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Sample records for cards g-1 tld-100

  1. Mensuration of equivalent dose with personal dosemeters and instruments of radiological protection in the new operative magnitudes ICRU, for external fields of beta radiation. Part I. Study of the homogeneity of the response personal dosemeters leaves (cards G-1, TLD-100), in radiation fields of Co{sub 60}; Medicion de dosis equivalente con dosimetros personales e instrumentos de proteccion radiologica en las nuevas magnitudes operativas ICRU, para campos de radiacion beta externos. Parte I. Estudio de la homogeneidad de la respuesta dosimetros personales (tarjetas G-1, TLD-100), en campos de radiacion de Co{sub 60}

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    Alvarez R, J.T. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    1994-01-15

    A sample of 40 composed personal dosemeters by cards model: G-l, (each card is made up of two TLD-100 crystals encapsulated in teflon), Harshaw trademark; those personal dosemeters present a free window and another with a filter of A1 of 171.7 mg cm{sup -2} of mass thickness.The objective of the work is to select of this sample of 40 personal dosemeters a population with the same stocking and standard deviation. The technique used is that of comparison of stockings, (ANOVA; Variance Analysis, when samples of the same one were had size; and/or GLM, Widespread Lineal Models, when the samples were of different size), by means of the use of those Duncan statistics, SNK, Tukey, Gabriel; the results are validated proving the kindness of adjustment of the experimental data to a Normal distribution by means of the Shapiro-Wilks statistics.The experimental design used consists on a test of two vias: a via is the variable card with two levels, (crystal 1 and 2), the other via is the variable irradiation position with four levels, (LS=left superior, SR= right superior, LI= left Inferior, IR = right inferior). The irradiations carried out in blocks of four personal dosemeters in a gamma radiation beam range of Cobalt 60; carrying out three repetitions of the design. With object of proving the homogeneity of the filter of A1 in those personal dosemeters the experimental design was executed for those cards without personal dosemeters.They were also carried out tests of stockings to the readings of bottom and sensibility of the reader equipment, (Harshaw, model marks 2271), certain that doesn{sup t} exist differences for sequence of reading, but if in the stockings of the sensibility, (they were 4 different populations). The responses of the dosemeters were corrected subtracting him the reading correspondence of bottom and by sensibility of the reader equipment before subjecting them to the tests of stockings mentioned. Of the results of the tests of stockings for the cards with

  2. Determination of the TLD-100 physical parameters; Determinacion de parametros fisicos del TLD-100

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    Paucar J, J.; Picon C, C. [Instituto Nacional de Enfermedades Neoplasicas. INEN. Av. Angamos Este 2520, Lima 34 (Peru)

    1998-12-31

    This study was realized in the Physics service at the Radiotherapy Department of the National Institute of Neoplasic Diseases in Lima, Peru, it was determined the activation energy, the kinetic order and the frequency factor of the fifth peak of the TLD-100 thermoluminescent spectra using different algorithms. This was carried out in parallel with the implementation and design of a software and an interface associated with the Tl lecturer which allows a semiautomatic control for a thermoluminescent lecturer process. (Author)

  3. Thermoluminescent relative efficiencies of TLD-100 for nitrogen ions respect of gamma radiation; Eficiencias termoluminiscentes relativas de TLD-100 para iones de nitrogeno respecto de radiacion gamma

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    Concha S, K. [UNAM, Facultad de Ciencias, 04510 Mexico D.F. (Mexico); Avila, O. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico); Gamboa de Buen, I. [ICN-UNAM, 04510 Mexico D.F. (Mexico); Rodriguez V, M.; Buenfil, A.E.; Ruiz T, C.; Brandan, M.E. [IFUNAM, 04510 Mexico D.F. (Mexico)

    2004-07-01

    The purpose of this work is to measure the thermoluminescent relative efficiency of those TLD-100 dosemeters irradiated with nitrogen ions with respect to the gamma radiation of {sup 60} Co, in function of the linear energy transfer (LET). Two energy of such nitrogen ions were selected that has the same value from LET when impacting in the dosemeters but with E{sub 1} energy (4.8 MeV) and E{sub 2} (9.95 MeV) smaller and greater respectively that the energy of the Bragg peak. (Author)

  4. Verification or treatment planning system of radiotherapy using TLD-100; Verificacion de los sistemas de planificacion de tratamiento de radioterapia empleando TLD-100

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    Pinuela, J., E-mail: jcpinuela@hotmail.co [Hospital Central de Maracay (Venezuela, Bolivarian Republic of). Servicio de Radioterapia

    2010-07-01

    The evaluation of the treatment planning system (TPS) used in radiotherapy Precise Plan, was carried out using TLD-100 dosimeters, comparing the dose obtained with an ionization chamber. The TLD-100 were calibrated using secondary standard of SSDL, selecting dosimeters which had a standard deviation less than 1% for dosimeter calibration and less than 5% for dosimeter of field, for the tests conducted in TPS, The Alderson Phantom was used to evaluate the wedge and bolus, and Lucy 3D allowed us to evaluate correspondence of CT numbers, volume expansion, beam shaping, precise dose and beam weigh assignment. It was observed that the results of Lucy 3D were within the values expected except the volume expansion process with more than 10% difference, the evaluation of beam modulators systems with wedges and bolus as beam shaping yielded values within the expected with variations less than 5% and to assess the supply of specific doses, it was observed that the values obtained were precise and accurate since the same variation was less than 0.5% for the test. The importance of assessing the TPS lies in our country there is no procedure to verify that system and these tests provide a basis for future comparisons. (author)

  5. Quality control of the breast cancer treatments on Hdr brachytherapy with TLD-100

    Energy Technology Data Exchange (ETDEWEB)

    Torres H, F. [Universidad de Cordoba, Materials and Applied Physics Group, 230002 Monteria, Cordoba (Colombia); De la Espriella V, N. [Universidad de Cordoba, Grupo Avanzado de Materiales y Sistemas Complejos, 230002 Monteria, Cordoba (Colombia); Sanchez C, A., E-mail: franciscotorreshoyos@yahoo.com [Universidad de Cordoba, Departamento de Enfermeria, 230002 Monteria, Cordoba (Colombia)

    2014-07-01

    An anthropomorphic Phantom, a female trunk, was built with a natural bone structure and experimental material coated, glycerin and water-based material called JJT to build soft tissue equivalent to the muscle of human tissue, and a polymer (styrofoam) to build the lung as critical organ to simulate the treatment of breast cancer, with high dose rate brachytherapy (Hdr) and sources of Ir-192. The treatments were planned and calculated for the critical organ: Lung, and injury of 2 cm in diameter in breast with Micro Selectron Hdr system and the software Plato Brachytherapy V 14.1 of the Nucletron (Netherlands) which uses the standard protocol of radiotherapy for brachytherapy treatments. The dose experimentally measured with dosimeters TLD-100 LiF: Mg; Ti, which were previously calibrated, were placed in the same positions and bodies mentioned above, with less than 5% uncertainty. The reading dosimeters was carried out in a Harshaw TLD 4500. The results obtained for calculated treatments, using the standard simulator, and the experimental with TLD-100, show a high concordance, as they are on average a ± 1.1% making process becomes in a quality control of this type of treatments. (Author)

  6. The stabilization of the sensitivity of TLD-100 by combined UV irradiation and thermal annealing

    Science.gov (United States)

    Necmeddin Yazýcý, A.; Öztürk, Zihni

    2001-06-01

    In this study, a new experimental annealing procedure, which is based on combined UV(253.7+/-1.2 nm) irradiation and thermal annealing (300 °C for 30 min followed by 90 °C for 6 h) is introduced to reduce the large standard deviation (8-20% between consecutive ten cycles) observed after standard annealing (400 °C for 1 h followed by 100 °C for 10 min) on the main dosimetric peak 5 of thermoluminescence dosimeter TLD-100. The results indicate that when the combined UV irradiation and thermal annealing protocol is applied, the standard deviation in the area of the main dosimetric peak 5 is reduced to less than 10% for the consecutive ten-cycle operation.

  7. Characterization of TLD-100 micro-cubes for use in small field dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    Peña-Jiménez, Salvador, E-mail: zoid-9861@yahoo.com.mx; Gamboa-deBuen, Isabel, E-mail: gamboa@nucleares.unam.mx [Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Av. Universidad 3000, 04510 DF (Mexico); Lárraga-Gutiérrez, José Manuel, E-mail: jose.larraga.gtz@gmail.com, E-mail: amanda.garcia.g@gmail.com; García-Garduño, Olivia Amanda, E-mail: jose.larraga.gtz@gmail.com, E-mail: amanda.garcia.g@gmail.com [Laboratorio de Física Médica, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Av. Insurgentes Sur 3877, 14269 DF (Mexico)

    2014-11-07

    At present there are no international regulations for the management of millimeter scale fields and there are no suggestions for a reference detector to perform the characterization and dose determination for unconventional radiation beams (small fields) so that the dosimetry of small fields remains an open research field worldwide because these fields are used in radiotherapy treatments. Sensitivity factors and reproducibility of TLD-100 micro-cubes (1×1×1 mm3) were determinate irradiating the dosimeters with a 6 MV beam in a linear accelerator dedicated to radiosurgery at the Instituto Nacional de Neurología y Neurocirugía (INNN). Thermoluminescent response as a function of dose was determined for doses in water between 0.5 and 3 Gy and two field sizes (2×2 cm2 and 10×10 cm2). It was found that the response is linear over the dose range studied and it does not depend on field size.

  8. Use of TLD-100 to verify a dosimetric method for total electron skin irradiation

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    Mesa, F.; Sosa, M. [Physics Institute, University of Guanajuato, Loma del Bosque 103, Lomas del Campestre, 37150 Leon, Guanajuato (Mexico)

    2007-07-01

    Full text: A clinical dosimetric method for generating a homogeneous field of radiation around of patients under treatment of total skin electron irradiation and its verification using thermoluminescent dosimetry is presented. The irradiations were performed utilizing a 6 MeV electron beam generated by a Varian Clinac 21EX linear accelerator installed in the oncology unit of the IMSS-Tl hospital in Leon. Levels of radiation for diverse adjustment performed in the treatment planning system of the lineal accelerator and registered to different treatment distances using a computerized water phantom system were studied. A large batch of TLD-100 chips calibrated in terms of air-kerma rate to the standard treatment distance and positioned in an anthropomorphic Alderson Random Phantom was used. Dose verification and comparison with the measurements made with the computerized system were analyzed. A single field electron beam for treatment of total skin irradiation was implemented. Preliminary results indicate that the levels of dose homogeneities were larger than 90% for distances up to 3.0 m. The results suggest that the method developed is a reliable for delivering an electron beam with significantly homogeneity for these treatments. Analyses and results of both thermoluminescent and computerized dosimetric system calibrations are also presented. (Author)

  9. Mensuration of equivalent dose with personal dosemeters and instruments of radiological protection in the new operative quantities ICRU, for external fields of beta radiation. Part II. I study of the angular response of personal dosemeters TLD-100 in secondary patron fields of beta radiation ({sup 90}Sr / {sup 90}Y); Medicion de dosis equivalente con dosimetros personales e instrumentos de proteccion radiologica en las nuevas magnitudes operativas ICRU, para campos de radiacion beta externos. Parte II. Estudio de la respuesta angular de dosimetros personales TLD-100 en campos patrones secundarios de radiacion beta ({sup 90}Sr/{sup 90}Y)

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    Alvarez R, J.T. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    1994-01-15

    The objective of this work is to carry out one of the possible ones test type for personal dosemeters TLD, under the recomendations of the ICRU 39, ICRU 43 and the draft of the norm ISO 6980,(1992), with the purpose of verifying the capacity of these detectors to carry out the operative unit: H' (0.07;{alpha}). Since H' (O. 07;{alpha}) this defined one in an expanded field, one of these tests type consist on determining the angular response of these detectors. 20 personal dosemeters TLD-100 was used, (card marks: Harshaw, Model: G-1, with two glasses of TLD-100 absorbed in teflon; the portadosemeters has two windows, a free one and another with a filter of Pb of 171.0 mg cm{sup -2}); these dosemeters they were previously selected, [to see, {sup S}tudy of the Homogeneity of the response of Personal Dosemeters (Cards G-l, TLD-100) in Radiation of Countrysides of {sup 60}Co{sup ,} J.T. Alvarez R. Technician Report GSR/IT/0001/94].The irradiations to effectued in secondary countryside of radiation beta of {sup 90}Sr/{sup 90}Y. The study was undertaken by means of an experimental design of blocks random that contemplate the following variables: intensity of the radiation source, (1850 MBq and 74 MBq); position of irradiation, (four positions); incidence of angle of the radiation (0, 15, 30, 45, 60 and 75 grades) and the absorbed dose in air, (0.005, 0.010, 0.020, 0.050 and 0.100 Gy). Then null hypothesis it was to suppose that there was not difference among the stockings of each treatment, to used the statistical of Duncan to carry out tests of stockings at a level of significance of 5%.These tests of stockings throw the following results in those variables of the experimental design: The irradiations carried out so much with the source pattern secondary of {sup 90}Sr/{sup 90}Y of 1850 MBq and of 74 MBq, they are equivalent reason why they can be used indistinctly. The responses of each one of the glasses of the card are strongly anisotropic for each glass

  10. Relative thermoluminescent efficiencies proton/gamma and helium/gamma of high temperature peaks in TLD-100 dosemeters; Eficiencias termoluminiscentes relativas proton/gamma y helio/gamma de picos de alta temperatura en dosimetros TLD-100

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    Flores M, E.; Avila, O.; Rodriguez V, M. [ININ, 52750 La Marquesa, Estado de Mexico (Mexico); Massillon, J.L.G.; Buenfil A, E.; Ruiz T, C.; Brandan, M.E. [IFUNAM, 04500 Mexico D.F. (Mexico); Gamboa De Buen, I. [ICN-UNAM, 04500 Mexico D.F. (Mexico)

    2007-07-01

    This work presents measures of relative thermoluminescent efficiency of those high temperature peaks of TLD-100 dosemeters exposed to protons of 1.5 MeV and to helium nuclei of 3 and 7.5 MeV. A rigorous reading and of deconvolution protocol was used for the calculation of the TL efficiencies. Additionally an Excel program that facilitated the deconvolution adjustment process of the glow curves was elaborated. (Author)

  11. TLD-100 glow-curve deconvolution for the evaluation of the thermal stress and radiation damage effects

    CERN Document Server

    Sabini, M G; Cuttone, G; Guasti, A; Mazzocchi, S; Raffaele, L

    2002-01-01

    In this work, the dose response of TLD-100 dosimeters has been studied in a 62 MeV clinical proton beams. The signal versus dose curve has been compared with the one measured in a sup 6 sup 0 Co beam. Different experiments have been performed in order to observe the thermal stress and the radiation damage effects on the detector sensitivity. A LET dependence of the TL response has been observed. In order to get a physical interpretation of these effects, a computerised glow-curve deconvolution has been employed. The results of all the performed experiments and deconvolutions are extensively reported, and the TLD-100 possible fields of application in the clinical proton dosimetry are discussed.

  12. Obtention of thermoluminescent efficiencies by means of irradiation of TLD-100 dosemeters with proton beams helium and carbon; Obtencion de eficiencias termoluminiscentes mediante irradiacion de dosimetros TLD-100 con haces de protones, helios y carbon

    Energy Technology Data Exchange (ETDEWEB)

    Avila, O.; Rodriguez V, M.; Aviles, P.; Gamboa de Buen, I.; Buenfil, A.E.; Ruiz T, C.; Brandan, M.E. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    2002-07-01

    In this work, the advances of a serial of measurements of relative efficiency thermoluminescent of heavy charged particles (PCP) with respect to gamma radiation for TLD-100, dosemeters of LiF: Mg,Ti manufactured by the Harshaw-Bicron company are reported. The PCP are essentials in the implementation of dosimetry associated with medical applications. The measurements before gamma radiation were carrying out using the Vickrad irradiator of the National Institute of Nuclear Research at dose of 1.663 Gy. The measures which are reported about protons, helium and carbon were realized using the Pelletron accelerator of the Physics Institute of the UNAM. (Author)

  13. Comparison of the responses of TLD-100 and radiochromic films exposed to X-rays of low energy in a radiodiagnostic clinical treatment

    Energy Technology Data Exchange (ETDEWEB)

    Castro, M.; Mesa, F.; Sosa, M. [Physics Institute, University of Guanajuato, Loma del Bosque 103, Lomas del Campestre, 37150 Leon, Guanajuato (Mexico)

    2007-07-01

    Full text: In this work a comparison of the responses of a TLD-100 and a radiochromic film exposed to a low energy X-ray beam is presented. X-rays in the range of 20 to 120 KV from a clinical machine at the radiodiagnostic unit of the IMSS-Tl hospital in Leon were used. The processes of calibration of both the TLD-100 and the radiochromic films are also discussed. (Author)

  14. Thermoluminescence of pure LiF and Lif (TLD-100) irradiated at room temperature; Termoluminiscencia en LiF puro y LiF dosimetrico (TLD-100), irradiados a temperatura ambiente

    Energy Technology Data Exchange (ETDEWEB)

    Sagastibelza Chivite, F.

    1980-07-01

    The thermoluminescence of pure LiF and LiF (TLD-100) crystals irradiated at room temperature with x - or gamma-rays has been studied up to 460 degree centigree. For most of the glow peaks found the kinetics, preexponential factors and activation energies have been determined. These parameters have been obtained by means of the isothermal method. The study of the thermal annealing of the radiation induced F and Z centres has allow to show that there is a correlation among the glow peaks and the annealing stages of these centres. It is concluded that the F and Z - centres play the role of recombination centres for halogen interstitial atom thermally released from traps. Light emission occurs in this recombination. (Author) 120 refs.

  15. Response of TLD-100 LiF dosimeters for X-rays of low energies; Respuesta de dosimetros de TLD-100 de LiF para rayos X de bajas energias

    Energy Technology Data Exchange (ETDEWEB)

    Bonzi, E. V.; Mainardi, R. T. [Universidad Nacional de Cordoba, Facultad de Matematica, Astronomia y Fisica, Av. Haya de la Torre y Av. Medina Allende s/n, Ciudad Universitaria, X5016LEA Cordoba (Argentina)

    2011-10-15

    In diverse practical applications as the existent in radiological clinics, industrial facilities and research laboratories, the solid state dosimeters are used for the measure of the different types of ionizing radiations. At the present time dosimeters are manufactured with different types of materials that present thermoluminescent properties, to the effects of determining the absorbed radiation dose. Under these conditions, the radiation dose is determined integrated in all the range of energies of the beam of X-rays, since it assumes that the response of these dosimeters is lineal with the energy of the photons or radiant particles. Because interest exists in advancing in the development of a determination method in the way of the X-rays spectrum emitted by a tube of those used in diagnostic or therapy, we have measured the response of TLD-100 LiF dosimeters for low energies, minor at 60 keV, for a several group of these dosimeters. (Author)

  16. Relative thermoluminescent efficiencies proton/gamma and helium/gamma of peaks of high temperature in TLD-100 dosemeters; Eficiencias termoluminiscentes relativas proton/gamma y helio/gamma de picos de alta temperatura en dosimetros TLD-100

    Energy Technology Data Exchange (ETDEWEB)

    Flores M, E. [UNAM, Facultad de Ciencias, 04510 Mexico D.F. (Mexico)

    2007-07-01

    The increase of the applications of ion beams in radiotherapy treatments has generated interest in the study of the thermoluminescent materials (TL) that allow to determine the applied doses. A way to quantify the TL response from these materials to ions is by means of the relative thermoluminescent efficiency. In the group of Thermoluminescent dosimetry of the Institute of Physics of the UNAM (IFUNAM) the thermoluminescent response of the TLD-100 dosemeters has been studied, which present a glow curve characteristic with several peaks that correspond to traps and luminescent centers in the material. The stable peaks know each other as 4, 5, 6a, 6b, 7, 8, 9 and 10. The efficiencies should be measured using the response so much to the radiation of interest (in this case protons and helium ions) as the response to gamma radiation. In previous works with ions of low energy taken place in the Pelletron accelerator of the IFUNAM was only measured the TL efficiency for the peak 5 and the total signal. It had not been possible to measure the efficiency of the peaks of high temperature (6a-10) because, for the gamma radiation, the peaks of high temperature show very small signals; however, recently Massillon carries out measures of efficiency TL of peaks of high temperature for ions of intermediate energy using a protocol special of reading and of deconvolution that allows to measure the signals coming from the peaks of high temperature. In this work is implemented this same protocol to complete the study of TL efficiencies at low energy of protons and helium and to determine if the values of efficiency depend on the used reading protocol. For it is reported it measures of the relative efficiency of the peaks of high temperature from the TLD-100 exposed to protons of 1.5 MeV and nuclei of helium of 3 and 7.5 MeV. (Author)

  17. Measure of the attenuation curve of a beam of X-rays with TLD-100 dosimeters of LiF; Medicion de la curva de atenuacion de un haz de rayos X con dosimetros TLD-100 de LiF

    Energy Technology Data Exchange (ETDEWEB)

    Bonzi, E. V.; Mainardi, R. T. [Universidad Nacional de Cordoba, Facultad de Matematica, Astronomia y Fisica, Av. Haya de la Torre y Av. Medina Allende s/n, Ciudad Universitaria, Cordoba (Argentina); Germanier, A. [Ministerio de Ciencia y Tecnologia, Ceprocor, Unidad de Estudios Fisicos, Alvarez de Arenas 230, X5004AAP Barrio Juniors, Cordoba (Argentina); Delgado, V. [Universidad Complutense de Madrid, Departamento de Fisica Medica, Ciudad Universitaria, 28040 Madrid (Spain)

    2011-10-15

    The attenuation curve of a beam of X-rays represents the beam intensity in function of the attenuator thickness interposed between the source and the detector. To know with the major possible precision the attenuation curve is indispensable in procedures of spectral reconstruction. Their periodic measuring also offers valuable information on the correct operation of a tube of X-rays, diagnostic or therapy, when not have a specific detector for that activity. In this work was measured the attenuation curve of a tube of X-rays operated to 50 kV and 0.5 ma, using existent elements in any diagnostic or therapy laboratory with radiations. In the measures commercial aluminum foil was used, bent until 24 times and thermoluminescent dosimeters TLD 100 - LiF. Also, for comparison, was measured this attenuation curve with an ionization chamber brand Capintec model 192. Was determined by X-rays fluorescence the composition of the aluminium foil, since the present elements in the alloy can to affect the form of the attenuation curve. It is interesting to observe that these elements are in very low proportion (ppm) that they do not alter the attenuation capacity of the pure aluminium. Finally in a precision balance we weigh a big piece (30 cm x 100 cm) of aluminium foil and we obtained the thickness in g/c m2. It is possible to obtain attenuation curves of a beam of X-rays, with a high precision procedure and reproducibility. The use of TLD-100 dosimeters of LiF or similar makes that this activity was also quick and simple. (Author)

  18. Thermoluminescent response of dosemeters TLD-100 exposed to distinct baker protocols, irradiation and reading; Respuesta termoluminiscente de dosimetros TLD-100 sujetos a distintos protocolos de horneado, irradiacion y lectura

    Energy Technology Data Exchange (ETDEWEB)

    Estrada E, D

    2002-07-01

    The interest that motivated the realization of this work is the opposing discrepancy among the values of the efficiency thermoluminescent of heavy charged particles (PCP) regarding gamma radiation ({eta}{sub PCP}, {gamma}) reported in different works and gathered recently for Horowitz (Ho 01). The measures of relative thermoluminescent efficiency have importance in relation to the dosimetry associated to medical therapy with heavy charged particle. The measurement of {eta}{sub PCP}, {gamma} depends of multiple experimental factors. To understand this dependence it was quantified the effect of using different procedures experimental in the estimate of the relative thermoluminescent efficiency of dosemeters TLD-100 (LiF: Ti; Mg) for protons of 3 MeV regarding gamma rays of {sup 60}Co ({eta}{sub PCP}, {gamma}), varying the lot, the presentation, the one baked and the team reader. When was used the same global procedure values they were obtained for ({eta}{sub PCP}, {gamma}) inside the interval [0.30, 0.58] for the peak 5 and [0.35, 0.76] for the total thermoluminescent signal (Tl). At the use different equipment, baked and lot are obtained maximum differences of 30%, 12% and 6% respectively in the values of ({eta}{sub PCP}, {gamma}) for the peak 5, and 25%, 28% and 7% for the total Tl signal. The changes more significant of 36% and 44% for peak 5 and total signal respectively are obtained when changing the presentation of the dosemeter. As a complementary investigation it was studied the distribution of the Tl signal of each peak in the deconvolution of the curve of brightness with regard to the total signal in exposed dosemeters to high fluence of protons (1x10{sup 10} p/cm{sup 2}) varying the experimental protocol. It was found that the distribution of the Tl signal has a difference of the order of 5% when changing the used reading team. It was observed that the contribution of the peak 5 regarding the total signal are preserved when changing baked and that it

  19. Investigation of the ionisation density dependence of the glow curve characteristics of LIF:MG,TI (TLD-100)

    Science.gov (United States)

    Horowitz, Y. S.; Horowitz, A.; Oster, L.; Marino, S.; Datz, H.; Margaliot, M.

    2008-01-01

    The dependence of the shape of the glow curve of LiF:Mg,Ti (TLD-100) on ionisation density was investigated using irradiation with 90Sr/90Y beta rays, 60 and 250 kVp X rays, various heavy-charged particles and 0.2 and 14 MeV neutrons. Special attention is focused on the properties of high-temperature thermoluminescence; specifically, the behaviour of the high-temperature ratio (HTR) of Peaks 7 and 8 as a function of batch and annealing protocol. The correlation of Peaks 7 and 8 with average linear-energy-transfer (LET) is also investigated. The HTR of Peak 7 is found to be independent of LET for values of LET approximately >30 keV µm−1. The behaviour of the HTR of Peak 8 with LET is observed to be erratic, which suggests that applications using the HTR should separate the contributions of Peaks 7 and 8 using computerised glow curve deconvolution. The behaviour of the HTR following neutron irradiation is complex and not fully understood. The shape of composite Peak 5 is observed to be broader following high ionisation alpha particle irradiation, suggesting that the combined use of the HTR and the shape of Peak 5 could lead to improved ionisation density discrimination for particles of high LET. PMID:18667402

  20. Effects of annealing on glow peak parameters of LiF:Mg,Ti (TLD-100) dosimetry material

    Energy Technology Data Exchange (ETDEWEB)

    Piters, T.M. [Universidad de Sonora (Mexico). Centro de Investigacion en Fisica; Boss, A.J.J.; Burg, B. van der [Delft University of Technology (Netherlands). Interfaculty Reactors Institute

    1996-12-31

    Computerised glow curve analysis has been used to examine the dependence of the peak parameters of LiF:Mg,Ti (TLD-100) on the pre-irradiation annealing procedure in the temperature range 353 K to 673 K. The intensities of the main peaks 1, 2, 3, 4 and 5 as well as the activation energies and frequency factors were found to vary strongly with the pre-irradiation low temperature annealing. The trends in the changes of the glow curves with respect to peaks 2 and 5 could be explained by the defect reaction equation MgV {r_reversible} (MgV){sub 2} {r_reversible} (MgV){sub 3} {r_reversible} precipitates, and an additional assumption that the traps responsible for peak 2 react during read out with MgV and (MgV){sub 2}. The `precipitation` process was found to be frozen in at temperatures lower than 373 K. The influences of variations in the cooling rate in the annealing procedure on the glow curve shape are discussed. It was found that for accurate dosimetry the cooling applied in the annealing procedure is not a very critical factor for high cooling rates (> 1 K.s{sup -1}) but may be a very critical factor for low cooling rates (< 0.08 K.s{sup -1}). (author).

  1. Quality control for thermoluminescent dosemeters TLD-100 de Li F: Mg, Ti for high dose rate treatments using Ir-192 sources in breast, esophagus and bronchus; Control de calidad con dosimetros thermoluminiscentes TLD-100 de Li F: Mg, Ti para tratamientos de alta tasa de dosis com fuentes de Ir-192 en canceres de seno, esofago y bronchio

    Energy Technology Data Exchange (ETDEWEB)

    Torres, F. [Universidad Nacional de Colombia, Bogota (Colombia)]. E-mail: franciscotorreshoyos@yahoo.com; Plazas, M.C. [Instituto Nacional de Cancerologia, Bogota (Colombia); Cavadia, W. [Universidad de Cordoba (Colombia)

    2004-07-01

    Rods - shaped, TLD - 100, LiF: Mg,Ti thermoluminescence dosimeters are used to check duality control during breast, esophagus and bronchus cancer treatments with high rate dose and Ir -192 source. We conclude that the specificity dose in prescription points is in agreement with parameters given in international protocols. (author)

  2. Comparative study of thermoluminescent properties of LiF: Mg, Cu, P, LiF: Mg, Ti and TLD-100 irradiated with X-rays; Estudio comparativo de las propiedades termoluminiscentes de LiF: Mg, Cu, P, LiF: Mg, Ti y TLD-100 irradiados con rayos X

    Energy Technology Data Exchange (ETDEWEB)

    Azorin, J.; Rivera, T.; Gonzalez, P.; Ortega, X.; Ginjaume, M. [Universidad Autonoma Metropolitana-Iztapalapa, 09000 Mexico D.F. (Mexico)

    2000-07-01

    The thermoluminescent properties (Tl) of LiF: Mg, Cu, P, and LiF: Mg, Ti, were investigated both developed in Mexico and comparing them with the properties of TLD-100 when they are exposure to X-rays. The Tl curve of LiF: Mg, Cu, P exhibited two peaks at 200 and 300 Centigrade. Its response Tl in function of dose resulted linear in the interval of 0.5 Gy until 5 Gy and its sensitivity to X-ray was around 25 times greater that of the TLD-100. Also it was measured the Tl response of the three materials in function of photon energy. The results showed that LiF: Mg, Cu, P has potential to be used as X-ray dosemeter. (Author)

  3. A comparative evaluation of luminescence detectors: RPL-GD-301, TLD-100 and OSL-AL2O3:C, using Monte Carlo simulations

    Science.gov (United States)

    Benali, A.-H.; Medkour Ishak-Boushaki, G.; Nourreddine, A.-M.; Allab, M.; Papadimitroulas, P.

    2017-07-01

    The luminescent dosimeters are widely used in clinical practice, for the monitoring of patient dose in external radiation therapy. Three of the most common dosimeter categories are the thermoluminescence (TLDs), the radiophotoluminescence (RPLs) and the optically stimulated luminescence (OSLs), with similar physical processes on their properties. The aim of the present study is to compare and evaluate the dosimetric properties of three specific luminescent detectors namely: a) RPL glass dosimeter, commercially known as GD-301, b) lithium fluoride TLD-100 (LiF:Mg,Ti) and c) carbon-doped aluminum oxide (Al2O3:C). For this purpose, Monte Carlo simulations were applied, using the MCNP5 code to estimate the responses of these dosimeters in terms of absorbed dose, output factor, the angular and energy dependence. In the present study, we found that the differences between the output factors were less than ± 4.2% for all detector materials RPLGD, TLD and OSLD. The variations in sensitivity for angles up to ± 80 degrees from the central axis of the beam were approximately 0.5%, 0.8% and 1.5% for the TLD-100, GD-301 and Al2O3:C, respectively. The energy dependence of the RPL and OSL dosimeters are stated as less than a 2.2%, and within 5.8% for TLD.

  4. Proton/gamma relative thermoluminescence efficiencies of LiF:Mg,Cu,P+PTFE prepared at ININ and TLD-100H

    Energy Technology Data Exchange (ETDEWEB)

    Avila, O.; Gonzalez, P.; Murillo, G. [Departamento de Fisica, ININ, Carretera Mexico-Toluca s/n, Ocoyoacac 52750, Estado de Mexico (Mexico)

    2009-10-15

    Properties of LiF:Mg,Cu,P+PTFE dosemeters developed at ININ have been investigated in order to evaluate their performance compared to those of equivalent commercial dosemeters. In this work both LiF:Mg,Cu,P+PTFE and TLD-100H pellets were exposed to low fluence 3 MeV protons and to low dose gamma radiation to evaluate experimental proton/gamma efficiencies. Gamma irradiation was performed using the Vic krad irradiator at ININ at varying doses between 25 and 500 mGy. For proton irradiation the Tandem Van de Graaff accelerator at ININ was used. Dosemeters were placed on a holder inside a scattering chamber where protons impinge on a gold target and scatter in all directions. The holder allows for several angular positions so that dosemeters receive proton fluence between 10{sup 6} and 10{sup 1}0 p/cm{sup 2}. Experimental efficiency values found for LiF:Mg,Cu,P+PTFE and TLD-100H were 0.18 +- 03 and 0.23 +- 0.03, respectively. These results allow to confirm the reliability of the dosemeters developed at ININ. (Author)

  5. Comparison of the calculated absorbed dose using the Cadplan™ treatment planning software and Tld-100 measurements in an Alderson-Rando phantom for a bronchogenic treatment

    Energy Technology Data Exchange (ETDEWEB)

    Gutiérrez Castillo, J. G., E-mail: jggc59@hotmail.com [Departamento de Física, Hospital de Oncología, IMSS, CMN Siglo XXI, Cuauhtémoc 330 Col. Doctores (Mexico); Álvarez Romero, J. T., E-mail: trinidad.alvarez@inin.gob.mx, E-mail: fisarmandotorres@gmail.com, E-mail: victor.tovar@inin.gob.mx; Calderón, A. Torres, E-mail: trinidad.alvarez@inin.gob.mx, E-mail: fisarmandotorres@gmail.com, E-mail: victor.tovar@inin.gob.mx; M, V. Tovar, E-mail: trinidad.alvarez@inin.gob.mx, E-mail: fisarmandotorres@gmail.com, E-mail: victor.tovar@inin.gob.mx [SSDL, Departamento de Metrología ININ, Salazar, Estado de México 15245 (Mexico)

    2014-11-07

    To verify the accuracy of the absorbed doses D calculated by a TPS Cadplan for a bronchogenic treatment (in an Alderson-Rando phantom) are chosen ten points with the following D's and localizations. Point 1, posterior position on the left edge with 136.4 Gy. Points: 2, 3 and 4 in the left lung with 104.9, 104.3 and 105.8 Gy, respectively; points 5 and 6 at the mediastinum with 192.4 and 173.5 Gy; points 7, 8 and 9 in the right lung with 105.8, 104.2 and 104.7 Gy, and 10 at posterior position on right edge with 143.7 Gy. IAEA type capsules with TLD 100 powder are placed, planned and irradiated. The evaluation of the absorbed dose is carried out a curve of calibration for the LiF response (nC) {sup vs} {sup DW}, to several cavity theories. The traceability for the DW is obtained with a secondary standard calibrated at the NRC (Canada). The dosimetric properties for the materials considered are determined from the Hounsfield numbers reported by the TPS. The stopping power ratios are calculated for nominal spectrum to 6 MV photons. The percent variations among the planned and determined D in all the cases they are < ± 3%.

  6. Evaluation of the Entrance Skin Dose in Animals Undergoing Diagnostic Radiology Using LiF, Mg, Ti Thermoluminescence Dosimetry (TLD-100

    Directory of Open Access Journals (Sweden)

    Sedigheh Sina

    2016-06-01

    Full Text Available Introduction According to the International Commission on Radiological Protection publication numbers 60 and 21, the environmental control standards should ensure human and other species protection to a desirable degree. Since application of radiographic procedures in Veterinary Medicine has increased significantly, in this study, we aimed to evaluate the entrance skin dose to the animals (e.g., dogs, cats, horses, and birds undergoing diagnostic radiology. Materials and Methods The entrance skin dose to the animals in different radiology procedures were estimated through a indirect estimation using the output of X-ray tubes and b direct measurement using LiF:Mg, Ti  (TLD-100  thermoluminescence dosimeter. Regression analysis was performed for comparison of the two methods. The animals included in this study were cats, dogs, small birds, horses, parrots, and chough. Results The dose received by the animals varied from 20 mGy to 1189.2 mGy, depending on the animal thickness, focal spot to surface distance, imaging technique, and animal type. Conclusion Optimized procedures are suggested for obtaining high-quality images, with a reasonably low dose imposed to the animals.

  7. ON HF (TLD -100) PHOSPHORS

    African Journals Online (AJOL)

    2005-08-19

    Aug 19, 2005 ... radiation causes trapping of freed electrons or. (holes) at lattice ... These properties make TL detectors very useful tools ... The electrons in the traps must be excited to the conduction band (CB) that is, transition of A and B for TL to take place. These electrons then undergo migration in the conduction band ...

  8. Dosimetry for small fields in stereotactic radiosurgery using gafchromic MD-V2-55 film, TLD-100 and alanine dosimeters.

    Directory of Open Access Journals (Sweden)

    Guerda Massillon-J L

    Full Text Available This work investigated the suitability of passive dosimeters for reference dosimetry in small fields with acceptable accuracy. Absorbed dose to water rate was determined in nine small radiation fields with diameters between 4 and 35 mm in a Leksell Gamma Knife (LGK and a modified linear accelerator (linac for stereotactic radiosurgery treatments. Measurements were made using Gafchromic film (MD-V2-55, alanine and thermoluminescent (TLD-100 dosimeters and compared with conventional dosimetry systems. Detectors were calibrated in terms of absorbed dose to water in (60Co gamma-ray and 6 MV x-ray reference (10×10 cm(2 fields using an ionization chamber calibrated at a standards laboratory. Absorbed dose to water rate computed with MD-V2-55 was higher than that obtained with the others dosimeters, possibly due to a smaller volume averaging effect. Ratio between the dose-rates determined with each dosimeter and those obtained with the film was evaluated for both treatment modalities. For the LGK, the ratio decreased as the dosimeter size increased and remained constant for collimator diameters larger than 8 mm. The same behaviour was observed for the linac and the ratio increased with field size, independent of the dosimeter used. These behaviours could be explained as an averaging volume effect due to dose gradient and lack of electronic equilibrium. Evaluation of the output factors for the LGK collimators indicated that, even when agreement was observed between Monte Carlo simulation and measurements with different dosimeters, this does not warrant that the absorbed dose to water rate in the field was properly known and thus, investigation of the reference dosimetry should be an important issue. These results indicated that alanine dosimeter provides a high degree of accuracy but cannot be used in fields smaller than 20 mm diameter. Gafchromic film can be considered as a suitable methodology for reference dosimetry. TLD dosimeters are not

  9. Personal dosimetry TLD 100 in orthopedic surgeons exposed to ionizing radiation in Bogota - Colombia; Dosimetria personal TLD 110 en medicos ortopedistas expuestos a radiacion ionizante en Bogota - Colombia

    Energy Technology Data Exchange (ETDEWEB)

    Sierra C, B. Y.; Jimenez, Y. [Universidad Nacional de Colombia, Departamento de Fisica, Grupo de Fisica Medica, Carrera 45 No. 26-85, Bogota (Colombia); Plazas, M. C. [Hospital Universitario Fundacion Santa Fe de Bogota, Instituto de Oncologia Carlos Ardila Lulle, Calle 119, No. 7-90, 220246 Bogota (Colombia); Eslava S, J. [Universidad Nacional de Colombia, Instituto de Investigaciones Clinicas, Grupo Equidad en Salud, Carrera 45 No. 26-85, Bogota (Colombia); Groot R, H., E-mail: brigith.sierra@gmail.com [Universidad de los Andes, Laboratorio de Genetica Humana, Carrera 1 No. 18A -12, Bogota (Colombia)

    2014-08-15

    Orthopedic surgeons should be considered as professionals occupationally exposed to ionizing radiation, for using C arc (fluoroscope) an equipment of X type radiation emission, during surgical procedures for imaging generation. Some health institutes, use of C arc under uncontrolled circumstances, such a lack of dosimetry control, incomplete or absence of personnel protective elements and protective measures, which in turn, lead to a high exposition to the personnel. Materials and methods. Study of double match cohort by age and gender, was conducted, in four health institutions of second and third level of attention in Bogota city. Personal dosimetry measurements with TLD-100 dosimetry crystals in both cohorts and environmental dosimetry in each of operation rooms used for orthopedic procedures, were carry out during six months of follow up. Dosimetry crystals were read in a Harshaw 4500 - Bicron equipment, in the Medical Physics Laboratory of National University of Colombia. Results. Dosimetry measurements are compatibles with those of occupationally exposed personnel 3.44 mSv/6 m CI 95% (1.66-3.99), even does not overpass ICRP recommendations, are higher as were expect at the beginning of the study. The median of effective accumulative dose in thorax is 3,4 mSv CI 95% (1,66-3,99), higher in comparison with neck value 2,7 mSv CI 95% (1,73-3,80) and hand dosimetry 1,42 mSv CI 95% (0,96-2,34). Conclusions: Orthopedic surgeons should be considered occupational exposed to ionizing radiation, who has to accomplish to the radiological protection measures, dosimetric follow up and maintenance of the used X ray equipment. It was confirm throughout this study that dosimetry shows higher levels as expected at the beginning of the study, compatible with occupationally exposed personnel. (Author)

  10. TL response of single crystal TLD-100 to 70 eV: 5 keV electrons and comparison with TSEE glow curves

    Energy Technology Data Exchange (ETDEWEB)

    Lasky, J.B.; Moran, P.R.

    1976-01-01

    A ''TL effective'' energy-range relationship was found which agrees with the universal curve above 2 keV but becomes nearly constant at about 300/sup 0/A for energies between 1 keV and 100 eV. The glow curve shape obtained from single crystal TLD-100, after irradiation with 70 eV to 30 keV electrons, is essentially the same as that obtained after irradiation with cesium ..gamma..-rays, (i.e. TL emitted from bulk of sample) as long as (1) the dose is well below saturation and (2) irradiations are performed on freshly cleaved crystals or vacuum annealed crystals. This result shows that there is no intrinsic difference between TL traps near the surface and in the bulk. Irradiation with electron energies less than 1 keV results in the TL signal being emitted from the same region from which TSEE electrons are emitted. The usual TSEE glow curve, found by other investigators, is different from the TL glow curve obtained from vacuum annealed crystals. However, if the TL sample is given the same ''standard annealing'' as is customary in TSEE experiments, the TL glow curve obtained after irradiation with low energy electrons is altered and there is then good agreement between this TL glow curve and the TSEE curve found by others. This altered glow curve is a result of hydroxyl ions which diffuse into the sample during annealing. The TL efficiency was comparable to cesium ..gamma..-rays for 30-5 keV electrons, decreased rapidly between 5 and 1 keV and remained constant at about 20% of the efficiency of cesium ..gamma..-rays below 1 keV. Half of this decrease in efficiency can be attributed to the higher LET of low energy electrons. The cause for the remaining decrease is not known but it may have its origin in the same mechanism proposed to account for the large range of low energy electrons.

  11. Application of the Cavity theory in the calibration of the powder TLD-100 for energies of {sup 60} Co, {sup 137} Cs, {sup 192} Ir and RX 50, 250 k Vp; Aplicacion de la Teoria de la Cavidad en la calibracion de polvo TLD-100 para energias de {sup 60} Co, {sup 137} Cs, {sup 192} Ir y RX 50, 250 kVp

    Energy Technology Data Exchange (ETDEWEB)

    Loaiza C, S.P. [UAEM, Programa de Maestria en Fisica Medica, 50180, Toluca, Estado de Mexico (Mexico); Alvarez R, J.T. [ININ, 52750, Ocoyoacac, Estado de Mexico (Mexico)]. e-mail: sandraplc_04@yahoo.com.mx

    2006-07-01

    A powder lot TLD-100 (LiF:Mg,Ti) in absorbed dose terms in water D{sub w} for the following radiation sources: {sup 60} Co, {sup 137} Cs and RX 50 and 250 k Vp is calibrated; to continuation is made a lineal interpolation of the TLD response in function of the effective energy of the sources to calibrate a source of {sup 192} Ir. The calibration of those fields in D{sub w} are carried out with aid of the Bragg-Gray cavity theory, the one which finds implicit in the following protocols: IAEA-TRS 398 for the {sup 60} Co and the AAPM TG61 for X Rays of 50 and 250 k Vp. Additionally the AAPM protocol TG43 to determine the D{sub w} in function of the kerma intensity S{sub k} in the case of the {sup 137} Cs is used. The calibration curves for the response of the TLD-100 R{sub TLD} vs D{sub w}, corresponding to each one of the sources already mentioned are constructed. The R{sub TLD} vs D{sub w} by least heavy square by means of a second order polynomial that corrects the supralineality of the response is adjusted. The curves are validated by lack of LOF adjustment and by the Anderson Darling normality test. Later the factors of sensitivity (F{sub s}) for the sources of {sup 192} Ir: Micro Selectron and Vari Source are interpolated, used respectively in the A and B hospitals for treatments of brachytherapy of high dose rate (HDR), the expanded uncertainties associated to the D{sub w} and F{sub s} are also determined. Finally, an acrylic phantom and a couple of capsules are already sent to the hospitals mentioned, to verify a nominal D{sub w} of 2 Gy, in a case an underestimate in 5.5% in the imparted D{sub w} and in other an overestimation in a range of -1.5 to -8.0% was obtained. The obtained results in this work establish the bases for the development of a national dosimetric quality control program for brachytherapy of HDR with sources of {sup 192} Ir. (Author)

  12. Dosimetric evaluation of the response of the TLD-100 dosemeters in the IMRT technique by 'Step and Shoot'; Evaluacion dosimetrica de la respuesta de los dosimetros TLD-100 en la tecnica de IMRT por 'Step and Shoot'

    Energy Technology Data Exchange (ETDEWEB)

    Vasquez, J. [Fundacion Clinica Valle del Lili, A.A. 020338, Cali (Colombia); Benavides, S.O. [Depto. de Fisica, Universidad del Valle, A.A. 25360, Cali (Colombia)

    2005-07-01

    We show the results of the dosimetry response of LiF thermoluminescent crystals: TLD-100, where they were radiated in a linear accelerator Siemens Primus Hl using the Intensity Modulated Radiation Therapy (IMRT) by step and shoot technique. Previous to the crystals calibration and response evaluation, the acceptation procedures recommended by the TG-53 protocol for validation of the technique were carried out. The planning system utilized was the Theraplan Plus 3.8, using the algorithm of Pencil Kernel. The register and verification system was Lantis 5.2. The response curve of dose versus charge was obtained from the readings of the TLD in a Harshaw 3500. The crystals were radiated in a Bench- Marck phantom with doses previously determined by using ionization chambers for square radiation fields, in a beam with a 0.68 TPR20,10 corresponding to 6 MV of energy. We compare the response of these through of radiation of segmented fields in a Anthropomorphic phantom and the calculated doses by the planning system. The results obtained in the crystals response show deviations less than 5 % between the measured dose and the calculated dose in the zones of low gradient. It allows its implementation like routine control of quality by IMRT. (Author)

  13. Characterization of TLD-100 in powders for dosimetric quality control of {sup 192} Ir sources used in brachytherapy of high dose rate; Caracterizacion de TLD-100 en polvo para control de calidad dosimetrico de fuentes de Ir{sup 192} usadas en braquiterapia de alta tasa de dosis

    Energy Technology Data Exchange (ETDEWEB)

    Loaiza C, S.P

    2007-07-01

    The Secondary Standard Dosimetric at the National Institute of Nuclear Research (ININ) calibrated a lot of powdered TLD-100 (LiF:Mg,Ti) in terms of absorbed dose to water D{sub w} for the energy of: {sup 60}Co, {sup 137C}s, X rays of 250 and 50 kVp. Later on, it is carried out an interpolation of the calibration for the energy of the {sup 192}Ir. This calibration is part of a dosimetric quality control program, to solve the problems of traceability for the measurements carried out by the users of {sup 192}Ir sources employed in the treatments of High Dose Rate Brachytherapy (HDR) at the Mexican Republic. The calibrations of the radiation beams are made with the following protocols: IAEA TRS-398 for the {sup 60}Co for D{sub w}, using a secondary standard ionization chamber PTW N30013 calibrated in D{sub w} by the National Research Council (NRC, Canada). AAPM TG-43 for D{sub w} in terms of the strength kerma Sk, calibrating this last one quantity for the {sup 137}Cs radioactive source, with a well chamber HDR 1000 PLUS traceable to the University of Wisconsin (US). AAPM TG-61 for X ray of 250 and 50 kVp for D{sub w} start to Ka using field standard a Farmer chamber PTW 30001 traceable to K for the Central Laboratory of Electric Industries (CLEI, France). The calibration curves (CC) they built for the response of the powder TLD: R{sub TLD} vs D{sub w}: For the energy of {sup 60}Co, {sup 137}Cs, X rays of 250 and 50 kVp. Fitting them with the least square method weighed by means of a polynomial of second grade that corrects the supra linearity of the response. iii. Each one of the curves was validated with a test by lack of fitting and for the Anderson Darling normality test, using the software MINITAB in both cases. iv. The sensibility factor (F{sub s}) for each energy corresponds to the slope of the CC, v. The F{sub s} for the two {sup 192}Ir sources used are interpolated: one for a Micro Selectron source and the other one a Vari Source source. Finally, a couple of

  14. Use of MCNP to compare the response of dose deposited in the TLD 100, TLD 600 and TLD 700 in radiation fields due to {sup 60}Co and {sup 241}AmBe source; Uso do MCNP para comparacao das respostas de dose depositada nos TLD 100, TLD 600 e TLD 700 em campos de irradiacao devido a fontes de {sup 60}Co e {sup 241}AmBe

    Energy Technology Data Exchange (ETDEWEB)

    Cavalieri, Tassio A.; Castro, Vinicius A.; Siqueira, Paulo T.D., E-mail: tassio.cavalieri@usp.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2012-08-15

    The successes of Boron Neutron Capture Therapy (BNCT) depend on the ability to deliver an adequate irradiation field to the target cells. Neutron beams used in BNCT are mostly driven from reactors and therefore, not only have a neutron energy range which far exceeds the thermal region but also do have a great gamma component. Beam characterization and dosimetry are consequently one of the essential procedures to be overcome to properly apply this technique. One of the methods currently used in mixed field (field containing both neutron and gamma) characterization, lies on the use of a pair of detectors with distinct responses to each beam component. But this technique needs to be better understood of how each thermoluminescent dosimeter (TLD) behaves in a mixed field or in a pure field. This work presents the results of a set of simulations performed in order to analyze the response of three ordinary types of TLDs - TLD 100, TLD 600 and TLD 700 - submitted to different irradiation fields from a Cobalt source and an Americium-Beryllium source inside a paraffin disk. And is also a possible method for performing the selection and calibration of theses TLDs. (author)

  15. Payment Cards

    Directory of Open Access Journals (Sweden)

    Kantnerová Liběna

    2016-09-01

    Full Text Available The aim of this paper is to analyze the use of payment cards in retail in the Czech Republic from the side of clients (buyers and the side of sellers. Questionnaires for clients examine satisfaction with cards and the service connected with them. Sellers’ satisfaction with the profit and function of cards is analyzed. The data indicated that 92% of the 352 respondents in South Bohemia had a payment card and more than 35% had more than one card. In retail, 70% of sellers had a payment terminal.

  16. Calibration of TLD-100 powder for energies of {sup 60} Co, {sup 137} Cs, {sup 192} Ir and RX of 250, 50 kV{sub p} in absorbed dose in water with dosimetric quality control purposes for brachytherapy of high dose rate; Calibracion de polvo TLD-100 para energias de {sup 60} Co, {sup 137} Cs, {sup 192} Ir y RX de 250, 50 kVp en dosis absorbida en agua con fines de control de calidad dosimetrico para braquiterapia de alta tasa de dosis

    Energy Technology Data Exchange (ETDEWEB)

    Loaiza C, S.P. [Programa de Maestria en Fisica Medica, Universidad Autonoma del Estado de Mexico, Paseo Tollocan S/N, esquina con Jesus Carranza, Colonia Moderna de la Cruz, 50180 Toluca, Edo. de Mexico (Mexico); Alvarez R, J.T. [Laboratorio Secundario de Calibracion Dosimetrica LSCD, Departamento de Metrologia, ININ, Carretera Federal Mexico Toluca S/N, La Marquesa, 52750 Ocoyoacac, Edo. de Mexico (Mexico)

    2006-07-01

    To help solve the traceability and quality control dosimetric problems for the users of {sup 192} Ir sources in the Mexican Republic, the Secondary Standard Dosimetric Laboratory at ININ to calibrated a batch of powder TLD- 100 (LiF: Mg,Ti) in terms of absorbed dose to water D{sub w} for the following radiation sources: {sup 60} Co, {sup 137C}s and RX 250 and 50 k Vp. Later on, the calibration is interpolated to obtain the {sup 192} Ir. The calibration radiation field is carried out with the following protocols: For the {sup 60} Co, IAEA TRS 398 protocol employing a secondary standard Farmer chamber PTW N30013, calibrated on D{sub w} at the NRC (Canada). For {sup 137} Cs the AAPM TG 43 protocol is used, in terms of air kerma strength S{sub k} determined by the air kerma K{sub a}, measured with a secondary standard chamber type thimble NE2611 traceable to the NIST (USA). For Rays X 250 and 50 k Vp, the protocol AAPM TG 61 using a tertiary standard Farmer chamber PTW 30001, with traceability to the LCIE (France) on air kerma K{sub a}. The calibration curves are built for the TLD response R{sub TLD} vs D{sub w}, they are fitted by means of a least squares fit technique with a second degree polynomial that corrects the supra linearity response. The curves are validated by the lack of fit test, and the Anderson Darling normality test. Later on, the sensibility factors are interpolated for the sources of {sup 192} Ir: Micro Selectron and Vari Source. Two capsules are sent to two hospitals to verify a nominal D{sub w} = 2 Gy, in the first one an underestimate of the D{sub w} is obtained, and in other one an overestimation is presented. Finally, the expanded uncertainty associated to D{sub w} and the F{sub s} are calculated. (Author)

  17. Playing the Smart Card.

    Science.gov (United States)

    Zuzack, Christine A.

    1997-01-01

    Enhanced magnetic strip cards and "smart cards" offer varied service options to college students. Enhanced magnetic strip cards serve as cash cards and provide access to services. Smart cards, which resemble credit cards but contain a microchip, can be used as phone cards, bus passes, library cards, admission tickets, point-of-sale debit…

  18. Wallet Card

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CMS Office of Information Products and Data Analysis, OIPDA, produces the CMS Wallet Card as a quick reference statistical summary on annual CMS program and...

  19. Smart Card

    OpenAIRE

    Floarea NASTASE

    2006-01-01

    Reforms in electronic business have presented new opportunities to use smart card technology as an enabling tool. The network-centric applications, where resources are located throughout the Internet and access to them is possible from any location, require authenticated access and secured transactions. Smart cards represent an ideal solution: they offers an additional layer of electronic security and information assurance for user authentication, confidentiality, non-repudiation, information...

  20. Smart Card

    Directory of Open Access Journals (Sweden)

    Floarea NASTASE

    2006-01-01

    Full Text Available Reforms in electronic business have presented new opportunities to use smart card technology as an enabling tool. The network-centric applications, where resources are located throughout the Internet and access to them is possible from any location, require authenticated access and secured transactions. Smart cards represent an ideal solution: they offers an additional layer of electronic security and information assurance for user authentication, confidentiality, non-repudiation, information integrity, physical access control to facilities, and logical access control to an computer systems.

  1. A smart card based student card system

    OpenAIRE

    2009-01-01

    M.Sc. A Smart Card looks like a normal plastic card that we use every day, but its capabilities and advantages are huge. Inside the card there is a small microprocessor capable of doing operations on data. With memory available on the card, data can be stored in a safe and secure location. This card can be used for various applications and is a big improvement on all of its predecessors. These applications can be anything from SIM cards in a cell phone to credit cards and cards used for ac...

  2. Smart Cards and Card Operating Systems

    NARCIS (Netherlands)

    Hartel, Pieter H.; Bartlett, J.; de Jong, Eduard K.

    The operating system of an IC card should provide an appropriate interface to applications using IC cards. An incorrect choice of operations and data renders the card inefficient and cumbersome. The design principles of the UNIX operating system are most appropriate for IC card operating system

  3. Resolving Multiple Stellar Populations in G1

    Science.gov (United States)

    Gregg, Michael

    2017-08-01

    The most luminous and massive compact stellar system in the Local Group is G1, a satellite of M31. It has been speculated that G1 is the remnant nucleus of a tidally stripped dwarf elliptical galaxy. As such, G1 is key to understanding both the evolution of dwarf galaxies and the hierarchical assembly of bright spirals. Recently, new U-B-V-I broad band imaging techniques have revealed multiple stellar populations in Milky Way globular clusters. We propose to obtain new deep WFC3/UVIS F336W and F814W images, to be combined with archival WFC3 data, to probe the star formation and enrichment history of G1. This study will yield new and definitive insights into the origin and evolution of G1, the relationship of globular clusters to dwarf galaxies, and the formation of luminous spirals like M31 and the Milky Way.

  4. FRENCH PROTOCOL CARDS

    CERN Multimedia

    Human Resources Division

    2000-01-01

    Senior officials, holders of FRENCH PROTOCOL cards (blue cards) due to expire on 31.12.2000, are requested to return these cards and those of family members, for extension to: Bureau des cartes, Bât 33.1-009/1-015 Should the three spaces for authentication on the back of the card be full, please enclose two passport photographs for a new card. In the case of children aged 14 and over, an attestation of dependency and a school certificate should be returned with the card.

  5. FRENCH PROTOCOL CARDS

    CERN Multimedia

    Division du Personnel

    1999-01-01

    Senior officials, holders of FRENCH PROTOCOL cards (blue cards) due to expire on 31.12.1999, are requested to return these cards and those of family members, for extension to:Bureau des cartes, bâtiment 33.1-025Should the 3 spaces for authentication on the back of the card be full, please enclose 2 passport photographs for a new card.In the case of children aged 14 and over, an attestation of dependency and a school certificate should be returned with the card.Personnel DivisionTel. 79494/74683

  6. Print a Bed Bug Card - (Single Cards)

    Science.gov (United States)

    Two sets of business-card-sized lists of tips for recognizing bed bugs and the signs of an infestation, including a photo of bed bugs to assist identification. One card is for general use around home or office, the other for travelers.

  7. CERNET Interface Card

    CERN Multimedia

    1978-01-01

    Homegrown networking technology pre-dating the internet. This is a CERNnet card developed and built at CERN. There was a lot of space on the card between the components, so the engineers decided to put their portraits on it.

  8. CMS Wallet Card

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CMS Wallet Card is a quick reference statistical summary on annual CMS program and financial data. The CMS Wallet Card is available for each year from 2004...

  9. Smart card technology

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, R.A.

    1992-09-01

    This report describes smart card techonology and applications, including the use of smart cards as smart badges. The paper illustrates that smart cards are designed with security features, which makes them suitable for security applications. But smart cards also provide multiple functions, so they can support additional applications. The goal of this paper is to inform about the technology, and to inspire thought about possible applications that would benefit if a smart badge were implemented.

  10. Computer Data Punch Cards

    CERN Multimedia

    Those card are printed with minimal layout aids for the formatting of FORTRAN programs, plus extra guidelines every ten columns suggesting a generic tabular data layout. A punch card is a piece of stiff paper that can be used to contain digital information represented by the presence or absence of holes in predefined positions. Punched cards were used for specialized unit record machines, organized into semiautomatic data processing systems, used punched cards for data input, output, and storage. Furthermore many new digital computers started to used punched cards.

  11. REPLACEMENT OF FRENCH CARDS

    CERN Multimedia

    Human Resources Division

    2001-01-01

    The French Ministry of Foreign Affairs has informed the Organization that it is shortly to replace all diplomatic cards, special cards and employment permits ('attestations de fonctions') now held by members of the personnel and their families. Between 2 July and 31 December 2001, these cards are to be replaced by secure, computerized equivalents. The old cards may continue to be used until 31 December 2001. For the purposes of the handover, members of the personnel are asked to go to the cards office (33/1-015), taking the following documents for themselves and members of their families already in possession of a French card : A recent identity photograph in 4.5 cm x 3.5 cm format, The French card in their possession, an A4 photocopy of the same French card, certified by the cards office as being a true copy. Those members of the personnel whose cards (and/or cards belonging to members of their families) are shortly due to expire, or have recently done so, are also requested to take these items to the c...

  12. REPLACEMENT OF FRENCH CARDS

    CERN Multimedia

    HR/SOC

    2001-01-01

    The French Ministry of Foreign Affairs has informed the Organization that it is shortly to replace all diplomatic cards, special cards and employment permits ('attestations de fonctions') now held by members of the personnel and their families. Between 2 July and 31 December 2001, these cards are to be replaced by secure, computerized equivalents. The old cards may continue to be used until 31 December 2001. For the purposes of the handover, members of the personnel must go personally to the cards office (33/1-015), in order to fill in a 'fiche individuelle' form, taking the following documents for themselves and members of their families already in possession of a French card : A recent identity photograph in 4.5 cm x 3.5 cm format. The French card in their possession. An A4 photocopy of the same French card, certified by the cards office as being a true copy. Those members of the personnel whose cards (and/or cards belonging to members of their families) are shortly due to expire, or have recently done...

  13. REPLACEMENT OF FRENCH CARDS

    CERN Multimedia

    Human Resources Division; Cards.Service@cern.ch

    2001-01-01

    The French Ministry of Foreign Affairs is currently replacing all diplomatic cards, special cards and employment permits («attestations de fonctions») held by members of the personnel and their families. These cards are replaced by secure, computerized equivalents. The old cards may no longer be used after 31 December 2001. For the purposes of the handover, members of the personnel must go personally to the cards office (33/1-015) between 8h30 and 12h30, in order to fill in a «fiche individuelle» form, taking the following documents for themselves and members of their families already in possession of a French card : A recent identity photograph in 4.5 cm x 3.5 cm format, the French card in their possession, an A4 photocopy of the same French card, certified by the cards office as being a true copy. Those members of the personnel whose cards (and/or cards belonging to members of their families) are shortly due to expire, or have recently done so, are also requested...

  14. CERN access cards

    CERN Multimedia

    HR Department

    2007-01-01

    Holders of CERN access cards are reminded that the card is an official document. It is important to carry it with you at all times when you are on the site. This applies also to those on standby duty who are called out for emergency interventions. As announced in Weekly Bulletin 13/2006, any loss or theft of access cards must be declared to the competent external authorities.

  15. The Future of Smart Cards.

    Science.gov (United States)

    Fickes, Michael

    2000-01-01

    Discusses the evolution of smart cards from digital signatures and other innovations into the realm of magnetic-stripe cards to expand their applications. Examples of magnetic-strip smart card usage are examined. (GR)

  16. Print a Bed Bug Card

    Science.gov (United States)

    Two sets of business card-sized lists of tips for prevention of bed bug infestations, one for general use around home, the other for travelers. Print a single card or a page of cards for distribution.

  17. NOC rate card catalog

    OpenAIRE

    2014-01-01

    The Salt Lake 2002 rate card is a detailed list of products and services available for rent by National Olympic Committees (NOCs) during the Salt Lake 2002 Olympic Winter Games. The rental process, explained in this document, includes ordering, invoicing, payment, procurement, delivery, installation, commissioning, on-site maintenance and service, collection and removal of rate card products.

  18. Method card design dimensions

    DEFF Research Database (Denmark)

    Wölfel, Christiane; Merritt, T.

    2013-01-01

    There are many examples of cards used to assist or provide structure to the design process, yet there has not been a thorough articulation of the strengths and weaknesses of the various examples. We review eighteen card-based design tools in order to understand how they might benefit designers....... The card-based tools are explained in terms of five design dimensions including the intended purpose and scope of use, duration of use, methodology, customization, and formal/material qualities. Our analysis suggests three design patterns or archetypes for existing card-based design method tools...... and highlights unexplored areas in the design space. The paper concludes with recommendations for the future development of card-based methods for the field of interaction design....

  19. REPLACEMENT OF FRENCH CARDS

    CERN Multimedia

    Human Resources Division

    2001-01-01

    The French Ministry of Foreign Affairs has informed the Organization that it is shortly to replace all diplomatic cards, special cards and employment permits ('attestations de fonctions') now held by members of the personnel and their families. Between 2 July and 31 December 2001, these cards are to be replaced by secure, computerized equivalents. A 'personnel office' stamped photocopy of the old cards may continue to be used until 31 December 2001. For the purposes of the handover, members of the personnel must go personally to the cards office (33/1-015), between 8:30 and 12:30, in order to fill a 'fiche individuelle' form (in black ink only), which has to be personally signed by themselves and another separately signed by members of their family, taking the following documents for themselves and members of their families already in possession of a French card : A recent identity photograph in 4.5 cm x 3.5 cm format (signed on the back) The French card in their possession an A4 photocopy of the same Fre...

  20. Vibration Damping Circuit Card Assembly

    Science.gov (United States)

    Hunt, Ronald Allen (Inventor)

    2016-01-01

    A vibration damping circuit card assembly includes a populated circuit card having a mass M. A closed metal container is coupled to a surface of the populated circuit card at approximately a geometric center of the populated circuit card. Tungsten balls fill approximately 90% of the metal container with a collective mass of the tungsten balls being approximately (0.07) M.

  1. Hydrogen gas detector card

    Directory of Open Access Journals (Sweden)

    Francisco Sánchez Niño

    2016-04-01

    Full Text Available A small card used for detecting hydrogen gas in a crystal growth system by the liquid phase epitaxy technique was designed and built. The small size of the card enables its portability to other laboratories where leakage detection of hydrogen or other flammable gas is required. Card dimensions are approximately 10 cm long and 5 cm wide enabling easy transportation. The design is based on a microcontroller which reads the signal from the hydrogen sensor and internally compares the read value with preset values. Depending on the signal voltage a red, yellow or green LED will light to indicate the levels of concentration of the flammable gas. The card is powered by a 9 V battery.

  2. Credit Card Quiz.

    Science.gov (United States)

    Marks, Jeff

    2000-01-01

    Describes an activity in which students design credit cards and discover for themselves the mathematical realities of buying on credit. Employs multiple-intelligence theory to increase the chance that all students will be reached. (YDS)

  3. Imaging standards for smart cards

    Science.gov (United States)

    Ellson, Richard N.; Ray, Lawrence A.

    1996-01-01

    'Smart cards' are plastic cards the size of credit cards which contain integrated circuits for the storage of digital information. The applications of these cards for image storage has been growing as card data capacities have moved from tens of bytes to thousands of bytes. This has prompted the recommendation of standards by the X3B10 committee of ANSI for inclusion in ISO standards for card image storage of a variety of image data types including digitized signatures and color portrait images. This paper reviews imaging requirements of the smart card industry, challenges of image storage for small memory devices, card image communications, and the present status of standards. The paper concludes with recommendations for the evolution of smart card image standards towards image formats customized to the image content and more optimized for smart card memory constraints.

  4. Dynamic Virtual Credit Card Numbers

    Science.gov (United States)

    Molloy, Ian; Li, Jiangtao; Li, Ninghui

    Theft of stored credit card information is an increasing threat to e-commerce. We propose a dynamic virtual credit card number scheme that reduces the damage caused by stolen credit card numbers. A user can use an existing credit card account to generate multiple virtual credit card numbers that are either usable for a single transaction or are tied with a particular merchant. We call the scheme dynamic because the virtual credit card numbers can be generated without online contact with the credit card issuers. These numbers can be processed without changing any of the infrastructure currently in place; the only changes will be at the end points, namely, the card users and the card issuers. We analyze the security requirements for dynamic virtual credit card numbers, discuss the design space, propose a scheme using HMAC, and prove its security under the assumption the underlying function is a PRF.

  5. Smart tools for Java Card

    OpenAIRE

    Attali, I; Caromel, D.; Courbis, C.; Henrio, L.; H. Nilsson

    2000-01-01

    This article describes a java Card progamming environment which to a large extent is generated from formal specifications of the syntax and semantics of Java card, the JCRE (Java Card Runtime Environment), and the Java Card APIs. The resulting environment consists of a set of tightly integrated and somewhat smart tools, such as a Java specific structure editor and a simulator which allows an application to be tested before being downloaded to a card. Furthermore, the simulator analyses the ap...

  6. 26 CFR 1.475(g)-1 - Effective dates.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 6 2010-04-01 2010-04-01 false Effective dates. 1.475(g)-1 Section 1.475(g)-1...) INCOME TAXES Inventories § 1.475(g)-1 Effective dates. (a)-(b) (c) Section 1.475(a)-3 (concerning... to apply to the security solely because of the effective dates in this paragraph (d) (rather than...

  7. Reduced hepatic tumor incidence in cyclin G1-deficient mice

    DEFF Research Database (Denmark)

    Jensen, Michael Rugaard; Factor, Valentina M; Fantozzi, Anna

    2003-01-01

    Cyclin G1 is a transcriptional target of the tumor suppressor p53, and its expression is increased after DNA damage. Recent data show that cyclin G1 can regulate the levels of p53 by a mechanism that involves dephosphorylation of Mdm2 by protein phosphatase 2A. To understand the biologic role...

  8. Disruption - Access cards service

    CERN Multimedia

    2014-01-01

    We would like to inform you that between 10 November and 15 December 2014, the access cards service in Building 55 will be disrupted, as the GS Department has decided to improve the facilities for users of this building. During the work, you will find the registration, biometric registration and dosimeter exchange services on the second floor of Building 55 and the vehicle sticker service on the ground floor along with the access cards service. We thank you for your understanding and apologise for any inconvenience caused.

  9. Verification of Java Card programs

    OpenAIRE

    Stenzel, Kurt

    2005-01-01

    Smart cards are used in security critical applications where money or private data is involved. Examples are the German Geldkarte or new passports with biometrical data. Design or programming errors can have severe consequences. Formal methods are the best means to avoid errors. Java Card is a restricted version of Java to program smart cards. This work presents a logical calculus to formally prove the correctness and security of Java Card programs. The calculus is implemented in the KIV syst...

  10. Rapid biodegradation of organophosphorus pesticides by Stenotrophomonas sp. G1

    Energy Technology Data Exchange (ETDEWEB)

    Deng, Shuyan; Chen, Yao [Key Laboratory of Agri-food Safety of Anhui Province, Lab of Quality & Safety and Risk Assessment for Agro-products on Storage and Preservation (Hefei), Ministry of Agriculture, School of Resource and Environment, Anhui Agricultural University, Hefei 230036 (China); Wang, Daosheng [School of Life Science, Anhui Agricultural University, Hefei 230036 (China); Shi, Taozhong; Wu, Xiangwei; Ma, Xin; Li, Xiangqiong [Key Laboratory of Agri-food Safety of Anhui Province, Lab of Quality & Safety and Risk Assessment for Agro-products on Storage and Preservation (Hefei), Ministry of Agriculture, School of Resource and Environment, Anhui Agricultural University, Hefei 230036 (China); Hua, Rimao, E-mail: rimaohua@ahau.edu.cn [Key Laboratory of Agri-food Safety of Anhui Province, Lab of Quality & Safety and Risk Assessment for Agro-products on Storage and Preservation (Hefei), Ministry of Agriculture, School of Resource and Environment, Anhui Agricultural University, Hefei 230036 (China); Tang, Xinyun [School of Life Science, Anhui Agricultural University, Hefei 230036 (China); Li, Qing X. [Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, 1955 East–West Road, Honolulu, HI 957822 (United States)

    2015-10-30

    Highlights: • Stenotrophomonas sp. G1 was isolated from chlorpyrifos contaminated sludge. • Strain G1 is closest to Stenotrophomonas acidaminiphila. • Strain G1 can efficiently degrade 8 organophosphorus pesticides (OPs). • Intracellular methyl parathion hydrolase is responsible for the OP degradation. • Three factors were orthogonally optimized for degradation of methyl parathion. - Abstract: Organophosphorus insecticides have been widely used, which are highly poisonous and cause serious concerns over food safety and environmental pollution. A bacterial strain being capable of degrading O,O-dialkyl phosphorothioate and O,O-dialkyl phosphate insecticides, designated as G1, was isolated from sludge collected at the drain outlet of a chlorpyrifos manufacture plant. Physiological and biochemical characteristics and 16S rDNA gene sequence analysis suggested that strain G1 belongs to the genus Stenotrophomonas. At an initial concentration of 50 mg/L, strain G1 degraded 100% of methyl parathion, methyl paraoxon, diazinon, and phoxim, 95% of parathion, 63% of chlorpyrifos, 38% of profenofos, and 34% of triazophos in 24 h. Orthogonal experiments showed that the optimum conditions were an inoculum volume of 20% (v/v), a substrate concentration of 50 mg/L, and an incubation temperature in 40 °C. p-Nitrophenol was detected as the metabolite of methyl parathion, for which intracellular methyl parathion hydrolase was responsible. Strain G1 can efficiently degrade eight organophosphorus pesticides (OPs) and is a very excellent candidate for applications in OP pollution remediation.

  11. Follow Up: Credit Card Caution

    Science.gov (United States)

    Cahill, Timothy P.

    2007-01-01

    In "Pushing Plastic," ("The New England Journal of Higher Education", Summer 2007), John Humphrey notes that many college administrators justify their credit card solicitations by suggesting that credit card access will help students learn to manage their own finances. Instead, credit card debt will teach thousands of students…

  12. Smart Icon Cards

    Science.gov (United States)

    Dunbar, Laura

    2015-01-01

    Icons are frequently used in the music classroom to depict concepts in a developmentally appropriate way for students. SmartBoards provide music educators yet another way to share these manipulatives with students. This article provides a step-by-step tutorial to create Smart Icon Cards using the folk song "Lucy Locket."

  13. The Eggen Card Project

    Science.gov (United States)

    Silvis, G.

    2014-06-01

    (Abstract only) Olin Eggen, noted astronomer (1919-1998), left to us all his raw observation records recorded on 3x5 cards. This project is to make all this data available as an online resource. History and progress of the project will be presented. Project details available at: https://sites.google.com/site/eggencards/home.

  14. Smart card multiple function badge

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, R.A.

    1993-06-01

    Smart cards are credit card-sized computers with integrated data storage, an operating system to manage the data, and built-in security features that protect the data. They are used to distribute information to remote sites, providing the same or greater reliability, data integrity, and information security than a network system. However, smart cards may provide greater functionality at a lower cost than network systems. The US Department of Energy Hanford Site is developing the smart card to be used as a multiple function identification badge that will service various data management requirements on the Site. This paper discusses smart card technology and the proposed Hanford Site applications.

  15. REMINDER REPLACEMENT OF FRENCH CARDS

    CERN Multimedia

    Human Resources Division; Cards.Service@cern.ch

    2001-01-01

    The French Ministry of Foreign Affairs is currently replacing all diplomatic cards, special cards and employment permits («attestations de fonctions») held by members of the personnel and their families. These cards are replaced by secure, computerized equivalents. The old cards may no longer be used after 31 December 2001. For the purposes of the handover, members of the personnel must go personally to the cards office (33/1-015) between 8h30 and 12h30, in order to fill in a «fiche individuelle» form, taking the following documents for themselves and members of their families already in possession of a French card : A recent identity photograph in 4.5 cm x 3.5 cm format, the French card in their possession, an A4 photocopy of the same French card, certified by the cards office as being a true copy. Those members of the personnel whose cards (and/or cards belonging to members of their families) are shortly due to expire, or have recently done so, are also requested...

  16. Tolerance of Deregulated G1/S Transcription Depends on Critical G1/S Regulon Genes to Prevent Catastrophic Genome Instability

    Directory of Open Access Journals (Sweden)

    Catia Caetano

    2014-12-01

    Full Text Available Expression of a G1/S regulon of genes that are required for DNA replication is a ubiquitous mechanism for controlling cell proliferation; moreover, the pathological deregulated expression of E2F-regulated G1/S genes is found in every type of cancer. Cellular tolerance of deregulated G1/S transcription is surprising because this regulon includes many dosage-sensitive proteins. Here, we used the fission yeast Schizosaccharomyces pombe to investigate this issue. We report that deregulating the MBF G1/S regulon by eliminating the Nrm1 corepressor increases replication errors. Homology-directed repair proteins, including MBF-regulated Ctp1CtIP, are essential to prevent catastrophic genome instability. Surprisingly, the normally inconsequential MBF-regulated S-phase cyclin Cig2 also becomes essential in the absence of Nrm1. This requirement was traced to cyclin-dependent kinase inhibition of the MBF-regulated Cdc18Cdc6 replication origin-licensing factor. Collectively, these results establish that, although deregulation of G1/S transcription is well tolerated by cells, nonessential G1/S target genes become crucial for preventing catastrophic genome instability.

  17. Japanese Tarot Cards

    Directory of Open Access Journals (Sweden)

    Laura Miller

    2017-04-01

    Full Text Available This essay looks at selected images from tarot decks designed in Japan. Tarot decks reflect a deliberate adaptation process across both cultural and temporal borders, with visual components created and customized for a Japanese viewer. My aim is to consider the nature of these changes in imagery and to focus attention on an under-analyzed and mostly female-gendered domain. In particular, I look at the way the medieval European people and elements originally found on the cards are replaced with images from the world of Japanese art, history, and popular culture. These substitutions either gloss over the gaps between Western and Japanese world views or meld them into a new form, allowing the tarot entry into a different or hybrid metaphysical culture. Attention to tarot cards is important because of their great economic and cultural impact in contemporary Japan. A widespread love of tarot in Japan provides insight into domains of pleasure, spiritual exploration, and fandom.

  18. Proxy Smart Card Systems

    OpenAIRE

    Cattaneo, Giuseppe; Faruolo, Pompeo; Palazzo, Vincenzo; Visconti, Ivan

    2010-01-01

    International audience; The established legal value of digital signatures and the growing availability of identity-based digital services are progressively extending the use of smart cards to all citizens, opening new challenging scenarios. Among them, motivated by concrete applications, secure and practical delegation of digital signatures is becoming more and more critical. Unfortunately, secure delegation systems proposed so far (e.g., proxy signatures) include various drawbacks for any pr...

  19. M/G/1 with Exceptional Service and Arrival Rate

    Science.gov (United States)

    1988-10-31

    The model M/G/1 is modified by 1) providing the pioneer customer, i. e. the customer who terminates an idle period (an initiates a busy period) with...distinguish between the perception of the observer and of the customer source. Keywords: Stochastic models.

  20. 26 CFR 1.167(g)-1 - Basis for depreciation.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Basis for depreciation. 1.167(g)-1 Section 1.167... for depreciation. The basis upon which the allowance for depreciation is to be computed with respect... property at that time, is the basis for computing depreciation. ...

  1. A Mechanism for Anonymous Credit Card Systems

    Science.gov (United States)

    Tamura, Shinsuke; Yanase, Tatsuro

    This paper proposes a mechanism for anonymous credit card systems, in which each credit card holder can conceal individual transactions from the credit card company, while enabling the credit card company to calculate the total expenditures of transactions of individual card holders during specified periods, and to identify card holders who executed dishonest transactions. Based on three existing mechanisms, i.e. anonymous authentication, blind signature and secure statistical data gathering, together with implicit transaction links proposed here, the proposed mechanism enables development of anonymous credit card systems without assuming any absolutely trustworthy entity like tamper resistant devices or organizations faithful both to the credit card company and card holders.

  2. Identification of waiting time distribution of M/G/1, Mx/G/1, GIr/M/1 queueing systems

    Directory of Open Access Journals (Sweden)

    A. Ghosal

    1988-01-01

    Full Text Available This paper brings out relations among the moments of various orders of the waiting time of the 1st customer and a randomly selected customer of an arrival group for bulk arrivals queueing models, and as well as moments of the waiting time (in queue for M/G/1 queueing system. A numerical study of these relations has been developed in order to find the (β1,β2 measures of waiting time distribution in a comutable form. On the basis of these measures one can look into the nature of waiting time distribution of bulk arrival queues and the single server M/G/1 queue.

  3. Probabilities in the Card Game of Three Cards

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 9; Issue 3. Probabilities in the Card Game of Three Cards. A W Joshi M W Joshi. Classroom Volume 9 Issue 3 March 2004 pp 76-77. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/009/03/0076-0077 ...

  4. Print a Bed Bug Card - (Page of Cards)

    Science.gov (United States)

    For mass distribution: two sets of business-card-sized lists of tips for recognizing bed bugs and signs of an infestation, including a photo of bed bugs to assist identification. One card is for general use around home or office, the other for travelers.

  5. British and American attitudes toward credit cards.

    Science.gov (United States)

    Yang, Bijou; James, Simon; Lester, David

    2006-04-01

    American university students owned more than twice as many credit cards as British university students. However, scores on a credit card attitude scale predicted the number of cards owned by respondents in both countries.

  6. It's All in the Cards.

    Science.gov (United States)

    Burke, Jim

    2002-01-01

    Describes how the author learned by watching low-achieving students play intricate card games such as "Magic" that they can learn, can remember, and certainly can master information. Realizes that these cards were advanced learning tools, multifaceted texts using color, symbols, images, texts, and metaphor to help create a world of…

  7. Electronic payments using payment cards

    NARCIS (Netherlands)

    Waaij, B.D. van der; Siljee, B.I.J.; Broekhuijsen, B.J.; Ponsioen, C.; Maas, A.; Aten, R.M.; Hoepman, J.H.; Loon, J.H. van; Smit, M.

    2009-01-01

    A method of making a payment uses a mobile communication device (1) and a payment card (2), both the mobile communication device (1) and the payment card (2) being provided with a respective near field communication unit (11, 21) and at least the mobile communication device (1) being provided with

  8. Smart Cards and remote entrusting

    Science.gov (United States)

    Aussel, Jean-Daniel; D'Annoville, Jerome; Castillo, Laurent; Durand, Stephane; Fabre, Thierry; Lu, Karen; Ali, Asad

    Smart cards are widely used to provide security in end-to-end communication involving servers and a variety of terminals, including mobile handsets or payment terminals. Sometime, end-to-end server to smart card security is not applicable, and smart cards must communicate directly with an application executing on a terminal, like a personal computer, without communicating with a server. In this case, the smart card must somehow trust the terminal application before performing some secure operation it was designed for. This paper presents a novel method to remotely trust a terminal application from the smart card. For terminals such as personal computers, this method is based on an advanced secure device connected through the USB and consisting of a smart card bundled with flash memory. This device, or USB dongle, can be used in the context of remote untrusting to secure portable applications conveyed in the dongle flash memory. White-box cryptography is used to set the secure channel and a mechanism based on thumbprint is described to provide external authentication when session keys need to be renewed. Although not as secure as end-to-end server to smart card security, remote entrusting with smart cards is easy to deploy for mass-market applications and can provide a reasonable level of security.

  9. PREL Pacific Region Language Cards.

    Science.gov (United States)

    Pacific Region Educational Lab., Honolulu, HI.

    This collection of 10 cue cards presents English translations of common English words and expressions into 10 Pacific Region languages: Palauan, Samoan, Chamorro, Hawaiian, Carolinian, Chuukese, Pohnpeian, Marshallese, Yapese, and Kosraean. The cards translate the following: hello, good morning, good afternoon, good night, thank you, you're…

  10. Current directions in smart cards

    NARCIS (Netherlands)

    Domingo-Ferrer, Josep; Hartel, Pieter H.

    Smart cards are portable computing devices which are leaving their past role as mere key repositories to become full-fledged computers. This transition has been made possible by recent developments in smart card technology, regarding both hardware and software. This special issue covers some of

  11. Punch card programmable microfluidics.

    Directory of Open Access Journals (Sweden)

    George Korir

    Full Text Available Small volume fluid handling in single and multiphase microfluidics provides a promising strategy for efficient bio-chemical assays, low-cost point-of-care diagnostics and new approaches to scientific discoveries. However multiple barriers exist towards low-cost field deployment of programmable microfluidics. Incorporating multiple pumps, mixers and discrete valve based control of nanoliter fluids and droplets in an integrated, programmable manner without additional required external components has remained elusive. Combining the idea of punch card programming with arbitrary fluid control, here we describe a self-contained, hand-crank powered, multiplex and robust programmable microfluidic platform. A paper tape encodes information as a series of punched holes. A mechanical reader/actuator reads these paper tapes and correspondingly executes operations onto a microfluidic chip coupled to the platform in a plug-and-play fashion. Enabled by the complexity of codes that can be represented by a series of holes in punched paper tapes, we demonstrate independent control of 15 on-chip pumps with enhanced mixing, normally-closed valves and a novel on-demand impact-based droplet generator. We demonstrate robustness of operation by encoding a string of characters representing the word "PUNCHCARD MICROFLUIDICS" using the droplet generator. Multiplexing is demonstrated by implementing an example colorimetric water quality assays for pH, ammonia, nitrite and nitrate content in different water samples. With its portable and robust design, low cost and ease-of-use, we envision punch card programmable microfluidics will bring complex control of microfluidic chips into field-based applications in low-resource settings and in the hands of children around the world.

  12. Digitizing Olin Eggen's Card Database

    Science.gov (United States)

    Crast, J.; Silvis, G.

    2017-06-01

    The goal of the Eggen Card Database Project is to recover as many of the photometric observations from Olin Eggen's Card Database as possible and preserve these observations, in digital forms that are accessible by anyone. Any observations of interest to the AAVSO will be added to the AAVSO International Database (AID). Given to the AAVSO on long-term loan by the Cerro Tololo Inter-American Observatory, the database is a collection of over 78,000 index cards holding all Eggen's observations made between 1960 and 1990. The cards were electronically scanned and the resulting 108,000 card images have been published as a series of 2,216 PDF files, which are available from the AAVSO web site. The same images are also stored in an AAVSO online database where they are indexed by star name and card content. These images can be viewed using the eggen card portal online tool. Eggen made observations using filter bands from five different photometric systems. He documented these observations using 15 different data recording formats. Each format represents a combination of filter magnitudes and color indexes. These observations are being transcribed onto spreadsheets, from which observations of value to the AAVSO are added to the AID. A total of 506 U, B, V, R, and I observations were added to the AID for the variable stars S Car and l Car. We would like the reader to search through the card database using the eggen card portal for stars of particular interest. If such stars are found and retrieval of the observations is desired, e-mail the authors, and we will be happy to help retrieve those data for the reader.

  13. Caquexia cardíaca

    OpenAIRE

    A. Miján de la Torre; E. Martín de la Torre; de Mateo Silleras, Beatriz

    2006-01-01

    La insuficiencia cardíaca de carácter crónico (ICC), en especial si afecta al corazón derecho, ocasiona con frecuencia malnutrición. Si esta es grave y se unen otros componentes, puede producirse caquexia cardíaca. Esta se asocia a mayor morbilidad y menor supervivencia de los pacientes que la padecen. Las causas de la caquexia cardíaca son diversas, en general asociadas a mantener balance energético negativo, surgiendo cada vez mayor evidencia que apoya un origen multifactorial de la m...

  14. The c-cards game

    DEFF Research Database (Denmark)

    Valente, Andrea

    2005-01-01

    C-cards are an easy-to-reify, graphical formalism capable of expressing computational systems, discrete both in time and in space. The main goal of the project aims at scaling-down the learning complexity of Computer Science core contents. We argue that our cards present many dimensions of flexib...... of flexibility, resulting in a highly customizable learning object, that gives teachers and pedagogues freedom with respect to reification and deployment strategies. The correlation between the c-cards game and children's soft skills is also discussed....

  15. From EuCARD to EuCARD-2

    CERN Multimedia

    Chaudron, M

    2013-01-01

    The one word that best describes the spirit of the EuCARD ’13 event (see here) that took place from 10 to 14 June at CERN is "collaboration". The event brought together more than 180 accelerator specialists from all over the world to celebrate the conclusion of the EuCARD project and to kick off its successor, EuCARD-2.   EuCARD-2 brings a global view to particle accelerator research in order to address challenges for future generations of accelerators. The project officially began on 1 May 2013 and will run for four years. With a total budget of €23.4 million, including an €8 million EU contribution, it will build upon the success of EuCARD and push it into an even more innovative regime. EuCARD-2 aims to significantly enhance multidisciplinary R&D for European accelerators and will actively contribute to the development of a European Research Area in accelerator science. This will be accomplished by promoting complementary expertise, cross-d...

  16. Credit Cards. Bulletin No. 721. (Revised.)

    Science.gov (United States)

    Fox, Linda Kirk

    This cooperative extension bulletin provides basic information about credit cards and their use. It covers the following topics: types of credit cards (revolving credit, travel and entertainment, and debit); factors to consider when evaluating a credit card (interest rates, grace period, and annual membership fee); other credit card costs (late…

  17. [Microprocessor cards and portable medical record].

    Science.gov (United States)

    Beuscart, R; Ghosn, N; Haye, M P

    1996-02-01

    The smart cards are considered as "intermittently connected devices" ensuring the security and the confidentiality of the data. This technique can be used in the healthcare domain for 2 types of applications: 1. patient cards for administrative functions (Social Security card, identification card) or medical purposes (general medical record or "niche" cards); 2. healthcare professionals cards for identification, authentification of the bearers. Electronic signature and cryptography algorithms reinforce the security of the transactions in medical informatics and telematics. In every case, the smart card must be considered as a mobile tool, intermittently connected with a larger, not limited information system.

  18. Bankruptcy Reform and Credit Cards

    National Research Council Canada - National Science Library

    Michelle J. White

    2007-01-01

    .... Personal bankruptcy filings fell to 600,000 in 2006. This paper explores why personal bankruptcy rates rose, and will argue that the main reason is the growth of "revolving debt"--mainly credit card debt...

  19. RENEWAL OF SWISS LEGITIMATION CARDS

    CERN Multimedia

    Division des Ressources Humaines; Human Resources Division; Tel. 79494-74683

    2000-01-01

    Members of the personnel, holders of SWISS LEGITIMATION CARDS due to expire during the year 2000, need to change them. Those concerned should bring : - a recent passport photo (with NAME and first name on the back) - the expired (or due to expire) card and a recto-verso photocopy on A4 size paper (for certified authentication) to: Bureau des cartes, bât 33.1-009/1-011. HR Division will notify members of personnel as soon as the new cards are available. Be careful: if you are in possession of expired cards (Swiss or French), or if you present non-certified copies, the Organization will not take any responsibility in case of difficulties with the customs authorities or the police.

  20. RENEWAL OF SWISS LEGITIMATION CARDS

    CERN Multimedia

    Human Resources Division; Human Resources Division; Tel. 79494-74683

    2000-01-01

    Members of the personnel, holders of SWISS LEGITIMATION CARDS due to expire during the year 2000, need to change them. Those concerned should bring: ­ a recent passport photo (with NAME and first name on the back) ­ the expired (or due to expire) card and a recto-verso photocopy on A4 size paper (for certified authentication) to: Bureau des cartes, Bât 33.1-009/1-011 Members of the personnel will be notified by HR Division as soon as the new cards are available. Be careful: if you are in possession of expired cards (Swiss or French), or if you present non-certified copies, the Organization will not take any responsability in case of difficulties with the customs authorities or the police.

  1. RENEWAL OF SWISS LEGITIMATION CARDS

    CERN Multimedia

    Division des Ressources Humaines; Human Resources Division; Tel. 79494-74683

    2000-01-01

    Members of the personnel, holders of SWISS LEGITIMATION CARDS due to expire during the year 2000, need to change them. Those concerned should bring: - a recent passport photo (with NAME and first name on the back) - the expired (or due to expire) card and a recto-verso photocopy on A4 size paper (for certified authentication) to: Bureau des cartes, bldg 33.1-009/1-011. HR Division will notify members of personnel as soon as the new cards are available.Be careful: if you are in possession of expired cards (Swiss or French), or if you present non-certified copies, the Organisation will not take any responsibility in case of difficulties with the customs authorities or the police.

  2. RENEWAL OF SWISS LEGITIMATION CARDS

    CERN Multimedia

    HR Division

    2001-01-01

    Members of the personnel and their families, holders of SWISS LEGITIMATION CARDS due to expire during the year 2001, need to change them. Those concerned should bring : a recent passport photo (with NAME and first name on the back) the expired (or due to expire) card and a recto-verso photocopy on A4 size paper (for certified authentication) to Bureau des cartes, building 33/1-009/1-015. Members of the personnel will be notified by the Social and Statutary Conditions Group, HR Division as soon as the new cards are available. Be careful: If you are in possession of expired cards (Swiss or French), or if you present non-certified copies, the Organization will not take any responsibility in case of difficulties with the customs authorities or the police.

  3. RENEWAL OF SWISS LEGITIMATION CARDS

    CERN Multimedia

    Division des Ressources Humaines; Human Resources Division; Tel. 79494-74683

    2000-01-01

    Members of the personnel, holders of SWISS LEGITIMATION CARDS due to expire during the year 2000, need to change them. Those concerned should bring : a recent passport photo (with NAME and first name on the back) the expired (or due to expire) card and a recto-verso photocopy on A4 size paper (for certified authentication)to: Bureau des cartes, Bât 33.1-009/1-011. Members of personnel will be notified by HR Division as soon as the new cards are available. Be careful: if you are in possession of expired cards (Swiss or French), or if you present non-certified copies, the Organization will not take any responsibility in case of difficulties with the customs authorities or the police.

  4. Notification: Management of Travel Cards

    Science.gov (United States)

    Project #OA-FY15-0156, April 20, 2015. The U.S. Environmental Protection Agency (EPA), Office of Inspector General (OIG), plans to begin preliminary research for an audit of the management of travel cards.

  5. OPENING HOURS FOR CARDS OFFICE

    CERN Multimedia

    Human Resources Division

    2001-01-01

    Due to the extra workload generated by the global renewal of French cards and in order to preserve the level of service offered by the cards office, please note that this office will in future be open every morning from 8.30 a.m. to 12.30 p.m. until further notice. The service can be contacted by telephone during the same hours. Thank you for your understanding.

  6. Dosimetric intercomparison in Cobalt 60 unities using TLD-100 crystals and CaSO{sub 4}: Dy + Ptfe; Intercomparacion dosimetrica en unidades de cobalto 60 usando cristales de TLD-100 y CaSO{sub 4}: Dy + PTFE

    Energy Technology Data Exchange (ETDEWEB)

    Gaona, E. [Universidad Autonoma Metropolitana Xochimilco, Mexico D.F. (Mexico); Azorin N, J. [Universidad Autonoma Metropolitana Iztapalapa, Mexico D.F. (Mexico); Perez P, M.A. [Instituto Nacional de Cancerologia, Mexico D.F. (Mexico); Castillo H, M. [Centro Medico Nacional 20 de Noviembre, ISSSTE, Mexico D.F. (Mexico); Flores F, F. [Unidad de Oncologia, Centro Medico Nacional, IMSS, Mexico D.F. (Mexico); Guzman R, L.V. [Unidad de Oncologia, Hospital General de Mexico, Mexico D.F. (Mexico)

    1999-07-01

    The purpose of this work is to design and construct a phantom in basis of thermoplastic polymer of methyl methacrylate that is reutilizable and which allows to do an analysis of the absorbed doses in thermoluminescent crystals (Tl) exposed to cobalt 60 to establish the dosimetric intercomparison in cobalt units which allows to do the follow-up of the Quality assurance programs, standardization of calibration procedures, dosimetry and TLD post intercomparison in radiotherapy. This work allows also prove new thermoluminescent materials of national manufacture developed by Juan Azorin and collaborators as the CaSO{sub 4}: Dy + Ptfe. This is a first study which is realized in Mexico with the system crystal-phantom for aims to intercomparison in cobalt 60 units. In this work participate eight unities of cobalt 60 of different trades belonging at four radiotherapy centers. The results of the dose intercomparison of the eight unities of cobalt 60 were in the range 0.95-1.13, taking in account that the values between 0.95 and 1.05 were considered acceptable in terms of the requirements by the standing legislation. (Author)

  7. Credit Card Debt Hardship Letter Samples

    OpenAIRE

    lissa coffey

    2016-01-01

    Having trouble with your credit card debt? Below you will find examples of hardship letters. There are several things to consider when writing a credit card hardship letter. A hardship letter is the first step to letting the credit card company know that things are bad. This free credit card hardship letter sample is only a guide in order to start the negotiation. Credit card debt hardship letter example, hardship letter to credit card. If you are having trouble paying off your debt and need ...

  8. Swiss and French cards - Reminder

    CERN Multimedia

    HR Department

    2011-01-01

    Communication from the HR Department to members of personnel holding an employment or association contract, above 50% and for more than 3 months, with the Organization. The HR Department would like to remind all members of the personnel concerned that they are obliged to: hold a valid Swiss Légitimation card AND a valid French card (“Titre de séjour spécial” or “attestation de fonctions”) at all times during the exercise of their functions in the Organization; return these documents as soon as their functions in the Organization cease. Not following these rules could be prejudicial to the Organization and appropriate measures may be taken with respect to the member of the personnel concerned. Information and procedures concerning Swiss and French cards (first application, renewal, theft/loss, etc.) are available in the Admin e-guide: https://cern.ch/admin-eguide/cartes/proc_cartes_home.asp Users and Unpaid Associates must ...

  9. Reminder: Swiss and French cards

    CERN Multimedia

    2012-01-01

    Communication from the HR Department to members of personnel holding an employment or association contract, above 50% and for more than 3 months, with the Organization. The HR Department would like to remind all members of personnel concerned that they are obliged to: • hold a valid Swiss  Légitimation card AND a valid French card (“Titre de séjour spécial” or “attestation de fonctions”) at all times during the exercise of their functions in the Organization; • return these documents as soon as their functions in the Organization cease. Not following these rules could be prejudicial to the Organization and appropriate measures may be taken towards the member of personnel concerned. Information and procedures concerning Swiss and French cards (first application, renewal, theft/loss, etc.) are available in the Admin e-guide. Users and Unpaid Associates must contact the Users Office HR Department Tel.: 729...

  10. RENEWAL OF SWISS LEGITIMATION CARDS

    CERN Multimedia

    HR DIVISION

    2000-01-01

    Members of the personnel, holders of SWISS LEGITIMATION CARDSdue to expire during the year 2000, need to change them.Those concerned should bring:a recent passport photo (with NAME and first name on the back)the expired (or due to expire) card and a photocopy (for certified authentication)to: Bureau des cartes, building 33/1-025Members of personnel will be notified by HR Division as soon as the new cards are available.Be careful: if you are in possession of expired cards (Swiss or French), or if you present non-certified copies, the Organization will not take any responsibility in case of difficulties with the customs authorities or the police.Human Resources DivisionTel. 79494-74683

  11. RENEWAL OF SWISS LEGITIMATION CARDS

    CERN Multimedia

    HR Division

    2000-01-01

    Members of the personnel, holders ofSWISS LEGITIMATION CARDSdue to expire during the year 2000, need to change them.Those concerned should bring:a recent passport photo (with NAME and first name on the back)the expired (or due to expire) card and a recto-verso photocopy on A4 size paper (for certified authentication) to:Bureau des cartes, Bât 33.1-009/1-011.HR Division will notify members of personnel as soon as the new cards are available.Be careful: if you are in possession of expired cards (Swiss or French), or if you present non-certified copies, the Organisation will not take any responsibility in case of difficulties with the customs authorities or the police.Human Resources DivisionTel. 79494-74683

  12. RENEWAL OF SWISS LEGITIMATION CARDS

    CERN Multimedia

    Division des Ressources Humaines

    2000-01-01

    Members of the personnel, holders of SWISS LEGITIMATION CARDSdue to expire during the year 2000, need to change them.Those concerned should bring:-\ta recent passport photo (with NAME and first name on the back)-\tthe expired (or due to expire) card and a recto-verso photocopy on A4 size paper (for certified authentication) to:Bureau des cartes, bât 33.1-009/1-011.HR Division will notify members of personnel as soon as the new cards are available.Be careful: if you are in possession of expired cards (Swiss or French), or if you present non-certified copies, the Organisation will not take any responsibility in case of difficulties with the customs authorities or the police.Human Resources DivisionTel. 79494-74683

  13. Calibration of TOB+ Thermometer's Cards

    CERN Document Server

    Banitt, Daniel

    2014-01-01

    Motivation - Under the new upgrade of the CMS detector the working temperature of the trackers had been reduced to -27 Celsius degrees. Though the thermal sensors themselves (Murata and Fenwal thermistors) are effective at these temperatures, the max1542 PLC (programmable logic controller) cards, interpreting the resistance of the thermal sensors into DC counts usable by the DCS (detector control system), are not designed for these temperatures in which the counts exceed their saturation and therefor had to be replaced. In my project I was in charge of handling the emplacement and calibration of the new PLC cards to the TOB (tracker outer barrel) control system.

  14. An Anonymous Credit Card System

    Science.gov (United States)

    Androulaki, Elli; Bellovin, Steven

    Credit cards have many important benefits; however, these same benefits often carry with them many privacy concerns. In particular, the need for users to be able to monitor their own transactions, as well as bank’s need to justify its payment requests from cardholders, entitle the latter to maintain a detailed log of all transactions its credit card customers were involved in. A bank can thus build a profile of each cardholder even without the latter’s consent. In this paper, we present a practical and accountable anonymous credit system based on ecash, with a privacy preserving mechanism for error correction and expense-reporting.

  15. Defense Mechanism Card Pull in TAT Stories.

    Science.gov (United States)

    Cramer, Phebe

    2017-01-01

    This study investigates the question of whether different Thematic Apperception Test (TAT; Murray, 1943 ) cards are likely to prompt stories that are characterized by different defense mechanisms. This condition is known as card pull and refers to the probability that different TAT cards elicit different personality scores for the same variable. If so, the assessment of defense use would be importantly influenced by the TAT cards used in an assessment. TAT stories from 3 different community samples were examined (Ns = 91, 98, 121), using a statistical method developed by Stein et al ( 2014 ). The results indicated that different TAT cards pull for different defenses, as assessed by the Defense Mechanism Manual (DMM: Cramer, 1991b ). However, the nature of card pull was not always consistent across samples. These dissimilarities could be due to group differences, or to the presence of different TAT cards used in the test battery, indicating that card pull is importantly determined by context.

  16. NCDC Punched Card Inventory - 1950s

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Index of foreign weather data available on punched cards held at the Joint Punched Card Library in Asheville NC, produced in the late 1950s, and also station/data...

  17. Smart Card Driving License System in Gujarat

    OpenAIRE

    Deepak Kumar

    2005-01-01

    Gujarat was the first state in India which introduced the smart card license system in 1999. It was the first place in the world which introduced this innovative system and, thus, its implementation was a real challenge. As of now, Gujarat Government has issued 5 million smart card driving licenses to its people. This card is basically a plastic card having ISO 7810 certification and integrated circuit,capable of storing and verifying information according to its programming. To avoid corrupt...

  18. Main components of business cards design

    Directory of Open Access Journals (Sweden)

    Ю. В. Романенкова

    2003-03-01

    Full Text Available The essay is dedicated to the urgent problem of necessity of creation of professional design of business cards, that are important part of the image of modem businessman. There are classification of cards by functional principle, the functions of cards of each type were analyzed. All components of business card, variants of its composition schemes, color characteristics, principles of use of trade marks and other design elements have been allocated

  19. Credit Card Usage and Knowledge in Thailand

    OpenAIRE

    Sangsutisearee, Wanna

    1993-01-01

    This study was conducted to determine the relationship between the characteristics of credit card holders and the extent of credit card usage, the level of credit card knowledge, and the consumer's choice perspectives. The characteristics of credit card holders studied were (a) gender, (b) age, (c) marital status, (d) education, (e) income, and (f) occupation. Data for this study were collected in Bangkok, Thailand by telephone interviews during July- August 1993. The sample consisted of 1...

  20. 26 CFR 301.6311-2 - Payment by credit card and debit card.

    Science.gov (United States)

    2010-04-01

    ..., numerical transposition, or similar mistake; (B) An amount posted to the wrong taxpayer's account; (C) A... disclosure of information relating to payment of taxes by credit card and debit card. Any information or data... by a credit card or debit card shall be treated as confidential, whether such information is received...

  1. Overcoming credit card fraud in South Africa

    African Journals Online (AJOL)

    chip-and-pin technology has so far proved successful in countries such as the United. Kingdom, where total counterfeit card fraud decreased by 32% in the past two years.51 In South. Africa not all cards will have the chip-and-pin feature because not all merchants have the systems installed to support chip-and-pin cards.

  2. 75 FR 55392 - Employment Network Report Card

    Science.gov (United States)

    2010-09-10

    ... ADMINISTRATION Employment Network Report Card AGENCY: Social Security Administration (SSA). ACTION: Notice of... Report Card. SUMMARY: We are soliciting the views of the public, beneficiaries, advocates, Employment... program. We plan to accomplish this goal by combining a user-friendly EN Report Card, which contains...

  3. The HyperCard Launching Pad.

    Science.gov (United States)

    Aufdenspring, Gary; Aufdenspring, Deborah

    1992-01-01

    Describes how HyperCard software can be used to direct students to databases, applications, and explanations in an online environment. The use of HyperCard with other software is discussed; using HyperCard to set up tutorials is explained; and limitations are addressed, including the amount of memory needed and the speed of the hardware. (LRW)

  4. 19 CFR 101.8 - Identification cards.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Identification cards. 101.8 Section 101.8 Customs... GENERAL PROVISIONS § 101.8 Identification cards. Each Customs employee shall be issued an appropriate identification card with that employee's photograph and signature, signed by the appropriate issuing officer. ...

  5. 25 CFR 249.3 - Identification cards.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Identification cards. 249.3 Section 249.3 Indians BUREAU... General Provisions § 249.3 Identification cards. (a) The Commissioner of Indian Affairs shall arrange for the issuance of an appropriate identification card to any Indian entitled thereto as prima facie...

  6. Coding the Eggen Cards (Poster abstract)

    Science.gov (United States)

    Silvis, G.

    2014-06-01

    (Abstract only) A look at the Eggen Portal for accessing the Eggen cards. And a call for volunteers to help code the cards: 100,000 cards must be looked at and their star references identified and coded into the database for this to be a valuable resource.

  7. Virtual Credit Card Processing System

    OpenAIRE

    Gray, Geraldine; Church, Karen; Ayres, Tony

    2015-01-01

    The virtual credit card processing system is an e-business system we have developed which provides a secure and universal mechanism for making purchases over the Internet. The system uses Remote Method Invocation (RMI), Java Server Pages (JSP), Java Servlets and Java Database Connectivity (JDBC). We also look at the possibility of implementing the system using the Web Services architecture.

  8. Towards an open sound card

    DEFF Research Database (Denmark)

    Dimitrov, Smilen; Serafin, Stefania

    2011-01-01

    The architecture of a sound card can, in simple terms, be described as an electronic board containing a digital bus interface hardware, and analog-to-digital (A/D) and digital-to-analog (D/A) converters; then, a soundcard driver software on a personal computer's (PC) operating system (OS) can con...

  9. Improving Institutional Report Card Indicators

    Science.gov (United States)

    McGowan, Veronica

    2016-01-01

    Institutional report cards are increasingly being used by higher educational institutions to present academic outcomes to external audiences of prospective students and parents, as well as program and institutional evaluators. While some prospective students are served by national transparency measures most users mine information from the…

  10. Reminder card helps patients remember OCs.

    Science.gov (United States)

    1999-11-01

    Organon has developed the Reminder Card to help women patients remember their regular intake of oral contraceptive (OC) pills. About 50% of women take birth control pills as prescribed, 25% miss a pill per month, and 25% miss two or more pills in the same time frame. The plastic card, about the size and shape of a credit card, contains a microchip timer. Reminder cards are available to providers who use the Starter Kits issued by the company for new-start patients on the Mircette OC. When patients begin their first pack of pills, they select the time of day they prefer to have the Reminder Card emit its tiny beep. The time is set into the microchip timer and the card is programmed to sound automatically at the pre-set time each day for the next three months. The direction for using the Reminder Card is outlined.

  11. Signal processing for smart cards

    Science.gov (United States)

    Quisquater, Jean-Jacques; Samyde, David

    2003-06-01

    In 1998, Paul Kocher showed that when a smart card computes cryptographic algorithms, for signatures or encryption, its consumption or its radiations leak information. The keys or the secrets hidden in the card can then be recovered using a differential measurement based on the intercorrelation function. A lot of silicon manufacturers use desynchronization countermeasures to defeat power analysis. In this article we detail a new resynchronization technic. This method can be used to facilitate the use of a neural network to do the code recognition. It becomes possible to reverse engineer a software code automatically. Using data and clock separation methods, we show how to optimize the synchronization using signal processing. Then we compare these methods with watermarking methods for 1D and 2D signal. The very last watermarking detection improvements can be applied to signal processing for smart cards with very few modifications. Bayesian processing is one of the best ways to do Differential Power Analysis, and it is possible to extract a PIN code from a smart card in very few samples. So this article shows the need to continue to set up effective countermeasures for cryptographic processors. Although the idea to use advanced signal processing operators has been commonly known for a long time, no publication explains that results can be obtained. The main idea of differential measurement is to use the cross-correlation of two random variables and to repeat consumption measurements on the processor to be analyzed. We use two processors clocked at the same external frequency and computing the same data. The applications of our design are numerous. Two measurements provide the inputs of a central operator. With the most accurate operator we can improve the signal noise ratio, re-synchronize the acquisition clock with the internal one, or remove jitter. The analysis based on consumption or electromagnetic measurements can be improved using our structure. At first sight

  12. Valutazione economica dello studio CARDS

    Directory of Open Access Journals (Sweden)

    Simona de Portu

    2007-10-01

    Full Text Available Introduction: cardiovascular diseases (CVD are the major component of premature mortality, generate disability and are a relevant source of cost. The growing incidence of CVD is associated with lifestyle and other modifiable risk factors. Prevention and preclinical detection of CVD reduce morbidity and mortality. Type 2 diabetes is associated with a substantially increased risk of cardiovascular disease. Objective: the aim of the study was to evaluate the health economic consequence of medical therapy with atorvastatin for primary prevention of major cardiovascular events in patients with type 2 diabetes in Italy. Materials and method: in order to reach our objective we drew clinical information from the CARDS study. This economic evaluation was carried out conducting a cost/effectiveness analysis from the perspective of National Health Service (NHS. The analysis was applied to a time horizon in conformity with the observational period adopted in the CARDS study (3.9 years. An incremental cost/effectiveness ratio (ICER was calculated and is expressed as cost per life years gained (LYG. In order to test the robustness of the results, a one-way sensitivity analysis was performed. Results: the total cost of atorvastatin therapy over 3.9 years amounts to around 1.5 million of euros per 1,000 patients. The total cost of adding atorvastatin to standard care in people treated for primary prevention of major cardiovascular events in type 2 diabetes as those involved in the CARDS study would entail an additional cost of about 1,2 million of euros per 1,000 patients treated per 3.9 years, with an incremental cost/effectiveness ratio (ICER equivalent to 36,566 euros per patient per LYG. Discussion: the current study is the first economic evaluation of CARDS study to the Italian situation. The results of the current study show that hypolipemic therapy with atorvastatin 10 mg in diabetic individuals is to be considered cost effective.

  13. 16 CFR Appendix G1 to Part 305 - Furnaces-Gas

    Science.gov (United States)

    2010-01-01

    ... DISCLOSURES REGARDING ENERGY CONSUMPTION AND WATER USE OF CERTAIN HOME APPLIANCES AND OTHER PRODUCTS REQUIRED UNDER THE ENERGY POLICY AND CONSERVATION ACT (âAPPLIANCE LABELING RULEâ) Pt. 305, App. G1 Appendix G1 to...

  14. Feocromocitoma cardíaco

    Directory of Open Access Journals (Sweden)

    Gustavo L. Knop

    2006-01-01

    Full Text Available Los feocromocitomas cardíacos primarios (FCP son sumamente infrecuentes. Hasta el presente son menos de 50 los casos comunicados en el mundo. Presentamos el caso de un tumor intrapericárdico, que resultó ser un feocromocitoma primario, en una mujer de mediana edad, cuyo signo principal fue hipertensión arterial severa (HTAs. Los estudios diagnósticos por imágenes corroboraron la presencia de un tumor intrapericárdico como único hallazgo y los estudios bioquímicos de catecolaminas y sus metabolitos excretados por orina reafirmaron el diagnóstico etiológico. El tumor fue resecado quirúrgicamente sin complicaciones mediante cirugía cardíaca convencional con circulación extracorpórea (CEC y paro cardíaco con cardioplejía. Siete meses después de la operación, la paciente se encuentra asintomática y normotensa.

  15. Promoter polymorphism MMP-1 (-1607 2G/1G) and MMP-3 (-1612 ...

    Indian Academy of Sciences (India)

    1607 2G1G, -16071G/2G-1G/1G genotypes and -1607 1G allele were associatedwith the development of HAND (OR = 1.64, P = 0.05; OR = 1.45, P = 0.04; OR = 1.69, P = 0.05). MMP-1-16071G1G, MMP-3-16125A5A genotypes increased the risk ...

  16. WHAT INFLUENCE CREDIT CARD DEBTS IN YOUNG CONSUMERS IN MALAYSIA

    OpenAIRE

    Syed Shah ALAM; Ruzita Abdul RAHIM; Ridhwanul HAQ; Atiqur Rahman KHAN

    2014-01-01

    This paper examines empirically antecedents of the credit card debts in young consumers in Malaysia. We examine whether easy access to credit card, credit card related knowledge, aggressive promotion by credit card industry, low minimum payment requirement and attitude towards credit cards influence credit card debts in the younger generation. Regression model was used to meet the objectives. These findings based on a sample of 240 young credit card holders, show that the factors that affect ...

  17. Market structure and credit card pricing: what drives the interchange?

    OpenAIRE

    Zhu Wang

    2008-01-01

    This paper presents a model for the credit card industry, where oligopolistic card networks price their products in a complex marketplace with competing payment instruments, rational consumers/merchants, and competitive card issuers/acquirers. The analysis suggests that card networks demand higher interchange fees to maximize card issuers' profits as card payments become more efficient. At equilibrium, consumer rewards and card transaction volume also increase, while consumer surplus and merc...

  18. 26 CFR 1.904(g)-1 - Overall domestic loss and the overall domestic loss account.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Overall domestic loss and the overall domestic loss account. 1.904(g)-1 Section 1.904(g)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF... States § 1.904(g)-1 Overall domestic loss and the overall domestic loss account. For further guidance...

  19. Mouse-human immunoglobulin G1 chimeric antibodies with activities against Cryptococcus neoformans.

    OpenAIRE

    Zebedee, S L; Koduri, R K; Mukherjee, J; Mukherjee, S.; Lee, S; Sauer, D F; Scharff, M. D.; Casadevall, A

    1994-01-01

    Passive antibody administration is a potentially useful approach for the therapy of human Cryptococcus neoformans infections. To evaluate the efficacy of the human immunoglobulin G1 (IgG1) constant region against C. neoformans and to construct murine antibody derivatives with reduced immunogenicities and longer half-lives in humans, two mouse-human IgG1 chimeric antibodies were generated from the protective murine monoclonal antibodies 2D10 (IgM) and 18B7 (IgG1). The 2D10 mouse-human IgG1 chi...

  20. The protein source in embryo culture media influences birthweight: a comparative study between G1 v5 and G1-PLUS v5.

    Science.gov (United States)

    Zhu, Jinliang; Li, Ming; Chen, Lixue; Liu, Ping; Qiao, Jie

    2014-07-01

    Does protein source or human serum albumin (HSA) in embryo culture media influence the subsequent birthweight? A significant difference was observed in gestational age- and gender-adjusted birthweight (Z scores) and the proportion of large-for-gestational age (LGA) babies between embryos cultured in G1 v5 and those cultured in G1-PLUS v5 media. It has been reported that the birthweights of singletons born from embryos cultured in Vitrolife are significantly higher than those cultured in the Cook group of media, and that G1-PLUS (Vitrolife, Gothenburg, Sweden) is associated with increased birth and placenta weights compared with Medicult ISMI. This study was a retrospective analysis of neonatal birthweights, and included 1097 singletons born from fresh embryo transfer cycles at the Center for Reproductive Medicine of Peking University Third Hospital between January 2011 and August 2012. The number of singletons born from G1 v5 culture media was 489, and the number of singletons born from G1-PLUS v5 media was 608. Patients media groups. The absolute birthweights for singletons resulting from G1-PLUS v5 were not different from singletons resulting from G1 v5 (3375.9 ± 479.6 g versus 3333.2 ± 491.6 g, respectively; P = 0.14). However the Z scores for singletons from embryos cultured in G1-PLUS v5 were significantly higher than for singletons cultured in G1 v5 (0.28 ± 1.12 versus 0.09 ± 1.15, respectively; P = 0.04), and more LGA babies were born from G1-PLUS v5 culture compared with G1 v5 (16.8 versus 12.1%, respectively; P = 0.03) culture. Finally, multiple linear regression analysis suggested that female weight (P = 0.00), male height (P = 0.04), gestational age at birth (P = 0.00), infant gender (P = 0.00) and culture media (P = 0.04) all had significant effects on the birthweights of singleton newborns. This study was limited by its retrospective design. Our study suggests that protein source/HSA has a significant effect on birthweights of singleton newborns

  1. Evaluation of Ammunition Data Cards (REDACTED)

    Science.gov (United States)

    2016-04-29

    the ammunition data card approval process. Train Joint Munitions Command onsite Government representatives on MIL‑STD‑1168C requirements. Commanding...the ammunition data cards comply with MIL‑STD‑1168, the Ammunition‑Data Repository Program User Manual, and contractual requirements. 7. Train DCMA...onsite Government representatives to improve oversight of the ammunition data card approval process. Train DCMA onsite Government representatives on

  2. Fraud management in the credit card industry

    OpenAIRE

    Peter Burns; Anne Stanley

    2002-01-01

    On November 16, 2001, the Payment Cards Center of the Federal Reserve Bank of Philadelphia sponsored a workshop on fraud management in the credit card industry. Daniel Buttafogo and Larry Drexler of Juniper Bank led the discussion. Daniel Buttafogo, Director-Risk Management, is Juniper's fraud expert. He provided an overview of fraud in the card industry and discussed some of the challenges he faces as a risk manager. ; Larry Drexler is General Counsel and the Chief Privacy Officer at Juniper...

  3. Optical smart card using semipassive communication

    Science.gov (United States)

    Glaser, I.; Green, Shlomo; Dimkov, Ilan

    2006-03-01

    An optical secure short-range communication system is presented. The mobile unit (optical smart card) of this system utilizes a retroreflector with an optical modulator, using light from the stationary unit; this mobile unit has very low power consumption and can be as small as a credit card. Such optical smart cards offer better security than RF-based solutions, yet do not require physical contact. Results from a feasibility study model are included.

  4. Augmenting C-cards with music actions

    DEFF Research Database (Denmark)

    Jensen, Karl Kristoffer; Valente, Andrea; Lyon, Kirstin Catherine

    2006-01-01

    The paper proposes a new way of introducing music to classes of 8 to 10 years old pupils, by adopting a recent educational tool for teaching Computer Science. Our proposal builds in fact on computational cards (or c-cards), a playful and intuitive mind-tool, that has been applied to a variety...... of Computer Science concepts. Here a simple extension to c-cards is presented, that enables pupils to build and play with tangible musical machine....

  5. Falla cardíaca (primera parte)

    OpenAIRE

    Flórez Alarcón, Noel Alberto; Fundación Valle de Lili

    2006-01-01

    Anatomía y función del corazón/¿Qué es la falla cardíaca?/Causas de falla cardíaca/¿Cómo prevenir la falla cardíaca?/¿Qué es un factor de riesgo?/¿Cuáles son los síntomas y signos de la falla cardiaca?/¿Cómo se diagnostica la falla cardiaca?

  6. C-cards in Music Education

    DEFF Research Database (Denmark)

    Valente, Andrea; Lyon, Kirstin Catherine

    2005-01-01

    The paper proposes a new way of introducing music to classes of 8 to 10 years old pupils, by adopting a recent educational tool for teaching Computer Science. Our proposal builds in fact on computational cards (or c-cards), a playful and intuitive mind-tool, that has been applied to a variety...... of Computer Science concepts. Here a simple extension to c-cards is presented, that enables pupils to build and play with tangible musical machine....

  7. EFFECT OF FLAT SPEED OF CARDING MACHINE ON QUALITY OF CARD SLIVER AND YARN

    OpenAIRE

    A. Subrata Kumar Saha; B. Jamal Hossen; C. Chowdhury Jony Moin

    2011-01-01

    Carding is the first and only machine (in card process) which can eliminate neps, seed coat neps and the remaining impurities which cannot be eliminated by blowroom section. In case of carding machine the higher the production rate, the more sensitive the carding operation and the greater danger of negative influence onquality. So the optimization of speed is the prime factor today [1]. Excessive higher speed can lead to fiberdamage and higher neps generation which will downgrade the final pr...

  8. Java Card: An analysis of the most successful smart card operating system

    NARCIS (Netherlands)

    de Jong, Eduard; Hartel, Pieter H.; Peyret, Patrice; Cattaneo, Peter

    2005-01-01

    To explain why the Java Card operating system has become the most successful smart card operating system to date, we analyze the realized features of the current Java Card version, we argue it could be enhanced by adding a number of intended features and we discuss a set of complementary features

  9. The "Negative" Credit Card Effect: Credit Cards as Spending-Limiting Stimuli in New Zealand

    Science.gov (United States)

    Lie, Celia; Hunt, Maree; Peters, Heather L.; Veliu, Bahrie; Harper, David

    2010-01-01

    The "credit card effect" describes a finding where greater value is given to consumer items if credit card logos are present. One explanation for the effect is that credit cards elicit spending behavior through associative learning. If this is true, social, economic and historical contexts should alter this effect. In Experiment 1, Year…

  10. Smart Cards 101: Everything a Beginner Needs To Get Started.

    Science.gov (United States)

    Wiens, Janet

    2001-01-01

    Discusses how to implement a smart card system at a college or university, and explains what smart cards are, their potential applications, benefits, and costs. Provides a resource for obtaining additional information about smart cards. (GR)

  11. A Simple Homemade Polarised Sunglasses Test Card

    Science.gov (United States)

    Bamdad, Farzad

    2016-01-01

    In this article construction of a simple and inexpensive test card which can be used to demonstrate the polarisation ability of sunglasses is described. The card was fabricated simply by using a piece of polariser sheet with one to three layers of cellophane tape fixed on it.

  12. Establishing a Successful Smart Card Program.

    Science.gov (United States)

    Wiens, Janet

    2001-01-01

    Discusses how to run a successful smart card program through a comprehensive approach that includes a detailed plan for the present and future, high level support from school administration, and extensive user input. Florida State University is used to illustrate a successfully implemented smart card program. (GR)

  13. C-cards in Music Education

    DEFF Research Database (Denmark)

    Valente, Andrea; Lyon, Kirstin Catherine

    as computational elements. Computing machines can be defined, physically built and animated by disposing cards on a table, and moving objectified symbols on top of them, following formal rules. We provide each card with one associated action. The action is performed each time a peg lands on one of the four ports...

  14. Enhancing Students' Learning: Instant Feedback Cards

    Science.gov (United States)

    Mohrweis, Lawrence C.; Shinham, Kathe M.

    2015-01-01

    This study illustrates an active learning approach using instant feedback cards in the first course in accounting. The objectives of this study are to (1) describe instant feedback cards and (2) show how this tool, when used in an active learning environment, can enhance learning. We examined whether students exposed to immediate feedback…

  15. Cognitive Credit Cards: Acquiring Learning Strategies.

    Science.gov (United States)

    Edmunds, Alan L.

    1999-01-01

    Describes the Cognitive Credit Card, an individualized approach to helping students with learning disabilities select and apply appropriate learning strategies. The CCC is a credit card-sized laminated set of cognitive or metacognitive cues for a specific topic. Feedback from students, teachers, and parents has been highly positive. (DB)

  16. Mammography screening credit card and compliance.

    Science.gov (United States)

    Schapira, D V; Kumar, N B; Clark, R A; Yag, C

    1992-07-15

    Screening for breast cancer using mammography has been shown to be effective in reducing mortality from breast cancer. The authors attempted to determine if use of a wallet-size plastic screening "credit" card would increase participants' compliance for subsequent mammograms when compared with traditional methods of increasing compliance. Two hundred and twenty consecutive women, ages 40-70 years, undergoing their first screening mammography were recruited and assigned randomly to four groups receiving (1) a reminder plastic credit card (2) reminder credit card with written reminder; (3) appointment card; and (4) verbal recommendation. Return rates of the four groups were determined after 15 months. The return rate for subsequent mammograms was significantly higher for participants (72.4%) using the credit card than for participants (39.8%) exposed to traditional encouragement/reminders (P less than 0.0001). The credit card was designed to show the participant's screening anniversary, and the durability of the card may have been a factor in increasing the return rate. The use of reminder credit cards may increase compliance for periodic screening examinations for other cancers and other chronic diseases.

  17. College Student Performance and Credit Card Usage.

    Science.gov (United States)

    Pinto, Mary Beth; Parente, Diane H.; Palmer, Todd Starr

    2001-01-01

    Examines the relationship between credit card usage, employment, and academic performance among a group of college students with credit cards. Results reveal that the students differed significantly in the level of anxiety felt from carrying debt, perceived need to work, and perceived impact of employment on academic performance. (Contains 57…

  18. Payment Card Rewards Programs and Consumer Payment Choice

    OpenAIRE

    Ching, Andrew; Hayashi, Fumiko

    2008-01-01

    Card payments have been growing very rapidly. To continue the growth, payment card networks keep adding new merchants and card issuers try to stimulate their existing customers’ card usage by providing rewards. This paper seeks to analyze the effects of payment card rewards programs on consumer payment choice, by using consumer survey data. Specifically, we examine whether credit/debit reward receivers use credit/debit cards relatively more often than other consumers, if so how much more ofte...

  19. Immunoglobulin G1 Allotype Influences Antibody Subclass Distribution in Response to HIV gp140 Vaccination

    Directory of Open Access Journals (Sweden)

    Sven Kratochvil

    2017-12-01

    Full Text Available Antibody subclasses exhibit extensive polymorphisms (allotypes that could potentially impact the quality of HIV-vaccine induced B cell responses. Allotypes of immunoglobulin (Ig G1, the most abundant serum antibody, have been shown to display altered functional properties in regard to serum half-life, Fc-receptor binding and FcRn-mediated mucosal transcytosis. To investigate the potential link between allotypic IgG1-variants and vaccine-generated humoral responses in a cohort of 14 HIV vaccine recipients, we developed a novel protocol for rapid IgG1-allotyping. We combined PCR and ELISA assays in a dual approach to determine the IgG1 allotype identity (G1m3 and/or G1m1 of trial participants, using human plasma and RNA isolated from PBMC. The IgG1-allotype distribution of our participants mirrored previously reported results for caucasoid populations. We observed elevated levels of HIV gp140-specific IgG1 and decreased IgG2 levels associated with the G1m1-allele, in contrast to G1m3 carriers. These data suggest that vaccinees homozygous for G1m1 are predisposed to develop elevated Ag-specific IgG1:IgG2 ratios compared to G1m3-carriers. This elevated IgG1:IgG2 ratio was further associated with higher FcγR-dimer engagement, a surrogate for potential antibody-dependent cellular cytotoxicity (ADCC and antibody-dependent cellular phagocytosis (ADCP function. Although preliminary, these results suggest that IgG1 allotype may have a significant impact on IgG subclass distribution in response to vaccination and associated Fc-mediated effector functions. These results have important implications for ongoing HIV vaccine efficacy studies predicated on engagement of FcγR-mediated cellular functions including ADCC and ADCP, and warrant further investigation. Our novel allotyping protocol provides new tools to determine the potential impact of IgG1 allotypes on vaccine efficacy.

  20. Protein elicitor PemG1 from Magnaporthe grisea induces systemic acquired resistance (SAR) in plants.

    Science.gov (United States)

    Peng, Dong-Hai; Qiu, De-Wen; Ruan, Li-Fang; Zhou, Chen-Fei; Sun, Ming

    2011-10-01

    Elicitors can stimulate defense responses in plants and have become a popular strategy in plant disease control. Previously, we isolated a novel protein elicitor, PemG1, from Magnaporthe grisea. In the present study, PemG1 protein expressed in and purified from Escherichia coli improved resistance of rice and Arabidopsis to bacterial infection, induced transient expression of pathogenesis-related (PR) genes, and increased accumulation of hydrogen peroxide in rice. The effects of PemG1 on disease resistance and PR gene expression were mobilized systemically throughout the rice plant and persisted for more than 28 days. PemG1-induced accumulation of OsPR-1a in rice was prevented by the calcium channel blockers LaCl₃, BAPTA, EGTA, W7, and TFP. Arabidopsis mutants that are insensitive to jasmonic acid (JA) and ethylene showed increased resistance to bacterial infection after PemG1 treatment but PemG1 did not affect resistance of mutants with an impaired salicylic acid (SA) transduction pathway. In rice, PemG1 induced overexpressions of the SA signal-related genes (OsEDS1, OsPAL1, and OsNH1) but not the JA pathway-related genes (OsLOX2 and OsAOS2). Our findings reveal that PemG1 protein can function as an activator of plant disease resistance, and the PemG1-mediated systemic acquired resistance is modulated by SA- and Ca(2+)-related signaling pathways.

  1. Card - Electronic Money. Comparative Study

    Directory of Open Access Journals (Sweden)

    Mariana Rodica TIRLEA

    2012-11-01

    Full Text Available This type of coin and appeared as a result of the needs for a proper management of the financial resources available in the market, but also to improve the payments system in our country. The card is an alternative to the conventional instruments of payment is a payment instrument with and without cash by means of which the holder disposes of the current account. It is a standardized, secure information and individualized, through which you can perform operations of cash withdrawal, payment for the goods or services purchased, payment obligations by the public administration authorities and funds transfers between accounts, other than those ordered and executed by financial institutions, carried out through the electronic payment instrument.

  2. Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis

    DEFF Research Database (Denmark)

    Aszodi, Attila; Hunziker, Ernst B; Brakebusch, Cord

    2003-01-01

    -actin organization. In addition, mutant chondrocytes show decreased proliferation caused by a defect in G1/S transition and cytokinesis. The G1/S defect is, at least partially, caused by overexpression of Fgfr3, nuclear translocation of Stat1/Stat5a, and up-regulation of the cell cycle inhibitors p16 and p21...

  3. 26 CFR 1.45G-1 - Railroad track maintenance credit.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Railroad track maintenance credit. 1.45G-1... TAXES Rules for Computing Credit for Investment in Certain Depreciable Property § 1.45G-1 Railroad track maintenance credit. (a) In general. For purposes of section 38, the railroad track maintenance credit (RTMC...

  4. A hyperactive transcriptional state marks genome reactivation at the mitosis-G1 transition.

    Science.gov (United States)

    Hsiung, Chris C-S; Bartman, Caroline R; Huang, Peng; Ginart, Paul; Stonestrom, Aaron J; Keller, Cheryl A; Face, Carolyne; Jahn, Kristen S; Evans, Perry; Sankaranarayanan, Laavanya; Giardine, Belinda; Hardison, Ross C; Raj, Arjun; Blobel, Gerd A

    2016-06-15

    During mitosis, RNA polymerase II (Pol II) and many transcription factors dissociate from chromatin, and transcription ceases globally. Transcription is known to restart in bulk by telophase, but whether de novo transcription at the mitosis-G1 transition is in any way distinct from later in interphase remains unknown. We tracked Pol II occupancy genome-wide in mammalian cells progressing from mitosis through late G1. Unexpectedly, during the earliest rounds of transcription at the mitosis-G1 transition, ∼50% of active genes and distal enhancers exhibit a spike in transcription, exceeding levels observed later in G1 phase. Enhancer-promoter chromatin contacts are depleted during mitosis and restored rapidly upon G1 entry but do not spike. Of the chromatin-associated features examined, histone H3 Lys27 acetylation levels at individual loci in mitosis best predict the mitosis-G1 transcriptional spike. Single-molecule RNA imaging supports that the mitosis-G1 transcriptional spike can constitute the maximum transcriptional activity per DNA copy throughout the cell division cycle. The transcriptional spike occurs heterogeneously and propagates to cell-to-cell differences in mature mRNA expression. Our results raise the possibility that passage through the mitosis-G1 transition might predispose cells to diverge in gene expression states. © 2016 Hsiung et al.; Published by Cold Spring Harbor Laboratory Press.

  5. Acrocentric Chromosomes in Cultured Leukocytes from Mothers of Children Affected With the G1- Trisomy Syndrome

    Science.gov (United States)

    And Others; Cotton, James E.

    1973-01-01

    Analysis of venous blood samples from 24 mothers of G1-trisomy-affected (Down's Syndrome) children and 23 mothers of chromosomally normal children indicated that mothers of G1-trisomy-affected children had a greater than expected involvement of the G-chromosomes in associations of acrocentric satellited (chromosome configuration) chromosomes.…

  6. WHAT INFLUENCE CREDIT CARD DEBTS IN YOUNG CONSUMERS IN MALAYSIA

    Directory of Open Access Journals (Sweden)

    Syed Shah ALAM

    2014-12-01

    Full Text Available This paper examines empirically antecedents of the credit card debts in young consumers in Malaysia. We examine whether easy access to credit card, credit card related knowledge, aggressive promotion by credit card industry, low minimum payment requirement and attitude towards credit cards influence credit card debts in the younger generation. Regression model was used to meet the objectives. These findings based on a sample of 240 young credit card holders, show that the factors that affect credit card debts are credit card related knowledge, aggressive promotion by credit card industry and low minimum payment requirements. These findings also provide insights for both bank management and policy-makers to improve the bank performance in terms of credit card debts.

  7. Msa1 and Msa2 Modulate G1-Specific Transcription to Promote G1 Arrest and the Transition to Quiescence in Budding Yeast.

    Directory of Open Access Journals (Sweden)

    Shawna Miles

    2016-06-01

    Full Text Available Yeast that naturally exhaust their glucose source can enter a quiescent state that is characterized by reduced cell size, and high cell density, stress tolerance and longevity. The transition to quiescence involves highly asymmetric cell divisions, dramatic reprogramming of transcription and global changes in chromatin structure and chromosome topology. Cells enter quiescence from G1 and we find that there is a positive correlation between the length of G1 and the yield of quiescent cells. The Swi4 and Swi6 transcription factors, which form the SBF transcription complex and promote the G1 to S transition in cycling cells, are also critical for the transition to quiescence. Swi6 forms a second complex with Mbp1 (MBF, which is not required for quiescence. These are the functional analogues of the E2F complexes of higher eukaryotes. Loss of the RB analogue, Whi5, and the related protein Srl3/Whi7, delays G1 arrest, but it also delays recovery from quiescence. Two MBF- and SBF-Associated proteins have been identified that have little effect on SBF or MBF activity in cycling cells. We show that these two related proteins, Msa1 and Msa2, are specifically required for the transition to quiescence. Like the E2F complexes that are quiescence-specific, Msa1 and Msa2 are required to repress the transcription of many SBF target genes, including SWI4, the CLN2 cyclin and histones, specifically after glucose is exhausted from the media. They also activate transcription of many MBF target genes. msa1msa2 cells fail to G1 arrest and rapidly lose viability upon glucose exhaustion. msa1msa2 mutants that survive this transition are very large, but they attain the same thermo-tolerance and longevity of wild type quiescent cells. This indicates that Msa1 and Msa2 are required for successful transition to quiescence, but not for the maintenance of that state.

  8. Role of HLA-G1 in trophoblast cell proliferation, adhesion and invasion

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Feng, E-mail: jiangfeng1161@163.com [Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, 569 Xinsi Road, Baqiao District, Xi' an 710038 (China); Zhao, Hongxi [Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, 569 Xinsi Road, Baqiao District, Xi' an 710038 (China); Wang, Li [Department of Gynecology and Obstetrics, The Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853 (China); Guo, Xinyu [Assisted Reproductive Center, General Hospital of Guangzhou Military Command, Guangzhou 510010 (China); Wang, Xiaohong; Yin, Guowu [Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, 569 Xinsi Road, Baqiao District, Xi' an 710038 (China); Hu, Yunsheng [Department of Orthopedics, Tangdu Hospital, The Fourth Military Medical University, Xi' an 710038 (China); Li, Yi [Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, 569 Xinsi Road, Baqiao District, Xi' an 710038 (China); Yao, Yuanqing, E-mail: yuanqingyaoxa@163.com [Department of Gynecology and Obstetrics, The Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853 (China)

    2015-02-27

    Trophoblast cells are important in embryo implantation and fetomaternal tolerance. HLA-G is specifically expressed at the maternal–fetal interface and is a regulator in pregnancy. The aim of the present study was to detect the effect of HLA-G1 on trophoblast cell proliferation, adhesion, and invasion. Human trophoblast cell lines (JAR and HTR-8/SVneo cells) were infected with HLA-G1-expressing lentivirus. After infection, HLA-G1 expression of the cells was detected by western blotting. Cell proliferation was detected by the BrdU assay. The cell cycle and apoptosis of JAR and HTR-8/SVneo cells was measured by flow cytometry (FCM). The invasion of the cells under different conditions was detected by the transwell invasion chamber assay. HLA-G1 didn't show any significant influence on the proliferation, apoptosis, adhesion, and invasion of trophocytes in normal culture conditions. However, HLA-G1 inhibited JAR and HTR-8/SVneo cells invasion induced by hepatocyte growth factor (HGF) under normal oxygen conditions. In conditions of hypoxia, HLA-G1 couldn't inhibit the induction of cell invasion by HGF. HLA-G1 is not an independent factor for regulating the trophocytes. It may play an indirect role in embryo implantation and formation of the placenta. - Highlights: • HLA-G1 could not influence trophocytes under normal conditions. • HLA-G1 inhibited cell invasion induced by HGF under normal oxygen condition. • HLA-G1 could not influence cell invasion under hypoxia conditions.

  9. Recognition of the smart card iconic numbers

    Directory of Open Access Journals (Sweden)

    Xin Xue Shi

    2016-01-01

    Full Text Available Manual way of recognizing and inputting the smart card iconic numbers leads to much time consuming, high resources consuming and low accuracy. This paper presents a new automatic method based on the technology of computer vision, including Harr operator for face detection, Fast operator for number location, image binarization, character segmentation and BP neural network for number recognition. Experimental results on 100 ID cards show that by adjusting the parameters of the BP neural network properly, the recognition accuracy is more than 99%, and the recognition time for each ID card is within 0.05 seconds.

  10. PERIOD OF VALIDITY OF CERN CARDS

    CERN Multimedia

    Relations with the Host States Service

    2002-01-01

    Reminder The period of validity of CERN cards not bearing an expiry date has been extended from 30 June to 31 December 2002 (see paragraph 17.4 of the Implementation Measures relating to Operational Circular n° 2). Holders of such cards are kindly requested to have their cards renewed either at the Users Office (in the case of Users) or at the Registration Service (all the others) from 1 August 2002 onwards. Relations with the Host States Service http://www.cern.ch/relations/ Tel. 72848

  11. Caquexia cardíaca Cardiac cachexia

    OpenAIRE

    Alberto Miján; Elvira Martín; Beatriz de Mateo

    2006-01-01

    La insuficiencia cardíaca de carácter crónico (ICC), en especial si afecta al corazón derecho, ocasiona con frecuencia malnutrición. Si esta es grave y se unen otros componentes, puede producirse caquexia cardíaca. Esta se asocia a mayor morbilidad y menor supervivencia de los pacientes que la padecen. Las causas de la caquexia cardíaca son diversas, en general asociadas a mantener balance energético negativo, surgiendo cada vez mayor evidencia que apoya un origen multifactorial de la misma. ...

  12. Loyalty Card Promotional Activity in Budget Hotel

    OpenAIRE

    Teng, Fei

    2010-01-01

    Loyalty card is one of the most commonly used promotional activities in business. Thus far, there are some research has been done on luxury hotel, but very few researches are on budget hotel. So, the purpose of the thesis is finding out the Swedish customers’ attitude and behavior towards budget hotel’s loyalty card; getting to know what factors influence Swedish customers’ response towards the loyalty card and budget hotels. In the thesis, the main research problem is “How do Swedish custome...

  13. SD card projects using the PIC microcontroller

    CERN Document Server

    Ibrahim, Dogan

    2010-01-01

    PIC Microcontrollers are a favorite in industry and with hobbyists. These microcontrollers are versatile, simple, and low cost making them perfect for many different applications. The 8-bit PIC is widely used in consumer electronic goods, office automation, and personal projects. Author, Dogan Ibrahim, author of several PIC books has now written a book using the PIC18 family of microcontrollers to create projects with SD cards. This book is ideal for those practicing engineers, advanced students, and PIC enthusiasts that want to incorporate SD Cards into their devices. SD cards are che

  14. Gene expression profiles of HLA-G1 overexpressed in hES cells.

    Science.gov (United States)

    Zhu, Yajing; Zhao, Sanjun; Zhao, Hongxi; Yao, Yuanqing

    2012-10-01

    The goals of this study were to analyze the change in the global gene expression profile of exogenous human leukocyte antigen-G1 (HLA-G1) overexpressed in human embryonic stem (hES) cells and to explore the molecular mechanism by which the overexpression of HLA-G1 modifies immunologic pathways. Microarray and quantitative real-time PCR analyses were performed to quantify the differential expression pattern of HLA-G1 + H1 hES cells. The results showed that HLA-G1 differentially regulated the expression of 425 genes with at least a twofold increase or decrease. These differentially expressed genes were classified into 13 functional groups, including cellular components, biological processes, and molecular functions. The pathways of focal adhesion, the TGF-β signaling pathway, and the immune response were the most predominantly affected. The synergism of these genes could explain the mechanism of the immunosuppression of HLA-G1 + H1 hES cells. Thus, the expression pattern reflected a broad spectrum of roles of HLA-G1 in hES cells.

  15. Role of HLA-G1 in trophoblast cell proliferation, adhesion and invasion.

    Science.gov (United States)

    Jiang, Feng; Zhao, Hongxi; Wang, Li; Guo, Xinyu; Wang, Xiaohong; Yin, Guowu; Hu, Yunsheng; Li, Yi; Yao, Yuanqing

    2015-02-27

    Trophoblast cells are important in embryo implantation and fetomaternal tolerance. HLA-G is specifically expressed at the maternal-fetal interface and is a regulator in pregnancy. The aim of the present study was to detect the effect of HLA-G1 on trophoblast cell proliferation, adhesion, and invasion. Human trophoblast cell lines (JAR and HTR-8/SVneo cells) were infected with HLA-G1-expressing lentivirus. After infection, HLA-G1 expression of the cells was detected by western blotting. Cell proliferation was detected by the BrdU assay. The cell cycle and apoptosis of JAR and HTR-8/SVneo cells was measured by flow cytometry (FCM). The invasion of the cells under different conditions was detected by the transwell invasion chamber assay. HLA-G1 didn't show any significant influence on the proliferation, apoptosis, adhesion, and invasion of trophocytes in normal culture conditions. However, HLA-G1 inhibited JAR and HTR-8/SVneo cells invasion induced by hepatocyte growth factor (HGF) under normal oxygen conditions. In conditions of hypoxia, HLA-G1 couldn't inhibit the induction of cell invasion by HGF. HLA-G1 is not an independent factor for regulating the trophocytes. It may play an indirect role in embryo implantation and formation of the placenta. Copyright © 2015 Elsevier Inc. All rights reserved.

  16. Railway services using contactless smart cards. Hisesshoku IC card wo mochiita tetsudo service

    Energy Technology Data Exchange (ETDEWEB)

    Miki, S. (East Japan Railway Co., Tokyo (Japan))

    1993-07-10

    This paper discusses a role of contactless IC (integrated circuit) cards (smart cards) in the railway services. Tickets for taking trains and reserving seats have function as contract and function of guidance. In this paper, smart cards are recognized as tickets with contract function and guidance function. The guidance function includes static guidance, dynamic guidance, cab information service, guidance of personal information, and interactive guidance. The development status of contactless smart cards is described. The development examples of contactless smart cards are illustrated for bus traffics in Helsinki, subways in London, and Japan's railways. As contactless ticket system, are described the prepaid system, which is based upon the current institution, and the deferred payment system, which imagines credit tickets. Furthermore, problems of contactless smart cards are extracted, as for price, indication, standardization, and security. 6 refs., 4 figs., 1 tab.

  17. Thermal transfer structures coupling electronics card(s) to coolant-cooled structure(s)

    Science.gov (United States)

    David, Milnes P; Graybill, David P; Iyengar, Madhusudan K; Kamath, Vinod; Kochuparambil, Bejoy J; Parida, Pritish R; Schmidt, Roger R

    2014-12-16

    Cooling apparatuses and coolant-cooled electronic systems are provided which include thermal transfer structures configured to engage with a spring force one or more electronics cards with docking of the electronics card(s) within a respective socket(s) of the electronic system. A thermal transfer structure of the cooling apparatus includes a thermal spreader having a first thermal conduction surface, and a thermally conductive spring assembly coupled to the conduction surface of the thermal spreader and positioned and configured to reside between and physically couple a first surface of an electronics card to the first surface of the thermal spreader with docking of the electronics card within a socket of the electronic system. The thermal transfer structure is, in one embodiment, metallurgically bonded to a coolant-cooled structure and facilitates transfer of heat from the electronics card to coolant flowing through the coolant-cooled structure.

  18. 12 CFR 226.12 - Special credit card provisions.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Special credit card provisions. 226.12 Section... SYSTEM TRUTH IN LENDING (REGULATION Z) Open-End Credit § 226.12 Special credit card provisions. (a) Issuance of credit cards. Regardless of the purpose for which a credit card is to be used, including...

  19. SC2: Secure Communication over Smart Cards

    DEFF Research Database (Denmark)

    Dragoni, Nicola; Lostal, Eduardo; Papini, Davide

    2012-01-01

    The Security-by-Contract (S×C) framework has recently been proposed to support software evolution in open multi-application smart cards. The key idea lies in the notion of contract, a specification of the security behavior of an application that must be compliant with the security policy...... of the card hosting the application. In this paper we address a key issue to realize the S×C idea, namely the outsourcing of the contractpolicy matching service to a Trusted Third Party (TTP). In particular, we present the design and implementation of (SC)2 (Secure Communication over Smart Cards), a system...... securing the communication between a smart card and the TTP which provides the S×C matching service....

  20. EuCARD final project report

    CERN Document Server

    Koutchouk, J P

    2014-01-01

    After four years of activity, EuCARD has most of its objectives fulfilled, with some new objectives added and a few others on excellent tracks while requiring additional time. The management has been active in reinforcing the collaborative links between partners and projects, contributing to the preparation of FP7-EuCARD2, initiating FP7-HiLumi-LHC Design Study, to favour sustained collaborations beyond EuCARD. An out-of-contract network has been successfully launched on laser plasma acceleration, to combine forces between accelerator, laser and plasma communities. Communication and dissemination activities have led to two highlights: Accelerating News, an accelerator R&D newsletter initiated by EuCARD and now common to all FP7 accelerator projects (over 1000 subscribers) and a series of monographs on accelerator sciences that is progressively finding its public. The scientific networks have more than fulfilled their initial objectives: roadmaps are defined for neutrino facilities, submitted to the Europe...

  1. FRENCH CARDS - NEW PROCEDURE FOR INITIAL APPLICATION

    CERN Multimedia

    Human Resources Division

    2002-01-01

    The Human Resources Division would like to remind members of personnel that they are obliged to submit an application form for a French card as soon as they have a permanent address in either Switzerland or in France and they are actually living there. Following the rationalization of our administrative procedures, as of October 1st, 2002, the initial application procedure for a French card will now be as follows: The member of personnel should complete an application form. If necessary, an application form must also be completed for family members. These forms must then be transferred via e-mail to the appropriate Divisional Administrative Officer (DAO) who will forward them to the Cards Service. In parallel, the member of personnel should submit the necessary supporting documents to the Cards Service. The application form (Word format only), the procedural details, the necessary supporting documents as well as the conditions of issue are available here.   Human Resources Division Tel. 74469

  2. College Student Credit Card Usage and Debt.

    Science.gov (United States)

    Rybka, Kathryn M.

    2001-01-01

    Provides an overview of the concerns related to credit card usage by college students. Offers information student affairs professionals can use to help college students make responsible choices. (Contains 26 references.) (GCP)

  3. Prefrontal system dysfunction and credit card debt.

    Science.gov (United States)

    Spinella, Marcello; Yang, Bijou; Lester, David

    2004-10-01

    Credit card use often involves a disadvantageous allocation of finances because they allow for spending beyond means and buying on impulse. Accordingly they are associated with increased bankruptcy, anxiety, stress, and health problems. Mounting evidence from functional neuroimaging and clinical studies implicates prefrontal-subcortical systems in processing financial information. This study examined the relationship of credit card debt and executive functions using the Frontal System Behavior Scale (FRSBE). After removing the influences of demographic variables (age, sex, education, and income), credit card debt was associated with the Executive Dysfunction scale, but not the Apathy or Disinhibition scales. This suggests that processes of conceptualizing and organizing finances are most relevant to credit card debt, and implicates dorsolateral prefrontal dysfunction.

  4. Assistance with Obtaining a Replacement Card Form

    Science.gov (United States)

    Form to be submitted to Section 608 Technician Certification Program Manager if a technician wants to replace a certification card, and the record of the original certification is in the data submitted by companies that have gone out of business.

  5. Notification: Purchase Card and Convenience Check Audit

    Science.gov (United States)

    Project #OA-FY13-0116, April 11, 2013. The U.S. Environmental Protection Agency, Office of Inspector General, is beginning the fieldwork phase of its audit of the agency’s purchase card and convenience check programs.

  6. Control of cell cycle transcription during G1 and S phases.

    Science.gov (United States)

    Bertoli, Cosetta; Skotheim, Jan M; de Bruin, Robertus A M

    2013-08-01

    The accurate transition from G1 phase of the cell cycle to S phase is crucial for the control of eukaryotic cell proliferation, and its misregulation promotes oncogenesis. During G1 phase, growth-dependent cyclin-dependent kinase (CDK) activity promotes DNA replication and initiates G1-to-S phase transition. CDK activation initiates a positive feedback loop that further increases CDK activity, and this commits the cell to division by inducing genome-wide transcriptional changes. G1-S transcripts encode proteins that regulate downstream cell cycle events. Recent work is beginning to reveal the complex molecular mechanisms that control the temporal order of transcriptional activation and inactivation, determine distinct functional subgroups of genes and link cell cycle-dependent transcription to DNA replication stress in yeast and mammals.

  7. Redox-mediated bypass of restriction point via skipping of G1pm

    Directory of Open Access Journals (Sweden)

    Greene James J

    2006-07-01

    Full Text Available Abstract Background It is well known that cancer cells bypass the restriction point, R, and undergo uncontrolled cell proliferation. Hypothesis and evidence We suggest here that fibrosarcoma cells enter G1ps directly from M, skipping G1pm, hence bypassing R, in response to redox modulation. Evidence is presented from the published literature that demonstrate a shortening of the cycle period of transformed fibroblasts (SV-3T3 compared to the nontransformed 3T3 fibroblasts, corresponding to the duration of G1pm in the 3T3 fibroblasts. Evidence is also presented that demonstrate that redox modulation can induce the CUA-4 fibroblasts to bypass R, resulting in a cycle period closely corresponding to the cycle period of fibrosarcoma cells (HT1080. Conclusion The evidence supports our hypothesis that a low internal redox potential can cause fibrosarcoma cells to skip the G1pm phase of the cell cycle.

  8. Smart Card Payment metering gas and electricity

    Energy Technology Data Exchange (ETDEWEB)

    Lee, D.L. [Landis and Gyr (United Kingdom) Ltd., Telford, (United Kingdom); Kriby, R. [Midlands Electricity plc, Kingswinford, (United Kingdom)

    1995-12-31

    Utilities, both gas and electricity, require and operate a variety of regular payment facilities. The range used by any particular utility is primarily a result of history and usually reflects the maturity of customer car and/or regulatory policies. This paper outlines the use of smart card metering, not to be confused with pre-payment metering, which establishes an enhanced level of service to both the customer and utility through the implementation of a simple 2 way communication system. The infrastructure of the smart card system is similar to that used for a token based system, with the smart card used to replace the token for credit transfer to the meter. It involves the use of a customer card which is credited from a Point of Sale (POS), along with the latest tariff details and any messages specific for that customer. These in turn are transferred to the meter when the card is inserted. The current meter readings, readings taken at a particular time and date, and meter status messages are written back to the card for transfer to the POS when credit is next purchased. In the future this infrastructure will be needed irrespective of advances in metering technology, and the Smart card is a secure and convenient way of ensuring correct customer identification and integrity of data. Possibilities are envisaged to extend the use of the system into other payment areas as well as being able to support innovative payment methods in the future. The response from customers, regulatory and welfare bodies, and the staff of the utility is extremely positive and the future of payment systems is considered to be secure in smart card technology. (author).

  9. Prototype ALICE front-end card

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    This circuit board is a prototype 48-channel front end digitizer card for the ALICE time projection chamber (TPC), which takes electrical signals from the wire sensors in the TPC and shapes the data before converting the analogue signal to digital data. A total of 4356 cards will be required to process the data from the ALICE TPC, the largest of this type of detector in the world.

  10. Consumer credit counseling: credit card issuers' perspectives

    OpenAIRE

    Mark Furletti

    2003-01-01

    On Friday, May 23, 2003, the Payment Cards Center hosted a workshop led by collections managers from J.P. Morgan Chase and Juniper Bank. The managers provided the credit card issuers' perspective on the consumer credit counseling industry. The day's discussion complemented an earlier workshop at which representatives from local consumer credit counseling services (CCCS) discussed their business model. After describing the ways in which new market entrants have affected the counseling industry...

  11. Penerapan Sanksi Pidana terhadap Tindak Pidana Carding

    OpenAIRE

    Hartono, Bambang

    2013-01-01

    Carding a crime has been growing rapidly in Indonesia, while the legal system in Indonesia is still a gap and weak surveillance systems for this crime, where law enforcement is still very alarming. The research problem is how the application of criminal sanctions against criminal carding. Methods of research conducted juridical normative, using secondary data, obtained from literature studies and data analysis with qualitative analysis. Based on the results of the study discusses Application ...

  12. Correlates of credit card ownership in men and women.

    Science.gov (United States)

    Yang, Bijou; Lester, David

    2005-06-01

    In a sample of 352 students, correlates of credit card ownership differed by sex. For both men and women, credit card ownership was predicted by their affective attitude toward credit cards. However, whereas for men concern with money as a tactic for gaining power predicted credit card ownership, for women feelings of insecurity about having sufficient money and having a conservative approach to money predicted credit card ownership.

  13. Lovastatin induces G1-phase synchronization of HEC-1-A cells and JEC cells

    Directory of Open Access Journals (Sweden)

    Huimin Shen

    2013-03-01

    Full Text Available Our study investigated lovastatin-induced G1 phase synchronization of HEC-1-A cells and JEC cells and the cell cycle progression after desynchronization of these cells. HEC-1-A cells and JEC cells were treated with by lovastatin and the proportion of cells in G1 phase was detected. Both cell types were incubated with lovastatin and the synchronization was determined. The cell cycle progression of both cell types was investigated. The proportion of Both cell types in G1 phase was 87.87 ± 0.70% and 85.00 ± 0.79%, respectively. At 20 h and 16 h after G1-phase desynchronization, the proportion of cells in S phase reached a maximal level and that in G1 phase was at the minimal level for HEC-1-A cells and JEC cells, respectively. Thus, at 20 h and 16 h after desynchronization, the proportion of cells in S phase was the highest and that in G1 phase the lowest for HEC-1-A cells and JEC cells, respectively.

  14. Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I.

    Science.gov (United States)

    Mallampalli, Rama K; Kaercher, Leah; Snavely, Courtney; Pulijala, Roopa; Chen, Bill B; Coon, Tiffany; Zhao, Jing; Agassandian, Marianna

    2013-10-01

    Cell cycle progression through its regulatory control by changes in intracellular Ca(2+) levels at the G1/S transition mediates cellular proliferation and viability. Ca(2+)/CaM-dependent kinase 1 (CaMKI) appears critical in regulating the assembly of the cyclin D1/cdk4 complex essential for G1 progression, but how this occurs is unknown. Cyclin D1/cdk4 assembly in the early G1 phase is also regulated via binding to p27. Here, we show that a ubiquitin E3 ligase component, F-box protein Fbxl12, mediates CaMKI degradation via a proteasome-directed pathway leading to disruption of cyclin D1/cdk4 complex assembly and resultant G1 arrest in lung epithelia. We also demonstrate that i) CaMKI phosphorylates p27 at Thr(157) and Thr(198) in human cells and at Thr(170) and Thr(197) in mouse cells to modulate its subcellular localization; ii) Fbxl12-induced CaMKI degradation attenuates p27 phosphorylation at these sites in early G1 and iii) activation of CaMKI during G1 transition followed by p27 phosphorylation appears to be upstream to other p27 phosphorylation events, an effect abrogated by Fbxl12 overexpression. Lastly, known inducers of G1 arrest significantly increase Fbxl12 levels in cells. Thus, Fbxl12 may be a previously uncharacterized, functional growth inhibitor regulating cell cycle progression that might be used for mechanism-based therapy. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

  15. On Developing HyperCard Stacks for the Study of Chinese Characters: KanjiCard.

    Science.gov (United States)

    Nakajima, Kazuko

    1988-01-01

    Describes "KanjiCard," an interactive self-tutorial program for beginning students of Japanese to learn Kanji, Chinese characters used in the Japanese language. The Macintosh-developed approach uses "HyperCard" technology, computer-assisted animation, and voice digitizing to achieve enhanced graphic presentation. (Author/CB)

  16. Replication-independent MCB gene induction and deoxyribonucleotide accumulation at G1/S in Saccharomyces cerevisiae.

    Science.gov (United States)

    Koç, Ahmet; Wheeler, Linda J; Mathews, Christopher K; Merrill, Gary F

    2003-03-14

    In Saccharomyces cerevisiae, many genes encoding enzymes involved in deoxyribonucleotide synthesis are expressed preferentially near the G1/S boundary of the cell cycle. The relationship between the induction of deoxyribonucleotide-synthesizing genes, deoxyribonucleoside triphosphate levels, and replication initiation was investigated using factor-synchronized wild-type yeast or dbf4 yeast that are temperature-sensitive for replication initiation. Neither the timing nor extent of gene induction was inhibited when factor-arrested dbf4 cells were released into medium containing the ribonucleotide reductase inhibitor hydroxyurea, which blocks replication fork progression, or were released at 37 degrees C, which blocks replication origin firing. Thus, the induction of deoxyribonucleotide-synthesizing genes at G1/S was fully independent of DNA chain elongation or initiation. Deoxyribonucleoside triphosphate levels increased severalfold at G1/S in wild-type cells and in dbf4 mutants incubated at the non-permissive temperature. Thus, deoxyribonucleoside triphosphate accumulation, like the induction of deoxyribonucleotide-synthesizing genes, was not dependent on replication initiation. Deoxyribonucleoside triphosphate accumulation at G1/S was suppressed in cells lacking Swi6, a transcription factor required for normal cell cycle regulation of deoxyribonucleotide-synthesizing genes. The results suggest that cells use gene induction at G1/S as a mechanism to pre-emptively, rather than reflexively, increase the synthesis of DNA precursors to meet the demand of the replication forks for deoxyribonucleotides.

  17. Selection of G1 Phase Yeast Cells for Synchronous Meiosis and Sporulation.

    Science.gov (United States)

    Stuart, David T

    2017-01-01

    Centrifugal elutriation is a procedure that allows the fractionation of cell populations based upon their size and shape. This allows cells in distinct cell cycle stages can be captured from an asynchronous population. The technique is particularly helpful when performing an experiment to monitor the progression of cells through the cell cycle or meiosis. Yeast sporulation like gametogenesis in other eukaryotes initiates from the G1 phase of the cell cycle. Conveniently, S. cerevisiae arrest in G1 phase when starved for nutrients and so withdrawal of nitrogen and glucose allows cells to abandon vegetative growth in G1 phase before initiating the sporulation program. This simple starvation protocol yields a partial synchronization that has been used extensively in studies of progression through meiosis and sporulation. By using centrifugal elutriation it is possible to isolate a homogeneous population of G1 phase cells and induce them to sporulate synchronously, which is beneficial for investigating progression through meiosis and sporulation. An additionally benefit of this protocol is that cell populations can be isolated based upon size and both large and small cell populations can be tested for progression through meiosis and sporulation. Here we present a protocol for purification of G1 phase diploid cells for examining synchronous progression through meiosis and sporulation.

  18. ORC function in late G1: maintaining the license for DNA replication.

    Science.gov (United States)

    Da-Silva, Lance F; Duncker, Bernard P

    2007-01-15

    The origin recognition complex (ORC) is essential as a scaffold for the assembly of prereplicative complexes (pre-RCs) in G(1) phase of the cell cycle. Some models have proposed that once origins have been licensed for DNA replication, ORC is dispensable for MCM protein association, and ensuing DNA replication. Although budding yeast Orc6 is not needed for origin recognition or binding in vitro, we have recently shown that this ORC subunit is required in late G(1) phase for maintenance of MCMs, and subsequent DNA replication. Further investigation shows that depletion of Orc6 results in displacement of MCM proteins from both early- and late-firing origins, and eventually results in the activation of the Rad53 checkpoint kinase, consistent with incomplete DNA replication. Loss of MCM association at origins may be mediated by the displacement of Mcm10 and/or Orc2 as a consequence of late G(1) Orc6 depletion.

  19. FRENCH CARDS - NEW PROCEDURE FOR INITIAL APPLICATION

    CERN Multimedia

    Human Resources Division

    2002-01-01

    The Human Resources Division would like to remind members of personnel that they are obliged to submit an application form for a French card as soon as they have a permanent address in either Switzerland or in France and they are actually living there. Following the rationalization of our administrative procedures, as of October 1st, 2002, the initial application procedure for a French card will now be as follows: The member of personnel should complete an application form. If necessary, an application form must also be completed for family members. These forms must then be transferred via e-mail to the appropriate Divisional Administrative Officer (DAO) who will forward them to the Cards Service. In parallel, the member of personnel should submit the necessary supporting documents to the Cards Service. Users are requested to apply for a French card through the Users Office. The application form (Word format only), the procedural details, the necessary supporting documents as well as the conditions of issue a...

  20. Differential regulation of the cellular response to DNA double-strand breaks in G1

    DEFF Research Database (Denmark)

    Barlow, Jacqueline H; Lisby, Michael; Rothstein, Rodney

    2008-01-01

    Double-strand breaks (DSBs) are potentially lethal DNA lesions that can be repaired by either homologous recombination (HR) or nonhomologous end-joining (NHEJ). We show that DSBs induced by ionizing radiation (IR) are efficiently processed for HR and bound by Rfa1 during G1, while endonuclease......-induced breaks are recognized by Rfa1 only after the cell enters S phase. This difference is dependent on the DNA end-binding Yku70/Yku80 complex. Cell-cycle regulation is also observed in the DNA damage checkpoint response. Specifically, the 9-1-1 complex is required in G1 cells to recruit the Ddc2 checkpoint...

  1. Human hydatid disease in Peru is basically restricted to Echinococcus granulosus genotype G1.

    Science.gov (United States)

    Santivañez, Saul J; Gutierrez, Ariana M; Rosenzvit, Mara C; Muzulin, Patricia M; Rodriguez, Mary L; Vasquez, Julio C; Rodriguez, Silvia; Gonzalez, Armando E; Gilman, Robert H; Garcia, Hector H

    2008-07-01

    A molecular PCR study using DNA from 21 hydatid cysts was performed to determine which strain type is responsible for human infection in Peru. The mitochondrial cytochrome c oxidase subunit 1 (CO1) gene was amplified in 20 out of 21 samples, revealing that all but 1 sample (19/20, 95%) belonged to the common sheep strain (G1). The remaining samples belonged to the camel strain (G6). The G1 genotype was most frequently found in human cases of cystic hydatid disease (CHD) in Peru. Local control measures should focus primarily on decreasing dog and sheep infection rather than intermediate reservoirs.

  2. Analysis of EIF4G1 in Parkinson's disease among Asians.

    Science.gov (United States)

    Zhao, Yi; Ho, Patrick; Prakash, Kumar-M; Foo, Jia-Nee; Liu, Jian-Jun; Au, Wing-Lok; Tan, Louis C; Tan, Eng-King

    2013-04-01

    Sequence analysis of all the exons of EIF4G1 in 96 Asian patients with Parkinson's disease (PD) did not reveal any pathogenic mutations. A novel coding variant (Pro693Ser) in exon 15 (position 2077) was detected in one PD patient but not in 539 control subjects. Analysis of a coding polymorphic variant (rs2178403) in 1330 subjects revealed similar frequency between control subjects (0.638) and PD patients (0.640). EIF4G1 is an uncommon cause of PD in our Asian cohort. Copyright © 2013 Elsevier Inc. All rights reserved.

  3. CRC-cards for Product Modelling

    DEFF Research Database (Denmark)

    Hvam, Lars; Riis, Jesper; Hansen, Benjamin Loer

    2003-01-01

    This paper describes the CRC (class, responsibility, collaboration) modelling process for building product models. A product model is normally represented in an IT system which contains data, information and knowledge on industrial products and their life cycle properties e.g. manufacturing......, transportation, service and decommissioning. A main challenge when building product models is to collect and document the product related data, information and knowledge in a structured way. CRC cards are index cards (or computerized versions of these) which are used to record proposed classes, the behavior...... of the classes, their responsibilities, and their relationship to other classes (collaboration). CRC modelling gives an effective, low-tech method for domain-experts, programmers and users to work closely together to identify, structure, understand and document a product model. CRC cards were originally...

  4. Neural fraud detection in credit card operations.

    Science.gov (United States)

    Dorronsoro, J R; Ginel, F; Sgnchez, C; Cruz, C S

    1997-01-01

    This paper presents an online system for fraud detection of credit card operations based on a neural classifier. Since it is installed in a transactional hub for operation distribution, and not on a card-issuing institution, it acts solely on the information of the operation to be rated and of its immediate previous history, and not on historic databases of past cardholder activities. Among the main characteristics of credit card traffic are the great imbalance between proper and fraudulent operations, and a great degree of mixing between both. To ensure proper model construction, a nonlinear version of Fisher's discriminant analysis, which adequately separates a good proportion of fraudulent operations away from other closer to normal traffic, has been used. The system is fully operational and currently handles more than 12 million operations per year with very satisfactory results.

  5. Early clinical experience with CardioCard - a credit card-sized electronic patient record.

    Science.gov (United States)

    Bernheim, Alain M; Schaer, Beat A; Kaufmann, Christoph; Brunner-La Rocca, Hanspeter; Moulay-Lakhdar, Nadir; Buser, Peter T; Pfisterer, Matthias E; Osswald, Stefan

    2006-08-19

    CardioCard is a CDROM of credit card size containing medical information on cardiac patients. Patient data acquired during hospital stay are stored in PDF format and secured by a password known to patients only. In a consecutive series of patients, we assessed acceptance and utility of this new information medium. A questionnaire was sent to all patients who had received CardioCard over a one-year period. The questionnaire was returned by 392 patients (73%). 44% of patients had the card with them all the time. The majority of patients (73%) considered the CardioCard useful (8% not useful, 19% no statement) and most (78%) would even agree to bear additional costs. Only 5% worried about data security. In contrast, 44% would be concerned of data transmission via internet. During an observation period of 6 (SD 3) months, data were accessed by 27% of patients and 12% of their physicians. The proportion of card users was lower among older patients: 70 y, 16% and particularly among older women: 61.70 y, 9%; >70 y, 5%. Technical problems during data access occurred in 34%, mostly due to incorrect handling. A majority of patients considered CardioCard as useful and safe. Lack of hardware equipment or insufficient computer knowledge, but not safety issues were the most important limitations. As patients expressed concerns regarding protection of privacy if data were accessible via internet, this would remain a strong limiting factor for online use.

  6. UTILIZAÇÃO DE JAVA CARD COMO PLATAFORMA PARA O DESENVOLVIMENTO DE APLICAÇÕES EM SMART CARD.

    Directory of Open Access Journals (Sweden)

    Lucas Plis Dolce

    2011-12-01

    Full Text Available With the growth of Java Card technology and the increased use of smart cards in the market, demand for the development of applications that run on the cards has risen. These applications need to offerbesides portability, convenience and safety, service quality and high availability for users. This article examines the main concepts of Smart Card technology and use these to develop small applicationsusing the Java Card focusing on the use for control systems where the card would serve as a repository of some data and query tool for larger systems.

  7. The ( G /G, 1/G ) -expansion method for solving nonlinear space ...

    Indian Academy of Sciences (India)

    2016-07-06

    Jul 6, 2016 ... G /G,1/G. ) -expansion method for solving fractional differential equations based on a fractional complex transform. We apply this method for solving space–time fractional Cahn–Allen equation and space–time fractional Klein–Gordon equation. The fractional derivatives are described in the sense.

  8. Positive feedback of G1 cyclins ensures coherent cell cycle entry.

    Science.gov (United States)

    Skotheim, Jan M; Di Talia, Stefano; Siggia, Eric D; Cross, Frederick R

    2008-07-17

    In budding yeast, Saccharomyces cerevisiae, the Start checkpoint integrates multiple internal and external signals into an all-or-none decision to enter the cell cycle. Here we show that Start behaves like a switch due to systems-level feedback in the regulatory network. In contrast to current models proposing a linear cascade of Start activation, transcriptional positive feedback of the G1 cyclins Cln1 and Cln2 induces the near-simultaneous expression of the approximately 200-gene G1/S regulon. Nuclear Cln2 drives coherent regulon expression, whereas cytoplasmic Cln2 drives efficient budding. Cells with the CLN1 and CLN2 genes deleted frequently arrest as unbudded cells, incurring a large fluctuation-induced fitness penalty due to both the lack of cytoplasmic Cln2 and insufficient G1/S regulon expression. Thus, positive-feedback-amplified expression of Cln1 and Cln2 simultaneously drives robust budding and rapid, coherent regulon expression. A similar G1/S regulatory network in mammalian cells, comprised of non-orthologous genes, suggests either conservation of regulatory architecture or convergent evolution.

  9. Nonparametric estimation of the stationary M/G/1 workload distribution function

    DEFF Research Database (Denmark)

    Hansen, Martin Bøgsted

    In this paper it is demonstrated how a nonparametric estimator of the stationary workload distribution function of the M/G/1-queue can be obtained by systematic sampling the workload process. Weak convergence results and bootstrap methods for empirical distribution functions for stationary...

  10. Nonparametric estimation of the stationary M/G/1 workload distribution function

    DEFF Research Database (Denmark)

    Hansen, Martin Bøgsted

    2005-01-01

    In this paper it is demonstrated how a nonparametric estimator of the stationary workload distribution function of the M/G/1-queue can be obtained by systematic sampling the workload process. Weak convergence results and bootstrap methods for empirical distribution functions for stationary...

  11. 10522 ASSESSMENT OF AFLATOXINS B1, B2, G1 AND G2 ...

    African Journals Online (AJOL)

    user

    2013-04-13

    Apr 13, 2013 ... Aflatoxins belong to a group of naturally occurring toxins which contaminate foodstuffs under favourable conditions. Aspergillus flavus and Aspergillus parasiticus produce aflatoxins; the four major aflatoxins which contaminate foodstuffs are B1, B2,. G1 and G2. Maize, groundnuts, rice, wheat and other ...

  12. Human IgG1 antibodies suppress angiogenesis in a target-independent manner

    NARCIS (Netherlands)

    Bogdanovich, Sasha; Kim, Younghee; Mizutani, Takeshi; Yasuma, Reo; Tudisco, Laura; Cicatiello, Valeria; Bastos-Carvalho, Ana; Kerur, Nagaraj; Hirano, Yoshio; Baffi, Judit Z; Tarallo, Valeria; Li, Shengjian; Yasuma, Tetsuhiro; Arpitha, Parthasarathy; Fowler, Benjamin J; Wright, Charles B; Apicella, Ivana; Greco, Adelaide; Brunetti, Arturo; Ruvo, Menotti; Sandomenico, Annamaria; Nozaki, Miho; Ijima, Ryo; Kaneko, Hiroki; Ogura, Yuichiro; Terasaki, Hiroko; Ambati, Balamurali K; Leusen, Jeanette HW; Langdon, Wallace Y; Clark, Michael R; Armour, Kathryn L; Bruhns, Pierre; Verbeek, J Sjef; Gelfand, Bradley D; De Falco, Sandro; Ambati, Jayakrishna

    2016-01-01

    Aberrant angiogenesis is implicated in diseases affecting nearly 10% of the world's population. The most widely used anti-angiogenic drug is bevacizumab, a humanized IgG1 monoclonal antibody that targets human VEGFA. Although bevacizumab does not recognize mouse Vegfa, it inhibits angiogenesis in

  13. Role of signal transduction and actin in G1 phase progression.

    Science.gov (United States)

    van Opstal, Angélique; Bijvelt, Jose J M; Margadant, Coert; Boonstra, Johannes

    2005-01-01

    Progression through the cell cycle of mammalian cells is dependent upon external factors such as growth- and ECM factors. These factors exert their effect predominantly during the G1 phase of the cell cycle. When cells are cultured in suspension or when growth factors are withdrawn from the medium, cells will stop cell cycle progression and enter a quiescent state. Cells will remain in this quiescent state until extracellular conditions change and cells are stimulated to re-enter the cell cycle. This stimulation is mediated by various signal transduction cascades such as the mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol 3-kinase (PI3-kinase) pathway. In Chinese hamster ovary cells at least two serum-dependent points exist during G1 phase that lead to diffent cellular responses. The first point is located immediately after mitosis and is suggested to link with apoptosis. The second point is located in late G1 phase and probably corresponds with cellular differentiation. Signal transduction is mutually related to the cytoskeleton, especially the actin microfilament system. The actin microfilament system influences signal transduction and several signal transduction pathways influence the actin structure. Here we describe the role of the MAPK and PI3-kinase activities and of actin microfilaments in progression through the cell cycle and their role in the two G1 checkpoints.

  14. Human anti-rhesus D IgG1 antibody produced in transgenic plants

    DEFF Research Database (Denmark)

    Bouquin, Thomas; Thomsen, Mads; Nielsen, Leif Kofoed

    2002-01-01

    Transgenic plants represent an alternative to cell culture systems for producing cheap and safe antibodies for diagnostic and therapeutic use. To evaluate the functional properties of a 'plantibody', we generated transgenic Arabidopsis plants expressing full-length human IgG1 against the Rhesus D...

  15. Data of evolutionary structure change: 1N32G-1IQVA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available ain>G 1N32G INKIM---RDGKK e>HHHH --- H...Chain> 1IQVA INKVMRSGGSSKK ...>HHHHH H> ATOM 293 CA ILE A 71 40.019 9.985 12....in> 1N32G QRPER---RAAVR > --- HHHH... 1IQVA AKCYRTKMSFAEA >HHHHH HHHH

  16. Modelling M/G/1 queueing systems with server vacations using ...

    African Journals Online (AJOL)

    The theory of non-Markovian stochastic Petri nets is employed in this paper to derive an alternative method for studying the steady state behaviour of the M/G/1 vacation queueing system with a limited service discipline. Three types of vacation schemes are considered, and sytems with both a finite population and those with ...

  17. Postdose 3 G1 serum neutralizing antibody as correlate of protection for pentavalent rotavirus vaccine.

    Science.gov (United States)

    Liu, G Frank; Hille, Darcy; Kaplan, Susan S; Goveia, Michelle G

    2017-10-03

    Although clinical trials of the pentavalent rotavirus vaccine (RotaTeq®, RV5) have demonstrated efficacy against RV gastroenteritis (RGE) in low and high-income settings, a clear correlate of protection or a measure of immune response that could predict efficacy has yet to be identified. This is the first time that immunogenicity data with both serum neutralized antibody (SNA) titers and anti-RV IgA titers from several clinical efficacy trials were pooled to provide a unique context for evaluating the correlation between immunogenicity and RGE risk or efficacy of RV5. The correlation between immunogenicity and RGE risk is evaluated with data at the individual subject level. The analyses show that higher Postdose 3 (PD3) G1 SNA titers are associated with lower odds of contracting any RGE. The correlation between immunogenicity and efficacy is assessed using aggregated population level data, which shows higher efficacy associated with higher PD3 G1 SNA geometric mean titer (GMT) ratio (between RV5 and placebo) and PD3 serum anti-RV IgA GMT ratio. Among high-income countries, efficacy plateaus over the range of PD3 G1 SNA GMT ratios and PD3 serum anti-RV IgA GMT ratios. From both individual- and population-level analyses, PD3 G1 SNA titers correlated most closely with the RGE risk or efficacy for RV5.

  18. Heavy-traffic analysis for the GI/G/1 queue with heavy-tailed distributions

    NARCIS (Netherlands)

    O.J. Boxma (Onno); J.W. Cohen

    1997-01-01

    textabstractWe consider a $GI/G/1$ queue in which the service time distribution and/or the interarrival time distribution has a heavy tail, i.e., a tail behaviour like $t^{-nu$ with $1

  19. Full genomic analysis of a human rotavirus G1P[8] strain isolated in South Korea.

    Science.gov (United States)

    Cho, Min-Kyu; Jheong, Weon-Hwa; Lee, Sung-Geun; Park, Chul Jong; Jung, Kum Hee; Paik, Soon-Young

    2013-01-01

    A rotavirus G1P[8] strain C1-81 was isolated from a 5-month-old female infant admitted to hospital with fever and severe diarrhea in Incheon, South Korea. To investigate its full genomic relatedness and its group, the full genome of strain C1-81 was determined. Based on a full genome classification system, C1-81 was shown to possess the typical Wa-like genotype constellation: G1-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1. On the basis of sequence similarities, the strain was shown to be the closest related strain to contemporary human rotavirus strains with recent strains isolated in Asia. This C1-81 strain showed the highest degree of nucleic acid similarity (98.8% and 97%) to G1 B4633-03 and P[8] (Thai-1604 and Dhaka8-02), respectively. This is the first report that group A rotavirus was analyzed with G1P[8] in South Korea. The study of the complete genome of the virus will help understanding of the evolution of rotavirus. Copyright © 2012 Wiley Periodicals, Inc.

  20. 26 CFR 1.665(g)-1A - Capital gain distribution.

    Science.gov (United States)

    2010-04-01

    ....665(g)-1A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX... deemed under section 666(a) to be undistributed net income of the trust for all preceding taxable years..., the undistributed net income is the same as income under applicable local law. No income was...

  1. The queue M|G|1 with Markov modulated arrivals and services

    NARCIS (Netherlands)

    Regterschot, G.J.K.; de Smit, J.H.A.

    1986-01-01

    We study an M|G|1 queue in which both the arrival rate and the service time distribution depend on the state of an underlying finite-state Markov chain. The solution is obtained by a matrix factorization method. This leads to results for waiting times and queue lengths both at arrival epochs and in

  2. Authoring of digital games via card games

    DEFF Research Database (Denmark)

    Valente, Andrea; Marchetti, Emanuela

    2014-01-01

    Literature and previous studies show that creative play is easy to emerge when children interact with tangible, low-tech toys and games than with digital games. This paradoxical situation is linked to the long-standing problem of end-users (or players) authoring of digital contents and systems. We...... are to show how card games can represent digital games, how playful play can emerge in card games and digital games, and to begin defining a new way to express game behavior without the use of universal programming languages....

  3. Binding specificity of the G1/S transcriptional regulators in budding yeast.

    Directory of Open Access Journals (Sweden)

    Michael R Harris

    Full Text Available BACKGROUND: G1/S transcriptional regulation in the budding yeast Saccharomyces cerevisiae depends on three main transcriptional components, Swi4, Swi6 and Mbp1. These proteins constitute two transcription factor complexes that regulate over 300 G1/S transcripts, namely SBF (Swi4-Swi6 and MBF (Mbp1-Swi6. SBF and MBF are involved in regulating largely non-overlapping sets of G1/S genes via clearly distinct mechanisms. METHODOLOGY/PRINCIPAL FINDINGS: Here we establish and confirm protein-protein and protein-DNA interactions using specific polyclonal antisera to whole Swi6 and to the C-terminal domains of related proteins Swi4 and Mbp1. Our data confirm the protein-protein binding specificity of Swi4 and Mbp1 to Swi6 but not to each other, and support the binding specificity of the transcriptional inhibitor Whi5 to SBF and of the corepressor Nrm1 to MBF. We also show the DNA binding preference of Swi4 to the CLN2 promoter and Mbp1 to the RNR1 promoter, while Swi6 binds both promoters. Finally, we establish the binding dynamics of Swi4 and Whi5 to the CLN2 promoter during the cell cycle. CONCLUSIONS/SIGNIFICANCE: These data confirm the binding specificity of the G1/S transcriptional regulators. Whereas previous observations were made using tagged Swi4, Swi6 and Mbp1, here we use specific polyclonal antisera to reestablish the protein-protein and protein-DNA interactions of these G1/S transcriptional components. Our data also reveal the dynamic changes in promoter binding of Swi4 during the cell cycle, which suggests a possible positive feedback loop involving Swi4.

  4. Energy transport, polar amplification, and ITCZ shifts in the GeoMIP G1 ensemble

    Directory of Open Access Journals (Sweden)

    R. D. Russotto

    2018-02-01

    Full Text Available The polar amplification of warming and the ability of the Intertropical Convergence Zone (ITCZ to shift to the north or south are two very important problems in climate science. Examining these behaviors in global climate models (GCMs running solar geoengineering experiments is helpful not only for predicting the effects of solar geoengineering but also for understanding how these processes work under increased carbon dioxide (CO2. Both polar amplification and ITCZ shifts are closely related to the meridional transport of moist static energy (MSE by the atmosphere. This study examines changes in MSE transport in 10 fully coupled GCMs in experiment G1 of the Geoengineering Model Intercomparison Project (GeoMIP, in which the solar constant is reduced to compensate for the radiative forcing from abruptly quadrupled CO2 concentrations. In G1, poleward MSE transport decreases relative to preindustrial conditions in all models, in contrast to the Coupled Model Intercomparison Project phase 5 (CMIP5 abrupt4xCO2 experiment, in which poleward MSE transport increases. We show that since poleward energy transport decreases rather than increases, and local feedbacks cannot change the sign of an initial temperature change, the residual polar amplification in the G1 experiment must be due to the net positive forcing in the polar regions and net negative forcing in the tropics, which arise from the different spatial patterns of the simultaneously imposed solar and CO2 forcings. However, the reduction in poleward energy transport likely plays a role in limiting the polar warming in G1. An attribution study with a moist energy balance model shows that cloud feedbacks are the largest source of uncertainty regarding changes in poleward energy transport in midlatitudes in G1, as well as for changes in cross-equatorial energy transport, which are anticorrelated with ITCZ shifts.

  5. Identification of G1-regulated genes in normally cycling human cells.

    Directory of Open Access Journals (Sweden)

    Maroun J Beyrouthy

    Full Text Available BACKGROUND: Obtaining synchronous cell populations is essential for cell-cycle studies. Methods such as serum withdrawal or use of drugs which block cells at specific points in the cell cycle alter cellular events upon re-entry into the cell cycle. Regulatory events occurring in early G1 phase of a new cell cycle could have been overlooked. METHODOLOGY AND FINDINGS: We used a robotic mitotic shake-off apparatus to select cells in late mitosis for genome-wide gene expression studies. Two separate microarray experiments were conducted, one which involved isolation of RNA hourly for several hours from synchronous cell populations, and one experiment which examined gene activity every 15 minutes from late telophase of mitosis into G1 phase. To verify synchrony of the cell populations under study, we utilized methods including BrdU uptake, FACS, and microarray analyses of histone gene activity. We also examined stress response gene activity. Our analysis enabled identification of 200 early G1-regulated genes, many of which currently have unknown functions. We also confirmed the expression of a set of genes candidates (fos, atf3 and tceb by qPCR to further validate the newly identified genes. CONCLUSION AND SIGNIFICANCE: Genome-scale expression analyses of the first two hours of G1 in naturally cycling cells enabled the discovery of a unique set of G1-regulated genes, many of which currently have unknown functions, in cells progressing normally through the cell division cycle. This group of genes may contain future targets for drug development and treatment of human disease.

  6. Puppet Visual Adaptation on Playing Cards as Educational Media

    Directory of Open Access Journals (Sweden)

    Joko Wiyoso

    2017-02-01

    Full Text Available This study aims at presenting an effective media in a form of puppet picture playing cards as a means to introduce traditional puppet to the society. Research and Development (R&D was chosen as the method to develop the playing cards. Results were presented in a form of the design of puppet picture playing cards as many as 54 cards as well as 54 puppet characters as the background pictures. The design of the playing cards is adjusted to the common playing cards which are distributed widely in the society, including both the sizes and symbols, like the pictures of spade, heart, diamond, and club. In detail, the design comprises: (1 the size of playing cards which is 6 cm width of the upper and lower sides and 9 cm length for the left and right sides. (2 The playing cards’ background is in a bright color so does the puppet picture on the card can be seen clearly.

  7. Credit and Debit Card Usage and Cash Flow Management Control ...

    African Journals Online (AJOL)

    : Evidences from Commercial Banks Customers in Kisumu City, Kenya. ... Abstract. In the recent past, the banking sector in Kenya has witnessed a rapid growth, issuing thousands of credit cards and millions of debit cards to their customers.

  8. Barber's Point, Oahu, Hawaii Drift Card Study 2002-2004

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Drift cards were be released from Barber's Point, Oahu, approximately once a month during the two year span to get an idea of the distribution of card drift under...

  9. RENEWAL OF CRIMINAL LAW AGAINST ABUSE OF CREDIT CARDS

    Directory of Open Access Journals (Sweden)

    Eka Nugraha

    2015-07-01

    Full Text Available The use of credit cards for payment in lieu of cash since the introduction of the first credit card ever more widely known and used by people.   On the early introduction of this credit card, the wearer is limited to certain circles. However, a few decades later the credit card industry primarily enter the end of the Decade of the 1970s, has penetrated almost throughout all parts of the world, including Indonesia.   A credit card is issued by most commonly used by the public and apply the current International consists of a range of brands, among others, a very popular one is Visa and Master Card are each issued by the credit card company international and Master Card International.In practice many found the works in banking that may be subject to sanctions as set forth in the book of the law of criminal law (Criminal Code.

  10. Evaluation Of The I-110 Corridor Smart Card Demonstration Project

    OpenAIRE

    Giulian, Genevieve; Moore, II, James E.

    1996-01-01

    This report presents an evaluation of the Phase II Smart Card Demonstration Project, the goal of which is to develop a transit fare payment system for commercialization that will improve transit efficiency and effectiveness. The major focus of the project is the testing of selected technologies in revenue service. Two types of fare payment cards were selected: a contactless radio frequency (RF) card and a contact card. The advanced fare payment system includes passenger transaction units inst...

  11. Clinicians completion rate of radiology request card in a Nigerian ...

    African Journals Online (AJOL)

    The importance of adequately completing the radiology request card by the clinicians, in management of patient cannot be overemphasized. Omission of information on the request card may lead to reporting error. This study investigated the compliance rate of filling the radiology request card by clinicians received in a ...

  12. Using a Card Trick to Illustrate Fixed Points and Stability

    Science.gov (United States)

    Champanerkar, Jyoti; Jani, Mahendra

    2015-01-01

    Mathematical ideas from number theory, group theory, dynamical systems, and computer science have often been used to explain card tricks. Conversely, playing cards have been often used to illustrate the mathematical concepts of probability distributions and group theory. In this paper, we describe how the 21-card trick may be used to illustrate…

  13. Consumers' use of and satisfaction with store cards

    African Journals Online (AJOL)

    Administrator

    the interest of informed, responsible consumer behav- iour, consumers' use of store cards and their manage- ment of credit .... Stores cards are issued to consumers across the socio economic spectrum. Consumers in lower ...... Smart cards and retailers - who stand to benefit? International Journal of Retail and Distribution ...

  14. 76 FR 76475 - Employment Network (EN) Report Card

    Science.gov (United States)

    2011-12-07

    ... ADMINISTRATION Employment Network (EN) Report Card AGENCY: Social Security Administration. ACTION: Notice of... Public Comments on Draft Revised Ticket to Work Consumer Employment Network Report Card. SUMMARY: We are..., and the general public on the draft revised EN Report Card. An EN is a private or public entity that...

  15. Fingerprint match-on-card: review and outlook

    CSIR Research Space (South Africa)

    Shabalala, MB

    2015-03-01

    Full Text Available available inside a smart card. The pre-calculation of data outside the smart card compromises the security offered by the card and the look-up table limits the accuracy of the biometric comparison. The paper reviews the techniques and challenges...

  16. 22 CFR 50.9 - Card of identity.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Card of identity. 50.9 Section 50.9 Foreign... of United States Nationality of a Person Abroad § 50.9 Card of identity. When authorized by the Department, consular offices or designated nationality examiners may issue a card of identity for travel to...

  17. Cool Moves: Teaching Geography and History with HyperCard.

    Science.gov (United States)

    Adams, Richard C.

    1995-01-01

    Discusses a project developed using HyperCard to teach geography and history. Describes research of weather patterns and corresponding historical accounts; HyperCard's capabilities for producing animated maps to display information; and the effectiveness of HyperCard as a teaching tool, including its flexible use as a lecture display tool or in a…

  18. Credit and Debit Card Usage and Cash Flow Management Control ...

    African Journals Online (AJOL)

    First Lady

    2012-10-27

    Oct 27, 2012 ... Control by Customers: Evidences from Commercial Banks. Customers in Kisumu City, Kenya ... Key words: Debit cards, credit cards, commercial banks, Kenya. Introduction. The development of credit card is ..... has an effect of leading to cash deficits on the side of cardholders. The results also indicate an ...

  19. 77 FR 75410 - Request for Information Regarding Credit Card Market

    Science.gov (United States)

    2012-12-20

    ... PROTECTION Request for Information Regarding Credit Card Market AGENCY: Bureau of Consumer Financial... Financial Protection (Bureau) to conduct a review (Review) of the consumer credit card market, within the... the public about a number of aspects of the consumer credit card market, which are described further...

  20. Info card for surgery waiting room improves satisfaction.

    Science.gov (United States)

    2015-11-01

    A hospital is reporting improved patient satisfaction from providing an information card in the surgery department. The card includes expected wait times. The card is provided by the patient transport team. Telephone numbers are included for more information. Staff update family members hourly during surgery.

  1. Credit and Debit Card Usage and Cash Flow Management Control ...

    African Journals Online (AJOL)

    In the recent past, the banking sector in Kenya has witnessed a rapid growth, issuing thousands of credit cards and millions of debit cards to their customers. The frequency in which customers use these cards for various transactions raised concerns of whether customers had lost control over their finances. Previous studies ...

  2. On Cyclic Plans for Scheduling a Smart Card Personalisation System

    NARCIS (Netherlands)

    Nieberg, T.

    An industrial case study for scheduling the personalisation of smart cards is presented and analysed. Smart cards are personalised in several machines that are served by an underlying conveyor belt connecting these. As there are usually a very high number of smart cards to be personalised, the focus

  3. 25 CFR 11.422 - Unauthorized use of credit cards.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Unauthorized use of credit cards. 11.422 Section 11.422... LAW AND ORDER CODE Criminal Offenses § 11.422 Unauthorized use of credit cards. (a) A person commits a misdemeanor if he or she uses a credit card for the purpose of obtaining property or services with knowledge...

  4. Credit Card Attitudes and Behaviors of College Students

    Science.gov (United States)

    Joo, S.-H.; Grable, J. E.; Bagwell, D. C.

    2005-01-01

    At a southwestern public university, 242 students responded to a questionnaire about their credit-card use and attitudes. The results revealed that about 70 percent of the students held one or more credit cards, and about 10 percent had five or more credit cards. Twenty-two percent never kept copies of their charge slips, and only 49 percent paid…

  5. CARISPLAN Procedure Manual: Institutional Author Record Card.

    Science.gov (United States)

    United Nations Economic Commission for Latin America, Port-of-Spain (Trinadad). Caribbean Documentation Centre.

    This manual outlines the prescribed format and content of an institutional author record card, which forms the basis of the CARISPLAN (Caribbean Information System for Economic and Social Planning) Institutional Author Authority File used in conjunction with the databases of the United Nations (UN) Economic Commission for Latin America (ECLA).…

  6. Artist Trading Cards: Connecting with Other Communities

    Science.gov (United States)

    Bovio, Deborah

    2011-01-01

    Creating and exchanging Artist Trading Cards (ATCs) has been a rapidly growing trend. These miniature works of art are fun to make--and even more fun to share. The intrigue of developing these handmade treasures begins with the intent of creating art simply for the love of art. In this article, the author describes how her students made their…

  7. From Cards to Online: The Asian Connection.

    Science.gov (United States)

    Rogers, Gloria H.

    1986-01-01

    Description of the conversion of San Diego State University Library's Asian collection from catalog cards to online catalog through OCLC discusses technical problems involved in creating databases with Chinese, Japanese, and Korean vernacular characters. Ambiguities created by romanization and decision to convert the collection only in romanized…

  8. Integration through a Card-Sort Activity

    Science.gov (United States)

    Green, Kris; Ricca, Bernard P.

    2015-01-01

    Learning to compute integrals via the various techniques of integration (e.g., integration by parts, partial fractions, etc.) is difficult for many students. Here, we look at how students in a college level Calculus II course develop the ability to categorize integrals and the difficulties they encounter using a card sort-resort activity. Analysis…

  9. CARD15 gene mutations in periodontitis

    NARCIS (Netherlands)

    Laine, ML; Murillo, LS; Morre, SA; Winkel, EG; Pena, AS; van Winkelhoff, AJ

    2004-01-01

    Objectives: The CARD15 gene encodes the Nod2 protein, which is involved in intracellular recognition of bacterial products like peptidoglycan, activates inflammation and regulates apoptosis through nuclear factor-kappa B, a transcription factor that plays a central role in the innate immunity. Two

  10. Fingerprint matching on smart card: A review

    CSIR Research Space (South Africa)

    Baruni, Kedimotse P

    2016-12-01

    Full Text Available the biometric matching takes place. However, it is challenging to implement an accurate fingerprint MoC algorithm, which can execute in a short period of time due the limited working memory and processing speed that the smart card provides. Implementing a...

  11. Optical security features for plastic card documents

    Science.gov (United States)

    Hossick Schott, Joachim

    1998-04-01

    Print-on-demand is currently a major trend in the production of paper based documents. This fully digital production philosophy will likely have ramifications also for the secure identification document market. Here, plastic cards increasingly replace traditionally paper based security sensitive documents such as drivers licenses and passports. The information content of plastic cards can be made highly secure by using chip cards. However, printed and other optical security features will continue to play an important role, both for machine readable and visual inspection. Therefore, on-demand high resolution print technologies, laser engraving, luminescent pigments and laminated features such as holograms, kinegrams or phase gratings will have to be considered for the production of secure identification documents. Very important are also basic optical, surface and material durability properties of the laminates as well as the strength and nature of the adhesion between the layers. This presentation will address some of the specific problems encountered when optical security features such as high resolution printing and laser engraving are to be integrated in the on-demand production of secure plastic card identification documents.

  12. Insuficiencia cardíaca y diabetes

    Directory of Open Access Journals (Sweden)

    Jorge Thierer

    2006-01-01

    Full Text Available La prevalencia de la insuficiencia cardíaca y la diabetes continúa creciendo. Ambas están fuertemente asociadas. La diabetes es un fuerte predictor de aparición de insuficiencia cardíaca. Las razones son la presencia de enfermedad coronaria y los trastornos metabólicos vinculados con la resistencia a la insulina que generan disfunción contráctil. Los pacientes con insuficiencia cardíaca que son diabéticos tienen peor evolución. Los Betabloqueantes, vasodilatadores y los inhibidores de la enzima convertidora ejercen una influencia favorable, en tanto que el uso de glitazonas todavía es controversial. La insuficiencia cardíaca puede a su vez generar diabetes, debido a la activación del sistema nervioso simpático y al efecto del tratamiento. La comprensión adecuada de estos hechos es fundamental para tomar decisiones correctas y mejorar la suerte de los pacientes.

  13. Dealing with Student Credit Card Debt.

    Science.gov (United States)

    Stanford, William E.

    1999-01-01

    Discusses the danger of college students accumulating a level of credit card debt that can seriously undermine their future lives. Offers 10 suggestions for colleges including controlling solicitations, offering workshops to freshmen, adding credit information to the campus Web site, communicating with the senior class, and discouraging or…

  14. Looking at Debit and Credit Card Fraud

    Science.gov (United States)

    Porkess, Roger; Mason, Stephen

    2012-01-01

    This article, written jointly by a mathematician and a barrister, looks at some of the statistical issues raised by court cases based on fraud involving chip and PIN cards. It provides examples and insights that statistics teachers should find helpful. (Contains 4 tables and 1 figure.)

  15. The Eggen Card Project (Poster abstract)

    Science.gov (United States)

    Silvis, G.

    2015-06-01

    (Abstract only) At the 2013 meeting we kicked off the Eggen Card project. This project was to make the huge collection of photometric observations made by Olin Eggen accessible to researchers. My poster this year is to report progress and encourage more members to participate.

  16. Lagrangian Submesoscale Experiment (LASER) drift cards

    DEFF Research Database (Denmark)

    Carlson, Daniel Frazier

    2017-01-01

    of imagery to study near-surface transport and dispersion. A GPS and inertial navigation system (INS) were also installed on STARRS. However, initialization issues with the INS resulted in inaccurate heading data for most of the drift card experiments. The GPS-INS data are also not precisely synchronized...

  17. Resistin causes G1 arrest in colon cancer cells through upregulation of SOCS3.

    Science.gov (United States)

    Singh, Snahlata; Chouhan, Surbhi; Mohammad, Naoshad; Bhat, Manoj Kumar

    2017-05-01

    Resistin, a proinflammatory cytokine, is elevated in a number of pathological disorders, including cancer. The serum resistin level in colon cancer patients is elevated and correlates with tumor grade. However, the implications of increased resistin on colon cancer cells remain unclear. In the present study, we find that resistin binds to TLR4 on colon cancer cell membrane and initiates TLR4-MyD88-dependent activation of ERK. In addition, the upregulation of SOCS3 by ERK downregulates the JAK2/TAT3 pathway and causes the arrest of cells in G1 phase. Interestingly, we observe that resistin-exposed cells survive 5-fluorouracil treatment because of a decrease in drug uptake due to the arrest of cells in G1 phase. © 2017 Federation of European Biochemical Societies.

  18. Probabilistic Decomposition Method on the ServerIndices of an Mξ/G/1 Vacation Queue

    Directory of Open Access Journals (Sweden)

    Renbin Liu

    2014-01-01

    Full Text Available This paper develops a probabilistic decomposition method for an Mξ/G/1 repairable queueing system with multiple vacations, in which the customers who arrive during server vacations enter the system with probability p. Such a novel method is used to analyze the main performance indices of the server, such as the unavailability and the mean failure number during (0,t]. It is derived that the structures of server indices are two convolution equations. Further, comparisons with existing methods indicate that our method is effective and applicable for studying server performances in single-server Mξ/G/1 vacation queues and their complex variants. Finally, a stochastic order and production system with a multipurpose production facility is numerically presented for illustrative purpose.

  19. PIQA: pipeline for Illumina G1 genome analyzer data quality assessment.

    Science.gov (United States)

    Martínez-Alcántara, A; Ballesteros, E; Feng, C; Rojas, M; Koshinsky, H; Fofanov, V Y; Havlak, P; Fofanov, Y

    2009-09-15

    PIQA is a quality analysis pipeline designed to examine genomic reads produced by Next Generation Sequencing technology (Illumina G1 Genome Analyzer). A short statistical summary, as well as tile-by-tile and cycle-by-cycle graphical representation of clusters density, quality scores and nucleotide frequencies allow easy identification of various technical problems including defective tiles, mistakes in sample/library preparations and abnormalities in the frequencies of appearance of sequenced genomic reads. PIQA is written in the R statistical programming language and is compatible with bustard, fastq and scarf Illumina G1 Genome Analyzer data formats. The PIQA pipeline, installation instructions and examples are available at the supplementary web site (http://bioinfo.uh.edu/PIQA).

  20. Non-thermal properties of SNR G1.9+0.3

    Science.gov (United States)

    Ksenofontov, Leonid; Voelk, Heinrich; Berezhko, Evgeny

    The properties of the -presumably -youngest Galactic supernova remnant (SNR) G1.9+0.3 are investigated within the framework of nonlinear kinetic theory of cosmic ray acceleration in SNRs. The observed angular size and expansion speed as well as the radio and X-ray emission measurements are used to determine relevant physical parameters of this SNR. Under the assumption that SNR G1.9+0.3 is the result of a Type Ia supernova near the Galactic center (at the distance d=8.5 kpc) the nonthermal properties are calculated. In particular, the expected TeV-gamma ray spectral energy density is predicted to be as low as γ Fγ ≈ 5 × 10-15 erg cm-2 s-1 , strongly dependent (Fγ ∝ d-11 ) upon the source distance d.

  1. Nonthermal Properties of Supernova Remnant G1.9+0.3

    Science.gov (United States)

    Ksenofontov, L. T.; Völk, H. J.; Berezhko, E. G.

    2010-05-01

    The properties of the—presumably—youngest Galactic supernova remnant (SNR) G1.9+0.3 are investigated within the framework of nonlinear kinetic theory of cosmic ray acceleration in SNRs. The observed angular size and expansion speed as well as the radio and X-ray emission measurements are used to determine relevant physical parameters of this SNR. Under the assumption that SNR G1.9+0.3 is the result of a Type Ia supernova near the Galactic center (at the distance d = 8.5 kpc), the nonthermal properties are calculated. In particular, the expected TeV gamma-ray spectral energy density is predicted to be as low as epsilonγ F γ ≈ 5 × 10-15 erg cm-2 s-1, strongly dependent (F γ vprop d -11) upon the source distance d.

  2. Permanent draft genome sequence of the gliding predator Saprospira grandis strain Sa g1 (= HR1).

    Science.gov (United States)

    Mavromatis, Konstantinos; Chertkov, Olga; Lapidus, Alla; Nolan, Matt; Lucas, Susan; Tice, Hope; Del Rio, Tijana Glavina; Cheng, Jan-Fang; Han, Cliff; Tapia, Roxanne; Bruce, David; Goodwin, Lynne A; Pitluck, Sam; Huntemann, Marcel; Liolios, Konstantinos; Pagani, Ioanna; Ivanova, Natalia; Mikhailova, Natalia; Pati, Amrita; Chen, Amy; Palaniappan, Krishna; Land, Miriam; Brambilla, Evelyne-Marie; Rohde, Manfred; Spring, Stefan; Göker, Markus; Detter, John C; Bristow, James; Eisen, Jonathan A; Markowitz, Victor; Hugenholtz, Philip; Kyrpides, Nikos C; Klenk, Hans-Peter; Woyke, Tanja

    2012-05-25

    Saprospira grandis Gross 1911 is a member of the Saprospiraceae, a family in the class 'Sphingobacteria' that remains poorly characterized at the genomic level. The species is known for preying on other marine bacteria via 'ixotrophy'. S. grandis strain Sa g1 was isolated from decaying crab carapace in France and was selected for genome sequencing because of its isolated location in the tree of life. Only one type strain genome has been published so far from the Saprospiraceae, while the sequence of strain Sa g1 represents the second genome to be published from a non-type strain of S. grandis. Here we describe the features of this organism, together with the complete genome sequence and annotation. The 4,495,250 bp long Improved-High-Quality draft of the genome with its 3,536 protein-coding and 62 RNA genes is a part of the Genomic Encyclopedia of Bacteria and Archaea project.

  3. Rare Coumarins Induce Apoptosis, G1 Cell Block and Reduce RNA Content in HL60 Cells

    Directory of Open Access Journals (Sweden)

    Widelski Jarosław

    2017-02-01

    Full Text Available The rare coumarins stenocarpin, stenocarpin isobutyrate, oficinalin, oficinalin isobutyrate, 8-methoxypeucedanin and the known xanthotoxin, isoimperatorin, bergapten, peucedanin and 8–methoxyisoimperatorin were isolated from Peucedanum luxurians Tamamsch. (Apiaceae and identified by means of spectral data (1D and 2D NMR. Their immunomodulating activity was evaluated by flow cytometry and their influence on HL60 cells as well as on PHA-stimulated PBLs was tested. All tested coumarins induce apoptosis (maximal in the 48 h culture and decrease cell proliferation in a time- and dose-dependent manner, especially in HL60 cells. They also induce partial G1 block, but only in HL60 cells (at 100 µM concentrations. Dose-dependent reduction of RNA content was also found in G1 cells treated by the coumarins. All of the tested coumarins also possessed immunomodulatory activities. Bergapten and xanthotoxin were found to be the best candidates for further evaluation as anti-cancer drugs.

  4. The MAP, M/G1,G2/1 queue with preemptive priority

    Directory of Open Access Journals (Sweden)

    Bong Dae Choi

    1997-01-01

    Full Text Available We consider the MAP, M/G1,G2/1 queue with preemptive resume priority, where low priority customers arrive to the system according to a Markovian arrival process (MAP and high priority customers according to a Poisson process. The service time density function of low (respectively: high priority customers is g1(x (respectively: g2(x. We use the supplementary variable method with Extended Laplace Transforms to obtain the joint transform of the number of customers in each priority queue, as well as the remaining service time for the customer in service in the steady state. We also derive the probability generating function for the number of customers of low (respectively, high priority in the system just after the service completion epochs for customers of low (respectively, high priority.

  5. On the Discrete-Time Geo/G/1 Queue with Vacations in Random Environment

    Directory of Open Access Journals (Sweden)

    Jianjun Li

    2016-01-01

    Full Text Available A discrete-time Geo/G/1 queue with vacations in random environment is analyzed. Using the method of supplementary variable, we give the probability generating function (PGF of the stationary queue length distribution at arbitrary epoch. The PGF of the stationary sojourn time distribution is also derived. And we present the various performance measures such as mean number of customers in the system, mean length of the type-i cycle, and mean time that the system resides in phase 0. In addition, we show that the M/G/1 queue with vacations in random environment can be approximated by its discrete-time counterpart. Finally, we present some special cases of the model and numerical examples.

  6. Digitizing Villanova University's Eclipsing Binary Card Catalogue

    Science.gov (United States)

    Guzman, Giannina; Dalton, Briana; Conroy, Kyle; Prsa, Andrej

    2018-01-01

    Villanova University’s Department of Astrophysics and Planetary Science has years of hand-written archival data on Eclipsing Binaries at its disposal. This card catalog began at Princeton in the 1930’s with notable contributions from scientists such as Henry Norris Russel. During World War II, the archive was moved to the University of Pennsylvania, which was one of the world centers for Eclipsing Binary research, consequently, the contributions to the catalog during this time were immense. It was then moved to University of Florida at Gainesville before being accepted by Villanova in the 1990’s. The catalog has been kept in storage since then. The objective of this project is to digitize this archive and create a fully functional online catalog that contains the information available on the cards, along with the scan of the actual cards. Our group has built a database using a python-powered infrastructure to contain the collected data. The team also built a prototype web-based searchable interface as a front-end to the catalog. Following the data-entry process, information like the Right Ascension and Declination will be run against SIMBAD and any differences between values will be noted as part of the catalog. Information published online from the card catalog and even discrepancies in information for a star, could be a catalyst for new studies on these Eclipsing Binaries. Once completed, the database-driven interface will be made available to astronomers worldwide. The group will also acquire, from the database, a list of referenced articles that have yet to be found online in order to further pursue their digitization. This list will be comprised of references in the cards that were neither found on ADS nor online during the data-entry process. Pursuing the integration of these references to online queries such as ADS will be an ongoing process that will contribute and further facilitate studies on Eclipsing Binaries.

  7. The MX/G/1 queue with queue length dependent service times

    Directory of Open Access Journals (Sweden)

    Bong Dae Choi

    2001-01-01

    Full Text Available We deal with the MX/G/1 queue where service times depend on the queue length at the service initiation. By using Markov renewal theory, we derive the queue length distribution at departure epochs. We also obtain the transient queue length distribution at time t and its limiting distribution and the virtual waiting time distribution. The numerical results for transient mean queue length and queue length distributions are given.

  8. M/G/1 Subject to an Initial Quorum of Customers.

    Science.gov (United States)

    1986-11-01

    size" for : i M/G/1(m). (Note: In that prior report m stands for the current m+1. The change simplifies somewhat the typography of many formulas.) We...2*A+x)+ 4)(A+2 x)+ 4(3*x)a + p (w.) ". where w. is the delay conditioned upon the server working. We simplify the typography of (1.4) and (1.4) by

  9. Modelling M/G/1 queueing systems with server vacations using ...

    African Journals Online (AJOL)

    Figure 2: MRSPN model of the single vacation M/G/1/N/Vl queueing system. There is an additional place PC in this model to record the fact that the server has com- pleted at least one service before going away on a vacation. The immediate transition S2, when enabled, places a token in PC, thus keeping a record of the first ...

  10. Long-Term Monitoring of 'Active Asteroid' P/2016 G1 (PANSTARRS)

    Science.gov (United States)

    Milewski, Dave Gerald; Jewitt, David; Rich, Robert Michael

    2017-10-01

    We present updated results of repeated monitoring of ‘Active Asteroid’ P/2016 G1 (PANSTARRS) using the 0.7-m, f/3.2 Jeanne Rich Telescope at the Jay Baum Rich Observatory in Frazier Park, CA, as well as the Keck 10-m telescope equipped with the LRIS instrument. The ‘Active Asteroids’ are a strange and newly discovered class of small bodies in the Solar System that have the orbital and dynamical properties of asteroids and also the physical properties of comets; for example, ejection of dust and volatile materials. P/2016 G1 (PANSTARRS) was detected in 2016 April by R. Weryk and R. Wainscoat using the 1.8-m PANSTARRS1 telescope and appears to exhibit activity potentially due to catastrophic impact of the main body (Moreno et al. 2016). In this work, we have monitored P/2016 G1 (PANSTARRS) from the months of April to August 2016 to better understand the mechanism and drivers of activity in this Solar System small body and detect changes in the appearance form which to form a more complete picture of this object.

  11. Optimized culture condition for enhancing lytic performance of waste activated sludge by Geobacillus sp. G1.

    Science.gov (United States)

    Yang, Chunxue; Zhou, Aijuan; Hou, Yanan; Zhang, Xu; Guo, Zechong; Wang, Aijie; Liu, Wenzong

    2014-01-01

    Hydrolysis is known as the rate-limiting step during waste activated sludge (WAS) digestion. The optimization of the culture conditions of Geobacillus sp. G1 for enhancing WAS hydrolysis was conducted in this study with uniform design and response surface methodology. Taking the lysis rate of Escherichia coli as the response, the Plackett-Burman design was used to screen the most important variables. Experimental results showed that the maximum predicted lysis rate of E. coli was 50.9% for 4 h treatment time with concentrations of skim milk, NaCl and NH4SO4 at 10.78, 4.36 and 11.28 g/L, respectively. The optimized dosage ratio of Geobacillus sp. G1 to WAS was 35%:65% (VG1:VWAS). Under this condition, soluble protein was increased to 695 mg chemical oxygen demand (COD)/L, which was 5.0 times higher than that obtained in the control (140 mg COD/L). The corresponding protease activity reached 1.1 Eu/mL. Scanning electron microscopy showed that abundant cells were apparently lysed with treatment of Geobacillus sp. G1.

  12. Clinical reactivity of celery cultivars in allergic patients: Role of Api g 1.

    Science.gov (United States)

    Dölle, S; Welter, S; Ruppel, E; Lehmann, K; Schwarz, D; Jensen-Jarolim, E; Zieglmayer, P; Franken, P; Worm, M

    2018-01-25

    Celery (Apium graveolens L.) is a vegetable consumed world-wide. Celery stalks and celeriac roots are often ingredients in convenient food products like spice blends and soups. In this study, we examined the allergenicity of distinct celeriac cultivars. Sixteen celery-allergic patients were identified using a double-blind, placebo-controlled food challenge. Ten different celeriac cultivars were used for skin prick testing in the patients. Two cultivars were further applied for oral food challenges; their protein composition was analysed by immunoblotting, and contents of major allergen Api g 1 were quantified. From the 10 investigated celeriac cultivars, two cultivars elicited significantly different skin reactivity ("Anita": 5.0 [2.0-12.0] mm vs "Prinz": 7.0 [3.0-9.5] mm; P = .047). Moreover, "Anita" induced fewer symptoms after a controlled oral-celeriac challenge in 14 patient (P Api g 1 in "Prinz" than in "Anita." Taken together, the data from this study suggest that cultivar Anita is better tolerated in celery-allergic patients than "Prinz." Differences in the protein expression profile between the cultivars, particularly the different content of Api g 1, could cause the different allergenicity. © 2018 John Wiley & Sons Ltd.

  13. Developing Usage Guidelines for a Card-Based Design Tool : A Case of the Positive Emotional Granularity Cards

    NARCIS (Netherlands)

    Yoon, J; Desmet, P.M.A.; Pohlmeyer, A.E.

    2016-01-01

    Background Card-based design tools have gained popularity as a means to communicate
    research insights and to make them usable in a design process. There are various examples of card
    tools and guidelines for developing a card set itself, yet there has been little research into how

  14. The possibility of using "Job Card" for career education

    OpenAIRE

    横山, 裕; ヨコヤマ, ユタカ; Yutaka, YOKOYAMA

    2009-01-01

    This paper described the advantage of using a "job card" for career education. "The job card system" is a new system that began this year. The original purpose of "the job card system" is to support a person looking for a job. When a job seeker writes a "job card", the job seeker can understand his own work experience and employment possibilities while getting the advice of the career counselor. If a teacher utilized a "job card" for career education in this way, the student can understand hi...

  15. Consumer Credit Card Use Intention and Influence Factors Analysis

    Directory of Open Access Journals (Sweden)

    Wang Yantao

    2017-01-01

    Full Text Available Credit card as a kind of advanced means of payment and the new way of consumer credit in the world widely, but in our country is faced with some problems, such as their per capita spending is low, open the card number is small, motionless bank card is a lot. In this paper, using the Logit model to analyze the Anshan city in Liaoning province consumer credit card usage. And combined with empirical analysis to provide banking management Suggestions and marketing countermeasures, including targeted to provide different kinds of credit card.

  16. The H,G_1,G_2 photometric system with scarce observational data

    Science.gov (United States)

    Penttilä, A.; Granvik, M.; Muinonen, K.; Wilkman, O.

    2014-07-01

    The H,G_1,G_2 photometric system was officially adopted at the IAU General Assembly in Beijing, 2012. The system replaced the H,G system from 1985. The 'photometric system' is a parametrized model V(α; params) for the magnitude-phase relation of small Solar System bodies, and the main purpose is to predict the magnitude at backscattering, H := V(0°), i.e., the (absolute) magnitude of the object. The original H,G system was designed using the best available data in 1985, but since then new observations have been made showing certain features, especially near backscattering, to which the H,G function has troubles adjusting to. The H,G_1,G_2 system was developed especially to address these issues [1]. With a sufficient number of high-accuracy observations and with a wide phase-angle coverage, the H,G_1,G_2 system performs well. However, with scarce low-accuracy data the system has troubles producing a reliable fit, as would any other three-parameter nonlinear function. Therefore, simultaneously with the H,G_1,G_2 system, a two-parameter version of the model, the H,G_{12} system, was introduced [1]. The two-parameter version ties the parameters G_1,G_2 into a single parameter G_{12} by a linear relation, and still uses the H,G_1,G_2 system in the background. This version dramatically improves the possibility to receive a reliable phase-curve fit to scarce data. The amount of observed small bodies is increasing all the time, and so is the need to produce estimates for the absolute magnitude/diameter/albedo and other size/composition related parameters. The lack of small-phase-angle observations is especially topical for near-Earth objects (NEOs). With these, even the two- parameter version faces problems. The previous procedure with the H,G system in such circumstances has been that the G-parameter has been fixed to some constant value, thus only fitting a single-parameter function. In conclusion, there is a definitive need for a reliable procedure to produce

  17. Stabilization of IgG1 in spray-dried powders for inhalation.

    Science.gov (United States)

    Schüle, S; Schulz-Fademrecht, T; Garidel, P; Bechtold-Peters, K; Frieb, W

    2008-08-01

    The protein stabilizing capabilities of spray-dried IgG1/mannitol formulations were evaluated. The storage stability was tested at different residual moisture levels prepared by vacuum-drying or equilibration prior to storage. Vacuum-drying at 32 degrees C/0.1mbar for 24h reduced the moisture level below 1%, constituting an optimal basis for improved storage stability. The crystalline IgG1/mannitol powders with a weight ratio of 20/80 up to 40/60 failed to prevent the antibody aggregation as assessed by size exclusion chromatography during storage. Ratios of 60/40 up to 80/20 IgG1/mannitol provided superior stability of the antibody and the powders could be produced with high yields. The lower the residual moisture, the better was the stabilizing capability. An amount of 20% mannitol provided the best stabilization. Storage stability of 60/40, 70/30, and 80/20 IgG1/mannitol formulations over one year was adequate at 2-8 degrees C and 25 degrees C. Closed storage (sealed in vials) at 40 degrees C/75% RH and open storage at 25 degrees C/60% RH revealed that the stability still required optimization. The lower the protein content, the better was the powder flowability. The aerodynamic properties of powders spray-dried with 10% solids content were inadequate, as the particle size ranged between 5.1 and 7.2 microm and the fine particle fraction accounted for only 4-11%. Reduction of the solids content to 2.5% did improve the aerodynamic properties as the mass mean aerodynamic diameter was reduced to 3.6 microm and the fine particle fraction was increased to about 14%. The reduction of the solids content did not influence the storage stability significantly. Also spray-drying at higher temperatures had no significant impact on the storage stability, despite a higher tendency to form amorphous systems. In order to improve the storage stability and to maintain the good flowability of 70/30 IgG1/mannitol powder or to keep the storage stability but to improve the flowability

  18. The G1 restriction point as critical regulator of neocortical neuronogenesis

    Science.gov (United States)

    Caviness, V. S. Jr; Takahashi, T.; Nowakowski, R. S.

    1999-01-01

    Neuronogenesis in the pseudostratified ventricular epithelium is the initial process in a succession of histogenetic events which give rise to the laminate neocortex. Here we review experimental findings in mouse which support the thesis that the restriction point of the G1 phase of the cell cycle is the critical point of regulation of the overall neuronogenetic process. The neuronogenetic interval in mouse spans 6 days. In the course of these 6 days the founder population and its progeny execute 11 cell cycles. With each successive cycle there is an increase in the fraction of postmitotic cells which leaves the cycle (the Q fraction) and also an increase in the length of the cell cycle due to an increase in the length of the G1 phase of the cycle. Q corresponds to the probability that postmitotic cells will exit the cycle at the restriction point of the G1 phase of the cell cycle. Q increases non-linearly, but the rate of change of Q with cycle (i.e., the first derivative) over the course of the neuronogenetic interval is a constant, k, which appears to be set principally by cell internal mechanisms which are species specific. Q also seems to be modulated, but at low amplitude, by a balance of mitogenic and antimitogenic influences acting from without the cell. We suggest that intracellular signal transduction systems control a general advance of Q during development and thereby determine the general developmental plan (i.e., cell number and laminar composition) of the neocortex and that external mitogens and anti-mitogens modulate this advance regionally and temporally and thereby produce regional modifications of the general plan.

  19. Addition of calmodulin antagonists to NRK cells during G1 inhibits proliferating cell nuclear antigen expression.

    Science.gov (United States)

    López-Girona, A; Bosch, M; Bachs, O; Agell, N

    1995-07-01

    The mRNAs of most proteins involved in DNA synthesis show an S phase correlated expression when mammalian cells are stimulated to proliferate from G0. This is the case for proliferating cell nuclear antigen (PCNA), a cofactor of DNA polymerase delta that is essential for the synthesis of the leading and lagging strands of DNA. Normal rat kidney cells re-entering the cell cycle from quiescence start DNA synthesis at 12 h and reach a maximum at 20 h. The expression of PCNA parallels the synthesis of DNA. Progression through the S phase was inhibited by addition of the anticalmodulin drug W13 to the cells during G1, 5 h after activation. W13 also inhibited the increase in both PCNA protein and mRNA indicating that calmodulin regulates its expression. Using TK-ts13 cells transfected with a plasmid containing the thymidine kinase gene under the control of the human 2.8 kb PCNA promoter, we demonstrated that this promoter is not regulated by calmodulin. The half-life of PCNA mRNA during G1/S transition was not modified by the treatment with W13, indicating that the decrease in the mRNA found when calmodulin was inhibited is not due to changes in its stability. Run-on assays revealed that control cells produced predominantly complete PCNA transcripts during S phase, while short incomplete transcripts were generated in W13-treated cells at the same time. These results indicate that calmodulin participates in a more direct or indirect way during G1 in the activation of PCNA expression. From data presented here it can be suggested that calmodulin activates the release of a transcriptional block leading to an increase in the amount of PCNA during S phase.

  20. F-box protein specificity for g1 cyclins is dictated by subcellular localization.

    Directory of Open Access Journals (Sweden)

    Benjamin D Landry

    Full Text Available Levels of G1 cyclins fluctuate in response to environmental cues and couple mitotic signaling to cell cycle entry. The G1 cyclin Cln3 is a key regulator of cell size and cell cycle entry in budding yeast. Cln3 degradation is essential for proper cell cycle control; however, the mechanisms that control Cln3 degradation are largely unknown. Here we show that two SCF ubiquitin ligases, SCF(Cdc4 and SCF(Grr1, redundantly target Cln3 for degradation. While the F-box proteins (FBPs Cdc4 and Grr1 were previously thought to target non-overlapping sets of substrates, we find that Cdc4 and Grr1 each bind to all 3 G1 cyclins in cell extracts, yet only Cln3 is redundantly targeted in vivo, due in part to its nuclear localization. The related cyclin Cln2 is cytoplasmic and exclusively targeted by Grr1. However, Cdc4 can interact with Cdk-phosphorylated Cln2 and target it for degradation when cytoplasmic Cdc4 localization is forced in vivo. These findings suggest that Cdc4 and Grr1 may share additional redundant targets and, consistent with this possibility, grr1Δ cdc4-1 cells demonstrate a CLN3-independent synergistic growth defect. Our findings demonstrate that structurally distinct FBPs are capable of interacting with some of the same substrates; however, in vivo specificity is achieved in part by subcellular localization. Additionally, the FBPs Cdc4 and Grr1 are partially redundant for proliferation and viability, likely sharing additional redundant substrates whose degradation is important for cell cycle progression.

  1. M/G/1 vacation model with limited service discipline and hybrid switching-on policy

    Directory of Open Access Journals (Sweden)

    Alexander V. Babitsky

    1997-01-01

    Full Text Available The author studies an M/G/1 queueing system with multiple vacations. The server is turned off in accordance with the K-limited discipline, and is turned on in accordance with the T-N-hybrid policy. This is to say that the server will begin a vacation from the system if either the queue is empty or K customers were served during a busy period. The server idles until it finds at least N waiting units upon return from a vacation.

  2. Modelling M/G/1 queueing systems with server vacations using stochastic Petri nets

    Directory of Open Access Journals (Sweden)

    K Ramanath

    2006-12-01

    Full Text Available The theory of non-Markovian stochastic Petri nets is employed in this paper to derive an alternative method for studying the steady state behaviour of the M/G/1 vacation queueing system with a limited service discipline. Three types of vacation schemes are considered, and sytems with both a finite population and those with an infinite population (but finite capacity are considered. Simple numerical examples are also provided to illustrate the functionality of the methods and some useful performance measures for the system are obtained.

  3. IgG1 deficiency exacerbates experimental autoimmune myasthenia gravis in BALB/c mice

    OpenAIRE

    Huda, Ruksana; Strait, Richard T.; Tüzün, Erdem; Finkelman, Fred D.; Christadoss, Premkumar

    2015-01-01

    Myasthenia gravis is an autoimmune disease characterized by muscle weakness due to neuromuscular junction (NMJ) damage by anti-acetylcholine receptor (AChR) auto-antibodies and complement. In experimental autoimmune myasthenia gravis (EAMG), which is induced by immunization with Torpedo AChR in CFA, anti-AChR IgG2b and IgG1 are the predominant isotypes in the circulation. Complement activation by isotypes such as IgG2b plays a crucial role in EAMG pathogenesis; this suggested the possibility ...

  4. Cellular shear stiffness reflects progression of arsenic-induced transformation during G1

    DEFF Research Database (Denmark)

    Muñoz, Alexandra; Eldridge, Will J; Jakobsen, Nina Munkholt

    2017-01-01

    Cancer cells consistently exhibit decreased stiffness, however the onset and progression of this change has not been characterized. To study the development of cell stiffness changes we evaluated the shear stiffness of populations of cells during transformation to a carcinogenic state. Bronchial...... epithelial cells were exposed to sodium arsenite to initiate early stages of transformation. Exposed cells were cultured in soft agar to further transformation and select for clonal populations exhibiting anchorage independent growth. Shear stiffness of various cell populations in G1 was assessed using...

  5. Modeling and Optimization of M/G/1-Type Queueing Networks: An Efficient Sensitivity Analysis Approach

    Directory of Open Access Journals (Sweden)

    Liang Tang

    2010-01-01

    Full Text Available A mathematical model for M/G/1-type queueing networks with multiple user applications and limited resources is established. The goal is to develop a dynamic distributed algorithm for this model, which supports all data traffic as efficiently as possible and makes optimally fair decisions about how to minimize the network performance cost. An online policy gradient optimization algorithm based on a single sample path is provided to avoid suffering from a “curse of dimensionality”. The asymptotic convergence properties of this algorithm are proved. Numerical examples provide valuable insights for bridging mathematical theory with engineering practice.

  6. Properties of Multi-Stage M/G/1/K Queues with Series Arrangement

    Directory of Open Access Journals (Sweden)

    Hernández-González Salvador

    2015-07-01

    Full Text Available We propose a modification to the Buzacott & Shantikumar (1993 method to evaluate the properties of M/G/1/K queues with series arrangement. We made several tests and compared with simulation to validate the results. We observed that, with the proposed modification, the method has an acceptable level of exactitude. It can be considered an alternative calculation to other methods in the literature. The fact that this method requires less computational effort, can be useful to practitioners and managers that require tools to analyze the performance of systems in production and services areas.

  7. Optimal Policy for Mx/G/1 Queueing System with Bernoulli Feedback

    Directory of Open Access Journals (Sweden)

    Mukta Kalra

    2010-01-01

    Full Text Available We deal with Mx/G/1 Queueing System with Bernoulli feedback under N-Policy. The probability generating function and supplementary variable technique are utilized to evaluate the steady state probability distribution of the number of units in the system. The steady state results are used to establish the explicit expressions for the average number of units in the system and the mean response time for three different series time distribution. Some of the existing results are deduced as special cases. Cost analysis is performed to design the optimal N-policy at minimum cost. In order to validate the analytical approach by taking illustration we compute numerical results.

  8. Reservicing some customers in M/G/1 queues under three disciplines

    Directory of Open Access Journals (Sweden)

    M. R. Salehi-Rad

    2004-01-01

    Full Text Available Consider an M/G/1 production line in which a production item is failed with some probability and is then repaired. We consider three repair disciplines depending on whether the failed item is repaired immediately or first stockpiled and repaired after all customers in the main queue are served or the stockpile reaches a specified threshold. For each discipline, we find the probability generating function (p.g.f. of the steady-state size of the system at the moment of departure of the customer in the main queue, the mean busy period, and the probability of the idle period.

  9. Control de la estabilidad de ciclinas de G1 por nutrientes

    OpenAIRE

    Hernández Ortega, Sara

    2014-01-01

    El control del ciclo celular está altamente regulado mediante diferentes CDKs asociadas a ciclinas. En Saccharomyces cerevisiae, la CDK esencial Cdc28 es la que regula mayoritariamente este proceso. En la fase G1 del ciclo celular, otra CDK, Pho85, también colabora en este proceso asociada a las ciclinas Pcl1 y Pcl2. Pho85 se considera un enzima accesorio con funciones redundantes básicamente porqué: 1) su delección no da un fenotipo de letalidad (como si lo hace Cdc28) y 2) porqué los substr...

  10. From Secure Memories to Smart Card Security

    Science.gov (United States)

    Handschuh, Helena; Trichina, Elena

    Non-volatile memory is essential in most embedded security applications. It will store the key and other sensitive materials for cryptographic and security applications. In this chapter, first an overview is given of current flash memory architectures. Next the standard security features which form the basis of so-called secure memories are described in more detail. Smart cards are a typical embedded application that is very vulnerable to attacks and that at the same time has a high need for secure non-volatile memory. In the next part of this chapter, the secure memories of so-called flash-based high-density smart cards are described. It is followed by a detailed analysis of what the new security challenges for such objects are.

  11. Sistem Pencatatan Kehadiran Berbasis Java Card

    Directory of Open Access Journals (Sweden)

    Lidya Octarina

    2010-12-01

    Full Text Available The purposes of this research are to prevent jockey in exams, reduce the occurrence of error in attendance record at practicum or exams, and reduce error in filling students' attendance status to the attendance system. Three main parts of software development method are used; analysis, design, and literature method. Current system survey, analysis of the survey findings, identify the information, and identifying system requirements are implemented in analysis method. The design method that is used in this research is Unified Modeling Language (UML. The using of attendance recording system that uses Java Card-based application makes students identity card has a new function as the tool to make attendance. Conclusion of the research has shown that it can prevent identity fraud, minimize the time wasted in attendance system, reduce the printing paper, and reduce tagging errors eligibility status exam of students. 

  12. Dual Resolution Images from Paired Fingerprint Cards

    Science.gov (United States)

    NIST Dual Resolution Images from Paired Fingerprint Cards (Web, free access)   NIST Special Database 30 is being distributed for use in development and testing of fingerprint compression and fingerprint matching systems. The database allows the user to develop and evaluate data compression algorithms for fingerprint images scanned at both 19.7 ppmm (500 dpi) and 39.4 ppmm (1000 dpi). The data consist of 36 ten-print paired cards with both the rolled and plain images scanned at 19.7 and 39.4 pixels per mm. A newer version of the compression/decompression software on the CDROM can be found at the website http://www.nist.gov/itl/iad/ig/nigos.cfm as part of the NBIS package.

  13. SUPPORT CARD FOR THE FORWARD SCT MODULE

    CERN Document Server

    Greenall, A

    2002-01-01

    Previously in the development and testing stage of ATLAS SCT Forward modules support cards have been used which interface the module to the DAQ by using only the Redundant inputs for the module configuration and the 'spying' of the ABCD Master chip(s) data. As module development has matured there is now a necessity to be able to test modules in the laboratory using also their Primary input/output data routes i.e. using the optical chips DORIC [1] and VDC [2] but without the need of optical fibres. A Forward Kapton Support Card, FKSC, has been developed so that both Primary and Redundant data routes can be used for module testing.

  14. The topology of card transaction money flows

    Science.gov (United States)

    Zanin, Massimiliano; Papo, David; Romance, Miguel; Criado, Regino; Moral, Santiago

    2016-11-01

    Money flow models are essential tools to understand different economical phenomena, like saving propensities and wealth distributions. In spite of their importance, most of them are based on synthetic transaction networks with simple topologies, e.g. random or scale-free ones, as the characterisation of real networks is made difficult by the confidentiality and sensitivity of money transaction data. Here, we present an analysis of the topology created by real credit card transactions from one of the biggest world banks, and show how different distributions, e.g. number of transactions per card or amount, have nontrivial characteristics. We further describe a stochastic model to create transactions data sets, feeding from the obtained distributions, which will allow researchers to create more realistic money flow models.

  15. Eggen Card Project: Progress and Plans (Abstract)

    Science.gov (United States)

    Silvis, G.

    2016-12-01

    (Abstract only) The Eggen Card Project has been running since 2009 and has involved 30+ AAVSO staff and volunteers. Let me offer a short review of the project, our progress this year and our plans for the future. Phase 1 of the project has been to index the 108,000 card images, identifying the stars they belong too. We've passed the 75% point on this phase. The next phase is how to use this data. Jack Crast has identified the photometric schemes used by Olin and developed a spreadsheet tool to prepare this data for inclusion into the AAVSO International Database (AID). Anyone want good photometry from 1970? We got it!

  16. Some security strategies for smart cards

    Energy Technology Data Exchange (ETDEWEB)

    Ros, F [Gemalto, St Cyr en Val, BP 6021, 45060 Orlans Cedex (France); Harba, R [LESI, Polytech' Orlans-LESI, 12 rue de Blois, 45067 Orleans Cedex 2 (France)

    2007-07-15

    This paper details current developments at Gemalto in the field of security. It focuses on two different security processes for ID cards. The first one consists in adding observable security features in the ID image to allow quick visual verification and serves mainly to detect counterfeit attempts. The second consists in watermarking ID images during the pre personalization step by a secret key stored in the chip. The interest of the different approaches is demonstrated with several real ID images.

  17. Some security strategies for smart cards

    Science.gov (United States)

    Ros, F.; Harba, R.

    2007-07-01

    This paper details current developments at Gemalto in the field of security. It focuses on two different security processes for ID cards. The first one consists in adding observable security features in the ID image to allow quick visual verification and serves mainly to detect counterfeit attempts. The second consists in watermarking ID images during the pre personalization step by a secret key stored in the chip. The interest of the different approaches is demonstrated with several real ID images.

  18. Repeated extraction of DNA from FTA cards

    DEFF Research Database (Denmark)

    Stangegaard, Michael; Ferrero, Laura; Børsting, Claus

    2011-01-01

    Extraction of DNA using magnetic bead based techniques on automated DNA extraction instruments provides a fast, reliable and reproducible method for DNA extraction from various matrices. However, the yield of extracted DNA from FTA-cards is typically low. Here, we demonstrate that it is possible...... to repeatedly extract DNA from the processed FTA-disk. The method increases the yield from the nanogram range to the microgram range....

  19. THE CARD - CURRENCY WITH AND WITHOUT CASH

    Directory of Open Access Journals (Sweden)

    Nicoara Mihaela

    2012-12-01

    Full Text Available Use by individuals and businesses resulting in reduced cash cards in circulation, the corresponding increase in transfer payments and payments accounts also limit exchange risks and make effective use of currency. As a result, we have the effect of reducing cash in circulation. These advantages are also available for businesses and for banks and leads to favorable effects on import-export business. Following this, banks can diversify our products, so to meet customers' new products.

  20. Sarcoidosis cardíaca: trasplante cardíaco y recidiva de la enfermedad

    Directory of Open Access Journals (Sweden)

    César A. Belziti

    2010-01-01

    Full Text Available RESUMENLa sarcoidosis cardíaca es una enfermedad granulomatosa multisistémica de causa desconocida.El compromiso aislado del corazón es poco frecuente y el pronóstico se correlacionacon el grado de afectación de este órgano. El tratamiento inmunosupresor y el trasplantecardíaco han demostrado que prolongan la sobrevida; no obstante, existen comunicacionesde recidiva de la enfermedad en el órgano implantado. En esta presentación se describe uncaso de recidiva de sarcoidosis cardíaca en un paciente con miocardiopatía dilatada coninsuficiencia cardíaca avanzada, sometido a un trasplante cardíaco y en quien el diagnósticode sarcoidosis cardíaca se estableció por el estudio anatomopatológico del corazón explantado.La evolución clínica fue favorable a pesar de la recidiva de la sarcoidosis en el órgano implantado.REV ARGENT CARDIOL 2010;78:358-360.

  1. One smart card, one less car

    Energy Technology Data Exchange (ETDEWEB)

    Fenton, B.

    2003-06-30

    A system of car-sharing in Bremen, Germany, a membership-based structure of car-sharing that gives members access to a network of cars stationed throughout the city on a pay-per-trip basis, and without the hassles of car ownership, is discussed. The car-sharing scheme is combined with the city's transit system by means of a smart card that serves both as a pass for the city's transit system and as an electronic key to the cars in the car-sharing system. Future plans include to use the card also as a method of payment for taxis, and organizers are also working with the municipal government to get support for having car-sharing included in the city's official plan. At present, car-sharing stations are simply reserved parking spots for one or more cars, however, future stations are envisaged to include parking for up to five cars, a computer to book cars, direct access to keys using the smart card, parking for bicycles, and information about car-sharing stations, bus, trams, as well as bike and walking routes. Similar, if somewhat more modest, car-sharing schemes are also available in several cities in Canada, including Halifax, Quebec City, Montreal, Toronto, Calgary, Edmonton and Vancouver.

  2. Memory of Quark Matter Card Game

    CERN Document Server

    Csörgő, J; Csörgő, T

    2013-01-01

    Scientists at the Relativistic Heavy Ion Collider (RHIC, BNL) recently discovered, that the hottest known form of matter is not a gas, but acts like a fluid. Furthermore, this fluid of quarks expands and flows much more perfectly than water or any other well known fluid. This aspect of the RHIC discovery can be introduced even to primary levels of physics education, noting that the usual solid to liquid to gas sequence of phase transitions now are known to be followed by a transition to a nearly perfect fluid, a liquid of quarks, at the largest temperatures made by humans. The educational games described herein were invented by middle school students, members of a Science Club in Hungary. The games were invented for their entertainment, the educational applications in teaching high energy particle and nuclear physics to laypersons are quite unexpected but most welcomed. This manuscript describes games with a deck of cards called Quark Matter cards, where each card represents an elementary particle. The games ...

  3. LHC card games: bringing about retrocausality?

    CERN Document Server

    Silagadze, Z K

    2010-01-01

    The model of Nielsen and Ninomiya claims that "the SSC (Superconducting Supercollider) were stopped by the US Congress due to the backward causation from the big amounts of Higgs particles, which it would have produced, if it had been allowed to run". They also proposed to play a card game and if the "close LHC" card is drawn (with probability $\\sim 10^{-6}$), really close LHC on the eve of Higgs particle discovery to avoid more severe bad luck. Crazy? Probably. But paraphrasing Salvador Dali, if you believe that you and me are smarter in physics than Nielsen and Ninomiya, don't read this article, just go right on in your blissful idiocy. Therefore, I will try to make sense of backward causation. It turns out that not only the backward causation makes perfect sense in some models of possible reality, but that Nielsen and Ninomiya really have a chance to close LHC by a card game. The only thing they need is to be smart enough to manage to develop their theory up to the level of brilliance beginning from which ...

  4. Engineering upper hinge improves stability and effector function of a human IgG1.

    Science.gov (United States)

    Yan, Boxu; Boyd, Daniel; Kaschak, Timothy; Tsukuda, Joni; Shen, Amy; Lin, Yuwen; Chung, Shan; Gupta, Priyanka; Kamath, Amrita; Wong, Anne; Vernes, Jean-Michel; Meng, Gloria Y; Totpal, Klara; Schaefer, Gabriele; Jiang, Guoying; Nogal, Bartek; Emery, Craig; Vanderlaan, Martin; Carter, Paul; Harris, Reed; Amanullah, Ashraf

    2012-02-17

    Upper hinge is vulnerable to radical attacks that result in breakage of the heavy-light chain linkage and cleavage of the hinge of an IgG1. To further explore mechanisms responsible for the radical induced hinge degradation, nine mutants were designed to determine the roles that the upper hinge Asp and His play in the radical reactions. The observation that none of these substitutions could inhibit the breakage of the heavy-light chain linkage suggests that the breakage may result from electron transfer from Cys(231) directly to the heavy-light chain linkage upon radical attacks, and implies a pathway separate from His(229)-mediated hinge cleavage. On the other hand, the substitution of His(229) with Tyr showed promising advantages over the native antibody and other substitutions in improving the stability and function of the IgG1. This substitution inhibited the hinge cleavage by 98% and suggests that the redox active nature of Tyr did not enable it to replicate the ability of His to facilitate radical induced degradation. We propose that the lower redox potential of Tyr, a residue that may be the ultimate sink for oxidizing equivalents in proteins, is responsible for the inhibition. More importantly, the substitution increased the antibody's binding to FcγRIII receptors by 2-3-fold, and improved ADCC activity by 2-fold, while maintaining a similar pharmacokinetic profile with respect to the wild type. Implications of these observations for antibody engineering and development are discussed.

  5. Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair

    Directory of Open Access Journals (Sweden)

    Tony Gutschner

    2016-02-01

    Full Text Available CRISPR/Cas9 induces DNA double-strand breaks that are repaired by cell-autonomous repair pathways, namely, non-homologous end-joining (NHEJ, or homology-directed repair (HDR. While HDR is absent in G1, NHEJ is active throughout the cell cycle and, thus, is largely favored over HDR. We devised a strategy to increase HDR by directly synchronizing the expression of Cas9 with cell-cycle progression. Fusion of Cas9 to the N-terminal region of human Geminin converted this gene-editing protein into a substrate for the E3 ubiquitin ligase complex APC/Cdh1, resulting in a cell-cycle-tailored expression with low levels in G1 but high expression in S/G2/M. Importantly, Cas9-hGem(1/110 increased the rate of HDR by up to 87% compared to wild-type Cas9. Future developments may enable high-resolution expression of genome engineering proteins, which might increase HDR rates further, and may contribute to a better understanding of DNA repair pathways due to spatiotemporal control of DNA damage induction.

  6. Permanent draft genome sequence of the gliding predator Saprospira grandis strain Sa g1 (= HR1)

    Energy Technology Data Exchange (ETDEWEB)

    Mavromatis, K [U.S. Department of Energy, Joint Genome Institute; Chertkov, Olga [Los Alamos National Laboratory (LANL); Lapidus, Alla L. [U.S. Department of Energy, Joint Genome Institute; Nolan, Matt [U.S. Department of Energy, Joint Genome Institute; Lucas, Susan [U.S. Department of Energy, Joint Genome Institute; Tice, Hope [U.S. Department of Energy, Joint Genome Institute; Glavina Del Rio, Tijana [U.S. Department of Energy, Joint Genome Institute; Cheng, Jan-Fang [U.S. Department of Energy, Joint Genome Institute; Han, Cliff [Los Alamos National Laboratory (LANL); Tapia, Roxanne [Los Alamos National Laboratory (LANL); Bruce, David [Los Alamos National Laboratory (LANL); Goodwin, Lynne A. [Los Alamos National Laboratory (LANL); Pitluck, Sam [U.S. Department of Energy, Joint Genome Institute; Huntemann, Marcel [U.S. Department of Energy, Joint Genome Institute; Liolios, Konstantinos [U.S. Department of Energy, Joint Genome Institute; Pagani, Ioanna [U.S. Department of Energy, Joint Genome Institute; Ivanova, N [U.S. Department of Energy, Joint Genome Institute; Mikhailova, Natalia [U.S. Department of Energy, Joint Genome Institute; Pati, Amrita [U.S. Department of Energy, Joint Genome Institute; Chen, Amy [U.S. Department of Energy, Joint Genome Institute; Palaniappan, Krishna [U.S. Department of Energy, Joint Genome Institute; Land, Miriam L [ORNL; Brambilla, Evelyne-Marie [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Rohde, Manfred [HZI - Helmholtz Centre for Infection Research, Braunschweig, Germany; Spring, Stefan [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Goker, Markus [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Detter, J. Chris [U.S. Department of Energy, Joint Genome Institute; Bristow, James [U.S. Department of Energy, Joint Genome Institute; Eisen, Jonathan [U.S. Department of Energy, Joint Genome Institute; Markowitz, Victor [U.S. Department of Energy, Joint Genome Institute; Hugenholtz, Philip [U.S. Department of Energy, Joint Genome Institute; Kyrpides, Nikos C [U.S. Department of Energy, Joint Genome Institute; Klenk, Hans-Peter [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Woyke, Tanja [U.S. Department of Energy, Joint Genome Institute

    2012-01-01

    Saprospira grandis Gross et al. 1911 is a member of the Saprospiraceae, a family in the class 'Sphingobacteria' that remains poorly characterized at the genomic level. The species is known for preying on other marine bacteria via 'ixotrophy'. S. grandis strain Sa g1 was isolated from decaying crab carapace in France and was selected for genome sequencing because of its isolated location in the tree of life. Only one type strain genome has been published so far from the Saprospiraceae, while the sequence of strain Sa g1 represents the second genome to be published from a non-type strain of S. grandis. Here we describe the features of this organism, together with the complete genome sequence and annotation. The 4,495,250 bp long Improved-High-Quality draft of the genome with its 3,536 protein-coding and 62 RNA genes is a part of the Genomic Encyclopedia of Bacteria and Archaea project.

  7. Comparative Evaluation of the Chemical Stability of 4 Well-Defined Immunoglobulin G1-Fc Glycoforms.

    Science.gov (United States)

    Mozziconacci, Olivier; Okbazghi, Solomon; More, Apurva S; Volkin, David B; Tolbert, Thomas; Schöneich, Christian

    2016-02-01

    As part of a series of articles in this special issue evaluating model IgG1-Fc glycoforms for biosimilarity analysis, 3 well-defined IgG1-Fc glycoforms (high mannose-Fc, Man5-Fc, and N-acetylglucosamine-Fc) and a nonglycosylated Fc protein (N297Q-Fc) were examined in this work to elucidate chemical degradation pathways. The 4 proteins underwent a combination of accelerated thermal stability studies and 4 independent forced degradation studies (UV light, metal-catalyzed oxidation, peroxyl radicals, and hydrogen peroxide) at pH 6.0. Our results highlight chemical degradations at Asn315, Met428, Trp277, and Trp313. A cross-comparison of the different Fc glycoforms, stress conditions, and the observed chemical reactions revealed that both the deamidation of Asn315 and the transformation of Trp277 into glycine hydroperoxide were glycan dependent during incubation for 3 months at 40 °C. Our data will show that different glycans not only affect chemical degradation differently but also do lead to different impurity profiles, which can affect chemical degradation. Copyright © 2016 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

  8. Raising awareness of Graves' orbitopathy with early warning cards.

    Science.gov (United States)

    Mitchell, Anna L; Hickey, Janis; Vaidya, Bijay; Mason, Rhianne; Ajjan, Ramzi; Zammitt, Nicola; Perros, Petros; Dayan, Colin

    2017-12-01

    Clinically significant Graves' orbitopathy (GO) develops in about 25% of those with Graves' disease (GD); most cases of GD in the UK are managed by endocrinologists. Despite this, patients report significant delays before a diagnosis of GO is made. Measures to increase awareness of the early signs of GO and establishing a fast-track referral pathway to specialist care should overcome these delays and potentially improve outcomes. We aimed to determine whether issuing a "GO early warning card" to all GD patients raises awareness of GO and facilitates early diagnosis, what percentage of cards result in a telephone contact, the number of "false reports" from card carriers and patient perceptions of the cards. We designed cards, detailing common GO symptoms and a telephone number for patients developing symptoms. Cards were distributed to 160 GD patients, without known GO, attending four endocrine clinics in the UK (December 2015-March 2016). We recorded telephone contacts over twelve months from when the last card was distributed and gathered patient feedback. The early warning cards were well received by patients in general. Over twelve months, ten telephone contacts from nine patients, all related to ocular symptoms, were received (6% of cards issued). Nine calls resulted in an additional clinic review (for eight patients), and four diagnoses of GO were made. This pilot study demonstrates that it is feasible to distribute GO early warning cards in clinic, and that they can be used to facilitate an early diagnosis of GO. © 2017 John Wiley & Sons Ltd.

  9. Characterization of the basic charge variants of a human IgG1

    Science.gov (United States)

    Lu, Franklin; Derfus, Gayle; Kluck, Brian; Nogal, Bartek; Emery, Craig; Summers, Christie; Zheng, Kai; Bayer, Robert; Amanullah, Ashraf

    2011-01-01

    We report a case study of an IgG1 with a unique basic charge variant profile caused by C-terminal proline amidation on either one or two heavy chains. The proline amidation was sensitive to copper ion concentration in the production media during cell culture: the higher the Cu2+ ion concentration, the higher the level of proline amidation detected. This conclusion was supported by the analysis of samples that revealed direct correlation between the proline amidation level observed from peptide maps and the level of basic peaks measured by imaged capillary isoelectric focusing and a pH gradient ion-exchange chromatography method. The importance of these observations to therapeutic antibody production is discussed. PMID:22123059

  10. The M/G/1 retrial queue: New descriptors of the customer's behavior

    Science.gov (United States)

    Amador, J.; Artalejo, J. R.

    2009-01-01

    We consider queuing systems where customers are not allowed to queue; instead of that they make repeated attempts, or retrials, in order to enter service after some time. The performance of telephone systems and communication networks modelled as retrial queues differs from standard waiting lines because typically the retrial group is an invisible queue which cannot be observed. As a result, the original flow of primary arrivals and the flow of repeated attempts become undistinguished. Our aim in this paper is to consider some aspects of this problem. Thus, we focus on the main retrial model of M/G/1 type and investigate the distribution of the successful and blocked events made by the primary customers and the retrial customers.

  11. Quantum key distribution using card, base station and trusted authority

    Energy Technology Data Exchange (ETDEWEB)

    Nordholt, Jane E.; Hughes, Richard John; Newell, Raymond Thorson; Peterson, Charles Glen; Rosenberg, Danna; McCabe, Kevin Peter; Tyagi, Kush T.; Dallmann, Nicholas

    2017-06-14

    Techniques and tools for quantum key distribution ("QKD") between a quantum communication ("QC") card, base station and trusted authority are described herein. In example implementations, a QC card contains a miniaturized QC transmitter and couples with a base station. The base station provides a network connection with the trusted authority and can also provide electric power to the QC card. When coupled to the base station, after authentication by the trusted authority, the QC card acquires keys through QKD with a trust authority. The keys can be used to set up secure communication, for authentication, for access control, or for other purposes. The QC card can be implemented as part of a smart phone or other mobile computing device, or the QC card can be used as a fillgun for distribution of the keys.

  12. Quantum key distribution using card, base station and trusted authority

    Science.gov (United States)

    Nordholt, Jane Elizabeth; Hughes, Richard John; Newell, Raymond Thorson; Peterson, Charles Glen; Rosenberg, Danna; McCabe, Kevin Peter; Tyagi, Kush T; Dallman, Nicholas

    2015-04-07

    Techniques and tools for quantum key distribution ("QKD") between a quantum communication ("QC") card, base station and trusted authority are described herein. In example implementations, a QC card contains a miniaturized QC transmitter and couples with a base station. The base station provides a network connection with the trusted authority and can also provide electric power to the QC card. When coupled to the base station, after authentication by the trusted authority, the QC card acquires keys through QKD with a trusted authority. The keys can be used to set up secure communication, for authentication, for access control, or for other purposes. The QC card can be implemented as part of a smart phone or other mobile computing device, or the QC card can be used as a fillgun for distribution of the keys.

  13. Credit card spending limit and personal finance: system dynamics approach

    Directory of Open Access Journals (Sweden)

    Mirjana Pejić Bach

    2014-03-01

    Full Text Available Credit cards have become one of the major ways for conducting cashless transactions. However, they have a long term impact on the well being of their owner through the debt generated by credit card usage. Credit card issuers approve high credit limits to credit card owners, thereby influencing their credit burden. A system dynamics model has been used to model behavior of a credit card owner in different scenarios according to the size of a credit limit. Experiments with the model demonstrated that a higher credit limit approved on the credit card decreases the budget available for spending in the long run. This is a contribution toward the evaluation of action for credit limit control based on their consequences.

  14. Preliminary stratigraphic and petrologic characterization of core samples from USW-G1, Yucca Mountain, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Waters, A.C.; Carroll, P.R. (eds.)

    1981-11-01

    Tuffs of the Nevada Test Site are currently under investigation to determine their potential for long-term storage of radioactive waste. As part of this program, hole USW-G1 was drilled to a depth of 6000 ft below the surface, in the central part of the Yucca Mountain area, Nevada Test Site, Nevada. Petrographic study of the USW-G1 core is presented in this report and shows the tuffs (which generally were variably welded ash flows) are partly recrystallized to a variety of secondary minerals. The important alteration products are zeolites (heulandite, clinoptilolite, mordenite and analcime), smectite clays with minor interstratified illite, albite, micas, potassium feldspar, and various forms of silica. Iijima`s zeolite zones I through IV of burial metamorphism can be recognized in the core. Zeolites are first observed at about the 1300-ft depth, and the high-temperature boundary of zeolite stability in this core occurs at about 4350 ft. Analcime persists, either metastably or as a retrograde mineral, deeper in the core. The oxidation state of Fe-Ti oxide minerals, through most of the core, increases as the degree of welding decreases, but towards the bottom of the hole, reducing conditions generally prevail. Four stratigraphic units transected by the core may be potentially favorable sites for a waste repository. These four units, in order of increasing depth in the core, are (1) the lower cooling unit of the Topopah Spring Member, (2) cooling unit II of the Bullfrog Member, (3) the upper part of the Tram tuff, and (4) the Lithic-rich tuff.

  15. Modeling intelligent agent beliefs in a card game scenario

    Science.gov (United States)

    Gołuński, Marcel; Tomanek, Roman; WÄ siewicz, Piotr

    In this paper we explore the problem of intelligent agent beliefs. We model agent beliefs using multimodal logics of belief, KD45(m) system implemented as a directed graph depicting Kripke semantics, precisely. We present a card game engine application which allows multiple agents to connect to a given game session and play the card game. As an example simplified version of popular Saboteur card game is used. Implementation was done in Java language using following libraries and applications: Apache Mina, LWJGL.

  16. Biometrics and ID Cards — Enablers for Personal Security

    Science.gov (United States)

    Reisen, Andreas

    The electronic ID card is a modernization and security project of the German Government. On the one hand, the multifunctional card is intended to boost security and the convenience of e-government and e-business applications. On the other hand, the new biometric ID card should allow citizens to use it as a travel document in the Schengen area and for specific destinations outside the European Union also in the future.

  17. Emulation of NFC student card in smart phone

    OpenAIRE

    BEDIČ, MATEJ

    2015-01-01

    In this thesis, we present the implementation of the identification card in a smartphone. We have developed a mobile application that allows emulation of a student card with NFC chip. Thus, instead of plastic NFC card, which is currently in use at the University of Ljubljana, student could use his smartphone for authentication on lectures or tutorials, borrow a book in the library or have access to certain premises of the Faculty. The thesis describes conceptual design and implementation of a...

  18. Lost, stolen or skimmed: Overcoming credit card fraud in South Africa

    African Journals Online (AJOL)

    A credit card is a convenient method of payment, but it does carry risks. The enormous growth in the use of credit cards has resulted in high levels of credit card fraud. Technological advances have allowed the perpetrators to produce counterfeit cards that resemble the genuine card so closely that it is difficult for ...

  19. Design and implementation of a smart card based billing system for ...

    African Journals Online (AJOL)

    A smart card based billing system for petroleum dispenser is just one of the many ways in which smart cards can be employed to make commerce efficient. It incorporates the use of smart card as its legal tender and a smart card reader embedded into the filling station dispenser design. The smart card reader processes the ...

  20. Volume of Requests for Internet Medicare Replacement Cards

    Data.gov (United States)

    Social Security Administration — This dataset provides monthly volumes at the national level from federal fiscal year 2008 onwards for Internet Medicare Replacement Card. The dataset includes only...

  1. Determinants of debit cards acceptance: An empirical investigation

    Energy Technology Data Exchange (ETDEWEB)

    Ismail, Shafinar; Adnan, Azimah; Azizi, Amsyar [Faculty of Business and Management, Universiti Teknologi MARA, Melaka 75300 (Malaysia); Bakri, Mohamed Hariri [Faculty of Technology Management And Technopreneurship, Universiti Teknikal Malaysia, Melaka 76100 (Malaysia); Zulkepli, Jafri [Faculty of Quantitative Science, Universiti Utara Malaysia, Sintok Kedah (Malaysia)

    2014-12-04

    These days, most of the Malaysians realize that the consumption of debit card will help them to reduce the household debt. Thus, it is important to analyse the acceptance of debit cards for further enhancement and expanding its market share in Malaysia. In addition, there is lacked of research being conducted on the determinants affecting the acceptance of debit cards among Malaysians. Thus, the study aimed to investigate the factors affecting the acceptance of debit cards. This study focuses on payment methods, consumer attitude, and safety of debit card in acceptance of debit cards. Questionnaires were distributed to the 300 respondents. The sampling procedure adopted was stratified random sampling. The data obtained were analysed using SPSS 20.0 which involves scale reliability, descriptive and regression analysis. The result indicates that payment methods, consumer attitude and safety are the determinants of debit cards acceptance. Safety is the best predictor as most of the customers are confidents to use debit cards because of the security being developed around these debit card transactions. The analyses presented in this study can be used by policymakers and managers as a guide to promote banking products and services. The findings achieved in this study will be of interest for practitioners and academics concerned with developments of the Malaysian banking industry.

  2. Survey of the Card Catalog in Medical Libraries *

    Science.gov (United States)

    Pachefsky, Reva

    1969-01-01

    A survey of present uses and arrangement of medical library card catalogs was made in order to determine current practices and trends. Attention was focused on the influences of MeSH on the card catalog. The results indicate that the prevalent type of card catalog found in medical libraries is the divided catalog. In addition, it appears that this catalog arrangement is gaining acceptance, and the trend is toward division. MeSH has an effect on the organization of the card catalog; libraries indicate that it is an influential factor in the decision to divide the catalog. PMID:5782258

  3. Survey of the card catalog in medical libraries.

    Science.gov (United States)

    Pachefsky, R

    1969-01-01

    A survey of present uses and arrangement of medical library card catalogs was made in order to determine current practices and trends. Attention was focused on the influences of MeSH on the card catalog. The results indicate that the prevalent type of card catalog found in medical libraries is the divided catalog. In addition, it appears that this catalog arrangement is gaining acceptance, and the trend is toward division. MeSH has an effect on the organization of the card catalog; libraries indicate that it is an influential factor in the decision to divide the catalog.

  4. Mathematical card magic fifty-two new effects

    CERN Document Server

    Mulcahy, Colm

    2013-01-01

    Mathematical card effects offer both beginning and experienced magicians an opportunity to entertain with a minimum of props. Featuring mostly original creations, Mathematical Card Magic: Fifty-Two New Effects presents an entertaining look at new mathematically based card tricks. Each chapter contains four card effects, generally starting with simple applications of a particular mathematical principle and ending with more complex ones. Practice a handful of the introductory effects and, in no time, you'll establish your reputation as a ""mathemagician."" Delve a little deeper into each chapter

  5. 17 CFR 270.17g-1 - Bonding of officers and employees of registered management investment companies.

    Science.gov (United States)

    2010-04-01

    ...: Amount of registered management investment company gross assets—at the end of the most recent fiscal... company at his last known residence address of (i) any cancellation, termination or modification of the... employees of registered management investment companies. 270.17g-1 Section 270.17g-1 Commodity and...

  6. CERN Access Cards and Access Authorisations

    CERN Multimedia

    2003-01-01

    From the 01/05/2003, all problems relating to access cards and refusal of access to any zone, building or experiment within CERN must be addressed to the Centrale de Surveillance des Accès (CSA building 120) on 78877 or send an e-mail to Access.Surveillance@cern.ch. The responsibles for CERN access control have put into place a procedure with the CSA, Service Enregistrement and the Technical Control Room, to make sure that all problems get resolved in a proper and timely manner.

  7. Mated Fingerprint Card Pairs 2 (MFCP2)

    Science.gov (United States)

    NIST Mated Fingerprint Card Pairs 2 (MFCP2) (Web, free access)   NIST Special Database 14 is being distributed for use in development and testing of automated fingerprint classification and matching systems on a set of images which approximate a natural horizontal distribution of the National Crime Information Center (NCIC) fingerprint classes. A newer version of the compression/decompression software on the CDROM can be found at the website http://www.nist.gov/itl/iad/ig/nigos.cfm as part of the NBIS package.

  8. Redesign Based on Card Sorting: How Universally Applicable are Card Sort Results?

    NARCIS (Netherlands)

    Wentzel, M.J.; Beerlage-de Jong, Nienke; van der Geest, Thea; Duffy, Vincent G.

    2016-01-01

    Card sort studies can facilitate developers to create an information structure for their website or application. In addition, this human-centered design method provides researchers with insights into the target group’s mental models regarding the information domain under study. In this method,

  9. CARDING DAN MAHASISWA (Studi Kasus Tentang Fenomena Carding Di Kalangan Mahasiswa Fakultas Ilmu Sosial Dan Ilmu Politik Universitas Brawijaya Malang)

    OpenAIRE

    0710010048, SEPTIAN ADRI

    2015-01-01

    Penelitian ini membahas tentang pola jaringan sosial mahasiswa pelaku carding di Fakultas Ilmu Sosial dan Ilmu Politik Universitas Brawijaya Malang. Para carder tersebut bekerja sama dalam melakukan carding yang kemudian membentuk modal sosial diantara mereka. Tujuan dari penelitian ini adalah untuk mengetahui modal sosial yang ada pada para carder, serta untuk mengetahui pola jaringan sosial mahasiswa sebagai pelaku carding. Penelitian ini menggunakan teori modal sosial dari Robert D. Putnam...

  10. Structural Properties of Polyphenols Causing Cell Cycle Arrest at G1 Phase in HCT116 Human Colorectal Cancer Cell Lines

    Directory of Open Access Journals (Sweden)

    Yoongho Lim

    2013-08-01

    Full Text Available Plant-derived polyphenols are being tested as chemopreventive agents; some polyphenols arrest the cell cycle at G1 phase, whereas others inhibit cell cycle proliferation at G2/M phase. Therefore, polyphenols have been proposed to inhibit cell cycle progression at different phases via distinct mechanisms. Indeed, our previous studies showed that small structural differences in polyphenols cause large differences in their biological activities; however, the details of the structural properties causing G1 cell cycle arrest remain unknown. In this study, we prepared 27 polyphenols, including eight different scaffolds, to gain insight into the structural conditions that arrest the cell cycle at G1 phase in a quantitative structure–activity relationship study. We used cell cycle profiles to determine the biophores responsible for G1 cell cycle arrest and believe that the biophores identified in this study will help design polyphenols that cause G1 cell cycle arrest.

  11. G1/ELE Functions in the Development of Rice Lemmas in Addition to Determining Identities of Empty Glumes.

    Science.gov (United States)

    Liu, Mengjia; Li, Haifeng; Su, Yali; Li, Wenqiang; Shi, Chunhai

    2016-01-01

    Rice empty glumes, also named sterile lemmas or rudimentary lemmas according to different interpretations, are distinct from lemmas in morphology and cellular pattern. Consistently, the molecular mechanism to control the development of lemmas is different from that of empty glumes. Rice LEAFY HULL STERILE1(OsLHS1) and DROOPING LEAF(DL) regulate the cellular pattern and the number of vascular bundles of lemmas respectively, while LONG STERILE LEMMA1 (G1)/ELONGATED EMPTY GLUME (ELE) and PANICLE PHYTOMER2 (PAP2)/OsMADS34 determine identities of empty glumes. Though some progress has been made, identities of empty glumes remain unclear, and genetic interactions between lemma genes and glume genes have been rarely elucidated. In this research, a new G1/ELE mutant g1-6 was identified and the phenotype was analyzed. Similar to previously reported mutant lines of G1/ELE, empty glumes of g1-6 plants transform into lemma-like organs. Furthermore, Phenotypes of single and double mutant plants suggest that, in addition to their previously described gene-specific functions, G1/ELE and OsLHS1 play redundant roles in controlling vascular bundle number, cell volume, and cell layer number of empty glumes and lemmas. Meanwhile, expression patterns of G1/ELE in osmads1-z flowers and OsLHS1 in g1-6 flowers indicate they do not regulate each other at the level of transcription. Finally, down-regulation of the empty glume gene OsMADS34/PAP2 and ectopic expression of the lemma gene DL, in the g1-6 plants provide further evidence that empty glumes are sterile lemmas. Generally, our findings provided valuable information for better understanding functions of G1 and OsLHS1 in flower development and identities of empty glumes.

  12. Antiviral therapy in chronic hepatitis C (G1 in Russia: cost and effectiveness

    Directory of Open Access Journals (Sweden)

    A. V. Rudakova

    2015-01-01

    Full Text Available Genotype 1 HCV treatment in Russia assume as bitherapy (pegylated interferon – PG plus ribavirin – RBV as three therapy based on HCV protease inhibitor such as telaprevir (TLV, boceprevir (BCV or simeprevir (SMV plus PG/RBV. Medical technologies characterize neither clinical effectiveness, safety profile nor cost-effectiveness so it’s crucial to assess different costs related antiviral regimens. Three therapy costs for naïve patients including TLV, BCV, SMV are higher bitherapy 2,6; 2,5; 3,1 times accordingly. Similar TLV and BCV effectiveness for naïve patients defines TLV or BCV as the preferable 1-st line regimen, depending on regional features of pricing. SMV and TLV efficacy is similar among naïve patients and ralapsers but SMV is affordable for partially responders and non-responders after previous bitherapy. SMV cost is 1,4 times higher vs TLV but SMV has improved tolerability, less drug-drug interactions and shorter course. Insufficient bitherapy effectiveness for G1 HCV (SVR 24 – 39%-55% is required repeated course of three therapy for half of patient population. The first line regimen based on innovation will improve clinical outcomes for more patients and provide cost saving vs previous bitherapy based on PG/RBV. 

  13. Dimethylfumarate effectively inhibits lymphangiogenesis via p21 induction and G1 cell cycle arrest.

    Science.gov (United States)

    Valesky, Eva Maria; Hrgovic, Igor; Doll, Monika; Wang, Xiao-Fan; Pinter, Andreas; Kleemann, Johannes; Kaufmann, Roland; Kippenberger, Stefan; Meissner, Markus

    2016-03-01

    Different pathologies, such as lymphoedema, cancer or psoriasis, are associated with abnormal lymphatic vessel formation. Therefore, influencing lymphangiogenesis is an interesting target. Recent evidence suggests that dimethylfumarate (DMF), an antipsoriatic agent, might have antitumorigenic and antilymphangiogenic properties. To prove this assumption, we performed proliferation and functional assays with primary human dermal lymphendothelial cells (DLEC). We could demonstrated that DMF suppresses DLEC proliferation and formation of capillary-like structures. Underlying apoptotic mechanisms could be ruled out. Cell cycle analysis demonstrated a pronounced G1-arrest. Further evaluations revealed increases in p21 expression. In addition, DMF suppressed Cyclin D1 and Cyclin A expression in a concentration-dependent manner. p21 knockdown experiments demonstrated a p21-dependent mechanism of regulation. Further analysis showed an increased p21 mRNA expression after DMF treatment. This transcriptional regulation was enforced by post-transcriptional and post-translational mechanisms. In addition, we could demonstrate that the combination of a proteasomal inhibitor and DMF superinduced the p21 expression. Hence, DMF is a new antilymphangiogenic compound and might be used in various illnesses associated with increased lymphangiogenesis. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  14. A gradient in the duration of the G1 phase in the murine neocortical proliferative epithelium

    Science.gov (United States)

    Miyama, S.; Takahashi, T.; Nowakowski, R. S.; Caviness, V. S. Jr

    1997-01-01

    Neuronogenesis in the neocortical pseudostratified ventricular epithelium (PVE) is initiated rostrolaterally and progresses caudo-medially as development progresses. Here we have measured the cytokinetic parameters and the fractional neuronal output parameter, Q, of laterally located early-maturing regions over the principal embryonic days (E12-E15) of neocortical neuronogenesis in the mouse. These measures are compared with ones previously made of a medial, late-maturing portion of the PVE. Laterally, as medially, the duration of the neuronogenetic interval is 6 days and comprises 11 integer cell cycles. Also, in both lateral and medial areas the length of G1 phase (TG1) increases nearly 4-fold and is the only cell cycle parameter to change. Q progresses essentially identically laterally and medially with respect to the succession of integer cell cycles. Most importantly, from E12 to E13 there is a steeply declining lateral to medial gradient in TG1. The gradient is due both to the lateral to medial graded stage of neuronogenesis and to the stepwise increase in TG1 with each integer cycle during the neuronogenetic interval. To our knowledge this gradient in TG1 of the cerebral PVE is the first cell biological gradient to be demonstrated experimentally in such an extensive proliferative epithelial sheet. We suggest that this gradient in TG1 is the cellular mechanism for positionally encoding a protomap of the neocortex within the PVE.

  15. Disrupted Asteroid P/2016 G1. II. Follow-up Observations from the Hubble Space Telescope

    Science.gov (United States)

    Moreno, F.; Licandro, J.; Mutchler, M.; Cabrera-Lavers, A.; Pinilla-Alonso, N.; Pozuelos, F. J.

    2017-12-01

    After the early observations of the disrupted asteroid P/2016 G1 with the 10.4 m Gran Telescopio Canarias (GTC) and modeling of the dust ejecta, we have performed a follow-up observational campaign of this object using the Hubble Space Telescope (HST) during two epochs (2016 June 28 and July 11). The analysis of these HST images with the same model inputs obtained from the GTC images revealed a good consistency with the predicted evolution from the GTC images, so that the model is applicable to the entire observational period from 2016 late April to early July. This result confirms that the resulting dust ejecta was caused by a relatively short-duration event with onset about 350 days before perihelion and spanning about 30 days (HWHM). For a size distribution of particles with a geometric albedo of 0.15, having radii limits of 1 μm and 1 cm, and following a power-law with index -3.0, the total dust mass ejected is ˜2 × 107 kg. As was the case with the GTC observations, no condensations in the images that could be attributed to a nucleus or fragments released after the disruption event were found. However, the higher limiting magnitude reachable with the HST images in comparison to those from GTC allowed us to impose a more stringent upper limit to the observed fragments of ˜30 m.

  16. Biosimilarity Assessments of Model IgG1-Fc Glycoforms Using a Machine Learning Approach.

    Science.gov (United States)

    Kim, Jae Hyun; Joshi, Sangeeta B; Tolbert, Thomas J; Middaugh, C Russell; Volkin, David B; Smalter Hall, Aaron

    2016-02-01

    Biosimilarity assessments are performed to decide whether 2 preparations of complex biomolecules can be considered "highly similar." In this work, a machine learning approach is demonstrated as a mathematical tool for such assessments using a variety of analytical data sets. As proof-of-principle, physical stability data sets from 8 samples, 4 well-defined immunoglobulin G1-Fragment crystallizable glycoforms in 2 different formulations, were examined (see More et al., companion article in this issue). The data sets included triplicate measurements from 3 analytical methods across different pH and temperature conditions (2066 data features). Established machine learning techniques were used to determine whether the data sets contain sufficient discriminative power in this application. The support vector machine classifier identified the 8 distinct samples with high accuracy. For these data sets, there exists a minimum threshold in terms of information quality and volume to grant enough discriminative power. Generally, data from multiple analytical techniques, multiple pH conditions, and at least 200 representative features were required to achieve the highest discriminative accuracy. In addition to classification accuracy tests, various methods such as sample space visualization, similarity analysis based on Euclidean distance, and feature ranking by mutual information scores are demonstrated to display their effectiveness as modeling tools for biosimilarity assessments. Copyright © 2016 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

  17. Screening of recombinant glycosyltransferases reveals the broad acceptor specificity of stevia UGT-76G1.

    Science.gov (United States)

    Dewitte, Griet; Walmagh, Maarten; Diricks, Margo; Lepak, Alexander; Gutmann, Alexander; Nidetzky, Bernd; Desmet, Tom

    2016-09-10

    UDP-glycosyltransferases (UGTs) are a promising class of biocatalysts that offer a sustainable alternative for chemical glycosylation of natural products. In this study, we aimed to characterize plant-derived UGTs from the GT-1 family with an emphasis on their acceptor promiscuity and their potential application in glycosylation processes. Recombinant expression in E. coli provided sufficient amounts of enzyme for the in-depth characterization of the salicylic acid UGT from Capsella rubella (UGT-SACr) and the stevia UGT from Stevia rebaudiana (UGT-76G1Sr). The latter was found to have a remarkably broad specificity with activities on a wide diversity of structures, from aliphatic and branched alcohols, over small phenolics to larger flavonoids, terpenoids and even higher glycoside compounds. As an example for its industrial potential, the glycosylation of curcumin was thoroughly evaluated. Under optimized conditions, 96% of curcumin was converted within 24h into the corresponding curcumin β-glycosides. In addition, the reaction was performed in a coupled system with sucrose synthase from Glycine max, to enable the cost-efficient (re)generation of UDP-Glc from sucrose as abundant and renewable resource. Copyright © 2016 Elsevier B.V. All rights reserved.

  18. Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease.

    Science.gov (United States)

    Matsunaga, Naoya; Ikeda, Eriko; Kakimoto, Keisuke; Watanabe, Miyako; Shindo, Naoya; Tsuruta, Akito; Ikeyama, Hisako; Hamamura, Kengo; Higashi, Kazuhiro; Yamashita, Tomohiro; Kondo, Hideaki; Yoshida, Yuya; Matsuda, Masaki; Ogino, Takashi; Tokushige, Kazutaka; Itcho, Kazufumi; Furuichi, Yoko; Nakao, Takaharu; Yasuda, Kaori; Doi, Atsushi; Amamoto, Toshiaki; Aramaki, Hironori; Tsuda, Makoto; Inoue, Kazuhide; Ojida, Akio; Koyanagi, Satoru; Ohdo, Shigehiro

    2016-11-01

    Chronic kidney disease (CKD) is a global health problem, and novel therapies to treat CKD are urgently needed. Here, we show that inhibition of G0/G1 switch 2 (G0s2) ameliorates renal inflammation in a mouse model of CKD. Renal expression of chemokine (C-C motif) ligand 2 (Ccl2) was increased in response to p65 activation in the kidneys of wild-type 5/6 nephrectomy (5/6Nx) mice. Moreover, 5/6Nx Clk/Clk mice, which carry homozygous mutations in the gene encoding circadian locomotor output cycles kaput (CLOCK), did not exhibit aggravation of apoptosis or induction of F4/80-positive cells. The renal expression of G0s2 in wild-type 5/6Nx mice was important for the transactivation of Ccl2 by p65. These pathologies were ameliorated by G0s2 knockdown. Furthermore, a novel small-molecule inhibitor of G0s2 expression was identified by high-throughput chemical screening, and the inhibitor suppressed renal inflammation in 5/6Nx mice. These findings indicated that G0s2 inhibitors may have applications in the treatment of CKD. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  19. Emergence and Characterization of Unusual DS-1-Like G1P[8] Rotavirus Strains in Children with Diarrhea in Thailand.

    Directory of Open Access Journals (Sweden)

    Satoshi Komoto

    Full Text Available The emergence and rapid spread of unusual DS-1-like G1P[8] rotaviruses in Japan have been recently reported. During rotavirus surveillance in Thailand, three DS-1-like G1P[8] strains (RVA/Human-wt/THA/PCB-180/2013/G1P[8], RVA/Human-wt/THA/SKT-109/2013/G1P[8], and RVA/Human-wt/THA/SSKT-41/2013/G1P[8] were identified in stool specimens from hospitalized children with severe diarrhea. In this study, we sequenced and characterized the complete genomes of strains PCB-180, SKT-109, and SSKT-41. On whole genomic analysis, all three strains exhibited a unique genotype constellation including both genogroup 1 and 2 genes: G1-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2. This novel genotype constellation is shared with Japanese DS-1-like G1P[8] strains. Phylogenetic analysis revealed that the G/P genes of strains PCB-180, SKT-109, and SSKT-41 appeared to have originated from human Wa-like G1P[8] strains. On the other hand, the non-G/P genes of the three strains were assumed to have originated from human DS-1-like strains. Thus, strains PCB-180, SKT-109, and SSKT-41 appeared to be derived through reassortment event(s between Wa-like G1P[8] and DS-1-like human rotaviruses. Furthermore, strains PCB-180, SKT-109, and SSKT-41 were found to have the 11-segment genome almost indistinguishable from one another in their nucleotide sequences and phylogenetic lineages, indicating the derivation of the three strains from a common origin. Moreover, all the 11 genes of the three strains were closely related to those of Japanese DS-1-like G1P[8] strains. Therefore, DS-1-like G1P[8] strains that have emerged in Thailand and Japan were assumed to have originated from a recent common ancestor. To our knowledge, this is the first report on whole genome-based characterization of DS-1-like G1P[8] strains that have emerged in an area other than Japan. Our observations will provide important insights into the evolutionary dynamics of emerging DS-1-like G1P[8] rotaviruses.

  20. Disritmias cardíacas e anestesia

    Directory of Open Access Journals (Sweden)

    Michelle Nacur Lorentz

    2011-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: As disritmias são complicações relativamente comuns no período perioperatório, devendo ser diagnosticadas e adequadamente tratadas pelo anestesiologista quando houver indicação para tal. Este artigo foi elaborado com o objetivo de revisar os aspectos mais relevantes das disritmias cardíacas para o anestesiologista, bem como estabelecer relação de causa e efeito entre os fármacos utilizados no período perioperatório e as disritmias. CONTEÚDO: São apresentados neste artigo os mecanismos das disritmias, os fármacos que potencialmente causam disritmias, além do diagnóstico e tratamento no período perioperatório. CONCLUSÕES: As disritmias que ocorrem no período perioperatório muitas vezes não demandam tratamento e, em outras tantas, o tratamento pode gerar uma verdadeira iatrogenia. Portanto, o conhecimento das disritmias cardíacas e dos fatores que podem desencadeá-las possibilita ao anestesiologista melhor abordagem perioperatória, evitando tratamentos equivocados ou desnecessários.

  1. Comparison of fixation disparity curve parameters obtained with the Wesson and Saladin fixation disparity cards

    National Research Council Canada - National Science Library

    Ngan, Janice; Goss, David A; Despirito, Joseph

    2005-01-01

    This study compared fixation curve parameters with two commercially available fixation disparity cards, one that has been available for several years, the Wesson card, and a new one, the Saladin card...

  2. Cleavage of IgG1 in gingival crevicular fluid is associated with the presence of Porphyromonas gingivalis.

    Science.gov (United States)

    Guentsch, A; Hirsch, C; Pfister, W; Vincents, B; Abrahamson, M; Sroka, A; Potempa, J; Eick, S

    2013-08-01

    Immunoglobulin (Ig) G1 plays an important role in the adaptive immune response. Kgp, a lysine-specific cysteine protease from Porphyromonas gingivalis, specifically hydrolyses IgG1 heavy chains. The purpose of this study was to examine whether cleavage of IgG1 occurs in gingival crevicular fluid (GCF) in vivo, and whether there is any association with the presence of Porphyromonas gingivalis and other periodontopathogens. GCF was obtained from nine patients with aggressive periodontitis, nine with chronic periodontitis and five periodontally healthy individuals. The bacterial loads of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Treponema denticola, Prevotella intermedia and Tannerella forsythia were analysed by real-time polymerase chain reaction, and the presence and cleavage of IgG1 and IgG2 were determined using Western blotting. Kgp levels were measured by ELISA. Cleaved IgG1 was identified in the GCF from 67% of patients with aggressive periodontitis and in 44% of patients with chronic periodontitis. By contrast, no cleaved IgG1 was detectable in healthy controls. No degradation of IgG2 was detected in any of the samples, regardless of health status. Porphyromonas gingivalis was found in high numbers in all samples in which cleavage of IgG1 was detected (P Porphyromonas gingivalis (r = 0.425, P Porphyromonas gingivalis. © 2012 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  3. Bancroftian filariasis: the patterns of filarial-specific immunoglobulin G1 (IgG1), IgG4, and circulating antigens in an endemic community of northeastern Tanzania

    DEFF Research Database (Denmark)

    Simonsen, P E; Lemnge, M M; Msangeni, H A

    1996-01-01

    in the examined population was 29%. Fifty-one percent of the population were positive for IgG1 (39% among mf-positive individuals and 63% among mf-negative individuals), whereas 90% were positive for IgG4 (97% among mf-positives and 87% among mf-negatives). The levels of IgG1 and IgG4 were clearly related to mf......The profile of filarial-specific immunoglobulin G1 (IgG1), IgG4, and Wuchereria bancrofti-specific circulating antigen (Og4C3) was analyzed in individuals one year of age and older in a community with high endemicity for Bancroftian filariasis. The overall microfilarial (mf) prevalence...

  4. Designing minimum data sets of health smart card system

    Directory of Open Access Journals (Sweden)

    Mohtaram Nematollahi

    2014-10-01

    Full Text Available Introduction: Nowadays different countries benefit from health system based on health cards and projects related to smart cards. Lack of facilities which cover this technology is obvious in our society. This paper aims to design Minimum Data Sets of Health Smart Card System for Iran. Method: This research was an applied descriptive study. At first, we reviewed the same projects and guidelines of selected countries and the proposed model was designed in accordance to the country’s needs, taking people’s attitude about it by Delphi technique. A data analysis in study stage of MDS(Minimum Data Sets of Health Smart Card in the selective countries was done by comparative tables and determination of similarities and differences of the MDS. In the stage of gaining credit for model, it was accomplished with descriptive statistics to the extent of absolute and relative frequency through SPSS (version 16. Results: MDS of Health Smart Card for Iran is presented in the patient’s card and health provider’s card on basisof studiesin America, Australia, Turkey and Belgium and needs of our country and after doing Delphi technique with 94 percent agreement confirmed. Conclusion: Minimum Data Sets of Health Smart Card provides continuous care for patients and communication among providers. So, it causes a decrease in the complications of threatening diseases. Collection of MDS of diseases increases the quality of care assessment

  5. Developing efficient blinded attribute certificates on smart cards via pairings

    NARCIS (Netherlands)

    Batina, L.; Hoepman, J.H.; Jacobs, B.; Mostowski, W.; Vullers, P.

    2010-01-01

    This paper describes an elementary protocol to prove possession of anonymous credentials together with its implementation on smart cards. The protocol uses self-blindable attribute certificates represented as points on an elliptic curve (which are stored on the card). These certificates are verified

  6. Retrospective Conversion of Card catalogue at the University of ...

    African Journals Online (AJOL)

    The National University of Lesotho Library has fully computerised all its housekeeping routines and one of the major achievements with this regard is the automation of its card catalogue. Currently, about 90% of the library's card catalogue has been converted to machine-readable format. This article reports how the ...

  7. Health cards as a part of French health telematics.

    Science.gov (United States)

    Kleinebreil, Line; Saba, Renato; Razafindramanana, Njaka

    2003-01-01

    The concept of the healthcare smart card is being discussed by more and more countries all over the world since the late eighties. After a long period of pilots, health cards are now an important part of the French health telematics. How did this happen? This paper highlights the prerequisite for a large implementation.

  8. Instructional Guidance in Reciprocal Peer Tutoring With Task Cards

    Science.gov (United States)

    Iserbyt, Peter; Elen, Jan; Behets, Daniel

    2010-01-01

    This article addresses the issue of instructional guidance in reciprocal peer tutoring with task cards as learning tools. Eighty-six Kinesiology students (age 17-19 years) were randomized across four reciprocal peer tutoring settings, differing in quality and quantity of guidance, to learn Basic Life Support (BLS) with task cards. The separate and…

  9. Western North Carolina report card on forest sustainability

    Science.gov (United States)

    Susan Fox; Bill Jackson; Sarah Jackson; Gary Kauffmann; Mary Carol Koester; Robert Mera; Terry Seyden; Charles Van Sickle; Sealy Chipley; Jim Fox; Jeff Hicks; Matt Hutchins; Karin Lichtenstein; Kelsie Nolan; Todd Pierce; Beth Porter

    2011-01-01

    Western North Carolina encompasses 4.8 million acres of highly valued temperate forests. To help address future management and conservation decisions surrounding these resources, the report card evaluates environmental, social, and economic conditions in recent decades across an 18 county area. The report card describes the status of indicators of forest sustainability...

  10. Towards testability in smart card operating system design

    NARCIS (Netherlands)

    Hartel, Pieter H.; Cordonnier, V.; de Jong, Eduard K.; Quisquater, J.J.

    1994-01-01

    The operating system of a smart card is a safety critical system. Distributed in millions, smart cards with their small 8-bit CPU support applications where transferred values are only protected by the strength of a cryptographic protocol. This strength goes no further than the implementation of the

  11. Identification of Clusters in Travel Patterns using Smart Card Data

    DEFF Research Database (Denmark)

    Reinau, Kristian Hegner; Harder, Henrik

    2016-01-01

    This article is the first contribution, which explores the potential of smart card data in relation to optimization of public transport in a peripheral monocentric region. A modularity analysis is made using smart card data collected in Northern Jutland in Marts and July 2014, and the analysis re...

  12. 75 FR 81721 - Debit Card Interchange Fees and Routing

    Science.gov (United States)

    2010-12-28

    ... cards have the capability to accept PIN-based debit transactions. According to the Board's survey of... unaffiliated PIN-based networks. Transaction routing. The Board proposes to prohibit issuers and payment card... two unaffiliated PIN debit networks. The Board recognizes that the nature of a three-party system...

  13. Using Playing Cards to Simulate a Molecular Clock

    Science.gov (United States)

    Westerling, Karin E.

    2008-01-01

    Changes in DNA base-repair may serve as an indicator of the time elapsed since divergence from a common ancestor. DNA sequences can now be analyzed. The simulation presented in this article allows students to observe the accumulation of changes in a randomly mutating sequence of playing cards. The cards are analogous to DNA nucleotide or protein…

  14. Predicting credit card behavior: a study in neuroeconomics.

    Science.gov (United States)

    Spinella, Marcello; Lester, David; Yang, Bijou

    2005-06-01

    In a sample of 139 community residents, credit card ownership was associated with age, sex, income, attitudes toward credit cards and toward money, and scores on a verbal measure of prefrontal cortical dysfunction, supporting a neuroeconomic approach to economic decision-making.

  15. Students Beat the Queue and Produce Their Own Library Cards

    Science.gov (United States)

    Lockton, Laurence

    2006-01-01

    In the past, it took the library staff of the University of Bath in United Kingdom around two weeks each autumn to produce cards for the main intake of its undergraduates. In this article, the author describes how he transformed the school's traditional library card production into a low-cost self-service system. He also describes how the new…

  16. IR Cards: Inquiry-Based Introduction to Infrared Spectroscopy

    Science.gov (United States)

    Bennett, Jacqueline; Forster, Tabetha

    2010-01-01

    As infrared spectroscopy (IR) is frequently used in undergraduate organic chemistry courses, an inductive introduction to IR spectroscopy that uses index cards printed with spectra, structures, and chemical names is described. Groups of students are given an alphabetized deck of these "IR cards" to sort into functional groups. The students then…

  17. Converting Inhouse Subject Card Files to Electronic Keyword Files.

    Science.gov (United States)

    Culmer, Carita M.

    The library at Phoenix College developed the Controversial Issues Files (CIF), a "home made" card file containing references pertinent to specific ongoing assignments. Although the CIF had proven itself to be an excellent resource tool for beginning researchers, it was cumbersome to maintain in the card format, and was limited to very…

  18. Modelling of aflatoxin G1 reduction by kefir grain using response surface methodology.

    Science.gov (United States)

    Ansari, Farzaneh; Khodaiyan, Faramarz; Rezaei, Karamatollah; Rahmani, Anosheh

    2015-01-01

    Aflatoxin G1 (AFG1) is one of the main toxic contaminants in pistachio nuts and causes potential health hazards. Hence, AFG1 reduction is one of the main concerns in food safety. Kefir-grains contain symbiotic association of microorganisms well known for their aflatoxin decontamination effects. In this study, a central composite design (CCD) using response surface methodology (RSM) was applied to develop a model in order to predict AFG1 reduction in pistachio nuts by kefir-grain (already heated at 70 and 110°C). The independent variables were: toxin concentration (X1: 5, 10, 15, 20 and 25 ng/g), kefir-grain level (X2: 5, 10, 20, 10 and 25%), contact time (X3: 0, 2, 4, 6 and 8 h), and incubation temperature (X4: 20, 30, 40, 50 and 60°C). There was a significant reduction in AFG1 (p kefir-grain used. The variables including X1, X3 and the interactions between X2-X4 as well as X3-X4 have significant effects on AFG1 reduction. The model provided a good prediction of AFG1 reduction under the assay conditions. Optimization was used to enhance the efficiency of kefir-grain on AFG1 reduction. The optimum conditions for the highest AFG1 reduction (96.8%) were predicted by the model as follows: toxin concentration = 20 ng/g, kefir-grain level = 10%, contact time = 6 h, and incubation temperature = 30°C which validated practically in six replications.

  19. SUN1 silencing inhibits cell growth through G0/G1 phase arrest in lung adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Huang W

    2017-06-01

    Full Text Available Weiyi Huang,* Haihua Huang,* Lei Wang, Jiong Hu, Weifeng Song Department of Oncology, The First People’s Hospital Affiliated to Shanghai Jiaotong University, Shanghai, People’s Republic of China *These authors contributed equally to this work Purpose: Cytoskeleton is critical for carcinoma cell proliferation, migration, and invasion. Sad-1 and UNC-84 domain containing 1 (SUN1 is one of the core linkers of nucleoskeleton and cytoskeleton. However, the functions of SUN1 in lung adenocarcinoma are largely unknown.Methods: In this study, we first transduced the lentivirus delivering the short hairpin RNA (shRNA against SUN1 to lung adenocarcinoma cells (A549 and 95D cells with high efficiency. After lentivirus infection, quantitative real-time polymerase chain reaction and Western blotting were used to detect the expressions of SUN1 mRNA and protein. The cell proliferation and colony formation were detected by MTT assay and colony formation assay, respectively. The cell distribution in the cell cycle was analyzed by flow cytometry.Results: Both mRNA and protein levels of SUN1 were significantly decreased in A549 and 95D cells after lentivirus infection, as indicated by quantitative real-time polymerase chain reaction and Western blot. Next, we found that cell proliferation and colony formation were markedly reduced in SUN1 silenced cells. Moreover, suppression of SUN1 led to cell cycle arrest at G0/G1 phase. Furthermore, Cyclin D1, CDK6, and CDK2 expressions were obviously reduced in A549 cells after SUN1 silencing.Conclusion: These results suggest that SUN1 plays an essential role in proliferation of lung adenocarcinoma cells in vitro and may be used as a potential therapeutic target for the treatment of lung adenocarcinoma in the future. Keywords: SUN1, lung cancer, proliferation

  20. Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System

    Directory of Open Access Journals (Sweden)

    Stephen T. Hallett

    2017-10-01

    Full Text Available Summary: Selective recruitment of protein kinases to the Hsp90 system is mediated by the adaptor co-chaperone Cdc37. We show that assembly of CDK4 and CDK6 into protein complexes is differentially regulated by the Cdc37-Hsp90 system. Like other Hsp90 kinase clients, binding of CDK4/6 to Cdc37 is blocked by ATP-competitive inhibitors. Cdc37-Hsp90 relinquishes CDK6 to D3- and virus-type cyclins and to INK family CDK inhibitors, whereas CDK4 is relinquished to INKs but less readily to cyclins. p21CIP1 and p27KIP1 CDK inhibitors are less potent than the INKs at displacing CDK4 and CDK6 from Cdc37. However, they cooperate with the D-type cyclins to generate CDK4/6-containing ternary complexes that are resistant to cyclin D displacement by Cdc37, suggesting a molecular mechanism to explain the assembly factor activity ascribed to CIP/KIP family members. Overall, our data reveal multiple mechanisms whereby the Hsp90 system may control formation of CDK4- and CDK6-cyclin complexes under different cellular conditions. : Hallett et al. reconstitute CDK4/6 client kinase handover from Cdc37-Hsp90 to CDK regulatory partners and propose a model for the assembly factor activity of CIP/KIP CDK inhibitors. They find that CDK4/6 inhibitors in clinical use can displace G1 CDKs from the Cdc37-Hsp90 chaperone system at submicromolar concentrations. Keywords: Cdc37, CDK, chaperone, CIP/KIP, cyclin D, Hsp90, INK, kinase, palbociclib, ribociclib

  1. Acetylbritannilactone induces G1 arrest and apoptosis in vascular smooth muscle cells.

    Science.gov (United States)

    Liu, Bin; Han, Mei; Sun, Rong-Hua; Wang, Jun-Jie; Liu, Yue-Ping; Wen, Jin-Kun

    2011-05-19

    The present study was designed to determine the effects of Acetylbritannilactone (ABL), a naturally occurring Inula britannica L., on vascular smooth muscle cell (VSMC) proliferation and apoptosis. In vitro experiments were performed to evaluate the effects of ABL on the VSMC cycle and apoptosis stimulated by chemoattractant. In addition, to examine the effects of ABL in vivo, balloon injury to rat carotid arteries was performed. ABL treatment inhibited platelet-derived growth factor (PDGF) induced DNA synthesis and proliferation in cultured VSMC. Such growth-inhibitory effects of ABL were associated with G1 phase arrest, which were correlated with reduction of cyclins D1, A, and E expression and cyclin-dependent kinase (CDK) 2, CDK4, and CDK6 proteins, increased the CDK inhibitory protein p21cip1 expression, and enhanced the binding of p21cip1 to CDKs. In addition, ABL also induced apoptosis in proliferative VSMCs, as evidenced by the induction of a higher ratio of Bax/Bcl-2, activation of caspase-9, caspase-3, and the cleavage of endogenous substrate Poly (ADP-ribose) polymerase. However, pretreatment with pan-caspases inhibitor (z-VAD-fmk) only partially reversed ABL-induced apoptosis, suggesting the involvement of both caspase-dependent and caspase-independent pathways in these processes. Furthermore, the effects of ABL on VSMCs were associated with the downregulation of extracellular signal-regulated kinase (ERK) 1/2 signaling pathways. In vivo, ABL (26 mg/kg/day) significantly suppressed injury-induced ERK1/2 phosphorylation, and increased VSMC apoptosis 14 days after balloon injury. Our findings demonstrated that ABL was capable of suppressing the abnormal VSMC proliferation, accompanied by the induction of apoptosis in vivo and in vitro. It suggested that ABL could be considered a pharmacological candidate for the prevention of restenosis after balloon angioplasty. Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.

  2. The g0/g1 switch gene 2 is an important regulator of hepatic triglyceride metabolism.

    Directory of Open Access Journals (Sweden)

    Yinfang Wang

    Full Text Available Nonalcoholic fatty liver disease is associated with obesity and insulin resistance. Factors that regulate the disposal of hepatic triglycerides contribute to the development of hepatic steatosis. G0/G1 switch gene 2 (G0S2 is a target of peroxisome proliferator-activated receptors and plays an important role in regulating lipolysis in adipocytes. Therefore, we investigated whether G0S2 plays a role in hepatic lipid metabolism. Adenovirus-mediated expression of G0S2 (Ad-G0S2 potently induced fatty liver in mice. The liver mass of Ad-G0S2-infected mice was markedly increased with excess triglyceride content compared to the control mice. G0S2 did not change cellular cholesterol levels in hepatocytes. G0S2 was found to be co-localized with adipose triglyceride lipase at the surface of lipid droplets. Hepatic G0S2 overexpression resulted in an increase in plasma Low-density lipoprotein (LDL/Very-Low-density (VLDL lipoprotein cholesterol level. Plasma High-density lipoprotein (HDL cholesterol and ketone body levels were slightly decreased in Ad-G0S2 injected mice. G0S2 also increased the accumulation of neutral lipids in cultured HepG2 and L02 cells. However, G0S2 overexpression in the liver significantly improved glucose tolerance in mice. Livers expressing G0S2 exhibited increased 6-(N-(7-nitrobenz-2-oxa-1-3-diazol-4-yl amino-6-deoxyglucose uptake compared with livers transfected with control adenovirus. Taken together, our results provide evidence supporting an important role for G0S2 as a regulator of triglyceride content in the liver and suggest that G0S2 may be a molecular target for the treatment of insulin resistance and other obesity-related metabolic disorders.

  3. Asymmetric Expansion of the Youngest Galactic Supernova Remnant G1.9+0.3

    Science.gov (United States)

    Borkowski, Kazimierz J.; Gwynne, Peter; Reynolds, Stephen P.; Green, David A.; Hwang, Una; Petre, Robert; Willett, Rebecca

    2017-03-01

    The youngest Galactic supernova remnant (SNR) G1.9+0.3, produced by a (probable) SN Ia that exploded ˜1900 CE, is strongly asymmetric at radio wavelengths, much brighter in the north, but bilaterally symmetric in X-rays. We present the results of X-ray expansion measurements that illuminate the origin of the radio asymmetry. We confirm the mean expansion rate (2011-2015) of 0.58% yr-1, but large spatial variations are present. Using the nonparametric “Demons” method, we measure the velocity field throughout the entire SNR, finding that motions vary by a factor of 5, from 0\\buildrel{\\prime\\prime}\\over{.} 09 to 0\\buildrel{\\prime\\prime}\\over{.} 44 yr-1. The slowest shocks are at the outer boundary of the bright northern radio rim, with velocities v s as low as 3600 km s-1 (for an assumed distance of 8.5 kpc), much less than v s = 12,000-13,000 km s-1 along the X-ray-bright major axis. Such strong deceleration of the northern blast wave most likely arises from the collision of SN ejecta with a much denser than average ambient medium there. This asymmetric ambient medium naturally explains the radio asymmetry. In several locations, significant morphological changes and strongly nonradial motions are apparent. The spatially integrated X-ray flux continues to increase with time. Based on Chandra observations spanning 8.3 yr, we measure its increase at 1.3 % +/- 0.8 % yr-1. The SN ejecta are likely colliding with the asymmetric circumstellar medium ejected by the SN progenitor prior to its explosion.

  4. Implementing a High-Assurance Smart-Card OS

    Science.gov (United States)

    Karger, Paul A.; Toll, David C.; Palmer, Elaine R.; McIntosh, Suzanne K.; Weber, Samuel; Edwards, Jonathan W.

    Building a high-assurance, secure operating system for memory constrained systems, such as smart cards, introduces many challenges. The increasing power of smart cards has made their use feasible in applications such as electronic passports, military and public sector identification cards, and cell-phone based financial and entertainment applications. Such applications require a secure environment, which can only be provided with sufficient hardware and a secure operating system. We argue that smart cards pose additional security challenges when compared to traditional computer platforms. We discuss our design for a secure smart card operating system, named Caernarvon, and show that it addresses these challenges, which include secure application download, protection of cryptographic functions from malicious applications, resolution of covert channels, and assurance of both security and data integrity in the face of arbitrary power losses.

  5. A Comparison of Card-sorting Analysis Methods

    DEFF Research Database (Denmark)

    Nawaz, Ather

    2012-01-01

    This study investigates how the choice of analysis method for card sorting studies affects the suggested information structure for websites. In the card sorting technique, a variety of methods are used to analyse the resulting data. The analysis of card sorting data helps user experience (UX......) designers to discover the patterns in how users make classifications and thus to develop an optimal, user-centred website structure. During analysis, the recurrence of patterns of classification between users influences the resulting website structure. However, the algorithm used in the analysis influences...... the recurrent patterns found and thus has consequences for the resulting website design. This paper draws an attention to the choice of card sorting analysis and techniques and shows how it impacts the results. The research focuses on how the same data for card sorting can lead to different website structures...

  6. Mobile Broadcast DRM Based on User Identity Card

    Directory of Open Access Journals (Sweden)

    Byung-Rae Lee

    2007-11-01

    Full Text Available The current mobile broadcast systems do not provide efficient solution for consumption of service and content based on the user identity card such as a smartcard. This prevents users from consuming broadcast service and contents independent of a specific terminal (e.g., the one used for registration or purchase. To provide usage of broadcast services based on the user identity card, mutual authentication needs to be established among the service provider, the terminal, and the user identity card whenever the terminal is changed. The crucial element for this is assuring the service provider, the terminal, and the user identity card by authenticating each entity to the other entities. In this paper, we propose the new authentication scheme, which provides efficient scheme for three kinds of mutual authentications among the service provider, the terminal, and the user identity card. We also construct mobile broadcast DRM system based on the proposed authentication scheme for consumption of broadcast services with multiple terminals.

  7. Vulnerabilities in First-Generation RFID-enabled Credit Cards

    Science.gov (United States)

    Heydt-Benjamin, Thomas S.; Bailey, Daniel V.; Fu, Kevin; Juels, Ari; O'Hare, Tom

    RFID-enabled credit cards are widely deployed in the United States and other countries, but no public study has thoroughly analyzed the mechanisms that provide both security and privacy. Using samples from a variety of RFID-enabled credit cards, our study observes that (1) the cardholder's name and often credit card number and expiration are leaked in plaintext to unauthenticated readers, (2) our homemade device costing around 150 effectively clones one type of skimmed cards thus providing a proof-of-concept implementation for the RF replay attack, (3) information revealed by the RFID transmission cross contaminates the security of RFID and non-RFID payment contexts, and (4) RFID-enabled credit cards are susceptible in various degrees to a range of other traditional RFID attacks such as skimming and relaying.

  8. Comparison of fixation disparity measured by saladin card and disparometer.

    Science.gov (United States)

    Frantz, Kelly A; Elston, Phillip; Michalik, Emily; Templeman, Carrah D; Zoltoski, Rebecca K

    2011-06-01

    The purpose of this study was to compare the fixation disparity (FD) measurements taken with the Saladin Near Point Balance Card (Saladin card) to those made with the Sheedy Disparometer, and to determine if the same clinical norms used with the Disparometer can be applied to the newer Saladin card. Subjects were 44 optometry students (aged 23 to 34 years) without strabismus, amblyopia, or asthenopia during near work. They were randomized to begin at one of three examiners' stations: dissociated near phoria using Modified Thorington card; FD with Saladin card; and FD with Disparometer. Subjects proceeded to each station in turn. FD was measured for each subject through forced vergence demands of 0, 3, 6, and 9 base-in (BI), and 3, 6, 9, 16, and 20 base-out (BO), alternating BI and BO demands. Examiners were masked to subjects' results from the other stations. FD curve (FDC) types were the same with the two instruments in most cases. However, statistically significant differences were found for FDC slopes (p = 0.048), y intercepts (p Saladin card. FD values through BO prisms showed no statistically significant differences but great variability. The two instruments generally produce similar types of FDCs. However, the Disparometer tends to yield more eso/less exo FD measurements compared with the Saladin card. Although the newer Saladin card frequently produces FDC slopes and y intercepts within the expected range (as published for the Disparometer) for asymptomatic subjects, slopes and y intercepts obtained by the Saladin card are not sufficiently similar to those obtained by the Disparometer to warrant use of the same norms. Further study is needed to establish appropriate norms for the Saladin card.

  9. Maxed out: The Relationship between Credit Card Debt, Credit Card Distress and Grade Point Averages for College Students

    Science.gov (United States)

    Smith, Temple Day

    2011-01-01

    Few students leave college with a plan for paying off their debt. Starting a career inundated with student loans and credit card debt burdens is a reality many college students face today. In the wake of graduation coming to terms with the consequences of credit card debt is stressful for many students. This dissertation observes the relationship…

  10. Study of interactions between odorant molecules and the hOR1G1 olfactory receptor by molecular modeling

    Directory of Open Access Journals (Sweden)

    Assia Belhassan

    2017-11-01

    Full Text Available In order to initiate the process of determining how the molecular level receptor-odorant interactions are related to odor perception, we used the SWISS-MODEL modeling server to predict the three dimensional (3D structure of the human olfactory receptor (hOR1G1. The model was refined using minimization and side-chain optimization using SCWRL. We then used the Autodockvina and Autodock tools to predict the binding site and binding energy for the library of 13 odorants characterized by different retention/release property values to hOR1G1 receptor, to investigate the relationship between this property and the ligand-hOR1G1 interactions. We find that when the retention property increases, hydrogen bond interactions between ligands and olfactory receptor (hOR1G1 become favorable.

  11. Final COMPASS results on the deuteron spin-dependent structure function g1d and the Bjorken sum rule

    Directory of Open Access Journals (Sweden)

    C. Adolph

    2017-06-01

    Full Text Available Final results are presented from the inclusive measurement of deep-inelastic polarised-muon scattering on longitudinally polarised deuterons using a 6LiD target. The data were taken at 160 GeV beam energy and the results are shown for the kinematic range 1(GeV/c24GeV/c2 in the mass of the hadronic final state. The deuteron double-spin asymmetry A1d and the deuteron longitudinal-spin structure function g1d are presented in bins of x and Q2. Towards lowest accessible values of x, g1d decreases and becomes consistent with zero within uncertainties. The presented final g1d values together with the recently published final g1p values of COMPASS are used to again evaluate the Bjorken sum rule and perform the QCD fit to the g1 world data at next-to-leading order of the strong coupling constant. In both cases, changes in central values of the resulting numbers are well within statistical uncertainties. The flavour-singlet axial charge a0, which is identified in the MS‾ renormalisation scheme with the total contribution of quark helicities to the nucleon spin, is extracted at next-to-leading order accuracy from only the COMPASS deuteron data: a0(Q2=3(GeV/c2=0.32±0.02stat±0.04syst±0.05evol. Together with the recent results on the proton spin structure function g1p, the results on g1d constitute the COMPASS legacy on the measurements of g1 through inclusive spin-dependent deep inelastic scattering.

  12. Evaluation of NK cell level and HLA-G1 expression in peripheral blood in threatened-abortion

    Directory of Open Access Journals (Sweden)

    Saeideh Sadat Shobeiri

    2015-05-01

    Conclusion: Decreasing of human leukocyte antigen-G1 expression with increasing of natural killer cells level in threatened-abortion pregnant women is an indicator of mother's immune system dysregulation in comparison with control group. Therefore, it is concluded that in the threatened-abortion pregnant women, human leukocyte antigen-G1 expression level with natural killer cells percent as diagnostic marker must be determine.

  13. THE COMPARATIVE ANALYSIS OF CARDS ISSUED IN ROMANIA. THE ELECTRONIC PAYMENTS BASED ON THE VISA CARD

    Directory of Open Access Journals (Sweden)

    DUDUIALĂ POPESCU LORENA

    2017-11-01

    Full Text Available The electronic payments are a significant invention of sec. XXI, on the background of the development of telecommunications information technology in Romania. The spread of computers, public, fast and cheap telecoms, large-scale networks, and the Internet have created national, regional and global infrastructure, the current electronic payment systems, electronic money transfers and today's infrastructure of developed and developing economies. The electronic payment systems are the most dynamic part of the computerized, digital, local, regional and global economy. The components of the systems are card payment systems, e-commerce, and interbank and inter-company electronic transfers, with Visa and MasterCard telecommunication networks, the Internet and the SWIFT network.

  14. Endothelial ATP-binding cassette G1 in mouse endothelium protects against hemodynamic-induced atherosclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Xue, Shanshan [Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070 (China); Department of Pediatrics, Baodi District People’s Hospital of Tianjin City, Tianjin, 301800 (China); Wang, Jiaxing [Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, 100191 (China); Zhang, Xu; Shi, Ying; Li, Bochuan; Bao, Qiankun [Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070 (China); Pang, Wei [Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, 100191 (China); Ai, Ding [Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070 (China); Zhu, Yi [Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070 (China); Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, 100191 (China); He, Jinlong, E-mail: hejinlong@tmu.edu.cn [Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070 (China)

    2016-08-19

    Activated vascular endothelium inflammation under persistent hyperlipidemia is the initial step of atherogenesis. ATP-binding cassette G1 (ABCG1) is a crucial factor maintaining sterol and lipid homeostasis by transporting cholesterol efflux to high-density lipoprotein. In this study, we investigated the protective effects of ABCG1 in endothelial inflammation activation during early-stage atherogenesis in mice and the underlying mechanisms. Endothelial cell (EC)-specific ABCG1 transgenic (EC-ABCG1-Tg) mice were generated and cross-bred with low-density lipoprotein receptor–deficient (Ldlr{sup −/−}) mice. After a 4-week Western-type diet, the mice were sacrificed for assessing atherosclerosis. Human umbilical vein ECs were treated with different flows, and ABCG1 was adenovirally overexpressed to investigate the mechanism in vitro. Compared with Ldlr{sup −/−} mouse aortas, EC-ABCG1-Tg/Ldlr{sup −/−} aortas showed decreased early-stage lesions. Furthermore, the lesion area in the EC-ABCG1-Tg/Ldlr{sup −/−} mouse aortic arch but not thoracic aorta was significantly reduced, which suggests a protective role of ABCG1 under atheroprone flow. In vitro, overexpression of ABCG1 attenuated EC activation caused by oscillatory shear stress. Overexpression of ABCG1 blunted cholesterol-activated ECs in vitro. In exploring the mechanisms of ABCG1 attenuating endothelial inflammation, we found that ABCG1 inhibited oscillatory flow-activated nuclear factor kappa B and NLRP3 inflammasome in ECs. ABCG1 may play a protective role in early-stage atherosclerosis by reducing endothelial activation induced by oscillatory shear stress via suppressing the inflammatory response. - Highlights: • EC-ABCG1-Tg mice in a Ldlr{sup −/−} background showed decreased atherosclerosis. • Overexpression of ABCG1 in ECs decreased OSS-induced EC activation. • NLRP3 and NF-κB might be an underlying mechanism of ABCG1 protective role.

  15. FACT prevents the accumulation of free histones evicted from transcribed chromatin and a subsequent cell cycle delay in G1.

    Directory of Open Access Journals (Sweden)

    Macarena Morillo-Huesca

    2010-05-01

    Full Text Available The FACT complex participates in chromatin assembly and disassembly during transcription elongation. The yeast mutants affected in the SPT16 gene, which encodes one of the FACT subunits, alter the expression of G1 cyclins and exhibit defects in the G1/S transition. Here we show that the dysfunction of chromatin reassembly factors, like FACT or Spt6, down-regulates the expression of the gene encoding the cyclin that modulates the G1 length (CLN3 in START by specifically triggering the repression of its promoter. The G1 delay undergone by spt16 mutants is not mediated by the DNA-damage checkpoint, although the mutation of RAD53, which is otherwise involved in histone degradation, enhances the cell-cycle defects of spt16-197. We reveal how FACT dysfunction triggers an accumulation of free histones evicted from transcribed chromatin. This accumulation is enhanced in a rad53 background and leads to a delay in G1. Consistently, we show that the overexpression of histones in wild-type cells down-regulates CLN3 in START and causes a delay in G1. Our work shows that chromatin reassembly factors are essential players in controlling the free histones potentially released from transcribed chromatin and describes a new cell cycle phenomenon that allows cells to respond to excess histones before starting DNA replication.

  16. The ProCard mobile banking system

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available The mobile banking involves the use of some mobile telecommunication devices (such phones or PDAs - Personal Digital Assistants in order to complete, in a secure manner, banking transactions (like payments, transfers, account information and so on. It doesn't matter where the user is physically located. Also, the hour when the services are requested is not important anymore, because, thanks to the internet banking, the offices are virtually opened 24 hours per day. The ProCard system represents a suite of applications used to perform mobile banking. It was intended to be a universal solution that allows EFT, Internet and mobile banking in a single package. No special software or hardware is required

  17. Authentications of Myanmar National Registration Card

    Directory of Open Access Journals (Sweden)

    Myint Myint Sein

    2013-04-01

    Full Text Available The automatic identification system of Myanmar national registration card (NRC holder is presented in this paper. The proposed system can be handled the identification by the extracted low quality face image and fingerprint image from Myanmar NRC. Both of the facial recognition and fingerprint recognition system are developed for Myanmar citizenship confirmation. Age invariant face recognition algorithm is performed based on combination of DiaPCA (Diagonal principal Component Analysis and KNN (Kth nearest neighbor classifier approaches. An algorithm of the fingerprint recognition is proposed for recognition of the poor quality fingerprint image with fabric background.  Several experiments have been done for confirming the effectiveness of the proposed approach.

  18. The Security Email Based on Smart Card

    Science.gov (United States)

    Lina, Zhang; Jiang, Meng Hai.

    Email has become one of the most important communication tools in modern internet society, and its security is an important issue that can't be ignored. The security requirements of Email can be summarized as confidentiality, integrity, authentication and non-repudiation. Recently many researches on IBE (identify based encrypt) have been carried out to solve these security problems. However, because of IBE's fatal flaws and great advantages of PKI (Public Key Infrastructure), PKI is found to be still irreplaceable especially in the applications based on smart card. In this paper, a construction of security Email is presented, then the design of relatively cryptography algorithms and the configuration of certificates are elaborated, and finally the security for the proposed system is discussed.

  19. A stack of cards rebuilt with calculus

    Science.gov (United States)

    Kazachkov, Alexander; Kireš, Marián

    2017-07-01

    Previous work covers building a tower from a stack of homogeneous rectangular plates, each with a maximum shift in displacement. We suggest using plates shaped as curvilinear triangles bounded by segments of power-law functions. The masses of the plates and the position of their center of mass are calculated and measured experimentally after cutting them out from cardboard and aluminum sheets. A computer simulation of the displacement towers is combined with their live building. Individual maximum shifts of the plates in the stack prove to be much bigger the higher the power coefficient of the boundary curves. The resulting total overhang of such a displacement tower may exceed that of a stack of traditionally used homogeneous rectangular cards.

  20. VizItCards: A Card-Based Toolkit for Infovis Design Education.

    Science.gov (United States)

    He, Shiqing; Adar, Eytan

    2017-01-01

    Shifts in information visualization practice are forcing a reconsideration of how infovis is taught. Traditional curricula that focused on conveying research-derived knowledge are slowly integrating design thinking as a key learning objective. In part, this is motivated by the realization that infovis is a wicked design problem, requiring a different kind of design work. In this paper we describe, VizItCards, a card-driven workshop developed for our graduate infovis class. The workshop is intended to provide practice with good design techniques and to simultaneously reinforce key concepts. VizItCards relies on principles of collaborative-learning and research on parallel design to generate positive collaborations and high-quality designs. From our experience of simulating a realistic design scenario in a classroom setting, we find that our students were able to meet key learning objectives and their design performance improved during the class. We describe variants of the workshop, discussing which techniques we think match to which learning goals.

  1. Comparison of fixation disparity curve parameters obtained with the Wesson and Saladin fixation disparity cards.

    Science.gov (United States)

    Ngan, Janice; Goss, David A; Despirito, Joseph

    2005-01-01

    This study compared fixation curve parameters with two commercially available fixation disparity cards, one that has been available for several years, the Wesson card, and a new one, the Saladin card. Fixation disparity curves were measured on 50 subjects with the Wesson fixation disparity card and the Saladin fixation disparity card. The x intercepts were on average more in the base-in direction with the Wesson card than with the Saladin card. The y intercepts were shifted in the exo direction with the Wesson card compared with the Saladin card. The slope with the Wesson card was steeper than the slope obtained with the Saladin card. The distribution of curve types was also different with the two different instruments. Fixation disparity curves measured with these two instruments are different, and separate norms should be used for each fixation disparity measurement method.

  2. Divergence of VP7 genes of G1 rotaviruses isolated from infants vaccinated with reassortant rhesus rotaviruses.

    Science.gov (United States)

    Jin, Q; Ward, R L; Knowlton, D R; Gabbay, Y B; Linhares, A C; Rappaport, R; Woods, P A; Glass, R I; Gentsch, J R

    1996-01-01

    A large placebo-controlled efficacy trial of the rhesus tetravalent (RRV-TV) and serotype G1 monovalent (RRV-S1) rotavirus vaccines was conducted in 1991-1992 at 24 sites across the United States. Protection was 49% and 54% against all diarrhea but 80% and 69% against very severe gastroenteritis for the two vaccines, respectively. Post-vaccination neutralizing antibody titers to the G1 Wa strain, whose VP7 protein is nearly identical to that of the D strain of rotavirus contained in both vaccines, did not correlate with protection against subsequent illness with G1 strains. This result raised the possibility that in infants who developed post-vaccination neutralizing antibody to Wa, breakthrough (i.e., vaccine failure-the occurrence of rotavirus diarrhea after immunization) may have been due to infection by G1 strains that were sufficiently antigenically distinct from the vaccine strain to evade the neutralizing antibodies elicited by vaccination. To test this hypothesis, we initially compared post-vaccination neutralizing antibody titers of vaccinees against Wa and G1 breakthrough strains using sera from subjects who experienced breakthrough. Post-immunization neutralizing antibody titers to Wa elicited by vaccination were significantly (P correlate with lack of protection since similar differences in titer to Wa and breakthrough strains were found using post-vaccination sera from vaccinees who either experienced asymptomatic rotavirus infections or no infections. To determine the genetic basis for these differences, we compared the VP7 gene sequences of Wa with vaccine strain D, 12 G1 breakthrough strains, and 3 G1 control strains isolated during the same trial from placebo recipients. All breakthrough strains were distinct from Wa and D in antigenically important regions throughout the VP7 protein, but these differences were conserved between breakthrough and placebo strains. Furthermore, a comparative analysis of the deduced amino sequences form VP7 genes of G1

  3. Credit Card Risk Behavior on College Campuses: Evidence from Brazil

    Directory of Open Access Journals (Sweden)

    Wesley Mendes-da-Silva

    2012-07-01

    Full Text Available College students frequently show they have little skill when it comes to using a credit card in a responsible manner. This article deals with this issue in an emerging market and in a pioneering manner. University students (n = 769 in São Paulo, Brazil’s main financial center, replied to a questionnaire about their credit card use habits. Using Logit models, associations were discovered between personal characteristics and credit card use habits that involve financially risky behavior. The main results were: (a a larger number of credit cards increases the probability of risky behavior; (b students who alleged they knew what interest rates the card administrators were charging were less inclined to engage in risky behavior. The results are of interest to the financial industry, to university managers and to policy makers. This article points to the advisability, indeed necessity, of providing students with information about the use of financial products (notably credit cards bearing in mind the high interest rates which their users are charged. The findings regarding student behavior in the use of credit cards in emerging economies are both significant and relevant. Furthermore, financial literature, while recognizing the importance of the topic, has not significantly examined the phenomenon in emerging economies.

  4. Relação entre imagem adrenérgica cardíaca e teste ergométrico na insuficiência cardíaca Relación entre imagen adrenérgica cardíaca y ergometría en la insuficiencia cardíaca Relationship between cardiac adrenergic image and exercise testing in heart failure

    Directory of Open Access Journals (Sweden)

    Leandro Rocha Messias

    2011-05-01

    Full Text Available FUNDAMENTO: Na insuficiência cardíaca, o teste ergométrico (TE avalia capacidade funcional, um determinante de prognóstico. A cintilografia com I¹²³ MIBG mostra a ativação simpática cardíaca. OBJETIVO: Avaliar a associação entre as variáveis do TE e as alterações da cintilografia com I¹²³ MIBG. MÉTODOS: Foram submetidos 23 pacientes (FEVE 27%. Esses pacientes realizaram TE, onde foram analisadas: pressão arterial sistólica no pico do esforço (PASP, frequência cardíaca no pico do esforço (FCP, variação da pressão arterial sistólica intraesforço (Δ PAS, reserva cronotrópica e capacidade funcional em METs. Utilizaram-se para a análise estatística, o teste t de Student ou o teste U de Mann-Whitney, o coeficiente de Spearman e o coeficiente de regressão linear. RESULTADOS: A PASP (G1: 181,00 ± 28,01; G2: 153,27 ± 27,71, p = 0,027, a Δ PAS [G1: 64 (47,5-80,5; G2: 36 (25-47 mmHg, p = 0,015], a FCP (G1: 136,91 ± 19,66; G2: 118,45 ± 13,98 bpm, p = 0,018, a reserva cronotrópica (G1: 70,42 ± 17,94; G2: 49,47 ± 14,89%, p = 0,006 e a capacidade funcional [G1: 8,37 (6,47-10,27; G2: 4,42 (2,46-6,38 METs, p = 0,003] foram menores no G2. Houve correlação negativa entre taxa de Washout com PASP (r = -0,505, p = 0,014, Δ PAS (r = -0,493, p = 0,017 e capacidade funcional (r = -0,646, p = 0,001. Após regressão linear, PASP (r = -0,422, p = 0,016 e capacidade funcional (r = -0,804, p = 0,004 foram associadas com taxa de Washout. CONCLUSÃO: Em pacientes com insuficiência cardíaca, PASP e capacidade funcional foram as varáveis mais associadas com a taxa de Washout.FUNDAMENTOS: En la Insuficiencia Cardíaca, la Ergometría (Test Ergométrico - TE evalúa la capacidad funcional, un determinante de pronóstico. El centellograma con I¹²³ MIBG muestra la activación simpática cardíaca. OBJETIVO: Evaluar la asociación entre las variables del TE y las alteraciones del centellograma con I¹²³ MIBG. MÉTODOS: Se

  5. SISTEM TERPADU REKAM MEDIK RUMAH SAKIT DENGAN SMART CARD

    Directory of Open Access Journals (Sweden)

    _ Sukamto

    2012-01-01

    Full Text Available Dalam penelitian ini, system terpadu rekam medik rumah sakit dibuat dengan teknologi smart card sebagai media penimpanan data Tujuan dari penelitian ini adalah menerapkan teknologi smart card sebagai sarana atau media penyimpan informasi pasien yang mempunyai kesederhana, keandalan, dan portabilitas yang tinggi, sehingga meningkatkan jaminan ketersediaan data pada sebuah sistem rekam medik.Tahapan pembuatan rancang bangun sistem rekam medis ini meliputi perancangan data flow diagram, rentity relationshipp diagram, database dan program aplikasi. Hasil dari penelitian ini menunjukan bahwa smart card dapat digunakan sebagai sarana atau media penyimpan informasi pasien yang mempunyai kesederhana, keandalan, dan portabilitas yang tinggi.

  6. REMINDER PERIOD OF VALIDITY OF CERN (ACCESS) CARDS

    CERN Multimedia

    Relations with the Host States Service

    2002-01-01

    The period of validity of CERN (access) cards not bearing an expiry date has been extended from 30 June to 31 December 2002 (see paragraph 17.4 of the Implementation Measures relating to Operational Circular n° 2). Holders of such cards are kindly requested to have their cards renewed either at the Users Office (in the case of Users) or at the Registration Service (all the others) from 1 August 2002 onwards. Relations with the Host States Service http://www.cern.ch/relations/ Tel. 72848

  7. REMINDER PERIOD OF VALIDITY OF CERN (ACCESS) CARDS

    CERN Multimedia

    Relations with the Host States Service

    2002-01-01

    The period of validity of CERN (access) cards not bearing an expiry date has been extended from 30 June to 31 December 2002 (see paragraph 17.4 of the Implementation Measures relating to Operational Circular n° 2). Holders of such cards are kindly requested to have their cards renewed either at the Users Office (in the case of Users) or at the Registration Service (all the others) from 1 August 2002 onwards.Relations with the Host States Service Tel. 72848

  8. REMINDER - PERIOD OF VALIDITY OF CERN (ACCESS) CARDS

    CERN Multimedia

    Relations with the Host States Service

    2003-01-01

    The period of validity of CERN (access) cards not bearing an expiry date has been extended from 30 June to 31 December 2002 (see paragraph 17.4 of the Implementation Measures relating to Operational Circular n° 2). Holders of such cards are kindly requested to have their cards renewed either at the Users Office (in the case of Users) or at the Registration Service (all the others) from 1 August 2002 onwards. Relations with the Host States Service http://www.cern.ch/relations/ Tel. 72848

  9. Mated Fingerprint Card Pairs (Volumes 1-5)

    Science.gov (United States)

    NIST Mated Fingerprint Card Pairs (Volumes 1-5) (Web, free access)   The NIST database of mated fingerprint card pairs (Special Database 9) consists of multiple volumes. Currently five volumes have been released. Each volume will be a 3-disk set with each CD-ROM containing 90 mated card pairs of segmented 8-bit gray scale fingerprint images (900 fingerprint image pairs per CD-ROM). A newer version of the compression/decompression software on the CDROM can be found at the website http://www.nist.gov/itl/iad/ig/nigos.cfm as part of the NBIS package.

  10. The Cold Dark Matter Search test stand warm electronics card

    Energy Technology Data Exchange (ETDEWEB)

    Hines, Bruce; /Colorado U., Denver; Hansen, Sten; /Fermilab; Huber, Martin; /Colorado U., Denver; Kiper, Terry; /Fermilab; Rau, Wolfgang; /Queen' s U., Kingston; Saab, Tarek; /Florida U.; Seitz, Dennis; Sundqvist, Kyle; /UC, Berkeley; Mandic, Vuk; /Minnesota U.

    2010-11-01

    A card which does the signal processing for four SQUID amplifiers and two charge sensitive channels is described. The card performs the same functions as is presently done with two custom 9U x 280mm Eurocard modules, a commercial multi-channel VME digitizer, a PCI to GPIB interface, a PCI to VME interface and a custom built linear power supply. By integrating these functions onto a single card and using the power over Ethernet standard, the infrastructure requirements for instrumenting a Cold Dark Matter Search (CDMS) detector test stand are significantly reduced.

  11. Indian Kisan Credit Card Scheme: An Analytical Study

    Directory of Open Access Journals (Sweden)

    Dharmendra Mehta

    2016-03-01

    Full Text Available Kisan Credit Card (KCC has now been regarded as the only medium of short-term credit for agriculture. The Kisan Credit Card (KCC scheme was introduced by the Finance Minister in his budget speech in the year 1998-99. From the year 1998-99, the scheme was implemented by public sector commercial banks, RRBs (Regional Rural Banks and cooperative banks in the country. It has emerged as an innovative credit distribution system to meet the production credit requirements of the farmers in a timely and easy manner. The present paper is aimed to study role of Kisan Credit Card in the rural credit facilitation in India.

  12. Analisis SIM Card Cloning Terhadap Algoritma Random Number Generator

    OpenAIRE

    Anwar, Nuril; Riadi, Imam; Luthfi, Ahmad

    2016-01-01

    . Crime in telecommunication sector has increased prevalently, especially with the use of mobile phone which is detrimental both for customers and the providers. In the GSM security system, several weaknesses are found concerning data security outside the network. SIM card clone is part of the security problem in which the data can be transferred to SIM card cloning media. SIM card cloning research can be presented in the form of SRES analysis algorithms A3 and A8 RAND to get Ki Auc for furth...

  13. Identification of Clusters in Travel Patterns using Smart Card Data

    DEFF Research Database (Denmark)

    Reinau, Kristian Hegner; Harder, Henrik

    2016-01-01

    This article is the first contribution, which explores the potential of smart card data in relation to optimization of public transport in a peripheral monocentric region. A modularity analysis is made using smart card data collected in Northern Jutland in Marts and July 2014, and the analysis...... reveals first, that smart card data can be used to identify clusters within flows of public transport passengers in a peripheral region. Second, that the presence of such clusters suggest that public transport should be planned to give the users the possibility of travelling with good connectivity...

  14. Copy number variation and transposable elements feature in recent, ongoing adaptation at the Cyp6g1 locus.

    Science.gov (United States)

    Schmidt, Joshua M; Good, Robert T; Appleton, Belinda; Sherrard, Jayne; Raymant, Greta C; Bogwitz, Michael R; Martin, Jon; Daborn, Phillip J; Goddard, Mike E; Batterham, Philip; Robin, Charles

    2010-06-24

    The increased transcription of the Cyp6g1 gene of Drosophila melanogaster, and consequent resistance to insecticides such as DDT, is a widely cited example of adaptation mediated by cis-regulatory change. A fragment of an Accord transposable element inserted upstream of the Cyp6g1 gene is causally associated with resistance and has spread to high frequencies in populations around the world since the 1940s. Here we report the existence of a natural allelic series at this locus of D. melanogaster, involving copy number variation of Cyp6g1, and two additional transposable element insertions (a P and an HMS-Beagle). We provide evidence that this genetic variation underpins phenotypic variation, as the more derived the allele, the greater the level of DDT resistance. Tracking the spatial and temporal patterns of allele frequency changes indicates that the multiple steps of the allelic series are adaptive. Further, a DDT association study shows that the most resistant allele, Cyp6g1-[BP], is greatly enriched in the top 5% of the phenotypic distribution and accounts for approximately 16% of the underlying phenotypic variation in resistance to DDT. In contrast, copy number variation for another candidate resistance gene, Cyp12d1, is not associated with resistance. Thus the Cyp6g1 locus is a major contributor to DDT resistance in field populations, and evolution at this locus features multiple adaptive steps occurring in rapid succession.

  15. Copy number variation and transposable elements feature in recent, ongoing adaptation at the Cyp6g1 locus.

    Directory of Open Access Journals (Sweden)

    Joshua M Schmidt

    2010-06-01

    Full Text Available The increased transcription of the Cyp6g1 gene of Drosophila melanogaster, and consequent resistance to insecticides such as DDT, is a widely cited example of adaptation mediated by cis-regulatory change. A fragment of an Accord transposable element inserted upstream of the Cyp6g1 gene is causally associated with resistance and has spread to high frequencies in populations around the world since the 1940s. Here we report the existence of a natural allelic series at this locus of D. melanogaster, involving copy number variation of Cyp6g1, and two additional transposable element insertions (a P and an HMS-Beagle. We provide evidence that this genetic variation underpins phenotypic variation, as the more derived the allele, the greater the level of DDT resistance. Tracking the spatial and temporal patterns of allele frequency changes indicates that the multiple steps of the allelic series are adaptive. Further, a DDT association study shows that the most resistant allele, Cyp6g1-[BP], is greatly enriched in the top 5% of the phenotypic distribution and accounts for approximately 16% of the underlying phenotypic variation in resistance to DDT. In contrast, copy number variation for another candidate resistance gene, Cyp12d1, is not associated with resistance. Thus the Cyp6g1 locus is a major contributor to DDT resistance in field populations, and evolution at this locus features multiple adaptive steps occurring in rapid succession.

  16. Therapeutic application of human leukocyte antigen-G1 improves atopic dermatitis-like skin lesions in mice.

    Science.gov (United States)

    Maeda, Naoyoshi; Yamada, Chisato; Takahashi, Ami; Kuroki, Kimiko; Maenaka, Katsumi

    2017-09-01

    Human leukocyte antigen (HLA)-G is an immune checkpoint molecule that plays critical roles in immune response and in triggering inhibitory signaling to immune cells such as T cells, natural killer cells, and antigen-presenting cells. Thus, the application of HLA-G can be considered for treating immune response-related inflammatory disorders. We have previously reported that treatment with HLA-G1 and HLA-G2 ameliorates the joint swelling associated with collagen-induced arthritis of DBA/1 mice, an animal model for rheumatoid arthritis. In this study, we further investigated the effects of HLA-G1 on atopic dermatitis (AD), the most common inflammatory skin disorder. AD-like lesions were induced with the extract of the house dust mite Dermatophagoides farinae in NC/Nga mice. Continuous administration of HLA-G1 ameliorated the AD-like skin lesions in the mice. Furthermore, production of immunoglobulin E, interleukin (IL)-13, and IL-17A was significantly reduced in HLA-G1-treated mice, suggesting a Th2/Th17-mediated immune-inhibitory function of HLA-G1 in vivo. Our studies shed light on novel therapeutic strategies with recombinant HLA-G proteins for immune reaction-mediated chronic inflammatory disorders. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. The spin structure function g1p of the proton and a test of the Bjorken sum rule

    Directory of Open Access Journals (Sweden)

    C. Adolph

    2016-02-01

    Full Text Available New results for the double spin asymmetry A1p and the proton longitudinal spin structure function g1p are presented. They were obtained by the COMPASS Collaboration using polarised 200 GeV muons scattered off a longitudinally polarised NH3 target. The data were collected in 2011 and complement those recorded in 2007 at 160 GeV, in particular at lower values of x. They improve the statistical precision of g1p(x by about a factor of two in the region x≲0.02. A next-to-leading order QCD fit to the g1 world data is performed. It leads to a new determination of the quark spin contribution to the nucleon spin, ΔΣ, ranging from 0.26 to 0.36, and to a re-evaluation of the first moment of g1p. The uncertainty of ΔΣ is mostly due to the large uncertainty in the present determinations of the gluon helicity distribution. A new evaluation of the Bjorken sum rule based on the COMPASS results for the non-singlet structure function g1NS(x,Q2 yields as ratio of the axial and vector coupling constants |gA/gV|=1.22±0.05 (stat.±0.10 (syst., which validates the sum rule to an accuracy of about 9%.

  18. The spin-dependent structure function $g_1(x)$ of the proton from polarized deep-inelastic muon scattering

    CERN Document Server

    Adeva, B; Arvidson, A; Badelek, B; Bardin, G; Baum, G; Berglund, P; Betev, L; Birsa, R; De Botton, N R; Bradamante, Franco; Bravar, A; Bressan, A; Bültmann, S; Burtin, E; Crabb, D; Cranshaw, J; Çuhadar-Dönszelmann, T; Dalla Torre, S; Van Dantzig, R; Derro, B R; Deshpande, A A; Dhawan, S K; Dulya, C M; Eichblatt, S; Fasching, D; Feinstein, F; Fernández, C; Forthmann, S; Frois, Bernard; Gallas, A; Garzón, J A; Gilly, H; Giorgi, M A; Görtz, S; Gracia, G; De Groot, N; Haft, K; Von Harrach, D; Hasegawa, T; Hautle, P; Hayashi, N; Heusch, C A; Horikawa, N; Hughes, V W; Igo, G; Ishimoto, S; Iwata, T; Kabuss, E M; Kageya, T; Karev, A G; Ketel, T; Kiryluk, J; Kiselev, Yu F; Krivokhizhin, V G; Kröger, W; Kukhtin, V V; Kurek, K; Kyynäräinen, J; Lamanna, M; Landgraf, U; Le Goff, J M; Lehár, F; de Lesquen, A; Lichtenstadt, J; Litmaath, M; Magnon, A; Mallot, G K; Marie, F; Martin, A; Martino, J; Matsuda, T; Mayes, B W; McCarthy, J S; Medved, K S; Meyer, W T; Van Middelkoop, G; Miller, D; Miyachi, Y; Mori, K; Moromisato, J H; Nassalski, J P; Naumann, Lutz; Niinikoski, T O; Oberski, J; Ogawa, A; Grosse-Perdekamp, M; Pereira, H; Perrot-Kunne, F; Peshekhonov, V D; Pinsky, L; Platchkov, S K; Pló, M; Pose, D; Postma, H; Pretz, J; Puntaferro, R; Rädel, G; Rijllart, A; Reicherz, G; Rodríguez, M; Rondio, Ewa; Roscherr, B; Sabo, I; Saborido, J; Sandacz, A; Savin, I A; Schiavon, R P; Schiller, A; Sichtermann, E P; Simeoni, F; Smirnov, G I; Staude, A; Steinmetz, A; Stiegler, U; Stuhrmann, H B; Szleper, M; Tessarotto, F; Thers, D; Tlaczala, W; Tripet, A; Ünel, G; Velasco, M; Vogt, J; Voss, Rüdiger; Whitten, C; Windmolders, R; Wislicki, W; Witzmann, A; Ylöstalo, J; Zanetti, A M; Zaremba, K

    1997-01-01

    We present a new measurement of the virtual photon proton asymmetry $A_1^{\\rm p}$ from deep inelastic scattering of polarized muons on polarized protons in the kinematic range $0.0008 1$ GeV$^{2}$. A perturbative QCD evolution in next-to-leading order is used to determine $g_1^{\\rm p}(x)$ at a constant $Q^2$. At $Q^{2} = 10$ GeV$^{2}$ we find, in the measured range, $\\int_{0.003}^{0.7} g_{1}^{\\rm p}(x){\\rm d}x = 0.139 \\pm 0.006~({\\rm stat})\\pm 0.008~({\\rm syst)} \\pm 0.006~({\\rm evol})$. The value of the first moment $\\Gamma_{1}^{\\rm p} = \\int_{0}^{1} g_{1}^{\\rm p}(x){\\rm d}x$ of $g_{1}^{\\rm p}$ depends on the approach used to describe the behaviour of $g_{1}^{\\rm p}$ at low $x$. We find that the Ellis-Jaffe sum rule is violated. With our published result for $\\Gamma_{1}^{\\rm d}$ we confirm the Bjorken sum rule with an accuracy of $\\approx 15\\%$ at the one standard deviation level.

  19. The Spin Structure Function $g_1^{\\rm p}$ of the Proton and a Test of the Bjorken Sum Rule

    CERN Document Server

    Adolph, C.; Alexeev, M.G.; Alexeev, G.D.; Amoroso, A.; Andrieux, V.; Anosov, V.; Austregesilo, A.; Azevedo, C.; Badelek, B.; Balestra, F.; Barth, J.; Baum, G.; Beck, R.; Bedfer, Y.; Bernhard, J.; Bicker, K.; Bielert, E.R.; Birsa, R.; Bisplinghoff, J.; Bodlak, M.; Boer, M.; Bordalo, P.; Bradamante, F.; Braun, C.; Bressan, A.; Buchele, M.; Burtin, E.; Capozza, L.; Chang, W.C.; Chiosso, M.; Choi, I.; Chung, S.U.; Cicuttin, A.; Crespo, M.L.; Curiel, Q.; Dalla Torre, S.; Dasgupta, S.S.; Dasgupta, S.; Denisov, O.Yu.; Dhara, L.; Donskov, S.V.; Doshita, N.; Duic, V.; Dziewiecki, M.; Efremov, A.; Eversheim, P.D.; Eyrich, W.; Ferrero, A.; Finger, M.; M. Finger jr; Fischer, H.; Franco, C.; von Hohenesche, N. du Fresne; Friedrich, J.M.; Frolov, V.; Fuchey, E.; Gautheron, F.; Gavrichtchouk, O.P.; Gerassimov, S.; Giordano, F.; Gnesi, I.; Gorzellik, M.; Grabmuller, S.; Grasso, A.; Grosse-Perdekamp, M.; Grube, B.; Grussenmeyer, T.; Guskov, A.; Haas, F.; Hahne, D.; von Harrach, D.; Hashimoto, R.; Heinsius, F.H.; Herrmann, F.; Hinterberger, F.; Horikawa, N.; d'Hose, N.; Hsieh, C.Yu; Huber, S.; Ishimoto, S.; Ivanov, A.; Ivanshin, Yu.; Iwata, T.; Jahn, R.; Jary, V.; Jorg, P.; Joosten, R.; Kabuss, E.; Ketzer, B.; Khaustov, G.V.; Khokhlov, Yu. A.; Kisselev, Yu.; Klein, F.; Klimaszewski, K.; Koivuniemi, J.H.; Kolosov, V.N.; Kondo, K.; Konigsmann, K.; Konorov, I.; Konstantinov, V.F.; Kotzinian, A.M.; Kouznetsov, O.; Kramer, M.; Kremser, P.; Krinner, F.; Kroumchtein, Z.V.; Kuchinski, N.; Kunne, F.; Kurek, K.; Kurjata, R.P.; Lednev, A.A.; Lehmann, A.; Levillain, M.; Levorato, S.; Lichtenstadt, J.; Longo, R.; Maggiora, A.; Magnon, A.; Makins, N.; Makke, N.; Mallot, G.K.; Marchand, C.; Martin, A.; Marzec, J.; Matousek, J.; Matsuda, H.; Matsuda, T.; Meshcheryakov, G.; Meyer, W.; Michigami, T.; Mikhailov, Yu. V.; Miyachi, Y.; Nagaytsev, A.; Nagel, T.; Nerling, F.; Neyret, D.; Nikolaenko, V.I.; Novy, J.; Nowak, W.D.; Nunes, A.S.; Olshevsky, A.G.; Orlov, I.; Ostrick, M.; Panzieri, D.; Parsamyan, B.; Paul, S.; Peng, J.C.; Pereira, F.; Pesek, M.; Peshekhonov, D.V.; Platchkov, S.; Pochodzalla, J.; Polyakov, V.A.; Pretz, J.; Quaresma, M.; Quintans, C.; Ramos, S.; Regali, C.; Reicherz, G.; Riedl, C.; Rocco, E.; Rossiyskaya, N.S.; Ryabchikov, D.I.; Rychter, A.; Samoylenko, V.D.; Sandacz, A.; Santos, C.; Sarkar, S.; Savin, I.A.; Sbrizzai, G.; Schiavon, P.; Schmidt, K.; Schmieden, H.; Schonning, K.; Schopferer, S.; Selyunin, A.; Shevchenko, O.Yu.; Silva, L.; Sinha, L.; Sirtl, S.; Slunecka, M.; Sozzi, F.; Srnka, A.; Stolarski, M.; Sulc, M.; Suzuki, H.; Szabelski, A.; Szameitat, T.; Sznajder, P.; Takekawa, S.; Wolbeek, J. ter; Tessaro, S.; Tessarotto, F.; Thibaud, F.; Tosello, F.; Tskhay, V.; Uhl, S.; Veloso, J.; Virius, M.; Weisrock, T.; Wilfert, M.; Windmolders, R.; Zaremba, K.; Zavertyaev, M.; Zemlyanichkina, E.; Ziembicki, M.; Zink, A.

    2016-02-10

    New results for the double spin asymmetry $A_1^{\\rm p}$ and the proton longitudinal spin structure function $g_1^{\\rm p}$ are presented. They were obtained by the COMPASS collaboration using polarised 200 GeV muons scattered off a longitudinally polarised NH$_3$ target. The data were collected in 2011 and complement those recorded in 2007 at 160\\,GeV, in particular at lower values of $x$. They improve the statistical precision of $g_1^{\\rm p}(x)$ by about a factor of two in the region $x\\lesssim 0.02$. A next-to-leading order QCD fit to the $g_1$ world data is performed. It leads to a new determination of the quark spin contribution to the nucleon spin, $\\Delta \\Sigma$ ranging from 0.26 to 0.36, and to a re-evaluation of the first moment of $g_1^{\\rm p}$. The uncertainty of $\\Delta \\Sigma$ is mostly due to the large uncertainty in the present determinations of the gluon helicity distribution. A new evaluation of the Bjorken sum rule based on the COMPASS results for the non-singlet structure function $g_1^{\\rm...

  20. Molecular Dynamics Simulation of the Crystallizable Fragment of IgG1—Insights for the Design of Fcabs

    Science.gov (United States)

    Lai, Balder; Hasenhindl, Christoph; Obinger, Christian; Oostenbrink, Chris

    2014-01-01

    An interesting format in the development of therapeutic monoclonal antibodies uses the crystallizable fragment of IgG1 as starting scaffold. Engineering of its structural loops allows generation of an antigen binding site. However, this might impair the molecule’s conformational stability, which can be overcome by introducing stabilizing point mutations in the CH3 domains. These point mutations often affect the stability and unfolding behavior of both the CH2 and CH3 domains. In order to understand this cross-talk, molecular dynamics simulations of the domains of the Fc fragment of human IgG1 are reported. The structure of human IgG1-Fc obtained from X-ray crystallography is used as a starting point for simulations of the wild-type protein at two different pH values. The stabilizing effect of a single point mutation in the CH3 domain as well as the impact of the hinge region and the glycan tree structure connected to the CH2 domains is investigated. Regions of high local flexibility were identified as potential sites for engineering antigen binding sites. Obtained data are discussed with respect to the available X-ray structure of IgG1-Fc, directed evolution approaches that screen for stability and use of the scaffold IgG1-Fc in the design of antigen binding Fc proteins. PMID:24451126

  1. Impacts, Effectiveness and Regional Inequalities of the GeoMIP G1 to G4 Solar Radiation Management Scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Xiaoyong; Moore, John; Cui, Xuefeng; Rinke, Annette; Ji, Duoying; Kravitz, Benjamin S.; Yoon, Jin-Ho

    2015-06-01

    We evaluate the regional effectiveness of solar radiation management (SRM) to compensate for simultaneous changes in temperature and precipitation induced by increased greenhouse gas concentrations. We analyze results from multiple earth system models under four Geoengineering Model Intercomparison Project(GeoMIP) experiments with a modified form of the Residual Climate Response approach. Under the solar dimming geoengineering experiments G1(4xCO2) and G2(increasing CO2 by 1% per year), global average temperature is successfully restored to pre-industrial level over 50 years simulations. However, these two SRM experiments also produce a robust global precipitation decrease. The stratospheric aerosol GeoMIP geoengineering experiment, G4 has significantly greater regional inequality and lower effectiveness for compensating temperature change than G1 and G2. G4 also has significantly larger regional inequality for compensating precipitation change than G1and G2. However, there is no significant difference between precipitation change compensation effectiveness of G4 and G2, though there is much larger across model variability in G4 results. G3 has significant greater regional inequality for compensating temperature change than G1 and G2, and has significant lower effectiveness than G1. The effectiveness of four SRMs to compensate for temperature change is much higher than for precipitation. The large cross-model variation in adjustment percentage of compensated SAT and precipitation change by SRM to achieve optimal compensation effectiveness shed a light on the uncertainty accumulation effect in optimizing compensation effectiveness of SRM.

  2. Predominance of rotavirus G1[P8] genotype among under-five children with gastroenteritis in Mwanza, Tanzania.

    Science.gov (United States)

    Hokororo, Adolfine; Kidenya, Benson R; Seni, Jeremiah; Mapaseka, Seheri; Mphahlele, Jeffrey; Mshana, Stephen E

    2014-10-01

    We analyzed stool samples from underfives with gastroenteritis for rotavirus infection between January 2010 and June 2011. A total of 393 stool specimens were examined for rotavirus infection using enzyme-linked immunosorbent assay (ELISA). Hundred selected positive specimens were genotyped using multiplex polymerase chain reaction. Out of 393 underfives, 194 (49.4%) had rotavirus infection, with 96.9% of infected underfives being rotavirus had prolonged hospital stay than those without rotavirus infection (P = 0.0001). G1 was the most predominant G type (59%) followed by G8 (13%) while P[8] was the most predominant P type (25%). In single-type infection, common G-P combinations were G1P[8] (24%) and G1P[6] (17%). Common mixed infections were G1/G8 (16%) and P4/P8 (13%). G1 genotype is common among underfives with gastroenteritis in Mwanza. Diversity of genotypes causing gastroenteritis in Mwanza necessitates a continuous surveillance after the introduction of RotaRix® vaccine. © The Author [2014]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  3. From Coins to Big Bucks: The Evolution of General-Purpose Reloadable Prepaid Cards

    OpenAIRE

    Bennett, Jeannette N.

    2015-01-01

    Prepaid cards were invented to solve a problem: replacing coin usage in pay telephones. Since then, prepaid cards have evolved into a huge competitive market for general-purpose reloadable (GPR) prepaid cards. Read more about GPR prepaid cards in the inaugural edition of Page One Economics Focus on Finance.

  4. Jeu de cartes or Jeu Descartes: Business Cards in a French Course for the Professions.

    Science.gov (United States)

    Gegerias, Mary

    This paper discusses the use of French business cards in a college-level French language and culture course for professionals. Among other assignments, students were each given a different card and asked to speak about the design of their card, the business represented, idiomatic expressions and historical allusions on the card, and the use of…

  5. 31 CFR 543.409 - Credit extended and cards issued by U.S. financial institutions.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Credit extended and cards issued by U...'IVOIRE SANCTIONS REGULATIONS Interpretations § 543.409 Credit extended and cards issued by U.S. financial..., charge cards, debit cards, or other credit facilities issued by a U.S. financial institution to a person...

  6. 31 CFR 547.409 - Credit extended and cards issued by U.S. financial institutions.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Credit extended and cards issued by U... DEMOCRATIC REPUBLIC OF THE CONGO SANCTIONS REGULATIONS Interpretations § 547.409 Credit extended and cards..., including, but not limited to, charge cards, debit cards, or other credit facilities issued by a U.S...

  7. 31 CFR 594.410 - Credit extended and cards issued by U.S. financial institutions.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Credit extended and cards issued by U... TERRORISM SANCTIONS REGULATIONS Interpretations § 594.410 Credit extended and cards issued by U.S. financial... agreements, including, but not limited to, charge cards, debit cards, or other credit facilities issued by a...

  8. 31 CFR 546.409 - Credit extended and cards issued by U.S. financial institutions.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Credit extended and cards issued by U... SANCTIONS REGULATIONS Interpretations § 546.409 Credit extended and cards issued by U.S. financial..., charge cards, debit cards, or other credit facilities issued by a U.S. financial institution to a person...

  9. 31 CFR 548.409 - Credit extended and cards issued by U.S. financial institutions.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Credit extended and cards issued by U... SANCTIONS REGULATIONS Interpretations § 548.409 Credit extended and cards issued by U.S. financial..., charge cards, debit cards, or other credit facilities issued by a U.S. financial institution to a person...

  10. 31 CFR 588.409 - Credit extended and cards issued by U.S. financial institutions.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Credit extended and cards issued by U... BALKANS STABILIZATION REGULATIONS Interpretations § 588.409 Credit extended and cards issued by U.S... not limited to, charge cards, debit cards, or other credit facilities issued by a U.S. financial...

  11. 31 CFR 542.409 - Credit extended and cards issued by U.S. financial institutions.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Credit extended and cards issued by U... SANCTIONS REGULATIONS Interpretations § 542.409 Credit extended and cards issued by U.S. financial..., charge cards, debit cards, or other credit facilities issued by a U.S. financial institution to a person...

  12. 12 CFR 226.5a - Credit and charge card applications and solicitations.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Credit and charge card applications and... required under this section on or with a solicitation or an application to open a credit or charge card... offer by the card issuer to open a credit or charge card account that does not require the consumer to...

  13. 31 CFR 598.409 - Credit extended and cards issued by U.S. financial institutions.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Credit extended and cards issued by U... NARCOTICS KINGPIN SANCTIONS REGULATIONS Interpretations § 598.409 Credit extended and cards issued by U.S... existing credit agreements, including, but not limited to, charge cards, debit cards, or other credit...

  14. 31 CFR 536.409 - Credit extended and cards issued by U.S. financial institutions.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Credit extended and cards issued by U... NARCOTICS TRAFFICKING SANCTIONS REGULATIONS Interpretations § 536.409 Credit extended and cards issued by U... any existing credit agreements, including, but not limited to, charge cards, debit cards, or other...

  15. 41 CFR 109-38.801 - Obtaining SF 149, U.S. Government National Credit Card.

    Science.gov (United States)

    2010-07-01

    .... Government National Credit Card. 109-38.801 Section 109-38.801 Public Contracts and Property Management..., U.S. Government National Credit Card § 109-38.801 Obtaining SF 149, U.S. Government National Credit Card. DOE offices electing to use national credit cards shall request the assignment of billing address...

  16. 31 CFR 593.409 - Credit extended and cards issued by U.S. financial institutions.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Credit extended and cards issued by U... LIBERIAN REGIME OF CHARLES TAYLOR SANCTIONS REGULATIONS Interpretations § 593.409 Credit extended and cards..., including, but not limited to, charge cards, debit cards, or other credit facilities issued by a U.S...

  17. 31 CFR 541.408 - Credit extended and cards issued by U.S. financial institutions.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Credit extended and cards issued by U... ZIMBABWE SANCTIONS REGULATIONS Interpretations § 541.408 Credit extended and cards issued by U.S. financial..., charge cards, debit cards, or other credit facilities issued by a U.S. financial institution to a person...

  18. Improving computer security by health smart card.

    Science.gov (United States)

    Nisand, Gabriel; Allaert, François-André; Brézillon, Régine; Isphording, Wilhem; Roeslin, Norbert

    2003-01-01

    The University hospitals of Strasbourg have worked for several years on the computer security of the medical data and have of this fact be the first to use the Health Care Professional Smart Card (CPS). This new tool must provide security to the information processing systems and especially to the medical data exchanges between the partners who collaborate to the care of the Beyond the purely data-processing aspects of the functions of safety offered by the CPS, safety depends above all on the practices on the users, their knowledge concerning the legislation, the risks and the stakes, of their adhesion to the procedures and protections installations. The aim of this study is to evaluate this level of knowledge, the practices and the feelings of the users concerning the computer security of the medical data, to check the relevance of the step taken, and if required, to try to improve it. The survey by questionnaires involved 648 users. The practices of users in terms of data security are clearly improved by the implementation of the security server and the use of the CPS system, but security breaches due to bad practices are not however completely eliminated. That confirms that is illusory to believe that data security is first and foremost a technical issue. Technical measures are of course indispensable, but the greatest efforts are required after their implementation and consist in making the key players [2], i.e. users, aware and responsible. However, it must be stressed that the user-friendliness of the security interface has a major effect on the results observed. For instance, it is highly probable that the bad practices continued or introduced upon the implementation of the security server and CPS scheme are due to the complicated nature or functional defects of the proposed solution, which must therefore be improved. Besides, this is only the pilot phase and card holders can be expected to become more responsible as time goes by, along with the gradual

  19. Precision measurements of g1 of the proton and the deuteron with 6 GeV electrons

    Energy Technology Data Exchange (ETDEWEB)

    Prok, Yelena; Bosted, Peter; Kvaltine, Nicholas; Adhikari, Krishna; Adikaram-Mudiyanselage, Dasuni; Aghasyan, Mher; Amaryan, Moskov; Anderson, Mark; Anefalos Pereira, Sergio; Avagyan, Harutyun; Baghdasaryan, Hovhannes; Ball, Jacques; Baltzell, Nathan; Battaglieri, Marco; Biselli, Angela; Bono, Jason; Briscoe, William; Brock, Joseph; Brooks, William; Bueltmann, Stephen; Burkert, Volker; Carlin, Christopher; Carman, Daniel; Celentano, Andrea; Chandavar, Shloka; Colaneri, Luca; Cole, Philip; Contalbrigo, Marco; Cortes, Olga; Crabb, Donald; Crede, Volker; D' Angelo, Annalisa; Dashyan, Natalya; De Vita, Raffaella; De Sanctis, Enzo; Deur, Alexandre; Djalali, Chaden; Dodge, Gail; Doughty, David; Dupre, Raphael; El Alaoui, Ahmed; El Fassi, Lamiaa; Elouadrhiri, Latifa; Fedotov, Gleb; Fegan, Stuart; Fersch, Robert; Fleming, Jamie; Forest, Tony; Garcon, Michel; Gevorgyan, Nerses; Ghandilyan, Yeranuhi; Gilfoyle, Gerard; Girod-Gard, Francois-Xavier; Giovanetti, Kevin; Goetz, John; Gohn, Wesley; Gothe, Ralf; Griffioen, Keith; Guegan, Baptiste; Guler, Nevzat; Hafidi, Kawtar; Hanretty, Charles; Harrison, Nathan; Hattawy, Mohammad; Hicks, Kenneth; Ho, Dao; Holtrop, Maurik; Ilieva, Yordanka; Ireland, David; Ishkhanov, Boris; Isupov, Evgeny; Jawalkar, Sucheta; Jiang, Xiaodong; Jo, Hyon-Suk; Joo, Kyungseon; Kalantarians, Narbe; Keith, Christopher; Keller, Daniel; Khandaker, Mahbubul; Kim, Andrey; Kim, Wooyoung; Klein, Andreas; Klein, Franz; Koirala, Suman; Kubarovsky, Valery; Kuhn, Sebastian; Kuleshov, Sergey; Lenisa, Paolo; Livingston, Kenneth; Lu, Haiyun; MacGregor, Ian; Markov, Nikolai; Mayer, Michael; McKinnon, Bryan; Meekins, David; Mineeva, Taisiya; Mirazita, Marco; Mokeev, Viktor; Montgomery, Rachel; MOUTARDE, Herve; Movsisyan, Aram; Munevar Espitia, Edwin; Munoz Camacho, Carlos; Nadel-Turonski, Pawel; Niccolai, Silvia; Niculescu, Gabriel; Niculescu, Maria; Osipenko, Mikhail; Ostrovidov, Alexander; Pappalardo, Luciano; Paremuzyan, Rafayel; Park, K; Peng, Peng; Phillips, J J; Pierce, Joshua; Pisano, Silvia; Pogorelko, Oleg; Pozdniakov, Serguei; Price, John; Procureur, Sebastien; Protopopescu, Dan; Puckett, Andrew; Raue, Brian; Rimal, Dipak; Ripani, Marco; Rizzo, Alessandro; Rosner, Guenther; Rossi, Patrizia; Roy, Priyashree; Sabatie, Franck; Saini, Mukesh; Salgado, Carlos; Schott, Diane; Schumacher, Reinhard; Seder, Erin; Sharabian, Youri; Simonyan, Ani; Smith, Claude; Smith, Gregory; Sober, Daniel; Sokhan, Daria; Stepanyan, Stepan; Stepanyan, Samuel; Strakovski, Igor; Strauch, Steffen; Sytnik, Valeriy; Taiuti, Mauro; Tang, Wei; Tkachenko, Svyatoslav; Ungaro, Maurizio; Vernarsky, Brian; Vlasov, Alexander; Voskanyan, Hakob; Voutier, Eric; Walford, Natalie; Watts, Daniel; Weinstein, Lawrence; Zachariou, Nicholas; Zana, Lorenzo; Zhang, Jixie; Zhao, Bo; Zhao, Zhiwen; Zonta, Irene

    2014-08-01

    The inclusive polarized structure functions of the proton and deuteron, g1p and g1d, were measured with high statistical precision using polarized 6 GeV electrons incident on a polarized ammonia target in Hall B at Jefferson Laboratory. Electrons scattered at lab angles between 18 and 45 degrees were detected using the CEBAF Large Acceptance Spectrometer (CLAS). For the usual DIS kinematics, Q^2>1 GeV^2 and the final-state invariant mass W>2 GeV, the ratio of polarized to unpolarized structure functions g1/F1 is found to be nearly independent of Q^2 at fixed x. Significant resonant structure is apparent at values of W up to 2.3 GeV. In the framework of perturbative QCD, the high-W results can be used to better constrain the polarization of quarks and gluons in the nucleon, as well as high-twist contributions.

  20. G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter

    DEFF Research Database (Denmark)

    Dou, Q P; Zhao, S; Levin, A H

    1994-01-01

    By performing DNase I footprint analysis, we had identified three distinct protein binding sequences (MT1, MT2, and MT3) located on the mouse thymidine kinase (TK) upstream promoter (Dou, Q.-P., Fridovich-Keil, J. L., and Pardee, A.B. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 1157-1161). Here we....... (iii) Formation of both these DNA-protein complexes were cell cycle-dependent: a G0/G1 phase-specific complex (E2F.G0/G1) was replaced by an S phase-specific complex(es) (E2F.S), whereas "free" E2F increased after the G1/S transition. (iv) Pulse inhibition of protein synthesis with cycloheximide...

  1. Mean time for the development of large workloads and large queue lengths in the GI/G/1 queue

    Directory of Open Access Journals (Sweden)

    Charles Knessl

    1996-01-01

    Full Text Available We consider the GI/G/1 queue described by either the workload U(t (unfinished work or the number of customers N(t in the system. We compute the mean time until U(t reaches excess of the level K, and also the mean time until N(t reaches N0. For the M/G/1 and GI/M/1 models, we obtain exact contour integral representations for these mean first passage times. We then compute the mean times asymptotically, as K and N0→∞, by evaluating these contour integrals. For the general GI/G/1 model, we obtain asymptotic results by a singular perturbation analysis of the appropriate backward Kolmogorov equation(s. Numerical comparisons show that the asymptotic formulas are very accurate even for moderate values of K and N0.

  2. Improvement of vascular function by acute and chronic treatment with the GPR30 agonist G1 in experimental diabetes mellitus.

    Directory of Open Access Journals (Sweden)

    Zi-lin Li

    Full Text Available The G-protein coupled estrogen receptor 30 (GPR30 is a seven-transmembrane domain receptor that mediates rapid estrogen responses in a wide variety of cell types. This receptor is highly expressed in the cardiovascular system, and exerts vasodilatory effects. The objective of the present study was to investigate the effects of GPR30 on vascular responsiveness in diabetic ovariectomized (OVX rats and elucidate the possible mechanism involved. The roles of GPR30 were evaluated in the thoracic aorta and cultured endothelial cells. The GPR30 agonist G1 induced a dose-dependent vasodilation in the thoracic aorta of the diabetic OVX rats, which was partially attenuated by the nitric oxide synthase (NOS inhibitor, nitro-L-arginine methylester (L-NAME and the GPR30-selective antagonist G15. Dose-dependent vasoconstrictive responses to phenylephrine were attenuated significantly in the rings of the thoracic aorta following the acute G1 administration in the diabetic OVX rats. This effect of G1 was abolished partially by L-NAME and G15. The acute administration of G1 increased significantly the eNOS activity and the concentration of NO in the endothelial cells exposed to high glucose. G1 treatment induced an enhanced endothelium-dependent relaxation to acetylcholine (Ach in the diabetic OVX rats. Further examination revealed that G1 induced vasodilation in the diabetic OVX rats by increasing the phosphorylation of eNOS. These findings provide preliminary evidence that GPR30 activation leads to eNOS activation, as well as vasodilation, to a certain degree and has beneficial effects on vascular function in diabetic OVX rats.

  3. A novel single virus infection system reveals that influenza virus preferentially infects cells in g1 phase.

    Directory of Open Access Journals (Sweden)

    Ryuta Ueda

    Full Text Available BACKGROUND: Influenza virus attaches to sialic acid residues on the surface of host cells via the hemagglutinin (HA, a glycoprotein expressed on the viral envelope, and enters into the cytoplasm by receptor-mediated endocytosis. The viral genome is released and transported in to the nucleus, where transcription and replication take place. However, cellular factors affecting the influenza virus infection such as the cell cycle remain uncharacterized. METHODS/RESULTS: To resolve the influence of cell cycle on influenza virus infection, we performed a single-virus infection analysis using optical tweezers. Using this newly developed single-virus infection system, the fluorescence-labeled influenza virus was trapped on a microchip using a laser (1064 nm at 0.6 W, transported, and released onto individual H292 human lung epithelial cells. Interestingly, the influenza virus attached selectively to cells in the G1-phase. To clarify the molecular differences between cells in G1- and S/G2/M-phase, we performed several physical and chemical assays. Results indicated that: 1 the membranes of cells in G1-phase contained greater amounts of sialic acids (glycoproteins than the membranes of cells in S/G2/M-phase; 2 the membrane stiffness of cells in S/G2/M-phase is more rigid than those in G1-phase by measurement using optical tweezers; and 3 S/G2/M-phase cells contained higher content of Gb3, Gb4 and GlcCer than G1-phase cells by an assay for lipid composition. CONCLUSIONS: A novel single-virus infection system was developed to characterize the difference in influenza virus susceptibility between G1- and S/G2/M-phase cells. Differences in virus binding specificity were associated with alterations in the lipid composition, sialic acid content, and membrane stiffness. This single-virus infection system will be useful for studying the infection mechanisms of other viruses.

  4. Association of pKi-67 with satellite DNA of the human genome in early G1 cells.

    Science.gov (United States)

    Bridger, J M; Kill, I R; Lichter, P

    1998-01-01

    pKi-67 is a nucleolar antigen that provides a specific marker for proliferating cells. It has been shown previously that pKi-67's distribution varies in a cell cycle-dependent manner: it coats all chromosomes during mitosis, accumulates in nuclear foci during G1 phase (type I distribution) and localizes within nucleoli in late G1 S and G2 phase (type II distribution). Although no function has as yet been ascribed to pKi-67, it has been found associated with centromeres in G1. In the present study the distribution pattern of pKi-67 during G1 in human dermal fibroblasts (HDFs) was analysed in more detail. Synchronization experiments show that in very early G1 cells pKi-67 coincides with virtually all satellite regions analysed, i.e. with centromeric (alpha-satellite), telomeric (minisatellite) and heterochromatic blocks (satellite III) on chromosomes 1 and Y (type Ia distribution). In contrast, later in the G1 phase, a smaller fraction of satellite DNA regions are found collocalized with pKi-67 foci (type Ib distribution). When all pKi-67 becomes localized within nucleoli, even fewer satellite regions remain associated with the pKi-67 staining. However, all centromeric and short arm regions of the acrocentric chromosomes, which are in very close proximity to or even contain the rRNA genes, are collocalized with anti-pKi-67 staining throughout the remaining interphase of the cell cycle. Thus, our data demonstrate that during post-mitotic reformation and nucleogenesis there is a progressive decline in the fraction of specific satellite regions of DNA that remain associated with pKi-67. This may be relevant to nucleolar reformation following mitosis.

  5. Timing of the G1/S transition in tobacco pollen vegetative cells as a primary step towards androgenesis in vitro.

    Science.gov (United States)

    Kyo, Masaharu; Nagano, Ai; Yamaji, Naoki; Hashimoto, Yuhki

    2014-09-01

    Mid-bicellular pollen vegetative cells in tobacco escape from G1 arrest and proceed to the G1/S transition towards androgenesis within 1 day under glutamine starvation conditions in vitro. In the Nicotiana tabacum pollen culture system, immature pollen grains at the mid-bicellular stage can mature in the presence of glutamine; however, if glutamine is absent, they deviate from their native cell fate in a few days. The glutamine-starved pollen grains cannot undergo maturation, even when supplied with glutamine later. Instead, they undergo cell division towards androgenesis slowly within 10 days in a medium containing appropriate nutrients. During the culture period, they ought to escape from G1 arrest to proceed into S phase as the primary step towards androgenesis. However, this event has not been experimentally confirmed. Here, we demonstrated that the pollen vegetative cells proceeded to the G1/S transition within approximately 15-36 h after the start of culture. These results were obtained by analyzing transgenic pollen possessing a fusion gene encoding nuclear-localizing GFP under the control of an E2F motif-containing promoter isolated from a gene encoding one of DNA replication licensing factors. Observations using a 5-ethynyl-2'-deoxyuridine DNA labeling and detection technique uncovered that the G1/S transition was soon followed by S phase. These hallmarks of vegetative cells undergoing dedifferentiation give us new insights into upstream events causing the G1/S transition and also provide a novel strategy to increase the frequency of the androgenic response in tobacco and other species, including recalcitrants.

  6. Are mobile payments the smart cards of the aughts?

    OpenAIRE

    Katy Jacob

    2007-01-01

    This article compares the much anticipated but ultimately stalled smart card revolution of the 1990s with the current expansion of mobile payment platforms, and asks how mobile payments fit into the larger payment system.

  7. Ridership impacts of South Florida's EASY smart card : [summary].

    Science.gov (United States)

    2013-07-01

    Transit agencies across the U.S. increasingly are replacing electronic fare reading systems with Advanced Fare Collection (AFC) or smart card systems. In 2009, Miami-Dade Transit (MDT) was the first Florida transit agency to deploy AFC, branded...

  8. Kolonel Cristian Carde - tõeline klassik / Ingrid Randlaht

    Index Scriptorium Estoniae

    Randlaht, Ingrid

    2012-01-01

    Cristian Cardest, kes on Prantsuse Saumuri sõjaväelise kõrgema ratsakooli Cader Noir pearatsastaja olnud kaheksa aastat ning juhtinud ka Prantsusmaa aegade parimat koolisõidukoondist. Juunikuus Soomes Nummis toimunud Cristian Carde ratsakliinikust

  9. Concretization and animation of Finite Automata with c-cards

    DEFF Research Database (Denmark)

    Valente, Andrea

    2004-01-01

    to classes of 10 to 12 years old, and in general to students with a limited mathematical background. Our approach builds on {\\em computational cards} (or c-cards), a project aiming at scaling-down the learning complexity of computer science core contents, by presenting symbol manipulation via a t......-cards is given and its educational implication discussed: the mapping provides a mean to concretize and animate automata. The algorithm works with both deterministic and non-deterministic finite automata....... a tangible, physical metaphor. C-cards are still at a very early stage of development as an educational tool, yet we believe they represent a nice, intuitive mind-tool, that can be consistently applied to a variety of (theoretical) computer science concepts. Here an algorithm for mapping finite automata on c...

  10. Blau syndrome associated with a CARD15/NOD2 mutation.

    Science.gov (United States)

    Snyers, Bernadette; Dahan, Karin

    2006-12-01

    To report a new family with Blau syndrome caused by CARD15/NOD2 mutation. Observational case series. Detailed clinical evaluation in three affected relatives with Blau syndrome. Haplotype and mutation analysis of the CARD15/NOD2 gene were performed. Ocular manifestations identified in the proband include bilateral band keratopathy, cataract, iritis, vitritis and severe granulomatous choroidopathy. The mother and one brother of the proband exhibit the same characteristic organ involvements of this disease. Haplotype analysis from the pericentromeric region on chromosome 16 identified a common haplotype in all affected relatives that is absent in unaffected relatives. Sequencing analysis revealed a heterozygous pathogenic mutation in the CARD15/NOD2 gene, the previously reported p.R334W substitution. Blau syndrome is a rare autosomal-dominant disease that can lead to severe visual impairment. The search of a CARD15/NOD2 mutation could be helpful in the differential diagnosis of childhood uveitis.

  11. Satisfaction with Service for Internet Medicare Replacement Cards

    Data.gov (United States)

    Social Security Administration — This dataset contains results of Internet Report Card iRequest Survey conducted by mail between April and June 2014 using a brief scannable “report card” style...

  12. Russian Basic Course: Aural Comprehension Enrichment Word Cards.

    Science.gov (United States)

    Defense Language Inst., Washington, DC.

    Several hundred military terms in Russian are contained in this pamphlet. Terms pertaining to army, navy, and air force weaponry and procedures are presented on aural comprehension enrichment word cards with English translations on the reverse side. (RL)

  13. Application of Data Mining for Card Fraud Detection

    Directory of Open Access Journals (Sweden)

    I.V. Andrianov

    2012-03-01

    Full Text Available This paper focuses on implementing Data Mining methods for card fraud detection. The approach to classification and prediction tasks for detection of unauthorized transactions is considered.

  14. Credit Cards, Economization of Money, and Interest Rates.

    Science.gov (United States)

    Steindl, Frank G.

    2000-01-01

    Focuses on the effect of interest rates on the increased use of credit cards, a popular method of financing households. Uses three models to demonstrate that interest rates must rise, resulting in increased consumption expenditures. (CMK)

  15. War 2010: The Emergence of the Wild Card Scenario

    National Research Council Canada - National Science Library

    Rosello, Victor

    1997-01-01

    This research paper explores the possibility of using prophecy-based predictions to create worst case scenarios or 'wild cards,' when examined within the context of current trends and indicators of world threats...

  16. DATA BREACHES: WHAT THE UNDERGROUND WORLD OF "CARDING" REVEALS

    National Research Council Canada - National Science Library

    Kimberly Kiefer Peretti

    2009-01-01

    ...: large scale data breaches by skilled hackers. This article first provides a brief background on large scale data breaches and the criminal "carding" organizations that are responsible for exploiting the stolen data...

  17. Base substitution mutations in uridinediphosphate-dependent glycosyltransferase 76G1 gene of Stevia rebaudiana causes the low levels of rebaudioside A: mutations in UGT76G1, a key gene of steviol glycosides synthesis.

    Science.gov (United States)

    Yang, Yong-Heng; Huang, Su-Zhen; Han, Yu-Lin; Yuan, Hai-Yan; Gu, Chun-Sun; Zhao, Yan-Hai

    2014-07-01

    Steviol glycosides, extracted from the leaves of Stevia rebaudiana (Bert) Bertoni, are calorie-free sugar substitute of natural origin with intensely sweet (Boileau et al., 2012). Stevioside and rebaudioside A are the two main kinds of the diterpenic glycosides. We analyzed the concentration of stevioside and rebaudioside A in Stevia leaves of about 500 samples (hybrid progenies) and discovered a mutation plant "Z05" with very low levels of rebaudioside A. Because UGT76G1, a uridinediphosphate-dependent glycosyltransferases, is responsible for the conversion from stevioside to rebaudioside A (Richman et al., 2005), so mutation identification was done by sequencing the candidate gene, UGT76G1. In this study molecular analysis of two strains revealed a heterozygotic nonsense mutation of c.389T > G (p.L121X) in UGT76G1. Meanwhile, we found some amino acid substitutions significant change the protein structure. And the difference of enzyme activity between two strains proved the lack of functionality of UGT76G1 of the mutation "Z05". So the nonsense mutation and amino acid substitution mutation resulted in the low levels of rebaudioside A. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  18. Glut1 deficiency (G1D): epilepsy and metabolic dysfunction in a mouse model of the most common human phenotype.

    Science.gov (United States)

    Marin-Valencia, Isaac; Good, Levi B; Ma, Qian; Duarte, Joao; Bottiglieri, Teodoro; Sinton, Christopher M; Heilig, Charles W; Pascual, Juan M

    2012-10-01

    Brain glucose supplies most of the carbon required for acetyl-coenzyme A (acetyl-CoA) generation (an important step for myelin synthesis) and for neurotransmitter production via further metabolism of acetyl-CoA in the tricarboxylic acid (TCA) cycle. However, it is not known whether reduced brain glucose transporter type I (GLUT-1) activity, the hallmark of the GLUT-1 deficiency (G1D) syndrome, leads to acetyl-CoA, TCA or neurotransmitter depletion. This question is relevant because, in its most common form in man, G1D is associated with cerebral hypomyelination (manifested as microcephaly) and epilepsy, suggestive of acetyl-CoA depletion and neurotransmitter dysfunction, respectively. Yet, brain metabolism in G1D remains underexplored both theoretically and experimentally, partly because computational models of limited brain glucose transport are subordinate to metabolic assumptions and partly because current hemizygous G1D mouse models manifest a mild phenotype not easily amenable to investigation. In contrast, adult antisense G1D mice replicate the human phenotype of spontaneous epilepsy associated with robust thalamocortical electrical oscillations. Additionally, and in consonance with human metabolic imaging observations, thalamus and cerebral cortex display the lowest GLUT-1 expression and glucose uptake in the mutant mouse. This depletion of brain glucose is associated with diminished plasma fatty acids and elevated ketone body levels, and with decreased brain acetyl-CoA and fatty acid contents, consistent with brain ketone body consumption and with stimulation of brain beta-oxidation and/or diminished cerebral lipid synthesis. In contrast with other epilepsies, astrocyte glutamine synthetase expression, cerebral TCA cycle intermediates, amino acid and amine neurotransmitter contents are also intact in G1D. The data suggest that the TCA cycle is preserved in G1D because reduced glycolysis and acetyl-CoA formation can be balanced by enhanced ketone body

  19. Evaluation of Palm PCRTM G1-12 System: a portable battery-operated PCR thermal cycler

    Directory of Open Access Journals (Sweden)

    Siti Aminah Ahmed

    2016-08-01

    Full Text Available Polymerase chain reaction (PCR is the basis of recombinant and other molecular biological techniques. Availability of cheap and robust PCR platforms enables the tests to be performed easily, even in resource constrained settings. Herein we compared the efficacy of a portable thermal cycler ( Palm PCRTM G1-12 System for rapid DNA amplification against the standard Peltier-based thermal cycler using plasmid DNA and genomic DNA in single and multiplex PCR experiments. Our study revealed that the Palm PCRTM G1-12 System could be a portable DNA amplification system to conduct various molecular techniques, especially in places where resources are limited.

  20. G1 cyclin degradation: the PEST motif of yeast Cln2 is necessary, but not sufficient, for rapid protein turnover.

    OpenAIRE

    Salama, S R; Hendricks, K B; Thorner, J

    1994-01-01

    The 545-residue Cln2 protein, like the other G1 cyclins of Saccharomyces cerevisiae, is a very unstable protein. This instability is thought to play a critical role in regulating cell cycle progression. The carboxyl-terminal domains of Cln2 and the other G1 cyclins contain sequences rich in Pro, Glu (and Asp), Ser, and Thr (so-called PEST motifs) that have been postulated to make up the signals that are responsible for the rapid degradation of these and other unstable proteins. To test this h...

  1. Piperine Causes G1 Phase Cell Cycle Arrest and Apoptosis in Melanoma Cells through Checkpoint Kinase-1 Activation

    OpenAIRE

    Fofaria, Neel M.; Sung-Hoon Kim; Sanjay K. Srivastava

    2014-01-01

    In this study, we determined the cytotoxic effects of piperine, a major constituent of black and long pepper in melanoma cells. Piperine treatment inhibited the growth of SK MEL 28 and B16 F0 cells in a dose and time-dependent manner. The growth inhibitory effects of piperine were mediated by cell cycle arrest of both the cell lines in G1 phase. The G1 arrest by piperine correlated with the down-regulation of cyclin D1 and induction of p21. Furthermore, this growth arrest by piperine treatmen...

  2. Glut1 deficiency (G1D): Epilepsy and metabolic dysfunction in a mouse model of the most common human phenotype

    Science.gov (United States)

    Marin-Valencia, Isaac; Good, Levi B.; Ma, Qian; Duarte, Joao; Bottiglieri, Teodoro; Sinton, Christopher M.; Heilig, Charles W.; Pascual, Juan M.

    2012-01-01

    Brain glucose supplies most of the carbon required for acetyl-coenzyme A (acetyl-CoA) generation (an important step for myelin synthesis) and for neurotransmitter production via further metabolism of acetyl-CoA in the tricarboxylic acid (TCA) cycle. However, it is not known whether reduced brain glucose transporter type I (GLUT-1) activity, the hallmark of the GLUT-1 deficiency (G1D) syndrome, leads to acetyl-CoA, TCA or neurotransmitter depletion. This question is relevant because, in its most common form in man, G1D is associated with cerebral hypomyelination (manifested as microcephaly) and epilepsy, suggestive of acetyl-CoA depletion and neurotransmitter dysfunction, respectively. Yet, brain metabolism in G1D remains underexplored both theoretically and experimentally, partly because computational models of limited brain glucose transport are subordinate to metabolic assumptions and partly because current hemizygous G1D mouse models manifest a mild phenotype not easily amenable to investigation. In contrast, adult antisense G1D mice replicate the human phenotype of spontaneous epilepsy associated with robust thalamocortical electrical oscillations. Additionally, and in consonance with human metabolic imaging observations, thalamus and cerebral cortex display the lowest GLUT-1 expression and glucose uptake in the mutant mouse. This depletion of brain glucose is associated with diminished plasma fatty acids and elevated ketone body levels, and with decreased brain acetyl-CoA and fatty acid contents, consistent with brain ketone body consumption and with stimulation of brain beta-oxidation and/or diminished cerebral lipid synthesis. In contrast with other epilepsies, astrocyte glutamine synthetase expression, cerebral TCA cycle intermediates, amino acid and amine neurotransmitter contents are also intact in G1D. The data suggest that the TCA cycle is preserved in G1D because reduced glycolysis and acetyl-CoA formation can be balanced by enhanced ketone body

  3. Exploring Supermarket Loyalty Card Analysis to Identify Who Buys Fairtrade

    OpenAIRE

    Fred A. Yamoah; Fearne, Andrew; Duffy, Rachel; Petrovici, Dan Alex

    2013-01-01

    The aim of this paper is to show how supermarket loyalty card data from a panel of over 1.7 million \\ud shoppers can be analysed to provide behavioural segmentation insights to profile the fairtrade shopper \\ud in order to enhance making targeted marketing decisions. The paper demonstrates the huge marketing \\ud potential that loyalty card based shopper segmentation can bring to objectively describe who buys \\ud fairtrade products, compared to profiling shoppers with claimed/reported behaviou...

  4. Forum: House of Cards: Analyzing "Making Skills Everyone's Business "

    Science.gov (United States)

    St. Clair, Ralf

    2015-01-01

    When policy is made in a particular area, not only does one have to decide what to do but why he/she is doing it. Any plan for action is like a house of cards. At the bottom, there are assumptions. They hold up the next layer, which is the definition of the problem. At the top is the response, what is to be done. If any of the lower cards is not…

  5. Comprehensive aerological reference data set (CARDS)

    Energy Technology Data Exchange (ETDEWEB)

    Eskridge, R.E.; Polansky, A.C.; Alduchov, O.A. [National Oceanic and Atmospheric Administration, Asheville, NC (United States). National Climatic Data Center] [and others

    1997-11-01

    The possibility of anthropogenic climate change has reached the attention of Government officials and researchers. However, one cannot study climate change without climate data. The CARDS project will produce high-quality upper-air data for the research community and for policy-makers. The authors intend to produce a dataset which is: easy to use, as complete as possible, as free of random errors as possible. They will also attempt to identify biases and remove them whenever possible. In this report, they relate progress toward their goal. They created a robust new format for archiving upper-air data, and designed a relational database structure to hold them. The authors have converted 13 datasets to the new format and have archived over 10,000,000 individual soundings from 10 separate data sources. They produce and archive a metadata summary of each sounding they load. They have researched station histories, and have built a preliminary upper-air station history database. They have converted station-sorted data from their primary database into synoptic-sorted data in a parallel database. They have tested and will soon implement an advanced quality-control procedure, capable of detecting and often repairing errors in geopotential height, temperature, humidity, and wind. This unique quality-control method uses simultaneous vertical, horizontal, and temporal checks of several meteorological variables. It can detect errors other methods cannot.

  6. Automatic Identification Technology (AIT): The Development of Functional Capability and Card Application Matrices

    Science.gov (United States)

    1994-09-01

    using integrated circuit cards as financial transaction cards. [GEMPLUS] Smart card use is expected to be a key element in the truly cashless society ...83 2. Educational Service/Training/Job Placement .......................... 83 3. Pay Telephone ( Cashless Telephone Card...program for other states to use when implementing education and employment-related services. [WON9 1. pp. 9-11] 3. Pay Telephone ( Cashless Telephone Card

  7. Credit Card Fraud: The study of its impact and detection techniques

    OpenAIRE

    Khyati Chaudhary; Bhawna Mallick

    2012-01-01

    With the rise and swift growth of E-Commerce, credit card usesfor online purchases has increased dramatically and it causedsudden outbreak in the credit card fraud. Fraud is one of themajor ethical issues in the credit card industry. With both onlineas well as regular purchase, credit card becomes the most popularmode of payment with cases of fraud associated with it are alsoincreasing. A clear framework on all these approaches willcertainly lead to an efficient credit card fraud detection sy...

  8. A new service to ensure that PXI cards perform correctly

    CERN Document Server

    CERN Bulletin

    2013-01-01

    The PXI (PCI eXtensions for Instrumentation) card is an electronic module used in association with a PC to improve the performance of measurement and automation systems. At CERN, many systems use PXI cards. With the long shutdown providing ideal timing, a new interdepartmental initiative has created a PXI card calibration service. Don’t miss out!   Christine Leroy-Jonckx and Benjamin Ninet (next to the new calibration machine), display their National Instruments diplomas. PXI cards are used in both laboratories and accelerators, for test beds, data acquisition systems, installation testing, etc. “A survey of CERN PXI equipment users carried out in 2011 showed that there were more than 1500 cards and about 50 different models in use,” says Hubert Reymond, responsible for PXI support and promotion at CERN. “As for all electronic systems, the performance of these cards can vary over time. So for some of them, calibration is nece...

  9. Materialism and credit card use by college students.

    Science.gov (United States)

    Pinto, M B; Parente, D H; Palmer, T S

    2000-04-01

    Much has been written in the popular press on credit card use and spending patterns of American college students. The proliferation of credit cards and their ease of acquisition ensure that students today have more opportunities for making more credit purchases than any other generation of college students. Little is known about the relationship between students' attitudes towards materialism and their use of credit cards. A study was conducted at three college campuses in the northeastern part of the United States where a total of 1,022 students were surveyed. Students' attitudes toward use of credit and their credit card balances were evaluated relative to their scores on Richins and Dawson's Materialism Scale (1992). Our findings suggest no significant difference between those individuals scoring high versus low on the Materialism Scale in terms of the number of credit cards owned and the average balance owed. Individuals high on materialism, however, significantly differed in terms of their uses for credit cards and their general attitude toward their use.

  10. HyperCLIPS: A HyperCard interface to CLIPS

    Science.gov (United States)

    Pickering, Brad; Hill, Randall W., Jr.

    1990-01-01

    HyperCLIPS combines the intuitive, interactive user interface of the Apple Macintosh(TM) with the powerful symbolic computation of an expert system interpreter. HyperCard(TM) is an excellent environment for quickly developing the front end of an application with buttons, dialogs, and pictures, while the CLIPS interpreter provides a powerful inference engine for complex problem solving and analysis. By integrating HyperCard and CLIPS the advantages and uses of both packages are made available for a wide range of uses: rapid prototyping of knowledge-based expert systems, interactive simulations of physical systems, and intelligent control of hypertext processes, to name a few. Interfacing HyperCard and CLIPS is natural. HyperCard was designed to be extended through the use of external commands (XCMDs), and CLIPS was designed to be embedded through the use of the I/O router facilities and callable interface routines. With the exception of some technical difficulties which will be discussed later, HyperCLIPS implements this interface in a straight forward manner, using the facilities provided. An XCMD called 'ClipsX' was added to HyperCard to give access to the CLIPS routines: clear, load, reset, and run. And an I/O router was added to CLIPS to handle the communication of data between CLIPS and HyperCard.

  11. A credit card verifier structure using diffraction and spectroscopy concepts

    Science.gov (United States)

    Sumriddetchkajorn, Sarun; Intaravanne, Yuttana

    2008-04-01

    We propose and experimentally demonstrate an angle-multiplexing based optical structure for verifying a credit card. Our key idea comes from the fact that the fine detail of the embossed hologram stamped on the credit card is hard to duplicate and therefore its key color features can be used for distinguishing between the real and counterfeit ones. As the embossed hologram is a diffractive optical element, we choose to shine one at a time a number of broadband lightsources, each at different incident angle, on the embossed hologram of the credit card in such a way that different color spectra per incident angle beam is diffracted and separated in space. In this way, the number of pixels of each color plane is investigated. Then we apply a feed forward back propagation neural network configuration to separate the counterfeit credit card from the real one. Our experimental demonstration using two off-the-shelf broadband white light emitting diodes, one digital camera, a 3-layer neural network, and a notebook computer can identify all 69 counterfeit credit cards from eight real credit cards.

  12. The transient M/G/1/0 queue: some bounds and approximations for light traffic with application to reliability

    Directory of Open Access Journals (Sweden)

    J. Ben Atkinson

    1995-01-01

    Full Text Available We consider the transient analysis of the M/G/1/0 queue, for which Pn(t denotes the probability that there are no customers in the system at time t, given that there are n(n=0,1 customers in the system at time 0. The analysis, which is based upon coupling theory, leads to simple bounds on Pn(t for the M/G/1/0 and M/PH/1/0 queues and improved bounds for the special case M/Er/1/0. Numerical results are presented for various values of the mean arrival rate λ to demonstrate the increasing accuracy of approximations based upon the above bounds in light traffic, i.e., as λ→0. An important area of application for the M/G/1/0 queue is as a reliability model for a single repairable component. Since most practical reliability problems have λ values that are small relative to the mean service rate, the approximations are potentially useful in that context. A duality relation between the M/G/1/0 and GI/M/1/0 queues is also described.

  13. Isolation and characterization of a monoclonal anti CK-2 alpha subunit antibody of the IgG1 subclass

    DEFF Research Database (Denmark)

    Schmidt-Spaniol, I; Boldyreff, B; Issinger, O G

    1992-01-01

    A monoclonal antibody was produced against the recombinant human alpha subunit of CK-2. The antibody was of the IgG1 subclass and it was isolated from serum-free cell culture media and purified by affinity chromatography on Protein G Sepharose. The antibody can be used to detect specifically the ...

  14. G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase

    NARCIS (Netherlands)

    Schweiger, M.; Paar, M.; Eder, C.; Brandis, J.; Moser, E.; Gorkiewisz, G.; Grond, S.; Radner, F.P.W.; Cerk, I.; Cornaciu, I.; Oberer, M.; Kersten, A.H.; Zechner, R.; Zimmermann, M.B.; Lass, A.

    2012-01-01

    The hydrolysis of triglycerides in adipocytes, termed lipolysis, provides free fatty acids as energy fuel. Murine lipolysis largely depends on the activity of adipose triglyceride lipase (ATGL)5, which is regulated by two proteins annotated as comparative gene identification-58 (CGI-58) and G0/G1

  15. 26 CFR 1.904(g)-1T - Overall domestic loss and the overall domestic loss account (temporary).

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Overall domestic loss and the overall domestic... United States § 1.904(g)-1T Overall domestic loss and the overall domestic loss account (temporary). (a) Overview of regulations. This section provides rules for determining a taxpayer's overall domestic losses...

  16. Predicted 3D structures of olfactory receptors with details of odorant binding to OR1G1

    Science.gov (United States)

    Kim, Soo-Kyung; Goddard, William A.

    2014-12-01

    Olfactory receptors (ORs) are responsible for mediating the sense of smell; they allow humans to recognize an enormous number of odors but the connection between binding and perception is not known. We predict the ensemble of low energy structures for the human OR1G1 (hOR1G1) and also for six other diverse ORs, using the G protein-coupled receptor Ensemble of Structures in Membrane BiLayer Environment complete sampling method that samples 13 trillion different rotations and tilts using four different templates to predict the 24 structures likely to be important in binding and activation. Our predicted most stable structures of hOR1G1 have a salt-bridge between the conserved D3.49 and K6.30 in the D(E)RY region, that we expect to be associated with an inactive form. The hOR1G1 structure also has specific interaction in transmembrane domains (TMD) 3-6 (E3.39 and H6.40), which is likely an important conformational feature for all hORs because of the 94 to 98 % conservation among all hOR sequences. Of the five ligands studied (nonanal, 9-decen-1-ol, 1-nonanol, camphor, and n-butanal), we find that the 4 expected to bind lead to similar binding energies with nonanol the strongest.

  17. Genome-Wide Evolutionary Analyses of G1P[8] Strains Isolated Before and After Rotavirus Vaccine Introduction.

    Science.gov (United States)

    Zeller, Mark; Donato, Celeste; Trovão, Nídia Sequeira; Cowley, Daniel; Heylen, Elisabeth; Donker, Nicole C; McAllen, John K; Akopov, Asmik; Kirkness, Ewen F; Lemey, Philippe; Van Ranst, Marc; Matthijnssens, Jelle; Kirkwood, Carl D

    2015-08-08

    Rotaviruses are the most important etiological agent of acute gastroenteritis in young children worldwide. Among the first countries to introduce rotavirus vaccines into their national immunization programs were Belgium (November 2006) and Australia (July 2007). Surveillance programs in Belgium (since 1999) and Australia (since 1989) offer the opportunity to perform a detailed comparison of rotavirus strains circulating pre- and postvaccine introduction. G1P[8] rotaviruses are the most prominent genotype in humans, and a total of 157 G1P[8] rotaviruses isolated between 1999 and 2011 were selected from Belgium and Australia and their complete genomes were sequenced. Phylogenetic analysis showed evidence of frequent reassortment among Belgian and Australian G1P[8] rotaviruses. Although many different phylogenetic subclusters were present before and after vaccine introduction, some unique clusters were only identified after vaccine introduction, which could be due to natural fluctuation or the first signs of vaccine-driven evolution. The times to the most recent common ancestors for the Belgian and Australian G1P[8] rotaviruses ranged from 1846 to 1955 depending on the gene segment, with VP7 and NSP4 resulting in the most recent estimates. We found no evidence that rotavirus population size was affected after vaccine introduction and only six amino acid sites in VP2, VP3, VP7, and NSP1 were identified to be under positive selective pressure. Continued surveillance of G1P[8] strains is needed to determine long-term effects of vaccine introductions, particularly now rotavirus vaccines are implemented in the national immunization programs of an increasing number of countries worldwide. © The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  18. Piperine causes G1 phase cell cycle arrest and apoptosis in melanoma cells through checkpoint kinase-1 activation.

    Directory of Open Access Journals (Sweden)

    Neel M Fofaria

    Full Text Available In this study, we determined the cytotoxic effects of piperine, a major constituent of black and long pepper in melanoma cells. Piperine treatment inhibited the growth of SK MEL 28 and B16 F0 cells in a dose and time-dependent manner. The growth inhibitory effects of piperine were mediated by cell cycle arrest of both the cell lines in G1 phase. The G1 arrest by piperine correlated with the down-regulation of cyclin D1 and induction of p21. Furthermore, this growth arrest by piperine treatment was associated with DNA damage as indicated by phosphorylation of H2AX at Ser139, activation of ataxia telangiectasia and rad3-related protein (ATR and checkpoint kinase 1 (Chk1. Pretreatment with AZD 7762, a Chk1 inhibitor not only abrogated the activation of Chk1 but also piperine mediated G1 arrest. Similarly, transfection of cells with Chk1 siRNA completely protected the cells from G1 arrest induced by piperine. Piperine treatment caused down-regulation of E2F1 and phosphorylation of retinoblastoma protein (Rb. Apoptosis induced by piperine was associated with down-regulation of XIAP, Bid (full length and cleavage of Caspase-3 and PARP. Furthermore, our results showed that piperine treatment generated ROS in melanoma cells. Blocking ROS by tiron protected the cells from piperine mediated cell cycle arrest and apoptosis. These results suggest that piperine mediated ROS played a critical role in inducing DNA damage and activation of Chk1 leading to G1 cell cycle arrest and apoptosis.

  19. Dual regulation by pairs of cyclin-dependent protein kinases and histone deacetylases controls G1 transcription in budding yeast.

    Directory of Open Access Journals (Sweden)

    Dongqing Huang

    2009-09-01

    Full Text Available START-dependent transcription in Saccharomyces cerevisiae is regulated by two transcription factors SBF and MBF, whose activity is controlled by the binding of the repressor Whi5. Phosphorylation and removal of Whi5 by the cyclin-dependent kinase (CDK Cln3-Cdc28 alleviates the Whi5-dependent repression on SBF and MBF, initiating entry into a new cell cycle. This Whi5-SBF/MBF transcriptional circuit is analogous to the regulatory pathway in mammalian cells that features the E2F family of G1 transcription factors and the retinoblastoma tumor suppressor protein (Rb. Here we describe genetic and biochemical evidence for the involvement of another CDK, Pcl-Pho85, in regulating G1 transcription, via phosphorylation and inhibition of Whi5. We show that a strain deleted for both PHO85 and CLN3 has a slow growth phenotype, a G1 delay, and is severely compromised for SBF-dependent reporter gene expression, yet all of these defects are alleviated by deletion of WHI5. Our biochemical and genetic tests suggest Whi5 mediates repression in part through interaction with two histone deacetylases (HDACs, Hos3 and Rpd3. In a manner analogous to cyclin D/CDK4/6, which phosphorylates Rb in mammalian cells disrupting its association with HDACs, phosphorylation by the early G1 CDKs Cln3-Cdc28 and Pcl9-Pho85 inhibits association of Whi5 with the HDACs. Contributions from multiple CDKs may provide the precision and accuracy necessary to activate G1 transcription when both internal and external cues are optimal.

  20. Piperine causes G1 phase cell cycle arrest and apoptosis in melanoma cells through checkpoint kinase-1 activation.

    Science.gov (United States)

    Fofaria, Neel M; Kim, Sung-Hoon; Srivastava, Sanjay K

    2014-01-01

    In this study, we determined the cytotoxic effects of piperine, a major constituent of black and long pepper in melanoma cells. Piperine treatment inhibited the growth of SK MEL 28 and B16 F0 cells in a dose and time-dependent manner. The growth inhibitory effects of piperine were mediated by cell cycle arrest of both the cell lines in G1 phase. The G1 arrest by piperine correlated with the down-regulation of cyclin D1 and induction of p21. Furthermore, this growth arrest by piperine treatment was associated with DNA damage as indicated by phosphorylation of H2AX at Ser139, activation of ataxia telangiectasia and rad3-related protein (ATR) and checkpoint kinase 1 (Chk1). Pretreatment with AZD 7762, a Chk1 inhibitor not only abrogated the activation of Chk1 but also piperine mediated G1 arrest. Similarly, transfection of cells with Chk1 siRNA completely protected the cells from G1 arrest induced by piperine. Piperine treatment caused down-regulation of E2F1 and phosphorylation of retinoblastoma protein (Rb). Apoptosis induced by piperine was associated with down-regulation of XIAP, Bid (full length) and cleavage of Caspase-3 and PARP. Furthermore, our results showed that piperine treatment generated ROS in melanoma cells. Blocking ROS by tiron protected the cells from piperine mediated cell cycle arrest and apoptosis. These results suggest that piperine mediated ROS played a critical role in inducing DNA damage and activation of Chk1 leading to G1 cell cycle arrest and apoptosis.

  1. Genome-Wide Evolutionary Analyses of G1P[8] Strains Isolated Before and After Rotavirus Vaccine Introduction

    Science.gov (United States)

    Zeller, Mark; Donato, Celeste; Trovão, Nídia Sequeira; Cowley, Daniel; Heylen, Elisabeth; Donker, Nicole C.; McAllen, John K.; Akopov, Asmik; Kirkness, Ewen F.; Lemey, Philippe; Van Ranst, Marc; Matthijnssens, Jelle; Kirkwood, Carl D.

    2015-01-01

    Rotaviruses are the most important etiological agent of acute gastroenteritis in young children worldwide. Among the first countries to introduce rotavirus vaccines into their national immunization programs were Belgium (November 2006) and Australia (July 2007). Surveillance programs in Belgium (since 1999) and Australia (since 1989) offer the opportunity to perform a detailed comparison of rotavirus strains circulating pre- and postvaccine introduction. G1P[8] rotaviruses are the most prominent genotype in humans, and a total of 157 G1P[8] rotaviruses isolated between 1999 and 2011 were selected from Belgium and Australia and their complete genomes were sequenced. Phylogenetic analysis showed evidence of frequent reassortment among Belgian and Australian G1P[8] rotaviruses. Although many different phylogenetic subclusters were present before and after vaccine introduction, some unique clusters were only identified after vaccine introduction, which could be due to natural fluctuation or the first signs of vaccine-driven evolution. The times to the most recent common ancestors for the Belgian and Australian G1P[8] rotaviruses ranged from 1846 to 1955 depending on the gene segment, with VP7 and NSP4 resulting in the most recent estimates. We found no evidence that rotavirus population size was affected after vaccine introduction and only six amino acid sites in VP2, VP3, VP7, and NSP1 were identified to be under positive selective pressure. Continued surveillance of G1P[8] strains is needed to determine long-term effects of vaccine introductions, particularly now rotavirus vaccines are implemented in the national immunization programs of an increasing number of countries worldwide. PMID:26254487

  2. Valutazione economica dello studio CARDS: un aggiornamento

    Directory of Open Access Journals (Sweden)

    Simona de Portu

    2011-05-01

    clinical trial evaluating efficacy of atorvastatin versus placebo in preventing the occurrence of cardiovascular events in a cohort of type II diabetes patients without previous history of coronary events. A cost-effectiveness analysis in the perspective of the National Healthcare System (SSN has been performed, under the hypothesis of the imminent price reduction of atorvastatin, due to the loss of exclusivity. Results: after a median follow up of 3.9 years, the number of patients with at least a major cardiovascular event requiring hospitalization was lower in the atorvastatin arm (5.8% compared to the placebo arm (9.0%; p=0.001. Based on a cohort of 1,000 patients, treatment with atorvastatin permitted to gain 29.28 life years. The incremental cost of adding atorvastatin to the standard therapy amounted to €305,682, and was partially balanced by a cost reduction due to fewer hospitalizations, compared to the placebo arm (€ 168,313. Total direct costs were of €602.186 in the atorvastatin group and of € 464,818 in the placebo group, resulting into an incremental cost-effectiveness ratio of € 4,692 for Life Year Gained (LYG. Conclusion: the present study is an update of a previous economic analysis of the CARDS trial. Under the assumed new cost scenario, the cost-effectiveness profile of treating diabetic patients with atorvastatin becomes highly favourable, and leads to a significant reduction of the cost for Life Year Gained compared to the previous findings.

  3. RECORD OF THE BINARY DATA ON SD CARD ARDUINO DUE

    Directory of Open Access Journals (Sweden)

    V. G. Mikhailov

    2016-01-01

    Full Text Available The short review of microcontrollers of family Arduino, their characteristics and application fields is given. Importance of record of parameters of researched object is marked to produce debugging of control systems on microcontrollers Arduino. Unique possibility of registration of parameters in family Arduino is record on SD a card in an alpha mode with usage of functions print (, write (. The problems connected to record of the binary data on SD a card on microcontroller Arduino Due are considered. The analysis of methods of record of the binary data on SD card Arduino Due, originating problems with neo-cleaning of memory from the previous program leading to possibility of duplication of the data on SD to a card, presence of the erratic point of view about restriction of volumes of data record and necessity of usage become outdated SD cards is carried out. Ways of elimination of the marked lacks are considered. The estimation of high-speed performance of various approaches of a data recording on SD a card is led. On the basis of the led researches the approach of multiplexing of the writeable information at the expense of conversion of the binary data is offered is byte-serial in a character array in code ASCI without magnification of their volume and record by units on 240 byte. It allows to use as much as possible standard function possibilities write ( Arduino and specificity of the organization of memory SD of cards and to increase high-speed performance more than in 1100 times in comparison with record in a character type on one byte.It is marked that usage of decisions of an exception of duplication of the data offered at forums does not provide completeness of their elimination. For Arduino Due for storage cleaning it is necessary usages of the special programmator or setting of the new program of loading.

  4. Crystal Structures of Glycosyltransferase UGT78G1 Reveal the Molecular Basis for Glycosylation and Deglycosylation of (Iso)flavonoids

    Energy Technology Data Exchange (ETDEWEB)

    Modolo, Luzia V.; Li, Lenong; Pan, Haiyun; Blount, Jack W.; Dixon, Richard A.; Wang, Xiaoqiang; (SRNF)

    2010-09-21

    The glycosyltransferase UGT78G1 from Medicago truncatula catalyzes the glycosylation of various (iso)flavonoids such as the flavonols kaempferol and myricetin, the isoflavone formononetin, and the anthocyanidins pelargonidin and cyanidin. It also catalyzes a reverse reaction to remove the sugar moiety from glycosides. The structures of UGT78G1 bound with uridine diphosphate or with both uridine diphosphate and myricetin were determined at 2.1 {angstrom} resolution, revealing detailed interactions between the enzyme and substrates/products and suggesting a distinct binding mode for the acceptor/product. Comparative structural analysis and mutagenesis identify glutamate 192 as a key amino acid for the reverse reaction. This information provides a basis for enzyme engineering to manipulate substrate specificity and to design effective biocatalysts with glycosylation and/or deglycosylation activity.

  5. Evolutionarily conserved transcription factor Apontic controls the G1/S progression by inducing cyclin e during eye development

    KAUST Repository

    Liu, Qingxin

    2014-06-16

    During Drosophila eye development, differentiation initiates in the posterior region of the eye disk and progresses anteriorly as a wave marked by the morphogenetic furrow (MF), which demarcates the boundary between anterior undifferentiated cells and posterior differentiated photoreceptors. However, the mechanism underlying the regulation of gene expression immediately before the onset of differentiation remains unclear. Here, we show that Apontic (Apt), which is an evolutionarily conserved transcription factor, is expressed in the differentiating cells posterior to the MF. Moreover, it directly induces the expression of cyclin E and is also required for the G1-to-S phase transition, which is known to be essential for the initiation of cell differentiation at the MF. These observations identify a pathway crucial for eye development, governed by a mechanism in which Cyclin E promotes the G1-to-S phase transition when regulated by Apt.

  6. Molecular characterization of cystic echinococcosis: First record of G7 in Egypt and G1 in Yemen.

    Science.gov (United States)

    Alam-Eldin, Yosra H; Abdel Aaty, Heba E; Ahmed, Mona A

    2015-12-01

    Few molecular studies have identified the current status of cystic echinococcosis in Egypt. The present study aimed to ascertain the genotype(s) of Echinococcus granulosus responsible for human hydatidosis in different Egyptian governorates (regions). Animal isolates were collected from 40 camels, 5 pigs and 44 sheep. 27 human isolates were included in the present study. Specific PCR was performed and followed by DNA sequencing for mitochondrial 12S ribosomal RNA gene and BLAST analysis.The sheep cysts were not hydatid cysts. G6 genotype (camel starin) predominates in human, camel and pig isolates. G7 genotype (pig strain) was detected in two human isolates and one pig isolate. G1 genotype (sheep strain) was detected in one human isolate from Yemen and in no animal isolates. This is the first record of G7 in Egypt and G1 in Yemen.

  7. TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells

    DEFF Research Database (Denmark)

    Pedersen, Rune Troelsgaard; Kruse, Thomas; Nilsson, Jakob

    2015-01-01

    mitotic entry. In early mitosis, TopBP1 marks sites of and promotes unscheduled DNA synthesis. Moreover, TopBP1 is required for focus formation of the structure-selective nuclease and scaffold protein SLX4 in mitosis. Persistent TopBP1 foci transition into 53BP1 nuclear bodies (NBs) in G1 and precise...... temporal depletion of TopBP1 just before mitotic entry induced formation of 53BP1 NBs in the next cell cycle, showing that TopBP1 acts to reduce transmission of DNA damage to G1 daughter cells. Based on these results, we propose that TopBP1 maintains genome integrity in mitosis by controlling chromatin...

  8. Reassortment of Human and Animal Rotavirus Gene Segments in Emerging DS-1-Like G1P[8] Rotavirus Strains.

    Science.gov (United States)

    Komoto, Satoshi; Tacharoenmuang, Ratana; Guntapong, Ratigorn; Ide, Tomihiko; Tsuji, Takao; Yoshikawa, Tetsushi; Tharmaphornpilas, Piyanit; Sangkitporn, Somchai; Taniguchi, Koki

    2016-01-01

    The emergence and rapid spread of novel DS-1-like G1P[8] human rotaviruses in Japan were recently reported. More recently, such intergenogroup reassortant strains were identified in Thailand, implying the ongoing spread of unusual rotavirus strains in Asia. During rotavirus surveillance in Thailand, three DS-1-like intergenogroup reassortant strains having G3P[8] (RVA/Human-wt/THA/SKT-281/2013/G3P[8] and RVA/Human-wt/THA/SKT-289/2013/G3P[8]) and G2P[8] (RVA/Human-wt/THA/LS-04/2013/G2P[8]) genotypes were identified in fecal samples from hospitalized children with acute gastroenteritis. In this study, we sequenced and characterized the complete genomes of strains SKT-281, SKT-289, and LS-04. On whole genomic analysis, all three strains exhibited unique genotype constellations including both genogroup 1 and 2 genes: G3-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2 for strains SKT-281 and SKT-289, and G2-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2 for strain LS-04. Except for the G genotype, the unique genotype constellation of the three strains (P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2) is commonly shared with DS-1-like G1P[8] strains. On phylogenetic analysis, nine of the 11 genes of strains SKT-281 and SKT-289 (VP4, VP6, VP1-3, NSP1-3, and NSP5) appeared to have originated from DS-1-like G1P[8] strains, while the remaining VP7 and NSP4 genes appeared to be of equine and bovine origin, respectively. Thus, strains SKT-281 and SKT-289 appeared to be reassortant strains as to DS-1-like G1P[8], animal-derived human, and/or animal rotaviruses. On the other hand, seven of the 11 genes of strain LS-04 (VP7, VP6, VP1, VP3, and NSP3-5) appeared to have originated from locally circulating DS-1-like G2P[4] human rotaviruses, while three genes (VP4, VP2, and NSP1) were assumed to be derived from DS-1-like G1P[8] strains. Notably, the remaining NSP2 gene of strain LS-04 appeared to be of bovine origin. Thus, strain LS-04 was assumed to be a multiple reassortment strain as to DS-1-like G1P[8], locally circulating

  9. Reassortment of Human and Animal Rotavirus Gene Segments in Emerging DS-1-Like G1P[8] Rotavirus Strains.

    Directory of Open Access Journals (Sweden)

    Satoshi Komoto

    Full Text Available The emergence and rapid spread of novel DS-1-like G1P[8] human rotaviruses in Japan were recently reported. More recently, such intergenogroup reassortant strains were identified in Thailand, implying the ongoing spread of unusual rotavirus strains in Asia. During rotavirus surveillance in Thailand, three DS-1-like intergenogroup reassortant strains having G3P[8] (RVA/Human-wt/THA/SKT-281/2013/G3P[8] and RVA/Human-wt/THA/SKT-289/2013/G3P[8] and G2P[8] (RVA/Human-wt/THA/LS-04/2013/G2P[8] genotypes were identified in fecal samples from hospitalized children with acute gastroenteritis. In this study, we sequenced and characterized the complete genomes of strains SKT-281, SKT-289, and LS-04. On whole genomic analysis, all three strains exhibited unique genotype constellations including both genogroup 1 and 2 genes: G3-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2 for strains SKT-281 and SKT-289, and G2-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2 for strain LS-04. Except for the G genotype, the unique genotype constellation of the three strains (P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2 is commonly shared with DS-1-like G1P[8] strains. On phylogenetic analysis, nine of the 11 genes of strains SKT-281 and SKT-289 (VP4, VP6, VP1-3, NSP1-3, and NSP5 appeared to have originated from DS-1-like G1P[8] strains, while the remaining VP7 and NSP4 genes appeared to be of equine and bovine origin, respectively. Thus, strains SKT-281 and SKT-289 appeared to be reassortant strains as to DS-1-like G1P[8], animal-derived human, and/or animal rotaviruses. On the other hand, seven of the 11 genes of strain LS-04 (VP7, VP6, VP1, VP3, and NSP3-5 appeared to have originated from locally circulating DS-1-like G2P[4] human rotaviruses, while three genes (VP4, VP2, and NSP1 were assumed to be derived from DS-1-like G1P[8] strains. Notably, the remaining NSP2 gene of strain LS-04 appeared to be of bovine origin. Thus, strain LS-04 was assumed to be a multiple reassortment strain as to DS-1-like G1P[8], locally

  10. Lab on paper: iodometric titration on a printed card.

    Science.gov (United States)

    Myers, Nicholas M; Kernisan, Emalee N; Lieberman, Marya

    2015-04-07

    A paper test card has been engineered to perform an iodometric titration, an application that requires storage and mixing on demand of several mutually incompatible reagents. The titration is activated when a user applies a test solution to the test card: the dried reagents are reconstituted and combined through a surface-tension-enabled mixing (STEM) mechanism. The device quantifies 0.8-15 ppm of iodine atoms from iodate in aqueous solutions. This is useful, for example, to quantify iodine levels in fortified salt. A blinded internal laboratory validation established the accuracy as 1.4 ppm I and the precision as 0.9 ppm I when the test card was read by newly trained users. Using computer software to process images, the accuracy and precision both improved to 0.9 ppm I. The paper card can also detect substandard β lactam antibiotics using an iodometric back-titration. When used to quantify amoxicillin, good distinction is achieved between solutions that differ by 0.15 mg/mL over a working range of 0-0.9 mg/mL. The test card was designed to meet the World Health Organization ASSURED criteria for use in low resource settings, where laboratory-based analytical procedures are often not available.

  11. 3D multiplayer virtual pets game using Google Card Board

    Science.gov (United States)

    Herumurti, Darlis; Riskahadi, Dimas; Kuswardayan, Imam

    2017-08-01

    Virtual Reality (VR) is a technology which allows user to interact with the virtual environment. This virtual environment is generated and simulated by computer. This technology can make user feel the sensation when they are in the virtual environment. The VR technology provides real virtual environment view for user and it is not viewed from screen. But it needs another additional device to show the view of virtual environment. This device is known as Head Mounted Device (HMD). Oculust Rift and Microsoft Hololens are the most famous HMD devices used in VR. And in 2014, Google Card Board was introduced at Google I/O developers conference. Google Card Board is VR platform which allows user to enjoy the VR with simple and cheap way. In this research, we explore Google Card Board to develop simulation game of raising pet. The Google Card Board is used to create view for the VR environment. The view and control in VR environment is built using Unity game engine. And the simulation process is designed using Finite State Machine (FSM). This FSM can help to design the process clearly. So the simulation process can describe the simulation of raising pet well. Raising pet is fun activity. But sometimes, there are many conditions which cause raising pet become difficult to do, i.e. environment condition, disease, high cost, etc. this research aims to explore and implement Google Card Board in simulation of raising pet.

  12. Registro de paro cardíaco en el adulto

    Directory of Open Access Journals (Sweden)

    Ricardo Navarro Vargas

    2005-07-01

    Full Text Available En nuestro país no hay un registro estandarizado de los eventos cardíacos que requieren reanimación cerebro-cardio-pulmonar (RCCP siguiendo los lineamientos "Utstein". El propósito de este estudio fue determinar la calidad de los registros extrahospitalarios de paro cardíaco en el adulto, en Bogotá-Colombia. Entre enero y marzo de 2005 se realizó un análisis retrospectivo de los casos que correspondieron a paro cardíaco en el adulto atendidos por el "Centro Regulador de Urgencias del Distrito (CRU". El estudio reveló un registro deficiente de los eventos que requirieron RCCP realizados a nivel prehospitalario, e identificó al trauma como causa de paro cardíaco en 22% de los casos, una cifra particularmente elevada si se compara con los reportes mundiales, que oscilan entre 5% y 8%. Recomienda la estandarización del registro de paro cardíaco en el adulto, para lo cual se sugiere utilizar el formato de registro que sigue los lineamientos "Utstein".

  13. Bah humbug: Unexpected Christmas cards and the reciprocity norm.

    Science.gov (United States)

    Meier, Brian P

    2016-01-01

    The reciprocity norm refers to the expectation that people will help those who helped them. A well-known study revealed that the norm is strong with Christmas cards, with 20% of people reciprocating a Christmas card received from a stranger. I attempted to conceptually replicate and extend this effect. In Study 1, 755 participants received a Christmas card supposedly from a more- versus less-similar stranger. The reciprocation rate was unexpectedly low (2%), which did not allow for a test of a similarity effect. Two potential reasons for this low rate were examined in Study 2 in which 494 participants reported their likelihood of reciprocating a Christmas card from a stranger as well as their felt suspicions/threat about the card and their frequency of e-mail use. Reciprocation likelihood was negatively correlated with perceived threat/suspicion and e-mail use. It appears that reciprocating a gift from a stranger in offline settings may be less likely than expected.

  14. Biometric authentication for ID cards with hologram watermarks

    Science.gov (United States)

    Croce Ferri, Lucilla; Mayerhoefer, Astrid; Frank, Marcus; Vielhauer, Claus; Steinmetz, Ralf

    2002-04-01

    We present an analysis of a new technique for the authentication of ID cardholders, based on the integration of a biometrics-based authentication system with digital watermarks. The chosen biometric authentication method is the dynamic signature verification of the ID cardholder, while we use a specific integrity watermark technique we developed, called Hologram Watermark, to embed and retrieve the off-line data onto an ID card. We take advantage of the fact, that two static biometric features (images of the user's face and signature) are already integral part of ID cards for manual verification and extent the stored biometric information by embedding on-line handwriting features of the signature as holographic watermarks in the overall image information of an ID card. Manipulation of any of the image information can be detected and will further disallow biometric verification of the forger. The Hologram Watermark technique produces content-related data using computer-generated hologram coding techniques. These data are embedded with watermarking techniques into the personal data printed on an ID card. The content-related data in this specific application are the dynamic features of the cardholder's signature. The main goal of this paper is to analyze the suitability of dynamic signature verification in combination with the Hologram Watermark technique, to facilitate automated user authentication based on information transparently embedded in ID cards.

  15. REMINDER - FRENCH CARDS - NEW PROCEDURE FOR INITIAL APPLICATION

    CERN Document Server

    Human Resources Division

    2002-01-01

    The Human Resources Division would like to remind members of personnel that they are obliged to submit an application form for a French card as soon as they have a permanent address in either Switzerland or in France and they are actually living there. Following the rationalization of our administrative procedures, as of October 1st, 2002, the initial application procedure for a French card will now be as follows: The member of personnel should complete an application form. If necessary, an application form must also be completed for family members. These forms must then be transferred via e-mail to the appropriate Divisional Administrative Officer (DAO) who will forward them to the Cards Service. In parallel, the member of personnel should submit the necessary supporting documents to the Cards Service. Users are requested to apply for a French card through the Users' Office. The application form (Word format only), the procedural details, the necessary supporting documents as well as the conditions of issue ...

  16. On the Steady-State System Size Distribution for a Discrete-Time Geo/G/1 Repairable Queue

    Directory of Open Access Journals (Sweden)

    Renbin Liu

    2014-01-01

    Full Text Available This paper studies a discrete-time N-policy Geo/G/1 queueing system with feedback and repairable server. With a probabilistic analysis method and renewal process theory, the steady-state system size distribution is derived. Further, the steady-state system size distribution derived in this work is extremely suitable for numerical calculations. Numerical example illustrates the important application of steady-state system size distribution in system capacity design for a network access proxy system.

  17. Selective Subnormal IgG1 in 54 Adult Index Patients with Frequent or Severe Bacterial Respiratory Tract Infections.

    Science.gov (United States)

    Barton, James C; Bertoli, Luigi F; Barton, J Clayborn; Acton, Ronald T

    2016-01-01

    We characterized 54 adult index patients with reports of frequent or severe bacterial respiratory tract infections at diagnosis of selective subnormal IgG1. Mean age was 50 ± 13 (SD) y; 87.0% were women. Associated disorders included the following: autoimmune conditions 50.0%; hypothyroidism 24.1%; atopy 38.9%; and other allergy 31.5%. In 35.5%, proportions of protective S. pneumoniae serotype-specific IgG levels did not increase after polyvalent pneumococcal polysaccharide vaccination (PPPV). Blood lymphocyte subset levels were within reference limits in most patients. Regressions on IgG1 and IgG3 revealed no significant association with age, sex, autoimmune conditions, hypothyroidism, atopy, other allergy, corticosteroid therapy, or lymphocyte subsets. Regression on IgG2 revealed significant associations with PPPV response (negative) and CD19+ lymphocytes (positive). Regression on IgG4 revealed significant positive associations with episodic corticosteroid use and IgA. Regression on IgA revealed positive associations with IgG2 and IgG4. Regression on IgM revealed negative associations with CD56+/CD16+ lymphocytes. Regressions on categories of infection revealed a negative association of urinary tract infections and IgG1. HLA-A(⁎)03, HLA-B(⁎)55 and HLA-A(⁎)24, HLA-B(⁎)35 haplotype frequencies were greater in 38 patients than 751 controls. We conclude that nonprotective S. pneumoniae IgG levels and atopy contribute to increased susceptibility to respiratory tract infections in patients with selective subnormal IgG1.

  18. Detailed petrographic descriptions and microprobe data for tertiary silicic volcanic rocks in drill hole USW G-1, Yucca Mountain, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Caporuscio, F.A.; Warren, R.G.; Broxton, D.E.

    1985-12-01

    This report contains detailed petrographic descriptions of 74 thin sections from drill hole USW G-1 at Yucca Mountain, Nevada. These descriptions are keyed to the distinctions between devitrified, vitrophyre, vitric, and zeolitized intervals below the Topopah Spring Member repository horizon. The petrographic features of the zeolitized intervals down through the Crater Flat tuff, as well as the sorption properties determined from these intervals, suggest that these zeolite occurrences may each have comparable sorptive capability.

  19. MKP1 phosphatase mediates G1-specific dephosphorylation of H3Serine10P in response to DNA damage

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, Ajit K.; Khan, Shafqat A.; Sharda, Asmita; Reddy, Divya V; Gupta, Sanjay, E-mail: sgupta@actrec.gov.in

    2015-08-15

    Highlights: • Reversible reduction of H3S10 phosphorylation after DNA damage is G1 phase specific. • Dynamic balance between MAP kinases, MKP1 and MSK1 regulate H3S10P during DDR. • MKP1 associates with chromatin bearing γH2AX in response to DNA damage. • Inhibition of MKP1 activity with specific inhibitor promotes radiation-induced cell death. - Abstract: Histone mark, H3S10 phosphorylation plays a dual role in a cell by maintaining relaxed chromatin for active transcription in interphase and condensed chromatin state in mitosis. The level of H3S10P has also been shown to alter on DNA damage; however, its cell cycle specific behavior and regulation during DNA damage response is largely unexplored. In the present study, we demonstrate G1 cell cycle phase specific reversible loss of H3S10P in response to IR-induced DNA damage is mediated by opposing activities of phosphatase, MKP1 and kinase, MSK1 of the MAP kinase pathway. We also show that the MKP1 recruits to the chromatin in response to DNA damage and correlates with the decrease of H3S10P, whereas MKP1 is released from chromatin during recovery phase of DDR. Furthermore, blocking of H3S10 dephosphorylation by MKP1 inhibition impairs DNA repair process and results in poor survival of WRL68 cells. Collectively, our data proposes a pathway regulating G1 cell cycle phase specific reversible reduction of H3S10P on IR induced DNA damage and also raises the possibility of combinatorial modulation of H3S10P with specific inhibitors to target the cancer cells in G1-phase of cell cycle.

  20. In vitro glycoengineering of IgG1 and its effect on Fc receptor binding and ADCC activity.

    Directory of Open Access Journals (Sweden)

    Marco Thomann

    Full Text Available The importance and effect of Fc glycosylation of monoclonal antibodies with regard to biological activity is widely discussed and has been investigated in numerous studies. Fc glycosylation of monoclonal antibodies from current production systems is subject to batch-to-batch variability. If there are glycosylation changes between different batches, these changes are observed not only for one but multiple glycan species. Therefore, studying the effect of distinct Fc glycan species such as galactosylated and sialylated structures is challenging due to the lack of well-defined differences in glycan patterns of samples used. In this study, the influence of IgG1 Fc galactosylation and sialylation on its effector functions has been investigated using five different samples which were produced from one single drug substance batch by in vitro glycoengineering. This sample set comprises preparations with minimal and maximal galactosylation and different levels of sialylation of fully galactosylated Fc glycans. Among others, Roche developed the glycosyltransferase enzyme sialyltransferase which was used for the in vitro glycoengineering activities at medium scale. A variety of analytical assays, including Surface Plasmon Resonance and recently developed FcγR affinity chromatography, as well as an optimized cell-based ADCC assay were applied to investigate the effect of Fc galactosylation and sialylation on the in vitro FcγRI, IIa, and IIIa receptor binding and ADCC activity of IgG1. The results of our studies do not show an impact, neither positive nor negative, of sialic acid- containing Fc glycans of IgG1 on ADCC activity, FcγRI, and RIIIa receptors, but a slightly improved binding to FcγRIIa. Furthermore, we demonstrate a galactosylation-induced positive impact on the binding activity of the IgG1 to FcγRIIa and FcγRIIIa receptors and ADCC activity.

  1. Singularity-conquering ZG controllers of z2g1 type for tracking control of the IPC system

    Science.gov (United States)

    Zhang, Yunong; Yu, Xiaotian; Yin, Yonghua; Peng, Chen; Fan, Zhengping

    2014-09-01

    With wider investigations and applications of autonomous robotics and intelligent vehicles, the inverted pendulum on a cart (IPC) system has become more attractive for numerous researchers due to its concise and representative structure. In this article, the tracking-control problem of the IPC system is considered and investigated. Based on Zhang dynamics (ZD) and gradient dynamics (GD), a novel kind of ZG controllers are developed and investigated for achieving the tracking-control purpose, which contains controllers of z2g0 and z2g1 types according to the number of times of using the ZD and GD methods. Besides, theoretical analyses are presented to guarantee the global and exponential convergence performance of both z2g0 and z2g1 controllers. Computer simulations are further performed to substantiate the feasibility and effectiveness of ZG controllers. More importantly, comparative simulation results demonstrate that controllers of z2g1 type can conquer the singularity problem (i.e. the division-by-zero problem).

  2. Performance of a newly isolated salt-tolerant yeast strain Pichia occidentalis G1 for degrading and detoxifying azo dyes.

    Science.gov (United States)

    Song, Li; Shao, Yifan; Ning, Shuxiang; Tan, Liang

    2017-06-01

    A salt-tolerant yeast named G1 which could decolorize various azo dyes was recently isolated and identified as Pichia occidentalis. Systematic researches on characterization, degradation pathway, detoxification effects and enzymes analysis of this yeast were done. The results showed that the optimal metabolism and growth parameters for strain G1 were: 2.0gL-1 glucose, 0.6gL-1 ammonium sulfate, 0.08gL-1 yeast extract, 30gL-1 NaCl, 160rmin-1, 30°C and pH 5.0. More than 98% of 50mgL-1 Acid Red B (ARB) could be decolorized within 16h under the optimal conditions. Additionally, strain G1 degraded and obviously detoxified ARB through a possible pathway successively consisting of decolorization, deamination/desulfonation and TCA cycle processes. Moreover, NADH-DCIP reductase was estimated as the key reductase for decolorization and ligninases including lignin peroxidase, manganese peroxidase and laccase were important oxidoreductases for further degradation of decolorization intermediates. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. The Spin-dependent Structure Function of the Proton $g_{1}^p$ and a Test of the Bjorken Sum Rule

    CERN Document Server

    Alekseev, M.G.; Alexandrov, Yu.; Alexeev, G.D.; Amoroso, A.; Austregesilo, A.; Badelek, B.; Balestra, F.; Ball, J.; Barth, J.; Baum, G.; Bedfer, Y.; Bernhard, J.; Bertini, R.; Bettinelli, M.; Birsa, R.; Bisplinghoff, J.; Bordalo, P.; Bradamante, F.; Bravar, A.; Bressan, A.; Brona, G.; Burtin, E.; Bussa, M.P.; Chaberny, D.; Cotic, D.; Chiosso, M.; Chung, S.U.; Cicuttin, A.; Colantoni, M.; Crespo, M.L.; Dalla Torre, S.; Das, S.; Dasgupta, S.S.; Denisov, O.Yu.; Dhara, L.; Diaz, V.; Donskov, S.V.; Doshita, N.; Duic, V.; Dunnweber, W.; Efremov, A.; El Alaoui, A.; Eversheim, P.D.; Eyrich, W.; Faessler, M.; Ferrero, A.; Filin, A.; Finger, M.; Finger, M., Jr.; Fischer, H.; Franco, C.; Friedrich, J.M.; Garfagnini, R.; Gautheron, F.; Gavrichtchouk, O.P.; Gazda, R.; Gerassimov, S.; Geyer, R.; Giorgi, M.; Gnesi, I.; Gobbo, B.; Goertz, S.; Grabmuller, S.; Grasso, A.; Grube, B.; Gushterski, R.; Guskov, A.; Haas, F.; von Harrach, D.; Hasegawa, T.; Heinsius, F.H.; Hermann, R.; Herrmann, F.; Hess, C.; Hinterberger, F.; Horikawa, N.; Hoppner, Ch.; d'Hose, N.; Ilgner, C.; Ishimoto, S.; Ivanov, O.; Ivanshin, Yu.; Iwata, T.; Jahn, R.; Jasinski, P.; Jegou, G.; Joosten, R.; Kabuss, E.; Kafer, W.; Kang, D.; Ketzer, B.; Khaustov, G.V.; Khokhlov, Yu.A.; Kisselev, Yu.; Klein, F.; Klimaszewski, K.; Koblitz, S.; Koivuniemi, J.H.; Kolosov, V.N.; Kondo, K.; Konigsmann, K.; Konopka, R.; Konorov, I.; Konstantinov, V.F.; Korzenev, A.; Kotzinian, A.M.; Kouznetsov, O.; Kowalik, K.; Kramer, M.; Kral, A.; Kroumchtein, Z.V.; Kuhn, R.; Kunne, F.; Kurek, K.; Lauser, L.; Le Goff, J.M.; Lednev, A.A.; Lehmann, A.; Levorato, S.; Lichtenstadt, J.; Liska, T.; Maggiora, A.; Maggiora, M.; Magnon, A.; Mallot, G.K.; Mann, A.; Marchand, C.; Marroncle, J.; Martin, A.; Marzec, J.; Massmann, F.; Matsuda, T.; Maximov, A.N.; Meyer, W.; Michigami, T.; Mikhailov, Yu.V.; Moinester, M.A.; Mutter, A.; Nagaytsev, A.; Nagel, T.; Nassalski, J.; Negrini, T.; Nerling, F.; Neubert, S.; Neyret, D.; Nikolaenko, V.I.; Nunes, A.S.; Olshevsky, A.G.; Ostrick, M.; Padee, A.; Panknin, R.; Panzieri, D.; Parsamyan, B.; Paul, S.; Pawlukiewicz-Kaminska, B.; Perevalova, E.; Pesaro, G.; Peshekhonov, D.V.; Piragino, G.; Platchkov, S.; Pochodzalla, J.; Polak, J.; Polyakov, V.A.; Pontecorvo, G.; Pretz, J.; Quintans, C.; Rajotte, J.F.; Ramos, S.; Rapatsky, V.; Reicherz, G.; Richter, A.; Robinet, F.; Rocco, E.; Rondio, E.; Ryabchikov, D.I.; Samoylenko, V.D.; Sandacz, A.; Santos, H.; Sapozhnikov, M.G.; Sarkar, S.; Savin, I.A.; Sbrizzai, G.; Schiavon, P.; Schill, C.; Schmitt, L.; Schluter, T.; Schopferer, S.; Schroder, W.; Shevchenko, O.Yu.; Siebert, H.W.; Silva, L.; Sinha, L.; Sissakian, A.N.; Slunecka, M.; Smirnov, G.I.; Sosio, S.; Sozzi, F.; Srnka, A.; Stolarski, M.; Sulc, M.; Sulej, R.; Takekawa, S.; Tessaro, S.; Tessarotto, F.; Teufel, A.; Tkatchev, L.G.; Uhl, S.; Uman, I.; Virius, M.; Vlassov, N.V.; Vossen, A.; Weitzel, Q.; Windmolders, R.; Wislicki, W.; Wollny, H.; Zaremba, K.; Zavertyaev, M.; Zemlyanichkina, E.; Ziembicki, M.; Zhao, J.; Zhuravlev, N.; Zvyagin, A.

    2010-01-01

    The inclusive double-spin asymmetry, $A_{1}^{p}$, has been measured at COMPASS in deepinelastic polarised muon scattering off a large polarised NH3 target. The data, collected in the year 2007, cover the range Q2 > 1 (GeV/c)^2, 0.004 < x < 0.7 and improve the statistical precision of g_{1}^{p}(x) by a factor of two in the region x < 0.02. The new proton asymmetries are combined with those previously published for the deuteron to extract the non-singlet spin-dependent structure function g_1^NS(x,Q2). The isovector quark density, Delta_q_3(x,Q2), is evaluated from a NLO QCD fit of g_1^NS. The first moment of Delta_q3 is in good agreement with the value predicted by the Bjorken sum rule and corresponds to a ratio of the axial and vector coupling constants g_A/g_V = 1.28+-0.07(stat)+-0.10(syst).

  4. Sex of respondent and credit attitudes as predictors of credit card use and debt payment.

    Science.gov (United States)

    McCall, Michael; Eckrich, Donald W

    2006-06-01

    Researchers have suggested there may be sex differences in attitudes towards credit card possession and use. Undergraduates, 41 men and 41 women, completed a survey regarding their attitudes towards credit, credit card use, and repayment. Analysis indicated sex played a significant moderating role between number of credit cards used and the importance of paying off monthly balances. Women possessed more credit cards than men and engaged in more frequent shopping. Number of credit cards increased with paying off of monthly balances. Data are discussed in terms of the importance of managing credit card debt in an increasingly cashless society.

  5. SISTEM TERPADU REKAM MEDIK RUMAH SAKIT DENGAN SMART CARD

    Directory of Open Access Journals (Sweden)

    _ Sukamto

    2013-04-01

    Full Text Available Dalam penelitian ini,  system terpadu rekam medik rumah sakit dibuat dengan teknologi smart card sebagai media penimpanan data  Tujuan dari penelitian ini adalah  menerapkan teknologi smart card sebagai sarana  atau media penyimpan informasi pasien yang mempunyai kesederhana, keandalan, dan portabilitas  yang tinggi, sehingga meningkatkan jaminan ketersediaan data pada sebuah sistem rekam medik.Tahapan pembuatan rancang bangun sistem rekam medis ini meliputi  perancangan data flow diagram, rentity relationshipp diagram, database dan program aplikasi. Hasil dari penelitian ini menunjukan bahwa smart  card dapat digunakan  sebagai sarana  atau media penyimpan informasi pasien yang mempunyai kesederhana, keandalan, dan portabilitas  yang tinggi.

  6. Christmas cards workshop in a Restricted Access Ward

    Directory of Open Access Journals (Sweden)

    Teresa García

    2003-12-01

    Full Text Available The Christmas cards workshop is an intervention study made in the Restricted Access Ward (RAW of Hospital Gregorio Marañón (Madrid, in December 2001, from the 5th to the 22nd. The object of this study was to assess the effectiveness of this workshop to improve the quality of the RAW patients´ hospital day, through their participation. They made 47 cards, the mean per patient was 1,52. Participation: 91,2% of the patients that fulfilled the inclusion criteria. Drawings and texts alluded to the convict´s perspective of Christmas time, from their own experience. The Christmas cards were exhibited in the hospital and they also were sent to different penitentiary institutions in Madrid, to make the RAW known. The course “Education for health for interdisciplinary projects in penitentiary institutions” was the frame of this workshop.

  7. STANDARDIZATION AND APPLICATION OF PLASTIC CARDS IN THE EDUCATIONAL SYSTEMS

    Directory of Open Access Journals (Sweden)

    Polina V. Baranova

    2015-01-01

    Full Text Available The application of plastic cards has been widely increasing in various fields of life, business and education. They have already become up-to-date and convenient attribute of our daily life. There are emerging more and more areas where they can be used in a convenient and practical way. Contactless smart cards can be used in access control in the educational systems. This article gives an overview of existing standards dealing with contactless identification smart-cards. All standards covered in this article are developed by the Federal State Unitary Enterprise VNIINMASH jointly with TC 22 «Information Technology» based on their own authentic Russian translation of international standards. 

  8. BEHAVIOR BASED CREDIT CARD FRAUD DETECTION USING SUPPORT VECTOR MACHINES

    Directory of Open Access Journals (Sweden)

    V. Dheepa

    2012-07-01

    Full Text Available Along with the great increase of internet and e-commerce, the use of credit card is an unavoidable one. Due to the increase of credit card usage, the frauds associated with this have also increased. There are a lot of approaches used to detect the frauds. In this paper, behavior based classification approach using Support Vector Machines are employed and efficient feature extraction method also adopted. If any discrepancies occur in the behaviors transaction pattern then it is predicted as suspicious and taken for further consideration to find the frauds. Generally credit card fraud detection problem suffers from a large amount of data, which is rectified by the proposed method. Achieving finest accuracy, high fraud catching rate and low false alarms are the main tasks of this approach.

  9. Optimised to Fail: Card Readers for Online Banking

    Science.gov (United States)

    Drimer, Saar; Murdoch, Steven J.; Anderson, Ross

    The Chip Authentication Programme (CAP) has been introduced by banks in Europe to deal with the soaring losses due to online banking fraud. A handheld reader is used together with the customer’s debit card to generate one-time codes for both login and transaction authentication. The CAP protocol is not public, and was rolled out without any public scrutiny. We reverse engineered the UK variant of card readers and smart cards and here provide the first public description of the protocol. We found numerous weaknesses that are due to design errors such as reusing authentication tokens, overloading data semantics, and failing to ensure freshness of responses. The overall strategic error was excessive optimisation. There are also policy implications. The move from signature to PIN for authorising point-of-sale transactions shifted liability from banks to customers; CAP introduces the same problem for online banking. It may also expose customers to physical harm.

  10. PROSEDUR PERMOHONAN SHAR-E CARD PADABANK MUAMALAT

    Directory of Open Access Journals (Sweden)

    Aprilianti Aprilianti

    2015-11-01

    Full Text Available After the economic crisis that followed the liquidation of some national private banks in 1997 gave rise to alternative thinking and measures to develop banking activity based on Islamic principles. Islamic principles reflected in the pattern of bamk operating in accordance with Islamic principles, especially regarding the procedures for bermuamalah in Islam. Shar-E Card is one type of credit card services by a bank Muamalat where the balance is outstanding amounts dengam mudaraba principle that no restriction for banks to use the funds raised, bamk shall memberitahukam to the owner of the funds of the ratios and procedures for the provision of benefits and or the calculation of benefit sharing as well as risks that may arise from the storage of funds. Keywords: Shar-E Card, Bank Muamalat

  11. CLUB FORMATION MECHANISM FOR TRANSPORT-COMMUNITY CREDIT CARDS

    Science.gov (United States)

    Ding, Yue; Kobayashi, Kiyoshi; Nishida, Junji; Yoshida, Mamoru

    In this paper, the roles of transport-community cards jointly issued by a public transport firm and retails are investigated as a means to vitalize an obsolescence shopping center located in a middle of a city. When both the price of goods supplied by the retails and the transport fares affect the consumers' behavior, there exist pecuniary externality between the behaviors of the retails and transport firms. The introduction of a transport-community cards system enables to integrate a basket of goods and transport service into a single commodity; thus, the pecuniary externality can be internalized by price coordination. In addition, the paper clarifies theoretically that the transport firm initiatively decides the price of the transportation service and the retails transfer their incomes to the transport firm so that they are induced to jointly issue the transport-community cards.

  12. An Improvement on Remote User Authentication Schemes Using Smart Cards

    Directory of Open Access Journals (Sweden)

    Chin-Ling Chen

    2018-01-01

    Full Text Available In 2010, Yeh et al. proposed two robust remote user authentication schemes using smart cards; their claims were such that their schemes defended against ID-theft attacks, reply attacks, undetectable on-line password guessing attacks, off-line password guessing attacks, user impersonation attack, server counterfeit attack and man-in-the-middle attack. In this paper, we show that Yeh et al.’s schemes are still vulnerable to ID-theft attack, off-line password guessing attacks, undetectable on-line password guessing attacks and user impersonation attack. Notably, problems remain in situations where the user lost a smart card or the malicious legal user. To remedy these flaws, this paper proposes an improvement on Yeh et al.’s remote user authentication schemes using smart cards.

  13. Consumers' use of internet-based nursing home report cards.

    Science.gov (United States)

    Castle, Nicholas G

    2009-06-01

    Few studies have addressed the extent to which consumers use nursing home report cards and how they use this information. These questions, which are significant because the nursing home market presents several challenges to the effectiveness of report cards, were pursued in a study. Data used in this investigation came from three mail surveys conducted in 2006 of family members of nursing home residents (N = 4,754), family members of assisted-living residents (N = 496), and elders living in high-rise buildings (N = 1,252). Some 31% of family members of nursing home residents, 53% of family members of assisted-living residents, and 23% of elders living in high-rise buildings used the Internet in looking for a nursing home. In general, these different types of consumers look for different types of nursing home information. According to the results, most consumers who used the Internet to look for a nursing home also used a report card. In addition, between 6% and 17% of consumers specifically identified using Nursing Home Compare when looking for a nursing home. The highest use of report cards was reported by family members of assisted-living residents, followed by family members of nursing home residents. Many consumers primarily used the report cards simply to find the location of nursing homes-a useful first step when examining the facility choices available. Yet relatively few consumers primarily used report cards for the arguably more important step of comparing quality information. Future research should investigate why the quality information is not used to a greater extent and what hinders consumers from using this information.

  14. Whole genome microarray analysis, from neonatal blood cards

    Directory of Open Access Journals (Sweden)

    Hogan Michael E

    2009-07-01

    Full Text Available Abstract Background Neonatal blood, obtained from a heel stick and stored dry on paper cards, has been the standard for birth defects screening for 50 years. Such dried blood samples are used, primarily, for analysis of small-molecule analytes. More recently, the DNA complement of such dried blood cards has been used for targeted genetic testing, such as for single nucleotide polymorphism in cystic fibrosis. Expansion of such testing to include polygenic traits, and perhaps whole genome scanning, has been discussed as a formal possibility. However, until now the amount of DNA that might be obtained from such dried blood cards has been limiting, due to inefficient DNA recovery technology. Results A new technology is employed for efficient DNA release from a standard neonatal blood card. Using standard Guthrie cards, stored an average of ten years post-collection, about 1/40th of the air-dried neonatal blood specimen (two 3 mm punches was processed to obtain DNA that was sufficient in mass and quality for direct use in microarray-based whole genome scanning. Using that same DNA release technology, it is also shown that approximately 1/250th of the original purified DNA (about 1 ng could be subjected to whole genome amplification, thus yielding an additional microgram of amplified DNA product. That amplified DNA product was then used in microarray analysis and yielded statistical concordance of 99% or greater to the primary, unamplified DNA sample. Conclusion Together, these data suggest that DNA obtained from less than 10% of a standard neonatal blood specimen, stored dry for several years on a Guthrie card, can support a program of genome-wide neonatal genetic testing.

  15. Spectroscopic Studies on the Characterization of a Persian Playing Card.

    Science.gov (United States)

    Holakooei, Parviz; Niknejad, Maryam; Vaccaro, Carmela

    2016-01-01

    This paper presents the results of our investigations on a playing card preserved at The Mūzih-i Āynih va Rushanāī in Yazd, Iran. Conducting micro X-ray fluorescence spectrometry (μ-XRF), micro-Raman spectroscopy (μ-Raman), infrared reflectography (IRR), ultraviolet fluorescence photography, radiography, and optical microscopy, various paints applied on the playing card were identified. According to our analytical studies, red, green, blue, black, and gold-like metallic paints were identified to be a red monoazo pigment (β-naphthol PR 53:1), chrome green, artificial ultramarine blue, carbon black, and brass powder (Dutch metal powder), respectively, dating the playing card to 1895 onward based on the manufacturing date of the red monoazo pigment. Barite was also shown to be mixed with the pigments as an extender. On the other hand, the portrait's face of the playing card was peculiarly blackened. Our analytical approach toward characterizing the blackened face showed that the black paint was achieved by carbon black and, in other words, the face was not blackened due to the darkening of Pb-bearing pigments. Moreover, it was shown that there was no underdrawing under the black face and the black paint was most probably executed in the same time with the other paints. Considering the possible use of the playing card, it was suggested not to remove the blackened face in the cleaning process since the black paint was a part of the integrity of the playing card. © The Author(s) 2015.

  16. Insuficiencia cardíaca congestiva o cor pulmonale

    OpenAIRE

    Amarís Peña, Óscar Ernesto

    2014-01-01

    La insuficiencia cardíaca es una de las principalescausas de muerte cardiovascular y se presentacomo consecuencia, en más del 70 porciento de los casos, de las dos enfermedadescardiovasculares de mayor prevalencia: lahipertensión arterial y la enfermedad coronaria.La disnea y el edema en los miembros inferioresson los dos criterios más usados para el diagnósticode insuficiencia cardíaca congestiva yestos son, justamente, las principales manifestacionesde los pacientes con Cor Pulmonale.Este d...

  17. Weavy: interactive card-weaving design and construction.

    Science.gov (United States)

    Igarashi, Yuki; Mitani, Jun

    2014-01-01

    Card weaving is a simple, easy weaving method, but designing patterns is typically laborious and requires knowledge, experience, and skill. The Weavy system helps users design and weave original patterns with or without repeating elements. In the latter case, the system automatically considers constraints such as the number of yarn colors and the cards' rotation direction. Following Weavy's construction guide, users weave the pattern they've created. Researchers exhibited Weavy at the ACM Siggraph 2013 Studio and ran a small workshop for children in Japan. In both cases, the participants quickly learned how to use Weavy and enjoyed designing and weaving objects.

  18. Do Consumers Pay More Using Debit Cards than Cash?

    DEFF Research Database (Denmark)

    Runnemark, Emma; Hedman, Jonas; Xiao, Xiao

    We conduct an incentivized experiment to test whether the willingness to pay is higher for debit cards compared to cash for three consumer products. Our findings support this conjecture also after controlling for cash availability, spending type, price familiarity and consumption habits of the pr......We conduct an incentivized experiment to test whether the willingness to pay is higher for debit cards compared to cash for three consumer products. Our findings support this conjecture also after controlling for cash availability, spending type, price familiarity and consumption habits...

  19. Evolution of optically nondestructive and data-non-intrusive credit card verifiers

    Science.gov (United States)

    Sumriddetchkajorn, Sarun; Intaravanne, Yuttana

    2010-04-01

    Since the deployment of the credit card, the number of credit card fraud cases has grown rapidly with a huge amount of loss in millions of US dollars. Instead of asking more information from the credit card's holder or taking risk through payment approval, a nondestructive and data-non-intrusive credit card verifier is highly desirable before transaction begins. In this paper, we review optical techniques that have been proposed and invented in order to make the genuine credit card more distinguishable than the counterfeit credit card. Several optical approaches for the implementation of credit card verifiers are also included. In particular, we highlight our invention on a hyperspectral-imaging based portable credit card verifier structure that offers a very low false error rate of 0.79%. Other key features include low cost, simplicity in design and implementation, no moving part, no need of an additional decoding key, and adaptive learning.

  20. Dispute resolution: the use of arbitration in the credit card industry

    OpenAIRE

    Olivier André

    2009-01-01

    The fine print in most credit card agreements states that any dispute with a credit card issuer must be resolved through arbitration. The author lays out potential advantages and disadvantages for the consumer.