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Sample records for carolina autopsy series

  1. A case series of clinically undiagnosed hematopoietic neoplasms discovered at autopsy.

    Science.gov (United States)

    Podduturi, Varsha; Guileyardo, Joseph M; Soto, Luis R; Krause, John R

    2015-06-01

    In the United States, autopsy rates have diminished to less than 5% during the last half of the 20th century and the beginning of the 21st century for a multitude of reasons. Many believe this results in unrecognized malignancies that could have explained a patient's death. We describe six deaths in which hematopoietic neoplasms were identified at autopsy but were not diagnosed clinically. The six undiagnosed hematopoietic malignancy cases discovered at autopsy include four men and two women ranging from 50 to 78 years of age. One patient was African American and five patients were white, all with multiple comorbidities. The tumors included diffuse large B-cell lymphoma, activated B-cell type, intravascular large B-cell lymphoma, ALK-negative anaplastic large cell lymphoma arising in a setting of human immunodeficiency virus, and a myeloid sarcoma. These cases illustrate the importance of the traditional postmortem examination in not only confirming clinical diagnoses but also identifying previously unknown diagnoses. Hematologic malignancies may present with nonspecific clinical manifestations, and this series of cases also emphasizes the necessity for widening the differential diagnosis in patients with unexplained lactic acidosis and hepatic failure to include hematopoietic malignancies since prompt treatment may be lifesaving. Copyright© by the American Society for Clinical Pathology.

  2. Rod-shaped microglia morphology is associated with aging in 2 human autopsy series.

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    Bachstetter, Adam D; Ighodaro, Eseosa T; Hassoun, Yasmin; Aldeiri, Danah; Neltner, Janna H; Patel, Ela; Abner, Erin L; Nelson, Peter T

    2017-04-01

    A subtype of microglia is defined by the morphological appearance of the cells as rod shaped. Little is known about this intriguing cell type, as there are only a few case reports describing rod-shaped microglia in the neuropathological literature. Rod-shaped microglia were shown recently to account for a substantial proportion of the microglia cells in the hippocampus of both demented and cognitively intact aged individuals. We hypothesized that aging could be a defining feature in the occurrence of rod-shaped microglia. To test this hypothesis, 2 independent series of autopsy cases (total n = 168 cases), which covered the adult lifespan from 20 to 100+ years old, were included in the study. The presence or absence of rod-shaped microglia was scored on IBA1 immunohistochemically stained slides for the hippocampus and cortex. We found that age was one of the strongest determinants for the presence of rod-shaped microglia in the hippocampus and the cortex. We found no association with the presence of rod-shaped microglia and a self-reported history of a TBI. Alzheimer's disease-related pathology was found to influence the presence of rod-shaped microglia, but only in the parietal cortex and not in the hippocampus or temporal cortex. Future studies are warranted to determine the functional relevance of rod-shaped microglia in supporting the health of neurons in the aged brain, and the signaling processes that regulate the formation of rod-shaped microglia. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Neural tube defects and associated anomalies in a fetal and perinatal autopsy series

    DEFF Research Database (Denmark)

    Nielsen, Ljudmilla A G; Maroun, Lisa Leth; Broholm, Helle

    2006-01-01

    morphological anomalies, and organ weights. Organ weights were evaluated according to new fetal autopsy standards and grouped as low, normal or high. Ninety-seven NTD cases were found (4.9%): Spina bifida (38 cases), cephalocele (17 cases) and anencephaly (42 cases). 63% of NTD cases had associated morphologic...

  4. Parity factors and prevalence of fibrocystic breast change in a forensic autopsy series.

    OpenAIRE

    Pathak, D. R.; Pike, M C; Key, C R; Teaf, S. R.; Bartow, S. A.

    1991-01-01

    The relationship of reproductive factors, such as nulliparous vs ever-parous status, age at first birth, and total parity, with morphologic prevalence of fibrocystic changes were examined using autopsy material from three ethnic/racial groups at varying risks for breast cancer. Although there was a trend toward a protective effect of ever-parous status, there was no statistically significant difference in the prevalence of fibrocystic disease in any group defined by parity status. The ethnic ...

  5. Violence against women: A series of autopsy studies from Istanbul, Turkey.

    Science.gov (United States)

    Unal, Esra Ozgun; Koc, Sermet; Unal, Volkan; Akcan, Ramazan; Javan, Gulnaz T

    2016-05-01

    Death is the most severe consequence of violence against women. The purpose of this study was to determine the frequency of violence-related deaths among women and the general characteristics of fatal violence cases against women in Istanbul, Turkey. A total of 20,486 forensic autopsies performed between 2006 and 2010, in Istanbul, were retrospectively analyzed. Of these, 537 violence-related deaths among women were included in the study. The victims were investigated in terms of sociodemographic characteristics, exposed type of violence, and autopsy findings. Out of all female deaths (n = 4165), 12.9% were due to violence against women, which comprised 2.6% of all autopsies (n = 20,456) performed during the study period in Istanbul. The median age of the victims was 43 years, and a significant proportion of victims (49.7%) were between the ages of 21 and 40 years. The deaths occurred most commonly in private residences (51.2%, n = 275), whereas the street was the crime scene for 14.5% (n = 78) of cases. Firearm injuries (50.1%, n = 269) were the most common cause of death, followed by stab wounds (28.3%, n = 152) and strangulation (8.4%, n = 45). Among the identified perpetrators, 52.3% were victims' spouses or boyfriends. The perpetrators were female in 4.4% (n = 16) of cases. Istanbul is the most important and cosmopolitan city of Turkey, representing the country's cultural characteristics. Therefore, the data obtained in this study may be strong indicators of violence against women in Turkey. Copyright © 2016 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  6. The 2002 results of the first series of follow-up studies on Japanese Thorotrast patients and their relationships to autopsy series

    Energy Technology Data Exchange (ETDEWEB)

    Mori, T.; Aoki, I. [Yokohama City Univ. School of Medicine, Yokohama (Japan); Machinami, R. [Kawakita General Hospital, Tokyo (Japan); Hatakeyama, S. [Tokyo Medical and Dental Univ., Tokyo (Japan); Fukutomi, K. [National Inst. of Public Health, Tokyo (Japan); Kato, Y.; Akashi, M. [National Inst. of Radiological Sciences, Chiba (Japan); Fukumoto, M. [Tohoku Univ. School of Medicine, Sendai (Japan)

    2005-07-01

    In 1963, a follow-up study was started on 262 war-wounded Japanese ex-servicemen who had been injected with thorotrast into blood vessels between 1931 and 1945. This first series of our follow-up studies on thorotrast patients covered a total of 71 years from 1931 to the present 2002 survey. It was supplemented in 1979 by another follow-up study called the second or Aichi series performed on other thorotrast-injected war-wounded persons. The 2002 survey of the first series indicated that 5 (1.9%) of 262 thorotrast cases were still alive, while 257 (98.1%) had died. Among 1,630 control war-wounded persons not treated with thorotrast, 348 (21.3%) were still alive and 1,282 (78.7%) had died. In an age-matched control population of 3,999,000 persons, 837,175 (20.9%) were alive and 3,161,825 (79.1%) had died. The life span of thorotrast patients was; thus, markedly shorten (about 18 years, P< 0.001) than that of controls. The main causes of death in the thorotrast patients were: 81 liver malignancies (30.9%), 19 liver cirrhoses (7.3%), 5 cancers of the extrahepatic bile duct (1.9%), 11 hematopoietic malignancies (4.2%). Statistical analyses by the {chi} {sup 2} test showed that the incidence of these disorders was significantly higher in the thorotrast group than the control group. From 1945 to 2002, autopsies have been performed on 404 thorotrast-treated-patients - 392 injected with thorotrast by vascular route and 12 injected by other routes. In vascularly injected autopsy cases, 266 liver malignancies (67.9%), 28 liver cirrhoses (7.1%), 12 cancers of extrahepatic bile duct (3.1%), 30 hematopoietic malignancies (7.7%); 2 bone sarcomas (0.5%), 16 lung cancers (4.1%), one hemangiosarcoma of the spleen (0.3%), 4 malignant peritoneal tumors (1.0%), and 7 sarcomas at the injection site (1.8%) were found. The relative risk estimate of liver malignancies and hematopoietic malignancies was significantly higher in the autopsied thorotrast patients than in the autopsied

  7. Sudden cardiac death in Brazil: a community-based autopsy series (2006-2010).

    Science.gov (United States)

    Braggion-Santos, Maria Fernanda; Volpe, Gustavo Jardim; Pazin-Filho, Antonio; Maciel, Benedito Carlos; Marin-Neto, José Antonio; Schmidt, André

    2015-02-01

    Sudden cardiac death (SCD) is a sudden unexpected event, from a cardiac cause, that occurs in less than one hour after the symptoms onset, in a person without any previous condition that would seem fatal or who was seen without any symptoms 24 hours before found dead. Although it is a relatively frequent event, there are only few reliable data in underdeveloped countries. We aimed to describe the features of SCD in Ribeirão Preto, Brazil (600,000 residents) according to Coroners' Office autopsy reports. We retrospectively reviewed 4501 autopsy reports between 2006 and 2010, to identify cases of SCD. Specific cause of death as well as demographic information, date, location and time of the event, comorbidities and whether cardiopulmonary resuscitation (CPR) was attempted were collected. We identified 899 cases of SCD (20%); the rate was 30/100000 residents per year. The vast majority of cases of SCD involved a coronary artery disease (CAD) (64%) and occurred in men (67%), between the 6th and the 7th decades of life. Most events occurred during the morning in the home setting (53.3%) and CPR was attempted in almost half of victims (49.7%). The most prevalent comorbidity was systemic hypertension (57.3%). Chagas' disease was present in 49 cases (5.5%). The majority of victims of SCD were men, in their sixties and seventies and the main cause of death was CAD. Chagas' disease, an important public health problem in Latin America, was found in about 5.5% of the cases.

  8. Sudden Cardiac Death in Brazil: A Community-Based Autopsy Series (2006-2010

    Directory of Open Access Journals (Sweden)

    Maria Fernanda Braggion-Santos

    2015-02-01

    Full Text Available Background: Sudden cardiac death (SCD is a sudden unexpected event, from a cardiac cause, that occurs in less than one hour after the symptoms onset, in a person without any previous condition that would seem fatal or who was seen without any symptoms 24 hours before found dead. Although it is a relatively frequent event, there are only few reliable data in underdeveloped countries. Objective: We aimed to describe the features of SCD in Ribeirão Preto, Brazil (600,000 residents according to Coroners’ Office autopsy reports. Methods: We retrospectively reviewed 4501 autopsy reports between 2006 and 2010, to identify cases of SCD. Specific cause of death as well as demographic information, date, location and time of the event, comorbidities and whether cardiopulmonary resuscitation (CPR was attempted were collected. Results: We identified 899 cases of SCD (20%; the rate was 30/100000 residents per year. The vast majority of cases of SCD involved a coronary artery disease (CAD (64% and occurred in men (67%, between the 6th and the 7th decades of life. Most events occurred during the morning in the home setting (53.3% and CPR was attempted in almost half of victims (49.7%. The most prevalent comorbidity was systemic hypertension (57.3%. Chagas’ disease was present in 49 cases (5.5%. Conclusion: The majority of victims of SCD were men, in their sixties and seventies and the main cause of death was CAD. Chagas’ disease, an important public health problem in Latin America, was found in about 5.5% of the cases.

  9. Analysis of the symmetric configuration of the circle of Willis in a series of autopsied corpses.

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    Stojanović, Nebojga; Stefanović, Ivica; Kostić, Aleksandar; Radisavejević, Misa; Stojanov, Dragan; Petrović, Sladjana

    2015-04-01

    The forming of the blood vessels network configuration at the base of the brain and interconnecting of blood vessels during the embryogenesis is directly related to the phylogenetic development of the brain and brain structures. A blood vessel configuration at the brain base, in the form of a ring or a hexagon, stands in direct relation to the perfusion needs of certain parts of the brain during its primary differentiation. The aim of this paper was to determine the incidence of certain blood vessel configurations at the base of the brain and understanding their symmetry or asymmetry. Analysis of the blood vessels at the base of the brain was performed on the autopsied subjects. The object of observation was the anterior segment of the circle of Willis consisting of C1- a. carotis interna (ICA), above a. communicaus posterior (PcoA), the segment A1 a. cerebri anterior (ACA) from a. carotis interna bifurcation to the a. communicans anterior (AcoA) and a communicans anterior itself, as well as the posterior segment consisting of PcoA and the segment P1--a. cerebri posterior (PCA) from the a. basilaris bifurcation to the PcoA. For the purpose of grouping the findings, the four basic configuration types of the circle of Willis were identified based on its symmetry or asymmetry. Type-A (symmetric circle of Willis), type-B (asymmetric circle of Willis' due to the unilateral hypoplastic A1-ACA); type-C (symmetric circle of Willis with bilateral symmetric changes on PcoA) and type-D (asymmetric circle of Willis due to the asymmetric changes on PcoA). Autosy was performed on 56 corpses. A total of 41 (73.2%) subjects were recorded with a symmetric configuration of the circle of Willis', of which 27 (48.2%) subjects had type A and 14 (25%) type C. The asymmetric configuration was present in 15 (26.8%) subjects, of whom 9 (16%) had type B and 6 (10.8%) subjects, of whom 9 (16%) had type B and 6 (10.8%) type D. The symmetric Willis group (73.2%) did not have a homogeneous

  10. Clinical Autopsy vs Medicolegal Autopsy

    OpenAIRE

    Kotabagi, RB; CHARATI, SC; Jayachandar, D

    2005-01-01

    Post mortem examination of a dead body is carried out to gain insight into the disease process as well as for forensic application of medical knowledge. Although different specialists viz; pathologists and forensic medicine experts, carry out autopsy for these two purposes, on many occasions there may be overlap of these two fields of medicine. A comparative analysis of both these categories of autopsies, namely clinical autopsy and medico legal autopsy, is done in this article with the inten...

  11. Contribution of Bacterial and Viral infections to Attributable Mortality in Patients with Severe Burns: An Autopsy Series

    Science.gov (United States)

    2010-01-01

    mortality (Table 4). The gram negative organisms with attributable mortality were Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli ...patients and 179 autopsies over 15 years. J Am Coll Surg 2006;202:536 48. [17] Sharma BR, Harish D, Singh VP, Bangar S. Septicemia as a cause of death in

  12. Series of Case Patients with Nontuberculous Mycobacteria Isolation, Central North Carolina, 2006-2010

    Science.gov (United States)

    Nontuberculous mycobacteria (NTM) infection/colonization, associated with human morbidity/mortality, is linked to drinking water and drinking water distribution systems. To characterize rates and distribution of NTM isolation among residents living in three North Carolina countie...

  13. Needle autopsy

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    Philip Davis Marsden

    1997-04-01

    Full Text Available Often in tropical practice there is not time or conditions to do a proper autopsy on a patient who has died. A needle biopsy technique is described for limited closed autopsy examination to clariffy organ histology. In this way the clinician may resolve puzzling fatal disease.Muitas vezes, em clínicas de países tropicais, não há tempo nem condições para se realizar uma necropsia adequada em um paciente que foi a óbito. Um técnica de biópsia por punção é descrita para fins de exame em necropsia limitadamente fechada, para esclarecimento da histologia do órgão. Dessa maneira, o clínico pode resolver enigmas de doenças fatais.

  14. Incipient progressive supranuclear palsy is more common than expected and may comprise clinicopathological subtypes: a forensic autopsy series.

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    Yoshida, Koji; Hata, Yukiko; Kinoshita, Koshi; Takashima, Shutaro; Tanaka, Kortaro; Nishida, Naoki

    2017-05-01

    We investigated 998 serial Japanese forensic autopsy cases (0-101 years old, mean age 61.7 ± 21.9), with no case selection, using immunohistochemistry to detect cases with progressive supranuclear palsy (PSP). Twenty-nine cases (mean age 82.3 ± 7.2 years, 11 males, 18 females) fulfilled the National Institute of Neuronal Disorders and Stroke (NINDS)-PSP pathological criteria (2.9% of all cases, 4.6% of cases over 60). All had neuronal and glial inclusions in the basal ganglia and brainstem. However, 13 cases had low tau pathology and were categorized as atypical PSP. In addition to PSP pathology, multiple types of astrocytic inclusions and comorbid proteinopathies, particularly a high prevalence of argyrophilic grain disease, were found. All cases had not been diagnosed with PSP and had preserved daily functioning prior to death. However, 14 (48.3%), 11 (37.9%), and 16 (55.2%) cases showed signs of dementia, depressive state, and gait disturbance, respectively. Sixteen accidental death cases (55.2%), including from falls and getting lost, and 11 suicide cases (37.9%) appear to have a relationship with incipient PSP pathology. Cluster analysis using the distribution and amount of 4-repeat-tau pathology classified the cases into three subgroups: Group 1 (10 cases) had typical PSP pathology and seven cases (70.0%) had dementia as the most frequent symptom; Group 2 (7 cases) had significantly higher frequency of gait disorder (6 cases, 85.7%), and less neocortical tau pathology than Group 1; Group 3 (12 cases) had relatively mild PSP pathology and high argyrophilic grain burdens. Granular-shaped astrocytes were the dominant astrocytic inclusion in all cases. We conclude that in forensic cases incipient PSP occurs with a higher prevalence than expected. If these findings can be extrapolated to other population-based cohorts, PSP may be more common than previously thought.

  15. Informatics and Autopsy Pathology.

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    Levy, Bruce

    2015-06-01

    Many health care providers believe that the autopsy is no longer relevant in high-technology medicine era. This has fueled a decline in the hospital autopsy rate. Although it seems that advanced diagnostic tests answer all clinical questions, studies repeatedly demonstrate that an autopsy uncovers as many undiagnosed conditions today as in the past. The forensic autopsy rate has also declined, although not as precipitously. Pathologists are still performing a nineteenth century autopsy procedure that remains essentially unchanged. Informatics offers several potential answers that will evolve the low-tech autopsy into the high-tech autopsy. Copyright © 2015 Elsevier Inc. All rights reserved.

  16. Virtual autopsy in hanging.

    Science.gov (United States)

    Polacco, Matteo; D'Alessio, Pasquale; Ausania, Francesco; Zobel, Bruno; Pascali, Vincenzo Lorenzo; d'Aloja, Ernesto; Miscusi, Massimo; De-Giorgio, Fabio

    2013-06-01

    The aim of the study was to compare postmortem computed tomographic (CT) imaging findings from a case of hanging with the autopsy findings. The CT showed a good match with autopsy findings especially for bone, soft tissue, and spinal injuries. The CT images of the injuries of the neck obtained by CT scan clearly showed the ligature mark, the hemorrhagic suffusion in the soft tissue (thickening of derma) and in the muscles (sternocleidomastoid) of the neck. Furthermore, CT 3-dimensional reconstruction showed brain edema, fracture of the left posterior horn of the hyoid bone, and a grade 1 retrolisthesis of C5 on C6. This last finding was not detected by autopsy because of the anterior approach that is frequently used in necropsy technique. Nevertheless, the CT virtual autopsy did not show vascular findings (like Amussat mark) because a barium mixture was not injected in the body.

  17. The value of neonatal autopsy.

    LENUS (Irish Health Repository)

    Hickey, Leah

    2012-01-01

    Neonatal autopsy rates were in decline internationally at the end of the last century. Our objective was to assess the current value of neonatal autopsy in providing additional information to families and healthcare professionals.

  18. Virtual CT autopsy in clinical pathology: feasibility in clinical autopsies.

    Science.gov (United States)

    Westphal, Saskia E; Apitzsch, Jonas; Penzkofer, Tobias; Mahnken, Andreas H; Knüchel, Ruth

    2012-08-01

    For the past century, autopsy techniques in clinical pathology have not changed significantly, while autopsy rates are declining. Modern imaging techniques offer interesting prospects of supportive post-mortem diagnostic investigation. In a prospective study of 29 autopsy cases, complimentary virtual autopsy using unenhanced post-mortem computed tomography (pmCT) was performed. We analysed in a prospective cohort study 29 unenhanced pmCT scans, generated prior to autopsy. Clinical information regarding clinical history and circumstances of death were provided. The objective of the study was to find consistency and/or discrepancy between virtual autopsy and conventional autopsy findings regarding cause of death and death-related diagnoses, reconstruction of the pathogenetic mechanisms involved, side diagnoses and CPR (cardiopulmonary resuscitation)- or death-related post-mortem changes. Accuracy of pmCT for cause of death was 68 % and the positive predictive value (PPV) was 75 %. Regarding the pathogenetic mechanisms, accuracy of pmCT was 21 % and PPV was 29 %. The combined diagnostic yield of autopsy and pmCT was 133 % compared to autopsy only. Modern imaging techniques give an opportunity for post-mortem diagnostics to complete but not yet replace traditional autopsy. We could show that in two out of three cases, the cause of death found by pmCT matched the diagnosis from classical autopsy. While both disciplines, pathology and radiology, will profit from the mutual exchange of data, it seems a realistic aim to strive for virtual autopsy possibly further supported by biopsies and contrast-enhanced pmCT as an alternative to the classical clinical autopsy. A combination of both methods enhances diagnostic quality and completeness of the autopsy report.

  19. Virtopsy versus digital autopsy: virtual autopsy.

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    Pomara, C; Fineschi, V; Scalzo, G; Guglielmi, G

    2009-12-01

    Multislice computed tomography (MSCT) and magnetic resonance imaging (MRI) are being increasingly implemented in forensic pathology. These methods may serve as an adjuvant to classic forensic autopsies. Imaging of the interior of corpses is performed using MSCT and/or MRI. MRI, in addition, is also well suited to the examination of surviving victims of assault, especially choking, and helps visualise internal injuries sometimes not seen on external examination of the victim. Various postprocessing techniques can provide strong forensic evidence for use in legal proceedings. The documentation and analysis of postmortem findings with MSCT and MRI and postprocessing techniques (virtopsy) is investigator independent, objective and noninvasive and will lead to qualitative improvements in forensic pathologic investigation. Apart from the accuracy and three dimensionality that conventional documentations lack, these techniques allow for the re-examination of the corpse and the crime scene even decades later, after burial of the corpse and liberation of the crime scene. We believe that this virtual, noninvasive or minimally invasive approach will improve forensic medicine in the near future.

  20. [Virtual autopsy--why not?].

    Science.gov (United States)

    Blaauwgeers, J L G Hans; van Rijn, Rick R

    2012-01-01

    The number of autopsies carried out by pathologists is decreasing. This is worrying, as evaluation has shown 10-20% of autopsies result in findings which could have influenced the course and treatment of the disease if they had been known about in time. Post-mortem imaging or virtual autopsy may be an alternative. However, a number of practical matters have to be taken into consideration before virtual autopsy becomes widely-accepted practice. These include availability of a CT scanner on request, the logistics of complex procedures on the deceased, new forms of expertise, co-operation between pathologist and radiologist, and financing.

  1. Agonal Thrombi at Autopsy.

    Science.gov (United States)

    Hansma, Patrick; Powers, Stephanie; Diaz, Francisco; Li, Wei

    2015-09-01

    Clots and thrombi identified at autopsy are generally classified dichotomously as antemortem or postmortem. Current articles and textbooks support this approach. Earlier literature often contained descriptions of a third category, the agonal thrombus that forms while the patient is dying. We collected 238 autopsy cases including 80 rapid/sudden deaths by violence and 21 (including 1 pediatric) deaths from acute pulmonary emboli. We analyzed the gross and microscopic features of clots and thrombi. Agonal thrombi were identified in 122 cases (89% of cases of "slow" death). Agonal thrombi were not identified in cases of sudden death. We found that a comprehensive description of the macroscopic features was a key to interpretation. The gross and microscopic features of agonal thrombi "chicken fat" support their hybrid nature. The dichotomous classification of clots and thrombi seems to be founded on assumptions of clinical significance but is perhaps oversimplified. Agonal thrombi area distinct class of thrombus that, although not clinically significant as an immediate cause of death, arises by its own mechanisms and has its own morphology. It is advisable to avoid classifying agonal thrombi as mere postmortem clots because in forensic cases, they may help support an argument against sudden death.

  2. Family members' experiences of autopsy

    NARCIS (Netherlands)

    Oppewal, F; Meyboom-de Jong, B

    Background. The experiences of family members will teach us how to handle an autopsy, the ultimate quality assessment tool. Objective. The aim of this study was to determine surviving family members' experience of autopsy. Method. Seven GPs were asked to approach surviving family members of

  3. Virtopsy: Touch-free autopsy

    OpenAIRE

    Raj Kumar Badam; Triekan Sownetha; D B Gandhi Babu; Shefali Waghray; Lavanya Reddy; Komali Garlapati; Sunanda Chavva

    2017-01-01

    The word “autopsy” denotes “to see with own eyes.” Autopsy (postmortem) is a process that includes a thorough examination of a corpse noting everything related to anatomization, surface wounds, histological and culture studies. Virtopsy is a term extracted from two words “virtual” and “autopsy.” It employs imaging methods that are routinely used in clinical medicine such as computed tomography and magnetic resonance imaging in the field of autopsy, to find the reason for death. Virtopsy is a ...

  4. Virtopsy: Touch-free autopsy.

    Science.gov (United States)

    Badam, Raj Kumar; Sownetha, Triekan; Babu, D B Gandhi; Waghray, Shefali; Reddy, Lavanya; Garlapati, Komali; Chavva, Sunanda

    2017-01-01

    The word "autopsy" denotes "to see with own eyes." Autopsy (postmortem) is a process that includes a thorough examination of a corpse noting everything related to anatomization, surface wounds, histological and culture studies. Virtopsy is a term extracted from two words "virtual" and "autopsy." It employs imaging methods that are routinely used in clinical medicine such as computed tomography and magnetic resonance imaging in the field of autopsy, to find the reason for death. Virtopsy is a multi-disciplinary technology that combines forensic medicine and pathology, roentgenology, computer graphics, biomechanics, and physics. It is rapidly gaining importance in the field of forensics. This approach has been recently used by forensic odontologists, but yet to make its own mark in the field. This article mainly deals with "virtopsy" where in various articles were web searched, relevant data was selected, extracted, and summarized here.

  5. Congenital hyperthyroidism: autopsy report

    Directory of Open Access Journals (Sweden)

    Lima Marcus Aurelho de

    1999-01-01

    Full Text Available We report the autopsy of a stillborn fetus with congenital hyperthyroidism born to a mother with untreated Graves' disease, whose cause of death was congestive heart failure. The major findings concerned the skull, thyroid, heart, and placenta. The cranial sutures were closed, with overlapping skull bones. The thyroid was increased in volume and had intense blood congestion. Histological examination showed hyperactive follicles. The heart was enlarged and softened, with dilated cavities and hemorrhagic suffusions in the epicardium. The placenta had infarctions that involved at least 20% of its surface, and the vessels of the umbilical cord were fully exposed due to a decrease in Wharton 's jelly. Hyperthyroidism was confirmed by the maternal clinical data, the fetal findings of exophthalmia, craniosynostosis, and goiter with signs of follicular hyperactivity. Craniosynostosis is caused by the anabolic action of thyroid hormones in bone formation during the initial stages of development. The delayed initiation of treatment in the present case contributed to the severity of fetal hyperthyroidism and consequent fetal death.

  6. The Impact of Incentives on Effort: Teacher Bonuses in North Carolina. Program on Education Policy and Governance Working Papers Series. PEPG 10-06

    Science.gov (United States)

    Ahn, Tom; Vigdor, Jake

    2010-01-01

    Teacher effort, a critical component of education production, has been largely ignored in the literature due to measurement difficulties. Using a principal-agent model, North Carolina public school data, and the state's unique accountability system that rewards teachers for school-level academic growth, we show that we can distill effort from…

  7. Perceptions of near virtual autopsies.

    Science.gov (United States)

    Rutty, Guy N; Rutty, Jane E

    2011-10-01

    We present for the first time to our knowledge an insight into pathology/medico-legal practitioners' and general public perceptions' of the use of computed tomography (CT) scanning as an alterative to the invasive autopsy. The study arises from questionnaires at two professional meetings before and after an informative talk on the current use of CT in medico-legal autopsy practice. A total of 45 general public and 27 pathologists/medico-legal practitioners completed both parts of the study. A combination of open and closed questions were used to allow thematic and descriptive statistical analysis. The results show commonalities and differences of opinions between the two study groups. A desire was identified from the public to use CT scanning as an alternative to invasive autopsy if available. However, the majority of the public questioned indicated that they would not object to an invasive autopsy being undertaken on their relative if one was authorised by a coroner; it was the pathologists who questioned the need for the examination. However, although they raised this question, the pathologists still expressed the preference of the traditional invasive autopsy over a CT scan. Copyright © 2011 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  8. Maternal mortality: An autopsy audit

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    Jashnani K

    2009-01-01

    Full Text Available Background: The process of audit standardizes protocols in departments and has long-term benefits. Maternal autopsies though routinely performed, deserve a special attention. Aims: This study was carried out to calculate the maternal mortality ratio (MMR in a tertiary care hospital and to correlate final cause of death with the clinical diagnosis. An audit of maternal autopsies was carried out to evaluate current practices, identify fallacies and suggest corrective measures to rectify them. Materials and Methods: Eighty-nine autopsies of maternal deaths in the period 2003 to 2007 were studied in detail along with the clinical details. Results: There were 158 maternal deaths and 13940 live births in this five-year period. Maternal mortality rate was found to be very high (1133/ 100000 live births in our institution with a high number of complicated referral cases (68/89 cases, 76%. Of the 89 autopsies, acute fulminant viral hepatitis was the commonest cause of indirect maternal deaths (37 cases, 41.5%. This was followed by direct causes like pregnancy-induced hypertension (12 cases, 13.4% and puerperal sepsis (10 cases, 11.2%. Certain fallacies were noted during the audit process. Conclusion: During the audit it was realized that in maternal mortality autopsies, special emphasis should be given to clinicopathologic correlation, microbiological studies, identification of thromboembolic phenomenon and adequate sectioning of relevant organs. We found difficulty in identification of placental bed in the uterus in postpartum autopsies. A systematic approach can help us for better understanding of the pathophysiology of diseases occurring in pregnancy.

  9. The Role of Forensic Autopsies in Diagnosis of Cancer

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    Gülden Çengel

    2014-07-01

    . Cause of death was considered as cancer related complications in 58 cases (73.4%, other natural causes in 6 cases (7.6% and external factors such as traumas and intoxications in 10 cases (12.7%. The cause of could not determined following complete autopsy and postmortem investigation in 5 cases (6.3%. Conclusion: Providing accurate cancer statistics by only clinical trials or medical autopsies that are diminished nowadays and clinical cancer outputs seems to be inadequate. We participated that investigating malignancies in large series of forensic autopsies would be contributed to data about public health. Keywords: cancer, medicolegal autopsy, cause of death

  10. 20 CFR 718.106 - Autopsy; biopsy.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Autopsy; biopsy. 718.106 Section 718.106... PNEUMOCONIOSIS Criteria for the Development of Medical Evidence § 718.106 Autopsy; biopsy. (a) A report of an autopsy or biopsy submitted in connection with a claim shall include a detailed gross macroscopic and...

  11. Introduction of autopsy imaging redefines the concept of autopsy: 37 cases of clinical experience.

    Science.gov (United States)

    Ezawa, Hidefumi; Yoneyama, Ryuichi; Kandatsu, Susumu; Yoshikawa, Kyosan; Tsujii, Hirohiko; Harigaya, Kenichi

    2003-12-01

    A new autopsy imaging (AI) system was introduced at the Research Center Hospital for Charged Particle Therapy (RCCPT) in January 2000. Autopsy imaging is a postmortem and preautopsy diagnostic procedure using magnetic resonance imaging (MRI). Scanning is performed with a 1.5 Tesla MRI system before autopsy. The AI results are reported to the pathologist and, in light of this information, autopsy is performed with minute precision. Autopsy imaging was performed on 37 cancer cases. In seven cases, AI was less informative than the autopsy, but in 30 cases, more precise reports on the final diagnosis were available with the combined application of autopsy and AI than autopsy alone, particularly in eight limited autopsy cases. Thus, AI provides critical and supplementary information for autopsy; furthermore, AI itself is a unique imaging system of great importance.

  12. [Clinical autopsies in Switzerland : A status report].

    Science.gov (United States)

    Rodewald, A-K; Bode, P; Cathomas, G; Moch, H

    2017-07-27

    The number of autopsies has been steadily declining worldwide over the past decades. The reasons for this are diverse. Legislation regarding opposition and consent rules does not appear to have had a significant impact on the autopsy rates. Above all, structural causes and the attitude of the medical profession are the reasons for this decline. The main argument for a high autopsy rate is the identification of diagnostic errors; however, diagnostic discrepancies are relatively independent of the rate of autopsies performed. At the University Hospital (UniversitätsSpital) Zurich it could be shown in a study that from 1972-2002 the frequency of relevant diagnostic discrepancies (classes I and II) decreased from 30% to 7%. The aim of this article is to present the necessity of a stable autopsy rate and to examine the situation of the autopsy in Switzerland. For this purpose, the importance of autopsies in the fields of quality assurance of medical diagnostics, cancer statistics, medical research as well as further education of doctors in Switzerland is shown. Efforts are being made by the pathologists to counteract the declining autopsy rates. Declining autopsy numbers have a significant influence on cancer statistics. The rate of newly discovered tumors in autopsies in Switzerland decreased from 42% in 1980 to 17% in 2010. Pediatric autopsies are an important tool for quality assurance of medical diagnostics in neonatology and pediatrics in Switzerland, but the rate of autopsies carried out is also declining. Postmortem magnetic resonance imaging (MRI) examinations (virtopsy) could increase the acceptance of the parents for an autopsy in the future. Autopsies make an important contribution in research and in documentation of therapy-associated side effects and they are an important component of further education of the upcoming medical generations.

  13. Blunt thoracic aortic injuries: an autopsy study.

    Science.gov (United States)

    Teixeira, Pedro G R; Inaba, Kenji; Barmparas, Galinos; Georgiou, Chrysanthos; Toms, Carla; Noguchi, Thomas T; Rogers, Christopher; Sathyavagiswaran, Lakshmanan; Demetriades, Demetrios

    2011-01-01

    The objective of this study was to identify the incidence and patterns of thoracic aortic injuries in a series of blunt traumatic deaths and describe their associated injuries. All autopsies performed by the Los Angeles County Department of Coroner for blunt traumatic deaths in 2005 were retrospectively reviewed. Patients who had a traumatic thoracic aortic (TTA) injury were compared with the victims who did not have this injury for differences in baseline characteristics and patterns of associated injuries. During the study period, 304 (35%) of 881 fatal victims of blunt trauma received by the Los Angeles County Department of Coroner underwent a full autopsy and were included in the analysis. The patients were on average aged 43 years±21 years, 71% were men, and 39% had a positive blood alcohol screen. Motor vehicle collision was the most common mechanism of injury (50%), followed by pedestrian struck by auto (37%). A TTA injury was identified in 102 (34%) of the victims. The most common site of TTA injury was the isthmus and descending thoracic aorta, occurring in 67 fatalities (66% of the patients with TTA injuries). Patients with TTA injuries were significantly more likely to have other associated injuries: cardiac injury (44% vs. 25%, p=0.001), hemothorax (86% vs. 56%, pinjury (74% vs. 49%, pinjury. Patients with a TTA injury were significantly more likely to die at the scene (80% vs. 63%, p=0.002). Thoracic aortic injuries occurred in fully one third of blunt traumatic fatalities, with the majority of deaths occurring at the scene. The risk for associated thoracic and intra-abdominal injuries is significantly increased in patients with thoracic aortic injuries.

  14. Medico-legal autopsies in Denmark

    DEFF Research Database (Denmark)

    Larsen, Sara Tangmose; Lynnerup, Niels

    2011-01-01

    At 2.7% in 1970, the Danish medico-legal autopsy frequency was lower than recent frequencies observed in the Nordic countries (4-24%). The aim of this study was to analyse trends in the number and frequency of Danish medico-legal autopsies.......At 2.7% in 1970, the Danish medico-legal autopsy frequency was lower than recent frequencies observed in the Nordic countries (4-24%). The aim of this study was to analyse trends in the number and frequency of Danish medico-legal autopsies....

  15. Aerospace Accident - Injury Autopsy Data System -

    Data.gov (United States)

    Department of Transportation — The Aerospace Accident Injury Autopsy Database System will provide the Civil Aerospace Medical Institute (CAMI) Aerospace Medical Research Team (AMRT) the ability to...

  16. Autopsy practice in forensic pathology - evidence-based or experience-based? a review of autopsies performed on victims of traumatic asphyxia in a mass disaster.

    Science.gov (United States)

    Colville-Ebeling, Bonnie; Freeman, Michael; Banner, Jytte; Lynnerup, Niels

    2014-02-01

    Current autopsy practice in forensic pathology is to a large extent based on experience and individual customary practices as opposed to evidence and consensus based practices. As a result there is the potential for substantial variation in how knowledge is applied in each case. In the present case series, we describe the variation observed in autopsy reports by five different pathologists of eight victims who died simultaneously from traumatic asphyxia due to compression during a human stampede. We observed that there was no mention of the availability of medical charts in five of the reports, of potentially confounding resuscitation efforts in three reports, of cardinal signs in seven reports and of associated injuries to a various degree in all reports. Further, there was mention of supplemental histological examination in two reports and of pre-autopsy radiograph in six reports. We inferred that reliance on experience and individual customary practices led to disparities between the autopsy reports as well as omissions of important information such as cardinal signs, and conclude that such reliance increases the potential for error in autopsy practice. We suggest that pre-autopsy data-gathering and the use of check lists specific to certain injury causes are likely to result in less deviation from evidence-based practices in forensic pathology. Pre-autopsy data-gathering and check lists will help ensure a higher degree of standardization in autopsy reports thus enhancing the quality and accuracy of the report as a legal document as well as rendering it more useful for data-gathering efforts. Copyright © 2013 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  17. Autopsy

    Science.gov (United States)

    ... Mental Health Sex and Birth Control Sex and Sexuality Birth Control Family HealthInfants and Toddlers Kids and Teens Pregnancy and ... Mental Health Sex and Birth Control Sex and Sexuality Birth Control Family HealthInfants and Toddlers Kids and Teens Pregnancy and ...

  18. [Causes of death in congenital hypothyroidism. An autopsy study].

    Science.gov (United States)

    Ridaura-Sanz, C; López-Corella, E

    1995-01-01

    Children with congenital hypothyroidism are prone to die unexpectedly. In order to test this hypothesis, the primary and contributing causes of death were studied in a case series of sixteen consecutive children coming to autopsy. Four patients with absent thyroid died undiagnosed and untreated. The remaining twelve cases had documented hypothyroidism with low T3 and T4 levels. Diagnosis was established after the age of two months. Nine of the sixteen cases died unexpectedly, three while in the hospital and six at home. Autopsy findings suggested bronchoaspiration in five and heart failure in four. The remaining seven cases died under predictable circumstances with serious infections. Children with congenital hypothyroidism with delayed treatment may die unexpectedly as a result of the organic dysfunction caused by their primary disease.

  19. Students' Opinions on Autopsy and Death

    African Journals Online (AJOL)

    Northern Ireland the hospital autopsy rate fell from 22% in 1990 to 8% in 1999.4. Despite its important contribution to medical training, research and medical audit, students graduate from some medical schools without having witnessed a formal autopsy,1,6 with some students and even doctors disregarding its value.7,8 The ...

  20. Value of the perinatal autopsy : Critique

    NARCIS (Netherlands)

    Gordijn, SJ; Erwich, JJHM; Khong, TY

    2002-01-01

    In consenting to a perinatal autopsy, the primary motive of parents may be to find the exact cause of death. A critical review on the value of perinatal autopsies was performed to see whether parents could be counseled regarding their main motive. A literature search was performed in MEDLINE,

  1. CONTRIBUTION OF AUTOPSY TO MEDICAL PRACTICE IN ...

    African Journals Online (AJOL)

    one would expect to find more scientific autopsy requests in natural deaths, while medico-legal autopsies are common in 'forensic' deaths (road traffic accidents, poisoning, physical aggression) [13]. This controversy is explained by the fact that most deaths in our community, even in hospitalized patients are termed.

  2. Utah Youth Suicide Study: Psychological Autopsy

    Science.gov (United States)

    Moskos, Michelle; Olson, Lenora; Halbern, Sarah; Keller, Trisha; Gray, Doug

    2005-01-01

    We conducted a psychological autopsy study to further understand youth suicide in Utah. While traditional psychological autopsy studies primarily focus on the administration of psychometric measures to identify any underlying diagnosis of mental illness for the suicide decedent, we focused our interviews to identify which contacts in the…

  3. Minimally invasive, imaging guided virtual autopsy compared to conventional autopsy in foetal, newborn and infant cases: study protocol for the paediatric virtual autopsy trial

    OpenAIRE

    Rüegger, Christoph M; Bartsch, Christine; Martinez, Rosa Maria; Ross, Steffen; Bolliger, Stephan A; Koller, Brigitte; Held, Leonhard; Bruder, Elisabeth; Bode, Peter Karl; Caduff, Rosmarie; Frey, Bernhard; Schäffer, Leonhard; Bucher, Hans Ulrich

    2014-01-01

    BACKGROUND: In light of declining autopsy rates around the world, post-mortem MR imaging is a promising alternative to conventional autopsy in the investigation of infant death. A major drawback of this non-invasive autopsy approach is the fact that histopathological and microbiological examination of the tissue is not possible. The objective of this prospective study is to compare the performance of minimally invasive, virtual autopsy, including CT-guided biopsy, with conventional autopsy pr...

  4. Baccalaureate Nursing Students' Perceptions Regarding Autopsy Experiences.

    Science.gov (United States)

    Cannon, Emily J; Bauer, Renee N

    Since 2012, a medical-surgical nursing course at a midsized state university has provided the opportunity for students to view autopsies with a board-certified forensic pathologist. The autopsies are performed at a midsized hospital relatively close to the campus. The purpose of this study was to discover nursing students' perceptions that emerged during the autopsy experience. A convenience sample of 23 baccalaureate nursing students took part in the autopsy experience over a 4-month period. Archival data from an online, anonymous questionnaire, completed after the experience, were reviewed and subjected to qualitative analysis. This study was approved by the university's institutional review board. Rich data emerged regarding the students' experiences, including emotional, psychological, and knowledge-based perceptions. Autopsies are important learning tools for nursing students, especially those who go into advanced practice nursing and forensic nursing. Anatomy, physiology, and pathophysiology are essential for students to understand as they learn about medical-surgical nursing concepts. Unique emotional characteristics of the students and cause of death of the deceased influenced how some students viewed the autopsy experience. Students reported that processing and debriefing activities were important after viewing autopsies and should be encouraged.

  5. Auditing Autopsies: Lagos University Teaching Hospital Experience ...

    African Journals Online (AJOL)

    antemortem diagnosis) with autopsies (post-mortem diagnosis) on patients managed at Lagos University Teaching Hospital (LUTH) between October 1999 and November, 2000. In the study period, a total of 1843 deaths were registered out of which ...

  6. Myocardial bridges: a prospective forensic autopsy study

    National Research Council Canada - National Science Library

    Micić-Labudović, Jelena; Atanasijević, Tatjana; Popović, Vesna; Mihailović, Zoran; Nikolić, Slobodan; Puzović, Dragana

    2015-01-01

    ...) in the autopsy material considering the descending branch of the LAD to be the most important one in the nourishment of the myocardium and myocardial bridges to be the most frequent in its area...

  7. Autopsy and medical education: a review.

    OpenAIRE

    Charlton, R

    1994-01-01

    During the twentieth century there has been a decline in the rate of autopsies performed. A review of the literature reveals reasons for this decline which include: an improvement in the medical diagnostic technology available; inadequate training of doctors as to the importance of autopsy; and difficulties in obtaining consent from relatives and the present use of audit. Recommendations for changes in medical education are made which include: a greater appreciation of the procedure as a usef...

  8. Minimally invasive, imaging guided virtual autopsy compared to conventional autopsy in foetal, newborn and infant cases: study protocol for the paediatric virtual autopsy trial

    National Research Council Canada - National Science Library

    Rüegger, Christoph M; Bartsch, Christine; Martinez, Rosa Maria; Ross, Steffen; Bolliger, Stephan A; Koller, Brigitte; Held, Leonhard; Bruder, Elisabeth; Bode, Peter Karl; Caduff, Rosmarie; Frey, Bernhard; Schäffer, Leonhard; Bucher, Hans Ulrich

    2014-01-01

    .... The objective of this prospective study is to compare the performance of minimally invasive, virtual autopsy, including CT-guided biopsy, with conventional autopsy procedures in a paediatric population...

  9. Parental acceptance of minimally invasive fetal and neonatal autopsy compared with conventional autopsy.

    Science.gov (United States)

    Kang, Xin; Cos, Teresa; Guizani, Meriem; Cannie, Mieke M; Segers, Valérie; Jani, Jacques C

    2014-11-01

    To determine parental acceptance of minimally invasive autopsy (MIA) involving postmortem imaging and organ tissue sampling compared with conventional autopsy and to compare the acceptability of percutaneous versus laparoscopic-guided biopsy. Following termination of pregnancy parents were offered the option of traditional autopsy and subsequently interviewed about their acceptance of MIA. The McNemar test for paired samples was used to assess the difference in acceptance of MIA and conventional autopsy. The Wilcoxon signed-rank test for paired samples was used to compare the acceptance score for percutaneous versus laparoscopic-guided biopsy. Logistic regression was selected to study the association of parental acceptance of conventional autopsy and MIA with different variables. Conventional autopsy was accepted by 42 (60.0%) of the 70 parents. Regression analysis showed that non-Muslim faith was the only factor significantly associated with acceptance of conventional autopsy (p = 0.030). Of 28 parents who initially refused conventional autopsy, 13(46.4%) subsequently accepted MIA, increasing acceptance to 78.6% (p < 0.001). Regression analysis showed that none of the factors significantly affected MIA acceptance. Parents expressed no preference between postmortem percutaneous versus laparoscopic-guided biopsy (p = 0.061). Post-mortem imaging combined with systematic organ biopsies is highly acceptable among all parents independent of their religion and the method used for organ biopsy. © 2014 John Wiley & Sons, Ltd.

  10. Autopsy standards of body parameters and fresh organ weights in nonmacerated and macerated human fetuses

    DEFF Research Database (Denmark)

    Maroun, Lisa Leth; Graem, Niels

    2005-01-01

    Standards for body parameters and organ weights are important tools in fetal and perinatal pathology. Previously there has been only a weak emphasis on the effect of maceration on dimensions and weights. This study provides autopsy standards for body weight, body dimensions, and fresh organ weights...... for nonmacerated fetuses and for mildly, moderately, and markedly macerated fetuses at 12 to 43 weeks of gestation. Cases were selected from a consecutive series of 1800 fetal and perinatal autopsies. Cases with malformations, hydrops, infection, or chromosomal abnormality, fetuses from multiple births...

  11. Forensic autopsies in a naturalistic setting in Norway: autopsy rates and toxicological findings.

    Science.gov (United States)

    Frost, Joachim; Slørdal, Lars; Vege, Åshild; Nordrum, Ivar S

    2012-11-30

    Autopsies can give valuable information about the cause of death, and represent an important tool for obtaining valid cause of death statistics. In particular, they may shed light on the circumstances of death in ambiguous and criminal cases. To address the need for information on current autopsy practices, forensic autopsy rates in two counties in Central Norway over the period 2007-2009 were assessed. To investigate toxicological findings that could possibly remain undisclosed without the performance of an autopsy, the impact of alcohol and drugs in forensic autopsy cases from this material was evaluated. The total forensic autopsy rate in this material was 3%. The forensic autopsy rates were low for natural deaths (1%), accidental falls (12%) and the heterogeneous category "other accidents" (21%), relatively high for accidental poisonings (84%), and less than adequate for road traffic accidents (57%). For suicides the forensic autopsy rate was 63%, and for recognized homicides 100%. The total forensic autopsy rate was higher for men than for women (5% vs. 2%), and decreased with age, being 38% in the age group 59 years. Despite that Norwegian legislation and regulations regarding forensic autopsy requests are national, the forensic autopsy rates were generally lower in the county of Nord-Trøndelag than in Sør-Trøndelag, with most striking differences in suicide deaths (11% vs. 91%) and road traffic accidents (46% vs. 67%). This illustrates how autopsy rates, and possibly cause of death registries, might be susceptible to the influence of regional variations in law enforcement, with possible consequences for the quality and validity of cause of death statistics. Of the forensic autopsy cases where toxicological analysis was performed (361 of 364 cases) a total of 71% had positive toxicology results; 12% were positive for alcohol only, 44% were positive for drugs only, and 15% were positive for both alcohol and drugs. The toxicology results suggest that alcohol

  12. Minimally invasive autopsy by using postmortem endoluminal and transluminal endoscopy and EUS.

    Science.gov (United States)

    Denzer, Ulrike W; von Renteln, Daniel; Lübke, Andreas; Heinemann, Axel; Rösch, Thomas; Püschel, Klaus; Karbe, Tom

    2013-11-01

    Virtual autopsy by using CT imaging has been introduced as an alternative to conventional autopsy and has resulted in an increase in acceptance of autopsy by relatives. Because direct inspection and tissue acquisition is not possible by imaging alone, various endoscopic techniques can be considered of complementary usefulness. We present the first series of sequential endoscopic techniques including natural orifice transluminal access for minimally invasive autopsy. University hospital, legal medicine department. Twenty deceased subjects. Various flexible endoscopic modalities including EUS, with biopsy or EUS-guided FNA, were attempted. This included transluminal intra-abdominal endoscopic exploration with tissue sampling in a few cases. Completeness of inspection of the luminal and extraluminal cavity as well as tissue acquisition. Complete upper GI endoscopy was performed in 17 of 20 and EUS in 8 of 8 cases. In addition, transgastric intra-abdominal endoscopy was successfully performed in 5 cases. Adequate histology from biopsy and EUS-guided puncture could be obtained in case of short time intervals post mortem. In 1 case, a rupture of the gastric cardia with bleeding was diagnosed as a significant unexpected finding. New minor pathological findings were revealed on EGD (6/17), GI EUS (3/8), and transgastric inspection (4/5). Limited number of cases for all procedures. Minimally invasive autopsy by using multiple endoscopic techniques for imaging and tissue acquisition is feasible. The significant value of this technique, in combination with virtual autopsy compared with classic autopsy, warrants further evaluation. Copyright © 2013 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.

  13. VIRTOPSY - the Swiss virtual autopsy approach.

    Science.gov (United States)

    Thali, Michael J; Jackowski, Christian; Oesterhelweg, Lars; Ross, Steffen G; Dirnhofer, Richard

    2007-03-01

    The aim of the VIRTOPSY project () is utilizing radiological scanning to push low-tech documentation and autopsy procedures in a world of high-tech medicine in order to improve scientific value, to increase significance and quality in the forensic field. The term VIRTOPSY was created from the terms virtual and autopsy: Virtual is derived from the Latin word 'virtus', which means 'useful, efficient and good'. Autopsy is a combination of the old Greek terms 'autos' (=self) and 'opsomei' (=I will see). Thus autopsy means 'to see with ones own eyes'. Because our goal was to eliminate the subjectivity of "autos", we merged the two terms virtual and autopsy - deleting "autos" - to create VIRTOPSY. Today the project VIRTOPSY combining the research topics under one scientific umbrella, is characterized by a trans-disciplinary research approach that combines Forensic Medicine, Pathology, Radiology, Image Processing, Physics, and Biomechanics to an international scientific network. The paper will give an overview of the Virtopsy change process in forensic medicine.

  14. Pneumonia: Features registered in autopsy material.

    Science.gov (United States)

    Kosjerina, Zdravko; Vukoja, Marija; Vuckovic, Dejan; Kosjerina Ostric, Vesna; Jevtic, Marija

    2017-08-01

    Despite improvements in clinical practice, pneumonia remains one of the leading causes of death worldwide. Pathologic findings from autopsy reports could provide more precise and valid data on characteristics of pneumonia patients. We retrospectively reviewed autopsy reports of deceased patients admitted to the Institute for Pulmonary Diseases of Vojvodina in Sremska Kamenica, Serbia, between 1994 and 2003. The patients were classified into two groups: group 1 (n = 161) comprised patients in whom pneumonia was the main cause of death, while group 2 (n = 165) consisted of patients in whom pneumonia was confirmed at autopsy but had various different causes of death. From 1776 patients who underwent autopsy 326 (18.3%) were diagnosed with pneumonia. The most common underlying diseases were atherosclerosis (29.4%), chronic obstructive pulmonary disease (COPD) (26.7%), and malignancies (20.2%). Pneumonia was the main cause of death in 161 cases (group 1) while in group 2 major causes of death were heart failure (HF) (26.7%), acute myocardial infarction (AMI) (16.4%), and pulmonary embolism (PE) (10.9%). Multilobar involvement (91% vs.27%), pulmonary effusion (29% vs.14%), and lung abscess (23.6% vs.8.5%) were more frequently found in group 1, compared to group 2. In patients with pneumonia who underwent autopsy most common underlying diseases were atherosclerosis, COPD, and malignancies, while major causes of death were: progression of pneumonia, HF, AMI, and PE.

  15. Virtual autopsy as an alternative to traditional medical autopsy in the intensive care unit: a prospective cohort study.

    Science.gov (United States)

    Wichmann, Dominic; Obbelode, Frieder; Vogel, Hermann; Hoepker, Wilhelm Wolfgang; Nierhaus, Axel; Braune, Stephan; Sauter, Guido; Pueschel, Klaus; Kluge, Stefan

    2012-01-17

    Autopsy is an important educational and quality-control tool in the intensive care unit (ICU), but rates of traditional medical autopsies have declined worldwide. "Virtual" autopsy involving only advanced radiographic techniques might provide an alternative approach to postmortem examinations. To assess the value of postmortem multidetector computed tomography as an alternative to medical autopsy. Prospective cohort study. (ClinicalTrials.gov registration number: NCT01040520) 9 ICUs in a single academic medical center. Consent for both medical and virtual autopsies was sought from the families of all consecutive patients who died in the ICU between 1 January and 30 June 2010. Clinical records were reviewed to determine whether unsuspected autopsy findings would have altered care if known (major diagnosis) or would not have altered care (minor diagnosis). Of 285 patients, 47 underwent both virtual and medical autopsy. Of 196 clinical diagnoses made before death, 173 (88%) were identified by virtual autopsy and 183 (93%) by medical autopsy. Fourteen new major and 88 new minor diagnoses were detected by any autopsy method. The main diagnoses missed by virtual autopsy were cardiovascular events (9 of 72) and cancer (12 of 30). In contrast, medical autopsy missed 13 traumatic fractures and 2 pneumothoraces. Among 115 additional patients in whom only virtual autopsy was performed, 11 new major diagnoses were made. Virtual autopsy was performed in only 57% of patients (n = 162); among this group, consent for traditional medical autopsy was obtained for only one third. Virtual autopsy may be useful for identifying diagnoses that traditionally have been identified by medical autopsy. This may also hold true, at least in part, for the educational aspect of medical autopsy (confirming antemortem clinical diagnoses). Further studies are required to confirm these preliminary results. University Medical Center Hamburg-Eppendorf, Germany.

  16. Amniotic Fluid Aspiration in Medicolegal Autopsies

    Directory of Open Access Journals (Sweden)

    Sermet Koç

    1999-04-01

    Full Text Available Amniotic fluid aspiration occurs due to intrauterine anoxia. Being one of the causes of respiratory insufficiency and death in newborns, it can be diagnosed solely by histopathological examination. In the present paper, 12 cases with the diagnosis of amniotic fluid aspiration in autopsies between 1996-1997 in the mortuary section of the Council of Forensic Medicine are reevaluated from the medicolegal point of view. In the majority of the cases, delivery took place in locations other than hospitals, and the lack of medical intervention has been an important factor for the infavorable outcome of the autopsies. Findings of amniotic fluid aspiration stained with meconium were detected in four cases. Key words: Amniotic fluid aspiration, intrauterin asphyxia, Neonatal death, Medicolegal autopsy.

  17. Autopsy and medical education: a review.

    Science.gov (United States)

    Charlton, R

    1994-04-01

    During the twentieth century there has been a decline in the rate of autopsies performed. A review of the literature reveals reasons for this decline which include: an improvement in the medical diagnostic technology available; inadequate training of doctors as to the importance of autopsy; and difficulties in obtaining consent from relatives and the present use of audit. Recommendations for changes in medical education are made which include: a greater appreciation of the procedure as a useful investigation tool; the development of attitudes towards death; and improving communication skills with the bereaved. Recommendations are also made regarding education of the public, awareness of differences in cultural attitudes, the role of leaflets, the post-autopsy conference and the place of audit.

  18. Attitude of nigerian resident doctors towards clinical autopsy.

    Science.gov (United States)

    Ekanem, V J; Gerry, I E

    2007-03-01

    It is to the disadvantage of the doctors in training that there is a decline in the rate of clinical autopsy world wide. This decline may to an extent depend on the attitude of the physicians. To evaluate the attitude of resident doctors towards the practice of clinical autopsy and to determine their role in the decline of clinical autopsy. We carried out a survey of the attitude of resident doctors undergoing training in the various clinical departments of our teaching hospital towards clinical autopsy practice. This survey was by means of a structured randomly distributed questionnaire. Questions were asked on their willingness to request for autopsy, the number of autopsies that they have requested for so far, what hinders them from requesting for autopsy, the level of participation at autopsy and the importance of autopsies in the health care delivery system Eighteen (30%) out of 60 resident doctors attributed their inability to request for autopsy on their not being in direct control of the patients, while 16 (26.7%) found it difficult to get consent from the relatives. Seventeen per cent of them gave reason of not being able to obtain report from the pathologist, 13.3% said it was difficult to get pathologist to perform autopsy on time while only 11% said they knew the diagnosis in most of their cases. Almost all the resident doctors (98.5%) agreed that autopsy is a necessary procedure and is important for their training and health care delivery system Autopsy rate can increase if the resident doctors receive more blessings to request for autopsy from their consultants. Increased exposure to autopsies and education with regards to the benefits of autopsies at both the undergraduate and post graduate level will contribute to improvement in the rate of clinical autopsy.

  19. Cogeneration and North Carolina

    Energy Technology Data Exchange (ETDEWEB)

    Kohl, J. [ed.

    1979-01-01

    A separate abstract was prepared for each of 18 individual presentations. Appendices include lists of participants, speakers, and session chairmen plus California and North Carolina reports and legislation dealing with cogeneration.

  20. Unexpected brain finding in pre-autopsy postmortem CT.

    Science.gov (United States)

    Chatzaraki, Vasiliki; Bolliger, Stephan A; Thali, Michael J; Eggert, Sebastian; Ruder, Thomas D

    2017-09-01

    A case is presented in which pre-autopsy postmortem computed tomography (PMCT) revealed an unexpected brain abscess with a related frontal sinusitis and an erosion of the posterior wall of the frontal sinus. PMCT findings enabled the forensic pathologists to adapt protective measures during autopsy and protect their health from infection. Pre-autopsy PMCT has been also useful in the early differential diagnosis procedure. The complementary use of postmortem imaging and autopsy can improve the quality of forensic death investigations.

  1. [The evolution of autopsy technique--from Virchow to Virtopsy].

    Science.gov (United States)

    Skowronek, Rafał; Chowaniec, Czesław

    2010-01-01

    The autopsy technique evolves with extending knowledge and technical and technological progress in medical sciences. The objective of this report is to present the main autopsy techniques and an outline of transformations that occurred in the methodology of post mortem examinations with a focus on the Polish literature. Additionally, we present examples of paintings inspired by autopsy.

  2. Autopsy rates in the Netherlands: 35 years of decline

    NARCIS (Netherlands)

    B.M. Blokker. (Britt M.); A.C. Weustink (Annick); M.G.M. Hunink (Myriam); Oosterhuis, J.W. (J. Wolter)

    2017-01-01

    textabstractObjective: Although the autopsy still is a valuable tool in health statistics, health care quality control, medical education, and biomedical research, autopsy rates have been declining worldwide. The aim of this study was to examine trends of overall, clinical and forensic autopsy rates

  3. Autopsy after transcatheter aortic valve implantation

    DEFF Research Database (Denmark)

    van Kesteren, F; Wiegerinck, E M A; Rizzo, S

    2017-01-01

    Autopsy after transcatheter aortic valve implantation (TAVI) is a new field of interest in cardiovascular pathology. To identify the cause of death, it is important to be familiar with specific findings related to the time interval between the procedure and death. We aimed to provide an overview ...

  4. Autopsy prevalence of Wernicke's encephalopathy in alcohol ...

    African Journals Online (AJOL)

    Autopsy prevalence of Wernicke's encephalopathy in alcohol-related disease. ... The histological lesions were classified as either acute (5l, acute on chronic (9) or chronic (3) according to defined pathological criteria Macroscopic abnormalities were not obvious in any of the patients in the study group. Chart analysis ...

  5. 77 FR 38179 - Autopsies at VA Expense

    Science.gov (United States)

    2012-06-27

    ... clarifying language allows for ease of interpretation of the methods used to obtain consent for autopsy. In a... language will help to achieve this goal by clarifying which laws to consult, addressing the requirements... Nursing Home Care; 64.018, Sharing Specialized Medical Resources; 64.019, Veterans Rehabilitation Alcohol...

  6. Critical Issues in Psychological Autopsy Studies

    Science.gov (United States)

    Pouliot, Louise; De Leo, Diego

    2006-01-01

    This paper reviews research based on the psychological autopsy (PA) method applied to the study of suicide. It evidences the presence of a number of methodological problems. Shortcomings concern sampling biases in the selection of control subjects, confounding influences of extraneous variables, and reliability of the assessment instruments. The…

  7. Left Paraduodenal Hernia: An Autopsy Case

    DEFF Research Database (Denmark)

    Omland, Silje Haukali; Hougen, Hans Petter

    2011-01-01

    We present a case of a left paraduodenal hernia diagnosed at autopsy. A left paraduodenal hernia is an internal hernia of congenital origin due to the abnormal rotation of the midgut during embryonic development. Internal hernias are a rare cause of intestinal obstruction, with the paraduodenal...

  8. Library Programs in North Carolina

    Data.gov (United States)

    Town of Chapel Hill, North Carolina — Count of programs offered and program attendance numbers at public libraries in North CarolinaData is from the 2014-15 NC Statistical Report of NC Public Libraries:...

  9. [An autopsy case of the Reye's syndrome].

    Science.gov (United States)

    Kubo, S; Orihara, Y; Tsuda, R; Hirose, W; Matsumoto, H; Kita, T; Tanaka, N; Nakasono, I

    1996-12-01

    A case of sudden unexpected natural death in a 6-year-old girl was reported. She was found in dead with vomiting on her bed in the morning on 24. December. Autopsy did not reveal any injuries and abnormalities on her appearance. Small amount of light yellowish mucus in her nose, trachea and bronchus was found. Brain was slightly edematous (1395 g in weight). Liver was 750 g in weight and focal yellowish lesions were observed on its cut surfaces. Microscopically fatty degeneration (granulous fatty deposits) was observed in hepatocytes. Immunohistochemical staining of mitochondria in heart showed no staining microscopically, and degeneration and breakdown of mitochondria were found electromicroscopically. From the results of autopsy and histopathological findings, her cause of death was diagnosed as the Reye's syndrome.

  10. Can postmortem fetal MR imaging replace autopsy?

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Jeong Yeon; Song, Mi Jin [Sungkyunkwan Univ. School of Medicine, Seoul (Korea, Republic of); Kim, Seoung Hyup [Seoul National Univ. College of Medicine, Seoul (Korea, Republic of)

    2001-02-01

    The purposes of this study were to compare postmortem fetal MRI findings with autopsy findings and to assess whether postmortem MRI can replace autopsy. The study group consisted of 13 stillborn fetuses, seven that died immediately after birth, and five terminated because of anomalies seen on prenatal sonograms. A total 17 were male, and eight were female, and their gestational ages were from 20 to 41 (average;28.2) weeks. Spin-echo T1-and T2-weighted axial, sagittal, and coronal MR images were obtained, and autopsy findings were divided into major and minor. A major finding was defined as an anomaly or syndrome which caused fetal death or termination of the pregnancy: minor findings were classified, on the basis of gross inspection, as internal or external. MR images were retrospectively analyzed by two radiologists unaware of the autopsy findings, and by comparison with these, the postmortem MRI detection rates for major and minor findings was then determined. In seven of 25 fetuses, MR imaging revealed major findings, a dietction rate of 100%. There were two cases of anencephaly, two of trisomy-18, and one each of hydrops fetalis with large cystic hygroma, diaphragmatic hernia, and Dandy-Walker malformation. Twenty-three of 60 minor findings (38.3%) were detected by MRI. The detection rates for external and internal findings were 29.6%(8/27) and 45.5%(15/33), respectively. Although a limitation of our study is the low detection rate for minor findings, postmortem fetal MRI may help diagnose the major cause of fetal death.

  11. Radiographic investigations during medico-legal autopsies

    Energy Technology Data Exchange (ETDEWEB)

    Bratzke, H.; Schneider, V.; Dietz, W.

    1982-04-01

    During the last 13 years (1968-1980), 427 radiographic examinations were carried out during the course of medico-legal autopsies at the Institute of Forensic Medicine at the Free University of Berlin. Important problems were the demonstration of retained foreign bodies resulting from shooting, stabbing or blunt trauma, bone injuries, identification, and the question of life in neonates. An historical survey is given and 12 cases with special forensic problems are illustrated and discussed, and further means of investigations are described.

  12. Fatal poisoning in Jamaica: a coroner's autopsy study from the University Hospital of the West Indies.

    Science.gov (United States)

    Escoffery, Carlos T; Shirley, Suzanne E

    2004-04-01

    This study reviewed cases of fatal poisoning in a coroner's autopsy series at the University Hospital of the West Indies and represented the first such study reported from Jamaica. The autopsy protocols of all coroner's autopsies performed over the 20-year period January 1980 to December 1999 were reviewed retrospectively; 22 (1.0%) cases were identified and relevant clinical and pathological data analysed. There were 13 males and nine females (M:F ratio 1.4:1) with an age range of 2 - 69 years (mean +/- SD = 27 +/- 16.1 years). The 20 - 29 year group was most commonly affected and five patients (22.7%) were children (ackee were each implicated in two (9%) cases. The manner of death was suicidal in 14 (64%) cases and accidental in eight (36%) cases. Seven patients had documented psychiatric illnesses, six of whom committed suicide. Autopsy findings were largely non-specific. The relatively small number of cases was consistent with the low incidence of fatal poisoning in Jamaica.

  13. Single umbilical artery and associated malformations in over 5500 autopsies: relevance for perinatal management.

    Science.gov (United States)

    Rittler, Monica; Mazzitelli, Nancy; Fuksman, Rosa; de Rosa, Laura García; Grandi, Carlos

    2010-01-01

    With a birth prevalence rate of about 1%, single umbilical artery (SUA) is the most frequent of all congenital anomalies. It is recognizably associated with a variety of birth defects, but disagreement exists as to whether a SUA can predict an adverse perinatal outcome; disagreement also exists related to if, when present, other birth defects should be ruled out. The aims of the study were to estimate the association between SUA and other birth defects in a series of perinatal autopsies, to establish if preferential associations between SUA and certain birth defects exist, and to quantify the risks for other birth defects when a SUA is diagnosed. In a series of 5539 perinatal autopsies conducted at the Hospital Materno Infantil Ramón Sardá and the Private Laboratory of Perinatal Pathology, Buenos Aires, Argentina, the rate of each malformation (grouped by organ/system) associated with SUA and the risks of associated malformations were estimated. In this series of autopsies, the rate of SUA showed a 10-fold increase when other malformations were present. The risk for other malformations increased significantly, by a 3-fold to 9-fold measure, when a SUA was present. Urinary and gut anomalies showed a preferential association with SUA. The absence of other birth defects lowered the risk of chromosome anomalies associated with SUA in 56% (odds ratio  =  0.44). These results, obtained from a series of perinatal autopsies, are in agreement with most observations found in the literature, namely, high association rates between SUA and urinary and cardiovascular anomalies as well as a low risk for chromosome anomalies in SUA cases without other malformations.

  14. Minimally invasive, imaging guided virtual autopsy compared to conventional autopsy in foetal, newborn and infant cases: study protocol for the paediatric virtual autopsy trial.

    Science.gov (United States)

    Rüegger, Christoph M; Bartsch, Christine; Martinez, Rosa Maria; Ross, Steffen; Bolliger, Stephan A; Koller, Brigitte; Held, Leonhard; Bruder, Elisabeth; Bode, Peter Karl; Caduff, Rosmarie; Frey, Bernhard; Schäffer, Leonhard; Bucher, Hans Ulrich

    2014-01-20

    In light of declining autopsy rates around the world, post-mortem MR imaging is a promising alternative to conventional autopsy in the investigation of infant death. A major drawback of this non-invasive autopsy approach is the fact that histopathological and microbiological examination of the tissue is not possible. The objective of this prospective study is to compare the performance of minimally invasive, virtual autopsy, including CT-guided biopsy, with conventional autopsy procedures in a paediatric population. Foetuses, newborns and infants that are referred for autopsy at three different institutions associated with the University of Zurich will be eligible for recruitment. All bodies will be examined with a commercial CT and a 3 Tesla MRI scanner, masked to the results of conventional autopsy. After cross-sectional imaging, CT-guided tissue sampling will be performed by a multifunctional robotic system (Virtobot) allowing for automated post-mortem biopsies. Virtual autopsy results will be classified with regards to the likely final diagnosis and major pathological findings and compared to the results of conventional autopsy, which remains the diagnostic gold standard. There is an urgent need for the development of alternative post-mortem examination methods, not only as a counselling tool for families and as a quality control measure for clinical diagnosis and treatment but also as an instrument to advance medical knowledge and clinical practice. This interdisciplinary study will determine whether virtual autopsy will narrow the gap in information between non-invasive and traditional autopsy procedures. ClinicalTrials.gov: NCT01888380.

  15. Singh's verbal autopsy questionnaire for the assessment of causes of death, social autopsy, tobacco autopsy and dietary autopsy, based on medical records and interview.

    Science.gov (United States)

    Singh, Ram B; Fedacko, Jan; Vargova, Viola; Kumar, Adarsh; Mohan, Varun; Pella, Daniel; De Meester, Fabien; Wilson, Douglas

    2011-08-01

    The exact causes of death in India are not known because autopsy studies are difficult to conduct due to religious considerations. There are rapid changes in diet and lifestyle amongst social classes causing changes in the pattern of risk factors and mortality. In the present study, we attempt to develop a verbal autopsy questionnaire based on medical records and interview of a family member, for the assessment of causes of death, social class, tobacco consumption and dietary intakes among urban decedents in north India. For the period 1999-2001, we studied the randomly selected records of death of 2222 (1385 men and 837 women) decedents, aged 25-64 years, out of 3034 death records overall from the records at the Municipal Corporation, Moradabad. Families of these decedents were contacted individually to find out the causes of death, by scientist- administered, informed-consented, verbal autopsy questionnaire, completed with the help of the spouse and local treating doctor practicing in the appropriate health care region. Clinical data and causes of death were assessed by a questionnaire based on available hospital records and a modified WHO verbal autopsy questionnaire. Dietary intakes of the dead individuals were estimated by finding out the food intake of the spouse from 3-day dietary diaries and by asking probing questions about differences in food intake by the decedents. Tobacco consumption of the victim was studied by a questionnaire administered to family members. Social classes were assessed by a questionnaire based on attributes of per capita income, occupation, education, housing and ownership of consumer luxury items in the household. The diagnoses of overweight and obesity were based on the new WHO and International College of Nutrition criteria. Cardiac diseases (23.4%, n = 520) including coronary artery disease (10%), valvular heart disease (7.2%, n = 160), diabetic heart disease (2.2%, n = 49), sudden cardiac death and inflammatory cardiac disease

  16. Indians of North Carolina.

    Science.gov (United States)

    Bureau of Indian Affairs (Dept. of Interior), Washington, DC.

    A brief historical review of the Cherokee Indians from the mid-sixteenth century to modern day depicts an industrious tribe adversely affected by the settlement movement only to make exceptional economic advancements with the aid of the Bureau of Indian Affairs. Civic pride and self-leadership among the Cherokee Indians in North Carolina has…

  17. Carolinas Communication Annual, 1998.

    Science.gov (United States)

    McLennan, David B.

    1998-01-01

    This 1998 issue of "Carolinas Communication Annual" contains the following articles: "Give Me That Old Time Religion?: A Study of Religious Themes in the Rhetoric of the Ku Klux Klan" (John S. Seiter); "The Three Stooges versus the Third Reich" (Roy Schwartzman); "Interdisciplinary Team Teaching: Implementing…

  18. Remote autopsy services: A feasibility study on nine cases.

    Science.gov (United States)

    Vodovnik, Aleksandar; Aghdam, Mohammad Reza F; Espedal, Dan Gøran

    2017-01-01

    Introduction We have conducted a feasibility study on remote autopsy services in order to increase the flexibility of the service with benefits for teaching and interdepartmental collaboration. Methods Three senior staff pathologists, one senior autopsy technician and one junior resident participated in the study. Nine autopsies were performed by the autopsy technician or resident, supervised by the primary pathologist, through the secure, double encrypted video link using Jabber Video (Cisco) with a high-speed broadband connection. The primary pathologist and autopsy room each connected to the secure virtual meeting room using 14″ laptops with in-built cameras (Hewlett-Packard). A portable high-definition web camera (Cisco) was used in the autopsy room. Primary and secondary pathologists independently interpreted and later compared gross findings for the purpose of quality assurance. The video was streamed live only during consultations and interpretation. A satisfaction survey on technical and professional aspects of the study was conducted. Results Independent interpretations of gross findings between primary and secondary pathologists yielded full agreement. A definite cause of death in one complex autopsy was determined following discussions between pathologists and reviews of the clinical notes. Our satisfaction level with the technical and professional aspects of the study was 87% and 97%, respectively. Discussion Remote autopsy services are found to be feasible in the hands of experienced staff, with increased flexibility and interest of autopsy technicians in the service as a result.

  19. The perinatal autopsy: pertinent issues in multicultural Western Europe.

    Science.gov (United States)

    Gordijn, Sanne J; Erwich, Jan Jaap H M; Khong, T Yee

    2007-05-01

    Western Europe is in a demographic transition with increasing multicultural societies. Health professionals have to understand the background, religious and cultural aspects of parents to counsel them regarding an autopsy in the event of a perinatal loss. Autopsy rates have declined over the past decades, the major limiting factor being the granting of permission for an autopsy, possibly because of adverse publicity or reluctance of doctors to obtain consent. Autopsy has proved its value in revealing unsuspected findings. The public can be convinced of this utility by means of good information notwithstanding their religious or cultural background.

  20. Autopsies of the real: Resurrecting the dead

    OpenAIRE

    Valis, Noël

    2011-01-01

    The sense of the real, or the material—the dead body—as an inextricable part of the sacred does not disappear in the secular environment of the nineteenth and twentieth centuries. This article analyzes specific humanitarian narratives centered on the practice of autopsy and mummification, in which the traces of Catholicism act as a kind of spectral discourse of the imagination, where the real is configured in forms of the uncanny, the monstrous or the sacred.

    El sentido de ...

  1. Psychological Autopsy: A Psychobiographical Exploration of Suicide

    Directory of Open Access Journals (Sweden)

    José Alonso Andrade Salazar

    2013-06-01

    Full Text Available The present work is a conceptual approach on psychosocial factors related to suicidal psychobiography from the exploration of the lives of people who self-eliminate, for which there will be a review of the literature, based on input from journal articles and books published in various sources of documentation. Autopsy psychology is a data collection method that provides light on the psychosocial motivations that drive and reinforce the act of suicide, and is currently used by professionals responsible for investigating the causes of suicide while contributing data produced in the developing programs to promote mental health and prevention of suicidal ideation and behavior.

  2. Postmortem magnetic resonance imaging: Reproducing typical autopsy heart measurements.

    Science.gov (United States)

    Ampanozi, Garyfalia; Hatch, Gary M; Flach, Patricia M; Thali, Michael J; Ruder, Thomas D

    2015-11-01

    The aim of this study was to evaluate the utility of cardiac postmortem magnetic resonance (PMMR) to perform routine measurements of the ventricular wall thicknesses and the heart valves and to assess if imaging measurements are consistent with traditional autopsy measurements. In this retrospective study, 25 cases with cardiac PMMR and subsequent autopsy were included. The thicknesses of the myocardial walls as well as the circumferences of all heart valves were measured on cardiac PMMR and compared to autopsy measurements. Paired samples T-test and the Wilcoxon-Signed rank test, were used to compare autopsy and cardiac PMMR measurements. For exploring correlations, the Pearson's Correlation coefficient and the Spearman's Rho test were used. Cardiac PMMR measurements of the aortic and pulmonary valve circumferences showed no significant differences from autopsy measurements. The mitral and tricuspid valves circumferences differed significantly from autopsy measurements. Left myocardial and right myocardial wall thickness also differed significantly from autopsy measurements. Left and right myocardial wall thickness, and tricuspid valve circumference measurements on cardiac PMMR and autopsy, correlated strongly and significantly. Several PMMR measurements of cardiac parameters differ significantly from corresponding autopsy measurements. However, there is a strong correlation between cardiac PMMR measurements and autopsy measurements in the majority of these parameters. It is important to note that myocardial walls are thicker when measured in situ on cardiac PMMR than when measured at autopsy. Investigators using post-mortem MR should be aware of these differences in order to avoid false diagnoses of cardiac pathology based on cardiac PMMR. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  3. Molecular autopsy in victims of inherited arrhythmias.

    Science.gov (United States)

    Semsarian, Christopher; Ingles, Jodie

    2016-10-01

    Sudden cardiac death (SCD) is a rare but devastating complication of a number of underlying cardiovascular diseases. While coronary artery disease and acute myocardial infarction are the most common causes of SCD in older populations, inherited cardiac disorders comprise a substantial proportion of SCD cases aged less than 40 years. Inherited cardiac disorders include primary inherited arrhythmogenic disorders such as familial long QT syndrome (LQTS), Brugada syndrome (BrS), catecholaminergic polymorphic ventricular tachycardia (CPVT), and inherited cardiomyopathies, most commonly hypertrophic cardiomyopathy (HCM). In up to 40% of young SCD victims (defined as 1-40 years old, excluding sudden unexplained death in infancy from 0 to 1 years, referred to as SIDS), no cause of death is identified at postmortem [so-called "autopsy negative" or "sudden arrhythmic death syndrome" (SADS)]. Management of families following a SCD includes the identification of the cause of death, based either on premorbid clinical details or the pathological findings at the postmortem. When no cause of death is identified, genetic testing of DNA extracted from postmortem tissue (the molecular autopsy) may identify a cause of death in up to 30% of SADS cases. Targeted clinical testing in a specialized multidisciplinary clinic in surviving family members combined with the results from genetic testing, provide the optimal setting for the identification of relatives who may be at risk of having the same inherited heart disease and are therefore also predisposed to an increased risk of SCD.

  4. [Verbal autopsy in cervico-uterine cancer].

    Science.gov (United States)

    Chávez-García, Víctor Manuel; Zonana-Nacach, Abraham; Duarte, María Eugenia

    2007-01-01

    Verbal autopsy (VA) is a standardized method for investigating causes of death. Currently, the Mexican Ministry of Health uses officially VA to reconstruct the history of women who died of cervical cancer. to describe the findings of the VA of dead women due to cervical cancer in Tijuana, Baja California, Mexico. All death certificates issued in the years 2001 and 2001 in which cervical cancer was the main cause of death were reviewed. The VA included forty-five questions exploring six domains: subjects' personal information, sociodemographic characteristics, history of the disease, timely medical care, risk factors, affiliation to social security, and information registered in the death certificate. Seventy-nine women out of 97 had VA. The mean age was 54 years; 33% completed elementary school; 32% had smoking history; 50% had more than five pregnancies; 42% started sexual activity before the age of 17, 52% had had 2 to 3 sexual partners. 60% had Papanicolau test; 90% knew about their condition; 86% received medical care and 34% knew they had cancer one year before death. Verbal autopsy revealed that 40% of women who died of cervical cancer did not have Papanicolau test before being diagnosed.

  5. Molecular autopsy in victims of inherited arrhythmias

    Directory of Open Access Journals (Sweden)

    Christopher Semsarian, MBBS, PhD, MPH

    2016-10-01

    Full Text Available Sudden cardiac death (SCD is a rare but devastating complication of a number of underlying cardiovascular diseases. While coronary artery disease and acute myocardial infarction are the most common causes of SCD in older populations, inherited cardiac disorders comprise a substantial proportion of SCD cases aged less than 40 years. Inherited cardiac disorders include primary inherited arrhythmogenic disorders such as familial long QT syndrome (LQTS, Brugada syndrome (BrS, catecholaminergic polymorphic ventricular tachycardia (CPVT, and inherited cardiomyopathies, most commonly hypertrophic cardiomyopathy (HCM. In up to 40% of young SCD victims (defined as 1–40 years old, excluding sudden unexplained death in infancy from 0 to 1 years, referred to as SIDS, no cause of death is identified at postmortem [so-called “autopsy negative” or “sudden arrhythmic death syndrome” (SADS]. Management of families following a SCD includes the identification of the cause of death, based either on premorbid clinical details or the pathological findings at the postmortem. When no cause of death is identified, genetic testing of DNA extracted from postmortem tissue (the molecular autopsy may identify a cause of death in up to 30% of SADS cases. Targeted clinical testing in a specialized multidisciplinary clinic in surviving family members combined with the results from genetic testing, provide the optimal setting for the identification of relatives who may be at risk of having the same inherited heart disease and are therefore also predisposed to an increased risk of SCD.

  6. Emergency medicine techniques and the forensic autopsy.

    Science.gov (United States)

    Buschmann, Claas; Schulz, Thomas; Tsokos, Michael; Kleber, Christian

    2013-03-01

    Emergency medicine measures often have to be carried out under suboptimal conditions in emergency situations and require invasive patient treatment. In the case of a fatal outcome these measures have to be evaluated at autopsy, regarding indications, correct implementation and possible complications. As well, alongside the more familiar procedures--such as endotracheal intubation, insertion of chest drains, external cardiac massage and cannulation of central and peripheral veins--there are alternative techniques being increasingly applied, that include new tools for the management of hemorrhagic shock, drug delivery and alternative airway management devices. On the one hand, all of these measures are essential for the survival and appropriate treatment of the injured and/or sick patient, but on the other hand they can damage the patient and thus contain a significant risk of both medical and forensic relevance for the patient and the physician. In the following review we provide an overview of established, new and alternative techniques for emergency airway management, administration of drugs and management of hemorrhagic shock. The aim is to facilitate the understanding and autopsy evaluation of current emergency medicine techniques.

  7. A retrospective study of paediatric medicolegal autopsies at the ...

    African Journals Online (AJOL)

    Medicolegal death is the term used to describe any violent, unclear or suspicious death that must be subjected to legal investigation. The aim of ... A total of 551 childhoods MLA were recorded during the period under review, accounting for 12.3% of all medicolegal autopsies and 96% of all paediatric autopsies. Of this total ...

  8. Autopsy pathology revisited | Offiah | Abia State University Medical ...

    African Journals Online (AJOL)

    An autopsy is the examination of the body of a dead person. · It involves systematic dissection of human tissue after death. · It may be restricted to a specific organ region of the body. · Autopsies are performed to determine the cause of death, for legal purposes, and for education and research. · The body is opened in a ...

  9. The Pattern and Frequency of Drowning Autopsies in Benin City ...

    African Journals Online (AJOL)

    Demographic data like age, sex and other variables like site of drowning, activity before drowning, manner of death and autopsy findings were collated and analyzed. Results: Among 1,022 medicolegal autopsies done during the period, 22 cases of drowning were seen giving a rate of 2.2%. The youngest victim was a year ...

  10. Medico Legal Autopsies In Aba, Nigeria | Offiah | Abia State ...

    African Journals Online (AJOL)

    To determine the pattern of medico legal autopsies performed between January 2001 to December 2005 so as to highlight any differences or similarities to the observation of workers in other parts of the country and/or world. A hospital based retrospective analysis of coroner's autopsies in Abia State University Teaching ...

  11. Medicolegal Autopsies In Port Harcourt, Nigeria | Etebu | Nigerian ...

    African Journals Online (AJOL)

    OBJECTIVE: This study was undertaken to determine the pattern of medicolegal autopsies to highlight any differences or similarities to the observations of workers in other parts of the country and abroad. METHOD: This study is a retrospective review of all medicolegal autopsies carried out at the University of Port Harcourt ...

  12. Attitude and Perceptions of Clinicians in Lagos to Autopsy Practice ...

    African Journals Online (AJOL)

    Attitude and Perceptions of Clinicians in Lagos to Autopsy Practice. ... The reasons for this delay include relegation of autopsy pathology as a surbodinate of research or surgical pathology and lack of motivation for the pathologist who is no longer compensated in any way that would encourage his effort. The study shows ...

  13. In Defense of Clinical Autopsy and Its Practice in Cuba.

    Science.gov (United States)

    Espinosa-Brito, Alfredo D; de Mendoza-Amat, José Hurtado

    2017-01-01

    There has been a notable decrease in the global practice of clinical autopsy; the rate has fallen to below 10%, even in high-income countries. This is attributed to several causes, including increased costs, overreliance on modern diagnostic techniques, cultural and religious factors, the emergence of new infectious diseases and negative attitudes on the part of doctors, even pathologists. Alternative methods to autopsy in postmortem studies have been developed based on imaging, endoscopy and biopsy (all quite expensive). These methods have been used in developed countries but never as effectively as the classic autopsy for identifying cause of death and potential medical errors. Although Cuba has also seen a decrease in its autopsy rates, they remain comparatively high. Between 1996 and 2015, there were 687,689 hospital deaths in Cuba and 381,193 autopsies, 55.4% of the total. These autopsies have positively affected medical care, training, research, innovation, management and society as a whole. Autopsies are an important tool in the National Health System's quest for safe, quality patient care based on the lessons learned from studying the deceased. KEYWORDS Autopsy, postmortem examination, postmortem diagnosis, quality of care, patient safety, medical error, Cuba.

  14. The perinatal autopsy : Pertinent issues in multicultural Western Europe

    NARCIS (Netherlands)

    Gordijn, Sanne J.; Erwich, Jan Jaap H. M.; Khong, T. Yee

    Western Europe is in a demographic transition with increasing multicultural societies. Health professionals have to understand the background, religious and cultural aspects of parents to counsel them regarding an autopsy in the event of a perinatal loss. Autopsy rates have declined over the past

  15. Pediatric medicolegal autopsy in France: A forensic histopathological approach.

    Science.gov (United States)

    Delteil, Clémence; Tuchtan, Lucile; Torrents, Julia; Capuani, Caroline; Piercecchi-Marti, Marie-Dominique

    2018-01-01

    The aim of postmortem medicolegal examination in pediatric death is primarily to establish the circumstances and causes of death and to exclude child abuse. In France, pediatric death is systematically documented by medicolegal or medical autopsy. In case of medicolegal autopsy, the complementary examinations, requested and financed by justice, are rarely limited to a histopathological examination. However in medical autopsies other tools are available to the pathologist as toxicology, biochemistry and molecular biology. The purpose of this article is to evaluate the efficacy of forensic histopathology in pediatric forensic autopsies. We analyze the main causes of pediatric death in a forensic context. Between 2004 and 2015, 157 infant deaths were identified in Marseille university hospital. The forensic histopathology and autopsy reports of all 157 cases were available for systematic review. Medical or surgical causes represented 41,3% of deaths in our center, accidental causes 8.1% and child abuse 28,8%. The definitive diagnosis was made at autopsy in 30% of cases and at histopathological examination in 70% highlighting that forensic histopathology is an indispensable tool in pediatric medicolegal autopsies. Significant histological abnormalities may be detected in selected organs such as the brain, lungs, heart, liver, adrenal glands and kidneys in spite of macroscopically normal appearances. This justifies systematic sampling of all organs. Despite the implementation of the French sudden infant death protocol which recommends medical autopsies, too many pediatric autopsies are carried out in a medicolegal context. 30% of the cases remain without diagnosis at the end of the autopsy and histological examination. This number could be reduced by the contribution of others laboratory investigation. Copyright © 2017 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  16. Autopsy causes of death in HIV-positive individuals in sub-Saharan Africa and correlation with clinical diagnoses.

    Science.gov (United States)

    Cox, Janneke A; Lukande, Robert L; Lucas, Sebastian; Nelson, Ann M; Van Marck, Eric; Colebunders, Robert

    2010-01-01

    Despite the persistently high HIV-related mortality in sub-Saharan Africa, limited information on the causes of death is available. Pathological autopsies are the gold standard to establish causes of death. In this review we describe the autopsy series performed among HIV-infected individuals in sub-Saharan Africa over the last two decades. We identified nine complete and 11 partial or minimally invasive autopsy series. Complete autopsies were performed in 593 HIV-positive adults and 177 HIV-positive children. Postmortem diagnoses were mainly infectious diseases. Tuberculosis was the most frequent, present in 21-54% of HIV-positive adults and was considered the cause of death in 32-45%. Overall, pulmonary infections accounted for approximately 66% of pathology and central nervous system infections for approximately 20%. A high discordance between clinical and postmortem diagnoses was observed. This review emphasizes the need for reliable information on causes of death in order to improve HIV patient care, guide further research, and inform health policy.

  17. Value of postmortem computed tomography in comparison to autopsy; Prospektive Untersuchung zur Wertigkeit der postmortalen Computertomographie im Vergleich zur Autopsie

    Energy Technology Data Exchange (ETDEWEB)

    Paperno, S.; Krug, B.; Lackner, L. [Klinik und Poliklinik fuer Radiologische Diagnostik, Univ. zu Koeln (Germany); Riepert, T.; Rothschild, M.A.; Schultes, A.; Staak, M. [Inst. fuer Rechtsmedizin des Klinikums der Univ. zu Koeln (Germany)

    2005-01-01

    Purpose: to assess the diagnostic value of postmortem computed tomography (CT) in comparison to autopsy. Materials and methods: twenty-seven cadavers were examined by sequential cranial CT and helical CT through the neck, thorax and abdomen and subsequently underwent an autopsy with histomorphologic examination of the pathologic specimens. The findings of CT, autopsy and histology were registered and compared by three radiologists and one specialist for forensic medicine, using a data entry form. Results: in 19 of 27 cases, the findings explaining the cause of death were concordant for CT and autopsy. Intracranial, intraspinal and intracardiac gas accumulations (n = 12) were registered by CT alone. The detection of skull fractures was equal for both methods (n = 3). CT showed diagnostic problems in the assessment of pneumonic infiltrations (n = 16) and pulmonary edema (n = 21). Conclusion: CT is a useful and complementary method to autopsy. (orig.)

  18. Art Renaissance in South Carolina.

    Science.gov (United States)

    Cross, Jim

    1990-01-01

    South Carolina's requirement that school districts identify and serve artistically gifted/talented students in grades 3-12 has led the State Department of Education to develop support activities, as establishing curriculum guidelines, showcasing successful programs, and creating leadership roles for the South Carolina Arts Commission and the…

  19. Myocardial bridges: a prospective forensic autopsy study.

    Science.gov (United States)

    Micić-Labudović, Jelena; Atanasijević, Tatjana; Popović, Vesna; Mihailović, Zoran; Nikolić, Slobodan; Puzović, Dragana

    2015-01-01

    When the coronary artery, located subepicardially, submerges into the myocardium and appears again subepicardially after a short intramural course, it represents an embedded coronary artery, while the part of the myocardium above is a myocardial bridge. We investigated the frequency of the embedded left coronary artery (LAD) in the autopsy material considering the descending branch of the LAD to be the most important one in the nourishment of the myocardium and myocardial bridges to be the most frequent in its area, as well as clinically important. A prospective autopsy study of 975 cases was performed, including both, natural (21.33%) and violent (78.67%) deaths. The sample consisted of 74.56% males and 25.44%females. In order to discover myocardyal bridges and their characteristics, the hearts were examined by both transverse cuts and longitudinal openings of the LAD. Myocardial bridge was found in 78 cases (8.00%), more commonly in males (9.35%) than females (4.03%).The average length of the myocardial bridge was 21.85±16.10mm and thickness 3.744±1.48 mm. The common localization of the myocardial bridge was the proximal half of the LAD (89.74%).The upper part of the artery, proximal to the bridge, was a common site of atherosclerotic changes. Myocardial bridge was found in 12.50% of natural deaths, but in 13.38% out of all cases of sudden cardiac deaths. Therefore, the presence of the myocardial bridge by itself is not predominant, but it is certainly a contributing factor to a sudden cardiac death.

  20. [Sudden cardiovascular death in adults: Study of 361 autopsy cases].

    Science.gov (United States)

    Mesrati, M A; Belhadj, M; Aissaoui, A; HajSalem, N; Oualha, D; Boughattas, M; Messaoudi, I; Hammedi, F; Zakhama, A; Chadly, A

    2017-02-01

    To describe epidemiological aspects of sudden cardiovascular death and to specify the etiopathogenic characteristics. Our study is retrospective and descriptive. It included 361 cases of sudden cardiovascular death, which underwent autopsy in forensic medicine department of Monastir during eight years, from 1st January 2004 to 31st December 2011. The incidence of sudden cardiovascular death was 9 per 100,000 person. A marked male predominance was noted. The mean age was 55.75 years. In our series, myocardial infarction represents the leading cause of sudden cardiovascular death, 57.8% of cases. Other etiologies were hypertrophic cardiomyopathy (4.7%), heart failure (1.9%), arrhythmogenic right ventricular dysplasia (2.8%), valvular disease (2%), cardio-myo-pericarditis (1.9%), hydatid cyst of the heart (0.8%), ruptured aneurysm (2.5%), pulmonary embolism (1.9%) and aortic dissection (1.3%). A sudden cardiovascular death at work was found in 25 cases. These cases pose essentially a problem of imputability. Sudden cardiac death is usually the complication of underlying heart disease, sometimes overlooked. Several risk factors are involved. Sudden cardiac death in healthy heart or death caused by arrhythmia is an important entity seeking the intervention of several actors (forensic doctor, cardiologist, geneticist, media…) for prevention. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  1. [Frequency of forensic autopsies after deaths in road traffic accidents].

    Science.gov (United States)

    Igeltjørn, Marit; Nordrum, Ivar Skjåk

    2009-09-24

    In 2007, 224 persons died in road traffic accidents in Norway. According to the instruction for prosecution, the police should request forensic autopsy in such deaths. The police's adherence to this instruction varies. The aim of this study was to document enforcement of the instruction for prosecution among police districts in two Norwegian counties (North and South Trøndelag). Data from forensic autopsies of deaths in road traffic accidents performed at The Department of Pathology and Medical Genetics at St. Olavs Hospital were compared with data from similar deaths in the two counties registered in The Cause of Deaths Statistics in Statistics Norway for the time period 1996-2005. 249 persons died in road traffic accidents in the two counties in the time period assessed; forensic autopsies were performed on 157 (63 %) of them. The forensic autopsy rate decreased from 69 % in the first 5-year period to 57 % in the second period. The largest decrease was in North Trøndelag where the rate dropped from 62 % to 38 %. Drivers of motorized vehicles were to a larger extent autopsied than other road-users; victims of motorcycle accidents were autopsied to a lesser extent than those of car accidents and other types of road traffic accidents. The reduced frequency of autopsy and differences in request practice between police districts may be explained by economical circumstances, different understanding of the importance of forensic autopsies and different interpretation of the instruction for prosecution. It is not known whether there were important differences between those who were autopsied and those who were not.

  2. Analysis of discrepancies between external body examination and forensic autopsy.

    Science.gov (United States)

    Lorin de la Grandmaison, Geoffroy; Fermanian, Christophe; Durigon, Michel

    2008-03-01

    At present in France, most of the medico-legal investigations are restricted to death scene investigation, which means there is only an external body examination without subsequent autopsy. The aim of our study was to show the limits of death scene investigation by establishing the rate of discrepancies between the results of external body examination and forensic autopsy.A retrospective study was carried out on 200 autopsy cases which were all preceded by death scene investigation and performed in 2002. For each case, age, sex, body weight, body state, place, and time of death were reported. The number of recent trauma lesions detectable at external body examination and at autopsy was studied. Conclusions about manner and cause of death between death scene investigation and autopsy were also studied. Discrepancy rate about interpretation of the lesions seen at external body examination and at autopsy was determined. Discrepancy between minor external trauma lesions and severe internal trauma lesions was also studied.The mean age of the studied population was 42.4 years. Sex ratio was 2.2. External body examination was limited by body state in 32% of the cases. The mean number of recent external trauma lesions recorded at autopsy was significantly higher than those recorded during death scene investigation. Manner and causes of death were undetermined after death scene investigation in 54.5% and 49% of the cases, respectively. When the cases were determined by death scene investigation, discrepancy rate, respectively, was 5% and 9% of all cases (n = 200) for manner and causes of death.Death scene investigation even carried out by a well-trained forensic physician is not reliable relative to cause and manner of death. Our study underlines the necessity in the future to perform more forensic autopsies in France, relying on the European harmonization of medico-legal autopsy rules.

  3. Carolinas Energy Career Center

    Energy Technology Data Exchange (ETDEWEB)

    Classens, Anver; Hooper, Dick; Johnson, Bruce

    2013-03-31

    Central Piedmont Community College (CPCC), located in Charlotte, North Carolina, established the Carolinas Energy Career Center (Center) - a comprehensive training entity to meet the dynamic needs of the Charlotte region's energy workforce. The Center provides training for high-demand careers in both conventional energy (fossil) and renewable energy (nuclear and solar technologies/energy efficiency). CPCC completed four tasks that will position the Center as a leading resource for energy career training in the Southeast: • Development and Pilot of a New Advanced Welding Curriculum, • Program Enhancement of Non-Destructive Examination (NDE) Technology, • Student Support through implementation of a model targeted toward Energy and STEM Careers to support student learning, • Project Management and Reporting. As a result of DOE funding support, CPCC achieved the following outcomes: • Increased capacity to serve and train students in emerging energy industry careers; • Developed new courses and curricula to support emerging energy industry careers; • Established new training/laboratory resources; • Generated a pool of highly qualified, technically skilled workers to support the growing energy industry sector.

  4. Computer-assisted virtual autopsy using surgical navigation techniques.

    Science.gov (United States)

    Ebert, Lars Christian; Ruder, Thomas D; Martinez, Rosa Maria; Flach, Patricia M; Schweitzer, Wolf; Thali, Michael J; Ampanozi, Garyfalia

    2015-01-01

    OBJECTIVE; Virtual autopsy methods, such as postmortem CT and MRI, are increasingly being used in forensic medicine. Forensic investigators with little to no training in diagnostic radiology and medical laypeople such as state's attorneys often find it difficult to understand the anatomic orientation of axial postmortem CT images. We present a computer-assisted system that permits postmortem CT datasets to be quickly and intuitively resliced in real time at the body to narrow the gap between radiologic imaging and autopsy. Our system is a potentially valuable tool for planning autopsies, showing findings to medical laypeople, and teaching CT anatomy, thus further closing the gap between radiology and forensic pathology.

  5. Detection of occult disease in tissue donors by routine autopsy.

    Science.gov (United States)

    Otero, J; Fresno, M F; Escudero, D; Seco, M; González, M; Peces, R

    1998-01-01

    The transmission of infectious and neoplastic diseases is a potential risk of tissue allografting. In this study, we analyzed the occurrence of occult disease in tissue donors as detected by standard screening and autopsy. Whereas 18% of the potential donors initially evaluated were eliminated on the basis of their medical and social histories, laboratory screening and autopsy revealed that an additional 9% of tissue donors had undetected, transmissible disease that prohibited tissue donation. This report emphasizes once again the risk of occult disease being transplanted with grafts and the need for autopsy to reduce the likelihood of this occurring. If donor selection, appropriate screening tests, and autopsy are carefully carried out, the risk of transmitting diseases from tissue allografts can be kept to a minimum.

  6. Autopsy rates in the Netherlands: 35 years of decline

    National Research Council Canada - National Science Library

    Blokker., Britt M; Weustink, Annick; Hunink, Myriam; Oosterhuis, J.W

    2017-01-01

    .... The aim of this study was to examine trends of overall, clinical and forensic autopsy rates among adults in the Netherlands over the last four decades, and trends per sex, age (groups), and hospital type. Methods...

  7. Medico Legal Autopsies In Aba, Nigeria | Offiah | Abia State ...

    African Journals Online (AJOL)

    %), accidents (16%), undetermined (12%) in that order. Only 2% of cases was suicide and were hanging. The above findings suggest that homicide is common in Aba. There is lack of proper documentation of coroner autopsies in Aba, ...

  8. The Significance of Subendocardial Hemorrhages Detected in Forensic Autopsies

    National Research Council Canada - National Science Library

    Nursel Türkmen Inanir; Selçuk Çetin; Filiz Eren; Bülent Eren

    2015-01-01

    .... Material and Method :285 autopsy cases diagnosed as SEH which were brought to the Group Presidency of Morgue Specialization Department of the State Institute of Forensic Medicine of Bursa were included in the study. Results...

  9. Usefulness of systematic histological examination in routine forensic autopsy.

    Science.gov (United States)

    de la Grandmaison, Geoffroy Lorin; Charlier, Philippe; Durigon, Michel

    2010-01-01

    The forensic community does not agree on the need to perform histological examination at forensic autopsy. The aim of our study was to determine the usefulness of systematic standard histology in forensic autopsies. A prospective study was carried out on 428 autopsy cases for which standard histological examination was systematic. Mechanism of death not shown by gross anatomic findings was discovered by histology in about 40% of the cases. Cause of death was established by only histology in 8.4% of the cases. Microscopic findings affected the manner of death in 13% of the cases. Histology provided complementary information about prior medical condition of the deceased in about 49% of the cases. Traumatic lesions were better documented by histology in about 22% of the cases. According to the results of our study, systematic standard histology for the main organs should be used in routine forensic autopsies.

  10. Improving Autopsy Report Turnaround Times by Implementing Lean Management Principles.

    Science.gov (United States)

    Cromwell, Susan; Chiasson, David A; Cassidy, Debra; Somers, Gino R

    2017-01-01

    The autopsy is an integral part of the service of a large academic pathology department. Timely reporting is central to providing good service and is beneficial for many stakeholders, including the families, the clinical team, the hospital, and the wider community. The current study aimed to improve hospital-consented autopsy reporting times (turnaround time, TAT) by using lean principles modified for a healthcare setting, with an aim of signing out 90% of autopsies in 90 days. An audit of current and historical TATs was performed, and a working group incorporating administrative, technical, and professional staff constructed a value stream map documenting the steps involved in constructing an autopsy report. Two areas of delay were noted: examination of the microscopy and time taken to sign-out the report after the weekly autopsy conference. Several measures were implemented to address these delays, including visual tracking using a whiteboard and individualized tracking sheets, weekly whiteboard huddles, and timelier scheduling of clinicopathologic conference rounds. All measures resulted in an improvement of TATs. In the 30 months prior to the institution of lean, 37% of autopsies (53/144) were signed out in 90 days, with a wide variation in reporting times. In the 30 months following the institution of lean, this improved to 74% (136/185) ( P < .0001, Fisher exact test), with a marked reduction in variability. Further, the time from autopsy to presentation at weekly clinicopathological rounds was also reduced (median: 73 days prior to lean; 63 days post-lean). The application of lean principles to autopsy sign-out workflow can significantly improve TATs and reduce variability, without changing staffing levels or significantly altering scheduling structure.

  11. Autopsies of the real: Resurrecting the dead

    Directory of Open Access Journals (Sweden)

    Valis, Noël

    2011-12-01

    Full Text Available The sense of the real, or the material—the dead body—as an inextricable part of the sacred does not disappear in the secular environment of the nineteenth and twentieth centuries. This article analyzes specific humanitarian narratives centered on the practice of autopsy and mummification, in which the traces of Catholicism act as a kind of spectral discourse of the imagination, where the real is configured in forms of the uncanny, the monstrous or the sacred.

    El sentido de lo real, de lo material —el cuerpo sin vida— como una inextricable parte de lo sagrado, no desaparece del ambiente secular de los siglos XIX y XX. En los relatos analizados en este artículo se estudia cómo en determinadas narrativas humanitarias centradas en la práctica de la autopsia y la momificación, las huellas del catolicismo actúan como una suerte de discurso espectral de la imaginación, en que lo real se configura en formas de lo siniestro, lo monstruoso o lo sagrado.

  12. Virtual autopsy: two- and three-dimensional multidetector CT findings in drowning with autopsy comparison.

    Science.gov (United States)

    Levy, Angela D; Harcke, H Theodore; Getz, John M; Mallak, Craig T; Caruso, James L; Pearse, Lisa; Frazier, Aletta A; Galvin, Jeffrey R

    2007-06-01

    To retrospectively determine the multidetector computed tomographic (CT) virtual autopsy findings of death by drowning in comparison with autopsy findings. The institutional review board of the Armed Forces Institute of Pathology approved this HIPAA-compliant study and did not require informed consent by the next of kin. Total-body multidetector CT was performed, immediately prior to routine autopsy, in 28 consecutive male subjects (mean age, 24.2 years) who died of drowning and a control group of 12 consecutive male subjects (mean age, 50.8 years) who died of sudden death from atherosclerotic coronary artery disease. Images were evaluated for the presence of fluid and sediment in the paranasal sinuses and airways, mastoid air cell fluid, frothy fluid in the airways, pulmonary opacity (ground-glass opacity or airspace consolidation), interlobular septal thickening, and gastric distention and contents (fluid or sediment). Image findings were compared with findings from autopsy reports and photographs. All drowning subjects had fluid in the paranasal sinuses and mastoid air cells and had ground-glass opacity within the lungs. Twenty-six subjects (93%) had fluid in the subglottic trachea and main bronchi. Fourteen subjects (50%) had high-attenuation sediment in the subglottic airways. Frothy fluid in the airways was present in six subjects (21%). Twenty-five (89%) of the drowning subjects had pulmonary ground-glass opacity with septal lines, which was mild with apical and perihilar distribution in 12 subjects, severe and diffuse in nine, posterior and basilar in three, and limited to the apices in one (not assessed in three of 28 subjects because of decomposition). Control subjects showed mastoid cell fluid (25%), sinus fluid (83%), subglottic airway fluid (92%), and pulmonary ground-glass opacity (100%) but did not have evidence of frothy airway fluid or high-attenuation sediment in the airways. The multidetector CT finding of frothy airway fluid or high

  13. Childhood neoplasms presenting at autopsy: A 20-year experience.

    Science.gov (United States)

    Bryant, Victoria A; Booth, John; Palm, Liina; Ashworth, Michael; Jacques, Thomas S; Sebire, Neil J

    2017-09-01

    The aims of the review are to establish the number of undiagnosed neoplasms presenting at autopsy in a single centre and to determine the incidence and most common causes of sudden unexpected death due to neoplasia in infancy and childhood (SUDNIC). Retrospective observational study of paediatric autopsies performed on behalf of Her Majesty's Coroner over a 20-year period (1996-2015; n = 2,432). Neoplasms first diagnosed at autopsy were identified from an established database and cases meeting the criteria for sudden unexpected death were further categorised. Thirteen previously undiagnosed neoplasms were identified, including five haematological malignancies, two medulloblastomas, two neuroblastomas, two cardiac tumours and two malignancies of renal origin. Eight cases met the criteria for SUDNIC (0.33% of autopsies), the commonest group of which were haematological malignancies (n = 3). Neoplasms presenting as unexpected death in infancy and childhood and diagnosed at autopsy are rare. The findings suggest that haematological malignancies are the commonest cause of SUDNIC and highlight the importance of specialist autopsy in cases of sudden unexpected death. © 2017 Wiley Periodicals, Inc.

  14. Whither North Carolina furniture manufacturing?

    OpenAIRE

    Robert L. Lacy

    2004-01-01

    North Carolina's furniture manufacturing industry has contracted in recent years as imports have gained a greater share of the domestic furniture market. Rapid growth of the furniture industry in China and a surge in exports from that country to the United States in particular have contributed to plant closings and consolidation of operations in the state. North Carolina's furniture manufacturers are adapting to the emergence of global competition and are developing new corporate strategies t...

  15. Virtual autopsy with multiphase postmortem computed tomographic angiography versus traditional medical autopsy to investigate unexpected deaths of hospitalized patients: a cohort study.

    Science.gov (United States)

    Wichmann, Dominic; Heinemann, Axel; Weinberg, Clemens; Vogel, Hermann; Hoepker, Wilhelm Wolfgang; Grabherr, Silke; Pueschel, Klaus; Kluge, Stefan

    2014-04-15

    "Virtual" autopsy by postmortem computed tomography (PMCT) can replace medical autopsy to a certain extent but has limitations for cardiovascular diseases. These limitations might be overcome by adding multiphase PMCT angiography. To compare virtual autopsy by multiphase PMCT angiography with medical autopsy. Prospective cohort study. (ClinicalTrials.gov: NCT01541995) SETTING: Single-center study at the University Medical Center Hamburg-Eppendorf, Hamburg, Germany, between 1 April 2012 and 31 March 2013. Hospitalized patients who died unexpectedly or within 48 hours of an event necessitating cardiopulmonary resuscitation. Diagnoses from clinical records were compared with findings from both types of autopsy. New diagnoses identified by autopsy were classified as major or minor, depending on whether they would have altered clinical management. Of 143 eligible patients, 50 (35%) had virtual and medical autopsy. Virtual autopsy confirmed 93% of all 336 diagnoses identified from antemortem medical records, and medical autopsy confirmed 80%. In addition, virtual and medical autopsy identified 16 new major and 238 new minor diagnoses. Seventy-three of the virtual autopsy diagnoses, including 32 cases of coronary artery stenosis, were identified solely by multiphase PMCT angiography. Of the 114 clinical diagnoses classified as cardiovascular, 110 were confirmed by virtual autopsy and 107 by medical autopsy. In 11 cases, multiphase PMCT angiography showed "unspecific filling defects," which were not reported by medical autopsy. These results come from a single center with concerted interest and expertise in postmortem imaging; further studies are thus needed for generalization. In cases of unexpected death, the addition of multiphase PMCT angiography increases the value of virtual autopsy, making it a feasible alternative for quality control and identification of diagnoses traditionally made by medical autopsy. University Medical Center Hamburg-Eppendorf.

  16. Two forensic autopsy cases of death due to upper gastrointestinal hemorrhage: a comparison of postmortem computed tomography and autopsy findings.

    Science.gov (United States)

    Suzuki, Hideto; Hasegawa, Iwao; Hoshino, Norio; Fukunaga, Tatsushige

    2015-05-01

    In this report, we describe two autopsy cases of death due to upper gastrointestinal hemorrhage (Case 1: gastric ulcer, Case 2: aortoduodenal fistula). Postmortem computed tomography (CT) images from both cases revealed pooling of gastric fluid, which contained high attenuation areas, although these images also mirrored the different sources of the gastrointestinal hemorrhage. Fluid collection was observed in the small intestine for both cases, although the high attenuation areas were only remarkable in Case 2. The autopsy in Case 1 revealed a peptic ulcer, with small vessels exposed on the surface of the ulcer. Melena was also observed throughout the intestine, although clotting was only observed inside the stomach. The autopsy in Case 2 revealed diffuse massive clotting from the stomach to the upper portion of the ileum, which was due to a primary aortoduodenal fistula. Given our autopsy findings, the extent of the high attenuation areas in the digestive tract during postmortem CT scanning may be correlated with the speed of the gastrointestinal hemorrhage before death. Carefully evaluating the radiodensity of the gastrointestinal contents during postmortem CT scanning may indicate the primary site of the hemorrhage before the autopsy, thereby facilitating the accurate identification of the cause of death during forensic autopsy. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  17. Clinical diagnosis versus autopsy diagnosis in head trauma

    Directory of Open Access Journals (Sweden)

    Velnic Andreea-Alexandra

    2017-12-01

    Full Text Available The correct and complete diagnosis is essential for the adequate care and the favourable clinical evolution of the patients with head trauma. Purpose: To identify the error rate in the clinical diagnosis of head injuries as shown in comparison with the autopsy diagnosis and to identify the most common sources of error. Material and method: We performed a retrospective study based on data from the medical files and the autopsy reports of patients with head trauma who died in the hospital and underwent forensic autopsy. We collected: demographic data, clinical and laboratory data and autopsy findings. To quantify the concordance rate between the clinical diagnosis of death and the autopsy diagnosis we used a 4 classes classification, which ranged from 100% concordance (C1 to total discordance (C4 and two classes of partial discordance: C2 (partial discordance in favour of the clinical diagnosis- missing injuries in the autopsy reports and C3 (partial discordance in favor of the necroptic diagnosis- missing injuries in the medical files. Data were analyzed with SPSS version 20.0. Results: We analyzed 194 cases of death due to head injuries. We found a total concordance between the clinical death diagnosis and autopsy diagnosis in 30.4% of cases and at least one discrepancy in 69.6% of cases. Increasing the duration of hospitalization directly correlates with the amount of the imaging investigations and these in turn correlates with an increased rate of diagnosis concordance. Among the patients with stage 3 coma who associated a spinal cord injury, we found a partial diagnosis discordance in 50% of cases and a total discordance in 50% of cases, possibly due to the need for conducting emergency imaging investigation and the need for surgical treatment. In cases with partial and total discordant diagnosis, at least one lesion was omitted in 45.1% of the cases. The most commonly omitted injuries in C2 cases were subdural hematoma, intracerebral

  18. [Psychiatric autopsy: its uses and limits in France].

    Science.gov (United States)

    Abondo, M; Masson, M; Le Gueut, M; Millet, B

    2008-09-01

    Within the framework of an evaluation program for the prevention of suicide in Brittany conducted by the academic department of psychiatry (University of Rennes, Brittany, France), we have addressed the issue of the potential usefulness of psychological autopsy as a tool for the better comprehension of suicide risk factors. We reviewed the appropriate literature in 30 articles found amongst those obtained from the "Medline" database. These articles were selected according to the quality of their methodology. For the Medline data retrieval search, the following keywords were used: "psychological autopsy", "psychiatric autopsy", "psychological autopsy and methodology", "psychiatric autopsy and methodology". This review's objective was to determine, firstly the nature and the content of psychological autopsies, secondly to evaluate their use as a methodological tool to assist the comprehension and prevention of suicide. Finally, it was also to assess its feasibility for use in France. The majority of the published studies using psychological autopsy for the evaluation of suicide expertise came from Scandinavian or Anglo-Saxon countries. Schneidman [Schneidman ES. The psychological autopsy. Suicide Life Threat Behav 1981;11:325-40], whose aim was to clarify the causes of sudden death related to psychological circumstances, focused on suicidal intentions and the symptoms exhibited. He coined the term: "psychological autopsy". Gradually, the definition of psychological autopsy has evolved and is now being used for the evaluation of death by suicide with a single goal in mind: to retrospectively identify any suicidal predictive and risk factors available at the time of the event. At present, no unequivocal definition of "psychological autopsy" has been put forth. However, this formerly only descriptive procedure is now becoming more analytical in nature (comparison of psychiatric profiles between pre- and postmortem assessments, research on precipitating factors

  19. Cadmium Concentration in Human Autopsy Tissues.

    Science.gov (United States)

    Lech, Teresa; Sadlik, Józefa K

    2017-10-01

    The concentration of cadmium in human tissues obtained on the basis of autopsies of non-poisoned Polish people (n = 150), aged from 1 to 80 years, examined between 1990 and 2010, is presented. The following values were found in wet digested samples by flame atomic absorption spectrometry (FAAS) (mean ± SD, median, and range, μg/g of wet weight): brain 0.020 ± 0.031, 0.084, 0-0.120 (n = 41); stomach 0.148 ± 0.195, 0.084, 0-1.25 (n = 89); small intestine 0.227 ± 0.231, 0.130, 0-0.830 (n = 39); liver 1.54 ± 1.55, 1.01, 0.015-9.65 (n = 99); kidney 16.0 ± 13.2, 14.0, 0.62-61.3 (n = 91); lung 0.304 ± 0.414, 0.130, 0-1.90 (n = 25); and heart 0.137 ± 0.107, 0.140, 0.017-0.250 (n = 4). Additionally, results (n = 13 people, aged from 2 to 83 years, 63 samples) obtained by inductively coupled plasma optical emission spectrometry (ICP OES) between 2010 and 2015 are given. The obtained data on Cd concentration in the human body can be used to estimate the amounts occurring in "healthy" people and those occurring in cases of chronic or acute poisonings with Cd compounds, which are examined for forensic purposes or to assess environmental exposure levels.

  20. Unusual autopsy finding: Simon’s bleeding

    Directory of Open Access Journals (Sweden)

    Bülent Eren

    2013-10-01

    Full Text Available Objective: To determine whether or not hanging had taken place before or after the death of the victim is quite important in the identification of criminal cases pretended to be suicidal attempts. Material and Methods:Evidence for Simon’s bleeding was searched in cases included in the study group after retracting soft tissue and organs away from the field of interest for full exposure of the region of lumbar spinal veretebrae without macroscopic grading of the severity of bleeding, and determining the lumbar level of bleeding. The cases autopsied in Bursa Morgue Department between 2009 and 2011 were retrospectively investigated and evaluated.Results: A total of 848 cases (664 males, and 184 females, male/female ratio, 3.6 : 1 were included in the study. A total of 270 (31.8 % cases had Simon’s bleeding. A significant difference in the frequency of Simon’s bleeding exists among various causes of death. A 28.5 % (n = 77 of the cases with Simon’s bleeding were in the group with hanged death cases (p < 0.001. Conclusion:Splinter bleedings identified originally by Simon on the ventral, and later dorsal aspects of the spinal disci in cases of hanging were also observed later in deaths not related to hanging, however it was concluded that these types of bleeding could not be detected in cases of postmortem hanging. When we evaluated all groups, the results we obtained do not support the assertion that the incidence of Simon’s bleeding decreases with aging. Instead, when compared with all other groups, the incidenceof Simon’s bleeding was also higher in cases of hanging with the highest mean age.

  1. Sudden death victims forensic physician and autopsy results.

    Science.gov (United States)

    Ceelen, Manon; van der Werf, Christian; Hendrix, Anneke; Naujocks, Tatjana; Woonink, Frits; de Vries, Philip; van der Wal, Allard; Das, Kees

    2015-08-01

    The goal of this study was to ascertain accordance between cause of death established by the forensic physician and autopsy results in young sudden death victims in the Netherlands. Sudden death victims aged 1-45 years examined by forensic physicians operating in the participating regions which also underwent an autopsy between January 2006 and December 2011 were included (n = 70). Cause of death established by the forensic physician based on the external medicolegal examination was compared with autopsy findings using the ICD10-classification. Autopsy findings revealed that the majority of sudden death victims have died from a cardiac disease (n = 51, 73%). Most of the presumed heart disease related cases were confirmed by autopsy (n = 13, 87%). On the contrary, a large number of deaths caused by circulatory diseases were not recognised by the forensic physician (n = 38, 75%). In most of these cases, the forensic physician was forced to report an undetermined cause due to the lack of a solid explanation for death. Cause of death reported by the forensic physician appeared to be in agreement with the autopsy results in 12 cases (17%). Cause of death determination in young sudden death victims is a difficult task for forensic physicians due to the limited tools available during the medicolegal examination. An effort should be made to standardize extensive post-mortem investigation after sudden death in the young. Autopsy can provide valuable information regarding the cause of death, which is of great importance in view of the identification of inheritable diseases among decedents and their families. Copyright © 2015 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  2. Review of Handbook of Autopsy Practice, Brenda L. Waters (Ed.). 4th edition, Humana Press (2009). ISBN: 978-1-58829-841-6

    DEFF Research Database (Denmark)

    Leth, Peter Mygind

    2010-01-01

    . In the same period the autopsy rate in teaching hospitals has declined. A comprehensive and updated version is therefore most welcome. Part I have six completely new chapters, and contain an assortment of tools of great practical value for the forensic pathologist. There is for example a next-of-kin letter...... techniques used for post-mortem investigation of the cardio-vascular system, the nervous system and eye and adnexa. Autopsy microbiology, chemistry and chromosome analysis and autopsies of bodies containing radioactive material are also among the topics that are addressed in this handbook, as well as post......-mortem imaging techniques. Part II begins with a list of special histologic stains, but the bulk is devoted to an alphabetic listing of major diseases with possible or expected findings and recommended procedures. This part has also been updated with new diseases and recent references. Part III provides a series...

  3. Aerosol Generation During Bone-Sawing Procedures in Veterinary Autopsies.

    Science.gov (United States)

    Wenner, L; Pauli, U; Summermatter, K; Gantenbein, H; Vidondo, B; Posthaus, H

    2017-05-01

    Bone-sawing procedures are routinely performed during veterinary and human autopsies and represent an important source for infectious aerosols. Here we investigate the generation of aerosols during bone-sawing procedures using 5 different saws regularly used in veterinary and human pathology. In particular, the electrical bone band saw produced vast amounts of aerosolized particles less than 5 µm in diameter, which spread rapidly throughout the entire autopsy hall, leading to an exposure of all personnel. Other sawing devices tested were a diamond-coated cut grinder, an oscillating saw, a reciprocating saw, and a hand bone saw. Although these saws, especially the handsaw, generated fewer aerosolized particles than the band saw, the level of exposure of the saw operator would still be of concern in cases where infectious material would require sawing. Contamination of the entire autopsy area was successfully prevented by the construction of a separately ventilated sawing cabin inside the existing autopsy room. Saw operators in this cabin, however, were exposed to even higher aerosol concentrations. Protection of saw operators was achieved by using a powered air-purifying respirator. In conclusion, our results demonstrate that all bone-sawing procedures applied in veterinary and human pathology can generate aerosols that are of concern for the health of autopsy personnel. To reduce the risk of aerosol infections from bone-sawing procedures, efficient and properly designed ventilation systems to limit the spread of aerosols and appropriate personal protective equipment against aerosols for exposed personnel should be implemented.

  4. [Role of forensic autopsy in deaths caused by medical practice].

    Science.gov (United States)

    Funayama, Masato

    2013-03-01

    Autopsies are required to determine the cause of deaths due to medical practice. In Japan, some deaths resulting from medical practice are treated as criminal cases. In such instances, medicolegal autopsies ordered by the police or public prosecutors are performed. One problem with a medicolegal autopsy, however, is that judicial institutes often refuse to disclose coroners' reports. As a result, parties with an interest in the findings (the bereaved or medical institutions) are unable to receive detailed autopsy information for a long period of time. When an autopsy is performed by a medical examiner who is a government official, the rules governing the disclosure of the coroner's report may not be as strict, at least for the bereaved, although such a system is in place in only four regions of Japan. In April 2013, a new law pertaining to the cause of death will come into effect. However, it does not include new articles relating to deaths caused by medical practice, meaning that such deaths will continue to be investigated under existing regulations in the present law, which includes the Medical Practitioners' Act. The government plans to draft another law covering deaths related to medical practice, and it is hoped that clinical medical societies, including the Japan Surgical Society, will appeal to the government to solve problems related to the determination of the cause of deaths related to medical practice.

  5. Carolina Sandhills NWR Flora and Fauna

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This list was complied by members of the South Carolina Association of Naturalists on October 28, 2007 at Carolina Sandhills National Wildlife Refuge. The list...

  6. Libraries in South Carolina: MedlinePlus

    Science.gov (United States)

    ... this page: https://medlineplus.gov/libraries/southcarolina.html Libraries in South Carolina To use the sharing features ... Columbia University of South Carolina School of Medicine Library 6311 Garners Ferry Road Columbia, SC 29208 803- ...

  7. Meckel-Gruber Syndrome: Autopsy Based Approach to Diagnosis

    Directory of Open Access Journals (Sweden)

    Asaranti Kar

    2016-01-01

    Full Text Available Meckel-Gruber syndrome (MGS is a rare lethal congenital malformation affecting 1 in 13,250-140,000 live births. The classical diagnostic triad comprises multicystic dysplastic kidneys, occipital encephalocele, and postaxial polydactyly. It can variably be associated with other malformations such as cleft lip and palate, pulmonary hypoplasia, hepatic fibrosis, and anomalies of central nervous system. A 20 weeks fetus was diagnosed as MGS with classical features along with many other congenital abnormalities such as microcephaly, microphthalmia, hypertelorism, cleft lip and palate, neonatal teeth, and the right side club foot which were detected only after doing autopsy. This case is reported because of its rarity emphasizing the importance of neonatal autopsy in every case of fetal death, especially where the antenatal diagnosis has not been made previously. A systematic approach to accurate diagnosis of MGS based on autopsy will be described here which can allow recurrence risk counseling and proper management in future pregnancies.

  8. [Arrhythomgenic right ventricular dysplasia and sudden death: An autopsy and histological study].

    Science.gov (United States)

    Haj Salem, N; Mesrati, M A; Hadhri, R; Besbes, S; Belhadj, M; Aissaoui, A; Zakhama, A; Chadly, A

    2015-09-01

    Arrhythmogenic right ventricular dysplasia (ARVD) is cardiomyopathy where normal myocardial tissue is replaced with fibrofatty tissue. Histological examination performed on myocardial biopsy or on autopsy samples are used to confirm the diagnosis. However, in many cases, the diagnosis cannot be made on a simple macroscopic and histological study and requires genetic analysis and molecular biology. In this work, we propose to describe the main macroscopic and histological findings of ARVD through the study of an autopsy series. We report 12 autopsy cases of sudden death in ARVD collected in the Department of Forensic Medicine of the University Hospital Fattouma Bourguiba Monastir (Tunisia) during a period of 20years. Microscopic examination was performed on 5microns thick histological sections. All slides were reviewed by two operators in a double blind (physician pathologist, pathologist) and in each, the percentage of adipose tissue, fibrosis and infarction in the right ventricle, left ventricle and interventricular septum, the presence or absence of inflammatory infiltrate, the presence or absence of signs of degeneration of myocytes were noticed. ARVD was found in 12 cases (1.8% of sudden cardiac death). The age ranged between 13 and 67years (mean age: 45.3years). The death occurred in half of the cases during exercise. Macroscopic examination of the RV showed the presence of a wall thinning (thickness<3mm) in 9 cases. Histological study highlight RV adipose infiltration in all cases with a percentage between 15% and 60%, fibrotic lesions were observed in only 9 cases with an average percentage of 10.25% and signs of degeneration of myocytes were noted in 10 cases. In concordance with what has been reported in the literature, there is still no consensus regarding the criteria to be adopted to pose with certainty the diagnosis of ARVD and the presence of adipose tissue remains the criterion more suggestive. Copyright © 2015. Published by Elsevier SAS.

  9. HISTOPATHOLOGICAL PATTERNS OF LIVER DISEASES IN MEDICAL AUTOPSIES

    Directory of Open Access Journals (Sweden)

    Sampa Choudhury

    2017-04-01

    Full Text Available BACKGROUND Liver is the site for wide spectrum of diseases, primary as well secondary, which maybe symptomatic or silent and incidentally diagnosed during routine investigation or autopsy examination. The main purpose of our study was to identify different spectrum of histopathological findings of liver in medical autopsies. MATERIALS AND METHODS The study was conducted in the Department of Pathology, Regional Institute of Medical Sciences (RIMS, Imphal. All the consecutive liver specimens dissected out during medical autopsy and postmortem were included in the study. Detailed clinical information including age and sex were obtained. All the liver specimens were examined meticulously and the gross findings were noted down. Histopathological slides were prepared from the representative areas and findings recorded. RESULTS In the present study, a total of 330 liver specimens were examined from medical autopsies during the period of 5 years. Among them, 39 cases were autolysed and remaining 291 cases were analysed grossly and histologically. 249 (85.5% cases were males and 42 (14.4% cases were females. 71 (24.39% cases had no obvious pathology, followed by fatty liver (20.96%, portal triaditis (18.55%, cirrhosis (14.08%, hepatitis (11.34% and steatohepatitis (5.15%. Other important cases like liver necrosis (2.40%, granulomatous lesion (0.68%, tuberculosis (0.68%, chronic venous congestion (0.68%, malaria pigment (0.34%, leukaemic infiltration (0.34% and bile duct hamartoma (0.34%. Fatty liver and cirrhosis was found to be most common in the age group of 41-50 years with male predominance. Incidentally, diagnosed liver diseases are not uncommon in medical autopsy. CONCLUSION We concluded that the autopsy examination of liver is very helpful to identify silent liver diseases as it is very common in apparently healthy individuals.This data may be utilised for a medical audit.

  10. [Autopsies for anatomical teaching and training in clinical forensic medicine].

    Science.gov (United States)

    Hammer, U; Blaas, V; Büttner, A; Philipp, M

    2015-12-01

    Clinical forensic medicine does not only entail examination of patients after physical violence but also the option of clinical autopsies, e.g. after non-notifiable complications of medical interventions, after fatalities closely following medical interventions or fatalities as a result of injuries when the public prosecutor decides not to order a medicolegal autopsy. Based on this routine the Institute of Forensic Medicine at the University of Rostock offers a training course in topographical anatomy to physicians for further training in interventional and surgical disciplines. At the beginning of autopsies the participants can explore the approaches of interventional puncture techniques as well as surgical techniques and the basic topographical anatomy in small groups of 2-4 persons under the supervision of forensic examiners. The format is essentially oriented to the early further training period but fulfils the requirements for the exploration of complex operative techniques. The course was adapted for physicians and offered separately to students. The explorations are performed manually or by support with autopsy instruments. The courses offer an ideal room for individual, discipline-specific topics and result in a great benefit for all participants. A statistical assessment can only be achieved with a larger number of participants. Making autopsy rooms available for teaching and further training represents an additional feature to the profile of clinical forensic medicine. Lessons in topographical anatomy provide a great benefit for patient safety. It seems to be important to offer the opportunity to address individual interests in a closed meeting to consolidate skills and abilities in a non-judgemental environment. The post-mortem examiners have to ensure that the autopsy is carried out lege artis. Basic ethical principles and all regulations from an accredited scope have to be adhered to.

  11. Clinical diagnosis versus autopsy findings in polytrauma fatalities

    Directory of Open Access Journals (Sweden)

    Fakler Johannes K

    2010-10-01

    Full Text Available Abstract Objectives The aim of the study was to determine if differences in clinical diagnosis versus autopsy findings concerning the cause of death in polytrauma fatalities would be detected in 19 cases of fatal polytrauma from a Level 1 trauma centre. Methods Clinical diagnoses determining the cause of death in 19 cases of fatal polytrauma (2007 - 2008 from a Level 1 trauma centre were correlated with autopsy findings. Results In 13 cases (68%, the clinical cause of death and the cause of death as determined by autopsy were congruent. Marginal differences occurred in three (16% patients while obvious differences in interpreting the cause of death were found in another three (16% cases. Five fatalities (three with obvious differences and two with marginal differences were remarked as early death (1-4 h after trauma and one fatality with marginal differences as late death (>1 week after trauma. Obvious and marginal discrepancies mostly occurred in the early phase of treatment, especially when severely injured patients were admitted to the emergency room undergoing continued cardiopulmonary resuscitation, i. e. limiting diagnostic procedures, and thus the clinical cause of death was essentially determined by basic emergency diagnostics. Conclusions Autopsy as golden standard to define the cause of death in fatal polytrauma varies from the clinical point of view, depending on the patient's pre-existing condition, mechanism of polytrauma, necessity of traumatic cardiopulmonary resuscitation, survival time, and thus the possibility to perform emergency diagnostics. An autopsy should be performed at least in cases of early fatal polytrauma to help establishing the definite cause of death. Moreover, autopsy data should be included in trauma registries as a quality assessment tool.

  12. High autopsy rates at a university medical center. What has gone right?

    Science.gov (United States)

    Haque, A K; Patterson, R C; Grafe, M R

    1996-08-01

    Identification of factors that contribute to a high autopsy rate at our institution. An objective analysis of the Autopsy Service's organization, functions, and process flow to identify factors that impact the autopsy rate. The University of Texas Medical Branch at Galveston, Tex. Statistics were collected using the autopsy log book and computerized data bank. The events starting at the time of a patient's death through the completion of the autopsy report were reviewed. The role of each significant event was analyzed. The annual autopsy rates between 1981 and 1995 ranged between 45% and 59%. The largest number of nonmedicolegal autopsies were received from the Department of Internal Medicine. The Texas Department of Criminal Justice Hospital contributed the largest number of medicolegal autopsies. We conclude that the following key factors contribute to our high autopsy rates: (1) the organization and multiple functions of the Autopsy Service, particularly the presence of a Decedent Affairs Office, dedicated resident assignments, and internal and external quality control of the autopsies; (2) close interactions with clinicians, including timely communication of autopsy results to clinicians and a fostering of positive attitude among clinical residents and faculty; and (3) other factors such as the contributions to hospital risk management, disproving the idea that there may be increased litigation related to high autopsy rates, and support by the hospital administration.

  13. South Carolina State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-08-01

    The South Carolina State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in South Carolina. The profile is the result of a survey of NRC licensees in South Carolina. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as definied by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in South Carolina.

  14. North Carolina State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-08-01

    The North Carolina State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in North Carolina. The profile is the result of a survey of NRC licensees in North Carolina. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in North Carolina.

  15. Extraskeletal Osteosarcoma of the Thigh: An Autopsy Case Report

    Directory of Open Access Journals (Sweden)

    Akihito Nagano

    2009-01-01

    Full Text Available We report a case of extraskeletal osteosarcoma (ESOS and autopsy findings. A 35-year-old man presented with an ossified tumor in the right thigh and lung metastasis. The lung tumors continued to develop despite multiagent chemotherapy and caused death within 8 months. Autopsy revealed many secondary lesions in the lungs, especially in the left lung. Histopathologically, the primary tumor and one of the secondary tumors showed proliferation of spindle-shaped tumor cells focally forming lace-like osteoid material. Therefore, we made a definite diagnosis of ESOS.

  16. [Autopsy room and the July 30th 2004 memorandum].

    Science.gov (United States)

    Canas, Frédéric; Guillou, Pierre-José; Lorin de la Grandmaison, Geoffroy; Diebold, Marie-Danièle; Patey, Martine; Bureau-Chalot, Florence; Bajolet, Odile; Jeunehomme, Gérard; Bernard, Mary-Hélène; Durigon, Michel; Pluot, Michel

    2005-06-01

    With the July 30th 2004 memorandum, for the first time a text is specifically dedicated to the architecture of the autopsy room. This memorandum reaffirms certain technical specifications stated in the May 7th 2001 decree applicable to hospital mortuaries. It supplements or modifies certain elements, particularly liquid waste processing, which will require new arrangements in death chambers and new expenditures for hospital administrations. It includes the principle of precaution and requires a new approach to handling human corpses in the autopsy room.

  17. Usefulness of postmortem computed tomography before forensic autopsy for alerting forensic personnel to tuberculosis infection.

    Science.gov (United States)

    Usui, Akihito; Kawasumi, Yusuke; Hosokai, Yoshiyuki; Hayashizaki, Yoshie; Funayama, Masato; Saito, Haruo

    2012-08-01

    Since May 2009, we have performed multislice computed tomography (MSCT) prior to forensic autopsy for cases of suspicious death. In the present case, innumerable widely scattered nodules in both pulmonary fields on MSCT were indicative of miliary tuberculosis (TB). At autopsy, both lungs were submerged in formalin fluid immediately after removal from the body. Miliary TB was finally diagnosed based on microscopic findings. TB is a disease that autopsy room workers need to be aware of to protect themselves. Unfortunately, because little medical information about deceased individuals is usually available before forensic autopsy, the diagnosis of TB is frequently not made until autopsy. This leads to a much higher incidence of TB in autopsy room staff members even if they wear protective clothing. Therefore, MSCT before forensic autopsy may identify suspected cases of miliary TB in advance and thus help to prevent TB infection in forensic autopsy personnel.

  18. Relatives' attitudes towards medico-legal investigation and forensic autopsy: a study from South Delhi.

    Science.gov (United States)

    Behera, C; Rautji, R; Dogra, T D

    2008-04-01

    Relatives of deceased persons on whose bodies a medico-legal autopsy had been performed at the All India Institute of Medical Sciences, New Delhi, India were personally asked to complete a questionnaire. The aim of study was to determine surviving family members' attitudes towards medico-legal investigation and forensic autopsy. The majority of the relatives showed a positive attitude towards forensic autopsy but were not aware of the detailed procedure of the autopsy. They wanted sufficient information to be provided before the autopsy. They showed a great interest in autopsy results i.e. the cause of death. It was concluded that sufficient relevant explanations given before the autopsy improves the relatives' acceptance and helps alleviate the suffering of the bereaved. The experience and opinions of relatives may help an autopsy surgeon in more effective management of medico-legal cases.

  19. How the pediatric autopsy yields valuable information in a vertically integrated health care system

    National Research Council Canada - National Science Library

    Newton, David; Coffin, Cheryl M; Clark, Edward B; Lowichik, Amy

    2004-01-01

    Although autopsy rates have declined significantly in recent decades, studies continue to validate the autopsy as an important source of clinically relevant information, a teaching tool, and a quality assurance measure...

  20. Virtual autopsy in forensic sciences and its applications in the forensic odontology

    OpenAIRE

    Franco do Rosário Junior, Ademir; Henrique Couto Souza, Paulo; Coudyzer, Walter; Thevissen, Patrick; Willems, Guy; Jacobs, Reinhilde

    2012-01-01

    Nowadays, technological advances are becoming more and more important in forensic sciences. Yet autopsy is still one of the very traditional methods. This also applies for dental autopsies, in which visual, photographic and radiological evidences are collected. In this context, Virtual Autopsy appears as a helpful and complementary tool for dental and medical cadaveric examination. Using high-tech radiological approaches, Virtual Autopsy may provide, through images, an efficient and more accu...

  1. Virtopsy versus autopsy in unusual case of asphyxia: case report.

    Science.gov (United States)

    Aquila, I; Falcone, C; Di Nunzio, C; Tamburrini, O; Boca, S; Ricci, P

    2013-06-10

    We report the case of a 70-year-old woman found dead in her apartment in the South of Italy in February 2011. The detailed data showed that the victim was affected by familiar-type paranoid schizophrenia. This finding was confirmed by the discovery of antipsychotic and tricyclic antidepressant drugs in the house and the deposition of her psychiatric therapist. Before the autopsy, a multislice computed tomography (MSCT) scanning of the thoracic and facial maxillo-cervical area was performed that has allowed anatomical identification and diagnosis of a mechanical obstruction as the cause of death. The autopsy has showed the presence of materials obstructing the trachea totally. Histological and toxicological investigations were carried out on the victim. The toxicological investigation has shown the presence of metabolites of tricyclic antidepressants and antipsychotics in the blood and urine. The histology showed the presence of foreign-origin materials (starch fibres) inside the pulmonary alveolus. The cause of death was asphyxia due to obstruction by food-origin material. In this case the radiological data have been compared with the autopsy and toxicological and histological data. The comparison of results has shown that MSCT scanning may aid in identification of occlusion and then in determination of the cause of death. In conclusion, MSCT scanning can be proposed in the cases of suspected asphyxia, as the screening procedure of first instance to produce preliminary information useful to rapidly develop the successive autopsy performance. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  2. A Histological Autopsy Study of the Thyroid gland in Human ...

    African Journals Online (AJOL)

    SITWALA COMPUTERS

    1Department of Pathology and Microbiology, University Teaching Hospital, Lusaka, Zambia. 2Department of Pathology and Microbiology, School of Medicine, University of Zambia, Lusaka, Zambia. Key Words: Thyroid histology, HIV infection, Autopsy, Adult. ABSTRACT. Background: Despite the high prevalence of Human.

  3. Autopsied case of tuberculous meningitis showing interesting CT findings

    Energy Technology Data Exchange (ETDEWEB)

    Abiko, Takashi; Higuchi, Hiroshi; Imada, Ryuichi; Nagai, Kenichi (Iwate Prefectural Central Hospital (Japan))

    1983-11-01

    A 61-year-old female patient died of a neurological disorder of unknown origin one month after the first visit and was found to have had tuberculous meningitis at autopsy. CT revealed a low density area showing an enlargement of the cerebral ventricle but did not reveal contrast enhancement in the basal cistern peculiar to tuberculous meningitis.

  4. Bereaved mothers' attitudes regarding autopsy of their stillborn baby

    African Journals Online (AJOL)

    and Human Development, and the National Institute on Deafness and Other. Communication Disorders: U01 HD055154, U01 HD045935, U01 HD055155,. U01 HD045991, and U01 AA016501. Conflicts of interest. None. 1. Holste C, Pilo C, Pettersson K, et al. Mothers' attitudes towards perinatal autopsy after stillbirth. Acta.

  5. Review Article: Autopsy and the religious beliefs of Christains ...

    African Journals Online (AJOL)

    Even though the advantages of autopsy were acknowledged by Christians, Muslims and Jews, it is still not completely accepted by these religions due to some ethical questions raised by their religious beliefs. A good look at the literatures has shown that, none of these three religions absolutely prohibited the performance ...

  6. Invasive pulmonary aspergillosis: A study of 39 cases at autopsy

    Directory of Open Access Journals (Sweden)

    Vaideeswar P

    2004-01-01

    Full Text Available Background: Aspergillus is a common cause of invasive mycosis, especially in immunocompromised or immunosuppressed individuals. Aims: To study the incidence of invasive pulmonary aspergillosis and evaluate the predisposing factors and clinico-pathological manifestations. Settings and Design: Retrospective analysis of autopsy material from a tertiary care hospital. Material and Methods: All autopsies performed over a 12-year period were reviewed and cases with invasive aspergillosis were analysed with respect to their clinical presentation, predisposing factors, gross and histological features, complications and causes of death. Results: Among a total of 20475 autopsies performed in 12 years, 39 patients (0.19 % had invasive pulmonary aspergillosis. There were 28 males and 11 females. Their ages ranged from five months to 67 years. Dyspnoea, fever, cough with mucopurulent expectoration, chest pain and haemoptysis were commonly encountered symptoms. Forty-one per cent of the patients had no respiratory symptoms. Fungal aetiology was not entertained clinically in any of the patients. The major underlying conditions were prolonged antibiotic therapy, steroid therapy, and renal transplantation, often associated with underlying lung diseases. Pneumonia, abscesses, vascular thrombosis and infarction were common findings at autopsy. Antecedent tuberculosis, mucormycosis, Pneumocystis carinii pneumonia and Cytomegalovirus infection were also present. In most cases, death was related to extensive pulmonary involvement or fungal dissemination. Conclusion: A diagnosis of invasive pulmonary aspergillosis should always be borne in mind whenever one is dealing with recalcitrant lung infections even with subtle immunosuppression. Radiological investigations and serologic markers can be utilised for confirmation and prompt therapy.

  7. Verbal autopsy in establishing cause of perinatal death | Iriya | East ...

    African Journals Online (AJOL)

    Introduction: Perinatal mortality is a sensitive indicator of health status of a community and is also highly amenable to intervention. The causes of perinatal deaths in developing countries are often difficult to establish. Verbal autopsy has been used in several countries for children and adults, but seldom for perinatal cause.

  8. The Significance of Subendocardial Hemorrhages Detected in Forensic Autopsies

    National Research Council Canada - National Science Library

    Nursel Türkmen İnanır; Selçuk Çetin; Filiz Eren; Bülent Eren

    2015-01-01

    ... (if any), and whether it can be evaluated as a vital finding.Material and Method :285 autopsy cases diagnosed as SEH which were brought to the Group Presidency of Morgue Specialization Department of the State Institute of Forensic Medicine of Bursa...

  9. From gunstore to smoking gun: tracking guns that kill children in North Carolina.

    Science.gov (United States)

    Campbell, Brendan T; Radisch, Deborah L; Phillips, J Duncan; von Allmen, Daniel

    2004-12-01

    This study reviews the epidemiology of pediatric firearm deaths in North Carolina and estimates the time from the retail sale of guns to their involvement in pediatric firearm deaths. The authors reviewed autopsy reports for all children 0 to 14 years of age that died of firearm-related injuries in North Carolina from January 1999 through December 2002. Data obtained included demographic information, firearm type, and manner of death. Data from the Bureau of Alcohol, Tobacco and Firearms, which traced guns involved in crimes and determined the time elapsed from purchase to their involvement in a crime (ie, time-to-crime were also reviewed). During the study period, 40 children died of firearm injuries. Mean age was 7.6 years. Handguns were responsible for the majority of deaths (59%) followed by shotguns (27%), rifles (10%), and undetermined cause (10%). Most deaths were homicides (67%) followed by unintentional death (18%), suicide (13%), and undetermined cause (2%). Most crime guns (76%) were purchased legally, and many (40%) had a time-to-crime of less than 3 years. Legally purchased firearms pose a significant threat to children in North Carolina. A more restrictive approach to the sale of handguns is a logical approach to reducing pediatric firearm-related deaths in the United States.

  10. Effects on the estimated cause-specific mortality fraction of providing physician reviewers with different formats of verbal autopsy data

    Directory of Open Access Journals (Sweden)

    Chow Clara

    2011-08-01

    Full Text Available Abstract Background The process of data collection and the methods used to assign the cause of death vary significantly among different verbal autopsy protocols, but there are few data to describe the consequences of the choices made. The aim of this study was to objectively define the impact of the format of data presented to physician reviewers on the cause-specific mortality fractions defined by a verbal autopsy-based mortality-surveillance system. Methods Verbal autopsies were done by primary health care workers for all deaths between October 2006 and September 2007 in a community in rural Andhra Pradesh, India (total population about 180,162. Each questionnaire had a structured section, composed of a series of check boxes, and a free-text section, in which a narrative description of the events leading to death was recorded. For each death, a physician coder was presented first with one section and then the other in random order with a 20- to 40-day interval between. A cause of death was recorded for each data format at the level of ICD 10 chapter headings or else the death was documented as unclassified. After another 20- to 40-day interval, both the structured and free-text sections of the questionnaire were presented together and an index cause of death was assigned. Results In all, 1,407 verbal autopsies were available for analysis, representing 94% of all deaths recorded in the population that year. An index cause of death was assigned using the combined data for 1,190 with the other 217 remaining unclassified. The observed cause-specific mortality fractions were the same regardless of whether the structured, free-text or combined data sources were used. At the individual level, the assignments made using the structured format matched the index in 1,012 (72% of cases with a kappa statistic of 0.66. For the free-text format, the corresponding figures were 989 (70% and 0.64. Conclusions The format of the verbal autopsy data used to assign

  11. [A Forensic Autopsy Case Applied for Asbestos-Related Disease].

    Science.gov (United States)

    Makihara, Kosuke; Hamada, Tetsuo; Kasai, Kentaro; Tanaka, Toshiko; Sato, Hiroaki

    2016-03-01

    We had a forensic autopsy case that required additive pathological examination for the asbestos-related lung disease compensatory application afterwards. A man in his sixties with a history of occupational asbestos inhalation who had neither visited a hospital nor received a physical examination received forensic autopsy because of his death from unknown cause. An inmate said, "He developed cough and dyspnea, and died in the progression of the symptoms." The autopsy revealed widespread pleural plaques on both sides of the parietal pleura and multiple tumors in both sides of the lungs. The cause of death was diagnosed as lung cancer. Additional pathological examination was asked by his family to certify that he had suffered from asbestos-related lung disease in order to apply to the Asbestos-related Damage Relief Law. The Japanese criteria of the compensation law of asbestos-related lung cancer is the detection of more than 5,000 asbestos bodies per gram of dry lung tissue, while his number of asbestos bodies was 4,860. Asbestos bodies were reported to be accumulated in the distal lung parenchyma with no pathological changes. The present lung samples were collected from proximal section around the tumor, which might have made the number of asbestos bodies less than the criteria. Both the number of patients suffering from asbestos-related lung disease and the number of forensic autopsy cases have increased in Japan. Collecting lung samples from the appropriate lung section is essential and should be noted when the lung cancer is suspected at forensic autopsy in order to apply for asbestos-related lung disease compensation.

  12. An osteological revisitation of autopsies: comparing anthropological findings on exhumed skeletons to their respective autopsy reports in seven cases.

    Science.gov (United States)

    Cappella, A; Castoldi, E; Sforza, C; Cattaneo, C

    2014-11-01

    Forensic anthropologists and pathologists are more and more requested to answer questions on bone trauma. However limitations still exist concerning the proper interpretation of bone fractures and bone lesions in general. Access to known skeletal populations which derive from cadavers (victims of violent deaths) who underwent autopsy and whose autopsy reports are available are obvious sources of information on what happens to bone trauma when subjected to taphonomic variables, such as burial, decomposition, postmortem chemical and mechanical insults; such skeletal collections are still however quite rare. This study presents the results of the comparative analysis between the autopsy findings on seven cadavers (six of which victims of blunt, sharp or gunshot wounds) and those of the anthropological assessment performed 20 years later on the exhumed dry bones (part of the Milano skeletal collection). The investigation allowed us to verify how perimortem sharp, blunt and gunshot lesions appear after a long inhumation period, whether they are still recognizable, and how many lesions are no longer detectable or were not detectable at all compared to the autopsy report. It also underlines the importance of creating skeletal collections with known information on cause of death and trauma. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  13. Tree-Ring Dating Of Old-Growth Longleaf Pine (Pinus palustris Mill.) Logs From An Exposed Timber Crib Dam, Hope Mills, North Carolina, U.S.A

    National Research Council Canada - National Science Library

    Saskia L. Van De Gevel; Justin L. Hart; Henri D. Grissino-Mayer; Kenneth W. Robinson

    2009-01-01

    Abstract On 26 May 2003, intense rainfall from a series of thunderstorms in eastern North Carolina caused flooding that eventually destroyed the concrete dam in Hope Mills, draining Hope Mills Lake...

  14. Distance Education and Plagiarism Prevention at the University of South Carolina Upstate

    Science.gov (United States)

    Kirsch, Breanne A.; Bradley, Lola

    2012-01-01

    At the University of South Carolina Upstate, two librarians created a series of workshops to proactively prevent plagiarism. To reach distance education students, online workshops were developed in Blackboard including basic and advanced workshops for lower and upper-level courses. The workshops are intended to introduce students to the concepts…

  15. An autopsy case of asthmatic death: Usefulness of biochemical examination

    Directory of Open Access Journals (Sweden)

    Kinoshita Hiroshi

    2008-01-01

    Full Text Available Background. Asthma is the one of the major causes of sudden death in Japan. Postmortem diagnosis of asthma has been based on morphological findings in lungs, but it histological evidence, was also reported that the biochemical markers such as total and specific immunoglobulin E (IgE are useful. Case report. We present here a case of fatal asthmatic death. A Japanese male in his thirties, complaining of dyspnea, collapsed suddenly. He was taken by ambulance to hospital, but cardiopulmonary resuscitation was ineffective. From autopsy findings, we concluded that the cause of death was asphyxia due to asthma attack. Biochemical findings indicated that the deceased had a severe asthmatic condition. Conclusion. In the presented case, the biochemical examination of the serum obtained at autopsy gave helpful information for the diagnosis that asthmatic attack was a cause of death.

  16. The Homicide-Suicide Phenomenon: Findings of Psychological Autopsies.

    Science.gov (United States)

    Knoll, James L; Hatters-Friedman, Susan

    2015-09-01

    Homicide-suicide represents a single episode of violence which may decimate an entire family. This study aimed to further describe motives and context of these tragedies. Psychological autopsies were completed for 18 homicide-suicide cases in Dallas, Texas. This included postevent interviews with surviving family members and review of police and coroner records. Two-thirds of perpetrators had made either verbal or written threats prior to the homicide-suicide. A simplified typology describing victim-perpetrator relationship and motive type is suggested for future studies and clinical ease. Two-thirds of perpetrators fell into the category of Intimate-Possessive, most of whom were depressed men who were abusing substances and undergoing separation. Additional categories included Intimate-Ailing, Filial-Revenge, Familial-Psychotic, and Friend-Psychotic. Further, implications from this psychological autopsy study regarding risk assessment include use of collateral interviews regarding threats and past violence. © 2015 American Academy of Forensic Sciences.

  17. [Value of bacteriologic studies within the scope of forensic autopsies].

    Science.gov (United States)

    Schneider, V

    1985-01-01

    The various questions regarding bacteriological investigations within the scope of forensic autopsies are discussed in the light of our own cases and with regard to the relevant literature: estimate of the age of the corpse on the basis of decomposition changes caused by bacteria; determination of so-called bacteriograms from the point of view of criminalistics; supplementary investigations of the cause of death. Iatrogenic infections (e.g., gangrene) are gone into in more detail, as is so-called infantile botulism within the scope of the "sudden infant death syndrome". Finally, it is pointed out that when doing forensic autopsies, thought should also be given to illnesses that have only been known for a few years, examples being legionnaires' disease and the toxic shock syndrome ("tampon sickness").

  18. Imaging and virtual autopsy: looking back and forward

    OpenAIRE

    Bolliger, Stephan A; Thali, Michael J

    2015-01-01

    In order to create a three-dimensional (3D) documentation of findings which can be reassessed if necessary by other experts, the research project ‘Virtopsy®’ was launched in the late 1990s. This project combined autopsy results with forensic imaging in the form of computed tomography, magnetic resonance tomography and 3D surface scanning. The success of this project eventually succeeded in convincing the courts in Switzerland to accept these novel methods as evidence. As opposition towards au...

  19. Respiratory outcomes among South African coal miners at autopsy

    Energy Technology Data Exchange (ETDEWEB)

    Naidoo, R.N.; Robins, T.G.; Murray, J. [University of KwaZulu Natal, Durban (South Africa). Center for Occupational & Environmental Health

    2005-09-01

    Studies of dose-response relationships between respiratory outcomes at autopsy and coal dust exposure are limited. The Pathology Automation System (PATHAUT) database of South African miners, is one of the largest autopsy databases of occupational lung disease. This study described the prevalence of respiratory outcomes among South African coal miners at autopsy, and determined whether dose response relationships existed between emphysema and exposure. Autopsies conducted from 1975 to 1997 on coal miners with exclusive coal mining exposure and having exposure duration information (n = 3,167) were analyzed from PATHAUT Logistic regression was used to determine relationships between exposure and outcomes, controlling for race, smoking and age on a subset for whom smoking history was available (n = 725). The prevalence of silicosis, tuberculosis (TB), coal workers' pneumoconiosis (CWP), and moderate and marked emphysema were 10.7%, 5.2%, 7.3%, and 64%, respectively. All diseases, except TB, were associated with exposure duration. Black miners had 8.3 and 1.2 fold greater risks for TB and CWP, respectively, than white miners. White miners had an increased risk of 1.4 and 5.4 for silicosis and moderate to marked emphysema, respectively. In models unadjusted for age, and including smoking, moderate to marked emphysema was strongly associated with exposure duration (OR = 3.4; 95% CI = 1.9-5.9 for highest tercile of exposure duration). Exposure-related risk estimates were reduced when age was introduced into the model. However age and duration of exposure were highly correlated, = 0. 68) suggesting a dilution of the exposure effect by age. There were significant dose related associations of disease, including emphysema, with coal dust exposure.

  20. Guidelines for autopsy investigation of sudden cardiac death

    DEFF Research Database (Denmark)

    Basso, Cristina; Aguilera, Beatriz; Banner, Jytte

    2017-01-01

    Pathology has developed these guidelines, which represent the minimum standard that is required in the routine autopsy practice for the adequate investigation of SCD. The present version is an update of our original article, published 10 years ago. This is necessary because of our increased understanding...... blocks and appropriate material for toxicology, microbiology, biochemistry, and molecular investigation. Our recommendations apply to university medical centers, regionals hospitals, and all healthcare professionals practicing pathology and forensic medicine. We believe that their adoption throughout...

  1. Autopsy observations in lethal short-rib polydactyly syndromes.

    Science.gov (United States)

    Okiro, Patricia; Wainwright, Helen; Spranger, Jürgen; Beighton, Peter

    2015-01-01

    The short rib-polydactyly syndromes are a heterogeneous group of lethal autosomal recessive disorders (SRP I-IV), which result from cellular ciliary dysfunction during embryogenesis. Diagnosis is conventionally based on radiographic imaging. Since 1976, postmortem investigations of 5 affected fetuses or stillbirths have been undertaken and the visceral abnormalities have been documented. These anomalies are discussed in the context of prenatal differential diagnosis and prognostication following imaging in pregnancy and at autopsy following miscarriage or stillbirth.

  2. Guidelines for autopsy investigation of sudden cardiac death

    DEFF Research Database (Denmark)

    Basso, Cristina; Aguilera, Beatriz; Banner, Jytte

    2017-01-01

    Europe will improve the standards of autopsy practice, allow meaningful comparisons between different communities and regions, and permit the identification of emerging patterns of diseases causing SCD. Finally, we recommend the development of regional multidisciplinary networks of cardiologists......, geneticists, and pathologists. Their role will be to facilitate the identification of index cases with a genetic basis, to screen appropriate family members, and ensure that appropriate preventive strategies are implemented....

  3. Anomalies associated with single umbilical artery at perinatal autopsy.

    Science.gov (United States)

    Nayak, Shalini S; Shukla, Anju; Girisha, Katta M

    2015-01-01

    We evaluated 214 fetuses sent for autopsy with gestational ages ranging from 12 to 39 weeks. Of these, seventeen fetuses (7.9%) had single umbilical artery. Thirteen of these fetuses were aborted after antenatal detection of severe malformations and 4 died in utero. Genito-urinary system (n=6) and central nervous system (n=4) were the most common sites of involvement. Presence of single umbilical artery warrants a detailed evaluation of the fetus for other anomalies.

  4. VIRTOPSY: minimally invasive, imaging-guided virtual autopsy.

    Science.gov (United States)

    Dirnhofer, Richard; Jackowski, Christian; Vock, Peter; Potter, Kimberlee; Thali, Michael J

    2006-01-01

    Invasive "body-opening" autopsy represents the traditional means of postmortem investigation in humans. However, modern cross-sectional imaging techniques can supplement and may even partially replace traditional autopsy. Computed tomography (CT) is the imaging modality of choice for two- and three-dimensional documentation and analysis of autopsy findings including fracture systems, pathologic gas collections (eg, air embolism, subcutaneous emphysema after trauma, hyperbaric trauma, decomposition effects), and gross tissue injury. Various postprocessing techniques can provide strong forensic evidence for use in legal proceedings. Magnetic resonance (MR) imaging has had a greater impact in demonstrating soft-tissue injury, organ trauma, and nontraumatic conditions. However, the differences in morphologic features and signal intensity characteristics seen at antemortem versus postmortem MR imaging have not yet been studied systematically. The documentation and analysis of postmortem findings with CT and MR imaging and postprocessing techniques ("virtopsy") is investigator independent, objective, and noninvasive and will lead to qualitative improvements in forensic pathologic investigation. Future applications of this approach include the assessment of morbidity and mortality in the general population and, perhaps, routine screening of bodies prior to burial. Copyright RSNA, 2006.

  5. Imaging and virtual autopsy: looking back and forward.

    Science.gov (United States)

    Bolliger, Stephan A; Thali, Michael J

    2015-08-05

    In order to create a three-dimensional (3D) documentation of findings which can be reassessed if necessary by other experts, the research project 'Virtopsy®' was launched in the late 1990s. This project combined autopsy results with forensic imaging in the form of computed tomography, magnetic resonance tomography and 3D surface scanning. The success of this project eventually succeeded in convincing the courts in Switzerland to accept these novel methods as evidence. As opposition towards autopsies has grown over the last decades, Virtopsy also strives to find and elaborate additional methods which can answer the main forensic questions without autopsy. These methods comprise post-mortem angiography for illustration of the vascular bed and image-guided tissue and fluid sampling for histological, toxicological and microbiological examinations. Based on the promising results, post-mortem imaging, especially with 3D surface scanning, has meanwhile also been applied to living victims of assault, who have suffered patterned injuries due to bites, blows with objects, etc. In our opinion, forensic imaging is an objective method which offers the possibility for a reassessment of the findings by other experts, even after burial or cremation of the corpse, or healing of the injuries in living victims, thus leading to a greater security in court. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

  6. Cerebral infarction in autopsies of chagasic patients with heart failure

    Directory of Open Access Journals (Sweden)

    Roque Aras

    2003-10-01

    Full Text Available OBJECTIVE: To determine the frequency of encephalic infarction and its contribution to lethality in patients with Chagas' disease and heart failure. METHODS: Medical records and autopsy reports of patients with Chagas' disease complicated by heart failure, who died at the Professor Edgar Santos Hospital of the Federal University of Bahia in the past 45 years were retrospectively analyzed. Data comprised information regarding the clinical history on hospital admission, complementary and anatomicopathological examinations, including the presence of encephalic infarction, the impaired region, and the cause of death. RESULTS: Of the 5,447 autopsies performed, 524 were in patients with heart failure due to Chagas' disease. The mean age was 45.7 years, and 51 (63% patients were of the male sex. The frequency of encephalic infarction was 17.5%, corresponding to 92 events in 92 individuals, 82 (15.8% of which involved the brain, 8 (1.5% involved the cerebellum, and 2 (0.4% involved the hypophysis. CONCLUSION: Cerebral infarction has been a frequent finding in autopsies of chagasic patients with heart failure, and it has been an important cause of death in our region. The presence of cerebral infarction and its complications have been associated with death in 52% of the cases studied.

  7. Suicides among Serbian war veterans: An autopsy study

    Directory of Open Access Journals (Sweden)

    Mihailović Zoran

    2015-01-01

    Full Text Available Introduction. The risk of suicide among war veterans is a controversial issue, where findings so far have been contradictory. Objective. This study focusses on suicide in Serbian veterans from the wars in former Yugoslavia in the 1990s in order to create appropriate preventive measures and reduce the number of these fatal cases. Methods. The autopsy protocols of all 44 suicides committed by war veterans in the Belgrade District population over a period between 1992 and 2000 were investigated. Data were obtained from autopsy records, results of toxicological investigations and psychological autopsy protocols. Results. Symptoms of posttraumatic stress disorder were present in 27.3%, major depression in 9.1% and schizophrenia in 6.8% of veterans. The majority of suicides (84.1% were committed by recruits in the Yugoslav National Army, spending between three and eight months in the zone of war operations. Six committed suicide during the first 30 days after their war activities, while the majority of suicides occurred between five and six years after combat. The most frequent manner of suicide was the use of handguns (56.8% and bombs (18.2%. Conclusion. The results of this research may give useful information about the individuals with the highest suicidal risk in order to alleviate the consequences of war psychotraumas in veterans and prevent their growth into a permanent handicap or suicide. [Projekat Ministarstva nauke Republike Srbije, br. OI 175093

  8. Validation of autopsy data for epidemiologic studies of coal miners

    Energy Technology Data Exchange (ETDEWEB)

    Naidoo, R.N.; Robins, T.G.; Murray, J.; Green, F.H.Y.; Vallyathan, V. [University of KwaZulu Natal, Durban (South Africa). Center for Occupational & Environmental Health

    2005-01-01

    South Africa has one of the largest miner autopsy databases, PATHAUT dating back to 1925. The diagnoses recorded on this database have never been evaluated for coal miners. The objective was to determine the validity of the autopsy diagnoses for coal workers, specifically bronchitis, silicosis, tuberculosis, coal workers' pneumoconiosis and emphysema, from 1975 to 1997. Three pathologists experienced in miner respiratory pathology conducted the review. They were blinded to employment and medical histories as well as to previous pathological diagnoses on PATHAUT and reviewed 28 coal miners with mixed mining exposures, and 31 cases with exclusive coal mine exposure-all selected randomly. The reviewers' independent and consensus diagnoses were compared to PATHAUT. An additional 31 cases with available whole mount sections were reviewed for the diagnosis of emphysema. Kappa statistics were used to determine degrees of agreement among reviewers and between reviewers and PATHAUT. This, the first systematic review of PATHAUT autopsy diagnoses made on coal workers, showed that PATHAUT can be used with confidence to establish a diagnosis of moderate to severe grades of coal workers' pneumoconiosis. The grade of emphysema recorded on PATHAUT could be used for epidemiological purposes, when whole mount sections have been prepared.

  9. Acute erythroid leukemia: autopsy report of a rare disease

    Directory of Open Access Journals (Sweden)

    Cristiane Rúbia Ferreira

    2011-12-01

    Full Text Available Acute erythroid leukemia (AEL is a rare subtype of acute myeloid leukemia(AML, characterized by predominant erythroid proliferation. The 2008 WorldHealth Organization (WHO classification of AML defined two AEL subtypes:erythroleukaemia (EL, in which erythroid precursors account for 50% or moreof all nucleated bone marrow cells and myeloblasts account for 20% or more ofthe nonerythroid cell population; and pure erythroid leukemia (PEL, in whicherythroid precursors account for 80% or more of all nucleated bone marrowcells. We report the case of an elderly female patient with wasting syndromeand pancytopenia without evidence of blasts in peripheral blood. A diagnosisof PEL was established on the basis of bone marrow biopsy findings. Thepatient died on postadmission day 20, and an autopsy was performed. Wereclassified the disease as EL on the basis of the autopsy findings, whichincluded myeloblasts accounting for more than 20% of the nonerythroid cellsin the bone marrow, as well as leukemic infiltration and myeloid metaplasia insolid organs, such as the liver, spleen, kidneys, adrenal glands, and abdominallymph nodes. A rare disease, AEL accounts for less than 5% of all AMLs and ispractically a diagnosis of exclusion. Autopsy reports of AEL are extremely rarein the literature. We demonstrate that in the case reported here, leukemia cellstended to infiltrate solid organs with myeloid metaplasia. Our findings alsoshow that a larger neoplastic bone marrow sample is crucial to the correctdiagnosis of EL, which is based on morphological and quantitative criteria.

  10. Imaging and virtual autopsy: looking back and forward

    Science.gov (United States)

    Bolliger, Stephan A.; Thali, Michael J.

    2015-01-01

    In order to create a three-dimensional (3D) documentation of findings which can be reassessed if necessary by other experts, the research project ‘Virtopsy®’ was launched in the late 1990s. This project combined autopsy results with forensic imaging in the form of computed tomography, magnetic resonance tomography and 3D surface scanning. The success of this project eventually succeeded in convincing the courts in Switzerland to accept these novel methods as evidence. As opposition towards autopsies has grown over the last decades, Virtopsy also strives to find and elaborate additional methods which can answer the main forensic questions without autopsy. These methods comprise post-mortem angiography for illustration of the vascular bed and image-guided tissue and fluid sampling for histological, toxicological and microbiological examinations. Based on the promising results, post-mortem imaging, especially with 3D surface scanning, has meanwhile also been applied to living victims of assault, who have suffered patterned injuries due to bites, blows with objects, etc. In our opinion, forensic imaging is an objective method which offers the possibility for a reassessment of the findings by other experts, even after burial or cremation of the corpse, or healing of the injuries in living victims, thus leading to a greater security in court. PMID:26101279

  11. Carbon Monoxide Poisoning Cases Autopsied in South Marmara Region

    Directory of Open Access Journals (Sweden)

    Filiz Eren

    2014-10-01

    Full Text Available Carbonmonoxide (CO related deaths, which are generally preventable accidents that include accidents due to the coal stoves and water heaters in bath at home, the mining accidents, and other accidents. CO accept as the most common cause of poisoning cases in many countries and its prominent feature is being a colorless, odorless and nonirritant gas. In the period from 2007 until the end of 2011, the autopsy records of the ........ of Turkey were reviewed. Over a period of 5 years a total of 5782 autopsies were done of which 218 involved CO poisoning, constituting 3,8 % of total cases. Information regarding age, sex, month, year, and as well as various aspects were examined. Study data were encoded with computer and Statistical analysis was performed using SPSS for windows program. Of the cases 76 were (34,9% female, 142 were (65,1% male and male/female ratio was 1,9. Of the cases average age was 46.8, range between 1 and 90 years. 57,8% of deaths were in winter markedly. The highest carboxyhemoglobin saturation was 92% in the blood. Poisoning due to CO leaks from coal heaters is an important problem in our country and surrounding regions. The mining accidents should be reduced by increasing safety in the workplace. We must more expend efforts to educate the public and prevent CO poisoning. Key words: Carbon monoxide, poisoning, autopsy.

  12. Contrast-enhanced postmortem computed tomography in clinical pathology: enhanced value of 20 clinical autopsies.

    Science.gov (United States)

    Westphal, Saskia E; Apitzsch, Jonas C; Penzkofer, Tobias; Kuhl, Christiane K; Mahnken, Andreas H; Knüchel, Ruth

    2014-09-01

    Postmortem computed tomography (PMCT) is a modern tool that complements autopsy diagnostics. In clinical autopsies, a major cause of death is cardiovascular disease. To improve the performance of PMCT in cardiovascular disease, full body angiography was developed (PMCT angiography [PMCTA]). Twenty PMCTA scans generated before autopsy were compared with native PMCT and clinical autopsy. The objective of the study was to quantify the additional diagnostic value of adding angiography to native imaging and to compare PMCT and PMCTA findings to autopsy findings. The diagnosis of the cause of death was identical or overlapped in 80% of the cases that used PMCTA and 70% that used PMCT. The additional diagnostic yield given by PMCT and PMCTA in combination with autopsy was 55%. PMCT yielded additional diagnoses in the musculoskeletal system. The greatest additional diagnostic value of PMCTA was in association with cardiovascular diagnoses. The accuracy of PMCTA for cardiac causes of death was 80%, and the positive predictive value was 90%. The findings indicate that native PMCT cannot display the cardiovascular system sufficiently clearly for high-quality diagnostic assessment. However, PMCTA is a powerful tool in autopsy cases with a history of cardiovascular disease and/or a suspected cardiovascular cause of death. The combination of PMCTA and clinical autopsy enhances diagnostic quality and completeness of the autopsy report. Furthermore, in cases without consent or with a restricted consent for clinical autopsy, PMCTA has the potential to provide information on cardiovascular causes of death. Copyright © 2014 Elsevier Inc. All rights reserved.

  13. The eAutopsy: an effective virtual tool for exposing medical students to the postmortem examination.

    Science.gov (United States)

    Talmon, Geoffrey A; Czarnecki, Donna; Bernal, Kerry

    2014-11-01

    One reason for declining autopsy numbers is clinicians' lack of familiarity with the practice. We developed an online tool used in place of attending postmortem examinations and aimed to determine if the experience was as effective in affecting medical students' attitudes toward the procedure. The eAutopsy was a part of a unit consisting of a mixture of a didactic lecture, readings, and online discussion board. A class of second-year medical students was randomly distributed between autopsy attendance and the eAutopsy, afterward completing a Likert-type attitudinal survey. Responses were compared with previous students receiving only a lecture. Thirty students attended a "live" autopsy, 90 completed the eAutopsy, and 47 students from the prior year completed the survey. Responses between all three were statistically similar for all but one item. The live and eAutopsy groups would be significantly more comfortable asking for an autopsy in the future. Narrative responses indicated that while the eAutopsy was effective in delivering information, some noticed the lack of emotional impact. The two forms of autopsy exposure performed similarly on a Likert-type survey assessing certain attitudes related to the procedure. However, the emotional impact of the live experience may be longer lasting. Copyright© by the American Society for Clinical Pathology.

  14. Intracardiac thrombi in extracardiac disorders: an autopsy study.

    Science.gov (United States)

    Vaideeswar, Pradeep; Divate, Smita; Harke, Megha

    2012-01-01

    Intracardiac thrombi (ICT), more commonly encountered at autopsy, are well documented with underlying cardiovascular disease. Occurrence of ICT in systemic diseases without an intrinsic cardiac disorder is rare. The aim of this autopsy study was to highlight such an occurrence. From 1996 to 2010, cases with ICT unrelated to primary cardiac disorders were selected at autopsy and analyzed. Clinical and investigational data were obtained from the medical records. The location, morphology, size, and histological appearance of the thrombi were noted. The thrombi were then classified on the basis of their location, nature, and histology (fresh and/or organized); this was correlated with the clinical setting. Among a total of 11,724 autopsies performed in 15 years, 276 patients (2.4%) had ICT. Of these, 45 patients (0.4%) had ICT that were unrelated to primary cardiac diseases. There were 25 men and 20 women with a mean age of 46.1 years. Antemortem diagnosis was not made in any of these patients. Eight patients each (35.6%) showed isolated left-sided and multichambered involvement, while the rest of the hearts (64.4%) had thrombi in the right-sided chamber(s). The recognizable risk factors were underlying cancers (24.4%), prolonged immobilization (20%), systemic lupus erythematosus (6.7%), pregnancy (4.4%), nephropathy (4.4%), primary antiphospholipid antibody syndrome (2.2%), and ulcerative colitis (2.2%). However, 16 patients (35.7%) had no obvious predisposing factor, although investigations for prothrombotic markers had not been done. Diabetes mellitus, chronic alcoholism, and deep vein thrombosis of the lower limbs had been clinically documented in some of them. The cause of death in most patients (73.3%) had been related to pulmonary and/or systemic thromboembolism. This autopsy study emphasizes the great need for a higher index of suspicion of in situ thrombosis in the heart in hypercoagulable states so as to curtail the morbidity and mortality of the primary

  15. Alcohol and premature death in Estonian men: a study of forensic autopsies using novel biomarkers and proxy informants

    Science.gov (United States)

    2012-01-01

    Background Alcohol makes an important contribution to premature mortality in many countries in Eastern Europe, including Estonia. However, the full extent of its impact, and the mechanisms underlying it, are challenging issues to research. We describe the design and initial findings of a study aimed at investigating the association of alcohol with mortality in a large series of forensic autopsies of working-age men in Estonia. Methods 1299 male deaths aged 25-54 years were subject to forensic autopsy in 2008-2009. The routine autopsy protocol was augmented by a more systematic inspection of organs, drug testing, assay of liver enzymes and novel biomarkers of alcohol consumption (EtG, EtS and PEth), together with proxy interviews with next of kin for deaths among men who lived in or close to a major town. Results 595 augmented autopsies were performed. Of these, 66% were from external causes (26% suicide, 25% poisoning). 17% were attributed to circulatory system diseases and 7% to alcoholic liver disease. Blood alcohol concentrations (BAC) of ≥ 0.2 mg/g were found for 55% of deaths. Interviews were conducted with proxy informants for 61% of the subjects who had resided in towns. Of these, 28% were reported in the previous year to have been daily or almost daily drinkers and 10% had drunk non-beverage alcohols. Blood ethanol and the liver enzyme GGT were only associated with daily drinking. However, the novel biomarkers showed a more graded response with recent consumption. In contrast, the liver enzymes AST and ALT were largely uninformative because of post-mortem changes. The presence of extremely high PEth concentrations in some samples also suggested post-mortem formation. Conclusion We have shown the feasibility of deploying an extended research protocol within the setting of routine forensic autopsies that offer scope to deepen our understanding of the alcohol-related burden of premature mortality. The most unique feature of the study is the information on a

  16. The Carolina Center of Cancer Nanotechnology Excellence: past accomplishments and future perspectives.

    Science.gov (United States)

    Juliano, Rudy L; Sunnarborg, Susan; DeSimone, Joseph; Haroon, Zishan

    2011-01-01

    The Carolina Center of Cancer Nanotechnology Excellence (C-CCNE) is funded by the National Cancer Institute and is based at the University of North Carolina. The C-CCNE features interactions between physical and biological scientists in a series of projects and cores that work together to quickly harness innovations in nanotechnology for the early diagnosis and treatment of cancer. Two key focus areas of the C-CCNE are, first, the selective delivery of drugs and imaging agents utilizing advanced nanoparticle technology, and second, novel approaches to imaging and radiotherapy utilizing carbon nanotube-based x-ray sources.

  17. An exploratory study of the pattern of consent for autopsy in a regional hospital setting.

    LENUS (Irish Health Repository)

    Kaar, T K

    2012-02-03

    A prospective study of the pattern of responses to requests for autopsy in a general surgical unit was performed. Information on the characteristics of the deceased, of the requestee and of the requester was documented in the case of 66 patients who died while in hospital. Permission to perform autopsy was not requested in 39 out of 66 cases and this was the most frequent contributory factor to the low rate of autopsy. Once a decision to grant or refuse autopsy is made by relatives of the deceased, the decision is unlikely to be reversed. Permission to perform autopsy was more likely to be sought when the deceased was male than when deceased was female. The relatives of patients who had recently undergone surgery were more likely to refuse permission for autopsy than were those of patients who had not had recent surgery.

  18. Locational characteristics of the increasing number of forensic autopsy cases in Kyoto, Japan.

    Science.gov (United States)

    McLean, Stuart; Nanba, Hiroko; Ikegaya, Hiroshi

    2012-04-01

    In Japan, the definition of unnatural death is not prescribed in law. However, a legal judgment recently defined unnatural death as all deaths, excluding natural deaths and deaths from diseases. Legally, unnatural deaths must be reported to the police. In the case of a reported death being considered as suspicious by the police, a forensic autopsy is required. The number of autopsies and the autopsy rate in Japan and Kyoto has increased over the last 10 years. Using data collected from 221 autopsy cases between 2008 and 2010 in Kyoto, Japan, the characteristics of locations where autopsy cases were discovered were analysed to identify reasons for the increase in autopsy numbers. It was found that factors including amount of human interaction and socioeconomic factors may help to explain the statistically significant correlations found.

  19. The Regional Autopsy Center: The University of Alabama at Birmingham Experience.

    Science.gov (United States)

    Atherton, Daniel Stephen; Reilly, Stephanie

    2017-09-01

    Rates of autopsied deaths have decreased significantly for the last several decades. It may not be practical for some institutions to maintain the facilities and staffing required to perform autopsies. In recent years, the University of Alabama at Birmingham (UAB) has established contracts to perform autopsies for several regional institutions including the Alabama Department of Forensic Sciences (ADFS), the United States Veterans Affairs, the local prison system, local community hospitals, and with families for private autopsy services. Contracts and autopsy data from 2004 to 2015 were obtained and reviewed. Since 2004, the number of UAB hospital autopsies trended slightly downward. On average, UAB hospital cases comprised most yearly cases, and the ADFS was the second largest contributor of cases. Income generated from outside autopsies performed from 2006 to 2015 totaled just more than 2 million dollars, and most of the income was generated from referred ADFS cases. This study provides evidence that a centralized institution (regional autopsy center [RAC]) can provide regional autopsy service in a practical, feasible, and economically viable manner, and a RAC can benefit both the referring institutions as well as the RAC itself.

  20. Use of cytology as an auxiliary diagnostic tool in autopsies.

    Science.gov (United States)

    Andrade, Luana; Massarente, Vitória Lana; Tormin, Stéphanie Corradini; Ribeiro, Karina Braga; Pozzan, Geanete; Saieg, Mauro Ajaj

    2016-11-01

    The use of minimally invasive procedures in autopsies such as image-guided fine-needle aspiration may facilitate family acceptance and, therefore, increase the number of postmortem examinations. The objective of the current study was to validate the use of cytology in a prospective set of conventional autopsies. All lesions and organs sampled for histological examination were concomitantly evaluated by scrape cytology of exactly the same location. The cytopathologist and the surgical pathologist were blinded to each other's microscopic findings. Final cytological and histological diagnoses were divided into 6 main diagnostic groups: normal, neoplasms (benign and malignant), inflammatory conditions, adaptive processes, degeneration, and cardiovascular disorders. Cytohistological agreement was assessed with Cohen's κ coefficient. The simple percentage agreement was also reported for each diagnostic group and for all different organs sampled in the postmortem examinations. Two hundred eleven samples were studied from 36 consecutive autopsies (21 males and 15 females; median age, 58 years). Complete cytohistological agreement was achieved for 151 samples (71.6%) with a κ coefficient of 0.43 (moderate correlation). When samples were divided by diagnostic group, the best results were seen in normal specimens (93.8%) and neoplasms (82.3%). Organs with the best performance included the thyroid, cerebellum, lymph nodes, and adrenal glands (all with 100% agreement), the brain (90.5%), and the pancreas (84.6%). Cytology showed a good correlation with histology, particularly for neoplastic cases and specimens with minimal pathological alterations, and could be used as an alternative diagnostic method in partial or restricted postmortem examinations. Cancer Cytopathol 2016;124:785-90. © 2016 American Cancer Society. © 2016 American Cancer Society.

  1. Primary diffuse leptomeningeal gliomatosis: An autopsy case report

    Directory of Open Access Journals (Sweden)

    Shaik Afshan Jabeen

    2014-01-01

    Full Text Available Primary diffuse leptomeningeal gliomatosis (PDLG is a rare condition, characterized by infiltration of the meninges by glial cells without evidence of the primary tumor in the brain or spinal cord parenchyma. Glioma arising primarily from the leptomeninges is extremely rare and often diagnosed only in post mortem examination and the diagnosis may be missed in meningeal biopsy. We describe a young female who presented with symptoms of raised intracranial pressure with imaging evidence of diffuse leptomeningeal enhancement in whom autopsy confirmed the diagnosis of PDLG. Our case illustrates the diagnostic difficulties in making the pre-mortem diagnosis even with multiple cerebrospinal fluid cytologies and leptomeningeal biopsy.

  2. Autopsy imaging for cardiac tamponade in a Thoroughbred foal.

    Science.gov (United States)

    Yamada, Kazutaka; Sato, Fumio; Horiuchi, Noriyuki; Higuchi, Tohru; Kobayashi, Yoshiyasu; Sasaki, Naoki; Nambo, Yasuo

    2016-01-01

    Autopsy imaging (Ai), postmortem imaging before necropsy, is used in human forensic medicine. Ai was performed using computed tomography (CT) for a 1-month-old Thoroughbred foal cadaver found in a pasture. CT revealed pericardial effusion, collapse of the aorta, bleeding in the lung lobe, gas in the ventricles and liver parenchyma, and distension of the digestive tract. Rupture in the left auricle was confirmed by necropsy; however, it was not depicted on CT. Therefore, Ai and conventional necropsy are considered to complement each other. The cause of death was determined to be traumatic cardiac tamponade. In conclusion, Ai is an additional option for determining cause of death.

  3. 76 FR 11522 - South Carolina Electric and Gas Company (SCE&G) and the South Carolina Public Service Authority...

    Science.gov (United States)

    2011-03-02

    ... COMMISSION South Carolina Electric and Gas Company (SCE&G) and the South Carolina Public Service Authority... Carolina Electric and Gas Company (SCE&G) acting as itself and agent for the South Carolina Public Service... application is available for public inspection at the Commission's Public Document Room (PDR), located at One...

  4. 76 FR 14436 - South Carolina Electric and Gas Company (SCE&G) and the South Carolina Public Service Authority...

    Science.gov (United States)

    2011-03-16

    ... COMMISSION South Carolina Electric and Gas Company (SCE&G) and the South Carolina Public Service Authority... Carolina Electric and Gas Company (SCE&G) acting as itself and agent for the South Carolina Public Service... application is available for public inspection at the Commission's Public Document Room (PDR), located at One...

  5. 76 FR 12998 - South Carolina Electric and Gas Company (SCE&G) and the South Carolina Public Service Authority...

    Science.gov (United States)

    2011-03-09

    ... COMMISSION South Carolina Electric and Gas Company (SCE&G) and the South Carolina Public Service Authority... Carolina Electric and Gas Company (SCE&G) acting as itself and agent for the South Carolina Public Service... application is available for public inspection at the Commission's Public Document Room (PDR), located at One...

  6. 76 FR 16456 - South Carolina Electric and Gas Company (SCE&G) and the South Carolina Public Service Authority...

    Science.gov (United States)

    2011-03-23

    ... COMMISSION South Carolina Electric and Gas Company (SCE&G) and the South Carolina Public Service Authority... Carolina Electric and Gas Company (SCE&G) acting as itself and agent for the South Carolina Public Service... application is available for public inspection at the Commission's Public Document Room (PDR), located at One...

  7. An autopsy-based study of death due to road traffic accidents in metropolis of Karachi.

    Science.gov (United States)

    Mirza, Farhat Hussain; Hassan, Qudsia; Jajja, Nadia

    2013-02-01

    To study the demographic distribution of the victims of road traffic accidents that were presented for medico-legal autopsy in Karachi, identify fatal injuries, the identity of road users autopsied and the month-wise variation in performing autopsies. Descriptive cross-sectional study of autopsies conducted at the mortuaries of Civil Hospital Karachi, Jinnah Postgraduate Medical Centre and Abbasi Shaheed Hospital between March 1,2008 and February 28, 2009. Bodies brought in by police for partial/external autopsy were excluded. Data was collected on pre-designed proformas and was statistically analysed using SPSS 15. Of the total 2090 autopsies performed in Karachi, 581 (27.8%) cases were victims of RTA. Of these RTA victims, 324 (55.8%) autopsies were of those between the ages of 19 and 40 years. There were 510 (87.8%) males and 71 (12.2%) females with a ratio of male: female being 7:1.This ratio was 4.2:1 for those aged 0-18 years and 11:1 for those aged 19-40 years (p = 0.05). Death was due to injury to the head in 386 (66.4%) victims, to the chest in 84 (14.5%) cases, multiple traumatic injuries in 50 (8.6%) and pelvis in 17 (2.9%) cases. The majority of the victims on whom autopsy was performed were pedestrians (n = 389, 67%) followed by motorcyclists (n = 122, 21%). On an average 48.4 +/- 7.46 autopsies were performed every month, and there was no statistically significant variation in autopsies on this count. There was a male preponderance, but the significant differences in two age groups need to be correlated with the incidence of RTAs in each sex in that age group and the compliance levels of getting females autopsied.

  8. Postmortem CT compared to autopsy in children; concordance in a forensic setting.

    Science.gov (United States)

    Sieswerda-Hoogendoorn, Tessa; Soerdjbalie-Maikoe, Vidija; de Bakker, Henri; van Rijn, Rick R

    2014-11-01

    The aim of this study is to assess the accuracy of postmortem CT (PMCT) in determining the cause of death in children who underwent a forensic autopsy because of a suspected nonnatural death. We selected forensic pediatric autopsies at the Netherlands Forensic Institute, whereby the subject underwent PMCT between 1-1-2008 and 31-12-2012. Cause of death was independently scored by a radiologist and a pathologist. Cause of death was classified (1) in categories being natural, unnatural, and unknown; (2) according to the ICD-10; and (3) according to institutional classification. In the study period, 189 pediatric forensic autopsies were performed. Fifteen were excluded because of putrefaction. Of the remaining 174 autopsies, 98 (56%) underwent PMCT. PMCT and autopsy identified the same category in 69/98 cases (70%, kappa 0.49). They identified the same cause of death in 66/98 cases (67%, kappa 0.5) using ICD-10; in 71/98 (72%, kappa 0.62) using a forensic classification. PMCT performed better in unnatural deaths (59-67 % agreement) than in natural deaths (0 % agreement). If no cause of death was detected with autopsy, PMCT failed to identify a cause of death in 98% (39/40). Pediatric PMCT does identify the majority of unnatural causes of death, but does not identify new diagnoses (true positives) if no cause of death is found during autopsy. Diagnostic accuracy in natural deaths is low. • The case mix is an important predictor for the concordance between PMCT and autopsy. • In case of an unnatural death, 72--81% of PMCT results matches autopsy results. • In case of a natural death, 0% of PMCT results matches autopsy results. • If no cause of death is identified with autopsy, 98% of PMCT results concurs.

  9. The Carolina Autism Transition Study (CATS)

    Science.gov (United States)

    2017-07-01

    AWARD NUMBER: W81XWH-15-1-0093 TITLE: The Carolina Autism Transition Study (CATS) PRINCIPAL INVESTIGATOR: Laura Carpenter, MD RECIPIENT...Carolina Autism Transition Study (CATS) 5b. GRANT NUMBER W81XWH-15-1-0093 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER Laura Carpenter...provides a description of the Year 2 progress made and plans for Year 3 for the project entitled “The Carolina Autism Transition Study (CATS).” The goal of

  10. Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literature.

    Science.gov (United States)

    Adsay, N Volkan; Andea, Aleodor; Basturk, Olca; Kilinc, Nihal; Nassar, Hind; Cheng, Jeanette D

    2004-06-01

    The vast majority of pancreatic carcinomas are primary, and, among these, more than 90% are of ductal origin. However, a variety of extrapancreatic tumors may involve the pancreas secondarily and may manifest different clinicopathological characteristics and outcomes. In this study, pathology material from 973 surgical specimens and 4955 adult autopsy cases was reviewed to identify the tumors metastatic to or secondarily involving the pancreas. Biliary and periampullary neoplasms and tumors confined to peripancreatic soft tissue were excluded. In the autopsy series, the pancreas was involved by tumor in 190 cases, and 81 of these were secondary tumors. These were predominantly of epithelial origin, most commonly from lung (34), followed by GI tract (20), kidney (4), breast (3), liver (2), ovary (1), and urinary bladder (1). In addition, there were six tumors of hematopoietic origin, two melanomas, two sarcomas, and two mesotheliomas. Among the 973 surgical specimens, 38 cases contained metastatic tumors to the pancreas. Of these, 11 were lymphomas, and the others were carcinomas of stomach (7), kidney (6), lung (2), liver, prostate, ovary, uterus (1 case of each), and a Merkel cell carcinoma. In addition, there were three malignant gastrointestinal stromal tumors and one retroperitoneal leiomyosarcoma. In conclusion, lung cancer is the most common source of metastasis to pancreas, followed by gastrointestinal carcinomas and lymphomas. These tumors are usually seen in patients with disseminated disease and are detected mainly in autopsies. Secondary tumors constitute about 4% of pancreatic specimens in the authors' surgical database. Approximately one-third of them are clinically mistaken as primary tumors of the pancreas. These are predominantly hematopoietic malignancies or carcinomas of renal or gastric origin. Secondary tumors should be entertained in both the clinical and pathological differential diagnosis of pancreatic neoplasia. Copyright 2004 Springer-Verlag

  11. An Autopsy Proven Child Onset Chronic Traumatic Encephalopathy.

    Science.gov (United States)

    Lee, Kyuho; Kim, Seong-Ik; Lee, Yujin; Won, Jae Kyung; Park, Sung-Hye

    2017-06-01

    Here we present an autopsy case of chronic traumatic encephalopathy (CTE) in a 36-year-old man. He had a history of febrile seizures at the age of four and was severely demented at age 10 when he was admitted to a mental hospital. He had suffered repetitive self-harm, such as frequent banging of the head on the wall in his hospital record, but he had no clear history between the ages of four and ten. Autopsy revealed global cerebral atrophy, including the basal ganglia, thalamus, hippocampus, amygdala, mammilary bodies and lateral geniculate bodies. This case showed typical pathological features of CTE. Phosphorylated tau (p-tau)-positive neurofibrillary tangles (NFTs) and neuropil threads (NT) we are widely distributed in the brain, especially in the depth of the cerebral sulci. NFT and NT were also found in the basal ganglia, thalamus, amygdala and brainstem. Scanty β-amyloid deposits were found in the motor and sensory cortices, but α-synuclein was completely negative in the brain. This example showed that CTE can occur in young ages and that even children can experience CTE dementia.

  12. Twenty cases of equine osteoarthrosis detected at autopsy.

    Science.gov (United States)

    Ohshima, K; Satake, S; Ono, M; Ajito, T; Okada, K; Numakunai, S

    1990-02-01

    A pathological study was performed on osteoarthrosis detected at autopsy in 20 horses whose ages ranged from 21 days to 17 years old. They were asymptomatic on the joints except in 3 animals, and autopsied after death or sacrificed due to accidental fracture or other diseases. Lesions of osteoarthrosis were recognized in all horses, which tended to increase in incidence and severity according to age. Lesions were concentrated at hinged joints such as the elbow, fetlock, and hock. Synovial fossae and ulcerative lesions were observed on each opposite articular cartilage, forming the so-called mirror image. Linear erosions regarded as a secondary one were frequently observed on the cartilages. Histologically, the lesions were classified into 4 phases, 1) edematous degeneration, 2) crevice formation, focal necrosis, erosion of cartilage, 3) ulcerative changes, 4) regenerative changes of cartilage in foals and proliferation of fibrous or adipose tissue on the denuded subchondral bone in aged horses. By toluidine blue stain, decreased acid mucopolysaccharide was suggested in cartilaginous matrix around the lesions. From the results, it was concluded that the disease was a disorder of articular cartilage accompanied with hypoplasia of articular subchondral bone.

  13. Fetal ascites. A report of 3 autopsy cases.

    Science.gov (United States)

    Sakamoto, A; Matsuo, K; Kawai, K; Yoshida, K; Fukuda, K; Nakano, M; Nakatani, A; Tsuchiyama, H; Tagawa, H

    1987-09-01

    Three rare autopsy cases of fetal ascites were presented and the etiology of each case was described. Case 1 was a male neonate, delivered by cesarean section at 32 weeks' gestation, and died of respiratory failure. The abdomen was remarkably distended with 1020 ml of ascites. The etiology of Case 1 remained unknown even after macroscopic and microscopic examinations. We considered this as "idiopathic" fetal ascites. Case 2 was a female neonate, delivered at 31 weeks' gestation, with marked abdominal distension and cyanosis. Autopsy revealed 435 ml of ascites, and she was considered to have had "polysplenia syndrome" with cardiovascular malformations. Intrauterine heart failure due to cardiac anomalies was thought to be the cause of this ascites. In case 3 embryotomy was carried out under the diagnosis of fetal ascites by ultrasound examination at 22 weeks' gestation. An urachal cyst connected to the dilated urinary bladder and deficiency of musculature of the abdominal wall composed of loose connective tissue with calcification were observed. The abdominal wall was ruptured and 1,960 ml of ascites was measured. Polycystic kidney with renal dysplasia was also found. Case 3 showed "Prune-Berry syndrome" and fetal ascites may have arisen from these anomalies.

  14. Drowning investigated by post mortem computed tomography and autopsy

    DEFF Research Database (Denmark)

    Leth, Peter Mygind; Madsen, Betina Hauge

    2017-01-01

    Case control study of drowning fatalities investigated with autopsy and post mortem computed tomography (PMCT). 40 drowning fatalities (25 men, 15 women; 24 salt water, 16 fresh water) and 80 controls were included. The aim was to investigate the difference in lung tissue density (g/liter) and ra......Case control study of drowning fatalities investigated with autopsy and post mortem computed tomography (PMCT). 40 drowning fatalities (25 men, 15 women; 24 salt water, 16 fresh water) and 80 controls were included. The aim was to investigate the difference in lung tissue density (g....../liter) and radio opacity between drowning cases compared to control cases and to determine if it was possible to differentiate saltwater and freshwater drowning by measuring a difference in radio density of blood in the hearth chambers or great vessels before and after passage through the lungs of a drowned...... equal in drowning cases compared to controls, illustrating the phenomenon knows as “emphysema aquosum”. The physiological explanation could be washing out of surfactant by the drowning media, resulting in atelectasis and trapping of air in the peripheral lung regions. It was not possible to separate...

  15. Primary malignant pericardial sarcomatoid mesothelioma: An autopsy report.

    Science.gov (United States)

    Muta, Hiroko; Sugita, Yasuo; Ohshima, Koichi; Otsubo, Hitoshi

    2017-06-01

    Primary malignant pericardial sarcomatoid mesothelioma (PMPSM) is an extremely rare tumor with poor prognosis. We present an autopsy case in an 80-year-old man admitted for heart failure after one month of treatment at an outpatient clinic. He died three months after symptom onset. A complete autopsy revealed localization of the tumor to the pericardium without other lesions. Histologically, mainly spindle-shaped atypical cells with hyperchromatic nuclei and nucleoli were observed. Immunohistochemical markers for mesothelioma were positive for calretinin, cytokeratin AE1/AE3, and cytokeratin CAM5.2. Thus, we diagnosed primary sarcomatoid malignant mesothelioma of the pericardium. To our knowledge, only four PMPSM cases have been reported in the English literature in the past 30 years. Although PMPSM is rare, clinicians and pathologists should recognize it as a possible diagnosis of pericardial tumors. It is necessary to accumulate clinical and pathological diagnostic findings to establish early detection methods for this extremely rare disease. © 2017 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.

  16. Causes of death in forensic autopsy cases of malnourished persons.

    Science.gov (United States)

    Suzuki, Hideto; Tanifuji, Takanobu; Abe, Nobuyuki; Fukunaga, Tatsushige

    2013-01-01

    Medical examiners and forensic pathologists often encounter emaciated bodies in postmortem examinations. However, the main disease that caused death is often not clear and measures to prevent the unexpected death of malnourished persons have not been established. In this study, we examined the underlying causes of death among a large number of forensic autopsy cases that showed emaciation to clarify the features of sudden, unexpected death in malnourished persons. Documents of autopsy cases without putrefaction handled during 2007-2010 by the Tokyo Medical Examiner's Office were reviewed (n=7227). The body mass index (BMI) was calculated for each case. The causes of death for cases with severe malnutrition (BMIautopsy cases of malnourished persons show various causes of death, physicians have to pay more attention in making death diagnosis in such cases. From a preventative point of view, early detection of organic diseases, a better approach toward managing psychiatric diseases, and implementation of vaccination for pneumonia will contribute to reduction of future unexpected deaths among malnourished persons. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  17. [Workshop for coordinating South Carolina`s pre-college systemic initiatives in science and mathematics

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-31

    On December 19, 1991, South Carolina`s Governor, established the Governor`s Mathematics and Sciences Advisory Board (MSAB) to articulate a vision and develop a statewide plan for improving science and mathematics education in South Carolina. The MSAB recognized that systemic change must occur if the achievement levels of students in South Carolina are to improve in a dramatic way. The MSAB holds two fundamental beliefs about systemic change: (1) All the elements of the science and mathematics education system must be working in harmony towards the same vision; and (2) Each element of the system must be held against high standards and progress must be assessed regularly against these standards.

  18. Fourier series

    CERN Document Server

    Tolstov, Georgi P

    1962-01-01

    Richard A. Silverman's series of translations of outstanding Russian textbooks and monographs is well-known to people in the fields of mathematics, physics, and engineering. The present book is another excellent text from this series, a valuable addition to the English-language literature on Fourier series.This edition is organized into nine well-defined chapters: Trigonometric Fourier Series, Orthogonal Systems, Convergence of Trigonometric Fourier Series, Trigonometric Series with Decreasing Coefficients, Operations on Fourier Series, Summation of Trigonometric Fourier Series, Double Fourie

  19. Post-mortem imaging compared with autopsy in trauma victims--A systematic review.

    Science.gov (United States)

    Jalalzadeh, Hamid; Giannakopoulos, Georgios F; Berger, Ferco H; Fronczek, Judith; van de Goot, Frank R W; Reijnders, Udo J; Zuidema, Wietse P

    2015-12-01

    Post-mortem imaging or virtual autopsy is a rapidly advancing field of post-mortem investigations of trauma victims. In this review we evaluate the feasibility of complementation or replacement of conventional autopsy by post-mortem imaging in trauma victims. A systematic review was performed in compliance with the PRISMA guidelines. MEDLINE, Embase and Cochrane databases were systematically searched for studies published between January 2008 and January 2014, in which post-mortem imaging was compared to conventional autopsy in trauma victims. Studies were included when two or more trauma victims were investigated. Twenty-six studies were included, with a total number of 563 trauma victims. Post-mortem computer tomography (PMCT) was performed in 22 studies, post-mortem magnetic resonance imaging (PMMRI) in five studies and conventional radiography in two studies. PMCT and PMMRI both demonstrate moderate to high-grade injuries and cause of death accurately. PMCT is more sensitive than conventional autopsy or PMMRI in detecting skeletal injuries. For detecting minor organ and soft tissue injuries, autopsy remains superior to imaging. Aortic injuries are missed frequently by PMCT and PMMRI and form their main limitation. PMCT should be considered as an essential supplement to conventional autopsy in trauma victims since it detects many additional injuries. Despite some major limitations, PMCT could be used as an alternative for conventional autopsy in situations where conventional autopsy is rejected or unavailable. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  20. A 23-year review of sudden natural death autopsies in the Niger ...

    African Journals Online (AJOL)

    Background: Death occurring suddenly especially when the victim was active and recently fit, call for attention and thorough investigation to rule out secret homicide. Aim: To study the pattern of sudden natural death in the Niger Delta region of Nigeria. Methodology: The coroner's autopsy reports and hospital autopsy ...

  1. An erroneous opinion on a cause of death in a forensic autopsy: a ...

    African Journals Online (AJOL)

    Objective: To highlight the problem of accuracy in determining the cause of death in forensic autopsy. Case history: A 19- ... and manner of death. Conclusion: An erroneous opinion was reached regarding cause and manner of death in this autopsy report. ..... covered with black ink in the sketch diagram. Conflict of interest.

  2. The presence of enterovirus, adenovirus, and parvovirus B19 in myocardial tissue samples from autopsies

    DEFF Research Database (Denmark)

    Nielsen, Trine Skov; Hansen, Jakob; Nielsen, Lars Peter

    2014-01-01

    of adenovirus, enterovirus, and parvovirus B19 (PVB) in myocardial autopsy samples from myocarditis related deaths and in non-inflamed control hearts in an effort to clarify their significance as the causes of myocarditis in a forensic material. METHODS: We collected all autopsy cases diagnosed with myocarditis...

  3. Postmortem CT compared to autopsy in children; concordance in a forensic setting

    NARCIS (Netherlands)

    Sieswerda-Hoogendoorn, Tessa; Soerdjbalie-Maikoe, Vidija; de Bakker, Henri; van Rijn, Rick R.

    2014-01-01

    The aim of this study is to assess the accuracy of postmortem CT (PMCT) in determining the cause of death in children who underwent a forensic autopsy because of a suspected nonnatural death. We selected forensic pediatric autopsies at the Netherlands Forensic Institute, whereby the subject

  4. What do parents want to know when considering autopsy for their child with cancer?

    Science.gov (United States)

    Wiener, Lori; Sweeney, Corinne; Baird, Kristin; Merchant, Melinda S; Warren, Katherine E; Corner, Geoffrey W; Roberts, Kailey E; Lichtenthal, Wendy G

    2014-08-01

    Research has suggested that autopsy in pediatrics is a valued way for parents to better understand and process their child's death, yet physicians often express hesitancy in discussing this topic with parents. To better assist clinicians with initiating discussion about this often sensitive topic, the current study examined bereaved parents' preferences about the timing and content of the autopsy discussion as well as reasons for considering autopsy. This study explored the views of 30 parents who lost a child to a variety of malignancies between 6 months and 6 years ago. Results showed that 36.7% of parents recalled having a discussion about autopsy, and the vast majority of those who did not recall a discussion (89.5%) would have considered an autopsy if it had been discussed. The majority of participants in this study indicated their preference to have the first conversation about autopsy when it becomes clear that cure is no longer possible. Findings suggest that educating parents about the clinical, emotional, and potential research benefits of autopsy and tissue procurement will ultimately help them make informed decisions and understand the importance of autopsy in medical progress. The future research and clinical implications of these findings are discussed.

  5. 2008 South Carolina Lidar: Marlboro County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  6. 2008 South Carolina Lidar: Chester County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  7. 2012 South Carolina DNR Lidar: Aiken County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Towill Inc. collected LiDAR for over 3,300 square miles in Calhoun, Aiken, Barnwell, Edgefield, McCormick, and Abbeville counties in South Carolina. This metadata...

  8. 2012 South Carolina DNR Lidar: Barnwell County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Towill Inc. collected LiDAR for over 3,300 square miles in Calhoun, Aiken, Barnwell, Edgefield, McCormick, and Abbeville counties in South Carolina. This metadata...

  9. 2012 South Carolina DNR Lidar: Abbeville County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Towill Inc. collected LiDAR for over 3,300 square miles in Calhoun, Aiken, Barnwell, Edgefield, McCormick, and Abbeville counties in South Carolina. This metadata...

  10. 2012 South Carolina DNR Lidar: Edgefield County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Towill Inc. collected LiDAR for over 3,300 square miles in Calhoun, Aiken, Barnwell, Edgefield, McCormick, and Abbeville counties in South Carolina. This metadata...

  11. 2008 South Carolina Lidar: Lancaster County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  12. 2008 South Carolina Lidar: Laurens County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  13. 2008 South Carolina Lidar: Darlington County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  14. 2008 South Carolina Lidar: Orangeburg County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  15. 2008 South Carolina Lidar: Marion County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  16. 2008 South Carolina Lidar: Chesterfield County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  17. 2008 South Carolina Lidar: Williamsburg County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  18. 2008 South Carolina Lidar: Dillon County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  19. 2008 South Carolina Lidar: Greenwood County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  20. 2008 South Carolina Lidar: Fairfield County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  1. 2008 South Carolina Lidar: Newberry County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  2. 2008 South Carolina Lidar: Cherokee County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  3. 2008 South Carolina Lidar: Union County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  4. 2014 Horry County, South Carolina Lidar

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is comprised of lidar point cloud data. This project required lidar data to be acquired over Horry County, South Carolina. The total area of the Horry...

  5. 2011 South Carolina DNR Lidar: York County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Towill Inc. collected LiDAR for over 3,500 square miles in York, Pickens, Anderson, and Oconee Counties in South Carolina. This metadata covers the LiDAR produced...

  6. Libraries in North Carolina: MedlinePlus

    Science.gov (United States)

    ... this page: https://medlineplus.gov/libraries/northcarolina.html Libraries in North Carolina To use the sharing features ... page, please enable JavaScript. Asheville Mountain AHEC (MAHEC) Library and Knowledge Services 121 Hendersonville Rd. Asheville, NC ...

  7. 2012 South Carolina DNR Lidar: Calhoun County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Towill Inc. collected LiDAR for over 3,300 square miles in Calhoun, Aiken, Barnwell, Edgefield, McCormick, and Abbeville counties in South Carolina. This metadata...

  8. 2008 South Carolina Lidar: Clarendon County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  9. Computed tomography (CT) virtual autopsy and classical autopsy discrepancies: radiologist's error or a demonstration of post-mortem multi-detector computed tomography (MDCT) limitation?

    Science.gov (United States)

    Filograna, Laura; Tartaglione, Tommaso; Filograna, Enrica; Cittadini, Francesca; Oliva, Antonio; Pascali, Vincenzo L

    2010-02-25

    Modern imaging technologies, such as computed tomography (CT) techniques, represent a great challenge in forensic pathology. The field of forensics has experienced a rapid increase in the use of these new techniques to support investigations on critical cases, as indicated by the implementation of CT scanning by different forensic institutions worldwide. Advances in CT imaging techniques over the past few decades have finally led some authors to propose that virtual autopsy, a radiological method applied to post-mortem analysis, is a reliable alternative to traditional autopsy, at least in certain cases. The authors investigate the occurrence and the causes of errors and mistakes in diagnostic imaging applied to virtual autopsy. A case of suicide by a gunshot wound was submitted to full-body CT scanning before autopsy. We compared the first examination of sectional images with the autopsy findings and found a preliminary misdiagnosis in detecting a peritoneal lesion by gunshot wound that was due to radiologist's error. Then we discuss a new emerging issue related to the risk of diagnostic failure in virtual autopsy due to radiologist's error that is similar to what occurs in clinical radiology practice. 2009 Elsevier Ireland Ltd. All rights reserved.

  10. Clinical utility and impact of autopsies on clinical practice among doctors in a large teaching hospital in Ghana

    Directory of Open Access Journals (Sweden)

    Edem Tette

    2014-02-01

    : Strengthening the interaction between doctors and pathologists is essential in improving the autopsy process and utilization in the hospital. KBTH should create opportunities for doctors to attend autopsy demonstrations and for pathologists to attend clinicopathological meetings in the hospital.

  11. AGE DETERMINATION FROM PUBIC SYMPHYSEAL CHANGES- AN AUTOPSY STUDY

    Directory of Open Access Journals (Sweden)

    Jinesh Parambathettu Sasidharan

    2017-02-01

    Full Text Available BACKGROUND Biological identity is one of the first things to be established when analysing skeletal, badly decomposed or otherwise unidentified human remains. The determination of age at death is an important component of identity establishment. Pubic symphysis examination is one of the reliable methods of age estimation. We attempt to determine the age of deceased from pubic symphysis using Suchey-Brooks method and to find the accuracy of Suchey-Brooks method in our population. From among the cases brought for autopsy at Department of Forensic Medicine, Government Medical College, Kottayam, Kerala, from 01/03/2012 to 28/02/2013, 316 cases were included in the study. Their pubic symphysis were harvested. Age determined using SucheyBrooks method and compared with their chronological age. The aim of the study is to- 1. Determine the age of deceased from pubic symphysis using Suchey-Brooks method. 2. Compare the age determined by Suchey-Brooks method and chronological age and find the accuracy of Suchey-Brooks method in our population. MATERIALS AND METHODS Study Design- Descriptive study- Cross-sectional study, Centre of Study- Department of Forensic Medicine, Government Medical College, Kottayam, Study Sample- From the cases brought for medicolegal postmortem examination in the Department of Forensic Medicine, Government Medical College, Kottayam, Kerala, a sample of 316 cases were selected. To make the distribution among various age groups, even the total sample divided for the age group, which resulted in having 60 samples per age group. Age groups were considered as Group 1- Age between 18-25 years; Group 2- Age between 25-35 years; Group 3- Age between 35-45 years; Group 4- Age between 45-55 years; Group 5- Age between 55-65 years. Inclusion Criteria- 1. Cases with known age; 2. Cases whose age between 18 and 65 years. Exclusion Criteria- 1. Unknown cases; 2. Known cases with doubtful age; 3. Individuals having pubic bone trauma involving the

  12. Differences between postmortem computed tomography and conventional autopsy in a stabbing murder case

    Directory of Open Access Journals (Sweden)

    Talita Zerbini

    2014-12-01

    Full Text Available Objective: The aim of the present work is to analyze the differences and similarities between the elements of a conventional autopsy and images obtained from postmortem computed tomography in a case of a homicide stab wound. Method: Comparison between the findings of different methods: autopsy and postmortem computed tomography. Results: In some aspects, autopsy is still superior to imaging, especially in relation to external examination and the description of lesion vitality. However, the findings of gas embolism, pneumothorax and pulmonary emphysema and the relationship between the internal path of the instrument of aggression and the entry wound are better demonstrated by postmortem computed tomography. Conclusions: Although multislice computed tomography has greater accuracy than autopsy, we believe that the conventional autopsy method is fundamental for providing evidence in criminal investigations.

  13. Virtual autopsy and forensic anthropology of a mummified fetus: a report of one case.

    Science.gov (United States)

    Dedouit, Fabrice; Guilbeau-Frugier, Céline; Telmon, Norbert; Gainza, David; Otal, Philippe; Joffre, Francis; Rougé, Daniel

    2008-01-01

    A jar containing the mummified body of a fetus was found in a bush near a building. Full-body multislice computed tomography (MSCT) was performed prior to autopsy to study the bones and internal organs. Age was estimated by measuring femoral and tibial lengths and examining the temporal and occipital bones. The results were then compared with the autopsy and histopathological findings. MSCT was superior to autopsy for examination of the bones and internal organs. Autopsy was difficult because of the fragility of the dried corpse. MSCT determined the gestational age of the fetus and excluded skeletal abnormalities. Estimated age was similar with the two methods used. However, the major advantage of MSCT was rapid measurement of bones or anatomical regions which are difficult to examine during autopsy and which required specific preparation for further anthropological study. This case report illustrates the possibilities offered by MSCT for studying mummified bodies, even fetuses.

  14. Forensic autopsy costs in the city of São Paulo

    Directory of Open Access Journals (Sweden)

    Fernando Augusto Mardiros Herbella

    Full Text Available CONTEXT: Modern medical practice involves cost analysis of therapeutic and diagnostic procedures. There are no papers dealing with this theme in relation to forensic autopsies in our country. OBJECTIVE: Analysis of direct costs of forensic autopsies. TYPE OF STUDY: Cost analysis. SETTING: São Paulo Medical Examiner's Central Office. SAMPLE: Year 2001 activity. PROCEDURES: Routine forensic autopsies. MEAN MEASUREMENTS: Analysis of direct costs of personnel and material. RESULTS: Cost of personnel represents 90.38% or US$ 93.46. Material expenses comprised 9.62% or US$ 9.95. Total costs were calculated to be US$ 103.41. CONCLUSIONS: Forensic autopsies have a high cost. Cases to be autopsied should be judiciously selected. Our results are similar to international studies if data are rearranged based on the number of annual necropsies.

  15. How well do we communicate autopsy findings to next of kin?

    Science.gov (United States)

    Keys, Elizabeth; Brownlee, Carolyn; Ruff, Monica; Baxter, Cynthia; Steele, Lisa; Green, Francis H Y

    2008-01-01

    A failure of communication among families, physicians, and pathologists is recognized as a major cause of declining autopsy rates and may be involved in increased litigation. To determine how effectively autopsy results are communicated to the next of kin and how satisfied families are with the process from consent to relaying of the results. A retrospective telephone survey of next of kin of 106 consecutive patients autopsied at a major teaching hospital. The family was asked questions on the process of obtaining consent and the information they received back from health care providers. Thirty-two percent of relatives indicated that they were not adequately informed as to the purpose of the autopsy. Eighty percent of respondents were notified of or obtained the results. The ways in which the autopsy findings were communicated varied, but 54% were involved in a discussion of the results with a medical professional. More than half of the families wished to have a copy of the results. Two-thirds felt they were satisfied with the explanation of the results, but an important cause of dissatisfaction was the use of unfamiliar medical terminology. When the family's understanding of the cause of death was compared with the diagnoses on the autopsy reports, 65% of families demonstrated an accurate knowledge of the autopsy findings, 28% had a general understanding, and for only 8% was their knowledge judged inaccurate. Overall, 92% of notified respondents felt the autopsy had served a useful purpose, mostly for personal reasons. We conclude that the autopsy fulfills an important need for many families; however, the purpose of the autopsy and the findings need to be more effectively communicated.

  16. Forensic medicine experts' opinion on medico-legal autopsies in hospital deaths: a questionnaire survey.

    Science.gov (United States)

    D'Souza, Deepak Herald; Pant, Sadip; Menezes, Ritesh George

    2013-10-01

    Medico-legal autopsy is conducted routinely in some countries and selectively in others in hospital deaths. This study was conducted to evaluate the views of the forensic medicine experts regarding this matter. A questionnaire pro forma was sent to sixty-five forensic medicine experts practicing in different medical institutions all around India. Designations and experiences of the participants were noted by requests in the same questionnaire. Their specific experience in conducting medico-legal autopsy in hospital deaths was also requested for. Responses were charted in frequency distribution tables and analyzed using SPSS, version 17.0. One-third of the participants felt that a medico-legal autopsy was necessary in all the hospital death cases as defined in the present study. Ten percent of the participants opined that a medico-legal autopsy was unnecessary in hospital deaths. The majority of the experts mentioned finding the cause of death, followed by finding the manner of death and collecting the evidentiary materials, as the reasons for medico-legal autopsy in hospital deaths. Twenty percent of the participants felt that internal findings at autopsy poorly matched with the case records. All the experts agreed that external autopsy findings matched with the hospital case records. Nearly two-third of the participants felt that it was difficult in some cases to interpret the autopsy findings without case records from the hospital where the deceased was treated. Our findings suggest that the exercise of carrying out medico-legal autopsy routinely in every hospital death as evident in the Indian framework is often unnecessary as per the experts' opinion. Autopsy findings in hospital deaths often correlate with hospital case records.

  17. Trends in forensic autopsy in Chiba prefecture over the past decade.

    Science.gov (United States)

    Inokuchi, Go; Ishihara, Kenji; Hayakawa, Mutsumi; Yajima, Daisuke; Makino, Yohsuke; Motomura, Ayumi; Chiba, Fumiko; Torimitsu, Suguru; Iwase, Hirotaro

    2014-09-01

    The death investigation system in Japan is in the midst of a great transformation. As part of efforts to revise this system, in this study we analyzed the reasons the police refer unnatural death cases for forensic autopsy and, from an understanding of the trends of such referrals, we discuss the future direction of handling unnatural deaths in our country. For 1618 forensic autopsy cases handled by the First Investigation Division of Chiba Prefectural Police that were referred to our institution for forensic autopsy between 2003 and 2012, we tallied the number of autopsies by sex, age group, and reason for forensic autopsy for each year and investigated trends in the referrals over time. The results revealed that the number of autopsies increased annually from 2003 to 2012, with a marked increase from 2010. The number of autopsies increased particularly for cases of suspected criminal deaths, where it was unclear to the police before the forensic autopsy whether or not the death resulted from a criminal act. Our findings suggest that the number of forensic autopsies will continue to increase into the future in Chiba prefecture, and is a trend that is inevitable if we are to prevent criminal death cases from being overlooked. Although referrals for forensic autopsy in Japan are made only when criminal activity is suspected, the original purpose of death investigations is not only to avoid overlooking crimes, but also to flag public health issues. Therefore, together with the police, we need to review the original purpose and conduct more in-depth discussions about when referrals are necessary. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  18. Cerebellar ataxia in progressive supranuclear palsy: An autopsy study of PSP-C.

    Science.gov (United States)

    Koga, Shunsuke; Josephs, Keith A; Ogaki, Kotaro; Labbé, Catherine; Uitti, Ryan J; Graff-Radford, Neill; van Gerpen, Jay A; Cheshire, William P; Aoki, Naoya; Rademakers, Rosa; Wszolek, Zbigniew K; Ross, Owen A; Dickson, Dennis W

    2016-05-01

    Cerebellar ataxia is an exclusion criterion for the clinical diagnosis of progressive supranuclear palsy, but a variant with predominant cerebellar ataxia has been reported. The aims of this study were to estimate the frequency of progressive supranuclear palsy with predominant cerebellar ataxia in an autopsy series from the United States and to compare clinical, pathologic, and genetic differences between progressive supranuclear palsy with and without predominant cerebellar ataxia. We selected 100 consecutive patients with pathologically confirmed progressive supranuclear palsy who had been evaluated at the Mayo Clinic (referred to as the Mayo Clinic patient series) from our brain bank database (N = 1085). We next enriched in cases likely to have cerebellar ataxia by searching the remaining 985 cases for (1) an antemortem diagnosis of multiple system atrophy or (2) neuropathologic evidence of prominent degeneration of the cerebellum or cerebellar afferent nuclei. Subsequently, clinical, pathologic, and genetic features were compared between the two groups. One patient in the Mayo Clinic patient series (1%) met criteria for progressive supranuclear palsy with predominant cerebellar ataxia and had both cerebellar and mild midbrain atrophy on MRI. Four patients were identified with the targeted search. Four of the five patients were clinically misdiagnosed as multiple system atrophy. The severity of tau-related pathology and cerebellar degeneration were not different between the two groups. No differences were detected in tau genotypes. Although our data cannot provide definitive information about how to make an accurate clinical diagnosis, they should serve to raise awareness of progressive supranuclear palsy with predominant cerebellar ataxia in the differential diagnosis of multiple system atrophy. © 2016 Movement Disorder Society. © 2016 International Parkinson and Movement Disorder Society.

  19. Postmortem noninvasive virtual autopsy: extrapleural hemorrhage after blunt thoracic trauma.

    Science.gov (United States)

    Bolliger, Stephan A; Thali, Michael J; Aghayev, Emin; Jackowski, Christian; Vock, Peter; Dirnhofer, Richard; Christe, Andreas

    2007-03-01

    A 19-year-old man speeding recklessly along a highway caused a left-frontal crash with another car. After his vehicle came to a standstill, he climbed out of the wreck and crawled across the tarmac to the other side of the road, where he died several minutes after the accident and before the arrival of an ambulance. Postmortem multislice computed tomography (MSCT) demonstrated fractures of the first, second, and third ribs and scapula on the left, an extrapleural hemorrhage in the apical region of the left thorax, as well as a large amount of blood in the left thoracic cavity. These radiologic findings were indicative of a delayed rupture of a traumatic extrapleural hematoma into the pleural space. A traditional autopsy confirmed the very rare diagnosis of a traumatic extrapleural hemorrhage with a delayed rupture.

  20. Differences among South Tyrolean suicides: a psychological autopsy study.

    Science.gov (United States)

    Giupponi, Giancarlo; Conca, Andreas; Innamorati, Marco; Forte, Alberto; Lester, David; Erbuto, Denise; Pycha, Roger; Girardi, Paolo; Möller-Leimkühler, Anne Maria; Pompili, Maurizio

    2016-02-01

    The aim of the present study was to study gender differences in the suicides in South Tyrol. Between 2000 and 2009, the Department of Psychiatry of Bolzano administered questionnaires to the Provincial Departments of Public Health requesting information about causes and methods of completed suicides. Each suicide was then examined using a psychological autopsy methodology. There were 448 suicides studied (339 men and 109 women). Compared with men, women were more likely to live alone, have attempted suicide in the past, and to have contacted their general practitioners in the last weeks before dying. They were also less likely to have an alcohol use disorder, have used violent methods of suicide, and be 35 years or younger. The differences identified for South Tyrolean suicides confirmed previously reported gender differences in employment and marital status, history of a previous suicide attempt, and alcohol abuse. Appropriate gender-based preventive interventions are needed.

  1. An autopsy case of vagus nerve stimulation following acupuncture.

    Science.gov (United States)

    Watanabe, Mayumi; Unuma, Kana; Fujii, Yusuke; Noritake, Kanako; Uemura, Koichi

    2015-03-01

    Acupuncture is one of the most popular oriental medical techniques in China, Korea and Japan. This technique is also popular as alternative therapy in the Western World. Serious adverse events are rare following acupuncture, and fatal cases have been rarely reported. A male in his late forties died right after acupuncture treatment. A medico-legal autopsy disclosed severe haemorrhaging around the right vagus nerve in the neck. Other organs and laboratory data showed no significant findings. Thus, it was determined that the man could have died from severe vagal bradycardia and/or arrhythmia resulting from vagus nerve stimulation following acupuncture. To the best of our knowledge, this is the first report of a death due to vagus nerve injury after acupuncture. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  2. Sudden cardiac death and acute drunken state: Autopsy study

    Directory of Open Access Journals (Sweden)

    Miletić Borislav

    2010-01-01

    Full Text Available Introduction. Sudden natural death occurs unexpectedly in apparently healthy subjects, or in persons during an apparent benign phase in the course of disease. The most common cause is sudden cardiac death, which is sometimes the first and last manifestation of coronary heart disease. Alcohol directly influences excitation of myocytes, and therefore provokes arrhythmias and possibly, sudden cardiac death. Objective. To establish the frequency of sudden cardiac death in cases of acute alcohol intoxication, to determine blood alcohol concentration at the moment of death, and to determine frequency and level of ethanol intoxication in chronic alcohol abusers, as well as causes of sudden death in those cases. Method. Retrospective autopsy study was performed for a three-year-period. We analyzed cases of sudden natural death, in relation to age and gender, cause of death, and blood alcohol concentration (at least 0.5 g/L. We considered the person to be a chronic alcoholic abuser if gross examination of organs during autopsy showed changes typical for excessive and habitual alcohol consumption. Results. Our sample consisted of 997 cases: 720 men and 277 women, average age 62.0±15.2 years (min=11; max=98. Total of 753 of them died of sudden cardiac death: much more men (χ2=167.364; p=0.000, significantly younger than women (t=6.203; p=0.000. We determined acute alcohol intoxication in 73 persons - average blood alcohol concentration 1.85±1.01 g/L (min=0.55; max=3.85, and 61 of them died of cardiovascular diseases (χ2=236.781; df=5; p=0.000. Conclusion. In our observed sample, not many persons were under acute alcohol intoxication (around 7%. Most commonly, they were chronic alcohol abusers who died due to exacerbation of chronic heart disease, mildly or moderately intoxicated - the younger, the drunker.

  3. Moral Mondays and the Defense of Public Education: The Fusion Movement against ALEC-Influenced Legislation in North Carolina

    Science.gov (United States)

    Marshall, Catherine; Tichnor-Wagner, Ariel; Johnson, Mark

    2017-01-01

    A barrage of pro-privatization policies that cascaded into North Carolina education statutes during the 2013-2014 legislative session helped spark a series of organized protests known as the Moral Monday Movement. Powerful and strategic policy networks, such as the American Legislative Exchange Council (ALEC), have made privatization and…

  4. Course of major depressive disorder and suicide outcome: a psychological autopsy study.

    Science.gov (United States)

    McGirr, Alexander; Renaud, Johanne; Séguin, Monique; Alda, Martin; Turecki, Gustavo

    2008-06-01

    There is considerable debate as to whether suicide is more likely to occur early in the course of major depressive disorder or by cumulative risk, with an increasing risk with each subsequent major depressive episode (MDE). By considering the number of MDEs among representative suicides, we aimed to further investigate the relationship between suicide outcome and the course of major depressive disorder. A psychological autopsy method with best informants was used to investigate 154 consecutive suicides who died in the context of a DSM-IV MDE. Proxy-based interviews were conducted by using the Structured Clinical Interview for DSM-III-R; the Structured Clinical Interview for DSM-IV Axis II; and a series of behavioral and personality-trait assessments. Second, 143 living depressed outpatients of comparable age to the suicide group were assessed for their history of MDEs. The study was conducted between 2000 and 2005. The distribution of MDEs among depressed suicide completers was as follows: first MDE, 74.7%; second MDE, 18.8%; more than 2 MDEs, 6.5%. This distribution is compared to 32.9% of depressed living outpatients with a single MDE. Increased levels of hostility were associated with single MDE suicide completers. The anxious trait of harm avoidance increased among multiple MDE suicide completers. Alcohol abuse increased among first MDE suicide completers. Suicide in major depressive disorder is most likely to occur during the first MDE, and this appears to be related to increased levels of the impulsive-aggressive diathesis.

  5. Asheville, North Carolina: Reducing Electricity Demand through Building Programs & Policies (City Energy: From Data to Decisions)

    Energy Technology Data Exchange (ETDEWEB)

    Office of Strategic Programs, Strategic Priorities and Impact Analysis Team

    2017-09-29

    This fact sheet "Asheville, North Carolina: Reducing Electricity Demand through Building Programs & Policies" explains how the City of Asheville used data from the U.S. Department of Energy's Cities Leading through Energy Analysis and Planning (Cities-LEAP) and the State and Local Energy Data (SLED) programs to inform its city energy planning. It is one of ten fact sheets in the "City Energy: From Data to Decisions" series.

  6. Rib fractures at postmortem computed tomography (PMCT) validated against the autopsy.

    Science.gov (United States)

    Schulze, Claudia; Hoppe, Hanno; Schweitzer, Wolf; Schwendener, Nicole; Grabherr, Silke; Jackowski, Christian

    2013-12-10

    To evaluate the sensitivity of postmortem computed tomography (PMCT) in rib fracture detection validated against autopsy. Fifty-one forensic cases underwent a postmortem CT prior to forensic autopsy. Two image readers (radiologist and forensic pathologist) assessed high resolution CT data sets for rib fractures. Correct recognition rates (CRR), sensitivity and specificity values were calculated over all observations as well as individually for every rib and region. Additionally, for partial rib fractures the sensitivity of autopsy was calculated vice versa. 3876 entries in each study protocol (autopsy, PMCT radiologist and PMCT forensic pathologist) were investigated. A total of 690 fractures (autopsy), 491 (PMCT and radiologist) and 559 (PMCT and forensic pathologist) were detected. The CRR was 0.85. Sensitivity and specificity of PMCT for rib fracture detection were 0.63 (0.58 radiologist, 0.68 forensic pathologist) and 0.97 (both readers 0.97), respectively. Low CRR and sensitivity values were obtained for antero-lateral fractures. Partial rib fractures were better detected by PMCT. PMCT has a rather low sensitivity for rib fracture detection when validated against autopsy and indicates that clinical CT may also demonstrate a reasonable number of false negatives. Partial rib fractures often remain undetected at autopsy. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  7. Community Knowledge and Perception on Autopsy in Jatinangor, West Java from August to October 2013

    Directory of Open Access Journals (Sweden)

    Siaw Carwen

    2015-09-01

    Full Text Available Background: Autopsy rate had declined dramatically throughout the world for the past decades. This phenomenon has raised concerns of the medical world. Factors that contributed to this decline include lack of knowledge regarding autopsy among the people, religious reasons, unenthusiastic pathologists and others. This study was conducted to discover the community knowledge and perception of autopsy at Jatinangor, West Java. Methods: A descriptive study was conducted in Jatinangor during the period of August to October 2013. One hundred and ten respondents were included in this study by random sampling. After written informed consent, respondents were given a questionnaire. Collected data were presented in the form of percentages in tables. Results: Most of the respondents were from the age group of 41–50, entrepreneur and senior high school. Eighty seven (79.09% respondents had heard about the term “autopsy”, but only 66 (75.86% of them claimed that they knew about autopsy. However, only 53 from 87 respondents (60.92% truly knew about autopsy. From 110 respondents, 58 (52.72% of them knew the reasons to perform autopsy. Fifty seven (51.81% respondents would allow autopsy to be performed on themselves or family members. The main reason was given to discover the exact cause of death. The reasons of autopsy refusal were afraid of religion concerns and respect for the human body. Conclusions: There are still members of the community who do not know about autopsy and its purposes. It is recommended that the government improves the community knowledge through various activities and programs.

  8. Copperhead envenomations in the Carolinas.

    Science.gov (United States)

    Thorson, Alix; Lavonas, Eric J; Rouse, Anna M; Kerns, Wiliam P

    2003-01-01

    Although the copperhead (Akistrodon contortrix) is responsible for most Crotaline envenomations in the Carolinas, manifestations and treatment are poorly characterized. We sought to describe the clinical course after copperhead bites. Structured review of copperhead exposures reported to a regional poison center from 1997-2000. Hospital records were reviewed when available. Phone followup was attempted. A total of 178 cases were identified. Of these 75% were males. The median age was 31 yr (range 2-93). The bite site included hand (52%), foot (36%), leg (7%), and arm (5%). Classification included dry (7%), mild (48%), moderate (39%), and severe (6%). The most common symptom was pain (93%). Local findings included swelling (94%), fang marks (93%), ecchymosis (53%), erythema (37%), bullae (13%), and tissue necrosis (8%). Eleven of 37 patients developed abnormal PT and/or PTT. Two patients bled. Patients were treated at a healthcare facility in 160 cases, with 79 patients admitted. Opioid analgesics were the most common therapy (81%). Equine-derived antivenin was given in 14 cases (range 2-30 vials). Antivenin reactions developed in three. Two patients received blood products. Surgical treatment included debridement (6), grafting (2), digit amputation (1), digit dermotomy (1), and fasciotomy (1). No patients died. In followup, 18 patients reported limb dysfunction ranging from 5-365 days. Copperhead bites typically result in mild to moderate envenomation due to local tissue effects. Significant systemic manifestations are rare. Limb dysfunction can be prolonged.

  9. An autopsy study of combined pulmonary fibrosis and emphysema: correlations among clinical, radiological, and pathological features

    Science.gov (United States)

    2014-01-01

    Background Clinical evaluation to differentiate the characteristic features of pulmonary fibrosis and emphysema is often difficult in patients with combined pulmonary fibrosis and emphysema (CPFE), but diagnosis of pulmonary fibrosis is important for evaluating treatment options and the risk of acute exacerbation of interstitial pneumonia of such patients. As far as we know, it is the first report describing a correlation among clinical, radiological, and whole-lung pathological features in an autopsy cases of CPFE patients. Methods Experts retrospectively reviewed the clinical charts and examined chest computed tomography (CT) images and pathological findings of an autopsy series of 22 CPFE patients, and compared these with findings from 8 idiopathic pulmonary fibrosis (IPF) patients and 17 emphysema-alone patients. Results All patients had a history of heavy smoking. Forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC%) was significantly lower in the emphysema-alone group than the CPFE and IPF-alone groups. The percent predicted diffusing capacity of the lung for carbon monoxide (DLCO%) was significantly lower in the CPFE group than the IPF- and emphysema-alone groups. Usual interstitial pneumonia (UIP) pattern was observed radiologically in 15 (68.2%) CPFE and 8 (100%) IPF-alone patients and was pathologically observed in all patients from both groups. Pathologically thick-cystic lesions involving one or more acini with dense wall fibrosis and occasional fibroblastic foci surrounded by honeycombing and normal alveoli were confirmed by post-mortem observation as thick-walled cystic lesions (TWCLs). Emphysematous destruction and enlargement of membranous and respiratory bronchioles with fibrosis were observed in the TWCLs. The cystic lesions were always larger than the cysts of honeycombing. The prevalence of both radiological and pathological TWCLs was 72.7% among CPFE patients, but no such lesions were observed in patients with IPF or emphysema

  10. DIGITAL FLOOD INSURANCE RATE MAP DATABASE, Scotland County, North Carolina

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — This Flood Insurance Study was produced through a cooperative partnership between the State of North Carolina and FEMA. The North Carolina Floodplain Mapping...

  11. North Carolina Statewide Lidar DEM 2015 Phase 3

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Geographic Extent: North Carolina Area of Interest, covering approximately 7,197 square miles. Dataset Description: The North Carolina LiDAR project called for the...

  12. 2015 NCFMP Lidar: Statewide North Carolina (Phase 3)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Geographic Extent: North Carolina Area of Interest, covering approximately 7,197 square miles. Dataset Description: The North Carolina LiDAR project called for the...

  13. DIGITAL FLOOD INSURANCE RATE MAP DATABASE, GREENE COUNTY, NORTH CAROLINA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — This Flood Insurance Study was produced through a cooperative partnership between the State of North Carolina and FEMA. The North Carolina Floodplain Mapping...

  14. DIGITAL FLOOD INSURANCE RATE MAP DATABASE, LENOIR COUNTY, NORTH CAROLINA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — This Flood Insurance Study was produced through a cooperative partnership between the State of North Carolina and FEMA. The North Carolina Floodplain Mapping...

  15. DIGITAL FLOOD INSURANCE RATE MAP DATABASE, WILSON COUNTY, NORTH CAROLINA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — This Flood Insurance Study was produced through a cooperative partnership between the State of North Carolina and FEMA. The North Carolina Floodplain Mapping...

  16. DIGITAL FLOOD INSURANCE RATE MAP DATABASE, HALIFAX COUNTY, NORTH CAROLINA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — This Flood Insurance Study was produced through a cooperative partnership between the State of North Carolina and FEMA. The North Carolina Floodplain Mapping...

  17. North Carolina Statewide Lidar DEM 2014 Phase 1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Geographic Extent: North Carolina Area of Interest for Sandy, covering approximately 9,396 square miles. Dataset Description: The North Carolina - Sandy LiDAR...

  18. 2014 NCFMP Lidar: Statewide North Carolina (Phase 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Geographic Extent: North Carolina Area of Interest for Sandy, covering approximately 9,396 square miles. Dataset Description: The North Carolina - Sandy LiDAR...

  19. F-15E Beddown at Seymour Johnson AFB, North Carolina

    Science.gov (United States)

    1988-03-01

    forficatus) "* Carolina lilaeopsis ( Lilaeopsis carolinensis) "* Sensitive joint-vetch (Aeschvnomene virainica) "* Pine barrens treefrog (Hyla andersonii...tomentos) SRS Carolina Lilaeopsis ( Lilaeopsis carolinensis T (=L. attenuata)) Southern Twayblade (Listera australis) SRS Winged Seedbox (Ludwigia alata

  20. The Breakfast Club: case study of a teaching-autopsy curriculum.

    Science.gov (United States)

    O'grady, Gregory

    2004-06-01

    A decision prohibiting student access to coronial autopsies in Auckland, New Zealand, was recently discussed in the British Medical Journal (O'Grady, ). Clinical and ethical implications aside, the prohibition brought an end to the Breakfast Club, a remarkable community of post-mortem learning. Over 20 years of voluntary attendance at autopsy, this group of students established a self-directed curriculum based around daily encounters at the post-mortem table. The success of the group testifies to the ongoing value of the autopsy as a medical teaching medium in the current era.

  1. Utility of Postmortem Autopsy via Whole-Body Imaging: Initial Observations Comparing MDCT and 3.0T MRI Findings with Autopsy Findings

    Science.gov (United States)

    Cha, Jang Gyu; Kim, Dong Hun; Kim, Dae Ho; Paik, Sang Hyun; Park, Jai Soung; Park, Seong Jin; Lee, Hae Kyung; Hong, Hyun Sook; Choi, Duek Lin; Chung, Nak Eun; Lee, Bong Woo; Seo, Joong Seok

    2010-01-01

    Objective We prospectively compared whole-body multidetector computed tomography (MDCT) and 3.0T magnetic resonance (MR) images with autopsy findings. Materials and Methods Five cadavers were subjected to whole-body, 16-channel MDCT and 3.0T MR imaging within two hours before an autopsy. A radiologist classified the MDCT and 3.0T MRI findings into major and minor findings, which were compared with autopsy findings. Results Most of the imaging findings, pertaining to head and neck, heart and vascular, chest, abdomen, spine, and musculoskeletal lesions, corresponded to autopsy findings. The causes of death that were determined on the bases of MDCT and 3.0T MRI findings were consistent with the autopsy findings in four of five cases. CT was useful in diagnosing fatal hemorrhage and pneumothorax, as well as determining the shapes and characteristics of the fractures and the direction of external force. MRI was effective in evaluating and tracing the route of a metallic object, soft tissue lesions, chronicity of hemorrhage, and bone bruises. Conclusion A postmortem MDCT combined with MRI is a potentially powerful tool, providing noninvasive and objective measurements for forensic investigations. PMID:20592923

  2. Utility of Postmortem Autopsy via Whole-Body Imaging: Initial Observations Comparing MDCT and 3.0T MRI Findings with Autopsy Findings

    Energy Technology Data Exchange (ETDEWEB)

    Cha, Jang Gyu; Kim, Dong Hun; Paik, Sang Hyun [National Institute of Scientific Investigation, Seoul (Korea, Republic of)

    2010-08-15

    We prospectively compared whole-body multidetector computed tomography (MDCT) and 3.0T magnetic resonance (MR) images with autopsy findings. Five cadavers were subjected to whole-body, 16- channel MDCT and 3.0T MR imaging within two hours before an autopsy. A radiologist classified the MDCT and 3.0T MRI findings into major and minor findings, which were compared with autopsy findings. Most of the imaging findings, pertaining to head and neck, heart and vascular, chest, abdomen, spine, and musculoskeletal lesions, corresponded to autopsy findings. The causes of death that were determined on the bases of MDCT and 3.0T MRI findings were consistent with the autopsy findings in four of five cases. CT was useful in diagnosing fatal hemorrhage and pneumothorax, as well as determining the shapes and characteristics of the fractures and the direction of external force. MRI was effective in evaluating and tracing the route of a metallic object, soft tissue lesions, chronicity of hemorrhage, and bone bruises. A postmortem MDCT combined with MRI is a potentially powerful tool, providing noninvasive and objective measurements for forensic investigations

  3. Importance of explanation before and after forensic autopsy to the bereaved family: lessons from a questionnaire study.

    Science.gov (United States)

    Ito, Takako; Nobutomo, Koichi; Fujimiya, Tatsuya; Yoshida, Ken-ichi

    2010-02-01

    To investigate how bereaved families felt about the explanation received before and after forensic autopsies, the authors conducted a cross-sectional survey of the bereaved families whose next of kin underwent a forensic autopsy at the two Departments of Forensic Medicine and a few bereaved families of crime victims. Of 403 questionnaires sent, 126 families responded. Among 81.5% of the respondents who received an explanation from policemen before the autopsy, 78.8% felt that the quality of the explanation was poor or improper. In Japan, the law has restricted disclosure of information from a forensic autopsy. Despite legal restrictions, 82% wanted to hear from the person who conducted the autopsy. However, police explained the results of autopsy to 65.2% of respondents. Among the families whose frustration and anger increased after autopsy, 86.4% had not been satisfied with the explanation before the autopsy. Additionally, 57.7% had not been informed on the autopsy findings at the time of the questionnaire when more than 2 years had passed after the autopsy. These results reminded us of the importance of an explanation before and shortly after a forensic autopsy for a better understanding and acceptance by bereaved families.

  4. Infinite series

    CERN Document Server

    Hirschman, Isidore Isaac

    2014-01-01

    This text for advanced undergraduate and graduate students presents a rigorous approach that also emphasizes applications. Encompassing more than the usual amount of material on the problems of computation with series, the treatment offers many applications, including those related to the theory of special functions. Numerous problems appear throughout the book.The first chapter introduces the elementary theory of infinite series, followed by a relatively complete exposition of the basic properties of Taylor series and Fourier series. Additional subjects include series of functions and the app

  5. SUDDEN NATURAL DEATHS IN MEDICOLEGAL CASES- AN AUTOPSY BASED STUDY

    Directory of Open Access Journals (Sweden)

    C. S. Sreedevi

    2017-01-01

    Full Text Available BACKGROUND Death occurring in apparently healthy individual in a case of natural death may arise suspicion of foul play. In these circumstances these cases may be subjected to medicolegal autopsy. The disease condition may be unknown to the individual and the relatives. This study was done to review the exact cause of death in sudden unexpected deaths, and enabling or assisting the legal authorities in detection of crime, to prove or disprove the foul play. Body mass index is the most frequently used indicator of body fatness. An attempt is made to find out whether there is any significant relationship between BMI and the risk for sudden cardiac death. MATERIALS AND METHODS Data of 50 cases of sudden unexpected death brought for medicolegal autopsy at govt. T.D. medical college Alappuzha in the year 2010 were studied and information were collected from the postmortem records. Data was entered in the proforma. The histopathological examination findings of relevant cases were studied. Analysis was done using MS EXCEL and Chi-square test was used as the test of significance in the comparison between two categorical variables. RESULTS In 50 cases, male predominance was observed and 88% were males in which 50% of males died of atherosclerotic occlusive coronary artery disease and among females 33% died of myocardial infarction. While considering the systemic distribution of cause of death, the cardiovascular system was found to be most commonly affected, 33 cases (66% followed by respiratory system 7 cases (14%. In 4 (8% cases gastrointestinal system was affected. In Two cases (4% central nervous system was affected and others were generalized infection, which constituted 2 cases. Out of 33 cases observed in cardiovascular system the commonest cause being the atherosclerotic occlusive coronary artery diseases involving 27 cases (81.81% in which the predominant involvement was seen in left anterior descending artery 21 cases (77.77% followed by right

  6. Autopsy following death by homicide in 644 cases.

    Science.gov (United States)

    Soumah, Mohamed Maniboliot; Munyali, Désiré Aluméti; Ndiaye, Mor; Sow, Mamadou Lamine

    2012-02-01

    The objectives of this study are to determine the cause of death and based on the wounds, to analyze the different epidemiological variables on homicide in Dakar. Included were all homicides cases where an autopsy was performed and these results recorded in the autopsy register. The data collected in our work included, identity, sex, age, place of crime (location), the cause of death (the causative agent and the anatomical region injured) and the mechanism of death (the pathophysiological phenomenon causing death). On average 56 cases of homicide a year are reported, ranging from 44 cases in 2005 to 80 cases in 1999. Extrapolated to the population of Dakar this corresponds to 1.9 homicides per 100,000 inhabitants. Victims aged over 55 years represented only 4.03% of all victims. 6.52% of cases were infanticide. The crimes mainly took place in the suburbs of Dakar (51.42% of cases). Hand held weapons were used in 578 cases (89.7%) followed by firearms in 44 cases (6.8%). The study of the age of the victims has some interesting points. The homicide of elderly people in Senegal was relatively low in contrast to what is found in a developed country. The youthfulness of our population also explains the large number of homicide victims between 21 and 25. Infanticide is a particular problem in Senegal. In our study, 50.6% of homicides were found in the suburbs of Dakar followed by the peripheral area which accounted for 29.3% of homicides. The incidence of homicide can be directly correlated with the level of economic development. This frequency is much higher where incomes are low and particularly affect young males. The study of this phenomenon should lead to better prevention. The victim-type in Dakar is a young man, aged 20-25 years, killed by an instrument with an injury to the skull, neck, heart or main arteries, causing bleeding and death. Copyright © 2011 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  7. An autopsy study of 74 cases of cut throat injuries

    Directory of Open Access Journals (Sweden)

    Dinesh Rao

    2015-12-01

    Full Text Available The present prospective autopsy study was carried out during the period July 2009 to May 2012 in Kingston, Jamaica. A total of 74 cases of cut throat injury were studied. All the cut throat injuries irrespective of those directly or indirectly contributing to the death were studied. Males dominated the list of victims, contributing to 71.62% (n = 53. Majority of those were in the age group 21–30 (n = 25 and 31–40 (n = 26 which contributed to 33.78% and 35.13% respectively. Majority of the cases were homicides contributing to 97.29% (n = 72 of cases, only 2.7% were suicides and accidental cut throat were never reported. Males dominated the homicides category contributing to 72.22% (n = 52 of the cases. Gang and relationship crisis (homosexual and heterosexual were the major motivating factors, each contributing to 39.19% (n = 29 and 32.43% (n = 24 of the cases, respectively. The disease suffered by individuals were the least motivating factors contributing to 1.35% of cases (n = 01. The most common cause of death was exsanguinations in 49.95% (n = 34 of cases followed closely by asphyxia due to aspiration of blood i.e. 36.49% (n = 27 of cases and air embolism was the least cause of death, contributing to 4.05% (n = 03 of cases. Cut throat injury was associated with other injuries like gunshot wound, chop wounds and stab wounds in 13.52% of (n = 10 autopsies. Chop injuries contributed to maximum number of other injuries in homicides (n = 46. The most preferred place for the crime was an open field or farm (n = 26. Majority of the cut throat wounds were situated in zone II level contributing to 66.21% (n = 49 of cases. Majority of the wounds were directed from left to right in 75.68% (n = 56 of cases and the cervical vertebra was affected in 8.11% (n = 06 of cases. Major weapon of choice was machete contributing to 83.78% (n = 62 of injuries. The low income group was the most affected group contributing to 91

  8. Sudden death after chest pain: feasibility of virtual autopsy with postmortem CT angiography and biopsy

    National Research Council Canada - National Science Library

    Ross, Steffen G; Thali, Michael J; Bolliger, Stephan; Germerott, Tanja; Ruder, Thomas D; Flach, Patricia M

    2012-01-01

    ...) angiography combined with image-guided tissue biopsy of the myocardium and lungs in decedents who were thought to have died of acute chest disease and to compare this method with conventional autopsy...

  9. A bite into the history of the autopsy : From ancient roots to modern decay.

    Science.gov (United States)

    Burton, Julian L

    2005-12-01

    The autopsy has had a checkered history, much of which has been surrounded by controversy. The roots of human dissection are found in the ancient world where rumors flourished that the prosectors of the day were engaged in vivisection as well as dissection. Bound up with the prevailing religious and political systems of the day, the autopsy has alternately been prohibited and encouraged, used to explore the nature of disease, and conceal questionable political policy. This review explores the history of the autopsy from its ancient roots in Egypt, Mesopotamia, Alexandria, and the Far East through the dark ages to medieval times and beyond into the renaissance. The development of the autopsy in Europe during the 17th to 19th centuries is discussed before briefly considering the decline of this diagnostic tool in the 20th century.

  10. Psychosocial and psychiatric risk factors for suicide: Case--control psychological autopsy study

    National Research Council Canada - National Science Library

    CHENG, ANDREW T. A; CHEN, TONY H. H; CHEN, CHWEN-CHEN; JENKINS, RACHEL

    2000-01-01

    .... To do so in a representative sample of suicides. A case-control psychological autopsy was conducted among 113 consecutive suicides and 226 living controls matched for age, gender, ethnicity and area of residence in Taiwan...

  11. Mental Disorders and Suicide Among Young Rural Chinese: A Case-Control Psychological Autopsy Study

    National Research Council Canada - National Science Library

    Zhang, Jie; Xiao, Shuiyuan; Zhou, Liang

    2010-01-01

    .... MethodIn this case-control psychological autopsy study, face-to-face interviews were conducted to collect information from proxy informants for 392 suicide victims and 416 living comparison subjects...

  12. Analysis of Forensic Autopsy in 120 Cases of Medical Disputes Among Different Levels of Institutional Settings.

    Science.gov (United States)

    Yu, Lin-Sheng; Ye, Guang-Hua; Fan, Yan-Yan; Li, Xing-Biao; Feng, Xiang-Ping; Han, Jun-Ge; Lin, Ke-Zhi; Deng, Miao-Wu; Li, Feng

    2015-09-01

    Despite advances in medical science, the causes of death can sometimes only be determined by pathologists after a complete autopsy. Few studies have investigated the importance of forensic autopsy in medically disputed cases among different levels of institutional settings. Our study aimed to analyze forensic autopsy in 120 cases of medical disputes among five levels of institutional settings between 2001 and 2012 in Wenzhou, China. The results showed an overall concordance rate of 55%. Of the 39% of clinically missed diagnosis, cardiovascular pathology comprises 55.32%, while respiratory pathology accounts for the remaining 44. 68%. Factors that increase the likelihood of missed diagnoses were private clinics, community settings, and county hospitals. These results support that autopsy remains an important tool in establishing causes of death in medically disputed case, which may directly determine or exclude the fault of medical care and therefore in helping in resolving these cases. © 2015 American Academy of Forensic Sciences.

  13. The forensic autopsy as a teaching tool: Attitudes and perceptions of ...

    African Journals Online (AJOL)

    The strengths, weaknesses, opportunities and threats (SWOT) analysis indicated the following as strengths: record keeping, legislation review and traumatology description; as weaknesses: emotional trauma and nightmares; as opportunities: the attendance of autopsies; and as threats: physical dangers. Conclusion.

  14. Minimally invasive fetal autopsy using three-dimensional ultrasound: a feasibility study.

    Science.gov (United States)

    Votino, C; Bessieres, B; Segers, V; Kadhim, H; Razavi, F; Condorelli, M; Votino, R; D'Ambrosio, V; Cos T, T

    2014-08-05

    We aim to evaluate a new technique for minimally invasive autopsy: the Post-Mortem Ultrasound (PM-US). Our purpose is to demonstrate its feasibility and sensitivity in detecting major congenital abnormalities as compared to conventional autopsy. We recruited 88 consecutive foetuses, from 11 to 40 weeks gestation (WG), coming from TOP, miscarriages and IUFD in a referral hospital over a 19 months period study. We performed a post-mortem ultrasound using different transducers and data were compared with conventional autopsy. Conventional autopsy was performed according to the Societé Francaise de Foetopathologie (SOFFET, France) guidelines, conducted by experienced perinatal pathologists, blinded to the ultrasound data. The ultrasound and autopsy data were recorded in the same database. a complete virtual autopsy by ultrasound was possible in 95% of the cases. Sensitivity in detecting brain abnormalities was 91% (95% CI, 89,4-93,8%), with a specificity of 90% (95% CI, 83,7-97,6%). In 20% of cases, a neuropathological examination was not possible due to extreme maceration. The sensitivity of PM-US in detecting thoracic abnormalities was 88% (95% CI, 82,2-95,3%) and the specificity was 92% (95% CI, 86,3-97,6%). Concerning abdominal anomalies, we also found a sensitivity of 87% (95% CI, 79,9-94%) and a specificity of 95% (95% CI, 90,4-99,5%). This pilot study confirms the feasibility of PM-US for a virtual autopsy as early as 11 weeks gestation. This new technique shows a high sensitivity and specificity in detecting congenital structural abnormalities as compared to conventional autopsy. This article is protected by copyright. All rights reserved.

  15. [Virtual autopsy (virtopsy) in forensic science: from the scalpel to the scanner].

    Science.gov (United States)

    Thali, M

    2011-11-01

    The aim of "virtopsy" is to utilize modern imaging technology to optimize classical autopsy documentation. The benefits of virtopsy include examiner-independent, objective 3D documentation and its non-invasive approach. Virtopsy is an option in cases where autopsy is rejected by family members or for religious reasons. It is also suitable as a rapid identification and examination tool in large-scale disasters. Forensic findings can be presented to prosecutors and courts in 3D and without bloody images.

  16. Brain biochemistry in autopsied patients with essential tremor.

    Science.gov (United States)

    Shill, Holly A; Adler, Charles H; Beach, Thomas G; Lue, Lih-Fen; Caviness, John N; Sabbagh, Marwan N; Sue, Lucia I; Walker, Douglas G

    2012-01-01

    The pathology of essential tremor is increasingly being studied; however, there are limited studies of biochemical changes in this condition. We studied several candidate biochemical/anatomical systems in the brain stem, striatum, and cerebellum of 23 essential tremor subjects who came to autopsy, comparing them with a control population. Striatal tyrosine hydroxylase, a marker of dopaminergic neurons, was 91.7 ± 113.2 versus 96.4 ± 102.7 ng/mg (not significant) in cases and controls, respectively. Locus coeruleus dopamine beta-hydroxylase, a marker of noradrenergic neurons, was not significantly different between the essential tremor and control groups. Parvalbumin, a marker of GABAergic neurons, was 199.3 ± 42.0 versus 251.4 ± 74.8 ng/mg (P = .025) in the pons in the region of the locus coeruleus of essential tremor subjects versus controls, whereas there was no difference in cerebellar parvalbumin. These results are supportive of a possible role for reduced GABAergic function in the locus coeruleus in essential tremor. The hypothesis that essential tremor represents early Parkinson's disease was not supported, as striatal dopaminergic markers were not reduced compared with control subjects. Copyright © 2011 Movement Disorder Society.

  17. Beethoven's autopsy revisited: A pathologist sounds a final note.

    Science.gov (United States)

    Oiseth, Stanley J

    2017-08-01

    This review of the original autopsy report of Beethoven's remains indicates Paget's disease within the skull, which was dense and twice normal thickness, with dilated vessels at the petrous bone. The facial nerves were enlarged and the eighth nerves atrophied despite their sharing a common meatus at the internal auditory canal. Nephrolithiasis and pyelonephritis with cortical and perinephric abscesses were also reported. The hypercalcaemia was probably caused by hyperparathyroidism, which may be associated with Paget's disease, and both may have played a role in his psychiatric symptoms as well as in his abdominal pain and gastrointestinal complaints. Since Paget's disease may also be associated with gout, some of the joint pains could be attributable to this as well. Hypovitaminosis A from chronic pancreatitis is suggested as a cause of painful eyes and either quinine abuse or severe hypercalcaemia as a cause of arrhythmias. Beethoven died of terminal cirrhosis with chronic pancreatitis, most likely related to chronic excessive intake of alcohol. Thus, Paget's disease, complicated by hyperparathyroidism, gout, and attempts to find relief of symptoms through the use of alcohol, quinine, and possibly salicylates can explain virtually all of Beethoven's medical problems, some of which appear to have influenced his musical compositions.

  18. Deaths from abdominal trauma: analysis of 1888 forensic autopsies

    Directory of Open Access Journals (Sweden)

    POLYANNA HELENA COELHO BORDONI

    Full Text Available ABSTRACT Objective: to evaluate the epidemiological profile of deaths due to abdominal trauma at the Forensic Medicine Institute of Belo Horizonte, MG - Brazil. Methods: we conducted a retrospective study of the reports of deaths due to abdominal trauma autopsied from 2006 to 2011. Results: we analyzed 1.888 necropsy reports related to abdominal trauma. Penetrating trauma was more common than blunt one and gunshot wounds were more prevalent than stab wounds. Most of the individuals were male, brown-skinned, single and occupationally active. The median age was 34 years. The abdominal organs most injured in the penetrating trauma were the liver and the intestines, and in blunt trauma, the liver and the spleen. Homicide was the most prevalent circumstance of death, followed by traffic accidents, and almost half of the cases were referred to the Forensic Medicine Institute by a health unit. The blood alcohol test was positive in a third of the necropsies where it was performed. Cocaine and marijuana were the most commonly found substances in toxicology studies. Conclusion: in this sample. there was a predominance of penetrating abdominal trauma in young, brown and single men, the liver being the most injured organ.

  19. Cardiac involvement in Wegener granulomatosis diagnosed at autopsy.

    Science.gov (United States)

    Mukhopadhyay, Sanjay; Hensley, Richard G; Tazelaar, Henry D

    2010-01-01

    Wegener granulomatosis (WG) is a systemic vasculitis classically involving the lungs, kidneys, and upper respiratory tract. Involvement of other sites does occur but is less frequent. Clinically evident cardiac involvement is uncommon. There are only a few cases in the literature with documentation of the histologic appearance of cardiac involvement in WG. We report a case of a previously healthy 37-year-old man who presented with a one-week history of cough and weakness and a one-day history of shortness of breath. At presentation, he was hypoxic and required intubation. Upon hospitalization, he deteriorated rapidly, became bradycardic and expired the same night. Infection was suspected clinically as the cause of illness and death. At autopsy, the lungs showed diffuse alveolar hemorrhage with capillaritis, diffuse alveolar damage, and parenchymal necrosis with necrotizing granulomas. The heart was enlarged and showed a mixed inflammatory infiltrate composed of neutrophils, eosinophils, and histiocytes, with focal myocyte necrosis. Granulomas, giant cells, and vasculitis were absent. The esophagus showed submucosal vasculitis. A diagnosis of WG was made. Postmortem serology for c-ANCA was positive, and all cultures were negative, confirming the diagnosis. Cardiac involvement is an underrecognized and potentially fatal complication of WG. The histologic findings in the heart may consist of a non-specific inflammatory infiltrate without granulomas or vasculitis, raising a wide differential diagnosis. Copyright 2010 Elsevier Inc. All rights reserved.

  20. Hypertrophic cardiomyopathy: an autopsy analysis of 14 cases.

    Directory of Open Access Journals (Sweden)

    Phadke R

    2001-07-01

    Full Text Available BACKGROUND: Hypertrophic cardiomyopathy (HCM is one of the less common forms of primary cardiomyopathies. There is little data available on HCM in Indian literature. AIMS: To assess the incidence and analyse the clinicopathological features of HCM. SETTINGS: Analysis of data of 15 years from a tertiary care centre. METHODS AND MATERIAL: The clinical and pathological data in fourteen cases of HCM with respect to their gross and microscopic features and clinical presentation were reviewed. RESULTS: Incidence of HCM amongst the autopsied primary cardiomyopathies (N = 101 was 13.9% (n=14. Males were affected more. Common presenting symptoms were exertional dyspnoea, angina and palpitations. Concentric and asymmetric hypertrophy was equally seen. Obliterative small vessel disease was noted in 50% of the cases. Although significant myofibre disarray (>5% was seen in all fourteen cases, it could be demonstrated in only 40- 50% of an average of twenty sections studied. Type IA myofibre disarray was the commonest. Six of the fourteen patients died suddenly. Cardiac failure was the commonest cause of death. CONCLUSIONS: Myofibre disarray is a highly sensitive and specific marker for HCM only when considered in a quantitative rather than a qualitative fashion. In this context, the rationale for performing endomyocardial biopsy is to rule out mimics of HCM.

  1. The Significance of Subendocardial Hemorrhages Detected in Forensic Autopsies

    Directory of Open Access Journals (Sweden)

    Nursel Türkmen İnanır

    2015-06-01

    Full Text Available Introduction:In our study, our aim was to reveal the relationship between subendocardial hemorrhage (SEH  which can be seen macroscopically immediately beneath the endocardium, and emerge secondary to many conditions from direct cardiac,  head, and abdominal traumas to hyperemia, and its location with cause of death, its diagnostic value (if any, and whether it can be evaluated as a vital finding.Material and Method :285 autopsy cases diagnosed as SEH which were brought to the Group Presidency of Morgue Specialization Department of the State Institute of Forensic Medicine of Bursa  were included in the studyResults: Study population consisted of 229 (80.4 % male, and 56 (19.6 % female patients. Thity-one cases of death were related to natural causes, while the most frequently detected pathological causes of death were isolated abdominal traumas (32.9 %, followed by isolated head traumas (31.9 %.  While traffic accidents ranked first (35.1% among the events leading to death. Among evaluated cases, SEH was mostly located on septum.Discussion: To fully understand the yet inadequately elucidated pathogenic mechanisms  of SEH , it should be accurately defined by histopathological analysis. Even though various causes of death seen  in association with these lesions suggest more than one underlying pathogenic mechanism, because of their nonspecific characteristics, their possible roles as indicators of vitality (if any should be reinforced  by further studies.

  2. Brain calcification in hypoxic-ischemic lesions: an autopsy review.

    Science.gov (United States)

    Ansari, M Q; Chincanchan, C A; Armstrong, D L

    1990-01-01

    Calcification of ischemic lesions in a child's brain is well recognized by pathologists; however, clinicians and radiologists usually associate cerebral calcification with infections, particularly the TORCH organisms. We illustrate this phenomenon in a 5-month-old infant with extensive, calcified, multicystic encephalomalacia without evidence of a cerebral infection. In order to ascertain the incidence of cerebral calcification in pure hypoxic-ischemic lesions, we retrospectively analyzed 486 consecutive autopsies. Ninety-nine patients had histologic evidence of cerebral hypoxic-ischemic lesions and hypoxia or ischemia. Thirty-nine of these patients displayed microscopic calcification; 23 patients had slight, 12 had minor, and 4 had prominent calcifications. Prominent calcification lesions were large enough to be detected by routine radiologic methods. Correlations between degree of calcification and the underlying disease process and between the gestational age and the length of survival were not statistically significant. This study illustrates the very frequent occurrence of brain calcification in ischemic brain lesions in children. It is necessary to include this diagnosis in the differential diagnosis of cerebral calcification.

  3. An autopsy case of methanol induced intracranial hemorrhage.

    Science.gov (United States)

    Kim, Hye-Jeong; Na, Joo-Young; Lee, Young-Jik; Park, Jong-Tae; Kim, Hyung-Seok

    2015-01-01

    The major component of car washer fluid is a methanol. Intracranial hemorrhage is a rare but lethal complication in methanol poisoning. We report a case of massive bilateral basal ganglia hematoma in a 32-year-old man with methanol poisoning. He drank car washer solution twice time (about 500 ml), and was admitted to a territorial hospital 10 hours post-ingestion for depressed mental status, lower blood pressure, and high anion gap metabolic acidosis. Computed tomographic (CT) scan showed lesions in both putamen and cerebral deep white matter. Twenty-one days after methanol exposure, he suddenly developed cardiorespiratory arrest. In autopsy, external examination revealed moderate cerebral edema, but no evidence of herniation. Coronal sections of the brain showed softening and about 34 g hematoma in the bilateral putamen and 3rd ventricles. The toxic effect of methanol on the visual system has been noted in the absence of neurologic manifestations; however, there have also been a report of concomitant brain in Korea.

  4. Implications of alcoholic cirrhosis in atherosclerosis of autopsied patients

    Directory of Open Access Journals (Sweden)

    Luciano Alves Matias da Silveira

    Full Text Available Summary Introduction: Alcoholism is a major public health problem, which has a high social cost and affects many aspects of human activity. Liver disease is one of the first consequences of alcohol abuse, and steatosis, liver cirrhosis and hepatitis may occur. Other organs are also affected with pathological changes, such as pancreatitis, cardiomyopathies, dyslipidemias and atherosclerosis. Objective: To identify the occurrence and degree of atherosclerosis in alcohol-dependent individuals with liver cirrhosis, observing macroscopic and microscopic changes in lipid and collagen deposits and in the liver. We also aimed to verify the association of lipid and collagen fiber deposits with gender, age and body mass index, and to relate alcoholism, liver cirrhosis and atherosclerosis. Method: We performed a study based on autopsy reports of patients with alcoholic liver cirrhosis, with analysis of aorta and liver fragments to verify the occurrence and degree of atherosclerosis, as well as collagen contents. Results: Microscopic atherosclerosis was higher in young subjects (early injury and in patients with alcoholic liver cirrhosis. The macroscopic analysis of atherosclerosis in aortas showed that patients in more advanced age groups presented more severe classifications. Atherosclerosis, both micro and macroscopically, and the percentage of fibrosis in the liver and aorta were more expressive in females. Conclusion: Cirrhotic patients presented a higher percentage of fibrosis and lipidosis, and may represent a group susceptible to the accelerated progression of cardiovascular diseases. Investigative studies contribute to targeting health-promoting interventions, reducing the mortality and costs of treating cardiovascular disease.

  5. Sudden Suspected Death in Emergency Department: Autopsy Results

    Directory of Open Access Journals (Sweden)

    Mehtap GURGER

    2014-09-01

    Full Text Available SUMMARY: Objectives: Sudden deaths occur within 24 hours after symptoms' onset and are caused by cardiac, neurological and pulmonary diseases. Autopsy is the gold standard in determining cause of death. In this study, death's etiology was evaluated in cases applied to our department that underwent autopsy with sudden death indication. Methods: This study included cases aged 18 or older with sudden, suspected, non-traumatic death applying to our department between 2008 and 2012. Patients' age, sex, death time, co-morbid diseases, initial signs, cardiac rhythm, and autopsy findings were recorded after reviewing patient charts. Results: The study included 46 patients. Mean age was 45.73±19.6. Of the cases, 84.78% applied to emergency with cardiopulmonary arrest. Thirty-two cases (69.6% were male. The most frequent cause of death was cardiovascular diseases (52.2%, followed by central nervous system disorders (21.7%, intoxications (15.2%, and respiratory diseases (10.9%. The most common diseases were myocardial infarction (45.7%, subarachnoid hemorrhage (8.7%, and chronic obstructive pulmonary disease. There were three drug ingestions, three carbon monoxide intoxications, and one corrosive material ingestion among the intoxication cases. Conclusions: Sudden deaths are rarely encountered. Emergency clinicians should consider cause in differential diagnosis and provide appropriate approaches at first evaluation. ÖZET: Amaç: Ani ölümler semptomlar başladıktan sonra 24 saat içerisinde oluşur. En yaygın nedenleri kardiyak, nörolojik ve pulmoner hastalıkları içerir. Otopsi bu ölümlerin nedenini tespit etmede altın standarttır. Bu çalışmada acil servisimize başvuran ani ölüm olgularının otopsi bulgularına göre ölüm nedenlerini değerlendirdik. Gereç ve Yöntem: Bu retrospektif çalışmaya 2008–2012 yılları arasında acil servisimize başvuran, yaşları 18 ve üzeri olan, nontravmatik, ani, şüpheli ölüm vakaları al

  6. Tales from the grave: Opposing autopsy reports from a body exhumed.

    Science.gov (United States)

    Gunasekera, R S; Brown, A B; Costas, E H

    2012-07-01

    We report an autopsy case of a 42-year-old woman who, when discovered, had been dead in her apartment for approximately 1 week under circumstances involving treachery, assault and possible drug overdose. This case is unique as it involved two autopsies of the deceased by two different medical examiners who reached opposing conclusions. The first autopsy was performed about 10 days after death. The second autopsy was performed after an exhumation approximately 2 years after burial. Evidence collected at the crime scene included blood samples from which DNA was extracted and analysed, fingerprints and clothing containing dried body fluids. The conclusion of the first autopsy was accidental death due to cocaine toxicity; the conclusion of the second autopsy was death due to homicide given the totality of evidence. Suspects 1 and 2 were linked to the death of the victim by physical evidence and suspect 3 was linked by testimony. Suspect 1 received life in prison, and suspects 2 and 3 received 45 and 20 years in prison, respectively. This case indicates that cocaine toxicity is difficult to determine in putrefied tissue and that exhumations can be important in collecting forensic information. It further reveals that the combined findings of medical examiners, even though contradictory, are useful in determining the circumstances leading to death in criminal justice. Thus, this report demonstrates that such criminal circumstances require comparative forensic review and, in such cases, scientific conclusions can be difficult. Published by Elsevier Ltd.

  7. Postmortem CT versus forensic autopsy: frequent discrepancies of tracheobronchial content findings.

    Science.gov (United States)

    Zech, Wolf-Dieter; Jackowski, Christian; Schwendener, Nicole; Brencicova, Eva; Schuster, Frederick; Lombardo, Paolo

    2016-01-01

    In their daily forensic casework, the authors experienced discrepancies of tracheobronchial content findings between postmortem computed tomography (PMCT) and autopsy to an extent previously unnoticed in the literature. The goal of this study was to evaluate such discrepancies in routine forensic cases. A total of 327 cases that underwent PMCT prior to routine forensic autopsy were retrospectively evaluated for tracheal and bronchial contents according to PMCT and autopsy findings. Hounsfield unit (HU) values of tracheobronchial contents, causes of death, and presence of pulmonary edema were assessed in mismatching and matching cases. Comparing contents in PMCT and autopsy in each of the separately evaluated compartments of the respiratory tract low positive predictive values were assessed (trachea, 38.2%; main bronchi, 40%; peripheral bronchi, 69.1%) indicating high discrepancy rates. The majority of tracheobronchial contents were viscous stomach contents in matching cases and low radiodensity materials (i.e., HU cases. The majority of causes of death were cardiac related in the matching cases and skull/brain trauma in the mismatching cases. In mismatching cases, frequency of pulmonary edema was significantly higher than in matching cases. It can be concluded that discrepancies in tracheobronchial contents observed between PMCT and routine forensic autopsy occur in a considerable number of cases. Discrepancies may be explained by the runoff of contents via nose and mouth during external examination and the flow back of tracheal and main bronchial contents into the lungs caused by upright movement of the respiratory tract at autopsy.

  8. Fatal overdose from synthetic cannabinoids and cathinones in Japan: demographics and autopsy findings.

    Science.gov (United States)

    Ezaki, Jiro; Ro, Ayako; Hasegawa, Masayuki; Kibayashi, Kazuhiko

    2016-09-01

    Sixty-one autopsy cases involving cathinones and/or cannabinoids (synthetic cathinones/cannabinoids) use have been reported. However, little is known about the demographics and autopsy findings in fatal synthetic cathinones/cannabinoids users. To elucidate demographic and autopsy findings (i.e. major organ pathology and causes of death) in synthetic cathinones/cannabinoids cases. We reviewed forensic autopsy reports in Department of Legal Medicine of Tokyo Women's Medical University (Tokyo, Japan) between 2011 and 2015 (a total of 359). We compared demographic and autopsy findings between synthetic cathinones/cannabinoids and methamphetamine cases (as control subjects). There were 12 synthetic cathinones/cannabinoids cases and 10 methamphetamine cases. Synthetic cathinones/cannabinoids users were significantly younger than methamphetamine users (p cannabinoids and methamphetamine. Acute intoxication and cardiac ischemia were the two most prominent causes of death in both synthetic cathinones/cannabinoids users and methamphetamine users. Excited delirium syndrome and pulmonary aspiration were found only in synthetic cathinones/cannabinoids cases. The populations of synthetic cathinones/cannabinoids and methamphetamine users who died of an overdose are different in Japan. Acute intoxication, cardiac ischemia, excited delirium syndrome, pulmonary aspiration, and drowning are the major autopsy findings in synthetic cathinones/cannabinoids-related death. Clinicians shuld be aware of these potentially fatal complications in the medical management of synthetic cathinones/cannabinoids users.

  9. Is there a need for autopsies in the management of fungal disease?

    Science.gov (United States)

    Knoke, Manfred; Bernhardt, Hannelore; Schwesinger, Günther

    2008-07-01

    The autopsy rates in Germany became low like in other European, American and Asian countries. Main reasons for this development are the lack of acceptance of autopsy in the society as well as in the medical profession, the introduction of a requirement for consent, unclear legal position, the public health system, pressure of costs and a change in the field of activity in pathology with much more diagnostics of surgical and biopsy material. The autopsy is missing with respect to the reliability of causes of death and morbidity statistics and other epidemiological studies. Published data indicate that up to 20-30% of patients who die in hospitals have important diseases/lesions that remain undetected before death but that are found at autopsy. For infectious diseases, the data are similar. Therefore, a higher incidence of invasive fungal infections was found. Some rare fungal disorders are diagnosed by autopsy. Only exact death statistics makes specific health care possible and is cost saving in a public health system in the long term. Autopsy remains an important tool for quality control in medical diagnostic and therapeutic activity. It is also essential for fundamental medical education and further training.

  10. Autopsy rate in suicide is low among elderly in Denmark compared with Finland

    DEFF Research Database (Denmark)

    Ylijoki-Sørensen, Seija; Boel, Lene Warner Thorup; Boldsen, Jesper Lier

    2014-01-01

    suicide. Data from the mortality registries were summarised for the years 2000, 2005 and 2010. Autopsy rates (total, forensic and medical) were analysed with regard to deaths classified as suicide, and they were compared for three age groups (1-50 years, 51-70 years and ≥71 years) and for causes of death...... for suicides was 99.8% in Finland and 13.2% in Denmark. Almost all of these autopsies were conducted as forensic autopsies. In the age group ≥71 years, Danish suicides outnumbered Finnish suicides (410 versus 283). The total autopsy rate was lower in the more senior age group in Denmark (19.5%, 9.9%, 5......). In Denmark, the decision regarding the need, if any, for a forensic autopsy is made during the external forensic examination of the body. Our study showed that the limited use of forensic autopsy to confirm the cause of death in deaths classified as suicides raises doubts about the accuracy of the Danish...

  11. 2008 South Carolina Department of Natural Resources (SCDNR) South Carolina Lidar - Lancaster County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  12. 2008 South Carolina Department of Natural Resources (SCDNR) South Carolina Lidar - Dillon County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  13. 2008 South Carolina Department of Natural Resources (SCDNR) South Carolina Lidar - Darlington County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  14. 2008 South Carolina Department of Natural Resources (SCDNR) South Carolina Lidar - Orangeburg County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  15. 2008 South Carolina Department of Natural Resources (SCDNR) South Carolina Lidar - Newberry County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  16. 2008 South Carolina Department of Natural Resources (SCDNR) South Carolina Lidar - Marion County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  17. 2008 South Carolina Department of Natural Resources (SCDNR) South Carolina Lidar - Cherokee County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  18. 2008 South Carolina Department of Natural Resources (SCDNR) South Carolina Lidar - Chester County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  19. 2008 South Carolina Department of Natural Resources (SCDNR) South Carolina Lidar - Chesterfield County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  20. 2008 South Carolina Department of Natural Resources (SCDNR) South Carolina Lidar - Williamsburg County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  1. 2008 South Carolina Department of Natural Resources (SCDNR) South Carolina Lidar - Laurens County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  2. 2008 South Carolina Department of Natural Resources (SCDNR) South Carolina Lidar - Union County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  3. 2008 South Carolina Department of Natural Resources (SCDNR) South Carolina Lidar - Marlboro County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  4. 2008 South Carolina Department of Natural Resources (SCDNR) South Carolina Lidar - Greenwood County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  5. 2008 South Carolina Department of Natural Resources (SCDNR) South Carolina Lidar - Fairfield County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  6. 2008 South Carolina Department of Natural Resources (SCDNR) South Carolina Lidar - Clarendon County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project area is composed of 16 counties in the State of South Carolina - Cherokee, Union, Laurens, Greenwood, Newberry, Chester, Fairfield, Lancaster,...

  7. Residential Energy Efficiency Potential: South Carolina

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Eric J [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-11-02

    Energy used by South Carolina single-family homes that can be saved through cost-effective improvements. Prepared by Eric Wilson and Noel Merket, NREL, and Erin Boyd, U.S. Department of Energy Office of Energy Policy and Systems Analysis.

  8. Residential Energy Efficiency Potential: North Carolina

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Eric J [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-11-02

    Energy used by North Carolina single-family homes that can be saved through cost-effective improvements. Prepared by Eric Wilson and Noel Merket, NREL, and Erin Boyd, U.S. Department of Energy Office of Energy Policy and Systems Analysis.

  9. Carolina bays of the Savannah River Plant

    Energy Technology Data Exchange (ETDEWEB)

    Schalles, J.F. (Creighton Univ., Omaha, NE (USA)); Sharitz, R.R.; Gibbons, J.W.; Leversee, G.J.; Knox, J.N. (Savannah River Ecology Lab., Aiken, SC (USA))

    1989-01-01

    Much of the research to date on the Carolina bays of the Savannah River Plant and elsewhere has focused on certain species or on environmental features. Different levels of detail exist for different groups of organisms and reflect the diverse interests of previous investigators. This report summarizes aspects of research to date and presents data from numerous studies. 70 refs., 14 figs., 12 tabs.

  10. South Carolina Superintendents' Change Style Preferences

    Science.gov (United States)

    Melton, Annette Ghent; Cox, Edward P.

    2010-01-01

    Little is known about the change style preferences of superintendents, and how they differ from school principals and from business leaders and whether a superintendent's change-style preference affects student achievement. The purpose of this study was to explore the change-style preferences of South Carolina superintendents, compare them with…

  11. The South Carolina Framework for Music Education.

    Science.gov (United States)

    Doughty, Ray

    This document is a South Carolina curriculum model that identifies four broad areas of study. These components, which should be present in all music education courses, are: (1) aesthetic perception and concept development; (2) creative expression and skills development; (3) music heritage, both historical and cultural; and (4) aesthetic valuing,…

  12. AN OBJECTIVE CLIMATOLOGY OF CAROLINA COASTAL FRONTS

    Science.gov (United States)

    This study describes a simple objective method to identify cases of coastal frontogenesis offshore of the Carolinas and to characterize the sensible weather associated with frontal passage at measurement sites near the coast. The identification method, based on surface hourly d...

  13. South Carolina: How Did It Happen?

    Science.gov (United States)

    Hatfield, Thomas A.; Mahlmann, John J.

    1980-01-01

    In July 1980 a new state regulation went into effect requiring South Carolina schools to employ art, music, and physical education specialists for the elementary grades. In this interview, Thomas Hatfield, a state Department of Education art consultant, discusses the lobbying leading to this regulation and its potential impact. (SJL)

  14. case series

    African Journals Online (AJOL)

    Administrator

    Conclusions: The concept of “case series” is not well defined in the literature and does not reflect a specific research design. We suggest that a case series should have more than four patients while four paitents or less should be reported individually as case reports. Key words: Case report, case series, concept analysis, ...

  15. PROFIL KASUS AUTOPSI PADA ANAK DI PROVINSI RIAU PERIODE TAHUN 2010-2014

    Directory of Open Access Journals (Sweden)

    Mohammad Tegar Indrayana

    2015-12-01

    Full Text Available AbstrakAutopsi pada anak memiliki peranan penting guna mengetahui penyebab kematian tidak wajar pada anak. Penelitian ini bertujuan untuk mengetahui profil kasus autopsi pada anak di Provinsi Riau periode tahun 2010-2014. Data diperoleh dari Visum et Repertum jenazah milik Biddokkes Polda Riau yang dianggap dapat mewakilkan gambaran se-Provinsi Riau. Hasil penelitian didapatkan angka autopsi pada anak di Provinsi Riau periode tahun 2010-2014 berjumlah 15 kasus. Karakteristik korban anak didominasi anak laki-laki (66,7% berumur 0-5 tahun (46,7%. Didapatkan 5 kasus kekerasan tumpul, 3 kasus kekerasan tajam dan 7 kasus tidak dapat digolongkan jenis kekerasannya. Jenis luka akibat kekerasan tajam didominasi oleh luka sayat (66,7% dengan lokasi luka tersering di leher (100% sedangkan jenis luka akibat kekerasan tumpul didominasi oleh luka memar (60% dengan lokasi luka tersering di kepala (80%. Seluruh kasus merupakan kematian tidak wajar dengan kasus terbanyak adalah dugaan pembunuhan (60%. Polsek Kabupaten Kampar merupakan asal polsek tersering (40%.AbstractAutopsy is an important procedure to detecting cause of death in child unnatural death cases. This study aims to describe the profile of child autopsy in Riau Province, Indonesia 2010-2014. Data was obtained from medicolegal autopsy reports that belongs to Riau Regional Police on Medicine and Health. Data is assumed could covered Riau Province child autopsy insidences. There were 15 child medicolegal autopsies recorded between 2010 and 2014 with boy (66,7% aged 0 to 5 years old (46,7% were dominant victims. Of the 15 child medicolegal autopsies, 5 cases were blunt force violence, 3 cases were sharp force violence, and 7 were uncategorized. Incised wound (66,7% was lead type of wounds on sharp force violence which localized on neck (100%. Contusions (60% was lead type of wounds on blunt force violence which often localized on head (80%. Our study highlights that homicide was the predominant manner

  16. Necessity of including medico-legal autopsy data in epidemiological surveys of individuals with major trauma.

    Science.gov (United States)

    Bagher, A; Wingren, C J; Ottosson, A; Andersson, L; Wangefjord, S; Acosta, S

    2015-08-01

    It is rare that epidemiological surveys of patients with major trauma include both those admitted to the emergency department and those sent for medico-legal autopsy. The main aim of the present population-based study of major trauma was to examine the importance of medico-legal autopsy data. A new injury severity score (NISS)>15 or lethal outcome was used as criteria for major trauma and to identify patients at the emergency, anaesthesiology and forensic departments and/or being within the jurisdiction of the Malmö police authority and subjected to a medico-legal autopsy between 2011 and 2013. According to Swedish legislation all trauma related deaths should be reported to the police who refer these cases for medico-legal autopsy. Among the 174 individuals included, 92 (53%) died and 81 (47%) underwent medico-legal autopsy. One hundred twenty-six patients were primarily admitted to hospital and 48 died before admission to hospital and were sent directly for medico-legal autopsy. Forty-four in-hospital deaths occurred, of whom 33 (75%) were sent to medico-legal autopsy. In those sent directly to the department of forensic medicine the proportion of accidents was lower (pforensic toxicology screening in the 81 fatalities were ethanol (20%), sedatives (16%), anti-depressives (15%) and illicit narcotics (9%). Forty-four cases (54%) were positive for at least one drug, and twenty-eight cases (35%) were positive for two or more drugs. Factors associated with a lower rate of medico-legal autopsies among trauma-related deaths at hospital were high age (pforensic data shows that more than half of the individuals sustaining major trauma died. An additional 25% of the in-hospital fatalities should have undergone medico-legal autopsy according to legislation, but did not. The high proportion of positive toxicological findings among fatalities examined at medico-legal autopsy implies that toxicology screening should be routine in major trauma patients, in order to improve

  17. Autopsy rate in suicide is low among elderly in Denmark compared with Finland.

    Science.gov (United States)

    Ylijoki-Sørensen, Seija; Boldsen, Jesper Lier; Boel, Lene Warner Thorup; Bøggild, Henrik; Lalu, Kaisa; Sajantila, Antti

    2014-11-01

    National differences in the legislation on cause and manner of death investigation are reflected in a high autopsy rate in suicides in Finland and a low corresponding rate in Denmark. The consequences for mortality statistics of these different investigation practices on deaths classified as suicides in Denmark and Finland, respectively, are not known in detail. The aim of this article was to analyse autopsy rates in deaths classified as suicides, and to identify any differences in investigation practices in deaths with a comparable cause of death, but classified as unnatural deaths other than suicide. Data from the mortality registries were summarised for the years 2000, 2005 and 2010. Autopsy rates (total, forensic and medical) were analysed with regard to deaths classified as suicide, and they were compared for three age groups (1-50 years, 51-70 years and ≥71 years) and for causes of death. Deaths classified as suicide were compared with other unnatural classifications, and comparable causes of death were coded into six subgroups: poisonings, suffocations/strangulations, firearm discharges, drowning/submersions, explosions/flames and other/unspecified causes. The total autopsy rate for suicides was 99.8% in Finland and 13.2% in Denmark. Almost all of these autopsies were conducted as forensic autopsies. In the age group ≥71 years, Danish suicides outnumbered Finnish suicides (410 versus 283). The total autopsy rate was lower in the more senior age group in Denmark (19.5%, 9.9%, 5.6%), whereas it was consistently high in Finland (99.8%, 99.9%, 99.6%). Among Danish deaths due to poisonings, the autopsy rate was 89.5% when these were classified as accidents, but only 20.7% for cases classified as suicides. The number of deaths in the two Danish subgroups was comparable (550 versus 553). In Denmark, the decision regarding the need, if any, for a forensic autopsy is made during the external forensic examination of the body. Our study showed that the limited use

  18. Validity of a minimally invasive autopsy tool for cause of death determination in pediatric deaths in Mozambique: An observational study.

    Directory of Open Access Journals (Sweden)

    Quique Bassat

    2017-06-01

    Full Text Available In recent decades, the world has witnessed unprecedented progress in child survival. However, our knowledge of what is killing nearly 6 million children annually in low- and middle-income countries remains poor, partly because of the inadequacy and reduced precision of the methods currently utilized in these settings to investigate causes of death (CoDs. The study objective was to validate the use of a minimally invasive autopsy (MIA approach as an adequate and more acceptable substitute for the complete diagnostic autopsy (CDA for pediatric CoD investigation in a poor setting.In this observational study, the validity of the MIA approach in determining the CoD was assessed in 54 post-neonatal pediatric deaths (age range: ≥1 mo to 15 y in a referral hospital of Mozambique by comparing the results of the MIA with those of the CDA. Concordance in the category of disease obtained by the two methods was evaluated by the Kappa statistic, and the sensitivity, specificity, and positive and negative predictive values of the MIA diagnoses were calculated. A CoD was identified in all cases in the CDA and in 52/54 (96% of the cases in the MIA, with infections and malignant tumors accounting for the majority of diagnoses. The MIA categorization of disease showed a substantial concordance with the CDA categorization (Kappa = 0.70, 95% CI 0.49-0.92, and sensitivity, specificity, and overall accuracy were high. The ICD-10 diagnoses were coincident in up to 75% (36/48 of the cases. The MIA allowed the identification of the specific pathogen deemed responsible for the death in two-thirds (21/32; 66% of all deaths of infectious origin. Discrepancies between the MIA and the CDA in individual diagnoses could be minimized with the addition of some basic clinical information such as those ascertainable through a verbal autopsy or clinical record. The main limitation of the analysis is that both the MIA and the CDA include some degree of expert subjective

  19. Deaths of infants subject to forensic autopsy in Estonia from 2001 to 2005: what can we learn from additional information?

    Directory of Open Access Journals (Sweden)

    Grjibovski Andrej M

    2010-10-01

    Full Text Available Abstract Background Deaths from childhood injury are a public health problem worldwide. A relatively high proportion of child deaths of undetermined manner in Estonia raises concerns about potential underestimation of intentional deaths, especially in infants. This suggests that more information on the circumstances surrounding death is needed to establish the manner of death correctly and, more importantly, to prevent these deaths. The objective of this study was to detect, describe, and analyze the circumstances around deaths of infants subject to forensic autopsy in Estonia to reveal hidden cases of child abuse and more accurately determine causes of death. Methods Study cases included all infant deaths in Estonia from 2001 to 2005 subject to forensic autopsy at the Estonian Bureau of Forensic Medicine. Additional information was obtained from a series of visits to general practitioners, including characteristics of infant health, family composition, parents' education and employment, living conditions, and circumstances around death as perceived by medical staff in charge of outpatient services for these families. Results The total number of infant deaths in Estonia between 2001 and 2005 subject to forensic autopsy was 98, with 40 (40.8% deaths attributed to a disease and 58 deaths (59.2% resulting from injury. Elements of child abuse were involved in as many as 57.7% (95% CI 46.9-68.1 of the deaths for which medical records were available (n = 90. At death, the majority of these cases were registered as diseases or deaths from unintentional injury. Average annual mortality from external causes in Estonian infants, 2001-2005, previously reported by us as 88.1 per 100,000 (95% CI 68.1-113.6 would decrease to 41.0 (95% CI 26.9-57.8. Many infants in the studied group had faced multiple threats and were living in poor hygienic conditions. In a number of cases, they were left alone or looked after by older siblings. Parents' alcohol abuse played

  20. Deaths of infants subject to forensic autopsy in Estonia from 2001 to 2005: what can we learn from additional information?

    Science.gov (United States)

    2010-01-01

    Background Deaths from childhood injury are a public health problem worldwide. A relatively high proportion of child deaths of undetermined manner in Estonia raises concerns about potential underestimation of intentional deaths, especially in infants. This suggests that more information on the circumstances surrounding death is needed to establish the manner of death correctly and, more importantly, to prevent these deaths. The objective of this study was to detect, describe, and analyze the circumstances around deaths of infants subject to forensic autopsy in Estonia to reveal hidden cases of child abuse and more accurately determine causes of death. Methods Study cases included all infant deaths in Estonia from 2001 to 2005 subject to forensic autopsy at the Estonian Bureau of Forensic Medicine. Additional information was obtained from a series of visits to general practitioners, including characteristics of infant health, family composition, parents' education and employment, living conditions, and circumstances around death as perceived by medical staff in charge of outpatient services for these families. Results The total number of infant deaths in Estonia between 2001 and 2005 subject to forensic autopsy was 98, with 40 (40.8%) deaths attributed to a disease and 58 deaths (59.2%) resulting from injury. Elements of child abuse were involved in as many as 57.7% (95% CI 46.9-68.1) of the deaths for which medical records were available (n = 90). At death, the majority of these cases were registered as diseases or deaths from unintentional injury. Average annual mortality from external causes in Estonian infants, 2001-2005, previously reported by us as 88.1 per 100,000 (95% CI 68.1-113.6) would decrease to 41.0 (95% CI 26.9-57.8). Many infants in the studied group had faced multiple threats and were living in poor hygienic conditions. In a number of cases, they were left alone or looked after by older siblings. Parents' alcohol abuse played an important role in a

  1. Distribution of Aconitum alkaloids in autopsy cases of aconite poisoning.

    Science.gov (United States)

    Niitsu, Hisae; Fujita, Yuji; Fujita, Sachiko; Kumagai, Reiko; Takamiya, Masataka; Aoki, Yasuhiro; Dewa, Koji

    2013-04-10

    Aconite is a well-known toxic-plant containing Aconitum alkaloids such as aconitines, benzoylaconines, and aconins. We describe here the distribution of Aconitum alkaloids detected by liquid chromatography-tandem mass spectrometry (LC/MS/MS) in three autopsy cases of suicide by aconite poisoning. Case 1: a male in his fifties had eaten aconite leaves. The concentrations of jesaconitine in cardiac blood, urine, and kidney were 12.1 ng/ml, 993.0 ng/ml, and 114.2 ng/g, respectively. Case 2: a female in her fifties had eaten aconite root. The aconite root in the stomach included a high level of mesaconitine. The concentrations of mesaconitine in cardiac blood, liver, and kidney were 69.1 ng/ml, 960.9 ng/g, and 776.9 ng/g, respectively. Case 3: a male in his sixties had drunk liquor in which aconite root had been soaked. The concentrations of mesaconitine and aconitine in cardiac blood were 259.5 and 228.5 ng/ml, respectively. The Aconitum alkaloid levels were very high in the liver. The absorption of ethanol and Aconitum alkaloids might have been increased because of his having undergone total gastrectomy. In all three cases, the Aconitum alkaloid levels were high in the liver and kidney and low in the heart and cerebrum. The level in the cerebrum was lower than that in blood. Data on the distribution of the Aconitum alkaloids in the body in cases of aconite poisoning is useful to elucidate various actions of aconite alkaloids. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  2. Coronary atherosclerosis in sudden cardiac death: An autopsy study

    Directory of Open Access Journals (Sweden)

    Sudha M

    2009-10-01

    Full Text Available Background: The incidence of ischemic heart disease (IHD has markedly increased in India over the past few years. Considering the variations in racial, dietary and lifestyle patterns in our population, it is essential to study the biology of coronary atherosclerosis in our patients. Vulnerable plaques have a large number of foam cells, extracellular lipid, thin fibrous caps and clusters of inflammatory cells and are more prone to rupture. These plaques are nourished by the microvessels arising from the vasa vasorum of the blood vessels and by lumen-derived microvessels through the fibrous cap. This autopsy study was designed to analyse the coronary arterial tree in cases of sudden cardiac death, classify coronary atherosclerotic plaques and to assess the factors contributing to vulnerability of the plaques including inflammation, calcification and microvascular density. Materials and Methods: Seven cases of sudden cardiac death were included in the study. The hearts were perfusion-fixed and the coronary arteries along with their main branches were dissected and studied. The location of the plaques, type of plaques, presence of inflammation and calcification were assessed. The cap thickness and microvessel density per 1000um 2 were assessed. The statistical significance was estimated. Results and Conclusions: Extensive high-grade coronary atherosclerotic disease was seen in all sudden cardiac death cases. Majority of the plaques were vulnerable. High-grade inflammation was seen in most of the vulnerable and ruptured plaques. All the ruptured plaques were uncalcified indicating that calcification probably stabilizes the plaques and protects against rupture. Increased microvessel density was noted in ruptured plaques compared to vulnerable plaques. However, it was not statistically significant.

  3. Characterizing measles transmission in India: a dynamic modeling study using verbal autopsy data.

    Science.gov (United States)

    Verguet, Stéphane; Jones, Edward O; Johri, Mira; Morris, Shaun K; Suraweera, Wilson; Gauvreau, Cindy L; Jha, Prabhat; Jit, Mark

    2017-08-10

    Decreasing trends in measles mortality have been reported in recent years. However, such estimates of measles mortality have depended heavily on assumed regional measles case fatality risks (CFRs) and made little use of mortality data from low- and middle-income countries in general and India, the country with the highest measles burden globally, in particular. We constructed a dynamic model of measles transmission in India with parameters that were empirically inferred using spectral analysis from a time series of measles mortality extracted from the Million Death Study, an ongoing longitudinal study recording deaths across 2.4 million Indian households and attributing causes of death using verbal autopsy. The model was then used to estimate the measles CFR, the number of measles deaths, and the impact of vaccination in 2000-2015 among under-five children in India and in the states of Bihar and Uttar Pradesh (UP), two states with large populations and the highest numbers of measles deaths in India. We obtained the following estimated CFRs among under-five children for the year 2005: 0.63% (95% confidence interval (CI): 0.40-1.00%) for India as a whole, 0.62% (0.38-1.00%) for Bihar, and 1.19% (0.80-1.75%) for UP. During 2000-2015, we estimated that 607,000 (95% CI: 383,000-958,000) under-five deaths attributed to measles occurred in India as a whole. If no routine vaccination or supplemental immunization activities had occurred from 2000 to 2015, an additional 1.6 (1.0-2.6) million deaths for under-five children would have occurred across India. We developed a data- and model-driven estimation of the historical measles dynamics, CFR, and vaccination impact in India, extracting the periodicity of epidemics using spectral and coherence analysis, which allowed us to infer key parameters driving measles transmission dynamics and mortality.

  4. The use of CT-scanning at the medicolegal external postmortem examination and at the forensic autopsy

    DEFF Research Database (Denmark)

    Leth, Peter Mygind

    2006-01-01

    Introduction: Can CT-scanning of deceased at the medico legal external examination improve the selection of cases to autopsy? Is CT-scanning a substitute or a supplement to the traditional forensic autopsy? Material: In 2006 60 deceased individuals from Southern Denmark (counties of Fyn...... and Sønderjylland) (15 females and 45 males) were CT-scanned before autopsy. Method: A double-blind prospective investigation of CT-scanning in autopsy cases. A multislice spiral CT-scanner (Siemens Somatom Spirit) was used. Data from the CT-scanning and the autopsy were registered in a computer database...... and compared. Results: The scanning could be performed in 10 minutes per case. In approximately a third of the cases the cause of death could be established by CT-scanning alone. CT-scanning was found to be most useful in cases of traumatic death, and was superior to autopsy in visualizing fractures...

  5. Traumatic brain injury: Comparison between autopsy and ante-mortem CT.

    Science.gov (United States)

    Panzer, Stephanie; Covaliov, Lidia; Augat, Peter; Peschel, Oliver

    2017-11-01

    The aim of this study was to compare pathological findings after traumatic brain injury between autopsy and ante-mortem computed tomography (CT). A second aim was to identify changes in these findings between the primary posttraumatic CT and the last follow-up CT before death. Through the collaboration between clinical radiology and forensic medicine, 45 patients with traumatic brain injury were investigated. These patients had undergone ante-mortem CT as well as autopsy. During autopsy, the brain was cut in fronto-parallel slices directly after removal without additional fixation or subsequent histology. Typical findings of traumatic brain injury were compared between autopsy and radiology. Additionally, these findings were compared between the primary CT and the last follow-up CT before death. The comparison between autopsy and radiology revealed a high specificity (≥80%) in most of the findings. Sensitivity and positive predictive value were high (≥80%) in almost half of the findings. Sixteen patients had undergone craniotomy with subsequent follow-up CT. Thirteen conservatively treated patients had undergone a follow-up CT. Comparison between the primary CT and the last ante-mortem CT revealed marked changes in the presence and absence of findings, especially in patients with severe traumatic brain injury requiring decompression craniotomy. The main pathological findings of traumatic brain injury were comparable between clinical ante-mortem CT examinations and autopsy. Comparison between the primary CT after trauma and the last ante-mortem CT revealed marked changes in the findings, especially in patients with severe traumatic brain injury. Hence, clinically routine ante-mortem CT should be included in the process of autopsy interpretation. Copyright © 2017 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  6. Utility of desmin and a Masson's trichrome method to detect early acute myocardial infarction in autopsy tissues

    OpenAIRE

    Ouyang, Jie; Guzman, Miguel; Desoto-Lapaix, Fidelina; Pincus, Matthew R.; Wieczorek, Rosemary

    2010-01-01

    Detection of early acute myocardial ischemia/infarction prior to neutrophilic infiltration in autopsy myocardium poses a diagnostic dilemma to the surgical pathologist. Morphological changes can be subtle or not identified at all on the hematoxylin and eosin stain. To evaluate the Masson's trichrome stain and immunohistochemical stains, desmin and myoglobin, in detecting acute myocardial ischemia/infarction in autopsy myocardium. We reviewed the autopsy files of the New York Harbor Healthcare...

  7. SERIES ARTICLES

    Indian Academy of Sciences (India)

    IAS Admin

    347 Impact of Theoretical Chemistry on Chemical and. Biological Sciences. Chemistry Nobel Prize – 2013. Saraswathi Vishveshwara. SERIES ARTICLES. 368 Ecology: From Individuals to Collectives. A Physicist's Perspective on Ecology. Vishwesha Guttal. 310. 368 ...

  8. SERIES ARTICLES

    Indian Academy of Sciences (India)

    ensis fruit. 4. SERIES ARTICLES. Evolution of the Atmosphere and Oceans: Evidence from Geological Records. Evolution of the Early Atmosphere. P V Sukumaran. 11 Electrostatics in Chemistry. Electrostatic Models for Weak Molecular ...

  9. Chart Series

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Centers for Medicare and Medicaid Services (CMS) offers several different Chart Series with data on beneficiary health status, spending, operations, and quality...

  10. Codeine to morphine concentration ratios in samples from living subjects and autopsy cases after incubation.

    Science.gov (United States)

    Berg-Pedersen, Riikka Mari; Ripel, Ase; Karinen, Ritva; Vevelstad, Merete; Bachs, Liliana; Vindenes, Vigdis

    2014-03-01

    The codeine to morphine concentration ratio is used in forensic toxicology to assess if codeine has been ingested alone or if morphine and/or heroin have been ingested in addition. In our experience, this interpretation is more difficult in autopsy cases compared with samples from living persons, since high morphine concentrations are observed in cases where only codeine is assumed to have been ingested. We have investigated if codeine and morphine glucuronides are subject to cleavage to the same extent in living and autopsy cases in vitro. We included whole blood samples from eight living subjects and nine forensic autopsy cases, where only codeine ingestion was suspected. All samples were incubated for 2 weeks at 37°C and analyzed for codeine and six codeine metabolites using liquid chromatography tandem mass spectrometry. A reduction in the codeine to morphine concentration ratio was found, both in samples from living subjects (mean 33%, range 22-50%) and autopsy cases (mean 37%, range 13-54%). The increase in the morphine concentrations was greater in the autopsy cases (mean 85%, max 200%) compared with that of the living cases (mean 51%, max 87%). No changes were seen for codeine or codeine-6-glucuronide concentrations. The altered ratios might mislead the forensic toxicologist to suspect morphine or heroin consumption in cases where only codeine has been ingested.

  11. Postmortem examination of human fetuses: a comparison of 2-dimensional ultrasound with invasive autopsy.

    Science.gov (United States)

    Kang, Xin; Shelmerdine, Susan C; Hurtado, Ivan; Bevilacqua, Elisa; Hutchinson, Ciaran; Mandalia, Uday; Segers, Valerie; Cos Sanchez, Teresa; Cannie, Mieke M; Carlin, Andrew; Sebire, Neil J; Arthurs, Owen J; Jani, Jacques C

    2017-08-07

    To compare the diagnostic usefulness of postmortem ultrasound with invasive autopsy in fetuses at different gestational ages. We performed postmortem 2-dimensional ultrasound on 163 fetuses at 13-42 weeks gestation, blinded to clinical details. Logistic regression analysis was used to investigate the effect on non-diagnostic results of gestational age during postmortem ultrasound, presence of maceration, and cause of death. In 123 cases where invasive autopsy was available, the diagnostic accuracy of ultrasound in detecting major organ abnormalities was evaluated, using invasive autopsy as a gold standard. For the fetal brain, a non-diagnostic result was found in 17 (39.5%) of 43 fetuses with maceration and was significantly more common as compared to fetuses without maceration (24 [20.0%] of 120 fetuses [p=0.013]). For the fetal thorax, a non-diagnostic result was found in 15 (34.1%) of 44 fetuses at autopsy. It may therefore play a role as a first-line examination before other virtual autopsy techniques are indicated. This article is protected by copyright. All rights reserved.

  12. Advancing the state-of-the-art for Virtual Autopsies--initial forensic workflow study.

    Science.gov (United States)

    Scandurra, Isabella; Forsell, Camilla; Ynnerman, Anders; Ljung, Patric; Lundström, Claes; Persson, Anders

    2010-01-01

    There are numerous advantages described of how imaging technology can support forensic examinations. However, postmortem examinations of bodies are mainly performed to address demands which differ from those of traditional clinical image processing. This needs to be kept in mind when gathering information from image data sets for forensic purposes. To support radiologists and forensic clinicians using Virtual Autopsy technologies, an initial workflow study regarding post-mortem imaging has been performed, aiming to receive an improved understanding of how Virtual Autopsy workstations, image data sets and processes can be adjusted to support and improve conventional autopsies. This paper presents potential impacts and a current forensic Virtual Autopsy workflow aiming to form a foundation for collaborative procedures that increase the value of Virtual Autopsy. The workflow study will provide an increased and mutual understanding of involved professionals. In addition, insight into future forensic workflows based on demands from both forensic and radiologist perspectives bring visualization and medical informatics researchers together to develop and improve the technology and software needed.

  13. Determination of Consistency and Reliability of Diagnostic Accuracy Derived From Autopsy Photographs

    Directory of Open Access Journals (Sweden)

    Çiğdem Süner

    2002-12-01

    Full Text Available Forensic photography plays a significant role in investigation and recording in criminological procedures. Photographs are used as a document in many instances and sometimes becomes a part of an investigation method. Photographs taken at the scene, during the autopsy or examination, might be inspected again for education purposes or in order to revise the details and obtain consultation from other specialists. In this study, determination of the consistency and reliability of diagnosis derived from the photographs taken from firearm injuries during the autopsies is aimed. The cases were chosen randomly among the firearm injury cases, in the Morgue Specialization Department in the Institute of Forensic Medicine, Ministery of Justice, between October 2001 and April 2002. Forensic medicine specialists evaluated lesions of 18 cases at the autopsy and photographs were taken with a 35 mm camera using dia-positive films. The photographs evaluated independently by four forensic specialists twice in a month interval. In order to evaluate the reliability of diagnosis from photographs, the ‘gold standard’ findings which had been defined in the autopsy were compared with the findings of photograph examination. Self-consistency of each reviewer was estimated with kappa test. The study was designed in double-blind. The significance value was accepted as p 0.05. Keywords: Forensic photography, autopsy, firearm injuries.

  14. Validation of verbal autopsy tool for ascertaining the causes of stillbirth.

    Science.gov (United States)

    Nausheen, Sidrah; Soofi, Sajid B; Sadiq, Kamran; Habib, Atif; Turab, Ali; Memon, Zahid; Khan, M Imran; Suhag, Zamir; Bhatti, Zaid; Ahmed, Imran; Bahl, Rajiv; Bhutta, Shireen; Bhutta, Zulfiqar A

    2013-01-01

    To assess performance of the WHO revised verbal autopsy tool for ascertaining the causes of still birth in comparison with reference standard cause of death ascertained by standardized clinical and supportive data. All stillbirths at a tertiary hospital in Karachi, Pakistan were prospectively recruited into study from August 2006- February 2008. The reference standard cause of death was established by two senior obstetricians within 48 hours using the ICD coding system. Verbal autopsy interviews using modified WHO tool were conducted by trained health workers within 2- 6 weeks of still birth and the cause of death was assigned by second panel of obstetricians. The performance was assessed in terms of sensitivity, specificity and Kappa. There were 204 still births. Of these, 80.8% of antepartum and 50.5% of intrapartum deaths were correctly diagnosed by verbal autopsy. Sensitivity of verbal autopsy was highest 68.4%, (95%CI: 46-84.6) for congenital malformation followed by obstetric complication 57.6%, (95%CI: 25-84.2). The specificity for all major causes was greater than 90%. The level of agreement was high (kappa=0.72) for anomalies and moderate (k=0.4) for all major causes of still birth, except asphyxia. Our results suggest that verbal autopsy has reasonable validity in identifying and discriminating between causes of stillbirth in Pakistan. On the basis of these findings, we feel it has a place in resource constrained areas to inform strategic planning and mobilization of resources to attain Millennium Development Goals.

  15. Autopsy histopathology where the prosector is not a histopathologist: a proposal.

    Science.gov (United States)

    Madadin, Mohammed; Molah, Rihab; Cordner, Stephen

    2017-09-01

    Forensic pathology is a specialty that involves death investigation while clinical forensic medicine is the application of the practice of medicine to the requests of the law in relation to the living. Around the world, there is diverse practice for these two disciplines. The forensic physician or forensic doctor (sometimes, called a forensic pathologist but not a forensic histopathologist) in parts of the world such as continental Europe, the Middle East and India, practice both clinical forensic medicine and forensic pathology. This is the specialty, for the purposes of this paper, we will call forensic medicine. The forensic doctor will usually receive training in autopsy dissection, perhaps with a short training of a few months in anatomical pathology or surgical histopathology. When undertaking autopsies (involving internal as well as external examination), if it is thought histological assessment is required, the forensic doctor will sample the organs and tissues required and refer the specimens to the hospital histopathologist for microscopic examination. This division of responsibility could compromise the quality of the autopsy unless handled correctly.Where the histological assessment of the autopsy specimen is undertaken by a pathologist other than the one who dissected the body and collected the samples, standard operating procedures need to be developed to minimize the risk to the overall quality of the autopsy. We are not aware that any such procedures have been published, hence we offer an outline of what a set of such procedures might contain.

  16. [Autopsy records in Vienna since Lorenz Biermayer--a complete documentation of 195 years].

    Science.gov (United States)

    Winter, Eduard; Höflmayer, Doris; Patzak, Beatrix; Feigl, Walter

    2013-07-01

    Vienna has a long tradition of clinical autopsies. In the period from 1817 to 2012 there are over 300,000 autopsies documented in the Vienna General Hospital. From five other community hospitals with departments for pathology and some closed hospitals, autopsy reports exist since 1865. Until the nineteenth century the reports are written in Kurrent, then Latin script and since the 1920s they are stored as machine written copies. This incredible high number of preserved reports was only possible because of the tradition started by Rokitansky and the possibility of storing this large amount of records in the Pathologic anatomical collection in the Narrenturm, the Vienna Municipal Archives and various hospitals. The aim of this study was to create a documentary of the repositories of the autopsy records, to make the records available and easier accessible for different kinds of research. The autopsy records should be easier to find and access, be it for the use in statistics or other scientific projects.

  17. Should forensic autopsies be a source for medical education? A preliminary study.

    Science.gov (United States)

    Kucuker, Hudaverdi; Ozen, Oguz Aslan; Songur, Ahmet; Bas, Orhan; Demirel, Reha

    2008-01-01

    Practical anatomy sessions including dissection of cadavers are essential for anatomy courses. There are many difficulties in obtaining cadavers. In addition, hardened and discolored cadavers that are fixed with formaldehyde look unrealistic and generate apathy among students. We considered that forensic autopsies may be used as ancillary and supportive practice in anatomy education. We invited the participation of Year 2 medical students in suitable forensic autopsy cases during the course of one year. Specialists of forensic medicine and anatomy provided theoretical support through talks in their specialized fields during the autopsy. At the end of the semester, feedback questionnaire forms were prepared and the students were asked to evaluate these sessions. Forty students participated in the evaluation by completing the questionnaire. Students made positive statements about adequacy of the time of the application, consistency of the structures with theoretical and practical issues shown in anatomy lectures, and necessary explanations of the lecturers during and after the application. We think that forensic autopsies are an attractive supplementary educational model, and we have decided to continue the forensic autopsy practices. We believe that further studies on the evaluation of the sessions using a larger student population will lead to more conclusive results.

  18. Evaluating the Cause of Death in Obese Individuals: A Ten-Year Medical Autopsy Study

    Directory of Open Access Journals (Sweden)

    Jad Saab

    2015-01-01

    Full Text Available Background. Obesity is a growing public health problem associated with increased morbidity and rate of death. Postmortem examination is imperative to determine the cause of death, to detect clinically unsuspected disease entities, and consequently to determine the actual impact of obesity on patient mortality. Methods. A total of 849 adult autopsies were retrospectively reviewed. Obese (BMI ≥ 30 kg/m2 and nonobese patients were separately studied. The primary cause of death in each group was categorized into malignancy, infection, stroke, ischemic and nonischemic heart disease, pulmonary embolism, hemorrhage, and primary nonneoplastic diseases of different organ systems. Results. Of 849 autopsies, 32.3% were obese. The leading causes of death in the obese population were malignancy (31.4%, infection (25.9%, ischemic heart disease (12.8%, and pulmonary embolism (6.2%. Obese individuals were statistically more likely to die from pulmonary embolism and liver disease and less likely to die from neurologic diseases and nonischemic heart disease. Conclusion. Autopsies on obese individuals constitute a third of all adult medical autopsies in our center. Increased death rates in the obese due to pulmonary embolism and liver disease should receive special clinical attention. Autopsy findings in the obese population should contribute to overall premortem disease detection, prevention, and management.

  19. Latent prostate cancer in Japanese men who die unnatural deaths: A forensic autopsy study.

    Science.gov (United States)

    Kido, Masahito; Hitosugi, Masahito; Ishii, Kanto; Kamimura, Shuichi; Joh, Kensuke

    2015-06-15

    An accurate natural history of prostate cancer (PC) can be obtained from forensic autopsies of individuals who had performed their normal daily activities immediately before death and had not undergone long-term medical interventions. A retrospective analysis of such individuals was performed to understand the features of latent PC in Japan. The findings of forensic autopsies performed at Dokkyo Medical University from August 2002 to July 2005 on men without severely destroyed or severely decomposed tissues were collected. Two cross sections, at the base and apex of the prostate, were examined histopathologically. Data collected included basic history, cause of death, location of PC, and Gleason score. Of 196 forensically autopsied males aged 0-90 years, 24 (12.7%) had latent PC. When analyzed by age group, PC was most prevalent among individuals in their eighties (33.3%). The prevalence of PC was similar in males who died of disease and of external causes. Most PCs were located at the base of the prostate, but were present on both the anterior and posterior sides. Nine of the 24 autopsied individuals also had other diseases, with three having cancers other than PC. This is the first report of the features of latent PC in Asian men who died of unnatural causes. Forensic autopsies can clarify the natural history of PC and may help fill knowledge gaps regarding latent PC. © 2015 Wiley Periodicals, Inc.

  20. Radiography after unexpected death in infants and children compared to autopsy

    Energy Technology Data Exchange (ETDEWEB)

    Lange, Charlotte de; Stake, Gunnar [Rikshospitalet-Radiumhospitalet Medical Centre, Department of Paediatric Radiology, Oslo (Norway); Vege, Aashild [Rikshospitalet-Radiumhospitalet Medical Centre, Institute of Forensic Medicine, Oslo (Norway); Norwegian Institute of Science and Technology, Trondheim (Norway)

    2007-02-15

    Postmortem radiography may reveal skeletal and soft-tissue abnormalities of importance for the diagnosis of cause of death. To review the radiographs of children under 3 years of age who had died suddenly and unexpectedly. To compare the radiological and autopsy findings evaluating possible differences in children dying of SIDS and of an explainable cause. A total of 110 consecutive skeletal surveys performed between 1998 and 2002 were reviewed. All but one were performed before autopsy and comprised AP views of the appendicular and axial skeleton and thorax/abdomen, lateral views of the axial skeleton and thorax, and two oblique views of the ribs. Radiography and autopsy findings were compared. Causes of death were classified as SIDS/borderline SIDS (n = 52) and non-SIDS (n = 58), with one case of abuse. In 102 infants there were 150 pathological findings, 88 involving the chest, 24 skeletal, and 38 miscellaneous findings. The radiological-pathological agreement was poor concerning pulmonary findings. Skeletal findings were sometimes important for the final diagnosis. Radiography revealed many skeletal and soft-tissue findings. Pulmonary pathology was most frequently found, but showed poor agreement with autopsy findings. Recognizing skeletal findings related to abuse is important, as these may escape recognition at autopsy. (orig.)

  1. Post-mortem computed tomography compared to forensic autopsy findings: a French experience.

    Science.gov (United States)

    Le Blanc-Louvry, Isabelle; Thureau, Sophie; Duval, Cathia; Papin-Lefebvre, Frédérique; Thiebot, Jacques; Dacher, Jean Nicolas; Gricourt, Cyril; Touré, Emmanuel; Proust, Bernard

    2013-07-01

    The principal aim of our study was to establish concordance between post-mortem CT (PMCT) and forensic standard autopsy (SA) in detecting lesions according to different anatomical regions. A secondary aim was to determine the efficacy of PMCT in showing lethal lesions. PMCTs were compared with autopsies in 236 cadavers in different contexts of death. PMCT findings were assessed by two independent radiologists. Concordance between PMCT and autopsy was almost perfect in showing skull, basal skull and hyoid bone fractures as well as in detecting facial, vertebral or pelvic fractures. Both examinations were discordant in demonstrating some intracranial injuries, vascular or organ wounds (more findings showed by autopsy), as well in showing free air in anatomical cavities (more findings detected by PMCT). Moreover, PMCT was effective in determining lethal lesions in the context of craniofacial trauma or after a gunshot wound. Concordance between the findings of the two radiologists was almost perfect for each type of lesion. PMCT could be considered as effective as SA in determining the cause of death in certain traumatic events. It was also effective in showing lethal lesions and could be a useful tool in reducing the number of SA. • Post-mortem CT is increasingly performed as an alternative/adjunct to formal autopsy. • More modern CT systems provide greater anatomical scope. • PMCT can usually determine the cause of most deaths following trauma. • Prospective studies are still required to establish an algorithm for forensic CT.

  2. [Review of the drug analysis system accompanied by forensic autopsy in Finland].

    Science.gov (United States)

    Kudo, Keiko; Ishida, Tomomi; Inoue, Hiromasa; Kageura, Mitsuyoshi

    2008-11-01

    In Japan, drug analyses for forensic autopsies have been traditionally carried out at each laboratory of the Department of Forensic Medicine. However, it is difficult to maintain a high quality of drug analysis in each department due to an insufficient number of staff and lack of equipment. Therefore, the establishment of more advanced toxicology centers which can handle all drugs associated with forensic autopsies is essential. In addition, a systematic system for requesting drug analyses from each department and dealing with the results from the center is needed. The number of forensic autopsies carried out in Finland is as high as that in Japan although the population is 1/24th that of Japan, and toxicological analyses for the entire country are centralized in one place, the Laboratory of Toxicology, Department of Forensic Medicine, University of Helsinki. Since the autopsies and drug analyses are carried out at a University as in Japan, the drug analysis system in Finland can be a good model when considering the future system in Japan. Therefore, a review of the drug analysis system accompanied by forensic autopsy in Finland was carried out with the collaboration of the Departments of Forensic Medicine, University of Helsinki and University of Turku. Based on the above studies and the present situation in Japan, we discuss the future drug analysis system needed in Japan.

  3. [Significance of postmortem computed tomography in forensic autopsy and its possible issues].

    Science.gov (United States)

    Michiue, Tomomi; Ishikawa, Takaki; Nishiguchi, Tomokazu; Oritani, Shigeki; Sakurai, Terumi; Yoshida, Chiemi; Sakoda, Shigeki; Maeda, Hitoshi

    2010-12-01

    Postmortem imaging (PMI) including computed tomography (CT) and magnetic resonance imaging (MRI) has become a familiar procedure in forensic casework. We investigated a short term impact of postmortem CT(PM-CT) in routine forensic autopsy cases at our institute during a period of 9 months (n = 121, fetus--92 year-old, 7 h--years postmortem), comparing to autopsy findings. In identification, PM-CT was useful for matching skeletal/dental characteristics, superimposing, and detection of foreign materials. However, conventional X-ray was often more effective for detection of small metallic foreign bodies. In pathomorphology, PM-CT partly demonstrated important findings for determining the immediate cause of death, which were confirmed by autopsy, but interpretation to the underlying/initiating/preceding causes of death or contributory factor(s) was mostly difficult or impossible. However, accumulated PM-CT data were useful for retrospective evaluation and review of autopsy findings. These experiences indicate that PMI is useful for radiographic screening and documentation, to be included in supplementary procedures, employing knowledge and experiences of forensic autopsy.

  4. Myths and misconceptions about medico-legal autopsies among the people of Tamilnadu, India.

    Science.gov (United States)

    Pawar, Mohan N; Suryawanshi, Deodatta M; Kumar, J Praveen

    2015-08-01

    Medico-legal autopsies are conducted as a part of necessary investigation in all unnatural deaths. In India, the awareness about medico-legal autopsies among the population is still at incipient stage. The procedure is largely stigmatised due to various myths and misconceptions. Apprehension about the procedure brings about various emotional reactions of relatives. Hence the study was carried out to know those myths and misconceptions. To find out the various myths and misconceptions about the medico-legal autopsies among the people. To make a lay person aware of the importance of medico-legal autopsies. This is a descriptive cross sectional study conducted in central part of Tamilnadu, India. About 600 participants of age 18 to 80 years were included. Their responses were obtained by semistructured questionnaires. There is a significant difference noted on various views among this population. Administration should strive to rescind these misapprehensions and myths. The medical staff, mass and electronic media should also come forward to educate them. Stipulation of health education about the medico-legal autopsies is must for a lay person. Copyright © 2015 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  5. Workshop for coordinating South Carolina`s pre-college systemic initiatives

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-26

    The goal of the South Carolina Statewide Systemic Initiative (SC SSI) is to provide quality and effective learning experiences in science and mathematics to all people of South Carolina by affecting systemic change. To accomplish this goal, South Carolina must: (1) coordinate actions among many partners for science and mathematics change; (2) place the instruments of change into the hands of the effectors of change - teachers and schools; and (3) galvanize the support of policy makers, parents, and local communities for change. The SC SSI proposes to establish a network of 13 regional mathematics and science HUBs. The central idea of this plan is the accumulation of Teacher Leaders at each HUB who are prepared in special Curriculum Leadership Institutes to assist other teachers and schools. The HUB becomes a regional nexus for delivering services to schools who request assistance by matching schools with Teacher Leaders. Other initiatives such as the use of new student performance assessments, the integration of instructional technologies into the curriculum, a pilot preservice program, and Family Math and Family Science will be bundled together through the Teacher Leaders in the HUBs. Concurrent policy changes at the state level in teacher and administrator certification and recertification requirements, school regulations and accountability, and the student performance assessment system will enable teachers and schools to support instructional practices that model South Carolina`s new state Curriculum Frameworks in Mathematics and Science.

  6. Prevalence of prostate cancer and prostatic intraepithelial neoplasia in Caucasian Mediterranean males: an autopsy study.

    Science.gov (United States)

    Sánchez-Chapado, Manuel; Olmedilla, Gabriel; Cabeza, Manuel; Donat, Emilio; Ruiz, Antonio

    2003-02-15

    The prevalence of carcinoma of the prostate gland (CaP) and high-grade prostatic intraepithelial neoplasia (HGPIN) was assessed in a Spanish population, representative of the Caucasian Mediterranean (CM) ethnic group. Data were compared with those described in populations from other geographical regions and in other ethnic groups. CaP and HGPIN were evaluated in a consecutive series of prostatic glands collected at the post-mortem examination of 162 male patients born and living in Spain, aged 20-80 years, and dying from trauma. The glands were sliced every 2-3 mm. All slices were paraffin embedded and sectioned to obtain 5 microm whole-mount sections. To compare the prevalence rate in our series and in other Caucasian populations with that from other geographical areas and other ethnic groups, we used data from the autopsy study performed at the Wayne State University. Prevalence of CaP is 3.58, 8.82, 14.28, 23.80, 31.7, and 33.33% in the 3rd, 4th, 5th, 6th, 7th, and 8th decades, respectively. The rates of HGPIN were 7.14, 11.75, 35.71, 38.06, 45.40, and 48.15% at the 3rd, 4th, 5th, and 8th decades of life. Both CaP and HGPIN are located preferentially at the peripheral zone of the gland and in 21/27 cases (77.7%), an association between CaP and HGPIN was found. The prevalence of both lesions in CM males is significantly lower than in Caucasian American (CA) and Afro-American (AA) males in all the age groups evaluated. Microscopic foci of CaP and HGPIN can be documented in CM males from the 3rd decade of life onwards. The lesions become more frequent and extensive as age increases. The prevalence of both lesions seems to be significantly lower in the CM population than in CA and AA males in all the age groups evaluated. Copyright 2002 Wiley-Liss, Inc.

  7. Wood Energy Potential in Northwestern South Carolina

    Science.gov (United States)

    James W. McMinn

    1986-01-01

    The quantity of unused wood in an Ill-county area in northwestern South Carolina was projected to be more than 16 million tons annually. Wood that is unsuitable for products other than fuel amounts to nearly 9 million tons annually.The most likely energy demand by industrial plants that are good candidates for wood fuel systems is 1.5 million tons annually.Maximum...

  8. Lost lake - restoration of a Carolina bay

    Energy Technology Data Exchange (ETDEWEB)

    Hanlin, H.G.; McLendon, J.P. [Univ. of South Carolina, Aiken, SC (United States). Dept. of Biology and Geology; Wike, L.D. [Univ. of South Carolina, Aiken, SC (United States). Dept. of Biology and Geology]|[Westinghouse Savannah River Co., Aiken, SC (United States). Savannah River Technology Center; Dietsch, B.M. [Univ. of South Carolina, Aiken, SC (United States). Dept. of Biology and Geology]|[Univ. of Georgia, Aiken, SC (United States)

    1994-09-01

    Carolina bays are shallow wetland depressions found only on the Atlantic Coastal Plain. Although these isolated interstream wetlands support many types of communities, they share the common features of having a sandy margin, a fluctuating water level, an elliptical shape, and a northwest to southeast orientation. Lost Lake, an 11.3 hectare Carolina bay, was ditched and drained for agricultural production before establishment of the Savannah River Site in 1950. Later it received overflow from a seepage basin containing a variety of chemicals, primarily solvents and some heavy metals. In 1990 a plan was developed for the restoration of Lost Lake, and restoration activities were complete by mid-1991. Lost Lake is the first known project designed for the restoration and recovery of a Carolina bay. The bay was divided into eight soil treatment zones, allowing four treatments in duplicate. Each of the eight zones was planted with eight species of native wetland plants. Recolonization of the bay by amphibians and reptiles is being evaluated by using drift fences with pitfall traps and coverboard arrays in each of the treatment zones. Additional drift fences in five upland habitats were also established. Hoop turtle traps, funnel minnow traps, and dip nets were utilized for aquatic sampling. The presence of 43 species common to the region has been documented at Lost Lake. More than one-third of these species show evidence of breeding populations being established. Three species found prior to the restoration activity and a number of species common to undisturbed Carolina bays were not encountered. Colonization by additional species is anticipated as the wetland undergoes further succession.

  9. Through the lens of the clinician: autopsy services and utilization in a large teaching hospital in Ghana.

    Science.gov (United States)

    Yawson, Alfred E; Tette, Edem; Tettey, Yao

    2014-12-23

    Declining hospital autopsy rates in many countries have generated considerable concern. The survey determined challenges of the autopsy service in a large Teaching Hospital in Ghana, from the perspective of clinicians. This was a cross-sectional study of doctors at the Korle-Bu Teaching Hospital (KBTH) over in 2012. The data was collected using a 69 item self-administered structured questionnaire. In all a total of 215 questionnaires were sent out and 119 doctors responded. Data was collected on the challenges of the autopsy services and barriers to autopsy request from the perspectives of clinicians. Survey data were analyzed by simple descriptive statistics (i.e. proportions, ratios and percentages. Data from survey was analyzed with SPSS version 21. The most common reasons for requesting autopsies were to answer clinical questions, 55 (46.2%) and in cases of uncertain diagnosis, 54 (45.4%). Main demand side barriers to the use of autopsy services by clinicians were reluctance of family to give consent for autopsy 100 (84%), due to cultural and religious objections 89 (74.8%), extra funeral cost to family53 (44.5%) and increased duration of stay of body in the morgue 19 (16%). Health system barriers included delayed feedback from autopsy service 54 (45.4%), difficulties following up the autopsy process 40 (33.6%) due to uncertainties in the timing of particular events in the autopsy process, and long waiting time for autopsy reports 81 (68.1%). More than a third of clinicians 43 (36.2%), received full autopsy report beyond three weeks and 75 (63.1%) clinicians had concerns with the validity of reports issued by the autopsy service (i.e. reports lack specificity or at variance with clinical diagnosis, no toxicological, histological or tissue diagnoses are performed). The autopsy service should restructure itself efficiently and management should support the provision of histological and toxicological services. Strengthening internal and external quality

  10. Full body virtual autopsies using a state-of-the-art volume rendering pipeline.

    Science.gov (United States)

    Ljung, Patric; Winskog, Calle; Persson, Anders; Lundström, Claes; Ynnerman, Anders

    2006-01-01

    This paper presents a procedure for virtual autopsies based on interactive 3D visualizations of large scale, high resolution data from CT-scans of human cadavers. The procedure is described using examples from forensic medicine and the added value and future potential of virtual autopsies is shown from a medical and forensic perspective. Based on the technical demands of the procedure state-of-the-art volume rendering techniques are applied and refined to enable real-time, full body virtual autopsies involving gigabyte sized data on standard GPUs. The techniques applied include transfer function based data reduction using level-of-detail selection and multi-resolution rendering techniques. The paper also describes a data management component for large, out-of-core data sets and an extension to the GPU-based raycaster for efficient dual TF rendering. Detailed benchmarks of the pipeline are presented using data sets from forensic cases.

  11. Virtual autopsy and forensic identification-practical application: a report of one case.

    Science.gov (United States)

    Dedouit, Fabrice; Telmon, Norbert; Guilbeau-Frugier, Céline; Gainza, David; Otal, Philippe; Joffre, Francis; Rougé, Daniel

    2007-07-01

    The body of an unidentified elderly woman was found trapped in a floodgate. Prior to autopsy, full-body multislice computed tomography (MSCT) was performed for study of bone lesions and cause of death. Age was estimated by analysis of the sternal end of the fourth rib and of the pubic symphyseal medial articular surfaces. The results were then compared with the autopsy findings. MSCT was superior to autopsy in diagnosis of traumatic bone lesions and also revealed dental anomalies and signs of drowning. Age estimation gave a similar result for both methods. This case report illustrates the potential value of MSCT for medico-legal investigations of death: diagnosis of injuries, possibility of determining the cause of death, and anthropological study in order to estimate age or to visualize features likely to enable identification of a corpse.

  12. Identifying preventable trauma death: does autopsy serve a role in the peer review process?

    Science.gov (United States)

    Scantling, Dane; Teichman, Amanda; Kucejko, Robert; McCracken, Brendan; Eakins, James; Burns, Richard

    2017-07-01

    Missing life-threatening injuries is a persistent concern in any trauma program. Autopsy is a tool routinely utilized to determine an otherwise occult cause of death in many fields of medicine. It has been adopted as a required component of the trauma peer review (PR) process by both the American College of Surgeons and the Pennsylvania Trauma Foundation. We hypothesized that autopsy would not identify preventable deaths for augmentation of the PR process. A retrospective chart review using our institutional trauma registry of all trauma deaths between January 2012 and December 2015 was performed. Per the protocol of our level 1 center, all trauma deaths are referred to the medical examiner (ME) and reviewed as part of the trauma PR process. All autopsy results are evaluated with relation to injury severity score (ISS), trauma injury severity score (TRISS), nature of death, and injuries added by autopsy. ME reports are reviewed by the trauma medical director and referred back to the trauma PR committee if warranted. Trauma injury severity score methodology determines the probability of survival (Ps) given injuries identified. A patient with Ps of ≥0.5 is expected to survive their injuries. Cohorts were created based on when in the hospitalization death occurred: 48 h, or late death. A comparison was conducted between the ISS and Ps calculated during trauma workup and on autopsy using chi-square and Fischer's exact tests. A total of 173 patient deaths were referred to the ME with 123 responses received. Average length of stay was 2.61 d. Twenty-six patients had autopsy declined by the ME, 25 received an external examination only, and 72 received a full autopsy. Autopsy identified one case that was reconsidered in PR (P = 0.603) and added diagnoses, but not injuries, to one patient in the early death group (P = 1) and two in the late death group (P = 0.4921). No preventable cause of death was uncovered, and educational use was minimal. Autopsy did identify

  13. [Soft tissue-cutting law, i.e. the career concept of an autopsy assistant].

    Science.gov (United States)

    Kormos, Timea; Csatai, Tamás; Jäckel, Márta

    2015-03-08

    Practical experience shows that the autopsy assistant society is fairly divided. There are some people who would have needed a thorough basic training, and there are those who - due to their diligence and the close cooperation with physician colleagues - would deserve an opportunity for further progress due to their extensive knowlegde. As regards the autopsy assistant profession the training, and the training system as well has changed significantly, and it requires further changes. Examining the issue in a wide spectrum, the aim of the authors is, as much as possible, to promote the formation of an "Autopsy assistant career," in which they want to create a predictable way for the members of the profession from the phase of becoming a student (competency, training, exams, vocational training, single note) to obtaining the master's degree. The authors would like to provide a summary about their experience and plans regarding this issue.

  14. Sudden unexplained death in childhood. An audit of the quality of Autopsy reporting

    LENUS (Irish Health Repository)

    Treacy, A

    2013-03-01

    Cases of sudden unexplained death in childhood (SUDC) in Ireland in children aged >1year and <5 years were examined in order to assess the quality of autopsy reporting. All SUDC cases are notified to and documented by the National Sudden Infant Death Register (NSIDR) in Ireland along with all cases of sudden infant death syndrome (SIDS) referring to sudden infant deaths less than one year of age. The database of the NSIDR in Ireland was interrogated and cases of SIDS and SUDC were compared over a fifteen-year period (1995-2009). SIDS cases whose autopsies were conducted in the same hospital in the same year as the index SUDC case were used for comparison. The autopsy report for each case was examined and modified Rushton(MR) scores 1\\r\

  15. Hydrologic and water-quality response of forested and agricultural lands during the 1999 extreme weather conditions in Eastern North Carolina

    Science.gov (United States)

    J.D. Shelby; G.M. Chescheir; R.W. Skaggs; D.M. Amatya

    2006-01-01

    This study evaluated hydrologic and water-quality data collected on a coastal-plain research watershed during a series of hurricanes and tropical storms that hit coastal North Carolina in 1999, including hurricanes Dennis, Floyd, and Irene. DU ring September and October 1999, the research watershed received approximately 555 mm of rainfall associated with hurricanes....

  16. 2004-05 Performance Year Ratings Impacting Fiscal Year 2005-06. University of South Carolina Aiken. Sector: Four-Year Colleges and Universities

    Science.gov (United States)

    South Carolina Commission on Higher Education, 2005

    2005-01-01

    This series of documents contains performance scoring information for 2004-2005 for individual institutions of higher education in South Carolina. This information is used in establishing 2005-2006 fiscal year allocations. Data includes: (1) Degrees Awarded; (2) Enrollment; (3) Average SAT score; (4) Faculty; (5) Tuition; and (6) Financial…

  17. Virtual autopsy: preliminary experience in high-velocity gunshot wound victims.

    Science.gov (United States)

    Levy, Angela D; Abbott, Robert M; Mallak, Craig T; Getz, John M; Harcke, H Theodore; Champion, Howard R; Pearse, Lisa A

    2006-08-01

    To retrospectively assess virtual autopsy performed with multidetector computed tomography (CT) for the forensic evaluation of gunshot wound victims. The institutional review board approved this HIPAA-compliant study and did not require informed consent of the next of kin. Thirteen consecutive male gunshot wound victims (mean age, 27 years) were scanned with 16-section multidetector CT prior to routine autopsy. Retrospectively, the total-body nonenhanced scans were interpreted at a three-dimensional workstation by radiologists blinded to autopsy findings. Images were evaluated for lethal wound, number and location of wound tracks, injured structures, and metal fragment location. After image review, autopsy reports and photographs were compared with the images and interpretations to validate the multidetector CT determinations. Multidetector CT aided in correct identification of all lethal wounds, and metallic fragment location was always precise. In four cases, multidetector CT aided in accurate assessment of organ injuries and lethal wounds but led to underestimation of the number of wounds if comingling paths occurred. In two cases of a chest wound, multidetector CT aided in accurate assessment of the chest as having the lethal wound but failed to help identify specific sites of hemorrhage. In two cases of craniofacial injury, the path of the wound was not clear. Autopsy revealed a total of 78 wound tracks (mean, 6; range, 1-24). Ten (13%) wound tracks were not identified at multidetector CT (six upper extremity wounds and four thigh wounds). In two cases, findings missed at autopsy (fracture of the cervical spine, bullet fragments in the posterior area of the neck) were identified at multidetector CT. Multidetector CT can aid prediction of lethal wounds and location of metallic fragments.

  18. Verbal autopsy of 80,000 adult deaths in Tamilnadu, South India

    Directory of Open Access Journals (Sweden)

    Peto Richard

    2004-10-01

    Full Text Available Abstract Background Registration of the fact of death is almost complete in the city of Chennai and not so in the rural Villupuram district in Tamilnadu, India. The cause of death is often inadequately recorded on the death certificate in developing countries like India. A special verbal autopsy (VA study of 48 000 adult (aged ≥ 25 yrs deaths in the city of Chennai (urban during 1995–97 and 32 000 in rural Villupuram during 1997–98 was conducted to arrive at the probable underlying cause of death to estimate cause specific mortality. Methods A ten day training on writing verbal autopsy (VA report for adult deaths was given to non-medical graduates with at least 15 years of formal education. They interviewed surviving spouse/close associates of the deceased to write a verbal autopsy report in local language (Tamil on the complaints, symptoms, signs, duration and treatment details of illness prior to death. Each report was reviewed centrally by two physicians independently. Random re-interviewing of 5% of the VA reports was done to check the reliability and reproducibility of the VA report. The validity of VA diagnosis was assessed only for cancer deaths. Results Verbal autopsy reduced the proportion of deaths attributed to unspecified and unknown causes from 54% to 23% (p Conclusion A ten day training programme to write verbal autopsy report with adequate feed back sessions and random sampling of 5% of the verbal autopsy reports for re-interview worked very well in Tamilnadu, to arrive at the probable underlying cause of death reliably for deaths in early adult life or middle age (25–69 years and less reliably for older ages (70+. Thus VA is practicable for deaths in early adult life or middle age and is of more limited value in old age.

  19. Causes of mortality for Indonesian Hajj Pilgrims: comparison between routine death certificate and verbal autopsy findings.

    Directory of Open Access Journals (Sweden)

    Masdalina Pane

    Full Text Available BACKGROUND: Indonesia provides the largest single source of pilgrims for the Hajj (10%. In the last two decades, mortality rates for Indonesian pilgrims ranged between 200-380 deaths per 100,000 pilgrims over the 10-week Hajj period. Reasons for high mortality are not well understood. In 2008, verbal autopsy was introduced to complement routine death certificates to explore cause of death diagnoses. This study presents the patterns and causes of death for Indonesian pilgrims, and compares routine death certificates to verbal autopsy findings. METHODS: Public health surveillance was conducted by Indonesian public health authorities accompanying pilgrims to Saudi Arabia, with daily reporting of hospitalizations and deaths. Surveillance data from 2008 were analyzed for timing, geographic location and site of death. Percentages for each cause of death category from death certificates were compared to that from verbal autopsy. RESULTS: In 2008, 206,831 Indonesian undertook the Hajj. There were 446 deaths, equivalent to 1,968 deaths per 100,000 pilgrim years. Most pilgrims died in Mecca (68% and Medinah (24%. There was no statistically discernible difference in the total mortality risk for the two pilgrimage routes (Mecca or Medinah first, but the number of deaths peaked earlier for those traveling to Mecca first (p=0.002. Most deaths were due to cardiovascular (66% and respiratory (28% diseases. A greater proportion of deaths were attributed to cardiovascular disease by death certificate compared to the verbal autopsy method (p<0.001. Significantly more deaths had ill-defined cause based on verbal autopsy method (p<0.001. CONCLUSIONS: Despite pre-departure health screening and other medical services, Indonesian pilgrim mortality rates were very high. Correct classification of cause of death is critical for the development of risk mitigation strategies. Since verbal autopsy classified causes of death differently to death certificates, further studies

  20. How can we ensure that the coroner's autopsy is not an invasion of human rights?

    Science.gov (United States)

    Leadbeatter, Stephen; James, Ryk

    2018-01-01

    Despite public inquiries, and some changes to legislation following high-profile multiple homicides that were not detected by autopsy, coroners continue to rely largely on the autopsy. Regardless of the extent of quality failings and excess deaths at some hospitals, not detected through the coroner system, the autopsy is scarcely used by hospitals to monitor standards and educate. To explore when a compulsory medicolegal autopsy should, and should not, be used. Two hundred and thirty-six cases referred to a senior coroner were evaluated by pathologists with long experience of forensic, coronial and hospital autopsies, using detailed antecedent medical and circumstantial information: after their advice, the senior coroner decided what kind of autopsy provided sufficient information for his purposes. In nearly 40% (n=88) of deaths where the senior coroner accepted jurisdiction, issues raised could be resolved through analysis of medical records and antecedent information, supplemented only by detailed external examination of the body. Timely provision of sufficient information allows informed decisions about the requirement for, and nature and extent of, medical investigations into a death: unnecessary post mortem dissection is avoided, protecting the rights, under Articles 8 and 9 of the Human Rights Act 1998, of the bereaved to privacy, family life and religious practice. Although improvements in healthcare can undoubtedly result from detailed coroners' inquiries, those deaths where the matters investigated relate only to the accuracy of a natural cause of death or sit with a healthcare provider's internal quality assurance, should be investigated by the healthcare system in collaboration with the bereaved. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  1. Usefulness of the Population Health Metrics Research Consortium gold standard verbal autopsy data for general verbal autopsy methods.

    Science.gov (United States)

    Byass, Peter

    2014-02-04

    Verbal Autopsy (VA) is widely viewed as the only immediate strategy for registering cause of death in much of Africa and Asia, where routine physician certification of deaths is not widely practiced. VA involves a lay interview with family or friends after a death, to record essential details of the circumstances. These data can then be processed automatically to arrive at standardized cause of death information. The Population Health Metrics Research Consortium (PHMRC) undertook a study at six tertiary hospitals in low- and middle-income countries which documented over 12,000 deaths clinically and subsequently undertook VA interviews. This dataset, now in the public domain, was compared with the WHO 2012 VA standard and the InterVA-4 interpretative model. The PHMRC data covered 70% of the WHO 2012 VA input indicators, and categorized cause of death according to PHMRC definitions. After eliminating some problematic or incomplete records, 11,984 VAs were compared. Some of the PHMRC cause definitions, such as 'preterm delivery', differed substantially from the International Classification of Diseases, version 10 equivalent. There were some appreciable inconsistencies between the hospital and VA data, including 20% of the hospital maternal deaths being described as non-pregnant in the VA data. A high proportion of VA cases (66%) reported respiratory symptoms, but only 18% of assigned hospital causes were respiratory-related. Despite these issues, the concordance correlation coefficient between hospital and InterVA-4 cause of death categories was 0.61. The PHMRC dataset is a valuable reference source for VA methods, but has to be interpreted with care. Inherently inconsistent cases should not be included when using these data to build other VA models. Conversely, models built from these data should be independently evaluated. It is important to distinguish between the internal and external validity of VA models. The effects of using tertiary hospital data, rather than

  2. Diagnostic yield of molecular autopsy in patients with sudden arrhythmic death syndrome using targeted exome sequencing

    DEFF Research Database (Denmark)

    Nunn, Laurence M; Lopes, Luis R; Syrris, Petros

    2016-01-01

    AIMS: The targeted genetic screening of Sudden Arrhythmic Death Syndrome (SADS) probands in a molecular autopsy has a diagnostic yield of up to 35%. Exome sequencing has the potential to improve this yield. The primary aim of this study is to examine the feasibility and diagnostic utility...... of control exomes were prioritized for analysis followed by mutations and 10 probands (17%) had...... previously published rare (0.02-0.5%) candidate mutations-a total yield of 29%. Co-segregation fully confirmed two private SCN5A Na channel mutations. Variants of unknown significance were detected in a further 34% of probands. CONCLUSION: Molecular autopsy using targeted exome sequencing has a relatively...

  3. Amyand's hernia in forensic autopsy: case report and review of the literature.

    Science.gov (United States)

    Türkmen, Nursel; Eren, Bülent; Dokgöz, Halis

    2013-01-01

    The presence of vermiform appendix in inguinal hernia is rare and is known as Amyand's hernia. Reported case was 73 years old man admitted to the hospital with chest pain who dead soon after admittance in the emergency department of the university hospital. In the macroscopic autopsy investigation, after opening the hernial sac, the vermiform appendix and caecum were detected free, without adhesions in the hernial sac. Death was reported due to acute myocardial infarction. Investigation of this rare entity in forensic autopsy is important for scientific classification, description and also correct pre-postoperative management and appropriate surgery.

  4. Geology and geomorphology of the Carolina Sandhills, Chesterfield County, South Carolina

    Science.gov (United States)

    Swezey, Christopher; Fitzwater, Bradley A.; Whittecar, G. Richard

    2016-01-01

    This two-day field trip focuses on the geology and geomorphology of the Carolina Sandhills in Chesterfield County, South Carolina. This area is located in the updip portion of the U.S. Atlantic Coastal Plain province, supports an ecosystem of longleaf pine (Pinus palustris) and wiregrass (Aristida stricta), and contains three major geologic map units: (1) An ~60–120-m-thick unit of weakly consolidated sand, sandstone, mud, and gravel is mapped as the Upper Cretaceous Middendorf Formation and is interpreted as a fluvial deposit. This unit

  5. Carrboro, North Carolina: Achieving Building Efficiencies for Low-Income Households (City Energy: From Data to Decisions)

    Energy Technology Data Exchange (ETDEWEB)

    Office of Strategic Programs, Strategic Priorities and Impact Analysis Team

    2017-09-29

    This fact sheet "Carrboro, North Carolina: Achieving Building Efficiencies for Low-Income Households" explains how the Town of Carrboro used data from the U.S. Department of Energy's Cities Leading through Energy Analysis and Planning (Cities-LEAP) and the State and Local Energy Data (SLED) programs to inform its city energy planning. It is one of ten fact sheets in the "City Energy: From Data to Decisions" series.

  6. SERIES ARTICLES

    Indian Academy of Sciences (India)

    An artistic 'representation' of biological clocks. ( Credit: Subhankar Biswas ). M K Chandrashekaran. (1937–2009). ( Illustration: Subhankar Biswas ). Front Cover. Back Cover. 701. Science Smiles. Ayan Guha. 704. Inside Back Cover. Flowering Trees. (Credit: K Sankara Rao, IISc). SERIES ARTICLES. 770 Dawn of Science.

  7. SERIES ARTICLES

    Indian Academy of Sciences (India)

    Resonance journal of science education. February 2012 Volume 17 Number 2. SERIES ARTICLES. 106 Dawn of Science. Calculus is Developed in Kerala. T Padmanabhan. GENERAL ARTICLES. 117 Willis H Carrier: Father of Air Conditioning. R V Simha. 139 Refrigerants For Vapour Compression Refrigeration. Systems.

  8. Fourier Series

    Indian Academy of Sciences (India)

    GENERAL I ARTICLE. Fourier Series. The Mathematics of Periodic Phenomena. The author received his. Ph.D from Princeton. University in 1987. After spending several years at. TIFR Centre, Bangalore, he is currently with the. Indian Statistical Institute,. Bangalore. His research interests are in harmonic analysis and partial.

  9. Case Series

    African Journals Online (AJOL)

    Abstract. Introduction: Hemodialysis (HD) patients are predisposed to infective endocarditis (IE) mainly due to repeated manipulation of the vascular access. However, catheter seeding and IE may also result from a distant infection site. Case series: A diabetic patient who was maintained on regular HD through a permanent ...

  10. [Creating language model of the forensic medicine domain for developing a autopsy recording system by automatic speech recognition].

    Science.gov (United States)

    Niijima, H; Ito, N; Ogino, S; Takatori, T; Iwase, H; Kobayashi, M

    2000-11-01

    For the purpose of practical use of speech recognition technology for recording of forensic autopsy, a language model of the speech recording system, specialized for the forensic autopsy, was developed. The language model for the forensic autopsy by applying 3-gram model was created, and an acoustic model for Japanese speech recognition by Hidden Markov Model in addition to the above were utilized to customize the speech recognition engine for forensic autopsy. A forensic vocabulary set of over 10,000 words was compiled and some 300,000 sentence patterns were made to create the forensic language model, then properly mixing with a general language model to attain high exactitude. When tried by dictating autopsy findings, this speech recognition system was proved to be about 95% of recognition rate that seems to have reached to the practical usability in view of speech recognition software, though there remains rooms for improving its hardware and application-layer software.

  11. The Chemical Adventures of Sherlock Holmes: Autopsy in Blue

    Science.gov (United States)

    Waddell, Thomas G.; Rybolt, Thomas R.

    2004-04-01

    This story is a chemical mystery with an emphasis on qualitative inorganic analysis, forensic chemistry, and medicinal substances. This is the 15th article in a series presenting a scientific problem in mystery format in the context of the popular and beloved characters Sherlock Holmes and Dr. Watson. There is a break in the story where readers (students and teachers) can ponder and solve the mystery. Sherlock Holmes provides his solution in the paragraphs following this break.

  12. Case series

    African Journals Online (AJOL)

    raoul

    3 mars 2011 ... Published in partnership with the African Field Epidemiology Network (AFENET). (www.afenet.net). Case series. Open Access ... L'analyse statistique a été réalisée en utilisant le programme statistique pour les sciences sociales (SPSS) version13. .... données nécessaires pour la réalisation de ce travail.

  13. Exposures series

    OpenAIRE

    Stimson, Blake

    2011-01-01

    Reaktion Books’ Exposures series, edited by Peter Hamilton and Mark Haworth-Booth, is comprised of 13 volumes and counting, each less than 200 pages with 80 high-quality illustrations in color and black and white. Currently available titles include Photography and Australia, Photography and Spirit, Photography and Cinema, Photography and Literature, Photography and Flight, Photography and Egypt, Photography and Science, Photography and Africa, Photography and Italy, Photography and the USA, P...

  14. Accessibility and Usage of Technology by North Carolina Agriculture Teachers

    Science.gov (United States)

    Williams, Maegen R.; Warner, Wendy J.; Flowers, James L.; Croom, D. Barry

    2014-01-01

    This study examined the integration of technology into the instructional process in North Carolina agricultural education classrooms. The study used survey research methodology to collect information on the availability of instructional technology and the frequency of instructional technology use by North Carolina agriculture teachers. The study…

  15. Terrapene carolina triunguis (three-toed box turtle)

    Science.gov (United States)

    Cory K. Adams; Jennifer H. Adams

    2013-01-01

    Terrapene carolina triunguis is the western-most subspecies of T. carolina and has a range that stretches from southeast Kansas and central Missouri south to the Gulf Coast (Conant and Collins 1998. A Field Guide to Reptiles and Amphibians of Eastern and Central North America. 3rd ed. Houghton Mifflin Co., Boston, Massachusetts....

  16. Demonstrating the Collective Economic Value of North Carolina Community Colleges

    Science.gov (United States)

    North Carolina Community College System, 2015

    2015-01-01

    The purpose of this report is to assess the collective impact of North Carolina Community Colleges on the state economy and the benefits generated by the colleges for students, society, and taxpayers. The results of this study show that North Carolina Community Colleges create a positive net impact on the state economy and generate a positive…

  17. Trends in Infant Mortality, North Carolina: 1940 to 1970.

    Science.gov (United States)

    Brannon, Yevonne S.; Clifford, William B.

    This report presents data analyzed by county and multicounty planning region which indicate that North Carolina's infant mortality rate has declined by 59 percent since 1940. (In 1940, approximately 58 infants for every 1,000 live births died in North Carolina before their first birthday.) This reduction in infant deaths is comparable to that…

  18. Autopsy practice in forensic pathology - Evidence-based or experience-based?

    DEFF Research Database (Denmark)

    Colville-Ebeling, Bonnie; Freeman, Michael; Banner, Jytte

    2014-01-01

    Current autopsy practice in forensic pathology is to a large extent based on experience and individual customary practices as opposed to evidence and consensus based practices. As a result there is the potential for substantial variation in how knowledge is applied in each case. In the present ca...

  19. [Autopsies in Switzerland, Germany and Austria: considerations about legal facts and the current situation].

    Science.gov (United States)

    Tag, B

    2011-11-01

    Significant reasons militate for the implementation of clinical autopsies: On the part of physicians and nurses, there is quality assurance, establishment of legal certainty regarding possible accusations of medical errors and development of treatment methods. On the part of patients and their relatives, there is consolation and relief in cases of unexpected death, insight into genetic dispositions and insurance law concerns, to name only a few. However, a continuing decrease of clinical autopsies can be observed in Switzerland, Germany and Austria. The thesis asserting that the often required informed consent of the deceased during his/her lifetime or of close relatives is a crucial reason for this decrease needs to be called into question due to recent studies. Mainsprings are rather structural reasons, such as the often deficient communication with the patient or close relatives, economic reasons, namely the frequently insufficient remuneration for the clinical autopsy, organizational causes, in particular the repeatedly encountered suboptimal collaboration between the individual departments and the pathology department, the high administrative effort and probably the decreasing appreciation of the clinical autopsy.

  20. Problems with the use of autopsy results as a yardstick in medical audit and epidemiology.

    Science.gov (United States)

    Saracci, R

    1993-12-01

    Autopsy can represent a key instrument in auditing clinical diagnosis performance, on which in turn the accuracy of diagnoses, as used in a variety of epidemiological investigations, depend. This audit can be implemented through clinico-pathological surveys which require both accurate pathological examinations and validity of study design and analysis. To this end, estimates of sensitivity and specificity of the clinical diagnosis, using the autopsy diagnosis as a yardstick, should be obtained, which can however be severely distorted by factors such as nonrandom selection of cases for autopsy or by unrecognized errors in post-mortem diagnosis. Such distortion may be minimized by (a) estimating the likely magnitude of errors in postmortem diagnosis, (b) specifying standard conditions for performing autopsies and (c) ensuring an unbiased sample of moderate size rather than a large biased sample. Considerable improvement in the validity of clinico-pathological surveys as carried out up until now is possible, and there is room for research to provide the necessary information (e.g. on necropsy diagnosis variability and feasible sampling schemes).

  1. Perinatal mortality: clinical value of postmortem magnetic resonance imaging compared with autopsy in routine obstetric practice

    NARCIS (Netherlands)

    Alderliesten, Marianne E.; Peringa, Jan; van der Hulst, Victor P. M.; Blaauwgeers, Hans L. G.; van Lith, Jan M. M.

    2003-01-01

    Objective To compare postmortem magnetic resonance imaging (MRI) with autopsy in perinatal deaths. To determine the acceptance and feasibility of postmortem perinatal MRI. Design Cohort study. Setting Large teaching hospital. Population Fetuses and neonates from 16 weeks gestational age until 28

  2. An erroneous opinion on a cause of death in a forensic autopsy: a ...

    African Journals Online (AJOL)

    Background: The quality of autopsies is always questioned in courts, especially in developing countries. Wrong decisions or misjudgments are undesirable in medicine, but they are very dangerous in forensic medicine. If a wrong opinion is given, either a culprit can be acquitted or an innocent person can be sentenced.

  3. Autopsy interrogation of emergency medicine dispute cases: how often are clinical diagnoses incorrect?

    Science.gov (United States)

    Liu, Danyang; Gan, Rongchang; Zhang, Weidi; Wang, Wei; Saiyin, Hexige; Zeng, Wenjiao; Liu, Guoyuan

    2018-01-01

    Emergency medicine is a 'high risk' specialty. Some diseases develop suddenly and progress rapidly, and sudden unexpected deaths in the emergency department (ED) may cause medical disputes. We aimed to assess discrepancies between antemortem clinical diagnoses and postmortem autopsy findings concerning emergency medicine dispute cases and to figure out the most common major missed diagnoses. Clinical files and autopsy reports were retrospectively analysed and interpreted. Discrepancies between clinical diagnoses and autopsy diagnoses were evaluated using modified Goldman classification as major and minor discrepancy. The difference between diagnosis groups was compared with Pearson χ2 test. Of the 117 cases included in this study, 71 of cases (58 class I and 13 class II diagnostic errors) were revealed as major discrepancies (60.7%). The most common major diagnoses were cardiovascular diseases (54 cases), followed by pulmonary diseases, infectious diseases and so on. The difference of major discrepancy between the diagnoses groups was significant (pclinical diagnoses and postmortem examinations exist in emergency medical disputes cases; acute aortic dissection and myocardial infarction are the most frequently major missed diagnoses that ED clinicians should pay special attention to in practice. This study reaffirmed the necessity and usefulness of autopsy in auditing death in EDs. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  4. Quantification of neuropathological findings by image data for the diagnosis of dementia in forensic autopsy cases.

    Science.gov (United States)

    Takayama, Mio; Kashiwagi, Masayuki; Matsusue, Aya; Waters, Brian; Hara, Kenji; Ikematsu, Natsuki; Kubo, Shin-ichi

    2016-01-01

    The aim of the present study was to quantify neuropathological findings using image analysis software for the diagnosis of dementia in deceased who underwent forensic autopsy. Of the autopsies performed within 48 hours of death and excluding those of patients with head injury, thermal injury, heat stroke, or intracranial lesions, 8 were of autopsy cases clinically diagnosed with dementia and thus included in the dementia group (D). The non-dementia group (non-D) consisted of 6 deceased without dementia. To compare the D and non-D groups, 6 regions and 7 types of pathological findings were observed semi-quantitatively using 4 conventional stainings. Quantitative analysis of collected image data was performed using image analysis software. Semiquantitative analysis of senile plaques and neurofibrillary tangles was performed with Bielschowsky-Hirano's silver staining image data. An easy, simple, and effective quantification method of the pathological findings was achieved. However, no significant differences were observed between the two groups, and diagnosis of dementia by the quantification of pathological findings was not successful. Diagnosis of dementia using image data may be possible in future studies with an increased number of autopsies, and by utilizing staining techniques with higher specificity and sensitivity, such as immunohistochemical staining.

  5. Nearly All Autopsied NFL Players Show Trauma-Linked Brain Disease

    Science.gov (United States)

    ... back for the New York Giants. The new study results were published July 25 in the Journal of ... Because of the limitations of an autopsy-based study, we really don't know ... contact sports," Rabinovici said. While new methods for CTE diagnosis ...

  6. Correlation between prenatal diagnosis by ultrasound and fetal autopsy findings in second-trimester abortions

    DEFF Research Database (Denmark)

    Hauerberg, Laura; Skibsted, Lillian; Graem, Niels

    2012-01-01

    We evaluated the correlation between prenatal diagnosis by ultrasound and autopsy findings, based on 52 second-trimester pregnancies terminated due to fetal malformations or chromosome aberrations diagnosed at a gestational age of 12-25 weeks. In 24 pregnancies, there was full agreement between u...... shows the value and benefit of postmortem fetal examination following termination of a pregnancy....

  7. Psychosocial and Psychiatric Factors Associated with Adolescent Suicide: A Case-Control Psychological Autopsy Study

    Science.gov (United States)

    Portzky, Gwendolyn; Audenaert, Kurt; van Heeringen, Kees

    2009-01-01

    This study aimed at the investigation of psychosocial and psychiatric risk factors of adolescent suicide by means of a case-control psychological autopsy study. Relatives and other informants of 19 suicide victims and 19 matched psychiatric controls were interviewed by means of a semi-structured interview schedule. Psychiatric controls included…

  8. Anaerobiospirillum succiniciproducens sepsis in an autopsy patient: A troublesome diagnostic workup

    Directory of Open Access Journals (Sweden)

    Jason Koshy

    2014-01-01

    Full Text Available Anaerobiospirillum succiniciproducens is an uncommon yet potentially lethal gram-negative bacterium typically affecting patients with comorbidities. We report a case of A. succiniciproducens infection in an autopsy patient who had hepatitis C and type 2 diabetes and describe the difficulties in the laboratory identification of this pathogen.

  9. The importance of microbiological testing for establishing cause of death in 42 forensic autopsies

    DEFF Research Database (Denmark)

    Christoffersen, Søren

    2015-01-01

    postmortem. With this study we aim to review the use of microbiological procedures at our forensic institute. In a retrospective study including 42 autopsies performed at our Institute, where microbiological test had been applied, analyses were made with regard to: type of microbiological tests performed...

  10. Cardiovascular Damage in Alzheimer Disease: Autopsy Findings From the Bryan ADRC

    Directory of Open Access Journals (Sweden)

    Elizabeth H. Corder

    2005-01-01

    associated with the APOEε4. Instead, autopsy findings of extensive atherosclerosis were associated with possible, not probable or definite AD, and premature death. They are consistent with the hypothesis that brain hypoperfusion contributes to dementia, possibly to AD pathogenesis, and raise the possibility that the APOE allele ε4 contributes directly to heart valve and myocardial damage.

  11. A Psychological Autopsy of the Suicide of an Academically Gifted Student: Researchers' and Parents' Perspectives.

    Science.gov (United States)

    Cross, Tracy L.; Gust-Brey, Karyn; Ball, P. Bonny

    2002-01-01

    A case study of an academically gifted college student who committed suicide resulted in three sets of findings: those that reflected exclusively on the subject's life, those that compared his life with 3 previous psychological autopsies conducted, and those that reflected the parents' observations and experiences of his life. (Contains…

  12. 78 FR 38735 - Autopsy Performance Criteria: Standards, Guidelines and Best Practices

    Science.gov (United States)

    2013-06-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Office of Justice Programs Autopsy Performance Criteria: Standards, Guidelines and Best Practices AGENCY... and Best Practices''. The opportunity to provide comments on this document is open to coroner/medical...

  13. Severe Fat Accumulation in Multiple Organs in Pediatric Autopsies: An Uncommon but Significant Finding

    NARCIS (Netherlands)

    Bleeker, Jeannette C.; Visser, Gepke; Wijburg, Frits A.; Ferdinandusse, Sacha; Waterham, Hans R.; Nikkels, Peter G. J.

    2017-01-01

    Background: The observation of fat accumulation in different organs at pediatric autopsy may help determine the cause of death. However, a comprehensive study on fat accumulation and related etiologies is still lacking. Aim: To investigate the incidence of fat accumulation in different organs in

  14. Severe fat accumulation in multiple organs in pediatric autopsies : An uncommon but significant finding

    NARCIS (Netherlands)

    Bleeker, Jeannette C.; Visser, Gepke; Wijburg, Frits A.; Ferdinandusse, Sacha; Rwaterham, Hans; Nikkels, Peter G.J.

    2017-01-01

    Background: The observation of fat accumulation in different organs at pediatric autopsy may help determine the cause of death. However, a comprehensive study on fat accumulation and related etiologies is still lacking. Aim: To investigate the incidence of fat accumulation in different organs in

  15. Resuscitation complications encountered in forensic autopsy cases performed in Muğla province.

    Science.gov (United States)

    Beydilli, Halil; Balcı, Yasemin; Işık, Şahin; Erbaş, Melike; Acar, Ethem; Savran, Bülent

    2015-12-01

    The purpose of this study was to determine complications of resuscitation seen during autopsies and evaluate the effectiveness of basic life support training. Autopsy case reports conducted in The Forensic Branch Manager of Muğla were retrospectively examined. Demographic data of the patients with resuscitation complications such as age, gender, manner of death, and kinds and features of the complications were recorded. In total, seventy-fourof the 100 cases with resuscitation complications were males. The autopsies in most of these cases were performed during the summer season. Among the patients, 68% died for non-traumatic reasons. Rib fractures were detected in seventy-one patients and sternum fractures in thirty-two patients. Moreover, damage to the pericardium (2%) and lung parenchymal (4%), heart lesions (4%), and liver lacerations (2%) were detected. Regarding rib fractures, fractures were found between the first and eighth ribs on both sides, with the highest numbers occurring in the fourth rib. Resuscitation complications are important since they can be presumed to have carried out for traumatic reasons.Resuscitation complications seen in autopsy cases with non-traumatic causes can be perceived as traumatic events. They can be assumed incorrectly as trauma symptoms. These complications can be reduced with a good resuscitation training of the health personnel.

  16. Hiding in Plain Sight: Clinically Unrecognized Fatal Tooth Asphyxia Revealed by the Forensic Autopsy.

    Science.gov (United States)

    Armstrong, Erica J

    2016-03-01

    Fatal asphyxia by choking whether by food or foreign material remains an uncommon occurrence affecting mainly those at the extremes of age and with variable and sometimes misleading clinical presentations. Prompt clinical recognition of impending airway obstruction afforded by complete physical examination and assessment is paramount for prevention of morbidity and mortality in these cases. In the elderly, a death initially presenting with sudden cardiorespiratory collapse may be erroneously certified as due to natural disease without performance of an autopsy. Fortunately, deaths subsequent to cardiorespiratory collapse, where results of the clinical work-up fail to identify an etiology and medical history is insufficient, are reportable, falling under the jurisdiction of the medical examiner/coroner. The performance of an autopsy in the evaluation of a sudden death arising after hospitalization in which the etiology remains unclear can provide valuable information to our clinical colleagues that they can apply to more timely diagnosis and treatment. Furthermore, the forensic autopsy offers clarification and answers to questions of medicolegal importance. This is particularly true for choking deaths. Presented is a choking death after tooth aspiration whereby the forensic autopsy provided specific anatomic correlation to the clinical clues not recognized before death and provided the true cause of death.

  17. Physics Education Reform: An Object Lesson from Coastal Carolina University

    Science.gov (United States)

    Keiner, Louis

    2007-11-01

    During the last two decades, researches from both the physics education research (PER) community and the cognitive sciences have determined that physics is best learned in an interactive environment where students are actively engaged in their learning. Despite this most introductory physics classes taught at American universities use pedagogical techniques that are still traditional passive lectures. It is not surprising that both student enthusiasm and student performance are generally quite low. In this talk, we will review the outcomes of PER research, and discuss our adaptation of these findings to our physics classrooms. In particular, at Coastal Carolina University, we have implemented the SCALE-UP model of Physics instruction. This model combines lecture and laboratory into single entity, emphasizes active learning, and student cooperation. It uses applications of technology including web-based quizzes and homework, online demonstrations, interactive computer simulations, video analysis, data time-series analysis and computer/instrument interfacing. We have seen a major impact on both student grades and performance on standardized tests. In this presentation, we will illustrate the SCALE-UP model and report on its positive impact on students.

  18. [Sudden death during sport activity in Tunisia: autopsy study in 32 cases].

    Science.gov (United States)

    Allouche, M; Boudriga, N; Ahmed, H Ben; Banasr, A; Shimi, M; Gloulou, F; Zhioua, M; Bouhajja, B; Baccar, H; Hamdoun, M

    2013-04-01

    To develop profile of the victims and to study circumstances, causes of death and autopsy findings. Retrospective study of cases of sudden death in sport activity whose autopsy was performed in forensic department of Tunis, between January 2005 and December 2009. During study period, 32 cases of SD in sport activity were recorded. These are amateur athletes predominantly male (84% of cases). Victims are aged between 15 and 79 years with an average age of about 33.16 years. Young subjects whose age is less than 35 years representing 68.7% of cases. 9.3% of victims had a family history of SD and 18.7% of cases had a known cardiac history. The sports most involved are running (40.6% of cases), football (31.3% of cases) and dance (12.5% of cases). Sixty-nine percent of victims died during sports activities. Presence of witnesses was noted in all cases; however, none of these witnesses has begun resuscitation. Cause of death was cardiac in 84.4% of cases. In young athletes, hypertrophic cardiomyopathy is the leading cause (nine cases), followed by arrhythmogenic right ventricular dysplasia (three cases). Among other causes, there is the myocardial bridge, congenital anomalies of the coronary arteries, aortic dissection and dilated cardiomyopathy. Beyond 35 years, coronary artery diseases represent the cause of death (nine cases). Only case of death secondary to non-cardiac disease occurred after a severe asthma attack. In four cases (12.5%), no cause of death was identified after a complete autopsy accompanied by further investigations. The cause of the death was imputed to a rhythmic pathology. This is the first study dealing with autopsy in SD in sport have provided a specific profile of victims. Other studies on larger samples and using standardized autopsy protocols are needed. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  19. Quantification of interstitial fluid on whole body CT: comparison with whole body autopsy.

    Science.gov (United States)

    Lo Gullo, Roberto; Mishra, Shelly; Lira, Diego A; Padole, Atul; Otrakji, Alexi; Khawaja, Ranish Deedar Ali; Pourjabbar, Sarvenaz; Singh, Sarabjeet; Shepard, Jo-Anne O; Digumarthy, Subba R; Kalra, Mannudeep K; Stone, James R

    2015-12-01

    Interstitial fluid accumulation can occur in pleural, pericardial, and peritoneal spaces, and subcutaneous tissue planes. The purpose of the study was to assess if whole body CT examination in a postmortem setting could help determine the presence and severity of third space fluid accumulation in the body. Our study included 41 human cadavers (mean age 61 years, 25 males and 16 females) who had whole-body postmortem CT prior to autopsy. All bodies were maintained in the morgue in the time interval between death and autopsy. Two radiologists reviewed the whole-body CT examinations independently to grade third space fluid in the pleura, pericardium, peritoneum, and subcutaneous space using a 5-point grading system. Qualitative CT grading for third space fluid was correlated with the amount of fluid found on autopsy and the quantitative CT fluid volume, estimated using a dedicated software program (Volume, Syngo Explorer, Siemens Healthcare). Moderate and severe peripheral edema was seen in 16/41 and 7/41 cadavers respectively. It is not possible to quantify anasarca at autopsy. Correlation between imaging data for third space fluid and the quantity of fluid found during autopsy was 0.83 for pleural effusion, 0.4 for pericardial effusion and 0.9 for ascites. The degree of anasarca was significantly correlated with the severity of ascites (p < 0.0001) but not with pleural or pericardial effusion. There was strong correlation between volumetric estimation and qualitative grading for anasarca (p < 0.0001) and pleural effusion (p < 0.0001). Postmortem CT can help in accurate detection and quantification of third space fluid accumulation. The quantity of ascitic fluid on postmortem CT can predict the extent of anasarca.

  20. Medical malpractice as reflected by the forensic evaluation of 4450 autopsies.

    Science.gov (United States)

    Madea, Burkhard; Preuss, Johanna

    2009-09-10

    A multicentre retrospective analysis of 4450 autopsies carried out due to suspicion of medical malpractice in 17 German institutes of forensic medicine from 1990 to 2000 was performed for the German Federal Ministry of Health. During the time period analysed an increase of cases could be mentioned. The main results of the study are: in the cooperating institutes the total number of autopsies due to suspected medical malpractice ranged from 1.4 to 20%. In more than 40% of the cases preliminary proceedings were started because the manner of death was certified as non-natural or not clarified. Hospital doctors were more affected by medical malpractice claims than doctors in private practice. However, the number of confirmed cases of medical malpractice was higher for doctors in private practice than for hospital doctors. Although surgery is still at the top of the disciplines involved in medical malpractice claims the number of confirmed surgical cases was below the average. Mistakes in care were confirmed to be above the average. Medico-legal autopsies are still a very sufficient method to evaluate cases of medical malpractice: 2863 cases could already be clarified by autopsy. Up to now there is no systematic registration of medical malpractice charges in Germany. A systematic registration should be initiated to build up and/or improve error reporting systems and, thus, to improve patient safety. Compared to other sources of medical malpractice claims (arbitration committees of the medical chambers, reference material of health and insurance companies, files of civil courts) the data of the present multicentre study are in so far unique as only lethal cases were evaluated and a complete autopsy report was available as basis of an expert opinion in alleged medical malpractice cases.

  1. Post-mortem forensic neuroimaging: correlation of MSCT and MRI findings with autopsy results.

    Science.gov (United States)

    Yen, Kathrin; Lövblad, Karl-Olof; Scheurer, Eva; Ozdoba, Christoph; Thali, Michael J; Aghayev, Emin; Jackowski, Christian; Anon, Javier; Frickey, Nathalie; Zwygart, Karin; Weis, Joachim; Dirnhofer, Richard

    2007-11-15

    Multislice-computed tomography (MSCT) and magnetic resonance imaging (MRI) are increasingly used for forensic purposes. Based on broad experience in clinical neuroimaging, post-mortem MSCT and MRI were performed in 57 forensic cases with the goal to evaluate the radiological methods concerning their usability for forensic head and brain examination. An experienced clinical radiologist evaluated the imaging data. The results were compared to the autopsy findings that served as the gold standard with regard to common forensic neurotrauma findings such as skull fractures, soft tissue lesions of the scalp, various forms of intracranial hemorrhage or signs of increased brain pressure. The sensitivity of the imaging methods ranged from 100% (e.g., heat-induced alterations, intracranial gas) to zero (e.g., mediobasal impression marks as a sign of increased brain pressure, plaques jaunes). The agreement between MRI and CT was 69%. The radiological methods prevalently failed in the detection of lesions smaller than 3mm of size, whereas they were generally satisfactory concerning the evaluation of intracranial hemorrhage. Due to its advanced 2D and 3D post-processing possibilities, CT in particular possessed certain advantages in comparison with autopsy with regard to forensic reconstruction. MRI showed forensically relevant findings not seen during autopsy in several cases. The partly limited sensitivity of imaging that was observed in this retrospective study was based on several factors: besides general technical limitations it became apparent that clinical radiologists require a sound basic forensic background in order to detect specific signs. Focused teaching sessions will be essential to improve the outcome in future examinations. On the other hand, the autopsy protocols should be further standardized to allow an exact comparison of imaging and autopsy data. In consideration of these facts, MRI and CT have the power to play an important role in future forensic

  2. Three Decades of Silicosis: Disease Trends at Autopsy in South African Gold Miners

    Science.gov (United States)

    Nelson, Gill; Girdler-Brown, Brendan; Ndlovu, Ntombizodwa; Murray, Jill

    2010-01-01

    Background Eliminating silicosis is a priority of the International Labour Organization and the World Health Organization. Prevalence is particularly high in developing countries. Objectives We describe trends in silicosis among South African gold miners who had had an autopsy between 1975 and 2007 and quantify the contributions of age at autopsy and employment duration to these trends. Methods South African miners and ex-miners are eligible for autopsy examination for occupational lung disease, regardless of the clinical cause of death, and the families of deceased mine workers may receive compensation from the government of South Africa. Miners who died from external causes and who had been employed in the gold mines for > 1 year were stratified by population group because of differences in exposure, patterns of employment, and autopsy referral patterns. We extracted data from PATHAUT (Pathology Automation System) and used Stata 10 to estimate trends in relative proportions of silicosis that were standardized for age and employment duration. Results The crude proportion of silicosis for white miners was six times that of black miners in 1975. By 2007, it was 1.5 times higher for black miners. The proportion of miners with silicosis increased from 0.03 to 0.32 for black miners and from 0.18 to 0.22 for white miners. The increase can be explained by increasing age and employment duration for white miners. For black miners, it can be only partly explained by these two factors. Conclusion As miners continue to age and work for longer periods, the burden of silicosis will continue to rise. South Africa is committed to global efforts to eliminate silicosis by 2030. The autopsy database allows for disease surveillance, which is necessary to monitor the success of this initiative. PMID:20194070

  3. Analysis of Health Facility Based Perinatal Verbal Autopsy of Electoral Constituency 2 of Arghakhanchi District, Nepal.

    Science.gov (United States)

    Manandhar, S R; Manandhar, D S; Adhikari, D; Shrestha, J; Rai, C; Rana, H; Paudel, M

    2015-01-01

    Verbal autopsy is a method to diagnose possible cause of death by analyzing factors associated with death through detailed questioning. This study is a part of the operational research program in electoral constituency no. 2 (EC 2) of Arghakhanchi district by MIRA and HealthRight International. Two day essential newborn care training followed by one day perinatal verbal autopsy training and later one day refresher verbal autopsy training was given for health staff of EC 2 of Arghakhanchi district in two groups. Stillbirths of >22wks or > 500 gms and Early neonatal deaths (newborns died within7 days of life) were included in this study. The Nepal Government approved verbal autopsy forms were used for performing autopsies. Perinatal deaths were classified according to Wigglesworth's Classification. Causes of Perinatal deaths were analyzed. Data were analyzed in the form of frequencies and tabulation in SPSS 16 . There were 41 cases of perinatal deaths (PND) were identified. Among them, 37 PNDs were from Arghakhanchi district hospital, 2 PNDs from Thada PHC, and one PND each from Subarnakhal and Pokharathok HPs. Among the 41 PNDs, 26 were stillbirths (SB) and 15 were early neonatal deaths (ENND). The perinatal mortality rate (PMR) of Arghakhanchi district hospital was 32.2 per 1,000 births and neonatal mortality rate (NMR) was 9.8 per 1,000 live births. Out of 26 stillbirths, 54% (14) were fresh SBs and 46% (12) were macerated stillbirths. The most common cause of stillbirth was obstetric complications (47%) where as birth asphyxia (53%) was the commonest cause of ENND. According to Wigglesworth's classification of perinatal deaths, Group IV (40%) was the commonest cause in the health facilities. Obstetric complication was the commonest cause of stillbirth and birth asphyxia was the commonest cause of early neonatal death. This study highlighted the need for regular antenatal check-ups and proper intrapartum fetal monitoring with timely and appropriate intervention to

  4. Causes of mortality for Indonesian Hajj Pilgrims: comparison between routine death certificate and verbal autopsy findings.

    Science.gov (United States)

    Pane, Masdalina; Imari, Sholah; Alwi, Qomariah; Nyoman Kandun, I; Cook, Alex R; Samaan, Gina

    2013-01-01

    Indonesia provides the largest single source of pilgrims for the Hajj (10%). In the last two decades, mortality rates for Indonesian pilgrims ranged between 200-380 deaths per 100,000 pilgrims over the 10-week Hajj period. Reasons for high mortality are not well understood. In 2008, verbal autopsy was introduced to complement routine death certificates to explore cause of death diagnoses. This study presents the patterns and causes of death for Indonesian pilgrims, and compares routine death certificates to verbal autopsy findings. Public health surveillance was conducted by Indonesian public health authorities accompanying pilgrims to Saudi Arabia, with daily reporting of hospitalizations and deaths. Surveillance data from 2008 were analyzed for timing, geographic location and site of death. Percentages for each cause of death category from death certificates were compared to that from verbal autopsy. In 2008, 206,831 Indonesian undertook the Hajj. There were 446 deaths, equivalent to 1,968 deaths per 100,000 pilgrim years. Most pilgrims died in Mecca (68%) and Medinah (24%). There was no statistically discernible difference in the total mortality risk for the two pilgrimage routes (Mecca or Medinah first), but the number of deaths peaked earlier for those traveling to Mecca first (p=0.002). Most deaths were due to cardiovascular (66%) and respiratory (28%) diseases. A greater proportion of deaths were attributed to cardiovascular disease by death certificate compared to the verbal autopsy method (ppilgrim mortality rates were very high. Correct classification of cause of death is critical for the development of risk mitigation strategies. Since verbal autopsy classified causes of death differently to death certificates, further studies are needed to assess the method's utility in this setting.

  5. Modeling the climatic and subsurface stratigraphy controls on the hydrology of a Carolina Bay wetland in South Carolina, USA

    Science.gov (United States)

    Ge Sun; Timothy J. Callahan; Jennifer E. Pyzoha; Carl C. Trettin

    2006-01-01

    Restoring depressional wetlands or geographically isolated wetlands such as cypress swamps and Carolina bays on the Atlantic Coastal Plains requires a clear understanding of the hydrologic processes and water balances. The objectives of this paper are to (1) test a distributed forest hydrology model, FLATWOODS, for a Carolina bay wetland system using seven years of...

  6. A conceptual hydrologic model for a forested Carolina bay depressional wetland on the Coastal Plain of South Carolina, USA

    Science.gov (United States)

    Jennifer E. Pyzoha; Timothy J. Callahan; Ge Sun; Carl C. Trettin; Masato Miwa

    2008-01-01

    This paper describes how climate influences the hydrology of an ephemeral depressional wetland. Surface water and groundwater elevation data were collected for 7 years in a Coastal Plain watershed in South Carolina USA containing depressional wetlands, known as Carolina bays. Rainfall and temperature data were compared with water-table well and piezometer data in and...

  7. Let's talk about death: data collection for verbal autopsies in a demographic and health surveillance site in Malaysia

    Directory of Open Access Journals (Sweden)

    Pascale A. Allotey

    2015-07-01

    Full Text Available Background: Verbal autopsies have gained considerable ground as an acceptable alternative to medically determined cause of death. Unlike with clinical or more administrative settings for data collection, verbal autopsies require significant involvement of families and communities, which introduces important social and cultural considerations. However, there is very little clear guidance about the methodological issues in data collection. The objectives of this case study were: to explore the range of bereavement rituals within the multi-ethnic, multi-faith population of the district; to investigate the preparedness of communities to talk about death; to describe the verbal autopsy process; to assess the effects of collecting verbal autopsy data on data collectors; and to determine the most accurate sources of information about deaths in the community. Methods: A case study approach was used, using focus group discussions, indepth interviews and field notes. Thematic analyses were undertaken using NVivo. Results: Consideration of cultural bereavement practices is importance to acceptance and response rates to verbal autopsies. They are also important to the timing of verbal autopsy interviews. Well trained data collectors, regardless of health qualifications are able to collect good quality data, but debriefing is important to their health and well being. This article contributes to guidance on the data collection procedures for verbal autopsies within community settings.

  8. Elk habitat suitability map for North Carolina

    Science.gov (United States)

    Williams, Steven G.; Cobb, David T.; Collazo, Jaime A.

    2015-01-01

    Although eastern elk (Cervus elaphus canadensis) were extirpated from the eastern United States in the 19th century, they were successfully reintroduced in the North Carolina portion of the Great Smoky Mountains National Park in the early 2000s. The North Carolina Wildlife Resources Commission (NCWRC) is evaluating the prospect of reintroducing the species in other locations in the state to augment recreational opportunities. As a first step in the process, we created a state-wide elk habitat suitability map. We used medium-scale data sets and a two-component approach to iden- tify areas of high biological value for elk and exclude from consideration areas where elk-human conflicts were more likely. Habitats in the state were categorized as 66% unsuitable, 16.7% low, 17% medium, and <1% high suitability for elk. The coastal plain and Piedmont contained the most suitable habitat, but prospective reintroduction sites were largely excluded from consideration due to extensive agricultural activities and pervasiveness of secondary roads. We ranked 31 areas (≥ 500 km2) based on their suitability for reintroduction. The central region of the state contained the top five ranked areas. The Blue Ridge Mountains, where the extant population of elk occurs, was ranked 21st. Our work provides a benchmark for decision makers to evaluate potential consequences and trade-offs associated with the selection of prospective elk reintroduction sites.

  9. Validity of verbal autopsy method to determine causes of death among adults in the urban setting of Ethiopia

    Directory of Open Access Journals (Sweden)

    Misganaw Awoke

    2012-08-01

    Full Text Available Abstract Background Verbal autopsy has been widely used to estimate causes of death in settings with inadequate vital registries, but little is known about its validity. This analysis was part of Addis Ababa Mortality Surveillance Program to examine the validity of verbal autopsy for determining causes of death compared with hospital medical records among adults in the urban setting of Ethiopia. Methods This validation study consisted of comparison of verbal autopsy final diagnosis with hospital diagnosis taken as a “gold standard”. In public and private hospitals of Addis Ababa, 20,152 adult deaths (15 years and above were recorded between 2007 and 2010. With the same period, a verbal autopsy was conducted for 4,776 adult deaths of which, 1,356 were deceased in any of Addis Ababa hospitals. Then, verbal autopsy and hospital data sets were merged using the variables; full name of the deceased, sex, address, age, place and date of death. We calculated sensitivity, specificity and positive predictive values with 95% confidence interval. Results After merging, a total of 335 adult deaths were captured. For communicable diseases, the values of sensitivity, specificity and positive predictive values of verbal autopsy diagnosis were 79%, 78% and 68% respectively. For non-communicable diseases, sensitivity of the verbal autopsy diagnoses was 69%, specificity 78% and positive predictive value 79%. Regarding injury, sensitivity of the verbal autopsy diagnoses was 70%, specificity 98% and positive predictive value 83%. Higher sensitivity was achieved for HIV/AIDS and tuberculosis, but lower specificity with relatively more false positives. Conclusion These findings may indicate the potential of verbal autopsy to provide cost-effective information to guide policy on communicable and non communicable diseases double burden among adults in Ethiopia. Thus, a well structured verbal autopsy method, followed by qualified physician reviews could be capable of

  10. Point and Fixed Plot Sampling Inventory Estimates at the Savannah River Site, South Carolina.

    Energy Technology Data Exchange (ETDEWEB)

    Parresol, Bernard, R.

    2004-02-01

    This report provides calculation of systematic point sampling volume estimates for trees greater than or equal to 5 inches diameter breast height (dbh) and fixed radius plot volume estimates for trees < 5 inches dbh at the Savannah River Site (SRS), Aiken County, South Carolina. The inventory of 622 plots was started in March 1999 and completed in January 2002 (Figure 1). Estimates are given in cubic foot volume. The analyses are presented in a series of Tables and Figures. In addition, a preliminary analysis of fuel levels on the SRS is given, based on depth measurements of the duff and litter layers on the 622 inventory plots plus line transect samples of down coarse woody material. Potential standing live fuels are also included. The fuels analyses are presented in a series of tables.

  11. Translating caring theory into practice: the Carolina Care Model.

    Science.gov (United States)

    Tonges, Mary; Ray, Joel

    2011-09-01

    This article describes how one organization operationalized Swanson Caring Theory and changed practice to ensure consistently high standards of performance. The Carolina Care Model developed at the University of North Carolina Hospitals is designed to actualize caring theory, support practices that promote patient satisfaction, and transform cultural norms. Evaluation suggests that this approach to care delivery enhances patients' and families' hospital experience and facilitates desired outcomes. The authors outline the Professional Practice Model, key characteristics of Carolina Care, links to caring theory, and development and implementation methodologies.

  12. Little River Inlet Navigation Project, Brunswick County, North Carolina and Horry County, South Carolina. Revision.

    Science.gov (United States)

    1977-06-01

    and the adult stages of several microscopic invertebrates. Adult stages of several macroin- vertebrates such as jellyfish (Chrysaora, Cyanea...vege- 1 , rine fishes and free swimming invertebrates. Another " nr i, the clapper rail, a permanent resident of these r,)ns ard eqrets feed on fish...South Carolina estuaries. In press in G. 0. Mackie 0 (t:d.), Colelenttrate ecology and behavior . Plenum Press, New York. 7. Calder, D. R., C. M. Bearden

  13. Shot navigation for North Carolina barrier island ground penetrating radar collected by East Carolina University in 2001 (ilgpr2001_shots.shp)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The northeastern North Carolina coastal system, from False Cape, Virginia, to Cape Lookout, North Carolina, has been studied by a cooperative research program that...

  14. Ground Penetrating Radar (GPR) trackline navigation collected by East Carolina University along the North Carolina barrier islands in 2001 (ilgpr2001_tracklines.shp)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The northeastern North Carolina coastal system, from False Cape, Virginia, to Cape Lookout, North Carolina, has been studied by a cooperative research program that...

  15. JPEG Images of Ground Penetrating Radar (GPR) data collected by East Carolina University along North Carolina Outer Banks 2002-2005

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The northeastern North Carolina coastal system, from False Cape, Virginia, to Cape Lookout, North Carolina, has been studied by a cooperative research program that...

  16. Ground Penetrating Radar (GPR) trackline navigation collected by East Carolina University along the North Carolina barrier islands in 2005 (ilgpr2005_tracklines.shp)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The northeastern North Carolina coastal system, from False Cape, Virginia, to Cape Lookout, North Carolina, has been studied by a cooperative research program that...

  17. Shot navigation for North Carolina barrier island ground penetrating radar collected by East Carolina University in 2002 (ilgpr2002_shots.shp)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The northeastern North Carolina coastal system, from False Cape, Virginia, to Cape Lookout, North Carolina, has been studied by a cooperative research program that...

  18. Ground Penetrating Radar (GPR) trackline navigation collected by East Carolina University along the North Carolina barrier islands in 2002 (ilgpr2002_tracklines.shp)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The northeastern North Carolina coastal system, from False Cape, Virginia, to Cape Lookout, North Carolina, has been studied by a cooperative research program that...

  19. Sepsis and meningoencephalitis due to Rhodotorula glutinis in a patient with systemic lupus erythematosus, diagnosed at autopsy.

    Science.gov (United States)

    Pamidimukkala, Umabala; Challa, Sundaram; Lakshmi, Vemu; Tandon, Ashwani; Kulkarni, Srinivas; Raju, Satyanarayana Y

    2007-01-01

    Rhodotorula species have been reported as a causative agent of opportunistic mycoses in immunocompromised hosts. We report a case of sepsis and meningoencephalitis caused by Rhodotorula glutinis in a 20-year-old female patient with systemic lupus erythematosus (SLE), which was diagnosed at autopsy. The patient presented with longstanding fever. She was diagnosed with SLE after admission to the hospital and died on day 5 of the hospital stay. Autopsy was performed to confirm the presence of infection. Sepsis and meningoencephalitis due to Rhodotorula glutinis was confirmed by postmortem blood cultures and histopathological examination of biopsies taken from the brain at autopsy. Infection by Rhodotorula spp. is rare but can be fatal in immunocompromised hosts. Infections by such uncommon yeasts may often be difficult to diagnose, especially in the setting of febrile neutropenia. This report also emphasizes the value of autopsy as a powerful educational tool.

  20. Diagnosis of fatal pulmonary fat embolism with minimally invasive virtual autopsy and post-mortem biopsy.

    Science.gov (United States)

    Filograna, Laura; Bolliger, Stephan A; Spendlove, Danny; Schön, Corinna; Flach, Patricia M; Thali, Michael J

    2010-09-01

    We report a case of a 78-year-old female with a proximal femur fracture caused by an accidental fall who died suddenly 1h after orthopaedic prosthesis insertion. Post-mortem computed tomography (CT) scan and histological examination of samples obtained with post-mortem percutaneous needle biopsies of both lungs were performed. Analysis of the medical history and the clinical scenario immediately before death, imaging data, and biopsy histology established the cause of death without proceeding to traditional autopsy. It was determined to be acute right ventricular failure caused by massive pulmonary fat embolism. Although further research in post-mortem imaging and post-mortem tissue sampling by needle biopsies is necessary, we conclude that the use of CT techniques and percutaneous biopsy, as additional tools, can offer a viable alternative to traditional autopsy in selected cases and may increase the number of minimally invasive forensic examinations performed in the future. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

  1. Photogrammetric documentation of regions of interest at autopsy--a pilot study.

    Science.gov (United States)

    Slot, Liselott; Larsen, Peter K; Lynnerup, Niels

    2014-01-01

    In this pilot study, the authors tested whether photogrammetry can replace or supplement physical measurements made during autopsies and, based on such measurements, whether virtual computer models may be applicable in forensic reconstructions. Photogrammetric and physical measurements of markers denoting wounds on five volunteers were compared. Virtual models of the volunteers were made, and the precision of the markers' locations on the models was tested. Twelve of 13 mean differences between photogrammetric and physical measurements were below 1 cm, which indicates that the photogrammetric method has a high accuracy. The precision of the markers' location on the models was somewhat less, although the method is still promising and potentially superior to the current procedures used for reconstructions. The possibility to measure any distance on a body, even after the autopsy is concluded and the corpse is no longer available, is one of the biggest benefits of photogrammetry. © 2013 American Academy of Forensic Sciences.

  2. Malignant amelanotic melanoma of the pleura without primary skin lesion:an autopsy case report.

    Science.gov (United States)

    Ohata, Yuichiro; Haga, Takayuki; Ogata, Sho; Nakanishi, Kuniaki; Kawai, Toshiaki

    2009-12-01

    Melanoma metastasizing to the lungs is common, but primary pulmonary or pleural melanoma is extremely rare. We present an autopsy case of malignant melanoma of the pleura without primary skin lesion in a 49-year-old man. A mass found in the right chest was diagnosed as spindle cell sarcoma by antemortem fine-needle aspiration cytology. At autopsy, a yellow-white tumor located primarily in the right visceral pleura (diagnosed as an amelanotic melanoma) was found to have invaded into the right lung, right parietal pleura, and right diaphragm, and to have metastasized into the left lung and visceral pleura, thyroid, and left adrenal gland. No primary site was found. The tumor cells were positive for S100 and focally positive for HMB-45, but negative for other markers. Immuno-histochemical examination for S100 and HMB-45 would thus appear to be useful for the diagnosis of an amelanotic melanoma.

  3. Fetal echopsy (ultrasonographic autopsy of an acardius myelancephalus and its correlation with antenatal ultrasonographic findings

    Directory of Open Access Journals (Sweden)

    Balakumar Karippaliyil

    2015-01-01

    Full Text Available Aberrant transplacental arteriovenous shunts between the placental and cord vessels of monozygotic monoamniotic twins or triplets result in the formation of an acardius. The prenatal diagnosis of this condition has been reported occasionally in the literature. A subtype categorized as acardius myelancephalus was diagnosed at 32 weeks of gestation by ultrasonography (USG. The pregnancy was aborted because of poor prognostic predictors and the acardius was subjected to ultrasonographic autopsy (fetal echopsy. The antenatal USG features were correlated with echopsy findings for confirmation of the antenatal findings and for a better visual perception of the prenatal diagnostic features. The echopsy revealed more precise details. Fetal echopsy avoids the medicolegal problems concerned with parental consent for classical invasive fetal autopsy.

  4. Widespread inflammation in CLIPPERS syndrome indicated by autopsy and ultra-high-field 7T MRI

    DEFF Research Database (Denmark)

    Blaabjerg, Morten; Ruprecht, Klemens; Sinnecker, Tim

    2016-01-01

    OBJECTIVE: To examine if there is widespread inflammation in the brain of patients with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) syndrome by using histology and ultra-high-field MRI at 7.0T. METHODS: We performed a detailed...... neuropathologic examination in 4 cases, including 1 autopsy case, and studied 2 additional patients by MRI at 7.0T to examine (1) extension of inflammation to areas appearing normal on 3.0T MRI, (2) potential advantages of 7.0T MRI compared to 3.0T MRI in reflecting widespread inflammation, perivascular pathology......, and axonal damage, and (3) the possibility of lymphoma. RESULTS: In the autopsy case, perivascular inflammation dominated by CD4+ T cells was not only detected in the brainstem and cerebellum but also in brain areas with normal appearance on 3.0T MRI, including supratentorial regions and cranial nerve roots...

  5. Northern and Southern blot analysis of human RNA and DNA in autopsy material

    DEFF Research Database (Denmark)

    Larsen, S; Rygaard, K; Asnaes, S

    1992-01-01

    Fresh biopsy material for molecular biological investigations is not obtainable from all relevant normal human tissues. We studied the feasibility of using RNA and DNA from autopsies for Northern and Southern blot analysis. Tissue samples from seven organs were obtained from 10 autopsies performed...... 21-118 h postmortem. Extracted RNA and DNA were examined by Northern and Southern blot analysis using oligo-labelled human DNA probes recognizing gene transcripts of 2-5 kb. The results indicated that, in general, Northern blot analysis was feasible with the applied probes when the tissue...... was obtained less than two days postmortem. Histological examination showing slight or no autolysis and the presence of ribosomal bands after gel electrophoresis were both indicative parameters of RNA preservation. DNA was appropriate for Southern blotting when the tissue was obtained less than three to five...

  6. The First Survey of Forensically Important Entomofauna Collected from Medicolegal Autopsies in South Korea

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    Sang Eon Shin

    2015-01-01

    Full Text Available Forensic entomology applies insect evidence to legal problems such as the estimation of minimum postmortem interval (mPMI. For this purpose, knowledge of the insect fauna that are attracted to human cadavers in each geographic region is a prerequisite. Despite many studies investigating the insect fauna attracted to meat, there has been no survey of the entomofauna on human cadavers in the East Asian temperate climate zone, particularly in Korea. Therefore, this study reports the entomofauna collected from medicolegal autopsies in northeastern Seoul and its suburbs. Insect samples were collected from 35 medicolegal autopsies in 2010, 2011, and 2013. Molecular and morphological methods were utilized for taxonomic identification. Among 1398 individual samples belonging to 3 orders, 13 families, 18 genera, and 32 species, the dominant family and species were Calliphoridae and Lucilia sericata, respectively. Despite its limited scale, this study provides a snapshot of the general entomofauna that are attracted to human cadavers in this region.

  7. CASE REPORT: Papillary Adenoma of Kidney- An Incidental Autopsy Finding: Report of Two Cases

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    Bhakti D. Deshmukh

    2012-01-01

    Full Text Available Background: Renal papillary adenoma is usually an incidental finding at autopsy with an incidence of 7% to 23%. The frequency of small papillary tumours of kidney increases with age to approximately 40% of the population over the age of 65. These tumours occur morefrequently in scarred kidneys, acquired renal cystic disease and in children with von Hippel-Lindau syndrome. Case history: In this report we describe renal papillary adenoma incidentally detected during autopsies of two elderly males. Gross examination of kidneyshowed two tiny subcapsular yellowish nodules in one case and single nodule with similar morphology in the other. Microscopic examination in both the cases showed a well circumscribed tumour composed of densely packed tubules and papillae lined by small cuboidal to columnar cells with rounded uniform nuclei. However there was no nuclear atypia, mitosis or necrosis.

  8. Dopamine Neurons in the Ventral Tegmental Area: An Autopsy Case of Disorganized Type of Schizophrenia

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    Keiko Ikemoto

    2011-01-01

    Full Text Available The mesolimbic dopamine (DA system has been associated with the pathogenesis of schizophrenia. Here, we examined DA-containing neuronal structures of the ventral tegmental area (VTA of an autopsy case of disorganized type of schizophrenia (75-year-old female, using tyrosine hydroxylase (TH immunohistochemistry. A free floating method using 50-μm cryostat sections and three-dimensional imaging analyzer AxioVision were applied to observe the wide range structures of TH-immunoreactive (-ir neurons. TH-ir neuronal cell bodies in the VTA of the present case had irregular shape and various size, and TH-ir neuronal processes had irregular thickness and straightened shape or curved shape having many corners, when compared to a control autopsy case with no detectable neurological and psychiatric diseases (64-year-old male. The mechanisms underlying the morphological characteristics of DA neurons of the brains with schizophrenia should be elucidated epigenetically as well as genetically.

  9. Virtual autopsy using multislice computed tomography in forensic medical diagnosis of drowning.

    Science.gov (United States)

    Ambrosetti, M C; Barbiani, C; El-Dalati, G; Pellini, E; Raniero, D; De Salvia, A; Pozzi Mucelli, R

    2013-06-01

    This study evaluated the usefulness of multidetector computed tomography (MDCT) in the postmortem diagnosis of death by drowning in fresh water by measuring the difference of blood density within the cardiac chambers. Twenty-two corpses including six cases of fresh-water drowning (group A) and 16 deaths by other causes (group B), among which were also different forms of mechanical asphyxia other than drowning, underwent MDCT and conventional autopsy. Blood density within the right and left heart chambers, the aorta and the pulmonary trunk was measured and values compared between groups and within each group between heart chambers. Blood density in all cardiac chambers was lower in group A than in group B. The difference was statistically significant within the left atrium and ventricle and was significantly lower in the left than in the right heart chambers in group A only. MDCT, together with conventional autopsy, may contribute to the diagnosis of drowning, by measuring blood density in the heart chambers.

  10. DCP Series

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    Philip Stearns

    2011-06-01

    Full Text Available Photo essay. A collection of Images produced by intentionally corrupting the circuitry of a Kodak DC280 2 MP digitalcamera. By rewiring the electronics of a digital camera, glitched images are produced in a manner that parallels chemically processing unexposed film or photographic paper to produce photographic images without exposure to light. The DCP Series of Digital Images are direct visualizations of data generated by a digital camera as it takes a picture. Electronic processes associated with the normal operations of the camera, which are usually taken for granted, are revealed through an act of intervention. The camera is turned inside­out through complexes of short­circuits, selected by the artist, transforming the camera from a picture taking device to a data capturing device that renders raw data (electronic signals as images. In essence, these images are snap­shots of electronic signals dancing through the camera's circuits, manually rerouted, written directly to the on­board memory device. Rather than seeing images of the world through a lens, we catch a glimpse of what the camera sees when it is forced to peer inside its own mind.

  11. Comparative study of conventional and virtual autopsy using postmortem MRI in the phenotypic characterization of stillbirths and malformed fetuses.

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    Shruthi, Mohan; Gupta, Neerja; Jana, Manisha; Mridha, Asit R; Kumar, Atin; Agarwal, Ramesh; Sharma, Raju; Deka, Dipika; Gupta, Arun Kumar; Kabra, Madhulika

    2017-03-13

    To prospectively compare conventional and virtual autopsy using postmortem-MRI in the phenotypic characterization of stillbirths and malformed fetuses and their acceptability to parents. We performed whole body postmortem-MRI (1.5T) prior to conventional autopsy in 43 fetuses/still births (≥20 weeks of gestation) after excluding maternal causes of fetal death. With conventional autopsy as gold standard, postmortem-MRI findings were assessed and compared. Malformations found in postmortem-MRI were compared with conventional autopsy. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of post-mortem MRI with 95% CI, taking conventional autopsy as gold standard respectively were, whole body [77.7% (72.4%-82.4%), 99.8% (99.6%-99.9%), 97.4% (94.4%-99.0%), 97.9% (97.4%-98.4%)], nervous system [93.1% (77.2%-99.15%), 99.0% (97.5%-99.7%), 87.1% (70.2%-96.4%), 99.5% (98.2%-99.9%)], cardiovascular system [60.9% (44.5%-75.8%), 100.0% (99.2%-100.0%), 100.0% (86.3%-100.0%), 96.7% (94.8%-98.1%)], pulmonary system [91.1% (80.4%-97.0%), 100.0% (98.5%-100.0%), 100.0% (93.0%-100.0%), 98.0% (95.4%-99.3%)], abdomen [80.6% (63.9%-91.8%), 99.8% (98.9%-100.0%), 96.7% (82.8%-99.9%), 98.7% (97.3%-99.5%)], renal system [96.1% (80.4%-99.9%), 99.7% (98.1%-99.9%), 96.1% (80.4%-99.9%), 99.7% (98.1%-99.9%)], and musculoskeletal system [66.8% (56.5%-75.8%), 100.0% (99.7%-100.0%), 100.0% (94.6%-100.0%), 97.2% (96.1%-98.1%)]. In 35 (81.4%) out of 43 cases, final diagnosis based on virtual autopsy using postmortem-MRI was concordant with that of conventional autopsy. Virtual autopsy was acceptable to 93.6% of families as compared to conventional autopsy in 82.5%. Virtual autopsy using external examination of fetus, post-mortem MRI and other non-invasive/minimally invasive investigations can be an acceptable alternative to conventional autopsy when refused. Postmortem-MRI provides additional diagnostic information in brain and spinal cord malformations. Also

  12. Genomic Triangulation and Coverage Analysis in Whole-Exome Sequencing-Based Molecular Autopsies.

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    Shanks, Garrett W; Tester, David J; Nishtala, Sneha; Evans, Jared M; Ackerman, Michael J

    2017-10-01

    WEMA (Whole-Exome Molecular Autopsy) and surveillance of cardiac channelopathy and cardiomyopathy genes represents the latest molecular autopsy for sudden death in the young (SDY). To date, the majority of WEMA has been performed on the SDY case only. We performed whole-exome sequencing and nucleotide-level coverage analysis on 28 SDY cases (18.4±7.8 years) and their parents to determine the inheritance patterns of ultrarare, nonsynonymous variants in 99 sudden death-susceptibility genes. Nonsynonymous variants were adjudicated using the American College of Medical Genetics guidelines. Overall, 17 sudden death-susceptibility gene variants were identified in 12 of 28 (43%) SDY cases. On the basis of the American College of Medical Genetics guidelines, 6 of 28 (21%) cases had a pathogenic or likely pathogenic nonsynonymous variant with 3 (50%) being de novo. Two nonsynonymous variants would not have been elevated to likely pathogenic status without knowing their de novo status. Whole-exome sequencing reached a read depth of 10× across 90% of nucleotides within sudden death-susceptibility genes in 100% of parental exomes from fresh blood draw, compared with only 82% of autopsy-sourced SDY exomes. An SDY-parent, trio-based WEMA may be an effective way of elucidating a monogenic cause of death and bringing clarity to otherwise ambiguous variants. If other studies confirm this relatively high rate of SDY cases stemming from de novo mutations, then the WEMA should become even more cost-effective given that the decedent's first-degree relatives should only need minimal cardiological evaluation. In addition, autopsy-sourced DNA demonstrated strikingly lower whole-exome sequencing coverage than DNA from fresh blood draw. © 2017 American Heart Association, Inc.

  13. High-speed documented experimental gunshot to a skull-brain model and radiologic virtual autopsy.

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    Thali, Michael J; Kneubuehl, Beat P; Vock, Peter; Allmen, Gabriel v; Dirnhofer, Richard

    2002-09-01

    The authors documented and evaluated experimental gunshots to a skull-brain model with high-speed photography and subsequent radiographic examination for comparison of the morphologic findings in the model. The artificial skull was a polyurethane ball constructed in layers, with a porous diploe sandwiched between a tabula externa and a tabula interna. The brain itself was simulated with gelatin 10% at 4 degrees C, a material well known in wound ballistics. Gunshots were fired at the model from a distance of 10 m and documented with high-speed photography (up to 50 million frames/sec). Subsequently, a complete examination of the artificial skull was performed, including spiral computed tomography (with two-dimensional and three-dimensional reconstructions) and classic skull autopsy. The high-speed photographs clearly showed the dynamic development of the skull fracture system from an external perspective. The subsequent radiographic examination of the entire head volume created two-dimensional reformations in any plane and three-dimensional reconstructions of the gunshot injury of the polyurethane skull-brain model, especially the wound channel and the fracture system. Thanks to the model and high-speed photographs, the dynamic development of the morphology of a gunshot wound could be documented and studied. The data from computed tomography, using two-dimensional and three-dimensional postprocessing with a perspective view, were very similar to those from classic head autopsy, but derived in a hands-off and nondestructive manner. This examination method leads the way to radiographic digital autopsy or virtual autopsy.

  14. An autopsy case of myocardial infarction due to idiopathic thrombotic thrombocytopenic purpura

    OpenAIRE

    Tasaki, Takashi; Yamada, Sohsuke; Nabeshima, Atsunori; Noguchi, Hirotsugu; Nawata, Aya; Hisaoka, Masanori; Sasaguri, Yasuyuki; Nakayama, Toshiyuki

    2015-01-01

    Abstract Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder characterized by systemic platelet-von Willebrand factor aggregation, organ ischemia and profound thrombocytopenia. In this report, we describe an autopsy case of a 77-year-old Japanese man diagnosed with idiopathic TTP. He had no history of cardiovascular disease symptoms, such as chest pain, ST segment elevation, and elevation of cardiac enzyme levels, except arrhythmia. The patient suddenly died despite recei...

  15. Two forensic autopsy cases of death from unexpected lesions of the pituitary gland.

    Science.gov (United States)

    Suzuki, Hideto; Hayashi, Kino; Fukunaga, Tatsushige

    2014-01-01

    Herein, we report the findings of 2 forensic autopsy cases, in which unexpected pituitary lesions were the underlying cause of death. Case 1: A 56-year-old woman was found dead at her home during a cold winter spell. Macroscopic autopsy findings included a difference in the color of blood that filled her left and right cardiac chambers (deep red and dark red, respectively), collapse of both lungs, atrophy of the thyroid gland, and a large tumor arising from the sella turcica. Microscopic examination revealed a pituitary adenoma along with extensive bleeding. The cause of death was considered to be hypothermia, resulting from dysregulation of thermogenesis due to the pituitary adenoma. Case 2: An 86-year-old man with a history of pollakiuria was found dead in a bathtub, with his face and chest submerged in bathwater and his legs positioned outside the bathtub. The macroscopic findings of the autopsy included hyper-inflated lungs, fluid collection in the thoracic cavity, and aspiration of gastric contents in the bronchi. The atherosclerotic changes of the man's coronary and cerebral arteries were considered mild for his age. Microscopic examination showed a marked infiltration of lymphocytes and plasma cells in the posterior pituitary gland, as well as in the liver, pancreas, and submandibular gland. Considering the results of the autopsy and the findings from the investigation conducted at the death scene, we concluded that the man probably lost consciousness following a neurally mediated syncope, which was induced by diabetes insipidus (lymphocytic hypophysitis). After losing consciousness, the man likely fell in the filled bathtub and then drowned. These 2 cases highlight the need for a thorough post-mortem investigation, including a microscopic examination of the pituitary gland. In addition, forensic pathologists should carefully study the pituitary gland in cases where the cause of death is thought to be related to dysfunction of thermoregulation or

  16. Human Immunodeficiency Virus Infection Newly Diagnosed at Autopsy in New York City, 2008?2012

    OpenAIRE

    Ramaswamy, Chitra; Ellman, Tanya M.; Myers, Julie; Madsen, Ann; Sepkowitz, Kent; Shepard, Colin

    2015-01-01

    Background. ?Studying the most extreme example of late diagnosis, new HIV diagnoses after death, may be instructive to HIV testing efforts. Using the results of routine HIV testing of autopsies performed by the Office of Chief Medical Examiner (OCME), we identified new HIV diagnoses after death in New York City (NYC) from 2008 to 2012. Methods. ?Population-based registries for HIV and deaths were linked to identify decedents not known to be HIV-infected before death. Multivariable logistic re...

  17. Psychological autopsy and necropsy of an unusual case of suicide by intravenous toluene

    OpenAIRE

    Ranganath R Kulkarni; R G Hemanth Kumar; Pratibha R Kulkarni; Raghavendra B Kotabagi

    2015-01-01

    Toluene (methylbenzene; volatile hydrocarbon) is an industrial solvent that causes major injury to the lungs; the organ being the first capillary bed encountered. We report an unusual case of suicide by a 24-year-old male, paramedical professional, with fatal outcome within 16 h of intentional, intravenous self-administration of toluene, with clinical presentation of acute respiratory distress syndrome. Psychological autopsy revealed severe depressive disorder and solvent (inhalant) abuse, wi...

  18. Suicide Among Adolescents in Center Tunisia: An 18-Year Autopsy Study

    OpenAIRE

    Jedidi M; Mlayeh S; Hamila I; Masmoudi T; Ben Dhiab M; Zemni M; Souguir MK

    2016-01-01

    Background: Suicide and suicide attempts are more common among adolescents. Many factors are known to influence suicide in particular: region and culture. Adolescent suicide has been widely studied in many countries, but there are, currently, no data relating to adolescent suicide in Tunisia. Aim: The aims of this study were to describe epidemiological aspects of death related to adolescent suicide in Sousse, a city in central Tunisia. Methods: Data of forensic autopsies from 1998 to 2015 rel...

  19. Creating and validating an algorithm to measure AIDS mortality in the adult population using verbal autopsy.

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    Ben A Lopman

    2006-08-01

    Full Text Available Vital registration and cause of death reporting is incomplete in the countries in which the HIV epidemic is most severe. A reliable tool that is independent of HIV status is needed for measuring the frequency of AIDS deaths and ultimately the impact of antiretroviral therapy on mortality.A verbal autopsy questionnaire was administered to caregivers of 381 adults of known HIV status who died between 1998 and 2003 in Manicaland, eastern Zimbabwe. Individuals who were HIV positive and did not die in an accident or during childbirth (74%; n = 282 were considered to have died of AIDS in the gold standard. Verbal autopsies were randomly allocated to a training dataset (n = 279 to generate classification criteria or a test dataset (n = 102 to verify criteria. A rule-based algorithm created to minimise false positives had a specificity of 66% and a sensitivity of 76%. Eight predictors (weight loss, wasting, jaundice, herpes zoster, presence of abscesses or sores, oral candidiasis, acute respiratory tract infections, and vaginal tumours were included in the algorithm. In the test dataset of verbal autopsies, 69% of deaths were correctly classified as AIDS/non-AIDS, and it was not necessary to invoke a differential diagnosis of tuberculosis. Presence of any one of these criteria gave a post-test probability of AIDS death of 0.84.Analysis of verbal autopsy data in this rural Zimbabwean population revealed a distinct pattern of signs and symptoms associated with AIDS mortality. Using these signs and symptoms, demographic surveillance data on AIDS deaths may allow for the estimation of AIDS mortality and even HIV prevalence.

  20. Association of pulmonary histopathological findings with toxicological findings in forensic autopsies of illicit drug users

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    Todorović Miloš S.

    2011-01-01

    Full Text Available Background/Aim. Drug abuse remains a significant social problem in many countries. The aim of the study was to estimate association between pulmonary histopathological changes and results of toxicological analyses in forensic autopsies of illicit drug users. Methods. This investigation was performed in the Institute of Forensic Medicine, Belgrade, and in the Clinical Center, Department of Forensic Medicine, Kragujevac, from 2000 to 2004, and included 63 medicolegal autopsies of heroin or other drug consumers who suddenly died. Autopsies, postmortem toxicological examination of drugs and serological analyses of anti- HIV/HBV/HCV antibodies were performed. Results. The deceased persons were mostly male, 46/63 (73.01%, ranged in age from 19 to 49 years (mean 31 years and all were whites. Postmortem toxicological examination was performed on all of the deceased persons and drugs in the fatal range were identified in only eight of them (12.7%, in the toxic range in ten (15.87%, and in minimal concentrations in 35 (55.56% of the deceased persons. Drugs identified in the fatal, toxic or minimal range included heroin-morphine (38/53, cocaine (4/53, tramadol (3/53, and lorazepam (1/53. In the 7 remaining subjects, ethanol in combination with heroin was found in 4 cases, and diazepam in combination with heroin in 3 cases. Dominant pathomorphological changes were findings in the lung tissue. Most common histological changes observed in drug users were pulmonary edema - 55/63 (87.3%, acute alveolar hemorrhages - 49/63 (77.78%, hemosiderin-laden macrophages (siderophages - 52/63 (82,54%, and emphysematous changes - 51/63 (80,95%. Conclusion. Pulmonary edema is the frequent non-specific autopsy finding which is associated with virtually all routes of drug administration. The histopatological study is necessary to determinate a cause of death when a deceased person has the history of dependence or abouse of psychoactive drugs with negative toxicological

  1. Pathology Results at Autopsy in Brain-Dead Patients with Brain Tumors.

    Science.gov (United States)

    Sadegh Beigee, Farahnaz; Shahryari, Shagin; Mojtabaee, Meysam; Pourabdollah Toutkaboni, Mihan

    2017-02-01

    Brain tumors are the most challenging causes of brain deaths due to the lack of pathology results in many cases. It is not uncommon to find a brain tumor in a brain-dead patient with no pathology results or neuroradiology reports available; this would exclude the deceased from organ donation. The mortality that occurs while patients are on transplant wait lists motivated us to find a solution to prevent losing brain-dead patients as potential donors. We present our experiences in autopsy examinations of brain tumors and the results of frozen-section pathology. We performed autopsy examinations of 8 brain-dead patients who were suspected of having highly malignant brain tumors and in whom there were no pathology or radiology reports available. The autopsy process began at the conclusion of organ retrieval. First, we performed a complete brain dissection; the tumor was then removed with its adjacent brain tissue and sent for examination by an expert pathologist. Organ transplant was deferred until the pathology examination was completed. Organ transplant was cancelled if the frozen sections revealed a high-grade tumor. For all other results, the transplant was performed. If a medulloblastoma was confirmed, only the heart was transplanted. The duration of the delay for pathologic examination was 30 to 45 minutes. A total of 21 organs were donated that would otherwise have been rejected. It is worth performing an autopsy and frozen-section pathology examination to prevent losing potential organs from donors with brain tumors who are suspected of having a high-grade neoplasm but have no pathology or neuroradiology reports. This process is simple and has the potential to save lives.

  2. Genetic analysis of sudden cardiac death victims: a survey of current forensic autopsy practices.

    Science.gov (United States)

    Michaud, Katarzyna; Mangin, Patrice; Elger, Bernice S

    2011-05-01

    Autopsy-negative sudden cardiac deaths (SCD) seen in forensic practice are most often thought to be the result of sudden arrhythmic death syndrome. Postmortem genetic analysis is recommended in such cases, but is currently performed in only a few academic centers. In order to determine actual current practice, an on-line questionnaire was sent by e-mail to members of various forensic medical associations. The questions addressed routine procedures employed in cases of sudden cardiac death (autopsy ordering, macroscopic and microscopic cardiac examination, conduction tissue examination, immunohistochemistry and electron microscopy, biochemical markers, sampling and storage of material for genetic analyses, toxicological analyses, and molecular autopsy). Some questions concerned the legal and ethical aspects of genetic analyses in postmortem examinations, as well as any existing multidisciplinary collaborations in SCD cases. There were 97 respondents, mostly from European countries. Genetic testing in cases of sudden cardiac death is rarely practiced in routine forensic investigation. Approximately 60% of respondents reported not having the means to perform genetic postmortem testing and 40% do not collect adequate material to perform these investigations at a later date, despite working at university hospitals. The survey demonstrated that many of the problems involved in the adequate investigation of SCD cases are often financial in origin, due to the fact that activities in forensic medicine are often paid by and dependent on the judicial authorities. Problems also exist concerning the contact with family members and/or the family doctor, as well as the often-nonexistent collaboration with others clinicians with special expertise beneficial in the investigation of SCD cases, such as cardiologists and geneticists. This study highlights the importance in establishing guidelines for molecular autopsies in forensic medicine.

  3. Cardiovascular Health of North Carolina Undergraduates.

    Science.gov (United States)

    Lai, Hsiao L; Ward, Rachel; Bolin, Paul

    2015-01-01

    Cardiovascular disease is highly prevalent in Eastern North Carolina (ENC). In this study, we investigated cardiometabolic risk in young adults of ENC by sampling entrant undergraduates at East Carolina University (ECU). From June to October of 2010, 525 undergraduates were screened for elevated body mass index (BMI), blood pressure, lipids, blood glucose, inactivity, smoking, history of diabetes or hypertension, and family history of coronary disease. Participants were classified as high-risk if they had 3 or more cardiovascular risk factors or as "MetS" if they satisfied the criteria for metabolic syndrome. Forty-four percent of those screened had 2 or more risk factors, 12.5% had 3 or more risk factors, and 1.3% met criteria for MetS. Low levels of high-density lipoprotein (27.6%), overweight status (27.2%), and inactivity (27.1%) were leading risks. Females had an increased risk of inactivity compared to males (relative risk [RR] = 1.81; 95% CI, 1.3-2.52). Blacks had a 4-fold higher risk of metabolic syndrome (RR = 4.21; 95% Cl, 1.0-18.4), and black females had a high risk for obesity (RR = 5.7; 95% CI, 2.5-13) and systolic blood pressure elevation (RR = 4.8; 95% Cl, 1.5-15). Students recognized cardiovascular disease as a valid risk to their well-being. ECU undergraduates have a high prevalence of multiple cardiovascular risk factors. High-risk and MetS students recognize cardiovascular disease as a significant health risk, but they mistakenly maintain the self-perception that they are healthy. Efforts to understand risk perception and personal strategies of risk application are needed for this population of young adults.

  4. An autopsy case of myocardial infarction due to idiopathic thrombotic thrombocytopenic purpura.

    Science.gov (United States)

    Tasaki, Takashi; Yamada, Sohsuke; Nabeshima, Atsunori; Noguchi, Hirotsugu; Nawata, Aya; Hisaoka, Masanori; Sasaguri, Yasuyuki; Nakayama, Toshiyuki

    2015-05-29

    Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder characterized by systemic platelet-von Willebrand factor aggregation, organ ischemia and profound thrombocytopenia. In this report, we describe an autopsy case of a 77-year-old Japanese man diagnosed with idiopathic TTP. He had no history of cardiovascular disease symptoms, such as chest pain, ST segment elevation, and elevation of cardiac enzyme levels, except arrhythmia. The patient suddenly died despite receiving many treatments. On autopsy, macroscopically and microscopically, acute and chronic myocardial infarction manifested as petechiae and fibrotic foci and covered a wide area in the myocardium, including the area near the atrioventricular node. The microthrombi in the small arterioles and capillaries were platelet thrombi, which showed positive results for periodic acid-Schiff stain and factor VIII on immunohistochemical staining. The cause of the sudden death was suspected to be myocardial infarction, including a cardiac conduction system disorder due to multiple platelet microthrombi. Asymptomatic myocardial infarction is an important cause of death in TTP. Therefore, the heart tissue, including the sinus-atrial node and the atrioventricular node, should be microscopically examined more closely in autopsy cases of patients with TTP who experienced sudden death of TTP. This report is a critical teaching case considering that its cause of sudden death may be arrhythmia due to a myocardial infarction including cardiac conduction system disorder by platelet microthrombi. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2113354005156739.

  5. Feasibility of liver weight estimation by postmortem computed tomography images: an autopsy study.

    Science.gov (United States)

    Inai, Kunihiro; Noriki, Sakon; Kinoshita, Kazuyuki; Nishijima, Akihiko; Sakai, Toyohiko; Kimura, Hirohiko; Naiki, Hironobu

    2014-07-01

    Although organ weight gives pathologists information about the pathogenesis of diseases at autopsy, the knowledge is rarely helpful in postmortem virtual autopsy by computed tomography (CT). To investigate the feasibility of liver weight estimation based on liver volume estimated from three-dimensional CT images and the specific gravity of liver, thirty cadavers who died in the University of Fukui Hospital and whose family members agreed to postmortem CT and autopsy were prospectively enrolled. Mean specific gravity of liver was 1.054 ± 0.009 g/mL (95% confidence interval: 1.0507-1.0573 g/mL). The specific gravity was positively correlated to Hounsfield unit (HU) values of less than 40 (cases with moderate to severe fatty deposition) and remained stable between 1.05 to 1.065 g/mL for HU values greater than 40 (cases with mild or no fatty change). The liver weight estimated by our formula corresponded well to the actual liver weight, and the correlation coefficient was 0.96 (P < 1 × 10(-13) ). The estimated liver weight calculated from estimated liver volume and the specific gravity of 1.055 g/mL was highly accurate, whereas the specific gravity should be reduced by 2%-3% in patients with an HU value less than 40 due to fatty deposition. © 2014 The Authors. Pathology International © 2014 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd.

  6. HISTOPATHOLOGICAL PROFILE OF LIVER LESIONS IN AUTOPSY EXAMINATION- A HOSPITAL-BASED STUDY

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    Ratan Konjengbam

    2017-06-01

    Full Text Available BACKGROUND Liver is the main site of various primary and secondary diseases including variety of external agents. Most of the chronic liver diseases remained asymptomatic even in the late stage. In apparently healthy persons, many liver lesions are detected incidentally following a postmortem examination. MATERIALS AND METHODS The present study was done for a period of 5 years in a tertiary hospital to evaluate the histopathological profile of liver specimen in autopsy examination. Haematoxylin and Eosin sections of liver specimen were studied. A total of 352 samples were evaluated with male predominates the female sex in the ratio of 5.2:1. RESULTS The most common lesion was fatty liver (19% followed by cirrhosis (11.8%, venous congestion (11.5%, portal triaditis (10.9%, chronic hepatitis (6.2%, granulomatous hepatitis (2.1%, autolysis (16% and others (0.96%. Liver finding was normal in 14% of the cases. CONCLUSION Silent liver diseases are a quite regular finding in autopsy cases and thereby may implicate a common occurrence in general population. Autopsy examination of liver is a must for detection of silent liver diseases like fatty change, cirrhosis and chronic hepatitis.

  7. Clinicopathologic correlations of HIV-1-associated vacuolar myelopathy: an autopsy-based case-control study.

    Science.gov (United States)

    Dal Pan, G J; Glass, J D; McArthur, J C

    1994-11-01

    To determine the clinical correlates of HIV-1-associated vacuolar myelopathy (VM), we designed a case-control study based on 215 AIDS autopsies in which we examined the spinal cord. We defined a case as an individual dying with AIDS and with VM present at autopsy; we defined a control as an individual dying with AIDS without VM. VM was found in 100 of 215 (46.5%) autopsies, with no apparent temporal trends. A higher number of AIDS-defining illnesses was strongly associated with the likelihood of VM (trend chi-square = 26.52, p cases than in controls (odds ratio = 3.68, 95% CI = 1.73 to 7.47, p cases than in controls (odds ratio = 5.00, 95% CI = 1.35 to 18.5, p cases with VM had detailed neurologic evaluations, but only 15 (26.8%) had signs and symptoms of myelopathy. The presence of symptomatic myelopathy was related to the pathologic severity: none of 17 cases with grade 1, five of 26 with grade 2, and 10 of 13 with grade 3 had clinical features of myelopathy (trend chi-square = 21.16, p < 0.005). VM is a common neuropathologic finding that is frequently unrecognized during life. The association with the number of systemic illnesses, M avium-intracellulare infection, and P carinii pneumonia suggests that the development of VM is related to the severity of immunosuppression.

  8. Pathomorphism of central nervous system tuberculosis in school-age children (According to autopsy data

    Directory of Open Access Journals (Sweden)

    L. I. Mykolyshin

    2015-01-01

    Full Text Available Autopsy protocols for deaths of 7-14-year-old children in 1947 to 2012, which indicated tuberculosis of the central nervous system (CNS, were analyzed; the incidence of the above pathology was 80.3% among 132 children who died from tuberculosis in this period,. It was ascertained that in 1947-1956 the children died from generalized tuberculosis with involvement of CNS and other organs. As a result of induced pathomorphism, the number of autopsies reduced by 13.9 times in 1957-1966 and by 97 times in 1967-1994 as compared to 1947-1956. Changes occurred in the pattern of forms of CNS tuberculosis and the number of autopsied deaths from CNS tuberculosis concurrent with generalized tuberculosis decreased by 16.7 times; there was a decline in the number of affected organs. However, the 1995-2012 deaths from generalized tuberculosis with involvement of CNS and other organs in 7-14-year-old children are suggestive of the reversion of severe tuberculosis and the necessity of intensifying social, preventive, and remedial measures among them.

  9. Forensic autopsy practice in the Middle East: comparisons with the west.

    Science.gov (United States)

    Al-Waheeb, Salah; Al-Kandary, Nadia; Aljerian, Khaldoon

    2015-05-01

    Autopsies are performed in the majority of Arab, Muslim countries. Several of these countries face social challenges and others do not have well established academic programs to teach the science. In this article we intend to review the history and practice of the forensic part of autopsies in a few Arab, Muslim countries (Egypt, Kingdom of Saudi Arabia (KSA) and Kuwait) and compare it with the United States of America (USA) and the United Kingdom (UK), 2 countries where the practice of forensic science and Forensic pathology is well established. This was achieved by pub med literature search and the distribution of a questionnaire to colleagues in Arab countries. We recommend that Arab countries explore the field of virtual autopsy to overcome some of the social challenges related to dissection of the cadaver. Kuwait can benefit from the introduction of Forensic training given the high workload in the country. Copyright © 2015 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  10. Fetal anomalies associated with HNF1B mutations: report of 20 autopsy cases.

    Science.gov (United States)

    Duval, Hélène; Michel-Calemard, Laurence; Gonzales, Marie; Loget, Philippe; Beneteau, Claire; Buenerd, Annie; Joubert, Madeleine; Denis-Musquer, Marielee; Clemenson, Alix; Chesnais, Anne-Laure; Blesson, Sophie; De Pinieux, Isabelle; Delezoide, Anne-Lise; Bonyhay, Gheorghe; Bellanné-Chantelot, Christine; Heidet, Laurence; Dupré, Florence; Collardeau-Frachon, Sophie

    2016-08-01

    To describe macroscopic and microscopic anomalies present in fetuses carrying hepatocyte nuclear factor-1 β mutation, their frequency, and genotype/phenotype correlations. Clinical data, ultrasound findings, genetic studies, and autopsy reports of 20 fetal autopsies were analyzed. Histology was reviewed by two pathologists. Macroscopic findings were typically unilateral or bilateral renal enlargement and cortical cysts. Renal lesions were associated with congenital anomalies of the kidney and urinary tract in 25% of cases. Microscopic renal anomalies were dominated by glomerulocystic kidney and renal dysplasia. Extra-renal manifestations such as pancreatic hypoplasia (75%) and genital anomalies (68%) were only detected at autopsy. In 40% of cases, there was heterozygous deletion of the whole gene. There were de novo mutations in 40%. This study underlines the importance of considering hepatocyte nuclear factor-1 β mutations in fetuses with congenital anomalies of the kidney and urinary tract, especially when associated with pancreatic hypoplasia. No correlation between phenotype and genotype was found, highlighting high intra-familial variability in cases with inherited mutations. © 2016 John Wiley & Sons, Ltd. © 2016 John Wiley & Sons, Ltd.

  11. [Detection of wooden rod in pleural and peritoneal cavities during forensic autopsy].

    Science.gov (United States)

    Kotik, Andrei; Zaitsev, Konstantin; Hiss, Jehuda

    2013-08-01

    A rare event of fatal sexual assault by the insertion of a wooden rod through the anus to the upper chest is reported. Examination of the body at the scene did not raise any suspicion of assault while the subsequent autopsy revealed findings that changed the assessment of the cause of death and the circumstances. The body of a 57 years old man with a history of psychiatric illness was found in his room. At autopsy a round wooden rod which was inserted through the anus was found in the peritoneal and pleural cavities. In addition, signs of manual pressure were detected on the neck and trunk, and on the head and extremities signs of blunt trauma were observed. In patients affected by mental disorders it is difficult to distinguish between self-inflicted anal injuries and injuries sustained during an attack. Detection of damage to other areas of the body (such as the neck) assist in determining the nature of the assault. This case demonstrates the need for a full autopsy in every case of death under unclear circumstances, especially when a limited examination of the body can't determine the type of death (natural, accident, suicide or homicide).

  12. The distribution of the bats of South Carolina

    Energy Technology Data Exchange (ETDEWEB)

    Menzel, Jennifer M. [USDA Forest Service, Parsons, WV (United States); Menzel, Michael A. [West Virginia Univ., Morgantown, WV (United States); Ford, W. Mark [USDA Forest Service, Parsons, WV (United States); Edwards, John W. [West Virginia Univ., Morgantown, WV (United States); Sheffield, Steven R. [George Mason Univ., Fairfax, VA (United States); Kilgo, John C. [USDA Forest Service, New Ellenton, SC (United States); Bunch, Mary S. [South Carolina Dept. of Natural Resources, Pendleton, SC (United States)

    2003-03-01

    Menzel. J.M., M.A. Menzel, W.M. Ford, J.W. Edwards, S.R. Sheffield, J.C. Kilgo, and M.S. Bunch. 2003. The distribution of the bats of South Carolina. Southeastern Nat. 2(1): 121-152. There is a paucity of information available about the distribution of bats in the southeastern United States. We synthesized records from museums, bat captures, and bats submitted for rabies testing to provide a more accurate and useful distribution for natural resource managers and those planning to research bats in South Carolina. Distributional information, including maps, collection localities within counties, and literature references, for all 14 species of bats that occur in South Carolina, has never been synthesized. To provide better information on the state's bat fauna, we have updated distributions for all species that occur in South Carolina.

  13. Submerged Aquatic Vegetation of Bogue Sound, North Carolina 1992 Geodatabase

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — During 1992, 1:20,000 scale aerial photography for Bogue Sound, North Carolina was collected as part of an effort to map submerged aquatic vegetation (SAV) in...

  14. 2012 South Carolina DNR Lidar: McCormick County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Towill Inc. collected LiDAR for over 3,300 square miles in Calhoun, Aiken, Barnwell, Edgefield, McCormick, and Abbeville counties in South Carolina. This metadata...

  15. Submerged Aquatic Vegetation of Bogue Sound, North Carolina 1992 Substrate

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — During 1992, 1:20,000 scale aerial photography for Bogue Sound, North Carolina was collected as part of an effort to map submerged aquatic vegetation (SAV) in...

  16. Peat Resources Of North Carolina A Progress Report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This project is part of DOE Caroliina’s inventory of the peat resources of the United States. With support from DOE and the North Carolina Energy Institute we are...

  17. Myrtle Beach, South Carolina Tsunami Forecast Grids for MOST Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Myrtle Beach, South Carolina Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST)...

  18. Cape Hatteras, North Carolina Tsunami Forecast Grids for MOST Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Cape Hatteras, North Carolina Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST)...

  19. Morehead City, North Carolina Tsunami Forecast Grids for MOST Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Morehead City, North Carolina Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST)...

  20. Living Legacy: A Conversation with Carolina Gomez del Valle.

    Science.gov (United States)

    Montessori Life, 1993

    1993-01-01

    Carolina Gomez del Valle has been involved in training other Montessorians in Mexico, Chile, Nicaragua, Peru, and Taiwan. This interview explores her experiences with Montessori education and describes how she has woven her religious training and Montessori philosophy together. (PAM)

  1. The Christmas tree industry in western North Carolina

    Science.gov (United States)

    Jill Sidebottom

    2009-01-01

    Christmas tree production has grown in the last 50 years to one of the major farming enterprises in western North Carolina. The history, importance, and challenges to the Christmas tree industry are reviewed.

  2. Wind Powering America: The Next Steps in North Carolina

    Energy Technology Data Exchange (ETDEWEB)

    Banks, Jennifer L. [North Carolina Solar Center; Scanlin, Dennis [Appalachian State University; Quinlan, Paul [North Carolina Sustainable Energy Association

    2013-06-18

    The goal of this project is to apply the WPA’s proactive outreach strategy to the problem of educating the public about the likely transmission infrastructure developments concomitant to the significant development of wind energy resources in North Carolina. Given the lead time to develop significant new transmission infrastructure (5-10 years), it is critical to begin this outreach work today, so that wind resources can be developed to adequately meet the 20% by 2030 goal in the mid- to long-term (10-20 years). The project team planned to develop a transmission infrastructure outreach campaign for North Carolina by: (1) convening a utility interest group (UIG) of the North Carolina Wind Working Group (NC WWG) consisting of electric utilities in the state and the Southeast; and (2) expanding outreach to local and state government officials in North Carolina.

  3. Inventory and Monitoring Plan: Carolina Sandhills National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of this Inventory and Monitoring Plan (IMP) is to describe and recommend what natural resource surveys will be conducted at the Carolina Sandhills NWR...

  4. Submerged Aquatic Vegetation of Bogue Sound, North Carolina 1992 Biotic

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — During 1992, 1:20,000 scale aerial photography for Bogue Sound, North Carolina was collected as part of an effort to map submerged aquatic vegetation (SAV) in...

  5. Herpetological studies on the carolina sandhills national wildlife refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report includes information gathered concerning the biology of the amphibians and reptiles of the Carolina Sandhills National Wildlife Refuge from summer 1995...

  6. North Carolina School Performance Data 2016-2017

    Data.gov (United States)

    City and County of Durham, North Carolina — 2016-17 State, District, and School Level Drilldown Performance DataPercentages greater than 95 are displayed as >95 and percentages less than 5 are displayed as...

  7. Carolina Sandhills National Wildlife Refuge: Comprehensive Conservation Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Comprehensive Conservation Plan (CCP) was written to guide management on Carolina Sandhills NWR for the next 15 years. This plan outlines the Refuge vision and...

  8. The Trail Inventory of Carolina Sandhills NWR [Cycle 2

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of this report is to create a baseline inventory of all non-motorized trails on Carolina Sandhills National Wildlife Refuge. Trails in this inventory are...

  9. Submerged Aquatic Vegetation of Bogue Sound, North Carolina 1992 Geoform

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — During 1992, 1:20,000 scale aerial photography for Bogue Sound, North Carolina was collected as part of an effort to map submerged aquatic vegetation (SAV) in...

  10. Back to the Future - Part 1. The medico-legal autopsy from ancient civilization to the post-genomic era.

    Science.gov (United States)

    Cecchetto, Giovanni; Bajanowski, Thomas; Cecchi, Rossana; Favretto, Donata; Grabherr, Silke; Ishikawa, Takaki; Kondo, Toshikazu; Montisci, Massimo; Pfeiffer, Heidi; Bonati, Maurizio Rippa; Shokry, Dina; Vennemann, Marielle; Ferrara, Santo Davide

    2017-07-01

    Part 1 of the review "Back to the Future" examines the historical evolution of the medico-legal autopsy and microscopy techniques, from Ancient Civilization to the Post-Genomic Era. In the section focusing on "The Past", the study of historical sources concerning the origins and development of the medico-legal autopsy, from the Bronze Age until the Middle Ages, shows how, as early as 2000 BC, the performance of autopsies for medico-legal purposes was a known and widespread practice in some ancient civilizations in Egypt, the Far East and later in Europe. In the section focusing on "The Present", the improvement of autopsy techniques by Friedrich Albert Zenker and Rudolf Virchow and the contemporary development of optical microscopy techniques for forensic purposes during the 19th and 20th centuries are reported, emphasizing, the regulation of medico-legal autopsies in diverse nations around the world and the publication of international guidelines or best practices elaborated by International Scientific Societies. Finally, in "The Future" section, innovative robotized and advanced microscopy systems and techniques, including their possible use in the bio-medicolegal field, are reported, which should lead to the improvement and standardization of the autopsy methodology, thereby achieving a more precise identification of natural and traumatic pathologies.

  11. "Blind spots" in forensic autopsy: improved detection of retrobulbar hemorrhage and orbital lesions by postmortem computed tomography (PMCT).

    Science.gov (United States)

    Flach, P M; Egli, T C; Bolliger, S A; Berger, N; Ampanozi, G; Thali, M J; Schweitzer, W

    2014-09-01

    The purpose of this study was to correlate the occurrence of retrobulbar hemorrhage (RBH) with mechanism of injury, external signs and autopsy findings to postmortem computed tomography (PMCT). Six-teen subjects presented with RBH and underwent PMCT, external inspection and conventional autopsy. External inspection was evaluated for findings of the bulbs, black eye, raccoon eyes and Battle's sign. Fractures of the viscerocranium, orbital lesions and RBH were evaluated by PMCT. Autopsy and PMCT was evaluated for orbital roof and basilar skull fracture. The leading manner of death was accident with central regulatory failure in cases of RBH (31.25%). Imaging showed a high sensitivity in detection of orbital roof and basilar skull fractures (100%), but was less specific compared to autopsy. Volume of RBH (0.1-2.4ml) correlated positively to the presence of Battle's sign (pforensically relevant head trauma. PMCT is an excellent tool in detecting and quantifying morphological trauma findings particularly in the viscerocranium, one of the most relevant "blind spots" of classic autopsy. PMCT was superior in detecting osseous lesions, scrutinizing autopsy as the gold standard. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  12. State Education Finance and Governance Profile: South Carolina

    Science.gov (United States)

    Conrad, Zachary

    2010-01-01

    This article presents the state education finance and governance profile of South Carolina. In the state of South Carolina, the population in 1990 was estimated at 3,486,310, and as of July 2008 the population was estimated at 4,479,800. In terms of education funding, the K-12 education General Fund appropriation is $2,441,044,733 for Fiscal Year…

  13. The South Carolina Collaborative Undergraduate HBCU Student Summer Training Program

    Science.gov (United States)

    2016-02-01

    spend a day at MUSC to give presentations and meet with Student Fellows. & HCC Annual Spring Research Symposium—thematic re- search conferences are...1] AWARD NUMBER: W81XWH-12-1-0043 TITLE: The South Carolina Collaborative Undergraduate HBCU Student Summer Training Program PRINCIPAL...From - To) 1 March 2012 - 30 Nov 2015 4. TITLE AND SUBTITLE The South Carolina Collaborative Undergraduate HBCU Student Summer Training Program

  14. Virtual autopsy by computed tomographic angiography of the fetal heart: a feasibility study.

    Science.gov (United States)

    Votino, C; Cannie, M; Segers, V; Dobrescu, O; Dessy, H; Gallo, V; Cos, T; Damry, N; Jani, J

    2012-06-01

    To determine the feasibility of postmortem computed tomographic (pm-CT) angiography for fetal heart evaluation. Following termination of pregnancy (TOP) or intrauterine fetal death (IUFD) beyond 18 weeks' gestation, 33 fetuses were examined by pm-CT; in eight contrast medium was injected through the umbilical cord and in 25 contrast medium was injected directly into the heart. Logistic regression analysis was used to investigate the effect on the ability to visualize cardiac structures on pm-CT angiography of gestational age at TOP or delivery following IUFD, the time delay between fetal death and examination, the technique used for contrast-medium injection, the presence of cardiac abnormalities and whether or not there was IUFD. The diagnostic accuracy of pm-CT angiography for the evaluation of fetal cardiac structures was also evaluated. Cardiac anatomy including heart situs, the four-chamber view and great vessels could be visualized on pm-CT angiography in 29 out of 33 fetuses (87.9%). Logistic regression analysis showed that the ability to visualize cardiac structures on pm-CT angiography was positively correlated only with contrast medium injected directly into the heart. Twenty-five out of the 33 fetuses underwent conventional autopsy. There were five cases with suspected major cardiac abnormality at prenatal ultrasound and one with a minor cardiac abnormality. In one of these cases, severe leakage into the pleural cavity did not allow for visualization of any heart structure on pm-CT angiography and in another invasive autopsy was declined. In two of the remaining four cases, the findings on pm-CT angiography and invasive autopsy were in agreement, while in two a ventricular septal defect was found on invasive autopsy but not on pm-CT. None of the 27 cases with normal hearts was falsely classified as abnormal using pm-CT angiography. Pm-CT angiography by direct injection into the heart seems to be a feasible method for its evaluation. The extent to which

  15. [Influence of cause of death on body and internal organs weight in perinatal autopsies].

    Science.gov (United States)

    Corrêa, Rosana Rosa Miranda; Rocha, Laura Penna; Petrini, Caetano Galvão; Teixeira, Vicente de Paula Antunes; Castro, Eumenia Costa da Cunha

    2014-01-01

    To evaluate changes in body and internal organ weight of autopsied children in the perinatal period and their relationship with the cause of death. One hundred and fifty three cases of perinatal autopsies performed at a university hospital in Southeastern Brazil ere included. Information about cause of perinatal death, date of autopsy, gestational age, perinatal weight and organ weight was obtained from the autopsy protocols and medical records of the mother and/or the newborn. Four groups of causes of death were defined: congenital malformations, perinatal hypoxia/anoxia, ascending infection and hyaline membrane. Brain, liver, lungs, heart, spleen, thymus and adrenals were analyzed. The weight of children with perinatal hypoxia/anoxi (1,834.6±1,090.1 g versus 1,488 g), hyaline membranes (1,607.2±820.1 g versus 1,125 g) and ascending infection (1,567.4±1,018.9 g versus 1,230 g) was higher than expected for the population. Lung weight was higher in cases with ascending infection (36.6±22.6 g versus 11 g) and lower in cases with congenital malformations (22.0±9.5 g versus 40 g). Spleen weight was higher in children with ascending infection (8.6±8.9 g versus 3.75 g ) and adrenal weight was lower in cases with congenital malformations (3.9±2.1 g versus 5.5 g). Thymus weight was lower in cases with miscellaneous causes (3.7±1.2 g versus 7.5 g) and spleen weight was lower in patients with lung immaturity (0.4±0.1 g versus 1.7 g). All results showed significant differences. This study demonstrates that variations in the weight of children and the weight of their organs are related to the types of cause of perinatal death. These data may contribute to a better interpretation of autopsy findings and their anatomical and clinical relationship.

  16. Environmental Sensitivity Index (ESI) Atlas: North Carolina and South Carolina Digital Data Re-release, 1996 (NODC Accession 0049956)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set comprises an update of the Environmental Sensitivity Indexes (ESI) data for North and South Carolina. ESI data characterize estuarine environments and...

  17. Legal Assistance Preventive Law Series

    Science.gov (United States)

    1994-06-01

    Services Division, North Carolina Department of Human Resources, 325 North Salisbury Street, Raleigh, North Carolina 27611. (Also, request Information...pocketbook. Some models are designed for those whose budget limits them to a lower-cost home. Other models have such higher-priced features as cathedral

  18. A Comparison of Breast and Cervical Cancer Legislation and Screening in Georgia, North Carolina, and South Carolina

    OpenAIRE

    Miles-Richardson, Stephanie; Blumenthal, Daniel; Alema-Mensah, Ernest

    2012-01-01

    We identified legislation (1989–2005) relating to breast and cervical cancer in Georgia, North Carolina, and South Carolina and examined its impact on screening rates for these cancers and on Black-White disparities in screening rates. Legislation was identi-fied using the National Cancer Institute’s (NCI) State Cancer Legislative Database (SCLD) Program. Screening rates were identified using the Centers for Disease Control and Prevention’s Behavioral Risk Factor Surveillance System. Georgia ...

  19. Image-guided virtual autopsy findings of gunshot victims performed with multi-slice computed tomography and magnetic resonance imaging and subsequent correlation between radiology and autopsy findings.

    Science.gov (United States)

    Thali, Michael J; Yen, Kathrin; Vock, Peter; Ozdoba, Christoph; Kneubuehl, Beat P; Sonnenschein, Martin; Dirnhofer, Richard

    2003-12-17

    Because the use of radiology in modern forensic medicine has been, until today, mostly restricted to conventional X-rays, which reduces a 3D body to a 2D projection, a detailed 3D documentation of a gunshot's wound ballistic effects was not possible. The aim of our study was to evaluate whether the progress in imaging techniques over the last years has made it possible to establish an observer-independent and reproducible forensic assessment using multi-slice computed tomography (MSCT) and magnetic resonance imaging (MRI) technologies for the documentation and analysis of gunshot wounds. The bodies of eight gunshot victims were scanned by MSCT and by MRI; the data of these imaging techniques were post-processed on a workstation, interpreted and subsequently correlated with the findings of classical autopsy. With the spiral CT and MRI examinations and the subsequent 2D multi-planar reformation (MPR) and 3D shaded surface display (SSD) reconstruction, the entire gunshot-created complex skull fractures and brain injuries (such as wound channels and deeply-driven bone splinters) could be documented in complete and graphic detail. CT and MRI also documented vital reaction to the gunshot by demonstrating air emboli in the heart and blood vessels and the classic pattern of blood aspiration to the lung. Gunshot residues deposited within and under the skin were visible. In conclusion, we think that the radiological methods of MSCT and MRI have the potential to become a routine "virtual autopsy" tool in the future. Bullets and relevant histological samples from specific sites then might be won in image-guided minimally invasive fashion via percutaneous biopsy. The rapid application of developing radiological methods may lead to new horizons in forensic documentation and intravital as well as postmortem examination.

  20. Tidal Datum Changes Induced by Morphological Changes of North Carolina Coastal Inlets

    Directory of Open Access Journals (Sweden)

    Jindong Wang

    2016-11-01

    Full Text Available In support of the National Oceanic and Atmospheric Administration’s VDatum program, a new version of a tidal datum product for the North Carolina coastal waters has been developed to replace the initial version released in 2004. Compared with the initial version, the new version used a higher resolution grid to cover more areas and incorporated up-to-date tide, bathymetry, and shoreline data. Particularly, the old bathymetry datasets that were collected from the 1930s to the 1970s and were used in the initial version have been replaced by the new bathymetry datasets collected in the 2010s in the new version around five North Carolina inlets. This study aims at evaluating and quantifying tidal datum changes induced by morphological changes over about 40 to 80 years around the inlets. A series of tidal simulations with either the old or new bathymetry datasets used around five inlets were conducted to quantify the consequent tidal datum changes. The results showed that around certain inlets, approximately 10% change in the averaged depth could result in over 30% change in the tidal datum magnitude. Further investigation also revealed that tidal datum changes behind the barrier islands are closely associated with the cross-inlet tidal flux changes.

  1. Preliminary Physical Stratigraphy and Geophysical Data From the USGS Dixon Core, Onslow County, North Carolina

    Science.gov (United States)

    Seefelt, Ellen L.; Gonzalez, Wilma Aleman B.; Self-Trail, Jean M.; Weems, Robert E.; Edwards, Lucy E.; Pierce, Herbert A.; Durand, Colleen T.

    2009-01-01

    In October through November 2006, scientists from the U. S. Geological Survey (USGS) Eastern Region Earth Surface Processes Team (EESPT) and the Raleigh (N.C.) Water Science Center (WSC), in cooperation with the North Carolina Geological Survey (NCGS) and the Onslow County Water and Sewer Authority (ONWASA), drilled a stratigraphic test hole and well in Onslow County, N.C. The Dixon corehole was cored on ONWASA water utility property north of the town of Dixon, N.C., in the Sneads Ferry 7.5-minute quadrangle at latitude 34deg33'35' N, longitude 77deg26'54' W (decimal degrees 34.559722 and -77.448333). The site elevation is 66.0 feet (ft) above mean sea level as determined using a Paulin precision altimeter. The corehole attained a total depth of 1,010 ft and was continuously cored by the USGS EESPT drilling crew. A groundwater monitoring well was installed in the screened interval between 234 and 254 ft below land surface. The section cored at this site includes Upper Cretaceous, Paleogene, and Neogene sediments. The Dixon core is stored at the NCGS Coastal Plain core storage facility in Raleigh. The Dixon corehole is the fourth and last in a series of planned North Carolina benchmark coreholes drilled by the USGS Coastal Carolina Project. These coreholes explore the physical stratigraphy, facies, and thickness of Cretaceous, Paleogene, and Neogene Coastal Plain sediments in North Carolina. Correlations of lithologies, facies, and sequence stratigraphy can be made with the Hope Plantation corehole, N.C., near Windsor in Bertie County (Weems and others, 2007); the Elizabethtown corehole, near Elizabethtown, N.C., in Bladen County (Self-Trail and others, 2004b); the Smith Elementary School corehole, near Cove City, N.C., in Craven County (Harris and Self-Trail, 2006; Crocetti, 2007); the Kure Beach corehole, near Wilmington, N.C., in New Hanover County (Self-Trail and others, 2004a); the Esso#1, Esso #2, Mobil #1, and Mobil #2 cores in Albermarle and Pamlico Sounds

  2. Population Health Metrics Research Consortium gold standard verbal autopsy validation study: design, implementation, and development of analysis datasets

    Directory of Open Access Journals (Sweden)

    Ohno Summer

    2011-08-01

    Full Text Available Abstract Background Verbal autopsy methods are critically important for evaluating the leading causes of death in populations without adequate vital registration systems. With a myriad of analytical and data collection approaches, it is essential to create a high quality validation dataset from different populations to evaluate comparative method performance and make recommendations for future verbal autopsy implementation. This study was undertaken to compile a set of strictly defined gold standard deaths for which verbal autopsies were collected to validate the accuracy of different methods of verbal autopsy cause of death assignment. Methods Data collection was implemented in six sites in four countries: Andhra Pradesh, India; Bohol, Philippines; Dar es Salaam, Tanzania; Mexico City, Mexico; Pemba Island, Tanzania; and Uttar Pradesh, India. The Population Health Metrics Research Consortium (PHMRC developed stringent diagnostic criteria including laboratory, pathology, and medical imaging findings to identify gold standard deaths in health facilities as well as an enhanced verbal autopsy instrument based on World Health Organization (WHO standards. A cause list was constructed based on the WHO Global Burden of Disease estimates of the leading causes of death, potential to identify unique signs and symptoms, and the likely existence of sufficient medical technology to ascertain gold standard cases. Blinded verbal autopsies were collected on all gold standard deaths. Results Over 12,000 verbal autopsies on deaths with gold standard diagnoses were collected (7,836 adults, 2,075 children, 1,629 neonates, and 1,002 stillbirths. Difficulties in finding sufficient cases to meet gold standard criteria as well as problems with misclassification for certain causes meant that the target list of causes for analysis was reduced to 34 for adults, 21 for children, and 10 for neonates, excluding stillbirths. To ensure strict independence for the validation of

  3. Assessing the Impact of Saltwater Intrusion in the Carolinas under Future Climatic and Sea Level Conditions

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The goal of this research is to support coastal decision-makers in North Carolina and South Carolina by providing information about potential future precipitation...

  4. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: North Carolina: WETLANDS (Wetland Polygons)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains vector polygons representing the coastal wetlands for North Carolina. This data set comprises a portion of the ESI data for North Carolina....

  5. Cost-Effectiveness Analysis of the Residential Provisions of the 2015 IECC for South Carolina

    Energy Technology Data Exchange (ETDEWEB)

    Mendon, Vrushali V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Zhao, Mingjie [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Taylor, Zachary T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Poehlman, Eric A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-02-15

    The 2015 IECC provides cost-effective savings for residential buildings in South Carolina. Moving to the 2015 IECC from the 2009 IECC base code is cost-effective for residential buildings in all climate zones in South Carolina.

  6. Literary homecoming as collaboration: Eastern North Carolina Libraries connect with the creative sector

    National Research Council Canada - National Science Library

    Cook, Eleanor I; Tennent, Blythe; Bauer, Margaret

    2011-01-01

    .... With activities in 6 counties located in the mid-coastal region of North Carolina, the program provides a rich opportunity for people of this area to learn about and meet North Carolina artists...

  7. CREEK Project's Oyster Biomass Database for Eight Creeks in the North Inlet Estuary, South Carolina

    Data.gov (United States)

    Baruch Institute for Marine and Coastal Sciences, Univ of South Carolina — A group of eight tidal creeks dominated by oysters, Crassostrea virginica, in North Inlet Estuary, South Carolina, USA were studied using a replicated BACI (Before -...

  8. Hurricane Ophelia Aerial Photography: High-Resolution Imagery of the North Carolina Coast After Landfall

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The imagery posted on this site is of the North Carolina coast after Hurricane Ophelia made landfall. The regions photographed range from Hubert, North Carolina to...

  9. Peat deposits Of Dismal Swamp Pocosins, Camdem, Currituck, Gates, Pasquotank, And Perquimans Counties, North Carolina

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Peat is present in the Dismal Swamp of northeastern North Carolina and southeastern Virginia. In North Carolina the peat is in 4 separate deposits located west,...

  10. 75 FR 15704 - Old Dominion Electric Cooperative; North Carolina Electric Membership Corporation, Complainants v...

    Science.gov (United States)

    2010-03-30

    ... Energy Regulatory Commission Old Dominion Electric Cooperative; North Carolina Electric Membership Corporation, Complainants v. Virginia Electric and Power Company, Respondent; Notice of Complaint March 23...), Old Dominion Electric Cooperative and North Carolina Electric Membership Corporation (Complainants...

  11. Craniometric analysis for estimation of stature in Nepalese population--A study on an autopsy sample.

    Science.gov (United States)

    Shrestha, Rijen; Shrestha, Pramod Kumar; Wasti, Harihar; Kadel, Tulsi; Kanchan, Tanuj; Krishan, Kewal

    2015-03-01

    Establishing the identity of the deceased becomes essential when highly decomposed bodies, mutilated body parts or skeletal remains are recovered from mass fatality sites. In these situations, estimation of stature along with other parameters such as age, sex and race/ethnicity becomes important to establish the biological profile of the deceased. Following the Maoist insurgency in Nepal, there have been numerous discoveries of unidentified human remains in mass graves or otherwise. No systemic studies and anthropological data on the Nepalese population however, is available posing problems in anthropologic evaluation of the remains. The sample of the present study consisted of 200 autopsied cases (148 males and 52 female adult cadavers). During the autopsy, the scalp was reflected after giving a coronal incision extending from one mastoid to the other exposing the cranium in each case. Maximum cranial length (MCL), maximum cranial breadth (MCB), bi-zygomatic breadth (BZB), minimum frontal breadth (MFB) and length of parietal chord (PC) were then measured. Stature was measured as the length of the body from head to heel in centimeters with the heel, buttocks, back of the shoulders and the head in contact with the autopsy table. Linear and stepwise multiple regression models were derived for estimation of stature from cranial measurements. Univariate, bivariate and multivariate regression models show statistically significant correlation between stature and the cranial measurements. The present study opines that the stature estimation from cranial dimensions using multivariate linear regression models is more accurate than those of the univariate and bivariate regression models. This study presents a rare data from Nepalese population that show typical Asian features and thus, is significant from anthropologic and genetic point of view. The study observations further contribute a baseline data bank for forensic pathologists and specialists. Copyright © 2014

  12. Postmortem heart weight modelled using piecewise linear regression in 27,645 medicolegal autopsy cases.

    Science.gov (United States)

    Wingren, Carl Johan; Ottosson, Anders

    2015-07-01

    The interpretation of postmortem heart weight is often difficult, and references for normal heart weight are important. However, to assess the cause of death at a medicolegal autopsy it is also important to have references based on an unselected population of medicolegal autopsy cases with non-natural causes of death (not due directly to disease). We aimed at studying and deriving references for adult heart weight by considering sex, age and body size in cases with an external cause of death. We identified all medicolegal autopsies in Sweden from 1999 to 2013 (n=79,778) and included 27,645 cases. We applied multivariate piecewise linear regression models in three strata of body mass-underweight, normal-/overweight and obesity. We observed that approximately 50% of the variation in heart weight was explained by age, sex and body size. These variables were slightly less important in explaining the variation in heart weight in the underweight and obese compared to in those normal or overweight. Based on the linear regression models we present equations to calculate the predicted heart weight with reference intervals using age, sex, body weight and height. We provide an online heart weight calculator (http://lundforensicmedicine.com) based on these equations. In the forensic interpretation of postmortem heart weights, we suggest that heart weight references derived in cases with an external cause of death is an important complement to references solely based on healthy and normal hearts. Furthermore, the heart weight references presented are derived from a large population, with sufficient numbers for separate models in underweight, normal-/overweight and obese populations. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  13. Cause of death among Ghanaian adolescents in Accra using autopsy data

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    Tettey Yao

    2011-09-01

    Full Text Available Abstract Background There is limited data on adolescent mortality particularly from developing countries with unreliable death registration systems. This calls for the use of other sources of data to ascertain cause of adolescent mortality. The objective of this study was to describe the causes of death among Ghanaian adolescents 10 to 19 years in Accra, Ghana utilizing data from autopsies conducted in Korle Bu Teaching Hospital (KBTH. Findings Out of the 14,034 autopsies carried out from 2001 to 2003 in KBTH, 7% were among adolescents. Of the 882 deaths among adolescents analyzed, 402 (45.6% were females. There were 365 (41.4% deaths from communicable disease, pregnancy related conditions and nutritional disorders. Non-communicable diseases accounted for 362 (41% cases and the rest were attributable to injuries and external causes of morbidity and mortality. Intestinal infectious diseases and lower respiratory tract infections were the most common communicable causes of death collectively accounting for 20.5% of total deaths. Death from blood diseases was the largest (8.5% among the non-communicable conditions followed by neoplasms (7%. Males were more susceptible to injuries than females (χ2 = 13.45, p = .000. At least five out of ten specific causes of death were as a result of infections with pneumonia and typhoid being the most common. Sickle cell disease was among the top three specific causes of death. Among the females, 27 deaths (6.7% were pregnancy related with most of them being as a result of abortion. Conclusions The autopsy data from the Korle-Bu Teaching Hospital can serve as a useful source of information on adolescent mortality. Both communicable and non-communicable diseases accounted for most deaths highlighting the need for health care providers to avoid complacency in their management of adolescents presenting with these diseases.

  14. Plaque-like demyelination in acute disseminated encephalomyelitis (ADEM) - an autopsy case report.

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    Guenther, Angela D; Munoz, David G

    2013-01-01

    The pattern of demyelination in the scant autopsy literature on acute disseminated encephalomyelitis (ADEM) is described as perivenous sleeves. We report an unusual neuropathological presentation of ADEM, also known as postinfectious or perivenous encephalomyelitis. A 19-yearold female patient presented with headache and myalgias, followed by subacute onset of lethargy, confusion, left hemiparesis and dysphasia after an interval of 4 - 5 days. On MRI, extensive subcortical white matter lesions were seen and a diagnosis of ADEM was made after other causes were excluded. The patient received intravenous methylprednisolone and plasma exchange. Neurological symptoms remained stable over the length of the hospital stay (1 month). The patient passed away due to non-neurologic causes. On autopsy, the brain showed extensive, confluent, plaque-like demyelinating lesions with a striking selectivity for the subcortical white matter sparing the U-fibers. No lesions were discernible in the cortex, the deep grey matter, the cerebellum, the spinal cord or the optic nerves on LFB-stained sections. Only one lesion extended to the periventricular area in the right occipital lobe. Some lesions had a scalloped border and foci of inhomogeneous demyelination, suggestion coalescence of smaller lesions. Histologically, all lesions were of the same age, coupling near complete demyelination with relative preservation of axons, along with scant perivascular lymphohistiocytic cuffing, dense infiltration by foamy macrophages, and prominent gliosis. The morphology of individual demyelinating< lesions is indistinguishable from the lesions in a new onset case of multiple sclerosis (MS) and adds to the autopsy literature on overlapping neuropathological findings in ADEM and multiple sclerosis.

  15. Right atrial mural thrombi: An autopsy study of an under-diagnosed complication at an unusual site

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    P Vaideeswar

    2017-01-01

    Full Text Available Background: Right atrial mural thrombi (RAMT are often seen in association with cardiac diseases or foreign bodies. Unusual locations at the flutter isthmus and the atrial appendage prompted us to evaluate our 2-year autopsy data on such thrombi. Materials and Methods: In the 2-year retrospective autopsy, the clinical and autopsy records of patients with RAMT were reviewed, with particular reference to the presence of central venous catheter (CVC, its site of insertion, its type, material and size, its duration of placement, and the drugs infused through the catheter. Results: Of the 940 autopsies performed in 2 years, RAMT was seen in 24 hearts and was related to an insertion of a CVC in 23 patients (95.8%. The risk and/or associated factors for this complication were tunneled and polyethylene catheters, Intensive Care Unit admission, infused drugs, underlying cardiac diseases, and pregnancy. A noteworthy feature was the location of the thrombi in the flutter isthmus in 16 hearts (66.7% and atrial appendage in another six hearts. Localized endocarditis/myocarditis and pulmonary thromboembolism were observed in six and four patients, respectively.Conclusions: This autopsy study, which has a high incidence of catheter-related RAMT, does not reflect the true incidence but reiterates the importance of guided insertion of central venous and prompt recognition of thrombus formation.

  16. A psychological autopsy study of suicide among Inuit in Nunavut: methodological and ethical considerations, feasibility and acceptability.

    Science.gov (United States)

    Chachamovich, Eduardo; Haggarty, Jack; Cargo, Margaret; Hicks, Jack; Kirmayer, Laurence J; Turecki, Gustavo

    2013-01-01

    The increasing global prevalence of suicide has made it a major public health concern. Research designed to retrospectively study suicide cases is now being conducted in populations around the world. This field of research is especially crucial in Aboriginal populations, as they often have higher suicide rates than the rest of the country. This article presents the methodological aspects of the first psychological autopsy study on suicide among Inuit in Nunavut. Qaujivallianiq Inuusirijauvalauqtunik (Learning from lives that have been lived) is a large case-control study, including all 120 cases of suicide by Inuit that occurred in Nunavut between 1 January 2003 and 31 December 2006. The article describes the research design, ethical considerations and strategies used to adapt the psychological autopsy method to Nunavut Inuit. Specifically, we present local social and cultural issues; data collection procedures; and the acceptability, reliability and validity of the method. A retrospective case-control study using the psychological autopsy approach was carried out in 22 communities in Nunavut. A total of 498 individuals were directly interviewed, and medical and correctional charts were also reviewed. The psychological autopsy method was well received by participants as they appreciated the opportunity to discuss the loss of a family member or friend by suicide. During interviews, informants readily identified symptoms of psychiatric disorders, although culture-specific rather than clinical explanations were sometimes provided. Results suggest that the psychological autopsy method can be effectively used in Inuit populations.

  17. A psychological autopsy study of suicide among Inuit in Nunavut: methodological and ethical considerations, feasibility and acceptability

    Directory of Open Access Journals (Sweden)

    Eduardo Chachamovich

    2013-03-01

    Full Text Available Introduction. The increasing global prevalence of suicide has made it a major public health concern. Research designed to retrospectively study suicide cases is now being conducted in populations around the world. This field of research is especially crucial in Aboriginal populations, as they often have higher suicide rates than the rest of the country. Objective. This article presents the methodological aspects of the first psychological autopsy study on suicide among Inuit in Nunavut. Qaujivallianiq Inuusirijauvalauqtunik (Learning from lives that have been lived is a large case-control study, including all 120 cases of suicide by Inuit that occurred in Nunavut between 1 January 2003 and 31 December 2006. The article describes the research design, ethical considerations and strategies used to adapt the psychological autopsy method to Nunavut Inuit. Specifically, we present local social and cultural issues; data collection procedures; and the acceptability, reliability and validity of the method. Method. A retrospective case-control study using the psychological autopsy approach was carried out in 22 communities in Nunavut. A total of 498 individuals were directly interviewed, and medical and correctional charts were also reviewed. Results. The psychological autopsy method was well received by participants as they appreciated the opportunity to discuss the loss of a family member or friend by suicide. During interviews, informants readily identified symptoms of psychiatric disorders, although culture-specific rather than clinical explanations were sometimes provided. Results suggest that the psychological autopsy method can be effectively used in Inuit populations.

  18. A psychological autopsy study of suicide among Inuit in Nunavut: methodological and ethical considerations, feasibility and acceptability

    Science.gov (United States)

    Chachamovich, Eduardo; Haggarty, Jack; Cargo, Margaret; Hicks, Jack; Kirmayer, Laurence J.; Turecki, Gustavo

    2013-01-01

    Introduction The increasing global prevalence of suicide has made it a major public health concern. Research designed to retrospectively study suicide cases is now being conducted in populations around the world. This field of research is especially crucial in Aboriginal populations, as they often have higher suicide rates than the rest of the country. Objective This article presents the methodological aspects of the first psychological autopsy study on suicide among Inuit in Nunavut. Qaujivallianiq Inuusirijauvalauqtunik (Learning from lives that have been lived) is a large case-control study, including all 120 cases of suicide by Inuit that occurred in Nunavut between 1 January 2003 and 31 December 2006. The article describes the research design, ethical considerations and strategies used to adapt the psychological autopsy method to Nunavut Inuit. Specifically, we present local social and cultural issues; data collection procedures; and the acceptability, reliability and validity of the method. Method A retrospective case-control study using the psychological autopsy approach was carried out in 22 communities in Nunavut. A total of 498 individuals were directly interviewed, and medical and correctional charts were also reviewed. Results The psychological autopsy method was well received by participants as they appreciated the opportunity to discuss the loss of a family member or friend by suicide. During interviews, informants readily identified symptoms of psychiatric disorders, although culture-specific rather than clinical explanations were sometimes provided. Results suggest that the psychological autopsy method can be effectively used in Inuit populations. PMID:23539438

  19. [Grading the level of suspicion in criminal proceedings, restrictions of the proportionality principle and veto options in forensic autopsies].

    Science.gov (United States)

    Czerner, Frank

    2010-01-01

    The article deals with two topics: determination of the necessary level of suspicion for an internal post-mortem examination pursuant to Section 87 (German) Code of Criminal Procedure and options of the family to object to the forensic autopsy. The level of suspicion required in this case is to be regarded as very low, even below that of the initial suspicion, because a detailed opinion as to any third-party fault can only be given after completion of the autopsy. The individual concerned does not have a right to oppose a forensic autopsy while still alive. The same applies to the family. Other than in clinical autopsies, the interest in prosecution is to be considered the higher good to be protected, because at the time of deciding a homicide cannot be ruled out and only an internal examination can furnish the necessary evidence. Consequently, it is appropriate. Contrary to the opinion often expressed in the literature, one cannot infer from the provisions of Sections 87 subs. 4, 33 subs. 3 Code of Criminal Procedure and Section 103 subs. 3 Basic Law that the family of the deceased has a right to be informed or heard. This can only be changed by the legislator in an amendment to the autopsy law.

  20. Sudden death after chest pain: feasibility of virtual autopsy with postmortem CT angiography and biopsy.

    Science.gov (United States)

    Ross, Steffen G; Thali, Michael J; Bolliger, Stephan; Germerott, Tanja; Ruder, Thomas D; Flach, Patricia M

    2012-07-01

    To determine the potential of minimally invasive postmortem computed tomographic (CT) angiography combined with image-guided tissue biopsy of the myocardium and lungs in decedents who were thought to have died of acute chest disease and to compare this method with conventional autopsy as the reference standard. The responsible justice department and ethics committee approved this study. Twenty corpses (four female corpses and 16 male corpses; age range, 15-80 years), all of whom were reported to have had antemortem acute chest pain, were imaged with postmortem whole-body CT angiography and underwent standardized image-guided biopsy. The standard included three biopsies of the myocardium and a single biopsy of bilateral central lung tissue. Additional biopsies of pulmonary clots for differentiation of pulmonary embolism and postmortem organized thrombus were performed after initial analysis of the cross-sectional images. Subsequent traditional autopsy with sampling of histologic specimens was performed in all cases. Thereafter, conventional histologic and autopsy reports were compared with postmortem CT angiography and CT-guided biopsy findings. A Cohen κ coefficient analysis was performed to explore the effect of the clustered nature of the data. In 19 of the 20 cadavers, findings at postmortem CT angiography in combination with CT-guided biopsy validated the cause of death found at traditional autopsy. In one cadaver, early myocardial infarction of the papillary muscles had been missed. The Cohen κ coefficient was 0.94. There were four instances of pulmonary embolism, three aortic dissections (Stanford type A), three myocardial infarctions, three instances of fresh coronary thrombosis, three cases of obstructive coronary artery disease, one ruptured ulcer of the ascending aorta, one ruptured aneurysm of the right subclavian artery, one case of myocarditis, and one pulmonary malignancy with pulmonary artery erosion. In seven of 20 cadavers, CT-guided biopsy