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Sample records for caudwell xtreme everest

  1. Closed and open breathing circuit function in healthy volunteers during exercise at Mount Everest base camp (5300 m).

    LENUS (Irish Health Repository)

    McMorrow, R C N

    2012-08-01

    We present a randomised, controlled, crossover trial of the Caudwell Xtreme Everest (CXE) closed circuit breathing system vs an open circuit and ambient air control in six healthy, hypoxic volunteers at rest and exercise at Everest Base Camp, at 5300 m. Compared with control, arterial oxygen saturations were improved at rest with both circuits. There was no difference in the magnitude of this improvement as both circuits restored median (IQR [range]) saturation from 75%, (69.5-78.9 [68-80]%) to > 99.8% (p = 0.028). During exercise, the CXE closed circuit improved median (IQR [range]) saturation from a baseline of 70.8% (63.8-74.5 [57-76]%) to 98.8% (96.5-100 [95-100]%) vs the open circuit improvement to 87.5%, (84.1-88.6 [82-89]%; p = 0.028). These data demonstrate the inverse relationship between supply and demand with open circuits and suggest that ambulatory closed circuits may offer twin advantages of supplying higher inspired oxygen concentrations and\\/or economy of gas use for exercising hypoxic adults.

  2. Onboard Photo of Mt. Everest

    Science.gov (United States)

    2002-01-01

    Astronaut Daniel W. Bursch, Expedition Four flight engineer, was delighted in capturing this image of Mt. Everest in the Himalayan Range from aboard the International Space Station (ISS). The mountain is near frame center. Because the photo was taken close to orbital sunrise, the low sun angle gave tremendous relief to the mountains. Named for Sir George Everest, the British surveyor-general of India, Mount Everest is the tallest point on earth. Standing 29,028 feet tall, it is 5 1/2 miles above sea level. Mount Everest is located half in Nepal and half in Tibet.

  3. Griffith Pugh, pioneer Everest physiologist.

    Science.gov (United States)

    Ward, Michael P; Milledge, James S

    2002-01-01

    Lewis Griffith Cresswell Evans Pugh (1909-1994), best known as the physiologist on the successful 1953 British Everest Expedition, inspired a generation of scientists in the field of altitude medicine and physiology in the decades after World War II. This paper details his early life, his introduction to exercise physiology during the war, and his crucially important work in preparation for the Everest expedition on Cho Oyu in 1952. Pugh's other great contribution to altitude physiology was as scientific leader of the 1960-1961 Himalayan Scientific and Mountaineering Expedition (the Silver Hut), and the origins and results of this important expedition are discussed. He had a major and continuing interest in the physiology of cold, especially in real-life situations in Antarctica, exposure to cold wet conditions on hills in Britain, and in long distance swimming. He also extended his interest to Olympic athletes at moderate altitude (Mexico City) and to heat stress in athletes. Pugh's strength as a physiologist was his readiness to move from laboratory to fieldwork with ease and his rigor in applying the highest standards in both situations. He led by example in both his willingness to act as a subject for experiments and in his attention to detail. He was not an establishment figure; he was critical of authority and well known for his eccentricity, but he inspired great loyalty in those who worked with him.

  4. Performance and sex differences in 'Isklar Norseman Xtreme Triathlon'.

    Science.gov (United States)

    Knechtle, Beat; Nikolaidis, Pantelis Theodoros; Stiefel, Michael; Rosemann, Thomas; Rüst, Christoph Alexander

    2016-10-31

    The performance and sex differences of long-distance triathletes competing in 'Ironman Hawaii' are well investigated. However, less information is available with regards to triathlon races of the Ironman distance held under extreme environmental conditions (e.g. extreme cold) such as the 'Isklar Norseman Xtreme Triathlon' which started in 2003. In 'Isklar Norseman Xtreme Triathlon', athletes swim at a water temperature of ~13-15°C, cycle at temperatures of ~5-20°C and run at temperatures of ~12-28°C in the valley and of ~2-12°C at Mt. Gaustatoppen. This study analysed the performance trends and sex differences in 'Isklar Norseman Xtreme Triathlon' held from 2003 to 2015 using mixed-effects regression analyses. During this period, a total of 175 women (10.6%) and 1,852 men (89.4%) successfully finished the race. The number of female (r² = 0.53, P = 0.0049) and male (r² = 0.37, P = 0.0271) finishers increased and the men-to-women ratio decreased (r² = 0.86, P Men were faster than women in cycling (25.41 ± 2.84 km/h versus 24.25 ± 2.17 km/h) (P running (7.43 ± 1.13 km/h vs. 7.31 ± 0.93 km/h) and overall race time (874.57 ± 100.62 min vs. 899.95 ± 90.90 min) (P > 0.05). Across years, women improved in swimming and both women and men improved in cycling and in overall race time (P running, however, neither women nor men improved (P > 0.05). In summary, in 'Isklar Norseman Xtreme Triathlon' from 2003 to 2015, the number of successful women increased across years, women achieved a similar performance to men in swimming, cycling and overall race time, and women improved across, years in swimming, cycling and overall race time.

  5. Meteorological observations on Mount Everest in 2005

    Institute of Scientific and Technical Information of China (English)

    Xie Aihong; Qin Dahe; Ren Jiawen; Qin Xiang; Xiao Cunde; Hou Shugui; Kang Shichang; Yang Xingguo; Jiang Youyan

    2007-01-01

    Mount Everest, the highest point on the Earth is often referred to as the earth's third pole as such the place is relatively inaccessible and little is known about its meteorology. In April 2005, an automatic weather station was installed at the mountain's North Col (6523 ma. S. L. ). According to the observational 10-minute mean and daily records, the meteorological characteristics were analyzed.All the meteorological elements displayed obvious diurnal variations during May 1 to July 22, 2005. The monthly variation of daily meteorological elements on Mount Everest coincided with that on Dingri, the closest routine meteorological station, with the high correlation coefficients of 0. 928, 0. 877, 0. 682, 0. 755, 0. 826 and 0. 676 ( n = 83, p < 0. 001) for mean temperature, minimum temperature, maximum temperature, relative humidity, pressure and wind speed, respectively. Furthermore, the vertical mean gradient of temperature was above 0.6℃/100 m, especially for the daily maximum temperature. Most weather events on Mount Everest prominently appeared on the same day as those on Dingri, especially those from daily mean pressure, temperature and relative humidity with the cross-correlation coefficients of 0. 673, 0. 485 and 0. 487 ( n = 83, p < 0. 001 ), respectively. Some other weather events on Mount Everest lagged one-day behind those on Dingri. Furthermore, forecasting of the weather events on Mount Everest from pressure on Dingri was more reliable than those from the other meteorological elements. The conclusions are much important for research on meteorology and climate changes in the region.

  6. Using the Everest Team Simulation to Teach Threshold Concepts

    Science.gov (United States)

    Nichols, Elizabeth; Wright, April L.

    2015-01-01

    This resource review focuses on "Leadership and Team Simulation: Everest V2" released by Harvard Business Publishing. The review describes the simulation's story line of a commercial team expedition climbing to the summit of Mount Everest along with the simulation's architecture and key features. Building on Wright and Gilmore's (2012)…

  7. The CDF II eXtremely Fast Tracker Upgrade

    CERN Document Server

    Fedorko, I; Errede, D; Gerberich, H; Junk, T; Kasten, M; Levine, S; Mokos, R; Pitts, K; Rogers, E; Veramendi, G; Azzurri, P; Donati, S; Staveris-Polykalas, A; Cochran, E; Efron, J; Gartner, J; Hughes, R; Johnson, M; Kilminster, B; Lannon, K; McKim, J; Olivito, D; Parks, B; Slaunwhite, J; Winer, B; Dittmann, J; Hewamanage, S; Krumnack, N; Wilson, J S; Erbacher, R; Forrest, R; Ivanov, A; Soha, A; Flanagan, G; Jones, T; Holm, S; Klein, R; Schmidt, E E; Scott, L; Shaw, T; Wilson, P J

    2008-01-01

    The CDF II eXtremely Fast Tracker (XFT) is the trigger processor which reconstructs charged particle tracks in the transverse plane of the central tracking chamber. The XFT tracks are also extrapolated to the electromagnetic calorimeter and muon chambers to generate trigger electron and muon candidates. The XFT is crucial for the entire CDF II physics program: it detects high pT leptons from W/Z and heavy flavor decays and, in conjunction with the Level 2 processors, it identifies secondary vertices from beauty decays. The XFT has thus been crucial for the recent measurement of the oscilation and Σb discovery. The increase of the Tevatron instantaneous luminosity demanded an upgrade of the system to cope with the higher occupancy of the chamber. In the upgraded XFT, three dimensional tracking reduces the level of fake tracks and measures the longitudinal track parameters, which strongly reinforce the trigger selections. This allows to mantain the trigger perfectly efficient at the record luminosities 2–3·...

  8. Final report : Phase III targeted investigation, Everest, Kansas.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2006-01-31

    The Commodity Credit Corporation (CCC), an agency of the U.S. Department of Agriculture (USDA), formerly operated grain storage facilities at two different locations at Everest, Kansas (Figure 1.1). One facility (referred to in this report as the Everest facility) was at the western edge of the city. The second facility (referred to in this report as Everest East) was about 0.5 mi northeast of the town. The CCC/USDA operated these facilities from the early 1950s until the early 1970s, at a time when commercial fumigants containing carbon tetrachloride were in common use by the CCC/USDA and private industry for the preservation of grain in storage. In 1997 the Kansas Department of Health and Environment (KDHE) sampled several domestic drinking water and non-drinking water wells in the Everest area as part of the CCC/USDA Private Well Sampling Program. All of the sampled wells were outside the Everest city limits. Carbon tetrachloride contamination was identified at a single domestic drinking water well (the Nigh well, DW06; Figure 1.1) approximately 3/8 mi northwest of the former Everest CCC/USDA grain storage facility. Subsequent KDHE investigations suggested that the contamination in DW06 could be linked to the former use of grain fumigants at the CCC/USDA facility. For this reason, the CCC/USDA is conducting a phased environmental study to determine the source and extent of the carbon tetrachloride contamination at Everest and to identify potential remedial options. The studies are being performed by the Environmental Research Division of Argonne National Laboratory. Two phases of investigation were completed previously; this report presents the findings of the targeted Phase III investigation at Everest.

  9. EVEREST: Pixel Level Decorrelation of K2 Light Curves

    Science.gov (United States)

    Luger, Rodrigo; Agol, Eric; Kruse, Ethan; Barnes, Rory; Becker, Andrew; Foreman-Mackey, Daniel; Deming, Drake

    2016-10-01

    We present EPIC Variability Extraction and Removal for Exoplanet Science Targets (EVEREST), an open-source pipeline for removing instrumental noise from K2 light curves. EVEREST employs a variant of pixel level decorrelation to remove systematics introduced by the spacecraft’s pointing error and a Gaussian process to capture astrophysical variability. We apply EVEREST to all K2 targets in campaigns 0–7, yielding light curves with precision comparable to that of the original Kepler mission for stars brighter than {K}p≈ 13, and within a factor of two of the Kepler precision for fainter targets. We perform cross-validation and transit injection and recovery tests to validate the pipeline, and compare our light curves to the other de-trended light curves available for download at the MAST High Level Science Products archive. We find that EVEREST achieves the highest average precision of any of these pipelines for unsaturated K2 stars. The improved precision of these light curves will aid in exoplanet detection and characterization, investigations of stellar variability, asteroseismology, and other photometric studies. The EVEREST pipeline can also easily be applied to future surveys, such as the TESS mission, to correct for instrumental systematics and enable the detection of low signal-to-noise transiting exoplanets. The EVEREST light curves and the source code used to generate them are freely available online.

  10. Architecture and Design in eXtreme Programming; Introducing "Developer Stories"

    DEFF Research Database (Denmark)

    Jensen, Rolf Njor; Møller, Thomas; Sönder, Peter;

    2006-01-01

    This article introduces a new practice to eXtreme Programming (XP): Developer stories. The goal of these stories and their creation process is to incorporate architectural planning to XP thus ensuring a viable architecture. By conducting a small development project using XP, we find...

  11. Tracking Change in rapid and eXtreme Development: A Challenge to SCM-tools?

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak

    2001-01-01

    the tool does its job, change descriptions must be memorised until your next check-in, etc. This kind of overhead and disruption does not fit well with fast-paced development processes like rapid prototyping, explorative programming, and eXtreme Programming that favour creativity, speed, and communication...

  12. EVEREST: Pixel Level Decorrelation of K2 Light curves

    CERN Document Server

    Luger, Rodrigo; Kruse, Ethan; Barnes, Rory; Becker, Andrew; Foreman-Mackey, Daniel; Deming, Drake

    2016-01-01

    We present EVEREST, an open-source pipeline for removing instrumental noise from K2 light curves. EVEREST employs a variant of pixel level decorrelation (PLD) to remove systematics introduced by the spacecraft's pointing error and a Gaussian process (GP) to capture astrophysical variability. We apply EVEREST to all K2 targets in campaigns 0-7, yielding light curves with precision comparable to that of the original Kepler mission for stars brighter than $K_p \\approx 13$, and within a factor of two of the Kepler precision for fainter targets. We perform cross-validation and transit injection and recovery tests to validate the pipeline, and compare our light curves to the other de-trended light curves available for download at the MAST High Level Science Products archive. We find that EVEREST achieves the highest average precision of any of these pipelines for unsaturated K2 stars. The improved precision of these light curves will aid in exoplanet detection and characterization, investigations of stellar variabi...

  13. XP: eXtreme Programming, het softwareontwikkelproces XP in .Net-projecten

    OpenAIRE

    Boydens, Jeroen; van Dooren, Marko; Steegmans, Eric

    2005-01-01

    Dit artikel bevat een omschrijving van de essentiële onderdelen van het ontwikkelproces eXtreme Programming (XP). Eerst zetten we een aantal gebeurtenissen en gevolgen in het XP-proces op een rij, waarna we een SWOT-ana- lyse (sterkte, zwakte, mogelijkheden, bedreigingen) geven om de succesfactoren van het XP-proces te identificeren. We besluiten met een overzicht van de belangrijkste voordelen en aandachtspunten van het XP-proces.

  14. EVER-EST: a virtual research environment for Earth Sciences

    Science.gov (United States)

    Marelli, Fulvio; Albani, Mirko; Glaves, Helen

    2016-04-01

    There is an increasing requirement for researchers to work collaboratively using common resources whilst being geographically dispersed. By creating a virtual research environment (VRE) using a service oriented architecture (SOA) tailored to the needs of Earth Science (ES) communities, the EVEREST project will provide a range of both generic and domain specific data management services to support a dynamic approach to collaborative research. EVER-EST will provide the means to overcome existing barriers to sharing of Earth Science data and information allowing research teams to discover, access, share and process heterogeneous data, algorithms, results and experiences within and across their communities, including those domains beyond Earth Science. Researchers will be able to seamlessly manage both the data involved in their computationally intensive disciplines and the scientific methods applied in their observations and modelling, which lead to the specific results that need to be attributable, validated and shared both within the community and more widely e.g. in the form of scholarly communications. Central to the EVEREST approach is the concept of the Research Object (RO) , which provides a semantically rich mechanism to aggregate related resources about a scientific investigation so that they can be shared together using a single unique identifier. Although several e-laboratories are incorporating the research object concept in their infrastructure, the EVER-EST VRE will be the first infrastructure to leverage the concept of Research Objects and their application in observational rather than experimental disciplines. Development of the EVEREST VRE will leverage the results of several previous projects which have produced state-of-the-art technologies for scientific data management and curation as well those which have developed models, techniques and tools for the preservation of scientific methods and their implementation in computational forms such as

  15. EVEREST: a virtual research environment for the Earth Sciences

    Science.gov (United States)

    Glaves, H. M.; Marelli, F.; Albani, M.

    2015-12-01

    There is an increasing requirement for researchers to work collaboratively using common resources whilst being geographically dispersed. By creating a virtual research environment (VRE) using a service oriented architecture (SOA) tailored to the needs of Earth Science (ES) communities, the EVEREST project will provide a range of both generic and domain specific data management services to support a dynamic approach to collaborative research. EVER-EST will provide the means to overcome existing barriers to sharing of Earth Science data and information allowing research teams to discover, access, share and process heterogeneous data, algorithms, results and experiences within and across their communities, including those domains beyond Earth Science. Data providers will be also able to monitor user experiences and collect feedback through the VRE, improving their capacity to adapt to the changing requirements of their end-users. The EVER-EST e-infrastructure will be validated by four virtual research communities (VRC) covering different multidisciplinary ES domains: including ocean monitoring, selected natural hazards (flooding, ground instability and extreme weather events), land monitoring and risk management (volcanoes and seismicity). Each of the VRC represents a different collaborative use case for the VRE according to its own specific requirements for data, software, best practice and community engagement. The diverse use cases will demonstrate how the VRE can be used for a range of activities from straight forward data/software sharing to investigating ways to improve cooperative working. Development of the EVEREST VRE will leverage on the results of several previous projects which have produced state-of-the-art technologies for scientific data management and curation as well those initiatives which have developed models, techniques and tools for the preservation of scientific methods and their implementation in computational forms such as scientific workflows.

  16. Annual report of groundwater monitoring at Everest, Kansas in 2011.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M. (Environmental Science Division)

    2011-12-19

    Everest, Kansas, is a small rural community (population approximately 300) located in the southeast corner of Brown County, in the northeastern corner of Kansas. Carbon tetrachloride and chloroform contamination in groundwater at Everest was initially identified in 1997 as a result of testing performed under the Commodity Credit Corporation/U.S. Department of Agriculture (CCC/USDA) private well sampling program conducted by the Kansas Department of Health and Environment (KDHE). The KDHE collected samples from seven private wells in and near Everest. Carbon tetrachloride and chloroform were found in only one of the wells, the Donnie Nigh domestic well (owned at that time by Tim Gale), approximately 3/8 mi northwest of the former Everest CCC/USDA facility. Carbon tetrachloride and chloroform were detected at 121 {mu}g/L and 4 {mu}g/L, respectively. Nitrate was found at 12.62 mg/L. The USDA subsequently connected the Nigh residence to the Everest public water supply system. The findings of the 2011 monitoring at Everest support the following conclusions: (1) Measurements of groundwater levels obtained manually during annual monitoring in 2009-2011 (and through the use of automatic recorders in 2002-2010) have consistently indicated an initial direction of groundwater flow from the former CCC/USDA facility to the north-northwest and toward the Nigh property, then west-southwest from the Nigh property toward the intermittent creek that lies west of the former CCC/USDA facility and the Nigh property. (2) At most of the monitored locations, carbon tetrachloride concentrations decreased in April 2011 relative to 2010 results. Noteworthy decreases of > 50% occurred at locations MW4, MW60, and MW88, in the most concentrated part of the plume. (3) Comparison of accumulated data demonstrates that the area of the carbon tetrachloride plume with concentrations > 200 {mu}g/L has decreased markedly over time and suggests a generally decreasing trend in contaminant levels. (4) The

  17. Nation related participation and performance trends in 'Norseman Xtreme Triathlon' from 2006 to 2014.

    Science.gov (United States)

    Rüst, Christoph A; Bragazzi, Nicola Luigi; Signori, Alessio; Stiefel, Michael; Rosemann, Thomas; Knechtle, Beat

    2015-01-01

    We investigated the nation related participation and performance trends in triathletes competing in 'Norseman Xtreme Triathlon' between 2006 and 2014 using mixed models, one-way analysis of variance and multi-variate regression analyses. A total of 1594 athletes (139 women and 1455 men) originating from 34 different countries finished the race. Most of the athletes originated from Norway, Germany, Great Britain, Sweden, USA and France. In the mixed model analysis considering all finishers (n = 1594), with calendar year, sex and country as independent and overall race time as dependent variable, calendar year (p Women were slower than men, but women reduced this gender gap year after year and above all in the year 2007 (p = 0.001). Athletes from Norway and Germany were faster than those from Great Britain and other countries. Split times of the discipline decreased throughout the years. In particular, the discipline having more impact on overall race time was cycling. Most of the podiums were achieved by Norwegian women and men. For women, the fastest split and transition times were achieved by Norwegian women with exception of the run where German women were faster. Norwegian men were the fastest in split and transition times although French athletes were the fastest in swimming. Across years, the annual three fastest Norwegian women improved in cycling, running, overall race time and transition times but not Norwegian and German men. British men, however, improved running split times and transition times. To summarize, most of the finishers in 'Norseman Xtreme Triathlon' originated from Norway and the fastest race times were achieved by Norwegian women and men. Norwegian women improved race times across years but not Norwegian men.

  18. Airborne reconnaissance and Mount Everest: an historical perspective

    Science.gov (United States)

    Greer, Jerry D.

    1994-10-01

    In 1933, aerial cameras had been developed that worked essentially as they do today. Aerial surveys were made, stereo plotters produced maps, and the science of photogrammetry was advancing. However, aircraft development had a long way to go before the SR-71 came along. Over the years, the general complexity of taking photographs from above increased by orders of magnitude. A 1933 British flight in two bi-wing aircraft over Mount Everest on an aerial survey mission is compared to a 1984 Space Shuttle flight dedicated to aerial, or more accurately, space photography. The comparison leads to the conclusion that in exploration, it is important that people involved must be given latitude to exercise self-initiative if we are to be successful in the exploration of the solar system and galaxy.

  19. Annual report of groundwater monitoring at Everest, Kansas, in 2010.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M. (Environmental Science Division)

    2011-03-21

    The Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) began its environmental investigations at Everest, Kansas, in 2000. The work at Everest is implemented on behalf of the CCC/USDA by Argonne National Laboratory, under the oversight of the Kansas Department of Health and Environment (KDHE). The results of the environmental investigations have been reported in detail (Argonne 2001, 2003, 2006a,b). The lateral extent of the carbon tetrachloride in groundwater over the years of investigation has been interpreted as shown in Figure 1.1 (2001-2002 data), Figure 1.2 (2006 data), Figure 1.3 (2008 data), and Figure 1.4 (2009 data). The pattern of groundwater flow and inferred contaminant migration has consistently been to the north-northwest from the former CCC/USDA facility toward the Nigh property, and then west-southwest from the Nigh property (e.g., Figure 1.5 [2008 data] and Figure 1.6 [2009 data]). Both the monitoring data for carbon tetrachloride and the low groundwater flow rates estimated for the Everest aquifer unit (Argonne 2003, 2006a,b, 2008) indicate slow contaminant migration. On the basis of the accumulated findings, in March 2009 the CCC/USDA developed a plan for annual monitoring of the groundwater and surface water. This current monitoring plan (Appendix A in the report of monitoring in 2009 [Argonne 2010]) was approved by the KDHE (2009a). Under this plan, the monitoring wells are sampled by the low-flow procedure, and sample preservation, shipping, and analysis activities are consistent with previous work at Everest. The annual sampling will continue until identified conditions at the site indicate a technical justification for a change. The first annual sampling event under the new monitoring plan took place in April 2009. The results of analyses for volatile organic compounds (VOCs) and water level measurements were consistent with previous observations (Figures 1.1-1.4). No carbon tetrachloride was detected in surface

  20. Modelling glacier change in the Everest region, Nepal Himalaya

    Directory of Open Access Journals (Sweden)

    J. M. Shea

    2014-10-01

    Full Text Available In this study, we apply a glacier mass balance and ice redistribution model to simulate historical and future glacier change in the Everest region of Nepal. High-resolution temperature and precipitation fields derived from gridded APHRODITE data, and validated against independent station observations from the EVK2CNR network, are used to drive the historical model from 1961 to 2007. The model is calibrated against geodetically derived estimates of net glacier mass change from 1992 to 2008, termini position of four large glaciers at the end of the calibration period, average velocities observed on selected debris-covered glaciers, and total glacierized area. We integrate field-based observations of glacier mass balance and ice thickness with remotely-sensed observations of decadal glacier change to validate the model. Between 1961 and 2007, the mean modelled volume change over the Dudh Kosi basin is −6.4 ± 1.5 km3, a decrease of 15.6% from the original estimated ice volume in 1961. Modelled glacier area change between 1961 and 2007 is −101.0 ± 11.4 km2, a decrease of approximately 20% from the initial extent. Scenarios of future climate change, based on CMIP5 RCP4.5 and RCP8.5 end members, suggest that glaciers in the Everest region will continue to lose mass through the 21st century. Glaciers in the basin are concentrated between 5000 and 6000 m of elevation, and are thus expected to be sensitive to changes in temperature and equilibrium line altitude (ELA. Glacier volume reductions between −35 to −62% are possible by 2050, and sustained temperature increases to 2100 may result in total glacier volume losses of between −73 and −96%.

  1. Weather And Death On Mount Everest: An Analysis Of The Into Thin Air Storm.

    Science.gov (United States)

    Moore, G. W. K.; Semple, John L.

    2006-04-01

    Scientific interest in Mount Everest has been largely focused on the physiology of hypoxia caused by the summit's low barometric pressure. Although weather is recognized as a significant risk for climbers on the mountain, it has not been extensively studied. In this paper, we reconstruct the meteorological conditions associated with the deadly outbreak of high-impact weather on Mount Everest that occurred in May 1996 and was the subject of the best-selling book Into Thin Air. The authors show that during this event, two jet streaks—an upper-level short-wave trough and an intrusion of stratospheric air into the upper troposphere—were present in the vicinity of Mount Everest. Meanwhile, in the lower troposphere, there was convergence of water vapor transport from both the Arabian Sea and the Bay of Bengal into the region to the south of Mount Everest. The authors propose that the ageostrophic circulation associated with the upper-level features resulted in a region of large-scale ascent near Mount Everest that, in combination with the anomalous availability of moisture in the region, triggered convective activity. The resulting high-impact weather trapped over 20 climbers on Mount Everest's exposed upper slopes leading to the deaths of 8. These synoptic-scale characteristics provide some expectation of predicting life-threatening high-altitude storms in the Himalayas. In addition, the authors argue that the falling barometric pressure and the presence of ozone-rich stratospheric air that occurred near the summit of Mount Everest during this event could have shifted a coping climber from a state of brittle tolerance to physiological distress.

  2. In-situ observations of the April 2014 Mount Everest Avalanche

    Science.gov (United States)

    Moore, Kent; Cristofanelli, Paolo; Bonasoni, Paolo; Pietro Verza, Gian; Semple, John

    2016-04-01

    Instrumental records indicate a warming of approximately 0.8oC has occurred in the Everest region since the 1980s that has resulted in a 100-300m rise in the height at which the ground is permanently frozen as well as a retreat and thinning of Everest's glaciers. This period of warming has coincided with Mount Everest becoming an increasingly important destination for both climbers and trekkers. For some time, there have been concerns that this warming and the resultant changes in the region's glaciers may be increasing the risks for both travellers to Mount Everest as well as the indigenous populations who support them. On April 18 2014, an avalanche caused by the collapse of a large serac swept down Mount Everest's Khumbu Ice Fall resulting in the deaths of 16 Sherpa. Although satellite imagery has been used to estimate the size of the serac, in-situ data on the avalanche itself has not been available. Here we show that this event was of a sufficient size as to result in the excitation of a 20 min long 'avalanche wind' that was observed at the Nepal Climate Observatory-Pyramid situated 12 km from Mount Everest. We use these observations to estimate that the winds at Everest Base Camp during this event were of hurricane strength. As a result of the destabilization of the region's glaciers due to the climate change, there are concerns that such events may become more frequent. These results provide the basis for a method to estimate the frequency and severity of avalanches in this region.

  3. A population approach to renal replacement therapy epidemiology: lessons from the EVEREST study.

    Science.gov (United States)

    Caskey, Fergus J; Jager, Kitty J

    2014-08-01

    The marked variation that exists in renal replacement therapy (RRT) epidemiology between countries and within countries requires careful systematic examination if the root causes are to be understood. While individual patient-level studies are undoubtedly important, there is a complementary role for more population-level, area-based studies--an aetiological approach. The EVEREST Study adopted such an approach, bringing RRT incidence rates, survival and modality mix together with macroeconomic factors, general population factors and renal service organizational factors for up to 46 countries. This review considers the background to EVEREST, its key results and then the main methodological lessons and their potential application to ongoing work. PMID:24166464

  4. Climatological significance of an ice core net-accumulation record at Mt. Qomolangma (Everest)

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    An ice core record at Mt. Qomolangma (Everest) since 1954 reveals a sharp decline in net-accumulation in the 1960s, and the annual net-accumulation during the 1970s to the beginning of the 1990s is only half of that at the end of the 1950s. The decreased net-accumulation is coincident with glacier retreat, which is associated with recent temperature increase in the region that intensified the ablation. Under the background of global warming, such glacier variation trends will aggravate.

  5. [Diet for the first expedition of Soviet climbers to Mount Everest].

    Science.gov (United States)

    Belakovskiĭ, M S; Voskoboĭnikov, V A; Guliaev, V N; Zakharenko, T S; Senkevich, Iu A

    1984-01-01

    Biomedical requirements for the diets to be used by the Soviet mountaineers during their Everest expedition have been determined, employing the experience of Soviet mountaineers who have ascended the highest summits in this country, dietary data accumulated by the mountaineers who have conquered the Himalaya Mountains and the Karakoram Range, as well as current concepts of human physiology and biochemistry in highlands. This paper presents the major nutritional parameters of the diets and the arrangement of meals. The Soviet mountaineers were on the whole happy with the diets and showed no disorders in the health state, gastrointestinal system or digestive function that can be of nutritional origin.

  6. 23rd May 2011 - University of Liverpool Pro-Vice-Chancellor and Public Orator K. Everest (UK) Mrs Everest in the ATLAS visitor centre with Collaboration Deputy Spokesperson D. Charlton, in LHCb surface building with Collaboration Spokesperson A. Golutvin, accompanied throughout by P. Wells and Liverpool University T. Bowcock and M. Klein.

    CERN Document Server

    Maximilen Brice

    2011-01-01

    23rd May 2011 - University of Liverpool Pro-Vice-Chancellor and Public Orator K. Everest (UK) Mrs Everest in the ATLAS visitor centre with Collaboration Deputy Spokesperson D. Charlton, in LHCb surface building with Collaboration Spokesperson A. Golutvin, accompanied throughout by P. Wells and Liverpool University T. Bowcock and M. Klein.

  7. The dynamics of supraglacial water storage in the Everest region, central Himalaya

    Science.gov (United States)

    Watson, C. Scott; Quincey, Duncan J.; Carrivick, Jonathan L.; Smith, Mark W.

    2016-07-01

    The dynamics of supraglacial pond development in the Everest region are not well constrained at a glacier scale, despite their known importance for meltwater storage, promoting ablation, and transmitting thermal energy englacially during drainage events. Here, we use fine-resolution (~ 0.5-2 m) satellite imagery to reveal the spatiotemporal dynamics of 9340 supraglacial ponds across nine glaciers in the Everest region, ~ 2000-2015. Six of our nine study glaciers displayed a net increase in ponded area over their observation periods. However, large inter- and intra-annual changes in ponded area were observed of up to 17% (Khumbu Glacier), and 52% (Ama Dablam) respectively. Additionally, two of the fastest expanding lakes (Spillway and Rongbuk) partially drained over our study period. The Khumbu Glacier is developing a chain of connected ponds in the lower ablation area, which is indicative of a trajectory towards large lake development. We show that use of medium-resolution imagery (e.g. 30 m Landsat) is likely to lead to large classification omissions of supraglacial ponds, on the order of 15-88% of ponded area, and 77-99% of the total number of ponds. Fine-resolution imagery is therefore required if the full spectrum of ponds that exist on the surface of debris-covered glaciers are to be analysed.

  8. Microbial community structure in major habitats above 6000 m on Mount Everest

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Bacterial abundance in surface snow between 6600 and 8000 m a.s.l. On the northern slope of Mt. Everest was investigated by flow cytometry. Bacterial diversity in serac ice at 6000 m a.s.l., glacier meltwater at 6350 m, and surface snow at 6600 m a.s.l. Was examined by constructing a 16S rRNA gene clone library. Bacterial abundance in snow was higher than that in the Antarctic but similar to other mountain regions in the world. Bacterial abundance in surface snow increased with altitude but showed no correlation with chemical parameters. Bacteria in the cryosphere on Mt. Everest were closely related to those isolated from soil, aquatic environments, plants, animals, humans and other frozen environments. Bacterial community structures in major habitats above 6000 m were variable. The Cytophaga-Flavobacterium-Bacteroides (CFB) group absolutely dominated in glacial meltwater, while β-Proteobacteria and the CFB group dominated in serac ice, and β-Proteobacteria and Actinobacteria dominated in surface snow. The remarkable differences among the habitats were most likely due to the bacterial post-deposition changes during acclimation processes.

  9. Research on Unified Process Based on eXtreme Programming%基于极限编程的统一过程探讨

    Institute of Scientific and Technical Information of China (English)

    钟琪; 何俊梅; 张为群

    2004-01-01

    对统一过程(Unified Process,UP)、极限编程(eXtreme Programming,XP)进行了简要分析,结合这两者在软件开发中所表现出来的优点,提出了一种使用XP的自底向上方法对UP的自顶向下方法进行改进的方案.改进后的过程能在介于这两者规模之间的项目中进行灵活的应用.

  10. Measurements of radioactive and stable sulfur isotopes at Mt. Everest and its geochemical implications

    Science.gov (United States)

    Lin, M.; Thiemens, M. H.; Zhang, Q.; Li, C.; Kang, S.; Hsu, S. C.; Zhang, Z.; Su, L.

    2015-12-01

    The Himalayas were recently identified as a global hotspot for deep stratosphere-to-troposphere transport (STT) during spring [1]. Although STT transport in this region may play a vital role in tropospheric chemistry, the hydrological cycle and aquatic ecosystems in Asia, there is no direct measurement of a specific chemical stratospheric tracer to verify and evaluate its possible impact. Here, cosmogenic 35S tracer (half-life: ~87 days) produced in the stratosphere was measured for the first time in surface snow and river runoff samples collected at Mt. Everest in April 2013 using a low-noise liquid scintillation spectroscopy [2]. Strikingly, we find extraordinarily high concentrations of 35S in these samples (>10 times higher than the southern Tibetan Plateau), verifying the Himalayas as a gateway of springtime STT. In light of this, two studies were conducted: a) Measurements of 35SO2 and 35SO42- at the southern Tibetan Plateau reveals that the oxidative life time of SO2 is reduced to 2.1 days under the influence of aged stratospheric air masses from the Himalayas. A concept box model for estimating the influence of STT on surface O3 using 35S tracer is proposed. b) Quadruple stable sulfur isotopes in a sediment core (~250 years) from the Gokyo Lake (the world's highest freshwater lake) [3] near Mt. Everest are being measured to investigate the possible impact of STT on sulfur budget at the Himalayas. The absence of sulfide suggests that bacterial sulfate reduction may be negligible in this lake. Enrichment of uranium (EF ≈ 10) in 20th century samples highlights the impact of atmospheric deposition. S-isotope sulfate anomalies are not found (∆33S and ∆36S ≈ 0‰), implying that sulfate in this lake may be mainly contributed by eolian dust or derived from rock. This is also supported by the low enrichments of most trace elements (EF ≈ 1). Rare earth elements will be used to assist in identifying the potential sources and interpreting the variation of

  11. Visitor impacts on trails in the Sagarmatha (Mt. Everest) National Park, Nepal.

    Science.gov (United States)

    Nepal, Sanjay K; Nepal, Stella Amor

    2004-08-01

    This study summarizes findings of a visitor impact study conducted in the Sagarmatha (Mt. Everest) National Park, Nepal. The effect of visitor use, and the influence of environmental characteristics on trail conditions are investigated. Seven trails divided into 208 trail segments, and with a total length of 90 kilometers were included in the assessment. A four-class rating system has been used for the assessment of trail conditions. Arc/Info and Arc/View geographic information system (GIS) are used to analyze spatial patterns of impacts. The study indicates a strong correlation between visitor use and trail degradation. However, locational and environmental factors are equally important variables. The study concludes that more systematic, and experimental studies are needed that can make a clear distinction between human-induced trail damage and the effects of natural factors. PMID:15387069

  12. Seasonal features of aerosol particles recorded in snow from Mt. Qomolangma (Everest) and their environmental implications

    Institute of Scientific and Technical Information of China (English)

    CONG Zhiyuan; KANG Shichang; QIN Dahe

    2009-01-01

    To assess the seasonality of aerosol deposition and anthropogenic effects on central Himalayas, a 1.85-m deep snow pit was dug on the northern slope of Mr. Qomolangma (Everest). Based on the morphology and energy dispersive X-ray (EDX) signal, totally 1500 particles were classed into 7 groups: soot; aluminosilicates; fly ash; calcium sulfates; Ca/Mg carbonates; metal oxides; and biological particles and carbon fragments. The size distribution and number fractions of different particle groups exhibited distinct seasonal variations between non-monsoon and monsoon periods, which are clearly related to the differences in air mass pathways. Specifically, the relative abundance of soot in non-monsoon period (25%) was much higher than that in monsoon period (14%), indicating Mr. Qomolangma region received more anthropogenic influence in non-monsoon than monsoon period.

  13. Medicines, Travellers and the Introduction and Spread of ‘Modern’ Medicine in the Mt Everest Region of Nepal

    OpenAIRE

    Heydon, Susan

    2011-01-01

    The significant contribution of medicines in the introduction and spread of ‘modern’ medicine has, with the exception of vaccination, been neglected in historical studies, yet medicines have been a significant factor in people’s experiences of sickness and in their use and non-use of health services. Although medicines are implicitly acknowledged in the literature as important in the provision of healthcare, this article uses a case study of the Mt Everest region of Nepal during the second ha...

  14. Improving the scientific research for the Geohazard Supersites through a Virtual Research Environment: the H2020 EVER-EST Project

    Science.gov (United States)

    Trasatti, Elisa; Salvi, Stefano

    2016-04-01

    The EU's H2020 EVER-EST Project is dedicated to the realization of a Virtual Research Environment (VRE) for Earth Science researchers, during 2015-2018. EVER-EST implements innovative and state-of-the-art technologies in the area of Earth Science data catalogues, data access/processing and long-term data preservation together with models, techniques and tools for the computational methods, such as scientific workflows. The VRE is designed with the aim of providing the Earth Science user community with an innovative framework, enhancing their ability to interoperate and share knowledge and experience. Therefore, the VRE is user-centric and focuses the e-infrastructure capabilities in order to satisfy the needs of different Virtual Research Communities. Four use cases have been chosen to validate the e-infrastructure and the GEO Geohazard Supersites is one of them. EVER-EST will help the exploitation of the full potential of the GEO Geohazard Supersite and Natural Laboratories (GSNL) initiative demonstrating the use case in the Permanent Supersites of Mt Etna, Campi Flegrei-Vesuvius, and Icelandic volcanoes. Besides providing tools for active volcanoes monitoring and studies, we intend to demonstrate how a more organized and collaborative research environment, such as a VRE, can improve the quality of the scientific research on the Geohazard Supersites, addressing at the same time the problem of the slow uptake of scientific research findings in Disaster Risk Management. Presently, the full exploitation of the in situ and satellite data made available for each Supersite is delayed by the difficult access (especially for researchers in developing countries) to intensive processing and modelling capabilities. EVER-EST will provide these means and also a friendly virtual environment for the easy transfer of scientific knowledge as soon as it is acquired, promoting collaboration among researchers located in distant regions of the world. A further benefit will be to

  15. Progress in technology for the 2005 height determination of Qomolangma Feng (Mt. Everest)

    Institute of Scientific and Technical Information of China (English)

    CHEN; Junyong; YUAN; Janli; GUO; Chunxi; ZHANG; Yanping; ZHANG; Peng

    2006-01-01

    In 2005 China carried out a new geodetic campaign for the height determination of Qomolangma Feng--Mt. Everest (QF in short). The technical progresses in geodesy for the 2005 campaign are presented in the paper. GPS positioning was the key technique in the campaign. After summarizing the experiences and lessons of the GPS positioning on the QF summit in the previous QF height determination campaigns, some measures were taken to raise the accuracy and reliability of the height determination with GPS techniques. In order to raise the accuracy of the height determination of the QF summit with classical geodetic techniques, laser ranging was used together with the trigonometric levelling in the 2005 campaign. It is the first time in China the thickness of the ice-snow layer on the QF summit was measured by ground penetrating radar integrated with GPS. The local gravity field and geoid in the QF area was improved on the basis of earth gravity field model integrated with new ground gravity data, DTM data and GPS leveling data in the QF area. In the 2005 campaign the normal height and orthometric height (height above sea level) of the snow surface of the QF summit were obtained as 8846.67 m and 8847.93 m respectively. The orthometric height of the rock surface of the QF summit is 8844.43 m,and the thickness of the ice-snow layer on the QF summit is 3.50 m.

  16. 基于MapXtreme的雷电实时监测预警系统设计与实现%Design and Realization of Lightning Real-time Monitoring and Warning System Based on MapXtreme

    Institute of Scientific and Technical Information of China (English)

    马艳军; 吕爽; 方国强; 向继涛

    2011-01-01

    在MapXtreme结构的基础上,构建基于MapXtreme的雷电实时监测预警系统.该系统实现雷电探测站点运行状态和闪电数据的实时监控,查询历史闪电数据及根据过往闪电资料做出临近预报预警,该系统在四川省雷电业务分析中起了重要的作用.%Based on MapXtreme structure, a real-time monitoring and warning system of lightning based on MapXtreme is constructed. This system achieves real-time monitoring of lightning detection site running and lightning data, queries of historical lightning data, and makes now forecasting warning based on historical lightning data. The system plays an important role in Sichuan province lighting data analysis.

  17. Vpliv hipoksije na vedenjsko termoregulacijo - poročilo z odprave Si.mobil Ski Everest 2000: The effect of hypoxia on behavioural temperature regulation - report from the Si.mobil Ski Everest 2000 expedition:

    OpenAIRE

    Gorjanc, Jurij; Jaki, Polona; Mekjavić, Igor B.

    2002-01-01

    During the Si.mobil Ski Everest 2000 expedition the hypothesis that hypoxia affects temperature perception was tested. Subjects (N = 5), all members of the expedition, provided subjective ratings of temperature perception on a 7-point scale and thermal comfort on a 4-point scale at Base Camp (BC, 5360 m), Camp 1(C1, 6050 m), Camp 2 (C2, 6500 m), Camp 3 (C3, 7300 m) and Camp 4 (C4, 7950 m). In addition, we recorded oxygen saturation (SaO2, %), axilla temperature (Tax), and tympanic temperature...

  18. Thermal Resistances in the Everest Area derived from Satellite Imagery using a Nonlinear Energy Balance Model

    Science.gov (United States)

    Rounce, D.; McKinney, D. C.

    2013-12-01

    Debris cover has a large impact on sub-debris ablation rates and glacier evolution. A thin debris layer may enhance ablation by reducing albedo increasing radiation absorption, while thicker debris insulates the glacier causing ablation to decrease. Debris thickness, thermal conductivity, and meteorological conditions may be measured in the field, but they require extensive fieldwork (Brock et al., 2010; Nicholson and Benn, 2012). This has forced many simplifications and assumptions in models. Satellite imagery combined with an energy balance model has been used with to extract information about debris cover remotely (Nakawo and Rana, 1999; Zhang et al., 2011). The spatial distribution of thermal resistances derived from these studies have agreed well with field values; however, the values were considerably lower than the field values. The difference has been attributed to the mixed pixel effect. Foster et al. (2012) developed an energy balance model that agrees well with debris thickness measured in the field. The model requires knowledge of the thermal conductivity and utilizes a relationship between air and surface temperature to lower sensible heat fluxes. We derive thermal resistances of debris-covered glaciers from satellite imagery in the Everest area. Previous satellite studies have assumed a linear debris temperature gradient, which is valid for time periods of 24 hours or greater (Nicholson and Benn, 2006); however, gradients during the day are nonlinear (Nicholson and Benn, 2006; Reid and Brock, 2010). Landsat 7 imagery is used to account for the non-linear gradient, using the ratio of temperature gradient in the upper 10cm versus the entire debris thickness. These values are derived from temperature profiles on Ngozumpa Glacier (Nicholson, 2004). Meteorological data are obtained from the Pyramid Station. The derived thermal resistances agree well with those found on debris-covered glaciers in the Everest region. Brock, B., Mihalcea, C., Kirkbride, M

  19. Meteorological Features at 6523 m of Mt. Qomolangma (Everest) between 1 May and 22 July 2005

    Institute of Scientific and Technical Information of China (English)

    XIE Aihong; REN Jiawen; QIN Xiang; JIANG Youyan

    2006-01-01

    Mt. Qomolangma (Everest), the highest mountain peak in the world, has little been studied extensively from a meteorological perspective, mostly because of the remoteness of the region and the resultant lack of meteorological data. An automatic weather station (AWS), the highest in the world, was set up on 27 April 2005 at the Ruopula Pass (6523 m asl) on the northern slope of Mt. Qomolangma by the team of integrated scientific expedition to Mt. Qomolangma. Here its meteorological characteristics were analyzed according to the 10-minute-averaged and 24-hour records of air temperature, relative humidity,air pressure and wind from 1 May to 22 July 2005. It is shown that at 6523 m of Mt. Qomolangma, these meteorological elements display very obvious diurnal variations, and the character of averaged diurnal variation is one-peak-and-one-vale for air temperature, one-vale for relative humidity, two-peak-and-two-vale for air pressure, and one-peak with day-night asymmetry for wind speed. In the 83 days,all the air temperature, relative humidity and air pressure increased with some different fluctuations,while wind speed decreased gradually and wind direction turned from north to south. The variations of relative humidity had great fluctuations and obvious local differences. Then the paper discusses the reason for the characters of diurnal and daily variations.Compared with the corresponding records in May 1960, 5-day-averaged maximums, minimums and diurnal variations of air temperature in May 2005 were apparently lower.

  20. Percutaneous vertebroplasty: Multi-centric results from EVEREST experience in large cohort of patients

    Energy Technology Data Exchange (ETDEWEB)

    Anselmetti, Giovanni Carlo, E-mail: giovanni.anselmetti@ircc.it [Interventional Radiology Unit, Institute for Cancer Research and Treatment, Strada Provinciale No. 142, Km. 3, 95, 10060 Candiolo, Turin (Italy); Marcia, Stefano, E-mail: stemarcia@gmail.com [Radiology Unit, ASL8 Cagliari, SS. Trinità Hospital, Via Is Mirrionis 92, 09121 Cagliari (Italy); Saba, Luca, E-mail: lucasaba@tiscali.it [Radiology Unit, University of Cagliari, Policlinico Universitario, ss 554, Monserrato, 09127 Cagliari (Italy); Muto, Mario, E-mail: mutomar@tiscali.it [Neuroradiology Unit, AORN Cardarelli, Via A. Cardarelli No. 9, 80131 Napoli (Italy); Bonaldi, Giuseppe, E-mail: bonaldi@mail.org [Neuroradiology Unit, Riuniti di Bergamo, Largo Barozzi, 124128 Bergamo (Italy); Carpeggiani, Paolo, E-mail: p.carpeggiani@ausl.mo.it [Neuroradiology Unit, Policlinico di Modena, Via Dal Pozzo 17, Modena (Italy); Marini, Stefano, E-mail: stemarini@gmail.com [Radiology Unit, University of Cagliari, San Giovanni di Dio Hospital, Via Ospedale 46, 09127 Cagliari (Italy); Manca, Antonio, E-mail: anto.manca@gmail.com [Interventional Radiology Unit, Institute for Cancer Research and Treatment, Strada Provinciale No. 142, Km. 3, 95, 10060 Candiolo, Turin (Italy); Masala, Salvatore, E-mail: salva.masala@tiscali.it [Radiology Unit, Diagnostic Imaging Department, University of Rome Tor Vergata, Roma (Italy)

    2012-12-15

    Purpose: The purpose of this study was to prospectively evaluate results and complications of percutaneous vertebroplasty (PV) performed in 6 different Italian Centres belonging to the European VErtebroplasty RESearch Team (E.VE.RES.T) in a large series of patients. Materials and methods: Follow-up was obtained in 4547 patients (3211 females and 1336 males; mean age 70.2 years) that underwent PV for a total of 13.437 treated vertebrae. Procedures were performed by using fluoroscopic guidance or combined CT-fluoroscopic guidance. All patients underwent PV in local anaesthesia except for second cervical vertebrae treated with a trans-oral approach that required general anaesthesia. Results: 4004 out of 4547 (88.0%) patients reported significant pain relief (difference > or = 2 point in pain evaluated with an 11-point visual analogue scale; p < 0.0001) within 48 h: an average of 7.7 ± 0.4 dropped to 1.8 ± 0.6 in the osteoporotic patients; 8.3 ± 0.4 to 2.4 ± 0.4 in metastases; 8.3 ± 0.4 to 1.7 ± 1.0 in myeloma; 6.2 ± 3.5 to 0.3 ± 0.2 in angioma and 7.4 ± 0.4 to 1.4 ± 0.9 in trauma. 430 osteoporotic patients (13%) were retreated for a subsequent fracture; in 302/430 patients (70.2%), the new fracture occurred in the contiguous vertebra. No major neurologic complications were reported and the most frequent minor complication was venous leakage (20.5%). Conclusions: This large series of patients confirms that percutaneous vertebroplasty is an effective and safe procedure in the treatment of vertebral fractures. Best results are obtained in the treatment of myeloma and trauma.

  1. Rongbuk re-visited: Geochronology of leucogranites in the footwall of the South Tibetan Detachment System, Everest Region, Southern Tibet

    Science.gov (United States)

    Cottle, John M.; Searle, Michael P.; Jessup, Micah J.; Crowley, James L.; Law, Richard D.

    2015-06-01

    The Hermit's Gorge area adjacent to the Rongbuk Glacier on the north side of Mount Everest is a critical location to establish the timing and duration of movement along the ductile strand of the South Tibetan Detachment system (STDS), a low-angle, north-dipping normal fault that bounds the upper part of the Greater Himalayan Sequence. Monazite from four leucogranite samples in the Hermit's Gorge that bracket the timing of ductile fabric development has been dated using both U/Th-Pb ID-TIMS and LA-MC-ICPMS. Results suggest that the earliest, ~ 16.4 Ma, leucogranite sills have been folded and deformed along with the host sillimanite gneisses and calc-silicates whereas structurally higher sills and dykes that post-date fabric development are slightly younger, all within uncertainty of one another at 15.6 to 15.4 Ma. Field relations combined with age data constrain ductile fabric formation associated with movement along this strand of the STDS as being on-going at 16.4 Ma but had ceased prior to 15.6 Ma, while brittle faulting along the STDS is younger than 15.4 Ma. Combined with data from the Everest massif and surrounding region, ages of granite crystallization and ductile shearing propagated up-structural section and northward with time.

  2. SPHERE eXtreme AO control scheme: final performance assessment and on sky validation of the first auto-tuned LQG based operational system

    Science.gov (United States)

    Petit, C.; Sauvage, J.-F.; Fusco, T.; Sevin, A.; Suarez, M.; Costille, A.; Vigan, A.; Soenke, C.; Perret, D.; Rochat, S.; Barrufolo, A.; Salasnich, B.; Beuzit, J.-L.; Dohlen, K.; Mouillet, D.; Puget, P.; Wildi, F.; Kasper, M.; Conan, J.-M.; Kulcsár, C.; Raynaud, H.-F.

    2014-08-01

    The SPHERE (Spectro-Polarimetry High-contrast Exoplanet Research) instrument is an ESO project aiming at the direct detection of extra-solar planets. SPHERE has been successfully integrated and tested in Europe end 2013 and has been re-integrated at Paranal in Chile early 2014 for a first light at the beginning of May. The heart of the SPHERE instrument is its eXtreme Adaptive Optics (XAO) SAXO (SPHERE AO for eXoplanet Observation) subsystem that provides extremely high correction of turbulence and very accurate stabilization of images for coronagraphic purpose. However, SAXO, as well as the overall instrument, must also provide constant operability overnights, ensuring robustness and autonomy. An original control scheme has been developed to satisfy this challenging dichotomy. It includes in particular both an Optimized Modal Gain Integrator (OMGI) to control the Deformable Mirror (DM) and a Linear Quadratic Gaussian (LQG) control law to manage the tip-tilt (TT) mirror. LQG allows optimal estimation and prediction of turbulent angle of arrival but also of possible vibrations. A specific and unprecedented control scheme has been developed to continuously adapt and optimize LQG control ensuring a constant match to turbulence and vibrations characteristics. SPHERE is thus the first operational system implementing LQG, with automatic adjustment of its models. SAXO has demonstrated performance beyond expectations during tests in Europe, in spite of internal limitations. Very first results have been obtained on sky last May. We thus come back to SAXO control scheme, focusing in particular on the LQG based TT control and the various upgrades that have been made to enhance further the performance ensuring constant operability and robustness. We finally propose performance assessment based on in lab performance and first on sky results and discuss further possible improvements.

  3. Plan for proposed aquifer hydraulic testing and groundwater sampling at Everest, Kansas, in January-February 2006.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2006-01-31

    On September 8-9, 2005, representatives of the Kansas Department of Health and Environment (KDHE), the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA), and Argonne National Laboratory met at the KDHE's offices in Topeka to review the status of the CCC/USDA's environmental activities in Kansas. A key CCC/USDA goal for this meeting was to obtain KDHE input on the selection of possible remedial approaches to be examined as part of the Corrective Action Study (CAS) for this site. As a result of the September meeting, the KDHE recommended several additional activities for the Everest site, to further assist in selecting and evaluating remedial alternatives for the CAS. The requested actions included the following: (1) Construction of several additional interpretive cross sections to improve the depiction of the hydrogeologic characteristics affecting groundwater and contaminant movement along the apparent main plume migration pathway to the north-northwest of the former CCC/USDA facility, and in the vicinity of the Nigh property. (2) Identification of potential locations for several additional monitoring wells, to better constrain the apparent western and northwestern margins of the existing groundwater plume. (3) Development of technical recommendations for a stepwise pumping study of the Everest aquifer unit in the area near and to the north of the Nigh property. On October 21, 2005, Argonne issued a brief Cross Section Analysis (Argonne 2006a) addressing these concerns, on behalf of the CCC/USDA. This report includes the following: (1) Preliminary recommendations for the siting of three new monitoring wells, at locations identified by the KDHE. Argonne also suggested, however, that the installation and sampling of these wells be deferred until after completion of the CAS evaluation. (2) A proposed strategy for testing of the Everest aquifer unit near the Nigh property, involving initial test pumping of the former Nigh domestic

  4. Practice and Search of Agile Development and eXtreme Programming in Developing Management Information System%敏捷开发-XP在管理信息系统中实践与研究

    Institute of Scientific and Technical Information of China (English)

    黄志明

    2009-01-01

    极限编程XP(eXtreme Programming)是敏捷开发的代表,是一个混乱而有序的、基于实践的软件开发方法.通过介绍极限编程的特点及其在某信息管理系统中的应用,探讨研究了极限编程在中小型需求易变的信息管理系统开发项目的实际运用和实践总结.

  5. 一种基于极限编程的实验室项目软件方法LabXP%An eXtreme Programming Based Laboratory Project Software Methodology--LabXP

    Institute of Scientific and Technical Information of China (English)

    邵飞; 葛季栋; 胡昊; 鲍钦迪; 吕建

    2005-01-01

    本文基于一种敏捷的软件方法--极限编程,结合实验室项目的特点,探讨了在实验室项目中进行软件开发的方法,提出了一种实验室项目软件方法LabXP(Lab eXtreme Programing).鉴于实验室项目的特殊性,这种方法是以极限编程(XP)为基础的敏捷软件方法(Agile Software Method),在保证软件质量的基础上实现了快速开发.

  6. Future hydrological regimes and glacier cover in the Everest region: The case study of the upper Dudh Koshi basin.

    Science.gov (United States)

    Soncini, Andrea; Bocchiola, Daniele; Confortola, Gabriele; Minora, Umberto; Vuillermoz, Elisa; Salerno, Franco; Viviano, Gaetano; Shrestha, Dibas; Senese, Antonella; Smiraglia, Claudio; Diolaiuti, Guglielmina

    2016-09-15

    Assessment of future water resources under climate change is required in the Himalayas, where hydrological cycle is poorly studied and little understood. This study focuses on the upper Dudh Koshi river of Nepal (151km(2), 4200-8848ma.s.l.) at the toe of Mt. Everest, nesting the debris covered Khumbu, and Khangri Nup glaciers (62km(2)). New data gathered during three years of field campaigns (2012-2014) were used to set up a glacio-hydrological model describing stream flows, snow and ice melt, ice cover thickness and glaciers' flow dynamics. The model was validated, and used to assess changes of the hydrological cycle until 2100. Climate projections are used from three Global Climate Models used in the recent IPCC AR5 under RCP2.6, RCP4.5 and RCP8.5. Flow statistics are estimated for two reference decades 2045-2054, and 2090-2099, and compared against control run CR, 2012-2014. During CR we found a contribution of ice melt to stream flows of 55% yearly, with snow melt contributing for 19%. Future flows are predicted to increase in monsoon season, but to decrease yearly (-4% vs CR on average) at 2045-2054. At the end of century large reduction would occur in all seasons, i.e. -26% vs CR on average at 2090-2099. At half century yearly contribution of ice melt would be on average 45%, and snow melt 28%. At the end of century ice melt would be 31%, and snow contribution 39%. Glaciers in the area are projected to thin largely up to 6500ma.s.l. until 2100, reducing their volume by -50% or more, and their ice covered area by -30% or more. According to our results, in the future water resources in the upper Dudh Koshi would decrease, and depend largely upon snow melt and rainfall, so that adaptation measures to modified water availability will be required.

  7. The effect of climbing Mount Everest on spleen contraction and increase in hemoglobin concentration during breath holding and exercise.

    Science.gov (United States)

    Engan, Harald K; Lodin-Sundström, Angelica; Schagatay, Fanny; Schagatay, Erika

    2014-04-01

    Release of stored red blood cells resulting from spleen contraction improves human performance in various hypoxic situations. This study determined spleen volume resulting from two contraction-evoking stimuli: breath holding and exercise before and after altitude acclimatization during a Mount Everest ascent (8848 m). Eight climbers performed the following protocol before and after the climb: 5 min ambient air respiration at 1370 m during rest, 20 min oxygen respiration, 20 min ambient air respiration at 1370 m, three maximal-effort breath holds spaced by 2 min, 10 min ambient air respiration, 5 min of cycling at 100 W, and finally 10 min ambient air respiration. We measured spleen volume by ultrasound and capillary hemoglobin (HB) concentration after each exposure, and heart rate (HR) and arterial oxygen saturation (Sao2) continuously. Mean (SD) baseline spleen volume was unchanged at 213 (101) mL before and 206 (52) mL after the climb. Before the climb, spleen volume was reduced to 184 (83) mL after three breath holds, and after the climb three breath holds resulted in a spleen volume of 132 (26) mL (p=0.032). After exercise, the preclimb spleen volume was 186 (89) mL vs. 112 (389) mL) after the climb (p=0.003). Breath hold duration and cardiovascular responses were unchanged after the climb. We concluded that spleen contraction may be enhanced by altitude acclimatization, probably reflecting both the acclimatization to chronic hypoxic exposure and acute hypoxia during physical work. PMID:24673535

  8. Thermochronologic constraints on the Miocene slip history of the South Tibetan detachment system in the Everest region, central Himalaya

    Science.gov (United States)

    Schultz, M.; Hodges, K. V.; Van Soest, M. C.; Wartho, J. A.

    2014-12-01

    North-dipping, low-angle normal faults of the South Tibetan detachment system (STDS) can be traced for a distance of more than 2000 km along strike and represent an important tectonic characteristic of the Miocene Himalayan-Tibetan orogenic system. Nowhere is the STDS better exposed than the N-S-trending Rongbuk Valley in southern Tibet, where it can be traced down dip from the summit of Everest for a distance of over 30 km before disappearing beneath the valley floor. This places a minimum constraint on Miocene displacement on the feature in this area, but some research groups have suggested ~200 km of displacement based on the difference in metamorphic pressures across the STDS and the very low (sillimanite gneisses and leucogranites. Data obtained thus far indicate relatively rapid cooling of the footwall after the intrusion of deformed leucogranites at ca. 16.7 Ma to muscovite 40Ar/39Ar closure temperatures (ca. 15.5-14.2 Ma) and zircon (U-Th)/He closure temperatures (ca. 14.5-11 Ma). We attribute this cooling to tectonic denudation related to ca. 16 Ma STDS slip. Although the (U-Th)/He systematics of apatites from these rocks is complex, our current interpretation of available data places cooling through the ca. 75˚C closure isotherm at ca. 8-9 Ma, which would suggest a significant reduction in cooling rate that is observed in our inverse model runs of the 1D program, HeFTy. Ongoing analyses of footwall samples from ~8 km to the north of our Rongbuk sample localities in the Ra Chu river valley will greatly strengthen our datasets. With the Ra Chu analyses, our datasets will constrain the cooling history of the footwall for more than 20 km perpendicular to the strike of the detachment. Our presentation will also incorporate results from the program Pecube that will contribute to our calculation of the slip rate by specifying the appropriate exhumation rate.

  9. Debris-covered energy balance model for Imja-Lhotse Shar Glacier in the Everest region of Nepal

    Directory of Open Access Journals (Sweden)

    D. R. Rounce

    2015-06-01

    Full Text Available Debris thickness plays an important role in regulating ablation rates on debris-covered glaciers as well as controlling the likely size and location of supraglacial lakes. Despite its importance, lack of knowledge about debris properties and associated energy fluxes prevents the robust inclusion of the effects of a debris layer into most glacier surface energy balance models. This study combines fieldwork with a debris-covered energy balance model to estimate debris temperatures and ablation rates on Imja-Lhotse Shar glacier located in the Everest region of Nepal. The debris properties that significantly influence the energy balance model are thermal conductivity, albedo, and surface roughness. Fieldwork was conducted to measure thermal conductivity and a method was developed using Structure from Motion to estimate surface roughness. Debris temperatures measured during the 2014 melt season were used to calibrate and validate a debris-covered energy balance model by optimizing the albedo, thermal conductivity, and surface roughness at 10 debris-covered sites. Furthermore, three methods for estimating the latent heat flux were investigated. Model calibration and validation found the three methods had similar performance; however, comparison of modeled and measured ablation rates revealed that assuming a zero latent heat flux may overestimate ablation. Results also suggest that where debris moisture is unknown, measurements of the relative humidity or precipitation may be used to estimate wet debris periods, i.e., the latent heat flux is non-zero. The effect of temporal resolution on the model was also assessed and results showed that both 6 h data and daily average data slightly underestimate debris temperatures and ablation rates, thus these should only be used to estimate rough ablation rates when no other data are available.

  10. POP and PAH contamination in the southern slopes of Mt. Everest (Himalaya, Nepal): Long-range atmospheric transport, glacier shrinkage, or local impact of tourism?

    Science.gov (United States)

    Guzzella, Licia; Salerno, Franco; Freppaz, Michele; Roscioli, Claudio; Pisanello, Francesca; Poma, Giulia

    2016-02-15

    Due to their physico-chemical properties, POPs and PAHs are subjected to long-range atmospheric transport (LRAT) and may be deposited in remote areas. In this study, the contamination with DDx, PCBs, PBDEs, and PAHs was investigated in sediments and soils collected on the southern slopes of Mt. Everest (Himalaya, Nepal) in two different sampling campaigns (2008 and 2012). The results showed a limited contamination with POPs and PAHs in both soil and sediment samples. Therefore, the southern slopes of Mt. Everest can be considered a remote area in almost pristine condition. The LRAT mechanism confirmed its primary role in the transfer of contaminants to remote regions, while the gradual melting of glaciers, due to global warming, and the subsequent release of contaminants was suggested to be a secondary source of pollution of the lake sediments. In addition, the increase of tourism in this area during the last decades might have influenced the present concentrations of PAHs in the sediments and soils. PMID:26657383

  11. Warmed winters and weakened precipitation on Mt. Everest (central southern Himalaya) impacts glaciers, lakes, permafrost, and river discharges

    Science.gov (United States)

    Salerno, F.; Guyennon, N.; Thakuri, S.; Freppaz, M.; Balestrini, R.; Vuillermoz, E.; Tartari, G.

    2014-12-01

    This contribution aims linking temperature and precipitation patterns detected at high elevation of south slopes of Mt. Everest with a) glacier and lake surfaces, b) altitude limit of permafrost, c) frequency of daily river discharges. The study is carried out though: a) the daily temperature and precipitation reconstruction of the last twenty years (1994-2013) at 5050 m a.s.l. and 25 AWSs located at lower elevation and on Tibetan Plateau b) glacier surfaces (about 400 km2) and lake areas (more than 100 lakes) since 60s using all available satellite imagery c) permafrost distribution carried out with soil temperature measurements (2010-2012) compared with previous studies (70s) d) the results of a stochastic frequency model (wavelet analysis) for detecting river discharge changes in frequency of the Dud Koshi River basin (3000 km2) since 60s. We observed an increasing temperature trend occurred mainly in winter months, but during the summer ones we observed a slight decreasing of maximum temperature. We confirm for these high elevations the generalized weakening of the monsoon already observed in literature accounting here over 50% of reduction in the last 20 years! In the previous period (70s to 90s) gridded an reanalysis data revealed for our reference site a slighter increase of mean temperature and weak increase of precipitation. Main climate change driven implications: - The accelerated shrinkage of glaciers observed in the last twenty years, usually inferred to the temperature increase during the summer months, is ascribed here mainly to the regional monsoon weakening. - Supraglacial lakes confirm the acceleration of the negative mass balance of glaciers due to reduced ice velocities caused by decreased precipitation. - Unconnected lakes confirms precisely the observed precipitation trend. - The altitudinal limit of the permanent permafrost seems to be unchanged since the beginning '90s (probably due to stationary summer temperature). - Rivers discharges

  12. Estimates of land surface heat fluxes of the Mt. Everest region over the Tibetan Plateau utilizing ASTER data

    Science.gov (United States)

    Han, Cunbo; Ma, Yaoming; Chen, Xuelong; Su, Zhongbo

    2016-02-01

    Regional land surface albedo, land surface temperature, net radiation flux, ground heat flux, sensible heat flux, and latent heat flux were derived in the Mt. Everest area utilizing topographical enhanced surface energy balance system (TESEBS) model and nine scenes of ASTER (Advanced Spaceborne Thermal Emission and Reflection Radiometer) data under clear-sky and in-situ measurements at the QOMS station (the Qomolangma Station for Atmospheric Environmental Observation and Research, Chinese Academy of Sciences). The parameterization schemes for diffused and reflected downward shortwave radiation flux of the TESEBS model were improved by introducing the parameters sky-view factor (SVF) and terrain configuration factor (Ct). Then, a so-called C-correction method for land surface albedo was coupled into the TESEBS model to reduce the influences of topography. After topographical correction, the albedo of the dark tilted surface facing away from the Sun was compensated and albedo of the brightness surface facing the Sun was restrained. The downward shortwave radiation flux was broken down into three components including solar direct radiation flux, solar diffused radiation flux, and reflected solar radiation flux by surrounding terrain. The solar diffused radiation flux ranges from about 30 to 60 W/m2 at the satellite passing time on 6 January 2008. The reflected solar radiation flux changes from 0 to more than 100 W/m2 in the area covered by glaciers and snows. Thus, it is important to take the topographical effects into account in estimation of surface radiation balance in the mountainous area, especially in the glacier area. The retrieved land surface parameters, land surface radiation balance components, and the land surface energy balance components were evaluated by the field measurements in the QOMS station. The estimated results were very close to the in-situ observations with low mean bias errors, low root mean square errors and high correlation coefficients

  13. Isotopic signatures for natural versus anthropogenic Pb in high-altitude Mt. Everest ice cores during the past 800 years

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Khanghyun; Hur, Soon Do [Korea Polar Research Institute, Songdo Techno Park, 7-50, Songdo-dong, Yeonsu-gu, Incheon 406-840 (Korea, Republic of); Hou, Shugui [State Key Laboratory of Cryospheric Science, Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Science, Lanzhou 730000 (China); School of Geographic and Oceanographic Sciences, Nanjing University, Nanjing 210093 (China); Burn-Nunes, Laurie J. [Department of Imaging and Applied Physics, Curtin University of Technology, GPO Box U1987, Perth, WA 6845 (Australia); Hong, Sungmin, E-mail: smhong@inha.ac.kr [Department of Ocean Sciences, Inha University, 253 Yonghyun-dong, Nam-gu, Incheon, 402-751 (Korea, Republic of); Barbante, Carlo [Department of Environmental Sciences, University Ca' Foscari of Venice, Dorsoduro 2137, 30 123 Venice (Italy); Institute for the Dynamics of Environmental Processes-CNR, University Ca' Foscari of Venice, Dorsoduro 2137, 30 123 Venice (Italy); Boutron, Claude F. [Laboratoire de Glaciologie et Geophysique de l' Environnement (UMR Universite Joseph Fourier/CNRS 5183 ), 54 rue Moliere, BP 96, 38402 Saint Martin d' Heres Cedex (France); Unite de Formation et de Recherche ' Physique, Ingenierie, Terre, Environnement, Mecanique' , Universite Joseph Fourier de Grenoble ( Institut Universitaire de France ), 715 rue de la Houille Blanche, BP 53, 38041 Grenoble Cedex 9 (France); Rosman, Kevin J.R. [Department of Imaging and Applied Physics, Curtin University of Technology, GPO Box U1987, Perth, WA 6845 (Australia)

    2011-12-15

    A long-term record, extending back 800 years (1205 to 2002 AD), of the Pb isotopic composition ({sup 206}Pb/{sup 207}Pb and {sup 208}Pb/{sup 207}Pb) as well as Pb concentrations from high altitude Mt. Everest ice cores has the potential to identify sources and source regions affecting natural and anthropogenic Pb deposition in central Asia. The results show that the regional natural background Pb isotope signature ({approx} 1.20 for {sup 206}Pb/{sup 207}Pb and {approx} 2.50 for {sup 208}Pb/{sup 207}Pb) in the central Himalayas was dominated by mineral dust over the last {approx} 750 years from 1205 to 1960s, mostly originating from local sources with occasional contributions of long-range transported dust probably from Sahara desert and northwestern India. Since the 1970s, the Pb isotope ratios are characterized by a continuous decline toward less radiogenic ratios with the least mean ratios of 1.178 for {sup 206}Pb/{sup 207}Pb and 2.471 for {sup 208}Pb/{sup 207}Pb in the period 1990-1996. The depression of the {sup 206}Pb/{sup 207}Pb and {sup 208}Pb/{sup 207}Pb values during the corresponding periods is most likely due to an increasing influence of less radiogenic Pb of anthropogenic origin mainly from leaded gasoline used in South Asia (India as well as possibly Bangladesh and Nepal). From 1997 to 2002, isotopic composition tends to show a shift to slightly more radiogenic signature. This is likely attributed to reducing Pb emissions from leaded gasoline in source regions, coinciding with the nationwide reduction of Pb in gasoline and subsequent phase-out of leaded gasoline in South Asia since 1997. An interesting feature is the relatively high levels of Pb concentrations and enrichment factors (EF) between 1997 and 2002. Although the reason for this feature remains uncertain, it would be probably linked with an increasing influence of anthropogenic Pb emitted from other sources such as fossil fuel combustion and non-ferrous metal production.

  14. Future hydrological regimes and glacier cover in the Everest region: The case study of the upper Dudh Koshi basin.

    Science.gov (United States)

    Soncini, Andrea; Bocchiola, Daniele; Confortola, Gabriele; Minora, Umberto; Vuillermoz, Elisa; Salerno, Franco; Viviano, Gaetano; Shrestha, Dibas; Senese, Antonella; Smiraglia, Claudio; Diolaiuti, Guglielmina

    2016-09-15

    Assessment of future water resources under climate change is required in the Himalayas, where hydrological cycle is poorly studied and little understood. This study focuses on the upper Dudh Koshi river of Nepal (151km(2), 4200-8848ma.s.l.) at the toe of Mt. Everest, nesting the debris covered Khumbu, and Khangri Nup glaciers (62km(2)). New data gathered during three years of field campaigns (2012-2014) were used to set up a glacio-hydrological model describing stream flows, snow and ice melt, ice cover thickness and glaciers' flow dynamics. The model was validated, and used to assess changes of the hydrological cycle until 2100. Climate projections are used from three Global Climate Models used in the recent IPCC AR5 under RCP2.6, RCP4.5 and RCP8.5. Flow statistics are estimated for two reference decades 2045-2054, and 2090-2099, and compared against control run CR, 2012-2014. During CR we found a contribution of ice melt to stream flows of 55% yearly, with snow melt contributing for 19%. Future flows are predicted to increase in monsoon season, but to decrease yearly (-4% vs CR on average) at 2045-2054. At the end of century large reduction would occur in all seasons, i.e. -26% vs CR on average at 2090-2099. At half century yearly contribution of ice melt would be on average 45%, and snow melt 28%. At the end of century ice melt would be 31%, and snow contribution 39%. Glaciers in the area are projected to thin largely up to 6500ma.s.l. until 2100, reducing their volume by -50% or more, and their ice covered area by -30% or more. According to our results, in the future water resources in the upper Dudh Koshi would decrease, and depend largely upon snow melt and rainfall, so that adaptation measures to modified water availability will be required. PMID:27262982

  15. The Sea Monitoring Virtual Research Community (VRC) in the EVER-EST Project (a virtual research environment for the Earth Sciences).

    Science.gov (United States)

    Foglini, Federica; Boero, Ferdinando; Guarino, Raffaele

    2016-04-01

    The EU's H2020 EVER-EST Project is dedicated to the realization of a Virtual Research Environment (VRE) for Earth Science researchers during 2015-2018. In this framework the Sea monitoring represents one of the four use case VRCs chosen to validate the EVER-EST e-infrastructure, which is aimed at representing a wide and multidisciplinary Earth Science domain. The objective of the Sea Monitoring Virtual Research Community (VRC) is to provide useful and applicable contributions to the identification and definition of variables indicated by the European Commission in the Marine Directive under the framework for Good Environment Status (GES). The European Marine Strategy Framework Directive (MSFD, http://ec.europa.eu/environment/marine/index_en.htm) has defined the descriptors for Good Environmental Status in marine waters. The first descriptor is biodiversity; the second one is the presence of non-indigenous species while the remaining nine (even when they consider physical, chemical or geological variables) require proper functioning of the ecosystem, linked to a good state of biodiversity. The Sea Monitoring VRC is direct to provide practical methods, procedures and protocols to support coherent and widely accepted interpretation of the Descriptors 1(Biodiversity), 2 (non- indigenous species), 4 (food webs) and 6 (seafloor integrity) identified in GES. In that context, the criteria and methodological standards already identified by the European Commission, and at same time considering the activities and projects in progress in the marine framework, will be taken into account. This research of practical methods to estimate and measure GES parameters requires a close cooperation among different disciplines including: biologists, geologists, geophysics, oceanographers, Earth observation experts and others. It will also require a number of different types of scientific data and observations (e.g. biology related, chemico-physical, etc.) from different inputs and sensors

  16. Climatic significance of δ18O records from an 80.36 m ice core in the East Rongbuk Glacier, Mount Qomolangma (Everest)

    Institute of Scientific and Technical Information of China (English)

    ZHANG; Dongqi; QIN; Dahe; HOU; Shugui; KANG; Shichang; REN

    2005-01-01

    The δ18O variations in an 80.36 m ice core retrieved in the accumulation zone of the East Rongbuk Glacier, Mount Qomolangma (Everest), is not consistent with changes of air temperature from both southern and northern slopes of Himalayas, as well as these of the temperature anomalies over the Northern Hemisphere. The negative relationship between the δ18O and the net accumulation records of the ice core suggests the "amount effect" of summer precipitation on the δ18O values in the region. Therefore, the δ18O records of the East Rongbuk ice core should be a proxy of Indian Summer Monsoon intensity, which shows lower δ18O values during strong monsoon phases and higher values during weak phases.

  17. European Program 'EVEREST'. Evaluation of the elements producing the effective doses associated to a radioactive waste disposal in deep underground geological formations. Comparative study of the results obtained by IPSN concerning the sedimentary and granite formations

    International Nuclear Information System (INIS)

    The European exercise EVEREST that was run from 1991 to 1995 was a means of training for IPSN, having in view the expertise studies of ANDRA on the safety of radioactive waste geological disposal. The exercise implied two fictitious waste disposal sites, one inside a granite massif and the other in a clay formation, and had as principal objective identification and establishing a hierarchy of the radiological risk parameters important after the disposal closing. The study has considered the most likely scenario for evolution of the geological environment. As computing tools three codes were utilized: MELODIE, assuming a continuous 2D water flow and transfer of radionuclides from waste disposal to biosphere; TRISEC, assuming a continuous 3D water flow and NEWSAM, assuming a transient water flow in a multi-shell geometry. Results for the water circulation in different geological environment as well as the flux curves of soluble radionuclides are presented. Twenty seven radionuclides were retained as important by their radiological impact in assessing the influential EVEREST parameters. The EVEREST exercise does not prove the feasibility of a given geological disposal. It only contributes to the comprehension of the mechanisms controlling the radionuclide migration and gives a hierarchy of the questions which IPSN must answer in approaching the safety demonstrations required by ANDRA

  18. European Program 'EVEREST'. Evaluation of the elements producing the effective doses associated to a radioactive waste disposal in deep underground geological formations. Comparative study of the results obtained by IPSN concerning the sedimentary and granite formations; Programme europeen 'EVEREST'. Evaluation des elements responsables des doses efficaces associees a un stockage de dechets radioactifs en formations geologiques profondes. Etude comparative des resultats obtenus par l'IPSN concernant les formations sedimentaire et granitique

    Energy Technology Data Exchange (ETDEWEB)

    Baudoin, Patrick; Serres, Christophe; Certes Catherine [Departement d' evaluation de surete, Inst. de Protection et de Surete Nucleaire, CEA Centre d' Etudes de Fontenay-aux-Roses, 92 (France)

    1996-09-01

    The European exercise EVEREST that was run from 1991 to 1995 was a means of training for IPSN, having in view the expertise studies of ANDRA on the safety of radioactive waste geological disposal. The exercise implied two fictitious waste disposal sites, one inside a granite massif and the other in a clay formation, and had as principal objective identification and establishing a hierarchy of the radiological risk parameters important after the disposal closing. The study has considered the most likely scenario for evolution of the geological environment. As computing tools three codes were utilized: MELODIE, assuming a continuous 2D water flow and transfer of radionuclides from waste disposal to biosphere; TRISEC, assuming a continuous 3D water flow and NEWSAM, assuming a transient water flow in a multi-shell geometry. Results for the water circulation in different geological environment as well as the flux curves of soluble radionuclides are presented. Twenty seven radionuclides were retained as important by their radiological impact in assessing the influential EVEREST parameters. The EVEREST exercise does not prove the feasibility of a given geological disposal. It only contributes to the comprehension of the mechanisms controlling the radionuclide migration and gives a hierarchy of the questions which IPSN must answer in approaching the safety demonstrations required by ANDRA.

  19. The Fourth Geodetic Surveying Campaign on Mt. Everest and its Adjacent Area%珠峰及邻近区域第四次大地测量

    Institute of Scientific and Technical Information of China (English)

    张全德; 陈俊勇; 庞尚益; 张骥; 王泽民

    2001-01-01

    The fourth geodetic surveying campaign on Mt. Everest and itsadjacent area was successfully conducted by Chinese surveyors in 1998. Its fieldwork introductions, data acquisitions, data processing methods and the final results achieved were described in this paper. A thoroughly scientific Analyse based on comparing the 4-session geodetic surveying observations which were conducted in 1998, 1992,1975 and 1966-1968 respectively shows that Qinghai-Tibet Block is still moving on its way of northeast horizontally under the motivation caused by Indian Block movement, while relative vertical movement has waving fluctuation during the entire rising process.%叙述了我国大地测量工作者于1998年对珠穆朗玛峰及邻近区域进行的第四次大规模的大地测量外业概况和取得的成果,以及数据处理方法和最终结果。经过对1998、1966-1968、1975、1992年珠峰及邻近区域四次大地测量数据综合分析,从地学方面进行研究,得出青藏块体在印度板块的推动下,仍向北东东方向运动;珠峰地区相对垂直运动在整体抬升的过程中伴有波浪式的起伏等结论。

  20. Changes in serum potassium levels during hospitalization in patients with worsening heart failure and reduced ejection fraction (from the EVEREST trial).

    Science.gov (United States)

    Khan, Sadiya S; Campia, Umberto; Chioncel, Ovidiu; Zannad, Faiez; Rossignol, Patrick; Maggioni, Aldo P; Swedberg, Karl; Konstam, Marvin A; Senni, Michele; Nodari, Savina; Vaduganathan, Muthiah; Subacius, Haris; Butler, Javed; Gheorghiade, Mihai

    2015-03-15

    Both hyperkalemia and hypokalemia may be related to heart failure (HF) therapy and are associated with adverse outcomes. Abnormalities in serum potassium levels in hospitalized patients with HF and reduced ejection fraction (EF) have not been previously investigated. A post hoc analysis was performed in 1,907 hospitalized patients with worsening HF and reduced EF in the placebo arm of the Efficacy of Vasopressin Antagonism in HF Outcome Study with Tolvaptan (EVEREST) trial. Serum potassium was measured at randomization and at discharge or day 7. The co-primary end points were all-cause mortality (ACM) and cardiovascular mortality or the first HF hospitalization (CVM + HFH). The association between inhospital change in potassium levels and time to outcomes was evaluated using multivariate Cox regression models. Study participants had a mean age of 65.6 ± 12.0 years and were on optimal guideline-directed medical therapies, including β blockers (77%), angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (85%), and aldosterone antagonists (55%). Baseline potassium concentration was 4.3 ± 0.6 mEq/l, and hyperkalemia or hypokalemia was seen in 6.5% of the participants. On average, serum potassium level increased by 0.21 ± 0.66 mEq/l, p reduced EF hospitalized for worsening HF, serum potassium abnormalities are common at baseline (within 48 hours of admission) and potassium levels increase during hospitalization, despite aggressive diuretic therapy. However, they are not associated with all-cause or CVM or HFH. Inhospital changes in potassium may limit the implementation of evidence-based therapies such as mineralocorticoid receptor antagonists. PMID:25728846

  1. Weak precipitation, warm winters and springs impact glaciers of south slopes of Mt. Everest (central Himalaya in the last two decades (1994–2013

    Directory of Open Access Journals (Sweden)

    F. Salerno

    2014-12-01

    Full Text Available Studies on recent climate trends from the Himalayan range are limited, and even completely absent at high elevation. This contribution specifically explores the southern slopes of Mt. Everest (central Himalaya, analyzing the minimum, maximum, and mean temperature and precipitation time series reconstructed from seven stations located between 2660 and 5600m a.s.l. over the last twenty years (1994–2013. We complete this analysis with data from all the existing ground weather stations located on both sides of the mountain range (Koshi Basin over the same period. Overall we observe that the main and more significant increase in temperature is concentrated outside of the monsoon period. At higher elevations minimum temperature (0.072 ± 0.011 °C a−1, p −1, p > 0.1, while mean temperature increased by 0.044 ± 0.008 °C a−1, p −1, p p < 0.05, but the magnitude of this phenomenon is decidedly lower than the observed decrease of precipitation. (4 The lesser accumulation could be the cause behind the observed lower glacier flow velocity and the current stagnation condition of tongues, which in turn could have trigged melting processes under the debris glacier coverage, leading to the formation of numerous supraglacial and proglacial lakes that have characterized the region in the last decades. Without demonstrating the causes that could have led to the climate change pattern observed at high elevation, we conclude by listing the recent literature on hypotheses that accord with our observations.

  2. Configuration Management for eXtreme Programming

    DEFF Research Database (Denmark)

    Asklund, U.; Bendix, Lars Gotfred; Ekman, T.

    2003-01-01

    Extreme programming (XP) is a software development method that prescribes the use of 12 different practices. Four of these practices (collective code ownership, continuous integration, small releases and refactoring) can indeed be given good support by the use of simple configuration management (CM...

  3. The EU Everest project: evaluation of elements responsible for the dose equivalent associated with the final disposal in deep geological formations of radioactive waste - IPSN contributions (granite and clay formations)

    International Nuclear Information System (INIS)

    This work presents the results obtained by IPSN (Institute for Protection and Nuclear Safety), concerning the sensitivity of the radiological consequences associated with deep nuclear waste disposal for both High-Level Waste (HLW) and Medium-Level Waste (MLW), in granite and clay geological formations, considering hypothetical sites. The European project EVEREST aims to identify the main features and parameters controlling the radionuclide transfer up to human beings: flow and transport phenomena are addressed (advection, dispersion, diffusion) as well as geochemistry (glass and radionuclides solubilities, radionuclides retardation due to sorption). Engineered barriers, canister duration and pertubations induced by the repository itself have not been taken into account. Even though considering hypothetical sites, data has been taken as representative as possible of geographical real sites. 'Best estimate' parameters values and their associated range of variation have been chosen with care, in agreement with expert judgement, as well for waste packages characteristics as for hydrogeological and geochemical parameters. (author)

  4. Reconstruction of the Ice Age Glaciation in the Southern Slopes of Mt. Everest, Cho Oyu, Lhotse and Makalu (Himalaya) (Part 1)

    Institute of Scientific and Technical Information of China (English)

    Matthias Kuhle

    2006-01-01

    In the Khumbu- and Khumbakarna Himalaya an ice stream network and valley glacier system has been reconstructed for the last glacial 18 Ka BP, Stage o) with glaciogeomorphological and sedimentological methods. It was a part of the glacier system of the Himalaya and has communicated across transfluence passes with the neighbouring ice stream networks toward the W and E. The ice stream network has also received inflow from the N, from a Tibetan ice stream network, by the Kyetrak-Nangpa-Bote Koshi Drangka (Valley) in the W, by the W-Rongbuk glacier valley into the Ngozumpa Drangka (Valley), by the Central Rongbuk glacier valley into the Khumbu Drangka (Valley) and by the antecedent Arun Nadi transverse-valley in the E of the investigation area.The ice thickness of the valley glacier sections, the surface of which was situated above the snow-line,amounted to 1000~1450 m. The most extended parent valley glaciers have been measured approx. 70 km in length (Dudh Koshi glacier), 67 km (BarunArun glacier) and 80 km (Arun glacier). The tongue end of the Arun glacier has flowed down to c. 500 m and that of the Dudh Koshi glacier to c. 900 m asl. At heights of the catchment areas of 8481 (or 8475) m (Makalu), i.e., 8848 (or 8872) m (Mt. Everest,Sagarmatha, Chogolungma) this is a vertical distance of the Ice Age glaciation of c. 8000 m. The steep faces 6000~7000 m-high surfaces of the ice stream network were located 2000~5000 m above the ELA.Accordingly, their temperatures were so low, that their rock surfaces were free of flank ice and ice balconies. From the maximum past glacier extension up to the current glacier margins, 13 (altogether 14)glacier stages have been differentiated and in part 14C-dated. They were four glacier stages of the late glacial period, three of the neoglacial period and six of the historical period. By means of 130 medium-sized valley glaciers the corresponding ELA-depressions have been calculated in comparison with the current courses of the

  5. Effects of inherited cores and magmatic overgrowths on zircon (U-Th)/He ages and age-eU trends from Greater Himalayan sequence rocks, Mount Everest region, Tibet

    Science.gov (United States)

    Orme, Devon A.; Reiners, Peter W.; Hourigan, Jeremy K.; Carrapa, Barbara

    2015-09-01

    Previous constraints on the timing and rate of exhumation of the footwall of the South Tibetan detachment system (STDS) north of Mount Everest suggest rapid Miocene cooling from ˜ 700°C to 120°C between ˜14-17 Ma. However, 25 new single grain zircon He ages from leucogranites intruding Greater Himalayan Sequence rocks in the footwall of the STDS are between 9.9 and 15 Ma, with weighted mean ages between 10 and 12 Ma. Zircon grains exhibit a positive correlation between age and effective uranium (eU). Laser ablation zircon U-Pb geochronology, detailed SEM observations, and laser ablation depth-profiling of these zircons reveal low-eU 0.5-2.5 Ga inherited cores overgrown by high-eU 17-22 Ma rims. This intragranular zonation produces ages as much as 32% too young when a standard alpha-ejection correction assuming uniform eU distribution is applied. Modeling of the effects of varying rim thickness and rim eU concentration on the bulk grain eU and alpha-ejection correction suggests that zonation also exerts the primary control on the form of the age-eU correlation observed. Application of grain-specific zonation-dependent age corrections to our data yields zircon He ages between 14 and 17 Ma, in agreement with AFT and 40Ar/39Ar ages. Growth of magmatic rims followed by cooling to < 120°C within 1-6 million years supports rapid tectonic exhumation associated with slip along the STDS in the Miocene. This study highlights the importance of characterizing parent nuclide zonation in zircon He studies which seek to understand the timing of exhumation along exhumed crustal blocks.

  6. ……who has climbed a few Everests himself

    Institute of Scientific and Technical Information of China (English)

    Noel Bruce Ullrich

    2007-01-01

    @@ Mr Chancellor, Ladies and gentleman, I would like to extend my warmest congratulations to those graduating today. Today is the culmination of a number of years of hard work, sacrifice and dedication and I know how proud your own family members and colleagues will be.

  7. 78 FR 70209 - Airworthiness Directives; XtremeAir GmbH Airplanes

    Science.gov (United States)

    2013-11-25

    ..., Aerospace Engineer, FAA, Small Airplane Directorate, 901 Locust, Room 301, Kansas City, Missouri 64106; telephone: (816) 329-4123; fax: (816) 329-4090; email: karl.schletzbaum@faa.gov . SUPPLEMENTARY INFORMATION... mounts from a specific supplier may be affected. This condition, if not detected and corrected,...

  8. Organochlorine pesticides in fresh-fallen snow on East Rongbuk Glacier of Mt. Qomolangma (Everest)

    Institute of Scientific and Technical Information of China (English)

    WANG Feng; ZHU Tong; XU BaiQing; KANG ShiChang

    2007-01-01

    During a field campaign in April 2005, fresh-fallen snow samples were collected on the East Rongbuk Glacier of the Mt. Qomolangma at four altitudes (6500 m, 6300 m, 6100 m and 5900 m), to study the role of Mt. Qomolangma as "cold-traps" for Persistent Organic Pollutants. From these snow samples collected at the highest-altitude, organochlorine pesticides (OCPs):HCB,p, p'-DDT and p, p'-DDD were detected, with the concentrations in the ranges of 44-72 pg/L, 401-1560 pg/L, and 20-80 pg/L, respectively. The concentration of o, p'-DDT was around the method detection limit. Analysis of backward trajectories showed that the detected compounds came from the north of India, suggesting that DDTs detected in the snow were possibly originated from new emissions in this area. Relationships between the concentrations of OCPs in snow samples and the sampling altitudes were discussed. The altitudes had no obvious effect on HCB concentrations in the fresh-fallen snow, while increases in the concen- trations of p, p'-DDT and p, p'-DDD with increasing altitude were found, which was reversed compared to the trends observed in North America. Three factors likely resulted in this trend: (1) the properties of the target compounds; (2) the low temperatures at high altitudes; and (3) the location of the mountain sampling sites relative to their sources.

  9. Organochlorine pesticides in fresh-fallen snow on East Rongbuk Glacier of Mt.Qomolangma (Everest)

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    During a field campaign in April 2005,fresh-fallen snow samples were collected on the East Rongbuk Glacier of the Mt. Qomolangma at four altitudes (6500 m,6300 m,6100 m and 5900 m),to study the role of Mt. Qomolangma as "cold-traps" for Persistent Organic Pollutants. From these snow samples col-lected at the highest-altitude,organochlorine pesticides (OCPs):HCB,p,p′-DDT and p,p′-DDD were detected,with the concentrations in the ranges of 44―72 pg/L,401―1560 pg/L,and 20―80 pg/L,re-spectively. The concentration of o,p′-DDT was around the method detection limit. Analysis of backward trajectories showed that the detected compounds came from the north of India,suggesting that DDTs detected in the snow were possibly originated from new emissions in this area. Relationships between the concentrations of OCPs in snow samples and the sampling altitudes were discussed. The altitudes had no obvious effect on HCB concentrations in the fresh-fallen snow,while increases in the concen-trations of p,p′-DDT and p,p′-DDD with increasing altitude were found,which was reversed compared to the trends observed in North America. Three factors likely resulted in this trend: (1) the properties of the target compounds; (2) the low temperatures at high altitudes; and (3) the location of the mountain sampling sites relative to their sources.

  10. Climate change on the southern slope of Mt.Qomolangma (Everest) Region in Nepal since 1971

    Institute of Scientific and Technical Information of China (English)

    QI Wei; ZHANG Yili; GAO Jungang; YANG Xuchao; LIU Linshan; Narendra R.KHANAL

    2013-01-01

    Based on monthly mean,maximum,and minimum air temperature and monthly mean precipitation data from 10 meteorological stations on the southern slope of the Mt.Qomolangma region in Nepal between 1971 and 2009,the spatial and temporal characteristics of climatic change in this region were analyzed using climatic linear trend,Sen's Slope Estimates and Mann-Kendall Test analysis methods.This paper focuses only on the southern slope and attempts to compare the results with those from the northern slope to clarify the characteristics and trends of climatic change in the Mt.Qomolangma region.The results showed that:(1) between 1971 and 2009,the annual mean temperature in the study area was 20.0℃,the rising rate of annual mean temperature was 0.25℃/10a,and the temperature increases were highly influenced by the maximum temperature in this region.On the other hand,the temperature increases on the northern slope of Mt.Qomolangma region were highly influenced by the minimum temperature.In 1974 and 1992,the temperature rose noticeably in February and September in the southern region when the increment passed 0.9℃.(2) Precipitation had an asymmetric distribution; between 1971 and 2009,the annual precipitation was 1729.01 mm.In this region,precipitation showed an increasing trend of 4.27mm/a,but this was not statistically significant.In addition,the increase in rainfall was mainly concentrated in the period from April to October,including the entire monsoon period (from June to September) when precipitation accounts for about 78.9% of the annual total.(3) The influence of altitude on climate warming was not clear in the southern region,whereas the trend of climate warming was obvious on the northern slope of Mt.Qomolangma.The annual mean precipitation in the southern region was much higher than that of the northern slope of the Mt.Qomolangma region.This shows the barrier effect of the Himalayas as a whole and Mt.Qomolangma in particular.

  11. Calculating the Potato Radius of Asteroids using the Height of Mt. Everest

    CERN Document Server

    Caplan, M E

    2015-01-01

    At approximate radii of 200-300 km, asteroids transition from oblong `potato' shapes to spheres. This limit is known as the Potato Radius, and has been proposed as a classification for separating asteroids from dwarf planets. The Potato Radius can be calculated from first principles based on the elastic properties and gravity of the asteroid. Similarly, the tallest mountain that a planet can support is also known to be based on the elastic properties and gravity. In this work, a simple novel method of calculating the Potato Radius is presented using what is known about the maximum height of mountains and Newtonian gravity for a spherical body. This method does not assume any knowledge beyond high school level mechanics, and may be appropriate for students interested in applications of physics to astronomy.

  12. Research and Evaluation on Ecotourism Resources of Jilong Valley in Everest National Nature Reserve

    Institute of Scientific and Technical Information of China (English)

    WangDegang; LiQian

    2005-01-01

    Jitong is a place behind The Himalayas, which is almost isolated from the world. There is typical vertical ecosystem thanks to its special geological environment. So it is honored as ""the most abundant species gene warehouse in the Plateau Area""and ""the most beautiful valley in the world"". To exploit this valiey is necessary along with the construction of Jilong Port on the border of Sino-Nepal Based on the research on the spot, the ecological resources there are evaluated and an idea that regards hiking tourism as main form and ecotourism as the theme is put forward in this paper, which explores a way to develop the valley on the basis of sustainability.

  13. Open access high throughput drug discovery in the public domain: a Mount Everest in the making.

    Science.gov (United States)

    Roy, Anuradha; McDonald, Peter R; Sittampalam, Sitta; Chaguturu, Rathnam

    2010-11-01

    High throughput screening (HTS) facilitates screening large numbers of compounds against a biochemical target of interest using validated biological or biophysical assays. In recent years, a significant number of drugs in clinical trails originated from HTS campaigns, validating HTS as a bona fide mechanism for hit finding. In the current drug discovery landscape, the pharmaceutical industry is embracing open innovation strategies with academia to maximize their research capabilities and to feed their drug discovery pipeline. The goals of academic research have therefore expanded from target identification and validation to probe discovery, chemical genomics, and compound library screening. This trend is reflected in the emergence of HTS centers in the public domain over the past decade, ranging in size from modestly equipped academic screening centers to well endowed Molecular Libraries Probe Centers Network (MLPCN) centers funded by the NIH Roadmap initiative. These centers facilitate a comprehensive approach to probe discovery in academia and utilize both classical and cutting-edge assay technologies for executing primary and secondary screening campaigns. The various facets of academic HTS centers as well as their implications on technology transfer and drug discovery are discussed, and a roadmap for successful drug discovery in the public domain is presented. New lead discovery against therapeutic targets, especially those involving the rare and neglected diseases, is indeed a Mount Everestonian size task, and requires diligent implementation of pharmaceutical industry's best practices for a successful outcome.

  14. EPISODE: A N E XTREME P ROGRAMMING M ETHOD F OR I NNOVATIVE S OFTWARE B ASED O N S YSTEMS D ESIGN A ND I TS P RACTICAL S TUDY

    Directory of Open Access Journals (Sweden)

    Takaaki Goto

    2014-07-01

    Full Text Available In software development, the waterfall model is com monly used, especially for large-scale software systems. For smaller-scale software development, ag ile software development approaches such as extreme programming or scrum are used. Traditional software development methodologies are mainly targeted toward customer-centric development, and therefore, new software methodologies are often not well received in the industry. In this study, we propose a new software development methodology that is aim ed at developing innovative software using artificial intelligence (AI, idea creation, value engineering , and systems design. The name of our method is named as EPISODE (Extreme Programming method for Innovative SOftware based on systems DEsign. EPISO DE supports the efficient and creative development of open source software (OSS by small groups. More over we describe an evaluation of EPISODE in a class

  15. The Analysis of Harold White applied to the Natario Warp Drive Spacetime. From $10$ times the mass of the Universe to the mass of the Mount Everest

    OpenAIRE

    Loup, Fernando

    2012-01-01

    Warp Drives are solutions of the Einstein Field Equations that allows superluminal travel within the framework of General Relativity. There are at the present moment two known solutions: The Alcubierre warp drive discovered in $1994$ and the Natario warp drive discovered in $2001$. However as stated by both Alcubierre and Natario themselves the warp drive violates all the known energy conditions because the stress energy momentum tensor is negative implying in a negative energy density. While...

  16. Reconstruction of the Ice Age Glaciation in the Southern Slopes of Mt. Everest, Cho Oyu, Lhotse and Makalu (Himalaya) (Part 2)

    Institute of Scientific and Technical Information of China (English)

    Matthias Kuhle

    2006-01-01

    @@ Editorial Note: The first section of this article was published in June 2006 (cf. pages 91~124 in No. 2, Vol. 3),and the publishing here is its sequel, which includes 22 Figures (i.e. Figures 9~30), two photos (Photo 1 and 2)and one table (i.e. Table 7). The figures before No.9 mentioned in the text of this part were published in previous issue, and please refer to them while reading. We sincerely apologize to you for any inconvenience this arrangement may have caused you.

  17. Family matters: football playing daughters, gender and bonding

    OpenAIRE

    Pielichaty, Hanya

    2014-01-01

    Since the 1990s, scholarly work surrounding women’s football has focused on sexualities (Caudwell, 1999), gender identity development (Jeanes, 2006; 2011), international perspectives (Ben-Porat, 2011) and sexualisation through the media (Jones and Greer, 2011). Up until now the relationships between footballer and family have yet to be explored and analysed. Furthermore, research on youth studies has overlooked the importance of family relationships to young people over the past two decades (...

  18. Understanding Tools and Practices for Distributed Pair Programming

    NARCIS (Netherlands)

    Schümmer, T.; Lukosch, S.G.

    2009-01-01

    When considering the principles for eXtreme Programming, distributed eXtreme Programming, especially distributed pair programming, is a paradox predetermined to failure. However, global software development as well as the outsourcing of software development are integral parts of software projects. H

  19. Orange County Littoral Cell CRSMP Wastewater and Power Plant Discharge Structures

    Data.gov (United States)

    California Department of Resources — Graphical depiction of wastewater and power plant discharge pipelines/outlets locations in Southern California.The shapefile was collected by Everest International...

  20. 前沿消息

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    Jeep Xtreme Performance亮相北京车展 顶级户外产品莅临Jeep吉普,共同打造户外天地 (2014年4月21日.北京)继中国首家户外专营店Jeep Xtrertie Pedortnace正式亮相京城后,Jeep Xtreme Performace携手旗下明星产品亮相北京车展。

  1. Earth sciences within the project Ev-K2-CNR: Geodesy and geophysics; Le scienze della Terra nel progetto Ev-K2-CNR: Geodesia e geofisica

    Energy Technology Data Exchange (ETDEWEB)

    Poretti, Giorgio [Trieste, Univ. (Italy). Dipt. di Scienze Matematiche

    1997-05-01

    Earth Sciences started the Ev-K2-CNR project in 1987 with the comparison between the heights of Mt. Everest and K2. Several gravimetric campaigns followed in the most difficult areas of the Himalayas. In 1991 a GPS network was established in Nepal for the determination of the Earth crust movements in the area. In 1992 a precise measurement of mount Everest was performed with classical and satellite technologies. Mount K2 was remeasured in Summer 1996.

  2. 珠穆朗玛峰国家自然保护区吉隆藏布峡谷生态资源考察与评价%Research and Evaluation on Ecotourism Resources of Jilong Valley in Everest National Nature Reserve

    Institute of Scientific and Technical Information of China (English)

    王德刚; 李倩

    2005-01-01

    Jilong is a place behind The Himalayas, which is almost isolated from the world. There is typical vertical ecosystem thanks to its special geological environment. So it is honored as "the most abundant species gene warehouse in the Plateau Area"and "the most beautiful valley in the world To exploit this valley is necessary along with the construction of Jilong Port on the border of Sino-Nepal.Based on the research on the spot, the ecological resources there are evaluated and an idea that regards hiking tourism as main form and ecotourism as the theme is put forward in this paper, which explores a way to develop the valley on the basis of sustainability.

  3. Single-order lamellar multilayer gratings

    NARCIS (Netherlands)

    Meer, van der R.

    2013-01-01

    A major challenge in the soft x-ray (SXR) and eXtreme UltraViolet (XUV) spectral ranges is the ability to manipulate the incident radiation using optical elements. By patterning conventional multilayer mirrors with nanoscale structures, novel optical elements with a variety of optical properties can

  4. Developer Stories: Improving Architecture in Agile Practice

    DEFF Research Database (Denmark)

    Tjørnehøj, Gitte; Jensen, Rolf Njor; Platz, Niels

    2007-01-01

    Within the field of Software Engineering emergence of agile methods has been a hot topic since the late 90s. eXtreme Programming (XP) ([1]) was one of the first agile methods and is one of the most well-known. However research has pointed to weaknesses in XP regarding supporting development...

  5. Visualizing Testsuites to Aid in Software Understanding

    NARCIS (Netherlands)

    Cornelissen, B.; Van Deursen, A.; Moonen, L.; Zaidman, A.

    2006-01-01

    Agile software development methods such as eXtreme Programming have brought renewed attention to testing during the software development process, both as a quality assurance method and as a form of live documentation. It is for this reason that a software system’s testsuite is an ideal starting poin

  6. A Novel Approach for Collaborative Pair Programming

    Science.gov (United States)

    Goel, Sanjay; Kathuria, Vanshi

    2010-01-01

    The majority of an engineer's time in the software industry is spent working with other programmers. Agile methods of software development like eXtreme Programming strongly rely upon practices like daily meetings and pair programming. Hence, the need to learn the skill of working collaboratively is of primary importance for software developers.…

  7. Does SW Monsoon Influence Total Suspended Matter Flux into the Arabian Sea?

    Digital Repository Service at National Institute of Oceanography (India)

    Raghavan, B.R.; Chauhan, O.S.

    area therefore has a alongshore hydrography round the year. METHODOLOGY In order to resolve the influence of the SWM, midtide-synchronous field measurements were carried out between 13.30 – 15.150N; 73.30 – 74.300E) at predetermined 24 stations... was applied to remove image distortion and to bring a standard geographic projection, with modified everest datum (i.e., a local geodetic datum, based on the everest spheroid that best fits the extent of the Indian subcontinent). Subsequently, co...

  8. Field evaluation of commercial repellents against the floodwater mosquito Psorophora columbiae (Diptera: Culicidae) in St. Johns County, Florida.

    Science.gov (United States)

    Qualls, Whitney A; Xue, Rui-De; Holt, J Adam; Smith, Mike L; Moeller, Jeanne J

    2011-11-01

    Three plant-based repellents-REPEL LEMON Eucalyptus Insect Repellent Lotion (active ingredient [AI] 30% oil of eucalyptus), Bite Blocker Xtreme Sportsman Organic Insect Repellent ([AI] 3% soybean oil, 6% geranium oil, and 8% castor oil), and Bite Blocker BioUD Insect Repellent ([AI] 7.75% 2-undecanone)--were evaluated against OFF! ([AI] 15% N,N-diethyl-m-toluamide or N,N-diethyl-3-methyl-benzamide, also called DEET) at a field site in Elkton, FL, to determine the mean protection time provided against Psorophora columbiae (Dyar & Knab). These products provided different protection times against biting Ps. columbiae. REPEL provided the longest protection time (330 min) followed by Bite Blocker Xtreme Sportsman (163 min), Bite Blocker BioUD (140 min), and OFF! (130 min). This study provides the first information about plant-based insect repellent protection times against Ps. columbiae. PMID:22238886

  9. 才下少林 又上西藏

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    Towering at an incredible 8, 850 meters, Everest has been quite the jaw-dropper for anyone who has ever had any admiration for any wonder of the world. Since the first ascent to the top in 1953, more than 550 climbers from some 20 countries have accomplished the summit.

  10. 77 FR 26739 - High Pressure Steel Cylinders From the People's Republic of China: Final Determination of Sales...

    Science.gov (United States)

    2012-05-07

    ... financial ratios from Everest Kanto Cylinder Ltd. to Thai Metal Drum Manufacturing Public Company Limited.... Selection of Surrogate Financial Ratios B. Truck Freight C. Labor Comment III: Double Remedy Comment IV... of China: Preliminary Determination of Sales at Less than Fair Value, 76 FR 77964 (December 15,...

  11. Hi-tech Flame

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Modern science plays a crucial role in lighting the Olympic flame on the world’s highest mountain when the world saw live telecasts of the Olympic flame burning onthe top of Mount Qomolangma(Mount Everest) at 9:17 on the morning of May 8, few realized the years of work and high level of technology that had

  12. 珠峰,我们来啦!

    Institute of Scientific and Technical Information of China (English)

    李太行

    2002-01-01

    One morning in July 2001, a groupof colorful caravans gatheredin front of the Tibet Mansion,Beijing, waiting for the start of a tour toTibet. This was the starting point of theFlowing Rainbow: Beijing-Tibet MountEverest Environmental Protection ArtTour.

  13. Energy and matter

    OpenAIRE

    Gobato, Ricardo; Gobato, Alekssander; Fedrigo, Desire Francine Gobato

    2015-01-01

    Our work is an approach between matter and energy. Using the famous equation E = mc^2, Einstein and the Law of Universal Gravitation of Newton, we estimate that a small amount matter converted into energy is needed to lift, using the gravitational potential energy equation on the surface, a mountain of solid iron or even Mount Everest.

  14. A primitive cladid crinoid from the Jiacun Group, Tibet (Darriwilian, Middle Ordovician)

    DEFF Research Database (Denmark)

    Donovan, Stephen K.; Harper, David A.T.; Renbin, Zhan;

    2012-01-01

    Biozone; coeval rocks of similar lithology outcrop at the summit of Everest. A new crinoid morphospecies, Segmentocolumnus (col.) hanshessi, is tentatively considered a ‘stem-group cladid’, perhaps a dendrocrinid. The proxistele is broad and pentagonal in section with a broad, pentagonal axial canal...

  15. Understanding Turnover Intentions and Behavior of Indian Information Systems Professionals: A Study of Organizational Justice, Job Satisfaction and Social Norms

    Science.gov (United States)

    Iyer, Vidya V.

    2011-01-01

    Despite the phenomenal growth projected for the Indian information technology (IT) industry, one of the biggest challenges it faces is the high rate of turnover in offshore supplier firms based in India (Everest Research Group 2011). According to recent estimates, turnover rates among Indian information systems (IS) professionals have been…

  16. The Effects of Pair Programming on Learning Efficiency in Short Programming Assignments

    OpenAIRE

    Subbaraya KUPPUSWAMI; Kalimuthu VIVEKANANDAN

    2004-01-01

    Pair programming is one of the important practices of a lightweight development methodology namely eXtreme Programming (XP). It emphasizes the practice of two persons working together at a single computer terminal, to design, code and test computer programs. The effects of pair programming on software development in industrial organizations were studied and it was found that pair programming increases the productivity by 15%. This evidence created an interest in amongst community of computer ...

  17. 千兆路由的安全

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    D-Link获得Wi-Fi联盟颁发的draft802.11n认证,首批通过认证的产品包括D-Link Xtreme N路由器(DIR-655)和PCMICA无线网卡(DWA-652)。在互操作性、安全性和向下兼容性上都有保障。

  18. Problematika výběru agilní metodiky vývoje software

    OpenAIRE

    Fujdiar, Robert

    2013-01-01

    Theme of this thesis is how to choose between agile methodologies of software development. Several agile methodologies, such as SCRUM, Kanban and eXtreme programming are described and also methods of choosing between methodologies or management techniques are discussed. New method of multi-criteria decision process on how to choose between Agile methodologies based on multi-dimensionality is presented with option of improving agile experience by adopting additional techniques. Diploma thesis ...

  19. Support For Distributed Programming In Extreme Style

    Directory of Open Access Journals (Sweden)

    Jacek Dajda

    2005-01-01

    Full Text Available The basic limitation emerging from practising eXtreme Programming methodology is theconstraint of close physical proximity between the members of the collaborating team including customer. This became the main idea behind research on XP supporting environmentfor geographically distributed teams. This work presents basic assumptions, elaborated architecture and selected implementation issues for the system of this type. Deliberations aresupplied with the initial results of the verification of its usability based on the users tests.

  20. An Investigation of Team Effectiveness in Agile Software Development

    OpenAIRE

    Haraldsen, Lars Martin Riiser

    2012-01-01

    Abstract Agile teamwork has been widely used and accepted in today's industry of software development. The methods in agile teamwork claim to improve performance and predictability, and has during the past years become the target for an emerging area of research. The majority of the existing studies concerning agile teamwork mainly focus around eXtreme Programming (XP). Abstract This report is one of few that discuss teamwork in software development having the agile methodology “Scr...

  1. Integrating agile software development into stage-gate managed product development

    OpenAIRE

    Karlström, Daniel; Runeson, Per

    2006-01-01

    Agile methods have evolved as a bottom-up approach to software development. However, as the software in embedded products is only one part of development projects, agile methods must coexist with project management models typically of the stage-gate type. This paper presents a qualitative case study of two large independent software system projects that have used eXtreme Programming (XP) for software development within contexts of stage-gate project management models. The study is comprised o...

  2. Thomas讲网球鞋之

    Institute of Scientific and Technical Information of China (English)

    Thomas Eichmann; Sexxxxxy(译)

    2010-01-01

    Hi大家好,我是Thomas Eichmann,这次为大家带来的可是去年除NIKE、ADIDAS以外最热门的两双网球鞋,它们是索德林穿着的LOTTO SYN-RAPTOR XTREME SPEED与库兹涅佐娃、克里斯特尔斯的FILA TORNEOⅡ.

  3. The Effect of Men's Body Attitudes and Motivation for Gym Attendance.

    Science.gov (United States)

    Caudwell, Kim M; Keatley, David A

    2016-09-01

    Caudwell, KM and Keatley, DA. The effect of men's body attitudes and motivation for gym attendance. J Strength Cond Res 30(9): 2550-2556, 2016-The current study integrates men's body attitudes with implicitly and explicitly measured motivation to investigate the role of these factors in predicting gym attendance. Male participants (N = 99) who regularly attended a gym were recruited to participate in an online questionnaire. Participants completed implicit and explicit measures of motivation, explicitly measured men's body attitudes, and reported the average number of gym visits per week. Attitudes related to body fat and explicitly measured autonomous motivation significantly predicted typical gym attendance. Implicitly measured motivation significantly and negatively predicted gym attendance. Results indicate some support for a dual-systems account of gym attendance. Men's body attitudes and autonomous motivation influences gym attendance; however, implicitly measured motivation showed antagonistic effects. Although individuals may explicitly state their autonomous motivation for gym attendance, attendance may also be influenced at the explicit level. Health and fitness professionals may improve gym attendance by focusing on people's reasons for attending a gym, facilitating autonomous motivation in clients, and minimizing the influence of controlled reasons for exercise.

  4. New Concepts in Digital Reference

    CERN Document Server

    Lankes, R David

    2009-01-01

    Let us start with a simple scenario: a man asks a woman 'how high is Mount Everest?' The woman replies '29,029 feet'. Nothing could be simpler. Now let us suppose that rather than standing in a room, or sitting on a bus, the man is at his desk and the woman is 300 miles away with the conversation taking place using e-mail. Still simple? Certainly - it happens every day. So why all the bother about digital (virtual, electronic, chat, etc.) reference? If the man is a pilot flying over Mount Everest, the answer matters. If you are a lawyer going to court, the identity of the woman is very importa

  5. The Jordan Romero Case; A Biological Super Athlete or a Product of the Sport Industry

    Directory of Open Access Journals (Sweden)

    George Kipreos

    2012-08-01

    Full Text Available Many questions have arisen in regards to Jordan Romero’s climbing actions, in terms of ethics and legality. Although, he has already successfully climbed most of the highest summits, his last expedition to climb mountain Everest, has found strong opposition and criticism. Jordan’s decision to climb Everest, at the age of 13, comes into contradiction with the convention on Human Rights, the International Public Law, the climbing rules and regulations of Nepal, and the Law of U.S.A. What should also be put into reference is the fact that Romero’s pursuit violates the Article No. 1 in the Declaration of Tyrol 2002 (Mountaineering, which defines individual responsibility for the activities of the climber. This paper outlines the legal and ethical aspects of Jordan’s venture, taking into account the biological hazards.

  6. 免费工具

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Kaspersky Anti-Virus6.0.1.360 Beta;天网防火墙个人版Athena 20063.0.0.1001;AntiVir Personal Edition 7;Daemon Tools 4.0.3;EVEREST 3.01.679 Beta;NJStar Communicator(南极星全球通)2.60……

  7. Corporate Social Necessity

    Institute of Scientific and Technical Information of China (English)

    ZHANG HONG

    2008-01-01

    @@ Up until recently,Wang Shi was one of China's most respected role models and businessman.Wang,chairman of Vanke (万科),China's biggest property developer,has appeared in commercials for Ping An Insurance and Motorola,has scaled Mount Everest,and is often referred to as the godfather of China's real estate business.His blog is one of the most popular in China.But last month,Wang's blog got him in trouble.

  8. Sintering behavior and mechanical properties of zirconia compacts fabricated by uniaxial press forming

    OpenAIRE

    Oh, Gye-Jeong; Yun, Kwi-Dug; Lee, Kwang-Min; Lim, Hyun-Pil; Park, Sang-Won

    2010-01-01

    PURPOSE The purpose of this study was to compare the linear sintering behavior of presintered zirconia blocks of various densities. The mechanical properties of the resulting sintered zirconia blocks were then analyzed. MATERIALS AND METHODS Three experimental groups of dental zirconia blocks, with a different presintering density each, were designed in the present study. Kavo Everest® ZS blanks (Kavo, Biberach, Germany) were used as a control group. The experimental group blocks were fabrica...

  9. Journey through Nepal

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Nepal is one of the richest countries in the world in terms of bio-diversity due to its unique geographical position and altitude variation. The elevation of the country ranges from 60 meters above sea level to the highest point on earth, Mt. Everest at8,848 meters, all within a distance of 150 kilometers resulting in climatic conditions from Sub-tropical to Arctic.

  10. VEGETATION CHANGE IN THE MT.QOMOLANGMA NATURAL RESERVE FROM 1981 TO 2001

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    1 Introduction On 18 May 1989,the Mt.Qomolangma (Everest)Natural Reserve(abbr.MQNR)in Tibet Autonomous Region formally came into existence and it was listed as World Network of Biosphere Reserves(WNBR)in May 2005.The MQNR is a comprehensive reserve,which mainly protects alpine ecosystems,plateau natural landscapes,geological remains and Tibetan historical and cultural heritages.

  11. Esiplaanil heli / Harri Slip

    Index Scriptorium Estoniae

    Slip, Harri

    2015-01-01

    Kõrvaklapid hinnaga alla 200 €: AKG Y50BT, Audio-Technica, Beyerdynamic Custom Street, Bose SoundTrue around-ear II, Creative Aurvana Gold, Denon AH-MM200, Focal Spirit One S, Grado SR 80e, JBL Everest V300, Klipsch Reference On Ear, Panasonic RP-HD10, Philips SHB8850NC, Sennheiser HD 25, SMS Audio On-Ear Wired Sport, Sony MDR-100AAP

  12. Clinical trial experience with the MitraClip catheter based mitral valve repair system.

    Science.gov (United States)

    Maisano, Francesco; Godino, Cosmo; Giacomini, Andrea; Denti, Paolo; Arendar, Iryna; Buzzatti, Nicola; Canna, Giovanni La; Alfieri, Ottavio; Colombo, Antonio

    2011-12-01

    Severe mitral regurgitation (MR) confers a poor prognosis, in particular for patients with heart failure. Based on the results of the Euro Heart Survey, a large proportion of patients with mitral regurgitation is not referred to surgery and many other patients are rejected for cardiac surgery due to the high surgical risk or co-pathologies. Improving ventricular function with ACE inhibitors, beta-blockers and CRT may reduce mitral regurgitation, but for most patients a mechanical intervention is ultimately preferable. Mitral valve surgery is invasive and requires a long recovery period; therefore, less invasive and effective approaches are highly desirable, particularly in high risk patients. Therefore, new techniques have been recently developed to treat MR with percutaneous approach. The MitraClip device (Abbott Vascular, Menlo Park, CA) is used to treat both functional and degenerative mitral valve regurgitation. Its safety and efficacy has been initially tested in the Endovascular Valve Edge-to-Edge REpair Study (EVEREST), while MitraClip has been compared to surgery in the EVEREST II randomized trial. Besides EVEREST trials, safety and efficacy of the device as well as its health economic value is under evaluation in ongoing registries. Although the field of catheter based management of MR is at an early stage, initial clinical results have demonstrated that catheter based approaches can reduce MR, suggesting there is a great deal of potential for clinical benefit to patients with MR.

  13. 一种基于.NET的数据转换方法--从AutoCAD数据到Map Info%A Method of NET-based Data Conversion from AutoCAD to MapInfo

    Institute of Scientific and Technical Information of China (English)

    魏峰远; 郭继发

    2006-01-01

    分析了Maplnfo和AutoCAD的DXF、DWG文件格式,论述了传统AutoCAD数据到 Maplnfo转换的方法,提出了AutoCAD数据向Maplnfo转换的原则,并提出利用MapXtreme 2004和AutoCAD ActiveX实现DWG文件向Maplnfo文件转换的方法.分析了实现的基础理论,论述了实现过程和数据丢失的补救方法.

  14. 极限编程(XP)在工程质量监管系统中的应用%Applying Extreme Programming for Information Systems of Engineering Quality Monitoring and Controlling

    Institute of Scientific and Technical Information of China (English)

    夏静清

    2006-01-01

    "极限编程"(eXtreme Programming,简称XP)是目前最流行的敏捷软件开发方法(Agile Software Development,ASD).通过XP在实际项目中的应用"实践",本文将对XP的理论和实践方法进行探讨,并衡量XP方法在项目中的应用效果,给出实际应用XP方法的一些建议.

  15. Mobile systems development

    DEFF Research Database (Denmark)

    Pedersen, Ole; Kristiansen, Martin Lund; Kammersgaard, Marc N.;

    2007-01-01

    development teams in the mobile software industry. By taking a process view on development of mobile systems we seek to explore the strengths and limitations of eXtreme Programming (XP) in the context of mobile software development. Following an experimental approach a mobile systems development project...... components whenever possible. Test regularly oil real devices, since the difference between emulators and real devices are significant. Take advantage of spikes. Do not use pair programming when spiking, and remember to write unit tests for production code that was initially created during spikes. Monitor...

  16. Continuous Integration, essential piece in the software development.

    Directory of Open Access Journals (Sweden)

    Eduardo Aranda

    2012-12-01

    Full Text Available Continuous Integration is a practice proposed by eXtreme Programming, one of the most popular agile methodologies, which implementation involves automating one of the most heavy and complex task to predict the process of integration in software development. In this work it is described general aspects related to the practice of Continuous Integration in software development, so it is presented the feasibility of its application due the benefits it provides and the risks that can be mitigated with the use of it. It constitutes a theoretical basis for understanding and showing that this practice is an essential piece for software development.

  17. From agile to lean: the perspectives of the two agile online communities of interest

    OpenAIRE

    Wang, Xiaofeng; Lane, Michael; Conboy, Kieran

    2011-01-01

    peer-reviewed In the last several years there has been a noticeable focus shift of agile methods from eXtreme Programming (XP) and Scrum to Lean approaches, which is indicated as ???from agile to lean???. However our understanding of the driving factors behind this focus shift is very limited. The study proposed in this paper attempts to investigate the shift through a content analysis of two major agile mailing lists. The expected result is a set of driving factors behind the shift from a...

  18. FPGA Implementation of a Frame Synchronization Algorithm for Powerline Communications

    Directory of Open Access Journals (Sweden)

    S. Tsakiris

    2009-09-01

    Full Text Available This paper presents an FPGA implementation of a pilot–based time synchronization scheme employing orthogonal frequency division multiplexing for powerline communication channels. The functionality of the algorithm is analyzed and tested over a real powerline residential network. For this purpose, an appropriate transmitter circuit, implemented by an FPGA, and suitable coupling circuits are constructed. The system has been developed using VHDL language on Nallatech XtremeDSP development kits. The communication system operates in the baseband up to 30 MHz. Measurements of the algorithm's good performance in terms of the number of detected frames and timing offset error are taken and compared to simulations of existing algorithms.

  19. Aprimorando a Gerência e o Desenvolvimento de Software com Metodologias Ágeis

    OpenAIRE

    Mauricio Andreazza Sganderla; Guilherme Lacerda; Vinicius Gadis Ribeiro; Sidnei Renato Silveira

    2016-01-01

    Este artigo aborda a melhoria da gerência e construção de software utilizando as metodologias ágeis eXtreme Programming e Scrum. São aplicadas as melhores práticas de ambas as metodologias em uma equipe de desenvolvimento de software, em um ambiente em que não havia nenhum processo bem definido de desenvolvimento de software. A escolha pelo uso das metodologias ágeis foi definida, pois atende ao dinamismo do cenário atual, requisitos voláteis, ambiente mais colaborativo e menos burocrático, t...

  20. ABB推出针对极端应用环境的AC500XC系列PLC

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    近日,ABB集团在华推出AC500-XC系列可编程控制器(PLC)产品。XC代表eXtreme Conditions(极端条件应用)。XC系列PLC让极端环境下的控制变得更轻松、更明显,也更简单直观,可以让用户有效节省在工程设计和操作中费用。

  1. 基于EclipseRCP的隧道通风安全信息系统研究%Study on Tunnel Ventilation Safety Information System Based on Eclipse RCP

    Institute of Scientific and Technical Information of China (English)

    李少利

    2011-01-01

    运用Eclipse RCP技术、集成WindowBuilder、Hibernate3.2、JFreechart、PO12.5等多种开发工具,以MapXtremeJava4.8为地图服务器,选用Oracle10g数据库,设计并开发了隧道施工通风安全信息系统,具有日常管理、电子地图、数据分析、声光报警、短信提醒等特点,实现了隧道施工通风安全信息的可视化管理。%A tunnel ventilation safety information system, is developed by adopting Eclipse RCP technology and integrating Window Builder, Hibernate 3.2, JFreechart and POI 2.5, etc. , with MapXtreme Java 4.8 as map server and Oracle 10g as data-base. The developed system has many advantages, including daily management, electronic map, data analyzing, acoustic and visual alarming. In this way, visualized management of tunnel ventilation safety information is realized.

  2. Marginal fit of anterior 3-unit fixed partial zirconia restorations using different CAD/CAM systems

    Science.gov (United States)

    Song, Tae-Jin; Kwon, Taek-Ka; Han, Jung-Suk; Lee, Jai-Bong; Kim, Sung-Hun

    2013-01-01

    PURPOSE Few studies have investigated the marginal accuracy of 3-unit zirconia fixed partial dentures (FPDs) fabricated by computer-aided design/computer-aided manufacturing (CAD/CAM) system. The purpose of this study was to compare the marginal fit of zirconia FPDs made using two CAD/CAM systems with that of metal-ceramic FPDs. MATERIALS AND METHODS Artificial resin maxillary central and lateral incisors were prepared for 3-unit FPDs and fixed in yellow stone. This model was duplicated to epoxy resin die. On the resin die, 15 three-unit FPDs were fabricated per group (45 in total): Group A, zirconia 3-unit FPDs made with the Everest system; Group B, zirconia 3-unit FPDs made with the Lava system; and Group C, metal-ceramic 3-unit FPDs. They were cemented to resin dies with resin cement. After removal of pontic, each retainer was separated and observed under a microscope (Presize 440C). Marginal gaps of experimental groups were analyzed using one-way ANOVA and Duncan test. RESULTS Mean marginal gaps of 3-unit FPDs were 60.46 µm for the Everest group, 78.71 µm for the Lava group, and 81.32 µm for the metal-ceramic group. The Everest group demonstrated significantly smaller marginal gap than the Lava and the metal-ceramic groups (P.05). CONCLUSION The marginal gaps of anterior 3-unit zirconia FPD differed according to CAD/CAM systems, but still fell within clinically acceptable ranges compared with conventional metal-ceramic restoration. PMID:24049561

  3. Spinning Giant in Anyang asks for Strategic Investment in Reconsolidation

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ According to a recent public announcement issude by Anyang municipal government,its largest cotton textile company,also the Everest in cotton spinning sector in Henan province,is now on the brink of bankruptcy oving to drooped business from global economic recessionl. Changtai Textile Group,having 400,000spindles in spinning capacity and 540,000square meters of plant area,three industrial parks,eight subsidiary companies,two ginners,was once the city honor for its giorious past,an undeniable contribution to local 5600 jobs,adorable taxpayer ,and one of the top 50 in the national cotton textile industry.

  4. Thin Places

    OpenAIRE

    Lockwood, Sandra Elizabeth

    2013-01-01

    This inquiry into the three great quests of the twentieth century–the South Pole, Mount Everest, and the Moon–examines our motivations to venture into these sublime, yet life-taking places. The Thin Place was once the destination of the religious pilgrim seeking transcendence in an extreme environment. In our age, the Thin Place quest has morphed into a challenge to evolve beyond the confines of our own physiology; through human ingenuity and invention, we reach places not meant to accommod...

  5. FARKLI SİSTEM VE MATERYALLERLE ÜRETİLEN ZİRKONYA ALT YAPILARIN KENAR UYUMLARININ KARŞILAŞTIRILMASI Comparison of Marginal Fit of Zirconia Copings Produced by Different Systems and Materials

    OpenAIRE

    Gültekin, Pınar; Deniz ŞEN; Aydın, Murat

    2013-01-01

    Purpose: The aim of this study was to compare marginal fit of zirconia copings produced by different systems and materials.Material and Methods: Tooth preparation with circumferential shoulder was performed on maxillary premolar acrylic tooth model. Copings (n=10) were produced with 5 different system-zirconia blocks (Cerec-InCoris ZI, Everest-BioZH, Celay-In-Ceram Zirconia, Zirkonzahn-IceZirkon ve Lava-Frame Zirconia) on prepared tooth model. Metal copings (Ni-Cr) were used as a control grou...

  6. Co-operation on The Roof of the World

    Institute of Scientific and Technical Information of China (English)

    Maria; AntoniaStroni

    1996-01-01

    A freezing wind sweeps through the narrow Tibetan valley,whistling over the sand,stones and dry grass,buffeting the grazing sheep and the low houses of the tiny village which nestles there at an altitude of 4,600 meters.High overhead white clouds scud across skies of an unimaginably intense cobalt blue.Towards the south,the glistening peak of Everest rises momentarily from amidst the bank of clouds which hover over the barren ochre slopes already in autumnal garb and heralding the onset of winter.The farmers have been busy gathering the

  7. Tracing the sources of particles in the East Rongbuk ice core from Mt. Qomolangma

    Institute of Scientific and Technical Information of China (English)

    XU JianZhong; HOU ShuGui; CHEN FuKun; REN JiaWen; QIN DaHe

    2009-01-01

    Sr-Nd-Pb isotopic tracer was applied, for the first time, to identifying the sources of the particles in the East Rongbuk ice core from Mt. Qomalangma (Everest). The results show that the particles in the dirty layers originate mainly from local sources, while the particles in the non-dirty layers are consistent with the features of dust from the arid regions in northwestern India. The HYSPLIT model shows that the air trajectory goes first through northwestern India before reaching the drilling site of ice core when dust storms occur in northwestern India, confirming northwestern India as a possible source of dust in the East Rongbuk ice core.

  8. Writing Travel in the Anthropocene: Disastrous Life at the End of the Arctic

    DEFF Research Database (Denmark)

    Graulund, Rune

    2016-01-01

    could have imagined just a century ago. Globalisation and increased mobility, whether it is that of the privileged few who can travel on holiday on jet airplanes, or that of the immigrant labourer seeking employment by crossing borders on foot, have meant millions (if not indeed billions) are constantly...... by a rapid increase in the mobility of people, goods and information, but primarily examine the impact of the Anthropocene on the notion of travel. For in a world in which the peak of Mount Everest is littered with toilet paper and the Great Pacific Garbage Patch is potentially twice the size of the US...

  9. En bloc resection of a thoracic chordoma is possible using minimally invasive anterior access: An 8-year follow-up

    Directory of Open Access Journals (Sweden)

    Anand Goomany

    2016-01-01

    Full Text Available Thoracic spine chordomas are a rare clinical entity and present several diagnostic and management challenges. Posterior debulking techniques are the traditional approach for the resection of thoracic tumors involving the vertebral body. Anterior approaches to the thoracic spine enable complete tumor resection and interbody fusion. However, this approach has previously required a thoracotomy incision, which is associated with significant perioperative morbidity, pain, and the potential for compromised ventilation and subsequent respiratory sequelae. The extreme lateral approach to the anterior spine has been used to treat degenerative disorders of the lower thoracic and lumbar spine, and reduces the potential complications compared with the anterior transperitoneal/transpleural approach. However, such an approach has not been utilized in the treatment of thoracic chordomas. We describe the first case of an en bloc resection of a thoracic chordoma via a minimally invasive eXtreme lateral interbody fusion approach.

  10. En bloc resection of a thoracic chordoma is possible using minimally invasive anterior access: An 8-year follow-up

    Science.gov (United States)

    Goomany, Anand; Timothy, Jake; Robson, Craig; Rao, Abhay

    2016-01-01

    Thoracic spine chordomas are a rare clinical entity and present several diagnostic and management challenges. Posterior debulking techniques are the traditional approach for the resection of thoracic tumors involving the vertebral body. Anterior approaches to the thoracic spine enable complete tumor resection and interbody fusion. However, this approach has previously required a thoracotomy incision, which is associated with significant perioperative morbidity, pain, and the potential for compromised ventilation and subsequent respiratory sequelae. The extreme lateral approach to the anterior spine has been used to treat degenerative disorders of the lower thoracic and lumbar spine, and reduces the potential complications compared with the anterior transperitoneal/transpleural approach. However, such an approach has not been utilized in the treatment of thoracic chordomas. We describe the first case of an en bloc resection of a thoracic chordoma via a minimally invasive eXtreme lateral interbody fusion approach. PMID:26933363

  11. First experimental results with the Current Limit Avoidance System at the JET tokamak

    Energy Technology Data Exchange (ETDEWEB)

    De Tommasi, G. [Associazione EURATOM-ENEA-CREATE, Università di Napoli Federico II, Via Claudio 21, 80125 Napoli (Italy); Galeani, S. [Dipartimento di Informatica, Sistemi e Produzione, Università di Roma, Tor Vergata, Rome (Italy); Jachmich, S. [Association EURATOM-Belgian State, Koninklijke Militaire School - Ecole Royale Militaire, B-1000 Brussels (Belgium); Joffrin, E. [IRFM-CEA, Centre de Cadarache, 13108 Saint-paul-lez-Durance (France); Lennholm, M. [EFDA Close Support Unit, Culham Science Centre, OX14 3DB Abingdon (United Kingdom); European Commission, B-1049 Brussels (Belgium); Lomas, P.J. [Euratom-CCFE, Culham Science Centre, OX14 3DB Abingdon (United Kingdom); Neto, A.C. [Associazione EURATOM-IST, Instituto de Plasmas e Fusao Nuclear, IST, 1049-001 Lisboa (Portugal); Maviglia, F. [Associazione EURATOM-ENEA-CREATE, Via Claudio 21, 80125 Napoli (Italy); McCullen, P. [Euratom-CCFE, Culham Science Centre, OX14 3DB Abingdon (United Kingdom); Pironti, A. [Associazione EURATOM-ENEA-CREATE, Università di Napoli Federico II, Via Claudio 21, 80125 Napoli (Italy); Rimini, F.G. [Euratom-CCFE, Culham Science Centre, OX14 3DB Abingdon (United Kingdom); Sips, A.C.C. [European Commission, B-1049 Brussels (Belgium); Varano, G.; Vitelli, R. [Dipartimento di Informatica, Sistemi e Produzione, Università di Roma, Tor Vergata, Rome (Italy); Zaccarian, L. [CNRS, LAAS, 7 Avenue du Colonel Roche, F-31400 Toulouse (France); Universitè de Toulouse, LAAS, F-31400 Toulouse (France)

    2013-06-15

    The Current Limit Avoidance System (CLA) has been recently deployed at the JET tokamak to avoid current saturations in the poloidal field (PF) coils when the eXtreme Shape Controller is used to control the plasma shape. In order to cope with the current saturation limits, the CLA exploits the redundancy of the PF coils system to automatically obtain almost the same plasma shape using a different combination of currents in the PF coils. In the presence of disturbances it tries to avoid the current saturations by relaxing the constraints on the plasma shape control. The CLA system has been successfully implemented on the JET tokamak and fully commissioned in 2011. This paper presents the first experimental results achieved in 2011–2012 during the restart and the ITER-like wall campaigns at JET.

  12. Charge state distribution and emission characteristics in a table top reflex discharge—Effect of ion confinement and electrons accelerated across the sheath

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Deepak, E-mail: deepak.kumar@eli-beams.eu; Englesbe, Alexander; Parman, Matthew; Stutman, Dan; Finkenthal, Michael [Department of Physics and Astronomy, The Johns Hopkins University, Baltimore, Maryland 21218 (United States)

    2015-11-15

    Tabletop reflex discharges in a Penning geometry have many applications including ion sources and eXtreme Ultra-Violet (XUV) sources. The presence of primary electrons accelerated across the cathode sheaths is responsible for the distribution of ion charge states and of the unusually high XUV brightness of these plasmas. Absolutely calibrated space resolved XUV spectra from a table top reflex discharge operating with Al cathodes and Ne gas are presented. The spectra are analyzed with a new and complete model for ion charge distribution in similar reflex discharges. The plasma in the discharge was found to have a density of ∼10{sup 18 }m{sup −3} with a significant fraction >0.01 of fast primary electrons. The implications of the new model on the ion states achievable in a tabletop reflex plasma discharge are also discussed.

  13. Mapping The Best Practices of XP and Project Management: Well defined approach for Project Manager

    CERN Document Server

    Javed, Muhammad; Hussain, Shahid; Ahmad, Shakeel

    2010-01-01

    Software engineering is one of the most recent additions in various disciplines of system engineering. It has emerged as a key obedience of system engineering in a quick succession of time. Various Software Engineering approaches are followed in order to produce comprehensive software solutions of affordable cost with reasonable delivery timeframe with less uncertainty. All these objectives are only satisfied when project's status is properly monitored and controlled; eXtreme Programming (XP) uses the best practices of AGILE methodology and helps in development of small size software very sharply. In this paper, authors proposed that via XP, high quality software with less uncertainty and under estimated cost can be developed due to proper monitoring and controlling of project. Moreover, authors give guidelines that how activities of project management can be embedded into development life cycle of XP to enhance the quality of software products and reduce the uncertainty.

  14. Productivity of Pair Programming in a Distributed Environment - Results from Two Controlled Case Studies

    Science.gov (United States)

    Pietinen, Sami; Tenhunen, Vesa; Tukiainen, Markku

    Several methods and techniques have surfaced to address the ongoing concerns of quality and productivity of software development. Among these is the Pair Programming (PP) method, which has gained a lot off attention through being an essential part of an agile software development methodology called the eXtreme Programming (XP). In this paper, we present the results of two controlled case studies that investigate the possible productivity improvement through the incorporation of PP over solo programming. The main focus is on implementation task, more specifically in programming, although PP is suitable for other tasks too. Our results show that very high level of PP use might be difficult to achieve in a very tightly scheduled software development project, but some of the benefits can be seen to come true even with proportional use of PP. In our case, PP added the additional effort of 13% over solo programming.

  15. 敏捷型软件开发方法与极限编程概述%An overview of agile methodology and XP

    Institute of Scientific and Technical Information of China (English)

    李航

    2003-01-01

    在当前需求快速变动的背景下,传统的软件工程方法显得难以适应.近年来出现了一类新的轻量级的软件开发方法,它们被统称为敏捷型软件开发方法.介绍了敏捷型软件开发方法的背景、原则和特点,将其与传统软件工程方法作了比较;还重点介绍了当前国外流行的敏捷型软件开发方法:XP(eXtremeProgramming--极限编程)的开发流程和实践准则.

  16. QualitySpy: a framework for monitoring software development processes

    Directory of Open Access Journals (Sweden)

    Marian Jureczko

    2012-03-01

    Full Text Available The growing popularity of highly iterative, agile processes creates increasing need for automated monitoring of the quality of software artifacts, which would be focused on short terms (in the case of eXtreme Programming process iteration can be limited to one week. This paper presents a framework that calculates software metrics and cooperates with development tools (e.g. source version control system and issue tracking system to describe current state of a software project with regard to its quality. The framework is designed to support high level of automation of data collection and to be useful for researchers as well as for industry. The framework is currently being developed hence the paper reports already implemented features as well as future plans. The first release is scheduled for July.

  17. EVALUATION OF THE MOST USED AGILE METHODS (XP, LEAN, SCRUM

    Directory of Open Access Journals (Sweden)

    BODJE N’KAUH NATHAN-REGIS

    2012-01-01

    Full Text Available With the emergence of Agile Software Development technologies, the software community is expecting in a large impact on producing quality. The Agile Software Development ideas were presentedin the form of Agile Manifesto which consists of four values and twelve principles. Toyota System production, set also a series of principles and practices which has lead Toyota Motor Corporationcommonly known simply as Toyota (multinational automaker on the top of the car industry market by achieving a reputation for the production of very high quality vehicles in all countries around the world. The main question that each new technology must pass through with success is: How much it’s worth? This paper propose a model for determining the significance worth of quality into the most used agilemethods (eXtreme programming, Scrum, Lean inspired by the Toyota Production System(TPS.

  18. Aprimorando a Gerência e o Desenvolvimento de Software com Metodologias Ágeis

    Directory of Open Access Journals (Sweden)

    Mauricio Andreazza Sganderla

    2016-07-01

    Full Text Available Este artigo aborda a melhoria da gerência e construção de software utilizando as metodologias ágeis eXtreme Programming e Scrum. São aplicadas as melhores práticas de ambas as metodologias em uma equipe de desenvolvimento de software, em um ambiente em que não havia nenhum processo bem definido de desenvolvimento de software. A escolha pelo uso das metodologias ágeis foi definida, pois atende ao dinamismo do cenário atual, requisitos voláteis, ambiente mais colaborativo e menos burocrático, tendo como objetivo principal o software em funcionamento e que realmente traga retorno ao cliente.

  19. SILEX-I 330-TW, 30-fs Ti:sapphire laser system

    Science.gov (United States)

    Xiaofeng, W.; Xiaojun, H.; Hansheng, P.; Xiaodong, W.; Xiaomin, Z.; Kainan, Z.; Lanqin, G. Y. L.; Xiao, W.; Qihua, Z.; Donghui, L.

    2008-05-01

    The evolution of Ti:Sapphire laser system named SILEX-I(Super Intense Laser for Experiments on eXtreme) with the peak power of 330 TW is presented [2]. SILEX-I includes the femtosecond oscillator, the Offner stretcher, the regenerative amplifier, the pre-amplifier, the main amplifier, the power amplifier, the vacuum compressor and the vacuum target chamber. SILEX-I has three order output power: 6 TW, 30 TW, and hundreds of terawatt. And there are corresponding target chamber at the different power output for the different physical experiments. Some technology are added to the laser system to decrease the deleterious effects such as gain narrowing, gain shifting, high order dispersion.·Now the peak power with 330 TW is obtained, and the pulse width with 29.8 fs after the compressor. The focal intensity is near 1×1021W/cm2 with the focal spot of 5.7 μm.

  20. Language Classification using N-grams Accelerated by FPGA-based Bloom Filters

    Energy Technology Data Exchange (ETDEWEB)

    Jacob, A; Gokhale, M

    2007-09-13

    N-Gram (n-character sequences in text documents) counting is a well-established technique used in classifying the language of text in a document. In this paper, n-gram processing is accelerated through the use of reconfigurable hardware on the XtremeData XD1000 system. Our design employs parallelism at multiple levels, with parallel Bloom Filters accessing on-chip RAM, parallel language classifiers, and parallel document processing. In contrast to another hardware implementation (HAIL algorithm) that uses off-chip SRAM for lookup, our highly scalable implementation uses only on-chip memory blocks. Our implementation of end-to-end language classification runs at 85x comparable software and 1.45x the competing hardware design.

  1. Effects of extremely low frequency magnetic fields on gap junctional intercellular communication and its mechanism

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The study on biological effect of electromagnetic fields has been paid close attention in recent years. Gap junctional intercellular communication (GJIC) plays an important role in the maintenance of cell proliferation and differentiation, and in the multistage process of carcinogenesis. A series of researches showed that xtremely low frequency (ELF) magnetic fields not only enhance the inhibition of GJIC induced by 12-O-tetradecanoylphorbol-13-acetate, but also inhibit GJIC directly when the intensity is equal to or more than 0.4  mT, and that the mechanisms of GJIC inhibition by ELF magnetic fields are due to hyperphosphorylation of connexin 43, which is mediated by protein kinase C-activated signal transduction, and the internalization of connexin 43 from plasma membrane to cytoplasm.

  2. First experimental results with the Current Limit Avoidance System at the JET tokamak

    International Nuclear Information System (INIS)

    The Current Limit Avoidance System (CLA) has been recently deployed at the JET tokamak to avoid current saturations in the poloidal field (PF) coils when the eXtreme Shape Controller is used to control the plasma shape. In order to cope with the current saturation limits, the CLA exploits the redundancy of the PF coils system to automatically obtain almost the same plasma shape using a different combination of currents in the PF coils. In the presence of disturbances it tries to avoid the current saturations by relaxing the constraints on the plasma shape control. The CLA system has been successfully implemented on the JET tokamak and fully commissioned in 2011. This paper presents the first experimental results achieved in 2011–2012 during the restart and the ITER-like wall campaigns at JET

  3. Comparison of coronagraphs for high contrast imaging in the context of Extremely Large Telescopes

    CERN Document Server

    Martínez, P; Kasper, M; Cavarroc, C; Yaitskova, N; Fusco, T; Verinaud, C

    2008-01-01

    We compare coronagraph concepts and investigate their behavior and suitability for planet finder projects with Extremely Large Telescopes (ELTs, 30-42 meters class telescopes). For this task, we analyze the impact of major error sources that occur in a coronagraphic telescope (central obscuration, secondary support, low-order segment aberrations, segment reflectivity variations, pointing errors) for phase, amplitude and interferometric type coronagraphs. This analysis is performed at two different levels of the detection process: under residual phase left uncorrected by an eXtreme Adaptive Optics system (XAO) for a large range of Strehl ratio and after a general and simple model of speckle calibration, assuming common phase aberrations between the XAO and the coronagraph (static phase aberrations of the instrument) and non-common phase aberrations downstream of the coronagraph (differential aberrations provided by the calibration unit). We derive critical parameters that each concept will have to cope with by...

  4. 墨CM57710:10GbE聚合网络界面控制器

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Broadcom日前推出单芯片双端口10GbE聚合网络界面控制器(C-NIC)——BCM57710,以迎合大批量服务器的设计。基于之前两代成熟的NetXtreme II千兆以太网C-NIC技术,Broadcom此次成功发布业界首款10Gbps(千兆比特/每秒)速率的全功能、单芯片聚合网络界面控制器(C-NIC),这款产品不需要外部缓存的支持。

  5. ABB推出针对极端应用环境的AC500XC系列PLC

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    近日,全球500强ABB集团在华推出XC系列PLC产品AC500-XC代表eXtreme Conditions。XC系列PLC让极端环境下的控制变得更轻松、更明显,也更简单直观,可以让用户有效节省在工程设计和操作中的费用。该产品应用领域包括风电控制及保护系统、太阳能电站跟踪器及监控系统、

  6. De-noising the galaxies in the Hubble XDF with EMPCA

    CERN Document Server

    Maturi, Matteo

    2016-01-01

    We present a method to model optical images of galaxies using Expectation Maximization Principal Components Analysis (EMPCA). The method relies on the data alone and does not assume any pre-established model or fitting formula. It preserves the statistical properties of the sample, minimizing possible biases. The precision of the reconstructions appears to be suited for photometric, morphological and weak lensing analysis, as well as the realization of mock astronomical images. Here, we put some emphasis on the latter because weak gravitational lensing is entering a new phase in which systematics are becoming the major source of uncertainty. Accurate simulations are necessary to perform a reliable calibration of the ellipticity measurements on which the final bias depends. As a test case, we process $7038$ galaxies observed with the ACS/WFC stacked images of the Hubble eXtreme Deep Field (XDF) and measure the accuracy of the reconstructions in terms of their moments of brightness, which turn out to be compara...

  7. Peak heart rates at extreme altitudes

    DEFF Research Database (Denmark)

    Lundby, C; Van Hall, Gerrit

    2001-01-01

    We have measured maximal heart rate during a graded maximal bicycle exercise test to exhaustion in five healthy climbers before and during an expedition to Mt. Everest. Maximal heart rates at sea level were 186 (177-204) beats/min(-1) at sea level and 170 (169-182) beats/min(-1) with acute hypoxia....... After 1, 4 and 6 weeks of acclimatization to 5400 m, maximal heart rates were 155 (135-182), 158 (144-182), and 155 (140-183) beats/min(-1), respectively. Heart rates of two of the climbers were measured during their attempt to reach the summit of Mt. Everest without the use of supplemental oxygen....... The peak heart rates at 8,750 m for the two climbers were 142 and 144 beats/min(-1), which were similar to their maximal heart rates during exhaustive bicycle exercise at 5,400 m, the values being 144 and 148 beats/min(-1), respectively. The peak heart rates at 8,750 m are in agreement with other field...

  8. The Evolving Role of Percutaneous Mitral Valve Repair

    Science.gov (United States)

    Stewart, Merrill H.; Jenkins, J. Stephen

    2016-01-01

    Background: Mitral regurgitation (MR) is the second leading cause of valvular heart disease in the United States behind aortic stenosis. The percutaneous repair of the mitral valve (MitraClip, Abbott, Inc.) has been approved in the United States since 2013 as an alternative to traditional mitral valve surgery. However, many questions are left unanswered about when to perform this procedure and whom to perform it on. Methods: We reviewed major published literature on the MitraClip from 2003-2016 to help guide clinical decision-making. A PubMed search was conducted using the phrase “mitraclip” or “percutaneous mitral valve repair” to identify relevant articles pertaining to the clip as well as surgical valve repair. Results: The clinical trials EVEREST I and EVEREST II (Endovascular Valve Edge-to-Edge Repair Study) demonstrated the safety and efficacy of the MitraClip but did not prove its superiority to surgical repair in the population studied. Numerous subsequent registries have suggested that the success of the MitraClip varies with the patient population studied. The currently enrolling Cardiovascular Outcomes for Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional MR (COAPT) trial hopes to answer some of these questions. Conclusion: The MitraClip is a new and exciting technology for percutaneously treating disease processes traditionally managed with surgery. The future of the clip and its patient population is dependent on further studies. PMID:27660576

  9. Medio ambiente fetal Fetal environment

    Directory of Open Access Journals (Sweden)

    César Bernardo Ospina Arcila

    1996-04-01

    Full Text Available Con base en el artículo clásico "Monte Everest in utero" se hace un análisis de la situación que afronta el feto con respecto a la disponibilidad de oxígeno; para una mejor comprensión del sufrimiento fetal se revisan los siguientes conceptos: presión barométrica, presión parcial del oxígeno atmosférico, presión parcial del oxígeno inspirado, presión barométrica intranasal, ecuación del gas alveolar y difusión de gases a través de la membrana alvéolo capilar. Based on the classical paper by Eastman "Mount Everest in utero" an analysis is made of the situation faced by the fetus with respect to the availability of oxygen; for a better under. standing of fetal distress the following concepts are reviewed: barometric pressure, partial pressure of atmosferic oxygen, partial pressure of inspired oxygen, barometric intranasal pressure, alveolar gas equation and gas diffusion through alveolo-capilar membrane.

  10. Joseph Barcroft's studies of high-altitude physiology.

    Science.gov (United States)

    West, John B

    2013-10-15

    Joseph Barcroft (1872-1947) was an eminent British physiologist who made contributions to many areas. Some of his studies at high altitude and related topics are reviewed here. In a remarkable experiment he spent 6 days in a small sealed room while the oxygen concentration of the air gradually fell, simulating an ascent to an altitude of nearly 5,500 m. The study was prompted by earlier reports by J. S. Haldane that the lung secreted oxygen at high altitude. Barcroft tested this by having blood removed from an exposed radial artery during both rest and exercise. No evidence for oxygen secretion was found, and the combination of 6 days incarceration and the loss of an artery was heroic. To obtain more data, Barcroft organized an expedition to Cerro de Pasco, Peru, altitude 4,300 m, that included investigators from both Cambridge, UK and Harvard. Again oxygen secretion was ruled out. The protocol included neuropsychometric measurements, and Barcroft famously concluded that all dwellers at high altitude are persons of impaired physical and mental powers, an assertion that has been hotly debated. Another colorful experiment in a low-pressure chamber involved reducing the pressure below that at the summit of Mt. Everest but giving the subjects 100% oxygen to breathe while exercising as a climber would on Everest. The conclusion was that it would be possible to reach the summit while breathing 100% oxygen. Barcroft was exceptional for his self-experimentation under hazardous conditions.

  11. El Volcán Chimborazo "El Coloso de los Andes”

    Directory of Open Access Journals (Sweden)

    Castro Izurieta Dario Felix

    2016-09-01

    Full Text Available Por muchos años se pensó que el Monte Everest localizado en Nepal podía ser considerado como el punto más alto del mundo en todo sentido; sin embargo, un estudio realizado por el Instituto Geográfico Militar del Ecuador (IGM con ayuda del Instituto Francés de Investigación para el Desarrollo (IRD, el cuál consistió en realizar nuevas mediciones considerando el centro de la Tierra como referencia, arrojaron que el volcán Chimborazo es el punto más alto del planeta superando al Everest por un margen de alrededor de dos kilómetros. Gracias a estos nuevos datos relevantes, el volcán Chimborazo ha hecho eco alrededor del mundo siendo un atractivo para científicos y curiosos en general interesados en saber un poco más sobre la geología y la biología del lugar.

  12. Cine club

    CERN Multimedia

    Cine club

    2016-01-01

    Wednesday 15 June 2016 at 20:00 CERN Council Chamber North Face   Directed by Philipp Stölzl Germany / Austria / Switzerland, 2008, 126 minutes Based on a true story, North Face is an adventure film about a competition to climb the most dangerous rock face in the Alps. Set in 1936, as Nazi propaganda urges the nation's Alpinists to conquer the unclimbed north face of the Swiss massif - the Eiger - two reluctant German climbers begin their daring ascent.. Original version German; English subtitles Wednesday 22 June 2016 at 20:00 CERN Council Chamber Everest   Directed by Baltasar Kormakur UK / USA, 2015, 121 minutes On the morning of May 10, 1996, climbers from two commercial expeditions start their final ascent toward the summit of Mount Everest, the highest point on Earth. With little warning, a violent storm strikes the mountain, engulfing the adventurers in one of the fiercest blizzards ever encountered by man. Challenged by the harshest conditions imaginable, the te...

  13. Phantom studies using a high-resolution CT for ex-vivo imaging of degradable magnesium implants and simulated peri-implant bone formation in rabbit tibiae

    International Nuclear Information System (INIS)

    Purpose: Evaluation of the suitability of the high-resolution CT XtremeCT for ex vivo imaging of degradable magnesium implants with simulated peri-implant bone formation in rabbit tibiae and development of a method for calibrating the mass concentration of a magnesium alloy in an implant volume. Materials and Methods: Using specially designed phantoms, degradable magnesium implants of the alloys LAE442, ZEK100, AX30 and MgCa 0.8 %, without coating and with peri-implant bone formation simulated by a coating, as well as rabbit tibiae were scanned. CT numbers and the contrast-to-noise-ratio (CNR) of the studied materials were determined. The visual distinction between implant and coating was evaluated. To calibrate the implant density, exemplary LAE442 pins with different mass concentrations were scanned using a specially constructed phantom. Subsequently, CT numbers corresponding to the appropriate mass concentration were determined. Results: The implants, coating and substantia corticalis showed a similar density. Visual distinction between coating and implant was strongly dependent on the respective magnesium alloy and chosen scan parameter. A CNR of at least 0.2 was required for a distinction between implant and coating. For the mass concentration, a high CT number linearity (R2 = 0.99) throughout the measuring range (1811 - 1273 mg/cm3 LAE442) was found. Conclusion: As expected, the XtremeCT is primarily suitable for the imaging of bone tissue and implants. Good visual distinction of peri-implant bone formation on magnesium implants in an ex vivo phantom model ranges from possible to difficult depending on the bone density and alloy composition. (orig.)

  14. Phantom studies using a high-resolution CT for ex-vivo imaging of degradable magnesium implants and simulated peri-implant bone formation in rabbit tibiae; Phantomuntersuchungen an einem hochaufloesenden CT zur Ex-vivo-Darstellung von degradierbaren Magnesiumimplantaten und simulierten periimplantaeren Knochenschichten in Kaninchentibiae

    Energy Technology Data Exchange (ETDEWEB)

    Schulman, J.; Goblet, F.; Seifert, H. [Stiftung Tieraerztliche Hochschule Hannover (Germany). Fachgebiet Allgemeine Radiologie und Medizinische Physik; Meyer-Lindenberg, A. [Stiftung Tieraerztliche Hochschule Hannover (Germany). Klinik fuer Kleintiere; Bormann, D. [Leibniz Univ. Hannover (Germany). Inst. fuer Werkstoffkunde; Stiller, W. [Universitaetsklinikum Heidelberg (Germany). Diagnostische und Interventionelle Radiologie

    2012-05-15

    Purpose: Evaluation of the suitability of the high-resolution CT XtremeCT for ex vivo imaging of degradable magnesium implants with simulated peri-implant bone formation in rabbit tibiae and development of a method for calibrating the mass concentration of a magnesium alloy in an implant volume. Materials and Methods: Using specially designed phantoms, degradable magnesium implants of the alloys LAE442, ZEK100, AX30 and MgCa 0.8 %, without coating and with peri-implant bone formation simulated by a coating, as well as rabbit tibiae were scanned. CT numbers and the contrast-to-noise-ratio (CNR) of the studied materials were determined. The visual distinction between implant and coating was evaluated. To calibrate the implant density, exemplary LAE442 pins with different mass concentrations were scanned using a specially constructed phantom. Subsequently, CT numbers corresponding to the appropriate mass concentration were determined. Results: The implants, coating and substantia corticalis showed a similar density. Visual distinction between coating and implant was strongly dependent on the respective magnesium alloy and chosen scan parameter. A CNR of at least 0.2 was required for a distinction between implant and coating. For the mass concentration, a high CT number linearity (R{sup 2} = 0.99) throughout the measuring range (1811 - 1273 mg/cm{sup 3} LAE442) was found. Conclusion: As expected, the XtremeCT is primarily suitable for the imaging of bone tissue and implants. Good visual distinction of peri-implant bone formation on magnesium implants in an ex vivo phantom model ranges from possible to difficult depending on the bone density and alloy composition. (orig.)

  15. Career perspective: John B West.

    Science.gov (United States)

    West, John B

    2012-11-07

    I have been fortunate to work in two areas of extreme physiology and medicine: very high altitude and the microgravity of spaceflight. My introduction to high altitude medicine was as a member of Sir Edmund Hillary's Silver Hut Expedition in 1960-1961 when a small group of physiologists spent the winter and spring at an altitude of 5,800 m just south of Mt. Everest. The physiological objective was to obtain a better understanding of the acclimatization process of lowlanders during exposure to a very high altitude for several months. As far as we knew, no one had ever spent so long at such a high altitude before. The success of this expedition prompted me to organize the 1981 American Medical Research Expedition to Everest where the scientific objective was to determine the physiological changes that allow humans to survive in the extreme hypoxia of the highest point on earth. There is good evidence that this altitude is very near the limit of human tolerance to oxygen deprivation. Much novel information was obtained including an extraordinary degree of hyperventilation which reduced the alveolar partial pressure of carbon dioxide (Pco2) to about 8 mmHg (1.1 kPa) on the summit, and this in turn allowed the alveolar partial pressure of oxygen, PO2, to be maintained at a viable level of about 35 mmHg (4.7 kPa). The low Pco2 caused a severe degree of respiratory alkalosis with an arterial pH exceeding 7.7. These were the first physiological measurements to be made on the Everest summit, and essentially, none has been made since. The second extreme environment is microgravity. We carried out an extensive series of measurements on astronauts in the orbiting laboratory known as SpaceLab in the 1990s. Many aspects of pulmonary function are affected by gravity, so it was not surprising that many changes were found. However, overall gas exchange remained efficient. Some of the findings such as an anomalous behavior of inhaled helium and sulfur hexafluoride have still not

  16. Himalayas as seen from STS-66 shuttle Atlantis

    Science.gov (United States)

    1994-01-01

    View is southeastward across China (Tibet), half of Nepal and India. The partly frozen lake near the center of the frame is Pei-Ku T'so ('Bos-tie Lake'). The central Himalaya stretches from Mount Everest on the left past Annapurna on the right. Large tributaries converge to form the Ganges River, flowing through the lowland basin south of the Himalaya. This photograph illustrates the rain shadow effect of the Himalaya Chain; wet, warm air from the Indian Ocean is driven against the mountains, lifted, and drained of water that forms ice caps, the abundant rivers, and forests of the foothills. In contrast the high plateau of Tibet is arid, composed largely of topographically-closed basins because stream flow is inadequate to form integrated drainage networks.

  17. Mountaineering fatalities on Aconcagua: 2001-2012.

    Science.gov (United States)

    Westensee, Jeffrey; Rogé, Ignacio; Van Roo, Jon D; Pesce, Carlos; Batzli, Sam; Courtney, D Mark; Lazio, Matthew P

    2013-09-01

    High altitude mountaineering is a dangerous endeavor due to the hypoxic hypobaric environment, extreme weather, and technical skills required. One of the seven summits, Aconcagua (6962 m) is the highest mountain outside of Asia. Its most popular route is nontechnical, attracting >3000 mountaineers annually. Utilizing data from the Servicio Médico Aconcagua (park medical service), we performed a retrospective descriptive analysis with the primary objective of deriving a fatality rate on Aconcagua from 2001 to 2012. The fatality rate on Aconcagua was then compared to other popular mountains. For climbers who died, we report all available demographic data, mechanisms of death, and circumstances surrounding the death. Between 2001 and 2012, 42,731 mountaineers attempted to summit Aconcagua. There were 33 fatalities. The fatality rate was 0.77 per 1000, or 0.077%. The fatality rate on Aconcagua is lower than that on Everest or Denali but higher than that on Rainier. PMID:24028641

  18. Glacier variations and climate warming and drying in the central Himalayas

    Institute of Scientific and Technical Information of China (English)

    REN Jiawen; QIN Dahe; KANG Shichang; HOU Shugui; PU Jianchen; JING Zhefan

    2004-01-01

    Repeat measurements of glacier terminus positions show that glaciers in the central Himalayas have been in a continuous retreat situation in the past decades. The average retreat rate is 5.5-8.7 m/a in Mt. Qomolangma (Everest) since the 1960s and 6.4 m/a in Mt. Xixiabangma since the 1980s. In recent years, the retreat rate is increasing. Ice core studies revealed that the accumulation rate of glaciers has a fluctuating decrease trend in the last century with a rapid decrease in the 1960s and a relatively steady low value afterwards. Meteorological station record indicates that the annual mean temperature has a slow increase trend but summer temperature had a larger increase in the past 30 a. All these suggest that the glacier retreat results from precipitation decrease in combination with temperature increase, and hence glacier shrinkage in this region will speed up if the climatic warming and drying continues.

  19. Sensitivity and uncertainty analysis applied to a repository in rock salt

    International Nuclear Information System (INIS)

    This document describes the sensitivity and uncertainty analysis with UNCSAM, as applied to a repository in rock salt for the EVEREST project. UNCSAM is a dedicated software package for sensitivity and uncertainty analysis, which was already used within the preceding PROSA project. The use of UNCSAM provides a flexible interface to EMOSECN by substituting the sampled values in the various input files to be used by EMOSECN; the model calculations for this repository were performed with the EMOSECN code. Preceding the sensitivity and uncertainty analysis, a number of preparations has been carried out to facilitate EMOSECN with the probabilistic input data. For post-processing the EMOSECN results, the characteristic output signals were processed. For the sensitivity and uncertainty analysis with UNCSAM the stochastic input, i.e. sampled values, and the output for the various EMOSECN runs have been analyzed. (orig.)

  20. Secrets to Successful Earth and Sky Photography

    Science.gov (United States)

    Tafreshi, Babak A.

    In the absolute silence of a desert night, surrounded by an arena of celestial beauties, a gentle breeze shifts the tiny grains of sand around me. There is a patchy glow of light visible all across the eastern horizon. It is gradually ascending over the sand dunes. The glow represents billions of stars in our home galaxy rising above the horizon of our planet. I have seen such dream-like starry scenes from many locations; from the boundless dark skies of the African Sahara when the summer Milky Way was arching over giant sandstones, to the shimmering beauty of the Grand Canyon under moonlight, and the transparent skies of the Himalayas when the bright stars of winter were rising above where the highest peak on Earth (Mt. Everest) meets the sky. These are forever-engraved moments in my memory. Astrophotography is not only about recording the celestial world. It can lead you to a life of adventure and discovery (Fig. 1).

  1. Late calcific mitral stenosis after MitraClip procedure in a dialysis-dependent patient.

    Science.gov (United States)

    Pope, Nicolas H; Lim, Scott; Ailawadi, Gorav

    2013-05-01

    The EVEREST II trial investigated the MitraClip (Abbott Vascular, Menlo Park, CA) in patients with severe mitral regurgitation (MR) undergoing surgical procedures. Although mitral stenosis was not reported in this cohort, this trial excluded patients receiving dialysis. We report a case of a 43-year-old HIV-positive, dialysis-dependent patient with nonischemic cardiomyopathy and severe MR, who was considered at high operative risk because of frailty. She was treated with a MitraClip as part of the REALISM high-risk registry. Her symptomatic MR improved but severe symptomatic mitral stenosis developed 28 months after the MitraClip procedure. At that point, she was felt to be a better operative candidate but required open mitral valve replacement. Pathologic examination demonstrated significant calcification of the leaflets around the MitraClip devices.

  2. Landscapes of Mars A Visual Tour

    CERN Document Server

    Vogt, Gregory L

    2008-01-01

    Landscapes of Mars is essentially a picture book that provides a visual tour of Mars. All the major regions and topographical features will be shown and supplemented with chapter introductions and extended captions. In a way, think of it as a visual tourist guide. Other topics covered are Martian uplands on the order of the elevation of Mt. Everest, Giant volcanoes and a rift system, the Grand Canyon of Mars, craters and the absence of craters over large regions (erosion), and wind shadows around craters, sand dunes, and dust devils. The book includes discussions on the search for water (braided channels, seepage, sedimentary layering, etc.) as well as on the Viking mission search for life, Mars meteorite fossil bacteria controversy, and planetary protection in future missions. The book concludes with an exciting gallery of the best 3D images of Mars making the book a perfect tool for understanding Mars and its place in the solar system.

  3. Geoid of Nepal from airborne gravity survey

    DEFF Research Database (Denmark)

    Forsberg, René; Olesen, Arne Vestergaard; Einarsson, Indriði;

    2011-01-01

    An airborne gravity survey of Nepal was carried out December 2010 in a cooperation between DTU-Space, Nepal Survey Department, and NGA, USA. The entire country was flown with survey lines spaced 6 nm with a King Air aircraft, with a varying flight altitude from 4 to 10 km. The survey operations...... were a major challenge due to excessive jet streams at altitude as well as occasional excessive mountain waves. Despite the large 400 mGal+ range of gravity anomaly changes from the Indian plains to the Tibetan Plateau, results appear accurate to a few mGal, with proper evaluation from cross...... as well as recent GPS-heights of Mt. Everest. The new airborne data also provide an independent validation of GOCE gravity field results at the local ~100 km resolution scale....

  4. Rb-Sr ages of the biotite and muscovite of the Himalayas, eastern Nepal

    International Nuclear Information System (INIS)

    Rb-Sr ages of biotite from the southern flank of Mt. Everest, eastern Nepal, range from 14.1 to 1.3 m.y., the youngest biotite coexists with muscovite of 7.3 m.y. These different ages for different samples reflect the difference in cooling history related to the uplift of the Himalayas. The biotite ages decrease with increasing distance from the high mountain range, suggesting that the high range, i.e., the northern area, was uplifted earlier than the southern area. The relationship between the ages and altitutes of sampling sites indicates that the uplift rate of the northern area was 0.60 mm/yr. (author)

  5. Box vs styck : Ett beslutsunderlag till Stadium AB gällande styckhantering i distributionslagret som alternativ till boxar

    OpenAIRE

    Örtengren, Malin; Torstensson, Tobias

    2007-01-01

    Stadium AB är ett av de största detaljhandelsföretagen i Sverige, som designar, köper och säljer sportutrustning samt sportmodeprodukter. I Stadiums butiker säljs både produkter från märkesleverantörer, exempelvis Adidas och Nike, samt varumärken med egen design, exempelvis SOC, 4D och Everest. Stadium befinner sig i en bransch där kundernas efterfrågan ständigt förändras med mode och säsong. Detta gör branschen komplex och medför att det ställs stora krav på varuförsörjningen till butikerna ...

  6. Study on the heights of the highest mountains of Mars and the Earth and their difference%火星和地球上山峰最高高度及其差异研究

    Institute of Scientific and Technical Information of China (English)

    陈出新; 常震

    2015-01-01

    The radius of Mars is only half of that of Earth,while the height of Mount Olympus,the highest mountain on Mars,is more than twice of that of Everest on Earth.There are still some peaks on Mars which are much higher than Everest. To explain the appearance of mountains or protrusions disproportional to the scale of the planet,a stress model of a mountain was set up.It was found that the main factor that affects the highest mountains’height is gravitational acceleration.The smaller the planet, the smaller its surface gravitational acceleration,and the more prominent the protrusions on its surface. The depth of the deepest trench on Earth was also estimated using the same method;the result is close to reality.%火星的半径只有地球半径的一半多一点,而火星的最高峰奥林匹斯山比地球的最高峰珠穆朗玛峰的两倍还高,火星上还有不少比珠峰还要高得多的山峰。为解释这种与天体尺度不成比例的山峰或凸起的出现原因,建立了一个山峰的应力模型,发现影响山峰高度的主要因素是重力加速度。越是小的天体,它的表面重力加速度越小,表面的凸起就越显著。同一模型亦较好地估算出与实际相近的地球最深海沟的深度。

  7. Reduced melt on debris-covered glaciers: investigations from Changri Nup Glacier, Nepal

    Science.gov (United States)

    Vincent, Christian; Wagnon, Patrick; Shea, Joseph M.; Immerzeel, Walter W.; Kraaijenbrink, Philip; Shrestha, Dibas; Soruco, Alvaro; Arnaud, Yves; Brun, Fanny; Berthier, Etienne; Futi Sherpa, Sonam

    2016-08-01

    Approximately 25 % of the glacierized area in the Everest region is covered by debris, yet the surface mass balance of debris-covered portions of these glaciers has not been measured directly. In this study, ground-based measurements of surface elevation and ice depth are combined with terrestrial photogrammetry, unmanned aerial vehicle (UAV) and satellite elevation models to derive the surface mass balance of the debris-covered tongue of Changri Nup Glacier, located in the Everest region. Over the debris-covered tongue, the mean elevation change between 2011 and 2015 is -0.93 m year-1 or -0.84 m water equivalent per year (w.e. a-1). The mean emergence velocity over this region, estimated from the total ice flux through a cross section immediately above the debris-covered zone, is +0.37 m w.e. a-1. The debris-covered portion of the glacier thus has an area-averaged mass balance of -1.21 ± 0.2 m w.e. a-1 between 5240 and 5525 m above sea level (m a.s.l.). Surface mass balances observed on nearby debris-free glaciers suggest that the ablation is strongly reduced (by ca. 1.8 m w.e. a-1) by the debris cover. The insulating effect of the debris cover has a larger effect on total mass loss than the enhanced ice ablation due to supraglacial ponds and exposed ice cliffs. This finding contradicts earlier geodetic studies and should be considered for modelling the future evolution of debris-covered glaciers.

  8. Same ammo, different weapons: enzymatic extracts from two apple genotypes with contrasted susceptibilities to fire blight (Erwinia amylovora) differentially convert phloridzin and phloretin in vitro.

    Science.gov (United States)

    Gaucher, Matthieu; Dugé de Bernonville, Thomas; Guyot, Sylvain; Dat, James F; Brisset, Marie-Noëlle

    2013-11-01

    The necrogenic bacterium Erwinia amylovora responsible for the fire blight disease causes cell death in apple tissues to enrich intercellular spaces with nutrients. Apple leaves contain large amounts of dihydrochalcones (DHCs), including phloridzin and its aglycone phloretin. Previous work showed an important decrease in the constitutive DHCs stock in infected leaves, probably caused by transformation reactions during the infection process. At least two flavonoid transformation pathways have been described so far: deglucosylation and oxidation. The aim of the present study was to determine whether DHCs are differentially converted in two apple genotypes displaying contrasted susceptibilities to the disease. Different analyses were performed: i) enzymatic activity assays in infected leaves, ii) identification/quantification of end-products obtained after in vitro enzymatic reactions with DHCs, iii) evaluation of the bactericidal activity of end-products. The results of the enzymatic assays showed that deglucosylation was dominant over oxidation in the susceptible genotype MM106 while the opposite was observed in the resistant genotype Evereste. These data were confirmed by LC-UV/Vis-MS analysis of in vitro reaction mixtures, especially because higher levels of o-quinoid oxidation products of phloretin were measured by using the enzymatic extracts of Evereste infected leaves. Their presence correlated well with a strong bactericidal activity of the reaction mixtures. Thus, our results suggest that a differential transformation of DHCs occur in apple genotypes with a potential involvement in the establishment of the susceptibility or the resistance to fire blight, through the release of glucose or of highly bactericidal compounds respectively. PMID:23561298

  9. To localise or to be localised with WiFi in the Hubei museum?

    Science.gov (United States)

    Verbree, E.; Zlatanova, S.; van Winden, K. B. A.; van der Laan, E. B.; Makri, A.; Taizhou, L.; Haojun, A.

    2013-11-01

    Indoor localisation is in demand for a variety of applications within the built environment. An overall solution based on a single technology has not yet been determined. The aim of this paper is to gain insight on Signal Strength monitoring by a special kind of WiFi Monitors in comparison to the commonly known fingerprinting method for the purpose of a 3D indoor navigation system. Ttwo different WiFi based localisation techniques are tested during the MSc Geomatics DaRen Syntheses Project in the Hubei Provincial Museum, China. The first method detects the beacon frames send by smartphones, laptops and other WiFi enabled devices in range using Libelium Meshlium Xtreme monitors. Their MAC addresses and the signal strength is measured by the Meshlium Xtreme and stored on an external database. We call this method WiFi monitoring. The second method a Wifi enabled device, like a smartphone, measures the signal strength of multiple Wifi Access Points in range to localise itself based on a previously created radio map. This method is known as WiFi fingerprinting. Both methods have some advantages and disadvantages. Advantages of the common way of WiFi fingerprinting are that the implementation costs are relatively low, because it is usually possible to use (a part of) the existing WiFi AP infrastructure. WiFi fingerprinting can reach a relatively high accuracy in the order of magnitude of meters. Finally, the location granularity can be adjusted to what is necessary for the purpose of the indoor localisation. This makes it employable for a wide range of purposes. The question remains how suitable these methods are for a 3D indoor navigation system for the Hubei provincial museum. One important aspect is the localisation-granularity necessary for the application. In a museum it is not necessary to know the exact X,Y position of a user (such high accuracy is unnecessary), more important is to know in which room the user is located so the information on exhibitions can be

  10. In vitro and in vivo metabolism studies of dimethazine.

    Science.gov (United States)

    Geldof, Lore; Tudela, Eva; Lootens, Leen; van Lysebeth, Jasper; Meuleman, Phillip; Leroux-Roels, Geert; van Eenoo, Peter; Deventer, Koen

    2016-08-01

    The use of anabolic steroids is prohibited in sports. Effective control is done by monitoring their metabolites in urine samples collected from athletes. Ethical objections however restrict the use of designer steroids in human administration studies. To overcome these problems alternative in vitro and in vivo models were developed to identify metabolites and to assure a fast response by anti-doping laboratories to evolutions on the steroid market. In this study human liver microsomes and an uPA(+/+) -SCID chimeric mouse model were used to elucidate the metabolism of a steroid product called 'Xtreme DMZ'. This product contains the designer steroid dimethazine (DMZ), which consists of two methasterone molecules linked by an azine group. In the performed stability study, degradation from dimethazine to methasterone was observed. By a combination of LC-High Resolution Mass Spectrometry (HRMS) and GC-MS(/MS) analysis methasterone and six other dimethazine metabolites (M1-M6), which are all methasterone metabolites, could be detected besides the parent compound in both models. The phase II metabolism of dimethazine was also investigated in the mouse urine samples. Only metabolites M1 and M2 were exclusively detected in the glucuro-conjugated fraction; all other compounds were also found in the free fraction. For effective control of DMZ misuse in doping control samples, screening for methasterone and methasterone metabolites should be sufficient. Copyright © 2016 John Wiley & Sons, Ltd. PMID:26663462

  11. Application of Open Source Technologies for Oceanographic Data Analysis

    Science.gov (United States)

    Huang, T.; Gangl, M.; Quach, N. T.; Wilson, B. D.; Chang, G.; Armstrong, E. M.; Chin, T. M.; Greguska, F.

    2015-12-01

    NEXUS is a data-intensive analysis solution developed with a new approach for handling science data that enables large-scale data analysis by leveraging open source technologies such as Apache Cassandra, Apache Spark, Apache Solr, and Webification. NEXUS has been selected to provide on-the-fly time-series and histogram generation for the Soil Moisture Active Passive (SMAP) mission for Level 2 and Level 3 Active, Passive, and Active Passive products. It also provides an on-the-fly data subsetting capability. NEXUS is designed to scale horizontally, enabling it to handle massive amounts of data in parallel. It takes a new approach on managing time and geo-referenced array data by dividing data artifacts into chunks and stores them in an industry-standard, horizontally scaled NoSQL database. This approach enables the development of scalable data analysis services that can infuse and leverage the elastic computing infrastructure of the Cloud. It is equipped with a high-performance geospatial and indexed data search solution, coupled with a high-performance data Webification solution free from file I/O bottlenecks, as well as a high-performance, in-memory data analysis engine. In this talk, we will focus on the recently funded AIST 2014 project by using NEXUS as the core for oceanographic anomaly detection service and web portal. We call it, OceanXtremes

  12. Revising time series of the Elbe river discharge for flood frequency determination at gauge Dresden

    Directory of Open Access Journals (Sweden)

    S. Bartl

    2009-11-01

    Full Text Available The German research programme RIsk MAnagment of eXtreme flood events has accomplished the improvement of regional hazard assessment for the large rivers in Germany. Here we focused on the Elbe river at its gauge Dresden, which belongs to the oldest gauges in Europe with officially available daily discharge time series beginning on 1 January 1890. The project on the one hand aimed to extend and to revise the existing time series, and on the other hand to examine the variability of the Elbe river discharge conditions on a greater time scale. Therefore one major task were the historical searches and the examination of the retrieved documents and the contained information. After analysing this information the development of the river course and the discharge conditions were discussed. Using the provided knowledge, in an other subproject, a historical hydraulic model was established. Its results then again were used here. A further purpose was the determining of flood frequency based on all pre-processed data. The obtained knowledge about historical changes was also used to get an idea about possible future variations under climate change conditions. Especially variations in the runoff characteristic of the Elbe river over the course of the year were analysed. It succeeded to obtain a much longer discharge time series which contain fewer errors and uncertainties. Hence an optimized regional hazard assessment was realised.

  13. ELTs Adaptive Optics for Multi-Objects 3D Spectroscopy Key Parameters and Design Rules

    CERN Document Server

    Neichel, B; Fusco, T; Gendron, E; Puech, M; Rousset, G; Hammer, F

    2006-01-01

    In the last few years, new Adaptive Optics [AO] techniques have emerged to answer new astronomical challenges: Ground-Layer AO [GLAO] and Multi-Conjugate AO [MCAO] to access a wider Field of View [FoV], Multi-Object AO [MOAO] for the simultaneous observation of several faint galaxies, eXtreme AO [XAO] for the detection of faint companions. In this paper, we focus our study to one of these applications : high red-shift galaxy observations using MOAO techniques in the framework of Extremely Large Telescopes [ELTs]. We present the high-level specifications of a dedicated instrument. We choose to describe the scientific requirements with the following criteria : 40% of Ensquared Energy [EE] in H band (1.65um) and in an aperture size from 25 to 150 mas. Considering these specifications we investigate different AO solutions thanks to Fourier based simulations. Sky Coverage [SC] is computed for Natural and Laser Guide Stars [NGS, LGS] systems. We show that specifications are met for NGS-based systems at the cost of ...

  14. Enabling the 22nm node via grazing incidence collectors integrated into the DPP source for EUVL HVM

    Science.gov (United States)

    Bianucci, G.; Bragheri, A.; Cassol, G. L.; Ghislanzoni, R.; Mazzoleni, R.; Zocchi, F. E.

    2011-04-01

    Media Lario Technologies (MLT) has enabled the Extreme Ultraviolet Lithography (EUVL) roadmap with its grazing incidence collectors installed in all DPP sources since 2006. Furthermore, with several 100 WIF capable production grazing incidence collectors shipped in 2010, MLT is ready to support the start of High Volume Manufacturing (HVM). With a point-source collection efficiency of 25% and 6 kW power loading capability, the 9-shell collector design is capable of delivering 100 W in-band EUV power through the intermediate focus aperture. The customized reflective layer and the debris mitigation technology enable the 1-year lifetime objective under full production operating conditions. Integration of the grazing incidence collector in XTREME technologies' (XT) DPP source attached to ASML's NXE:3100 scanner has provided initial validation of the optical, thermal, and lifetime design objectives. In full HVM regime, we anticipate that the collector power loading will progressively reach 20 kW to enable 500 W inband EUV peak power at intermediate focus. We have started the development of a thermal management design maintaining the current optical stability with a collector power loading of 30 kW, thus meeting the aggressive HVM requirements.

  15. Revisiting the comparison between the Shack-Hartmann and the pyramid wavefront sensors via the Fisher information matrix.

    Science.gov (United States)

    Plantet, C; Meimon, S; Conan, J-M; Fusco, T

    2015-11-01

    Exoplanet direct imaging with large ground based telescopes requires eXtreme Adaptive Optics that couples high-order adaptive optics and coronagraphy. A key element of such systems is the high-order wavefront sensor. We study here several high-order wavefront sensing approaches, and more precisely compare their sensitivity to noise. Three techniques are considered: the classical Shack-Hartmann sensor, the pyramid sensor and the recently proposed LIFTed Shack-Hartmann sensor. They are compared in a unified framework based on precise diffractive models and on the Fisher information matrix, which conveys the information present in the data whatever the estimation method. The diagonal elements of the inverse of the Fisher information matrix, which we use as a figure of merit, are similar to noise propagation coefficients. With these diagonal elements, so called "Fisher coefficients", we show that the LIFTed Shack-Hartmann and pyramid sensors outperform the classical Shack-Hartmann sensor. In photon noise regime, the LIFTed Shack-Hartmann and modulated pyramid sensors obtain a similar overall noise propagation. The LIFTed Shack-Hartmann sensor however provides attractive noise properties on high orders.

  16. HI in XMD Galaxies III. GMRT observations of BCG HS0822+3542

    CERN Document Server

    Chengalur, J N; Martin, J M; Kniazev, A Yu; Chengalur, Jayaram N.

    2006-01-01

    We present Giant Metrewave Radio Telescope (GMRT) HI 21-cm line data for the smallest known eXtremely Metal Deficient (XMD) blue compact galaxy (BCG) HS0822+3542. From HST imaging it has been suggested that HS0822+3542 actually consists of two still smaller (~ 100pc sized) ultra-compact dwarfs that are in the process of merging. The brighter of these two putative ultra compact dwarfs has an ocular appearance, similar to that seen in galaxies that have suffered a penetrating encounter with a smaller companion. From our HI imaging we find that the gas distribution and kinematics in this object are similar to that of other low mass galaxies, albeit with some evidence for tidal disturbance. On the other hand, the HI emission has an angular size ~25 times larger than that of the putative ultra-compact dwarfs. The optical emission is also offset from the centre of the HI emission. HS0822+3542 is located in the Lynx-Cancer void, but has a nearby companion LSB dwarf galaxy SAO0822+3545. In light of all this we also c...

  17. Atmospheric Aerosol Attenuation Measurements at the Pierre Auger Observatory

    CERN Document Server

    Valore, Laura

    2014-01-01

    The Fluorescence Detector (FD) of the Pierre Auger Observatory provides a nearly calorimetric measurement of the primary particle energy, since the fluorescence light produced is proportional to the energy dissipated by an Extensive Air Shower (EAS) in the atmosphere. The atmosphere therefore acts as a giant calorimeter, whose properties need to be well known during data taking. Aerosols play a key role in this scenario, since their effect on light transmission is highly variable even on a time scale of one hour, and the corresponding correction to EAS energy can range from a few percent to more than 40%. For this reason, hourly Vertical Aerosol Optical Depth (taer(h)) profiles are provided for each of the four FD stations. Starting from 2004, up to now 9 years of taer(h) profiles have been produced using data from the Central Laser Facility (CLF) and the eXtreme Laser Facility (XLF) of the Pierre Auger Observatory. The two laser facilities, the techniques developed to measure taer(h) profiles using laser dat...

  18. K-Stacker, a new way of detecting and characterizing exoplanets with high contrast imaging instruments

    CERN Document Server

    Coroller, H Le; Arnold, L; Dohlen, K; Fusco, T; Sauvage, J F; Vigan, A

    2015-01-01

    This year, a second generation of coronagraphs dedicated to high-contrast direct imaging of exoplanets is starting operations. Among them, SPHERE, installed at the focus of the UT3 Very Large Telescope, reaches unprecedented contrast ratios up to $10^{-6}$ -$ 10^{-7}$, using eXtreme Adaptive Optics and the Angular Differential Imaging (ADI) techniques. In this paper, we present a new method called Keplerian-Stacker that improves the detection limit of high contrast instruments like SPHERE, by up to a factor of 10. It consists of observing a star on a long enough period to let a hypothetical planet around that star move along its orbit. Even if in each individual observation taken during one night, we do not detect anything, we show that it is possible, using an optimization algorithm, to re-center the images according to keplerian motions (ex: 10-100 images taken over a long period of typically 1-10 years) and detect planets otherwise unreachable. This method can be used in combination with the ADI technics (...

  19. The fate of a red nugget: In-situ star formation of satellites around a massive compact galaxy

    CERN Document Server

    Morishita, Takahiro

    2015-01-01

    To study the accretion phase for local massive galaxies, we search accreting satellites around a massive compact galaxy (M_*~3.9x10^10Msun), spectroscopically confirmed (z_spec-1.9213) in the eXtreme Deep Field, which has been originally reported in Szomoru et al. We detect 1369 satellite candidates within the projected virial radius (rvir~300 kpc) of the compact galaxy in the all-combined ACS image with 5sigma-limiting magnitude of mACS~30.6 ABmag, which corresponds to ~1.6x10^7M_sun at the redshift. The photometric redshift measured with 12 multi-band images confirms 34 satellites out of the candidates. Most of the satellites are found to have the rest-frame colors consistent with star forming galaxies. We investigate the relation between stellar mass and star formation rate (the star formation main sequence), and find the steeper slope at the low-mass end (<10^8M_sun), while more massive satellites are consistently on the sequence reported in previous studies. Within the uncertainties of star formation ...

  20. Efficient Source of Cells in Proximal Oviduct for Testing Non-Viral Expression Constructs in the Chicken Bioreactor Model and for Other in Vitro Studies.

    Science.gov (United States)

    Stadnicka, Katarzyna; Bodnar, Magdalena; Marszałek, Andrzej; Bajek, Anna; Drewa, Tomasz; Płucienniczak, Grazyna; Chojnacka-Puchta, Luiza; Cecuda-Adamczewska, Violetta; Dunisławska, Aleksandra; Bednarczyk, Marek

    2016-01-01

    This work shows the usefulness of chicken oviduct epithelial cells (COEC) in evaluating the efficacy of non-viral expression vectors carrying human therapeutic genes. Secondly, an efficient source of progenitor COEC for in vitro studies is described. Within the distal part of the oviduct, weak to moderate expression of a trans membrane glycoprotein (CD44) was observed. Single cells presenting only weak expression of CD44 were found in magnum sections. in vitro cultured oviduct cells originating from the distal oviduct were suitable for subculturing and showed a stable proliferation potential up to the 2nd passage. However, the pavimentous epithelial-like morphology of COEC was progressively lost over time and mainly a fibroblast-like monolayer was established in consecutive passages. Moreover, various commercial transfection agents including FuGENE6 and XtremeGENE9 DNA were used to optimize delivery of human interferon alfa-2a, (IFNα2a) a therapeutic protein gene under an ovalbumin promoter. The transfection efficiency of adherent COEC was estimated for up to 40% at a ratio of 6:1 of transfectant to pOVA5EIFN + GFP plasmid. Expression of IFNα2a was confirmed by western blotting in transformed COEC. In conclusion, the population of epithelial progenitor cells sourced from the distal oviduct can significantly contribute to in vitro culture of COEC, representing an efficient model to develop the production of avian bioreactors and other in vitro studies related to oviduct tissue. PMID:27172711

  1. INNOVATIVE TEACHING AND LEARNING TOOLS FOR FOUNDATION IN ENGINEERING EDUCATION

    Directory of Open Access Journals (Sweden)

    CHRISTOPHER M. K. CHEW

    2013-04-01

    Full Text Available Students in Malaysia who aspire to pursue a degree in engineering have the option of enrolling in either a specific foundation programme or a generic pre-university programme, which while offering more flexibility, does not offer the focus of an engineering specific foundation programme. This paper outlines the design of a new foundation programme that is aimed at preparing year 11 students to smoothly transit into an engineering programme of their choice. This programme has three main features, firstly, it is project-based and designed according to the CDIO Framework, secondly, the theory part of the programme is delivered using technology, namely iBook and MOOCs, and thirdly it has and eXtreme Learning Process (XLP. The surveys done to assess the trial runs of the XLP and the iBook indicate that students found the methodology to be both useful and interesting. The first batch of students will join in July 2013 and more data will be available by then.

  2. The clustering and halo occupation distribution of Lyman-break galaxies at z ~ 4

    CERN Document Server

    Park, Jaehong; Wyithe, J Stuart B; Lacey, C G; Baugh, C M; Barone-Nugent, R L; Trenti, M; Bouwens, R J

    2015-01-01

    We investigate the clustering of Lyman-break galaxies (LBGs) at z ~ 4. Using the hierarchical galaxy formation model GALFORM, we predict the angular correlation function (ACF) of LBGs and compare this with the measured ACF from survey fields including the Hubble eXtreme Deep Field (XDF) and CANDELS field. We find that the predicted ACFs are in good agreement with the measured ones. However, the predicted ACFs show a weaker dependence on luminosity than is inferred from observations. We show that the fraction of satellite LBGs is important for determining the amplitude of the ACF on small scales. We find that central LBGs at z ~ 4 predominantly reside in haloes of mass ~ 10e11 - 10e12 M_{sun}/h and that satellites reside in larger haloes of mass ~ 10e12 - 10e13 M_{sun}/h. The model predicts fewer bright satellite LBGs at z ~ 4 than are inferred from clustering measurements. We investigate the effect of the photometric scatter in the observations on the ACF predictions. We find that the observational uncertaint...

  3. Direct Imaging of Exoplanets, from very large to extremely large telescopes

    Science.gov (United States)

    Kasper, M.

    2015-10-01

    Presently, dedicated instruments at 8-m class telescopes (SPHERE for the VLT, GPI for Gemini) are about to discover and explore self-luminous giant planets by direct imaging and spectroscopy. In a decade, the next generation of 30m-40m ground-based Extremely Large Telescopes (ELTs) have the potential to dramatically enlarge the discovery space towards older giant planets seen in the reflected light and ultimately even a small number of rocky planets. In order to fulfill the demanding contrast requirements of a part in a million to a part in a billion at separations of one tenth of an arcsecond, the seeing limited PSF contrast must gradually be improved by eXtreme Adaptive optics (XAO), non-common path aberration compensation, coronagraphy, and science image post-processing. None of these steps alone is sufficient to leap the enormous contrast. High-contrast imaging (HCI) from the ground encompasses all those disciplines which are to be considered in a system approach. The presentation will introduce the principle of HCI and present the current implementation in the SPHERE, ESO's imager for giant exoplanets at the VLT. It will then discuss requirements and necessary R&D to reach the ultimate goal, observing terrestrial Exoplanets with the next generation of instruments for the ELTs.

  4. Improvement of phase diversity algorithm for non-common path calibration in extreme AO context

    Science.gov (United States)

    Robert, Clélia; Fusco, Thierry; Sauvage, Jean-François; Mugnier, Laurent

    2008-07-01

    Exoplanet direct imaging with a ground-based telescope needs a very high performance adaptive optics (AO) system, so-called eXtreme AO (XAO), a coronagraph device, and a smart imaging process. One limitation of AO system in operation remains the Non Common Path Aberrations (NCPA). To achieve the ultimate XAO performance, these aberrations have to be measured with a dedicated wavefront sensor placed in the imaging camera focal plane, and then pre-compensated using the AO closed loop process. In any events, the pre-compensation should minimize the aberrations at the coronagraph focal plane mask. An efficient way for the NCPA measurement is the phase diversity technique. A pixel-wise approach is well-suited to estimate NCPA on large pupils and subsequent projection on the deformable mirror with Cartesian geometry. However it calls for a careful regularization for optimal results. The weight of the regularization is written in close-form for un-supervised tuning. The accuracy of NCPA pre-compensation is below 8 nm for a wide range of conditions. Point-by-point phase estimation improves the accuracy of the Phase Diversity method. The algorithm is validated in simulation and experimentally. It will be implemented in SAXO, the XAO system of the second generation VLT instrument: SPHERE.

  5. Variability In Long-Wave Runup as a Function of Nearshore Bathymetric Features

    Energy Technology Data Exchange (ETDEWEB)

    Dunkin, Lauren McNeill [Texas A & M Univ., College Station, TX (United States)

    2010-05-01

    Beaches and barrier islands are vulnerable to extreme storm events, such as hurricanes, that can cause severe erosion and overwash to the system. Having dunes and a wide beach in front of coastal infrastructure can provide protection during a storm, but the influence that nearshore bathymetric features have in protecting the beach and barrier island system is not completely understood. The spatial variation in nearshore features, such as sand bars and beach cusps, can alter nearshore hydrodynamics, including wave setup and runup. The influence of bathymetric features on long-wave runup can be used in evaluating the vulnerability of coastal regions to erosion and dune overtopping, evaluating the changing morphology, and implementing plans to protect infrastructure. In this thesis, long-wave runup variation due to changing bathymetric features as determined with the numerical model XBeach is quantified (eXtreme Beach behavior model). Wave heights are analyzed to determine the energy through the surfzone. XBeach assumes that coastal erosion at the land-sea interface is dominated by bound long-wave processes. Several hydrodynamic conditions are used to force the numerical model. The XBeach simulation results suggest that bathymetric irregularity induces significant changes in the extreme long-wave runup at the beach and the energy indicator through the surfzone.

  6. The XWS open access catalogue of extreme European windstorms from 1979–2012

    Directory of Open Access Journals (Sweden)

    J. F. Roberts

    2014-03-01

    Full Text Available The XWS (eXtreme WindStorms catalogue consists of storm tracks and model-generated maximum three-second wind-gust footprints for 50 of the most extreme winter windstorms to hit Europe over 1979–2012. The catalogue is intended to be a valuable resource for both academia and industries such as (reinsurance, for example allowing users to characterise extreme European storms, and validate climate and catastrophe models. Several storm severity indices were investigated to find which could best represent a list of known high loss (severe storms. The best performing index was Sft, which is a combination of storm area calculated from the storm footprint and maximum 925 hPa wind speed from the storm track. All the listed severe storms are included in the catalogue, and the remaining ones were selected using Sft. A comparison of the model footprint to station observations revealed that storms were generally well represented, although for some storms the highest gusts were underestimated due to the model not simulating strong enough pressure gradients. A new recalibration method was developed to estimate the true distribution of gusts at each grid point and correct for this underestimation. The recalibration model allows for storm-to-storm variation which is essential given that different storms have different degrees of model bias. The catalogue is available at http:///www.europeanwindstorms.org/.

  7. Propagation of a short-pulse laser-driven electron beam in matter

    International Nuclear Information System (INIS)

    We studied the transport of an intense electron beam produced by high intensity laser pulses through metals and insulators. Targets were irradiated at two different intensities, 1017 W/cm2 and 1019 W/cm2, at the laser facility Xtreme Light XL-III in Beijing, a Ti:Sa laser source emitting 40 fs pulses at 800 nm. The main diagnostic was Cu-Kα fluorescence imaging. Images of Kα spots have been collected for those two laser intensities, for different target thickness, and for different materials. Experimental results are analyzed taking into account both collisional and collective effects as well as refluxing at the edge of the target. The target temperature is evaluated to be Tc ∼ 6 eV for intensity I = 1017 W/cm2 (for all the tested materials: plastic, aluminium, and copper), and Tc ∼ 60 eV in aluminium and 120 eV in titanium for intensity I = 1019 W/cm2.

  8. Adoption of Pair Programming in the Academic Environment with Different Degree of Complexity in Students Perspective– An Empirical Study

    Directory of Open Access Journals (Sweden)

    V.Venkatesan,

    2010-09-01

    Full Text Available Agile software development is a light weight process which is a solution for the heavy weight processes. EXtreme Programming is one of the Agile Methods. Pair Programming is one of best practice of eXtreme Programming. . It is a technique which concentrates not only on the software but also the developer who working on the software. Pair Programming is best suitable to produce efficient software. It accentuates the practice of two persons working together at a single computer terminal, to design, code and test computer programs. We studied the effects of pair programming in student context on knowledge transfer and enjoyment of work. We analyzed whether the taskcomplexity affects the effort differences between solo and pair programming. We conducted experiment to evaluate the efficiency of the knowledge transfer of the students when they adopt pair programming. The feedback from the student show the positive result that pair programming improves knowledge transfer and enjoyment of work. Through the experiment we also analyzed whether there is dependency between the task complexity and students capability. The result of this experiment shows that there is significant difference in the duration of task completion, the effort to perform the task correctly between solo and pair programming.

  9. Teorizando as Práticas dos Métodos Ágeis no Desenvolvimento de Software Visando ao Processo de Inovação das Empresas

    Directory of Open Access Journals (Sweden)

    Dolci, Décio Bittencourt

    2011-11-01

    Full Text Available Brazilian IT executives are being challenged to play an active and important role in the innovation process within their organizations. The purpose of this study is to explore agile software development methods in facing this challenge. We deployed a practice theory framework, in particular that of Orlikowski, in order to analyze practices from seven agile methods – eXtreme Programming (XP, Dynamic Systems Development Method (DSDM, Scrum, Crystal, Agile Modeling (AM, Feature Driven Design (FDD and Adaptive Software Development (ASD. Results show practices grouped into five underlying factors – learning, iteractive, customer, human and technical; in addition, they explain the shift in focus of the agile development in reference to previous methods, centering on the individual and their actions in social relations in place of essentially technical issues. Findings suggest that agile software development methods have principles and practices better suitable to the innovation challenge than their predecessors do. Furthermore, their practices can aid the organization in the constitution of institutional properties useful to the process of business model innovation.

  10. Software Development Process Improvement Framework (SDPIF for Small Software Development Firms (SSDFs

    Directory of Open Access Journals (Sweden)

    Mejhem Yousef

    2013-01-01

    Full Text Available Most of the software development organizations all over the world are Small Software Development Firms (SSDFs. These firms have realized that it is necessary to organize and improve their software development and management activities. Traditional software process improvement (SPI models and standards are generally not possible to be implemented directly by SSDFs, as these firms are not capable of investing the cost of implementing these programs due to limited resources and strict deadlines to complete the projects. In addition, the existing regional SPI models which were developed for SSDFs are not suitable to be implemented by SSDFs all over the world. Furthermore, SSDFs also have ignored the software development practices to explain: how to do the improvement; as they only focus on: what to do for improvement. This paper presents a new software development process improvement framework (SDPIF for SSDFs based on eXtreme programming (XP as the software development method and Capability Maturity Model Integration version 1.2 for Development (CMMI-Dev1.2 as the SPI model.

  11. The Effects of Pair Programming on Learning Efficiency in Short Programming Assignments

    Directory of Open Access Journals (Sweden)

    Subbaraya KUPPUSWAMI

    2004-10-01

    Full Text Available Pair programming is one of the important practices of a lightweight development methodology namely eXtreme Programming (XP. It emphasizes the practice of two persons working together at a single computer terminal, to design, code and test computer programs. The effects of pair programming on software development in industrial organizations were studied and it was found that pair programming increases the productivity by 15%. This evidence created an interest in amongst community of computer science educators to apply pair programming in educational settings. We have conducted an experiment with the students of computer science courses to compare the learning efficiency of students when they adopt pair programming with that of students using traditional method to do laboratory exercises of short duration. The learning efficiency was measured by evaluating design documents, completion time, and marks obtained in a written test that was conducted after every exercise. Our research confirms that the adoption of pair programming improves the design ability, reduces time taken to do a laboratory exercise and increases the knowledge and programming skill.

  12. INVESTIGATION OF STUDENT’S PERSONALITY ON PAIR PROGRAMMING TO ENHANCE THE LEARNING ACTIVITY IN THE ACADEMIA

    Directory of Open Access Journals (Sweden)

    V. Venkatesan

    2014-01-01

    Full Text Available Agile Software development is now a global phenomenon and is rapidly becoming organizations’ most preferred IT process. Extreme Programming (XP is one of the Agile Methods and Collaborative Pair Programming (CPP is one of the very important practices of eXtreme Programming. Agile focuses team work which is very important in the field of software development. The software industry has practiced CPP, where two programmers working side by side on one computer on the same problem with great success. Similar experiments have been conducted in academia and pair programming has been shown to be beneficial for both students and teaching staff in university courses. In this study, we conducted some set of experiments about the “human” aspect of the CPP; in particular the effects that personality attributes may have on pair programmer’s effectiveness as a pedagogical tool. A formal experiment has been conducted during 2012-13 odd semester at the PSG College of Technology, India to investigate the influence of personality differences among paired students using the five-factor model as a personality measurement framework. The aim of this research is to improve the implementation of CPP as a pedagogical tool to the academic setup through understanding the impact of the variation in the personality profile of paired students towards their academic performance.

  13. SILEX-I 330-TW, 30-fs Ti:sapphire laser system

    Energy Technology Data Exchange (ETDEWEB)

    Xiaofeng, W; Xiaojun, H; Hansheng, P; Xiaodong, W; Xiaomin, Z; Kainan, Z; Lanqin, G Y L; Xiao, W; Qihua, Z; Donghui, L [Research Center of Laser Fusion, China Academy of Engineering Physics, P. O. Box 919-988, Mianyang, Sichuan, 621900 (China)], E-mail: xfwei@caep.ac.cn

    2008-05-15

    The evolution of Ti:Sapphire laser system named SILEX-I(Super Intense Laser for Experiments on eXtreme) with the peak power of 330 TW is presented [2]. SILEX-I includes the femtosecond oscillator, the Offner stretcher, the regenerative amplifier, the pre-amplifier, the main amplifier, the power amplifier, the vacuum compressor and the vacuum target chamber. SILEX-I has three order output power: 6 TW, 30 TW, and hundreds of terawatt. And there are corresponding target chamber at the different power output for the different physical experiments. Some technology are added to the laser system to decrease the deleterious effects such as gain narrowing, gain shifting, high order dispersion.{center_dot}Now the peak power with 330 TW is obtained, and the pulse width with 29.8 fs after the compressor. The focal intensity is near 1x10{sup 21}W/cm{sup 2} with the focal spot of 5.7 {mu}m.

  14. Avances en las Mejoras de Procesos Software en las MiPyMEs Desarrolladoras de Software: Una Revisión Sistemática

    Directory of Open Access Journals (Sweden)

    Gerzon E. Gómez

    2014-08-01

    Full Text Available Este trabajo presenta la aplicación de un protocolo para revisiones sistemáticas de Ingeniería de Software. En este artículo el protocolo es utilizado como un modelo formal aplicado a la búsqueda de publicaciones relacionadas con las adaptaciones SPI llevadas a cabo en MiPyMEs desarrolladoras de software, en el período comprendido de 1995 a diciembre de 2013, centrán- dose en tendencias, países, y sectores que publican, así como en los modelos, metodologías, estándares y procesos de soporte del software del área de calidad. Los resultados obtenidos sugieren que en la comunidad de Ingeniería de Software hay un interés creciente en este tema, por ejemplo, la mayoría de las inves-tigaciones realizadas surgen en el sector educativo. El modelo de procesos y la metodología más utilizada es CMMi y Xtreme Pro-graming, respectivamente. El estándar más utilizado es el ISO/ IEC 15504 y el proceso de soporte del software del ciclo de vida del software mayormente abordado es SQA.

  15. Atomic delay in helium, neon, argon and krypton

    International Nuclear Information System (INIS)

    Photoionization by an eXtreme UltraViolet (XUV) attosecond pulse train (APT) in the presence of an infrared pulse (RABBITT method) conveys information about the atomic photoionization delay. By taking the difference of the spectral delays between pairs of rare gases (Ar,He), (Kr,He) and (Ne,He) it is possible to eliminate in each case the larger group delay (‘attochirp’) associated with the APT itself and obtain the Ar, Kr and Ne Wigner delays referenced to model calculations of the He delay. In this work we measure how the delays vary as a function of XUV photon energy but we cannot determine the absolute delay difference between atoms due to lack of precise knowledge of the initial conditions. The extracted delays are compared with several theoretical predictions and the results are consistent within 30 as over the energy range from 10 to 50 eV. An ‘effective’ Wigner delay over all emission angles is found to be more consistent with our angle-integrated measurement near the Cooper minimum in Ar. We observe a few irregular features in the delay that may be signatures of resonances. (paper)

  16. Improved removal of sticky and light contaminants from wastepaper. Final report, April 1, 1995--December 31, 1997

    Energy Technology Data Exchange (ETDEWEB)

    Seifert, P.; Kelly, A.

    1998-03-01

    Work under this two-year cooperative agreement addresses improved removal of light and sticky contaminants from waste paper. Such contaminants occur in ever-increasing amounts, resulting from glues, labels, book bindings, packaging tapes, etc., all associated with the waste paper stream. Despite various cleaning steps in the paper mill recycling systems, residual contamination remains, causing big problems with the product quality and with paper machine and converting operations. Some grades cannot be recycled at all. Stickies are truly a barrier against increased paper recycling. The stickies problem was attacked in four project segments--three of those have yielded tangible results. One segment has been outstanding in its success; namely, the development of a centrifugal reverse cleaning system consisting of primary and secondary stages, which have unparalleled high efficiency in the removal of light and sticky contaminants. This cleaning system, consists of primary XTREME and secondary XX-Clone units. Another segment of this work, washing wax contaminated old corrugated wastepaper (OCC), also has resulted in the new Xtrax process which was released for sale.

  17. Post-merger analytic templates for GW150914

    CERN Document Server

    Nagar, Alessandro

    2016-01-01

    Following the new analytic description of the postmerger (ringdown) waveform of coalescing, nonprecessing, spinning, black hole binaries (BBHs) introduced in Phys.~Rev.~D~90, 024054 (2014), we propose an analytic, closed form, time-domain, representation of the $\\ell=m=2$ gravitational radiation mode emitted after merger. This expression is given as a function of the masses and dimensionless spins $(m_{1,2},\\chi_{1,2})$ of the two inspiralling objects, as well as of the mass $M_{\\rm BH}$ and (complex) frequency $\\sigma_{1}$ of the fundamental quasi-normal mode of the final black hole. It is obtained by first fitting the postmerger waveform part of several numerical relativity simulations of the Simulating eXtreme Spacetimes (SXS) catalog and then suitably interpolating over (symmetric) mass ratio and spins. It is demonstrated that this analytic expression reproduces rather accurately the post-merger waveform of other SXS datasets not used to build it and, notably, the dataset SXS:BBH:0305, corresponding to a ...

  18. BCM57710:10GbE聚合网络界面控制器

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ Broadcom日前推出单芯片双端口10GbE聚合网络界面控制器(C-NIC)--BCM57710,以迎合大批量服务器的设计.基于之前两代成熟的NetXtreme II千兆以太网C-NIC技术,Broodcom此次成功发布业界首款10Gbps(千兆比特/每秒)速率的全功能、单芯片聚合网络界面控制器(C-NIC),这款产品不需要外部缓存的支持.BCM57710丰富及完善了Broadcom以其市场领先的C-NIC、企业路由器和物理层设备为主的10GbE端到端解决方案的业务组合,使其OEM合作伙伴能够借助其提供的完整的10GbE网络架构解决方案增强下一代服务器的性能.

  19. Scientific data analysis on data-parallel platforms.

    Energy Technology Data Exchange (ETDEWEB)

    Ulmer, Craig D.; Bayer, Gregory W.; Choe, Yung Ryn; Roe, Diana C.

    2010-09-01

    As scientific computing users migrate to petaflop platforms that promise to generate multi-terabyte datasets, there is a growing need in the community to be able to embed sophisticated analysis algorithms in the computing platforms' storage systems. Data Warehouse Appliances (DWAs) are attractive for this work, due to their ability to store and process massive datasets efficiently. While DWAs have been utilized effectively in data-mining and informatics applications, they remain largely unproven in scientific workloads. In this paper we present our experiences in adapting two mesh analysis algorithms to function on five different DWA architectures: two Netezza database appliances, an XtremeData dbX database, a LexisNexis DAS, and multiple Hadoop MapReduce clusters. The main contribution of this work is insight into the differences between these DWAs from a user's perspective. In addition, we present performance measurements for ten DWA systems to help understand the impact of different architectural trade-offs in these systems.

  20. Meteoric fluids in the South Tibetan Detachment and palaeoaltimetry of Central Himalaya

    Science.gov (United States)

    Gébelin, Aude; Mulch, Andreas; Teyssier, Christian; Jessup, Micah J.; Brunel, Maurice; Cosca, Michael A.; Law, Rick D.

    2015-04-01

    The South Tibetan Detachment (STD) is one of the most fundamental structures within the Himalayan orogenic belt. It exposes a mylonite zone over a distance of > 1500 km along strike that is hundreds of metres thick and separates Paleozoic sedimentary units from high-grade metamorphic rocks and syntectonic leucogranites. In this study, we document the infiltration of meteoric fluids in the STD footwall at ~15 Ma when recrystallized hydrous minerals equilibrated with evolved meteoric water and therefore recorded the hydrogen isotope composition of water present during mylonitic deformation. Although these minerals deformed and recrystallized at significant depth (~10 km), they can be used as palaeoelevation proxies if they can be temporally and kinematically linked to the evolution of the STD. Stable isotope palaeoaltimetry uses the systematic relationship between the oxygen (d18O) and hydrogen (dD) isotope ratios of rainfall that scale with elevation in a predictable fashion (~2.8 per mil in d18O or ~22 per mil in dD per km). Here, we present palaeoaltimetry estimates based on the hydrogen isotope composition of synkinematic micas and amphiboles collected over 200 m of structural section from the STD into the underlying mylonitic footwall at Rongbuk Valley (Mount Everest region). Biotites reveal a very constant pattern of mid-Miocene 40Ar/39Ar plateau ages and exchanged isotopically at high temperature with D-depleted water (dDwater ~ -150 ±5 per mil) that originated from high-elevation precipitation and infiltrated the crustal hydrologic system at that time. To eliminate a climate impact on our palaeoelevation estimates, the hydrogen isotope record from the high elevation STD is compared to time-equivalent low-elevation foreland d18O records. Our palaeoaltimetry results indicate that the mean elevation of Mount Everest region during the mid-Miocene was similar to today (~5200 m). This has two main implications: (1) Strengthening of the Asian Summer Monsoon may

  1. Seasonal and annual mass balances of Mera and Pokalde glaciers (Nepal Himalaya since 2007

    Directory of Open Access Journals (Sweden)

    P. Wagnon

    2013-07-01

    Full Text Available In the Everest region, Nepal, ground-based monitoring programs were started on the debris-free Mera Glacier (27.7° N, 86.9° E; 5.1 km2, 6420 to 4940 m a.s.l. in 2007 and on the small Pokalde Glacier (27.9° N, 86.8° E; 0.1 km2, 5690 to 5430 m a.s.l., ∼ 25 km North of Mera Glacier in 2009. These glaciers lie on the southern flank of the central Himalaya under the direct influence of the Indian monsoon and receive more than 80% of their annual precipitation in summer (June to September. Despite a large inter-annual variability with glacier-wide mass balances ranging from −0.77± 0.40 m w.e. in 2011–2012 (Equilibrium-line altitude (ELA at ∼ 6055 m a.s.l. to + 0.46 ± 0.40 m w.e. in 2010–2011 (ELA at ∼ 5340 m a.s.l., Mera Glacier has been shrinking at a moderate mass balance rate of −0.10± 0.40 m w.e. yr−1 since 2007. Ice fluxes measured at two distinct transverse cross sections at ∼ 5350 m a.s.l. and ∼ 5520 m a.s.l. confirm that the mean state of this glacier over the last one or two decades corresponds to a limited mass loss, in agreement with remotely-sensed region-wide mass balances of the Everest area. Seasonal mass balance measurements show that ablation and accumulation are concomitant in summer which in turn is the key season controlling the annual glacier-wide mass balance. Unexpectedly, ablation occurs at all elevations in winter due to wind erosion and sublimation, with remobilized snow likely being sublimated in the atmosphere. Between 2009 and 2012, the small Pokalde Glacier lost mass more rapidly than Mera Glacier with respective mean glacier-wide mass balances of −0.72 and −0.26 ± 0.40 m w.e. yr−1. Low-elevation glaciers, such as Pokalde Glacier, have been usually preferred for in-situ observations in Nepal and more generally in the Himalayas, which may explain why compilations of ground-based mass balances are biased toward negative values compared with the regional mean under the present-day climate.

  2. THE ESTABLISHMENT OF THE PHYSIOLOGICAL BASED PHARMACOKINETIC MODEL FOR QUINOCETONE IN GRASS CARP (CTENOPHARYNGODON IDELLUS)%喹烯酮在草鱼体内生理药动模型的建立

    Institute of Scientific and Technical Information of China (English)

    胥宁; 刘永涛; 杨秋红; 艾晓辉

    2015-01-01

    为了预测喹烯酮在草鱼体内药物残留, 建立其在草鱼体内生理药动学模型.通过搜集大量文献获得鱼的生理解剖参数, 采用已有的喹烯酮试验数据拟合得到药物特异性参数.基于 acslXtreme 生理药动学软件,进行模型假设、血流图设计、质量平衡方程的建立和模型拟合.喹烯酮为小分子药物, 其分布服从血流限速型, 在肝脏代谢, 从肾脏消除.喹烯酮通过口服进入肠道, 然后经肝脏代谢进入血液循环, 因此设定 5 个房室, 即肝、肾、肌肉、肠和其他组织.经过一系列的计算和调试, 最终建立喹烯酮在草体内5室生理药动模型, 成功拟合连续饲喂药物 60d之后的药物残留消除曲线, 其中肝脏中的预测结果比肾脏和肌肉高, 与实测数据一致.因此, 喹烯酮在鱼体内生理药动模型具有一定的应用价值, 将是药物残留检测的新亮点.%An effective physiological-based pharmacokinetic (PB-PK) model can be used to analogize and extrapolate the in vivo drug concentrations in different administrations and environments, as well as in different species of animals, hence it has become more and more popular in the drug residual prediction in aquatic animals. In order to predict drug residues of quinocetone in grass carp (Ctenopharyngodon idellus), we established the PB-PK model of quinocetone in this study. We obtained the physiological and anatomical parameters of fish from literatures, and estimated the drug-specific parameters of quinocetone by fitting the existing data. We used the physiological pharmacokinetic soft-ware, asclXtreme, to make the model assumptions, to design the blood flow chart, to generate the mass balance equa-tions and to complete the model fitting. Quinocetone was a small molecule drug, and itsin vivo disposition was blood flow-limited. It was metabolized by the liver and excreted by the kidney. Quinocetone entered the intestine through oral administration and

  3. Engineering Annual Summary 1998

    Energy Technology Data Exchange (ETDEWEB)

    Dimolitsas, S

    1999-05-01

    Unlike most research and development laboratories, Lawrence Livermore National Laboratory (LLNL) is responsible for delivering production-ready designs. Unlike most industry, LLNL is responsible for R and D that must significantly increase the nation's security. This rare combination of production engineering expertise and national R and D agenda identifies LLNL as one of the few organizations today that conducts cutting-edge engineering on grand-scale problems, while facing enormous technical risk and undergoing diligent scrutiny of its budget, schedule, and performance. On the grand scale, cutting-edge technologies are emerging from our recent ventures into ''Xtreme Engineering{trademark}.'' Basically, we must integrate and extend technologies concurrently and then push them to their extreme, such as building very large structures but aligning them with extreme precision. As we extend these technologies, we push the boundaries of engineering capabilities at both poles: microscale and ultrascale. Today, in the ultrascale realm, we are building NIF, the world's largest laser, which demands one of the world's most complex operating systems with 9000 motors integrated through over 500 computers to control 60,000 points for every laser shot. On the other pole, we have fabricated the world's smallest surgical tools and the smallest instruments for detecting biological and chemical agents used by antiterrorists. Later in this Annual Summary, we highlight some of our recent innovations in the area of Xtreme Engineering, including large-scale computer simulations of massive structures such as major bridges to prepare retrofitting designs to withstand earthquakes. Another feature is our conceptual breakthrough in developing the world's fastest airplane, HyperSoar, which can reach anywhere in the planet in two hours at speeds of 6700 mph. In the last few years, Engineering has significantly pushed the technology in structural

  4. Recent change of the ice core accumulation rates on the Qinghai-Tibetan Plateau

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Three ice cores recovered from the Himalayas (i.e. the East Rongbuk Glacier and the Far East Rongbuk Glacier at Mt. Qomolangma (Everest), and the Dasuopu Glacier at Xixiabangma) show a sharp decline in the accumulation rates since the 1950s, which is consistent with the precipitation fluctuation over India and the low northern latitude zone (5°-35°N). Correspondingly, an increasing trend is observed for the ice core accumulations from the central and northern Qingh ai-Tibetan Plateau (i.e. the Xiao Dongkemadi Glacier in the central Tanggula Mountains, the Guliya Ice Cap in the western Kunlun Mountains, and the Dunde Ice Cap in the Qilian Mountains) since the 1950s, which is consistent with the precipi tation fluctuation over the middle-high northern latitude zone (35°-70°N). However, the variation magnitude of the high-elevation ice core accumulations is more significant than that of precipitation at the low-eleva- tion places, suggesti ng its extra sensitivity of high-elevation areas to climatic change. The inter-d ecadal abrupt change of the African-Asian summer monsoon in the1960s may attribute to the recent ice core accumulation change during the recent decades.

  5. Marginal accuracy of four-unit zirconia fixed dental prostheses fabricated using different computer-aided design/computer-aided manufacturing systems.

    Science.gov (United States)

    Kohorst, Philipp; Brinkmann, Henrike; Li, Jiang; Borchers, Lothar; Stiesch, Meike

    2009-06-01

    Besides load-bearing capacity, marginal accuracy is a further crucial factor influencing the clinical long-term reliability of fixed dental prostheses (FDPs). The aim of this in vitro study was to evaluate the marginal fit of four-unit zirconia bridge frameworks fabricated using four different computer-aided design (CAD)/computer-aided manufacturing (CAM) systems. Ten frameworks were manufactured using each fabricating system. Three systems (inLab, Everest, Cercon) processed white-stage zirconia blanks, which had to be sintered to final density after milling, while with one system (Digident) restorations were directly milled from a fully sintered material. After manufacturing, horizontal and vertical marginal discrepancies, as well as the absolute marginal discrepancy, were determined by means of a replica technique. The absolute marginal discrepancy, which is considered to be the most suitable parameter reflecting restorations' misfit in the marginal area, had a mean value of 58 mum for the Digident system. By contrast, mean absolute marginal discrepancies for the three other systems, processing presintered blanks, differed significantly and ranged between 183 and 206 mum. Within the limitations of this study, it could be concluded that the marginal fit of zirconia FDPs is significantly dependent on the CAD/CAM system used, with restorations processed of fully sintered zirconia showing better fitting accuracy. PMID:19583762

  6. Glacier melting and precipitation trends detected by surface area changes in Himalayan ponds

    Science.gov (United States)

    Salerno, Franco; Thakuri, Sudeep; Guyennon, Nicolas; Viviano, Gaetano; Tartari, Gianni

    2016-07-01

    Climatic time series for high-elevation Himalayan regions are decidedly scarce. Although glacier shrinkage is now sufficiently well described, the changes in precipitation and temperature at these elevations are less clear. This contribution shows that the surface area variations of unconnected glacial ponds, i.e. ponds not directly connected to glacier ice, but that may have a glacier located in their hydrological basin, can be considered as suitable proxies for detecting past changes in the main hydrological components of the water balance. On the south side of Mt Everest, glacier melt and precipitation have been found to be the main drivers of unconnected pond surface area changes (detected mainly with Landsat imagery). In general, unconnected ponds have decreased significantly by approximately 10 ± 5 % in terms of surface area over the last 50 years (1963-2013 period) in the study region. Here, an increase in precipitation occurred until the mid-1990s followed by a decrease until recent years. Until the 1990s, glacier melt was constant. An increase occurred in the early 2000s, while a declining trend in maximum temperature has caused a reduction in the glacier melt during recent years.

  7. Widespread ground motion distribution caused by rupture directivity during the 2015 Gorkha, Nepal earthquake.

    Science.gov (United States)

    Koketsu, Kazuki; Miyake, Hiroe; Guo, Yujia; Kobayashi, Hiroaki; Masuda, Tetsu; Davuluri, Srinagesh; Bhattarai, Mukunda; Adhikari, Lok Bijaya; Sapkota, Soma Nath

    2016-06-23

    The ground motion and damage caused by the 2015 Gorkha, Nepal earthquake can be characterized by their widespread distributions to the east. Evidence from strong ground motions, regional acceleration duration, and teleseismic waveforms indicate that rupture directivity contributed significantly to these distributions. This phenomenon has been thought to occur only if a strike-slip or dip-slip rupture propagates to a site in the along-strike or updip direction, respectively. However, even though the earthquake was a dip-slip faulting event and its source fault strike was nearly eastward, evidence for rupture directivity is found in the eastward direction. Here, we explore the reasons for this apparent inconsistency by performing a joint source inversion of seismic and geodetic datasets, and conducting ground motion simulations. The results indicate that the earthquake occurred on the underthrusting Indian lithosphere, with a low dip angle, and that the fault rupture propagated in the along-strike direction at a velocity just slightly below the S-wave velocity. This low dip angle and fast rupture velocity produced rupture directivity in the along-strike direction, which caused widespread ground motion distribution and significant damage extending far eastwards, from central Nepal to Mount Everest.

  8. Widespread ground motion distribution caused by rupture directivity during the 2015 Gorkha, Nepal earthquake.

    Science.gov (United States)

    Koketsu, Kazuki; Miyake, Hiroe; Guo, Yujia; Kobayashi, Hiroaki; Masuda, Tetsu; Davuluri, Srinagesh; Bhattarai, Mukunda; Adhikari, Lok Bijaya; Sapkota, Soma Nath

    2016-01-01

    The ground motion and damage caused by the 2015 Gorkha, Nepal earthquake can be characterized by their widespread distributions to the east. Evidence from strong ground motions, regional acceleration duration, and teleseismic waveforms indicate that rupture directivity contributed significantly to these distributions. This phenomenon has been thought to occur only if a strike-slip or dip-slip rupture propagates to a site in the along-strike or updip direction, respectively. However, even though the earthquake was a dip-slip faulting event and its source fault strike was nearly eastward, evidence for rupture directivity is found in the eastward direction. Here, we explore the reasons for this apparent inconsistency by performing a joint source inversion of seismic and geodetic datasets, and conducting ground motion simulations. The results indicate that the earthquake occurred on the underthrusting Indian lithosphere, with a low dip angle, and that the fault rupture propagated in the along-strike direction at a velocity just slightly below the S-wave velocity. This low dip angle and fast rupture velocity produced rupture directivity in the along-strike direction, which caused widespread ground motion distribution and significant damage extending far eastwards, from central Nepal to Mount Everest. PMID:27335317

  9. Computational modelling of semiconducting X-ray detectors

    CERN Document Server

    Fowler, R F; Greenough, C S

    2002-01-01

    The design of high-performance semiconductor detectors is dominated by requirements on position and energy resolution and speed of operation. We investigate the contribution that three-dimensional transient device modelling can make to understanding these and the potential for its use in the design cycle. Simulations are performed using the EVEREST software to solve the drift-diffusion equations. Extra functionality has been added to allow the generation of electron-hole pairs by, for example, the absorption of an X-ray. Careful time integration can measure the time of arrival of the charge packet at the collecting well. By time integrating the current arriving in the collecting well the spatial distribution of charge can be determined. A simple analytic theory is developed and compared with simulations of a large pixel detector. Comparisons with simulations of a two pixel device show that the analytic approximation is reasonable if the X-ray is absorbed beyond 100 mu m from the well, but events closer show a...

  10. CLOUD COMPUTING TECHNOLOGY TRENDS

    Directory of Open Access Journals (Sweden)

    Cristian IVANUS

    2014-05-01

    Full Text Available Cloud computing has been a tremendous innovation, through which applications became available online, accessible through an Internet connection and using any computing device (computer, smartphone or tablet. According to one of the most recent studies conducted in 2012 by Everest Group and Cloud Connect, 57% of companies said they already use SaaS application (Software as a Service, and 38% reported using standard tools PaaS (Platform as a Service. However, in the most cases, the users of these solutions highlighted the fact that one of the main obstacles in the development of this technology is the fact that, in cloud, the application is not available without an Internet connection. The new challenge of the cloud system has become now the offline, specifically accessing SaaS applications without being connected to the Internet. This topic is directly related to user productivity within companies as productivity growth is one of the key promises of cloud computing system applications transformation. The aim of this paper is the presentation of some important aspects related to the offline cloud system and regulatory trends in the European Union (EU.

  11. Virtual reality simulation for the optimization of endovascular procedures: current perspectives

    Directory of Open Access Journals (Sweden)

    Rudarakanchana N

    2015-03-01

    Full Text Available Nung Rudarakanchana,1 Isabelle Van Herzeele,2 Liesbeth Desender,2 Nicholas JW Cheshire1 1Department of Surgery, Imperial College London, London, UK; 2Department of Thoracic and Vascular Surgery, Ghent University Hospital, Ghent, BelgiumOn behalf of EVEREST (European Virtual reality Endovascular RESearch TeamAbstract: Endovascular technologies are rapidly evolving, often requiring coordination and cooperation between clinicians and technicians from diverse specialties. These multidisciplinary interactions lead to challenges that are reflected in the high rate of errors occurring during endovascular procedures. Endovascular virtual reality (VR simulation has evolved from simple benchtop devices to full physic simulators with advanced haptics and dynamic imaging and physiological controls. The latest developments in this field include the use of fully immersive simulated hybrid angiosuites to train whole endovascular teams in crisis resource management and novel technologies that enable practitioners to build VR simulations based on patient-specific anatomy. As our understanding of the skills, both technical and nontechnical, required for optimal endovascular performance improves, the requisite tools for objective assessment of these skills are being developed and will further enable the use of VR simulation in the training and assessment of endovascular interventionalists and their entire teams. Simulation training that allows deliberate practice without danger to patients may be key to bridging the gap between new endovascular technology and improved patient outcomes.Keywords: virtual reality, simulation, endovascular, aneurysm

  12. Anthropometric and body composition changes during expeditions at high altitude.

    Science.gov (United States)

    Zaccagni, Luciana; Barbieri, Davide; Cogo, Annalisa; Gualdi-Russo, Emanuela

    2014-06-01

    The purpose of this study is to investigate separately in the two sexes the physical adaptations associated to exposure to high altitude in a sample of 18 nonacclimatized Caucasian subjects (10 males and 8 females, 22-59 years) who participated to scientific expeditions to Himalaya up to the Pyramid Laboratory (5050 m, Nepal) or Everest North Base Camp (5300 m, Tibet). Anthropometric traits (body height and weight, eight girths and six skinfolds) were collected according to standard procedures, before departure at sea level, during ascent (at altitude > 4000 m above sea level), and after return to low altitude. Body composition was assessed by means of the skinfold method. Both sexes lost on average 4.0% of initial body mass, corresponding to 7.6% of fat mass and 3.5% of fat free mass in males, and to 5.0% of fat mass and 3.6% of fat free mass in females. Average fat mass loss was greater in males than in females. Initial fat mass percentage was positively correlated to fat mass loss and negatively to FFM loss in males only, thus at HA leanest subjects lost more FFM and less FM than the fattest ones. Adaptations were faster in males than in females. In conclusion, the present research describes significant adaptations to high altitude, in terms of body weight reduction, regardless of the amount of performed physical activity. PMID:24665979

  13. Multiple Carrying Capacities from a management-oriented perspective to operationalize sustainable tourism in protected areas.

    Science.gov (United States)

    Salerno, Franco; Viviano, Gaetano; Manfredi, Emanuela C; Caroli, Paolo; Thakuri, Sudeep; Tartari, Gianni

    2013-10-15

    This article describes how the concept of Tourism Carrying Capacity (TCC) has shifted from a uni-dimensional approach to incorporating environmental, social and political aspects. This shift is demonstrated by a study of a large, internationally popular protected area used by trekkers, the Mt. Everest Region, where qualitative data collected from visitors was combined with environmental modeling using a participatory framework. Tourist satisfaction showed positive margins for further tourist industry expansion, but current environmental conditions limit growth and further development. Space and time dimensions were also considered. We observed that the limits on growth and further development can be manipulated, with a certain degree of flexibility, through investments and regulatory measures. We hypothesized that TCC can play an important role in the management of protected areas only if it is viewed as a systematic, strategic policy tool within a planning process rather than as a unique, intrinsic number that is not modifiable. We conclude that to translate the strategy into action using standard measures, further investigation is needed to balance the various TCC components as a part of a decision-making framework that includes the integration of different cultural approaches and policy needs.

  14. Multiple Carrying Capacities from a management-oriented perspective to operationalize sustainable tourism in protected areas.

    Science.gov (United States)

    Salerno, Franco; Viviano, Gaetano; Manfredi, Emanuela C; Caroli, Paolo; Thakuri, Sudeep; Tartari, Gianni

    2013-10-15

    This article describes how the concept of Tourism Carrying Capacity (TCC) has shifted from a uni-dimensional approach to incorporating environmental, social and political aspects. This shift is demonstrated by a study of a large, internationally popular protected area used by trekkers, the Mt. Everest Region, where qualitative data collected from visitors was combined with environmental modeling using a participatory framework. Tourist satisfaction showed positive margins for further tourist industry expansion, but current environmental conditions limit growth and further development. Space and time dimensions were also considered. We observed that the limits on growth and further development can be manipulated, with a certain degree of flexibility, through investments and regulatory measures. We hypothesized that TCC can play an important role in the management of protected areas only if it is viewed as a systematic, strategic policy tool within a planning process rather than as a unique, intrinsic number that is not modifiable. We conclude that to translate the strategy into action using standard measures, further investigation is needed to balance the various TCC components as a part of a decision-making framework that includes the integration of different cultural approaches and policy needs. PMID:23728182

  15. Widespread ground motion distribution caused by rupture directivity during the 2015 Gorkha, Nepal earthquake

    Science.gov (United States)

    Koketsu, Kazuki; Miyake, Hiroe; Guo, Yujia; Kobayashi, Hiroaki; Masuda, Tetsu; Davuluri, Srinagesh; Bhattarai, Mukunda; Adhikari, Lok Bijaya; Sapkota, Soma Nath

    2016-01-01

    The ground motion and damage caused by the 2015 Gorkha, Nepal earthquake can be characterized by their widespread distributions to the east. Evidence from strong ground motions, regional acceleration duration, and teleseismic waveforms indicate that rupture directivity contributed significantly to these distributions. This phenomenon has been thought to occur only if a strike-slip or dip-slip rupture propagates to a site in the along-strike or updip direction, respectively. However, even though the earthquake was a dip-slip faulting event and its source fault strike was nearly eastward, evidence for rupture directivity is found in the eastward direction. Here, we explore the reasons for this apparent inconsistency by performing a joint source inversion of seismic and geodetic datasets, and conducting ground motion simulations. The results indicate that the earthquake occurred on the underthrusting Indian lithosphere, with a low dip angle, and that the fault rupture propagated in the along-strike direction at a velocity just slightly below the S-wave velocity. This low dip angle and fast rupture velocity produced rupture directivity in the along-strike direction, which caused widespread ground motion distribution and significant damage extending far eastwards, from central Nepal to Mount Everest. PMID:27335317

  16. Instance-oriented delegation: A solution for providing security to Grid-based mobile agent middleware

    Institute of Scientific and Technical Information of China (English)

    MA Tian-chi; LI Shan-ping

    2005-01-01

    New challenges are introduced when people try to build a general-purpose mobile agent middleware in Grid environment. In this paper, an instance-oriented security mechanism is proposed to deal with possible security threats in such mobile agent systems. The current security support in Grid Security Infrastructure (GSI) requires the users to delegate their privileges to certain hosts. This host-oriented solution is insecure and inflexible towards mobile agent applications because it cannot prevent delegation abuse and control well the diffusion of damage. Our proposed solution introduces security instance, which is an encapsulation of one set of authorizations and their validity specifications with respect to the agent's specific code segments, or even the states and requests. Applications can establish and configure their security framework flexibly on the same platform, through defining instances and operations according to their own logic. Mechanisms are provided to allow users delegating their identity to these instances instead of certain hosts. By adopting this instance-oriented security mechanism, a Grid-based general-purpose MA middleware, Everest, is developed to enhance Globus Toolkit's security support for mobile agent applications.

  17. Understanding land use, livelihoods, and health transitions among Tibetan nomads: a case from Gangga Township, Dingri County, Tibetan Autonomous Region of China.

    Science.gov (United States)

    Xu, Jianchu; Yang, Yong; Li, Zhuoqing; Tashi, Nyima; Sharma, Rita; Fang, Jing

    2008-06-01

    Tibetan nomads in the Tibetan Autonomous Region of China have experienced profound transitions in recent decades with important implications for land use, livelihoods, and health development. The change from being traditional nomads to agropastoralists engaged in permanent agriculture, a sedentary village life (known as "sedentarization"), has been associated with a remarkable change in diet and lifestyle, decline in spatial mobility, increase in food production, and emerging infectious and noncommunicable diseases. The overarching response of the government has been to emphasize infrastructure and technological solutions. The local adaptation strategies of Tibetan nomads through maintaining balanced mobile herding, reindeer husbandry, as well as off-farm labor and trade could address both the cause of environmental degradation and improve the well-being of local people. Drawing on transdisciplinary, preliminary field work in Gangga Township of Dingri County in the foothills of Mt. Everest, we identify pertinent linkages between land use and health, and spatial and temporal mismatch of livelihoods and health care services, in the transition to sedentary village life. We suggest emerging imperatives in Ecohealth to help restore Tibetan livelihoods in transition to a sedentary lifestyle.

  18. On-sky validation of an optimal LQG control with vibration mitigation: from the CANARY Multi-Object Adaptive Optics demonstrator to the Gemini Multi-Conjugated Adaptive Optics facility.

    Science.gov (United States)

    Sivo, Gaetano; Kulcsár, Caroline; Conan, Jean-Marc; Raynaud, Henri-François; Gendron, Éric; Basden, Alastair; Gratadour, Damien; Morris, Tim; Petit, Cyril; Meimon, Serge; Rousset, Gérard; Garrel, Vincent; Neichel, Benoit; van Dam, Marcos; Marin, Eduardo; Carrasco, Rodrigo; Schirmer, Mischa; Rambold, William; Moreno, Cristian; Montes, Vanessa; Hardie, Kayla; Trujillo, Chad

    2015-01-01

    Adaptive optics provides real time correction of wavefront perturbations on ground-based telescopes and allow to reach the diffraction limit performances. Optimizing control and performance is a key issue for ever more demanding instruments on ever larger telescopes affected not only by atmospheric turbulence, but also by vibrations, windshake and tracking errors. Linear Quadratic Gaussian control achieves optimal correction when provided with a temporal model of the disturbance. We present in this paper the first on-sky results of a Kalman filter based LQG control with vibration mitigation on the CANARY instrument at the Nasmyth platform of the 4.2-m William Herschel Telescope (La Palma, Spain). The results demonstrate a clear improvement of performance for full LQG compared with standard integrator control, and assess the additional improvement brought by vibration filtering with a tip-tilt model identified from on-sky data (by 10 points of Strehl ratio), thus validating the strategy retained on the instrument SPHERE (eXtreme-AO system for extra-solar planets detection and characterization) at the VLT. The MOAO on-sky pathfinder CANARY features two AO configurations that have both been tested: single- conjugated AO and multi-object AO with NGS and NGS+ Rayleigh LGS, together with vibration mitigation on tip and tilt modes. We finally present the ongoing development done to commission such a control law on a regular Sodium laser Multi-Conjuagated Adaptive Optics (MCAO) system GeMS at the 8-m Gemini South Telescope. This implementation does not require new hardware and is already available in the real-time computer.

  19. Validating tyrosinase homologue melA as a photoacoustic reporter gene for imaging Escherichia coli

    Science.gov (United States)

    Paproski, Robert J.; Li, Yan; Barber, Quinn; Lewis, John D.; Campbell, Robert E.; Zemp, Roger

    2015-10-01

    To understand the pathogenic processes for infectious bacteria, appropriate research tools are required for replicating and characterizing infections. Fluorescence and bioluminescence imaging have primarily been used to image infections in animal models, but optical scattering in tissue significantly limits imaging depth and resolution. Photoacoustic imaging, which has improved depth-to-resolution ratio compared to conventional optical imaging, could be useful for visualizing melA-expressing bacteria since melA is a bacterial tyrosinase homologue which produces melanin. Escherichia coli-expressing melA was visibly dark in liquid culture. When melA-expressing bacteria in tubes were imaged with a VisualSonics Vevo LAZR system, the signal-to-noise ratio of a 9× dilution sample was 55, suggesting that ˜20 bacteria cells could be detected with our system. Multispectral (680, 700, 750, 800, 850, and 900 nm) analysis of the photoacoustic signal allowed unmixing of melA-expressing bacteria from blood. To compare photoacoustic reporter gene melA (using Vevo system) with luminescent and fluorescent reporter gene Nano-lantern (using Bruker Xtreme In-Vivo system), tubes of bacteria expressing melA or Nano-lantern were submerged 10 mm in 1% Intralipid, spaced between bioluminescence and fluorescence imaging could not resolve the two tubes of Nano-lantern-expressing bacteria even when the tubes were spaced 10 mm from each other. After injecting 100-μL of melA-expressing bacteria in the back flank of a chicken embryo, photoacoustic imaging allowed visualization of melA-expressing bacteria up to 10-mm deep into the embryo. Photoacoustic signal from melA could also be separated from deoxy- and oxy-hemoglobin signal observed within the embryo and chorioallantoic membrane. Our results suggest that melA is a useful photoacoustic reporter gene for visualizing bacteria, and further work incorporating photoacoustic reporters into infectious bacterial strains is warranted.

  20. A Short-term Wind Speed Prediction Model Using Phase-space Reconstructed Extreme Learning Machine%相空间重构的极端学习机短期风速预测模型

    Institute of Scientific and Technical Information of China (English)

    武峰雨; 乐秀瑶; 南东亮

    2013-01-01

    A quick and accurate prediction of wind speed can effectively reduce or avoid the adverse effects of wind farms on power system, and can as well improve the competitiveness of the wind farm in the electricity market. In this paper, according to the chaotic characteristics of the wind speed, a short-term wind speed prediction model using phase-space reconstructed extreme learning machine (ELM) is put forward. The decision of the delay time and embedding dimension is used to reconstruct the sample space, which makes the new sample better reflect the change characteristics of wind speed. On this basis, the ELM is applied for short-term wind speed prediction. Compared with the traditional prediction model, this method has the advantages of fast learning speed and good generalization performance. Therefore, a new method is provided for wind speed prediction.%对风速进行快速、准确的预测,可以有效地减小或避免风电场对电力系统的不利影响,同时提高风电场在电力市场中的竞争能力.根据风速具有混沌特性,提出一种相空间重构的极端学习机(extreme learningmachine,ELM)的短期风速预测模型,通过确定延迟时间和嵌入维数,对样本空间进行重构,使新的样本更能反映风速变化特性,在此基础上运用ELM进行短期风速预测.与传统的预测模型相比,该方法具有学习速度快、泛化性能好等优点,为风速预测提供了新方法.

  1. Development of the Coastal Storm Modeling System (CoSMoS) for predicting the impact of storms on high-energy, active-margin coasts

    Science.gov (United States)

    Barnard, Patrick; Maarten van Ormondt,; Erikson, Li H.; Jodi Eshleman,; Hapke, Cheryl J.; Peter Ruggiero,; Peter Adams,; Foxgrover, Amy

    2014-01-01

    The Coastal Storm Modeling System (CoSMoS) applies a predominantly deterministic framework to make detailed predictions (meter scale) of storm-induced coastal flooding, erosion, and cliff failures over large geographic scales (100s of kilometers). CoSMoS was developed for hindcast studies, operational applications (i.e., nowcasts and multiday forecasts), and future climate scenarios (i.e., sea-level rise + storms) to provide emergency responders and coastal planners with critical storm hazards information that may be used to increase public safety, mitigate physical damages, and more effectively manage and allocate resources within complex coastal settings. The prototype system, developed for the California coast, uses the global WAVEWATCH III wave model, the TOPEX/Poseidon satellite altimetry-based global tide model, and atmospheric-forcing data from either the US National Weather Service (operational mode) or Global Climate Models (future climate mode), to determine regional wave and water-level boundary conditions. These physical processes are dynamically downscaled using a series of nested Delft3D-WAVE (SWAN) and Delft3D-FLOW (FLOW) models and linked at the coast to tightly spaced XBeach (eXtreme Beach) cross-shore profile models and a Bayesian probabilistic cliff failure model. Hindcast testing demonstrates that, despite uncertainties in preexisting beach morphology over the ~500 km alongshore extent of the pilot study area, CoSMoS effectively identifies discrete sections of the coast (100s of meters) that are vulnerable to coastal hazards under a range of current and future oceanographic forcing conditions, and is therefore an effective tool for operational and future climate scenario planning.

  2. In vitro and in vivo corrosion of the novel magnesium alloy Mg-La-Nd-Zr: influence of the measurement technique and in vivo implant location.

    Science.gov (United States)

    Reifenrath, J; Marten, A-K; Angrisani, N; Eifler, R; Weizbauer, A

    2015-08-01

    For the evaluation of new magnesium-based alloys, many different in vitro and in vivo methods are used. It was the aim of the current study to perform in vitro and in vivo corrosion studies of the new alloy Mg-La-Nd-Zr for its evaluation as a promising new degradable material and to compare commonly used evaluation methods. Die casted and subsequent extruded cylindrical pins (Ø1.5 mm; length 7 mm, [Formula: see text]) were implanted subcutaneously ([Formula: see text]), intramuscular ([Formula: see text]) and intramedullary ([Formula: see text]) in female Lewis rats with a postoperative follow up of 8 weeks; subsequent μ-computed tomographical analyses (XTremeCT and μCT80) were performed as well as weight analysis prior to and after implantation. Cubes (5 mm  ×  4 mm  ×  4 mm; surface area, 1.12 cm(2); [Formula: see text]) were used for in vitro corrosion (HBSS and RPMI 1640 + 10% FBS medium) and cytocompatibility studies (L929 cells). First of all it could be stated that implant location strongly influences the in vivo corrosion rate. In particular, intramedullary implanted pins corroded faster than pins in a subcutaneous or intramuscular environment. Considering the different evaluation methods, the calculated ex vivo μCT-based corrosion rates resulted in comparable values to the corrosion rates calculated by the weight loss method, especially after chromatic acid treatment of the explanted pins. The in vitro methods used tend to show similar corrosion rates compared to in vivo corrosion, especially when a RPMI medium was used, and therefore are suitable to predict corrosion trends prior to in vivo studies. Regarding cytocompatibility, the novel magnesium alloy Mg-La-Nd-Zr showed sufficient cell viability and therefore can be considered as a promising alloy for further applications.

  3. 3种全瓷系统冠边缘适合性的比较%A comparison of three-dimensional marginal adaptation among three all-ceramic crown systems

    Institute of Scientific and Technical Information of China (English)

    张艳; 李江; 薛小琴; 陈振宇; 李小菊

    2011-01-01

    目的:比较临床常用3种全瓷系统(Kavo Everest、IPS e.max、In-Ceram alumina)冠的边缘适合性,为临床应用提供理论依据.方法:选取1颗无龋的离体前磨牙行牙体预备,其中(牙合)面预备2mm,颈部凹槽肩台,宽度为0.8mm,(牙合)聚合度为6°.双重印模法取模,每种系统分别制作10个冠修复体.然后采用双色硅橡胶印模法复制间隙模型,应用光学显微镜采集间隙图像及使用Auto CAD2006软件对其水平边缘间隙、垂直边缘间隙和绝对边缘间隙进行测量,将所得数据使用SPSS13.0软件包进行单因素方差分析.结果:3种全瓷系统制作的上颌前磨牙冠的水平边缘间隙的平均值在41.1~44.9μm,垂直边缘间隙的平均值在51.4~71.7μm,绝对边缘间隙的平均值在66.2~85.1μm.结论:本研究中,3种全瓷系统冠的绝对边缘间隙、垂直边缘间隙和水平边缘间隙均在临床可接受范围;然而,与In-Ceram alumina系统相比,IPS e.max和Kavo Everest系统制作的全瓷冠显示出较好的边缘适合性.%PURPOSE: This study was to compare the marginal adaptation of ingle crown made of 3 different allceramic systems (IPS e.max, In-Ceram alumina, Kavo Everest) in vitro using a light-body silicone supported by a heavybody silicone material. METHODS: The crowns were made for 1 extracted maxillary premolar prepared with a 0.8-ram chamfer margin and 6-degree tapered walls by milling. Ten crowns per system were fabricated. The horizontal marginal discrepancies, vertical marginal discrepancies and absolute marginal discrepancies were measured under an optical microscope at 39.2 magnification. The data were analyzed with one-way analysis of variance (ANOVA) using SPSS 13.0 software package. RESULTS: The results showed the mean values for horizontal marginal discrepancies were between 41.1μm and 44.9μm, for vertical marginal discrepancies were between 51.4μm and 71.7μm, and for absolute marginal discrepancies were between 66.2

  4. Seasonal variations in the sources of natural and anthropogenic lead deposited at the East Rongbuk Glacier in the high-altitude Himalayas

    Energy Technology Data Exchange (ETDEWEB)

    Burn-Nunes, Laurie, E-mail: L.Nunes@curtin.edu.au [Department of Imaging and Applied Physics, Curtin University, GPO Box U 1987, Perth 6845, Western Australia (Australia); Vallelonga, Paul [Centre for Ice and Climate, Niels Bohr Institute, University of Copenhagen, Juliane Maries Vej 30, DK-2100 Copenhagen Ø (Denmark); Lee, Khanghyun [Environmental Measurement and Analysis Center, National Institute of Environmental Research, Environmental Research Complex, Kyungseo-dong, Seo-gu, Incheon 404-170 (Korea, Republic of); Hong, Sungmin [Department of Ocean Sciences, Inha University, 100 Inha-ro, Nam-gu, Incheon 402-751 (Korea, Republic of); Burton, Graeme [Department of Imaging and Applied Physics, Curtin University, GPO Box U 1987, Perth 6845, Western Australia (Australia); Hou, Shugui [Key Laboratory of Coast and Island development of Ministry of Education, School of Geographic and Oceanographic Sciences, Nanjing University, Nanjing 210093 (China); Moy, Andrew [Department of the Environment, Australian Antarctic Division, Channel Highway, Kingston 7050, Tasmania (Australia); Antarctic Climate and Ecosystems Cooperative Research Centre, University of Tasmania, Private Bag 80, Hobart 7001, Tasmania (Australia); Edwards, Ross; Loss, Robert; Rosman, Kevin [Department of Imaging and Applied Physics, Curtin University, GPO Box U 1987, Perth 6845, Western Australia (Australia)

    2014-07-01

    Lead (Pb) isotopic compositions and concentrations, and barium (Ba) and indium (In) concentrations have been analysed at sub-annual resolution in three sections from a < 110 m ice core dated to the 18th and 20th centuries, as well as snow pit samples dated to 2004/2005, recovered from the East Rongbuk Glacier in the high-altitude Himalayas. Ice core sections indicate that atmospheric chemistry prior to ∼ 1953 was controlled by mineral dust inputs, with no discernible volcanic or anthropogenic contributions. Eighteenth century monsoon ice core chemistry is indicative of dominant contributions from local Himalayan sources; non-monsoon ice core chemistry is linked to contributions from local (Himalayan), regional (Indian/Thar Desert) and long-range (North Africa, Central Asia) sources. Twentieth century monsoon and non-monsoon ice core data demonstrate similar seasonal sources of mineral dust, however with a transition to less-radiogenic isotopic signatures that suggests local and regional climate/environmental change. The snow pit record demonstrates natural and anthropogenic contributions during both seasons, with increased anthropogenic influence during non-monsoon times. Monsoon anthropogenic inputs are most likely sourced to South/South-East Asia and/or India, whereas non-monsoon anthropogenic inputs are most likely sourced to India and Central Asia. - Highlights: • Pb isotopes in ice and snow show seasonality in Mt Everest atmospheric chemistry. • Local (Himalayan) mineral dust inputs are present year round. • Regional and long-range mineral dust inputs are evident during non-monsoon times. • Snow samples indicate increased anthropogenic inputs during non-monsoon times. • Anthropogenic inputs are linked with Indian, South Asian and Central Asian sources.

  5. MitraClip therapy in mitral regurgitation: a Markov model for the cost-effectiveness of a new therapeutic option.

    Science.gov (United States)

    Guerin, Patrice; Bourguignon, Sandrine; Jamet, Nicolas; Marque, Sébastien

    2016-07-01

    Introduction Mitral regurgitation is a heart condition resulting from blood flowing from the left ventricle towards the left atrium, increasing the risk of heart failure and mortality. While surgery can greatly reduce these risks, some patients are not eligible, resulting in medication being their only therapeutic alternative. The MitraClip (Abbot Vascular) is a medical device that is percutaneously implanted and designed to eliminate leaking of the mitral valve. Methods The efficacy of the MitraClip strategy vs medical management was assessed using a 4-state Markov model based on the mitral regurgitation grade (mitral regurgitation grade 0, I/II, and III/IV, and death). At each 1-month cycle, patients were or were not hospitalized. The model analyzed a fictional population of 1000 patients over a 5-year period from a national Health Insurance perspective. The primary end-point was the number of deaths avoided. Data from the EVEREST II High Risk Study patients were used along with a literature review. Results At 5 years, among the 1000 patients, 276 deaths were found to be avoidable with the MitraClip strategy. The incremental cost-effectiveness ratio (ICER) was €93,363 per death avoided. The annual ICER was calculated to take into consideration excess costs resulting from the MitraClip over the first year (€29,984 vs €8557 for the reference strategy) and the reduction of costs in following years (€3122 for MitraClip vs €8557 for reference strategy). Thus, the mean ICER was calculated to be €20,720 per death avoided. Conclusion The MitraClip is a novel alternative therapy for mitral insufficiency in patients ineligible for surgery that may offer a medico-economic advantage. PMID:26909557

  6. Immunology presentation at the 1990 NASA/NSF Antarctica Biomedical Science Working Group

    Science.gov (United States)

    Meehan, Richard T.

    1990-01-01

    An overview of methodology used for determining human in vitro lymphocyte activation, proliferation and effector cell function was presented and results of previous manned space flight immunology studies from Apollo through Shuttle were reviewed. Until the Shuttle era, lymphocyte assays were not very sensitive and had such large variations among normal subjects that it was difficult to define a consistent effect of space flight. More sensitive assay, however, even with Shuttle missions as brief as 6 days indicate depressed T-cell proliferative responses are routinely observed following space flight. Using a slight modification of the Shuttle assay, five different human stress-immunology models have been studied over the last 6 years in our lab. These have included: academic examinations of medical students having blood drawn during major test periods on three separate groups of first year students and two hypoxia studies (at 25,000 feet in a 6 week chamber ascent to the equivalent of Mount Everest and twice on Pikes Peak at 14,000 feet). These studies are particularly pertinent to Antarctica, since the altitude equivalent of 11,000 feet at the South Pole may affect some of the variables that are being measured in immunology, physiology or cognitive studies. An extravehicular study was performed drawing blood from 35 individuals before and immediately following a chamber exposure study. Preliminary results from 30 Shuttle astronauts investigated immunophenotype analysis and the role of a novel monocyte population in modulating the previously observed suppressed in vitro immune function. The results of the Air Force Academy cadet stress study were also presented.

  7. Fossil cladoceran record from Lake Piramide Inferiore (5067 m asl in the Nepalese Himalayas: biogeographical and paleoecological implications

    Directory of Open Access Journals (Sweden)

    Liisa Nevalainen

    2014-04-01

    Full Text Available We investigated 2500 years of community succession in Cladocera from the sediments of a mountain lake (Lake Piramide Inferiore located in the Khumbu Valley close to Mt. Everest in the Nepalese Himalayas. Our objective was to determine late Holocene changes in cladoceran species composition and abundance in a biogeographical context and with respect to previous proxy-based paleolimnological data (algal pigments and organic content. The results suggested that cladoceran fauna of Lake Piramide Inferiore was species-poor and dominated by Chydorus cf. sphaericus throughout the sequence. The sediment profile recorded the occurrence of Alona guttata type individuals, which were attributed to Alona werestschagini Sinev 1999 based on their morphology and the species' current distributional range, and this was the first record of its presence in the Himalayas. In addition, a periodic long-term succession of melanic Daphnia (Ctenodaphnia fusca Gurney, 1907 and non-melanic D. (Daphnia dentifera Forbes 1893 was observed in the sediments. The millennia-long cladoceran community changes, although subtle due to the C. cf. sphaericus dominance, were in general agreement with the previous proxy-data of lake productivity following the regional paleoclimatic development and apparently partly driven by bottom-up mechanisms. The periodic occurrence and success of D. fusca and D. dentifera throughout the late Holocene in Lake Piramide Inferiore, combined with the knowledge of their phenotypic properties (i.e. carapace melanization and previous investigations on their contemporary and past distribution in Khumbu Valley, suggested that they may have responded to altered underwater UV radiation regimes. Furthermore, they may have even periodically excluded each other subsequent to changes in the underwater UV environment. The results indicated the usefulness of fossil cladoceran analysis as a tool in biogeographical research, since the occurrence of species in space and

  8. Bhaktapur, Nepal: the MAL-ED birth cohort study in Nepal.

    Science.gov (United States)

    Shrestha, Prakash Sunder; Shrestha, Sanjaya Kumar; Bodhidatta, Ladaporn; Strand, Tor; Shrestha, Binob; Shrestha, Rita; Chandyo, Ram Krishna; Ulak, Manjeswori; Mason, Carl J

    2014-11-01

    The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study site in Nepal is located in the Bhaktapur municipality, 15 km east of Kathmandu, the capital city of Nepal. Bhaktapur, an ancient city famous for its traditional temples and buildings, is included on UNESCO's World Heritage List and is a major tourist attraction in Nepal. Nepal is a land-locked country located in South Asia between China and India with an area of 147 181 km(2), ranging from sea-level plains to Mount Everest, the world's highest peak. The total population as of the 2011 census was 26.6 million, with an average annual population growth rate of 1.4. Nepal is one of the world's least developed countries and is ranked 157 of 186 in the 2013 Human Development Report; one-third of the Nepali population lives below the poverty line. The current under-5 mortality rate is 54 per 1000 live births, the infant mortality rate is 46 per 1000 live births, and the neonatal mortality rate is 33 per 1000 live births. Vaccine coverage for all Expanded Program on Immunization vaccines is >80%. Among children, the most common diseases contributing to significant morbidity and mortality are acute respiratory infection and dehydration from severe diarrhea. In this article, we report on the geographic, demographic, and socioeconomic features of the Bhaktapur MAL-ED site and describe the data that informed our cohort recruitment strategy. PMID:25305301

  9. Research Objects for Sharing and Exchanging Research Data and Methods in Earth Science

    Science.gov (United States)

    Gómez Pérez, José Manuel; Palma, Raul

    2016-04-01

    Scientists in data-intensive disciplines increasingly call for models that go beyond the publication of datasets, allowing systematic capture of the lifecycle of scientific investigations and providing a single entry point for accessing information about (to name a few) the hypotheses investigated, the datasets used, the computations, observations and experiments carried out, their outcomes and provenance, the conclusions and findings that were derived, and even the scientists involved in a particular investigation. In this scenario, Research Objects provide a structured means to encapsulate such information and the associated methods involved, along with essential metadata and annotations aimed at both humans and computers. Research objects are therefore portable units of scientific knowledge that enable the sharing, preservation, scholarly communication, validation, and re-use of scientific outcomes. In this presentation we will focus on the application of the Research Object concept in observational disciplines and particularly Earth Science. We will present the main concepts behind research objects and discuss the challenges involved in the extension and adaptation of existing practices, modelling vocabularies, middleware and tools for these disciplines. By deploying research object technologies in Earth Science, we aim to enhance the portability of scientific materials and methods, the collaboration capabilities within and between teams of earth scientists, the quality and long-term preservation capabilities of the methods, and the means to communicate, validate and measure the impact of scientific outcomes. This work is being conducted in the context of the Horizon2020 EVER-EST project, the main objective of which is the development of a research object-centric virtual research environment for Earth Science communities.

  10. Effective Management of Trans boundary Landscapes - Geospatial Applications

    Science.gov (United States)

    Kotru, R.; Rawal, R. S.; Mathur, P. K.; Chettri, N.; Chaudhari, S. A.; Uddin, K.; Murthy, M. S. R.; Singh, S.

    2014-11-01

    The Convention on Biological Diversity advocates the use of landscape and ecosystem approaches for managing biodiversity, in recognition of the need for increased regional cooperation. In this context, ICIMOD and regional partners have evolved Transboundary Landscape concept to address the issues of conservation and sustainable use of natural resources and systems (e.g., biodiversity, rangelands, farming systems, forests, wetlands, and watersheds, etc.). This concept defines the landscapes by ecosystems rather than political/administrative boundaries. The Hindu Kush Himalayan (HKH) region is extremely heterogeneous, with complex inter linkages of biomes and habitats as well as strong upstream-downstream linkages related to the provisioning of ecosystem services. Seven such transboundary landscapes, identified across west to east extent of HKH, have been considered for programmatic cooperation, include: Wakhan, Karakoram-Pamir, Kailash, Everest, Kangchenjunga, Brahmaputra-Salween, and Cherrapunjee- Chittagong. The approach is people centered and considers the cultural conservation as an essential first step towards resource conservation efforts in the region. Considering the multi-scale requirements of study, the geospatial technology has been effectively adopted towards: (i) understanding temporal changes in landscapes, (ii) long term ecological and social monitoring, (ii) identifying potential bio corridors, (iii) assessing landscape level vulnerability due to climatic and non-climatic drivers, and (iv) developing local plans on extractions of high value economic species supporting livelihoods, agroforestry system and ecotourism, etc. We present here our recent experiences across different landscapes on assessment of three decadal changes, vegetation type mapping, assessment of socio-ecological drivers, corridor assessment, ecosystem services assessment, models for optimal natural resource use systems and long term socio-ecological monitoring.

  11. 近60年来雪豹(Uncia uncia)研究的文献分析%Literature analysis on snow leopard research during last six decades

    Institute of Scientific and Technical Information of China (English)

    王彦; 马鸣; 买尔旦·吐尔干

    2012-01-01

    The statistical analysis on the bibliographic record of scientific thesis on the snow leopard from international and domestic publications from 1950 -2010 and 1964 -2010 was conducted respectively. The philological principles and methods from different aspects such as year, author, institution and key word were used to investigate the distribution pattern, current status of snow leopard research thesis to reveal the current progress in this thematic research field worldwide. Results showed that the year 2008 was the most prosperous year with the highest record in the published literature both in China and overseas. The nations with relatively high output are China, Norway, the United States, India and Mongolia. China's specific research on the snow leopard was highly concentrated on the two major research teams as Xinjiang institute of Ecology and Geography and Beijing Institute of Zoology, Chinese Academy of Sciences. The hot topics of snow leopard research were those like conservation, ecology, human and wildlife conflict, biodiversity, endangered animal, gene, habitat, population density and food resource; the hot spots are such areas like the Qinghai Tibetan Plateau, Al-tuntagh National Reserve, the Altay Mountain, Hengduan Mountain, Tashkurghan, the Mount Everest and the Tomur Peak Natural Reserve.%应用文献计量学的原理和方法,就外文1950-2010年,中文1964-2010年公开发表的雪豹生物学研究文献进行统计和分析.分别从雪豹研究文献的发文年代、作者、机构和

  12. Reflectance-Based Estimation of Soil Heat Fluxes in the Texas High Plains

    Science.gov (United States)

    Gowda, P. H.; Colaizzi, P. D.; O'Shaughnessy, S.; Ha, W.; Howell, T. A.

    2010-12-01

    Soil heat flux (G) is one of the terms required for estimating evapotranspiration rates using an energy balance. Numerous reflectance-based models are available in the literature for estimating G fluxes. However, these models have shown wide variation in their performance. Therefore, operational ET remote sensing programs may require locally developed/calibrated models for accurately estimating G. The objective of this study was to develop and evaluate reflectance-based empirical G models for the semi-arid Texas High Plains. Soil heat flux was measured at 0.15 hz interval and averaged every 15 minutes at five different locations within a 4.7 ha lysimeter field with Pullman clay loam soil during the 2010 summer growing season. The field was planted to soybean and managed under dryland conditions. In each location, G was measured at 8 cm depth with two Campbell Scientific HFT3 soil heat flux plates. Soil temperature was measured at 2 and 6 cm above the soil heat flux plates. Soil moisture was measured in the 2-8 cm layer using Acclima SDI-12 sensors. Hourly G fluxes at the surface were calculated by adding the measured G fluxes at 8 cm to the energy stored above the heat flux plates. A multispectral radiometer (MSR, CROPSCAN, Inc.) and hand-held thermometer (EVEREST Interscience Inc.) measured surface reflectance in red and near infrared bandwidths and surface temperature (ST), respectively, daily at 11:30 AM CST to be consistent with the Landsat 5 overpass time. Fraction crop cover (FC) was measured by digital photographs taken twice a week. A set of G models was developed for estimating hourly fluxes based on measured reflectance, net radiation, ST, NDVI, and FC,. Resulting models were compared for performance with existing models available in the literature. In this presentation, we will discuss our G models for the Texas High Plains and the statistical results.

  13. Conservation reaches new heights.

    Science.gov (United States)

    Pepall, J; Khanal, P

    1992-10-01

    The conservation program with the management assistance of the Woodlands Mountain Institute in 2 contiguous parks, the Mount Everest National Park in Nepal and the Qomolangma Nature Reserve in China, in 2 countries is described. The focus is on conservation of the complex ecosystem with sustainable development by showing local people how to benefit from the park without environmental damage. Cultural diversity is as important as biological diversity. The area has been designated by UNESCO as a World Heritage Site with the "last pure ecological seed" of the Himalayas. The regional geography and culture are presented. Population growth has impacted natural resources through overgrazing, cultivation of marginal land, and deforestation; future plans to build a dam and road bordering the nature reserve pose other threats. Proposed management plans for the Makalu-Barun Nature Park (established in November 1991) and Conservation Area include a division of the park into nature reserve areas free of human activity, protected areas which permit traditional land use, and special sites and trail for tourists and religious pilgrims. The conservation area will act as a buffer for the park and provide economic opportunities; further subdivisions include land use for biodiversity protection, community forest and pasture, agroforestry, and agriculture and settlement. Efforts will be made to increase the welfare of women and local people; proposed projects include the introduction of higher milk-producing animals for stall feeding. Also proposed is a cultural and natural history museum. 70% of the project's resources will be directed to local community participation in consultation and park maintenance. The project is a model of how conservation and protection of natural resources can coexist with local economic development and participation; an integration of preservation of biological diversity, mountain wisdom, and the value of local people as resources for conservation.

  14. Conservation reaches new heights.

    Science.gov (United States)

    Pepall, J; Khanal, P

    1992-10-01

    The conservation program with the management assistance of the Woodlands Mountain Institute in 2 contiguous parks, the Mount Everest National Park in Nepal and the Qomolangma Nature Reserve in China, in 2 countries is described. The focus is on conservation of the complex ecosystem with sustainable development by showing local people how to benefit from the park without environmental damage. Cultural diversity is as important as biological diversity. The area has been designated by UNESCO as a World Heritage Site with the "last pure ecological seed" of the Himalayas. The regional geography and culture are presented. Population growth has impacted natural resources through overgrazing, cultivation of marginal land, and deforestation; future plans to build a dam and road bordering the nature reserve pose other threats. Proposed management plans for the Makalu-Barun Nature Park (established in November 1991) and Conservation Area include a division of the park into nature reserve areas free of human activity, protected areas which permit traditional land use, and special sites and trail for tourists and religious pilgrims. The conservation area will act as a buffer for the park and provide economic opportunities; further subdivisions include land use for biodiversity protection, community forest and pasture, agroforestry, and agriculture and settlement. Efforts will be made to increase the welfare of women and local people; proposed projects include the introduction of higher milk-producing animals for stall feeding. Also proposed is a cultural and natural history museum. 70% of the project's resources will be directed to local community participation in consultation and park maintenance. The project is a model of how conservation and protection of natural resources can coexist with local economic development and participation; an integration of preservation of biological diversity, mountain wisdom, and the value of local people as resources for conservation. PMID

  15. Aging, Tolerance to High Altitude, and Cardiorespiratory Response to Hypoxia.

    Science.gov (United States)

    Richalet, Jean-Paul; Lhuissier, François J

    2015-06-01

    Richalet, Jean-Paul, and François J. Lhuissier. Aging, tolerance to high altitude, and cardiorespiratory response to hypoxia. High Alt Med Biol. 16:117-124, 2015.--It is generally accepted that aging is rather protective, at least at moderate altitude. Some anecdotal reports even mention successful ascent of peaks over 8000 m and even Everest by elderly people. However, very few studies have explored the influence of aging on tolerance to high altitude and prevalence of acute high altitude related diseases, taking into account all confounding factors such as speed of ascent, altitude reached, sex, training status, and chemo-responsiveness. Changes in physiological responses to hypoxia with aging were assessed through a cross-sectional 20-year study including 4675 subjects (2789 men, 1886 women; 14-85 yrs old) and a longitudinal study including 30 subjects explored at a mean 10.4-year interval. In men, ventilatory response to hypoxia increased, while desaturation was less pronounced with aging. Cardiac response to hypoxia was blunted with aging in both genders. Similar results were found in the longitudinal study, with a decrease in cardiac and an increase in ventilatory response to hypoxia with aging. These adaptive responses were less pronounced or absent in post-menopausal untrained women. In conclusion, in normal healthy and active subjects, aging has no deleterious effect on cardiac and ventilatory responses to hypoxia, at least up to the eighth decade. Aging is not a contraindication for high altitude, as far as no pathological condition interferes and physical fitness is compatible with the intensity of the expected physical demand of one's individual. Physiological evaluation through hypoxic exercise testing before going to high altitude is helpful to detect risk factors of severe high altitude-related diseases. PMID:25946570

  16. The 2010 Pakistan floods: high-resolution simulations with the WRF model

    Science.gov (United States)

    Viterbo, Francesca; Parodi, Antonio; Molini, Luca; Provenzale, Antonello; von Hardenberg, Jost; Palazzi, Elisa

    2013-04-01

    Estimating current and future water resources in high mountain regions with complex orography is a difficult but crucial task. In particular, the French-Italian project PAPRIKA is focused on two specific regions in the Hindu-Kush -- Himalaya -- Karakorum (HKKH)region: the Shigar basin in Pakistan, at the feet of K2, and the Khumbu valley in Nepal, at the feet of Mount Everest. In this framework, we use the WRF model to simulate precipitation and meteorological conditions with high resolution in areas with extreme orographic slopes, comparing the model output with station and satellite data. Once validated the model, we shall run a set of three future time-slices at very high spatial resolution, in the periods 2046-2050, 2071-2075 and 2096-2100, nested in different climate change scenarios (EXtreme PREcipitation and Hydrological climate Scenario Simulations -EXPRESS-Hydro project). As a prelude to this study, here we discuss the simulation of specific, high-intensity rainfall events in this area. In this paper we focus on the 2010 Pakistan floods which began in late July 2010, producing heavy monsoon rains in the Khyber Pakhtunkhwa, Sindh, Punjab and Balochistan regions of Pakistan and affecting the Indus River basin. Approximately one-fifth of Pakistan's total land area was underwater, with a death toll of about 2000 people. This event has been simulated with the WRF model (version 3.3.) in cloud-permitting mode (d01 14 km and d02 3.5 km): different convective closures and microphysics parameterization have been used. A deeper understanding of the processes responsible for this event has been gained through comparison with rainfall depth observations, radiosounding data and geostationary/polar satellite images.

  17. Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation.

    Directory of Open Access Journals (Sweden)

    Mario Siervo

    Full Text Available OBJECTIVES: The mechanisms by which low oxygen availability are associated with the development of insulin resistance remain obscure. We thus investigated the relationship between such gluco-insular derangements in response to sustained (hypobaric hypoxemia, and changes in biomarkers of oxidative stress, inflammation and counter-regulatory hormone responses. METHODS: After baseline testing in London (75 m, 24 subjects ascended from Kathmandu (1,300 m to Everest Base Camp (EBC;5,300 m over 13 days. Of these, 14 ascended higher, with 8 reaching the summit (8,848 m. Assessments were conducted at baseline, during ascent to EBC, and 1, 6 and 8 week(s thereafter. Changes in body weight and indices of gluco-insular control were measured (glucose, insulin, C-Peptide, homeostasis model assessment of insulin resistance [HOMA-IR] along with biomarkers of oxidative stress (4-hydroxy-2-nonenal-HNE, inflammation (Interleukin-6 [IL-6] and counter-regulatory hormones (glucagon, adrenalin, noradrenalin. In addition, peripheral oxygen saturation (SpO2 and venous blood lactate concentrations were determined. RESULTS: SpO2 fell significantly from 98.0% at sea level to 82.0% on arrival at 5,300 m. Whilst glucose levels remained stable, insulin and C-Peptide concentrations increased by >200% during the last 2 weeks. Increases in fasting insulin, HOMA-IR and glucagon correlated with increases in markers of oxidative stress (4-HNE and inflammation (IL-6. Lactate levels progressively increased during ascent and remained significantly elevated until week 8. Subjects lost on average 7.3 kg in body weight. CONCLUSIONS: Sustained hypoxemia is associated with insulin resistance, whose magnitude correlates with the degree of oxidative stress and inflammation. The role of 4-HNE and IL-6 as key players in modifying the association between sustained hypoxia and insulin resistance merits further investigation.

  18. Light absorption characteristics of carbonaceous aerosols in two remote stations of the southern fringe of the Tibetan Plateau, China

    Science.gov (United States)

    Li, Chaoliu; Yan, Fangping; Kang, Shichang; Chen, Pengfei; Hu, Zhaofu; Gao, Shaopeng; Qu, Bin; Sillanpää, Mika

    2016-10-01

    Light absorption characteristics of carbonaceous aerosols are key considerations in climate forcing research. However, in situ measurement data are limited, especially on the Tibetan Plateau (TP) - the Third Pole of the world. In this study, the mass absorption cross section (MAC) of elemental carbon (EC) and water soluble organic carbon (WSOC) of total suspended particles at two high-altitude stations (Lulang station and Everest station) in the Tibetan Plateau (TP) were investigated. The mean MACEC values at 632 nm were 6.85 ± 1.39 m2 g-1 and 6.49 ± 2.81 m2 g-1 at these two stations, both of which showed little seasonal variations and were slightly higher than those of EC of uncoated particles, indicating that the enhancement of MACEC by factors such as coating with organic aerosols was not significant. The mean MACWSOC values at 365 nm were 0.84 ± 0.40 m2 g-1 and 1.18 ± 0.64 m2 g-1 at the two stations. Obvious seasonal variations of high and low MACWSOC values appeared in winter and summer, respectively, mainly reflecting photobleaching of light absorption components of WSOC caused by fluctuations in sunlight intensity. Therefore, this phenomenon might also exists in other remote areas of the world. The relative contributions of radiative forcing of WSOC to EC were 6.03 ± 3.62% and 11.41 ± 7.08% at these two stations, with a higher ratio in winter. As a result, both the contribution of WSOC to radiative forcing of carbonaceous aerosols and its seasonal variation need to be considered in radiative forcing related study.

  19. Geodetic Constraint of the M=7.6 Bhuj 2001 Rupture and Convergence Across the Rann of Kachchh 1856-2001

    Science.gov (United States)

    Bilham, R.; Wallace, K.; Gaur, V.; Bendick, R.; Kier, G.; Blume, F.

    2002-12-01

    Teleseismic estimates of the Mw=7.6 Bhuj earthquake indicate that slip extended from 35 km to 9 km depth, and approximately 40 km along strike with a mean slip of 3-6 m. A search for historic triangulation markers in February 2001 recovered few control points, however, in June 2001 eighteen historic survey monuments were re-measured in a region within 150 km of the epicenter, with at least 10 points within 40 km of the inferred rupture. A leveling line close to the epicenter was remeasured between Feb and June 2001 by the Survey of India that showed 0.7 m of subsidence south of the epicenter. The GPS data were compared with the published 1856 trigonometrical survey in two ways, first by assuming that points remote from the epicenter had not changed in relative position since 1856, and second by assuming the validity of the 1856 Everest-spheroid parameters to compare with GPS 2001 positions. In each case deformation near the epicenter was less than 1.5 m at the points recovered, consistent with the parameters of the earthquake determined from teleseismic studies. The principal difference between the two reduction methods was that although both methods showed that little strain in the Kathiawar Peninsula SSE of the epicenter in the last 150 years, the coordinate transform analysis revealed 2 m of convergence across the Rann of Kachchh north of the epicenter. A number of reasons for this convergence can be invoked: errors in the original survey, an earthquake in 1856 that is known to have disturbed some of the trigonometrical point positions, or real convergence across the rift zone at a rate of roughly 1 cm/year. The first explanation is considered unlikely since the lines were from observations on elevated bedrock points. The second and third explanations indicate that convergence across this ancient rift is occurring at an unexpectedly high rate for a mid-plate setting.

  20. Citizen Science in the Himalaya: The Sherpa-Scientist Initiative

    Science.gov (United States)

    Horodyskyj, U. N.; Breashears, D.; Rowe, P.

    2015-12-01

    Since the non-profit educational group, Black Ice Himalaya, launched in 2011 our goal has been to involve local communities in our research expeditions, in the form of a Sherpa-Scientist Initiative (SSI). This goes beyond simply helping with gear carries to research sites. It involves training the local Sherpa in equipment set-up, data collection, and analysis processes, with the goal of turning over this task to local communities and villages in the future. As the terrain continues to change - with the growth and expansion of glacial lakes, along with accumulation of pollutants on snow at higher altitudes - this training program presents an excellent opportunity for long-term data collection in sensitive alpine regions. In association with GlacierWorks and Midwest ROV LLC, skill training has included gigapan high-resolution photography, installing (and downloading) multiple time lapse cameras to track hour-by-hour glacial lake changes; lake bathymetry mapping using side-scan sonar from an unmanned towed platform; installing and managing weather stations; collecting and analyzing data from ASD field spectrometers; and collecting/filtering snow samples to look for contaminants (pollutants) affecting snow melt from 4000 - 6000 meters. A field manual documenting this work and intended to raise awareness of glacial trekking hazards has been disseminated to the International Centre for Integrated Mountain Development (ICIMOD) and Sagarmatha (Everest) National Park. In 2016-17, in collaboration with Vanguard Diving and Exploration, OpenROV, and Midwest ROV LLC, efforts will include SCUBA diving into glacial lakes to collect scientific data, with continued Sherpa training on how to assemble and use portable remotely piloted submersibles to aid in the assessment of glacial lake hazards.

  1. Technology demonstration for reusable launchers

    Science.gov (United States)

    Baiocco, P.; Bonnal, Ch.

    2016-03-01

    Reusable launchers have been studied under CNES contracts for more than 30 years, with early concepts such as STS-2000 or Oriflamme, more recently with very significant efforts devoted to Liquid Fly Back Boosters as with the Bargouzin project led with Tsniimash, TSTO with the Everest concept studied by Airbus-DS as prime contractor or the RFS Reusable First Stage concept of a large first stage associated to a cryotechnic second stage. These investigations, summarized in the first part of the paper, enabled CNES to identify clearly the technology requirements associated to reusability, as well as cost efficiency through detailed non-recurring costs and mission costs analysis. In parallel, CNES set in place development logic for sub-systems and equipment based on demonstrators, hardware test benches enabling maturation of technologies up to a TRL such that an actual development can be decided with limited risk. This philosophy has been applied so far to a large number of cases, such as TPTech and TPX for Hydrogen turbo pump, GGPX as demonstrator of innovative gas generator, HX demonstrator of modern cryotechnic upper stage with a dozen of different objectives (Thermal Protection, 20K Helium storage, measurements …). This virtuous approach, "learn as you test", is currently applied in the phased approach towards scaled down reusable booster stage, whose possibility to be used as first stage of a microlaunch vehicle is under investigation. The selected technologies allow paving the way towards reusable booster stages for Ariane 6 evolutions or main reusable stage for a further generation of heavy launchers. The paper describes the logic behind this project, together with the demonstration objectives set for the various sub-systems as well as operations.

  2. Atmospheric Modelling for Air Quality Study over the complex Himalayas

    Science.gov (United States)

    Surapipith, Vanisa; Panday, Arnico; Mukherji, Aditi; Banmali Pradhan, Bidya; Blumer, Sandro

    2014-05-01

    An Atmospheric Modelling System has been set up at International Centre for Integrated Mountain Development (ICIMOD) for the assessment of Air Quality across the Himalaya mountain ranges. The Weather Research and Forecasting (WRF) model version 3.5 has been implemented over the regional domain, stretching across 4995 x 4455 km2 centred at Ichhyakamana , the ICIMOD newly setting-up mountain-peak station (1860 m) in central Nepal, and covering terrains from sea-level to the Everest (8848 m). Simulation is carried out for the winter time period, i.e. December 2012 to February 2013, when there was an intensive field campaign SusKat, where at least 7 super stations were collecting meteorology and chemical parameters on various sites. The very complex terrain requires a high horizontal resolution (1 × 1 km2), which is achieved by nesting the domain of interest, e.g. Kathmandu Valley, into 3 coarser ones (27, 9, 3 km resolution). Model validation is performed against the field data as well as satellite data, and the challenge of capturing the necessary atmospheric processes is discussed, before moving forward with the fully coupled chemistry module (WRF-Chem), having local and regional emission databases as input. The effort aims at finding a better understanding of the atmospheric processes and air quality impact on the mountain population, as well as the impact of the long-range transport, particularly of Black Carbon aerosol deposition, to the radiative budget over the Himalayan glaciers. The higher rate of snowcap melting, and shrinkage of permafrost as noticed by glaciologists is a concern. Better prediction will supply crucial information to form the proper mitigation and adaptation strategies for saving people lives across the Himalayas in the changing climate.

  3. Resolving the impact of stratosphere-to-troposphere transport on the sulfur cycle and surface ozone over the Tibetan Plateau using a cosmogenic 35S tracer

    Science.gov (United States)

    Lin, Mang; Zhang, Zhisheng; Su, Lin; Hill-Falkenthal, Jason; Priyadarshi, Antra; Zhang, Qianggong; Zhang, Guoshuai; Kang, Shichang; Chan, Chuen-Yu; Thiemens, Mark H.

    2016-01-01

    The Himalayas were recently identified as a global hot spot for deep stratosphere-to-troposphere transport (STT) in spring. Although the STT in this region may play a vital role in tropospheric chemistry, the hydrological cycle and aquatic ecosystems in Asia, there is no direct measurement of a chemical stratospheric tracer to verify and evaluate its possible impacts. Here we use cosmogenic 35S as a tracer for air masses originating in the stratosphere and transported downward. We measure concentrations of 35S in fresh surface snow and river runoff samples collected from Mount Everest in April 2013 to be more than 10 times higher than previously reported by any surface measurement, in support of the Himalayas as a gateway of springtime STT. In light of this result, measurements of 35SO2 and 35SO42- at Nam Co in spring 2011 are reanalyzed to investigate the magnitudes of stratospheric air masses from the Himalayas to the tropospheric sulfur cycle and surface O3 level over the Tibetan Plateau. A simple one-box model reveals that the oxidative lifetime of SO2 is reduced in aged STT plumes. Triple oxygen isotopic measurements of sulfate samples suggest that enhanced O3 levels may shift the oxidation pathway of SO2 in the troposphere, which may be constrained by further intensive sampling and measurements. Comparison with surface O3 measurements and traditional meteorological tracing methods shows that 35S is a potentially unique and sensitive tracer to quantify the contribution of stratospheric air to surface O3 levels in fresh or aged STT plumes.

  4. Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch.

    Directory of Open Access Journals (Sweden)

    Dan Zhou

    2008-10-01

    Full Text Available Hypoxia-induced cell injury has been related to multiple pathological conditions. In order to render hypoxia-sensitive cells and tissues resistant to low O2 environment, in this current study, we used Drosophila melanogaster as a model to dissect the mechanisms underlying hypoxia-tolerance. A D. melanogaster strain that lives perpetually in an extremely low-oxygen environment (4% O2, an oxygen level that is equivalent to that over about 4,000 m above Mt. Everest was generated through laboratory selection pressure using a continuing reduction of O2 over many generations. This phenotype is genetically stable since selected flies, after several generations in room air, survive at this low O2 level. Gene expression profiling showed striking differences between tolerant and naïve flies, in larvae and adults, both quantitatively and qualitatively. Up-regulated genes in the tolerant flies included signal transduction pathways (e.g., Notch and Toll/Imd pathways, but metabolic genes were remarkably down-regulated in the larvae. Furthermore, a different allelic frequency and enzymatic activity of the triose phosphate isomerase (TPI was present in the tolerant versus naïve flies. The transcriptional suppressor, hairy, was up-regulated in the microarrays and its binding elements were present in the regulatory region of the specifically down-regulated metabolic genes but not others, and mutations in hairy significantly reduced hypoxia tolerance. We conclude that, the hypoxia-selected flies: (a altered their gene expression and genetic code, and (b coordinated their metabolic suppression, especially during development, with hairy acting as a metabolic switch, thus playing a crucial role in hypoxia-tolerance.

  5. Benzolamide improves oxygenation and reduces acute mountain sickness during a high-altitude trek and has fewer side effects than acetazolamide at sea level.

    Science.gov (United States)

    Collier, David J; Wolff, Chris B; Hedges, Anne-Marie; Nathan, John; Flower, Rod J; Milledge, James S; Swenson, Erik R

    2016-06-01

    Acetazolamide is the standard carbonic anhydrase (CA) inhibitor used for acute mountain sickness (AMS), however some of its undesirable effects are related to intracellular penetrance into many tissues, including across the blood-brain barrier. Benzolamide is a much more hydrophilic inhibitor, which nonetheless retains a strong renal action to engender a metabolic acidosis and ventilatory stimulus that improves oxygenation at high altitude and reduces AMS. We tested the effectiveness of benzolamide versus placebo in a first field study of the drug as prophylaxis for AMS during an ascent to the Everest Base Camp (5340 m). In two other studies performed at sea level to test side effect differences between acetazolamide and benzolamide, we assessed physiological actions and psychomotor side effects of two doses of acetazolamide (250 and 1000 mg) in one group of healthy subjects and in another group compared acetazolamide (500 mg), benzolamide (200 mg) and lorazepam (2 mg) as an active comparator for central nervous system (CNS) effects. At high altitude, benzolamide-treated subjects maintained better arterial oxygenation at all altitudes (3-6% higher at all altitudes above 4200 m) than placebo-treated subjects and reduced AMS severity by roughly 50%. We found benzolamide had fewer side effects, some of which are symptoms of AMS, than any of the acetazolamide doses in Studies 1 and 2, but equal physiological effects on renal function. The psychomotor side effects of acetazolamide were dose dependent. We conclude that benzolamide is very effective for AMS prophylaxis. With its lesser CNS effects, benzolamide may be superior to acetazolamide, in part, because some of the side effects of acetazolamide may contribute to and be mistaken for AMS. PMID:27433337

  6. Why is it so difficult to measure big G?

    Science.gov (United States)

    Faller, James

    2015-04-01

    The determination of the Newtonian constant of gravitation, big G, continues to be one of Nature's greatest challenges to the skills and cunning of experimental physicists. The reasons: Big G is small, scientists are human, and error budgets are flawed. In spite of the fact that on the scale of the Universe, big G's effects are so big as to single handedly hold everything together, on the scale of a single research laboratory, big G's effects are so small that they go unnoticed. And, it is this ``smallness'' that makes the determination of this (seemingly unrelated to the rest of physics) fundamental constant so difficult. Furthermore, because they are human, scientists want to get the ``right'' (read previously obtained) answer; and this goal can affect their otherwise good judgment. Finally, error budgets are fundamentally flawed because they cannot make allowances for error sources that have not been thought of. During its nearly 300 year measurement history, the accuracy with which G is known has barely increased by three orders of magnitude; during the past 30 years the progress, measured by agreement rather than claimed accuracy of individual measurements, has been essentially zero. Nevertheless, this Mount Everest of precision measurement continues to provide an experimental challenge upon which metrologists can hone their laboratory skills for generations to come. Finally, this presentation will be understandable and interesting for ``students of all ages.'' In this year of GR100, Einstein will be mentioned more than once, and my hope is that some of you who would not normally ``risk'' attending a talk outside of your own specialty or discipline will consider coming to this one.

  7. Personas con diabetes mellitus tipo 2 y su capacidad de agencia de autocuidado, Cartagena Pessoas com diabete mellitus tipo 2 e sua capacidade de agência de autocuidado, Cartagena Patients with Type 2 Mellitus Diabetes and their Self-Care Agency Capacity, Cartagena

    Directory of Open Access Journals (Sweden)

    Arleth Herrera Lían

    2012-07-01

    Full Text Available Contexto: La diabetes mellitus tipo 2 se constituye en un problema de salud pública por las repercusiones bio-psicosociales, la presencia de complicaciones neurovasculares y metabólicas en la persona que la padece. Enfermería cumple un papel importante a través de la educación y la capacitación. Objetivo: Identificar la capacidad de agencia de autocuidado de las personas con diagnóstico de diabetes mellitus tipo 2, inscritos en los programas de control de diabetes en 19 UPAS de Cartagena. Metodología: diseño descriptivo con abordaje cuantitativo, en una muestra de 225 adultos de ambos sexos, seleccionados en forma aleatoria. La capacidad de agencia de autocuidado se identificó con la escala de Valoración de las capacidades de autocuidado, desarrollada por Isenberg y Everest, traducida al español por Gallegos y adaptada por la Universidad Nacional de Colombia. Para presentar los datos se utilizó la estadística descriptiva, los resultados se presentan en tablas y gráficas. Resultados: Predominó el sexo femenino (68,4 %; la unión libre (59,1 %; escolaridad (50,6 % con básica primaria; bajos ingresos económicos (menos de un salario mínimo mensual vigente, 34.7 %. Al valorar la capacidad de agencia de autocuidado, el 73.8 % de los pacientes obtuvo una calificación de muy buena (76-100 %, según escala. Al valorar los aspectos comprendidos en la escala se encontró que más del 50 % de las personas siempre sacan tiempo para ellos, piden explicación sobre su salud, examinan su cuerpo para ver si hay cambios y conservan un ambiente limpio. Conclusiones: El apoyo social recibido por los pacientes con diabetes mellitus tipo 2 y las prácticas de higiene personal y del entorno, el conocimiento y la adherencia a la dieta, permiten a los pacientes una buena capacidad de agencia de autocuidado.Contexto: A diabete mellitus tipo 2 se configura como um problema de saúde pública por conta das repercussões biopsicossociais e da presen

  8. Parámetros fisiológicos en caninos pre y post competencia de Agility en Bogotá, Colombia

    Directory of Open Access Journals (Sweden)

    Jorge Hernando Forero López

    2006-12-01

    Full Text Available El estudio se llevó a cabo en la ciudad de Bogotá, ubicada a una altura media 2600 msnm, con temperatura promedio de 14°C. Se realizó un muestreo en el Polideportivo el Salitre y otro en el parque central de Modelia. El objetivo principal fue monitorear y estandarizar los cambios fisiológicos que se presentan en caninos atletas, como respuesta al ejercicio realizado en pruebas de Agility. Se muestrearon 15 caninos hembras de diferentes razas practicantes del Agility, de las escuelas Atalanta y X-treme Dog. El control se obtuvo de individuos en reposo, previo al ejercicio, inmediatamente a su llegada al área de investigación, donde se situaron las pistas para el entrenamiento, que incluía la toma de temperatura rectal, frecuencia de pulso, frecuencia respiratoria y de sangre arterial (arteria femoral. La muestra arterial se procesó con analizador sanguíneo portátil, obteniendo de hematocrito, hemoglobina, sodio, potasio, cloruro, nitrógeno uréico (BUN, glucosa, lactato, pH sanguíneo, presión de dióxido de carbono (PCO2, presión de oxígeno (PO2, bicarbonato, tensión de dióxido de carbono(TCO2, saturación de oxígeno (SO2, exceso de base (BE, anion gap y osmolalidad. Luego se inició el entrenamiento, simulando una competencia real, donde cada canino pasó cuatro veces por pista, y al final se monitorearon, siguiendo el procedimiento descrito para el control. Se compararon los resultados pre y post ejercicio, presentándose: aumento para temperatura, frecuencia respiratoria, pulso, pH, hematocrito, hemoglobina, sodio, cloro y osmolalidad (p<0,001; incremento en los valores de potasio, lactato y glucosa (p<0,01; ascenso para PO2, SO2 y BUN (p<0,05; descenso para PCO2, TCO2, BE y Anión Gap (p<0,001. Se concluye que los caninos deportistas en Bogotá presentan hipertermia, taquicardia, hipocapnia, alcalosis respiratoria acompañada de una acidosis metabólica compensatoria y hemoconcentración por una deshidratación clasificada

  9. EUV sources for EUV lithography in alpha-, beta-, and high volume chip manufacturing: an update on GDPP and LPP technology

    Science.gov (United States)

    Stamm, U.; Kleinschmidt, J.; Gabel, K.; Hergenhan, G.; Ziener, C.; Schriever, G.; Ahmad, I.; Bolshukhin, D.; Brudermann, J.; de Bruijn, R.; Chin, T. D.; Geier, A.; Gotze, S.; Keller, A.; Korobotchko, V.; Mader, B.; Ringling, J.; Brauner, T.

    2005-05-01

    In the paper we report about the progress made at XTREME technologies in the development of EUV sources based on gas discharge produced plasma (GDPP) technologies and laser produced plasma (LPP) technologies. First prototype xenon GDPP sources of the type XTS 13-35 based on the Z-pinch principle with 35 W power in 2π sr have been integrated into micro-exposure tools from Exitech, UK. Specifications of the EUV sources and experience of integration as well as data about component and optics lifetime are presented. In the source development program for Beta exposure tools and high volume manufacturing exposure tools both tin and xenon have been investigated as fuel for the EUV sources. Development progress in porous metal cooling technology as well as pulsed power circuit design has led to GDPP sources with xenon fuel continuous operating with an output power of 200 W in 2π sr at 4500 Hz repetition rate. With tin fuel an output power of 400 W in 2π sr was obtained leaving all other conditions unaltered with respect to the xenon based source. The performance of the xenon fueled sources is sufficiently good to fulfill all requirements up to the beta tool level. For both the xenon and the tin GDPP sources detailed data about source performance are reported, including component lifetime and optics lifetime. The status of the integration of the sources with grazing incidence collector optics is discussed. Theoretical estimations of collection efficiencies are compared with experimental data to determine the loss mechanisms in the beam path. Specifically contamination issues related to tin as target material as well as debris mitigation in tin sources is addressed. As driver lasers for the LPP source research diode-pumped Nd:YAG lasers have been used to generate EUV emitting plasma. As target material xenon has been employed. Conversion efficiencies have been measured and currently the maximum conversion efficiency amounts to 1 %. The laser driver power of 1.2 kW is

  10. Validating tyrosinase homologue melA as a photoacoustic reporter gene for imaging Escherichia coli.

    Science.gov (United States)

    Paproski, Robert J; Li, Yan; Barber, Quinn; Lewis, John D; Campbell, Robert E; Zemp, Roger

    2015-10-01

    To understand the pathogenic processes for infectious bacteria, appropriate research tools are required for replicating and characterizing infections. Fluorescence and bioluminescence imaging have primarily been used to image infections in animal models, but optical scattering in tissue significantly limits imaging depth and resolution. Photoacoustic imaging, which has improved depth-to-resolution ratio compared to conventional optical imaging, could be useful for visualizing melA-expressing bacteria since melA is a bacterial tyrosinase homologue which produces melanin. Escherichia coli-expressing melA was visibly dark in liquid culture. When melA-expressing bacteria in tubes were imaged with a VisualSonics Vevo LAZR system, the signal-to-noise ratio of a 9×dilution sample was 55, suggesting that ∼20 bacteria cells could be detected with our system. Multispectral (680, 700, 750, 800, 850, and 900 nm) analysis of the photoacoustic signal allowed unmixing of melA-expressing bacteria from blood. To compare photoacoustic reporter gene melA (using Vevo system) with luminescent and fluorescent reporter gene Nano-lantern (using Bruker Xtreme In-Vivo system), tubes of bacteria expressing melA or Nano-lantern were submerged 10 mm in 1% Intralipid, spaced between Photoacoustic imaging could resolve the two tubes of melA-expressing bacteria even when the tubes were less than 1 mm from each other, while bioluminescence and fluorescence imaging could not resolve the two tubes of Nano-lantern-expressing bacteria even when the tubes were spaced 10 mm from each other. After injecting 100-μL of melA-expressing bacteria in the back flank of a chicken embryo, photoacoustic imaging allowed visualization of melA-expressing bacteria up to 10-mm deep into the embryo. Photoacoustic signal from melA could also be separated from deoxy- and oxy-hemoglobin signal observed within the embryo and chorioallantoic membrane. Our results suggest that melA is a useful photoacoustic reporter gene

  11. Significance of QRS duration and left bundle branch block in development and course of congestive heart failure

    Directory of Open Access Journals (Sweden)

    Bockeria L. A.

    2012-03-01

    Full Text Available Patients with severe chronic heart failure (CHF often have such intraventricular conduction disturbances as left bundle branch block which show morphological and QRS-duration changes on ECG and result in evident intra- and interventricular dyssinchrony. Delayed left ventricular activation via interventricular septum results in evident asynchrony at the beginning of left and right ventricular contration. Diagnostic significance of ECG data increases in presence of CHF clinical signs, especially echocardiographic signs of myocardial dysfunction. EVEREST study analyzed the influence of QRS duration on number of hospital admissions and mortality in patients with CHF. The study included 2962 patients, 1614 of them had normal QRS duration – less than 120 ms, 1321 patients had increased QRS duration – more than 120 ms. 678 deaths occurred during followup period, 307 (18.7% of them were from group with normal QRS duration and 371 (28.1% – from group with increased QRS interval. Mortality rate due to cardiovascular causes was more significant in patients with increased QRS. In 3 months of follow-up the mortality rate was 21.1% in patients with increased QRS and 14.6% in patients with normal QRS. In 9.9 months of follow-up the rates were 41.6% and 32.4%, respectively. Different international studies showed that isolated right ventricular pacing resulted in prolongation of QRS complex and contributed to CHF progression. 2010 patients were randomized in MOST-study which aimed to compare dual chamber pacing and right ventricular pacing. Reduction of CHF symptoms was noted in the course of study in patients who underwent dual chamber pacing, while M.O. Sweeney et al. analyzed the results of treatment of 1339 patients with initially normal QRS duration. However the authors revealed a higher rate in group of right ventricular pacing which proved the higher rates of hospital admission for CHF and more frequent rates for atrial fibrillation occurrence

  12. Himalayan glaciers: understanding contrasting patterns of glacier behavior using multi-temporal satellite imagery

    Science.gov (United States)

    Racoviteanu, A.

    2014-12-01

    High rates of glacier retreat for the last decades are often reported, and believed to be induced by 20th century climate changes. However, regional glacier fluctuations are complex, and depend on a combination of climate and local topography. Furthermore, in ares such as the Hindu-Kush Himalaya, there are concerns about warming, decreasing monsoon precipitation and their impact on local glacier regimes. Currently, the challenge is in understanding the magnitude of feedbacks between large-scale climate forcing and small-scale glacier behavior. Spatio-temporal patterns of glacier distribution are still llimited in some areas of the high Hindu-Kush Himalaya, but multi-temporal satellite imagery has helped fill spatial and temporal gaps in regional glacier parameters in the last decade. Here I present a synopsis of the behavior of glaciers across the Himalaya, following a west to east gradient. In particular, I focus on spatial patterns of glacier parameters in the eastern Himalaya, which I investigate at multi-spatial scales using remote sensing data from declassified Corona, ASTER, Landsat ETM+, Quickbird and Worldview2 sensors. I also present the use of high-resolution imagery, including texture and thermal analysis for mapping glacier features at small scale, which are particularly useful in understanding surface trends of debris-covered glaciers, which are prevalent in the Himalaya. I compare and contrast spatial patterns of glacier area and élévation changes in the monsoon-influenced eastern Himalaya (the Everest region in the Nepal Himalaya and Sikkim in the Indian Himalaya) with other observations from the dry western Indian Himalaya (Ladakh and Lahul-Spiti), both field measurements and remote sensing-based. In the eastern Himalaya, results point to glacier area change of -0.24 % ± 0.08% per year from the 1960's to the 2006's, with a higher rate of retreat in the last decade (-0.43% /yr). Debris-covered glacier tongues show thinning trends of -30.8 m± 39 m

  13. Carbonaceous aerosols on the south edge of the Tibetan Plateau: concentrations, seasonality and sources

    Directory of Open Access Journals (Sweden)

    Z. Cong

    2014-10-01

    Full Text Available To quantitatively evaluate the effect of carbonaceous aerosols on the south edge of the Tibetan Plateau, aerosol samples were collected weekly from August 2009 to July 2010 at Mt. Everest (Qomolangma Station for Atmospheric and Environmental Observation and Research, briefly QOMS, 28.36° N, 86.95° E, 4276 m a.s.l.. The samples were analyzed for organic carbon (OC, elemental carbon (EC, water-soluble organic carbon (WSOC and major ions. The average concentrations of OC, EC and WSOC were 1.43, 0.25 and 0.77 μg m−3, respectively. The concentration levels of OC and EC at QOMS are comparable to those at high elevation sites on the southern slopes of the Himalayas (Langtang and NCO-P, but three to six times lower than those at Manora Peak, India and Godavari, Nepal. Sulfate was the most abundant anion species followed by nitrate, accounting for 25 and 12% of total ionic mass, respectively. Ca2+ was the most abundant cation species (annual average of 0.88 μg m−3. The various aerosol compositions showed distinctive seasonality. The dust loading, represented by Ca2+ concentration, was relatively constant throughout the year. While OC, EC and other ionic species (NH4+, K+, NO3−, and SO42− exhibited a pronounced peak in the pre-monsoon period and a minimum in the monsoon season. Similar seasonal trends of aerosol composition were also reported previously from the southern slope of the Himalayas, such as Langtang and NCO-P. This phenomenon indicates that both slopes of Himalayas share a common atmospheric environment regime. The strong correlation of OC and EC in QOMS aerosols with K+ and levoglucosan indicates that they were mainly originated from biomass burning. The active fire spots observed by MODIS and their backward trajectories further demonstrate that in pre-monsoon season, agricultural and forest fires in the northern India and Nepal were most likely sources of carbonaceous aerosol at QOMS. In addition to large-scale atmospheric

  14. Carbonaceous aerosols on the south edge of the Tibetan Plateau: concentrations, seasonality and sources

    Science.gov (United States)

    Cong, Z.; Kang, S.; Kawamura, K.; Liu, B.; Wan, X.; Wang, Z.; Gao, S.; Fu, P.

    2015-02-01

    To quantitatively evaluate the effect of carbonaceous aerosols on the south edge of the Tibetan Plateau, aerosol samples were collected weekly from August 2009 to July 2010 at Qomolangma (Mt. Everest) Station for Atmospheric and Environmental Observation and Research (QOMS, 28.36° N, 86.95° E, 4276 m a.s.l.). The average concentrations of organic carbon (OC), elemental carbon (EC) and water-soluble organic carbon were 1.43, 0.25 and 0.77 μg m-3, respectively. The concentration levels of OC and EC at QOMS are comparable to those at high-elevation sites on the southern slopes of the Himalayas (Langtang and Nepal Climate Observatory at Pyramid, or NCO-P), but 3 to 6 times lower than those at Manora Peak, India, and Godavari, Nepal. Sulfate was the most abundant anion species followed by nitrate, accounting for 25 and 12% of total ionic mass, respectively. Ca2+ was the most abundant cation species (annual average of 0.88 μg m-3). The dust loading, represented by Ca2+ concentration, was relatively constant throughout the year. OC, EC and other ionic species (NH4+, K+, NO3- and SO42-) exhibited a pronounced peak in the pre-monsoon period and a minimum in the monsoon season, being similar to the seasonal trends of aerosol composition reported previously from the southern slope of the Himalayas, such as Langtang and NCO-P. The strong correlation of OC and EC in QOMS aerosols with K+ and levoglucosan indicates that they mainly originated from biomass burning. The fire spots observed by MODIS and backward air-mass trajectories further demonstrate that in pre-monsoon season, agricultural and forest fires in northern India and Nepal were most likely sources of carbonaceous aerosol at QOMS. Moreover, the CALIOP observations confirmed that air-pollution plumes crossed the Himalayas during this period. The highly coherent variation of daily aerosol optical depth (500 nm) between QOMS and NCO-P indicates that both slopes of the Himalayas share a common atmospheric environment

  15. Asian Ice Core Array (AICA): Late Holocene Atmospheric Dust Reconstruction over Asia

    Science.gov (United States)

    Grigholm, B. O.; Mayewski, P. A.; Aizen, V. B.; Kang, S.; Aizen, E.; Kreutz, K. J.; Kaspari, S.; Fujita, K.; Takeuchi, N.; Wake, C. P.; Kurbatov, A.

    2010-12-01

    as well as consequences on regional socio-economics. Preliminary analysis suggests that atmospheric dust concentrations have generally declined at AICA sites in recent decades. Longer AICA records from the Himalayas (Everest) and central TP (Geladaindong) show generally opposite dust concentration trends over that last ~350 years and may be suggestive of regionally varying emission strength and/or atmospheric transport (e.g. westerly vs. monsoonal dominated circulation).

  16. The Preservation of "Non-Biological" Environments in the Solar System

    Science.gov (United States)

    Hargrove, Eugene

    Nature preservation will be a central element of the exploration of the Solar System, whether this emphasis is initially planned for or not. Exploration of extraterrestrial environments will generate images and scientific information that will excite the imagination of the general public throughout the world and be supportive of more funding for exploration. However, damage to the environments visited, once made public, will likely generate a backlash against exploration programs that could inhibit exploration or even bring it completely to an end. The exploration in the nineteenth century of the western United States, with landscapes aesthetically very different from those found in Europe but very similar to those existing on the Moon and on Mars, provides an excellent indication of what will happen in off-planet exploration. Nearly every place painted by a major artist or photographed by a photographer on a geological survey during that time period is today a national park or national monument. If extraterrestrial environments are not protected, the major space societies that are currently enthusiastically supportive of space agencies around the world could become political opponents, much as the Sierra Club evolved into a serious and effective critic of the U.S. Forest Service and National Park Service in the United States. At a minimum, space agencies must be protective of the historical landing sites on the Moon, avoid strip mining on the Moon that may draw criticism, and protect major features on Mars from damage, such as the Cydonian Face on Mars, Valles Marineris, the grand canyon of Mars, and Olympus Mons, a mountain three times as tall as Mount Everest. A good first step might be to establish a world-heritage-style site to protect the visible side of the Moon. Although extraterrestrial sites may initially be labeled "non-biological," caution must be taken to be protective of possible extraterrestrial life, active or dormant, even in the most unlikely

  17. XS-1 on ramp with B-29 mothership

    Science.gov (United States)

    1949-01-01

    XS-1 on the ramp with the B-29 mothership in 1949. This is the second XS-1 built; it later was converted into the X-1E. Unlike the XS-1-1, which was flown by the Air Force, the XS-1-2 was flown mostly by Bell and NACA pilots. It gathered much more research data than the more famous XS-1-1, known as 'Glamorous Glennis.' The first of the rocket-powered research aircraft, the X-1 (originally designated the XS-1), was a bullet-shaped airplane that was built by the Bell Aircraft Company for the US Air Force and the NACA. The mission of the X-1 was to investigate the transonic speed range (speeds from just below to just above the speed of sound) and, if possible, to break the 'sound barrier.' The first of the three X-1s was glide-tested at Pinecastle Army Air Field, FL, in early 1946. The first powered flight of the X-1 was made on Dec. 9, 1946, at Edwards Air Force Base with Chalmers Goodlin, a Bell test pilot, at the controls. On Oct. 14, 1947, with USAF Captain Charles 'Chuck' Yeager as pilot, the aircraft flew faster than the speed of sound for the first time. Captain Yeager ignited the four-chambered XLR-11 rocket engines after the B-29 air-launched it from under the bomb bay of a B-29 at 21,000 feet. The 6,000-pound thrust ethyl alcohol/liquid oxygen burning rockets, built by Reaction Motors, Inc., pushed the aircraft up to a speed of 700 miles per hour in level flight. Captain Yeager was also the pilot when the X-1 reached its maximum speed, 957 miles per hour. Another USAF pilot. Lt. Col. Frank Everest, Jr., was credited with taking the X-1 to its maximum altitude of 71,902 feet. Eighteen pilots in all flew the X-1s. The number three plane was destroyed in a fire before ever making any powered flights. A single-place monoplane, the X-1 was 30 feet, 11 inches long; 10 feet, 10 inches high; and had a wingspan of 29 feet. It weighed 6,784 pounds and carried 6,250 pounds of fuel. It had a flush cockpit with a side entrance and no ejection seat.

  18. The long-range transport of atmospheric aerosols from South Asia to Himalayas

    Science.gov (United States)

    Cong, Zhiyuan; Kang, Shichang; Kawamura, Kimitaka

    2016-04-01

    High levels of carbonaceous aerosol exist over South Asia, the area adjacent to the Himalayas and Tibetan Plateau. Little is known about if they can be transported across the Himalayas, and as far inland as the Tibetan Plateau. To resolve such scientific questions, aerosol samples were collected weekly from August 2009 to July 2010 at Qomolangma (Mt. Everest) Station for Atmospheric and Environmental Observation and Research(QOMS, 4276 m a.s.l.). In the laboratory, major ions, elemental carbon, organic carbon, levoglucosan, water-soluble organic carbon, and organic acids were analyzed. The concentration levels of OC and EC at QOMS are comparable to those at high-elevation sites on the southern slopes of the Himalayas (Langtang and NCO-P), but 3 to 6 times lower than those at Manora Peak, India, and Godavari, Nepal. Sulfate was the most abundant anion species followed by nitrate. The dust loading, represented by Ca2+ concentration, was relatively constant throughout the year. OC, EC and other ionic species (NH+4 , K+, NO‑ and SO2‑) exhibited a pronounced peak in the pre-monsoon period and a minimum in the monsoon season, being similar to the seasonal trends of aerosol compo-sition reported previously from the southern slope of the Himalayas. The strong correlation of OC and EC in QOMS aerosols with K+ and levoglucosan indicates that they mainly originated from biomass burning. Molecular distributions of dicarboxylic acids and related compounds (malonic acid/ succinic acid, maleic acid/fumaric acid) further support this finding. The fire spots observed by MODIS and backward air-mass trajectories further demonstrate that in pre-monsoon season, agricultural and forest fires in northern India and Nepal were most likely sources of carbonaceous aerosol at QOMS. In addition to large-scale atmospheric circulation, the unique mountain/valley breeze system can also have an important effect on air-pollutant transport.With the consideration of the darkening force of

  19. Chemical evidences of the effects of global change in high elevation lakes in Central Himalaya, Nepal

    Science.gov (United States)

    Tartari, Gianni; Lami, Andrea; Rogora, Michela; Salerno, Franco

    2016-04-01

    It is well known that the lakes integrate the pressure of their surrounding terrestrial environment and the climatic variability. Both the water column and sediments are capable to accumulate signals of global change, such as warming of the deep layers or mutation of diverse biological records (e.g., fossil diatoms) and the nutrient loads variability affecting the trophic state. Typically, the biological responses to climate change have been studied in several types of lakes, while documented changes in water chemistry are much rare. A long term study of 20 high altitude lakes located in central southern Himalaya (Mt Everest) conducted since the 90s has highlighted a general change in the chemical composition of the lake water: a substantial rise in the ionic content was observed, particularly pronounced in the case of sulphate. In a couple of these lakes, monitored on an annual basis, the sulphate concentrations increased over 4-fold. A change in the composition of atmospheric wet deposition, as well as a possible influence of decrease in seasonal snow cover duration, which could have exposed larger basin surfaces to alteration processes, were excluded. The chemical changes proved to be mainly related to the sulphide oxidation processes occurring in the bedrocks or the hydrographic basins. In particular, the oxidation processes, considered as the main factor causing the sulphate increase, occurred in subglacial environments characterized by higher glacier velocities causing higher glacier shrinkage. Associated to this mechanism, the exposure of fresh mineral surfaces to the atmosphere may have contributed also to increases in the alkalinity of lakes. Weakened monsoon of the past two decades may have partially contributed to the solute enrichment of the lakes through runoff waters. The almost synchronous response of the lakes studied, which differs in terms of the presence of glaciers in their basins, highlights the fact that the increasing ionic content of lake

  20. Intuitive ultrasonography for autonomous medical care in limited-resource environments

    Science.gov (United States)

    Dulchavsky, Scott A.; Sargsyan, Ashot E.; Garcia, Kathleen M.; Melton, Shannon L.; Ebert, Douglas; Hamilton, Douglas R.

    2011-05-01

    Management of health problems in limited resource environments, including spaceflight, faces challenges in both available equipment and personnel. The medical support for spaceflight outside Low Earth Orbit is still being defined; ultrasound (US) imaging is a candidate since trials on the International Space Station (ISS) prove that this highly informative modality performs very well in spaceflight. Considering existing estimates, authors find that US could be useful in most potential medical problems, as a powerful factor to mitigate risks and protect mission. Using outcome-oriented approach, an intuitive and adaptive US image catalog is being developed that can couple with just-in-time training methods already in use, to allow non-expert crew to autonomously acquire and interpret US data for research or diagnosis. The first objective of this work is to summarize the experience in providing imaging expertise from a central location in real time, enabling data collection by a minimally trained operator onsite. In previous investigations, just-in-time training was combined with real-time expert guidance to allow non-physician astronauts to perform over 80 h of complex US examinations on ISS, including abdominal, cardiovascular, ocular, musculoskeletal, dental/sinus, and thoracic exams. The analysis of these events shows that non-physician crew-members, after minimal training, can perform complex, quality US examinations. These training and guidance methods were also adapted for terrestrial use in professional sporting venues, the Olympic Games, and for austere locations including Mt. Everest. The second objective is to introduce a new imaging support system under development that is based on a digital catalog of existing sample images, complete with image recognition and acquisition logic and technique, and interactive multimedia reference tools, to guide and support autonomous acquisition, and possibly interpretation, of images without real-time link with a human

  1. To investigate the prevention and treatment of common complications of replacement therapy with pulmonary surfactant in neonates%新生儿肺表面活性物质替代疗法常见并发症的防治探讨

    Institute of Scientific and Technical Information of China (English)

    万忠和; 蓉容; 班奕

    2010-01-01

    Objective To investigate the clinical characteristic and prophylactic -therapeutic measures of common complications of pulmonary surfactant(PS) replacement therapy in neonates. Methods We analyzed the clinical data of 65 cases preterm neonates treated with PS replacement therapy in neonatal intensive care unit(NICU) of our hospital. Results In 65 cases,32 cases had one to five complications,totally 60 times. Those included 14 times pneumonia (21.5%), 10 times (15.4%)pneumorrhagia, 8times(12.3%) apnoea, intraventricular hemorrhage and bronchopulmonary dysplasia respectively 6 times(9.2%), patent ductus arteriosus, 3 times(4.6%), atelectasis and retinopathy of prematurity respectively 11 times(16.9%). 18 cases Of 32 xtremely low birth weight infants (56.3%) had different degree complications, and as that of 6 cases of 8 very low birth weight infants.54 cases after complex treatment were survival (survival rate 83.1%) and 11 cases died (mortality 16.9%). Conclusion Active precaution and early discovery and treatment all kinds of complications immediately could improve the effect of PS replacement therapy and reduce the mortality of the preterms.%目的 对新生儿肺表面活性物质(PS)替代疗法常见并发症的临床特点、诊断及其防治措施进行探讨.方法 对我院新生儿科重症监护病房(NICU)应用PS替代疗法的65例早产儿临床资料进行回顾性分析,分析PS替代治疗常见并发症的发生情况、临床特点、诊断、防治措施及其预后.结果 在65例应用PS的早产儿中,32例发生1~5种并发症,共60例次,其中肺炎14例(21.5%),肺出血10例(15.4%),呼吸暂停、脑室内出血(IVH)及支气管肺发育不良(BPD)各8例(12.3%),动脉导管未闭6例(9.2%),肺不张及早产儿视网膜病(ROP)各3例(4.6%).32例极低出生体重儿中,18例发生不同程度并发症(占56.3%):8例超低出生体重儿中,6例出现并发症(占75.0%).经综合治疗存活54例,存活率为83.1%.死亡11

  2. Storage-Intensive Supercomputing Benchmark Study

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, J; Dossa, D; Gokhale, M; Hysom, D; May, J; Pearce, R; Yoo, A

    2007-10-30

    : SuperMicro X7DBE Xeon Dual Socket Blackford Server Motherboard; 2 Intel Xeon Dual-Core 2.66 GHz processors; 1 GB DDR2 PC2-5300 RAM (2 x 512); 80GB Hard Drive (Seagate SATA II Barracuda). The Fusion board is presently capable of 4X in a PCIe slot. The image resampling benchmark was run on a dual Xeon workstation with NVIDIA graphics card (see Chapter 5 for full specification). An XtremeData Opteron+FPGA was used for the language classification application. We observed that these benchmarks are not uniformly I/O intensive. The only benchmark that showed greater that 50% of the time in I/O was the graph algorithm when it accessed data files over NFS. When local disk was used, the graph benchmark spent at most 40% of its time in I/O. The other benchmarks were CPU dominated. The image resampling benchmark and language classification showed order of magnitude speedup over software by using co-processor technology to offload the CPU-intensive kernels. Our experiments to date suggest that emerging hardware technologies offer significant benefit to boosting the performance of data-intensive algorithms. Using GPU and FPGA co-processors, we were able to improve performance by more than an order of magnitude on the benchmark algorithms, eliminating the processor bottleneck of CPU-bound tasks. Experiments with a prototype solid state nonvolative memory available today show 10X better throughput on random reads than disk, with a 2X speedup on a graph processing benchmark when compared to the use of local SATA disk.

  3. Computer modeling of Earthshine contamination on the VIIRS solar diffuser

    Science.gov (United States)

    Mills, Stephen P.; Agravante, Hiroshi; Hauss, Bruce; Klein, James E.; Weiss, Stephanie C.

    2005-10-01

    was causing higher than expected radiometric error, and asked whether VIIRS might have a similar problem. The NPOESS Models and Simulation (M&S) team considered whether the Lambertian BRDF assumption would cause an underestimating of the ESC error. Particularly, snow, ice and water show very large BRDFs for geometries for forward scattered, near-grazing angles of incidence, and in common parlance this is called glare. The observed earth geometry during the period where the SD is illuminated by the sun has just such geometries that produce strongly forward scattering glare. In addition the SD acquisition occurs in the polar regions, where snow, ice and water are most prevalent. Using models in their Environmental Products Verification and Remote Sensing Testbed (EVEREST), the M&S team produced a model that meticulously traced the light rays from the attenuation screen to each detector and combined this with a model of the satellite orbit, with solar geometry and radiative transfer models that include the effect of the BRDF of various surfaces. This modeling showed that radiometric errors up to 4.5% over water and 1.5% over snow or ice. Clouds produce errors up to 0.8%. The likelihood of these high errors occurring has not been determined. Because of this analysis, various remedial options are now being considered.

  4. Similarities and differences of aerosol optical properties between southern and northern slopes of the Himalayas

    Directory of Open Access Journals (Sweden)

    C. Xu

    2013-08-01

    Full Text Available The Himalayas is located at the southern edge of the Tibetan Plateau, and it acts as a natural barrier for the transport of atmospheric aerosols, e.g. from the polluted regions of South Asia to the main body of the Tibetan Plateau. In this study, we investigate the seasonal and diurnal variations of aerosol optical properties measured at the three Aerosol Robotic Network (AERONET sites over the southern (Pokhara station and EVK2-CNR station in Nepal and northern (Qomolangma (Mt. Everest station for Atmospheric and Environmental Observation and Research, Chinese Academy of Sciences (QOMS_CAS in Tibet, China slopes of the Himalayas. While observations at QOMS_CAS and EVK2-CNR can generally be representative of a remote background atmosphere, Pokhara is an urban site with much higher aerosol load due to the influence of local anthropogenic activities. The annual mean of aerosol optical depth (AOD during the investigated period was 0.06 at QOMS_CAS, 0.04 at EVK2-CNR and 0.51 at Pokhara, respectively. Seasonal variations of aerosols are profoundly affected by large scale atmospheric circulation. Vegetation fires, peaking during April in the Himalayan region and northern India, contribute to a growing fine mode AOD at 500 nm at the three stations. Dust transported to these sites results in an increase of coarse mode AOD during the monsoon season at the three sites. Meanwhile, coarse mode AOD at EVK2-CNR is higher than QOMS_CAS from July to September, indicating the Himalayas blocks the coarse particles carried by the southwest winds. The precipitation scavenging effect is obvious at Pokhara, which can significantly reduce the aerosol load during the monsoon season. Unlike the seasonal variations, diurnal variations are mainly influenced by meso-scale systems and local topography. In general, precipitation can lead to a decrease of the aerosol load and the average particle size at each station. AOD changes in a short time with the emission rate near

  5. 21st century Himalayan hydropower: Growing exposure to glacial lake outburst floods?

    Science.gov (United States)

    Schwanghart, Wolfgang; Worni, Raphael; Huggel, Christian; Stoffel, Markus; Korup, Oliver

    2014-05-01

    . Everest and Lulana regions of Nepal and Bhutan, respectively. Together with the dense, cascading sequence of hydropower stations along several river networks in these areas, the combination of GLOFs and artificial reservoirs in steep terrain may result in increasing threats to downstream communities. Hydropower stations are infrastructural investments with minimum design lives of several decades, and our results suggest that their planning should be orchestrated with projected changes in glacier response to future climate change. Our data underline the preponderance of glacial lakes in areas with high glacial retreat rates and a commensurate exposure of hydropower stations to GLOFs. To ensure sustainable water resources use at minimum risk implications for on-site downstream communities, potential changes in GLOF hazard should be taken seriously when planning hydropower stations in the Hindu Kush-Himalaya.

  6. The Jalisco Seismic Telemetric Network (RESJAL)

    Science.gov (United States)

    Nunez-Cornu, F. J.; Nunez-Cornu, F. J.; Reyes-Davila, G.; Reyes-Davila, G.; Suarez-Plascencia, C.; Suarez-Plascencia, C.; Gonzalez-Ledezma, M.; Garcia-Puga, J.

    2001-12-01

    The region of Jalisco is one of the most active seismic regions in Mexico, the main tectonic units in this region are the Jalisco Block and the Rivera Plate. The greatest earthquake (M=8.2) occurred in Mexico in the Twenty-Century (1932) took place in the coast of Jalisco, this was followed by another one (Ms =7.8) fifteen days later. In 1995 an earthquake magnitude 8.0 took place in the coast of Jalisco, but its rupture area was only the southern half of the rupture area proposed for the 1932 earthquakes, these facts suggest the existence of an important seismic Gap in the north coast of Jalisco which includes the area of Bahía de Banderas. However, not only subduction earthquakes occurred in this region there are also large inland earthquakes, such as the December 27, 1568 and February 11, 1872 events. There are also three active volcanoes Sanganguey, Ceboruco and the most active volcano in Mexico, the Colima volcano. In spite of these facts and the risk associated to these processes, there were only one seismological permanent station in Chamela on the coast of Jalisco and an analog telemetric network (RESCO) located on the Colima Volcano and the south part of the Colima Rift Zone (CRZ). By these reasons, the Unidad Estatal de Protección Civil de Jalisco (Jalisco Civil Defense) began a project to install a Digital Telemetric Network in the region in several phases, this project is carrying out jointly with SisVOc UdeG.; due to the size of the area and the topography of the region it is very difficult to get direct telemetric links, by these reasons the network is designed in cells with nodes, where the nodes are the different Campus of the University of Guadalajara located in the region, all Campus are linked by a computer network. First phase started in August 2001, it includes the installation of six stations, each station with a Kinemetrics Everest 24 bit datalogger, GPS time, and a Lennartz LE3Dlite 1Hz sensor, using KNI NMS to control and data acquisition

  7. 10-year record of atmospheric composition in the high Himalayas: source, transport and impact

    Science.gov (United States)

    Bonasoni, Paolo; Laj, Paolo; Marinoni, Angela; Cristofanelli, Paolo; Maione, Michela; Putero, Davide; Calzolari, Francescopiero; Decesari, Stefano; Facchini, Maria Cristina; Fuzzi, Sandro; Gobbi, Gianpaolo; Sellegri, Karine; Verza, Gianpietro; Vuillermoz, Elisa; Arduini, Jgor

    2016-04-01

    South Asia represents a global "hot-spot" for air-quality and climate impacts. Since the end of the 20th Century, field experiments and satellite observations identified a thick layer of atmospheric pollutants extending from the Indian Ocean up to the atmosphere of the Himalayas. Since large amount of short-lived climate pollutants (SLCPs) - like atmospheric aerosol (in particular, the light-absorbing aerosol) and ozone - characterize this region, severe implications were recognized for population health, ecosystem integrity as well as regional climate impacts, especially for what concerns hydrological cycle, monsoon regimes and cryosphere. Since 2006, the Nepal Climate Observatory - Pyramid (NCO-P, 27.95N, 86.82 E, 5079 m a.s.l.), a global station of the WMO/GAW programme has been active in the eastern Nepal Himalaya, not far from the Mt. Everest. NCO-P is located away from large direct anthropogenic pollution sources. The closest major urban area is Kathmandu (200 km south-west from the measurement site). As being located along the Khumbu valley, the observations are representative of synoptic-scale and mountain thermal circulation, providing direct information about the vertical transport of pollutants/climate-altering compounds to the Himalayas and to the free troposphere. In the framework of international programmes (GAW/WMO, UNEP-ABC, AERONET) the following continuous measurement programmes have been carried out at NCO-P: surface ozone, aerosol size distribution (from 10 nm to 25 micron), total particle number, aerosol scattering and absorption coefficients, equivalent BC, PM1-PM10, AOD by sun-photometry, global solar radiation (SW and LW), meteorology. Long-term sampling programmes for the off-line determination of halogenated gases and aerosol chemistry have been also activated. The atmospheric observation records at NCO-P, now representing the longest time series available for the high Himalayas, provided the first direct evidences about the systematic

  8. Addressing capability computing challenges of high-resolution global climate modelling at the Oak Ridge Leadership Computing Facility

    Science.gov (United States)

    Anantharaj, Valentine; Norman, Matthew; Evans, Katherine; Taylor, Mark; Worley, Patrick; Hack, James; Mayer, Benjamin

    2014-05-01

    ,640 equivalent cores. Scientific applications, such as CESM, are also required to demonstrate a "computational readiness capability" to efficiently scale across and utilize 20% of the entire system. The 0,25 deg configuration of the spectral element dynamical core of the Community Atmosphere Model (CAM-SE), the atmospheric component of CESM, has been demonstrated to scale efficiently across more than 5,000 nodes (80,000 CPU cores) on Titan. The tracer transport routines of CAM-SE have also been ported to take advantage of the hybrid many-core architecture of Titan using GPUs [see EGU2014-4233], yielding over 2X speedup when transporting over 100 tracers. The high throughput I/O in CESM, based on the Parallel IO Library (PIO), is being further augmented to support even higher resolutions and enhance resiliency. The application performance of the individual runs are archived in a database and routinely analyzed to identify and rectify performance degradation during the course of the experiments. The various resources available at the OLCF now support a scientific workflow to facilitate high-resolution climate modelling. A high-speed center-wide parallel file system, called ATLAS, capable of 1 TB/s, is available on Titan as well as on the clusters used for analysis (Rhea) and visualization (Lens/EVEREST). Long-term archive is facilitated by the HPSS storage system. The Earth System Grid (ESG), featuring search & discovery, is also used to deliver data. The end-to-end workflow allows OLCF users to efficiently share data and publish results in a timely manner.

  9. Lithosphere, crust and basement ridges across Ganga and Indus basins and seismicity along the Himalayan front, India and Western Fold Belt, Pakistan

    Science.gov (United States)

    Ravi Kumar, M.; Mishra, D. C.; Singh, B.

    2013-10-01

    Himalaya in the Kangra reentrant where the great Kangra earthquake of 1905 was located. (ii) The Aravalli Delhi Mobile Belt (ADMB) and its margin faults extend to the Western Himalayan front via Delhi where it interacts with the Delhi-Lahore ridge and further north with the Himalayan front causing seismic activity. (iii) The Shahjahanpur and Faizabad ridges strike the Himalayan front in Central Nepal that do not show any enhanced seismicity which may be due to their being parts of the Bundelkhand craton as simple basement highs. (iv) The west and the east Patna faults are parts of transcontinental lineaments, such as Narmada-Son lineament. (v) The Munghyr-Saharsa ridge is fault controlled and interacts with the Himalayan front in the Eastern Nepal where Bihar-Nepal earthquakes of 1934 has been reported. Some of these faults/lineaments of the Indian continent find reflection in seismogenic lineaments of Himalaya like Everest, Arun, Kanchenjunga lineaments. A set of NW-SE oriented gravity highs along the Himalayan front and the Ganga and the Indus basins represents the folding of the basement due to compression as anticlines caused by collision of the Indian and the Asian plates. This study has also delineated several depressions like Saharanpur, Patna, and Purnia depressions.

  10. Imaging Water in Deformed Quartzites: Examples from Caledonian and Himalayan Shear Zones

    Science.gov (United States)

    Kronenberg, Andreas; Ashley, Kyle; Hasnan, Hasnor; Holyoke, Caleb; Jezek, Lynna; Law, Richard; Thomas, Jay

    2016-04-01

    Infrared IR measurements of OH absorption bands due to water in deformed quartz grains have been collected from major shear zones of the Caledonian and Himalayan orogens. Mean intragranular water contents were determined from the magnitude of the broad OH absorption at 3400 cm‑1 as a function of structural position, averaging over multiple grains, using an IR microscope coupled to a conventional FTIR spectrometer with apertures of 50-100 μm. Images of water content were generated by scanning areas of up to 4 mm2 of individual specimens with a 10 μm synchrotron-generated IR beam and contouring OH absorptions. Water contents vary with structural level relative to the central cores of shear zones and they vary at the grain scale corresponding to deformation and recrystallization microstructures. Gradients in quartz water content expressed over structural distances of 10 to 400 m from the centers of the Moine Thrust (Stack of Glencoul, NW Scotland), the Main Central Thrust (Sutlej valley of NW India), and the South Tibetan Detachment System (Rongbuk valley north of Mount Everest) indicate that these shear zones functioned as fluid conduits. However, the gradients differ substantially: in some cases, enhanced fluid fluxes appear to have increased quartz water contents, while in others, they served to decrease water contents. Water contents of Moine thrust quartzites appear to have been reduced during shear at greenschist facies by processes of regime II BLG/SGR dislocation creep. Intragranular water contents of the protolith 70 m below the central fault core are large (4078 ± 247 ppm, H/106 Si) while mylonites within 5 mm of the Moine hanging wall rocks have water contents of only 1570 (± 229) ppm. Water contents between these extremes vary systematically with structural level and correlate inversely with the extent of dynamic recrystallization (20 to 100%). Quartz intragranular water contents of Himalayan thrust and low-angle detachment zones sheared at upper

  11. Provenance of the Indus-Yarlung Suture Mélange and the Location of the India-Asia Suture, Southern Tibet

    Science.gov (United States)

    Metcalf, K.; Kapp, P. A.; Orme, D. A.; Laskowski, A. K.

    2013-12-01

    The Indus-Yarlung Suture Zone (IYSZ) is the boundary between rocks of Indian and Asian affinity. From north to south in southern Tibet, it exposes the preserved Asian forearc, ophiolitic rocks, tectonic mélanges, and Tethyan Himalayan strata of Indian affinity. The mélange has long been considered the accretionary prism corresponding to the ophiolite to the north which obducted onto the Indian margin prior to India-Asia collision. An outstanding issue is whether the ophiolitic rocks and mélanges were (1) obducted onto the northern margin of India or (2) associated with the Cordilleran-style southern margin of Asia, prior to India - Asia collision. Resolving this issue is fundamental to understanding the precollisional tectonic framework of the Neo-Tethyan realm, interpreting the timing of initial continental collision from detrital records, and locating the suture. We conducted geologic mapping and U/Pb detrital zircon provenance studies of the blocks and matrix of the mélanges and of Tethyan Himalayan units to the south at two localities: near Lhatse, which is ~140 km north of Mt. Everest and near Lopu Kangri, ~300 km along strike to the west. Near Lhatse the mélange is composed of a mudstone matrix with blocks of basalt, chert, mudstone, metabasite, limestone, and sandstone. The majority of the blocks are deep-water facies or consistent with oceanic crust, supporting the interpretation that the mélange is an accretionary complex formed by oceanic subduction. A south-dipping fault ~9 km north of Lhatse separates the mélange to the north from a continuous sequence of sandstone, shale, and minor limestone to the south. Previous work along strike suggests that this sequence, which has been previously identified as Tethyan affinity, contains Asian affinity detrital zircon populations. Near Lopu Kangri, the mélange is similar to that exposed in Lhatse. Over a distance of ~10 km to the southwest, blocks gradually increase in size to encompass ~2 km x ~10 km

  12. Atmospheric aerosol brown carbon in the high Himalayas

    Science.gov (United States)

    Kirillova, Elena; Decesari, Stefano; Marinoni, Angela; Bonasoni, Paolo; Vuillermoz, Elisa; Facchini, M. Cristina; Fuzzi, Sandro

    2016-04-01

    Anthropogenic light-absorbing atmospheric aerosol can reach very high concentrations in the planetary boundary layer in South-East Asia ("brown clouds"), affecting atmospheric transparency and generating spatial gradients of temperature over land with a possible impact on atmospheric dynamics and monsoon circulation. Besides black carbon (BC), an important light-absorbing component of anthropogenic aerosols is the organic carbon component known as 'brown carbon' (BrC). In this research, we provided first measurements of atmospheric aerosol BrC in the high Himalayas during different seasons. Aerosol sampling was conducted at the GAW-WMO Global station "Nepal Climate Observatory-Pyramid" (NCO-P) located in the high Khumbu valley at 5079 m a.s.l. in the foothills of Mt. Everest. PM10 aerosol samples were collected from July 2013 to November 2014. The sampling strategy was set up in order to discriminate the daytime valley breeze bringing polluted air masses up to the observatory and free tropospheric air during nighttime. Water-soluble BrC (WS-BrC) and methanol-soluble BrC (MeS-BrC) were extracted and analyzed using a UV/VIS spectrophotometer equipped with a 50 cm liquid waveguide capillary cell. In the polluted air masses, the highest levels of the BrC light absorption coefficient at 365 nm (babs365) were observed during the pre-monsoon season (1.83±1.46 Mm-1 for WS-BrC and 2.86±2.49 Mm-1 for MeS-BrC) and the lowest during the monsoon season (0.21±0.22 Mm-1 for WS-BrC and 0.32±0.29 Mm-1 for MeS-BrC). The pre-monsoon season is the most frequently influenced by a strong atmospheric brown cloud (ABC) transport to NCO-P due to increased convection and mixing layer height over South Asia combined with the highest up-valley wind speed and the increase of the emissions from open fires due to the agricultural practice along the Himalayas foothills and the Indo-Gangetic Plain. In contrast, the monsoon season is characterized by a weakened valley wind regime and an

  13. Star Formation in Henize 206

    Science.gov (United States)

    2004-01-01

    from that explosion impacted a cloud of nearby hydrogen gas, compressed it, and started a new generation of star formation. The death of one star led to the birth of many new stars. This is particularly evident in the MIPS inset, where the 24-micron emission peaks correspond to newly formed stars. The ultraviolet and visible-light photons from the new stars are absorbed by surrounding dust and re-radiated at longer infrared wavelengths, where it is detected by Spitzer. This emission nebula was cataloged by Karl Henize (HEN-eyes) while spending 1948-1951 in South Africa doing research for his Ph.D. dissertation at the University of Michigan. Henize later became a NASA astronaut and, at age 59, became the oldest rookie to fly on the Space Shuttle during an eight-day flight of the Challenger in 1985. He died just short of his 67th birthday in 1993 while attempting to climb the north face of Mount Everest, the world's highest peak.

  14. The challenges of catchment hydrological modelling in the Himalayan region: a case study from the Dudh Kosi River basin of Eastern Nepal

    Science.gov (United States)

    Nepal, Santosh; Bajracharya, Sagar R.; Shea, Joseph; Wahid, Shahriar M.; Shrestha, Arun B.; Flügel, Wolfgang-Albert

    2014-05-01

    Catchment-scale hydrological modelling in the Himalayan region suffers from multiple issues that affect our ability to represent the hydrological dynamics of a river system. Due to a lack of monitoring infrastructure, especially in the high-altitude areas, the spatial distribution of precipitation is essentially unknown. Therefore, the regionalization of precipitation in river basins is a challenging task that has implications in the modelling approach at different levels. This paper explores the uncertainty in modelled discharge using different precipitation input datasets in the glaciated catchment of the Dudh Kosi River basin in Eastern Nepal (3712 km2). The basin hosts some of the world's highest mountain peaks, including Mt Everest. Six precipitation stations, which cover mostly the lowland area of the basin, give a station density of one station per 618 km2. First, we examine precipitation dynamics in the study area based on the observed data. Second, the process-oriented distributed J2000 hydrological model is applied in the Dudh Kosi River basin. Third, the model is run with APHRODITE-(V1003R1), CPC-RFE-(2.0) and TRMM-(V7) precipitation products to compare observed and modelled discharge. Nearly 82% of the precipitation occurs during the monsoon season (June - September), and the limited station observations suggest that there is non-uniform distribution of precipitation in which the underlying topography has a great influence. The maximum precipitation occurred at the station which is located on the middle hills region, followed by the station located at the foothills of the Higher Himalaya. Compared to the observed precipitation, the TRMM product is found to be 7% less than the observed data, whereas the other two products were up to 35% less. The model was applied with the six stations data and the regionalization was carried out using Inverse Distance Weighting (IDW) method to simulate the hydrograph. The model was first applied between 1985-1997 in

  15. miR-155对含SH2区域的肌醇5’磷酸酶1转录后调控在急性髓系白血病发病机制中作用的初步研究%Preliminary study of role of post-transcription regulation on SH2 domain-containing inositol 5'-phosphatase 1 gene expression by miR-155 in the pathogenesis of acute myeloid leukemia

    Institute of Scientific and Technical Information of China (English)

    薛华; 赵松颖; 王静; 范丽霞; 化罗明; 罗建民

    2015-01-01

    目的 探讨miR-155对人类含SH2区域的肌醇5’磷酸酶1(SHIP1)的转录后调控在急性髓系白血病(AML)发病机制中的作用.方法 应用反转录聚合酶链反应(RT-PCR)法检测30例AML患者miR-155、SHIP1的mRNA表达水平,选取同年龄健康人骨髓为对照组.人白血病U937细胞转染miR-155类似物后,RT-PCR法检测转染细胞中miR-155、SHIP1的mRNA表达水平.Western blot法检测转染后细胞SHIP1、AKT、pAKT蛋白水平.流式细胞术检测转染后细胞凋亡的变化.结果 30例AML患者中,15例AML-M4及AML-M5患者SHIP1蛋白水平较非AML-M4及AML-M5患者明显降低,而miR-155表达水平相应升高(均P< 0.05).U937细胞转染miR-155后,SHIP1蛋白水平较转染阴性对照组降低(P<0.05),而p-AKT水平较转染阴性对照组明显升高,转染后细胞凋亡明显受抑(P<0.05).结论 miR-155可对SHIP1进行转录后调控,miR-155可能通过降低SHIP1活性而激活PI3K-AKT途径,抑制白血病细胞的凋亡,从而促进AML的发生.%Objective To investigate the role of microRNA-155 (miR-155) on post-transcription regulation of SH2 domain-containing inositol 5'-phosphatase 1 (SHIP1) gene expression in the pathogenesis of acute myeloid leukemia (AML).Methods Quantitative real-time polymerase chain reaction (RT-PCR) was performed to detect the expression of miR-155 and SHIP1 mRNA in the AML patients and controls.miR-155 mimics was transfected into U937cells (U937m) by using X-treme GENE siRNA transfection reagent.Cells without transfection (U937c) and cells with negative transfection (U937mc) were used as controls.RT-PCR was performed to detect the expression of miR-155 and SHIP1 mRNA in these cells.The expression of SHIP1,TAKT and pAKT were detected by Western blot in U937 cells.Apoptosis was studied by flow cytometry (FCM).Results The average level of SHIP1 protein content in 15 samples of patients with AML-M4 or AML-M5 from 30 AML patients was significantly lower compared with that of

  16. EDITORIAL: Extreme Ultraviolet Light Sources for Semiconductor Manufacturing

    Science.gov (United States)

    Attwood, David

    2004-12-01

    filaments, for both Xe and Sn. The embodiment of electrical discharge plasmas and laser-produced plasmas into commercially available EUV sources, with EUV powers that project to suitable levels, is presented in the fifth paper by Uwe Stamm of XTREME Technologies in Göttingen. For discharge produced plasmas, thermal loading and electrode erosion are significant issues. Vladimir Borisov and his colleagues, at the Troitsk Institute outside Moscow, address these issues and provide novel ideas for the multiplexing of several discharge plasmas feeding a single optical system. Igor Fomenkov and his colleagues at Cymer in San Diego describe issues associated with a dense plasma focus pinch, including a comparison of operations with both positive and negative polarity. In the eighth paper, Malcolm McGeoch of Plex in Massachusetts provides a theoretical description of the vaporization and ionization of spherical tin droplets in discharge plasma. Together this cluster of papers provides a broad review of the current status of high power EUV plasma sources for semiconductor manufacturing. This very current topic, of intense interest worldwide, is considered further in a book [4] of collected papers to become available in mid-2005. Additionally, a special journal issue emphasizing coherent EUV sources, albeit at lower average powers, is soon to appear [5]. References [1] http://public.itrsr.net [2] Attwood D 2000 Soft X-Rays and Extreme Ultraviolet Radiation: Principles and Applications (Cambridge: Cambridge University Press) www.coe.Berkeley.edu/AST/sxreuv [3] Moore G E 1965 Cramming More Components onto Integrated Circuits Electronics Magazine 114 Moore G E 1995 Lithography and the Future of Moore's Law SPIE 243 2 [4] Bakshi V ed 2005 EUV Sources for Lithography (Bellingham WA:SPIE) at press [5] IEEE J. Special Topics in Quantum Electronics, Short Wavelength and EUV Lasers 10 Dec 2004 at press

  17. Spatial variation law of the extreme value position of analytical signal amplitude for potential field data%位场解析信号振幅极值位置空间变化规律研究

    Institute of Scientific and Technical Information of China (English)

    王万银

    2012-01-01

    In this paper, the extreme value position and their spatial variation rules of analytic signal amplitude of gravity anomaly and gravity anomaly vertical derivative were analyzed by the means of single-border, double-border, multi-borders and point (or line) quality models. The research results indicated thai the analytic signal amplitude of gravity anomaly vertical derivative have the same extreme value position as that of the RTP magnetic anamoly, and have the similar spatial variation rules as that of gravity anomaly. We can accurately recognize edge location of the single-border vertical body by the means of the maximum value position, but can not accurately recognize to any other geological bodies, and the offset varies with the buried depth, horizontal dimension and the degree of inclination of the geological bodies. Although the analytic signal amplitude of gravity anomaly vertical derivative has even more incisive peak than that of gravity anomaly, has more powerful crosswise recognition capability, and the extreme value position is nearer to the top edge of the geological body, but both influenced by the buried depth of the geological body; With increasing of the buried depth, the i-xtreme value position of the potential field analytic signal amplitude converges fast to the central location of the geological body, and the orbit is similar to fork shape; And for the multi-border model, we can not recognize edge location of the body because of the blind spot of the maximum location of analytic signal amplitude. The above theories researches show that the analytic signal amplitude of potential field is suitable for recognize the edges location of the single-border geological body only, and should not be used to recognize the edge location of the multi-borders geological body, but can be used to recognize the central location of the multi-borders geological body.%通过对单一边界、双边界、多边界以及点(线)质量模型重力异常解析信号振

  18. Atmospheric Brown Clouds in the Himalayas: first two years of continuous observations at the Nepal-Climate Observatory at Pyramid (5079 m

    Directory of Open Access Journals (Sweden)

    P. Bonasoni

    2010-02-01

    Full Text Available South Asia is strongly influenced by the so-called Atmospheric Brown Cloud (ABC, a wide polluted layer extending from the Indian Ocean to the Himalayas during the winter and pre-monsoon seasons (November to April. This thick, grey-brown haze blanket substantially interacts with the incoming solar radiation, causing a cooling of the Earth's surface and a warming of the atmosphere, thus influencing the monsoon system and climate. In this area, the Himalayan region, particularly sensitive to climate change, offers a unique opportunity to detect global change processes and to analyse the influence of anthropogenic pollution on background atmospheric conditions through continuous monitoring activities.

    This paper provides a detailed description of the atmospheric conditions characterizing the high Himalayas, thanks to continuous observations begun in March 2006 at the Nepal Climate Observatory – Pyramid (NCO-P located at 5079 m a.s.l. on the southern foothills of Mt. Everest, in the framework of ABC-UNEP and SHARE-Ev-K2-CNR projects. Besides giving an overview of the measurement site and experimental activities, the work presents an in-depth characterization of meteorological conditions and air-mass circulation at NCO-P during the first two years of activity (March 2006–February 2008. The mean values of atmospheric pressure, temperature and wind speed recorded at the site were: 551 hPa, −3.0 °C, 4.7 m s−1, respectively. The highest seasonal values of temperature (1.7 °C and relative humidity (94% were registered during the monsoon season, which was also characterized by thick clouds present in about 80% of the afternoon hours and by a frequency of cloud-free sky less than 10%. The lowest temperature and relative humidity values were registered during winter, −6.3 °C and 22%, respectively, the season being characterised by mainly cloud-free sky conditions and rare thick clouds. The summer monsoon influenced

  19. 青藏高原冰川区可溶性有机碳含量和来源研究%Concentration and Source of Dissolved Organic Carbon in Snowpits of the Tibetan Plateau

    Institute of Scientific and Technical Information of China (English)

    严芳萍; 康世昌; 陈鹏飞; 柏建坤; 李洋; 胡召富; 李潮流

    2015-01-01

    Snowpit samples of three glaciers ( Laohugou NO. 12 Glacier ( LHG), Small Dongkemadi Glacier on Mount Tanggula (TGL) and East Rongbuk Glacier on Mount Everest (ZF)) in the Tibetan Plateau were collected. Concentrations of DOC and major ions were analyzed. The results showed that average DOC concentrations of the snowpits of LHG, TGL and ZF were (250. 30 ± 157. 10), (216. 92 ± 142. 82) and (152. 50 ± 56. 11) μg·L - 1 , respectively. DOC of TGL and ZF accounted for large parts of total values of DOC and ions. Correspondingly, DOC of LHG accounted for small part (only 5% ), because LHG was located at north China and intensively influenced by natural mineral dust, which caused high concentrations of Ca2 + (the highest value could reach 5 299. 18μg·L - 1 ) and consequently low percentage of DOC of snowpit samples. Correlation and PCA analyses were used to study the sources of DOC. DOC was significantly correlated with Ca2 + , Mg2 + , K + and SO2 -4 . Additionally, PCA further indicated that the main potential source of DOC was the natural source of mineral dust. Meanwhile, anthropogenic pollutants ( e. g. biomass, fossil combustion and agricultural related pollutants) could also not be ignored. Moreover, the carbon depositional fluxes of three snowpits were roughly estimated, and the values of LHG, TGL and ZF snowpits were 189. 23, 132. 76 and 128. 44 mg·(m2·a) - 1 , respectively, which played a significant role in the carbon cycle in this region and was also helpful for the study of glaciers fluctuation.%对青藏高原祁连山老虎沟12号冰川、唐古拉山小冬克玛底冰川及珠穆朗玛峰北坡东绒布冰川雪坑样品中可溶性有机碳(DOC)和主要离子的质量浓度进行了分析.结果表明3个雪坑中 DOC 的平均质量浓度分别为(250.30±157.10)、(216.92±142.82)和(152.50±56.11)μg·L -1,具有从北到南依次减小的空间分布特点.3个雪坑 DOC 和主要离子质量浓度比例分析表明,唐古拉山冰川区和

  20. SRTM Data Release for Eurasia, Index Map and Colored Height

    Science.gov (United States)

    2004-01-01

    The colored regions of this map show the extent of digital elevation data recently released by the Shuttle Radar Topography Mission (SRTM). This release includes data for most of Europe and Asia plus numerous islands in the Indian and Pacific Oceans. SRTM flew on board the Space Shuttle Endeavour in February 2000 and used an interferometric radar system to map the topography of Earth's landmass between latitudes 56 degrees south and 60 degrees north.The data were processed into geographic 'tiles,' each of which represents one by one degree of latitude and longitude. A degree of latitude measures 111 kilometers (69 miles) north-south, and a degree of longitude measures 111 kilometers or less east-west, decreasing away from the equator. The data are being released to the public on a continent-by-continent basis. This Eurasia segment includes 5,940 tiles, more than a third of the total data set. Previous releases covered North America and South America. Forthcoming releases will include Africa-Arabia and Australia plus an 'Islands' release for those islands not included in the continental releases. Together these data releases constitute the world's first high-resolution, near-global elevation model. The resolution of the publicly released data is three arcseconds (1/1,200 of a degree of latitude and longitude), which is about 90 meters (295 feet).European coverage in the current data release stretches eastward from the British Isles and the Iberian Peninsula in the west, across the Alps and Carpathian Mountains, as well as the Northern European Plain, to the Ural and Caucasus Mountains bordering Asia. The Asian coverage includes a great diversity of landforms, including the Tibetan Plateau, Tarin Basin, Mongolian Plateau, and the mountains surrounding Lake Baikal, the world's deepest lake. Mt. Everest in the Himalayas, at 8,848 meters (29,029 feet) is the world's highest mountain. From India's Deccan Plateau, to Southeast Asia, coastal China, and Korea, various

  1. Proceedings of the 6. conference days on radioprotection optimization in the nuclear, industrial and medical domains

    International Nuclear Information System (INIS)

    This 6. ALARA conference was jointly organised by the French Society of Radiation Protection (SFRP) and several professional associations (ABR, AFPPE, ARRAD, ATSR, RAMIP, SFPM, SFR). The conference was the occasion to review all aspects relative to the issues of radioprotection optimization and to its implementation to workers, patients and the public in the nuclear, industrial and medical domains. A particular attention must be given to the application of the ALARA principle in all sectors relevant to radioprotection, especially in a context characterized by: big dismantling works under preparation in the French nuclear park, an increased use of X-radiation in the medical domain - involving both patients and medical personnel, new knowledge concerning the health effects of ionizing radiations, and an evolution of European and international radioprotection safety standards. All these aspects were discussed during these conference days. This document brings together the available presentations (slides) together with their corresponding abstracts (in French) and dealing with: 1 - Review of the evolution of workers/patients exposure in France and comparison with international data (E. Vial); 2 - Status of low dose epidemiology (M.O. Bernier); 3 - Radioprotection optimization method at the MELOX plant (A. De Vita); 4 - Elaboration method for the annual dosimetric objective of the French nuclear park (C. Pignot); 5 - Optimisation principle in the new EURATOM Directive (N. Saad); 6 - Integrated management of radiological and non-radiological risks: the inevitable challenge (P. Deboodt); 7 - Radiological and conventional risks: the French Atomic Energy Commission (CEA) integrated approach (S. Faure); 8 - EVEREST (Evolving towards an entry into controlled areas in street clothes, M. Alvarez); 9 - Example of multi-risk management in the medical domain (C. Tourneux); 10 - Radioprotection optimisation in the research domain (P. Barbey); 11 - Child scanning dosimetry

  2. Atmospheric Brown Clouds in the Himalayas: first two years of continuous observations at the Nepal Climate Observatory-Pyramid (5079 m

    Directory of Open Access Journals (Sweden)

    P. Bonasoni

    2010-08-01

    Full Text Available This paper provides a detailed description of the atmospheric conditions characterizing the high Himalayas, thanks to continuous observations begun in March 2006 at the Nepal Climate Observatory-Pyramid (NCO-P located at 5079 m a.s.l. on the southern foothills of Mt. Everest, in the framework of ABC-UNEP and SHARE-Ev-K2-CNR projects. The work presents a characterization of meteorological conditions and air-mass circulation at NCO-P during the first two years of activity. The mean values of atmospheric pressure, temperature and wind speed recorded at the site were: 551 hPa, −3.0 °C, 4.7 m s−1, respectively. The highest seasonal values of temperature (1.7 °C and relative humidity (94% were registered during the monsoon season, which was also characterized by thick clouds, present in about 80% of the afternoon hours, and by a frequency of cloud-free sky of less than 10%. The lowest temperature and relative humidity seasonal values were registered during winter, −6.3 °C and 22%, respectively, the season being characterised by mainly cloud-free sky conditions and rare thick clouds. The summer monsoon influenced rain precipitation (seasonal mean: 237 mm, while wind was dominated by flows from the bottom of the valley (S–SW and upper mountain (N–NE.

    The atmospheric composition at NCO-P has been studied thanks to measurements of black carbon (BC, aerosol scattering coefficient, PM1, coarse particles and ozone. The annual behaviour of the measured parameters shows the highest seasonal values during the pre-monsoon (BC: 316.9 ng m−3, PM1: 3.9 μg m−3, scattering coefficient: 11.9 Mm−1, coarse particles: 0.37 cm−3 and O3: 60.9 ppbv, while the lowest concentrations occurred during the monsoon (BC: 49.6 ng m−3, PM1: 0.6 μg m−3, scattering coefficient: 2.2 Mm−1, and O3: 38.9 ppbv

  3. Final master work plan : environmental investigations at former CCC/USDA facilities in Kansas, 2002 revision.

    Energy Technology Data Exchange (ETDEWEB)

    Burton, J. C.; Environmental Research

    2003-01-23

    The Commodity Credit Corporation (CCC) of the U.S. Department of Agriculture (USDA) has entered into an interagency agreement with the U.S. Department of Energy (DOE) under which Argonne National Laboratory provides technical assistance for hazardous waste site characterization and remediation for the CCC/USDA. Carbon tetrachloride is the contaminant of primary concern at sites in Kansas where former CCC/USDA grain storage facilities were located. Argonne applies its QuickSite(reg sign) Expedited Site Characterization (ESC) approach to these former facilities. The QuickSite environmental site characterization methodology is Argonne's proprietary implementation of the ESC process (ASTM 1998). Argonne has used this approach at several former CCC/USDA facilities in Kansas, including Agenda, Agra, Everest, and Frankfort. The Argonne ESC approach revolves around a multidisciplinary, team-oriented approach to problem solving. The basic features and steps of the QuickSite methodology are as follows: (1) A team of scientists with diverse expertise and strong field experience is required to make the process work. The Argonne team is composed of geologists, geochemists, geophysicists, hydrogeologists, chemists, biologists, engineers, computer scientists, health and safety personnel, and regulatory staff, as well as technical support staff. Most of the staff scientists are at the Ph.D. level; each has on average, more than 15 years of experience. The technical team works together throughout the process. In other words, the team that plans the program also implements the program in the field and writes the reports. More experienced scientists do not remain in the office while individuals with lesser degrees or experience carry out the field work. (2) The technical team reviews, evaluates, and interprets existing data for the site and the contaminants there to determine which data sets are technically valid and can be used in initially designing the field program. A basic

  4. Glaciers of Asia

    Science.gov (United States)

    Williams, Richard S., Jr.; Ferrigno, Jane G.

    2010-01-01

    -glacier systems of the world including the Himalaya, Karakorum, Tien Shan and Altay mountain ranges. The glaciers are widely scattered and cover an area of about 59,425 km2. The mountain glaciers may be classified as maritime, subcontinental or extreme continental. In Afghanistan, more than 3,000 small glaciers occur in the Hindu Kush and Pamir mountains. Most glaciers occur on north-facing slopes shaded by mountain peaks and on east and southeast slopes that are shaded by monsoon clouds. The glaciers provide vital water resources to the region and cover an area of about 2,700 km2. Glaciers of northern Pakistan are some of the largest and longest mid-latitude glaciers on Earth. They are located in the Hindu Kush, Himalaya, and Karakoram mountains and cover an area of about 15,000 km2. Glaciers here are important for their role in providing water resources and their hazard potential. The glaciers in India are located in the Himalaya and cover about 8,500 km2. The Himalaya contains one of the largest reservoirs of snow and ice outside the polar regions. The glaciers are a major source of fresh water and supply meltwater to all the rivers in northern India, thereby affecting the quality of life of millions of people. In Nepal, the glaciers are located in the Himalaya as individual glaciers; the glacierized area covers about 5,324 km2. The region is the highest mountainous region on Earth and includes the Mt. Everest region. Glaciers in the Bhutan Himalaya have a total area of about 1,317 km2. Many recent glacier studies are focused on glacier lakes that have the potential of generating dangerous glacier lake outburst floods. Research on the glaciers of the middle-latitude, high-mountain glaciers of Asia has also focused on the information contained in the ice cores from the glaciers. This information helps in the reconstruction of paleoclimatic records, and the computer modeling of global climate change.

  5. SRTM Data Release for Eurasia, Index Map and Colored Height

    Science.gov (United States)

    2004-01-01

    The colored regions of this map show the extent of digital elevation data recently released by the Shuttle Radar Topography Mission (SRTM). This release includes data for most of Europe and Asia plus numerous islands in the Indian and Pacific Oceans. SRTM flew on board the Space Shuttle Endeavour in February 2000 and used an interferometric radar system to map the topography of Earth's landmass between latitudes 56 degrees south and 60 degrees north.The data were processed into geographic 'tiles,' each of which represents one by one degree of latitude and longitude. A degree of latitude measures 111 kilometers (69 miles) north-south, and a degree of longitude measures 111 kilometers or less east-west, decreasing away from the equator. The data are being released to the public on a continent-by-continent basis. This Eurasia segment includes 5,940 tiles, more than a third of the total data set. Previous releases covered North America and South America. Forthcoming releases will include Africa-Arabia and Australia plus an 'Islands' release for those islands not included in the continental releases. Together these data releases constitute the world's first high-resolution, near-global elevation model. The resolution of the publicly released data is three arcseconds (1/1,200 of a degree of latitude and longitude), which is about 90 meters (295 feet).European coverage in the current data release stretches eastward from the British Isles and the Iberian Peninsula in the west, across the Alps and Carpathian Mountains, as well as the Northern European Plain, to the Ural and Caucasus Mountains bordering Asia. The Asian coverage includes a great diversity of landforms, including the Tibetan Plateau, Tarin Basin, Mongolian Plateau, and the mountains surrounding Lake Baikal, the world's deepest lake. Mt. Everest in the Himalayas, at 8,848 meters (29,029 feet) is the world's highest mountain. From India's Deccan Plateau, to Southeast Asia, coastal China, and Korea, various