles at the II-VI (110). The calculations are sensitive to the ionicity of the materials and the results are in agreement with the arguments which predict that the relaxed zinc-blend (110) surfaces should depend on ionicity. (author). 17 refs., 1 figs., 3 tabs

  1. CD103 is a marker for alloantigen-induced regulatory CD8+ T cells

    NARCIS (Netherlands)

    Uss, Elena; Rowshani, Ajda T.; Hooibrink, Berend; Lardy, Neubury M.; van Lier, René A. W.; ten Berge, Ineke J. M.

    2006-01-01

    The alphaEbeta7 integrin CD103 may direct lymphocytes to its ligand E-cadherin. CD103 is expressed on T cells in lung and gut and on allograft-infiltrating T cells. Moreover, recent studies have documented expression of CD103 on CD4+ regulatory T cells. Approximately 4% of circulating CD8+ T cells

  2. Preferential replication of FIV in activated CD4+CD25+T cells independent of cellular proliferation

    International Nuclear Information System (INIS)

    Joshi, Anjali; Vahlenkamp, Thomas W.; Garg, Himanshu; Tompkins, Wayne A.F.; Tompkins, Mary B.

    2004-01-01

    Studies attempting to identify reservoirs of HIV-1 latency have documented that the virus persists as both a latent and productive infection in subsets of CD4 + cells. Reports regarding establishment of a stable HIV-1 infection in quiescent T cells in vitro, however, are controversial. In the present study, we investigated the susceptibility of naive and activated CD4 + cell subsets (distinguished by differential expression of CD25) to feline immunodeficiency virus (FIV) infection, their ability to replicate the virus, and potentially act as a reservoir for virus persistence in infected animals. While both CD4 + CD25 + and CD4 + CD25 - cells are susceptible to FIV infection in vitro and in vivo, only CD4 + CD25 + cells produce infectious virions when cultured with interleukin-2 (IL-2). Latently infected CD4 + CD25 - cells produce infectious virions following ConcanvalinA (ConA) stimulation, which correlates with upregulated surface expression of CD25. In contrast to CD4 + CD25 - cells, CD4 + CD25 + cells remain unresponsive to mitogen stimulation and are relatively resistant to apoptosis whether or not infected with FIV. The ability of CD4 + CD25 + cells to replicate FIV efficiently in the presence of IL-2 but remain anergic and unresponsive to apoptotic signaling suggests that these cells may provide a reservoir of productive FIV infection. On the contrary, CD4 + CD25 - cells seem to establish as latent viral reservoirs capable of being reactivated after stimulation

  3. Dissection of a circulating CD3+ CD20+ T cell subpopulation in patients with psoriasis.

    Science.gov (United States)

    Niu, J; Zhai, Z; Hao, F; Zhang, Y; Song, Z; Zhong, H

    2018-05-01

    CD3 + CD20 + T cells are a population of CD3 + T cells that express CD20 and identified in healthy donors and autoimmune diseases. However, the nature and role of these cells in patients with psoriasis remain unclear. In this study, we aimed to investigate the level, phenotype, functional and clinical relevance of CD3 + CD20 + T cells in the peripheral blood of patients with psoriasis. We found that a small subset of CD3 + T cells expressed CD20 molecule in the peripheral blood of patients with psoriasis, and their levels were similar to those in healthy donors. Circulating CD3 + CD20 + T cells in patients with psoriasis were enriched in CD4 + cells and displayed an activated effector phenotype, as these cells contained fewer CD45RA + -naive and CCR7 + cells with increased activity than those of CD3 + T cells lacking CD20. In addition, compared with healthy donors, circulating CD3 + CD20 + T cells in patients with psoriasis produced more cytokines, interleukin (IL)-17A, tumour necrosis factor (TNF)-α and IL-21, but not IL-4 and IFN-γ. Furthermore, a significantly positive correlation was found between the levels of IL-17A, TNF-α and IL-21-production CD3 + CD20 + T cells with Psoriasis Area and Severity Index scores. Our findings suggest that CD3 + CD20 + T cells may play a role in the pathogenesis of psoriasis. © 2018 British Society for Immunology.

  4. Percentages of CD4+CD161+ and CD4−CD8−CD161+ T Cells in the Synovial Fluid Are Correlated with Disease Activity in Rheumatoid Arthritis

    Directory of Open Access Journals (Sweden)

    Jinlin Miao

    2015-01-01

    Full Text Available Objective. CD161 has been identified as a marker of human IL-17-producing T cells that are implicated in the pathogenesis of rheumatoid arthritis (RA. This study aimed to investigate the potential link between the percentage of CD161+ T cells and disease activity in RA patients. Methods. Peripheral blood (PB from 54 RA patients and 21 healthy controls was evaluated. Paired synovial fluid (SF (n = 17 was analyzed. CD161 expression levels on CD4+, CD8+, and CD4−CD8− T cells were assessed by flow cytometry. Results. The percentage of CD4+CD161+ T cells in RA SF was higher than RA PB, and it was positively correlated with DAS28, erythrocyte sedimentation rate (ESR, and C-reactive protein (CRP. CD4−CD8−CD161+ T cell percentage was decreased in RA PB and was further reduced in RA SF, and its level in SF was inversely correlated with DAS28, ESR, and CRP. However, CD8+CD161+ T cell percentage was neither changed in RA PB and SF nor correlated with disease activity indices. Conclusion. An increased CD4+CD161+ T cell percentage and a decreased CD4−CD8−CD161+ T cell percentage are present in RA SF and are associated with disease activity, and the accumulation of CD4+CD161+ T cells in SF may contribute to the local inflammation of RA.

  5. Achievement report for fiscal 1997 on development of technologies for practical photovoltaic system under New Sunshine Program. Manufacture of thin-film solar cell and of low-cost/large-area module (Manufacture of high-reliability CdTe solar module); 1997 nendo taiyoko hatsuden system jitsuyoka gijutsu kaihatsu seika hokokusho. Usumaku taiyo denchi no seizo gijutsu kaihatsu, tei cost daimenseki module seizo gijutsu kaihatsu (koshinraisei CdTe taiyo denchi module no seizo gijutsu kaihatsu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    The target is a low-cost CdS/CdTe solar cell of a large area (60cm times 90cm), the establishment of mass-production technologies for the cell, and the enhancement of production efficiency. A thin film formation technology of subjecting CdS film organic metal to pyrolysis is established, which reduces photoabsorption loss in the shortwave domain of wavelength of not longer than 500nm, reduces reflection loss in the film, and improves on short-circuit current density. Improvement is also achieved on CdTe film quality and junction quality by use of a proximity sublimation method in a vacuum, when a conversion rate of 16.0% (1cm{sup 2}) is attained which is the highest in the world. Based on the results of the above-said efforts, a 3.3mm-thick glass substrate is employed for CdTe film to develop into a 30cm times 60cm-large size, with the film thereon uniformly thick over a large area thanks to a normal pressure proximity sublimation method. Studies are made toward a process nearer to the ultimate product and, using the patterning technique, a 30cm times 60cm-large CdTe solar cell is tentatively built realizing a conversion rate of 9.8%. (NEDO)

  6. Expression of a retinoic acid signature in circulating CD34 cells from coronary artery disease patients

    Directory of Open Access Journals (Sweden)

    van der Laan Anja M

    2010-06-01

    Full Text Available Abstract Background Circulating CD34+ progenitor cells have the potential to differentiate into a variety of cells, including endothelial cells. Knowledge is still scarce about the transcriptional programs used by CD34+ cells from peripheral blood, and how these are affected in coronary artery disease (CAD patients. Results We performed a whole genome transcriptome analysis of CD34+ cells, CD4+ T cells, CD14+ monocytes, and macrophages from 12 patients with CAD and 11 matched controls. CD34+ cells, compared to other mononuclear cells from the same individuals, showed high levels of KRAB box transcription factors, known to be involved in gene silencing. This correlated with high expression levels in CD34+ cells for the progenitor markers HOXA5 and HOXA9, which are known to control expression of KRAB factor genes. The comparison of expression profiles of CD34+ cells from CAD patients and controls revealed a less naïve phenotype in patients' CD34+ cells, with increased expression of genes from the Mitogen Activated Kinase network and a lowered expression of a panel of histone genes, reaching levels comparable to that in more differentiated circulating cells. Furthermore, we observed a reduced expression of several genes involved in CXCR4-signaling and migration to SDF1/CXCL12. Conclusions The altered gene expression profile of CD34+ cells in CAD patients was related to activation/differentiation by a retinoic acid-induced differentiation program. These results suggest that circulating CD34+ cells in CAD patients are programmed by retinoic acid, leading to a reduced capacity to migrate to ischemic tissues.

  7. CD-SEM real time bias correction using reference metrology based modeling

    Science.gov (United States)

    Ukraintsev, V.; Banke, W.; Zagorodnev, G.; Archie, C.; Rana, N.; Pavlovsky, V.; Smirnov, V.; Briginas, I.; Katnani, A.; Vaid, A.

    2018-03-01

    Accuracy of patterning impacts yield, IC performance and technology time to market. Accuracy of patterning relies on optical proximity correction (OPC) models built using CD-SEM inputs and intra die critical dimension (CD) control based on CD-SEM. Sub-nanometer measurement uncertainty (MU) of CD-SEM is required for current technologies. Reported design and process related bias variation of CD-SEM is in the range of several nanometers. Reference metrology and numerical modeling are used to correct SEM. Both methods are slow to be used for real time bias correction. We report on real time CD-SEM bias correction using empirical models based on reference metrology (RM) data. Significant amount of currently untapped information (sidewall angle, corner rounding, etc.) is obtainable from SEM waveforms. Using additional RM information provided for specific technology (design rules, materials, processes) CD extraction algorithms can be pre-built and then used in real time for accurate CD extraction from regular CD-SEM images. The art and challenge of SEM modeling is in finding robust correlation between SEM waveform features and bias of CD-SEM as well as in minimizing RM inputs needed to create accurate (within the design and process space) model. The new approach was applied to improve CD-SEM accuracy of 45 nm GATE and 32 nm MET1 OPC 1D models. In both cases MU of the state of the art CD-SEM has been improved by 3x and reduced to a nanometer level. Similar approach can be applied to 2D (end of line, contours, etc.) and 3D (sidewall angle, corner rounding, etc.) cases.

  8. Detection and Significance of CD4+CD25+CD127dim Regulatory T Cells in Individuals with Severe Aplastic Anemia

    Directory of Open Access Journals (Sweden)

    Weiwei Qi

    2015-09-01

    Full Text Available Objective: To investigate the relationship between CD4+CD25+CD127dim regulatory T cells (Tregs and immune imbalance in acquired severe aplastic anemia (SAA. Materials and Methods: The quantity of CD4+CD25+CD127dim Tregs in 44 SAA patients and 23 normal controls was measured by flow cytometry. Correlations between Tregs and T cell subsets, dendritic cell (DC subsets, granulocyte counts, and percentage of reticulocytes (RET% were analyzed. Results: The percentage of CD4+CD25+CD127dim Tregs in peripheral blood lymphocytes (PBLs of untreated patients was lower than in recovery patients and normal controls (0.83±0.44% vs. 2.91±1.24% and 2.18±0.55%, respectively, p<0.05. The percentage of CD4+CD25+CD127dim Tregs in CD4+ T lymphocytes of recovery patients was higher than that of untreated patients and normal controls (9.39±3.51% vs. 7.61±5.3% and 6.83±1.4%, respectively, p<0.05. The percentage of CD4+ T lymphocytes in PBLs of untreated patients was lower than in recovery patients and normal controls (13.55±7.37% vs. 31.82±8.43% and 32.12±5.88%, respectively, p<0.05. T cell subset (CD4+/CD8+ ratio was 0.41±0.24 in untreated patients, which was lower than in recovery patients (1.2±0.4 and normal controls (1.11±0.23 (p<0.05. DC subset (myeloid DC/plasmacytoid DC ratio, DC1/DC2 ratio was 3.08±0.72 in untreated patients, which was higher than in recovery patients (1.61±0.49 and normal controls (1.39±0.36 (p<0.05. The percentage of CD4+CD25+CD127dim Tregs in PBLs was positively associated with T cell subset (r=0.955, p<0.01 and negatively associated with DC subset (r=-0.765, p<0.01. There were significant positive correlations between CD4+CD25+CD127dim Tregs/PBL and granulocyte counts and RET% (r=0.739 and r=0.749, respectively, p<0.01. Conclusion: The decrease of CD4+CD25+CD127dim Tregs in SAA patients may cause excessive functioning of T lymphocytes and thus lead to hematopoiesis failure in SAA.

  9. Caldwell University's Department of Applied Behavior Analysis.

    Science.gov (United States)

    Reeve, Kenneth F; Reeve, Sharon A

    2016-05-01

    Since 2004, faculty members at Caldwell University have developed three successful graduate programs in Applied Behavior Analysis (i.e., PhD, MA, non-degree programs), increased program faculty from two to six members, developed and operated an on-campus autism center, and begun a stand-alone Applied Behavior Analysis Department. This paper outlines a number of strategies used to advance these initiatives, including those associated with an extensive public relations campaign. We also outline challenges that have limited our programs' growth. These strategies, along with a consideration of potential challenges, might prove useful in guiding academicians who are interested in starting their own programs in behavior analysis.

  10. 32 CFR 37.1220 - Applied research.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Applied research. 37.1220 Section 37.1220... REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1220 Applied research..., Development, Test and Evaluation programs within Budget Activity 2, Applied Research (also known informally as...

  11. Changes in Reactivity In Vitro of CD4+CD25+ and CD4+CD25− T Cell Subsets in Transplant Tolerance

    Science.gov (United States)

    Hall, Bruce M.; Robinson, Catherine M.; Plain, Karren M.; Verma, Nirupama D.; Tran, Giang T.; Nomura, Masaru; Carter, Nicole; Boyd, Rochelle; Hodgkinson, Suzanne J.

    2017-01-01

    Transplant tolerance induced in adult animals is mediated by alloantigen-specific CD4+CD25+ T cells, yet in many models, proliferation of CD4+ T cells from hosts tolerant to specific-alloantigen in vitro is not impaired. To identify changes that may diagnose tolerance, changes in the patterns of proliferation of CD4+, CD4+CD25+, and CD4+CD25− T cells from DA rats tolerant to Piebald Virol Glaxo rat strain (PVG) cardiac allografts and from naïve DA rats were examined. Proliferation of CD4+ T cells from both naïve and tolerant hosts was similar to both PVG and Lewis stimulator cells. In mixed lymphocyte culture to PVG, proliferation of naïve CD4+CD25− T cells was greater than naïve CD4+ T cells. In contrast, proliferation of CD4+CD25− T cells from tolerant hosts to specific-donor PVG was not greater than CD4+ T cells, whereas their response to Lewis and self-DA was greater than CD4+ T cells. Paradoxically, CD4+CD25+ T cells from tolerant hosts did not proliferate to PVG, but did to Lewis, whereas naïve CD4+CD25+ T cells proliferate to both PVG and Lewis but not to self-DA. CD4+CD25+ T cells from tolerant, but not naïve hosts, expressed receptors for interferon (IFN)-γ and IL-5 and these cytokines promoted their proliferation to specific-alloantigen PVG but not to Lewis or self-DA. We identified several differences in the patterns of proliferation to specific-donor alloantigen between cells from tolerant and naïve hosts. Most relevant is that CD4+CD25+ T cells from tolerant hosts failed to proliferate or suppress to specific donor in the absence of either IFN-γ or IL-5. The proliferation to third-party and self of each cell population from tolerant and naïve hosts was similar and not affected by IFN-γ or IL-5. Our findings suggest CD4+CD25+ T cells that mediate transplant tolerance depend on IFN−γ or IL-5 from alloactivated Th1 and Th2 cells. PMID:28878770

  12. Cadmium accumulation, gill Cd binding, acclimation, and physiological effects during long term sublethal Cd exposure in rainbow trout

    Energy Technology Data Exchange (ETDEWEB)

    Hollis, L.; McGeer, J.C.; McDonald, D.G.; Wood, C.M. [Department of Biology, McMaster University, Hamilton, Ontario (Canada)

    1999-07-01

    Juvenile rainbow trout, on 3% of body weight daily ration, were exposed to 0 (control), 3, and 10 {mu}g l{sup -1} Cd (as Cd(NO{sub 3}){sub 2} {center_dot} 4H{sub 2}O) in moderately hard (140 mg l{sup -1} as CaCO{sub 3}), alkaline (95 mg l{sup -1} as CaCO{sub 3}, pH 8.0) water for 30 days. Particular attention focused on acclimation, and on whether a gill surface binding model, originally developed in dilute softwater, could be applied in this water quality to fish chronically exposed to Cd. Only the higher Cd concentration caused mortality (30%, in the first few days). The costs of acclimation, if any, in our study were subtle since no significant effects of chronic Cd exposure were seen in growth rate, swimming performance (stamina and U{sub Crit}), routine O{sub 2} consumption, or whole body ion levels. Substantial acclimation occurred in both exposure groups, manifested as 11- to 13-fold increases in 96-h LC{sub 50} values. In water quality regulations, which are based on toxicity tests with non-acclimated fish only, this remarkable protective effect of acclimation is not taken into account. Cd accumulated in a time- and concentration-dependent fashion to 60-120x (gills), 8-20x (liver), 2-7x (carcass), and 5-12x (whole bodies) control levels by 30 days. Chronically accumulated gill Cd could not be removed by ethylenediaminetetraacetic acid (EDTA) challenge. These gill Cd concentrations were 20- to 40-fold greater than levels predicted by the gill-binding model to cause mortality during acute exposure. In short-term gill Cd-binding experiments (up to 70 {mu}g l{sup -1} exposures for 3 h), gill Cd burden increased as predicted in control fish, but was not detectable against the high background concentrations in acclimated fish. In light of these results, Cd uptake/turnover tests were performed using radioactive {sup 109}Cd to improve sensitivity. With this approach, a small saturable binding component was seen, but could not be related to toxic response in

  13. Monoclonal antibodies targeting CD38 in hematological malignancies and beyond

    DEFF Research Database (Denmark)

    van de Donk, Niels W C J; Janmaat, Maarten L.; Mutis, Tuna

    2016-01-01

    CD38 is a multifunctional cell surface protein that has receptor as well as enzyme functions. The protein is generally expressed at low levels on various hematological and solid tissues, while plasma cells express particularly high levels of CD38. The protein is also expressed in a subset of hema...... strong anti-tumor activity in preclinical models. The antibody engages diverse mechanisms of action, including complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, antibody-dependent cellular phagocytosis, programmed cell death, modulation of enzymatic activity...... combination therapies with existing as well as emerging therapies, which are currently evaluated in the clinic. Finally, CD38 antibodies may have a role in the treatment of diseases beyond hematological malignancies, including solid tumors and antibody-mediated autoimmune diseases. © 2016 John Wiley & Sons A....../S. Published by John Wiley & Sons Ltd....

  14. Raman spectroscopy of optical properties in CdS thin films

    Directory of Open Access Journals (Sweden)

    Trajić J.

    2015-01-01

    Full Text Available Properties of CdS thin films were investigated applying atomic force microscopy (AFM and Raman spectroscopy. CdS thin films were prepared by using thermal evaporation technique under base pressure 2 x 10-5 torr. The quality of these films was investigated by AFM spectroscopy. We apply Raman scattering to investigate optical properties of CdS thin films, and reveal existence of surface optical phonon (SOP mode at 297 cm-1. Effective permittivity of mixture were modeled by Maxwell - Garnet approximation. [Projekat Ministarstva nauke Republike Srbije, br. 45003

  15. IL-2 and IL-15 regulate CD154 expression on activated CD4 T cells

    DEFF Research Database (Denmark)

    Skov, S; Bonyhadi, M; Odum, Niels

    2000-01-01

    The cellular and humoral immune system is critically dependent upon CD40-CD154 (CD40 ligand) interactions between CD40 expressed on B cells, macrophages, and dendritic cells, and CD154 expressed primarily on CD4 T cells. Previous studies have shown that CD154 is transiently expressed on CD4 T cells...... after T cell receptor engagement in vitro. However, we found that stimulation of PBLs with maximal CD28 costimulation, using beads coupled to Abs against CD3 and CD28, led to a very prolonged expression of CD154 on CD4 cells (>4 days) that was dependent upon autocrine IL-2 production. Previously...... activated CD4 T cells could respond to IL-2, or the related cytokine IL-15, by de novo CD154 production and expression without requiring an additional signal from CD3 and CD28. These results provide evidence that CD28 costimulation of CD4 T cells, through autocrine IL-2 production, maintains high levels...

  16. Studies in CdSe/CdS nanophosphors

    International Nuclear Information System (INIS)

    Chander, Harish

    2006-01-01

    Nanophosphors, also known as quantum dots, are being studied vigorously as these show enhanced efficiency and performance with great potential for tailoring properties. Nano size of these materials is responsible for opening novel applications everyday. Thin film light emitting devices, high definition TV, non-linear optical devices, ultra sensitive detectors and new white light sources are just few to mention. A lot of effort is being put in for using nanophosphors as fluorescent labels in biological applications. Many nanophosphors (quantum dots - QDs) of CdSe, CdS and combinations thereof exhibiting very high quality have been synthesised and studied. Quantum yield as high as 85% and a peaked emission have been reported. The potential of these materials has convinced the world that future belongs to them and serious attention needs to be diverted in research and development of these. In the present work, an attempt is made to review important studies made in the field of CdS/CdSe based nanophosphors with significant observations and results. Various upcoming applications of the family are highlighted. (author)

  17. Annelids. A Multimedia CD-ROM. [CD-ROM].

    Science.gov (United States)

    2001

    This CD-ROM is designed for classroom and individual use to teach and learn about annelids. Integrated animations, custom graphics, three-dimensional representations, photographs, and sound are featured for use in user-controlled activities. Interactive lessons are available to reinforce the subject material. Pre- and post-testing sections are…

  18. Is applying the same exercise-based inpatient program to normal and reduced left ventricular function patients the best strategy after coronary surgery? A focus on autonomic cardiac response.

    Science.gov (United States)

    Mendes, Renata Gonçalves; Simões, Rodrigo Polaquini; Costa, Fernando de Souza Melo; Pantoni, Camila Bianca Falasco; Di Thommazo-Luporini, Luciana; Luzzi, Sérgio; Amaral-Neto, Othon; Arena, Ross; Catai, Aparecida Maria; Borghi-Silva, Audrey

    2014-01-01

    To assess whether the same exercise-based inpatient program applied to patients with normal and reduced left ventricular function (LVF) evokes a similar cardiac autonomic response after coronary artery bypass graft (CABG). Forty-four patients post-CABG, subgrouped according to normal LVF [LVFN: n = 23; left ventricular ejection fraction (LVEF) ≥ 55%] and reduced LVF (LVFR: n = 21; LVEF 35-54%), were included. All initiated the exercise protocol on post-operative day 1 (PO1), following a whole progressive program until discharge. Cardiac autonomic response was assessed by the indices of heart rate variability (HRV) at rest and during exercise (extremity range of motion and ambulation). During ambulation, lower values of HRV indices were found in the LVFR group compared with the LVFN group [standard deviation of all RR (STDRR; 6.1 ± 2.7 versus 8.9 ± 4.7 ms), baseline width of the RR histogram (TINN; 30.6 ± 14.8 versus 45.8 ± 24.9 ms), SD2 (14.8 ± 8.0 versus 21.3 ± 9.0 ms), Shannon entropy (3.6 ± 0.5 versus 3.9 ± 0.4) and correlation dimension (0.08 ± 0.2 versus 0.2 ± 0.2)]. Also, when comparing the ambulation to rest change, lower values were observed in the LVFR group for linear (STDRR, TINN, RR TRI, rMSSD) and non-linear (SD2 and correlation dimension) HRV indices (p exercise (extremity range of motion), for mean intervals between heart beats and heart rate. For patients with LVFN, the same inpatient exercise protocol triggered a more attenuated autonomic response compared with patients with LVFR. These findings have implications as to how exercise should be prescribed according to LVF in the early stages following recovery from CABG. Implications for Rehabilitation Exercise-based inpatient program, performed by post-CABG patients who have normal left ventricular function, triggered a more attenuated cardiac autonomic response compared with patients with reduced left ventricular function. Volume of the inpatient exercises should be prescribed according

  19. HIV-specific cytotoxic T lymphocyte precursors exist in a CD28-CD8+ T cell subset and increase with loss of CD4 T cells.

    Science.gov (United States)

    Lewis, D E; Yang, L; Luo, W; Wang, X; Rodgers, J R

    1999-06-18

    To determine whether the CD28-CD8+ T cells that develop during HIV infection contain HIV-specific cytotoxic precursor cells. CD8 subpopulations from six asymptomatic HIV-positive adults, with varying degrees of CD4 T cell loss, were sorted by flow cytometry and HIV-specific precursor cytotoxic T lymphocyte frequencies were measured. Three populations of CD8 T cells were tested: CD28+CD5-- T cells, CD28-CD57+ T cells (thought to be memory cells) and CD28-CD57- T cells (function unknown). Sorted CD8 subsets were stimulated with antigen presenting cells expressing HIV-1 Gag/Pol molecules. Cytotoxic T cell assays on Gag/Pol expressing 51Cr-labeled Epstein-Barr virus transformed autologous B cells lines or control targets were performed after 2 weeks. Specific lysis and precursor frequencies were calculated. Both CD28 positive and CD28-CD57+ populations contained appreciable numbers of precursors (9-1720 per 10(6) CD8+ T cells). However, the CD28-CD57- population had fewer precursors in five out of six people studied. More CD28 positive HIV-specific cytotoxic T lymphocyte precursors were found in patients with CD4:CD8 ratios > 1, whereas more CD28-CD57+ precursors were found in patients whose CD4:CD8 ratios were < 1 (r2, 0.68). Memory HIV-specific precursor cytotoxic T lymphocytes are found in both CD28 positive and CD28-CD8+ cells, however, a CD28-CD57- subpopulation had fewer. Because CD28-CD57+ cells are antigen-driven with limited diversity, the loss of CD28 on CD8 T cells during disease progression may reduce the response to new HIV mutations; this requires further testing.

  20. My Teacher got a Trip to Kitt Peak Observatory, but all I got was This Lousy Data CD: Lessons Learned in Optimizing a Teacher Professional Development Program for Solar Research

    Science.gov (United States)

    Walker, C. E.; Hill, F.; Plymate, C.

    2005-12-01

    The solar project in "Teacher Leaders in Research-Based Science Education" program provides the opportunity for teachers to study the Sun with the world's largest solar telescope. This exciting program is designed for middle and high school science teachers with more than 5 years experience teaching science. Funded by a National Science Foundation (NSF) Teacher Retention and Renewal grant, teachers learn how to acquire astronomy data and support their students in conducting authentic astronomy research projects. In addition, the program enhances their skills as leaders and mentors for those science teachers new to the profession. The TLRBSE program includes: 1) A 14-week online distance learning program with an emphasis on spectroscopy and data imaging; 2) A 2-week in-residence workshop at the National Optical Astronomy Observatory in Tucson, including several nights of research observing at a world-class observatory; 3) A program of ongoing mentoring support for beginning teachers; and 4) Partial funding to attend a national NSTA meeting with the mentees; 5) A journal to publish student and teacher research results and 6) Access to ongoing research, via further observing runs or archival data. Various factors have played a part in the evolution of the solar project. It began as an activity that used sunspots to measure the solar rotation rate. Then it progressed to a comparison of active regions (e.g., the areas of sunspots) at various wavelengths, to measuring the splitting of infrared spectral lines due to strong magnetic fields in active regions, and to measuring the amount of polarization due to weak magnetic fields. Challenges were presented as the project evolved from an activity to a hands-on observing experience fully reflecting the scientific research process. Some of the issues and trade-offs we will discuss are hands-on observing experience vs. remote observing, archival data retrieval vs. talking data, and more vs. less scientific assistance in the