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Sample records for cbf mapping insight

  1. [Xenon CT CBF mapping derived from two minutes inhalation].

    Science.gov (United States)

    Toshima, R; Toyohara, K; Ebisawa, T; Ishikawa, K; Karashima, H; Shimojo, S; Miyahara, T

    1988-04-01

    Although xenon enhanced CT method for local cerebral blood flow measurement has been brought into a clinical practice, the technique has inherent limitations including anesthetic effects and expensive cost of xenon by a large consumption. To overcome these problems a modified method with a short-duration inhalation was developed and its validity was attested. Siemens Somatom SF with a resolution of 256 X 256 pixels and a scan time of 10 seconds was used. The subjects inhaled 50% Xe/O2 gas mixture from an apparatus consisted of Douglas bag and an open circuit. Xenon concentration in the expired gas was continuously monitored and estimated for arterial blood concentration by using a hematocrit correction. PaCO2 was monitored throughout the study. At the starting point and the endpoint of the inhalation two scans were performed respectively. Thus obtained four images were processed for CT noise cancellation, summation and subtraction to produce an in vivo autoradiography image. Local CBF was calculated from equations derived from the autoradiographic technique with a fixed partition coefficient of lambda = 1. Computer simulation studies were performed to find the optimal scan point to obtain an autoradiographic image and to estimate the calculation errors of this method. One minute and forty-five seconds was found to be the optimal scan point to gain an autoradiographic image in view of a balance between linearity of CBF/enhancement curve and total amount of tissue enhancement. The theoretical errors due to the assumption for a fixed partition coefficient were calculated to be 8% underestimation for gray matter and 5% overestimation for white matter.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:3401410

  2. Brain regions involved in voluntary movements as revealed by radioisotopic mapping of CBF or CMR-glucose changes

    DEFF Research Database (Denmark)

    Lassen, N A; Ingvar, D H

    1990-01-01

    Mapping of cortical and subcortical grey matter active during voluntary movements by means of measurements of local increases of CBF or CMR-Glucose is reviewed. Most of the studies concern observations in man during hand movements using the intracarotid Xenon-133 injection technique, an approach...... area SMA on both sides increase in CBF/CMR-glucose and even internally ("mentally") going through the trained movements, causes such changes; complex purposeful movements also activate the premotor cortex, a response that is bilateral with greatest response contralaterally. Studies in patients...

  3. Copy number variation at the HvCBF4-HvCBF2 genomic segment is a major component of frost resistance in barley.

    Science.gov (United States)

    Francia, Enrico; Morcia, Caterina; Pasquariello, Marianna; Mazzamurro, Valentina; Milc, Justyna Anna; Rizza, Fulvia; Terzi, Valeria; Pecchioni, Nicola

    2016-09-01

    A family of CBF transcription factors plays a major role in reconfiguring the plant transcriptome in response to low-freezing temperature in temperate cereals. In barley, more than 13 HvCBF genes map coincident with the major QTL FR-H2 suggesting them as candidates to explain the function of the locus. Variation in copy number (CNV) of specific HvCBFs was assayed in a panel of 41 barley genotypes using RT-qPCR. Taking advantage of an accurate phenotyping that combined Fv/Fm and field survival, resistance-associated variants within FR-H2 were identified. Genotypes with an increased copy number of HvCBF4 and HvCBF2 (at least ten and eight copies, respectively) showed greater frost resistance. A CAPS marker able to distinguish the CBF2A, CBF2B and CBF2A/B forms was developed and showed that all the higher-ranking genotypes in term of resistance harbour only CBF2A, while other resistant winter genotypes harbour also CBF2B, although at a lower CNV. In addition to the major involvement of the HvCBF4-HvCBF2 genomic segment in the proximal cluster of CBF elements, a negative role of HvCBF3 in the distal cluster was identified. Multiple linear regression models taking into account allelic variation at FR-H1/VRN-H1 explained 0.434 and 0.550 (both at p < 0.001) of the phenotypic variation for Fv/Fm and field survival respectively, while no interaction effect between CNV at the HvCBFs and FR-H1/VRN-H1 was found. Altogether our data suggest a major involvement of the CBF genes located in the proximal cluster, with no apparent involvement of the central cluster contrary to what was reported for wheat. PMID:27338258

  4. Copy number variation at the HvCBF4-HvCBF2 genomic segment is a major component of frost resistance in barley.

    Science.gov (United States)

    Francia, Enrico; Morcia, Caterina; Pasquariello, Marianna; Mazzamurro, Valentina; Milc, Justyna Anna; Rizza, Fulvia; Terzi, Valeria; Pecchioni, Nicola

    2016-09-01

    A family of CBF transcription factors plays a major role in reconfiguring the plant transcriptome in response to low-freezing temperature in temperate cereals. In barley, more than 13 HvCBF genes map coincident with the major QTL FR-H2 suggesting them as candidates to explain the function of the locus. Variation in copy number (CNV) of specific HvCBFs was assayed in a panel of 41 barley genotypes using RT-qPCR. Taking advantage of an accurate phenotyping that combined Fv/Fm and field survival, resistance-associated variants within FR-H2 were identified. Genotypes with an increased copy number of HvCBF4 and HvCBF2 (at least ten and eight copies, respectively) showed greater frost resistance. A CAPS marker able to distinguish the CBF2A, CBF2B and CBF2A/B forms was developed and showed that all the higher-ranking genotypes in term of resistance harbour only CBF2A, while other resistant winter genotypes harbour also CBF2B, although at a lower CNV. In addition to the major involvement of the HvCBF4-HvCBF2 genomic segment in the proximal cluster of CBF elements, a negative role of HvCBF3 in the distal cluster was identified. Multiple linear regression models taking into account allelic variation at FR-H1/VRN-H1 explained 0.434 and 0.550 (both at p < 0.001) of the phenotypic variation for Fv/Fm and field survival respectively, while no interaction effect between CNV at the HvCBFs and FR-H1/VRN-H1 was found. Altogether our data suggest a major involvement of the CBF genes located in the proximal cluster, with no apparent involvement of the central cluster contrary to what was reported for wheat.

  5. Reassessing the clinical efficacy of two MR quantitative DSC PWI CBF algorithms following cross-calibration with PET images

    Science.gov (United States)

    Chen, Jean J.; Frayne, Richard; Smith, Michael R.

    2005-03-01

    Clinical cerebral blood flow (CBF) maps generated through dynamic- susceptibility contrast (DSC) magnetic resonance (MR) perfusion imaging are currently cross-calibrated with PET studies. The cross-calibration is achieved by rescaling the MR CBF values so that normal white matter CBF corresponds to 22 ml/100 g/min. Examples are provided in this paper to show how this rescaling procedure changes both the clinical interpretation of CBF maps and the manner by which the performance of a given deconvolution algorithm should be assessed. (i) Singular-value decomposition-based (SVD) algorithms produce absolute CBF estimates that are inherently under-estimated for all tissue mean transit times (MTT) but, after rescaling, will generate CBF maps that are over-estimated for MTT >4.8 s. (ii) In principle, frequency-domain modelling techniques are expected to be inherently less sensitive to contrast recirculation biases than the time-domain SVD algorithms. However, it is shown that both CBF algorithms become greatly less sensitive to distortions from recirculation after clinical cross-calibration through rescaling has been performed. It is concluded that, when rescaling procedures are employed, it is relatively more important to develop deconvolution algorithms that produce CBF estimates with accuracies that vary little with MTT than to produce algorithms that provide inherently more accurate CBF estimates, but whose relative accuracy varies significantly with MTT. A portion of this work was presented at the 2004 Annual Scientific Meeting of the ISMRM, 15-21 May, Kyoto, Japan.

  6. Memory-provoked rCBF-SPECT as a diagnostic tool in Alzheimer's disease?

    International Nuclear Information System (INIS)

    Alzheimer's disease (AD) is a primary degenerative disease that progressively affects all brain functions, with devastating consequences for the patient, the patient's family and society. Rest regional cerebral blood flow (rCBF) could have a strategic role in differentiating between AD patients and normal controls, but its use for this purpose has a low discriminatory capacity. The purpose of this study was to evaluate whether the diagnostic sensitivity of rCBF single-photon emission computed tomography (SPECT) could be increased by using an episodic memory task provocation, i.e. memory-provoked rCBF-SPECT (MP-SPECT). Eighteen persons (73.2±4.8 years) with mild AD and 18 healthy elderly (69.4±3.9 years) were included in the study. The subjects were injected with99mTc-hexamethylpropylene amine oxime (HMPAO) during memory provocation with faces and names, followed by an rCBF-SPECT study. The rCBF99mTc-HMPAO SPECT images were analysed using statistical parametric mapping (SPM2). Peaks with a false discovery rate corrected value of 0.05 were considered significant. On MP-SPECT, the AD group showed a significant rCBF reduction in the left parietal cortex in comparison with healthy elderly. At rest, no significant group differences were seen. Memory provocation increased the sensitivity of rCBF-SPECT for the detection of AD-related blood flow changes in the brain at the group level. Further studies are needed to evaluate MP-SPECT as a diagnostic tool at the individual level. If a higher sensitivity for AD at the individual level is verified in future studies, a single MP-SPECT study might be sufficient in the clinical setting. (orig.)

  7. Gaining insight in domestic violence with emergent self organizing maps

    NARCIS (Netherlands)

    J. Poelmans; P. Elzinga; S. Viaene; M.M. van Hulle; G. Dedene

    2009-01-01

    Topographic maps are an appealing exploratory instrument for discovering new knowledge from databases. During the past years, new types of Self Organizing Maps (SOM) were introduced in the literature, including the recent Emergent SOM. The ESOM tool is used here to analyze a large set of police repo

  8. Insights from probability distribution functions of intensity maps

    CERN Document Server

    Breysse, Patrick C; Behroozi, Peter S; Dai, Liang; Kamionkowski, Marc

    2016-01-01

    In the next few years, intensity-mapping surveys that target lines such as CO, Ly$\\alpha$, and CII stand to provide powerful probes of high-redshift astrophysics. However, these line emissions are highly non-Gaussian, and so the typical power-spectrum methods used to study these maps will leave out a significant amount of information. We propose a new statistic, the probability distribution of voxel intensities, which can access this extra information. Using a model of a CO intensity map at $z\\sim3$ as an example, we demonstrate that this voxel intensity distribution (VID) provides substantial constraining power beyond what is obtainable from the power spectrum alone. We find that a future survey similar to the planned COMAP Full experiment could constrain the CO luminosity function to order $\\sim10\\%$. We also explore the effects of contamination from continuum emission, interloper lines, and gravitational lensing on our constraints and find that the VID statistic retains significant constraining power even ...

  9. Statistic rCBF study of extrapyramidal disorders

    Energy Technology Data Exchange (ETDEWEB)

    Kamei, Hiroshi; Nakajima, Takashi; Fukuhara, Nobuyoshi [National Saigata Hospital, Ogata, Niigata (Japan)

    2002-08-01

    We studied regional cerebral blood flow (rCBF) in 16 patients with Parkinson's disease (PD), 2 patients with dementia with Lewy bodies (DLB), 2 patients with progressive supranuclear palsy (PSP), 2 patients with striatonigral degeneration, and 16 normal volunteers, using Three-dimensional stereotactic surface projections (3D-SSP). Decreased rCBF in PD patients was shown in the posterior parietal and occipital cortex. Decreased rCBF in DLB was shown in the frontal, parietal and occipital cortex with relative sparing of the sensorimotor cortex.. Decreased rCBF in PSP was shown in the frontal cortex. Decreased rCBF in SND was shown in the frontal cortex and cerebellum. Statistic rCBF analysis using 3D-SSP was a useful measure for the early differential diagnosis of extrapyramidal disorders. (author)

  10. Volcanism on Io: New insights from global geologic mapping

    Science.gov (United States)

    Williams, D.A.; Keszthelyi, L.P.; Crown, D.A.; Yff, J.A.; Jaeger, W.L.; Schenk, P.M.; Geissler, P.E.; Becker, T.L.

    2011-01-01

    We produced the first complete, 1:15M-scale global geologic map of Jupiter's moon Io, based on a set of monochrome and color Galileo-Voyager image mosaics produced at a spatial resolution of 1km/pixel. The surface of Io was mapped into 19 units based on albedo, color and surface morphology, and is subdivided as follows: plains (65.8% of surface), lava flow fields (28.5%), mountains (3.2%), and patera floors (2.5%). Diffuse deposits (DD) that mantle the other units cover ???18% of Io's surface, and are distributed as follows: red (8.6% of surface), white (6.9%), yellow (2.1%), black (0.6%), and green (???0.01%). Analyses of the geographical and areal distribution of these units yield a number of results, summarized below. (1) The distribution of plains units of different colors is generally geographically constrained: Red-brown plains occur >??30?? latitude, and are thought to result from enhanced alteration of other units induced by radiation coming in from the poles. White plains (possibly dominated by SO2+contaminants) occur mostly in the equatorial antijovian region (??30??, 90-230??W), possibly indicative of a regional cold trap. Outliers of white, yellow, and red-brown plains in other regions may result from long-term accumulation of white, yellow, and red diffuse deposits, respectively. (2) Bright (possibly sulfur-rich) flow fields make up 30% more lava flow fields than dark (presumably silicate) flows (56.5% vs. 43.5%), and only 18% of bright flow fields occur within 10km of dark flow fields. These results suggest that secondary sulfurous volcanism (where a bright-dark association is expected) could be responsible for only a fraction of Io's recent bright flows, and that primary sulfur-rich effusions could be an important component of Io's recent volcanism. An unusual concentration of bright flows at ???45-75??N, ???60-120??W could be indicative of more extensive primary sulfurous volcanism in the recent past. However, it remains unclear whether most bright

  11. Identification,characterization and expression analysis of transcription factor (CBF) genes in rice (Oryza sativa L.)

    Institute of Scientific and Technical Information of China (English)

    Yunfei CAO; Jiaojiao WANG; Li GUO; Kai XIAO

    2008-01-01

    The acclimation of plants to cold,salt and dehydration is involved in the action of the transcription factor (CBF) cold-response pathway.In this paper,nineteen rice CBF genes,including seven previously released and twelve unpublished novels,were identified and characterized.The multi-members of rice CBFs (OsCBF1 to OsCBF12) were divergent at the nucleotide and amino acid level.Expression analysis shows that five novel rice CBF genes (OsCBF1,OsCBF2,OsCBF3,OsCBF8,and OsCBF9) responded to short-term (1 h or 3 h) stresses of low temperature,salt stress and dehydration.The transcripts of OsCBF2,OsCBF8 and OsCBF9 in the roots were rapidly elevated when the plants were exposed to low temperatures,suggesting that they were possibly involved in low temperature responses in rice plants.Meanwhile,the expression level of OsCBF2 in leaves was enhanced when exposed to salt stress of 1-3 h,implying that OsCBF2 functioned as a transduction component in the salt stress signal cascade.Various expression patterns in OsCBF1,OsCBF2,OsCBF3,OsCBF8,and OsCBF9 under low temperature,salt and drought conditions,together with the different expression patterns between roots and leaves for each of these indicated that every rice CBF gene has unique and non-redundant functions in the response to the abiotic stresses.

  12. Maps and Masses of Transiting Exoplanets: Towards New Insights into Atmospheric and Interior Properties of Planets

    CERN Document Server

    de Wit, Julien

    2015-01-01

    With over 1800 planets discovered outside of the Solar System in the past two decades, the field of exoplanetology has broadened our perspective on planetary systems. Research priorities are now moving from planet detection to planet characterization. In this context, transiting exoplanets are of special interest due to the wealth of data made available by their orbital configuration. Here, I introduce two methods to gain new insights into the atmospheric and interior properties of exoplanets. The first method aims to map an exoplanet's atmosphere based on the scanning obtained while it is occulted by its host star. I introduce the basics of eclipse mapping, its caveats, and a framework to mitigate their effects via global analyses including transits, phase curves, and radial velocity measurements. I use this method to create the first 2D map and the first cloud map of an exoplanet for the hot-Jupiters HD189733b and Kepler-7b, respectively. Ultimately temperature, composition, and circulation patterns could b...

  13. Simultaneous Imaging of CBF Change and BOLD with Saturation-Recovery-T1 Method.

    Science.gov (United States)

    Wang, Xiao; Zhu, Xiao-Hong; Zhang, Yi; Chen, Wei

    2015-01-01

    A neuroimaging technique based on the saturation-recovery (SR)-T1 MRI method was applied for simultaneously imaging blood oxygenation level dependence (BOLD) contrast and cerebral blood flow change (ΔCBF), which is determined by CBF-sensitive T1 relaxation rate change (ΔR1CBF). This technique was validated by quantitatively examining the relationships among ΔR1CBF, ΔCBF, BOLD and relative CBF change (rCBF), which was simultaneously measured by laser Doppler flowmetry under global ischemia and hypercapnia conditions, respectively, in the rat brain. It was found that during ischemia, BOLD decreased 23.1±2.8% in the cortical area; ΔR1CBF decreased 0.020±0.004s-1 corresponding to a ΔCBF decrease of 1.07±0.24 ml/g/min and 89.5±1.8% CBF reduction (n=5), resulting in a baseline CBF value (=1.18 ml/g/min) consistent with the literature reports. The CBF change quantification based on temperature corrected ΔR1CBF had a better accuracy than apparent R1 change (ΔR1app); nevertheless, ΔR1app without temperature correction still provides a good approximation for quantifying CBF change since perfusion dominates the evolution of the longitudinal relaxation rate (R1app). In contrast to the excellent consistency between ΔCBF and rCBF measured during and after ischemia, the BOLD change during the post-ischemia period was temporally disassociated with ΔCBF, indicating distinct CBF and BOLD responses. Similar results were also observed for the hypercapnia study. The overall results demonstrate that the SR-T1 MRI method is effective for noninvasive and quantitative imaging of both ΔCBF and BOLD associated with physiological and/or pathological changes.

  14. Simultaneous Imaging of CBF Change and BOLD with Saturation-Recovery-T1 Method.

    Directory of Open Access Journals (Sweden)

    Xiao Wang

    Full Text Available A neuroimaging technique based on the saturation-recovery (SR-T1 MRI method was applied for simultaneously imaging blood oxygenation level dependence (BOLD contrast and cerebral blood flow change (ΔCBF, which is determined by CBF-sensitive T1 relaxation rate change (ΔR1CBF. This technique was validated by quantitatively examining the relationships among ΔR1CBF, ΔCBF, BOLD and relative CBF change (rCBF, which was simultaneously measured by laser Doppler flowmetry under global ischemia and hypercapnia conditions, respectively, in the rat brain. It was found that during ischemia, BOLD decreased 23.1±2.8% in the cortical area; ΔR1CBF decreased 0.020±0.004s-1 corresponding to a ΔCBF decrease of 1.07±0.24 ml/g/min and 89.5±1.8% CBF reduction (n=5, resulting in a baseline CBF value (=1.18 ml/g/min consistent with the literature reports. The CBF change quantification based on temperature corrected ΔR1CBF had a better accuracy than apparent R1 change (ΔR1app; nevertheless, ΔR1app without temperature correction still provides a good approximation for quantifying CBF change since perfusion dominates the evolution of the longitudinal relaxation rate (R1app. In contrast to the excellent consistency between ΔCBF and rCBF measured during and after ischemia, the BOLD change during the post-ischemia period was temporally disassociated with ΔCBF, indicating distinct CBF and BOLD responses. Similar results were also observed for the hypercapnia study. The overall results demonstrate that the SR-T1 MRI method is effective for noninvasive and quantitative imaging of both ΔCBF and BOLD associated with physiological and/or pathological changes.

  15. Calcite sealing in a fractured geothermal reservoir: Insights from combined EBSD and chemistry mapping

    Science.gov (United States)

    McNamara, David D.; Lister, Aaron; Prior, Dave J.

    2016-09-01

    Fractures play an important role as fluid flow pathways in geothermal resources hosted in indurated greywacke basement of the Taupo Volcanic Zone, New Zealand, including the Kawerau Geothermal Field. Over time, the permeability of such geothermal reservoirs can be degraded by fracture sealing as minerals deposit out of transported geothermal fluids. Calcite is one such fracture sealing mineral. This study, for the first time, utilises combined data from electron backscatter diffraction and chemical mapping to characterise calcite vein fill morphologies, and gain insight into the mechanisms of calcite fracture sealing in the Kawerau Geothermal Field. Two calcite sealing mechanisms are identified 1) asymmetrical syntaxial growth of calcite, inferred by the presence of single, twinned, calcite crystals spanning the entire fracture width, and 2) 3D, interlocking growth of bladed vein calcite into free space as determined from chemical and crystallographic orientation mapping. This study also identifies other potential uses of combined EBSD and chemical mapping to understand geothermal field evolution including, potentially informing on levels of fluid supersaturation from the study of calcite lattice distortion, and providing information on a reservoir's history of stress, strain, and deformation through investigation of calcite crystal deformation and twinning patterns.

  16. Normal pressure hydrocephalus, (1). Pre- and post-operative r-CBF

    Energy Technology Data Exchange (ETDEWEB)

    Kusunoki, T.; Kose, S.; Noda, S.; Tamaki, N.; Matsumoto, S. (Kobe Univ. (Japan). School of Medicine); Yamashita, H.

    1982-06-01

    Pre-and post-operative r-CBF was examined with the /sup 133/Xe inhalation method in 11 patients of normal pressure hydrocephalus (NPH). In the effective shunt group consisting of 8 patients, the preoperative mean hemispheric CBF was slightly lower than normal, while depression of the r-CBF in the frontal and parietal lobes was considerable. However, in the non-effective shunt group consisting of 3 patients, the preoperative mean hemispheric CBF was significantly lower than normal, and the r-CBF in the frontal, parietal and temporal lobes was consistantly low. In the effective shunt group, about a 10% increase in the postoperative mean hemispheric CBF was noticed and the increased r-CBF was more prominent in the frontal and parietal lobes. However, the postoperative CBF did not increase in the non-effective shunt group. Improvement of symptoms did not always parallel the postoperatively increased mean hemispheric CBF. The possibility of predicting shunt effectiveness from the features of preoperative r-CBF study in NPH, the mechanism of the postoperative change in CBF, and the necessity of pathogenetic diagnosis of NPH for the evaluation of pre- and post-operative CBF study were discusses.

  17. A simplified method of xenon-enhanced CT for regional cerebral blood flow (rCBF) measurement with reference to clinical experiences

    International Nuclear Information System (INIS)

    We introduced a simplified method of xenon-enhanced CT (SXe-CT) for obtaining the topographic regional cerebral blood flow (rCBF) map. In the SXe-CT, we used the method of brief (three to four minutes) inhalation of 40 % xenon. To shorten the period of xenon inhalation, we substituted a predetermined brain-blood partition coefficient (L) in the entire brain for the directly estimated L to calculate the rCBF value. Because of its non-invasiveness and simplicity, the SXe-CT can be applied to the patients with diseases in the central nervous system (CNS) without any difficulties. During the past three years, we performed the SXe-CT on 150 occasions in 100 subjects, including those with moyamoya disease, other ischemic cerebrovascular diseases, arteriovenous malformations and normal pressure hydrocephalus. In this paper, the rCBF values of seven normal healthy adults with a mean age of 24 years are reported and the flow maps of some cases of CNS diseases are presented. The normal mean value of the hemispheres was 53, those of the gray matter were in the range of 38 to 72, those of the white matter were in the range of 26 to 35 and those of the basal ganglia and thalamus were 55 to 88 (values are given in ml/100 g/min). The SXe-CT has potential advantages in obtaining clinically useful rCBF measurements. (author)

  18. Identification and characterization of CBF/DREB1-related genes in Populus hopeiensis

    Institute of Scientific and Technical Information of China (English)

    WANG Ze-liang; AN Xin-min; LI Bo; REN Yuan-yuan; JIANG Xi-bing; BO Wen-hao; ZHANG Zhi-yi

    2008-01-01

    The dehydration-responsive element-binding factor (DREB) is a plant-specific family of transcription factors and plays an important role in plant response and adaptation to abiotic stress. In the present work, two highly similar CBF/DREBl-like genes, designated as PhCBF4a and PhCBF4b, were identified from Populus hopeiensis. These two genes contain all conserved domains known to exist in other CBF/DREBI genes. In the AP2 domain, there is only one different amino acid residue between PhCBF4a and PhCBF4b, alanine or valine, a nonpolar amino acid, suggesting that PhCBF4a and PhCBF4b may have similar DNA binding ability. Their expression is induced by water-loss treatment and their expression patterns axe similar. Moreover, with a genomic DNA as template, the presence of the same bands in PCR products as those in expression pattern analysis indicated that PhCBF4a and PhCBF4b exist in the genome of P. hopeiensis. Their detailed functions are discussed and will need further study.

  19. Comparison of peanut gentics and physical maps provided insights on collinearity, reversions and translocations

    Science.gov (United States)

    Genetic and physical maps are the valuable resources for peanut research community in understanding genome organization and serving as the basis for map-based cloning and marker-assisted selection. Physical maps of two diploid wild peanut progenitor species, Arachis duranensis (A genome) and A. ipae...

  20. Transcriptional profiling of Medicago truncatula under salt stress identified a novel CBF transcription factor MtCBF4 that plays an important role in abiotic stress responses

    Directory of Open Access Journals (Sweden)

    Su Zhen

    2011-07-01

    Full Text Available Abstract Background Salt stress hinders the growth of plants and reduces crop production worldwide. However, different plant species might possess different adaptive mechanisms to mitigate salt stress. We conducted a detailed pathway analysis of transcriptional dynamics in the roots of Medicago truncatula seedlings under salt stress and selected a transcription factor gene, MtCBF4, for experimental validation. Results A microarray experiment was conducted using root samples collected 6, 24, and 48 h after application of 180 mM NaCl. Analysis of 11 statistically significant expression profiles revealed different behaviors between primary and secondary metabolism pathways in response to external stress. Secondary metabolism that helps to maintain osmotic balance was induced. One of the highly induced transcription factor genes was successfully cloned, and was named MtCBF4. Phylogenetic analysis revealed that MtCBF4, which belongs to the AP2-EREBP transcription factor family, is a novel member of the CBF transcription factor in M. truncatula. MtCBF4 is shown to be a nuclear-localized protein. Expression of MtCBF4 in M. truncatula was induced by most of the abiotic stresses, including salt, drought, cold, and abscisic acid, suggesting crosstalk between these abiotic stresses. Transgenic Arabidopsis over-expressing MtCBF4 enhanced tolerance to drought and salt stress, and activated expression of downstream genes that contain DRE elements. Over-expression of MtCBF4 in M. truncatula also enhanced salt tolerance and induced expression level of corresponding downstream genes. Conclusion Comprehensive transcriptomic analysis revealed complex mechanisms exist in plants in response to salt stress. The novel transcription factor gene MtCBF4 identified here played an important role in response to abiotic stresses, indicating that it might be a good candidate gene for genetic improvement to produce stress-tolerant plants.

  1. Comparative evaluation of different methods for calculation of cerebral blood flow (CBF) in nonanesthetized rabbits

    International Nuclear Information System (INIS)

    The measurement of cerebral blood flow (CBF) by the extracranial detection of the radioactivity of 133Xe injected into an internal carotid artery has proved to be of considerable value for the investigation of cerebral circulation in conscious rabbits. Methods are described for calculating CBF from the curves of clearance of 133Xe, and include exponential analysis (two-component model), initial slope, and stochastic method. The different methods of curve analysis were compared in order to evaluate the fitness with the theoretical model. The initial slope and stochastic methods, compared with the biexponential model, underestimate the CBF by 35% and 46% respectively. Furthermore, the validity of recording the clearance curve for 10 min was tested by comparing these CBF values with those obtained from the whole curve. CBF values calculated with the shortened procedure are overestimated by 17%. A correlation exists between the ''10 min'' CBF values and the CBF calculated from the whole curve; in spite of that, the values are not accurate for limited animal populations or for single animals. The extent of the two main compartments into which the CBF is divided was also measured. There is no correlation between CBF values and the extent of the relative compartment. This fact suggests that these two parameters correspond to different biological entities

  2. The joys of mapping: qualitative insights into the student experience of a residential geoscience field course

    Science.gov (United States)

    Stokes, Alison

    2010-05-01

    Using a mixed-format survey instrument, Boyle et al. (2007) identify significant effects in the affective domain resulting from participation in residential fieldwork. These findings are echoed by Stokes & Boyle (2009) in a separate, more detailed, study into the experiences of geoscience students when learning geologic mapping. While providing a quantifiable measure of changes in the students' attitudes and feelings, however, these survey data provide limited information about the experiences that have resulted in these changes, or of the factors likely to have influenced them. In order to gain a deeper insight into the students' affective responses, the quantitative data collected during this study were supplemented with qualitative data from in-situ and group interviews, open (free-text) survey questions, and direct observation of fieldwork activities. This provided a richness and depth of information that could not be achieved from quantitative data alone, and thus afforded a greater understanding of the students' experiences of this particular field activity. The survey findings showed that positive feelings and attitudes present at the start of the mapping field course became reinforced, but closer scrutiny of the data revealed that over half of the student cohort (57%) embarked on the fieldwork with some degree of worry, concern, or anxiety. The qualitative data enabled the source of these negative feelings to be identified, and provided evidence that these were overcome as a result of participating in the fieldwork. Thematic content analysis of the data resulted in the emergence of ten major themes; these provided a clear indication of factors significant to the student experience, and of specific aspects of the field course likely to generate either positive or negative affective responses. Further, these data highlighted the complexity of the learning process, and demonstrated the extent to which experiences varied between individual students. The social

  3. Alpha-contingent EEG feedback reduces SPECT rCBF variability

    DEFF Research Database (Denmark)

    McLaughlin, Thomas; Steinberg, Bruce; Mulholland, Thomas;

    2005-01-01

    EEG feedback methods, which link the occurrence of alpha to the presentation of repeated visual stimuli, reduce the relative variability of subsequent, alpha-blocking event durations. The temporal association between electro-cortical field activation and regional cerebral blood flow (rCBF) led us...... to investigate whether the reduced variability of alpha-blocking durations with feedback is associated with a reduction in rCBF variability. Reduced variability in the rCBF response domain under EEG feedback control might have methodological implications for future brain-imaging studies. Visual stimuli were...... to quantify the variance-reducing effects of ACS across multiple, distributed areas of the brain. Both EEG and rCBF measures demonstrated decreased variability under ACS. This improved control was seen for localized as well as anatomically distributed rCBF measures....

  4. Isolation and characterization of a cDNA encoding a CBF transcription factor from E. globulus.

    Science.gov (United States)

    Gamboa, Maria C; Rasmussen-Poblete, Susana; Valenzuela, Pablo D T; Krauskopf, Erwin

    2007-01-01

    The transcription factors CBF/DREB play an important role during low temperature, drought and high-salt stress in higher plants. In this work, we isolated one full-length CBF cDNA clone from the angiosperm Eucalyptus globulus. The derived peptide sequence reveals that it encodes a transcriptional activator that has all the characteristic motifs present in CBF proteins previously described in Arabidopsis and tomato. RT-PCR analysis shows that EgCBF1 is transiently induced in E. globulus seedlings that had been exposed to low temperature within the first 15 min. These results suggest that the isolated CBF gene participates in the cold responsive pathway of E. globulus.

  5. Assessment of cerebral blood flow autoregulation (CBF AR) with rheoencephalography (REG): studies in animals

    International Nuclear Information System (INIS)

    The ability of cerebral vasculature to regulate cerebral blood flow (CBF) in the face of changes in arterial blood pressure (SAP) or intracranial pressure (ICP) is an important guard against secondary ischemia in acute brain injuries, and official guidelines recommend that therapeutic decisions be guided by continuous monitoring of CBF autoregulation (AR). The common method for CBF AR monitoring, which rests on real-time derivation of the correlation coefficient (PRx) between slow oscillations in SAP and ICP is, however, rarely used in clinical practice because it requires invasive ICP measurements. This study investigated whether the correlation coefficient between SAP and the pulsatile component of the non-invasive transcranial bioimpedance signal (rheoencephalography, REG) could be used to assess the state and lower limit of CBF AR. The results from pigs and rhesus macaques affirm the utility of REG; however, additional animal and clinical studies are warranted to assess selectivity of automatic REG-based evaluation of CBF AR.

  6. Assessment of cerebral blood flow autoregulation (CBF AR) with rheoencephalography (REG): studies in animals

    Science.gov (United States)

    Popovic, Djordje; Bodo, Michael; Pearce, Frederick; van Albert, Stephen; Garcia, Alison; Settle, Tim; Armonda, Rocco

    2013-04-01

    The ability of cerebral vasculature to regulate cerebral blood flow (CBF) in the face of changes in arterial blood pressure (SAP) or intracranial pressure (ICP) is an important guard against secondary ischemia in acute brain injuries, and official guidelines recommend that therapeutic decisions be guided by continuous monitoring of CBF autoregulation (AR). The common method for CBF AR monitoring, which rests on real-time derivation of the correlation coefficient (PRx) between slow oscillations in SAP and ICP is, however, rarely used in clinical practice because it requires invasive ICP measurements. This study investigated whether the correlation coefficient between SAP and the pulsatile component of the non-invasive transcranial bioimpedance signal (rheoencephalography, REG) could be used to assess the state and lower limit of CBF AR. The results from pigs and rhesus macaques affirm the utility of REG; however, additional animal and clinical studies are warranted to assess selectivity of automatic REG-based evaluation of CBF AR.

  7. Physical mapping and BAC-end sequence analysis provide initial insights into the flax (Linum usitatissimum L. genome

    Directory of Open Access Journals (Sweden)

    Cloutier Sylvie

    2011-05-01

    Full Text Available Abstract Background Flax (Linum usitatissimum L. is an important source of oil rich in omega-3 fatty acids, which have proven health benefits and utility as an industrial raw material. Flax seeds also contain lignans which are associated with reducing the risk of certain types of cancer. Its bast fibres have broad industrial applications. However, genomic tools needed for molecular breeding were non existent. Hence a project, Total Utilization Flax GENomics (TUFGEN was initiated. We report here the first genome-wide physical map of flax and the generation and analysis of BAC-end sequences (BES from 43,776 clones, providing initial insights into the genome. Results The physical map consists of 416 contigs spanning ~368 Mb, assembled from 32,025 fingerprints, representing roughly 54.5% to 99.4% of the estimated haploid genome (370-675 Mb. The N50 size of the contigs was estimated to be ~1,494 kb. The longest contig was ~5,562 kb comprising 437 clones. There were 96 contigs containing more than 100 clones. Approximately 54.6 Mb representing 8-14.8% of the genome was obtained from 80,337 BES. Annotation revealed that a large part of the genome consists of ribosomal DNA (~13.8%, followed by known transposable elements at 6.1%. Furthermore, ~7.4% of sequence was identified to harbour novel repeat elements. Homology searches against flax-ESTs and NCBI-ESTs suggested that ~5.6% of the transcriptome is unique to flax. A total of 4064 putative genomic SSRs were identified and are being developed as novel markers for their use in molecular breeding. Conclusion The first genome-wide physical map of flax constructed with BAC clones provides a framework for accessing target loci with economic importance for marker development and positional cloning. Analysis of the BES has provided insights into the uniqueness of the flax genome. Compared to other plant genomes, the proportion of rDNA was found to be very high whereas the proportion of known transposable

  8. Potential language and attentional networks revealed through factor analysis of rCBF data measured with SPECT

    DEFF Research Database (Denmark)

    McLaughlin, T; Steinberg, B; Christensen, B;

    1992-01-01

    We used changes in regional cerebral blood flow (rCBF) to disclose regions involved in central auditory and language processing in the normal brain. rCBF was quantified with a fast-rotating, single-photon emission computerized tomograph (SPECT) and inhalation of 133Xe. rCBF data were obtained sim...

  9. High-density interspecific genetic linkage mapping provides insights into genomic incompatibility between channel catfish and blue catfish.

    Science.gov (United States)

    Liu, S; Li, Y; Qin, Z; Geng, X; Bao, L; Kaltenboeck, L; Kucuktas, H; Dunham, R; Liu, Z

    2016-02-01

    Catfish is the leading aquaculture species in the United States. The interspecific hybrid catfish produced by mating female channel catfish with male blue catfish outperform both of their parent species in a number of traits. However, mass production of the hybrids has been difficult because of reproductive isolation. Investigations of genome structure and organization of the hybrids provide insights into the genetic basis for maintenance of species divergence in the face of gene flow, thereby helping develop strategies for introgression and efficient production of the hybrids for aquaculture. In this study, we constructed a high-density genetic linkage map using the hybrid catfish system with the catfish 250K SNP array. A total of 26,238 SNPs were mapped to 29 linkage groups, with 12,776 unique marker positions. The linkage map spans approximately 3240 cM with an average intermarker distance of 0.25 cM. A fraction of markers (986 of 12,776) exhibited significant deviation from the expected Mendelian ratio of segregation, and they were clustered in major genomic blocks across 15 LGs, most notably LG9 and LG15. The distorted markers exhibited significant bias for maternal alleles among the backcross progenies, suggesting strong selection against the blue catfish alleles. The clustering of distorted markers within genomic blocks should lend insights into speciation as marked by incompatibilities between the two species. Such findings should also have profound implications for understanding the genomic evolution of closely related species as well as the introgression of hybrid production programs in aquaculture.

  10. Establishing a leaf proteome reference map for Ginkgo biloba provides insight into potential ethnobotanical uses

    Science.gov (United States)

    Although ginkgo (Maidenhair tree, Ginkgo biloba L.) is an ancient medicinal and ornamental tree, there has not previously been any systematic proteomic study of the leaves. Herein we describe results from the initial study identifying abundant ginkgo leaf proteins and present a gel reference map. Pr...

  11. Mapping Communication along the Supply Chain in a Reputation-Sensitive Environment: Preliminary Insights

    OpenAIRE

    Mattia Giovanardi

    2014-01-01

    This exploratory qualitative study is aimed at depicting communication support to Supply Chain (SC) management, emphasizing how relationships and processes are affected by communication flows. It provides a preliminary comprehensive communication mapping, highlighting key stakeholders involved in SC management, communication roles enhancing logistics performances, and channels supporting information and physical flows among partners. It is based on a literature review, multidisciplinary acade...

  12. New insights into the geological structure of the Netherlands; results of a detailed mapping project

    NARCIS (Netherlands)

    Kombrink, H.; Doornenbal, J.C.; Duin, E.J.T.; Dulk, M. den; Gessel, S.F. van; Veen, J.H. ten; Witmans, N.

    2012-01-01

    A five years geological mapping project, in which the Netherlands Continental Shelf has been re-examined using all publicly available data, resulted in an important update of the existing dataset. The stratigraphy of over 400 wells has been re-interpreted. New depth and thickness grids, based mainly

  13. Abortive lytic reactivation of KSHV in CBF1/CSL deficient human B cell lines.

    Directory of Open Access Journals (Sweden)

    Barbara A Scholz

    Full Text Available Since Kaposi's sarcoma associated herpesvirus (KSHV establishes a persistent infection in human B cells, B cells are a critical compartment for viral pathogenesis. RTA, the replication and transcription activator of KSHV, can either directly bind to DNA or use cellular DNA binding factors including CBF1/CSL as DNA adaptors. In addition, the viral factors LANA1 and vIRF4 are known to bind to CBF1/CSL and modulate RTA activity. To analyze the contribution of CBF1/CSL to reactivation in human B cells, we have successfully infected DG75 and DG75 CBF1/CSL knock-out cell lines with recombinant KSHV.219 and selected for viral maintenance by selective medium. Both lines maintained the virus irrespective of their CBF1/CSL status. Viral reactivation could be initiated in both B cell lines but viral genome replication was attenuated in CBF1/CSL deficient lines, which also failed to produce detectable levels of infectious virus. Induction of immediate early, early and late viral genes was impaired in CBF1/CSL deficient cells at multiple stages of the reactivation process but could be restored to wild-type levels by reintroduction of CBF1/CSL. To identify additional viral RTA target genes, which are directly controlled by CBF1/CSL, we analyzed promoters of a selected subset of viral genes. We show that the induction of the late viral genes ORF29a and ORF65 by RTA is strongly enhanced by CBF1/CSL. Orthologs of ORF29a in other herpesviruses are part of the terminase complex required for viral packaging. ORF65 encodes the small capsid protein essential for capsid shell assembly. Our study demonstrates for the first time that in human B cells viral replication can be initiated in the absence of CBF1/CSL but the reactivation process is severely attenuated at all stages and does not lead to virion production. Thus, CBF1/CSL acts as a global hub which is used by the virus to coordinate the lytic cascade.

  14. Insights into siloxane removal from biogas in biotrickling filters via process mapping-based analysis.

    Science.gov (United States)

    Soreanu, Gabriela

    2016-03-01

    Data process mapping using response surface methodology (RSM)-based computational techniques is performed in this study for the diagnosis of a laboratory-scale biotrickling filter applied for siloxane (i.e. octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5)) removal from biogas. A mathematical model describing the process performance (i.e. Si removal efficiency, %) was obtained as a function of key operating parameters (e.g biogas flowrate, D4 and D5 concentration). The contour plots and the response surfaces generated for the obtained objective function indicate a minimization trend in siloxane removal performance, however a maximum performance of approximately 60% Si removal efficiency was recorded. Analysis of the process mapping results provides indicators of improvement to biological system performance.

  15. Differential Regulatory Mechanisms of CBF Regulon Between Nipponbare (Japonica) and 93-11 (Indica) During Cold Acclimation

    Institute of Scientific and Technical Information of China (English)

    PAN Xiao-wu; LI Yong-chao; LI Xiao-xiang; LIU Wen-qiang; MING Jun; LU Ting-ting; TAN Jiang

    2013-01-01

    Nine CBF/DREB1 homologous genes in rice were obtained by BLAST search in the NCBI database,which share conserved amino acid sequences with DREB1 protein in Arabidopsis.Three CBF genes organized in tandem,named OsCBF1,OsCBF2 and OsCBF3,showed a transient induction in the process of cold acclimation,much stronger in indica rice 93-11 compared with japonica rice Nipponbare.The candidate downstream genes OsLIP5 and OsLIP9 were induced in 93-11 but not in Nipponbare.The differential expression of CBF regulon might be caused by polymorphisms within promoter sequences between these two rice varieties.These results could be useful for utilization of CBF/DREB1 genes and illustration of differences in chilling tolerance between indica and japonica rice varieties.

  16. Acute marijuana effects on rCBF and cognition: a PET study.

    Science.gov (United States)

    O'Leary, D S; Block, R I; Flaum, M; Schultz, S K; Boles Ponto, L L; Watkins, G L; Hurtig, R R; Andreasen, N C; Hichwa, R D

    2000-11-27

    The effects of smoking marijuana on cognition and brain function were assessed with PET using H2(15)O. Regional cerebral blood flow (rCBF) was measured in five recreational users before and after smoking a marijuana cigarette, as they repeatedly performed an auditory attention task. Blood flow increased following smoking in a number of paralimbic brain regions (e.g. orbital frontal lobes, insula, temporal poles) and in anterior cingulate and cerebellum. Large reductions in rCBF were observed in temporal lobe regions that are sensitive to auditory attention effects. Brain regions showing increased rCBF may mediate the intoxicating and mood-related effects of smoking marijuana, whereas reduction of task-related rCBF in temporal lobe cortices may account for the impaired cognitive functions associated with acute intoxication.

  17. 巨桉EgrCBF1和EgrCBF2基因的克隆和胁迫响应表达分析%Cloning of EgrCBF1 and EgrCBF2 Genes from Eucalyptus grandis and their Expression under Stresses

    Institute of Scientific and Technical Information of China (English)

    王京京; 童再康; 黄程前; 程龙军

    2012-01-01

    Two CBF genes named EgrCBFl and EgrCBF2 ( GenBank No. JQ068827 ; JQ068828 ) were isolated from Eucalyptus grandis seedlings under low temperature. Sequence analysis showed that EgrCBFl and EgrCBFl cDNA had 1 062 bp and 1 203 bp, respectively. The two genes encoded 220 and 196 amino acids, separately and both contained an AP2 domain. The results of homology comparison showed that EgrCBFl and EgrCBF2 protein shared 91% and 80% homology with EguCBFla. Spatial expression analyses showed that EgrCBFl expressed mainly in leaves and roots while EgrCBF2 expressed in all leaves, stems and roots. qRT-PCR result of EgrCBFl and EgrCBFl under 0 ℃ ,2 ℃ ,4 ℃ ,6 ℃ , and 8 ℃ revealed that they were both induced by low temperatures and reached the highest level at 2 ℃ . Time course of the genes expressions at 4 ℃ for 2 h,4 h,8 h,24 h,and 48 h showed that their expressions increased at the first and then decreased. Changes in EgrCBFl and EgrCBFl expression under 100 μmol · L-1 ABA, 200 mmol·L-1 NaCl and drought were also analyzed. The results showed EgrCBFl was up-regulated under drought stress and ABA treatment, while the expression of EgrCBF2 increased under drought and salt stress.%从低温诱导的巨桉幼苗中克隆到2条CBF的全长cDNA序列,命名为EgrCBF1和EgrCBF2,全长分别为1 062 bp和1 203 bp,编码220个氨基酸和196个氨基酸,命名为EgrCBF1和EgrCBF2(GenBank登录号分别为:JQ068827; JQ068828),都包含1个AP2结构域.2个基因编码的蛋白都与冈尼桉中CBF蛋白(DQ241820)具有很高的同源性,与EguCBF1a的同源性分别达到了91%和80%.RT-PCR分析表明,EgrCBF1主要在叶和根中表达,而EgrCBF2在叶、茎和根中都有表达.对不同低温条件(0,2,4,6,8℃)和4℃2,4,8,24,48 h处理下EgrCBF1和EgrCBF2的qRT-PCR分析表明:2个基因都受低温诱导,并在2℃时诱导水平达到最高;4℃下随低温时间的延长,它们的诱导表达特性都呈先升后降的趋势.在100 μmol·L-1 ABA,200 mmol

  18. Prognostic value of rCBF measurements and CT in focal cerebral ischemia

    International Nuclear Information System (INIS)

    CT is the most effective examination technique for studying the evolution of ischemic attacks, but if performed within the first 3 weeks it does not allow prognosis of possible evolution towards necrosis. CBF measurement and vasoreactivity tests under Althesin do allow this prognosis. Thirty patients whose evolution was checked clinically and by repeated CT examinations (89 in all) underwent CBF measurements (intra-arterial xenon 133) and vasoreactivity had completely disappeared (inverse steal), the infarct evolved towards necrosis. (orig.)

  19. The effect of education on rCBF changes in Alzheimer's disease: a longitudinal SPECT study

    International Nuclear Information System (INIS)

    To determine the relationship of differing levels of education on regional cerebral blood flow (rCBF) in patients with Alzheimer's disease (AD). Fifty-three patients with AD followed-up for an average of 36 months were divided into the high-educated group (HE, ≥12 years of schooling) and low-educated group (LE, 123I]-iodoamphetamine and the SPECT data were analyzed by 3D-stereotactic surface projections. At initial evaluation, the HE group had greater rCBF deficits in the parietotemporal regions than did the LE group, even though both groups had comparable MMSE and FAST scores. When compared with initial SPECT, follow-up SPECT showed a significant rCBF reduction in widespread regions, including the frontal, parietal, temporal, and limbic lobes of the HE group, while it a significant rCBF reduction in scattered and small regions of the parietotemporal, cingulate, and occipital areas of the LE group, as the HE group had faster cognitive and functional decline than the LE group. The HE group showed lower rCBF at initial SPECT than the LE group, suggesting more advanced AD pathology. As a result, the HE group demonstrated a more extensive and severe reduction of rCBF on follow-up SPECT in association with faster cognitive and functional decline than the LE group. Our SPECT study provides stronger support for the cognitive reserve effects of education in AD. (orig.)

  20. An apple rootstock overexpressing a peach CBF gene alters growth and flowering in the scion but does not impact cold hardiness or dormancy

    Science.gov (United States)

    The C-repeat Binding Factor (CBF) transcription factor is involved in responses to low temperature and water deficit in many plant species. Overexpression of CBF genes leads to enhanced freezing tolerance and growth inhibition in many species. The overexpression of a peach CBF (PpCBF1) gene in a t...

  1. Insights on Arctic Sea Ice Processes from New Seafloor and Coastline Mapping

    Science.gov (United States)

    Nghiem, S. V.; Hall, D. K.; Rigor, I. G.; Clemente-Colon, P.; Li, P.; Neumann, G.

    2014-12-01

    The seafloor can exert a significant control on Arctic sea ice patterns by guiding the distribution of ocean water masses and river discharge in the Arctic Ocean. Satellite observations of sea ice and surface temperature are used together with bathymetry data to understand dynamic and thermodynamic processes of sea ice. In particular, data from satellite radars, including scatterometer and synthetic aperture radar (SAR) instruments, are used to identify and map sea ice with different spatial and temporal resolutions across the Arctic. Data from a satellite spectroradiometer, such as MODIS, are used to accurately measure surface temperature under clear sky conditions. For seafloor measurements, advances have been made with new observations surveyed to modern standards in different regions of the Arctic, enabling the production of an improved bathymetry dataset, such as the International Bathymetric Chart of the Arctic Ocean Version 3.0 (IBCAO 3.0) released in 2012. The joint analyses of these datasets reveal that the seafloor can govern warm- and cold-water distribution and thereby dictate sea ice patterns on the sea surface from small local scales to a large regional scale extending over thousands of km. Satellite results show that warm river waters can intrude into the Arctic Ocean and affect sea ice melt hundreds of km away from the river mouths. The Arctic rivers bring significant heat as their waters come from sources across vast watersheds influenced by warm continental climate effects in summertime. In the case of the Mackenzie River, results from the analysis with the new IBCAO 3.0 indicated that the formation and break-up of landfast sea ice is related to the depth and not the slope of the seafloor. In turn, such ice processes can impact the discharge and distribution of warm river waters and influence the melting of sea ice. Animations of satellite observations of sea ice overlaid on both the old and new versions of IBCAO will be presented to illustrate

  2. Altered relationships between rCBF in different brain regions of never-treated schizophrenics

    Energy Technology Data Exchange (ETDEWEB)

    Sabri, O.; Schreckenberger, M.; Cremerius, U.; Dickmann, C.; Schulz, G.; Zimny, M.; Buell, U. [Technische Hochschule Aachen (Germany). Dept. of Nuclear Medicine; Erkwoh, R.; Owega, A.; Sass, H. [Technische Hochschule Aachen (Germany). Dept. of Psychiatry

    1997-09-01

    Aim of this study was to investigate the relations between regional cerebral blood flow (rCBF) of different brain regions in acute schizophrenia and following neuroleptic treatment. Methods: Twenty-two never-treated, acute schizophrenic patients were examined with HMPAO brain SPECT and assessed psychopathologically, and reexamined following neuroleptic treatment (over 96.8 days) and psychopathological remission. rCBF was determined by region/cerebellar count quotients obtained from 98 irregular regions of interest (ROIs), summed up to 11 ROIs on each hemisphere. In acute schizophrenics, interregional rCBF correlations of each ROI to every other ROI were compared to the interregional correlations following neuroleptic treatment and to those of controls. Results: All significant correlations of rCBF ratios of different brain regions were exclusively positive in controls and patients. In controls, all ROIs of one hemisphere except the mesial temporal ROI correlated significantly to its contralateral ROI. Each hemisphere showed significant frontal-temporal correlations, as well as cortical-subcortical and some cortico-limbic. In contrast, in acute schizophrenics nearly every ROI correlated significantly with every other ROI, without a grouping or relation of the rCBF of certain ROIs as in controls. After neuroleptic treatment and clinical improvement, this diffuse pattern of correlations remained. Conclusions: These results indicate differences in the neuronal interplay between regions in schizophrenic and healthy subjects. In nevertreated schizophrenics, diffuse interregional rCBF correlations can be seen as a sign of change and dysfunction of the systems regulating specificity and diversity of the neuronal functions. Neuroleptic therapy and psychopathologic remission showed no normalizing effect on interregional correlations. (orig.) [Deutsch] Ziel der vorliegenden Studie war es, die Beziehungen zwischen den rCBF-Werten von verschiedenen Hirnregionen bei noch nie

  3. Coseismic and Post-seismic landsliding: insights from seismological modeling and landslide map time series.

    Science.gov (United States)

    Marc, Odin; Hovius, Niels; Meunier, Patrick; Uchida, Taro; Gorum, Tolga

    2016-04-01

    Earthquakes impart a catastrophic forcing on hillslopes, that often lead to widespread landsliding and can contribute significantly to sedimentary and organic matter fluxes. We present a new expression for the total area and volume of populations of earthquake-induced landslides.This model builds on a set of scaling relationships between key parameters, such as landslide density, ground acceleration, fault size, earthquake source depth and seismic moment, derived from geomorphological and seismological observations. To assess the model we have assembled and normalized a catalogue of landslide inventories for 40 earthquakes. We have found that low landscape steepness systematically leads to over-prediction of the total area and volume of landslides.When this effect is accounted for, the model is able to predict within a factor of 2 the landslide areas and associated volumes for about two thirds of the cases in our databases. This is a significant improvement on a previously published empirical expression based only on earthquake moment. This model is suitable for integration into landscape evolution models, and application to the assessment of secondary hazards and risks associated with earthquakes. However, it only models landslides associated to the strong ground shaking and neglects the intrinsic permanent damage that also occurred on hillslopes and persist for longer period. With time series of landslide maps we have constrained the magnitude of the change in landslide susceptibility in the epicentral areas of 4 intermediate to large earthquakes. We propose likely causes for this transient ground strength perturbations and compare our observations to other observations of transient perturbations in epicentral areas, such as suspended sediment transport increases, seismic velocity reductions and hydrological perturbations. We conclude with some preliminary observations on the coseismic mass wasting and post-seismic landslide enhancement caused by the 2015 Mw.7

  4. Seismic Data from the Kane Basin, Northwest Greenland - Insight into a white spot on the map

    Science.gov (United States)

    Ehrhardt, Axel; Schnabel, Michael; Damm, Volkmar

    2013-04-01

    The opening history of the Baffin Bay and the possible extent of oceanic crust within the basin is a key question in order to reconstruct the plate tectonic development of the Arctic region. To contribute to the scientific discussion, a multi-component geophysical and geological survey was carried out in 2010 in the area of the Northern Baffin Bay. Because of the fortunate ice conditions we seized the chance to go to the Kane Basin, half way between the Baffin Bay in the South and the Lincoln Sea in the North, one of a series of basins that are aligned along the Nares Strait. In addition the unclear situation within the Baffin Bay the Nares Strait is one of the most disputed areas in the Arctic. As the opening of the Baffin Bay and the formation of oceanic crust must have been compensated somewhere between Greenland and Ellesmere Island a transform fault was proposed. However, in particular land geological data does not support this thesis and let assume moreover that no lateral displacement occurred between Greenland and Ellesmere Island. In order to shed some more light onto the potential transform fault (the Wegener Fault) two reflection seismic lines were shot within the eastern Kane Basin supported by sonobuoys. Furthermore, magnetic and gravity data is acquired. This paper presents first insight into the eastern side of the Kane Basin. The eastern Kane Basin is characterized by a deeper rim and a more shallow central part of the basin. The term basin is probably misleading as most of it is floored by Proterozoic crust without any sedimentary beds on top of it. Only in the western part of the Kane Basin a sedimentary infill can be recorded which terminates with an erosional truncation on to the seafloor. The significant amount of sediments and debris that is washed into the Kane Basin by rivers and glaciers is transported to the Baffin Bay Fan by the considerably strong N-S current through the Nares Strait. A pull-apart development of the Kane Basin can't be

  5. Association mapping of flowering time QTLs and insight into their contributions to rapeseed growth habits

    Directory of Open Access Journals (Sweden)

    Nian eWang

    2016-03-01

    Full Text Available Plants have developed sophisticated systems to adapt to local conditions during evolution, domestication and natural or artificial selection. The selective pressures of these different growing conditions have caused significant genomic divergence within species. The flowering time trait is the most crucial factor because it helps plants to maintain sustainable development. Controlling flowering at appropriate times can also prevent plants from suffering from adverse growth conditions, such as drought, winter hardness, and disease. Hence, discovering the genome-wide genetic mechanisms that influence flowering time variations and understanding their contributions to adaptation should be a central goal of plant genetics and genomics. A global core collection panel with 448 inbred rapeseed lines was first planted in four independent environments, and their flowering time traits were evaluated. We then performed a genome-wide association mapping of flowering times with a 60 K SNP array for this core collection. With quality control and filtration, 20,342 SNP markers were ultimately used for further analyses. In total, 312 SNPs showed marker-trait associations in all four environments, and they were based on a threshold p value of 4.06x10-4; the 40 QTLs showed significant association with flowering time variations. To explore flowering time QTLs and genes related to growth habits in rapeseed, selection signals related to divergent habits were screened at the genome-wide level and 117 genomic regions were found. Comparing locations of flowering time QTLs and genes with these selection regions revealed that 20 flowering time QTLs and 224 flowering time genes overlapped with 24 and 81 selected regions, respectively. Based on this study, a number of marker-trait associations and candidate genes for flowering time variations in rapeseed were revealed. Moreover, we also showed that both flowering time QTLs and genes play important roles in rapeseed growth

  6. The cbfs triple mutants reveal the essential functions of CBFs in cold acclimation and allow the definition of CBF regulons in Arabidopsis.

    Science.gov (United States)

    Jia, Yuxin; Ding, Yanglin; Shi, Yiting; Zhang, Xiaoyan; Gong, Zhizhong; Yang, Shuhua

    2016-10-01

    In Arabidopsis, the C-repeat binding factors (CBFs) have been extensively studied as key transcription factors in the cold stress response. However, their exact functions in the cold response remains unclear due to the lack of a null cbf triple mutant. In this study, we used CRISPR/Cas9 technology to mutate CBF1 or CBF1/CBF2 in a cbf3 T-DNA insertion mutant to generate cbf1,3 double and cbf1 cbf2 cbf3 (cbfs) triple mutants. The response of the cbfs triple mutants to chilling stress is impaired. Furthermore, no significant difference in freezing tolerance was observed between the wild-type and the cbf1,3 and cbfs mutants without cold acclimation. However, the cbfs mutants were extremely sensitive to freezing stress after cold acclimation, and freezing sensitivity ranking was cbfs > cbf1,3 > cbf3. RNA-Seq analysis showed that 134 genes were CBF regulated, of which 112 were regulated positively and 22 negatively by CBFs. Our study reveals the essential functions of CBFs in chilling stress response and cold acclimation, as well as defines a set of genes as CBF regulon. It also provides materials for the genetic dissection of components in CBF-dependent cold signaling. PMID:27353960

  7. Multi-way metamodelling facilitates insight into the complex input-output maps of nonlinear dynamic models

    Science.gov (United States)

    2012-01-01

    Background Statistical approaches to describing the behaviour, including the complex relationships between input parameters and model outputs, of nonlinear dynamic models (referred to as metamodelling) are gaining more and more acceptance as a means for sensitivity analysis and to reduce computational demand. Understanding such input-output maps is necessary for efficient model construction and validation. Multi-way metamodelling provides the opportunity to retain the block-wise structure of the temporal data typically generated by dynamic models throughout the analysis. Furthermore, a cluster-based approach to regional metamodelling allows description of highly nonlinear input-output relationships, revealing additional patterns of covariation. Results By presenting the N-way Hierarchical Cluster-based Partial Least Squares Regression (N-way HC-PLSR) method, we here combine multi-way analysis with regional cluster-based metamodelling, together making a powerful methodology for extensive exploration of the input-output maps of complex dynamic models. We illustrate the potential of the N-way HC-PLSR by applying it both to predict model outputs as functions of the input parameters, and in the inverse direction (predicting input parameters from the model outputs), to analyse the behaviour of a dynamic model of the mammalian circadian clock. Our results display a more complete cartography of how variation in input parameters is reflected in the temporal behaviour of multiple model outputs than has been previously reported. Conclusions Our results indicated that the N-way HC-PLSR metamodelling provides a gain in insight into which parameters that are related to a specific model output behaviour, as well as variations in the model sensitivity to certain input parameters across the model output space. Moreover, the N-way approach allows a more transparent and detailed exploration of the temporal dimension of complex dynamic models, compared to alternative 2-way methods

  8. 椰子CBF基因的克隆研究%Study on Cloning of CBF Gene from Coconut (Cocos nucifera)

    Institute of Scientific and Technical Information of China (English)

    肖勇; 杨耀东; 曹红星; 雷新涛; 范海阔; 赵松林; 马子龙

    2012-01-01

    In order to elucidate the molecular mechanism of coconuts cold resistance, this study designed primers according to the CBF gene sequence of oil palm, and then amplified the genomic DNA of Cocos nucifera by using PCR method. The PCR products were retrieved, linked, transformed and sequenced; finally, a DNA sequence of Cocos nucifera was obtained. This sequence had the highest identity (99%) with CBF gene of oil palm, and it was confirmed to be CBF gene. Through the clustering analysis of the cloned CBF gene of coconut and CBF genes of graminaceous crops, the high homology was found between the cloned CBF gene and HvCBF1, Os-DREB1E, HvCBF11, TaCBF11.%为了从分子水平上解析椰子抗寒的机理,以油棕的CBF基因序列设计引物,对椰子的基因组DNA进行PCR扩增,并对PCR产物进行回收、连接、转化以及测序,最后获得了1条DNA序列.这条序列与油棕的CBF基因的同源性高达99%,被证实为CBF基因.将克隆的椰子的CBF基因与禾本科作物的CBF基因进行聚类分析,结果显示:所克隆的CBF基因与HvCBF1、OsDREB1E、HvCB F11和TaCBF11具有较高的同源性.

  9. Regional cerebral blood flow (rCBF) in man during perception of radiant warmth and heat pain.

    Science.gov (United States)

    Ryding, E; Eriksson, M B; Rosén, I; Ingvar, D H

    1985-08-01

    The present study concerns the effects of experimental pain (radiant warmth and heat pain) on regional cerebral blood flow (rCBF) in pretrained subjects. The radiant warmth caused a general rCBF increase. However, if anxiety was avoided, heat pain caused the general rCBF level to return towards the level at rest. Thus, pain sensation per se may not cause a larger rCBF (and metabolic) response than that of the localized tactile stimulation, provided that the element of psychic apprehension and anxiety is eliminated or controlled.

  10. Effects of normal aging on regional CBF and CMRO2 in humans

    International Nuclear Information System (INIS)

    The oxygen-15 continuous inhalation technique and positron emission tomography were used in order to investigate age-related changes of cerebral blood flow (CBF) and oxygen consumption (CMRO2). 27 patients aged 19 to 76 years without evidence of dementia, brain disease or vascular risk factors, were studied. Regional CBF and CMRO2 were calculated in seven different brain structures. In gray matter CBF and CMRO2 decreased with aging (respectively 18% and 17%, p2 was found to be diffuse but to affect principally the frontal and temporo-sylvian cortex. Neuronal loss and/or a diminished metabolic activity of residual neurons are the most likely hypotheses to explain these findings

  11. The sensitivity of CT and rCBF-studies for the pathology of strokes

    International Nuclear Information System (INIS)

    A localized pathology of the cerebral circulation or cerebral metabolism and the morphology of the brain tissue can be visualized by the use of new techniques in radiology and nuclear medicine: measurements of rCBF by radioactive diffusible isotopes, of the densitiy of the brain tissue, by CT, and of the cerebral metabolism regionally by positron-emission tomography. Having studied 475 stroke patients par rCBF measurements and 335 by CT we think it useful to compare the value of these two methods in revealing information on the pathology underlying focal disorders of brain functions due to stroke. (orig./VJ)

  12. 梅花 CBF 转录因子的克隆及表达%Cloning and Expression of CBF Transcription Factor from Prunus mume

    Institute of Scientific and Technical Information of China (English)

    张杰; 张启翔; 杨炜茹

    2012-01-01

    根据GenBank中与梅花同属的桃、甜樱桃等已发表CBFs转录因子序列设计简并引物,采用PCR和RTPCR方法,从梅花基因组DNA和cDNA中克隆CBF转录因子片段.结果表明,两种途径获得的CBF基因序列一致,基因全长821 bp,编码238个氨基酸,其氨基酸序列具有典型的CBF蛋白特征,包含保守的AP2/EREB DNA 结合结构域及CBF家族蛋白特征短多肽序列(PKK/RPAGRxKFxETRHP和DSAWR).氨基酸相似性分析结果表明,该基因与欧洲甜樱桃、矮扁桃等CBF转录因子相似性较高.相对荧光定量PCR结果显示,4℃低温胁迫下,其表达量符合CBF转录因子表达特点,随着胁迫时间的增长表达量呈上升趋势,8h时达峰值,说明该基因在低温胁迫下上调表达.%Primers were designed according to the CBF transcription factors of Peach (Prunus persica), Sweet cherry (Prunus avium) et al from GenBank. Fragments of CBF gene were isolated from Prunus mume by PCR and RT-PCR, The CBF gene was 821 bp long, encoding a putative protein of 238 amino acids;The amino acids sequence owns the characteristics of the CBF protein,which contains an AP2/EREB DNA-binding domain and two special short amino acids sequences;Similarity analysis showed that the nu-cleotide were highly similarity to that of P. avium, P. tenella et al. Relative real-time PCR experiment showed the expression of PmCBFl was coincidence with the expression characteristics of the CBF gene after exposed to 4℃. The expression of PmCBFl increased at beginning and achieved the highest after 8 hour,indicating PmCBFl was induced under low temperature stress.

  13. Heterology expression of the sweet pepper CBF3 gene confers elevated tolerance to chilling stress in transgenic tobacco.

    Science.gov (United States)

    Yang, Sha; Tang, Xian-Feng; Ma, Na-Na; Wang, Li-Yan; Meng, Qing-Wei

    2011-10-15

    Various studies have confirmed that the CBF (C-repeat binding factor) family of transcription factors has a key role in regulating many plants' responses to cold stress. Here we isolated CBF3 from sweet pepper (Capsicum frutescens). Green fluorescent protein (GFP) fusion protein of CfCBF3 was targeted to the nucleus of the onion epidermis cell. RNA gel blot analysis indicated that CfCBF3 was expressed in leaves of sweet pepper and the expression was induced by low temperature, drought and salinity stresses but not by ABA. Overexpression of CfCBF3 under the control of the CaMV35S promoter in tobacco induced expression of orthologs of CBF3-targeted genes and increased chilling tolerance without a dwarf phenotype. Indeed it also led to multiple biochemical and physiological changes associated with chilling stress. Higher levels of proline (Pro) and soluble sugars and lower content of reactive oxygen species (ROS) were observed in transgenic plants. Our results demonstrated that the increase in total unsaturated fatty acids, especially in phosphatidylglycerol (PG) was detected by overexpression of CfCBF3. During exposure to chilling stress, the transgenic lines were less susceptible to chilling-induced photoinhibition than wild-type (WT) plants. These results suggest that overexpression of CfCBF3 led to modification of the fatty acid unsaturation and alleviated the injuries under chilling stress.

  14. Cyclosporine A, FK506, and NIM811 ameliorate prolonged CBF reduction and impaired neurovascular coupling after cortical spreading depression

    DEFF Research Database (Denmark)

    Hansen, Henning Piilgaard; Witgen, Brent Marvin; Rasmussen, Peter;

    2011-01-01

    ), and neurovascular and neurometabolic coupling were unaffected by all three drugs under control conditions. NIM811 augmented the rise in CBF observed during CSD. Cyclosporine A and FK506 ameliorated the persistent decrease in CBF after CSD. All three drugs prevented disruption of neurovascular coupling after CSD...

  15. Determination of relative CMRO2 from CBF and BOLD changes: significant increase of oxygen consumption rate during visual stimulation

    DEFF Research Database (Denmark)

    Kim, S.G.; Rostrup, Egill; Larsson, H.B.;

    1999-01-01

    The blood oxygenation level-dependent (BOLD) effect in functional magnetic resonance imaging depends on at least partial uncoupling between cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) changes. By measuring CBF and BOLD simultaneously, the relative change in CMRO2 can b...

  16. Monitoring CBF in clinical routine by dynamic single photon emission tomography (SPECT) of inhaled xenon-133

    DEFF Research Database (Denmark)

    Sugiyama, H; Christensen, J; Skyhøj Olsen, T;

    1986-01-01

    A very simple and low-cost brain dedicated, rapidly rotating Single Photon Emission Tomograph SPECT is described. Its use in following patients with ischemic stroke is illustrated by two middle cerebral artery occlusion cases, one with persistent occlusion and low CBF in MCA territory, and one with...

  17. Effect of memantine on CBF and CMRO2 in patients with early Parkinson's disease

    DEFF Research Database (Denmark)

    Borghammer, P; Vafaee, M; Ostergaard, K;

    2008-01-01

    Objectives –  Parkinson’s disease (PD) may be associated with increased energy metabolism in overactive regions of the basal ganglia. Therefore, we hypothesized that treatment with the N-methyl-d-aspartate receptor (NMDAR) antagonist memantine would decrease regional cerebral blood flow (rCBF) an...

  18. Fission Yeast CSL Transcription Factors: Mapping Their Target Genes and Biological Roles.

    Directory of Open Access Journals (Sweden)

    Martin Převorovský

    Full Text Available Cbf11 and Cbf12, the fission yeast CSL transcription factors, have been implicated in the regulation of cell-cycle progression, but no specific roles have been described and their target genes have been only partially mapped.Using a combination of transcriptome profiling under various conditions and genome-wide analysis of CSL-DNA interactions, we identify genes regulated directly and indirectly by CSL proteins in fission yeast. We show that the expression of stress-response genes and genes that are expressed periodically during the cell cycle is deregulated upon genetic manipulation of cbf11 and/or cbf12. Accordingly, the coordination of mitosis and cytokinesis is perturbed in cells with genetically manipulated CSL protein levels, together with other specific defects in cell-cycle progression. Cbf11 activity is nutrient-dependent and Δcbf11-associated defects are mitigated by inactivation of the protein kinase A (Pka1 and stress-activated MAP kinase (Sty1p38 pathways. Furthermore, Cbf11 directly regulates a set of lipid metabolism genes and Δcbf11 cells feature a stark decrease in the number of storage lipid droplets.Our results provide a framework for a more detailed understanding of the role of CSL proteins in the regulation of cell-cycle progression in fission yeast.

  19. Ectopic overexpression of SsCBF1, a CRT/DRE-binding factor from the nightshade plant Solanum lycopersicoides, confers freezing and salt tolerance in transgenic Arabidopsis.

    Directory of Open Access Journals (Sweden)

    Lili Zhang

    Full Text Available The C-repeat (CRT/dehydration-responsive element (DRE binding factor (CBF/DREB1 transcription factors play a key role in cold response. However, the detailed roles of many plant CBFs are far from fully understood. A CBF gene (SsCBF1 was isolated from the cold-hardy plant Solanum lycopersicoides. A subcellular localization study using GFP fusion protein indicated that SsCBF1 is localized in the nucleus. We delimited the SsCBF1 transcriptional activation domain to the C-terminal segment comprising amino acid residues 193-228 (SsCBF1(193-228. The expression of SsCBF1 could be dramatically induced by cold, drought and high salinity. Transactivation assays in tobacco leaves revealed that SsCBF1 could specifically bind to the CRT cis-elements in vivo to activate the expression of downstream reporter genes. The ectopic overexpression of SsCBF1 conferred increased freezing and high-salinity tolerance and late flowering phenotype to transgenic Arabidopsis. RNA-sequencing data exhibited that a set of cold and salt stress responsive genes were up-regulated in transgenic Arabidopsis. Our results suggest that SsCBF1 behaves as a typical CBF to contribute to plant freezing tolerance. Increased resistance to high-salinity and late flowering phenotype derived from SsCBF1 OE lines lend more credence to the hypothesis that plant CBFs participate in diverse physiological and biochemical processes related to adverse conditions.

  20. The Indeterminate Domain Protein ROC1 Regulates Chilling Tolerance via Activation of DREB1B/CBF1 in Rice

    Science.gov (United States)

    Dou, Mingzhu; Cheng, Shuai; Zhao, Baotian; Xuan, Yuanhu; Shao, Minglong

    2016-01-01

    Abiotic stress, including salinity, drought and cold, severely affect diverse aspects of plant development and production. Rice is an important crop that does not acclimate to cold; therefore, it is relatively sensitive to low temperature stress. Dehydration-responsive element-binding protein 1s (DREB1s)/C-repeat binding factors (CBFs) are well known for their function in cold tolerance, but the transcriptional regulation of CBFs remains elusive, especially in rice. Here, we performed a yeast one-hybrid assay using the promoter of CBF1, a cold-induced gene, to isolate transcriptional regulators of CBF1. Among the seven candidates identified, an indeterminate domain (IDD) protein named ROC1 (a regulator of CBF1) was further analyzed. The ROC1 transcript was induced by exogenously-treated auxin, while it was not altered by cold or ABA stimuli. ROC1-GFP was localized at the nucleus, and ROC1 showed trans-activation activity in yeast. The electrophoretic mobility shift assay (EMSA) and ChIP analyses revealed that ROC1 directly bound to the promoter of CBF1. Furthermore, ROC1 mutants exhibited chilling-sensitive symptoms and inhibited cold-mediated induction of CBF1 and CBF3, indicating that ROC1 is a positive regulator of cold stress responses. Taken together, this study identified the CBF1 regulator, and the results are important for rice plant adaptation to chilling stress. PMID:26927068

  1. Functional Cluster Analysis of CT Perfusion Maps: A New Tool for Diagnosis of Acute Stroke?

    OpenAIRE

    Baumgartner, Christian; Gautsch, Kurt; Böhm, Christian; Felber, Stephan

    2005-01-01

    CT perfusion imaging constitutes an important contribution to the early diagnosis of acute stroke. Cerebral blood flow (CBF), cerebral blood volume (CBV) and time-to-peak (TTP) maps are used to estimate the severity of cerebral damage after acute ischemia. We introduce functional cluster analysis as a new tool to evaluate CT perfusion in order to identify normal brain, ischemic tissue and large vessels. CBF, CBV and TTP maps represent the basis for cluster analysis applying a partitioning (k-...

  2. An evaluation of the regional cerebral blood flow (rCBF) measurement by xenon-enhanced dynamic CT with helical scanning technique and the functional imaging by multiplanar reconstruction (MPR). Fundamental study and clinical application

    International Nuclear Information System (INIS)

    We evaluated the quantitative rCBF by xenon-enhanced dynamic CT with helical scanning technique on all brain regions, and also examined clinical usefulness of coronal and sagittal section images which are similar to SPECT images obtained by the functional multiplanar reconstitution (MPR) imaging of many successive flow maps. We used 14 clinical cases. The conventional xenon-enhanced CT was simple and ideal method to measure rCBF, however, it had disadvantages; it gives a few laminagraphical images or only the axial directional images, compared to SPECT or PET. There is a risk to overlook lesions out of the image or not to obtain the whole images of the lesion. Although the helical scanning technique has a methodological characteristics to use adjacent data for the image reconstitution, it is by no means inferior to the conventional method in the contrast resolution or the image resolution when the co-helical function and an appropriate reconstituted function were used. It has an advantage to scan all brain regions by only one cycle of scanning. Furthermore on making good use of the property that the helical scanning technique can give the successive data, we can observe rCBF by coronal and sagittal images when many flow maps were made up by reconstituted images of the narrow steps. This shows the clinical usefulness of this technique. One of the future problem to be solved is to decrease the exposure dose. (K.H.)

  3. Oil palm EgCBF3 conferred stress tolerance in transgenic tomato plants through modulation of the ethylene signaling pathway.

    Science.gov (United States)

    Ebrahimi, Mortaza; Abdullah, Siti Nor Akmar; Abdul Aziz, Maheran; Namasivayam, Parameswari

    2016-09-01

    CBF/DREB1 is a group of transcription factors that are mainly involved in abiotic stress tolerance in plants. They belong to the AP2/ERF superfamily of plant-specific transcription factors. A gene encoding a new member of this group was isolated from ripening oil palm fruit and designated as EgCBF3. The oil palm fruit demonstrates the characteristics of a climacteric fruit like tomato, in which ethylene has a major impact on the ripening process. A transgenic approach was used for functional characterization of the EgCBF3, using tomato as the model plant. The effects of ectopic expression of EgCBF3 were analyzed based on expression profiling of the ethylene biosynthesis-related genes, anti-freeze proteins (AFPs), abiotic stress tolerance and plant growth and development. The EgCBF3 tomatoes demonstrated altered phenotypes compared to the wild type tomatoes. Delayed leaf senescence and flowering, increased chlorophyll content and abnormal flowering were the consequences of overexpression of EgCBF3 in the transgenic tomatoes. The EgCBF3 tomatoes demonstrated enhanced abiotic stress tolerance under in vitro conditions. Further, transcript levels of ethylene biosynthesis-related genes, including three SlACSs and two SlACOs, were altered in the transgenic plants' leaves and roots compared to that in the wild type tomato plant. Among the eight AFPs studied in the wounded leaves of the EgCBF3 tomato plants, transcript levels of SlOSM-L, SlNP24, SlPR5L and SlTSRF1 decreased, while expression of the other four, SlCHI3, SlPR1, SlPR-P2 and SlLAP2, were up-regulated. These findings indicate the possible functions of EgCBF3 in plant growth and development as a regulator of ethylene biosynthesis-related and AFP genes, and as a stimulator of abiotic stress tolerance.

  4. Oil palm EgCBF3 conferred stress tolerance in transgenic tomato plants through modulation of the ethylene signaling pathway.

    Science.gov (United States)

    Ebrahimi, Mortaza; Abdullah, Siti Nor Akmar; Abdul Aziz, Maheran; Namasivayam, Parameswari

    2016-09-01

    CBF/DREB1 is a group of transcription factors that are mainly involved in abiotic stress tolerance in plants. They belong to the AP2/ERF superfamily of plant-specific transcription factors. A gene encoding a new member of this group was isolated from ripening oil palm fruit and designated as EgCBF3. The oil palm fruit demonstrates the characteristics of a climacteric fruit like tomato, in which ethylene has a major impact on the ripening process. A transgenic approach was used for functional characterization of the EgCBF3, using tomato as the model plant. The effects of ectopic expression of EgCBF3 were analyzed based on expression profiling of the ethylene biosynthesis-related genes, anti-freeze proteins (AFPs), abiotic stress tolerance and plant growth and development. The EgCBF3 tomatoes demonstrated altered phenotypes compared to the wild type tomatoes. Delayed leaf senescence and flowering, increased chlorophyll content and abnormal flowering were the consequences of overexpression of EgCBF3 in the transgenic tomatoes. The EgCBF3 tomatoes demonstrated enhanced abiotic stress tolerance under in vitro conditions. Further, transcript levels of ethylene biosynthesis-related genes, including three SlACSs and two SlACOs, were altered in the transgenic plants' leaves and roots compared to that in the wild type tomato plant. Among the eight AFPs studied in the wounded leaves of the EgCBF3 tomato plants, transcript levels of SlOSM-L, SlNP24, SlPR5L and SlTSRF1 decreased, while expression of the other four, SlCHI3, SlPR1, SlPR-P2 and SlLAP2, were up-regulated. These findings indicate the possible functions of EgCBF3 in plant growth and development as a regulator of ethylene biosynthesis-related and AFP genes, and as a stimulator of abiotic stress tolerance. PMID:27513726

  5. Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine

    DEFF Research Database (Denmark)

    Olesen, J; Larsen, B; Lauritzen, M

    1981-01-01

    migraine was similarly followed during his only classic attack. The attacks were initiated by focal hyperemia in 3 patients. During prodromes all patients displayed occipitoparietal rCBF reduction (oligemia), but in only 1 case did the reduction approach critical values. Oligemia gradually spread...... anteriorly in the course of 15 to 45 minutes. In 4 patients a global oligemia was observed. In 4 patients severe headache was present concomitantly with oligemia and with no sign of hyperemia or nonhomogeneous brain perfusion. The normal rCBF increase during cortical activity (hand movement, speech, and...... similar activities) was impaired in 6 patients. The results indicate that the vasospastic model of the migraine attack is too simplistic....

  6. DREB1/CBF transcription factors: their structure, function and role in abiotic stress tolerance in plants

    Indian Academy of Sciences (India)

    M. Akhtar; A. Jaiswal; G. Taj; J. P. Jaiswal; M. I. Qureshi; N. K. Singh

    2012-12-01

    Drought, high salinity and low temperature are major abiotic stresses that influence survival, productivity and geographical distribution of many important crops across the globe. Plants respond to these environmental challenges via physiological, cellular and molecular processes, which results in adjusted metabolic and structural alterations. The dehydration-responsive-element-binding (DREB) protein / C-repeat binding factors (CBFs) belong to APETALA2 (AP2) family transcription factors that bind to DRE/CRT cis-element and regulate the expression of stress-responsive genes. DREB1/CBF genes, therefore, play an important role in increasing stress tolerance in plants and their deployment using transgenic technology seems to be a potential alternative in management of abiotic stresses in crop plants. This review is mainly focussed on the structural characteristics as well as transcriptional regulation of gene expression in response to various abiotic stresses, with particular emphasis on the role of DREB1/CBF regulon in stress-responsive gene expression. The recent progress related to genetic engineering of DREB1/CBF transcription factors in various crops and model plants is also summarized.

  7. Usefulness of rCBF SPECT in patients with encephalitis. Comparison study with MRI

    Energy Technology Data Exchange (ETDEWEB)

    Nagamachi, Shigeki; Jinnouchi, Seishi; Flores, L.G. II; Kodama, Takao; Itokazu, Naoya; Nakahara, Hiroshi; Ohnishi, Takashi; Futami, Shigemi; Watanabe, Katsushi [Miyazaki Medical Coll., Kiyotake (Japan)

    1997-01-01

    Twenty-nine rCBF SPECT study was done in 17 patients with encephalitis. Five of 6 patients (83.3%) showed regional high uptake in acute phase within a week after onset and 16 of 23 studies (69.6%) showed regional low uptake in subacute and chronic phase. Six of 19 lesions (31.6%) with regional high uptake changed to low uptake and 11 lesions (57.9%) improved to normal uptake on follow up studies. Seventeen of 51 lesions with low uptake (33.3%) improved to normal uptake. On the comparative study with MRI, 8 of 18 (44.4%) high uptake area showed cortical thickness or high intensity on T{sub 2} weighted images. Thirty-six of 74 low uptake area (48.6%) showed cortical thickness, brain atrophy or high intensity on T{sub 2} weighted images. Forty-eight of 212 regions (22.6%) with normal MRI findings showed abnormal accumulation of cerebral tracer on rCBF SPECT studies. rCBF SPECT was useful tool for diagnosis and follow up management in patients with encephalitis. (author)

  8. Geologic Mapping of Bakhuysen Crater, Mars: Analogies to the Ries Impact Ejecta with Insights into Martian Impact Melt

    Science.gov (United States)

    Caudill, C. M.; Osinski, G. R.; Tornabene, L. L.

    2016-08-01

    In this study, we report the mapping and geologic interpretation of 150-km diameter Bakhuysen Crater, Mars, which supports previous work suggesting similar mechanisms of multi-unit ejecta emplacement on other comparable rocky bodies.

  9. Cyclosporine A, FK506, and NIM811 ameliorate prolonged CBF reduction and impaired neurovascular coupling after cortical spreading depression

    DEFF Research Database (Denmark)

    Hansen, Henning Piilgaard; Witgen, Brent Marvin; Rasmussen, Peter;

    2011-01-01

    Cortical spreading depression (CSD) is associated with mitochondrial depolarization, increasing intracellular Ca(2+), and the release of free fatty acids, which favor opening of the mitochondrial permeability transition pore (mPTP) and activation of calcineurin (CaN). Here, we test the hypothesis...... and the specific CaN blocker FK506. Cortical spreading depression was induced in rat frontal cortex. Electrocortical activity was recorded by glass microelectrodes, CBF by laser Doppler flowmetry, and tissue oxygen tension with polarographic microelectrodes. Electrocortical activity, basal CBF, CMRO(2......), and neurovascular and neurometabolic coupling were unaffected by all three drugs under control conditions. NIM811 augmented the rise in CBF observed during CSD. Cyclosporine A and FK506 ameliorated the persistent decrease in CBF after CSD. All three drugs prevented disruption of neurovascular coupling after CSD...

  10. Natural variation in CBF gene sequence, gene expression and freezing tolerance in the Versailles core collection of Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Brunel Dominique

    2008-10-01

    Full Text Available Abstract Background Plants from temperate regions are able to withstand freezing temperatures due to a process known as cold acclimation, which is a prior exposure to low, but non-freezing temperatures. During acclimation, a large number of genes are induced, bringing about biochemical changes in the plant, thought to be responsible for the subsequent increase in freezing tolerance. Key regulatory proteins in this process are the CBF1, 2 and 3 transcription factors which control the expression of a set of target genes referred to as the "CBF regulon". Results To assess the role of the CBF genes in cold acclimation and freezing tolerance of Arabidopsis thaliana, the CBF genes and their promoters were sequenced in the Versailles core collection, a set of 48 accessions that maximizes the naturally-occurring genetic diversity, as well as in the commonly used accessions Col-0 and WS. Extensive polymorphism was found in all three genes. Freezing tolerance was measured in all accessions to assess the variability in acclimated freezing tolerance. The effect of sequence polymorphism was investigated by evaluating the kinetics of CBF gene expression, as well as that of a subset of the target COR genes, in a set of eight accessions with contrasting freezing tolerance. Our data indicate that CBF genes as well as the selected COR genes are cold induced in all accessions, irrespective of their freezing tolerance. Although we observed different levels of expression in different accessions, CBF or COR gene expression was not closely correlated with freezing tolerance. Conclusion Our results indicate that the Versailles core collection contains significant natural variation with respect to freezing tolerance, polymorphism in the CBF genes and CBF and COR gene expression. Although there tends to be more CBF and COR gene expression in tolerant accessions, there are exceptions, reinforcing the idea that a complex network of genes is involved in freezing tolerance

  11. Can the detection of misery perfusion in chronic cerebrovascular disease be based on reductions in baseline CBF and vasoreactivity?

    Energy Technology Data Exchange (ETDEWEB)

    Okazawa, Hidehiko; Kobayashi, Masato; Pagani, Marco; Yonekura, Yoshiharu [University of Fukui, Biomedical Imaging Research Center, Matcuoka-cho, Fukui (Japan); Tsuchida, Tatsuro [Faculty of Medical Sciences, University of Fukui, Department of Radiology, Fukui (Japan); Arai, Yoshikazu; Isozaki, Makoto [University of Fukui, Department of Neurosurgery, Faculty of Medical Sciences, Fukui (Japan)

    2007-01-15

    The aim of this study was to clarify whether decreases in baseline regional cerebral blood flow (rCBF) and in residual cerebral vasoreactivity (CVR), assessed by the acetazolamide (ACZ) challenge, can detect misery perfusion in patients with chronic cerebrovascular disease (CVD). Oxygen extraction fraction (OEF) and other haemodynamic parameters were measured in 115 patients (64{+-}9 years old) with unilateral cerebrovascular steno-occlusive disease (>70% stenosis) using {sup 15}O-gas and water PET. A significant elevation of OEF, by greater than the mean+2SD compared with healthy controls, was defined as misery perfusion. CBF, CVR determined by percent change in CBF after ACZ administration, OEF and other haemodynamic parameters in the territories of the bilateral middle cerebral arteries were analysed. Diagnostic accuracy for the detection of misery perfusion using the criteria determined by baseline CBF and CVR was evaluated in all patients and in only those patients with occlusive lesions. Ten of 24 patients with misery perfusion showed a significant reduction in CVR. Using criteria determined by significant decreases in CVR and baseline CBF, misery perfusion was detected with a sensitivity of 42% and a specificity of 95% in all patients. In patients with occlusive lesions (n=50), sensitivity was higher but specificity was slightly lower. The diagnostic accuracy of the threshold determined by baseline CBF alone was similar in all patients and in only those patients with occlusive lesions, and was higher than that achieved using the asymmetry index of OEF. Reductions in CVR and baseline CBF in the ACZ challenge for CVD would detect misery perfusion with high specificity. Reduction in baseline rCBF is more accurate than reduction in CVR alone for the detection of misery perfusion. (orig.)

  12. Regional partition coefficient of water in patients with cerebrovascular disease and its effect on rCBF assessment

    OpenAIRE

    Hirata, Kenji; Hattori, Naoya; Katoh, Chietsugu; Shiga, Tohru; KURODA, Satoshi; Kubo, Naoki; Usui, Reiko; Kuge, Yuji; Tamaki, Nagara

    2011-01-01

    Objective: Cerebral blood flow (CBF) estimation with C15O2 PET usually assumes a single tissue compartment model and a fixed brain-blood partition coefficient of water. However, the partition coefficient may change in pathological conditions. The purpose of this study was to investigate the changes of partition coefficient of water in pathological regions and its effect on regional CBF assessment. Methods: Study protocol included 22 patients with occlusive cerebrovascular disease to compare p...

  13. Usefulness of CBF measurement in the hyperacute phase of ischemic stroke

    International Nuclear Information System (INIS)

    Thrombolytic therapy has emerged as a new treatment option in the hyperacute stage of ischemic stroke. Although a 15% increase in meaningful recovery has been observed at three months, it can also trigger devastating hemorrhagic transformations. Therefore, it is important to select suitable patients to undergo this treatment. The purpose of the present study was to evaluate the feasibility of cerebral blood flow (CBF) measurement by xenon-enhanced CT (Xe-CT) in patients with acute ischemic stroke as well as its potential in identifying the occluded artery and the stroke subtype. In effect, this study examines the potential for Xe-CT to select the appropriate candidates for thrombolytic therapy. In 36 sequential patients (average age: 64.1±13.1) with sudden-onset of ischemic stroke (except for lacunar stroke) who had presented to our hospital within two hours after the onset, we performed Xe-CT and MRI diffusion-weighted imaging (DWI). A selective cerebral angiography was also done if further evaluation was warranted. We examined the sensitivity of Xe-CT in demonstrating the ischemic area compared with that of DWI, its potential to identify the stroke subtype, its ability to determine infarction and hemorrhage based on CBF thresholds, and its contribution to selection of thrombolysis candidates. Xe-CT was completed safely in 31 out of 34 patients (91%). Within three hours after symptom onset, Xe-CT detected the ischemic area in most of the patients (94%), whereas DWI failed to do so in 24%. Of 14 patients who underwent both Xe-CT and angiography, the diagnosis of the stroke subtype determined by Xe-CT was confirmed to be correct by angiography in 11 patients (79%). The CBF threshold of non-hemorrhagic infarction in the gray matter became constant (19 ml/100 g/min) at 3-5 hours after the onset. In hemorrhagic infarction, however, the threshold was initially found to be lower (9 ml/100 g/min) at 3-5 hours and reaching comparable levels with non-hemorrhagic subtypes

  14. Mapping hyper-extended rift systems offshore and onshore: insights from the Bay of Biscay- Western Pyrenees

    Science.gov (United States)

    Tugend, Julie; Manatschal, Gianreto; Kusznir, Nicolas J.; Masini, Emmanuel; Thinon, Isabelle

    2013-04-01

    Research conducted at present-day passive continental margins shows more varied crustal architectures than previously assumed. New seismic data together with drill-holes have revealed the occurrence of extremely thinned continental crust in the distal part of the margin as well as exhumed serpentinised sub-continental mantle oceanwards. In addition the understanding of the formation of hyper-extended rift systems has also greatly benefited from the study of onshore analogs preserved in mountain belts. The Bay of Biscay and Western Pyrenees correspond to a Lower Cretaceous rift system leading to the development of hyper-extended domains and ultimately oceanic crust in the Bay of Biscay. This domain represents one of the best natural laboratories to study the formation processes and evolution of hyper-extended domains. During late Cretaceous compression, these rifted domains were inverted resulting in the present-day Pyrenean mountain belt. In this contribution, we present a new paleogeographic map of the Bay of Biscay-Pyrenean rift system. We integrate results from previous works and new work using different mapping methods to distinguish distinctive crustal domains related to hyper-extended systems both offshore and onshore. We combine seismic interpretations with gravity anomaly inversion and residual depth anomaly analysis to distinguish the different crustal domains across the offshore margin. Onshore, we use an innovative approach based on observations from present-day rifted margin architecture associated with classical field work to map the former hyper-extended domains. Another outcome of this work is the creation of a crustal thickness map using gravity inversion linking offshore and onshore domains from the Bay of Biscay to that of the Western-Pyrenees. This multidisciplinary approach enables us to investigate the spatial and temporal evolution of the Bay of Biscay rift system with the aim of better understanding the formation of hyper-extended domains

  15. Hadoop: HDFS, MapReduce a výpočty v IBM BigInsights

    OpenAIRE

    Fessl, Adam

    2014-01-01

    This undergraduate thesis thematically appertains to the field of Big Data. Particularly, it concerns Hadoop, an open-source tool, serving for distributed processing and saving data. The object of this thesis is to provide the reader with theoretical knowledge and basic prin-ciples concerning the Apache Hadoop with concentration on the file system HDFS and model for distributed MapReduce computing. Theoretical knowledge and principles are illustrated on modified application WordCount in IBM I...

  16. Brain in situ hybridization maps as a source for reverse-engineering transcriptional regulatory networks: Alzheimer's disease insights.

    Science.gov (United States)

    Acquaah-Mensah, George K; Taylor, Ronald C

    2016-07-15

    Microarray data have been a valuable resource for identifying transcriptional regulatory relationships among genes. As an example, brain region-specific transcriptional regulatory events have the potential of providing etiological insights into Alzheimer Disease (AD). However, there is often a paucity of suitable brain-region specific expression data obtained via microarrays or other high throughput means. The Allen Brain Atlas in situ hybridization (ISH) data sets (Jones et al., 2009) represent a potentially valuable alternative source of high-throughput brain region-specific gene expression data for such purposes. In this study, Allen Brain Atlas mouse ISH data in the hippocampal fields were extracted, focusing on 508 genes relevant to neurodegeneration. Transcriptional regulatory networks were learned using three high-performing network inference algorithms. Only 17% of regulatory edges from a network reverse-engineered based on brain region-specific ISH data were also found in a network constructed upon gene expression correlations in mouse whole brain microarrays, thus showing the specificity of gene expression within brain sub-regions. Furthermore, the ISH data-based networks were used to identify instructive transcriptional regulatory relationships. Ncor2, Sp3 and Usf2 form a unique three-party regulatory motif, potentially affecting memory formation pathways. Nfe2l1, Egr1 and Usf2 emerge among regulators of genes involved in AD (e.g. Dhcr24, Aplp2, Tia1, Pdrx1, Vdac1, and Syn2). Further, Nfe2l1, Egr1 and Usf2 are sensitive to dietary factors and could be among links between dietary influences and genes in the AD etiology. Thus, this approach of harnessing brain region-specific ISH data represents a rare opportunity for gleaning unique etiological insights for diseases such as AD. PMID:27050105

  17. Brain in situ hybridization maps as a source for reverse-engineering transcriptional regulatory networks: Alzheimer's disease insights.

    Science.gov (United States)

    Acquaah-Mensah, George K; Taylor, Ronald C

    2016-07-15

    Microarray data have been a valuable resource for identifying transcriptional regulatory relationships among genes. As an example, brain region-specific transcriptional regulatory events have the potential of providing etiological insights into Alzheimer Disease (AD). However, there is often a paucity of suitable brain-region specific expression data obtained via microarrays or other high throughput means. The Allen Brain Atlas in situ hybridization (ISH) data sets (Jones et al., 2009) represent a potentially valuable alternative source of high-throughput brain region-specific gene expression data for such purposes. In this study, Allen Brain Atlas mouse ISH data in the hippocampal fields were extracted, focusing on 508 genes relevant to neurodegeneration. Transcriptional regulatory networks were learned using three high-performing network inference algorithms. Only 17% of regulatory edges from a network reverse-engineered based on brain region-specific ISH data were also found in a network constructed upon gene expression correlations in mouse whole brain microarrays, thus showing the specificity of gene expression within brain sub-regions. Furthermore, the ISH data-based networks were used to identify instructive transcriptional regulatory relationships. Ncor2, Sp3 and Usf2 form a unique three-party regulatory motif, potentially affecting memory formation pathways. Nfe2l1, Egr1 and Usf2 emerge among regulators of genes involved in AD (e.g. Dhcr24, Aplp2, Tia1, Pdrx1, Vdac1, and Syn2). Further, Nfe2l1, Egr1 and Usf2 are sensitive to dietary factors and could be among links between dietary influences and genes in the AD etiology. Thus, this approach of harnessing brain region-specific ISH data represents a rare opportunity for gleaning unique etiological insights for diseases such as AD.

  18. CBF/DREB转录因子与植物矮化的相关性研究进展%Research Progress of CBF/DREB Transcription Factor and Dwarfism

    Institute of Scientific and Technical Information of China (English)

    包永霞; 满达; 肖波; 韩烈保

    2011-01-01

    CBF/DREB转录因子即干旱应答元件结合蛋白,是一类可以调控多个与干旱、高盐及低温耐性有关的功能基因表达的转录因子家族.很多报道称CBF/DREB转录因子的过量表达使转基因植株产生矮化、晚花现象.着重探讨CBF/DREB转录因子与植物矮化现象相关性与其按化机理,并对草坪草育种新方向进行展望.

  19. A study of cerebral hemodynamics in various cerebrovascular disorders by means of rCBF measurement with single photon emission computed tomography

    International Nuclear Information System (INIS)

    Using single photon emission computed tomography (SPECT) with Xe-133 inhalation method, regional cerebral blood flow (rCBF) was measured for the purpose of analyzing the pathophysiology of various cerebrovascular disorders. Included in this series were 38 normal volunteers (N), 72 patients with ischemic cerebrovascular disease (ICD), 16 with subarachnoid hemorrhage (SAH), 9 with arteriovenous malformation (AVM), 6 with Moyamoya disease (MD), and 4 with hypertensive intracerebral hematoma (HIH). In the N group, rCBF was independent of sex and laterality. Increased rCBF was observed in the frontal region, as compared with other regions. A significantly increased rCBF was observed in the thirties decade of life; the difference in rCBF was, however, not statistically significant above the age of 30 years. In the ICD group, rCBF decreased in association with severer disorder. In cases of severe disorder, a significantly decreased rCBF was observed in the whole area, as compared with the control group. SPECT allowed early detection of decreased rCBF due to vaso-spasm in the SAH group. The groups of AVM, MD, and HIH showed decreased rCBF in the surrounding areas of the lesions. (Namekawa, K.)

  20. Paleoclimatic insights from mapping the global distribution of non-glacial cryogenic landforms in sub-humid montane environments.

    Science.gov (United States)

    Slee, Adrian; Shulmeister, James

    2015-04-01

    Much of the 'periglacial' literature is based on landforms and observations from either high mountains or continental environments dominated by strong winter cooling and/or permafrost conditions. Cryogenic conditions occur in many other settings and some of the most widespread are montane landscapes in mid- to low latitudes. In Australia observations of 'periglacial' landforms have traditionally been limited to higher elevation regions of the Australian Alps and central Tasmania. However, the distribution of relict cryogenic landforms is much wider and extends well into sub-tropical latitudes along the eastern highlands of Australia. Here we map the distribution of relict block deposits (block streams and block fields) of known cryogenic origin so as to delineate the limits of 'periglacial' climatic conditions during cold phases in the Late Quaternary. The mapping is based on image analyses supported by extensive and intensive ground truthing. Three distinct regimes are recognised - a high elevation winter wet regime (Mt Kosciuszko style); a temperate maritime westerly regime (Tasmania style) and, unexpectedly, an east coast (sub-tropical) regime (New England style). We utilise bio-climatic modelling to derive modern climate parameters from the distribution of the block deposits so as to map regions affected by cryogenic conditions in late Quaternary cold periods. We assumed that relative changes in mean cooling and precipitation would be shared by other mid-latitude climate locales worldwide and predicted the likely distribution of block deposits in these areas. A literature review confirms the presence of 'periglacial' style block deposits in the predicted regions, including part of the Iberian Peninsula, the Atlas and Drakensburg Mountains of Africa, the Mediterranean island of Sardinia, the higher volcanoes of Mexico and parts of China, all of which have mean annual precipitation similar to the New England area. However, we also note that many of these areas

  1. Insights into the influence of priors in posterior mapping of discrete morphological characters: a case study in Annonaceae.

    Directory of Open Access Journals (Sweden)

    Thomas L P Couvreur

    Full Text Available BACKGROUND: Posterior mapping is an increasingly popular hierarchical Bayesian based method used to infer character histories and reconstruct ancestral states at nodes of molecular phylogenies, notably of morphological characters. As for all Bayesian analyses specification of prior values is an integrative and important part of the analysis. He we provide an example of how alternative prior choices can seriously influence results and mislead interpretations. METHODS/PRINCIPAL FINDINGS: For two contrasting discrete morphological characters, namely a slow and a fast evolving character found in the plant family Annonaceae, we specified a total of eight different prior distributions per character. We investigated how these prior settings affected important summary statistics. Our analyses showed that the different prior distributions had marked effects on the results in terms of average number of character state changes. These differences arise because priors play a crucial role in determining which areas of parameter space the values of the simulation will be drawn from, independent of the data at hand. However, priors seemed to fit the data better if they would result in a more even sampling of parameter space (normal posterior distribution, in which case alternative standard deviation values had little effect on the results. The most probable character history for each character was affected differently by the prior. For the slower evolving character, the same character history always had the highest posterior probability independent of the priors used. In contrast, the faster evolving character showed different most probable character histories depending on the prior. These differences could be related to the level of homoplasy exhibited by each character. CONCLUSIONS: Although our analyses were restricted to two morphological characters within a single family, our results underline the importance of carefully choosing prior values for posterior

  2. Comparative mapping for bighead carp (Aristichthys nobilis) against model and non-model fishes provides insights into the genomic evolution of cyprinids.

    Science.gov (United States)

    Zhu, Chuankun; Tong, Jingou; Yu, Xiaomu; Guo, Wenjie

    2015-08-01

    Comparative mapping provides an efficient method to connect genomes of non-model and model fishes. In this study, we used flanking sequences of the 659 microsatellites on a genetic map of bighead carp (Aristichthys nobilis) to comprehensively study syntenic relationships between bighead carp and nine model and non-model fishes. Of the five model and two food fishes with whole genome data, Cyprinus carpio showed the highest rate of positive BLAST hits (95.3 %) with bighead carp map, followed by Danio rerio (70.9 %), Oreochromis niloticus (21.7 %), Tetraodon nigroviridis (6.4 %), Gasterosteus aculeatus (5.2 %), Oryzias latipes (4.7 %) and Fugu rubripes (3.5 %). Chromosomal syntenic analyses showed that inversion was the basic chromosomal rearrangement during genomic evolution of cyprinids, and the extent of inversions and translocations was found to be positively correlated with evolutionary relationships among fishes studied. Among the five investigated cyprinids, linkage groups (LGs) of bighead carp, Hypophthalmichthys molitrix and Ctenopharyngodon idella exhibited a one-to-one relationship. Besides, LG 9 of bighead carp and homologous LGs of silver carp and grass carp all corresponded to the chromosomes 10 and 22 of zebrafish, suggesting that chromosomal fission may have occurred in the ancestor of zebrafish. On the other hand, LGs of bighead carp and common carp showed an approximate one-to-two relationship with extensive translocations, confirming the occurrence of a 4th whole genome duplication in common carp. This study provides insights into the understanding of genome evolution among cyprinids and would aid in transferring positional and functional information of genes from model fish like zebrafish to non-model fish like bighead carp. PMID:25627158

  3. Sex-determining chromosomes and sexual dimorphism: insights from genetic mapping of sex expression in a natural hybrid Fragaria × ananassa subsp. cuneifolia.

    Science.gov (United States)

    Govindarajulu, R; Liston, A; Ashman, T-L

    2013-05-01

    We studied the natural hybrid (Fragaria × ananassa subsp. cuneifolia) between two sexually dimorphic octoploid strawberry species (Fragaria virginiana and Fragaria chiloensis) to gain insight into the dynamics of sex chromosomes and the genesis of sexual dimorphism. Male sterility is dominant in both the parental species and thus will be inherited maternally, but the chromosome that houses the sex-determining region differs. Thus, we asked whether (1) the cytotypic composition of hybrid populations represents one or both maternal species, (2) the sex-determining chromosome of the hybrid reflects the location of male sterility within the maternal donor species and (3) crosses from the hybrid species show less sexual dimorphism than the parental species. We found that F. × ananassa subsp. cuneifolia populations consisted of both parental cytotypes but one predominated within each population. Genetic linkage mapping of two crosses showed dominance of male sterility similar to the parental species, however, the map location of male sterility reflected the maternal donor in one cross, but not the other. Moreover, female function mapped to a single region in the first cross, but to two regions in the second cross. Aside from components of female function (fruit set and seed set), other traits that have been found to be significantly sexually dimorphic in the pure species were either not dimorphic or were dimorphic in the opposite direction to the parental species. These results suggest that hybrids experience some disruption of dimorphism in secondary sexual traits, as well as novel location and number of quantitative trait locus (QTL) affecting sex function.

  4. Homology of the cranial vault in birds: new insights based on embryonic fate-mapping and character analysis

    Science.gov (United States)

    Maddin, Hillary C.; Piekarski, Nadine; Sefton, Elizabeth M.; Hanken, James

    2016-08-01

    Bones of the cranial vault appear to be highly conserved among tetrapod vertebrates. Moreover, bones identified with the same name are assumed to be evolutionarily homologous. However, recent developmental studies reveal a key difference in the embryonic origin of cranial vault bones between representatives of two amniote lineages, mammals and birds, thereby challenging this view. In the mouse, the frontal is derived from cranial neural crest (CNC) but the parietal is derived from mesoderm, placing the CNC-mesoderm boundary at the suture between these bones. In the chicken, this boundary is located within the frontal. This difference and related data have led several recent authors to suggest that bones of the avian cranial vault are misidentified and should be renamed. To elucidate this apparent conflict, we fate-mapped CNC and mesoderm in axolotl to reveal the contributions of these two embryonic cell populations to the cranial vault in a urodele amphibian. The CNC-mesoderm boundary in axolotl is located between the frontal and parietal bones, as in the mouse but unlike the chicken. If, however, the avian frontal is regarded instead as a fused frontal and parietal (i.e. frontoparietal) and the parietal as a postparietal, then the cranial vault of birds becomes developmentally and topologically congruent with those of urodeles and mammals. This alternative hypothesis of cranial vault homology is also phylogenetically consistent with data from the tetrapod fossil record, where frontal, parietal and postparietal bones are present in stem lineages of all extant taxa, including birds. It further implies that a postparietal may be present in most non-avian archosaurs, but fused to the parietal or supraoccipital as in many extant mammals.

  5. The usefulness of CBF brain SPECT in forensic medicine. A description of four cases

    International Nuclear Information System (INIS)

    The aim of this study was to show the applications of cerebral blood flow SPECT scanning in forensic medicine using four cases: two suspects and two victims of crime. Cerebral blood flow studies were performed with the use of 99mTc-ECD and a triple head gammacamera. Qualitative and quantitative analysis was performed, utilising an asymmetry index for unilateral perfusion deficits and a comparison to cerebellar perfusion for assessing the regional cerebral perfusion. For assessing the normal values, a control group of 30 patients was studied. In these cases CBF SPECT scanning proved its usefulness in medico-legal argument and played an important role in formulating the final forensic expertTMs opinion. Radionuclide cerebral blood flow studies may play a role in forensic medicine, where this method it is mostly under-utilised at present. (author)

  6. In vivo detection of prion amyloid plaques using [11C]BF-227 PET

    International Nuclear Information System (INIS)

    In vivo detection of pathological prion protein (PrP) in the brain is potentially useful for the diagnosis of transmissible spongiform encephalopathies (TSEs). However, there are no non-invasive ante-mortem means for detection of pathological PrP deposition in the brain. The purpose of this study is to evaluate the amyloid imaging tracer BF-227 with positron emission tomography (PET) for the non-invasive detection of PrP amyloid in the brain. The binding ability of BF-227 to PrP amyloid was investigated using autoradiography and fluorescence microscopy. Five patients with TSEs, including three patients with Gerstmann-Straeussler-Scheinker disease (GSS) and two patients with sporadic Creutzfeldt-Jakob disease (CJD), underwent [11C]BF-227 PET scans. Results were compared with data from 10 normal controls and 17 patients with Alzheimer's disease (AD). The regional to pons standardized uptake value ratio was calculated as an index of BF-227 retention. Binding of BF-227 to PrP plaques was confirmed using brain samples from autopsy-confirmed GSS cases. In clinical PET study, significantly higher retention of BF-227 was detected in the cerebellum, thalamus and lateral temporal cortex of GSS patients compared to that in the corresponding tissues of normal controls. GSS patients also showed higher retention of BF-227 in the cerebellum, thalamus and medial temporal cortex compared to AD patients. In contrast, the two CJD patients showed no obvious retention of BF-227 in the brain. Although [11C]BF-227 is a non-specific imaging marker of cerebral amyloidosis, it is useful for in vivo detection of PrP plaques in the human brain in GSS, based on the regional distribution of the tracer. PET amyloid imaging might provide a means for both early diagnosis and non-invasive disease monitoring of certain forms of TSEs. (orig.)

  7. In vivo detection of prion amyloid plaques using [{sup 11}C]BF-227 PET

    Energy Technology Data Exchange (ETDEWEB)

    Okamura, Nobuyuki; Yanai, Kazuhiko [Tohoku University School of Medicine, Department of Pharmacology, Sendai (Japan); Shiga, Yusei; Itoyama, Yasuhito [Tohoku University School of Medicine, Department of Neurology, Sendai (Japan); Furumoto, Shozo [Tohoku University School of Medicine, Department of Pharmacology, Sendai (Japan); Tohoku University, Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Sendai (Japan); Tashiro, Manabu [Tohoku University, Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Sendai (Japan); Tsuboi, Yoshio [Fukuoka University School of Medicine, Department of Neurology, Fukuoka (Japan); Furukawa, Katsutoshi; Arai, Hiroyuki [Institute of Development, Aging, and Cancer, Tohoku University, Department of Geriatrics and Gerontology, Division of Brain Sciences, Sendai (Japan); Iwata, Ren [Tohoku University, Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Sendai (Japan); Kudo, Yukitsuka [Tohoku University, Innovation of New Biomedical Engineering Center, Sendai (Japan); Doh-ura, Katsumi [Tohoku University School of Medicine, Department of Prion Research, 2-1 Seiryo-machi, Aoba-ku, Sendai (Japan)

    2010-05-15

    In vivo detection of pathological prion protein (PrP) in the brain is potentially useful for the diagnosis of transmissible spongiform encephalopathies (TSEs). However, there are no non-invasive ante-mortem means for detection of pathological PrP deposition in the brain. The purpose of this study is to evaluate the amyloid imaging tracer BF-227 with positron emission tomography (PET) for the non-invasive detection of PrP amyloid in the brain. The binding ability of BF-227 to PrP amyloid was investigated using autoradiography and fluorescence microscopy. Five patients with TSEs, including three patients with Gerstmann-Straeussler-Scheinker disease (GSS) and two patients with sporadic Creutzfeldt-Jakob disease (CJD), underwent [{sup 11}C]BF-227 PET scans. Results were compared with data from 10 normal controls and 17 patients with Alzheimer's disease (AD). The regional to pons standardized uptake value ratio was calculated as an index of BF-227 retention. Binding of BF-227 to PrP plaques was confirmed using brain samples from autopsy-confirmed GSS cases. In clinical PET study, significantly higher retention of BF-227 was detected in the cerebellum, thalamus and lateral temporal cortex of GSS patients compared to that in the corresponding tissues of normal controls. GSS patients also showed higher retention of BF-227 in the cerebellum, thalamus and medial temporal cortex compared to AD patients. In contrast, the two CJD patients showed no obvious retention of BF-227 in the brain. Although [{sup 11}C]BF-227 is a non-specific imaging marker of cerebral amyloidosis, it is useful for in vivo detection of PrP plaques in the human brain in GSS, based on the regional distribution of the tracer. PET amyloid imaging might provide a means for both early diagnosis and non-invasive disease monitoring of certain forms of TSEs. (orig.)

  8. Draft Genome Sequence of Pseudomonas putida CBF10-2, a Soil Isolate with Bioremediation Potential in Agricultural and Industrial Environmental Settings.

    Science.gov (United States)

    Iyer, Rupa; Damania, Ashish

    2016-01-01

    Pseudomonas putida CBF10-2 is a microorganism isolated from farmland soil in Fairchild, TX, found to degrade high-impact xenobiotics, including organophosphate insecticides, petroleum hydrocarbons, and both monocyclic and polycyclic aromatics. The versatility of CBF10-2 makes it useful for multipurpose bioremediation of contaminated sites in agricultural and industrial environments. PMID:27417844

  9. Functional Characterization of Hevea brasiliensis CRT/DRE Binding Factor 1 Gene Revealed Regulation Potential in the CBF Pathway of Tropical Perennial Tree.

    Science.gov (United States)

    Cheng, Han; Cai, Haibin; Fu, Haitian; An, Zewei; Fang, Jialin; Hu, Yanshi; Guo, Dianjing; Huang, Huasun

    2015-01-01

    Rubber trees (Hevea brasiliensis) are susceptible to low temperature and therefore are only planted in the tropical regions. In the past few decades, although rubber trees have been successfully planted in the northern margin of tropical area in China, they suffered from cold injury during the winter. To understand the physiological response under cold stress, we isolated a C-repeat binding factor 1 (CBF1) gene from the rubber tree. This gene (HbCBF1) was found to respond to cold stress but not drought or ABA stress. The corresponding HbCBF1 protein showed CRT/DRE binding activity in gel shift experiment. To further characterize its molecular function, the HbCBF1 gene was overexpressed in Arabidopsis. The HbCBF1 over expression (OE) line showed enhanced cold resistance and relatively slow dehydration, and the expression of Arabidopsis CBF pathway downstream target genes, e.g. AtCOR15a and AtRD29a, were significantly activated under non-acclimation condition. These data suggest HbCBF1 gene is a functional member of the CBF gene family, and may play important regulation function in rubber tree. PMID:26361044

  10. Functional Characterization of Hevea brasiliensis CRT/DRE Binding Factor 1 Gene Revealed Regulation Potential in the CBF Pathway of Tropical Perennial Tree.

    Directory of Open Access Journals (Sweden)

    Han Cheng

    Full Text Available Rubber trees (Hevea brasiliensis are susceptible to low temperature and therefore are only planted in the tropical regions. In the past few decades, although rubber trees have been successfully planted in the northern margin of tropical area in China, they suffered from cold injury during the winter. To understand the physiological response under cold stress, we isolated a C-repeat binding factor 1 (CBF1 gene from the rubber tree. This gene (HbCBF1 was found to respond to cold stress but not drought or ABA stress. The corresponding HbCBF1 protein showed CRT/DRE binding activity in gel shift experiment. To further characterize its molecular function, the HbCBF1 gene was overexpressed in Arabidopsis. The HbCBF1 over expression (OE line showed enhanced cold resistance and relatively slow dehydration, and the expression of Arabidopsis CBF pathway downstream target genes, e.g. AtCOR15a and AtRD29a, were significantly activated under non-acclimation condition. These data suggest HbCBF1 gene is a functional member of the CBF gene family, and may play important regulation function in rubber tree.

  11. Brain SPECT analysis using statistical parametric mapping in patients with transient global amnesia

    Energy Technology Data Exchange (ETDEWEB)

    Kim, E. N.; Sohn, H. S.; Kim, S. H; Chung, S. K.; Yang, D. W. [College of Medicine, The Catholic Univ. of Korea, Seoul (Korea, Republic of)

    2001-07-01

    This study investigated alterations in regional cerebral blood flow (rCBF) in patients with transient global amnesia (TGA) using statistical parametric mapping 99 (SPM99). Noninvasive rCBF measurements using 99mTc-ethyl cysteinate dimer (ECD) SPECT were performed on 8 patients with TGA and 17 age matched controls. The relative rCBF maps in patients with TGA and controls were compared. In patients with TGA, significantly decreased rCBF was found along the left superior temporal extending to left parietal region of the brain and left thalamus. There were areas of increased rCBF in the right temporal, right frontal region and right thalamus. We could demonstrate decreased perfusion in left cerebral hemisphere and increased perfusion in right cerebral hemisphere in patients with TGA using SPM99. The reciprocal change of rCBF between right and left cerebral hemisphere in patients with TGA might suggest that imbalanced neuronal activity between the bilateral hemispheres may be important role in the pathogenesis of the TGA. For quantitative SPECT analysis in TGA patients, we recommend SPM99 rather than the ROI method because of its definitive advantages.

  12. Brain SPECT analysis using statistical parametric mapping in patients with posttraumatic stress disorder

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Euy Neyng; Sohn, Hyung Sun; Kim, Sung Hoon; Chung, Soo Kyo; Yang, Dong Won [College of Medicine, The Catholic Univ. of Korea, Seoul (Korea, Republic of)

    2001-07-01

    This study investigated alterations in regional cerebral blood flow (rCBF) in patients with posttraumatic stress disorder (PTSD) using statistical parametric mapping (SPM99). Noninvasive rCBF measurements using {sup 99m}Tc-ethyl cysteinate dimer (ECD) SPECT were performed on 23 patients with PTSD and 21 age matched normal controls without re-exposure to accident-related stimuli. The relative rCBF maps in patients with PTSD and controls were compared. In patients with PTSD, significant increased rCBF was found along the limbic system in the brain. There were a few foci of decreased rCBF in the superior frontal gyrus, parietal and temporal region. PTSD is associated with increased rCBF in limbic areas compared with age-matched normal controls. These findings implicate regions of the limbic brain, which may mediate the response to aversive stimuli in healthy individuals, play on important role in patients suffering from PTSD and suggest that ongoing hyperfunction of 'overlearned survival response' or flashbacks response in these regions after painful, life threatening, or horrifying events without re-exposure to same traumatic stimulus.

  13. Study on localization diagnosis with SPECT rCBF image in childhood epilepsy: in comparison with EEG and MRI findings

    International Nuclear Information System (INIS)

    Objective: To evaluate the diagnostic value of SPECT rCBF imaging in localization of childhood epileptic foci. Methods: rCBF imaging was performed in 74 epileptic patients not in seizure and 10 epileptic patients right in seizure. EEG was performed in 84, MRI in 67 of the subjects mentioned above. All the results of three modalities were compared with each other. Results: The highest positive rate (82.14%) was found in SPECT rCBF imaging, the positive rate in EEG or MRI was 71.43 or 47.76%. The epileptic foci localized by EEG (60 abnormalities) and by MRI (32 abnormalities) were 70.59% or 58.82% in concordance with those by SPECT, respectively. Conclusions: SPECT rCBF imaging is a sensitive and effective method for epileptic foci localization. It may have some advantages over EEG and MRI in detecting and localizing epileptic foci. However, abnormal SPECT areas may cover some abnormalities which do not belong to epileptic category. A combination of these three methods (SPECT, EEG and MRI) will improve the positive rate and accuracy for localizing

  14. Perfusion and diffusion MRI study detecting CBF disturbance and edema formation in the acute phase of cerebral contusion

    Energy Technology Data Exchange (ETDEWEB)

    Kawamata, Tatsuro; Aoyama, Naoki; Mori, Tatsuro; Maeda, Takeshi; Katayama, Yoichi [Nihon Univ., Tokyo (Japan). School of Medicine

    1998-12-01

    In order to clarify the mechanisms underlying cerebral contusion-induced CBF disturbance and edema formation, echoplanar diffusion and perfusion images were obtained in the patients with cerebral contusion. In the acute phase within 48 hours post-trauma, the apparent diffusion coefficient (ADC) showed various levels with a tendency to increase in the central area of contusion (ADC ratio=1.06{+-}0.21). In contrast, the ADC was significantly reduced in the peripheral area of contusion (ADC ratio=0.87{+-}0.16). The ADC at 2 weeks post-trauma increased both in the central (ADC ratio=1.16{+-}0.26) and the peripheral area of contusion (ADC ratio=1.10{+-}0.26, p<0.05), as compared to those within 48 hours post-trauma. The perfusion images showed a wide spread CBF depression extending beyond the area of contusion observed on the T1 and T2 weighted images. These results indicate that; in the early phase of contusion-induced edema formation, cytotoxic edema is predominant, especially in the peripheral area of contusion, and vasogenic edema appears thereafter. The CBF depression may contribute such cytotoxic edema formation in the surrounding area of cerebral contusion. It is concluded that echo-planar diffusion and perfusion images are excellent technique to investigate the evolution of CBF disturbance and edema formation following traumatic brain injury. (author)

  15. Determination of relative CMRO2 from CBF and BOLD changes: significant increase of oxygen consumption rate during visual stimulation

    DEFF Research Database (Denmark)

    Kim, S.G.; Rostrup, Egill; Larsson, H.B.;

    1999-01-01

    The blood oxygenation level-dependent (BOLD) effect in functional magnetic resonance imaging depends on at least partial uncoupling between cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) changes. By measuring CBF and BOLD simultaneously, the relative change in CMRO2 can be...... estimated during neural activity using a reference condition obtained with known CMRO2 change. In this work, nine subjects were studied at a magnetic field of 1.5 T; each subject underwent inhalation of a 5% carbon dioxide gas mixture as a reference and two visual stimulation studies. Relative CBF and BOLD......(-1), which corresponds to BOLD signal change of 2.4 +/- 0.7% with a gradient echo time of 50 msec. During black/white visual stimulation reversing at 8 Hz, regional CBF increase in the visual cortex was 43.6 +/- 9.4% (n = 18), and deltaR2* was -0.114 +/- 0.086 sec(-1), corresponding to a BOLD signal...

  16. PpCBF3 from Cold-Tolerant Kentucky Bluegrass Involved in Freezing Tolerance Associated with Up-Regulation of Cold-Related Genes in Transgenic Arabidopsis thaliana.

    Directory of Open Access Journals (Sweden)

    Lili Zhuang

    Full Text Available Dehydration-Responsive Element Binding proteins (DREB/C-repeat (CRT Binding Factors (CBF have been identified as transcriptional activators during plant responses to cold stress. The objective of this study was to determine the physiological roles of a CBF gene isolated from a cold-tolerant perennial grass species, Kentucky bluegrass (Poa pratensis L., which designated as PpCBF3, in regulating plant tolerance to freezing stress. Transient transformation of Arabidopsis thaliana mesophyll protoplast with PpCBF3-eGFP fused protein showed that PpCBF3 was localized to the nucleus. RT-PCR analysis showed that PpCBF3 was specifically induced by cold stress (4°C but not by drought stress [induced by 20% polyethylene glycol 6000 solution (PEG-6000] or salt stress (150 mM NaCl. Transgenic Arabidopsis overexpressing PpCBF3 showed significant improvement in freezing (-20°C tolerance demonstrated by a lower percentage of chlorotic leaves, lower cellular electrolyte leakage (EL and H2O2 and O2.- content, and higher chlorophyll content and photochemical efficiency compared to the wild type. Relative mRNA expression level analysis by qRT-PCR indicated that the improved freezing tolerance of transgenic Arabidopsis plants overexpressing PpCBF3 was conferred by sustained activation of downstream cold responsive (COR genes. Other interesting phenotypic changes in the PpCBF3-transgenic Arabidopsis plants included late flowering and slow growth or 'dwarfism', both of which are desirable phenotypic traits for perennial turfgrasses. Therefore, PpCBF3 has potential to be used in genetic engineering for improvement of turfgrass freezing tolerance and other desirable traits.

  17. Dreaming and insight

    OpenAIRE

    Edwards, Christopher L; Perrine Marie RUBY; Malinowski, Josie E.; Bennett, Paul D.; Blagrove, Mark T.

    2013-01-01

    This paper addresses claims that dreams can be a source of personal insight. Whereas there has been anecdotal backing for such claims, there is now tangential support from findings of the facilitative effect of sleep on cognitive insight, and of REM sleep in particular on emotional memory consolidation. Furthermore, the presence in dreams of metaphorical representations of waking life indicates the possibility of novel insight as an emergent feature of such metaphorical mappings. In order to ...

  18. Hypersensitivity to thromboxane receptor mediated cerebral vasomotion and CBF oscillations during acute NO-deficiency in rats.

    Directory of Open Access Journals (Sweden)

    Béla Horváth

    Full Text Available BACKGROUND: Low frequency (4-12 cpm spontaneous fluctuations of the cerebrovascular tone (vasomotion and oscillations of the cerebral blood flow (CBF have been reported in diseases associated with endothelial dysfunction. Since endothelium-derived nitric oxide (NO suppresses constitutively the release and vascular effects of thromboxane A(2 (TXA(2, NO-deficiency is often associated with activation of thromboxane receptors (TP. In the present study we hypothesized that in the absence of NO, overactivation of the TP-receptor mediated cerebrovascular signaling pathway contributes to the development of vasomotion and CBF oscillations. METHODOLOGY/PRINCIPAL FINDINGS: Effects of pharmacological modulation of TP-receptor activation and its downstream signaling pathway have been investigated on CBF oscillations (measured by laser-Doppler flowmetry in anesthetized rats and vasomotion (measured by isometric tension recording in isolated rat middle cerebral arteries, MCAs both under physiological conditions and after acute inhibition of NO synthesis. Administration of the TP-receptor agonist U-46619 (1 µg/kg i.v. to control animals failed to induce any changes of the systemic or cerebral circulatory parameters. Inhibition of the NO synthesis by nitro-L-arginine methyl ester (L-NAME, 100 mg/kg i.v. resulted in increased mean arterial blood pressure and a decreased CBF accompanied by appearance of CBF-oscillations with a dominant frequency of 148±2 mHz. U-46619 significantly augmented the CBF-oscillations induced by L-NAME while inhibition of endogenous TXA(2 synthesis by ozagrel (10 mg/kg i.v. attenuated it. In isolated MCAs U-46619 in a concentration of 100 nM, which induced weak and stable contraction under physiological conditions, evoked sustained vasomotion in the absence of NO, which effect could be completely reversed by inhibition of Rho-kinase by 10 µM Y-27632. CONCLUSION/SIGNIFICANCE: These results suggest that hypersensitivity of the TP

  19. Volumes of chronic traumatic frontal brain lesions measured by MR imaging and CBF tomography

    Energy Technology Data Exchange (ETDEWEB)

    Maeder, P.; Wirsen, A.; Bajc, M.; Schalen, W.; Sjoeholm, H.; Skeidsvoll, H.; Cronqvist, S.; Ingvar, D.H. (University Hospital, Lund (Sweden). Dept. of Neuroradiology University Hospital, Lund (Sweden). Dept. of Clinical Neurophysiology University Hospital, Lund (Sweden). Dept. of Neurosurgery)

    1991-07-01

    The volumes (ml) of chronic traumatic frontal brain lesions were compared measured 'morphologically' with MR imaging (T1 and T2 weighted images) and 'functionally' with a tomographic rCBF technique (SPECT with {sup 133}Xe i.v.). The T1 volumes varied between 11 and 220 ml. The correlation between T1 and T2 volumes was 0.95, the T2 volumes being 33% larger than T1 volumes (p<0.001). The functional SPECT volumes were considerably larger (range 16-324 ml) than the MR volumes. The mean volume difference was 81% between T1 and SPECT images (p<0.001), and 35% between T2 and SPECT images (p<0.001). Correlations between the MR and SPECT volumes were also higher for T2 than T1 volumes. The volume difference is most likely explained by a functional decrease in regions around the lesion in which no morphologic change visible on MR images had taken place. MR and SPECT volume measurements were positively related to persistent lack of energy and personality changes, but only moderately related to duration of impaired consciousness and neuropsychologie outcome. (orig.).

  20. A study on evaluation of frontal lobe epilepsy using statistical parametric mapping of brain perfusion SPECT

    International Nuclear Information System (INIS)

    This study investigates alteration of regional cerebral blood flow (rCBF) and identification of epileptic foci in interictal frontal lobe epilepsy (FLE) using statistical parametric mapping (SPM). Noninvasive rCBF measurements using 99mTc-ECD SPECT were performed on 23 patients with frontal lobe epilepsy and 49 age-matched normal subjects. The FLE patients were divided into three groups, 3 patients with dorsolateral and frontocentral seizures, 2 patients with supplementary motor seizures, and 18 patients with frontobasal-cingulate seizures by Mihara's classification determined by clinical and EEG findings. The SPM analysis revealed rCBF abnormality in frontal lobes in 12 patients when compared rCBF data for each patient with those for normal subjects in accordance with Mihara's classification in 8. On the contrary, rCBF abnormality in frontal lobes was detected in 4 patients by visual inspection in accordance with the classification in only one. The rCBF significantly decreased in orbito-frontal regions, frontopolar regions, and anterior cingulate gyrus in the group with frontobasal-cingulate seizures as compared with age-matched normal subjects with confounding covariates of plasma concentrations of antiepileptic drugs. These results suggest that SPM analysis of brain perfusion SPECT gives us useful information about frontal lobe epilepsy even in the interictal phase. (author)

  1. Study on the preparation of the compound bioflocculant CBF-1 and its flocculation properties%复合生物絮凝剂CBF-1的制备及其絮凝特性

    Institute of Scientific and Technical Information of China (English)

    雷志斌; 胡勇有; 于琪

    2012-01-01

    Compound bioflocculant ( CBF-1 ) was prepared by mechanical mixing of microbial fiocculant (MBF8) and biopolymeric floceulant (CG-A). The functional group, electrical and the framework characteristics of CBF-1 were determined by Fourier transform infrared (FTIR) , Zeta electric potential method and transmission electron microscope ( TEM), respectively. Moreover, the flocculating properties of CBF-1 on treating kaolin suspension were also examined. The results showed that the optimum weight ratio of CG- A : MBF8 was 4 : 6. CBF- 1 was pale yellow solution with 0. 013% of undissolved substance. The pH value, relative viscosity ( effective constituent O. 5% , 30 ℃ ) and isoionic point ( effective constituent O. 1% ) of such solution were 6. 1, 1.72 and pH = 1.5, respectively. The main specific functional groups were hydroxyl group, carboxyl group, amino group, amide group and phosphate group. With the PAC dosage of 3 mg" L - 1 and the CBF-1 dosage range from 1.0 to 8.0 mg" L - 1, the optimum pH value was 6.0 ~ 10.0 and the optimum ionic strength was 0.5 ~ 5.0 mmol. L - I for the Jar tests. For the kaolin suspension with turbidity of 100 NTU, the removal rate of turbidity could achieve 92% and the residual aluminum was less than 75 μg·L-l under a reaction pH of 8.0 and ionic strength of 3.0 mmol·L-l For the kaolin suspension with turbidity of 6 to 300 NTU, the removal efficiency of turbidity ranged from 61% to 98%.%采用机械混合的方法,将微生物絮凝剂MBF8与植物胶粉羧甲基改性絮凝剂CG-A复合制备了新型高效复合生物絮凝剂CBF-1.采用FT-IR、zeta(ξ)电位、透射电镜分析,确定了CBF-1的特征官能团、电荷性及分子胶束形态等物化性质;采用烧杯絮凝实验,探究了CBF-1的絮凝特性.结果表明,制备CBF-1的最佳CG-A∶MBF8质量复合比为4∶6;CBF-1为含少量沉淀物的淡黄色液体(不溶物0.013%),有效成分为0.5%,pH6.1,相对粘度1.72;有效成分0.1%时等电点约pH1.5;主

  2. Increased Drought Tolerance through the Suppression of ESKMO1 Gene and Overexpression of CBF-Related Genes in Arabidopsis

    OpenAIRE

    Fuhui Xu; Zhixue Liu; Hongyan Xie; Jian Zhu; Juren Zhang; Josef Kraus; Tasja Blaschnig; Reinhard Nehls; Hong Wang

    2014-01-01

    Improved drought tolerance is always a highly desired trait for agricultural plants. Significantly increased drought tolerance in Arabidopsis thaliana (Columbia-0) has been achieved in our work through the suppression of ESKMO1 (ESK1) gene expression with small-interfering RNA (siRNA) and overexpression of CBF genes with constitutive gene expression. ESK1 has been identified as a gene linked to normal development of the plant vascular system, which is assumed directly related to plant drought...

  3. Identification of CBF14 and NAC2 Genes in Aegilops tauschii Associated with Resistance to Freezing Stress.

    Science.gov (United States)

    Masoomi-Aladizgeh, Farhad; Aalami, Ali; Esfahani, Masoud; Aghaei, Mohamad Jaafar; Mozaffari, Khadijeh

    2015-06-01

    Low temperature as one of the most important environmental factors limits the productivity of plants across the world. Aegilops, as a wild species of Poaceae, contains low temperature-responsive genes. In this study, we analyzed morphological (wilting, chlorosis, and recovery) and physiological (ion leakage) characteristics to identification of a cold-tolerant genotype. In this experiment, we introduced two transcription factors (TFs) in Aegilops species for the first time. Bioinformatics analysis demonstrated that our nucleotide sequences have high similarity with CBF14 (C-repeat-binding factor) and NAC2 (NAM, ATAF, and CUC) in Triticum aestivum. Based on the physiological and morphological data, one genotype (Aladizgeh) was identified as the most resistant genotype which was selected for further gene expression analysis. The real-time PCR results indicated that the CBF14 gene was not expressed 3 h following cold treatment, but the highest expression was observed after 6, 12, and 24 h of cold treatment; however, a sudden decrease was observed in its expression after 30 h. The NAC2 gene also was not expressed 3 h after cold stress, but the highest expression was at 24 h and similar to the CBF14 gene; its expression suddenly decreased after 30 h. Our results indicated that this genotype can tolerate -4 °C for 3 h, but the CBF14 and NAC2 genes were activated when treated for longer durations. Expression of TFs studied in this experiment had decreased after 30 h, in which cell death seems to be the important reason.

  4. Cloning and characterization of Arabidopsis thaliana AtNAP57--a homologue of yeast pseudouridine synthase Cbf5p.

    Science.gov (United States)

    Maceluch, J; Kmieciak, M; Szweykowska-Kulińska, Z; Jarmołowski, A

    2001-01-01

    Rat Nap57 and its yeast homologue Cbf5p are pseudouridine synthases involved in rRNA biogenesis, localized in the nucleolus. These proteins, together with H/ACA class of snoRNAs compose snoRNP particles, in which snoRNA guides the synthase to direct site-specific pseudouridylation of rRNA. In this paper we present an Arabidopsis thaliana protein that is highly homologous to Cbf5p (72% identity and 85% homology) and NAP57 (67% identity and 81% homology). Moreover, the plant protein has conserved structural motifs that are characteristic features of pseudouridine synthases of the TruB class. We have named the cloned and characterized protein AtNAP57 (Arabidopsis thaliana homologue of NAP57). AtNAP57 is a 565 amino-acid protein and its calculated molecular mass is 63 kDa. The protein is encoded by a single copy gene located on chromosome 3 of the A. thaliana genome. Interestingly, the AtNAP57 gene does not contain any introns. Mutations in the human DKC1 gene encoding dyskerin (human homologue of yeast Cbf5p and rat NAP57) cause dyskeratosis congenita a rare inherited bone marrow failure syndrome characterized by abnormal skin pigmentation, nail dystrophy and mucosal leukoplakia.

  5. The Synthesis Map Is a Multidimensional Educational Tool That Provides Insight into Students' Mental Models and Promotes Students' Synthetic Knowledge Generation

    Science.gov (United States)

    Ortega, Ryan A.; Brame, Cynthia J.

    2015-01-01

    Concept mapping was developed as a method of displaying and organizing hierarchical knowledge structures. Using the new, multidimensional presentation software Prezi, we have developed a new teaching technique designed to engage higher-level skills in the cognitive domain. This tool, synthesis mapping, is a natural evolution of concept mapping,…

  6. CBF and CMRo/sub 2/ during craniotomy for small supratentorial cerebral tumours in enflurane anaesthesia. A dose-response study

    Energy Technology Data Exchange (ETDEWEB)

    Madsen, J.B.; Cold, G.E.; Eriksen, H.O.; Eskesen, V.; Blatt-Lyon, B.

    1986-01-01

    In 14 patients with supratentorial cerebral tumors with midline shift less than or equal to 10 mm, cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRo/sub 2/) were measured twice on the contralateral side of the craniotomy, using a modification of the Kety and Schmidt method. For induction of anaesthesia, thiopental, fentanyl and pancuronium were used. The anaesthesia was maintained with enflurane 1% in nitrous oxide 67%. Moderate hypocapnia to a level averaging 4.3 kPa was achieved. The patients were divided into two groups. In group 1 (n=7), 1% enflurane was used throughout the anaesthesia, and CBF and CMRo/sub 2/ measured about 70 min after induction averaged 30.1 ml 100 g/sup -1/ min/sub -1/ and 1.98 ml O/sub 2/ 100 g/sup -1/ min/sup -1/, respectively. During the second CBF study 1 h later, CBF and CMRo/sub 2/ were unchanged (P>0.05). In group 2 (n=7), the inspiratory enflurane concentration was increased from 1 to 2% after the first CBF measurement. In this group a significant decrease in CMRo/sub 2/ was observed, while CBF was unchanged. In six patients EEG was recorded simultaneously with the CBF measurements. In patients subjected to increasing enflurane concentration (Group 2), a suppression in the EEG activity was observed without spike waves. It is concluded that enflurane induces a dose-related decrease in CMRo/sub 2/ and suppression in the EEG activity, whereas CBF was unchanged.

  7. CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing

    International Nuclear Information System (INIS)

    We have reported that PAP-1, a product of a causative gene for autosomal retinitis pigmentosa, plays a role in splicing. In this study, CIR, a protein originally identified as a CBF1-interacting protein and reported to act as a transcriptional corepressor, was identified as a PAP-1 binding protein and its function as a splicing factor was investigated. In addition to a basic lysine and acidic serine-rich (BA) domain and a zinc knuckle-like motif, CIR has an arginine/serine dipeptide repeat (RS) domain in its C terminal region. The RS domain has been reported to be present in the superfamily of SR proteins, which are involved in splicing reactions. We generated CIR mutants with deletions of each BA and RS domain and studied their subcellular localizations and interactions with PAP-1 and other SR proteins, including SC35, SF2/ASF, and U2AF35. CIR was found to interact with U2AF35 through the BA domain, with SC35 and SF2/ASF through the RS domain, and with PAP-1 outside the BA domain in vivo and in vitro. CIR was found to be colocalized with SC35 and PAP-1 in nuclear speckles. Then the effect of CIR on splicing was investigated using the E1a minigene as a reporter in HeLa cells. Ectopic expression of CIR with the E1a minigene changed the ratio of spliced isoforms of E1a that were produced by alternative selection of 5'-splice sites. These results indicate that CIR is a member of the family of SR-related proteins and that CIR plays a role in splicing regulation

  8. CBF mediates adenovirus Ela trans-activation by interaction at the C-terminal promoter targeting domain of conserved region 3.

    Science.gov (United States)

    Agoff, S N; Wu, B

    1994-12-01

    Genetic and biochemical evidence suggest that conserved region 3 (CR3) of the adenovirus Ela polypeptide can provide two distinct and separable functions: an N-terminal transcriptional activation region and a C-terminal promoter targeting region. It is thought that the promoter targeting region of Ela CR3 interacts with promoter-specific transcription factors, thereby bringing the activation region of Ela CR3 in proximity of the promoter. Here we report that CBF, a CCAAT-box-binding factor that regulates hsp70 gene expression and mediates Ela trans-activation in vivo, interacts with the promoter targeting region of Ela CR3 in vitro. Point mutations in Ela CR3 that are defective in stimulating transcription from the hsp70 promoter are also defective in stimulating transcription directed by a synthetic activator, GAL-CBF, composed of the DNA-binding domain of yeast GAL4 fused to CBF. These mutations fall into two classes with respect to their abilities to interact with CBF in vitro. Mutations in the transcriptional activation region of Ela CR3 do not affect binding to CBF, but mutation of the promoter targeting region of Ela CR3 prevents association with CBF in vitro.

  9. Pig brain stereotaxic standard space: mapping of cerebral blood flow normative values and effect of MPTP-lesioning

    DEFF Research Database (Denmark)

    Andersen, F; Watanabe, Hideaki; Bjarkam, Carsten;

    2005-01-01

    of minipig brain, we calculated cerebral blood flow (CBF) maps from normal minipigs and from minipigs with a syndrome of parkisonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-poisoning. These maps were transformed from the native space into the common stereotaxic space. After global...

  10. The Synthesis Map Is a Multidimensional Educational Tool That Provides Insight into Students’ Mental Models and Promotes Students’ Synthetic Knowledge Generation

    OpenAIRE

    Ortega, Ryan A; Brame, Cynthia J.

    2015-01-01

    Concept mapping was developed as a method of displaying and organizing hierarchical knowledge structures. Using the new, multidimensional presentation software Prezi, we have developed a new teaching technique designed to engage higher-level skills in the cognitive domain. This tool, synthesis mapping, is a natural evolution of concept mapping, which utilizes embedding to layer information within concepts. Prezi’s zooming user interface lets the author of the presentation use both depth as we...

  11. Mapping Long-Term Functional Changes in Cerebral Blood Flow by Arterial Spin Labeling

    Science.gov (United States)

    Ssali, Tracy; Anazodo, Udunna C.; Bureau, Yves; MacIntosh, Bradley J.; Günther, Matthias; St. Lawrence, Keith

    2016-01-01

    Although arterial spin labeling (ASL) is appealing for mapping long-term changes in functional activity, inter-sessional variations in basal blood flow, arterial transit times (ATTs), and alignment errors, can result in significant false activation when comparing images from separate sessions. By taking steps to reduce these sources of noise, this study assessed the ability of ASL to detect functional CBF changes between sessions. ASL data were collected in three sessions to image ATT, resting CBF and CBF changes associated with motor activation (7 participants). Activation maps were generated using rest and task images acquired in the same session and from sessions separated by up to a month. Good agreement was found when comparing between-session activation maps to within-session activation maps with only a 16% decrease in precision (within-session: 90 ± 7%) and a 13% decrease in the Dice similarity (within-session: 0.75 ± 0.07) coefficient after a month. In addition, voxel-wise reproducibility (within-session: 4.7 ± 4.5%) and reliability (within-session: 0.89 ± 0.20) of resting grey-matter CBF decreased by less than 18% for the between-session analysis relative to within-session values. ATT variability between sessions (5.0 ± 2.7%) was roughly half the between-subject variability, indicating that its effects on longitudinal CBF were minimal. These results demonstrate that conducting voxel-wise analysis on CBF images acquired on different days is feasible with only modest loss in precision, highlighting the potential of ASL for longitudinal studies. PMID:27706218

  12. Simultaneous CT measurement of inspired and expired gas methods of Xe-inhalation CT 1CBF study

    International Nuclear Information System (INIS)

    Our new method of xenon (Xe) CT lCBF study and the clinical results are presented. In our technique, inspiratory and expiratory tubes are closely scanned, together with the patient's head, to ascertain the Xe concentration of the arterial blood and of the brain tissue. The lCBF is then calculated from the two time-density curves, (C(exp)t) for the former and (C(t)t) for the later. In this method, a mass spectrometer is not necessary in ascertaining the time-density curve of the Xe concentration of arterial blood (C(a)t), and alternating C(exp)t to C(a)t is done only by means of the patient's Ht (%), without any sampling of arterial blood. However, the C(exp)t is not accurately reflected in the Xe concentration of the endotidal expired gas (C(end)t), and so it is necessary to correct the C(exp)t to C(end)t. It was found, from the expiratory lung model and the theoretical simulations, that each point on the C(exp)t was situated at the middle point between C(end)t and the Xe concentration of the inspired tube (C(insp)t). Therefore, the calculation was done as follows: C(end)t = 2C(exp)t - C(insp)t. The K value obtained by this method well fit the K value calculated from the C(t)t and C(end)t obtained by means of a mass spectrometer. Our new method of Xe CT lCBF study is discussed with regard to the correction of C(exp)t to C(a)t, and some clinical cases are presented. (author)

  13. Development of the Chinese Big Five Personality Inventory(CBF-PI) Ⅲ:Psychometric Properties of CBF-PI Brief Version%中国大五人格问卷的初步编制Ⅲ:简式版的制定及信效度检验

    Institute of Scientific and Technical Information of China (English)

    王孟成; 戴晓阳; 姚树桥

    2011-01-01

    Objective: The present study aimed to create a brief inventory (CBF-PI-B) to assess the five dimensions based on Chinese Big Five Personality Inventory (CBF-PI).Methods: A set of good items were extracted from CBF-PI to form a brief scale.A total of 1221 college students were administered the CBF-PI.Other two samples including 54 and 53 college students completed both CBF-PI and NEO-PI-R or BFI, respectively.Results: ①CBF-PI-B included 40 items,which had good psychometric properties.Internal consistency reliabilities (Coefficient Alphas) of the CBF-PI-B ranging from 0.764(A) to 0.814(N); the mean was 0.793.②The test-retest reliabilities 10 weeks after were also excellent, ranging from 0.672 (A) to 0.811 (O); the mean was 0.742.③The CBF-PI brief version had clear factor structure.All items loaded above 0.40 on their intended factor.Five factors explained 43.49% of the total variance, and the variance explained by each factor at the same level, ranging from 8.16% to 9.15%.Equivalence coefficients between the CBF-PI and CBF-PI-B were above 0.85.④The factors of CBF-PI-B correlated strongly with relevant dimensions of NEO-PI-R and BFI, ranging from 0.358(A) to 0.846(C) and 0.584(A) to 0.826(N), respectively.Conclusion: CBF-PI-B has good psychometric properties, which could bo employed to relevant research.%目的:在中国大五人格问卷(CBF-PI)的基础上编制中国大五人格问卷简式版(Chinese Big Five PersonalityInventory brief version,CBF-PI-B ).方法:从CBF-PI中抽取部分条目组成测量大五人格维度的简式量表.结果:①CBF-PI-B含有40个条目,每个维度分别由8个条目测量;②简式版量表各维度具有较好的信度系数,内部一致性系数在0.764(宜人性)~0.814(神经质)之间,平均0.793;间隔10周的重测系数在0.672(宜人性)~0.811(开放性)之间,平均0.742.③简式版五因子结构较为清晰共可解释总方差变异的43.49%,各因子与完整版量表对应因子的相关均在0

  14. Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage

    DEFF Research Database (Denmark)

    Ansar, Saema; Vikman, Petter; Nielsen, Marianne;

    2007-01-01

    We hypothesize that cerebral ischemia leads to enhanced expression of endothelin (ET), 5-hydroxytryptamine (5-HT), and angiotensin II (ANG II) receptors in the vascular smooth muscle cells. Our aim is to correlate the upregulation of cerebrovascular receptors and the underlying molecular mechanisms...... with the reduction in regional and global cerebral blood flow (CBF) after subarachnoid hemorrhage (SAH). SAH was induced by injecting 250 microl blood into the prechiasmatic cistern in rats. The cerebral arteries were removed 0, 1, 3, 6, 12, 24, and 48 h after the SAH for functional and molecular studies...

  15. Delayed reflow of an ischemic infarct after spontaneous thrombolysis studied by CBF tomography using SPECT and Tc-99m HMPAO

    DEFF Research Database (Denmark)

    Companioni, J M; Lassen, N A; Tfelt-Hansen, P;

    1991-01-01

    ) that allows to keep the radioactivity dose per study at 10 mCi (370 MBq). Transcranial Doppler and angiography showed spontaneous disappearance of the middle cerebral artery occlusion between days 5 and 8, while CBF showed reperfusion of the borderzone with flow increasing over several days after resolution...... of the occlusion with flows reaching levels above that of the opposite non-affected side ("Luxury Perfusion"). The delayed reflow implies, that SPECT may not constitute a reliable tool for evaluating the success or failure of thrombolytic treatment in ischemic stroke....

  16. A synthetic rainbow trout linkage map provides new insights into the salmonid whole genome duplication and the conservation of synteny among teleosts

    Directory of Open Access Journals (Sweden)

    Guyomard René

    2012-03-01

    Full Text Available Abstract Background Rainbow trout is an economically important fish and a suitable experimental organism in many fields of biology including genome evolution, owing to the occurrence of a salmonid specific whole-genome duplication (4th WGD. Rainbow trout is among some of the most studied teleosts and has benefited from substantial efforts to develop genomic resources (e.g., linkage maps. Here, we first generated a synthetic map by merging segregation data files derived from three independent linkage maps. Then, we used it to evaluate genome conservation between rainbow trout and three teleost models, medaka, stickleback and zebrafish and to further investigate the extent of the 4th WGD in trout genome. Results The INRA linkage map was updated by adding 211 new markers. After standardization of marker names, consistency of marker assignment to linkage groups and marker orders was checked across the three different data sets and only loci showing consistent location over all or almost all of the data sets were kept. This resulted in a synthetic map consisting of 2226 markers and 29 linkage groups spanning over 3600 cM. Blastn searches against medaka, stickleback, and zebrafish genomic databases resulted in 778, 824 and 730 significant hits respectively while blastx searches yielded 505, 513 and 510 significant hits. Homology search results revealed that, for most rainbow trout chromosomes, large syntenic regions encompassing nearly whole chromosome arms have been conserved between rainbow trout and its closest models, medaka and stickleback. Large conserved syntenies were also found between the genomes of rainbow trout and the reconstructed teleost ancestor. These syntenies consolidated the known homeologous affinities between rainbow trout chromosomes due to the 4th WGD and suggested new ones. Conclusions The synthetic map constructed herein further highlights the stability of the teleost genome over long evolutionary time scales. This map can be

  17. One-year follow-up of neuropsychology, MRI, rCBF and glucose metabolism (rMRGlu) in cerebral microangiopathy

    Energy Technology Data Exchange (ETDEWEB)

    Sabri, O.; Hellwig, D.; Schreckenberger, M.; Kaiser, H.-J.; Wagenknecht, G.; Setani, K.; Reinartz, P.; Zimny, M.; Buell, U. [Department of Nuclear Medicine, Technische Univ. Aachen (Germany); Schneider, R. [Department of Neurology, Technische Univ. Aachen (Germany); Mull, M. [Department of Neuroradiology, Technische Univ. Aachen (Germany); Ringelstein, E.-B. [Department of Neurology, Muenster Univ. (Germany)

    2000-07-01

    Background: MRI shows lacunar infarctions (LI), deep white matter lesions (DWML) and atrophy in cerebral microangiopathy, which is said to lead to vascular dementia. In a first trial series on 57 patients with confirmed pure cerebral microangiopathy (without concomitant macroangiopathy), neuropsychological impairment and (where present) brain atrophy correlated with decreased rCBF and rMRGlu. LI and DWML did not correlate with either neuropsychological impairment or decreased rCBF/rMRGlu. This study was done one year later to detect changes in any of the study parameters. Methods: 26 patients were re-examined for rCBF, rMRGlu, LI, DWML, atrophy and neuropsychological performance (7 cognitive, 3 mnestic, 4 attentiveness tests). Using a special head holder for exact repositioning, rCBF (SPECT) and rMRGlu (PET) were measured and imaged slice by slice. White matter/cortex were quantified using MRI-defined ROIs. Results: After one year the patients did not show significant decreases in rCBF or rMRGlu either in cortex or in white matter (p>0.05), nor did any patient show LI, DWML or atrophy changes on MRI. There were no significant neuropsychological decreases (p>0.05). (orig.) [German] Ziel: In der MRT zeigen sich bei zerebraler Mikroangiopathie (ZMA) lakunaere Infarkte (LI), Deep White Matter Lesions (DWML) und Atrophie (Atr). Die sogenannte vaskulaere Demenz wurde dabei hauptsaechlich auf die Laesionen der weissen Substanz zurueckgefuehrt. In einer ersten Untersuchungsreihe waren bei 57 Patienten mit gesicherter ZMA nur neuropsychologische Defizite (Nps) und, falls vorhanden, Atr als Grundlage fuer erniedrigte rCBF/rMRGlu-Werte zu eruieren, jedoch nicht LI/DWML. Es sollte geklaert werden, ob sich im Verlauf der Erkrankung nach einem Jahr Veraenderungen dieser Parameter ergeben. Methode: 26 Patienten wurden nach einem Jahr erneut neuropsychologisch untersucht (7 kognitive, 3 mnestrische, 4 Aufmerksamkeitstests). Mittels eines speziellen Kopfhalterungssystems wurden in

  18. New insights into eruptive activity and lava flow hazard at Nyamulagira volcano, D.R.C., from a new GIS-based lava flow map

    Science.gov (United States)

    Smets, B.; Kervyn, M.; Kervyn, F.; D'Oreye, N.; Wauthier, C.

    2010-12-01

    Nyamulagira, located in the western branch of the East African Rift (EAR), is Africa’s most active volcano with one eruption every 2 - 4 years. A map of Nyamulagira lava flows was produced during the 1960’s by Thonnard et al. (1965). This map, which results from the mosaicking of several aerial photographs, contains locally some geographic inaccuracies. The photo-interpretation also led in places to the discrimination of lava units not corresponding to any flow boundaries in the field. Finally, 19 eruptions occurred since this first edition, which causes it to be outdated and of limited use to document the recent eruptive history. Recently, Smets et al. (2010) have produced a new map of lava flows using a combination of optical and radar satellite imagery. This map is GIS-based and can be quickly updated during/after each eruption. Using the new lava flow map of Nyamulagira and a compilation of bibliographic/field information of the last 31 eruptions, the evolution of eruptive activity since the early 1900’s was reconstructed and the volume of erupted lava estimated for each eruption from 1938 to 2010. The spatio-temporal evolution of eruptive activity suggests a strong control from the rift tectonics but also from inherited basement structures on the location, the fissure orientation and the relative lava volume for the successive eruptions. The time lapse after each eruption is strongly correlated with the erupted volume of lava. The 1938-40 eruption is a key event in the volcano recent history, as the corresponding caldera collapse led to an increase of flank eruptions. Nyamulagira flank eruptions systematically destroy large areas of the protected forest of the Virunga National Park, a UNESCO World Heritage in danger since 1994. The lava flows from distal eruptions or from exceptionally high effusion rate or volume events also threaten local population, mainly south of the main edifice near Lake Kivu.

  19. Non-Invasive Estimation of Left Atrial Dominant Frequency in Atrial Fibrillation from Different Electrode Sites: Insight from Body Surface Potential Mapping

    OpenAIRE

    Marjan Bojarnejad; James R Blake; John Bourke; Ewan Shepherd; Alan Murray; Philip Langley

    2014-01-01

    The dominant driving sources of atrial fibrillation are often found in the left atrium, but the expression of left atrial activation on the body surface is poorly understood. Using body surface potential mapping and simultaneous invasive measurements of left atrial activation our aim was to describe the expression of the left atrial dominant fibrillation frequency across the body surface. 20 patients in atrial fibrillation were studied. The spatial distributions of the dominant atrial fib...

  20. Cis-regulatory element-based genome-wide identification of DREB1/CBF targets in Arabidopsis

    Institute of Scientific and Technical Information of China (English)

    Huan Zhao; Weizhong Liu; Yong Hu; Xianglin Liu; Yikun He

    2008-01-01

    Microarray analysis is used to identify transcriptional targets.However,the direct targets of transcription factors cannot be distin guished from indirect ones;further,genes with low-expression levels cannot be identified by this method.In the present study,we exploi the cis-element dehydration-responsive element(DRE)that is known to be responsible for the transcription of DRE binding factor](DREB1)targets in the promoter region of all Arabidopsis genes.Putative targets whose promoters contain the elements were verified by both microarray and reverse transcription-polymerase chain reaction(RT-PCR)analysis.Five new DREB 1/CBF direct targets were identified.Compared with traditional microarray analysis,our method is convenient and cost-effective for identifying the downstream targets of transcription factors.

  1. A Foreground Removal Strategy for future C[II] Intensity Mapping Experiments: Insights From Galaxies Selected by Stellar Mass and Redshift

    CERN Document Server

    Sun, Guochao; Viero, Marco P; Bock, Jamie; Bradford, C Matt; Chang, Tzu-Ching; Cheng, Yun-Ting; Cooray, Asantha; Crites, Abigail; Hailey-Dunsheath, Steve; Hunacek, Jonathon; Uzgil, Bade; Zemcov, Michael

    2016-01-01

    Intensity mapping provides a unique avenue to understand the epoch of reionization (EoR), which occurred approximately 500 million to 1 billion years after the Big Bang. The C[II] 158$\\mu$m fine-structure line is one of the brightest emission lines of typical star-forming galaxies and a promising tracer of the global star-formation activity during the epoch of reionization. However, C[II] intensity maps are contaminated by interloping CO rotational line emission ($3 \\leq J_{\\rm upp} \\leq 6$) from lower-redshift galaxies, whose total power is a function of the population's stochasticity. Here we present a model of CO contamination from foreground galaxies to guide the masking strategy of future C[II] intensity mapping experiments. The model is based on empirical measurements of the mean and scatter of the bolometric infrared luminosities, converted to CO line strengths, of galaxies at $z 8$. We find that the addition of scatter, parameterized by a log-normal distribution with $\\sigma = 0.33\\pm 0.04$\\,dex, to ...

  2. Neuropsychological functions and rCBF SPECT in Parkinson's disease patients considered candidates for deep brain stimulation

    International Nuclear Information System (INIS)

    In the present study, we examined relationships between neuropsychological functions and brain single photon emission computed tomography (SPECT) regional cerebral blood flow (rCBF) observed at presurgical evaluation for deep brain stimulation (DBS) of the subthalamic nucleus (STN) in advanced Parkinson's disease (PD) patients. Twenty advanced non-demented PD patients, candidates for DBS surgery, underwent perfusion brain SPECT study and neuropsychological assessment prior to surgery (range: 30-50 days). Patients were further assessed using the Unified Parkinson's Disease Rating Scale (UPDRS) and Hoehn and Yahr (H and Y) scale. During all assessments patients were ''on'' standard medication. NeuroGam software, which permits voxel by voxel analysis, was used to compare the brain perfusion of PD patients with a normal database adjusted for sex and age. Neuropsychological scores were compared to age, education and sex-adjusted normative databases. Our results indicated that the distribution of rCBF showed significant differences when compared to an age- and sex-adjusted normative database. We found impaired blood flow in 17 (85%) of our patients in the left prefrontal lobe, in 14 (70%) in the right prefrontal lobe and in 11 (55%) in the left frontal and right parietal lobes. Neuropsychological testing revealed that 18 (90%) of our patients had significant impairments in measures of executive functions (set-shifting) and 15 (75%) in response inhibition. Furthermore, we found significant correlations between measures of visual attention, executive functions and the right frontal lobe region. The presence of widespread blood flow reduction was observed mainly in the frontal lobes of dementia-free patients with advanced PD. Furthermore, performance on specific cognitive measures was highly related to perfusion brain SPECT findings. (orig.)

  3. Molecular cloning and functional characterization of a DREB1/CBF-like gene (GhDREB1L) from cotton

    Institute of Scientific and Technical Information of China (English)

    HUANG Bo; JIN LongGuo; LIU JinYuan

    2007-01-01

    The transcription factors DREB1s/CBFs play important roles in the regulation of plant resistance to environmental stresses and are quite useful for generating transgenic plants tolerant to these stresses. In the present work, a cDNA encoding DREB1/CBF-like protein (GhDREB1L) from cotton was isolated, and its sequence features, DNA binding preference, and expression patterns of the transcripts were also characterized. GhDREB1L contained one conserved AP2/ERF domain and its amino acid sequence was similar to the DREB1/CBF group of the DREB family from other plants. The DNA-binding domain of GhDREB1L was successfully expressed as a fusion protein in Escherichia coli BL21 (DE3) and purified by Ni-NTA affinity chromatography. Electrophoretic mobility shift assay revealed that the purified GhDREB1L fusion protein had a specific binding activity with the previously characterized DRE element (core sequence, ACCGAC) and also with the DRE-like sequence (core sequence, GCCGAC) in the promoter of the dehydration-responsive late embryogenesis-abundant gene LEA D113. Semi-quantita- tive RT-PCR showed that GhDREB1L was induced in the cotton cotyledons by low temperature, as well as drought and NaCl treatments. These results suggested that the novel cotton GhDREB1L might play an important role in response to low temperature as well as drought and high salinity through binding to the DRE cis-element.

  4. Neuropsychological functions and rCBF SPECT in Parkinson's disease patients considered candidates for deep brain stimulation

    Energy Technology Data Exchange (ETDEWEB)

    Paschali, Anna; Lakiotis, Velissarios; Vassilakos, Paulos [University of Patras Medical School, Department of Nuclear Medicine, Patras (Greece); Messinis, Lambros; Lyros, Epameinondas; Papathanasopoulos, Panagiotis [University of Patras Medical School, Department of Neurology, Neuropsychology Section, Patras (Greece); Constantoyannis, Costas; Kefalopoulou, Zinovia [University of Patras Medical School, Department of Neurosurgery, Patras (Greece)

    2009-11-15

    In the present study, we examined relationships between neuropsychological functions and brain single photon emission computed tomography (SPECT) regional cerebral blood flow (rCBF) observed at presurgical evaluation for deep brain stimulation (DBS) of the subthalamic nucleus (STN) in advanced Parkinson's disease (PD) patients. Twenty advanced non-demented PD patients, candidates for DBS surgery, underwent perfusion brain SPECT study and neuropsychological assessment prior to surgery (range: 30-50 days). Patients were further assessed using the Unified Parkinson's Disease Rating Scale (UPDRS) and Hoehn and Yahr (H and Y) scale. During all assessments patients were ''on'' standard medication. NeuroGam software, which permits voxel by voxel analysis, was used to compare the brain perfusion of PD patients with a normal database adjusted for sex and age. Neuropsychological scores were compared to age, education and sex-adjusted normative databases. Our results indicated that the distribution of rCBF showed significant differences when compared to an age- and sex-adjusted normative database. We found impaired blood flow in 17 (85%) of our patients in the left prefrontal lobe, in 14 (70%) in the right prefrontal lobe and in 11 (55%) in the left frontal and right parietal lobes. Neuropsychological testing revealed that 18 (90%) of our patients had significant impairments in measures of executive functions (set-shifting) and 15 (75%) in response inhibition. Furthermore, we found significant correlations between measures of visual attention, executive functions and the right frontal lobe region. The presence of widespread blood flow reduction was observed mainly in the frontal lobes of dementia-free patients with advanced PD. Furthermore, performance on specific cognitive measures was highly related to perfusion brain SPECT findings. (orig.)

  5. Molecular cloning and functional characterization of a DREB1/CBF-like gene (GhDREB1L) from cotton

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The transcription factors DREB1s/CBFs play important roles in the regulation of plant resistance to environmental stresses and are quite useful for generating transgenic plants tolerant to these stresses. In the present work, a cDNA encoding DREB1/CBF-like protein (GhDREB1L) from cotton was isolated, and its sequence features, DNA binding preference, and expression patterns of the transcripts were also characterized. GhDREB1L contained one conserved AP2/ERF domain and its amino acid sequence was similar to the DREB1/CBF group of the DREB family from other plants. The DNA-binding domain of GhDREB1L was successfully expressed as a fusion protein in Escherichia coli BL21 (DE3) and purified by Ni-NTA affinity chromatography. Electrophoretic mobility shift assay revealed that the purified GhDREB1L fusion protein had a specific binding activity with the previously characterized DRE ele-ment (core sequence, ACCGAC) and also with the DRE-like sequence (core sequence, GCCGAC) in the promoter of the dehydration-responsive late embryogenesis-abundant gene LEA D113. Semi-quantita- tive RT-PCR showed that GhDREB1L was induced in the cotton cotyledons by low temperature, as well as drought and NaCl treatments. These results suggested that the novel cotton GhDREB1L might play an important role in response to low temperature as well as drought and high salinity through binding to the DRE cis-element.

  6. Melatonin induces the transcripts of CBF/DREB1s and their involvement in both abiotic and biotic stresses in Arabidopsis.

    Science.gov (United States)

    Shi, Haitao; Qian, Yongqiang; Tan, Dun-Xian; Reiter, Russel J; He, Chaozu

    2015-10-01

    Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring small molecule that acts as an important secondary messenger in plant stress responses. However, the mechanism underlying the melatonin-mediated signaling pathway in plant stress responses has not been established. C-repeat-binding factors (CBFs)/Drought response element Binding 1 factors (DREB1s) encode transcription factors that play important roles in plant stress responses. This study has determined that endogenous melatonin and transcripts level of CBFs (AtCBF1, AtCBF2, and AtCBF3) in Arabidopsis leaves were significantly induced by salt, drought, and cold stresses and by pathogen Pseudomonas syringe pv. tomato (Pst) DC3000 infection. Moreover, both exogenous melatonin treatment and overexpression of CBFs conferred enhanced resistance to both abiotic and biotic stresses in Arabidopsis. Notably, AtCBFs and exogenous melatonin treatment positively regulated the mRNA expression of several stress-responsive genes (COR15A, RD22, and KIN1) and accumulation of soluble sugars content such as sucrose in Arabidopsis under control and stress conditions. Additionally, exogenous sucrose also conferred improved resistance to both abiotic and biotic stresses in Arabidopsis. Taken together, this study indicates that AtCBFs confer enhanced resistance to both abiotic and biotic stresses, and AtCBF-mediated signaling pathway and sugar accumulation may be involved in melatonin-mediated stress response in Arabidopsis, at least partially.

  7. Melatonin induces the transcripts of CBF/DREB1s and their involvement in both abiotic and biotic stresses in Arabidopsis.

    Science.gov (United States)

    Shi, Haitao; Qian, Yongqiang; Tan, Dun-Xian; Reiter, Russel J; He, Chaozu

    2015-10-01

    Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring small molecule that acts as an important secondary messenger in plant stress responses. However, the mechanism underlying the melatonin-mediated signaling pathway in plant stress responses has not been established. C-repeat-binding factors (CBFs)/Drought response element Binding 1 factors (DREB1s) encode transcription factors that play important roles in plant stress responses. This study has determined that endogenous melatonin and transcripts level of CBFs (AtCBF1, AtCBF2, and AtCBF3) in Arabidopsis leaves were significantly induced by salt, drought, and cold stresses and by pathogen Pseudomonas syringe pv. tomato (Pst) DC3000 infection. Moreover, both exogenous melatonin treatment and overexpression of CBFs conferred enhanced resistance to both abiotic and biotic stresses in Arabidopsis. Notably, AtCBFs and exogenous melatonin treatment positively regulated the mRNA expression of several stress-responsive genes (COR15A, RD22, and KIN1) and accumulation of soluble sugars content such as sucrose in Arabidopsis under control and stress conditions. Additionally, exogenous sucrose also conferred improved resistance to both abiotic and biotic stresses in Arabidopsis. Taken together, this study indicates that AtCBFs confer enhanced resistance to both abiotic and biotic stresses, and AtCBF-mediated signaling pathway and sugar accumulation may be involved in melatonin-mediated stress response in Arabidopsis, at least partially. PMID:26182834

  8. Integration of new geologic mapping and satellite-derived quartz mapping yields insights into the structure of the Roberts Mountains allochthon applicable to assessments for concealed Carlin-type gold deposits

    Science.gov (United States)

    Holm-Denoma, Christopher S.; Hofstra, Albert H.; Rockwell, Barnaby W.; Noble, Paula J.

    2012-01-01

    Geologic mapping and remote sensing across north-central Nevada enable recognition of a thick sheet of Middle and Upper Ordovician Valmy Formation quartzite that structurally overlies folded and faulted Ordovician through Devonian stratigraphic units of the Roberts Mountains allochthon. In the northern Independence Mountains and nearby Double Mountain area, the Valmy Formation is in fault contact with Ordovician through Silurian, predominantly clastic, sedimentary rocks of the Roberts Mountains allochthon that were deformed prior to, or during, emplacement of the Valmy thrust sheet. Similar structural relations are recognized discontinuously for 200 kilometers along the strike of the Roberts Mountains allochthon in mapping guided by regional remote-sensing-based (ASTER) quartz maps. Overall thicknesses of deformed Roberts Mountains allochthon units between the base of the Valmy and the top of underlying carbonate rocks that host large Carlin-type gold deposits varies on the order of hundreds of meters but is not known to exceed 700 meters. The base of the Valmy thrust sheet is a complimentary datum in natural resource exploration and mineral resource assessment for concealed Carlin-type gold deposits.

  9. Genome-wide analysis of the AP2/ERF family in Eucalyptus grandis: an intriguing over-representation of stress-responsive DREB1/CBF genes.

    Directory of Open Access Journals (Sweden)

    P B Cao

    Full Text Available The AP2/ERF family includes a large number of developmentally and physiologically important transcription factors sharing an AP2 DNA-binding domain. Among them DREB1/CBF and DREB2 factors are known as master regulators respectively of cold and heat/osmotic stress responses.The manual annotation of AP2/ERF family from Eucalyptus grandis, Malus, Populus and Vitis genomes allowed a complete phylogenetic study for comparing the structure of this family in woody species and the model Arabidopsis thaliana. Expression profiles of the whole groups of EgrDREB1 and EgrDREB2 were investigated through RNAseq database survey and RT-qPCR analyses.The structure and the size of the AP2/ERF family show a global conservation for the plant species under comparison. In addition to an expansion of the ERF subfamily, the tree genomes mainly differ with respect to the group representation within the subfamilies. With regard to the E. grandis DREB subfamily, an obvious feature is the presence of 17 DREB1/CBF genes, the maximum reported to date for dicotyledons. In contrast, only six DREB2 have been identified, which is similar to the other plants species under study, except for Malus. All the DREB1/CBF and DREB2 genes from E. grandis are expressed in at least one condition and all are heat-responsive. Regulation by cold and drought depends on the genes but is not specific of one group; DREB1/CBF group is more cold-inducible than DREB2 which is mainly drought responsive.These features suggest that the dramatic expansion of the DREB1/CBF group might be related to the adaptation of this evergreen tree to climate changes when it expanded in Australia.

  10. Xenon computed tomographic blood flow mapping

    International Nuclear Information System (INIS)

    Xenon CT flow information appears to be clinically useful in the diagnosis and management of a broad spectrum of clinical disorders. It also appears to be a useful tool for the experimental study of the cerebral circulation, with recent work also extending to application to the study of solid abdominal organs. The authors therefore found xenon CT CBF mapping to be a useful new blood flow methodology and are of the opinion that as CT technology improves, one will be able to obtain still better flow information with less accompanying radiation exposure and/or a reduction in the level of xenon inhalation required

  11. Metabolic profiling of a mapping population exposes new insights in the regulation of seed metabolism and seed, fruit, and plant relations.

    Directory of Open Access Journals (Sweden)

    David Toubiana

    Full Text Available To investigate the regulation of seed metabolism and to estimate the degree of metabolic natural variability, metabolite profiling and network analysis were applied to a collection of 76 different homozygous tomato introgression lines (ILs grown in the field in two consecutive harvest seasons. Factorial ANOVA confirmed the presence of 30 metabolite quantitative trait loci (mQTL. Amino acid contents displayed a high degree of variability across the population, with similar patterns across the two seasons, while sugars exhibited significant seasonal fluctuations. Upon integration of data for tomato pericarp metabolite profiling, factorial ANOVA identified the main factor for metabolic polymorphism to be the genotypic background rather than the environment or the tissue. Analysis of the coefficient of variance indicated greater phenotypic plasticity in the ILs than in the M82 tomato cultivar. Broad-sense estimate of heritability suggested that the mode of inheritance of metabolite traits in the seed differed from that in the fruit. Correlation-based metabolic network analysis comparing metabolite data for the seed with that for the pericarp showed that the seed network displayed tighter interdependence of metabolic processes than the fruit. Amino acids in the seed metabolic network were shown to play a central hub-like role in the topology of the network, maintaining high interactions with other metabolite categories, i.e., sugars and organic acids. Network analysis identified six exceptionally highly co-regulated amino acids, Gly, Ser, Thr, Ile, Val, and Pro. The strong interdependence of this group was confirmed by the mQTL mapping. Taken together these results (i reflect the extensive redundancy of the regulation underlying seed metabolism, (ii demonstrate the tight co-ordination of seed metabolism with respect to fruit metabolism, and (iii emphasize the centrality of the amino acid module in the seed metabolic network. Finally, the study

  12. Structural Controls of the MacFarlane Geothermal System, Humboldt County, Nevada: New Insights Based on Detailed Geologic Mapping, Shallow Temperature Surveys, and Magnetic Data

    Science.gov (United States)

    Kraushaar, Sabina M.

    Detailed geologic mapping, structural analysis, magnetic and two-meter temperature data, integrated with previous datasets, constrain the structural controls of the MacFarlane geothermal system. MacFarlane hot springs and the travertine fissure ridges lie within a relay ramp. The relay ramp is formed between two overlapping, north-northeast-striking, west-dipping Holocene normal faults exposed in Lake Lahontan sediments. Other mapped faults near the hot spring include a north-striking, west-dipping Tertiary fault east of MacFarlane hot springs. The highest temperature gradient is found at the projected intersection between the Tertiary and north-northeast-striking Quaternary fault, ˜2.5 km northeast of the hot spring (Sibbett et al., 1982; Swanberg and Bowers, 1982). Our new data suggest other controls involving the relay ramp geometry of the Holocene faults. The anomalous orientation of the travertine fissure ridge motivated this study of the structural controls of the geothermal system. MacFarlane hot spring is located on the eastern margin of the Black Rock Desert, ˜85 km west of Winnemucca, in Humboldt County, Nevada. The active hot spring emerges from the west end of an east-trending travertine fissure ridge, which is ˜180 m long. The travertine fissure ridge is up to ˜2 m tall and ˜5 m wide, and has a central fissure along its long axis. The orientation of the travertine fissure ridge indicates local north-south extension, which is inconsistent with the regional west-northwest extension of the northwestern Basin and Range province. The anomalous travertine orientation is due to fractures that occurred during formation of a relay ramp between two overlapping fault segments.

  13. Genetic mapping of QTLs controlling fatty acids provided insights into the genetic control of fatty acid synthesis pathway in peanut (Arachis hypogaea L..

    Directory of Open Access Journals (Sweden)

    Ming Li Wang

    Full Text Available Peanut, a high-oil crop with about 50% oil content, is either crushed for oil or used as edible products. Fatty acid composition determines the oil quality which has high relevance to consumer health, flavor, and shelf life of commercial products. In addition to the major fatty acids, oleic acid (C18:1 and linoleic acid (C18:2 accounting for about 80% of peanut oil, the six other fatty acids namely palmitic acid (C16:0, stearic acid (C18:0, arachidic acid (C20:0, gadoleic acid (C20:1, behenic acid (C22:0, and lignoceric acid (C24:0 are accounted for the rest 20%. To determine the genetic basis and to improve further understanding on effect of FAD2 genes on these fatty acids, two recombinant inbred line (RIL populations namely S-population (high oleic line 'SunOleic 97R' × low oleic line 'NC94022' and T-population (normal oleic line 'Tifrunner' × low oleic line 'GT-C20' were developed. Genetic maps with 206 and 378 marker loci for the S- and the T-population, respectively were used for quantitative trait locus (QTL analysis. As a result, a total of 164 main-effect (M-QTLs and 27 epistatic (E-QTLs QTLs associated with the minor fatty acids were identified with 0.16% to 40.56% phenotypic variation explained (PVE. Thirty four major QTLs (>10% of PVE mapped on five linkage groups and 28 clusters containing more than three QTLs were also identified. These results suggest that the major QTLs with large additive effects would play an important role in controlling composition of these minor fatty acids in addition to the oleic and linoleic acids in peanut oil. The interrelationship among these fatty acids should be considered while breeding for improved peanut genotypes with good oil quality and desired fatty acid composition.

  14. Core binding factor acute myeloid leukemia (CBF-AML) in México: a single institution experience.

    Science.gov (United States)

    Ruiz-Delgado, Guillermo J; Macías-Gallardo, Julio; Lutz-Presno, Julia; Garcés-Eisele, Javier; Hernández-Arizpe, Ana; Montes-Montiel, Maryel; Ruiz-Argüelles, Guillermo J

    2011-01-01

    Twenty one patients with CBF-AML presented prospectively in the Centro de Hematología y Medicina Interna de Puebla (Puebla, México) between February 1995 and March 2010, 14 with the t(8;21)(q22;q22) and 7 with the inv(16)(p13;q22)/t(16;16)(p13;q22); they represent 13% of all cases of AML. The median age of the patients was 24 years (range 1 to 61). Seven of 14 patients with t(8;21)(q22;q22) had an M2 morphology whereas 3/7 with the inv(16) had an M4 morphology; in addition to the myeloid markers identified by flow-cytometry (surface CD13, surface CD33, and cytoplasmic myeloperoxidase) lymphoid markers were identified in the blast cells of 8/14 cases of the t(8;21) patients, but in no patient with the inv(16). Nineteen patients were treated with combined chemotherapy and 16 (84%) achieved a complete molecular remission. Seven patients were auto or allografted. Relapses presented in 10/16 patients. The median probability of overall survival (OS) has not been reached being above 165 months, whereas the 165-month probability of OS and leukemia-free survival was 52%; despite a tendency for a better outcome of patients with the t(8;21), there were no significant differences in survival of patients with either the t(8;21) or the inv(16). In this single institution experience in México, we found that the CBF variants of AML have a similar prevalence as compared with Caucasian populations, that the co-expression of lymphoid markers in the blast cells was frequent in the t(8;21) and that these two AML subtypes were associated with a relatively good long-term prognosis. Further studies are needed to describe with more detail the precise biological features of these molecular subtypes of acute leukemia.

  15. High-throughput mapping of the promoters of the mouse olfactory receptor genes reveals a new type of mammalian promoter and provides insight into olfactory receptor gene regulation.

    Science.gov (United States)

    Clowney, E Josephine; Magklara, Angeliki; Colquitt, Bradley M; Pathak, Nidhi; Lane, Robert P; Lomvardas, Stavros

    2011-08-01

    The olfactory receptor (OR) genes are the largest mammalian gene family and are expressed in a monogenic and monoallelic fashion in olfactory neurons. Using a high-throughput approach, we mapped the transcription start sites of 1085 of the 1400 murine OR genes and performed computational analysis that revealed potential transcription factor binding sites shared by the majority of these promoters. Our analysis produced a hierarchical model for OR promoter recognition in which unusually high AT content, a unique epigenetic signature, and a stereotypically positioned O/E site distinguish OR promoters from the rest of the murine promoters. Our computations revealed an intriguing correlation between promoter AT content and evolutionary plasticity, as the most AT-rich promoters regulate rapidly evolving gene families. Within the AT-rich promoter category the position of the TATA-box does not correlate with the transcription start site. Instead, a spike in GC composition might define the exact location of the TSS, introducing the concept of "genomic contrast" in transcriptional regulation. Finally, our experiments show that genomic neighborhood rather than promoter sequence correlates with the probability of different OR genes to be expressed in the same olfactory cell.

  16. The active Moresby Seamount Detachment Fault, Woodlark Basin: insights into structure and mechanics from high-resolution submarine mapping and sampling

    Science.gov (United States)

    Behrmann, Jan H.; Speckbacher, Romed; Nagel, Thorsten; Klaucke, Ingo; Devey, Colin W.

    2010-05-01

    Moresby Seamount Detachment, located east of Papua New Guinea in the Woodlark Basin, is arguably the best-exposed active extensional detachment fault in the world. It forms the northern slopes of Moresby Seamount, a 3000 meter high east-west trending tectonic horst separating two extensional basins. Fault zone dip is about 30°, and total horizontal stretch accumulated in the past 3.5 Ma is about 8 km. The detachment surface is exposed on the sea floor over an area of about 30 square kilometers. Denudation is almost absent, and sedimentation is apparently suppressed by strong bottom water currents, providing a unique opportunity to analyze the tectonic geomorphology and structure of the fault zone, and sample the fault rocks. R/V SONNE Expedition 203 first mapped the area with about 20 m spatial resolution by ship-based multibeam bathymetry operating at 12 kHz. Most of the detachment surface was subsequently surveyed by AUV fitted with a 200 kHz multibeam echosounder, a CTD and a water column turbidity sensor. Map resolution is about 2 m. Samples were dredged from the detachment, and in basement and sediment sites in the footwall block. In the uppermost part the detachment zone cuts through an approximately 500 m thick sequence of Pliocene clastic sediments. Topography there is rugged, with erosional gullies, and areas of slope failure. Below, an upper smooth zone of the detachment is made up by a slope-parallel belt of cataclasites, generated from metamorphic basement rocks of Paleogene or older age, mainly gabbro, metadiabase and psammo-pelitic schists. Structurally and topographically below the cataclasites is a lower rugged zone mainly exposing cataclasites and mylonites. Topography is due to localized slope failure and a major sinistral strike slip fault scarp transecting the detachment with a 320° azimuth. Below the rugged zone is a lower smooth zone of cataclasites and mylonites. The most spectacular feature here are several north-south trending, extremely

  17. Evolution of garnet distribution, shape and composition in high-grade pelitic migmatites of Salvador da Bahia, Brazil: insights from LA-ICP-MS trace element mapping

    Science.gov (United States)

    Goncalves, Philippe; Raimondo, Tom; Santos de Souza, Jailma

    2016-04-01

    Garnet is a widely used mineral in metamorphic petrology and more particularly for thermobarometric modelling to reconstruct the P-T-t evolution of Earth's crust. This is due to its ubiquity in high grade rocks (T > 450°C), its occurrence in many assemblages of interest for thermobarometry, and mostly to its ability to preserve chemical zoning. Two types of zoning are distinguished: growth and diffusion zoning. Growth zoning reflects crystallisation coeval with changes in P-T conditions or bulk composition. This type of zoning is therefore particularly useful to unravel the P-T evolution of open systems and determine the growth mechanisms involved. However, growth zoning in major elements is commonly altered by processes such as volume diffusion, which is particularly efficient at high temperatures and for elements like Fe or Mg that have high diffusion coefficients. In such cases, information that relates to the environmental conditions of garnet growth is either totally or partially obliterated. To minimise the impact of this process on growth zoning and retain useful information, trace elements are more appropriate because of their lower diffusion coefficients compared to major elements. In this study, the distribution of trace elements in garnet has been imaged using an emerging LA-ICP-MS mapping technique. This is achieved by rastering of the focused laser beam in linear transects, which are then stitched together by post-acquisition processing to form a quantified or semi-quantified image of the trace element distribution, with excellent detection limits (ppb) over a wide isotopic range (7Li to 238U) and minimal sample preparation required. This technique has been applied to high-grade pelitic gneisses and migmatites from the Paleoproterozoic Itabuna-Salvador-Curaça belt (adjacent to the Farol da Bara, Salvador da Bahia, Brazil). Structurally, it is located in a steeply-dipping high strain zone that may have played a major role in the segregation and

  18. Coronary atheroma composition and its association with segmental endothelial dysfunction in non-ST segment elevation myocardial infarction: novel insights with radiofrequency (iMAP) intravascular ultrasonography.

    Science.gov (United States)

    Puri, Rishi; Nicholls, Stephen J; Brennan, Danielle M; Andrews, Jordan; Liew, Gary Y; Carbone, Angelo; Copus, Barbara; Nelson, Adam J; Kapadia, Samir R; Tuzcu, E Murat; Beltrame, John F; Worthley, Stephen G; Worthley, Matthew I

    2015-02-01

    Little is known of the relationship between coronary atheroma composition and corresponding endothelial dysfunction. We tested the hypothesis that segmental epicardial vasoreactivity relates to atheroma composition in patients with non-ST segment elevation myocardial infarction (NSTEMI) in vivo. In 23 NSTEMI patients referred for coronary angiography, a non-culprit vessel underwent intracoronary salbutamol (0.30 μg/min) provocation during automated IVUS pullback. A 40 MHz rotational IVUS catheter delivered radiofrequency signals at constant 67 μm intervals via a custom-built IVUS console (iMAP, iLAB, Boston Scientific). Macrovascular response [change in segmental lumen volume (SLV) at baseline and following salbutamol], percent atheroma volume (PAV) and tissue composition was evaluated in 187 contiguous non-overlapping 5 mm coronary segments. Compared with segments that dilated, constrictive segments showed similar SLV, but greater vessel volumes and PAV at baseline. The extent of necrotic and lipidic plaque was significantly greater in constrictive segments, whereas fibrotic plaque content was significantly greater in segments that dilated. Calcific plaque content did not relate to endothelium-dependent vasoreactivity. The change in SLV correlated inversely with the amount of lipidic and necrotic plaque (both r = -0.23, p = 0.002), and directly with fibrotic plaque content (r = 0.23, p = 0.002). In a multivariable model, the extent of both lipidic and necrotic plaque independently associated with segmental vasoconstriction (β = 1.2, p = 0.023; β = 0.66, p = 0.027). Following NSTEMI, both lipidic and necrotic plaque content each associate with segmental endothelial dysfunction. The link between plaque composition and vessel reactivity provides a mechanistic basis of the pathogenesis associated with vulnerable plaque in humans in vivo. PMID:25296909

  19. Mapping of the Co-Transcriptomes of UPEC-Infected Macrophages Reveals New Insights into the Molecular Basis of Host-Pathogen Interactions in Human and Mouse

    KAUST Repository

    Mavromatis, Charalampos Harris

    2014-01-01

    provides both a unique co-culture approach to study infection in vitro and a technological framework for simultaneously capturing global changes in hostpathogen interactions at the transcriptional level in co-cultures. In conclusion, this work has generated new insights into the mechanisms that UPEC strains exploit to persist within the mouse intramacrophage environment, as well as differences in the transcriptional repertoire of HMDM and BMM challenged with the same UPEC strain.

  20. Mapping South American Summer Monsoon Changes during Heinrich Event 1 and the LGM: Insights from New Paleolake Records from the Central Andes

    Science.gov (United States)

    Chen, C. Y.; McGee, D.; Quade, J.

    2015-12-01

    Cave stalagmite records show strong evidence of abrupt changes in summer monsoons during Heinrich events, but we lack rigorous constraints on the amount of wetting or drying occurring in monsoon regions. Studies on shoreline deposits of closed-basin lakes can establish quantitative bounds on water balance changes through mapping-based estimates of lake volume variations. We present new dating constraints on lake level variations in Agua Caliente I and Laguna Loyoques, two closed-basin, high-altitude paleolakes on the Altiplano-Puna plateau of the Central Andes (23.1°S, 67.4°W, 4250 masl). Because this area receives >70% of its total annual precipitation during austral summer, the region is ideally suited to capture a pure response to changes in the South American summer monsoon (SASM). The plateau is home to several small (<40 km2) lakes surrounded by well-preserved paleoshorelines that indicate past wetter conditions. Agua Caliente I is unique, having multiple shorelines encrusted with biologically-mediated calcium carbonate "tufa" deposits. Initial U-Th dating of these massive shoreline tufas reveals that these deposits are dateable to within ±50 to 300 years due to high U concentrations and low initial Th content (as indicated by high 230Th/232Th). Our U-Th dates show that Agua Caliente I was greater in lake surface area during two periods: 17.5-14.5 kyrs BP, coincident with Heinrich Event 1 (HE1), and 24-23 kyrs BP, roughly coincident with the Last Glacial Maximum (LGM). At these times, Agua Caliente I also overflowed into a neighboring lake basin (Loyoques) through an 8-km long southeast-trending stream channel. Thus, during HE1 and the LGM, the lake was ~9 times larger in surface area relative to modern. Hydrologic modeling constrained by paleotemperature estimates is used to provide bounds for these past precipitation changes. We also tentatively explore physical mechanisms linking Heinrich events and the regional hydroclimate by comparing freshwater

  1. Klonierung, Sequenzierung und Charakterisierung der genetischen Determinante des CAMP-Faktors (=cbf-Gen) der Gruppe-B-Streptokokken (Streptococcus agalactiae)

    OpenAIRE

    Blankenstein, Oliver

    2005-01-01

    The CAMP reaction, a synergistic lysis of sheep erythrocytes by Staphylococcus aureus (beta-toxin) and group B streptococci (Streptococcus agalactiae) was first described in 1944 by Christie et al.. This phenomenon is caused by the CAMP-factor, an extra-cellular protein which role pathogenicity and virulence is still unknown. The focus of this work is the molecular isolation and characterization of the CAMP-factor gene of group B streptococci (cbf-Gene). First cloning attempts were made using...

  2. Cerebral perfusion SPECT using Tc-99m-d,l-HMPAO. Comparative study with I-123 IMP and CBF measured by PET

    Energy Technology Data Exchange (ETDEWEB)

    Nishizawa, Sadahiko; Yonekura, Yoshiharu; Fujita, Tohru; Senda, Michio; Konishi, Junji; Ishikawa, Masatsune; Fukuyama, Hidenao

    1987-10-01

    To evaluate clinical usefulness of technetium-99m-d,l-hexamethylpropyleneamine oxime (HMPAO) as cerebral perfusion agent for SPECT, we compared the distribution of HMPAO with that of N-isopropyl-(I-123)p-iodoamphetamine (IMP) and regional cerebral blood flow (rCBF) measured by PET. In HMPAO study, we performed serial SPECT scans until 5 hr in 7 cases, and single SPECT scan at 5 min after the injection in the other 17 cases. Among 24 cases, IMP-SPECT was performed in 9 cases and PET was done in 17 cases. All SPECT scans were performed with multi-detecter SPECT scanner. The regional distribution of HMPAO in the brain did not show major changes visually except the lesions of meningioma and arteriovenous malformation, and the regional activity showed 1 % increase at 45 min and 4 % decrease at 5 hr compared with the activity at 5 min. In cases with cerebral infarction, major discrepancy was not observed among 3 studies. However, in cases having mild regional hypoperfusion of less than 30 % decrease in rCBF compared with the non-affected area, reduced perfusion was not clearly visualized in the HMPAO-SPECT while IMP-SPECT demonstrated the ischemic lesion with better contrast. Although HMPAO is useful to assess rCBF using SPECT with the advantage of its availability at any time, the present study raised a question about the limitation of the detectability in mild ischemia.

  3. Comparison of D2 receptor binding (123I-IBZM) and rCBF (99mTc-HMPAO) in extrapyramidal disorders

    International Nuclear Information System (INIS)

    The aim of this SPECT study was to determine whether there is a correlation between rCBF (99mTc-HMPAO) and D2 receptor binding (123I-IBZM) in disorders of the extrapyramidal system and in which situation the 99MTc-HMPAO scan could predict the outcome of the 123I-IBZM study. 13 patients with Parkinson's syndrome and 13 patients with hyperkinetic extrapyramidal disorders were studied. In all patients the two SPECT studies were performed within 2-7 days. ROIs were placed over the basal ganglia (BG), the frontal cortex (FC) and the cerebellum (CE). The ratios BG/FC and BG/CE were calculated. In both groups the scatter was lower when the frontal cortex was used as reference region. Among the patients with hyperkinetic extrapyramidal hyperkinetic extrapyramidal disorders the two patients with Huntington's chorea had lower rCBF and D2 receptor binding compared to other hyperkinetic extrapyramidal disorders. There was no correlation between D2 receptor binding and rCBF in the basal ganglia. The 99MTc-HMPAO studies did not provide clinically useful information, except in Huntington's chorea. (orig.)

  4. Comparison of xenon enhanced CT (XeCT) and I-123 iodoamphetamine (SPECT/IMP) techniques for measurement of regional cerebral blood flow (rCBF)

    International Nuclear Information System (INIS)

    An ongoing prospective study measuring rCBF by XeCT(20 patients) and SPECT/IMP (84 patients) to date includes 9 patients examined by both techniques. XeCT was done as 3 contiguous transaxial tomograms using a scanner (GE 9800) equipped with dynamic imaging capability and a gas delivery system for inspiring 30% Xenon. SPECT/IMP was done 20 minutes after injection of 3-5 mCi of IMP, obtaining 64 views over 360 degrees, 40 sec./view, with either a GE 400T or 400ACT. SPECT/IMP images obtained with the 400ACT camera (specially designed for head work) were superior to those obtained with the older camera. For all 9 cases, both techniques demonstrated flow abnormalities at all sites of infarction identified by conventional CT (TCT): 1 patient with normal TCT also had normal rCBF examinations. Furthermore, 8 of 9 cases showed evidence of ischemia (regions with normal TCT and abnormal rCBF measurements) by both techniques

  5. Redox Signaling and CBF-Responsive Pathway Are Involved in Salicylic Acid-Improved Photosynthesis and Growth under Chilling Stress in Watermelon

    Science.gov (United States)

    Cheng, Fei; Lu, Junyang; Gao, Min; Shi, Kai; Kong, Qiusheng; Huang, Yuan; Bie, Zhilong

    2016-01-01

    Salicylic acid (SA) plays an important role in plant response to abiotic stresses. This study investigated the potential role of SA in alleviating the adverse effects of chilling stress on photosynthesis and growth in watermelon (Citrullus lanatus). Chilling stress induced the simultaneous accumulation of free and conjugated SA in watermelon plants, and the chilling-induced SA production was attributed to the phenylalanine ammonia-lyase pathway. Applying SA at moderate concentrations induced chilling tolerance, whereas inhibition of SA biosynthesis by L-α-aminooxy-β-phenylpropionic acid (AOPP) increased the photooxidation of PS II under chilling stress in watermelon, resulting in reduced photosynthesis and growth. Chilling induced a transient increase in the ratios of reduced to oxidized glutathione and reduced ascorbate to dehydroascorbate. Then, the expression of antioxidant genes was upregulated, and the activities of antioxidant enzymes were enhanced. Furthermore, SA-induced chilling tolerance was associated with cellular glutathione and ascorbate homeostasis, which served as redox signals to regulate antioxidant metabolism under chilling stress. AOPP treatment stimulated the chilling-induced expression of cold-responsive genes, particularly via C-repeat binding factors CBF3 and CBF4. These results confirm the synergistic role of SA signaling and the CBF-dependent responsive pathway during chilling stress in watermelon. PMID:27777580

  6. Functional cluster analysis of CT perfusion maps: a new tool for diagnosis of acute stroke?

    Science.gov (United States)

    Baumgartner, Christian; Gautsch, Kurt; Böhm, Christian; Felber, Stephan

    2005-09-01

    CT perfusion imaging constitutes an important contribution to the early diagnosis of acute stroke. Cerebral blood flow (CBF), cerebral blood volume (CBV) and time-to-peak (TTP) maps are used to estimate the severity of cerebral damage after acute ischemia. We introduce functional cluster analysis as a new tool to evaluate CT perfusion in order to identify normal brain, ischemic tissue and large vessels. CBF, CBV and TTP maps represent the basis for cluster analysis applying a partitioning (k-means) and density-based (density-based spatial clustering of applications with noise, DBSCAN) paradigm. In patients with transient ischemic attack and stroke, cluster analysis identified brain areas with distinct hemodynamic properties (gray and white matter) and segmented territorial ischemia. CBF, CBV and TTP values of each detected cluster were displayed. Our preliminary results indicate that functional cluster analysis of CT perfusion maps may become a helpful tool for the interpretation of perfusion maps and provide a rapid means for the segmentation of ischemic tissue. PMID:15827821

  7. Dreaming and insight

    Directory of Open Access Journals (Sweden)

    Christopher L Edwards

    2013-12-01

    Full Text Available This paper addresses claims that dreams can be a source of personal insight. Whereas there has been anecdotal backing for such claims, there is now tangential support from findings of the facilitative effect of sleep on cognitive insight, and of REM sleep in particular on emotional memory consolidation. Furthermore, the presence in dreams of metaphorical representations of waking life indicates the possibility of novel insight as an emergent feature of such metaphorical mappings. In order to assess whether personal insight can occur as a result of the consideration of dream content, 11 dream group discussion sessions were conducted which followed the Ullman Dream Appreciation technique, one session for each of 11 participants (10 females, 1 male; mean age = 19.2 years. Self-ratings of deepened self-perception and personal gains from participation in the group sessions showed that the Ullman technique is an effective procedure for establishing connections between dream content and recent waking life experiences, although wake life sources were found for only 14% of dream report text. The mean Exploration-Insight score on the Gains from Dream Interpretation questionnaire was very high and comparable to outcomes from the well-established Hill (1996 therapist-led dream interpretation method. This score was associated between-subjects with pre-group positive Attitude Toward Dreams. The need to distinguish ‘aha’ experiences as a result of discovering a waking life source for part of a dream, from ‘aha’ experiences of personal insight as a result of considering dream content, is discussed. Difficulties are described in designing a control condition to which the dream report condition can be compared.

  8. Dreaming and insight.

    Science.gov (United States)

    Edwards, Christopher L; Ruby, Perrine M; Malinowski, Josie E; Bennett, Paul D; Blagrove, Mark T

    2013-01-01

    This paper addresses claims that dreams can be a source of personal insight. Whereas there has been anecdotal backing for such claims, there is now tangential support from findings of the facilitative effect of sleep on cognitive insight, and of REM sleep in particular on emotional memory consolidation. Furthermore, the presence in dreams of metaphorical representations of waking life indicates the possibility of novel insight as an emergent feature of such metaphorical mappings. In order to assess whether personal insight can occur as a result of the consideration of dream content, 11 dream group discussion sessions were conducted which followed the Ullman Dream Appreciation technique, one session for each of 11 participants (10 females, 1 male; mean age = 19.2 years). Self-ratings of deepened self-perception and personal gains from participation in the group sessions showed that the Ullman technique is an effective procedure for establishing connections between dream content and recent waking life experiences, although wake life sources were found for only 14% of dream report text. The mean Exploration-Insight score on the Gains from Dream Interpretation questionnaire was very high and comparable to outcomes from the well-established Hill (1996) therapist-led dream interpretation method. This score was associated between-subjects with pre-group positive Attitude Toward Dreams (ATD). The need to distinguish "aha" experiences as a result of discovering a waking life source for part of a dream, from "aha" experiences of personal insight as a result of considering dream content, is discussed. Difficulties are described in designing a control condition to which the dream report condition can be compared. PMID:24550849

  9. Quantitative kinetic analysis of PET amyloid imaging agents [11C]BF227 and [18F]FACT in human brain

    International Nuclear Information System (INIS)

    Introduction: The purpose of this study was to compare two amyloid imaging agents, [11C]BF227 and [18F]FACT (derivative from [11C]BF227) through quantitative pharmacokinetics analysis in human brain. Methods: Positron emission tomography studies were performed on six elderly healthy control (HC) subjects and seven probable Alzheimer’s disease (AD) patients with [11C]BF227 and 10 HC subjects and 10 probable AD patients with [18F]FACT. Data from nine regions of interest were analyzed by several approaches, namely non-linear least-squared fitting methods with arterial input functions (one-tissue compartment model(1TCM), two-tissue compartment model (2TCM)), Logan plot, and linearized methods with reference region (Reference Logan plot (RefLogan), MRTM0, MRTM2). We also evaluated SUV and SUVR for both tracers. The parameters estimated by several approaches were compared between two tracers for detectability of differences between HC and AD patients. Results: For [11C]BF227, there were no significant difference of VT (2TCM, 1TCM) and SUV in all regions (Student t-test; p < 0.05) and significant differences in the DVRs (Logan, RefLogan, and MRTM2) and SUVRs in six neocortical regions (p < 0.05) between the HC and AD groups. For [18F]FACT, significant differences in DVRs (RefLogan, MRTM0, and MRTM2) were observed in more than four neocortical regions between the HC and AD groups (p < 0.05), and the significant differences were found in SUVRs for two neocortical regions (inferior frontal coretex and lateral temporal coretex). Our results showed that both tracers can clearly distinguish between HC and AD groups although the pharmacokinetics and distribution patterns in brain for two tracers were substantially different. Conclusion: This study revealed that although the PET amyloid imaging agents [11C]BF227 and [18F]FACT have similar chemical and biological properties, they have different pharmacokinetics, and caution must be paid for usage of the tracers

  10. Mapping out Map Libraries

    Directory of Open Access Journals (Sweden)

    Ferjan Ormeling

    2008-09-01

    Full Text Available Discussing the requirements for map data quality, map users and their library/archives environment, the paper focuses on the metadata the user would need for a correct and efficient interpretation of the map data. For such a correct interpretation, knowledge of the rules and guidelines according to which the topographers/cartographers work (such as the kind of data categories to be collected, and the degree to which these rules and guidelines were indeed followed are essential. This is not only valid for the old maps stored in our libraries and archives, but perhaps even more so for the new digital files as the format in which we now have to access our geospatial data. As this would be too much to ask from map librarians/curators, some sort of web 2.0 environment is sought where comments about data quality, completeness and up-to-dateness from knowledgeable map users regarding the specific maps or map series studied can be collected and tagged to scanned versions of these maps on the web. In order not to be subject to the same disadvantages as Wikipedia, where the ‘communis opinio’ rather than scholarship, seems to be decisive, some checking by map curators of this tagged map use information would still be needed. Cooperation between map curators and the International Cartographic Association ( ICA map and spatial data use commission to this end is suggested.

  11. Consumer Insights

    Institute of Scientific and Technical Information of China (English)

    JANKOT

    2004-01-01

    Fang Jun, the head of consumer and market insights of Unilever Shanghai, has summarized his early life as a market in two sentences: rush about to study market changes;act all day to observe consumer behavior. And now?"Tell stories, conduct interviews and piece together different data; calculate numbers,build models and write reports."

  12. Diagnosis of regional cerebral blood flow abnormalities using SPECT: agreement between individualized statistical parametric maps and visual inspection by nuclear medicine physicians with different levels of expertise in nuclear neurology

    Energy Technology Data Exchange (ETDEWEB)

    Rocha, Euclides Timoteo da, E-mail: euclidestimoteo@uol.com.b [Fundacao Pio XII, Barretos, SP (Brazil). Hospital de Cancer. Dept. de Medicina Nuclear; Buchpiguel, Carlos Alberto [Hospital do Coracao, Sao Paulo, SP (Brazil). Dept. de Medicina Nuclear; Nitrini, Ricardo [Universidade de Sao Paulo (USP), SP (Brazil). Faculdade de Medicina. Dept. de Neurologia; Tazima, Sergio [Hospital Alemao Oswaldo Cruz (HAOC), Sao Paulo, SP (Brazil). Dept. de Medicina Nuclear; Peres, Stela Verzinhase [Fundacao Pio XII, Barretos, SP (Brazil). Hospital de Cancer; Busatto Filho, Geraldo [Universidade de Sao Paulo (USP), SP (Brazil). Faculdade de Medicina. Div. de Medicina Nuclear

    2009-07-01

    Introduction: visual analysis is widely used to interpret regional cerebral blood flow (rCBF) SPECT images in clinical practice despite its limitations. Automated methods are employed to investigate between-group rCBF differences in research studies but have rarely been explored in individual analyses. Objectives: to compare visual inspection by nuclear physicians with the automated statistical parametric mapping program using a SPECT dataset of patients with neurological disorders and normal control images. Methods: using statistical parametric mapping, 14 SPECT images from patients with various neurological disorders were compared individually with a databank of 32 normal images using a statistical threshold of p<0.05 (corrected for multiple comparisons at the level of individual voxels or clusters). Statistical parametric mapping results were compared with visual analyses by a nuclear physician highly experienced in neurology (A) as well as a nuclear physician with a general background of experience (B) who independently classified images as normal or altered, and determined the location of changes and the severity. Results: of the 32 images of the normal databank, 4 generated maps showing rCBF abnormalities (p<0.05, corrected). Among the 14 images from patients with neurological disorders, 13 showed rCBF alterations. Statistical parametric mapping and physician A completely agreed on 84.37% and 64.28% of cases from the normal databank and neurological disorders, respectively. The agreement between statistical parametric mapping and ratings of physician B were lower (71.18% and 35.71%, respectively). Conclusion: statistical parametric mapping replicated the findings described by the more experienced nuclear physician. This finding suggests that automated methods for individually analyzing rCBF SPECT images may be a valuable resource to complement visual inspection in clinical practice. (author)

  13. Compromised Cerebral Blood Flow(CBF) in Congestive Heart Failure (CHB): non-invasive quantification with {sup 99m}Tc-ECD radionuclide angiography

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Seung; Kim, Jae Joong; Lim, Ki Chun; Lee, Hee Kyung; Moon, Dae Hyuk [Ulsan University College of Medicine, Seoul (Korea, Republic of)

    2002-07-01

    Recent reports revealed that cerebral metabolism in CHF was abnormally deranged and proposed as a potential marker of disease severity. Since deranged cerebral metabolism in CHF may result from compromised cerebral perfusion, quantification of CHF may be useful for accurate risk stratification of CHF. Therefore, we investigated whether CHF in patients with CHF is compromised and correlated with clinical parameters. Fifteen patients (M/F:11/5, 45{+-}9yr) with CHF (LVEF<40%) and 7 healthy controls (M/F:5/2, 41{+-}8yr) were prospectively studied. All patients underwent radionuclide angiography including cerebral hemispheres and aortic arch using {sup 99m}Tc-ECD. Global CBF was measured non-invasively by the application of Patlak graphical plot analysis. All patients were also evaluated using a standardized protocol that included echocardiography and clinical evaluation. Global CBF (40.3{+-}5.2 ml/min/100g) of the patients with CHF were significantly lower than those (49.7{+-}2.4 ml/min/100g) of controls (p<0.01). Global CBF were correlated with NYHA functional class (r=-0.617, p=0.43), but not correlated with other clinical parameters such as age (r=-0.463, p=0.082), duration (r=0.237, p>0.1), systolic BP (r=-0.063, p>0.5), LVEF (r=-0.13, p>0.1), LV dimension(r=0.139, p>0.5), and PV pressure gradients (r=0.072, p>0.5). Cerebral perfusion of the patients with CHF was compromised and not correlated with cardiopulmonary hemodynamic parameters.

  14. TIPS bilateral noise reduction in 4D CT perfusion scans produces high-quality cerebral blood flow maps

    Energy Technology Data Exchange (ETDEWEB)

    Mendrik, Adrienne M; Van Ginneken, Bram; Viergever, Max A [Image Sciences Institute, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht (Netherlands); Vonken, Evert-jan; De Jong, Hugo W; Riordan, Alan; Van Seeters, Tom; Smit, Ewoud J; Prokop, Mathias, E-mail: a.m.mendrik@gmail.com [Radiology Department, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht (Netherlands)

    2011-07-07

    Cerebral computed tomography perfusion (CTP) scans are acquired to detect areas of abnormal perfusion in patients with cerebrovascular diseases. These 4D CTP scans consist of multiple sequential 3D CT scans over time. Therefore, to reduce radiation exposure to the patient, the amount of x-ray radiation that can be used per sequential scan is limited, which results in a high level of noise. To detect areas of abnormal perfusion, perfusion parameters are derived from the CTP data, such as the cerebral blood flow (CBF). Algorithms to determine perfusion parameters, especially singular value decomposition, are very sensitive to noise. Therefore, noise reduction is an important preprocessing step for CTP analysis. In this paper, we propose a time-intensity profile similarity (TIPS) bilateral filter to reduce noise in 4D CTP scans, while preserving the time-intensity profiles (fourth dimension) that are essential for determining the perfusion parameters. The proposed TIPS bilateral filter is compared to standard Gaussian filtering, and 4D and 3D (applied separately to each sequential scan) bilateral filtering on both phantom and patient data. Results on the phantom data show that the TIPS bilateral filter is best able to approach the ground truth (noise-free phantom), compared to the other filtering methods (lowest root mean square error). An observer study is performed using CBF maps derived from fifteen CTP scans of acute stroke patients filtered with standard Gaussian, 3D, 4D and TIPS bilateral filtering. These CBF maps were blindly presented to two observers that indicated which map they preferred for (1) gray/white matter differentiation, (2) detectability of infarcted area and (3) overall image quality. Based on these results, the TIPS bilateral filter ranked best and its CBF maps were scored to have the best overall image quality in 100% of the cases by both observers. Furthermore, quantitative CBF and cerebral blood volume values in both the phantom and the

  15. TIPS bilateral noise reduction in 4D CT perfusion scans produces high-quality cerebral blood flow maps

    International Nuclear Information System (INIS)

    Cerebral computed tomography perfusion (CTP) scans are acquired to detect areas of abnormal perfusion in patients with cerebrovascular diseases. These 4D CTP scans consist of multiple sequential 3D CT scans over time. Therefore, to reduce radiation exposure to the patient, the amount of x-ray radiation that can be used per sequential scan is limited, which results in a high level of noise. To detect areas of abnormal perfusion, perfusion parameters are derived from the CTP data, such as the cerebral blood flow (CBF). Algorithms to determine perfusion parameters, especially singular value decomposition, are very sensitive to noise. Therefore, noise reduction is an important preprocessing step for CTP analysis. In this paper, we propose a time-intensity profile similarity (TIPS) bilateral filter to reduce noise in 4D CTP scans, while preserving the time-intensity profiles (fourth dimension) that are essential for determining the perfusion parameters. The proposed TIPS bilateral filter is compared to standard Gaussian filtering, and 4D and 3D (applied separately to each sequential scan) bilateral filtering on both phantom and patient data. Results on the phantom data show that the TIPS bilateral filter is best able to approach the ground truth (noise-free phantom), compared to the other filtering methods (lowest root mean square error). An observer study is performed using CBF maps derived from fifteen CTP scans of acute stroke patients filtered with standard Gaussian, 3D, 4D and TIPS bilateral filtering. These CBF maps were blindly presented to two observers that indicated which map they preferred for (1) gray/white matter differentiation, (2) detectability of infarcted area and (3) overall image quality. Based on these results, the TIPS bilateral filter ranked best and its CBF maps were scored to have the best overall image quality in 100% of the cases by both observers. Furthermore, quantitative CBF and cerebral blood volume values in both the phantom and the

  16. TIPS bilateral noise reduction in 4D CT perfusion scans produces high-quality cerebral blood flow maps

    Science.gov (United States)

    Mendrik, Adriënne M.; Vonken, Evert-jan; van Ginneken, Bram; de Jong, Hugo W.; Riordan, Alan; van Seeters, Tom; Smit, Ewoud J.; Viergever, Max A.; Prokop, Mathias

    2011-07-01

    Cerebral computed tomography perfusion (CTP) scans are acquired to detect areas of abnormal perfusion in patients with cerebrovascular diseases. These 4D CTP scans consist of multiple sequential 3D CT scans over time. Therefore, to reduce radiation exposure to the patient, the amount of x-ray radiation that can be used per sequential scan is limited, which results in a high level of noise. To detect areas of abnormal perfusion, perfusion parameters are derived from the CTP data, such as the cerebral blood flow (CBF). Algorithms to determine perfusion parameters, especially singular value decomposition, are very sensitive to noise. Therefore, noise reduction is an important preprocessing step for CTP analysis. In this paper, we propose a time-intensity profile similarity (TIPS) bilateral filter to reduce noise in 4D CTP scans, while preserving the time-intensity profiles (fourth dimension) that are essential for determining the perfusion parameters. The proposed TIPS bilateral filter is compared to standard Gaussian filtering, and 4D and 3D (applied separately to each sequential scan) bilateral filtering on both phantom and patient data. Results on the phantom data show that the TIPS bilateral filter is best able to approach the ground truth (noise-free phantom), compared to the other filtering methods (lowest root mean square error). An observer study is performed using CBF maps derived from fifteen CTP scans of acute stroke patients filtered with standard Gaussian, 3D, 4D and TIPS bilateral filtering. These CBF maps were blindly presented to two observers that indicated which map they preferred for (1) gray/white matter differentiation, (2) detectability of infarcted area and (3) overall image quality. Based on these results, the TIPS bilateral filter ranked best and its CBF maps were scored to have the best overall image quality in 100% of the cases by both observers. Furthermore, quantitative CBF and cerebral blood volume values in both the phantom and the

  17. 结缕草CBF基因的同源克隆及其转基因拟南芥的抗寒性验证%Cloning of Zoysiagrass CBF Gene and Validation of Cold Tolerance in Trans-genic Arabidopsis

    Institute of Scientific and Technical Information of China (English)

    冯勋伟; 才宏伟

    2014-01-01

    结缕草是优良的暖季型草坪草之一,主要用于亚热带和热带地区的草坪种植。抗冷性是结缕草栽培范围的限制因子。本研究以日本最北部原产的结缕草品系为材料,根据其他植物的已知的抗寒基因 CBF 序列,通过同源克隆的方法获得结缕草中相对应的同源基因ZjCBF;根据和其他已报告的CBF序列的比对结果,确定ZjCBF基因属于CBF转录因子家族基因中CBF1型基因。利用半定量PCR和实时定量PCR分析该基因在寒冷条件下的表达情况,发现ZjCBF基因受冷胁迫的诱导,在4℃处理6 h时表达量最高。在此基础上,本研究构建了该基因的过表达载体,并将其转化到拟南芥中,通过低温冷处理实验发现,不论是否经过冷驯化,转 ZjCBF 基因植株由于 ZjCBF 的过量表达均比野生型植株抗寒性强。%Zoysiagrass is recognized as an excellent warm-season turfgrass and mainly used in subtropical and tropical regions. Cold stress is a major constraint factor for the cultivation of zoysiagrass. In this study, according to the sequences of cold tolerance gene CBF had been reported in other plant species, we cloned the corresponding homologous of the ZjCBF gene by homology cloning method in Zoysia japonica using a material originated from the most northern area of Japan. Based on the alignment re-sults compared with other reported CBF genes, we found the ZjCBF gene belongs to the CBF1 familiy. By semi-quantitative PCR and real-time quantitative PCR, we analyzed the expression level of the ZjCBF gene in the cold condition and found that ZjCBF was induced by cold stress, and the ZjCBF expression reached peak at six hours post 4°C treatment. In addition, we also con-structed ZjCBF over expression vector and generated transgenic Arabidopsis plants, with better cold tolerance than the wild-type, whether through cold acclimation or not.

  18. The Arabidopsis mediator complex subunits MED16, MED14, and MED2 regulate mediator and RNA polymerase II recruitment to CBF-responsive cold-regulated genes.

    Science.gov (United States)

    Hemsley, Piers A; Hurst, Charlotte H; Kaliyadasa, Ewon; Lamb, Rebecca; Knight, Marc R; De Cothi, Elizabeth A; Steele, John F; Knight, Heather

    2014-01-01

    The Mediator16 (MED16; formerly termed SENSITIVE TO FREEZING6 [SFR6]) subunit of the plant Mediator transcriptional coactivator complex regulates cold-responsive gene expression in Arabidopsis thaliana, acting downstream of the C-repeat binding factor (CBF) transcription factors to recruit the core Mediator complex to cold-regulated genes. Here, we use loss-of-function mutants to show that RNA polymerase II recruitment to CBF-responsive cold-regulated genes requires MED16, MED2, and MED14 subunits. Transcription of genes known to be regulated via CBFs binding to the C-repeat motif/drought-responsive element promoter motif requires all three Mediator subunits, as does cold acclimation-induced freezing tolerance. In addition, these three subunits are required for low temperature-induced expression of some other, but not all, cold-responsive genes, including genes that are not known targets of CBFs. Genes inducible by darkness also required MED16 but required a different combination of Mediator subunits for their expression than the genes induced by cold. Together, our data illustrate that plants control transcription of specific genes through the action of subsets of Mediator subunits; the specific combination defined by the nature of the stimulus but also by the identity of the gene induced. PMID:24415770

  19. Genome mapping of the horse

    OpenAIRE

    Lindgren, Gabriella

    2001-01-01

    Our ability to map and sequence whole genomes is one of the most important developments in biological science. It will provide us with an unprecedented insight into the genetic background of phenotypic traits, such as disease resistance, reproduction and growth and also makes it feasible to study the processes of genome evolution. The main focus of this thesis has been to develop a linkage map of the horse (Equus caballus) genome. A secondary aim was to expand the number of physically mapped ...

  20. Cerebral blood flow and related factors in hyperthyroidism patients by SPECT imaging and statistical parametric mapping analysis

    International Nuclear Information System (INIS)

    Objective: To investigate the cerebral blood flow (CBF) perfusion patterns and related factors in hyperthyroidism patients. Methods: Twenty-five patients with hyperthyroidism and twenty-two healthy controls matched for age, sex, education were enrolled. 99Tcm-ethylene cysteinate dimer (ECD) SPECT CBF perfusion imaging was performed at rest. Statistical parametric mapping 5.0 software (SPM5) was used and a statistical threshold of P3, FT4), thyroid autoimmune antibodies: sensitive thyroid stimulating hormone (sTSH), thyroid peroxidase antibody (TPOAb) and TSH receptor antibody (TRAb) by Pearson analysis, with disease duration by Spearman analysis. Results: rCBF was decreased significantly in limbic system and frontal lobe, including parahippocampal gyrus, uncus (posterior entorhinal cortex, posterior parolfactory cortex, parahippocampal cortex, anterior cingulate, right inferior temporal gyrus), left hypothalamus and caudate nucleus (P3 (r=-0.468, -0.417, both P4 (r=-0.4M, -0.418, -0.415, -0.459, all P4 (r=0.419, 0.412, both P<0.05). rCBF in left insula was negatively correlated with concentration of sTSH, and right auditory associated cortex was positively correlated with concentration of sTSH (r=-0.504, 0.429, both P<0.05). rCBF in left middle temporal gyrus, left angular gyrus was positively correlated with concentration of TRAb while that in right thalamus, right hypothalamus, left anterior nucleus,left ventralis nucleus was negatively correlated with concentration of TRAb (r=0.750, 0.862, -0.691, -0.835, -0.713, -0.759, all P<0.05). rCBF in right anterior cingulate, right cuneus, right rectus gyrus, right superior marginal gyrus was positively correlated with concentration of TPOAb (r=0.696, 0.581, 0.779, 0.683, all P<0.05). rCBF in postcentral gyrus, temporal gyrus, left superior marginal gyrus and auditory associated cortex was positively correlated with disease duration (r=0.502, 0.457, 0.524, 0.440, all P<0.05). Conclusion: Hypoperfusions in limbic system

  1. Planetary maps

    Science.gov (United States)

    ,

    1992-01-01

    An important goal of the USGS planetary mapping program is to systematically map the geology of the Moon, Mars, Venus, and Mercury, and the satellites of the outer planets. These geologic maps are published in the USGS Miscellaneous Investigations (I) Series. Planetary maps on sale at the USGS include shaded-relief maps, topographic maps, geologic maps, and controlled photomosaics. Controlled photomosaics are assembled from two or more photographs or images using a network of points of known latitude and longitude. The images used for most of these planetary maps are electronic images, obtained from orbiting television cameras, various optical-mechanical systems. Photographic film was only used to map Earth's Moon.

  2. Required time delay from (99m)Tc-HMPAO injection to SPECT data acquisition: healthy subjects and patients with rCBF pattern

    DEFF Research Database (Denmark)

    Thomsen, G.; de, Nijs R.; Hogh-Rasmussen, E.;

    2008-01-01

    patients. This study investigates in patients with perfusion deficits and in healthy subjects if the quality of the SPECT image is affected by lowering the time delay between (99m)Tc-HMPAO injection and data acquisition to 30 or 60 min. METHODS: Thirty-seven healthy subjects (17 females; mean age 65; range...... Procedure Guidelines for Brain Perfusion SPET using (99m)Tc-labeled Radiopharmaceuticals recommend a time delay of 90 min between injection of (99m)Tc-HMPAO and data acquisition. This time delay is difficult to comply within the daily routine and present a problem, particularly with the elderly or demented...... 42-84 years) with normal cerebral blood flow distribution and 31 patients (17 females; mean age 67; range 38-84) with reduced rCBF distribution were included. Images were obtained with a three-headed Philips IRIX SPECT scanner with high-resolution collimators. The healthy subjects were scanned 30, 60...

  3. A limitation of the split-dose method for evaluating rCBF changes using {sup 99m}Tc-ECD and SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Odano, Ikuo; Takahashi, Makoto; Noguchi, Eikichi; Ohtaki, Hiro; Shibaki, Mitsurou; Kasahara, Tosifumi; Hatano, Masayoshi [Niigata Univ. (Japan). School of Medicine; Ohkubo, Masaki

    1997-05-01

    The purpose of the study is to validate the split-dose method corrected with dose ratio of {sup 99m}Tc-ECD for brain perfusion scan. A dose of 600 MBq of {sup 99m}Tc-ECD was divided into two with various dose ratios from 1 : 1 to 1 : 4, and injected to eleven patients with various cerebral diseases. A lesser dose of {sup 99m}Tc-ECD was injected under a control state for the first SPECT scan, and 15 min SPECT scan was performed 10 min after injection with a triple-head high resolution gamma camera. After the scan, the other dose of {sup 99m}Tc-ECD was injected under the same control state and the second SPECT scan was performed as same as above. A ratio of the activity of the first scan to the net activity of the second scan corrected by dose ratio, defined as K, was measured in brain regions of each subject. Expected value of K was 1, but the value was distributed with large variations in each subject. The mean % error of the K value was 10.4{+-}4.9%. Hence it is considered that activity changes by more than 20% from the control values should be required to detect a significant rCBF change in an activation SPECT study. Then, we proposed a new method in which the activity of both two SPECT scans was normalized by cerebellar or occipital activity and compared. The ratio obtained by the proposed method came closer to 1 with less variations and with less mean % error in comparison with those of K value obtained by the dose-correction method. Although the proposed method has a limitation in the use of an activation study loaded with Diamox, it may be useful to evaluate an alteration of rCBF in the study such as postural testing or finger-moving test. (author)

  4. Early Rehabilitation of Acute Stroke Patients with Hemiplegia and Effects of regional Cerebral Blood Flow (rCBF) of the Patients with Cerebral Infarction by Early Rehabiiitation

    Institute of Scientific and Technical Information of China (English)

    Luo ZuMing; Xiong Hai

    2000-01-01

    Objectives: To investigate whether early rchabilitation could improve obviously clinical prognosis of acute stroke patients. The mechanism of early rehabilitation that could improve brain function was preliminarily studied. Methods: 240 patients with acute hemiplegia were randomly divided into control group (120 cases) and rehabilitation group (120 cases). The control group received general treatment and the latter received early rehabilitation (Bobath methods) besides general treatment. At pre-rehabilitation and the end of 1,2,3,4,5,6 month at post-rehabilitation, the neurological deficit was assessed with modified Edinbcrg-Scandinavian stroke scale (MESSS); the motor function of the hemiplegic limbs were assessed with modified Fugl-meyer motor scale (FM);the ADL were assessed with modified Barthel Index (MBI), and the general secondary complications of both groups were also evaluated. Moreover, rCBF of 72 cases of acute cerebral infarction with hemiplegia (34 in control group, 38 in rehabilitation group) was earned out by SPECT imaging at pre-rehabilitation and at the end of I month at post - rehabilitation.Results and Discussion: Compared with those of control group, at the end of 1,2,3,4,5,6 month at post - rehabilitation, the scores of MESSS were more obviously decreased (p<0.05 and p<0.01); the scores of MBI and FM were more significantly increased (p<0.05 and p<0.01); and morbidity of secondary complications was more significantly decreased (p<0.05 and p<0.01). Compared with those of pre-rehabilitation in rehabilitation group, both the decrease of MESS scores and the increase of FM, MBI scores were more obvious (p<0.01) at the end of 1,2,3 month of post-rehabilitation; however, compared with that of the end of 3 month at post-rehabilitation, at the end of 4,5,6 month of post-rehabilitation in rehabilitation group. Both the decrease of MESSS scores and the increase of FM scores hadn′t statistical significance (p>0.05). but scores of MBt were

  5. Regional cerebral blood flow in children with autism spectrum disorders: a quantitative 99mTc-ECD brain SPECT study with statistical parametric mapping evaluation

    Institute of Scientific and Technical Information of China (English)

    YANG Wen-han; JING Jin; XIU Li-juan; CHENG Mu-hua; WANG Xin; BAO Peng; WANG Qing-xiong

    2011-01-01

    Background Autism spectrum disorders (ASD), which include autism, asperger syndrome (AS) and pervasive developmental disorder-not otherwise specified (PDD-NOS), are devastating neurodevelopmental disorders of childhood resulting in deficits in social interaction, repetitive patterns of behaviors, and restricted interests and activities. Single photon emission computed tomography (SPECT) is a common technique used to measure regional cerebral blood flow (rCBF). Several studies have measured rCBF in children with ASD using SPECT, however, findings are discordant. In addition, the majority of subjects used in these studies were autistic. In this study, we aimed to investigate changes in rCBF in children with ASD using SPECT.Methods A Technetium-99m-ethyl cysteinate dimmer (99mTc-ECD) brain SPECT study was performed on an ASD group consisting of 23 children (3 girls and 20 boys; mean age (7.2±3.0) years) who were diagnosed according to Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-Ⅳ) criteria and an age-matched control group with 8children (1 girl and 7 boys, mean age (5.5±2.4) years). Image data were evaluated with Statistical Parametric Mapping,5th version (SPM5). A Student's t test for unpaired data was used to compare rCBF and asymmetry in the autism and corresponding control group. The covariance analysis, taking age as covariance, was performed between the ASD and control group.Results There was a significant reduction in rCBF in the bilateral frontal lobe (frontal poles, arcula frontal gyrus) and the bilateral basal ganglia in the autism group, and a reduction in the bilateral frontal, temporal, parietal, legumina nucleus and cerebellum in the AS group compared to the control. In addition, asymmetry of hemispheric hypoperfusion in the ASD group was observed. Inner-group comparison analysis revealed that rCBF decreased significantly in the bilateral frontal lobe (42.7%), basal nucleus (24.9%) and temporal lobe (22.8%) in the autism

  6. Logical types and ostensive insight.

    Science.gov (United States)

    Ahumada, J L

    1991-01-01

    Discrimination of analogic and digital modes in communication allows clearer distinction of transference (mutative) and extra-transference interpretation. Relying on explicit formulation, Strachey introduces 'implicit' mutative interpretation, which is explicitly extra-transferential but transferential as to process. Each interpretive verbalization has an analogic impact pertaining to the analogic unconscious level of archaic objects, and its emitter--the analyst--is its propositional subject. Interpretation can afford to be as explicit as possible inasmuch as it retains the metalevel in which the analyst can remain as third-party to what he formulates, but it must be gradual in making explicit the archaic object he actualizes. It is by 'withholding'--as Strachey says--the validation of the archaic relational analogic 'psychic reality' that is the referent of interpretive 'mapping', and not be verbal 'mapping' in itself, that the 'judgement of reality' underlying ostensive insight comes into play. PMID:1797721

  7. Nucleotide Polymorphism in the Drought Induced Transcription Factor CBF4 Region of Arabidopsis thaliana and Its Molecular Evolution Analyses%拟南芥抗旱转录因子CBF4基因区域的核苷酸多样性及其分子进化分析

    Institute of Scientific and Technical Information of China (English)

    郝岗平; 吴忠义; 曹鸣庆; Georges Pelletier; Dominique Brunel; 黄丛林; 杨清

    2004-01-01

    以生长于不同气候条件下的17个拟南芥核心生态型为材料,分析了它们的抗旱转录因子CBF4 基因区域的序列多态性.结果表明:拟南芥CBF4基因区域具有高密度的单核苷酸多态性(SNP)和插入缺失(Indel),多态性频率为每35.8 bp一个 SNP,每143 bp一个Indel,基因非编码区的多态性是编码区的4倍;在编码区,SNP的频率为每96.4 bp一个SNP,其中发现25 av、203 av和244 av 3个生态型CBF4基因区域1 034位 (以GenBank登录号AB015478序列第19 696位的核苷酸为1)碱基变化:G(←→)T,引起第205位氨基酸变化:gly(←→)val.核苷酸多样性统计分析显示,该基因内部大范围内存在连锁不平衡(linkage disequilibrium,LD),5′端非编码区有一个重组.与拟南芥等的研究结果类似,选择压力对不同的区域作用不同.3′端非编码区核苷酸多样性程度最高,是平衡性选择的结果,编码区核苷酸变化符合中性突变假说,而5′端非编码区是自然选择作用的靶位点.

  8. Map Projection

    CERN Document Server

    Ghaderpour, Ebrahim

    2014-01-01

    In this paper, we introduce some known map projections from a model of the Earth to a flat sheet of paper or map and derive the plotting equations for these projections. The first fundamental form and the Gaussian fundamental quantities are defined and applied to obtain the plotting equations and distortions in length, shape and size for some of these map projections.

  9. Arterial Input Function Placement for Accurate CT Perfusion Map Construction in Acute Stroke

    Science.gov (United States)

    Ferreira, Rafael M.; Lev, Michael H.; Goldmakher, Gregory V.; Kamalian, Shahmir; Schaefer, Pamela W.; Furie, Karen L.; Gonzalez, R. Gilberto; Sanelli, Pina C.

    2013-01-01

    OBJECTIVE The objective of our study was to evaluate the effect of varying arterial input function (AIF) placement on the qualitative and quantitative CT perfusion parameters. MATERIALS AND METHODS Retrospective analysis of CT perfusion data was performed on 14 acute stroke patients with a proximal middle cerebral artery (MCA) clot. Cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) maps were constructed using a systematic method by varying only the AIF placement in four positions relative to the MCA clot including proximal and distal to the clot in the ipsilateral and contralateral hemispheres. Two postprocessing software programs were used to evaluate the effect of AIF placement on perfusion parameters using a delay-insensitive deconvolution method compared with a standard deconvolution method. RESULTS One hundred sixty-eight CT perfusion maps were constructed for each software package. Both software programs generated a mean CBF at the infarct core of < 12 mL/100 g/min and a mean CBV of < 2 mL/100 g for AIF placement proximal to the clot in the ipsilateral hemisphere and proximal and distal to the clot in the contralateral hemisphere. For AIF placement distal to the clot in the ipsilateral hemisphere, the mean CBF significantly increased to 17.3 mL/100 g/min with delay-insensitive software and to 19.4 mL/100 g/min with standard software (p < 0.05). The mean MTT was significantly decreased for this AIF position. Furthermore, this AIF position yielded qualitatively different parametric maps, being most pronounced with MTT and CBF. Overall, CBV was least affected by AIF location. CONCLUSION For postprocessing of accurate quantitative CT perfusion maps, laterality of the AIF location is less important than avoiding AIF placement distal to the clot as detected on CT angiography. This pitfall is less severe with deconvolution-based software programs using a delay-insensitive technique than with those using a standard deconvolution

  10. Kohler's Insight Revisited.

    Science.gov (United States)

    Windholtz, George

    1985-01-01

    Psychology textbooks frequently present Wolfgang Kohler's two-stick experiment with chimpanzees as having demonstrated insight in learning. Studies that replicated Kohler's work support his findings but not his interpretation in terms of insightful solution. The uncritical inclusion of Kohler's insight interpretation in texts is not warranted in…

  11. Proofs that Develop Insight

    Science.gov (United States)

    Weber, Keith

    2010-01-01

    Many mathematics educators have noted that mathematicians do not only read proofs to gain conviction but also to obtain insight. The goal of this article is to discuss what this insight is from mathematicians' perspective. Based on interviews with nine research-active mathematicians, two sources of insight are discussed. The first is reading a…

  12. Harmonic Maps and Biharmonic Maps

    OpenAIRE

    Hajime Urakawa

    2015-01-01

    This is a survey on harmonic maps and biharmonic maps into (1) Riemannian manifolds of non-positive curvature, (2) compact Lie groups or (3) compact symmetric spaces, based mainly on my recent works on these topics.

  13. Quantitative β mapping for calibrated fMRI.

    Science.gov (United States)

    Shu, Christina Y; Sanganahalli, Basavaraju G; Coman, Daniel; Herman, Peter; Rothman, Douglas L; Hyder, Fahmeed

    2016-02-01

    The metabolic and hemodynamic dependencies of the blood oxygenation level-dependent (BOLD) signal form the basis for calibrated fMRI, where the focus is on oxidative energy demanded by neural activity. An important part of calibrated fMRI is the power-law relationship between the BOLD signal and the deoxyhemoglobin concentration, which in turn is related to the ratio between oxidative demand (CMRO2) and blood flow (CBF). The power-law dependence between BOLD signal and deoxyhemoglobin concentration is signified by a scaling exponent β. Until recently most studies assumed a β value of 1.5, which is based on numerical simulations of the extravascular BOLD component. Since the basal value of CMRO2 and CBF can vary from subject-to-subject and/or region-to-region, a method to independently measure β in vivo should improve the accuracy of calibrated fMRI results. We describe a new method for β mapping through characterizing R2' - the most sensitive relaxation component of BOLD signal (i.e., the reversible magnetic susceptibility component that is predominantly of extravascular origin at high magnetic field) - as a function of intravascular magnetic susceptibility induced by an FDA-approved superparamagnetic contrast agent. In α-chloralose anesthetized rat brain, at 9.4 T, we measured β values of ~0.8 uniformly across large neocortical swathes, with lower magnitude and more heterogeneity in subcortical areas. Comparison of β maps in rats anesthetized with medetomidine and α-chloralose revealed that β is independent of neural activity levels at these resting states. We anticipate that this method for β mapping can help facilitate calibrated fMRI for clinical studies. PMID:26619788

  14. 盐地碱蓬2个DREB1/CBF基因的克隆与表达调控分析%Cloning and Expression Analysis of TwoDREB1/CBF Genes inSuaeda salsaL

    Institute of Scientific and Technical Information of China (English)

    孙晓波; 苏家乐; 贾新平; 梁丽建; 肖政; 邓衍明

    2016-01-01

    【目的】从盐地碱蓬(Suaeda salsaL.)中克隆2个DREB1/CBF,分析其序列特征、编码蛋白的亚细胞定位和转录激活活性,以及在非生物胁迫下的表达模式,为进一步研究盐地碱蓬的抗逆机制提供依据。【方法】利用同源克隆法获得盐地碱蓬2个DREB1/CBF片段,采用RACE技术克隆获得cDNA全长序列,分别命名为SsCBF1和SsCBF2。运用生物信息学软件对2个SsCBF及其编码蛋白进行分析,并将它们分别与GFP融合构建植物表达载体,通过基因枪转化法导入洋葱表皮细胞进行瞬时表达,观察它们编码蛋白的亚细胞定位。利用酵母单杂交系统研究2个SsCBF与DRE/CRT顺式作用元件的结合特异性和转录激活活性。采用Real time-PCR研究2个SsCBF在低温、NaCl、PEG 以及 ABA 处理下的表达模式。【结果】 SsCBF1编码一个225个氨基酸的蛋白,预测分子量为25.4 kD,理论等电点为4.84。SsCBF2编码一个由260个氨基酸组成的蛋白,预测分子量为28.6 kD,理论等电点为5.05。SsCBF1和SsCBF2均含有1个典型的AP2/ERF保守结构域,在核苷酸和氨基酸水平上分别具有53.5%和45.4%的同源性,而2个基因的 AP2/ERF 结构域在核苷酸和氨基酸水平上分别具有76.2%和87.3%的相似性。SsCBF1、SsCBF2归属于DREB亚组的A-1组,定位于细胞核内,均能与DRE/CRT顺式作用元件特异性结合,并激活下游报告基因的表达。低温、干旱、高盐和ABA能够诱导SsCBF1表达,而SsCBF2在低温处理下表达量上调,但对干旱、高盐和ABA处理不响应。【结论】SsCBF1和SsCBF2是盐地碱蓬的2个胁迫应答转录因子。在盐地碱蓬中,SsCBF1通过依赖ABA途径参与对高盐、干旱和低温等非生物胁迫的应激调控,而SsCBF2则通过不依赖于ABA途径对低温胁迫产生响应。%Objective] To provide basic information for understanding the resistant mechanism under abiotic stresses, two

  15. Introduction to "Mapping Vietnameseness"

    Directory of Open Access Journals (Sweden)

    Hue-Tam Ho Tai

    2016-09-01

    Full Text Available Vietnam and China are currently engaged in a map war, with each country using ancient maps to buttress its claims to territorial sovereignty over some uninhabited islands in the South China Sea (in Chinese terminology, also known as the Eastern Sea (in Vietnamese. But what do maps in fact represent? What is meant by “territory”? How are territorial limits conceived? These questions were raised in a May 2015 workshop inspired by Thongchai Winichakul’s Siam Mapped: A History of the Geo-Body of a Nation (1994, a groundbreaking book that traces the transformation of Thai geographical consciousness as a result of Siam’s encounter with Western powers in the nineteenth century. While many of Thongchai’s insights apply to the Vietnamese case, as the first of the three articles included in this special issue of Cross-Currents shows, some of the 2015 workshop participants’ conclusions departed from his, especially regarding the formation of a Vietnamese geographical consciousness before the colonial period.[i] This is true of the other two papers, which focus specifically on the construction of borders and the associated production of maps in the nineteenth century before French colonial conquest... Notes 1 Thanks are due to the Max Planck Institute for the Study of Religious and Ethnic Change in Gottingen, Germany, for its gracious hosting and generous funding of the conference, together with the Asia Center of Harvard University.

  16. Single photon emission computed tomography and statistical parametric mapping analysis in cirrhotic patients with and without minimal hepatic encephalopathy

    International Nuclear Information System (INIS)

    The early diagnosis and treatment of cognitive impairment in cirrhotic patients is needed to improve the patients' daily living. In this study, alterations of regional cerebral blood flow (rCBF) were evaluated in cirrhotic patients using statistical parametric mapping (SPM). The relationships between rCBF and neuropsychological test, severity of disease and biochemical data were also assessed. 99mTc-ethyl cysteinate dimer single photon emission computed tomography was performed in 20 patients with non-alcoholic liver cirrhosis without overt hepatic encephalopathy (HE) and in 20 age-matched healthy subjects. Neuropsychological tests were performed in 16 patients; of these 7 had minimal HE. Regional CBF images were also analyzed in these groups using SPM. On SPM analysis, cirrhotic patients showed regions of significant hypoperfusion in the superior and middle frontal gyri, and inferior parietal lobules compared with the control group. These areas included parts of the premotor and parietal associated areas of the cortex. Among the cirrhotic patients, those with minimal HE had regions of significant hypoperfusion in the cingulate gyri bilaterally as compared with those without minimal HE. Abnormal function in the above regions may account for the relatively selective neuropsychological deficits in the cognitive status of patients with cirrhosis. These findings may be important in the identification and management of cirrhotic patients with minimal HE. (author)

  17. CBF tomograms with (/sup 99m/Tc-HM-PAO in patients with dementia (Alzheimer type and HIV) and Parkinson's disease--initial results

    Energy Technology Data Exchange (ETDEWEB)

    Costa, D.C.; Ell, P.J.; Burns, A.; Philpot, M.; Levy, R.

    1988-12-01

    We present preliminary data on the utility of functional brain imaging with (99mTc)-d,l-HM-PAO and single photon emission computed tomography (SPECT) in the study of patients with dementia of the Alzheimer type (DAT), HIV-related dementia syndrome, and the on-off syndrome of Parkinson's disease. In comparison with a group of age-matched controls, the DAT patients revealed distinctive bilateral temporal and posterior parietal deficits, which correlate with detailed psychometric evaluation. Patients with amnesia as the main symptom (group A) showed bilateral mesial temporal lobe perfusion deficits (p less than 0.02). More severely affected patients (group B) with significant apraxia, aphasia, or agnosia exhibited patterns compatible with bilateral reduced perfusion in the posterior parietal cortex, as well as reduced perfusion to both temporal lobes, different from the patients of the control group (p less than 0.05). SPECT studies of HIV patients with no evidence of intracraneal space occupying pathology showed marked perfusion deficits. Patients with Parkinson's disease and the on-off syndrome studied during an on phase (under levodopa therapy) and on another occasion after withdrawal of levodopa (off) demonstrated a significant change in the uptake of (99mTc)-d,l-HM-PAO in the caudate nucleus (lower on off) and thalamus (higher on off). These findings justify the present interest in the functional evaluation of the brain of patients with dementia. (99mTc)-d,l-HM-PAO and regional cerebral blood flow (rCBF)/SPECT appear useful and highlight individual disorders of flow in a variety of neuropsychiatric conditions.

  18. CBF tomograms with [/sup 99m/Tc-HM-PAO in patients with dementia (Alzheimer type and HIV) and Parkinson's disease--initial results

    International Nuclear Information System (INIS)

    We present preliminary data on the utility of functional brain imaging with [99mTc]-d,l-HM-PAO and single photon emission computed tomography (SPECT) in the study of patients with dementia of the Alzheimer type (DAT), HIV-related dementia syndrome, and the on-off syndrome of Parkinson's disease. In comparison with a group of age-matched controls, the DAT patients revealed distinctive bilateral temporal and posterior parietal deficits, which correlate with detailed psychometric evaluation. Patients with amnesia as the main symptom (group A) showed bilateral mesial temporal lobe perfusion deficits (p less than 0.02). More severely affected patients (group B) with significant apraxia, aphasia, or agnosia exhibited patterns compatible with bilateral reduced perfusion in the posterior parietal cortex, as well as reduced perfusion to both temporal lobes, different from the patients of the control group (p less than 0.05). SPECT studies of HIV patients with no evidence of intracraneal space occupying pathology showed marked perfusion deficits. Patients with Parkinson's disease and the on-off syndrome studied during an on phase (under levodopa therapy) and on another occasion after withdrawal of levodopa (off) demonstrated a significant change in the uptake of [99mTc]-d,l-HM-PAO in the caudate nucleus (lower on off) and thalamus (higher on off). These findings justify the present interest in the functional evaluation of the brain of patients with dementia. [99mTc]-d,l-HM-PAO and regional cerebral blood flow (rCBF)/SPECT appear useful and highlight individual disorders of flow in a variety of neuropsychiatric conditions

  19. Graphene Conductance Uniformity Mapping

    DEFF Research Database (Denmark)

    Buron, Jonas Christian Due; Petersen, Dirch Hjorth; Bøggild, Peter;

    2012-01-01

    We demonstrate a combination of micro four-point probe (M4PP) and non-contact terahertz time-domain spectroscopy (THz-TDS) measurements for centimeter scale quantitative mapping of the sheet conductance of large area chemical vapor deposited graphene films. Dual configuration M4PP measurements......, demonstrated on graphene for the first time, provide valuable statistical insight into the influence of microscale defects on the conductance, while THz-TDS has potential as a fast, non-contact metrology method for mapping of the spatially averaged nanoscopic conductance on wafer-scale graphene with scan times...... of less than a minute for a 4-in. wafer. The combination of M4PP and THz-TDS conductance measurements, supported by micro Raman spectroscopy and optical imaging, reveals that the film is electrically continuous on the nanoscopic scale with microscopic defects likely originating from the transfer process...

  20. CAD system for automatic analysis of CT perfusion maps

    Science.gov (United States)

    Hachaj, T.; Ogiela, M. R.

    2011-03-01

    In this article, authors present novel algorithms developed for the computer-assisted diagnosis (CAD) system for analysis of dynamic brain perfusion, computer tomography (CT) maps, cerebral blood flow (CBF), and cerebral blood volume (CBV). Those methods perform both quantitative analysis [detection and measurement and description with brain anatomy atlas (AA) of potential asymmetries/lesions] and qualitative analysis (semantic interpretation of visualized symptoms). The semantic interpretation (decision about type of lesion: ischemic/hemorrhagic, is the brain tissue at risk of infraction or not) of visualized symptoms is done by, so-called, cognitive inference processes allowing for reasoning on character of pathological regions based on specialist image knowledge. The whole system is implemented in.NET platform (C# programming language) and can be used on any standard PC computer with.NET framework installed.

  1. Causal mapping

    DEFF Research Database (Denmark)

    Rasmussen, Lauge Baungaard

    2006-01-01

    The lecture note explains how to use the causal mapping method as well as the theoretical framework aoosciated to the method......The lecture note explains how to use the causal mapping method as well as the theoretical framework aoosciated to the method...

  2. Single Nucleotide Polymorphisms of CBF4 Locus Region of Arabidopsis thaliana Correspond to Drought Tolerance%拟南芥CBF4基因位点的单核苷酸多态性(SNP)变化与抗旱表型的相应性

    Institute of Scientific and Technical Information of China (English)

    郝岗平; 吴忠义; 陈茂盛; 曹鸣庆; Dominique Brunnel; Georges Pelletier; 黄丛林; 杨清

    2004-01-01

    以生长于不同生态气候条件下的17个拟南芥(Arabidopsis thaliana)核心生态型为材料,分析了它们的相对抗旱性和抗旱转录因子CBF4基因的单核苷酸多态性(SNP).结果表明,不同的拟南芥生态型具有差异明显的抗旱性.与拟南芥Columbia生态型相比,25av、203av和244av生态型的CBF4基因位点具有高密度的SNP和插入/缺失(Indel),多态性的频率为每35.8 bp1个SNP,每143 bp 1个Indel.Tajima's D统计学检验结果显示各区域都不显著,说明该区域核苷酸变化符合中性突变假说,较高的核苷酸多样性是净化选择的结果.基因非编码区的多态性是编码区的4倍,表明编码区承受着更大的选择压力.在编码区,SNP的频率为每96.4bp1个SNP,其中1034位(以GenBankNo.AB015478序列第19 696位的核苷酸为1)碱基变化:G←→T,引起第205位氨基酸变化:gly←→val.而203ay形成的haplotype 6具有4个特异的SNP变化,其中5'端非编码区3个:27位的AG,129位的A←→C,171位的G←→A;3'端非编码区1个:1106位的A←→C.抗旱性鉴定结果表明203av拟南芥是抗旱性最强的一个生态型,研究认为haplotype 6与它较强的抗旱性表型相应.

  3. A bioinformatics insight to rhizobial globins: gene identification and mapping, polypeptide sequence and phenetic analysis, and protein modeling. [v1; ref status: indexed, http://f1000r.es/5ai

    Directory of Open Access Journals (Sweden)

    Reinier Gesto-Borroto

    2015-05-01

    Full Text Available Globins (Glbs are proteins widely distributed in organisms. Three evolutionary families have been identified in Glbs: the M, S and T Glb families. The M Glbs include flavohemoglobins (fHbs and single-domain Glbs (SDgbs; the S Glbs include globin-coupled sensors (GCSs, protoglobins and sensor single domain globins, and the T Glbs include truncated Glbs (tHbs. Structurally, the M and S Glbs exhibit 3/3-folding whereas the T Glbs exhibit 2/2-folding. Glbs are widespread in bacteria, including several rhizobial genomes. However, only few rhizobial Glbs have been characterized. Hence, we characterized Glbs from 62 rhizobial genomes using bioinformatics methods such as data mining in databases, sequence alignment, phenogram construction and protein modeling. Also, we analyzed soluble extracts from Bradyrhizobium japonicum USDA38 and USDA58 by (reduced + carbon monoxide (CO minus reduced differential spectroscopy. Database searching showed that only fhb, sdgb, gcs and thb genes exist in the rhizobia analyzed in this work. Promoter analysis revealed that apparently several rhizobial glb genes are not regulated by a -10 promoter but might be regulated by -35 and Fnr (fumarate-nitrate reduction regulator-like promoters. Mapping analysis revealed that rhizobial fhbs and thbs are flanked by a variety of genes whereas several rhizobial sdgbs and gcss are flanked by genes coding for proteins involved in the metabolism of nitrates and nitrites and chemotaxis, respectively. Phenetic analysis showed that rhizobial Glbs segregate into the M, S and T Glb families, while structural analysis showed that predicted rhizobial SDgbs and fHbs and GCSs globin domain and tHbs fold into the 3/3- and 2/2-folding, respectively. Spectra from B. japonicum USDA38 and USDA58 soluble extracts exhibited peaks and troughs characteristic of bacterial and vertebrate Glbs thus indicating that putative Glbs are synthesized in B. japonicum USDA38 and USDA58.

  4. The shallow structure of the 2009 Mw 6.1 L'Aquila earthquake fault-system (Italy): new insights from integrated high-resolution refraction tomography and detailed geologic mapping

    Science.gov (United States)

    Villani, Fabio; Improta, Luigi; Pucci, Stefano; Civico, Riccardo; Pantosti, Daniela

    2015-04-01

    The 6 April 2009 Mw 6.1 L'Aquila earthquake (central Italy) was caused by the Paganica Fault, which belongs to a ~20 km long network of normal faults (Paganica-San Demetrio Fault System, PSDFS). The hangingwall of the PSDFS hosts a wide Quaternary continental basin (Middle Aterno valley) with complex geometry, structural setting and sedimentary evolution. Before the 2009 earthquake, the shallow crustal structure in the epicentral area was poorly known. Here, we report results of a 2-D high-resolution seismic investigation carried out in 2010 in the NE portion of the basin, across the Paganica Fault, in a challenging urban environment. The survey consisted of 5 dense wide-aperture seismic profiles that run NE-SW for a total length of 8 km. Around 80,000 hand-picked first-arrival traveltimes were input to a non-linear multi-scale tomographic inversion. The merged profiles allow depicting a reliable cross-section of the Middle Aterno basin down to ~300 m depth. In addition, we show for the first time P-wave velocity images across the causative fault of the 6 April 2009 earthquake. Interpretation of the Vp tomograms is constrained by a few drillings and by results of a detailed geologic survey. We interpret low-Vp regions (1500-2000 m/s) as lacustrine sediments and higher Vp bodies (Vp up to 3000 m/s) as coarse fluvial and alluvial fan deposits sited above a Meso-Cenozoic carbonate substratum (Vp >3500-4000 m/s) that shows a very irregular morphology. The improved knowledge of the Middle Aterno valley geological setting together with new tomographic Vp images yield new insights on the buried structure and long-term evolution of two small basins (Bazzano and Paganica basins) crossed by the seismic lines. In particular, the Paganica basin developed since Early-Middle Pleistocene due to the Paganica SW-dipping master fault and its splays. Seismic imaging revealed that the basin infill consists almost exclusively of coarse alluvial fan deposits. We were able to detect 2

  5. Affective Maps

    DEFF Research Database (Denmark)

    Salovaara-Moring, Inka

    . In particular, mapping environmental damage, endangered species, and human made disasters has become one of the focal point of affective knowledge production. These ‘more-than-humangeographies’ practices include notions of species, space and territory, and movement towards a new political ecology. This type...... of environmental knowledge production. It uses InfoAmazonia, the databased platform on Amazon rainforests, as an example of affective geo-visualization within information mapping that enhances embodiment in the experience of the information. Amazonia is defined as a digitally created affective (map)space within...

  6. Mapping Biodiversity.

    Science.gov (United States)

    World Wildlife Fund, Washington, DC.

    This document features a lesson plan that examines how maps help scientists protect biodiversity and how plants and animals are adapted to specific ecoregions by comparing biome, ecoregion, and habitat. Samples of instruction and assessment are included. (KHR)

  7. Rethinking maps

    OpenAIRE

    Kitchin, Rob; Dodge, Martin

    2007-01-01

    In this paper we argue that cartography is profitably conceived as a processual, rather than representational, science. Building on recent analysis concerning the philosophical underpinnings of cartography we question the ontological security of maps, contending that it is productive to rethink cartography as ontogenetic in nature; that is maps emerge through practices and have no secure ontological status. Drawing on the concepts of transduction and technicity we contend that ...

  8. High-resolution brain SPECT imaging in attention deficit hyperactivity disorder children without comorbidity: quantitative analysis using statistical parametric mapping(SPM)

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Myoung Hoon; Yoon, Seok Nam; Oh, Eun Young [Ajou University School of Medicine, Suwon (Korea, Republic of); Chung, Young Ki; Hwang, Isaac; Lee, Jae Sung [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2002-07-01

    We examined the abnormalities of regional cerebral blood flow(rCBF) in children with attention deficit hyperactivity disorder(ADHD) without comorbidity using statistical parametric mapping(SPM) method. We used the patients with not compatible to DSM-IV diagnostic criteria of ADHD and normal rCBF pattern in visual analysis as normal control children. Tc-99m ECD brain SPECT was performed on 75 patients (M:F=64:11, 10.0{+-}2.5y) with the DSM-IV diagnostic criteria of ADHD and 13 normal control children (M:F=9:4, 10.3{+-}4.1y). Using SPM method, we compared patient group's SPECT images with those of 13 control subjects and measured the extent of the area with significant hypoperfusion(p<0.01) in predefined 34 cerebral regions. Only on area of left temporal lobe showed significant hypoperfusion in ADHD patients without comorbidity (n=75) compared with control subjects(n=13). (n=75, p<0.01, extent threshold=16). rCBF of left temporal area was decreased in ADHD group without comorbidity, such as tic, compared with control group.

  9. Conceptual change with refutational maps

    Science.gov (United States)

    Liu, Qing

    The purpose of this research was to explore the effect of studying refutational maps on conceptual change. Refutational maps are diagrams that explicitly present correct conceptions and commonly held misconceptions. A sample of 120 participants was randomly assigned into three groups: a refutational map group, a refutational text group and a non-refutational text group. A posttest was conducted to examine participants' performance on free recall and learning transfer measures. Results revealed that the refutational map group outperformed the other two groups on the free recall test. On the transfer essay test, the refutational map group outperformed the non-refutational text group but was not statistically detectably different from the refutational text group. On the transfer multiple-choice test, differences in the mean scores of the three treatment groups were not statistically detected. The research also found that need for cognition and logical thinking predicted the acquisition of scientific concepts, and students with lower logical thinking ability benefited more from learning the refutational map. These findings provide an insight into prior research on conceptual change and have instructional implications for incorporating effective cognitive tools in science classrooms. Key words: refutational map; conceptual change; need for cognition; logical thinking

  10. Mapping Deeply

    Directory of Open Access Journals (Sweden)

    Denis Wood

    2015-08-01

    Full Text Available This is a description of an avant la lettre deep mapping project carried out by a geographer and a number of landscape architecture students in the early 1980s. Although humanists seem to take the “mapping” in deep mapping more metaphorically than cartographically, in this neighborhood mapping project, the mapmaking was taken literally, with the goal of producing an atlas of the neighborhood. In this, the neighborhood was construed as a transformer, turning the stuff of the world (gas, water, electricity into the stuff of individual lives (sidewalk graffiti, wind chimes, barking dogs, and vice versa. Maps in the central transformer section of the atlas were to have charted this process in action, as in one showing the route of an individual newspaper into the neighborhood, then through the neighborhood to a home, and finally, as trash, out of the neighborhood in a garbage truck; though few of these had been completed when the project concluded in 1986. Resurrected in 1998 in an episode on Ira Glass’ This American Life, the atlas was finally published, as Everything Sings: Maps for a Narrative Atlas, in 2010 (and an expanded edition in 2013.

  11. Insight cognitif et schizophrenie

    OpenAIRE

    W. El-Hage; Lafay, N.; Wassouf, I.; Jaafari, N.

    2011-01-01

    Resume La schizophrenie est souvent associee a une meconnaissance du trouble severe et persistante. Ce deficit d?insight est correle a l?hypofrontalite mais independant du pronostic de la maladie ou du quotient intellectuel. L?insight cognitif est defini comme la difference entre la capacite de reflexion sur soi et la certitude dans cette reflexion. Cette capacite est trouvee diminuee dans la schizophrenie mais augmentee en cas de depression. Ainsi, la schizophrenie avec comorbidit...

  12. Parametric mapping

    Science.gov (United States)

    Branch, Allan C.

    1998-01-01

    Parametric mapping (PM) lies midway between older and proven artificial landmark based guidance systems and yet to be realized vision based guidance systems. It is a simple yet effective natural landmark recognition system offering freedom from the need for enhancements to the environment. Development of PM systems can be inexpensive and rapid and they are starting to appear in commercial and industrial applications. Together with a description of the structural framework developed to generically describe robot mobility, this paper illustrates clearly the parts of any mobile robot navigation and guidance system and their interrelationships. Among other things, the importance of the richness of the reference map, and not necessarily the sensor map, is introduced, the benefits of dynamic path planners to alleviate the need for separate object avoidance, and the independence of the PM system to the type of sensor input is shown.

  13. CALS Mapping

    DEFF Research Database (Denmark)

    Collin, Ib; Nielsen, Povl Holm; Larsen, Michael Holm

    1998-01-01

    To enhance the industrial applications of CALS, CALS Center Danmark has developed a cost efficient and transparent assessment, CALS Mapping, to uncover the potential of CALS - primarily dedicated to small and medium sized enterprises. The idea behind CALS Mapping is that the CALS State...... of the enterprise is compared with a Reference Enterprise Model (REM). The REM is a CALS idealised enterprise providing full product support throughout the extended enterprise and containing different manufacturing aspects, e.g. component industry, process industry, and one-piece production. This CALS idealised...... enterprise is, when applied in a given organisation modified with respect to the industry regarded, hence irrelevant measure parameters are eliminated to avoid redundancy. This assessment of CALS Mapping, quantify the CALS potential of an organisation with the purpose of providing decision support to the top...

  14. Mapping Resilience

    DEFF Research Database (Denmark)

    Carruth, Susan

    2015-01-01

    relationship between resilience and energy planning, suggesting that planning in, and with, time is a core necessity in this domain. It then reviews four examples of graphically mapping with time, highlighting some of the key challenges, before tentatively proposing a graphical language to be employed by...

  15. Mole Mapping.

    Science.gov (United States)

    Crippen, Kent J.; Curtright, Robert D.; Brooks, David W.

    2000-01-01

    The abstract nature of the mole and its applications to problem solving make learning the concept difficult for students, and teaching the concept challenging for teachers. Presents activities that use concept maps and graphing calculators as tools for solving mole problems. (ASK)

  16. Mapping filmmaking

    DEFF Research Database (Denmark)

    Gilje, Øystein; Frølunde, Lisbeth; Lindstrand, Fredrik;

    2010-01-01

    This chapter concerns mapping patterns in regards to how young filmmakers (age 15 – 20) in the Scandinavian countries learn about filmmaking. To uncover the patterns, we present portraits of four young filmmakers who participated in the Scandinavian research project Making a filmmaker. The focus ...

  17. Participatory maps

    DEFF Research Database (Denmark)

    Salovaara-Moring, Inka

    looks at computer-assisted cartography as part of environmental knowledge production. It uses InfoAmazonia, the databased platform on Amazon rainforests, as an example of affective geo-visualization within information mapping that enhances embodiment in the experience of the information. Amazonia...

  18. Energetic map

    International Nuclear Information System (INIS)

    This report explains the energetic map of Uruguay as well as the different systems that delimits political frontiers in the region. The electrical system importance is due to the electricity, oil and derived , natural gas, potential study, biofuels, wind and solar energy

  19. Inside PixInsight

    CERN Document Server

    Keller, Warren A

    2016-01-01

    In this book, Warren Keller reveals the secrets of astro-image processing software PixInsight in a practical and easy to follow manner, allowing the reader to produce stunning astrophotographs from even mediocre data. As the first comprehensive post-processing platform to be created by astro-imagers for astro-imagers, it has for many, replaced the generic graphics editors as the software of choice. With clear instructions from Keller, astrophotographers can get the most from its tools to create amazing images. Capable of complex post-processing routines, PixInsight is also an advanced pre-processing software, through which astrophotographers calibrate and stack their exposures into completed master files.This is the most comprehensive resource on PixInsight to date. With screenshots to help illustrate the process, it is a vital guide.

  20. OpenGL Insights

    CERN Document Server

    Cozzi, Patrick

    2012-01-01

    Get Real-World Insight from Experienced Professionals in the OpenGL Community With OpenGL, OpenGL ES, and WebGL, real-time rendering is becoming available everywhere, from AAA games to mobile phones to web pages. Assembling contributions from experienced developers, vendors, researchers, and educators, OpenGL Insights presents real-world techniques for intermediate and advanced OpenGL, OpenGL ES, and WebGL developers. Go Beyond the Basics The book thoroughly covers a range of topics, including OpenGL 4.2 and recent extensions. It explains how to optimize for mobile devices, explores the design

  1. Comparison of normal adult and children brain SPECT imaging using statistical parametric mapping(SPM)

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Myoung Hoon; Yoon, Seok Nam; Joh, Chul Woo; Lee, Dong Soo [Ajou University School of Medicine, Suwon (Korea, Republic of); Lee, Jae Sung [Seoul national University College of Medicine, Seoul (Korea, Republic of)

    2002-07-01

    This study compared rCBF pattern in normal adult and normal children using statistical parametric mapping (SPM). The purpose of this study was to determine distribution pattern not seen visual analysis in both groups. Tc-99m ECD brain SPECT was performed in 12 normal adults (M:F=11:1, average age 35 year old) and 6 normal control children (M:F=4:2, 10.5{+-}3.1y) who visited psychiatry clinic to evaluate ADHD. Their brain SPECT revealed normal rCBF pattern in visual analysis and they were diagnosed clinically normal. Using SPM method, we compared normal adult group's SPECT images with those of 6 normal children subjects and measured the extent of the area with significant hypoperfusion and hyperperfusion (p<0.001, extent threshold=16). The areas of both angnlar gyrus, both postcentral gyrus, both superior frontal gyrus, and both superior parietal lobe showed significant hyperperfusion in normal adult group compared with normal children group. The areas of left amygdala gyrus, brain stem, both cerebellum, left globus pallidus, both hippocampal formations, both parahippocampal gyrus, both thalamus, both uncus, both lateral and medial occipitotemporal gyrus revealed significantly hyperperfusion in the children. These results demonstrated that SPM can say more precise anatomical area difference not seen visual analysis.

  2. MAPPING INNOVATION

    DEFF Research Database (Denmark)

    Thuesen, Christian Langhoff; Koch, Christian

    2011-01-01

    By adopting a theoretical framework from strategic niche management research (SNM) this paper presents an analysis of the innovation system of the Danish Construction industry. The analysis shows a multifaceted landscape of innovation around an existing regime, built around existing ways of working...... and developed over generations. The regime is challenged from various niches and the socio-technical landscape through trends as globalization. Three niches (Lean Construction, BIM and System Deliveries) are subject to a detailed analysis showing partly incompatible rationales and various degrees of innovation...... potential. The paper further discusses how existing policymaking operates in a number of tensions one being between government and governance. Based on the concepts from SNM the paper introduces an innovation map in order to support the development of meta-governance policymaking. By mapping some...

  3. Cognitive maps

    DEFF Research Database (Denmark)

    Minder, Bettina; Laursen, Linda Nhu; Lassen, Astrid Heidemann

    2014-01-01

    This paper identifies three different perspectives on the relationship between design and innovation and explains implication of these different world-views of the interrelations between innovation and design. The study is based on empirical data from a series of semi-structured expert interviews...... of the interrelation becomes increasingly important. This paper seeks to clarify this interrelation and discuss how design is used in innovation.......This paper identifies three different perspectives on the relationship between design and innovation and explains implication of these different world-views of the interrelations between innovation and design. The study is based on empirical data from a series of semi-structured expert interviews....... Conceptual clustering is used to analyse and order information according to concepts or variables from within the data. The cognitive maps identified are validated through the comments of some of the same experts. The study presents three cognitive maps and respective world-views explaining how the design...

  4. The influence of hyperoxia on regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV) and cerebral blood flow velocity in the middle cerebral artery (CBFVMCA) in human volunteers.

    Science.gov (United States)

    Kolbitsch, Christian; Lorenz, Ingo H; Hörmann, Christoph; Hinteregger, Martin; Löckinger, Alexander; Moser, Patrizia L; Kremser, Christian; Schocke, Michael; Felber, Stephan; Pfeiffer, Karl P; Benzer, Arnulf

    2002-09-01

    Conflicting results reported on the effects of hyperoxia on cerebral hemodynamics have been attributed mainly to methodical and species differences. In the present study contrast-enhanced magnetic resonance imaging (MRI) perfusion measurement was used to analyze the influence of hyperoxia (fraction of inspired oxygen (FiO2) = 1.0) on regional cerebral blood flow (rCBF) and regional cerebral blood volume (rCBV) in awake, normoventilating volunteers (n = 19). Furthermore, the experiment was repeated in 20 volunteers for transcranial Doppler sonography (TCD) measurement of cerebral blood flow velocity in the middle cerebral artery (CBFV(MCA)). When compared to normoxia (FiO2 = 0.21), hyperoxia heterogeneously influenced rCBV (4.95 +/- 0.02 to 12.87 +/- 0.08 mL/100g (FiO2 = 0.21) vs. 4.50 +/- 0.02 to 13.09 +/- 0.09 mL/100g (FiO2 = 1.0). In contrast, hyperoxia diminished rCBF in all regions (68.08 +/- 0.38 to 199.58 +/- 1.58 mL/100g/min (FiO2 = 0.21) vs. 58.63 +/- 0.32 to 175.16 +/- 1.51 mL/100g/min (FiO2 = 1.0)) except in parietal and left frontal gray matter. CBFV(MCA) remained unchanged regardless of the inspired oxygen fraction (62 +/- 9 cm/s (FiO2 = 0.21) vs. 64 +/- 8 cm/s (FiO2 = 1.0)). Finding CBFV(MCA) unchanged during hyperoxia is consistent with the present study's unchanged rCBF in parietal and left frontal gray matter. In these fronto-parietal regions predominantly fed by the middle cerebral artery, the vasoconstrictor effect of oxygen was probably counteracted by increased perfusion of foci of neuronal activity controlling general behavior and arousal. PMID:12413599

  5. Functional optical coherence tomography for high-resolution mapping of cilia beat frequency in the mouse oviduct in vivo

    Science.gov (United States)

    Wang, Shang; Burton, Jason C.; Behringer, Richard R.; Larina, Irina V.

    2016-02-01

    Since mouse is a superior model for genetic analysis of human disorders, reproductive studies in mice have significant implications on further understanding of fertility and infertility in humans. Fertilized oocytes are transported through the reproductive tract by motile cilia lining the lumen of the oviduct as well as by oviduct contractions. While the role of cilia is well recognized, ciliary dynamics in the oviduct is not well understood, largely owing to the lack of live imaging approaches. Here, we report in vivo micro-scale mapping of cilia and cilia beat frequency (CBF) in the mouse oviduct using optical coherence tomography (OCT). This functional imaging method is based on spectral analysis of the OCT speckle variations produced by the beat of cilia in the oviduct, which does not require exogenous contrast agents. Animal procedures similar to the ones used for production of transgenic mice are utilized to expose the reproductive organs for imaging in anesthetized females. In this paper, we first present in vivo structural imaging of the mouse oviduct capturing the oocyte and the preimplantation embryo and then show the result of depth-resolved high-resolution CBF mapping in the ampulla of the live mouse. These data indicate that this structural and functional OCT imaging approach can be a useful tool for a variety of live investigations of mammalian reproduction and infertility.

  6. Mapping the potential of cross-border cooperation in West Africa

    DEFF Research Database (Denmark)

    Walther, Olivier; Vollmer, Sebastian

    2015-01-01

    Mapping the socio-economic potential of border regions can provide great insights as to where cross-border co-operation could be intensified in West Africa.......Mapping the socio-economic potential of border regions can provide great insights as to where cross-border co-operation could be intensified in West Africa....

  7. A tandem array of CBF/DREB1 genes is located in a major freezing tolerance QTL region on Medicago truncatula chromosome 6

    OpenAIRE

    Tayeh, Nadim; Bahrman, Nasser; Sellier, Hélène; Bluteau, Aurélie; Blassiau, Christelle; Fourment, Joelle; Bellec, Arnaud; Debellé, Frederic; Lejeune-Henaut, Isabelle; Delbreil, Bruno

    2013-01-01

    Background Freezing provokes severe yield losses to different fall-sown annual legumes. Understanding the molecular bases of freezing tolerance is of great interest for breeding programs. Medicago truncatula Gaertn. is an annual temperate forage legume that has been chosen as a model species for agronomically and economically important legume crops. The present study aimed to identify positional candidate genes for a major freezing tolerance quantitative trait locus that was previously mapped...

  8. Insight into Phenomena of Symmetry Breaking Bifurcation

    Institute of Scientific and Technical Information of China (English)

    FANG Tong; ZHANG Ying

    2008-01-01

    @@ We show that symmetry-breaking (SB) bifurcation is just a transition of different forms of symmetry, while still preserving system's symmetry. SB bifurcation always associates with a periodic saddle-node bifurcation, identifiable by a zero maximum of the top Lyapunov exponent of the system. In addition, we show a significant phase portrait of a newly born periodic saddle and its stable and unstable invariant manifolds, together with their neighbouring flow pattern of Poincaré mapping points just after the periodic saddle-node bifurcation, thus gaining an insight into the mechanism of SB bifurcation.

  9. Noninvasive method for mapping CVR in moyamoya disease using ASL-MRI

    Energy Technology Data Exchange (ETDEWEB)

    Noguchi, Tomoyuki, E-mail: tnogucci@radiol.med.kyushu-u.ac.jp [Department of Radiology, National center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-ku, Tokyo 162-8655 (Japan); Department of Radiology, Faculty of Medicine and Graduate School of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501 (Japan); Kawashima, Masatou, E-mail: m996kawa@cc.saga-u.ac.jp [Department of Neurosugery, Faculty of Medicine and Graduate School of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501 (Japan); Nishihara, Masashi, E-mail: nishiham@cc.saga-u.ac.jp [Department of Radiology, Faculty of Medicine and Graduate School of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501 (Japan); Egashira, Yoshiaki, E-mail: bunta1974@yahoo.co.jp [Department of Radiology, Faculty of Medicine and Graduate School of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501 (Japan); Azama, Shinya, E-mail: azama-ssam-71257@b2.bunbun.ne.jp [Department of Radiology, Faculty of Medicine and Graduate School of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501 (Japan); Irie, Hiroyuki, E-mail: irie@cc.saga-u.ac.jp [Department of Radiology, Faculty of Medicine and Graduate School of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501 (Japan)

    2015-06-15

    Highlights: • A clinical use of a pulse-wave-synchronized ASL-MRI (pulsy ASL-MRI) was proposed. • Resting IMP-SPECT correlated with pulsy ASL-MRI in moyamoya disease. • ASL-MRI could measure cerebrovascular reserve noninvasively in moyamoya disease. - Abstract: Purpose: To project a noninvasive method for mapping cerebrovascular reserve (CVR) in moyamoya disease (MMD) using ASL-MRI. Methods: 16 MMD patients underwent cerebral blood flow (CBF) examinations by standard ASL-MRI, pulse-wave-synchronized ASL-MRI (pulsy ASL-MRI) which tagged the arterial blood coincident with a peak of a pulse wave, and single photon emission computed tomography (SPECT) imagings with iodine-123-N-isopropyl-p-iodoamphetamine in the resting (rest-IMP) and after acetazolamide challenge (ACZ-IMP). Hemispheric 32-sided cerebral blood flow (CBF) values were measured with normalized CBF maps created from standard ASL-MRI (standard-ASL value), pulsy ASL-MRI (pulsy-ASL value), rest-IMP (rest-IMP value), and ACZ-IMP (ACZ-IMP value). CVR based on rest-IMP and ACZ-IMP values (IMP-CVR) was calculated. ASL-CVR was also calculated on the basis of corrected standard-ASL values and pulsy-ASL values, which were adjusted to the ACZ-IMP values and rest-IMP values, respectively, by the least-squares method. We assessed the relationships between rest-IMP values and pulsy-ASL values, ACZ-IMP values and standard-ASL values, and IMP-CVR and ASL-CVR. Results: Significant relationships were observed between rest-IMP values and pulsy-ASL values (correlation coefficient (r = 0.557, p < 0.01)), ACZ-IMP values and standard-ASL values (r = 0.825, p < 0.01), and IMP-CVR and ASL-CVR (r = 0.736, p < 0.01). Conclusions: ASL-MRI is equivalent to SPECT and that it might serve as a noninvasive method for mapping CVR in MMD.

  10. Human brain mapping under increasing cognitive complexity using regional cerebral blood flow measurements and positron emission tomography.

    Science.gov (United States)

    Law, Ian

    2007-11-01

    Measurement of the regional cerebral blood flow (rCBF) is an important parameter in the evaluation of cerebral function. With positron emission tomography (PET) rCBF has predominantly been quantified using the short-lived radiotracer oxygen-15 labelled water (H 2 15 O) and an adaptation of the Kety one-tissue compartment autoradiographic model. The values attained in putative grey matter, however, are systematically underestimated because of the limited scanner resolution. For this reason we applied a dynamic kinetic two-tissue compartment model including a fast and a slow flow component each with a perfusable tissue fraction. In the fast component rCBF was 2-2.5 times greater than grey matter values using traditional autoradiography in both human and monkey. Visual stimulation in human gave a corrected rCBF increase of approximately 40%. Visual stimulation was also used to indirectly validate carbon-10 labelled carbondioxide ( 10 CO 2 ), a new very short-lived rCBF PET tracer with a half-life of only 19.3 seconds. This allowed an increase in the number of independent PET scans per subject from 12-14 using H 2 15 O to 64 using 10 CO 2 . The experiment demonstrated a maximal activation response in the visual cortex at a 10-15 Hz stimulation frequency. The use of the rCBF PET mapping technique is illustrated by studies of the organization of language and the oculomotor system. With respect to the former, we found confirmation of neuropsychological evidence of the involvement of the left supramarginal/angular gyrus in reading in Japanese of a phonologically based script system, Kana, and of the left posterior inferior temporal gyrus in reading of a morphogram based script system, Kanji. Concerning the organization of the oculomotor system we found overlapping areas in fronto-parietal cortex involved in maintaining visual fixation, and performing visually guided and imagined eye movements. These data show that overt eye movements are not a prerequisite of the

  11. Map of the Physical Sciences

    Energy Technology Data Exchange (ETDEWEB)

    Boyack, Kevin W.

    1999-07-02

    Various efforts to map the structure of science have been undertaken over the years. Using a new tool, VxInsight{trademark}, we have mapped and displayed 3000 journals in the physical sciences. This map is navigable and interactively reveals the structure of science at many different levels. Science mapping studies are typically focused at either the macro-or micro-level. At a macro-level such studies seek to determine the basic structural units of science and their interrelationships. The majority of studies are performed at the discipline or specialty level, and seek to inform science policy and technical decision makers. Studies at both levels probe the dynamic nature of science, and the implications of the changes. A variety of databases and methods have been used for these studies. Primary among databases are the citation indices (SCI and SSCI) from the Institute for Scientific Information, which have gained widespread acceptance for bibliometric studies. Maps are most often based on computed similarities between journal articles (co-citation), keywords or topics (co-occurrence or co-classification), or journals (journal-journal citation counts). Once the similarity matrix is defined, algorithms are used to cluster the data.

  12. Multichannel quantum defect theory: a quantum Poincaré map

    OpenAIRE

    Leyvraz, F.; Méndez-Sánchez, R. A.; Lombardi, M.; Seligman, T. H.

    2000-01-01

    International audience The multichannel quantum defect theory (MQDT) can be reinterpreted as a quantum Poincaré map in representation of angular momentum. This has two important implications: we have a paradigm of a true quantum Poincaré map without semi-classical input and we get an entirely new insight into the significance of MQDT.

  13. World energy insight 2011

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-11-15

    The World Energy Insight 2011 is the official publication of the World Energy Council. It includes interviews, articles and case studies from a distinguished panel of World Energy Council Officers, CEOs, government ministers, academics and opinion formers from all areas of the energy sector and provides perspectives from around the globe. Government, industry and NGO's offer both policy and technology perspectives. The insights within this publication add to the work that WEC is doing to provide the forum for energy leaders, along with the on-going WEC studies and programmes on Energy Policies, 2050 Energy Scenarios, Energy Resources & Technologies, Energy for Urban Innovation, Rules Of Energy Trade and Global Energy Access.

  14. An Integrated Map of Soybean Physical Map and Genetic Map

    Institute of Scientific and Technical Information of China (English)

    QI Zhaoming; LI Hui; WU Qiong; SUN Yanan; LIU Chunyan; HU Guohua; CHEN Qingshan

    2009-01-01

    Soybean is a major crop in the world, and it is a main source of plant proteins and oil. A lot of soybean genetic maps and physical maps have been constructed, but there are no integrated map between soybean physical map and genetic map. In this study, soybean genome sequence data, released by JGI (US Department of Energy's Joint Genome Institute), had been downloaded. With the software Blast 2.2.16, a total of 161 super sequences were mapped on the soybean public genetic map to construct an integrated map. The length of these super sequences accounted for 73.08% of all the genome sequence. This integrated map could be used for gene cloning, gene mining, and comparative genome of legume.

  15. Update on INSIGHTS Development

    Energy Technology Data Exchange (ETDEWEB)

    Not Listed; Eric Burgett

    2011-09-01

    INSIGHTS is a transformational separate effects testing capability to perform in situ irradiation studies and characterization of the microscale behavior of nuclear fuel materials under a wide variety of in-pile conditions. Separate effects testing including growth, irradiation, and monitoring of these materials, and encompasses the full science based approach for fuels development from the nanoscale to the mesoscale behavior of the sample material and other defects driven by the modeling and simulation efforts of INL.

  16. Follow-up findings in regional cerebral blood flow (r-CBF)-SPECT in a case of idiopathic childhood hemidystonia. Functional neuroimaging and pathophysiological implications

    International Nuclear Information System (INIS)

    A 9 1/2-year-old girl suffered from intermitting tremor and jitteriness of her left hand and oral muscles every 4 to 6 weeks with long lasting episodes. Clinically myoclonias and dystonic positioning of the left arm, hand and facial muscles were seen. No evidence of trauma, infection or inborn errors of metabolism was found. Successful therapy with carbamazepine was initiated while L-DOPA failed. An ictal 99m-Tc-HMPAO-SPECT showed severe asymmetry with focal hyperperfusion of the contralateral right thalamus and basal ganglia as well as of the bifrontal cortex, whereas no anatomical lesions were found by MRI. In contrast, an interictally performed 99m-Tc-HMPAO SPECT showed hypoperfusion or the right thalamus and normalisation of the frontal perfusion under medical treatment. These 99m-Tc-HMPAO-SPECT findings may provide new insights into the localisation and pathophysiological pathways of idiopathic childhood dystonia. (orig.)

  17. The politics of insight

    Science.gov (United States)

    Salvi, Carola; Cristofori, Irene; Grafman, Jordan; Beeman, Mark

    2016-01-01

    Previous studies showed that liberals and conservatives differ in cognitive style. Liberals are more flexible, and tolerant of complexity and novelty, whereas conservatives are more rigid, are more resistant to change, and prefer clear answers. We administered a set of compound remote associate problems, a task extensively used to differentiate problem-solving styles (via insight or analysis). Using this task, several researches have proven that self-reports, which differentiate between insight and analytic problem-solving, are reliable and are associated with two different neural circuits. In our research we found that participants self-identifying with distinct political orientations demonstrated differences in problem-solving strategy. Liberals solved significantly more problems via insight instead of in a step-by-step analytic fashion. Our findings extend previous observations that self-identified political orientations reflect differences in cognitive styles. More specifically, we show that type of political orientation is associated with problem-solving strategy. The data converge with previous neurobehavioural and cognitive studies indicating a link between cognitive style and the psychological mechanisms that mediate political beliefs. PMID:26810954

  18. The politics of insight.

    Science.gov (United States)

    Salvi, Carola; Cristofori, Irene; Grafman, Jordan; Beeman, Mark

    2016-06-01

    Previous studies showed that liberals and conservatives differ in cognitive style. Liberals are more flexible, and tolerant of complexity and novelty, whereas conservatives are more rigid, are more resistant to change, and prefer clear answers. We administered a set of compound remote associate problems, a task extensively used to differentiate problem-solving styles (via insight or analysis). Using this task, several researches have proven that self-reports, which differentiate between insight and analytic problem-solving, are reliable and are associated with two different neural circuits. In our research we found that participants self-identifying with distinct political orientations demonstrated differences in problem-solving strategy. Liberals solved significantly more problems via insight instead of in a step-by-step analytic fashion. Our findings extend previous observations that self-identified political orientations reflect differences in cognitive styles. More specifically, we show that type of political orientation is associated with problem-solving strategy. The data converge with previous neurobehavioural and cognitive studies indicating a link between cognitive style and the psychological mechanisms that mediate political beliefs. PMID:26810954

  19. Mapping marginality hotspots: Geographical targeting for poverty reduction

    OpenAIRE

    Graw, Valerie; Ladenburger, Christine

    2012-01-01

    This mapping approach aims to make the marginalized and poor visible by identifying areas with difficult biophysical and socio-economic conditions. Mapping using different data sources and data types gives deeper insight into possible causal interlinkages and offers the opportunity for comprehensive analysis. The maps highlight areas where different dimensions of marginality overlap – the marginality hotspots – based on proxies for marginality dimensions representing different spheres of life...

  20. Projective mapping

    DEFF Research Database (Denmark)

    Dehlholm, Christian; Brockhoff, Per B.; Bredie, Wender Laurentius Petrus

    2012-01-01

    the applied framework, semantic restrictions, the choice of type of assessors and the validation of product separations. The applied framework concerns the response surface as presented to the assessor in different shapes, e.g. rectangular, square or round. Semantic restrictions are a part of the assessor...... instructions and influence heavily the product placements and the descriptive vocabulary (Dehlholm et.al., 2012b). The type of assessors performing the method influences results with an extra aspect in Projective Mapping compared to more analytical tests, as the given spontaneous perceptions are much dependent...... on the assessor’s way of thinking. Furthermore, a suggestion for validating product separations is proposed for the case where Multiple Factor Analysis is chosen for data analysis (Dehlholm, Brockhoff & Bredie, 2012a)....

  1. 2014 update of the U.S. national seismic hazard maps

    Science.gov (United States)

    Petersen, Mark D.; Moschetti, Morgan P.; Powers, Peter M.; Mueller, Charles S.; Haller, Kathleen M.; Frankel, Arthur D.; Zeng, Yuehua; Rezaeian, Sanaz; Harmsen, Stephen C.; Boyd, Oliver S.; Field, Ned; Chen, R; Rukstales, Kenneth S.; Luco, Nicolas; Wheeler, Russell L.; Olsen, Anna H.

    2014-01-01

    We held 8 regional and topical workshops across the U.S. to gather information for these maps. The maps were available to the public for comment during a 60-day period. A Steering Committee (9 experts) was assembled to review the inputs and results and provide additional insights. The maps have been presented at several professional meetings.

  2. Visual analytics on eye movement data reveal search patterns on dynamic and interactive maps

    OpenAIRE

    Ooms, Kristien; Andrienko, Gennady; Andrienko, Natalia; De Maeyer, Philippe; Fack, Veerle

    2010-01-01

    In this paper the results of a visual analytics approach on eye movement data are described which allows detecting underlying patterns in the scanpaths of the user’s during a visual search on a map. These patterns give insights in the user his cognitive processes or his mental map while working with interactive maps.

  3. Modeling for Insights

    Energy Technology Data Exchange (ETDEWEB)

    Jacob J. Jacobson; Gretchen Matthern

    2007-04-01

    System Dynamics is a computer-aided approach to evaluating the interrelationships of different components and activities within complex systems. Recently, System Dynamics models have been developed in areas such as policy design, biological and medical modeling, energy and the environmental analysis, and in various other areas in the natural and social sciences. The real power of System Dynamic modeling is gaining insights into total system behavior as time, and system parameters are adjusted and the effects are visualized in real time. System Dynamic models allow decision makers and stakeholders to explore long-term behavior and performance of complex systems, especially in the context of dynamic processes and changing scenarios without having to wait decades to obtain field data or risk failure if a poor management or design approach is used. The Idaho National Laboratory recently has been developing a System Dynamic model of the US Nuclear Fuel Cycle. The model is intended to be used to identify and understand interactions throughout the entire nuclear fuel cycle and suggest sustainable development strategies. This paper describes the basic framework of the current model and presents examples of useful insights gained from the model thus far with respect to sustainable development of nuclear power.

  4. Human Mind Maps

    Science.gov (United States)

    Glass, Tom

    2016-01-01

    When students generate mind maps, or concept maps, the maps are usually on paper, computer screens, or a blackboard. Human Mind Maps require few resources and little preparation. The main requirements are space where students can move around and a little creativity and imagination. Mind maps can be used for a variety of purposes, and Human Mind…

  5. Follow-up findings in regional cerebral blood flow (r-CBF)-SPECT in a case of idiopathic childhood hemidystonia. Functional neuroimaging and pathophysiological implications

    Energy Technology Data Exchange (ETDEWEB)

    Fiedler, A.; Aderbauer, J.; Segerer, H. [St. Hedwig Hospital, Regensburg (Germany). Dept. of Pediatrics; Marienhagen, J.; Bock, E.; Eilles, C. [Univ. Hospital, Regensburg (Germany). Dept. of Nuclear Medicine

    1999-05-01

    A 9 1/2-year-old girl suffered from intermitting tremor and jitteriness of her left hand and oral muscles every 4 to 6 weeks with long lasting episodes. Clinically myoclonias and dystonic positioning of the left arm, hand and facial muscles were seen. No evidence of trauma, infection or inborn errors of metabolism was found. Successful therapy with carbamazepine was initiated while L-DOPA failed. An ictal 99m-Tc-HMPAO-SPECT showed severe asymmetry with focal hyperperfusion of the contralateral right thalamus and basal ganglia as well as of the bifrontal cortex, whereas no anatomical lesions were found by MRI. In contrast, an interictally performed 99m-Tc-HMPAO SPECT showed hypoperfusion or the right thalamus and normalisation of the frontal perfusion under medical treatment. These 99m-Tc-HMPAO-SPECT findings may provide new insights into the localisation and pathophysiological pathways of idiopathic childhood dystonia. (orig.) [Deutsch] Ein 9 1/2jaehriges Maedchen litt an rezidivierenden, langdauernden Schueben von Tremor und Zittern der linken Hand und der perioralen Muskulatur links. Klinisch fanden sich eine dystone Haltung des linken Armes und unerschoepfliche Myoklonien des Armes, der Hand und der Gesichtsmuskulatur links. Trauma, Infektion oder ein Stoffwechseldefekt als Ursache lagen nicht vor. Ein Therapieversuch mit L-DOPA war erfolglos. Unter Gabe von Carbamazepin wurde Beschwerdefreiheit bleibend erreicht. Ein iktuales 99m-Tc-HMPAO-SPECT zeigte eine fokale Hyperperfusion des rechtsseitigen Thalamus und der Basalganglien, sowie des bifrontalen Kortex. Ein interiktuales 99m-Tc-HMPAOSPECT ergab dann eine deutliche Hypoperfusion des rechtseitigen Thalamus bei normalisierter Perfusion des bifrontalen Kortex. Eine kranielle Magnetresonanztomographie (MRI) ergab einen unauffaelligen Befund. Der Vergleich der iktualen und interiktualen Perfusionsverhaeltnisse weist auf neue pathophysiologische Zusammenhaenge bei idiopathischer kindlicher Dystonie hin. (orig.)

  6. Genome Mapping in Plant Comparative Genomics.

    Science.gov (United States)

    Chaney, Lindsay; Sharp, Aaron R; Evans, Carrie R; Udall, Joshua A

    2016-09-01

    Genome mapping produces fingerprints of DNA sequences to construct a physical map of the whole genome. It provides contiguous, long-range information that complements and, in some cases, replaces sequencing data. Recent advances in genome-mapping technology will better allow researchers to detect large (>1kbp) structural variations between plant genomes. Some molecular and informatics complications need to be overcome for this novel technology to achieve its full utility. This technology will be useful for understanding phenotype responses due to DNA rearrangements and will yield insights into genome evolution, particularly in polyploids. In this review, we outline recent advances in genome-mapping technology, including the processes required for data collection and analysis, and applications in plant comparative genomics.

  7. Maps & minds : mapping through the ages

    Science.gov (United States)

    U.S. Geological Survey

    1984-01-01

    Throughout time, maps have expressed our understanding of our world. Human affairs have been influenced strongly by the quality of maps available to us at the major turning points in our history. "Maps & Minds" traces the ebb and flow of a few central ideas in the mainstream of mapping. Our expanding knowledge of our cosmic neighborhood stems largely from a small number of simple but grand ideas, vigorously pursued.

  8. Lunar Map Catalog

    Data.gov (United States)

    National Aeronautics and Space Administration — The Lunar Map Catalog includes various maps of the moon's surface, including Apollo landing sites; earthside, farside, and polar charts; photography index maps;...

  9. Insights on STEM Careers

    Energy Technology Data Exchange (ETDEWEB)

    Wendelberger, Joanne Roth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-11-05

    This presentation will provide career advice for individuals seeking to go beyond just having a job to building a successful career in the areas of Science, Technology, Engineering, and Mathematics. Careful planning can be used to turn a job into a springboard for professional advancement and personal satisfaction. Topics to be addressed include setting priorities, understanding career ladders, making tough choices, overcoming stereotypes and assumptions by others, networking, developing a professional identify, and balancing a career with family and other personal responsibilities. Insights on the transition from individual technical work to leadership will also be provided. The author will draw upon experiences gained in academic, industrial, and government laboratory settings, as well as extensive professional service and community involvement.

  10. Osho - Insights on sex.

    Science.gov (United States)

    Nagaraj, Anil Kumar Mysore

    2013-01-01

    Sex is a mysterious phenomenon, which has puzzled even great sages. Human beings have researched and mastered the biology of sex. But that is not all. Sex needs to be understood from the spiritual perspective too. The vision of Osho is an enlightening experience in this regard. Out of the thousands of lectures, five lectures on sex made Osho most notorious. Born into a Jain family of Madhya Pradesh, Rajneesh, who later wanted himself to be called Osho, is a great master. He has spoken volumes on a wide range of topics ranging from sex to super-consciousness. His contributions in the area of sex are based on the principles of "Tantra" which has its origin from Buddhism. This article focuses on his life and insights on sex, which if understood properly, can be a stepping stone for enlightenment. PMID:23858266

  11. Mapping with the Masses: Google Map Maker

    Science.gov (United States)

    Pfund, J.

    2008-12-01

    After some 15,000 years of map making, which saw the innovations of cardinal directions, map projections for a spherical earth, and GIS analysis, many parts of the world still appear as the "Dark Continent" on modern maps. Google Map Maker intends to shine a light on these areas by tapping into the power of the GeoWeb. Google Map Maker is a website which allows you to collaborate with others on one unified map to add, edit, locate, describe, and moderate map features, such as roads, cities, businesses, parks, schools and more, for certain regions of the world using Google Maps imagery. In this session, we will show some examples of how people are mapping with this powerful tool as well as what they are doing with the data. With Google Map Maker, you can become a citizen cartographer and join the global network of users helping to improve the quality of maps and local information in your region of interest. You are invited to map the world with us!

  12. Concept mapping in lectures.

    OpenAIRE

    Lavery, Janet; Low, Adam

    2008-01-01

    Concept maps are an aid to a deep learning strategy. Developing concept maps would help students understand the relationships between concepts both within a domain and across related domains. To encourage students to explore the use of concept maps, we have integrated concept maps into a module’s lectures. We have trialled: a concept map developed by experts and given to students; another concept map developed collaboratively by the students in an interactive lecture supported by a free-tex...

  13. Insights into business student's book

    CERN Document Server

    Lannon, Michael; Trappe, Tonya

    1993-01-01

    With Challenging reading and listening texts from a range of authentic business sources, New Insights into Business will really engage your students. The thorough language and vocabulary syllabus together with the strong focus on business skills development gives students everything they need to function effectively in the workplace. New Insights into Business is a self-contained course and is also an ideal follow-on to First Insights into Business.

  14. Learning style preference and student aptitude for concept maps.

    Science.gov (United States)

    Kostovich, Carol T; Poradzisz, Michele; Wood, Karen; O'Brien, Karen L

    2007-05-01

    Acknowledging that individuals' preferences for learning vary, faculty in an undergraduate nursing program questioned whether a student's learning style is an indicator of aptitude in developing concept maps. The purpose of this research was to describe the relationship between nursing students' learning style preference and aptitude for concept maps. The sample included 120 undergraduate students enrolled in the adult health nursing course. Students created one concept map and completed two instruments: the Learning Style Survey and the Concept Map Survey. Data included Learning Style Survey scores, grade for the concept map, and grade for the adult health course. No significant difference was found between learning style preference and concept map grades. Thematic analysis of the qualitative survey data yielded further insight into students' preferences for creating concept maps.

  15. Multichannel Quantum Defect Theory a Quantum Poincaré Map

    CERN Document Server

    Leyvraz, F; Lombardi, M; Seligman, T H

    1999-01-01

    The multichannel quantum defect theory (MQDT) can be reinterpreted as a quantum Poincare map in representation of angular momentum. We chose a simplified model for Rydberg molecules where the limit classical map is known and MQDT delivers the exact quantization of this map, which is a finite unitary matrix by construction. The result has two important implications: On one hand we have a paradigm of a true quantum Poincare map without semi-classical input and on the other hand we get an entirely new insight into the significance of MQDT. We obtain a new signature of quantum chaos and a more reliable method to calculate eigenfunctions in MQDT.

  16. Landslide Hazard Zonation Mapping and Comparative Analysis of Hazard Zonation Maps

    Institute of Scientific and Technical Information of China (English)

    S. Sarkar; R. Anbalagan

    2008-01-01

    Landslide hazard zonation mapping at regional level of a large area provides a broad trend of landslide potential zones. A macro level landslide hazard zonation for a small area may provide a better insight into the landslide hazards. The main objective of the present work was to carry out macro landslide hazard zonation mapping on 1:50,000 scale in an area where regional level zonation mapping was conducted earlier. In the previous work the regional landslide hazard zonation maps of Srinagar-Rudraprayag area of Garhwal Himalaya in the state of Uttarakhand were prepared using subjective and objective approaches. In the present work the landslide hazard zonation mapping at macro level was carded out in a small area using a Landslide Hazard Evaluation Factor rating scheme. The hazard zonation map produced by using this technique classifies the area into relative hazard classes in which the high hazard zones well correspond with high frequency of landslides. The results of this map when compared with the regional zonation maps prepared earlier show that application of the present technique identified more details of the hazard zones, which are broadly shown in the earlier zonation maps.

  17. Web mapping: tools and solutions for creating interactive maps of forestry interest

    Directory of Open Access Journals (Sweden)

    Notarangelo G

    2011-12-01

    Full Text Available The spread of geobrowsers as tools for displaying geographically referenced information provides insights and opportunities to those who, not being specialists in Geographic Information Systems, want to take advantage from exploration and communication power offered by these software. Through the use of web services such as Google Maps and the use of suitable markup languages, one can create interactive maps starting from highly heterogeneous data and information. These interactive maps can also be easily distributed and shared with Internet users, because they do not need to use proprietary software nor special skills but only a web browser. Unlike the maps created with GIS, whose output usually is a static image, the interactive maps retain all their features to users advantage. This paper describes a web application that, using the Keyhole Markup Language and the free service of Google Maps, produces choropleth maps relating to some forest indicators estimated by the last Italian National Forest Inventory. The creation of a map is done through a simple and intuitive interface. The maps created by users can be downloaded as KML file and can be viewed or modified via the freeware application Google Earth or free and open source GIS software like Quantum GIS. The web application is free and available at www.ricercaforestale.it.

  18. RNA-seq analysis of oil palm under cold stress reveals a different C-repeat binding factor (CBF) mediated gene expression pattern in Elaeis guineensis compared to other species.

    Science.gov (United States)

    Lei, Xintao; Xiao, Yong; Xia, Wei; Mason, Annaliese S; Yang, Yaodong; Ma, Zilong; Peng, Ming

    2014-01-01

    Elaeis guineensis as a tropical oil-crop is particularly sensitive to low temperature. Improvement of cold-tolerance may significantly increase the total cultivation area of this tropical oil-crop worldwide. We sequenced cold-treated and control (untreated) samples of Elaeis guineensis. De novo assembly generated 51,452 unigenes with an average length of 703 bp. Subsequently, these expressed sequences were functionally annotated. In the K category (transcription factors) of COG (Cluster of Orthologous Group) annotation, the largest proportion of genes induced and repressed at least two-fold under cold stress were from the AP2/ERE family, indicating that C-repeat binding factor, (CBFs, members of the AP2/ERE family) may play a central role in cold tolerance in Elaeis guineensis. Subsequently, the CBF-mediated signal transduction pathway was reconstructed based on transcriptome data and the gene expression profile involving the pathway was examined using real-time quantitative RT-PCR (qRT-PCR). CBFs reached maximum transcript level both at medium (4 h) and long period time points (7 days), contrary to the expression pattern of CBFs in Arabidopsis and rice. Moreover, the promoters of downstream Cold Responsive gene (CORs) regulated by CBFs were analyzed. Conservation, mutation and absence of the DRE core motif were detected in the promoters of six CORs. These mutations in DRE motifs suggest that CORs may not be induced via cold stress in Elaeis guineensis.

  19. RNA-seq analysis of oil palm under cold stress reveals a different C-repeat binding factor (CBF mediated gene expression pattern in Elaeis guineensis compared to other species.

    Directory of Open Access Journals (Sweden)

    Xintao Lei

    Full Text Available Elaeis guineensis as a tropical oil-crop is particularly sensitive to low temperature. Improvement of cold-tolerance may significantly increase the total cultivation area of this tropical oil-crop worldwide. We sequenced cold-treated and control (untreated samples of Elaeis guineensis. De novo assembly generated 51,452 unigenes with an average length of 703 bp. Subsequently, these expressed sequences were functionally annotated. In the K category (transcription factors of COG (Cluster of Orthologous Group annotation, the largest proportion of genes induced and repressed at least two-fold under cold stress were from the AP2/ERE family, indicating that C-repeat binding factor, (CBFs, members of the AP2/ERE family may play a central role in cold tolerance in Elaeis guineensis. Subsequently, the CBF-mediated signal transduction pathway was reconstructed based on transcriptome data and the gene expression profile involving the pathway was examined using real-time quantitative RT-PCR (qRT-PCR. CBFs reached maximum transcript level both at medium (4 h and long period time points (7 days, contrary to the expression pattern of CBFs in Arabidopsis and rice. Moreover, the promoters of downstream Cold Responsive gene (CORs regulated by CBFs were analyzed. Conservation, mutation and absence of the DRE core motif were detected in the promoters of six CORs. These mutations in DRE motifs suggest that CORs may not be induced via cold stress in Elaeis guineensis.

  20. RNA-seq analysis of oil palm under cold stress reveals a different C-repeat binding factor (CBF) mediated gene expression pattern in Elaeis guineensis compared to other species.

    Science.gov (United States)

    Lei, Xintao; Xiao, Yong; Xia, Wei; Mason, Annaliese S; Yang, Yaodong; Ma, Zilong; Peng, Ming

    2014-01-01

    Elaeis guineensis as a tropical oil-crop is particularly sensitive to low temperature. Improvement of cold-tolerance may significantly increase the total cultivation area of this tropical oil-crop worldwide. We sequenced cold-treated and control (untreated) samples of Elaeis guineensis. De novo assembly generated 51,452 unigenes with an average length of 703 bp. Subsequently, these expressed sequences were functionally annotated. In the K category (transcription factors) of COG (Cluster of Orthologous Group) annotation, the largest proportion of genes induced and repressed at least two-fold under cold stress were from the AP2/ERE family, indicating that C-repeat binding factor, (CBFs, members of the AP2/ERE family) may play a central role in cold tolerance in Elaeis guineensis. Subsequently, the CBF-mediated signal transduction pathway was reconstructed based on transcriptome data and the gene expression profile involving the pathway was examined using real-time quantitative RT-PCR (qRT-PCR). CBFs reached maximum transcript level both at medium (4 h) and long period time points (7 days), contrary to the expression pattern of CBFs in Arabidopsis and rice. Moreover, the promoters of downstream Cold Responsive gene (CORs) regulated by CBFs were analyzed. Conservation, mutation and absence of the DRE core motif were detected in the promoters of six CORs. These mutations in DRE motifs suggest that CORs may not be induced via cold stress in Elaeis guineensis. PMID:25479236

  1. Pharmacogenomics: mapping monogenic mutations to direct therapy

    OpenAIRE

    Taylor, Palmer

    2012-01-01

    The molecular mapping of mutations that underlie congenital disorders of monogenic origin can result in both a broader understanding of the molecular basis of the disorder and novel therapeutic insights. Indeed, genotyping patients and then replicating the behavior of the mutant gene products in well-defined biochemical or electrophysiological systems will allow tailoring of therapy to be mutation- and protein sequence–dependent. In this issue of the JCI, Shen and colleagues describe such an ...

  2. Understanding Spatial Genome Organization: Methods and Insights.

    Science.gov (United States)

    Ramani, Vijay; Shendure, Jay; Duan, Zhijun

    2016-02-01

    The manner by which eukaryotic genomes are packaged into nuclei while maintaining crucial nuclear functions remains one of the fundamental mysteries in biology. Over the last ten years, we have witnessed rapid advances in both microscopic and nucleic acid-based approaches to map genome architecture, and the application of these approaches to the dissection of higher-order chromosomal structures has yielded much new information. It is becoming increasingly clear, for example, that interphase chromosomes form stable, multilevel hierarchical structures. Among them, self-associating domains like so-called topologically associating domains (TADs) appear to be building blocks for large-scale genomic organization. This review describes features of these broadly-defined hierarchical structures, insights into the mechanisms underlying their formation, our current understanding of how interactions in the nuclear space are linked to gene regulation, and important future directions for the field. PMID:26876719

  3. Understanding Spatial Genome Organization: Methods and Insights

    Directory of Open Access Journals (Sweden)

    Vijay Ramani

    2016-02-01

    Full Text Available The manner by which eukaryotic genomes are packaged into nuclei while maintaining crucial nuclear functions remains one of the fundamental mysteries in biology. Over the last ten years, we have witnessed rapid advances in both microscopic and nucleic acid-based approaches to map genome architecture, and the application of these approaches to the dissection of higher-order chromosomal structures has yielded much new information. It is becoming increasingly clear, for example, that interphase chromosomes form stable, multilevel hierarchical structures. Among them, self-associating domains like so-called topologically associating domains (TADs appear to be building blocks for large-scale genomic organization. This review describes features of these broadly-defined hierarchical structures, insights into the mechanisms underlying their formation, our current understanding of how interactions in the nuclear space are linked to gene regulation, and important future directions for the field.

  4. Systemic sclerosis: Recent insights.

    Science.gov (United States)

    Elhai, Muriel; Avouac, Jérôme; Kahan, André; Allanore, Yannick

    2015-05-01

    Systemic sclerosis is an orphan connective tissue disease characterized by alterations of the microvasculature, disturbances of the immune system and massive deposition of collagen and other matrix substances in the skin and internal organs. A major achievement of the recent years has been the validation of new classification criteria, allowing earlier diagnosis and earlier treatment of systemic sclerosis, before irreversible fibrosis and organ damage appeared ("window of opportunity"). Raynaud's phenomenon is usually the first sign of the disease and is considered as the main sentinel sign for the identification of very early systemic sclerosis. Systemic sclerosis is clinically heterogeneous and disease course remains unpredictable. Its prognosis depends on cardiopulmonary involvement and recent studies aim to identify serum or genetic biomarkers predictive of severe organ involvement. Moreover, the prospective follow-up of large cohorts has provided and will offer critical material to identify strong prognostic factors. Whereas the outcomes of vascular manifestations of the disease has been recently improved due to targeted therapy, recent data have highlighted that mortality has not changed over the past 40 years. This reflects the absence of efficacy of current available drugs to counteract the fibrotic process. Nevertheless, several targeted immunity therapies, commonly with proven efficacy in other immune diseases, are about to be investigated in systemic sclerosis. Indeed, promising results in small and open studies have been reported. This article deals with recent insights into classification criteria, pathogenesis, organ involvements, outcome and current and possible future therapeutic options in systemic sclerosis.

  5. Grigor Narekatsi's astronomical insights

    Science.gov (United States)

    Poghosyan, Samvel

    2015-07-01

    What stand out in the solid system of Gr. Narekatsi's naturalistic views are his astronomical insights on the material nature of light, its high speed and the Sun being composed of "material air". Especially surprising and fascinating are his views on stars and their clusters. What astronomers, including great Armenian academician V. Ambartsumian (scattering of stellar associations), would understand and prove with much difficulty thousand years later, Narekatsi predicted in the 10th century: "Stars appear and disappear untimely", "You who gather and scatter the speechless constellations, like a flock of sheep". Gr. Narekatsti's reformative views were manifested in all the spheres of the 10th century social life; he is a reformer of church life, great language constructor, innovator in literature and music, freethinker in philosophy and science. His ideology is the reflection of the 10th century Armenian Renaissance. During the 9th-10th centuries, great masses of Armenians, forced to migrate to the Balkans, took with them and spread reformative ideas. The forefather of the western science, which originated in the period of Reformation, is considered to be the great philosopher Nicholas of Cusa. The study of Gr. Narekatsti's logic and naturalistic views enables us to claim that Gr. Narekatsti is the great grandfather of European science.

  6. O insight em psiquiatria

    Directory of Open Access Journals (Sweden)

    Ana Margarida P. Cardoso

    2008-12-01

    Full Text Available O sinal de que algo está a acontecer contribui para que o paciente reconheça que alguma coisa de estranho se está a passar consigo. Este reconhecimento faz com que o sujeito possa desempenhar uma função activa e seja um elemento colaborante do seu processo de recuperação. Cada doença apresenta, contudo, diferentes sintomas, uma vez que cada doença psiquiátrica consiste em diferentes perturbações com diversos efeitos sobre o funcionamento mental. Desta maneira, o fenómeno do insight que é registado em cada doença é diferente e expressa-se sob diferentes formas, não somente devido às manifestações clínicas da doença mas também devido às características individuais do sujeito.

  7. Mapping the Heart

    Science.gov (United States)

    Hulse, Grace

    2012-01-01

    In this article, the author describes how her fourth graders made ceramic heart maps. The impetus for this project came from reading "My Map Book" by Sara Fanelli. This book is a collection of quirky, hand-drawn and collaged maps that diagram a child's world. There are maps of her stomach, her day, her family, and her heart, among others. The…

  8. USGS Map Indices Overlay Map Service from The National Map

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The USGS Map Indices service from The National Map (TNM) consists of 1x1 Degree, 30x60 Minute (100K), 15 Minute (63K), 7.5 Minute (24K), and 3.75 Minute grid...

  9. -Deformed nonlinear maps

    Indian Academy of Sciences (India)

    Ramaswamy Jaganathan; Sudeshna Sinha

    2005-03-01

    Motivated by studies on -deformed physical systems related to quantum group structures, and by the elements of Tsallis statistical mechanics, the concept of -deformed nonlinear maps is introduced. As a specific example, a -deformation procedure is applied to the logistic map. Compared to the canonical logistic map, the resulting family of -logistic maps is shown to have a wider spectrum of interesting behaviours, including the co-existence of attractors – a phenomenon rare in one-dimensional maps.

  10. VEGETATION MAPPING IN WETLANDS

    Directory of Open Access Journals (Sweden)

    F. PEDROTTI

    2004-01-01

    Full Text Available The current work examines the main aspects of wetland vegetation mapping, which can be summarized as analysis of the ecological-vegetational (ecotone gradients; vegetation complexes; relationships between vegetation distribution and geomorphology; vegetation of the hydrographic basin lo which the wetland in question belongs; vegetation monitoring with help of four vegetation maps: phytosociological map of the real and potential vegetation, map of vegetation dynamical tendencies, map of vegetation series.

  11. Map Projection Transitions

    OpenAIRE

    Nedjeljko Frančula; Miljenko Lapaine

    2013-01-01

    Map Projection Transitions is a very successful web application about map projections. The web page (http://www.jasondavies.com/maps/transition) pre­sents a world map with graticule and country borders in the oblique Aitoff projection, with the South Pole. The map is not static, but animated. The South Pole moves toward the bottom and Earth rotates around its poles. The animation lasts five seconds, after which the projection changes and movement continues for five seconds, after which the pr...

  12. Google Maps: You Are Here

    Science.gov (United States)

    Jacobsen, Mikael

    2008-01-01

    Librarians use online mapping services such as Google Maps, MapQuest, Yahoo Maps, and others to check traffic conditions, find local businesses, and provide directions. However, few libraries are using one of Google Maps most outstanding applications, My Maps, for the creation of enhanced and interactive multimedia maps. My Maps is a simple and…

  13. Web Mapping Using Logo on Map

    OpenAIRE

    Ximing Hou; Hao Shi

    2013-01-01

    The newly proposed Logo on Map (LoM) system consists of three modules: picture extraction module (PEM), logo matching module (LMM) and web mapping module (WMM). Since the first two modules were covered in our previous paper, the third module WMM is described here to present a complete LoM system. Current research is focused on geo-location distribution of brands on Google Maps. Pictures taken by ordinary people are extracted using Picture Extraction Module (PEM). The pictures cont...

  14. Web Mapping Using Logo on Map

    Directory of Open Access Journals (Sweden)

    Ximing Hou

    2013-01-01

    Full Text Available The newly proposed Logo on Map (LoM system consists of three modules: picture extraction module(PEM, logo matching module (LMM and web mapping module (WMM. Since the first two modules werecovered in our previous paper, the third module WMM is described here to present a complete LoM system.Current research is focused on geo-location distribution of brands on Google Maps. Pictures taken byordinary people are extracted using Picture Extraction Module (PEM. The pictures containing relevantlogos are obtained via Logo Matching Module (LMM. Brand distributions are overlaid on Google Maps.In this paper, GPS and brands are briefly described, and the implementation of Web Mapping Module(WMM based on Google Maps API is detailed. Then several experiments are carried out on the selectedtop brands. Finally the LMM-pictures are mapped on the Google Maps and the geographical distributionsof the brands are visualised. Brand uniqueness is discussed and conclusion is drawn that with uniquebrand names web mapping can visually reflect the real economic activities of a company in the world.

  15. Web Mapping Using Logo on Map

    Directory of Open Access Journals (Sweden)

    Ximing Hou

    2012-12-01

    Full Text Available The newly proposed Logo on Map (LoM system consists of three modules: picture extraction module (PEM, logo matching module (LMM and web mapping module (WMM. Since the first two modules were covered in our previous paper, the third module WMM is described here to present a complete LoM system. Current research is focused on geo-location distribution of brands on Google Maps. Pictures taken by ordinary people are extracted using Picture Extraction Module (PEM. The pictures containing relevant logos are obtained via Logo Matching Module (LMM. Brand distributions are overlaid on Google Maps. In this paper, GPS and brands are briefly described, and the implementation of Web Mapping Module (WMM based on Google Maps API is detailed. Then several experiments are carried out on the selected top brands. Finally the LMM-pictures are mapped on the Google Maps and the geographical distributions of the brands are visualised. Brand uniqueness is discussed and conclusion is drawn that with unique brand names web mapping can visually reflect the real economic activities of a company in the world.

  16. Recent Neurobiological Insights into the Concept of Insight in Psychosis

    Science.gov (United States)

    Mythri, Starlin Vijay; Sanjay, Y

    2016-01-01

    The concept of insight in psychosis has been an interesting area in clinical psychiatry for well over a century with a surge in research interest over the past 25 years. Moreover, the past 5 years have been particularly fruitful in deciphering its neurobiological underpinnings. This article presents the development of the concept of insight in psychosis and reviews the current neurobiological research findings in this area. PMID:27335512

  17. Deconstructing Insight: EEG Correlates of Insightful Problem Solving

    OpenAIRE

    Simone Sandkühler; Joydeep Bhattacharya

    2008-01-01

    BACKGROUND: Cognitive insight phenomenon lies at the core of numerous discoveries. Behavioral research indicates four salient features of insightful problem solving: (i) mental impasse, followed by (ii) restructuring of the problem representation, which leads to (iii) a deeper understanding of the problem, and finally culminates in (iv) an "Aha!" feeling of suddenness and obviousness of the solution. However, until now no efforts have been made to investigate the neural mechanisms of these co...

  18. Mapping transient hyperventilation induced alterations with estimates of the multi-scale dynamics of BOLD signal.

    Directory of Open Access Journals (Sweden)

    Vesa J Kiviniemi

    2009-07-01

    Full Text Available Temporal blood oxygen level dependent (BOLD contrast signals in functional MRI during rest may be characterized by power spectral distribution (PSD trends of the form 1/f α. Trends with 1/f characteristics comprise fractal properties with repeating oscillation patterns in multiple time scales. Estimates of the fractal properties enable the quantification of phenomena that may otherwise be difficult to measure, such as transient, non-linear changes. In this study it was hypothesized that the fractal metrics of 1/f BOLD signal trends can map changes related to dynamic, multi-scale alterations in cerebral blood flow (CBF after a transient hyperventilation challenge. Twenty-three normal adults were imaged in a resting-state before and after hyperventilation. Different variables (1/f trend constant α, fractal dimension Df, and, Hurst exponent H characterizing the trends were measured from BOLD signals. The results show that fractal metrics of the BOLD signal follow the fractional Gaussian noise model, even during the dynamic CBF change that follows hyperventilation. The most dominant effect on the fractal metrics was detected in grey matter, in line with previous hyperventilation vaso-reactivity studies. The α was able to differentiate also blood vessels from grey matter changes. Df was most sensitive to grey matter. H correlated with default mode network areas before hyperventilation but this pattern vanished after hyperventilation due to a global increase in H. In the future, resting-state fMRI combined with fractal metrics of the BOLD signal may be used for analyzing multi-scale alterations of cerebral blood flow.

  19. Multivalued Mappings and Applications

    Directory of Open Access Journals (Sweden)

    Jingling Zhang

    2012-01-01

    nonexpansive multi-valued mapping and to prove the strong convergence theorems of fixed point for weak relatively nonexpansive multivalued mappings in Banach spaces. The weak relatively nonexpansive multivalued mappings are more generalized than relatively nonexpansive multivalued mappings. In this paper, an example will be given which is a weak relatively nonexpansive multivalued mapping but not a relatively nonexpansive multivalued mapping. In order to get the strong convergence theorems for weak relatively nonexpansive multivalued mappings, a new monotone hybrid iteration algorithm with generalized (metric projection is presented and is used to approximate the fixed point of weak relatively nonexpansive multivalued mappings. In this paper, the notion of multivalued resolvent of maximal monotone operator has been also presented which is a weak relatively nonexpansive multivalued mapping and can be used to find the zero point of maximal monotone operator.

  20. Mind maps in service of the mental brain activity

    OpenAIRE

    JOSIPOVIĆ JELIĆ, ŽELJKA; Demarin, Vida; Šoljan, Ivana

    2014-01-01

    Tony Buzan is the creator of the mind maps who based his mnemonic techniques of brain mapping on the terms of awareness and wide brain functionality as well as on the ability of memorizing, reading and creativity. He conceived the idea that regular practice improves brain functions but he also introduced radiant thinking and mental literacy. One of the last enormous neuroscience ventures is to clarify the brain complexity and mind and to get a complete insight into the mental brain acti...

  1. Interpreting maps through the eyes of expert and novice users

    OpenAIRE

    Ooms, Kristien; De Maeyer, Philippe; Fack, Veerle; Van Assche, Eva; Witlox, Frank

    2012-01-01

    The experiments described in this article combine response time measurements and eye movement data to gain insight into the users' cognitive processes while working with dynamic and interactive maps. Experts and novices participated in a user study with a 'between user' design. Twenty screen maps were presented in a random order to each participant, on which he had to execute a visual search. The combined information of the button actions and eye tracker reveals that both user groups showed a...

  2. MaNGA: Mapping Nearby Galaxies at Apache Point Observatory

    CERN Document Server

    Weijmans, Anne-Marie

    2015-01-01

    MaNGA (Mapping Nearby Galaxies at APO) is a galaxy integral-field spectroscopic survey within the fourth generation Sloan Digital Sky Survey (SDSS-IV). It will be mapping the composition and kinematics of gas and stars in 10,000 nearby galaxies, using 17 differently sized fiber bundles. MaNGA's goal is to provide new insights in galaxy formation and evolution, and to deliver a local benchmark for current and future high-redshift studies.

  3. MaNGA: Mapping Nearby Galaxies at Apache Point Observatory

    Science.gov (United States)

    Weijmans, A.-M.; MaNGA Team

    2016-10-01

    MaNGA (Mapping Nearby Galaxies at APO) is a galaxy integral-field spectroscopic survey within the fourth generation Sloan Digital Sky Survey (SDSS-IV). It will be mapping the composition and kinematics of gas and stars in 10,000 nearby galaxies, using 17 differently sized fiber bundles. MaNGA's goal is to provide new insights in galaxy formation and evolution, and to deliver a local benchmark for current and future high-redshift studies.

  4. Prospective long-term minimal residual disease monitoring using RQ-PCR in RUNX1-RUNX1T1-positive acute myeloid leukemia: results of the French CBF-2006 trial.

    Science.gov (United States)

    Willekens, Christophe; Blanchet, Odile; Renneville, Aline; Cornillet-Lefebvre, Pascale; Pautas, Cécile; Guieze, Romain; Ifrah, Norbert; Dombret, Hervé; Jourdan, Eric; Preudhomme, Claude; Boissel, Nicolas

    2016-03-01

    In t(8;21)(q22;q22) acute myeloid leukemia, the prognostic value of early minimal residual disease assessed with real-time quantitative polymerase chain reaction is the most important prognostic factor, but how long-term minimal residual disease monitoring may contribute to drive individual patient decisions remains poorly investigated. In the multicenter CBF-2006 study, a prospective monitoring of peripheral blood and bone marrow samples was performed every 3 months and every year, respectively, for 2 years following intensive chemotherapy in 94 patients in first complete remission. A complete molecular remission was defined as a (RUNX1-RUNX1T1/ABL1)×100 ≤ 0.001%. After the completion of consolidation therapy, a bone marrow complete molecular remission was observed in 30% of the patients, but was not predictive of subsequent relapse. Indeed, 8 patients (9%) presented a positive bone marrow minimal residual disease for up to 2 years of follow-up while still remaining in complete remission. Conversely, a peripheral blood complete molecular remission was statistically associated with a lower risk of relapse whatever the time-point considered after the completion of consolidation therapy. During the 2-year follow-up, the persistence of peripheral blood complete molecular remission was associated with a lower risk of relapse (4-year cumulative incidence, 8.2%), while molecular relapse confirmed on a subsequent peripheral blood sample predicted hematological relapse (4-year cumulative incidence, 86.9%) within a median time interval of 3.9 months. In t(8;21)(q22;q22) acute myeloid leukemia, minimal residual disease monitoring on peripheral blood every 3 months allows for the prediction of hematological relapse, and to identify patients who could potentially benefit from intervention therapy. (ClinicalTrials.gov ID #NCT00428558). PMID:26635039

  5. The Box H/ACA snoRNP Assembly Factor Shq1p is a Chaperone Protein Homologous to Hsp90 Cochaperones that Binds to the Cbf5p Enzyme

    Energy Technology Data Exchange (ETDEWEB)

    Godin, Katherine S.; Walbott, Helene; Leulliot, Nicolas; van Tilbeurgh, Herman; Varani, Gabriele

    2009-05-06

    Box H/ACA small nucleolar (sno) ribonucleoproteins (RNPs) are responsible for the formation of pseudouridine in a variety of RNAs and are essential for ribosome biogenesis, modification of spliceosomal RNAs, and telomerase stability. A mature snoRNP has been reconstituted in vitro and is composed of a single RNA and four proteins. However, snoRNP biogenesis in vivo requires multiple factors to coordinate a complex and poorly understood assembly and maturation process. Among the factors required for snoRNP biogenesis in yeast is Shq1p, an essential protein necessary for stable expression of box H/ACA snoRNAs. We have found that Shq1p consists of two independent domains that contain casein kinase 1 phosphorylation sites. We also demonstrate that Shq1p binds the pseudourydilating enzyme Cbf5p through the C-terminal domain, in synergy with the N-terminal domain. The NMR solution structure of the N-terminal domain has striking homology to the ‘Chord and Sgt1’ domain of known Hsp90 cochaperones, yet Shq1p does not interact with the yeast Hsp90 homologue in vitro. Surprisingly, Shq1p has stand-alone chaperone activity in vitro. This activity is harbored by the C-terminal domain, but it is increased by the presence of the N-terminal domain. These results provide the first evidence of a specific biochemical activity for Shq1p and a direct link to the H/ACA snoRNP.

  6. Edge maps: Representing flow with bounded error

    KAUST Repository

    Bhatia, Harsh

    2011-03-01

    Robust analysis of vector fields has been established as an important tool for deriving insights from the complex systems these fields model. Many analysis techniques rely on computing streamlines, a task often hampered by numerical instabilities. Approaches that ignore the resulting errors can lead to inconsistencies that may produce unreliable visualizations and ultimately prevent in-depth analysis. We propose a new representation for vector fields on surfaces that replaces numerical integration through triangles with linear maps defined on its boundary. This representation, called edge maps, is equivalent to computing all possible streamlines at a user defined error threshold. In spite of this error, all the streamlines computed using edge maps will be pairwise disjoint. Furthermore, our representation stores the error explicitly, and thus can be used to produce more informative visualizations. Given a piecewise-linear interpolated vector field, a recent result [15] shows that there are only 23 possible map classes for a triangle, permitting a concise description of flow behaviors. This work describes the details of computing edge maps, provides techniques to quantify and refine edge map error, and gives qualitative and visual comparisons to more traditional techniques. © 2011 IEEE.

  7. Mapping Mutations on Phylogenies

    DEFF Research Database (Denmark)

    Nielsen, Rasmus

    2005-01-01

    This chapter provides a short review of recent methodologies developed for mapping mutations on phylogenies. Mapping of mutations, or character changes in general, using the maximum parsimony principle has been one of the most powerful tools in phylogenetics, and it has been used in a variety of ...... uncertainty in the mapping. Recently developed probabilistic methods can incorporate statistical uncertainty in the character mappings. In these methods, focus is on a probability distribution of mutational mappings instead of a single estimate of the mutational mapping....

  8. Mapping with Drupal

    CERN Document Server

    Palazzolo, Alan

    2011-01-01

    Build beautiful interactive maps on your Drupal website, and tell engaging visual stories with your data. This concise guide shows you how to create custom geographical maps from top to bottom, using Drupal 7 tools and out-of-the-box modules. You'll learn how mapping works in Drupal, with examples on how to use intuitive interfaces to map local events, businesses, groups, and other custom data. Although building maps with Drupal can be tricky, this book helps you navigate the system's complexities for creating sophisticated maps that match your site design. Get the knowledge and tools you ne

  9. Some Semi - Equivelar Maps

    CERN Document Server

    Upadhyay, Ashish K; Maity, Dipendu

    2011-01-01

    Semi-Equivelar maps are generalizations of Archimedean Solids (as are equivelar maps of the Platonic solids) to the surfaces other than $2-$Sphere. We classify some semi equivelar maps on surface of Euler characteristic -1 and show that none of these are vertex transitive. We establish existence of 12-covered triangulations for this surface. We further construct double cover of these maps to show existence of semi-equivelar maps on the surface of double torus. We also construct several semi-equivelar maps on the surfaces of Euler characteristics -8 and -10 and on non-orientable surface of Euler characteristics -2.

  10. Mapping in the cloud

    CERN Document Server

    Peterson, Michael P

    2014-01-01

    This engaging text provides a solid introduction to mapmaking in the era of cloud computing. It takes students through both the concepts and technology of modern cartography, geographic information systems (GIS), and Web-based mapping. Conceptual chapters delve into the meaning of maps and how they are developed, covering such topics as map layers, GIS tools, mobile mapping, and map animation. Methods chapters take a learn-by-doing approach to help students master application programming interfaces and build other technical skills for creating maps and making them available on the Internet. Th

  11. Active Fire Mapping Program

    Science.gov (United States)

    Active Fire Mapping Program Current Large Incidents (Home) New Large Incidents Fire Detection Maps MODIS Satellite Imagery VIIRS Satellite Imagery Fire Detection GIS Data Fire Data in Google Earth ...

  12. NAIP Status Maps Gallery

    Data.gov (United States)

    Farm Service Agency, Department of Agriculture — NAIP Status Maps Gallery. These maps illustrate what aerial imagery collection is planned, whats been collected, when it is available and how it is available. These...

  13. MapBook

    Data.gov (United States)

    National Aeronautics and Space Administration — Beginning with the systematic mapping of the lunar surface more than three decades ago, this database contains over 1600 maps of the planets and satellites of the...

  14. Recovery Action Mapping Tool

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Recovery Action Mapping Tool is a web map that allows users to visually interact with and query actions that were developed to recover species listed under the...

  15. Invariants for Parallel Mapping

    Institute of Scientific and Technical Information of China (English)

    YIN Yajun; WU Jiye; FAN Qinshan; HUANG Kezhi

    2009-01-01

    This paper analyzes the geometric quantities that remain unchanged during parallel mapping (i.e., mapping from a reference curved surface to a parallel surface with identical normal direction). The second gradient operator, the second class of integral theorems, the Gauss-curvature-based integral theorems, and the core property of parallel mapping are used to derive a series of parallel mapping invadants or geometri-cally conserved quantities. These include not only local mapping invadants but also global mapping invari-ants found to exist both in a curved surface and along curves on the curved surface. The parallel mapping invadants are used to identify important transformations between the reference surface and parallel surfaces. These mapping invadants and transformations have potential applications in geometry, physics, biome-chanics, and mechanics in which various dynamic processes occur along or between parallel surfaces.

  16. Mapping Medicare Disparities Tool

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CMS Office of Minority Health has designed an interactive map, the Mapping Medicare Disparities Tool, to identify areas of disparities between subgroups of...

  17. Letter of Map Revision

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — The National Flood Hazard Layer (NFHL) data incorporates all Digital Flood Insurance Rate Map(DFIRM) databases published by FEMA, and any Letters Of Map Revision...

  18. NGS Survey Control Map

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NGS Survey Control Map provides a map of the US which allows you to find and display geodetic survey control points stored in the database of the National...

  19. Branched polynomial covering maps

    DEFF Research Database (Denmark)

    Hansen, Vagn Lundsgaard

    2002-01-01

    A Weierstrass polynomial with multiple roots in certain points leads to a branched covering map. With this as the guiding example, we formally define and study the notion of a branched polynomial covering map. We shall prove that many finite covering maps are polynomial outside a discrete branch...... set. Particular studies are made of branched polynomial covering maps arising from Riemann surfaces and from knots in the 3-sphere. (C) 2001 Elsevier Science B.V. All rights reserved....

  20. Diffusion Based Photon Mapping

    DEFF Research Database (Denmark)

    Schjøth, Lars; Fogh Olsen, Ole; Sporring, Jon

    2007-01-01

    . To address this problem we introduce a novel photon mapping algorithm based on nonlinear anisotropic diffusion. Our algorithm adapts according to the structure of the photon map such that smoothing occurs along edges and structures and not across. In this way we preserve the important illumination features......, while eliminating noise. We call our method diffusion based photon mapping....

  1. Reading Angles in Maps

    Science.gov (United States)

    Izard, Véronique; O'Donnell, Evan; Spelke, Elizabeth S.

    2014-01-01

    Preschool children can navigate by simple geometric maps of the environment, but the nature of the geometric relations they use in map reading remains unclear. Here, children were tested specifically on their sensitivity to angle. Forty-eight children (age 47:15-53:30 months) were presented with fragments of geometric maps, in which angle sections…

  2. Deconstructing insight: EEG correlates of insightful problem solving.

    Directory of Open Access Journals (Sweden)

    Simone Sandkühler

    Full Text Available BACKGROUND: Cognitive insight phenomenon lies at the core of numerous discoveries. Behavioral research indicates four salient features of insightful problem solving: (i mental impasse, followed by (ii restructuring of the problem representation, which leads to (iii a deeper understanding of the problem, and finally culminates in (iv an "Aha!" feeling of suddenness and obviousness of the solution. However, until now no efforts have been made to investigate the neural mechanisms of these constituent features of insight in a unified framework. METHODOLOGY/PRINCIPAL FINDINGS: In an electroencephalographic study using verbal remote associate problems, we identified neural correlates of these four features of insightful problem solving. Hints were provided for unsolved problems or after mental impasse. Subjective ratings of the restructuring process and the feeling of suddenness were obtained on trial-by-trial basis. A negative correlation was found between these two ratings indicating that sudden insightful solutions, where restructuring is a key feature, involve automatic, subconscious recombination of information. Electroencephalogram signals were analyzed in the space x time x frequency domain with a nonparametric cluster randomization test. First, we found strong gamma band responses at parieto-occipital regions which we interpreted as (i an adjustment of selective attention (leading to a mental impasse or to a correct solution depending on the gamma band power level and (ii encoding and retrieval processes for the emergence of spontaneous new solutions. Secondly, we observed an increased upper alpha band response in right temporal regions (suggesting active suppression of weakly activated solution relevant information for initially unsuccessful trials that after hint presentation led to a correct solution. Finally, for trials with high restructuring, decreased alpha power (suggesting greater cortical excitation was observed in right prefrontal

  3. Mapping the Constellation of Educational Marxism(s)

    Science.gov (United States)

    Lewis, Tyson E.

    2012-01-01

    In this paper, the author maps three radically different visions of Marxism in educational philosophy. Each "register" contains insights but also contradictions that cannot easily be resolved through internal modifications of the theory or through theoretical synthesis with other registers. The radical function of Marxist pedagogy is to create a…

  4. Thematic Maps for Humanitarian Demining

    Directory of Open Access Journals (Sweden)

    Andrija Krtalić

    2012-05-01

    Full Text Available The Croatian Mine Action Centre (CROMAC reviewed, defined and marked the entire mine suspected area (MSA in Croatia by the year 2004. However, due to the need to reduce risk and the lack of information from the deepest reaches of the MSA, its surface area was defined as larger than in reality. Mine clearance is a long-term, expensive process, and Croatia has committed itself to resolving the problem of landmines on its territory by 201 9. Such developments have led to searching for and finding solutions to speed up resolution of the mine problem in Croatia (and in the world through reducing the defined MSA. The reduction of an already defined MSA requires additional data and information from the deepest reaches of the MSA, on the basis of which a revision of existing SMEs to make reductions will be carried out. Based on these data and revision of the existing MSA, reduction can be performed. All subsequently collected data and information, together with previously known data from the CROMAC Mine Information System (MIS, are processed in the decision support system in conditions of uncertainty. The results obtained are displayed on different thematic maps, showing the positions of objects and their spatial impact on the environment. Thus, thematic maps allow insights into topics which experts in humanitarian demining can use to make decisions in the process. These thematic maps are the result of the methodology created within the project Space and Airborne Mined Area Reduction Tools (SMART, and further developed in the technological project System for Multisensor Airborne Reconnaissance and Surveillance in Emergency Situations and Environmental Protection, TP-06/0007-01 , Ministry of Science, Education and Sports; Deployment of Advanced Intelligence Decision Support System for Mine Suspected Area Reduction in Bosnia and Herzegovina and the author's doctoral dissertation. This paper establishes the new terminology for new, improved thematic maps

  5. OpenStreetMap, the Wikipedia Map

    Directory of Open Access Journals (Sweden)

    Gunther Maier

    2014-12-01

    Full Text Available This paper presents OpenStreetMap and closely related software as a resource for spatial economic research. The paper demonstrates how information can be extracted from OpenStreetMap, how it can be used as a geographical interface in web-based communication, and illustrates the value of the tools by use of a specific application, the WU campus GIS.

  6. Cosmopolitan linkage disequilibrium maps

    Directory of Open Access Journals (Sweden)

    Gibson Jane

    2005-03-01

    Full Text Available Abstract Linkage maps have been invaluable for the positional cloning of many genes involved in severe human diseases. Standard genetic linkage maps have been constructed for this purpose from the Centre d'Etude du Polymorphisme Humain and other panels, and have been widely used. Now that attention has shifted towards identifying genes predisposing to common disorders using linkage disequilibrium (LD and maps of single nucleotide polymorphisms (SNPs, it is of interest to consider a standard LD map which is somewhat analogous to the corresponding map for linkage. We have constructed and evaluated a cosmopolitan LD map by combining samples from a small number of populations using published data from a 10-megabase region on chromosome 20. In support of a pilot study, which examined a number of small genomic regions with a lower density of markers, we have found that a cosmopolitan map, which serves all populations when appropriately scaled, recovers 91 to 95 per cent of the information within population-specific maps. Recombination hot spots appear to have a dominant role in shaping patterns of LD. The success of the cosmopolitan map might be attributed to the co-localisation of hot spots in all populations. Although there must be finer scale differences between populations due to other processes (mutation, drift, selection, the results suggest that a whole-genome standard LD map would indeed be a useful resource for disease gene mapping.

  7. Understanding Insight in the Context of Q

    Science.gov (United States)

    Coghlan, David

    2012-01-01

    In Revans' learning formula, L = P + Q, Q represents "questioning insight", by which Revans means that insight comes out of the process of questioning programmed knowledge (P) in the light of experience. We typically focus on the content of an insight rather than on the act of insight. Drawing primarily on the work of Bernard Lonergan this paper…

  8. Chemical Mapping of Vesta

    Science.gov (United States)

    Prettyman, Thomas H.; Mittlefehldt, D. W.; Yamashita, N.; Lawrence, D. J.; Beck, A. W.; McSween, H. Y.; Feldman, W. C.; McCoy, T. J.; Titus, T. N.; Toplis, M. J.; Reedy, R. C.; Forni, O.; Mizzon, H.; Peplowski, P. N.; Raymond, C. A.; Russell, C. T.

    2012-01-01

    Vesta s surface mineralogy and composition have been studied for decades via telescopic spectroscopy and laboratory analyses of the howardite, eucrite, and diogenite (HED) meteorites, which are thought to originate from Vesta. Visible and infrared reflectance measurements by Dawn have broadly confirmed the paradigm established by Earth-based work, strengthening the Vesta-HED connection. The Dawn mission has achieved a milestone by completing the first chemical measurements of a main-belt asteroid using nuclear spectroscopy. Dawn s Gamma Ray and Neutron Detector (GRaND) has globally mapped the composition of Vesta, including the portions of the northern hemisphere not illuminated by solar radiation. GRaND is sensitive to the composition of the bulk regolith to depths of several decimeters. Abundances and/or detection limits for specific elements and elemental ratios, such as H, Fe, Si, Fe/O, Fe/Si, and K, have been measured. Variations in the average atomic mass and neutron macroscopic absorption cross section have been characterized. The measurements constrain the relative proportions of HED whole-rock end-members, providing measurements of the pyroxene and plagioclase content of the regolith, thereby constraining the processes underlying Vesta s differentiation and crustal evolution. The spatial resolution of GRaND is sufficient to determine basin-average compositions of Veneneia and Rheasilvia, which may contain outcrops of Vesta s olivine-rich mantle. While the elemental composition of Vesta s regolith is similar to the meteorites, there are notable departures from HED whole-rock compositions. While these differences are not sufficient to topple the Vesta-HED paradigm, they provide insight into global-scale processes that have shaped Vesta s surface. Questions addressed by the analysis of GRaND data include: (i) Is Vesta the source of the Fe-rich mesosiderites? (ii) Are evolved, igneous lithologies present on Vesta s surface? (iii) What are the origins of

  9. Exploiting Surroundedness for Saliency Detection: A Boolean Map Approach.

    Science.gov (United States)

    Zhang, Jianming; Sclaroff, Stan

    2016-05-01

    We demonstrate the usefulness of surroundedness for eye fixation prediction by proposing a Boolean Map based Saliency model (BMS). In our formulation, an image is characterized by a set of binary images, which are generated by randomly thresholding the image's feature maps in a whitened feature space. Based on a Gestalt principle of figure-ground segregation, BMS computes a saliency map by discovering surrounded regions via topological analysis of Boolean maps. Furthermore, we draw a connection between BMS and the Minimum Barrier Distance to provide insight into why and how BMS can properly captures the surroundedness cue via Boolean maps. The strength of BMS is verified by its simplicity, efficiency and superior performance compared with 10 state-of-the-art methods on seven eye tracking benchmark datasets.

  10. A dense genetic linkage map for common carp and its integration with a BAC-based physical map.

    Directory of Open Access Journals (Sweden)

    Lan Zhao

    Full Text Available BACKGROUND: Common carp (Cyprinus carpio is one of the most important aquaculture species with an annual global production of 3.4 million metric tons. It is also an important ornamental species as well as an important model species for aquaculture research. To improve the economically important traits of this fish, a number of genomic resources and genetic tools have been developed, including several genetic maps and a bacterial artificial chromosome (BAC-based physical map. However, integrated genetic and physical maps are not available to study quantitative trait loci (QTL and assist with fine mapping, positional cloning and whole genome sequencing and assembly. The objective of this study was to integrate the currently available BAC-based physical and genetic maps. RESULTS: The genetic map was updated with 592 novel markers, including 312 BAC-anchored microsatellites and 130 SNP markers, and contained 1,209 genetic markers on 50 linkage groups, spanning 3,565.9 cM in the common carp genome. An integrated genetic and physical map of the common carp genome was then constructed, which was composed of 463 physical map contigs and 88 single BACs. Combined lengths of the contigs and single BACs covered a physical length of 498.75 Mb, or around 30% of the common carp genome. Comparative analysis between common carp and zebrafish genomes was performed based on the integrated map, providing more insights into the common carp specific whole genome duplication and segmental rearrangements in the genome. CONCLUSION: We integrated a BAC-based physical map to a genetic linkage map of common carp by anchoring BAC-associated genetic markers. The density of the genetic linkage map was significantly increased. The integrated map provides a tool for both genetic and genomic studies of common carp, which will help us to understand the genomic architecture of common carp and facilitate fine mapping and positional cloning of economically important traits for

  11. $2^n-$rational maps

    OpenAIRE

    Kassotakis, Pavlos; Nieszporski, Maciej; Damianou, Pantelis

    2015-01-01

    We present a natural extension of the notion of nondegenerate rational maps (quadrirational maps) to arbitrary dimensions. We refer to these maps as $2^n-$rational maps. In this note we construct a rich family of $2^n-$rational maps. These maps by construction are involutions and highly symmetric in the sense that the maps and their companion maps have the same functional form.

  12. Failures of metacognition and lack of insight in neuropsychiatric disorders.

    Science.gov (United States)

    David, Anthony S; Bedford, Nicholas; Wiffen, Ben; Gilleen, James

    2012-05-19

    Lack of insight or unawareness of illness are the hallmarks of many psychiatric disorders, especially schizophrenia (SCZ) and other psychoses and could be conceived of as a failure in metacognition. Research in this area in the mental health field h as burgeoned with the development and widespread use of standard assessment instruments and the mapping out of the clinical and neuropsychological correlates of insight and its loss. There has been a growing appreciation of the multi-faceted nature of the concept and of the different 'objects' of insight, such as the general awareness that one is ill, to more specific metacognitive awareness of individual symptoms, impairments and performance. This in turn has led to the notion that insight may show modularity and may fractionate across different domains and disorders, supported by work that directly compares metacognition of memory deficits and illness awareness in patients with SCZ, Alzheimer's disease and brain injury. The focus of this paper will be on the varieties of metacognitive failure in psychiatry, particularly the psychoses. We explore cognitive models based on self-reflectiveness and their possible social and neurological bases, including data from structural and functional MRI. The medial frontal cortex appears to play an important role in self-appraisal in health and disease.

  13. 核心结合因子α1在BMP-2调控细胞外基质蛋白表达中的作用%Study of cbfα1 on the expression of extracellular matrix proteins in dental papilla cells induced by BMP-2 in vitro

    Institute of Scientific and Technical Information of China (English)

    余擎; 朱庆林; 孙汉堂; 田宇; 何文喜; 肖明振

    2008-01-01

    目的:探讨核心结合因子α1(cbfa1)在BMP-2调控体外培养的牙乳头细胞表达细胞外基质蛋白中的作用.方法:采用反义核酸技术,体外阻断培养的牙乳头细胞中cbfα1的表达,分别用RT-PCR、Western印迹等方法观察200ng/mL BMP-2作用6h后细胞中相关基质蛋白,碱性磷酸酶(ALP)、骨钙素(OC)、骨连蛋白(ON)、骨桥素(OPN)、骨涎蛋白(BSP)、牙本质基质蛋白1(DMP-1)以及牙本质涎磷蛋白(DSPP)的表达,采用SPSS 11.0软件包对数据进行方差分析.结果:外源性BMP-2能明显上调牙乳头细胞中ALP、OC含量以及OPN、BSP和ON的表达,当反义阻断cbfα1的表达时,ALP、OC、OPN和BSP的表达显著降低(P<0.01).结论:cbfα1参与了BMP-2调控体外培养的牙乳头细胞表达细胞外基质蛋白的信号转导过程.

  14. High-spatial-resolution mapping of the oxygen concentration in cortical tissue (Conference Presentation)

    Science.gov (United States)

    Jaswal, Rajeshwer S.; Yaseen, Mohammad A.; Fu, Buyin; Boas, David A.; Sakadžic, Sava

    2016-03-01

    Due to a lack of imaging tools for high-resolution imaging of cortical tissue oxygenation, the detailed maps of the oxygen partial pressure (PO2) around arterioles, venules, and capillaries remain largely unknown. Therefore, we have limited knowledge about the mechanisms that secure sufficient oxygen delivery in microvascular domains during brain activation, and provide some metabolic reserve capacity in diseases that affect either microvascular networks or the regulation of cerebral blood flow (CBF). To address this challenge, we applied a Two-Photon PO2 Microscopy to map PO2 at different depths in mice cortices. Measurements were performed through the cranial window in the anesthetized healthy mice as well as in the mouse models of microvascular dysfunctions. In addition, microvascular morphology was recorded by the two-photon microscopy at the end of each experiment and subsequently segmented. Co-registration of the PO2 measurements and exact microvascular morphology enabled quantification of the tissue PO2 dependence on distance from the arterioles, capillaries, and venules at various depths. Our measurements reveal significant spatial heterogeneity of the cortical tissue PO2 distribution that is dominated by the high oxygenation in periarteriolar spaces. In cases of impaired oxygen delivery due to microvascular dysfunction, significant reduction in tissue oxygenation away from the arterioles was observed. These tissue domains may be the initial sites of cortical injury that can further exacerbate the progression of the disease.

  15. MR Perfusion-derived Hemodynamic Parametric Response Mapping of Bevacizumab Efficacy in Recurrent Glioblastoma.

    Science.gov (United States)

    Kickingereder, Philipp; Radbruch, Alexander; Burth, Sina; Wick, Antje; Heiland, Sabine; Schlemmer, Heinz-Peter; Wick, Wolfgang; Bendszus, Martin; Bonekamp, David

    2016-05-01

    Purpose To better understand the effect of bevacizumab therapy on tumor blood flow and oxygenation status in patients with recurrent glioblastoma. Materials and Methods Retrospective data evaluation was approved by the local ethics committee of the University of Heidelberg (ethics approval number, S-320/2012), and informed consent was waived. A total of 71 patients who received a diagnosis of recurrent glioblastoma underwent conventional anatomic magnetic resonance (MR) imaging and dynamic susceptibility contrast material-enhanced MR imaging at baseline and at the first follow-up examination after initiation of bevacizumab therapy. Parametric response maps (PRMs) were created with multistep (nonlinear) registration of patients' post- to pretreatment images and voxel-wise subtraction between Gaussian-normalized relative cerebral blood volume (nrCBV) and Gaussian-normalized relative cerebral blood flow (nrCBF) maps. Intratumor voxels were stratified as being increased (PRM[+]) or decreased (PRM[-]) if they exceeded a threshold that represented the 95% confidence interval in the normal-appearing brain. Correlation with progression-free and overall survival was performed with Cox proportional hazards models. Results The risks for disease progression and death significantly increased with (a) higher baseline nrCBV (hazard ratio [HR] = 1.86, P reversal of the biologic behavior and relative prognosis of these tumors does not occur. (©) RSNA, 2015 Online supplemental material is available for this article. PMID:26579564

  16. IAA和GA3诱导荠菜CBF途径冷应答相关基因表达的研究%A study on the regulation of the expression of cold-responsive genes in CBF signaling pathway from Capsella bursa-pastoric induced by IAA and GA3

    Institute of Scientific and Technical Information of China (English)

    周明琦; 吴丽华; 沈忱; 林娟

    2011-01-01

    Coldness, dehydration and highly-salty condition are the main environmental hazards limiting plant growth.Plants in temperate and cold belts can protect the cells by promoting the particular genes expression through cold induction or cold acclimation.The CBF signaling pathway, which draws much attention recently, has been verified to be the key responder to cold stress in plants.In the present article, the expression patterns of genes in CBF pathway from Capsella bursa-pastoris under IAA and GA3 treatments were analyzed with RT-PCR, representing the difference between the regulatory mechanisms of these two hormones in inductions of gene expression in CBF pathway.It can be concluded that the CBF signaling pathway responds not only to coldness, but also to IAA and GA3.%低温、干早以及高盐条件是植物生长过程中所面临的主要逆境胁迫.植物中的CBF途径已被证实是斌予植物低温抗性的主效途径,近年来备受关注.为了阐明荠菜中CBF途径冷应答相关基因表达与激素诱导之间的相关性,本研究利用RT-PCR技术,对2种激紊分子生长素(IAA)和赤霉素(GA3)诱导处理的荠莱幼苗中CBF途径杭冷相关基因的转录本进行了半定量分析.结果表明,2种激素分子对荠莱CBF途径冷应答相关基因表达诱导作用有一定的差异.因此认为荠莱CBF途径冷应答相关基因表达不仅具有低温的诱导性,而且也具有激素分子IAA和GA,的应答性.这一结果对进一步阐明植物激素在CBF信号途径中的调控作用具有重要意义.

  17. Participatory systems mapping for sustainable consumption

    DEFF Research Database (Denmark)

    Sedlacko, Michal; Martinuzzi, Andre; Røpke, Inge;

    2014-01-01

    The paper describes our usage of and experience with the method of participatory systems mapping. The method, developed for the purpose of facilitating knowledge brokerage, builds on participatory modelling approaches and applications and was used in several events involving both researchers...... and policy makers. The paper presents and discusses examples of how different types of participatory interaction with causal loop diagrams (‘system maps’) produced different insights on issues related to sustainable consumption and enabled participatory reflection and sharing of knowledge. Together......, these insights support a systemic understanding of the issues and Thus the method provides instruments for coping with complexity when formulating policies for sustainable consumption. Furthermore the paper discusses the ability of the method—and its limits—to connect mental models of participants through...

  18. Global China Insights December 2013

    NARCIS (Netherlands)

    Segers, Rien T.; Havinga, Marieke; Fischer, Ingrid

    2013-01-01

    Journal in which the Groningen Confucius Institute (GCI) shares different perspectives on China and provides insights into China from as many different aspects as possible. GCI aims to provide a full view of real China to the readers as well as featuring international and comprehensive perspectives,

  19. Investigating Insight as Sudden Learning

    Science.gov (United States)

    Ash, Ivan K.; Jee, Benjamin D.; Wiley, Jennifer

    2012-01-01

    Gestalt psychologists proposed two distinct learning mechanisms. Associative learning occurs gradually through the repeated co-occurrence of external stimuli or memories. Insight learning occurs suddenly when people discover new relationships within their prior knowledge as a result of reasoning or problem solving processes that re-organize or…

  20. Map Projection Transitions

    Directory of Open Access Journals (Sweden)

    Nedjeljko Frančula

    2013-06-01

    Full Text Available Map Projection Transitions is a very successful web application about map projections. The web page (http://www.jasondavies.com/maps/transition pre­sents a world map with graticule and country borders in the oblique Aitoff projection, with the South Pole. The map is not static, but animated. The South Pole moves toward the bottom and Earth rotates around its poles. The animation lasts five seconds, after which the projection changes and movement continues for five seconds, after which the projection changes again. Names of projections appear in a separate window. There are a total of 56 projections. The South Pole eventually becomes invisible and the North Pole appears at the top. Various parts of Earth appear in the center of the map by rotating around the poles.

  1. Open Land Use Map

    Directory of Open Access Journals (Sweden)

    T. Mildorf

    2014-12-01

    Full Text Available Open Land Use Map is an initiative that has been started by the Plan4business project and that will be extended as part of the SDI4Apps project in the future. This service aims to create an improved worldwide land use map. The initial map will be prepared using the CORINE Land Cover, Global Cover dataset and Open Street Map. Contributors, mainly volunteers, will able to change the geometry and assign up-to-date land use according to the HILUCS specification. For certain regions more detailed datasets, if available, will be used as an update of the Open Land Use Map. The product is treated as Open Data and users will be able to download the data in a specified format and for a selected area. The paper introduces the technical and business aspects of Open Land Use Map app including the integration and harmonisation tools, sustainability plan and apps that accompany the entire platform.

  2. Creativity Development in Adolescence: Insight from Behavior, Brain, and Training Studies

    Science.gov (United States)

    Kleibeuker, Sietske W.; De Dreu, Carsten K. W.; Crone, Eveline A.

    2016-01-01

    Creativity is a multifaceted construct that recruits different cognitive processes. Here, we summarize studies that show that creativity develops considerably during adolescence with different developmental trajectories for insight, verbal divergent thinking, and visuospatial divergent thinking. Next, these developmental time courses are mapped to…

  3. Heat Capacity Mapping Mission

    Science.gov (United States)

    Nilsson, C. S.; Andrews, J. C.; Scully-Power, P.; Ball, S.; Speechley, G.; Latham, A. R. (Principal Investigator)

    1980-01-01

    The Tasman Front was delineated by airborne expendable bathythermograph survey; and an Heat Capacity Mapping Mission (HCMM) IR image on the same day shows the same principal features as determined from ground-truth. It is clear that digital enhancement of HCMM images is necessary to map ocean surface temperatures and when done, the Tasman Front and other oceanographic features can be mapped by this method, even through considerable scattered cloud cover.

  4. Mind mapping management

    OpenAIRE

    Pugalendhi, Subburethina Bharathi; Nakkeeran, Senthil kumar

    2011-01-01

    A mind map is a diagram used to represent words, ideas, tasks, or other items linked to and arranged around a central key word or idea. Mind maps are used to generate, visualize, structure, and classify ideas, and as an aid to studying and organizing information, solving problems, making decisions, and writing. The fundamentals of mind map are arranged naturally according to the importance of the concepts, and are classified into groupings, branches, or areas, with the goal of representing se...

  5. Diametrically Contractive Multivalued Mappings

    Directory of Open Access Journals (Sweden)

    S. Dhompongsa

    2007-06-01

    Full Text Available Diametrically contractive mappings on a complete metric space are introduced by V. I. Istratescu. We extend and generalize this idea to multivalued mappings. An easy example shows that our fixed point theorem is more applicable than a former one obtained by H. K. Xu. A convergence theorem of Picard iteratives is also provided for multivalued mappings on hyperconvex spaces, thereby extending a Proinov's result.

  6. Classification of Lipschitz mappings

    CERN Document Server

    Piasecki, Lukasz

    2013-01-01

    The Lipschitz Condition Nonlinear spectral radius Uniformly lipschitzian mappings Basic Facts on Banach Spaces Convexity The operator norm Dual spaces, reexivity, the weak, and weak* topologiesMean Lipschitz Condition Nonexpansive and mean nonexpansive mappings in Banach spaces General case On the Lipschitz Constants for Iterates of Mean Lipschitzian Mappings A bound for Lipschitz constants of iterates A bound for the constant k∞(T)Moving averages in Bana

  7. Multi-moment maps

    DEFF Research Database (Denmark)

    Swann, Andrew Francis; Madsen, Thomas Bruun

    2012-01-01

    We introduce a notion of moment map adapted to actions of Lie groups that preserve a closed three-form. We show existence of our multi-moment maps in many circumstances, including mild topological assumptions on the underlying manifold. Such maps are also shown to exist for all groups whose secon......-torus symmetry in terms of tri-symplectic geometry of four-manifolds. (C) 2012 Elsevier Inc. All rights reserved....

  8. Similarity transformations of MAPs

    Directory of Open Access Journals (Sweden)

    Andersen Allan T.

    1999-01-01

    Full Text Available We introduce the notion of similar Markovian Arrival Processes (MAPs and show that the event stationary point processes related to two similar MAPs are stochastically equivalent. This holds true for the time stationary point processes too. We show that several well known stochastical equivalences as e.g. that between the H 2 renewal process and the Interrupted Poisson Process (IPP can be expressed by the similarity transformations of MAPs. In the appendix the valid region of similarity transformations for two-state MAPs is characterized.

  9. Obesity Prevalence Maps

    Science.gov (United States)

    ... Breastfeeding Micronutrient Malnutrition State and Local Programs Adult Obesity Prevalence Maps Recommend on Facebook Tweet Share Compartir Obesity Prevalence in 2015 Varies Across States and Territories ...

  10. Vegetation Fuel Mapping

    Directory of Open Access Journals (Sweden)

    A. V. Volokitina

    2014-12-01

    Full Text Available All vegetation sites as objects of burning are structural complexes of various fuels. Especially complex are forest biogeoceonoses. For practical use, pyrological characteristics of vegetation are reflected on plans and maps showing both general one-sided estimations with site descriptions (for example, their fire hazard and detailed multi-sided characteristics of all compounds in the vegetation fuel complexes. The latter become basic maps for obtaining various pyrological estimations and are called vegetation fuel maps. Vegetation fuel (VF mapping can be made using two methodological approaches: first, by distinguishing pyrological vegetation categories as standard complexes; second, by individually characterizing each vegetation site in terms of VF. Obviously, the standard VF characteristic of sites can be only approximate and rough, since the possible number of studied site categories is limited. For large-scale mapping, the detailed individual characteristic of vegetation sites in terms of VF is more preferable and precise but more expensive. Therefore, historically, the first approach to VF mapping got its development, i. e. distinguishing and mapping of certain vegetation categories with standard characteristics. Foreign and Russian methodical approaches to vegetation fuel (VF classification and mapping are considered. Examples of VF mapping at different scales and guidelines for their use are given.

  11. Pharmacogenomics: mapping monogenic mutations to direct therapy.

    Science.gov (United States)

    Taylor, Palmer

    2012-07-01

    The molecular mapping of mutations that underlie congenital disorders of monogenic origin can result in both a broader understanding of the molecular basis of the disorder and novel therapeutic insights. Indeed, genotyping patients and then replicating the behavior of the mutant gene products in well-defined biochemical or electrophysiological systems will allow tailoring of therapy to be mutation- and protein sequence-dependent. In this issue of the JCI, Shen and colleagues describe such an approach that identified novel mutations in the α subunit of the nicotinic receptor linked to myasthenia gravis. PMID:22728931

  12. Latest Insights on Adenovirus Structure and Assembly

    Directory of Open Access Journals (Sweden)

    Carmen San Martín

    2012-05-01

    Full Text Available Adenovirus (AdV capsid organization is considerably complex, not only because of its large size (~950 Å and triangulation number (pseudo T = 25, but also because it contains four types of minor proteins in specialized locations modulating the quasi-equivalent icosahedral interactions. Up until 2009, only its major components (hexon, penton, and fiber had separately been described in atomic detail. Their relationships within the virion, and the location of minor coat proteins, were inferred from combining the known crystal structures with increasingly more detailed cryo-electron microscopy (cryoEM maps. There was no structural information on assembly intermediates. Later on that year, two reports described the structural differences between the mature and immature adenoviral particle, starting to shed light on the different stages of viral assembly, and giving further insights into the roles of core and minor coat proteins during morphogenesis [1,2]. Finally, in 2010, two papers describing the atomic resolution structure of the complete virion appeared [3,4]. These reports represent a veritable tour de force for two structural biology techniques: X-ray crystallography and cryoEM, as this is the largest macromolecular complex solved at high resolution by either of them. In particular, the cryoEM analysis provided an unprecedented clear picture of the complex protein networks shaping the icosahedral shell. Here I review these latest developments in the field of AdV structural studies.

  13. Lyman Alpha Mapping Project (LAMP) Brightness Maps

    Science.gov (United States)

    Retherford, Kurt D.; Gladstone, G.; Stern, S.; Egan, A. F.; Miles, P. F.; Parker, J. W.; Greathouse, T. K.; Davis, M. W.; Slater, D. C.; Kaufmann, D. E.; Versteeg, M. H.; Feldman, P. D.; Hurley, D. M.; Pryor, W. R.; Hendrix, A. R.

    2010-10-01

    The Lyman Alpha Mapping Project (LAMP) is an ultraviolet (UV) spectrograph on the Lunar Reconnaissance Orbiter (LRO) that is designed to map the lunar albedo at far-UV wavelengths. LAMP primarily measures interplanetary Hydrogen Lyman-alpha sky-glow and far-UV starlight reflected from the night-side lunar surface, including permanently shadowed regions (PSRs) near the poles. Dayside observations are also obtained. Brightness maps sorted by wavelength (including the Lyman-alpha wavelength of 121.6 nm) are reported for the polar regions, with a few regions of interest reported in more detail. LAMP's spectral range of 58 nm to 196 nm includes a water ice spectral feature near 160 nm, which provides a diagnostic tool for detecting water on the lunar surface that is complementary to recent discoveries using infrared and radio frequency techniques. Progress towards producing far-UV albedo maps and searching for water ice signatures will be reported. We'll discuss how LAMP data may address questions regarding how water is formed on the moon, transported through the lunar atmosphere, and deposited in the PSRs.

  14. On circle map coupled map lattice

    CERN Document Server

    Ahmed, E

    2002-01-01

    Circle map in one and two dimensions is studied. Both its stability, synchronization using bounded control and persistence is discussed. This work is expected to be applicable in ecology where spatial effects are known to be important. Also it will be relevant to systems where delay effects are not negligible.

  15. Acoustic mapping velocimetry

    Science.gov (United States)

    Muste, M.; Baranya, S.; Tsubaki, R.; Kim, D.; Ho, H.; Tsai, H.; Law, D.

    2016-05-01

    Knowledge of sediment dynamics in rivers is of great importance for various practical purposes. Despite its high relevance in riverine environment processes, the monitoring of sediment rates remains a major and challenging task for both suspended and bed load estimation. While the measurement of suspended load is currently an active area of testing with nonintrusive technologies (optical and acoustic), bed load measurement does not mark a similar progress. This paper describes an innovative combination of measurement techniques and analysis protocols that establishes the proof-of-concept for a promising technique, labeled herein Acoustic Mapping Velocimetry (AMV). The technique estimates bed load rates in rivers developing bed forms using a nonintrusive measurements approach. The raw information for AMV is collected with acoustic multibeam technology that in turn provides maps of the bathymetry over longitudinal swaths. As long as the acoustic maps can be acquired relatively quickly and the repetition rate for the mapping is commensurate with the movement of the bed forms, successive acoustic maps capture the progression of the bed form movement. Two-dimensional velocity maps associated with the bed form migration are obtained by implementing algorithms typically used in particle image velocimetry to acoustic maps converted in gray-level images. Furthermore, use of the obtained acoustic and velocity maps in conjunction with analytical formulations (e.g., Exner equation) enables estimation of multidirectional bed load rates over the whole imaged area. This paper presents a validation study of the AMV technique using a set of laboratory experiments.

  16. Map-A-Planet

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Map-A-Planet website allows users to create and download custom image maps of planets and satellites from a variety of missions in an easy to use web interface

  17. Multivariate Nonnegative Quadratic Mappings

    NARCIS (Netherlands)

    Luo, Z-Q; Sturm, J.F.; Zhang, S.

    2003-01-01

    In this paper we study several issues related to the characterization of speci c classes of multivariate quadratic mappings that are nonnegative over a given domain, with nonnegativity de ned by a pre-speci ed conic order.In particular, we consider the set (cone) of nonnegative quadratic mappings de

  18. Android Mapping Application

    Directory of Open Access Journals (Sweden)

    Abdalwhab Bakheet

    2014-04-01

    Full Text Available Location-aware and mapping applications have gone f rom a desirable feature to an essential part of any smart phone. Whether a user is checking into a social network, looking for a pharmacy in the middle of the night, or located in somewhere and needs help, the key is always the same: location. In this project, an Android mapping application is developed. The application is able to display the map of the whole world while online or, display a pre-downloaded map while offline, track the user’s location, display a compass to determine north, send the user’s location to others in case of emergency using SMS, receive and interpret received location from the message, display it on the map, and notify the user by the reception of the location. The application was developed using agile methodol ogy. It, met its objectives and successfully passed 91% of the final system test, recording that some limitations were discovered, the application needs further testing and can be implem ented for particular company or university using their own maps or editing the maps in OSM (op en street maps.

  19. Iconicity as structure mapping.

    Science.gov (United States)

    Emmorey, Karen

    2014-09-19

    Linguistic and psycholinguistic evidence is presented to support the use of structure-mapping theory as a framework for understanding effects of iconicity on sign language grammar and processing. The existence of structured mappings between phonological form and semantic mental representations has been shown to explain the nature of metaphor and pronominal anaphora in sign languages. With respect to processing, it is argued that psycholinguistic effects of iconicity may only be observed when the task specifically taps into such structured mappings. In addition, language acquisition effects may only be observed when the relevant cognitive abilities are in place (e.g. the ability to make structural comparisons) and when the relevant conceptual knowledge has been acquired (i.e. information key to processing the iconic mapping). Finally, it is suggested that iconicity is better understood as a structured mapping between two mental representations than as a link between linguistic form and human experience.

  20. Geologic map of Mars

    Science.gov (United States)

    Tanaka, Kenneth L.; Skinner, James A.; Dohm, James M.; Irwin, Rossman P.; Kolb, Eric J.; Fortezzo, Corey M.; Platz, Thomas; Michael, Gregory G.; Hare, Trent M.

    2014-01-01

    This global geologic map of Mars, which records the distribution of geologic units and landforms on the planet's surface through time, is based on unprecedented variety, quality, and quantity of remotely sensed data acquired since the Viking Orbiters. These data have provided morphologic, topographic, spectral, thermophysical, radar sounding, and other observations for integration, analysis, and interpretation in support of geologic mapping. In particular, the precise topographic mapping now available has enabled consistent morphologic portrayal of the surface for global mapping (whereas previously used visual-range image bases were less effective, because they combined morphologic and albedo information and, locally, atmospheric haze). Also, thermal infrared image bases used for this map tended to be less affected by atmospheric haze and thus are reliable for analysis of surface morphology and texture at even higher resolution than the topographic products.

  1. Application of ecological mapping

    International Nuclear Information System (INIS)

    The US Fish and Wildlife Service has initiated the production of a comprehensive ecological inventory map series for use as a major new planning tool. Important species data along with special land use designations are displayed on 1:250,000 scale topographic base maps. Sets of maps have been published for the Atlantic and Pacific coastal areas of the United States. Preparation of a map set for the Gulf of Mexico is underway at the present time. Potential application of ecological inventory map series information to a typical land disposal facility could occur during the narrowing of the number of possible disposal sites, the design of potential disposal site studies of ecological resources, the preparation of the environmental report, and the regulatory review of license applications. 3 figures, 3 tables

  2. Philosophical Insight and Modal Cognition

    OpenAIRE

    Gerken, Mikkel

    2015-01-01

    Modal rationalists uphold a strong constitutive relationship between a priori cognition and modal cognition. Since both a priori cognition and modal cognition have been taken to be characteristic of philosophical insights, I will critically assess an ambitious modal rationalism and an associated ambitious methodological rationalism. I begin by examining Kripkean cases of the necessary a posteriori in order to characterize the ambitious modal rationalism that will be the focus of my criticism....

  3. Theoretical Insight into Shocked Gases

    Energy Technology Data Exchange (ETDEWEB)

    Leiding, Jeffery Allen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-09-29

    I present the results of statistical mechanical calculations on shocked molecular gases. This work provides insight into the general behavior of shock Hugoniots of gas phase molecular targets with varying initial pressures. The dissociation behavior of the molecules is emphasized. Impedance matching calculations are performed to determine the maximum degree of dissociation accessible for a given flyer velocity as a function of initial gas pressure.

  4. Study on location diagnosis of epilepsia by 99mTc-ECD brain SPECT rCBF imaging%局部脑血流SPECT显像与其他影像对癫痫定位诊断比较的研究

    Institute of Scientific and Technical Information of China (English)

    李志刚; 杨谦; 张维; 王林; 周建平

    2005-01-01

    目的:研究癫痫发作期与发作间期同侧对照99mTc-ECD局部脑血流(rCBF)单光子发射计算机体层摄影术(SPECT)显像对癫痫灶的定位诊断价值.方法:对54例癫痫患者行发作间期显像,其中10例行发作期显像,并与皮层脑电图(EEG)、计算机断层扫描或磁共振显像(CT/MRI)、深部皮层脑电图(EcoG)结果进行对比分析.结果:癫痫发作期与发作间期rGBF SPECT显像对癫痫灶具有较高的检出率和定位率,优于EEG、CT/MRI,低于EcoG,但rCBF在发作期与发作间期的比较差异无显著性(P>0.05).结论:发作间期rCBF SPECT显像可以成为癫痫灶方便而有效的定位方法,若加上发作期rCBF显像则定位更佳.

  5. Mapping permafrost with airborne electromagnetics

    Science.gov (United States)

    Minsley, B. J.; Ball, L. B.; Bloss, B. R.; Kass, A.; Pastick, N.; Smith, B. D.; Voss, C. I.; Walsh, D. O.; Walvoord, M. A.; Wylie, B. K.

    2014-12-01

    Permafrost is a key characteristic of cold region landscapes, yet detailed assessments of how the subsurface distribution of permafrost impacts the environment, hydrologic systems, and infrastructure are lacking. Data acquired from several airborne electromagnetic (AEM) surveys in Alaska provide significant new insight into the spatial extent of permafrost over larger areas (hundreds to thousands of square kilometers) than can be mapped using ground-based geophysical methods or through drilling. We compare several AEM datasets from different areas of interior Alaska, and explore the capacity of these data to infer geologic structure, permafrost extent, and related hydrologic processes. We also assess the impact of fires on permafrost by comparing data from different burn years within similar geological environments. Ultimately, interpretations rely on understanding the relationship between electrical resistivity measured by AEM surveys and the physical properties of interest such as geology, permafrost, and unfrozen water content in the subsurface. These relationships are often ambiguous and non-unique, so additional information is useful for reducing uncertainty. Shallow (upper ~1m) permafrost and soil characteristics identified from remotely sensed imagery and field observations help to constrain and aerially extend near-surface AEM interpretations, where correlations between the AEM and remote sensing data are identified using empirical multivariate analyses. Surface nuclear magnetic resonance (sNMR) measurements quantify the contribution of unfrozen water at depth to the AEM-derived electrical resistivity models at several locations within one survey area. AEM surveys fill a critical data gap in the subsurface characterization of permafrost environments and will be valuable in future mapping and monitoring programs in cold regions.

  6. Mental Mapping: A Classroom Strategy

    Science.gov (United States)

    Solomon, Les

    1978-01-01

    Examines potential uses of mental maps in the classroom by reviewing research efforts, providing an example of the differences between mental maps of two student groups, and suggesting how to use mental maps in the geography curriculum. Mental mapping (or cognitive mapping) refers to individuals' processes of collecting, storing, and retrieving…

  7. nowCOAST's Map Service for Political Map Overlays

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Map Information: This nowCOAST map service provides map overlays depicting the boundaries of U.S. states, territories, counties and townships/county subdivisions,...

  8. nowCOAST's Map Service for Transportation Map Overlays

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Map Information: This nowCOAST map service provides maps depicting the locations of major world airport runways, major U.S. seaports, and latitude/longitude grid...

  9. Assessment of Cerebral Hemodynamic Changes in Pediatric Patients with Moyamoya Disease Using Probabilistic Maps on Analysis of Basal/Acetazolamide Stress Brain Perfusion SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ho Young; Lee, Jae Sung; Kim, Seung Ki; Wang, Kyu Chang; Cho, Byung Kyu; Chung, June Key; Lee, Myung Chul; Lee, Dong Soo [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2008-06-15

    To evaluate the hemodynamic changes and the predictive factors of the clinical outcome in pediatric patients with moyamoya disease, we analyzed pre/post basal/acetazolamide stress brain perfusion SPECT with automated volume of interest (VOIs) method. Total fifty six (M:F=33:24, age 6.7{+-}3.2 years) pediatric patients with moyamoya disease, who underwent basal/acetazolamide stress brain perfusion SPECT within 6 before and after revascularization surgery (encephalo-duro-arterio-synangiosis (EDAS) with frontal encephalo-galeo-synangiosis (EGS) and EDAS only followed on contralateral hemisphere), and followed-up more than 6 months after post-operative SPECT, were included. A mean follow-up period after post-operative SPECT was 33{+-}21 months. Each patient's SPECT image was spatially normalized to Korean template with the SPM2. For the regional count normalization, the count of pons was used as a reference region. The basal/acetazolamide-stressed cerebral blood flow (CBF), the cerebral vascular reserve index (CVRI), and the extent of area with significantly decreased basal/acetazolamide- stressed rCBF than age-matched normal control were evaluated on both medial frontal, frontal, parietal, occipital lobes, and whole brain in each patient's images. The post-operative clinical outcome was assigned as good, poor according to the presence of transient ischemic attacks and/or fixed neurological deficits by pediatric neurosurgeon. In a paired t-test, basal/acetazolamide-stressed rCBF and the CVRI were significantly improved after revascularization (p<0.05). The significant difference in the pre-operative basal/acetazolamide-stressed rCBF and the CVRI between the hemispheres where EDAS with frontal EGS was performed and their contralateral counterparts where EDAS only was done disappeared after operation (p<0.05). In an independent student t-test, the pre-operative basal rCBF in the medial frontal gyrus, the post-operative CVRI in the frontal lobe and the parietal

  10. Quantifying the Qualitative: Measuring the Insight Experience

    Science.gov (United States)

    Jarman, Matthew S.

    2014-01-01

    No scales currently exist that measure variability in the insight experience. Two scales were created to measure two factors hypothesized to be key drivers of the insight experience: insight radicality (i.e., perceived deviation between previous and new problem representations) and restructuring experience (i.e., the subjective experience of the…

  11. Color on emergency mapping

    Science.gov (United States)

    Jiang, Lili; Qi, Qingwen; Zhang, An

    2007-06-01

    There are so many emergency issues in our daily life. Such as typhoons, tsunamis, earthquake, fires, floods, epidemics, etc. These emergencies made people lose their lives and their belongings. Every day, every hour, even every minute people probably face the emergency, so how to handle it and how to decrease its hurt are the matters people care most. If we can map it exactly before or after the emergencies; it will be helpful to the emergency researchers and people who live in the emergency place. So , through the emergency map, before emergency is occurring we can predict the situation, such as when and where the emergency will be happen; where people can refuge, etc. After disaster, we can also easily assess the lost, discuss the cause and make the lost less. The primary effect of mapping is offering information to the people who care about the emergency and the researcher who want to study it. Mapping allows the viewers to get a spatial sense of hazard. It can also provide the clues to study the relationship of the phenomenon in emergency. Color, as the basic element of the map, it can simplify and clarify the phenomenon. Color can also affects the general perceptibility of the map, and elicits subjective reactions to the map. It is to say, structure, readability, and the reader's psychological reactions can be affected by the use of color.

  12. Blind Friendly Maps

    OpenAIRE

    Červenka, Petr; Břinda, Karel; Seifert, Radek; Hofman, Petr

    2016-01-01

    Space concept of the surrounding area is one of the most important preconditions of the independent mobility and orientation of the blind people. Tactile maps are considered to be the most appropriate source of spatial information. One of the main problems of the tactile maps usage is their problematic accessibility for the blind users since they are not available in time and with up-to-date content. The map production is a matter of tedious manual work and a result of expensive and time-cons...

  13. Diffusion Based Photon Mapping

    DEFF Research Database (Denmark)

    Schjøth, Lars; Olsen, Ole Fogh; Sporring, Jon

    2006-01-01

    . To address this problem we introduce a novel photon mapping algorithm based on nonlinear anisotropic diffusion. Our algorithm adapts according to the structure of the photon map such that smoothing occurs along edges and structures and not across. In this way we preserve the important illumination features......Density estimation employed in multi-pass global illumination algorithms give cause to a trade-off problem between bias and noise. The problem is seen most evident as blurring of strong illumination features. In particular this blurring erodes fine structures and sharp lines prominent in caustics......, while eliminating noise. We call our method diffusion based photon mapping....

  14. Map: Geospatial paradigm

    OpenAIRE

    Ikonović Vesna

    2006-01-01

    There are different definitions of map. There is no one which is accepted in whole world or at least from the most cartographers. In the paper it will be given several definitions which are, at the best way, (according to the author’s opinion) reflecting essence of map as a model of reality. Map as a universal meaning of researching can’t serve only for representing particular geospace (spatial system) or some its element, or to give only clear view about geographical dispersion of objects, p...

  15. Map: Geospatial paradigm

    Directory of Open Access Journals (Sweden)

    Ikonović Vesna

    2006-01-01

    Full Text Available There are different definitions of map. There is no one which is accepted in whole world or at least from the most cartographers. In the paper it will be given several definitions which are, at the best way, (according to the author’s opinion reflecting essence of map as a model of reality. Map as a universal meaning of researching can’t serve only for representing particular geospace (spatial system or some its element, or to give only clear view about geographical dispersion of objects, phenomena and processes, but have to make possible studying the patterns of that dispersion, as well as their mutual connections and conditions.

  16. New insights into coupling and uncoupling of cerebral blood flow and metabolism in the brain.

    Science.gov (United States)

    Venkat, Poornima; Chopp, Michael; Chen, Jieli

    2016-06-30

    The brain has high metabolic and energy needs and requires continuous cerebral blood flow (CBF), which is facilitated by a tight coupling between neuronal activity, CBF, and metabolism. Upon neuronal activation, there is an increase in energy demand, which is then met by a hemodynamic response that increases CBF. Such regional CBF increase in response to neuronal activation is observed using neuroimaging techniques such as functional magnetic resonance imaging and positron emission tomography. The mechanisms and mediators (eg, nitric oxide, astrocytes, and ion channels) that regulate CBF-metabolism coupling have been extensively studied. The neurovascular unit is a conceptual model encompassing the anatomical and metabolic interactions between the neurons, vascular components, and glial cells in the brain. It is compromised under disease states such as stroke, diabetes, hypertension, dementias, and with aging, all of which trigger a cascade of inflammatory responses that exacerbate brain damage. Hence, tight regulation and maintenance of neurovascular coupling is central for brain homeostasis. This review article also discusses the waste clearance pathways in the brain such as the glymphatic system. The glymphatic system is a functional waste clearance pathway that removes metabolic wastes and neurotoxins from the brain along paravascular channels. Disruption of the glymphatic system burdens the brain with accumulating waste and has been reported in aging as well as several neurological diseases. PMID:27374823

  17. Northern Hemisphere Synoptic Weather Maps

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Daily Series of Synoptic Weather Maps. Part I consists of plotted and analyzed daily maps of sea-level and 500-mb maps for 0300, 0400, 1200, 1230, 1300, and 1500...

  18. Two-dimensional Value Stream Mapping: Integrating the design of the MPC system in the value stream map

    DEFF Research Database (Denmark)

    Powell, Daryl; Olesen, Peter Bjerg

    2013-01-01

    Companies use value stream mapping to identify waste, often in the early stages of a lean implementation. Though the tool helps users to visualize material and information flows and to identify improvement opportunities, a limitation of this approach is the lack of an integrated method for analys......Companies use value stream mapping to identify waste, often in the early stages of a lean implementation. Though the tool helps users to visualize material and information flows and to identify improvement opportunities, a limitation of this approach is the lack of an integrated method...... for analysing and re-designing the MPC system in order to support lean improvement. We reflect on the current literature regarding value stream mapping, and use practical insights in order to develop and propose a two-dimensional value stream mapping tool that integrates the design of the MPC system within...

  19. The INSIGHT SEIS VBB Experiment

    Science.gov (United States)

    Tillier, S.; De Raucourt, S.; Lognonne, P. H.; Banerdt, B.; Mimoun, D.; Giardini, D.; Christensen, U. R.; Pike, W. T.; Zweifel, P.; Mance, D.; Bierwirth, M.; Laudet, P.; Perez, R.; Kerjean, L.; Hurst, K. J.; Mocquet, A.; Garcia, R. F.

    2012-12-01

    The SEIS experiment is the primary payload of the Interior Structure investigation using Seismology and Heat Transport (INSIGHT) Mission Proposal, submitted to NASA in the frame of the 2010 Discovery program, and selected for a competitive phase A study, together with two other projects. The objective of the INSIGHT SEIS experiment is the determination of the deep internal structure of Mars. In particular, geophysical parameters of first importance, such as the state (liquid/solid) and size of the core, structure of the mantle, shape of discontinuities, thickness of the crust will be determined by the experiment. It will measure seismic activity in a very broad band of signal, from the tidal frequencies (0.05 mHz) up to the short period frequencies (50 Hz), to address the widest range of scientific questions, from the state of the core to the meteoritic impact and quake rates. The instrument integrates a Very Broad Band (VBB) 3 axis seismometer, completed by another trihedron of MEMS short period seismometers, environmental sensors for pressure, wind and temperature, The sensors will be deployed on the Martian ground by a robotic arm from a Phoenix-type lander platform and protected by a wind and thermal shield. The sensor assembly, which contains all seismic sensors, the leveling system, as well as house-keeping and temperature measurements, will be deployed on the soil in order to allow the best possible mechanical coupling with the ground motion. The wind and thermal shield, the sensors' specific containers (vacuum sphere for VBBs) and a passive thermal compensation system will achieve a very high protection of the VBB against temperature and pressure variations, allowing the sensor to operate in the rough Martian thermal environment while reaching a deection threshold below 10-9 ms-2 Hz-1/2 in the VBB bandwidth. A dedicated electronics will manage the overall experiment and ultra-low noise, space qualified 24 bits A/D converters will perform the acquisition

  20. Irreducibility properties of Keller maps

    OpenAIRE

    de Bondt, Michiel; Yan, Dan

    2013-01-01

    Jedrzejewicz showed that a polynomial map over a field of characteristic zero is invertible, if and only if the corresponding endomorphism maps irreducible polynomials to irreducible polynomials. Furthermore, he showed that a polynomial map over a field of characteristic zero is a Keller map, if and only if the corresponding endomorphism maps irreducible polynomials to square-free polynomials. We show that the latter endomorphism maps other square-free polynomials to square-free polynomials a...

  1. MAPPING IN MICRONESIA.

    Science.gov (United States)

    Olsen, Randle W.; Swinnerton, J.R.

    1984-01-01

    The U. S. Geological Survey has recently completed a series of new topographic maps of Micronesia in cooperation with the Trust Territory of the Pacific Islands, the Federal agency administering the islands. Monocolor 1:10,000-scale manuscripts were compiled, from which 1:25,000-scale metric quadrangles were derived with symbology consistent with USGS quadrangle mapping. The publication of these new maps coincides with the impending political changes resulting from self-determination referendums held in Micronesia. Local sources have helped considerably with field logistics and resolution of geographic name controversies. Technical aspects of this project included development of tropical feature symbology, location of cadastral subdivisions and associated boundaries and mapping of many outlying coral reefs.

  2. The CPD Maps System

    Data.gov (United States)

    Department of Housing and Urban Development — CPD Maps includes data on the locations of existing CDBG, HOME, public housing and other HUD-funded community assets, so that users can view past investments...

  3. Interest rates mapping

    CERN Document Server

    Kanevski, M; Pozdnoukhov, A; Timonin, V

    2007-01-01

    The present study deals with the analysis and mapping of Swiss franc interest rates. Interest rates depend on time and maturity, defining term structure of the interest rate curves (IRC). In the present study IRC are considered in a two-dimensional feature space - time and maturity. Geostatistical models and machine learning algorithms (multilayer perceptron and Support Vector Machines) were applied to produce interest rate maps. IR maps can be used for the visualisation and patterns perception purposes, to develop and to explore economical hypotheses, to produce dynamic asses-liability simulations and for the financial risk assessments. The feasibility of an application of interest rates mapping approach for the IRC forecasting is considered as well.

  4. MUTYH Associated Polyposis (MAP)

    DEFF Research Database (Denmark)

    Poulsen, Marie Louise Mølgaard; Bisgaard, M L

    2008-01-01

    MUTYH Associated Polyposis (MAP), a Polyposis predisposition caused by biallelic mutations in the Base Excision Repair (BER) gene MUTYH, confers a marked risk of colorectal cancer (CRC). The MAP phenotype is difficult to distinguish from other hereditary CRC syndromes. Especially from Familial...... Adenomatous Polyposis (FAP) and to a lesser extend Lynch Syndrome, which are caused by germline mutations in the APC and Mismatch Repair (MMR) genes, respectively.Here we review research findings regarding MUTYH interactions, genotypic and phenotypic characteristics of MAP, as well as surveillance...... and treatment of the disease. The applied papers, published between 1/1 2002- 1/2 2008, were found through PubMed.The exact role of MUTYH in CRC tumorgenesis is still uncertain, although MAP tumors show distinct molecular features, including somatic G:C>T:A transversions in the APC gene. Furthermore...

  5. Daily Weather Maps

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Several different government offices have published the Daily weather maps over its history. The publication has also gone by different names over time. The U.S....

  6. PDS Planetary Maps API

    Data.gov (United States)

    National Aeronautics and Space Administration — We are developing a set of NASA Extensions to the Google Maps API—and soon to other frameworks such as OpenLayers as well—that will make these platforms more useful...

  7. NOS Bathymetric Maps

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This collection of bathymetric contour maps which represent the seafloor topography includes over 400 individual titles and covers US offshore areas including...

  8. Minidoka - Invasive Species Mapping

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Locate and map, via the use of GPS, Rush skeletonweed on the refuge. Located areas then entered into GIS to allow refuge staff to pin point locations and treat this...

  9. Mapping the HISS Dipole

    International Nuclear Information System (INIS)

    The principal component of the Bevalac HISS facility is a large super-conducting 3 Tesla dipole. The facility's need for a large magnetic volume spectrometer resulted in a large gap geometry - a 2 meter pole tip diameter and a 1 meter pole gap. Obviously, the field required detailed mapping for effective use as a spectrometer. The mapping device was designed with several major features in mind. The device would measure field values on a grid which described a closed rectangular solid. The grid would be a regular with the exact measurement intervals adjustable by software. The device would function unattended over the long period of time required to complete a field map. During this time, the progress of the map could be monitored by anyone with access to the HISS VAX computer. Details of the mechanical, electrical, and control design follow

  10. TOXMAP®: Environmental Health Maps

    Data.gov (United States)

    U.S. Department of Health & Human Services — TOXMAP® is a Geographic Information System (GIS) that uses maps of the United States and Canada to help users visually explore data primarily from the EPA's Toxics...

  11. Haz-Map

    Data.gov (United States)

    U.S. Department of Health & Human Services — Haz-Map is an occupational health database designed for health and safety professionals and for consumers seeking information about the adverse effects of workplace...

  12. FLOODPLAIN MAPPING, Bandera, TEXAS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Floodplain Mapping/Redelineation study deliverables depict and quantify the flood risks for the study area. The primary risk classifications used are the...

  13. MetaMap

    Data.gov (United States)

    U.S. Department of Health & Human Services — MetaMap is a highly configurable application developed by the Lister Hill National Center for Biomedical Communications at the National Library of Medicine (NLM) to...

  14. Programming with Hierarchical Maps

    DEFF Research Database (Denmark)

    Ørbæk, Peter

    This report desribes the hierarchical maps used as a central data structure in the Corundum framework. We describe its most prominent features, ague for its usefulness and briefly describe some of the software prototypes implemented using the technology....

  15. National Coastal Mapping Program

    Data.gov (United States)

    Army Corps of Engineers, Department of the Army, Department of Defense — The U. S. Army Corps of Engineers (USACE) National Coastal Mapping Program (NCMP) is designed to provide high-resolution elevation and imagery data along U.S....

  16. Marketplace Enrollment Maps

    Data.gov (United States)

    U.S. Department of Health & Human Services — The maps show the distribution of consumers in a state who enrolled in marketplace plans through federally facilitated, partnership, and supported state-based...

  17. Public Waters Inventory Maps

    Data.gov (United States)

    Minnesota Department of Natural Resources — This theme is a scanned and rectified version of the Minnesota DNR - Division of Waters "Public Waters Inventory" (PWI) maps. DNR Waters utilizes a small scale...

  18. Uncertainties in ecosystem service maps: a comparison on the European scale.

    Science.gov (United States)

    Schulp, Catharina J E; Burkhard, Benjamin; Maes, Joachim; Van Vliet, Jasper; Verburg, Peter H

    2014-01-01

    Safeguarding the benefits that ecosystems provide to society is increasingly included as a target in international policies. To support such policies, ecosystem service maps are made. However, there is little attention for the accuracy of these maps. We made a systematic review and quantitative comparison of ecosystem service maps on the European scale to generate insights in the uncertainty of ecosystem service maps and discuss the possibilities for quantitative validation. Maps of climate regulation and recreation were reasonably similar while large uncertainties among maps of erosion protection and flood regulation were observed. Pollination maps had a moderate similarity. Differences among the maps were caused by differences in indicator definition, level of process understanding, mapping aim, data sources and methodology. Absence of suitable observed data on ecosystem services provisioning hampers independent validation of the maps. Consequently, there are, so far, no accurate measures for ecosystem service map quality. Policy makers and other users need to be cautious when applying ecosystem service maps for decision-making. The results illustrate the need for better process understanding and data acquisition to advance ecosystem service mapping, modelling and validation.

  19. Takotsubo Syndrome: Insights from Japan.

    Science.gov (United States)

    Akashi, Yoshihiro J; Ishihara, Masaharu

    2016-10-01

    We report the history and new insights of takotsubo syndrome based on the achievements that Japanese researchers have contributed and summarize the evidence originally presented from Japan. Takotsubo syndrome is a newly described heart failure characterized by transient left ventricular dysfunction. We should be aware of this entity as a syndrome, not actual cardiomyopathy. Japanese researchers focus on the experimental approaches for clinical diagnosis and treatment of takotsubo syndrome. As representatives from a country originally naming this syndrome takotsubo, a global registry for takotsubo syndrome including Japan should be established.

  20. Complete Quasiconvex Mappings in Polydisc

    Institute of Scientific and Technical Information of China (English)

    LIU Tai-shun; ZHANG Wen-jun

    2006-01-01

    In this paper,a class of biholomorphic mappings called complete quasiconvex mappings is introduced and studied in bounded convex Reinhardt domains of Cn.Through a detailed analysis of the analytic characterization for this class of mappings,it is shown that this class of mappings contains the convex mappings and is also a subset of the class of starlike mappings.In the special case of the polydisc,a decomposition theorem is established for the complete quasiconvex mappings,which in turn is used to derive an improved sufficient condition for the convex mappings.

  1. Approaching the Distinction between Intuition and Insight.

    Science.gov (United States)

    Zhang, Zhonglu; Lei, Yi; Li, Hong

    2016-01-01

    Intuition and insight share similar cognitive and neural basis. Though, there are still some essential differences between the two. Here in this short review, we discriminated between intuition, and insight in two aspects. First, intuition, and insight are toward different aspects of information processing. Whereas intuition involves judgment about "yes or no," insight is related to "what" is the solution. Second, tacit knowledge play different roles in between intuition and insight. On the one hand, tacit knowledge is conducive to intuitive judgment. On the other hand, tacit knowledge may first impede but later facilitate insight occurrence. Furthermore, we share theoretical, and methodological views on how to access the distinction between intuition and insight. PMID:27555833

  2. Random mapping statistics

    OpenAIRE

    Flajolet, Philippe; Odlyzko, Andrew M.

    1989-01-01

    Random mappings from a finite set into itself are either a heuristic or an exact model for a variety of applications in random number generation, computational number theory, cryptography, and the analysis of algorithms at large. This paper introduces a general framework in which the analysis of about twenty characteristic parameters of random mappings is carried out. These parameters are studied systematically through the use of generating functions and singularity analysis. In particular, a...

  3. Sri Lanka Malaria Maps

    OpenAIRE

    Hoek Wim; Gunawardena Dissanayake M; Briët Olivier JT; Amerasinghe Felix P

    2003-01-01

    Abstract Background Despite a relatively good national case reporting system in Sri Lanka, detailed maps of malaria distribution have not been publicly available. Methods In this study, monthly records over the period 1995 – 2000 of microscopically confirmed malaria parasite positive blood film readings, at sub-district spatial resolution, were used to produce maps of malaria distribution across the island. Also, annual malaria trends at district resolution were displayed for the period 1995 ...

  4. Olympic Maps Available

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Beijing is publishing a set of Olympic maps covering everything from the location of sporting venues to the city’s history As soon as Zhou Liyi hopped off the train from Shanghai to Beijing, he hurried to Wangfujing Xinhua Book Store,one of the largest of its kind in Beijing,to buy an Olympic map. Zhou is a Shanghai resident who came to Beijing on business and plans to return as a

  5. Ogallala Aquifer Mapping Program

    International Nuclear Information System (INIS)

    A computerized data file has been established which can be used efficiently by the contour-plotting program SURFACE II to produce maps of the Ogallala aquifer in 17 counties of the Texas Panhandle. The data collected have been evaluated and compiled into three sets, from which SURFACE II can generate maps of well control, aquifer thickness, saturated thickness, water level, and the difference between virgin (pre-1942) and recent (1979 to 1981) water levels. 29 figures, 1 table

  6. Irreversible quantum baker map.

    Science.gov (United States)

    Łoziński, Artur; Pakoński, Prot; Zyczkowski, Karol

    2002-12-01

    We propose a generalization of the model of classical baker map on the torus, in which the images of two parts of the phase space do overlap. This transformation is irreversible and cannot be quantized by means of a unitary Floquet operator. A corresponding quantum system is constructed as a completely positive map acting in the space of density matrices. We investigate spectral properties of this superoperator and their link with the increase of the entropy of initially pure states.

  7. Irreversible Quantum Baker Map

    CERN Document Server

    Lozinski, A; Zyczkowski, K; Lozinski, Artur; Pakonski, Prot; Zyczkowski, Karol

    2002-01-01

    We propose a generalization of the model of classical baker map on the torus, in which the images of two parts of the phase space do overlap. This transformation is irreversible and cannot be quantized by means of a unitary Floquet operator. A corresponding quantum system is constructed as a completely positive map acting in the space of density matrices. We investigate spectral properties of this super-operator and their link with the increase of the entropy of initially pure states.

  8. Maps of Computer Science

    CERN Document Server

    Fried, Daniel

    2013-01-01

    We describe a practical approach for visual exploration of research papers. Specifically, we use the titles of papers from the DBLP database to create what we call maps of computer science (MoCS). Words and phrases from the paper titles are the cities in the map, and countries are created based on word and phrase similarity, calculated using co-occurrence. With the help of heatmaps, we can visualize the profile of a particular conference or journal over the base map. Similarly, heatmap profiles can be made of individual researchers or groups such as a department. The visualization system also makes it possible to change the data used to generate the base map. For example, a specific journal or conference can be used to generate the base map and then the heatmap overlays can be used to show the evolution of research topics in the field over the years. As before, individual researchers or research groups profiles can be visualized using heatmap overlays but this time over the journal or conference base map. Fin...

  9. Interactive Metro Map Editing.

    Science.gov (United States)

    Wang, Yu-Shuen; Peng, Wan-Yu

    2016-02-01

    Manual editing of a metro map is essential because many aesthetic and readability demands in map generation cannot be achieved by using a fully automatic method. In addition, a metro map should be updated when new metro lines are developed in a city. Considering that manually designing a metro map is time-consuming and requires expert skills, we present an interactive editing system that considers human knowledge and adjusts the layout to make it consistent with user expectations. In other words, only a few stations are controlled and the remaining stations are relocated by our system. Our system supports both curvilinear and octilinear layouts when creating metro maps. It solves an optimization problem, in which even spaces, route straightness, and maximum included angles at junctions are considered to obtain a curvilinear result. The system then rotates each edge to extend either vertically, horizontally, or diagonally while approximating the station positions provided by users to generate an octilinear layout. Experimental results, quantitative and qualitative evaluations, and user studies show that our editing system is easy to use and allows even non-professionals to design a metro map.

  10. 东莞大蕉超表达拟南芥GBF1基因及其抗寒性检测%Over-Expression of the Arabidopsis CBF1 Gene in Dongguandajiao (Musa spp.ABB group) and Detection of Its Cold Resistance

    Institute of Scientific and Technical Information of China (English)

    刘凯; 胡春华; 杜发秀; 张玉娥; 魏岳荣; 易干军

    2012-01-01

    [目的]研究超表达拟南芥CBF1基因(AtCBF1)对大蕉抗寒性的影响,为从大蕉克隆抗寒相关基因奠定基础.[方法]采用农杆菌介导法转化东莞大蕉的胚性细胞悬浮系,获得转AtCBF1基因的大蕉植株;利用GUS组织染色、PCR、RT-PCR以及RT-qPCR对转基因植株进行鉴定;比较低温处理后的转基因株系和对照的冷害特征以及超氧化物歧化酶( SOD)活性和丙二醛(MDA)含量等生理生化指标,鉴定转基因大蕉植株的抗寒能力.[结果]试验共获得6个抗性再生转化系.GUS组织染色结果表明,除T1外,其余均为阳性;PCR鉴定结果表明,AtCBF1在6个抗性再生转化系均为阳性,而GUS基因在T1转化系中没有检测出;RT-PCR结果表明,AtCBF1在6个转化系均得到表达,对T1、T2和T3 3个转化系进行RT-qPCR检测发现,AtCBF1基因在3个转基因株系表达水平存在差异;在低温处理下,转基因植株的叶片相对电导率、MDA的累积都低于非转基因植株,而SOD总活性高于对照;低温处理条件下,转基因植株叶片的冷害症状明显轻于对照.[结论]At CBF1在大蕉中超表达,具有增强大蕉SOD活性,降低因低温导致的MDA含量和离子渗漏率,缓解质膜过氧程度,进而改善大蕉植株抗低温胁迫的能力.%[Objective] To elucidate the effects of over-expression of AtCBFl gene on tolerance to low-temperature in Musa ABB cv. Dongguandajiao and establish a foundation for cloning cold resistance relative genes from Dongguandajiao. [Method! Transgenic plants transformed by AtCBFl gene were generated based on Agrobacterium tumerficiens-taedizted transformation of embryogenic cell suspensions (ECS) of Dongguandajiao. The transgenic plants were confirmed via GUS staining, PCR, RT-PCR and real-time fluorescence quantitative RT-PCR(RT-qPCR). The cold tolerance of transgenic plants were evaluated by the comparisons of plant morphology and physiological parameters such as chilling injury symptom

  11. Geologic Mapping of Ascraeus Mons, Mars

    Science.gov (United States)

    Mohr, K. J.; Williams, D. A.

    2015-12-01

    Ascraeus Mons is one of the three large shield volcanoes in the Tharsis Montes province on Mars. We are conducting geologic mapping of Ascraeus in ArcMap 10.3 at 1:1,000,000 scale using a CTX dataset as a primary basemap. The CTX dataset is supplemented by HRSC, HiRISE, THEMIS, and MOLA data. Our objective is to determine the areal extent, distribution, and age relationships of different lava flow morphologies on the main flank, rift apron, and associated small-vent field of Ascraeus Mons to: (1) identify and understand changes in effusive style across the volcano, and (2) provide insight into martian magma production rates. Our mapping, thus far, at a CTX resolution (~6 m/pixel) shows a variety of effusive styles on the flanks, rift aprons, and plains on and around Ascraeus Mons. Our plan to address (1) is to create a geologic map of Ascraeus Mons. We will use this map to determine where and how different lava flows were emplaced on the flanks and surrounding plains of Ascraeus Mons. We will determine relative ages of units using the emplacement of different geological units, impacts, tectonics, and erosion via superposition relations. We will relate eruptive styles by comparing how different flows are oriented around Ascraeus Mons. Our plan for (2) is to use CTX, MOLA and HRSC datasets to determine volumes of the emplaced lava flows. The volumes will be used to calculate yield strengths and viscosities of each flow. The yield strengths and viscosities will be used to calculate magma production rates. These will prove important to better understand the history and creation of Ascraeus Mons and other volcanoes on other planetary bodies.

  12. MAPS of Cancer

    Science.gov (United States)

    Gray, Lincoln

    1998-01-01

    Our goal was to produce an interactive visualization from a mathematical model that successfully predicts metastases from head and neck cancer. We met this goal early in the project. The visualization is available for the public to view. Our work appears to fill a need for more information about this deadly disease. The idea of this project was to make an easily interpretable visualization based on what we call "functional maps" of disease. A functional map is a graphic summary of medical data, where distances between parts of the body are determined by the probability of disease, not by anatomical distances. Functional maps often beat little resemblance to anatomical maps, but they can be used to predict the spread of disease. The idea of modeling the spread of disease in an abstract multidimensional space is difficult for many people. Our goal was to make the important predictions easy to see. NASA must face this problem frequently: how to help laypersons and professionals see important trends in abstract, complex data. We took advantage of concepts perfected in NASA's graphics libraries. As an analogy, consider a functional map of early America. Suppose we choose travel times, rather than miles, as our measures of inter-city distances. For Abraham Lincoln, travel times would have been the more meaningful measure of separation between cities. In such a map New Orleans would be close to Memphis because of the Mississippi River. St. Louis would be close to Portland because of the Oregon Trail. Oklahoma City would be far from Little Rock because of the Cheyenne. Such a map would look puzzling to those of us who have always seen physical maps, but the functional map would be more useful in predicting the probabilities of inter-site transit. Continuing the analogy, we could predict the spread of social diseases such as gambling along the rivers and cattle rustling along the trails. We could simply print the functional map of America, but it would be more interesting

  13. Neural correlates of fear: insights from neuroimaging

    Directory of Open Access Journals (Sweden)

    Garfinkel SN

    2014-12-01

    Full Text Available Sarah N Garfinkel,1,2 Hugo D Critchley1,2 1Sackler Centre for Consciousness Science, 2Department of Psychiatry, Brighton and Sussex Medical School, University of Sussex, Brighton, UK Abstract: Fear anticipates a challenge to one's well-being and is a reaction to the risk of harm. The expression of fear in the individual is a constellation of physiological, behavioral, cognitive, and experiential responses. Fear indicates risk and will guide adaptive behavior, yet fear is also fundamental to the symptomatology of most psychiatric disorders. Neuroimaging studies of normal and abnormal fear in humans extend knowledge gained from animal experiments. Neuroimaging permits the empirical evaluation of theory (emotions as response tendencies, mental states, and valence and arousal dimensions, and improves our understanding of the mechanisms of how fear is controlled by both cognitive processes and bodily states. Within the human brain, fear engages a set of regions that include insula and anterior cingulate cortices, the amygdala, and dorsal brain-stem centers, such as periaqueductal gray matter. This same fear matrix is also implicated in attentional orienting, mental planning, interoceptive mapping, bodily feelings, novelty and motivational learning, behavioral prioritization, and the control of autonomic arousal. The stereotyped expression of fear can thus be viewed as a special construction from combinations of these processes. An important motivator for understanding neural fear mechanisms is the debilitating clinical expression of anxiety. Neuroimaging studies of anxiety patients highlight the role of learning and memory in pathological fear. Posttraumatic stress disorder is further distinguished by impairment in cognitive control and contextual memory. These processes ultimately need to be targeted for symptomatic recovery. Neuroscientific knowledge of fear has broader relevance to understanding human and societal behavior. As yet, only some of

  14. Theory of mind correlates with clinical insight but not cognitive insight in patients with schizophrenia.

    Science.gov (United States)

    Zhang, Qi; Li, Xu; Parker, Giverny J; Hong, Xiao-Hong; Wang, Yi; Lui, Simon S Y; Neumann, David L; Cheung, Eric F C; Shum, David H K; Chan, Raymond C K

    2016-03-30

    Research on the relationship between insight and social cognition, in particular Theory of Mind (ToM), in schizophrenia has yielded mixed findings to date. Very few studies, however, have assessed both clinical insight and cognitive insight when examining their relationships with ToM in schizophrenia. The current study thus investigated the relationship between clinical insight, cognitive insight, and ToM in a sample of 56 patients with schizophrenia and 30 healthy controls. Twenty-seven patients were classified as low in clinical insight according to their scores on the 'insight' item (G12) of the Positive and Negative Syndrome Scale (PANSS). Moreover, cognitive insight and ToM were assessed with the Beck Cognitive Insight Scale (BCIS) and the Yoni task, respectively. The results indicated that patients with poor clinical insight performed worse on tasks of second-order cognitive and affective ToM, while the ToM performance of patients with high clinical insight was equivalent to that of healthy controls. Furthermore, while clinical insight was correlated with ToM and clinical symptoms, cognitive insight did not correlate with clinical insight, ToM, or clinical symptoms. Clinical insight thus appears to be an important factor related to ToM in schizophrenia.

  15. Insight with hands and things.

    Science.gov (United States)

    Vallée-Tourangeau, Frédéric; Steffensen, Sune Vork; Vallée-Tourangeau, Gaëlle; Sirota, Miroslav

    2016-10-01

    Two experiments examined whether different task ecologies influenced insight problem solving. The 17 animals problem was employed, a pure insight problem. Its initial formulation encourages the application of a direct arithmetic solution, but its solution requires the spatial arrangement of sets involving some degree of overlap. Participants were randomly allocated to either a tablet condition where they could use a stylus and an electronic tablet to sketch a solution or a model building condition where participants were given material with which to build enclosures and figurines. In both experiments, participants were much more likely to develop a working solution in the model building condition. The difference in performance elicited by different task ecologies was unrelated to individual differences in working memory, actively open-minded thinking, or need for cognition (Experiment 1), although individual differences in creativity were correlated with problem solving success in Experiment 2. The discussion focuses on the implications of these findings for the prevailing metatheoretical commitment to methodological individualism that places the individual as the ontological locus of cognition. PMID:27569687

  16. GOES-R: Satellite Insight

    Science.gov (United States)

    Fitzpatrick, Austin J.; Leon, Nancy J.; Novati, Alexander; Lincoln, Laura K.; Fisher, Diane K.

    2012-01-01

    GOES-R: Satellite Insight seeks to bring awareness of the GOES-R (Geostationary Operational Environmental Satellite -- R Series) satellite currently in development to an audience of all ages on the emerging medium of mobile games. The iPhone app (Satellite Insight) was created for the GOES-R Program. The app describes in simple terms the types of data products that can be produced from GOES-R measurements. The game is easy to learn, yet challenging for all audiences. It includes educational content and a path to further information about GOESR, its technology, and the benefits of the data it collects. The game features action-puzzle game play in which the player must prevent an overflow of data by matching falling blocks that represent different types of GOES-R data. The game adds more different types of data blocks over time, as long as the player can prevent a data overflow condition. Points are awarded for matches, and players can compete with themselves to beat their highest score.

  17. The Insights of Algorithmic Entropy

    Directory of Open Access Journals (Sweden)

    Sean Devine

    2009-03-01

    Full Text Available The algorithmic entropy of a system, the length of the shortest algorithm that specifies the system’s exact state adds some missing pieces to the entropy jigsaw. Because the approach embodies the traditional entropies as a special case, problematic issues such as the coarse graining framework of the Gibbs’ entropy manifest themselves in a different and more manageable form, appearing as the description of the system and the choice of the universal computing machine. The provisional algorithmic entropy combines the best information about the state of the system together with any underlying uncertainty; the latter represents the Shannon entropy. The algorithmic approach also specifies structure that the traditional entropies take as given. Furthermore, algorithmic entropy provides insights into how a system can maintain itself off equilibrium, leading to Ashby’s law of requisite variety. This review shows how the algorithmic approach can provide insights into real world systems, by outlining recent work on how replicating structures that generate order can evolve to maintain a system far from equilibrium.

  18. Concept Maps Provide a Window onto Preservice Elementary Teachers' Knowledge in the Teaching and Learning of Mathematics

    Science.gov (United States)

    Chichekian, Tanya; Shore, Bruce M.

    2013-01-01

    This collaborative concept-mapping exercise was conducted in a second-year mathematics methods course. Teachers' visual representations of their mathematical content and pedagogical knowledge provided insight into their understanding of how students learn mathematics. We collected 28 preservice student teachers' concept maps and analyzed them by…

  19. Development of base maps' role in soil mapping

    Science.gov (United States)

    Miller, Brad; Brevik, Eric

    2014-05-01

    One of the ultimate goals of soil science is the production of accurate soil maps, but historically these thematic maps have relied upon base maps for positional reference and later for parameters that help predict soil properties. This presentation reviews the history of base maps and the dependence of soil mapping on them. The availability of geographic technology for producing these base maps has constrained and directed the geographic study of soil. A lack of accurate methods for determining location limited early geographic description of soils to narratives. The availability of accurate topographic maps in the late 18th century, fueled by governments' interests in documenting national boundaries and popular interest in world atlases, provided the first base maps for soil geographers. These soil maps primarily used the topographic maps as a spatial reference onto which the thematic details were drawn. Due to the late start of a systematic topographic survey in the United States, early Soil Survey maps depended upon plat maps for spatial reference. The adoption of aerial photographs in the process of soil mapping increased the role of base maps as predictive parameters. In the current geospatial revolution, global positioning systems and geographic information systems have nearly replaced the need for base maps to provide spatial reference. Today, base maps are more likely to be used as parameters in landscape models for predicting the spatial distribution of soil properties and classes. As model parameters for digital soil maps, base maps constitute the library of predictive variables and constrain the supported resolution of the soil map. This change in the relationship between base maps and the soil map is a paradigm shift that affects fundamental definitions of geography, such as scale, resolution, and detectable features. These concepts are the essential tools used to study the spatial characteristics of Earth Systems.

  20. Geologic mapping of Vesta

    Science.gov (United States)

    Yingst, R. A.; Mest, S. C.; Berman, D. C.; Garry, W. B.; Williams, D. A.; Buczkowski, D.; Jaumann, R.; Pieters, C. M.; De Sanctis, M. C.; Frigeri, A.; Le Corre, L.; Preusker, F.; Raymond, C. A.; Reddy, V.; Russell, C. T.; Roatsch, T.; Schenk, P. M.

    2014-11-01

    We report on a preliminary global geologic map of Vesta, based on data from the Dawn spacecraft's High-Altitude Mapping Orbit (HAMO) and informed by Low-Altitude Mapping Orbit (LAMO) data. This map is part of an iterative mapping effort; the geologic map has been refined with each improvement in resolution. Vesta has a heavily-cratered surface, with large craters evident in numerous locations. The south pole is dominated by an impact structure identified before Dawn's arrival. Two large impact structures have been resolved: the younger, larger Rheasilvia structure, and the older, more degraded Veneneia structure. The surface is also characterized by a system of deep, globe-girdling equatorial troughs and ridges, as well as an older system of troughs and ridges to the north. Troughs and ridges are also evident cutting across, and spiraling arcuately from, the Rheasilvia central mound. However, no volcanic features have been unequivocally identified. Vesta can be divided very broadly into three terrains: heavily-cratered terrain; ridge-and-trough terrain (equatorial and northern); and terrain associated with the Rheasilvia crater. Localized features include bright and dark material and ejecta (some defined specifically by color); lobate deposits; and mass-wasting materials. No obvious volcanic features are evident. Stratigraphy of Vesta's geologic units suggests a history in which formation of a primary crust was followed by the formation of impact craters, including Veneneia and the associated Saturnalia Fossae unit. Formation of Rheasilvia followed, along with associated structural deformation that shaped the Divalia Fossae ridge-and-trough unit at the equator. Subsequent impacts and mass wasting events subdued impact craters, rims and portions of ridge-and-trough sets, and formed slumps and landslides, especially within crater floors and along crater rims and scarps. Subsequent to the formation of Rheasilvia, discontinuous low-albedo deposits formed or were

  1. Conformal mappings and CR mappings on the Engel group

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    We show that conformal mappings between the Engel groups are CR or anti-CR mappings. This reduces the determination of conformal mappings to a problem in the theory of several complex analysis.The result about the group of CR automorphisms is used to determine the identity component of the group of conformal mappings on the Engel group.

  2. The impact of map orientation and generalisation on congestion decisions: a comparison of schematic-egocentric and topographic-allocentric maps.

    Science.gov (United States)

    Crundall, David; Crundall, Elizabeth; Burnett, Gary; Shalloe, Sally; Sharples, Sarah

    2011-08-01

    Map information for drivers is usually presented in an allocentric-topographic form (as with printed maps) or in an egocentric-schematic form (as with road signs). The advent of new variable message boards on UK motorways raises the possibility of presenting road maps to reflect congestion ahead. Should these maps be allocentric-topographic or egocentric-schematic? This was assessed in an eye tracking study, with participants viewing maps of a motorway network in order to identify whether any congestion was relevant to their intended route. The schematic-egocentric maps were responded to most accurately with shorter fixation durations suggesting easier processing. In particular, the driver's entrance and intended exit from the map were attended to more in the allocentric maps. Individual differences in mental rotation ability also seem to contribute to poor performance on allocentric maps. The results favour schematic-egocentric maps for roadside congestion information, but also provide theoretical insights into map-rotation and individual differences. Statement of Relevance: This study informs designers and policy makers about optimum representations of traffic congestion on roadside variable message signs and, furthermore, demonstrates that individual differences contribute to problems with processing certain sign types. Schematic-egocentric representations of a motorway network produced the best results, as noted in behavioural and eye movement measures.

  3. Insurance flood maps

    International Nuclear Information System (INIS)

    Dear Client, in half an hour you will be hit by a flood, please get ready. Your insurance company. Such a phone call or SMS could only mean two things: drunk friends or an insurance company using a flood map. In the second case, the best thing to do on receiving such a message is to act quickly. The advantage of flood maps do not necessarily have to start at the moment a flood becomes an immediate threat. The primary role of flood maps is to allow for a fairer calculation of insurance rates. Insurance companies can save on re-insurance costs as if the risk level is predictable re-insurance companies may offer better rates. The three largest insurance companies: Allianz - Slovenska poistovna, Kooperativa and Ceska poistovna Slovensko have begun introducing flood maps. These three companies control about 75% of the market. And if competition does not force other market participants to adopt the same approach, re-insurance companies certainly will. They will charge more for a less specifically defined risk level. So far insurance companies have not encountered this pressure, re-insurance companies are helping them set up the flood maps and in the coming years flood maps will become a common tool. Then the pressure will be there: if a insurance company uses a different calculation method, the final price may differ greatly from the competition's. If the price is higher, the company will lose clients and if the price is much lower, the risk has probably not been calculated correctly and the insurance company may suffer substantial losses in the event of a major flood. In short, the investment of several million Sk in a flood map is essential

  4. Insight of Anthropology and Writing of the History of Chinese Literature --An Interpretation on "Redrawing the Map of Chinese Literature" Advocated by Yang Yi%人类学眼光与中国文学史的书写——对杨义“重绘中国文学地图”的一种解读

    Institute of Scientific and Technical Information of China (English)

    苏永前

    2011-01-01

    In the theory and practice of "redrawing the map of Chinese literature", Yang Yi's review of the relationship between the native and the west, the periphery and the center, as well as the writing and the oral, has a rich connotation of anthropology. It is both an awareness of the defects in the studies on Chinese literature and a response to the trend of literary anthropology, which has a huge influence on the writing of the history of Chinese literature. The integrated literature concept advocated by Yang Yi makes it possible for the researches of Chinese literature to return to the native paradigm.%在“重绘中国文学地图”的命题与实践中,杨义对“本土与西方”、“边缘与中心”、“书写与口传”、“汉族文学与少数民族文学”等多重关系的重新审视,显示出丰富的人类学内涵。这既是对当下中国文学研究中诸种缺失的自觉省察,也是对方兴未艾的文学人类学思潮的一种回应,在今后的中国文学史写作中具有重要的示范意义。杨义所倡导的“大文学观”,使得中国文学研究在经历了百年“失语”之后,有了回归本土范式的可能。

  5. When higher working memory capacity hinders insight.

    Science.gov (United States)

    DeCaro, Marci S; Van Stockum, Charles A; Wieth, Mareike B

    2016-01-01

    Higher working memory capacity (WMC) improves performance on a range of cognitive and academic tasks. However, a greater ability to control attention sometimes leads individuals with higher WMC to persist in using complex, attention-demanding approaches that are suboptimal for a given task. We examined whether higher WMC would hinder insight problem solving, which is thought to rely on associative processes that operate largely outside of close attentional control. In addition, we examined whether characteristics of the insight problems influence whether this negative relationship will be revealed. In Experiment 1, participants completed matchstick arithmetic problems, which require a similar initial problem representation for all problems. Higher WMC was associated with less accurate insight problem solving. In Experiment 2, participants completed insight word problems, which require substantially different representations for each problem. Higher WMC was again negatively associated with insight, but only after statistically controlling for shared variance between insight and incremental problem-solving accuracy. These findings suggest that WMC may benefit performance on fundamental processes common to both incremental and insight problem solving (e.g., initial problem representation), but hinder performance on the processes that are unique to insight (e.g., solution and restructuring). By considering the WMC of the individual, and the nature of the insight task, we may better understand the process of insight and how to best support it. (PsycINFO Database Record PMID:26120772

  6. Evolution of mammalian genome organization inferred from comparative gene mapping

    Science.gov (United States)

    Murphy, William J; Stanyon, Roscoe; O'Brien, Stephen J

    2001-01-01

    Comparative genome analyses, including chromosome painting in over 40 diverse mammalian species, ordered gene maps from several representatives of different mammalian and vertebrate orders, and large-scale sequencing of the human and mouse genomes are beginning to provide insight into the rates and patterns of chromosomal evolution on a whole-genome scale, as well as into the forces that have sculpted the genomes of extant mammalian species. PMID:11423011

  7. Mapping the Surface Composition of Venus in the Near Infrared

    OpenAIRE

    Helbert, J.; Müller, N.; Ferrari, Sabrina; Dyar, M.D.; Smrekar, S. E.; Head, J.W.; Elkins-Tanton, L.T.

    2014-01-01

    Observing the surface of Venus in the near-infrared from orbit or from an aerial platform will provide new insights into the mineralogy of Venus. In combination with a high-resolution radar mapper that provides accurate topographic data, this would allow global or regional mapping of the surface composition at a spatial scale of approximately 50km. In addition to the high scientific value of this data in itself, VEM will also provide important constraints for future landing site selections. T...

  8. Quaternion maps of global protein structure.

    Science.gov (United States)

    Hanson, Andrew J; Thakur, Sidharth

    2012-09-01

    The geometric structures of proteins are vital to the understanding of biochemical interactions. However, there is much yet to be understood about the spatial arrangements of the chains of amino acids making up any given protein. In particular, while conventional analysis tools like the Ramachandran plot supply some insight into the local relative orientation of pairs of amino acid residues, they provide little information about the global relative orientations of large groups of residues. We apply quaternion maps to families of coordinate frames defined naturally by amino acid residue structures as a way to expose global spatial relationships among residues within proteins. The resulting visualizations enable comparisons of absolute orientations as well as relative orientations, and thus generalize the framework of the Ramachandran plot. There are a variety of possible quaternion frames and visual representation strategies that can be chosen, and very complex quaternion maps can result. Just as Ramachandran plots are useful for addressing particular questions and not others, quaternion tools have characteristic domains of relevance. In particular, quaternion maps show great potential for answering specific questions about global residue alignment in crystallographic data and statistical orientation properties in Nuclear Magnetic Resonance (NMR) data that are very difficult to treat by other methods. PMID:23099777

  9. Mapping prehistoric ghosts in the synchrotron

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, N.P.; Wogelius, R.A. [University of Manchester, School of Earth, Atmospheric, and Environmental Sciences, Manchester (United Kingdom); University of Manchester, Williamson Research Centre for Molecular Environmental Science, Manchester (United Kingdom); Bergmann, U. [SLAC National Accelerator Laboratory, Linac Coherent Light Source, Menlo Park, CA (United States); Larson, P. [Black Hills Institute of Geological Research, Inc., Hill City, SD (United States); Sellers, W.I. [University of Manchester, Faculty of Life Sciences, Manchester (United Kingdom); Manning, P.L. [University of Manchester, School of Earth, Atmospheric, and Environmental Sciences, Manchester (United Kingdom); University of Manchester, Williamson Research Centre for Molecular Environmental Science, Manchester (United Kingdom); University of Pennsylvania, Department of Earth and Environmental Science, Philadelphia, PA (United States)

    2013-04-15

    The detailed chemical analysis of fossils has the potential to reveal great insight to the composition, preservation and biochemistry of ancient life. Such analyses would ideally identify, quantify, and spatially resolve the chemical composition of preserved bone and soft tissue structures, but also the embedding matrix. Mapping the chemistry of a fossil in situ can place constraints on mass transfer between the enclosing matrix and the preserved organism(s), and therefore aid in distinguishing taphonomic processes from original chemical zonation remnant within the fossils themselves. Conventional analytical methods, such as scanning electron microscopy (SEM) and pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) have serious limitations in this case, primarily, an inability to provide large (i.e., decimeter) scale chemical maps. Additionally, vacuum chamber size and the need for destructive sampling preclude analysis of large and precious fossil specimens. However, the recent development of Synchrotron Rapid Scanning X-ray Fluorescence (SRS-XRF) at the Stanford Synchrotron Radiation Lightsource (SSRL) allows the non-destructive chemical analysis and imaging of major, minor, and trace element concentrations of large paleontological and archeological specimens in rapid scanning times. Here we present elemental maps of a fossil reptile produced using the new SRS-XRF method. Our results unequivocally show that preserved biological structures are not simply impressions or carbonized remains, but possess a remnant of the original organismal biochemistry. We show that SRS-XRF is a powerful new tool for the study of paleontological and archaeological samples. (orig.)

  10. Web Interactive Campus Map

    Directory of Open Access Journals (Sweden)

    Marylene S. Eder

    2015-03-01

    Full Text Available Abstract Interactive campus map is a web based application that can be accessed through a web browser. With the Google Map Application Programming Interface availability of the overlay function has been taken advantage to create custom map functionalities. Collection of building points were gathered for routing and to create polygons which serves as a representation of each building. The previous campus map provides a static visual representation of the campus. It uses legends building name and its corresponding building number in providing information. Due to its limited capabilities it became a realization to the researchers to create an interactive campus map.Storing data about the building room and staff information and university events and campus guide are among the primary features that this study has to offer. Interactive Web-based Campus Information System is intended in providing a Campus Information System.It is open to constant updates user-friendly for both trained and untrained users and capable of responding to all needs of users and carrying out analyses. Based on the data gathered through questionnaires researchers analyzed the results of the test survey and proved that the system is user friendly deliver information to users and the important features that the students expect.

  11. Sri Lanka Malaria Maps

    Directory of Open Access Journals (Sweden)

    van der Hoek Wim

    2003-07-01

    Full Text Available Abstract Background Despite a relatively good national case reporting system in Sri Lanka, detailed maps of malaria distribution have not been publicly available. Methods In this study, monthly records over the period 1995 – 2000 of microscopically confirmed malaria parasite positive blood film readings, at sub-district spatial resolution, were used to produce maps of malaria distribution across the island. Also, annual malaria trends at district resolution were displayed for the period 1995 – 2002. Results The maps show that Plasmodium vivax malaria incidence has a marked variation in distribution over the island. The incidence of Plasmodium falciparum malaria follows a similar spatial pattern but is generally much lower than that of P. vivax. In the north, malaria shows one seasonal peak in the beginning of the year, whereas towards the south a second peak around June is more pronounced. Conclusion This paper provides the first publicly available maps of both P. vivax and P. falciparum malaria incidence distribution on the island of Sri Lanka at sub-district resolution, which may be useful to health professionals, travellers and travel medicine professionals in their assessment of malaria risk in Sri Lanka. As incidence of malaria changes over time, regular updates of these maps are necessary.

  12. Mapping sequences by parts

    Directory of Open Access Journals (Sweden)

    Guziolowski Carito

    2007-09-01

    Full Text Available Abstract Background: We present the N-map method, a pairwise and asymmetrical approach which allows us to compare sequences by taking into account evolutionary events that produce shuffled, reversed or repeated elements. Basically, the optimal N-map of a sequence s over a sequence t is the best way of partitioning the first sequence into N parts and placing them, possibly complementary reversed, over the second sequence in order to maximize the sum of their gapless alignment scores. Results: We introduce an algorithm computing an optimal N-map with time complexity O (|s| × |t| × N using O (|s| × |t| × N memory space. Among all the numbers of parts taken in a reasonable range, we select the value N for which the optimal N-map has the most significant score. To evaluate this significance, we study the empirical distributions of the scores of optimal N-maps and show that they can be approximated by normal distributions with a reasonable accuracy. We test the functionality of the approach over random sequences on which we apply artificial evolutionary events. Practical Application: The method is illustrated with four case studies of pairs of sequences involving non-standard evolutionary events.

  13. Maps, immersions and permutations

    CERN Document Server

    Coquereaux, Robert

    2015-01-01

    We consider the problem of counting and of listing topologically inequivalent "planar" {4-valent} maps with a single component and a given number n of vertices. This enables us to count and to tabulate immersions of a circle in a sphere (spherical curves), extending results by Arnold and followers. Different options where the circle and/or the sphere are/is oriented are considered in turn, following Arnold's classification of the different types of symmetries. We also consider the case of bicolourable and bicoloured maps or immersions, where faces are bicoloured. Our method extends to immersions of a circle in a higher genus Riemann surface. There the bicolourability is no longer automatic and has to be assumed. We thus have two separate countings in non zero genus, that of bicolourable maps and that of general maps. We use a classical method of encoding maps in terms of permutations, on which the constraints of "one-componentness" and of a given genus may be applied. Depending on the orientation issue and on...

  14. Managing complexity insights, concepts, applications

    CERN Document Server

    Helbing, Dirk

    2007-01-01

    Each chapter in Managing Complexity focuses on analyzing real-world complex systems and transferring knowledge from the complex-systems sciences to applications in business, industry and society. The interdisciplinary contributions range from markets and production through logistics, traffic control, and critical infrastructures, up to network design, information systems, social conflicts and building consensus. They serve to raise readers' awareness concerning the often counter-intuitive behavior of complex systems and to help them integrate insights gained in complexity research into everyday planning, decision making, strategic optimization, and policy. Intended for a broad readership, the contributions have been kept largely non-technical and address a general, scientifically literate audience involved in corporate, academic, and public institutions.

  15. Using KML for Thematic Mapping

    Science.gov (United States)

    Sandvik, B.

    2008-12-01

    Thematic mapping has a long history in cartography, but the new geobrowsers tend not to focus on this aspect of geographical information representation. This talk demonstrates how Keyhole Markup Language (KML) and geobrowsers can be used for thematic mapping. Due to their huge public interest and relative accessibility, geobrowsers are potentially capable of bringing thematic maps or visualisations to a wider audience. KML is not targeted towards thematic mapping, but it is possible to use KML elements in ways that were probably not intended. Current possibilities for making proportional symbol maps, chart maps, choropleth maps and animated maps with KML will be presented. An open source Thematic Mapping Engine (TME) has been developed as a proof-of-concept. This application allows the user to make thematic maps through an easy-to-use web interface. TME provides a low-cost solution suitable for non-profits and public- benefit organisations.

  16. The World Stress Map

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Knowledge of the stress field in the Earth's crust is a key issue for the understanding of geodynamic processes,seismic hazard assessment, and stability of underground openings such as waste disposals, tunnels, mines or wells, and reservoir management. The World Stress Map project is a collaborative project of academia,industry and governmental organizations that aims to understand the states and sources of tectonic stresses in the Earth's crust. We present the Worm Stress Map at 1:46,000,000 scale as a result of more than two decades of international collaboration. The map reveals that the first-order pattern of stress is of plate-wide scale, indicating that plate boundary forces are the major control of the stress orientations and the tectonic regime.

  17. Insight, distress and coping styles in schizophrenia

    OpenAIRE

    Cooke, Michael; Peters, Emmanuelle; Fannon, Dominic; Anilkumar, Anantha P.P.; Aasen, Ingrid; Kuipers, Elizabeth; Kumari, Veena

    2007-01-01

    Background The stigma and negative societal views attached to schizophrenia can make the diagnosis distressing. There is evidence that poor insight into symptoms of the disorder and need for treatment may reflect the use of denial as a coping style. However, the relationships between insight and other coping styles have seldom been investigated. Method We examined the associations between insight, distress and a number of coping styles in 65 outpatients with schizophrenia (final n = 57) in a ...

  18. Investigation of insight with magic tricks

    OpenAIRE

    Faber, Amory

    2012-01-01

    This thesis proposes a new approach to investigate insight problem solving. Introducing magic tricks as a problem solving task, we asked participants to find out the secret method used by the magician to create the magic effect. Based on the theoretical framework of the representational change theory, we argue that magic tricks are ideally suited to investigate insight because similar to established insight tasks like puzzles, observers’ prior knowledge activates constraints. In order to see ...

  19. Course of insight in manic episode

    OpenAIRE

    Kumar, A; Kumar, S; N M Khan; Mishra, S.

    2013-01-01

    Background: Insight is an important factor associated with non compliance and poor outcome. Poor level of insight has been described as a characteristic in patients with acute bipolar disorder with more unawareness in social consequences with increasing severity in manic episode. Aim: Main aim of study was to see the baseline and longitudinal relationship between dimensions of insight with improvement in psychopathology. Setting and Design: Forty four patients diagnosed with mania, were selec...

  20. Map usage in virtual environments

    OpenAIRE

    Cevik, Helsin

    1998-01-01

    Approved for public release; distribution is unlimited. It is neither practical nor efficient to represent virtual maps as we do for paper maps in the real world due to major differences in hardware and software capabilities and requirements. Instead, we can determine the parameters that affect virtual map representation and that help to construct a mental map, and then manipulate these parameters in order to increase the effectiveness of map representation as an aid in performing navigati...

  1. Mapping Atrial Fibrillation: 2015 Update

    OpenAIRE

    Chirag R. Barbhayia; Saurabh Kumar; Gregory F. Michaud

    2015-01-01

    Atrial fibrillation requires a trigger that initiates the arrhythmia and substrate that favors perpetuation. Cardiac mapping is necessary to locate triggers and substrate so that an ablation strategy can be optimized. The most commonly used cardiac mapping approach is isochronal or activation mapping, which aims to create a spatial model of electrical wavefront propagation. Historically, activation mapping has been successful for mapping point source and single or double wave reentrant arr...

  2. Ergodicity of polygonal slap maps

    Science.gov (United States)

    Del Magno, Gianluigi; Lopes Dias, João; Duarte, Pedro; Gaivão, José Pedro

    2014-08-01

    Polygonal slap maps are piecewise affine expanding maps of the interval obtained by projecting the sides of a polygon along their normals onto the perimeter of the polygon. These maps arise in the study of polygonal billiards with non-specular reflection laws. We study the absolutely continuous invariant probabilities (acips) of the slap maps for several polygons, including regular polygons and triangles. We also present a general method for constructing polygons with slap maps with more than one ergodic acip.

  3. Mapping your competitive position.

    Science.gov (United States)

    D'Aveni, Richard A

    2007-11-01

    A price-benefit positioning map helps you see, through your customers' eyes, how your product compares with all its competitors in a market. You can draw such a map quickly and objectively, without having to resort to costly, time-consuming consumer surveys or subjective estimates of the excellence of your product and the shortcomings of all the others. Creating a positioning map involves three steps: First, define your market to include everything your customers might consider to be your product's competitors or substitutes. Second, track the price your customers actually pay (wholesale or retail? bundled or unbundled?) and identify what your customers see as your offering's primary benefit. This is done through regression analysis, determining which of the product's attributes (as described objectively by rating services, government agencies, R&D departments, and the like) explains most of the variance in its price. Third, draw the map by plotting on a graph the position of every product in the market you've selected according to its price and its level of primary benefit, and draw a line that runs through the middle of the points. What you get is a picture of the competitive landscape of your market, where all the products above the line command a price premium owing to some secondary benefit customers value, and all those below the line are positioned to earn market share through lower prices and reduced secondary benefits. Using examples as varied as Harley-Davidson motorcycles, Motorola cell phones, and the New York restaurant market, Tuck professor D'Aveni demonstrates some of the many ways the maps can be used: to locate unoccupied or less-crowded spaces in highly competitive markets, for instance, or to identify opportunities created through changes in the relationship between the primary benefit and prices. The maps even allow companies to anticipate--and counter-- rivals' strategies. R eprint RO711G PMID:18159791

  4. Mapping the Frozen Void

    Science.gov (United States)

    Suutarinen, Aleksi; Fraser, Helen

    2013-07-01

    Reactions on the surfaces of dust grains play a vital role in the overall chemistry of interstellar matter. These grains become covered by icy layers, which are the largest molecular reservoir in the interstellar medium. Given this, it is surprising that the effect ice has on the overall chain of reactions is poorly characterized. One step on the path of gaining better understanding here is to develop methods of figuring out how much ice is present in these clouds, the links between ice components, and synergy between the ices and gas phase molecules. We do this by examining the absorption spectra of ices on lines of sight towards several stars behind clouds of interstellar matter. From these we can reconstruct spatial maps of the ice distribution on scales of as little as 1000 AU, as a test of the chemical variation within a cloud. By overlapping the ice data with other maps of the same region (gas emission, temperature, density etc) we create combined maps to reveal the astrochemistry of star-forming regions and pre-stellar cores. In this poster we present the continuing results of our ice mapping programme, using data from the AKARI satellite, specifically in slitless spectroscopy observations in the NIR. In this region the key ice features encompass H2O, CO and CO2. The maps illustrate the power of our dedicated AKARI data reduction pipeline, and the novelty of our observing programme. We also detail the next steps' in our ice mapping research. The method is being expanded to include the full 10'x10' AKARI field of view, taking account of image distortion induced by the dispersing optics. These maps are then combined with exiting gas-phase observations and SCUBA maps. The latest attempts at this are shown here. What is clear already is that it is difficult to predict ice abundances from factors such as extinction or gas density alone, and that ice formation and evolution can vary hugely over even very small astronomical scales.

  5. On occult period maps

    CERN Document Server

    Kudla, Stephen

    2012-01-01

    We consider the "occult" period maps into ball quotients which exist for the moduli spaces of cubic surfaces, cubic threefolds, non-hyperelliptic curves of genus three and four. These were constructed in the work of Allcock/Carlson/Toledo, Looijenga/Swierstra, and Kondo. We interpret these maps as morphisms into moduli spaces of polarized abelian varieties of Picard type, and show that these morphisms, whose initial construction is transcendental, are defined over the natural field of definition of the spaces involved. This paper is extracted from section 15 of our paper arXiv:0912.3758, and differs from it only in some points of exposition.

  6. Learning Bing maps API

    CERN Document Server

    Sinani, Artan

    2013-01-01

    This is a practical, hands-on guide with illustrative examples, which will help you explore the vast universe of Bing maps.If you are a developer who wants to learn how to exploit the numerous features of Bing Maps then this book is ideal for you. It can also be useful for more experienced developers who wish to explore other areas of the APIs. It is assumed that you have some knowledge of JavaScript, HTML, and CSS. For some chapters a working knowledge of .Net and Visual Studio is also needed.

  7. Computer vision mapping system

    International Nuclear Information System (INIS)

    This paper describes a system capable of accurately mapping the pipe layout (including the associated components) in an existing nuclear power plant. The system processes the images taken by a laser range finder and creates a 3D model of the existing pipe system. Accurate mapping of the geometry, location, and orientation of pipe routes as well as components will permit both the generation of the 3D CAD database and validation of as-built plants with pre-existing CAD databases. (author)

  8. Resting state functional connectivity in perfusion imaging: correlation maps with BOLD connectivity and resting state perfusion.

    Directory of Open Access Journals (Sweden)

    Roberto Viviani

    Full Text Available Functional connectivity is a property of the resting state that may provide biomarkers of brain function and individual differences. Classically, connectivity is estimated as the temporal correlation of spontaneous fluctuations of BOLD signal. We investigated differences in connectivity estimated from the BOLD and CBF signal present in volumes acquired with arterial spin labeling technique in a large sample (N = 265 of healthy individuals. Positive connectivity was observable in both BOLD and CBF signal, and was present in the CBF signal also at frequencies lower than 0.009 Hz, here investigated for the first time. Negative connectivity was more variable. The validity of positive connectivity was confirmed by the existence of correlation across individuals in its intensity estimated from the BOLD and CBF signal. In contrast, there was little or no correlation across individuals between intensity of connectivity and mean perfusion levels, suggesting that these two biomarkers correspond to distinct sources of individual differences.

  9. Some Combined Relations between Contractive Mappings, Kannan Mappings, Reasonable Expansive Mappings, and -Stability

    Directory of Open Access Journals (Sweden)

    De la Sen M

    2009-01-01

    Full Text Available In recent literature concerning fixed point theory for self-mappings in metric spaces , there are some new concepts which can be mutually related so that the inherent properties of each one might be combined for such self-mappings. Self-mappings can be referred to, for instance, as Kannan-mappings, reasonable expansive mappings, and Picard -stable mappings. Some relations between such concepts subject either to sufficient, necessary, or necessary and sufficient conditions are obtained so that in certain self-mappings can exhibit combined properties being inherent to each of its various characterizations.

  10. eMAPS

    CERN Multimedia

    Human Resources Department

    2005-01-01

    Starting with the 2005 performance appraisal and advancement exercise (MAPS), the paper version of the annual appraisal report has been replaced by an electronic EDH version - eMAPS (see Weekly Bulletin 48/2004). As announced in Weekly Bulletin 2/2005, information sessions to explain the features of eMAPS using EDH have been arranged as follows: 18 January 2005: Main Auditorium (500-1-001) from 14:00 to 15:30. 20 January 2005: AB Auditorium II (864-1-D02) from 14:00 to 15:30. 24 January 2005: AT Auditorium (30-7-018) from 10:00 to 11:30. The changeover to an electronic appraisal report is designed to reduce the administrative workload involving, e.g. photocopying, tracing and filing paper copies, while allowing staff members and their hierarchy access to the report form at the appropriate times. There is no change in the procedure for the annual interview and the advancement exercise, though Administrative Circular No 26 (Rev. 5) has been updated to take account of the introduction of eMAPS. The content...

  11. STOCHASTIC FLOWS OF MAPPINGS

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In this paper, the stochastic flow of mappings generated by a Feller convolution semigroup on a compact metric space is studied. This kind of flow is the generalization of superprocesses of stochastic flows and stochastic diffeomorphism induced by the strong solutions of stochastic differential equations.

  12. Bisimulation from Open Maps

    DEFF Research Database (Denmark)

    Joyal, André; Nielsen, Mogens; Winskel, Glynn

    1996-01-01

    and van Glabeek and Goltz. A tie-up with open maps in a (pre)topos, as they appear in the work of Joyal and Moerdijk, brings to light a new model, presheaves on categories of pomsets, into which the usual category of labelled event structures embeds fully and faithfully. As an indication of its promise...

  13. Bisimulation and open maps

    DEFF Research Database (Denmark)

    Joyal, André; Nielsen, Mogens; Winskel, Glynn

    1993-01-01

    ), and Goltz and van Glabeek (1989). A tie-up with open maps in a (pre)topos brings to light a promising new model, presheaves on categories of pomsets, into which the usual category of labeled event structures embeds fully and faithfully. As an indication of its promise, this new presheaf model has refinement...

  14. Mapping the Field

    DEFF Research Database (Denmark)

    Goerres, Achim; Vanhuysse, Pieter

    2012-01-01

    Whereas the call for a political science based study of older people and ageing is not new (Cutler 1977; Heclo 1988), relatively little unified progress has been made so far. This chapter maps the field of generational politics and introduces our edited volume "Ageing Populations in Post-Industri...

  15. Learning maps -- Application

    International Nuclear Information System (INIS)

    The paper consists of a series of slides used in the presentation. They summarize the Root Learning Map process which is a tool that allows a company to modify its culture to improve productivity by allowing employees to have a vested interest in the outcome of the company. Educating the employees about different aspects of the organization is a major part of the process

  16. "Total Deposition (TDEP) Maps"

    Science.gov (United States)

    The presentation provides an update on the use of a hybrid methodology that relies on measured values from national monitoring networks and modeled values from CMAQ to produce of maps of total deposition for use in critical loads and other ecological assessments. Additionally, c...

  17. Personal Food System Mapping

    Science.gov (United States)

    Wilsey, David; Dover, Sally

    2014-01-01

    Personal food system mapping is a practical means to engage community participants and educators in individualized and shared learning about food systems, decisions, and behaviors. Moreover, it is a useful approach for introducing the food system concept, which is somewhat abstract. We developed the approach to capture diversity of personal food…

  18. Bipartite depolarizing maps

    Science.gov (United States)

    Lami, Ludovico; Huber, Marcus

    2016-09-01

    We introduce a 3-parameter class of maps (1) acting on a bipartite system which are a natural generalisation of the depolarizing channel (and include it as a special case). Then, we find the exact regions of the parameter space that alternatively determine a positive, completely positive, entanglement-breaking, or entanglement-annihilating map. This model displays a much richer behaviour than the one shown by a simple depolarizing channel, yet it stays exactly solvable. As an example of this richness, positive partial transposition but not entanglement-breaking maps is found in Theorem 2. A simple example of a positive yet indecomposable map is provided (see the Remark at the end of Section IV). The study of the entanglement-annihilating property is fully addressed by Theorem 7. Finally, we apply our results to solve the problem of the entanglement annihilation caused in a bipartite system by a tensor product of local depolarizing channels. In this context, a conjecture posed in the work of Filippov [J. Russ. Laser Res. 35, 484 (2014)] is affirmatively answered, and the gaps that the imperfect bounds of Filippov and Ziman [Phys. Rev. A 88, 032316 (2013)] left open are closed. To arrive at this result, we furthermore show how the Hadamard product between quantum states can be implemented via local operations.

  19. SS05 - Mind Mapping

    OpenAIRE

    Rachman, Alwy; Rapi, Amrin

    2011-01-01

    Dunia kampus adalah dunia akademis. Dunia akademis adalah dunia gagasan (dunia ide) yang terhubung dengan ilmu pengetahuan. Menjadi mahasiswa baru ibarat memasuki tahap awal dari satu dunia sebagaimana di atas, sebuah dunia yang sarat dengan informasi dari berbagai disiplin pengetahuan. Oleh karenanya, memetakan pikiran dan gagasan (mind mapping) adalah keterampilan yang diperlukan bagi siapa saja yang berhubungan dengan dunia pikiran dan gagasan.

  20. Between Maps and Territories

    DEFF Research Database (Denmark)

    Holmboe, Rasmus; Stricker, Jan Høgh

    2016-01-01

    This audio paper departs from an artwork made by Andreas Führer called The Map is Not The Territory D’Or; a score for a soundwalk in the town of Roskilde, Denmark. The basic sound materials used in the audio paper are 1) an interview in Danish with the artist, 2) a voice over of a theoretical tex...

  1. Mapping Joint Action.

    Science.gov (United States)

    Slawski, Carl

    The flow diagrams in this document provide cognitive maps to aid in synthesizing diverse areas of knowledge in a special brand of field theory. A model is presented which highlights the domains of structural functionalism (with concepts of cultural, personal and societal systems) and symbolic interactionism (with the concepts of self, sentiments…

  2. Mapping Global Citizenship

    Science.gov (United States)

    Stein, Sharon

    2015-01-01

    The demand to cultivate global citizenship is frequently invoked as central to colleges' and universities' internationalization efforts. However, the term "global citizenship" remains undertheorized in the context of U.S. higher education. This article maps and engages three common global citizenship positions--entrepreneurial, liberal…

  3. Map of the Moon

    Institute of Scientific and Technical Information of China (English)

    TANG YUANKAI

    2010-01-01

    @@ China has finished the full map of the Moon based on data obtained by its lunar probe Chang'e l,said Ouyang Ziyuan,chief scientist of China's lunar exploration program and an academician at the Chinese Academy of Sciences(CAS),at a press conference about the scientific achievements made by Chang'e1 on July 16,2010.

  4. Mapping digital media: Netherlands

    NARCIS (Netherlands)

    M. de Waal; A. Leurdijk; L. Nordeman; T. Poell

    2012-01-01

    The Mapping Digital Media project examines the global opportunities and risks created by the transition from traditional to digital media. Covering 60 countries, the project examines how these changes affect the core democratic service that any media system should provide: news about political, econ

  5. Mapping the Literature

    DEFF Research Database (Denmark)

    Boulus-Rødje, Nina

    2012-01-01

    As the utilization of various e-voting technologies has notably increased in the past few years, so has the amount of publications on experiences with these technologies. This article, will, therefore map the literature while highlighting some of the important topics discussed within the field of e...

  6. Secured Ontology Mapping

    Directory of Open Access Journals (Sweden)

    Manjula Shenoy.K

    2012-11-01

    Full Text Available Today’s market evolution and high volatility of business requirements put an increasing emphasis on theability for systems to accommodate the changes required by new organizational needs while maintainingsecurity objectives satisfiability. This is all the more true in case of collaboration and interoperabilitybetween different organizations and thus between their information systems. Ontology mapping has beenused for interoperability and several mapping systems have evolved to support the same. Usual solutionsdo not take care of security. That is almost all systems do a mapping of ontologies which are unsecured.We have developed a system for mapping secured ontologies using graph similarity concept. Here we giveno importance to the strings that describe ontology concepts ,properties etc. Because these strings may beencrypted in the secured ontology. Instead we use the pure graphical structure to determine mappingbetween various concepts of given two secured ontologies. The paper also gives the measure of accuracyof experiment in a tabular form in terms of precision, recall and F-measure.

  7. Photogrammetry and Digital Mapping

    DEFF Research Database (Denmark)

    Frederiksen, Poul

    1998-01-01

    Technical tour to Lithuania, Poland and Estonia for 13 technical staff and managers of State Land Service, HQ, Latvia. Focus on technical aspects and management of geographical data for map production and administration. Visits to state and local government organisations and newly established...

  8. Covariance mapping techniques

    Science.gov (United States)

    Frasinski, Leszek J.

    2016-08-01

    Recent technological advances in the generation of intense femtosecond pulses have made covariance mapping an attractive analytical technique. The laser pulses available are so intense that often thousands of ionisation and Coulomb explosion events will occur within each pulse. To understand the physics of these processes the photoelectrons and photoions need to be correlated, and covariance mapping is well suited for operating at the high counting rates of these laser sources. Partial covariance is particularly useful in experiments with x-ray free electron lasers, because it is capable of suppressing pulse fluctuation effects. A variety of covariance mapping methods is described: simple, partial (single- and multi-parameter), sliced, contingent and multi-dimensional. The relationship to coincidence techniques is discussed. Covariance mapping has been used in many areas of science and technology: inner-shell excitation and Auger decay, multiphoton and multielectron ionisation, time-of-flight and angle-resolved spectrometry, infrared spectroscopy, nuclear magnetic resonance imaging, stimulated Raman scattering, directional gamma ray sensing, welding diagnostics and brain connectivity studies (connectomics). This review gives practical advice for implementing the technique and interpreting the results, including its limitations and instrumental constraints. It also summarises recent theoretical studies, highlights unsolved problems and outlines a personal view on the most promising research directions.

  9. 2004 Alaska Lidar Mapping

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The data sets are generated using the OPTECH ALTM 70 kHz LIDAR system mounted onboard AeroMap's twin-engine Cessna 320 aircraft. Classified data sets such as this...

  10. Comparative wear mapping techniques

    DEFF Research Database (Denmark)

    Alcock, J.; Sørensen, Ole Toft; Jensen, S.;

    1996-01-01

    Pin surfaces were analysed by laser profilometry. Two roughness parameters, R(a) and the fractal dimension, were investigated as a first step towards methods of quantitative wear mechanism mapping. Both parameters were analysed for their relationship to the severity and prevalence of a mechanism....

  11. Comparative wear mapping techniques

    DEFF Research Database (Denmark)

    Alcock, J.; Sørensen, Ole Toft; Jensen, S.;

    1996-01-01

    Pin-on-disc tests of tungsten carbide pins against silicon carbide discs were performed and wear rate, mechanism and friction maps constructed. Correlations were observed between the wear mode and the friction of the pin-disc interface, and between the qualitative incidence of disruptive wear...

  12. A consensus linkage map of the grass carp (Ctenopharyngodon idella based on microsatellites and SNPs

    Directory of Open Access Journals (Sweden)

    Li Jiale

    2010-02-01

    Full Text Available Abstract Background Grass carp (Ctenopharyngodon idella belongs to the family Cyprinidae which includes more than 2000 fish species. It is one of the most important freshwater food fish species in world aquaculture. A linkage map is an essential framework for mapping traits of interest and is often the first step towards understanding genome evolution. The aim of this study is to construct a first generation genetic map of grass carp using microsatellites and SNPs to generate a new resource for mapping QTL for economically important traits and to conduct a comparative mapping analysis to shed new insights into the evolution of fish genomes. Results We constructed a first generation linkage map of grass carp with a mapping panel containing two F1 families including 192 progenies. Sixteen SNPs in genes and 263 microsatellite markers were mapped to twenty-four linkage groups (LGs. The number of LGs was corresponding to the haploid chromosome number of grass carp. The sex-specific map was 1149.4 and 888.8 cM long in females and males respectively whereas the sex-averaged map spanned 1176.1 cM. The average resolution of the map was 4.2 cM/locus. BLAST searches of sequences of mapped markers of grass carp against the whole genome sequence of zebrafish revealed substantial macrosynteny relationship and extensive colinearity of markers between grass carp and zebrafish. Conclusions The linkage map of grass carp presented here is the first linkage map of a food fish species based on co-dominant markers in the family Cyprinidae. This map provides a valuable resource for mapping phenotypic variations and serves as a reference to approach comparative genomics and understand the evolution of fish genomes and could be complementary to grass carp genome sequencing project.

  13. Spatial downscaling and mapping of daily precipitation and air temperature using daily station data and monthly mean maps

    Science.gov (United States)

    Flint, A. L.; Flint, L. E.; Stern, M. A.

    2013-12-01

    values away from the station locations based on the underlying geographic structure of the monthly maps. We compare our results with the web based 12 km Variable Infiltration Capacity model (VIC) daily data and the 1 km DayMet daily data as well as make comparisons of the month summation or average of daily data sets with the PRISM and CRU data sets. There were mixed results in the comparisons with some good agreement and some bad agreement, even between VIC and DayMet. These daily maps are intended to be used as input to daily hydrological models. The results will provide more insight into the significance of the differences, at least from a hydrology perspective.

  14. First insights into disassembled "evapotranspiration"

    Science.gov (United States)

    Chormański, Jarosław; Kleniewska, Małgorzata; Berezowski, Tomasz; Szporak-Wasilewska, Sylwia; Okruszko, Tomasz; Szatyłowicz, Jan; Batelaan, Okke

    2015-04-01

    In this work we present an initial data analysis obtained from a complex tool for measuring water fluxes in wetland ecosystems. The tool was designed to quantify processes related to interception storage on plants leafs. The measurements are conducted by combining readings from various instruments, including: eddy covariance tower (EC), field spectrometer, SapFlow system, rain gauges above and under canopy, soil moisture probes and other. The idea of this set-up is to provide continuous measurement of overall water flux from the ecosystem (EC tower), intercepted water volume and timing (field spectrometers), through-fall (rain gauges above and under canopy), transpiration (SapFlow), evaporation and soil moisture (soil moisture probes). Disassembling the water flux to the above components allows giving more insight to the interception related processes and differentiates them fromthe total evapotranspiration. The measurements are conducted in the Upper Biebrza Basin (NE Poland). The study area is part of the valley and is covered by peat soils (mainly peat moss with the exception of areas near the river) and receives no inundations waters of the Biebrza. The plant community of Agrostietum-Carici caninae has a dominant share here creating an up to 0.6 km wide belt along the river. The area is covered also by Caricion lasiocarpae as well as meadows and pastures Molinio-Arrhenatheretea, Phragmitetum communis. Sedges form a hummock pattern characteristic for the sedge communities in natural river valleys with wetland vegetation. The main result of the measurement set-up will be the analyzed characteristics and dynamics of interception storage for sedge ecosystems and a developed methodology for interception monitoring by use spectral reflectance technique. This will give a new insight to processes of evapotranspiration in wetlands and its component transpiration, evaporation from interception and evaporation from soil. Moreover, other important results of this project

  15. THE EFFECTIVENESS OF PANORAMIC MAPS DESIGN: A PRELIMINARY STUDY BASED ON MOBILE EYE-TRACKING

    OpenAIRE

    Balzarini, R.; Murat, M.

    2016-01-01

    This paper presents preliminary results from an ongoing research based on the study of visual attention through mobile eye-tracking techniques. The visual-cognitive approach investigates the reading-comprehension of a particular territorial representation: ski trails maps. The general issue of the study is to provide insights about the effectiveness of panoramic ski maps and more broadly, to suggest innovative efficient representation of the geographic information in mountain. According to so...

  16. Chern-Simons expectation values and quantum horizons from loop quantum gravity and the Duflo map.

    Science.gov (United States)

    Sahlmann, Hanno; Thiemann, Thomas

    2012-03-16

    We report on a new approach to the calculation of Chern-Simons theory expectation values, using the mathematical underpinnings of loop quantum gravity, as well as the Duflo map, a quantization map for functions on Lie algebras. These new developments can be used in the quantum theory for certain types of black hole horizons, and they may offer new insights for loop quantum gravity, Chern-Simons theory and the theory of quantum groups. PMID:22540458

  17. New insights into the Plasmodium vivax transcriptome using RNA-Seq.

    OpenAIRE

    Zhu, L.; Mok, S.; Imwong, M; Jaidee, A; Russell, B.; Nosten, F.; Day, NP; White, NJ; Preiser, PR; Bozdech, Z

    2016-01-01

    Historically seen as a benign disease, it is now becoming clear that Plasmodium vivax can cause significant morbidity. Effective control strategies targeting P. vivax malaria is hindered by our limited understanding of vivax biology. Here we established the P. vivax transcriptome of the Intraerythrocytic Developmental Cycle (IDC) of two clinical isolates in high resolution by Illumina HiSeq platform. The detailed map of transcriptome generates new insights into regulatory mechanisms of indivi...

  18. Integrating Evolutionary Game Theory into Mechanistic Genotype-Phenotype Mapping.

    Science.gov (United States)

    Zhu, Xuli; Jiang, Libo; Ye, Meixia; Sun, Lidan; Gragnoli, Claudia; Wu, Rongling

    2016-05-01

    Natural selection has shaped the evolution of organisms toward optimizing their structural and functional design. However, how this universal principle can enhance genotype-phenotype mapping of quantitative traits has remained unexplored. Here we show that the integration of this principle and functional mapping through evolutionary game theory gains new insight into the genetic architecture of complex traits. By viewing phenotype formation as an evolutionary system, we formulate mathematical equations to model the ecological mechanisms that drive the interaction and coordination of its constituent components toward population dynamics and stability. Functional mapping provides a procedure for estimating the genetic parameters that specify the dynamic relationship of competition and cooperation and predicting how genes mediate the evolution of this relationship during trait formation.

  19. Integrating Evolutionary Game Theory into Mechanistic Genotype-Phenotype Mapping.

    Science.gov (United States)

    Zhu, Xuli; Jiang, Libo; Ye, Meixia; Sun, Lidan; Gragnoli, Claudia; Wu, Rongling

    2016-05-01

    Natural selection has shaped the evolution of organisms toward optimizing their structural and functional design. However, how this universal principle can enhance genotype-phenotype mapping of quantitative traits has remained unexplored. Here we show that the integration of this principle and functional mapping through evolutionary game theory gains new insight into the genetic architecture of complex traits. By viewing phenotype formation as an evolutionary system, we formulate mathematical equations to model the ecological mechanisms that drive the interaction and coordination of its constituent components toward population dynamics and stability. Functional mapping provides a procedure for estimating the genetic parameters that specify the dynamic relationship of competition and cooperation and predicting how genes mediate the evolution of this relationship during trait formation. PMID:27017185

  20. Forelimb training drives transient map reorganization in ipsilateral motor cortex.

    Science.gov (United States)

    Pruitt, David T; Schmid, Ariel N; Danaphongse, Tanya T; Flanagan, Kate E; Morrison, Robert A; Kilgard, Michael P; Rennaker, Robert L; Hays, Seth A

    2016-10-15

    Skilled motor training results in reorganization of contralateral motor cortex movement representations. The ipsilateral motor cortex is believed to play a role in skilled motor control, but little is known about how training influences reorganization of ipsilateral motor representations of the trained limb. To determine whether training results in reorganization of ipsilateral motor cortex maps, rats were trained to perform the isometric pull task, an automated motor task that requires skilled forelimb use. After either 3 or 6 months of training, intracortical microstimulation (ICMS) mapping was performed to document motor representations of the trained forelimb in the hemisphere ipsilateral to that limb. Motor training for 3 months resulted in a robust expansion of right forelimb representation in the right motor cortex, demonstrating that skilled motor training drives map plasticity ipsilateral to the trained limb. After 6 months of training, the right forelimb representation in the right motor cortex was significantly smaller than the representation observed in rats trained for 3 months and similar to untrained controls, consistent with a normalization of motor cortex maps. Forelimb map area was not correlated with performance on the trained task, suggesting that task performance is maintained despite normalization of cortical maps. This study provides new insights into how the ipsilateral cortex changes in response to skilled learning and may inform rehabilitative strategies to enhance cortical plasticity to support recovery after brain injury. PMID:27392641

  1. Analysis of Patent Databases Using VxInsight

    Energy Technology Data Exchange (ETDEWEB)

    BOYACK,KEVIN W.; WYLIE,BRIAN N.; DAVIDSON,GEORGE S.; JOHNSON,DAVID K.

    2000-12-12

    We present the application of a new knowledge visualization tool, VxInsight, to the mapping and analysis of patent databases. Patent data are mined and placed in a database, relationships between the patents are identified, primarily using the citation and classification structures, then the patents are clustered using a proprietary force-directed placement algorithm. Related patents cluster together to produce a 3-D landscape view of the tens of thousands of patents. The user can navigate the landscape by zooming into or out of regions of interest. Querying the underlying database places a colored marker on each patent matching the query. Automatically generated labels, showing landscape content, update continually upon zooming. Optionally, citation links between patents may be shown on the landscape. The combination of these features enables powerful analyses of patent databases.

  2. Understanding Spatial Genome Organization:Methods and Insights

    Institute of Scientific and Technical Information of China (English)

    Vijay Ramani; Jay Shendure; Zhijun Duan

    2016-01-01

    The manner by which eukaryotic genomes are packaged into nuclei while maintaining crucial nuclear functions remains one of the fundamental mysteries in biology. Over the last ten years, we have witnessed rapid advances in both microscopic and nucleic acid-based approaches to map genome architecture, and the application of these approaches to the dissection of higher-order chromosomal structures has yielded much new information. It is becoming increasingly clear, for example, that interphase chromosomes form stable, multilevel hierarchical structures. Among them, self-associating domains like so-called topologically associating domains (TADs) appear to be building blocks for large-scale genomic organization. This review describes features of these broadly-defined hierarchical structures, insights into the mechanisms underlying their formation, our current understanding of how interactions in the nuclear space are linked to gene regulation, and important future directions for the field.

  3. Mining Login Data for Actionable Student Insight

    Science.gov (United States)

    Agnihotri, Lalitha; Aghababyan, Ani; Mojarad, Shirin; Riedesel, Mark; Essa, Alfred

    2015-01-01

    Student login data is a key resource for gaining insight into their learning experience. However, the scale and the complexity of this data necessitate a thorough exploration to identify potential actionable insights, thus rendering it less valuable compared to student achievement data. To compensate for the underestimation of login data…

  4. Course of insight in manic episode

    Directory of Open Access Journals (Sweden)

    A Kumar

    2013-01-01

    Full Text Available Background: Insight is an important factor associated with non compliance and poor outcome. Poor level of insight has been described as a characteristic in patients with acute bipolar disorder with more unawareness in social consequences with increasing severity in manic episode. Aim: Main aim of study was to see the baseline and longitudinal relationship between dimensions of insight with improvement in psychopathology. Setting and Design: Forty four patients diagnosed with mania, were selected from an inpatient setting at Institute of Mental Health and Hospital, Agra with mean age of 31.07(±9.00 years. They were assessed at base line and were followed up weekly or psychopathology and insight. Materials and Methods: The Young′s mania rating scale for psychopathology and insight was assessed on three dimensions of SUMD. Results: Twenty five patients eventually completed the study. There was a positive correlation with global insight and with psychopathology consistent in longitudinal follow-up (P<0.05, but not correlating for awareness for achieved effect of medication and social consequences. Linear regression showed a positive relationship at the first and second week of assessment of SUMD and YMRS scores (P=0.001; 0.019. Conclusion: Improvement in insight is graded in a manic episode as compared to psychopathology. There is slower improvement in awareness of social consequences of mental disorder. It means that improvement in psychopathology may not necessarily indicate remission and need further supervision to improve insight and hence monitoring.

  5. Insight Projects: PATHway and Replay overview

    OpenAIRE

    Monaghan, David; Walsh, Deirdre; Ahmadi, Amin

    2015-01-01

    An overview of current projects within Insight presented during the Insight Summer Research Event, including PATHway: Technology enabled behavioural change as a pathway towards better self-management of CVD and RePLAY: Digitally Capturing Unique skills in European Traditional Sports and Games.

  6. Towards Responsible Steel: Preliminary Insights

    Directory of Open Access Journals (Sweden)

    Suzanne Benn

    2014-03-01

    Full Text Available This paper examines the structures and processes underpinning the attempt of the Australian steel industry to establish a certification scheme for Responsible Steel. We take it as a case example of how collective action and collaboration along a supply chain has the potential to be a win-win situation for the environment and for the competitiveness of an industry sector. The paper identifies the drivers that have prompted key stakeholders from all major sectors of the Australian steel product life cycle from mining through steel manufacturing, processing, product fabrication, use and re-use, and recycling to collaborate in the establishment of the Steel Stewardship Forum (SSF, the structure established to lead the development of the certification scheme. The development of this initiative is indicative of the wider shift to sustainability-related certification schemes as a means of garnering legitimacy and market advantage and provides detailed insights into both the drivers for and the challenges associated with such initiatives. Findings from the paper contribute to our understanding of the shift to sustainable supply chains as it is interpreted through institutional and institutional entrepreneurship theory.

  7. USGS Imagery Only Base Map Service from The National Map

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — USGS Imagery Only is a tile cache base map of orthoimagery in The National Map visible to the 1:18,000 scale. Orthoimagery data are typically high resolution images...

  8. Habitat--Offshore of Point Reyes Map Map Area, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the habitat map of the seafloor of the Offshore of Point Reyes map area, California. The vector data file is included in...

  9. Bathymetry Offshore of Point Reyes Map Map Area, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the bathymetry and shaded-relief maps of the Offshore of Point Reyes map area, California. Raster data file is included in...

  10. Bathymetry Hillshade Offshore of Point Reyes Map Map Area, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the bathymetry and shaded-relief maps of the Offshore of Point Reyes map area, California. Raster data file is included in...

  11. Contours Offshore of Point Reyes Map Map Area, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the bathymetric contours for several seafloor maps of the Offshore of Point Reyes map area, California. The vector data file...

  12. Insight: An ontology-based integrated database and analysis platform for epilepsy self-management research.

    Science.gov (United States)

    Sahoo, Satya S; Ramesh, Priya; Welter, Elisabeth; Bukach, Ashley; Valdez, Joshua; Tatsuoka, Curtis; Bamps, Yvan; Stoll, Shelley; Jobst, Barbara C; Sajatovic, Martha

    2016-10-01

    We present Insight as an integrated database and analysis platform for epilepsy self-management research as part of the national Managing Epilepsy Well Network. Insight is the only available informatics platform for accessing and analyzing integrated data from multiple epilepsy self-management research studies with several new data management features and user-friendly functionalities. The features of Insight include, (1) use of Common Data Elements defined by members of the research community and an epilepsy domain ontology for data integration and querying, (2) visualization tools to support real time exploration of data distribution across research studies, and (3) an interactive visual query interface for provenance-enabled research cohort identification. The Insight platform contains data from five completed epilepsy self-management research studies covering various categories of data, including depression, quality of life, seizure frequency, and socioeconomic information. The data represents over 400 participants with 7552 data points. The Insight data exploration and cohort identification query interface has been developed using Ruby on Rails Web technology and open source Web Ontology Language Application Programming Interface to support ontology-based reasoning. We have developed an efficient ontology management module that automatically updates the ontology mappings each time a new version of the Epilepsy and Seizure Ontology is released. The Insight platform features a Role-based Access Control module to authenticate and effectively manage user access to different research studies. User access to Insight is managed by the Managing Epilepsy Well Network database steering committee consisting of representatives of all current collaborating centers of the Managing Epilepsy Well Network. New research studies are being continuously added to the Insight database and the size as well as the unique coverage of the dataset allows investigators to conduct

  13. Insight: An ontology-based integrated database and analysis platform for epilepsy self-management research.

    Science.gov (United States)

    Sahoo, Satya S; Ramesh, Priya; Welter, Elisabeth; Bukach, Ashley; Valdez, Joshua; Tatsuoka, Curtis; Bamps, Yvan; Stoll, Shelley; Jobst, Barbara C; Sajatovic, Martha

    2016-10-01

    We present Insight as an integrated database and analysis platform for epilepsy self-management research as part of the national Managing Epilepsy Well Network. Insight is the only available informatics platform for accessing and analyzing integrated data from multiple epilepsy self-management research studies with several new data management features and user-friendly functionalities. The features of Insight include, (1) use of Common Data Elements defined by members of the research community and an epilepsy domain ontology for data integration and querying, (2) visualization tools to support real time exploration of data distribution across research studies, and (3) an interactive visual query interface for provenance-enabled research cohort identification. The Insight platform contains data from five completed epilepsy self-management research studies covering various categories of data, including depression, quality of life, seizure frequency, and socioeconomic information. The data represents over 400 participants with 7552 data points. The Insight data exploration and cohort identification query interface has been developed using Ruby on Rails Web technology and open source Web Ontology Language Application Programming Interface to support ontology-based reasoning. We have developed an efficient ontology management module that automatically updates the ontology mappings each time a new version of the Epilepsy and Seizure Ontology is released. The Insight platform features a Role-based Access Control module to authenticate and effectively manage user access to different research studies. User access to Insight is managed by the Managing Epilepsy Well Network database steering committee consisting of representatives of all current collaborating centers of the Managing Epilepsy Well Network. New research studies are being continuously added to the Insight database and the size as well as the unique coverage of the dataset allows investigators to conduct

  14. The structural neuroanatomy of metacognitive insight in schizophrenia and its psychopathological and neuropsychological correlates.

    Science.gov (United States)

    Spalletta, Gianfranco; Piras, Fabrizio; Piras, Federica; Caltagirone, Carlo; Orfei, Maria Donata

    2014-09-01

    Lack of insight into illness is a multidimensional phenomenon that has relevant implications on clinical course and therapy compliance. Here, we focused on metacognitive insight in schizophrenia, that is, the ability to monitor one's changes in state of mind and sensations, with the aim of investigating its neuroanatomical, psychopathological, and neuropsychological correlates. Fifty-seven consecutive patients with Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition, Text Revision) diagnosis of schizophrenia were administered the Insight Scale, and comprehensive psychopathological and neuropsychological batteries. They underwent a high-resolution T1-weighted magnetic resonance imaging investigation. Gray matter (GM) and white matter (WM) volumes were analyzed on a voxel-by-voxel basis using Statistical Parametric Mapping 8. Reduced metacognitive insight was related to reduced GM volumes in the left ventrolateral prefrontal cortex, right dorsolateral prefrontal cortex and insula, and bilateral premotor area and putamen. Further, it was related to reduced WM volumes of the right superior longitudinal fasciculum, left corona radiata, left forceps minor, and bilateral cingulum. Increased metacognitive insight was related to increased depression severity and attentional control impairment, while the latter was related to increased GM volumes in brain areas linked to metacognitive insight. Results of this study suggest that prefrontal GM and WM bundles, all implied in cognitive control and self-reflection, may be the neuroanatomical correlates of metacognitive insight in schizophrenia. Further, higher metacognitive insight is hypothesized to be a risk factor for depression which may subsequently impair attention. This line of research may provide the basis for the development of cognitive interventions aimed at improving self-monitoring and compliance to treatment. PMID:24700789

  15. Systems mapping of HIV-1 infection

    Directory of Open Access Journals (Sweden)

    Hou Wei

    2012-10-01

    Full Text Available Abstract Mathematical models of viral dynamics in vivo provide incredible insights into the mechanisms for the nonlinear interaction between virus and host cell populations, the dynamics of viral drug resistance, and the way to eliminate virus infection from individual patients by drug treatment. The integration of these mathematical models with high-throughput genetic and genomic data within a statistical framework will raise a hope for effective treatment of infections with HIV virus through developing potent antiviral drugs based on individual patients’ genetic makeup. In this opinion article, we will show a conceptual model for mapping and dictating a comprehensive picture of genetic control mechanisms for viral dynamics through incorporating a group of differential equations that quantify the emergent properties of a system.

  16. Schizophrenia - Insight, Depression: A Correlation Study

    Directory of Open Access Journals (Sweden)

    Prasanth Ampalam

    2012-01-01

    Full Text Available Background: Schizophrenia is one of the severe forms of mental illness which demands enormous personal and economical costs. Recent years have attracted considerable interest in the dual problem of depression in schizophrenia and its relation to insight. Most clinicians believe that poor insight in patients with schizophrenia, though problematic for treatment adherence, may be protective with respect to suicide. The assumption is that patients who do not believe that they are ill are less likely to be suicidal. Alternatively, those patients with schizophrenia who recognize and acknowledge the illness will be more of a suicidal nature. Aim of the Study: The aim of the study is to find out the correlation between insight and depression in schizophrenic population. Materials and Methods: This study is a cross-sectional, single-centred, correlation study done in a total of 60 subjects. Inclusion Criteria - Subjects between 20-60 years, who were diagnosed to have schizophrenia as per International clasification of diseases-10 and who have given written consent to participate in the study. Exclusion Criteria - Subjects who have other diagnosis such as mood disorder, schizoaffective disorder, mental retardation, epilepsy or detectable organic disease and co morbid substance abuse are excluded from the study. Schizophrenics who have acute exacerbation are also excluded. Instruments - For insight assessment, schedule for assessment of insight, a three item rating scale, is used. For depressive symptoms assessment a nine item rating scale, Calgary depression rating scale, is administrated. Results: Insight and depression are strongly correlated in schizophrenic population with a Pearson correlation coefficient of 0.758. The correlation between insight and depression is high in subjects with less duration of illness. Conclusion: Better insight was significantly correlated with lower mood. In addition, it suggests that poor insight may protect against

  17. More 'mapping' in brain mapping: statistical comparison of effects

    DEFF Research Database (Denmark)

    Jernigan, Terry Lynne; Gamst, Anthony C.; Fennema-Notestine, Christine;

    2003-01-01

    The term 'mapping' in the context of brain imaging conveys to most the concept of localization; that is, a brain map is meant to reveal a relationship between some condition or parameter and specific sites within the brain. However, in reality, conventional voxel-based maps of brain function, or ...

  18. Mapping or Tracing? Rethinking Curriculum Mapping in Higher Education

    Science.gov (United States)

    Wang, Chia-Ling

    2015-01-01

    Curriculum mapping has been emphasized in recent curriculum innovations in higher education in the drive for global competitiveness. This paper begins by providing an outline of current discourses of curriculum mapping in higher education. Curriculum mapping is frequently associated with outcome-based learning and work readiness, and guiding the…

  19. Big Data Offers Novel Insights for Oncolytic Virus Immunotherapy

    Science.gov (United States)

    Swift, Stephanie L.; Stojdl, David F.

    2016-01-01

    Large-scale assays, such as microarrays, next-generation sequencing and various “omics” technologies, have explored multiple aspects of the immune response following virus infection, often from a public health perspective. Yet a lack of similar data exists for monitoring immune engagement during oncolytic virus immunotherapy (OVIT) in the cancer setting. Tracking immune signatures at the tumour site can create a snapshot or longitudinally analyse immune cell activation, infiltration and functionality within global populations or individual cells. Mapping immune changes over the course of oncolytic biotherapy—from initial infection to tumour stabilisation/regression through to long-term cure or escape/relapse—has the potential to generate important therapeutic insights around virus-host interactions. Further, correlating such immune signatures with specific tumour outcomes has significant value for guiding the development of novel oncolytic virus immunotherapy strategies. Here, we provide insights for OVIT from large-scale analyses of immune populations in the infection, vaccination and immunotherapy setting. We analyse several approaches to manipulating immune engagement during OVIT. We further explore immunocentric changes in the tumour tissue following immunotherapy, and compile several immune signatures of therapeutic success. Ultimately, we highlight clinically relevant large-scale approaches with the potential to strengthen future oncolytic strategies to optimally engage the immune system. PMID:26861383

  20. NEPR Geographic Zone Map 2015

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This geographic zone map was created by interpreting satellite and aerial imagery, seafloor topography (bathymetry model), and the new NEPR Benthic Habitat Map...

  1. NEPR Benthic Habitat Map 2015

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This benthic habitat map was created from a semi-automated habitat mapping process, using a combination of bathymetry, satellite imagery, aerial imagery and...

  2. Knowledge Map of Facilities Management

    DEFF Research Database (Denmark)

    Nenonen, Suvi; Jensen, Per Anker; Lindahl, Göran

    2014-01-01

    Purpose This paper aims to draft a knowledge map of the fragmented and multidisciplinary research of and relevant to FM. Facilities management knowledge map is a tool for presenting what relevant data and knowledge, a.k.a. knowledge, resides in different disciplines. Knowledge mapping is a step...... in creating an inventory of knowledge (i.e. the knowledge base) and developing/improving the processes of knowledge sharing in research, education and practice. Theory Knowledge mapping is discussed in terms of knowledge management. The research is connected to knowledge mapping in the facilities management...... profession, research and education. The knowledge map aims to contrast perspectives on how to map interdisciplinary research. Design/methodology/approach The Knowledge map is based on classification of 83 articles, including volume 2013 of Facilities (40 articles) and of Journal of Facilities Management (21...

  3. Map projections cartographic information systems

    CERN Document Server

    Grafarend, Erik W

    2006-01-01

    Offers a review of map projections (sphere, ellipsoidal, rotational surfaces) and of the geodetic datum transformations, in the context of Geographical Information Systems (GIS). This book also includes the reviews of computer vision and remote sensing space projective mappings.

  4. North America Synoptic Weather Maps

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Series of Synoptic Weather Maps. Maps contains a surface analysis comprised of plotted weather station observations, isobars indicating low and high-pressure...

  5. Newer insights in teledermatology practice

    Directory of Open Access Journals (Sweden)

    Garehatty Rudrappa Kanthraj

    2011-01-01

    Full Text Available The study and practice of dermatology care using interactive audio, visual, and data communications from a distance is called teledermatology. A teledermatology practice (TP provides teleconsultation as well tele-education. Initially, dermatologists used videoconference. Convenience, cost-effectiveness and easy application of the practice made "store and forward" to emerge as a basic teledermatology tool. The advent of newer technologies like third generation (3G and fourth generation (4G mobile teledermatology (MT and dermatologists′ interest to adopt tertiary TP to pool expert (second opinion to address difficult-to-manage cases (DMCs has resulted in a rapid change in TP. Online discussion groups (ODGs, author-based second opinion teledermatology (AST, or a combination of both are the types of tertiary TP. This article analyzes the feasibility studies and provides latest insight into TP with a revised classification to plan and allocate budget and apply appropriate technology. Using the acronym CAP-HAT, which represents five important factors like case, approach, purpose, health care professionals, and technology, one can frame a TP. Store-and-forward teledermatology (SAFT is used to address routine cases (spotters. Chronic cases need frequent follow-up care. Leg ulcer and localized vitiligo need MT while psoriasis and leprosy require SAFT. Pigmented skin lesions require MT for triage and combination of teledermoscopy, telepathology, and teledermatology for diagnosis. A self-practising dermatologist and national health care system dermatologist use SAFT for routine cases and a combination of ASTwith an ODG to address a DMC. A TP alone or in combination with face-to-face consultation delivers quality care.

  6. Mapping Deviant Democracy

    DEFF Research Database (Denmark)

    Seeberg, Michael

    2014-01-01

    A number of countries have emerged as stable (though minimalist) democracies despite low levels of modernization, lack of democratic neighbouring countries and other factors consistently related to democratic stability in the literature. The study of these deviant democracies is a promising new...... research field but it is afflicted by a notable problem, viz. the lack of a consensus as to which countries are actually instances of deviant democracy. The present article attempts to solve this problem by carrying out a comprehensive mapping of deviant democracies. First, I review the existing literature...... to provide an overview of the cases most often identified as deviant democracies. Second, I use a large-N analysis to systematically map deviant democracies. The analysis includes 159 countries covering the time period 1993–2008. The analysis points to 12 cases that merits further attention, viz...

  7. Graphene mobility mapping

    DEFF Research Database (Denmark)

    Buron, Jonas Christian Due; Pizzocchero, Filippo; Jepsen, Peter Uhd;

    2015-01-01

    Carrier mobility and chemical doping level are essential figures of merit for graphene, and large-scale characterization of these properties and their uniformity is a prerequisite for commercialization of graphene for electronics and electrodes. However, existing mapping techniques cannot directly...... assess these vital parameters in a non-destructive way. By deconvoluting carrier mobility and density from non-contact terahertz spectroscopic measurements of conductance in graphene samples with terahertz-transparent backgates, we are able to present maps of the spatial variation of both quantities over...... graphene indicates dominance by charged scatterers. Unexpectedly, significant variations in mobility rather than doping are the cause of large conductance inhomogeneities, highlighting the importance of statistical approaches when assessing large-area graphene transport properties....

  8. Diffusion Based Photon Mapping

    DEFF Research Database (Denmark)

    Schjøth, Lars; Sporring, Jon; Fogh Olsen, Ole

    2008-01-01

    . To address this problem, we introduce a photon mapping algorithm based on nonlinear anisotropic diffusion. Our algorithm adapts according to the structure of the photon map such that smoothing occurs along edges and structures and not across. In this way, we preserve important illumination features, while......Density estimation employed in multi-pass global illumination algorithms give cause to a trade-off problem between bias and noise. The problem is seen most evident as blurring of strong illumination features. In particular, this blurring erodes fine structures and sharp lines prominent in caustics...... eliminating noise. We demonstrate the applicability of our algorithm through a series of tests. In the tests, we evaluate the visual and computational performance of our algorithm comparing it to existing popular algorithms. Udgivelsesdato: December...

  9. MAPS Appraisal Report Form

    CERN Multimedia

    HR Department

    2005-01-01

    As announced in Weekly Bulletin 48/2004, from now onwards, the paper MAPS appraisal report form has been replaced by an electronic form, which is available via EDH (on the EDH desktop under Other Tasks / HR & Training) No changes have been made to the contents of the form. Practical information will be available on the web page http://cern.ch/ais/projs/forms/maps/info.htm, and information meetings will be held on the following dates: 18 January 2005: MAIN AUDITORIUM (500-1-001) from 14:00 to 15:30. 20 January 2005: AB AUDITORIUM II (864-1-D02) from14:00 to 15:30. 24 January 2005: AT AUDITORIUM (30-7-018) from 10:00 to 11:30. Human Resources Department Tel. 73566

  10. Conformal Complementarity Maps

    CERN Document Server

    Barbón, José L F

    2013-01-01

    We study quantum cosmological models for certain classes of bang/crunch singularities, using the duality between expanding bubbles in AdS with a FRW interior cosmology and perturbed CFTs on de Sitter space-time. It is pointed out that horizon complementarity in the AdS bulk geometries is realized as a conformal transformation in the dual deformed CFT. The quantum version of this map is described in full detail in a toy model involving conformal quantum mechanics. In this system the complementarity map acts as an exact duality between eternal and apocalyptic Hamiltonian evolutions. We calculate the commutation relation between the Hamiltonians corresponding to the different frames. It vanishes only on scale invariant states.

  11. Maps and statistics

    International Nuclear Information System (INIS)

    This document provides, supplying by more than 54 maps and tables, statistics on the petroleum industry and market. It covers the mine sites near Paris, in Aquitaine (France) and in north sea; the reserves; the petroleum and natural gas production in north sea; the refinery capacities; the petroleum production in CIS, North Africa, Egypt, Middle-East; the drilling activities; the turn over of petroleum, gas, para-petroleum, petrochemical industry and the industrialists; the refining in France; the chemical industry in France

  12. The grief map

    Science.gov (United States)

    Monteiro, L. H. A.

    2014-12-01

    Grieving is a natural human reaction to a significant loss. According to a psychiatric model, this process is characterized by a typical sequence of psychological changes. Here, I propose a discrete-time dynamical system, called the grief map, in order to represent the grieving process. The corresponding bifurcation diagram, which exhibits stationary, periodic, and chaotic behavior, is related to the stages of this sorrowful journey occurring during about 12 months post-loss.

  13. Mapping the cytoskeletal prestress

    OpenAIRE

    Park, Chan Young; Tambe, Dhananjay; Alencar, Adriano M.; Trepat, Xavier; Zhou, En Hua; Millet, Emil; Butler, James P.; Fredberg, Jeffrey J.

    2010-01-01

    Cell mechanical properties on a whole cell basis have been widely studied, whereas local intracellular variations have been less well characterized and are poorly understood. To fill this gap, here we provide detailed intracellular maps of regional cytoskeleton (CSK) stiffness, loss tangent, and rate of structural rearrangements, as well as their relationships to the underlying regional F-actin density and the local cytoskeletal prestress. In the human airway smooth muscle cell, we used micro...

  14. Intercreativity: Mapping Online Activism

    Science.gov (United States)

    Meikle, Graham

    How do activists use the Internet? This article maps a wide range of activist practice and research by applying and developing Tim Berners-Lee's concept of ‘intercreativity' (1999). It identifies four dimensions of Net activism: intercreative texts, tactics, strategies and networks. It develops these through examples of manifestations of Net activism around one cluster of issues: support campaigns for refugees and asylum seekers.

  15. Map of the Moon

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    China releases data about the Moon collected its first lunar probe China has finished the full map of the Moon based on data obtained by its lunar probe Chang ’e 1,said Ouyang Ziyuan,chief scientist of China’s lunar exploration program and an academician at the Chinese Academy of Sciences (CAS),at a press conference about the scientific achievements made by Chang’e 1 on July 16,2010.

  16. Mapping the Literature

    DEFF Research Database (Denmark)

    Boulus-Rødje, Nina

    2012-01-01

    As the utilization of various e-voting technologies has notably increased in the past few years, so has the amount of publications on experiences with these technologies. This article, will, therefore map the literature while highlighting some of the important topics discussed within the field of......-voting. Particular attention will be paid to non-technical dimensions, including socio-cultural, organizational and political dimensions of these implementations....

  17. MAP user's manual copyright

    International Nuclear Information System (INIS)

    The program MITMAP represents a set of general purpose, two- dimensional, finite element programs for the calculation of magnetic fields. It consists of the program MAP and MAP2DJ. The two programs are used to solve different electromagnetic problems, but they have a common set of subrountines for pre- and postprocessing. Originally separate programs, they have been combined to make modification easier. The manuals, however, will remain separate. The program MAP is described in this manual. MAP is applicable to the class of problems with two-dimensional-planar or axisymmetric - geometries, in which the current density and the magnetic vector potential have only a single nonvanishing component. The single component is associated with the direction that is perpendicular to the plane of the problem and is invariant with respect to that direction. Maxwell's equations can be reduced to a solver diffusion equation in terms of the single, nonvanishing component of the magnetic vector potential for planar problems and to a single component of a vector potential for planar problems and to a single component of a vector diffusion equation for axisymmetric problems. The magnetic permeability appears in the governing equation. The permeability may be a function of the magnetic flux density. In addition, any electrically conducting material present will have eddy currents induced by a time varying magnetic field. These eddy currents must be included in the solution process. This manual provides a description of the structure of the input data and output for the program. There are several example problems presented that illustrate the major program features. Appendices are included that contain a derivation of the governing equations and the application of the finite element method to the solution of the equations

  18. Skyrmions from Harmonic Maps

    OpenAIRE

    Zakrzewski, Wojtek

    2000-01-01

    We describe some relations between solitonic solutions of various models in different dimensions. We present some examples and then concentrate on some of our recent work (performed in collaboration with Ioannidou and Piette) \\cite{IPZ} \\cite{us2} which shows how some harmonic maps from S2 to CPN-1 can be used to find nontrivial spherically symmetric static solutions of the SU(N) Skyrme model in 3 dimensions and to generate some of its low energy field configurations.

  19. Teaching and assessing mind maps

    OpenAIRE

    Jennifer Wright

    2011-01-01

    The purpose of literacy interventions in higher education is to develop students’ competencies so they could cope with the literacy demands of their academic studies. One such competency is mind mapping. The literature provides strong arguments that mind mapping provides students with valuable organisational and heuristic tools and offers guidelines on how to draw mind maps. The issue of assessing mind maps is, however, generally absent. This paper explores the characteristics of effective mi...

  20. Knowledge Map of Facilities Management

    OpenAIRE

    Nenonen, Suvi; Jensen, Per Anker; Lindahl, Göran

    2014-01-01

    Purpose This paper aims to draft a knowledge map of the fragmented and multidisciplinary research of and relevant to FM. Facilities management knowledge map is a tool for presenting what relevant data and knowledge, a.k.a. knowledge, resides in different disciplines. Knowledge mapping is a step in creating an inventory of knowledge (i.e. the knowledge base) and developing/improving the processes of knowledge sharing in research, education and practice. Theory Knowledge mapping is discussed in...

  1. System of automated map design

    International Nuclear Information System (INIS)

    Preprint 'System of automated map design' contains information about the program shell for construction of territory map, performing level line drawing of arbitrary two-dimension field (in particular, the radionuclide concentration field). The work schedule and data structures are supplied, as well as data on system performance. The preprint can become useful for experts in radioecology and for all persons involved in territory pollution mapping or multi-purpose geochemical mapping. (author)

  2. Mapping Israel/Palestine

    Directory of Open Access Journals (Sweden)

    Christine Leuenberger

    2012-01-01

    studies and the sociology of knowledge in order to analyze the social context of map-making and the content and structure of maps. The focus is on how and why British, American, and Arab online news outlets depict the contested territories of Israel and the Palestinian Territories in often varied and inconsistent ways. Certain online news sources have been accused of political biases concerning the Israeli-Palestinian conflict, which arguably translates into particular maps and map layers being included in news stories. Rather than they are being a direct and pre-determined link between map-choice and politics, however, I argue that map-making can be understood as a form of ‘situated’ practice. In other words, the newsroom brings together various actors, materials, technologies and resources that enable and constrain certain activities. It is therefore local cultures, social and interactional contingencies, and institutional and political circumstances that impact map-making and explain how and why maps may converge with or diverge from politics at any given time and place. At the same time, the choice of certain maps and map layers in terms of their focus, content, design, and detail is inevitably selective and can hereby become politically meaningful. It is thus the various textual and visual signifiers and the contextual information included in a map that can become politics by other means. Moreover, the types and sources of news stories and their maps are also co-determined by power politics, the structural inequities between the state of Israel and a Palestinian state-in-the-making, and their respective ease of access to public relations infrastructures that can reach the public at large.

  3. The MAP Propulsion Subsystem

    Science.gov (United States)

    Davis, Gary T.; Bauer, Frank H. (Technical Monitor)

    2002-01-01

    This paper describes the requirements, design, integration, test, performance, and lessons learned of NASA's Microwave Anisotropy Probe (MAP) propulsion subsystem. MAP was launched on a Delta-II launch vehicle from NASA's Kennedy Space Center on June 30, 2001. Due to instrument thermal stability requirements, the Earth-Sun L2 Lagrange point was selected for the mission orbit. The L2 trajectory incorporated phasing loops and a lunar gravity assist. The propulsion subsystem's requirements are to manage momentum, perform maneuvers during the phasing loops to set up the lunar swingby, and perform stationkeeping at L2 for 2 years. MAP's propulsion subsystem uses 8 thrusters which are located and oriented to provide attitude control and momentum management about all axes, and delta-V in any direction without exposing the instrument to the sun. The propellant tank holds 72 kg of hydrazine, which is expelled by unregulated blowdown pressurization. Thermal management is complex because no heater cycling is allowed at L2. Several technical challenges presented themselves during I and T, such as in-situ weld repairs and in-situ bending of thruster tubes to accommodate late changes in the observatory CG. On-orbit performance has been nominal, and all phasing loop, mid-course correction, and stationkeeping maneuvers have been successfully performed to date.

  4. Making maps a visual guide to map design for GIS

    CERN Document Server

    Krygier, John

    2011-01-01

    Acclaimed for its innovative use of visual material, this book is engaging, clear, and compelling-exactly how an effective map should be. Nearly every page is organized around maps and other figures (many in full color) that illustrate all aspects of map making, including instructive examples of both good and poor design choices. The book covers everything from locating and processing data to making decisions about layout, symbols, color, and type. Readers are invited to think critically about both the technical features and social significance of maps as they learn to create better maps of t

  5. A quantitative transcriptome reference map of the normal human hippocampus.

    Science.gov (United States)

    Caracausi, Maria; Rigon, Vania; Piovesan, Allison; Strippoli, Pierluigi; Vitale, Lorenza; Pelleri, Maria Chiara

    2016-01-01

    We performed an innovative systematic meta-analysis of 41 gene expression profiles of normal human hippocampus to provide a quantitative transcriptome reference map of it, i.e. a reference typical value of expression for each of the 30,739 known mapped and the 16,258 uncharacterized (unmapped) transcripts. For this aim, we used the software called TRAM (Transcriptome Mapper), which is able to generate transcriptome maps based on gene expression data from multiple sources. We also analyzed differential expression by comparing the hippocampus with the whole brain transcriptome map to identify a typical expression pattern of this subregion compared with the whole organ. Finally, due to the fact that the hippocampus is one of the main brain region to be severely affected in trisomy 21 (the best known genetic cause of intellectual disability), a particular attention was paid to the expression of chromosome 21 (chr21) genes. Data were downloaded from microarray databases, processed, and analyzed using TRAM software. Among the main findings, the most over-expressed loci in the hippocampus are the expressed sequence tag cluster Hs.732685 and the member of the calmodulin gene family CALM2. The tubulin folding cofactor B (TBCB) gene is the best gene at behaving like a housekeeping gene. The hippocampus vs. the whole brain differential transcriptome map shows the over-expression of LINC00114, a long non-coding RNA mapped on chr21. The hippocampus transcriptome map was validated in vitro by assaying gene expression through several magnitude orders by "Real-Time" reverse transcription polymerase chain reaction (RT-PCR). The highly significant agreement between in silico and experimental data suggested that our transcriptome map may be a useful quantitative reference benchmark for gene expression studies related to human hippocampus. Furthermore, our analysis yielded biological insights about those genes that have an intrinsic over-/under-expression in the hippocampus. PMID

  6. The Global Trachoma Mapping Project

    OpenAIRE

    Anthony W. Solomon; Elizabeth Kurylo

    2014-01-01

    In the largest disease-mapping project ever conducted, health workers trained by the Global Trachoma Mapping Project have already examined the eyelids of more than 1 million people in nearly 1,000 districts since December 2012. The data collected are being used to create the first truly complete global map of trachoma and trichiasis, due in March 2015.

  7. Using Playground Maps for Movement

    Science.gov (United States)

    Colvin, A. Vonnie

    2016-01-01

    Many schools now decorate their outside hard surface areas with maps. These maps provide color and excitement to a playground and are a terrific teaching tool for geography. But these maps can easily be integrated into physical education as well to promote both physical activity as well as knowledge of geography. The purpose of this article is to…

  8. Genetic algorithms for map labeling

    NARCIS (Netherlands)

    Dijk, Steven Ferdinand van

    2002-01-01

    Map labeling is the cartographic problem of placing the names of features (for example cities or rivers) on the map. A good labeling has no intersections between labels. Even basic versions of the problem are NP-hard. In addition, realistic map-labeling problems deal with many cartographic constr

  9. The Map to LOINC Project

    OpenAIRE

    Khan, Agha N.; Russell, Dorothy; Moore, Catherine; Rosario, Arnulfo C.; Griffith, Stanley P.; Bertolli, Jeanne

    2003-01-01

    We describe a pilot project to standardize local laboratory test names to Logical Observation Identifier Names and Codes (LOINC) at five Indian Health Service (IHS) medical facilities. An automated mapping tool was developed to assign LOINC codes. The laboratory test names not mapped to LOINC by the mapping tool were assigned LOINC codes manually. The results achieved matched current benchmarks.

  10. Developmentally Appropriate Map Skills Instruction.

    Science.gov (United States)

    Maxim, George W.

    1997-01-01

    Describes a kindergarten/first-grade and a second-grade program for teaching map reading skills. Suggests that map- reading instruction is required to improve children's geography knowledge. Provides ideas on how to observe the environment, use photos, encourage block play, use books, share maps, construct a model of the classroom, read cardinal…

  11. The Global Trachoma Mapping Project

    Directory of Open Access Journals (Sweden)

    Anthony W Solomon

    2014-04-01

    Full Text Available In the largest disease-mapping project ever conducted, health workers trained by the Global Trachoma Mapping Project have already examined the eyelids of more than 1 million people in nearly 1,000 districts since December 2012. The data collected are being used to create the first truly complete global map of trachoma and trichiasis, due in March 2015.

  12. Geologic map of Io

    Science.gov (United States)

    Williams, David A.; Keszthelyi, Laszlo P.; Crown, David A.; Yff, Jessica A.; Jaeger, Windy L.; Schenk, Paul M.; Geissler, Paul E.; Becker, Tammy L.

    2011-01-01

    Io, discovered by Galileo Galilei on January 7–13, 1610, is the innermost of the four Galilean satellites of the planet Jupiter (Galilei, 1610). It is the most volcanically active object in the Solar System, as recognized by observations from six National Aeronautics and Space Administration (NASA) spacecraft: Voyager 1 (March 1979), Voyager 2 (July 1979), Hubble Space Telescope (1990–present), Galileo (1996–2001), Cassini (December 2000), and New Horizons (February 2007). The lack of impact craters on Io in any spacecraft images at any resolution attests to the high resurfacing rate (1 cm/yr) and the dominant role of active volcanism in shaping its surface. High-temperature hot spots detected by the Galileo Solid-State Imager (SSI), Near-Infrared Mapping Spectrometer (NIMS), and Photopolarimeter-Radiometer (PPR) usually correlate with darkest materials on the surface, suggesting active volcanism. The Voyager flybys obtained complete coverage of Io's subjovian hemisphere at 500 m/pixel to 2 km/pixel, and most of the rest of the satellite at 5–20 km/pixel. Repeated Galileo flybys obtained complementary coverage of Io's antijovian hemisphere at 5 m/pixel to 1.4 km/pixel. Thus, the Voyager and Galileo data sets were merged to enable the characterization of the whole surface of the satellite at a consistent resolution. The United States Geological Survey (USGS) produced a set of four global mosaics of Io in visible wavelengths at a spatial resolution of 1 km/pixel, released in February 2006, which we have used as base maps for this new global geologic map. Much has been learned about Io's volcanism, tectonics, degradation, and interior since the Voyager flybys, primarily during and following the Galileo Mission at Jupiter (December 1995–September 2003), and the results have been summarized in books published after the end of the Galileo Mission. Our mapping incorporates this new understanding to assist in map unit definition and to provide a global synthesis

  13. RgoogleMaps and loa: Unleashing R Graphics Power on Map Tiles

    Directory of Open Access Journals (Sweden)

    Markus Loecher

    2015-02-01

    In addition to solving the generic task of plotting on a map background in R, we introduce several specific algorithms to detect and visualize spatio-temporal clusters. This task can often be reduced to detecting over-densities in space relative to a background density. The relative density estimation is framed as a binary classification problem. An integrated hotspot visualizer is presented which allows the efficient identification and visualization of clusters in one environment. Competing clustering methods such as the scan statistic and the density scan offer higher detection power at a much larger computational cost. Such clustering methods can then be extended using the lattice trellis framework to provide further insight into the relationship between clusters and potentially influential parameters. While there are other options for such map mashups we believe that the integration of RgoogleMaps and lattice using loa can in certain circumstances be advantageous, e.g., by providing a highly intuitive working environment for multivariate analysis and flexible testbed for the rapid development of novel data visualizations.

  14. Blindness and Insight in King Lear

    Institute of Scientific and Technical Information of China (English)

    岳元玉

    2008-01-01

    This paper intends to explore how William Shakespeare illustrates the theme of blindness and insight in his great tragedy "King Lear".Four characters’ deeds and their fate are used as a case study to examine what blindness is,what insight is,and the relationship between the two.The writer finds that by depicting the characters’ deeds and their fate in a double plot,Shakespeare renders the folly of blindness,the transition from blindness to insight,and the use of reason and thought to understand the truth.

  15. Concept mapping: A supervision strategy for introducing case conceptualization skills to novice therapists.

    Science.gov (United States)

    Liese, Bruce S; Esterline, Kate M

    2015-06-01

    Case conceptualization, a term synonymous with case formulation, is an essential psychotherapy skill. Novice therapists enter into the practice of psychotherapy with limited case conceptualization skills. Hence, an important goal when supervising novice therapists is to effectively teach these skills. Concept mapping facilitates case conceptualization skills through the process of methodically creating graphic representations of clients' problems and dynamic relationships between these problems. This article introduces a highly structured and practical 4-stage approach to supervision that effectively introduces case formulation skills to novice therapists using concept mapping. It is assumed that concept maps, when shared with clients, function as an intervention to facilitate insight and change.

  16. Appropriate care for shelter-based abused women: concept mapping with Dutch clients and professionals

    NARCIS (Netherlands)

    Jonker, I.E.; Jansen, C.C.M.; Christians, M.G.M.; Wolf, J.R.L.M.

    2014-01-01

    We conducted a concept mapping exercise to gain insight into the perspectives held by abused women and professionals with regard to appropriate care in Dutch women's shelters. Three brainstorming sessions generated 92 statements that were then rated by 56 clients and 51 professionals. A total of 11

  17. A guide of patent map

    International Nuclear Information System (INIS)

    This book introduces application and characteristic of patent information, types of patent information data and research of patent information, arrangement of patent information and patent map, analysis of patent information, necessity, writing period arrangement way of patent map, cases of patent map on selection of task of research and development, system of research and development and application, examples of PM such as MAP by year, application, technique, Inventor, and claim point map and computerization like data arrangement of PM patent, collection of analysis range and item analysis of patent, cases and written reports on patent analysis.

  18. Mapping the human protein interactome

    Institute of Scientific and Technical Information of China (English)

    Daniel Figeys

    2008-01-01

    Interactions are the essence of all biomolecules because they cannot fulfill their roles without interacting with other molecules. Hence, mapping the interactions of biomolecules can be useful for understanding their roles and functions. Furthermore, the development of molecular based systems biology requires an understanding of the biomolecular interactions. In recent years, the mapping of protein-protein interactions in different species has been reported, but few reports have focused on the large-scale mapping of protein-protein interactions in human. Here, we review the developments in protein interaction mapping and we discuss issues and strategies for the mapping of the human protein interactome.

  19. Looking for an old map

    Science.gov (United States)

    ,

    1996-01-01

    Many people want maps that show an area of the United States as it existed many years ago. These are called historical maps, and there are two types. The most common type consists of special maps prepared by commercial firms to show such historical features as battle-fields, military routes, or the paths taken by famous travelers. Typically, these maps are for sale to tourists at the sites of historical events. The other type is the truly old map--one compiled by a surveyor or cartographer many years ago. Lewis and Clark, for example, made maps of their journeys into the Northwest Territories in 1803-6, and originals of some of these maps still exist.

  20. Radon mapping strategies in Austria.

    Science.gov (United States)

    Gruber, V; Ringer, W; Wurm, G; Friedmann, H

    2015-11-01

    According to current European and international recommendations (e.g. by IAEA, WHO and European Union), countries shall identify high radon areas. In Austria, this task was initiated already in the early 1990s, which yielded the first Austrian Radon Potential Map. This map is still in use, updated with recent indoor radon data in 2012. The map is based on radon gas measurements in randomly selected dwellings, normalised to a standard situation. To meet the current (legal) requirements, uncertainties in the existing Austrian radon map should be reduced. A new indoor radon survey with a different sampling strategy was started, and possible mapping methods are studied and tested. In this paper, the methodology for the existing map as well as the planned strategies to improve this map is discussed.