WorldWideScience

Sample records for carbuncle

  1. Carbuncle

    Science.gov (United States)

    ... skin. It may be the size of a pea or as large as a golf ball. The carbuncle may be red and irritated and might hurt when you touch it. It may also: Grow very fast Have a white or yellow center (contain pus ) Weep, ooze, or crust Spread ...

  2. A note on the carbuncle in shallow water simulations

    OpenAIRE

    Kemm, Friedemann

    2012-01-01

    An important problem in gas dynamics simulation is to prevent the carbuncle, a breakdown of discrete shock profiles. We show that for high Froude number, this also occurs in shallow water simulations and give numerical evidence that all cures developed for gas dynamics should also work in shallow water flows.

  3. Situación carbunclo rural en la Argentina 2011 -Condition of rural carbuncle in argentina 2011

    Directory of Open Access Journals (Sweden)

    Noseda, Ramon P.

    2012-04-01

    Full Text Available RESUMENDesde hace 8 años se elabora este informe sobre la Situación Anual del Carbunclo Rural producido por la bacteria esporulada Bacillus anthracis, siendo una zoonosis, enferma a animales y hombres relacionados con la labor ganadera.SUMMARYThis report of the Annual Condition of Rural Carbuncle produced by the spore bacteria Bacillus anthracis has been created every year since 2004. This zoonosis infects animals and people related to cattle labor.

  4. Situación carbunclo rural en la Argentina 2011 -Condition of rural carbuncle in argentina 2011

    OpenAIRE

    Noseda, Ramon P.

    2012-01-01

    RESUMENDesde hace 8 años se elabora este informe sobre la Situación Anual del Carbunclo Rural producido por la bacteria esporulada Bacillus anthracis, siendo una zoonosis, enferma a animales y hombres relacionados con la labor ganadera.SUMMARYThis report of the Annual Condition of Rural Carbuncle produced by the spore bacteria Bacillus anthracis has been created every year since 2004. This zoonosis infects animals and people related to cattle labor.

  5. Skin Rashes and Other Changes

    Science.gov (United States)

    ... painful red bumps? Yes This could be a BOIL. A cluster of boils is called a CARBUNCLE. These occur due to infection under the skin. Gently compress the boil with a warm cloth. Use antibiotic ointments if ...

  6. Drug: D07029 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ine formulations 52 Traditional Chinese medicines 520 Traditional Chinese medicin...es 5200 Traditional Chinese medicines D07029 Hainosankyuto Traditional Chinese Medi...n; Carbuncle; Furuncle Therapeutic category: 5200 Therapeutic category of drugs in Japan [BR:br08301] 5 Crude drugs and Chinese medic

  7. Genome Sequence of Bacillus pumilus Strain Bonn, Isolated from an Anthrax-Like Necrotic Skin Infection Site of a Child

    OpenAIRE

    Grass, Gregor; Bierbaum, Gabriele; Molitor, Ernst; Götte, Natascha; Antwerpen, Markus

    2016-01-01

    We report the draft genome sequence of Bacillus pumilus strain Bonn associated with human skin infection. B. pumilus Bonn was isolated from a carbuncle-like necrotic site, resembling cutaneous anthrax, on the back of the hand of a 10-year-old child.

  8. Genome Sequence of Bacillus pumilus Strain Bonn, Isolated from an Anthrax-Like Necrotic Skin Infection Site of a Child.

    Science.gov (United States)

    Grass, Gregor; Bierbaum, Gabriele; Molitor, Ernst; Götte, Natascha; Antwerpen, Markus

    2016-01-01

    We report the draft genome sequence of Bacillus pumilus strain Bonn associated with human skin infection. B. pumilus Bonn was isolated from a carbuncle-like necrotic site, resembling cutaneous anthrax, on the back of the hand of a 10-year-old child. PMID:26868410

  9. Anti-inflammatory effects, nuclear magnetic resonance identification, and high-performance liquid chromatography isolation of the total flavonoids from Artemisia frigida

    OpenAIRE

    Qinghu Wang; Jinmei Jin; Nayintai Dai; Narenchaoketu Han; Jingjing Han; Baiyinmuqier Bao

    2016-01-01

    The aerial parts of Artemisia frigida Willd. are used to treat joint swelling, renal heat, abnormal menstruation, and sore carbuncle. The anti-inflammatory effects of A. frigida have been well-known in folk medicine, suggesting that components extracted from A. frigida could potentially treat inflammatory disease. With the aim of discovering bioactive compounds, in this study, we extracted total flavonoids from the aerial parts of A. frigida and investigated their anti-inflammatory effects ag...

  10. A Note on the Convergence of the Godunov Method for Impact Problems

    OpenAIRE

    Banks, J. W.

    2012-01-01

    This paper identifies a new pathology that can be found for numerical simulations of nonlinear conservation law systems. Many of the difficulties already identified in the literature (rarefaction shocks, carbuncle phenomena, slowly moving shocks, wall heating, etc) can be traced to insufficient numerical dissipation, and the current case is no different. However, the details of the case we study here are somewhat unique in that the solution which is found by the numerics is very weak and can ...

  11. Gas Evolution Dynamics in Godunov-Type Schemes and Analysis of Numerical Shock Instability

    Science.gov (United States)

    Xu, Kun

    1999-01-01

    In this paper we are going to study the gas evolution dynamics of the exact and approximate Riemann solvers, e.g., the Flux Vector Splitting (FVS) and the Flux Difference Splitting (FDS) schemes. Since the FVS scheme and the Kinetic Flux Vector Splitting (KFVS) scheme have the same physical mechanism and similar flux function, based on the analysis of the discretized KFVS scheme the weakness and advantage of the FVS scheme are closely observed. The subtle dissipative mechanism of the Godunov method in the 2D case is also analyzed, and the physical reason for shock instability, i.e., carbuncle phenomena and odd-even decoupling, is presented.

  12. A Note on the Convergence of the Godunov Method for Impact Problems

    CERN Document Server

    Banks, J W

    2012-01-01

    This paper identifies a new pathology that can be found for numerical simulations of nonlinear conservation law systems. Many of the difficulties already identified in the literature (rarefaction shocks, carbuncle phenomena, slowly moving shocks, wall heating, etc) can be traced to insufficient numerical dissipation, and the current case is no different. However, the details of the case we study here are somewhat unique in that the solution which is found by the numerics is very weak and can fail to have a derivative anywhere in the post-shock region.

  13. 1,001 words and phrases you never knew you didn't know hopperdozer, hoecake, ear trumpet, dort, and other nearly forgotten terms and expressions

    CERN Document Server

    Runyan, W R

    2010-01-01

    As times change so do the things we use and what we call them. W.R. Runyan has compiled a fascinating collection of words and phrases that, once common everywhere in America, are little known today. This book is a celebration of our linguistic past that will be a treat from word lovers everywhere. Do you know any of these: Snaffle, Steelie, Gully Washer, Cabriolet, Calk, Hardpan, Carbuncle, Pie Bird, Fid, or Hame? Did you know that a "Horse Apple" is actually an orange? Or that "Rolley Holley" is a marble game? With over one hundred illustrations, this is a book that will take you on

  14. Dermatological disorders in Tuvalu between 2009 and 2012.

    Science.gov (United States)

    Lan, Li-Jung; Lien, Ying-Shuang; Wang, Shao-Chuan; Ituaso-Conway, Nese; Tsai, Ming-Che; Tseng, Pao-Ying; Yeh, Yu-Lin; Chen, Chun-Tzu; Lue, Ko-Huang; Chung, Jing-Gung; Hsiao, Yu-Ping

    2015-09-01

    There is a distinct lack of knowledge on the prevalence of skin disorders in Tuvalu. The aim of the current study was to assess the prevalence of cutaneous diseases and to evaluate access dermatological care in Tuvalu. Cutaneous disorders in the people of Tuvalu between 2009 and 2012 were examined. The most common skin conditions were eczema/dermatitis, superficial fungal infections, impetigo, carbuncles, furuncles, folliculitis, acne, scabies, warts and keloids. Infrequent skin conditions included infectious granulomatous disease, albinism, actinic keratosis, skin cancer, cutaneous lupus erythematosus and mammary Paget's disease, which required medical attention. This is the first epidemiological report on skin disorders in the southwest Pacific Island, Tuvalu. PMID:25998560

  15. PHYTOCHEMICAL AND PHARMACOGNOSTICAL STUDIES OF MARTYNIA ANNUA PLANT

    Directory of Open Access Journals (Sweden)

    Katare Vivekanand

    2012-06-01

    Full Text Available Martynia annua (Martyniaceae is commonly known as “bichu”. In Ayurveda the leaves of the plant is useful in treatment of gargle, treat epilepsy, tuberculous, sore throat and also given local sedative effect. The whole plant is also used by Santal tribals (India for fever, hair loss, scabies, sores and carbuncles on the back In order to ensure the use of genuine and authentic material in the preparation of herbal formulations, pharmacognostical and phytochemical methods of standardization of the plant has been carried out in the present work. Macroscopic, microscopic and physico-chemical characters of the Martynia annuahas plant been carried out. Preliminary phytochemical analysis studies have been performed on the various extracts of Martynia annua plant. All these pharmacognostical and phytochemical studies can be used as a diagnostic tool for the correct identification of the plant and also to test adulteration if any.

  16. Two-dimensional adaptive mesh generation algorithm and its application with higher-order compressible flow solver

    International Nuclear Information System (INIS)

    A combined procedure for two-dimensional Delaunay mesh generation algorithm and an adaptive remeshing technique with higher-order compressible flow solver is presented. A pseudo-code procedure is described for the adaptive remeshing technique. The flux-difference splitting scheme with a modified multidimensional dissipation for high-speed compressible flow analysis on unstructured meshes is proposed. The scheme eliminates nonphysical flow solutions such as the spurious bump of the carbuncle phenomenon observed from the bow shock of the flow over a blunt body and the oscillation in the odd-even grid perturbation in a straight duct for the Quirk's odd-even decoupling test. The proposed scheme is further extended to achieve higher-order spatial and temporal solution accuracy. The performance of the combined procedure is evaluated on unstructured triangular meshes by solving several steady-state and transient high-speed compressible flow problems

  17. SKIN CARE IN AYURVEDA: A LITERARY REVIEW

    Directory of Open Access Journals (Sweden)

    Kumar Sarvesh

    2013-03-01

    Full Text Available Ayurvedic cosmeceuticals dates back to the Indus valley civilization and is being used in human society from ancient time. It is now gaining importance in the beautification and to cure the skin ailments. In last 3-4 decades the use of cosmetics has increased exponentially not only among female but also in male population and play an important role in the FMCG sector. In the ancient classical texts of Ayurveda there are several references of numerous medicinal plants and mode of applications of their processed formulation for enhancing complexion, treating acne, treating dark patches, curing boils and carbuncles, etc. Consideration in this field can be helpful in making the herbs more acceptable, precious, life saving and economy promoter for the mankind. This review made a humble effort to make a monograph of ayurvedic plants that were mentioned by ayurvedic luminaries in the field of skincare.

  18. Anti-inflammatory effects, nuclear magnetic resonance identification, and high-performance liquid chromatography isolation of the total flavonoids from Artemisia frigida

    Directory of Open Access Journals (Sweden)

    Qinghu Wang

    2016-04-01

    Full Text Available The aerial parts of Artemisia frigida Willd. are used to treat joint swelling, renal heat, abnormal menstruation, and sore carbuncle. The anti-inflammatory effects of A. frigida have been well-known in folk medicine, suggesting that components extracted from A. frigida could potentially treat inflammatory disease. With the aim of discovering bioactive compounds, in this study, we extracted total flavonoids from the aerial parts of A. frigida and investigated their anti-inflammatory effects against inflammation induced by carrageenan and egg albumin in rats. At the doses studied, total flavonoids (100 mg/kg, 200 mg/kg, and 400 mg/kg and some isolated compounds (30 mg/kg showed significant and dose-dependent anti-inflammatory effects. According to the high-performance liquid chromatography analysis of the total flavonoids from A. frigida, there are five major compounds, namely, 5-hydroxy-3′,4′-dimethoxy-7-O-β-d-glucuronide (F1, 5-hydroxy-3′,4′,5′-trimethoxy-7-O-β-d-glucuronide (F2, 5,7,3′-trihydroxy-6,4′-dimethoxyflavone (F3, 5,3′-dihydroxy-6,7,4′-trimethoxyflavone (F4, and 5,3′-dihydroxy-3,6,7,4′-tetramethoxyflavone (F5, which may explain the anti-inflammatory activity.

  19. A Time-Accurate Upwind Unstructured Finite Volume Method for Compressible Flow with Cure of Pathological Behaviors

    Science.gov (United States)

    Loh, Ching Y.; Jorgenson, Philip C. E.

    2007-01-01

    A time-accurate, upwind, finite volume method for computing compressible flows on unstructured grids is presented. The method is second order accurate in space and time and yields high resolution in the presence of discontinuities. For efficiency, the Roe approximate Riemann solver with an entropy correction is employed. In the basic Euler/Navier-Stokes scheme, many concepts of high order upwind schemes are adopted: the surface flux integrals are carefully treated, a Cauchy-Kowalewski time-stepping scheme is used in the time-marching stage, and a multidimensional limiter is applied in the reconstruction stage. However even with these up-to-date improvements, the basic upwind scheme is still plagued by the so-called "pathological behaviors," e.g., the carbuncle phenomenon, the expansion shock, etc. A solution to these limitations is presented which uses a very simple dissipation model while still preserving second order accuracy. This scheme is referred to as the enhanced time-accurate upwind (ETAU) scheme in this paper. The unstructured grid capability renders flexibility for use in complex geometry; and the present ETAU Euler/Navier-Stokes scheme is capable of handling a broad spectrum of flow regimes from high supersonic to subsonic at very low Mach number, appropriate for both CFD (computational fluid dynamics) and CAA (computational aeroacoustics). Numerous examples are included to demonstrate the robustness of the methods.

  20. Adjuvant effect of an extract from Cochinchina momordica seeds on the immune responses to ovalbumin in mice

    Institute of Scientific and Technical Information of China (English)

    XIAO Chenwen; HU Songhua; Rajput Zahid Iqbal

    2007-01-01

    The seed of the Momordica cochinchinensis (Lour.)Spreng as a traditional Chinese medicine has been utilized in China for more than 1 200 years.It is traditionally used for the treatment of inflammatory swelling,scrofula,tinea,diarrhea as well as suppurative skin infections such as sore,carbuncles,furuncles and boils in both humans and animals.In this study,an extract from Cochinchina momordica seeds(ECMS)is evaluated for its adjuvant effect and safety.The results suggest that when co-administered with ECMS in Balb/c mice,ovalbumin(OVA,10μg)may induce significantly higher specific antibody production than OVA used alone(P<0.05).Analysis of antibody isotypes indicates that the ECMS can promote the production of both IgG1 and IgG2a,concanavalin A,lipopolysaccharides or OVA are significantly higher in mice immunized with OVA mixed with ECMS than immunized with OVA alone or mixed with aluminum hydroxide(P<0.05).No local reactions and negative effects on the body weight gain occurred after the injection of OVA mixed with various amounts of ECMS in mice.Therefore,the ECMS is safe for injection and can be used as a potential vaccine adjuvant biasing the production of IgG2a in mice.

  1. An Overview to the Research on Clinical Application of Du Meridian%督脉的临床应用研究概况

    Institute of Scientific and Technical Information of China (English)

    张海山; 高希言

    2008-01-01

    Du meridian is one of the eight extra meridians, having the functions of defending pathogenic factors,inducing diaphoresis to dispel cold, warming the viscera and bowels, elevating the pure yang, promoting the flow qi by warming channels, promoting blood circulation to stop pain, clearing heat by dredging du meridian, treating carbuncle and malaria, dredging du meridian to treat encephalic disease, nourishing brain and nourish marrow, benefiting intelligence and spirit, waking up patient from unconsciousness, relieving convulsion, calming the nerves, stopping endogenous wind, calming the spirit. Moreover it also has the functions of sectional treatment and antidotal health care. Du meridian is widely used clinically in treating many kinds of diseases.%督脉为奇经八脉之一,在临床上具有温阳泻热的作用,可以卫外御邪、祛寒解表、温煦脏腑、升举清阳、温经通络、活血止痛、通督泻热、疗疔截疟.还有通督治脑的作用,可用于补脑益髓、聪神益智、醒神通脑、开窍启闭、镇惊安神、熄风定志.另外还具有分段主治的特性和强壮抗衰老的保健作用,临床应用十分广泛.

  2. The performance of flux-split algorithms in high-speed viscous flows

    Science.gov (United States)

    Gaitonde, Datta; Shang, J. S.

    1992-01-01

    The algorithms are investigated in terms of their behavior in 2D perfect gas laminar viscous flows with attention given to the van Leer, Modified Steger-Warming (MSW), and Roe methods. The techniques are studied in the context of examples including a blunt flow at Mach 16, a Mach-14 flow past a 24-deg compression corner, and a Mach-8 type-IV shock-shock interaction. Existing experimental values are compared to the results of the corresponding grid-resolution studies. The algorithms indicate similar surface pressures for the blunt-body and corner flows, but the van Leer approach predicts a very high heat-transfer value. Anomalous carbuncle solutions appear in the blunt-body solutions for the MSW and Roe techniques. Accurate predictions of the separated flow regions are found with the MSW method, the Roe scheme, and the finer grids of the van Leer algorithm, but only the MSW scheme predicts an oscillatory supersonic jet structure in the limit cycle.

  3. Anti-bacterial and anti-inflammatory effects of ethanol extract from Houttuynia cordata poultice.

    Science.gov (United States)

    Sekita, Yasuko; Murakami, Keiji; Yumoto, Hiromichi; Mizuguchi, Hiroyuki; Amoh, Takashi; Ogino, Satoshi; Matsuo, Takashi; Miyake, Yoichiro; Fukui, Hiroyuki; Kashiwada, Yoshiki

    2016-06-01

    Houttuynia cordata (HC) has been commonly used as many traditional remedies in local areas of Japan. Although many pharmacological activities of HC have been reported, the mechanism underlying the effect of HC remains unknown. We conducted the interview survey in Japan to verify how HC was actually used. The interview survey revealed that HC poultice (HCP) prepared from smothering fresh leaves of HC was most frequently used for the treatment of purulent skin diseases including furuncle and carbuncle with high effectiveness. Ethanol extract of HCP (eHCP) showed anti-bacterial effects against methicillin-resistant Staphylococcus aureus (MRSA), and showed an anti-biofilm activity against MRSA. eHCP showed dose-dependent inhibition of S. aureus lipoteichoic acid (LTA)-induced interleukin-8 and CCL20 production in human keratinocyte without any cytotoxicity. These results suggest that HCP is effective for skin abscess and its underlying mechanism might be the complicated multiple activities for both bacteria and host cells. PMID:27023331

  4. Evidence for increasing severity of community-onset boils and abscesses in UK General Practice.

    Science.gov (United States)

    Shallcross, L J; Hayward, A C; Johnson, A M; Petersen, I

    2015-08-01

    In England, hospital admissions for severe staphylococcal boils and abscesses trebled between 1989 and 2004. We investigated this trend using routine data from primary and secondary care. We used The Health Improvement Network (THIN), a large primary-care database and national data on hospital admissions from Hospital Episode Statistics (HES). Time trends in the incidence of primary-care consultations for boils and abscesses were estimated for 1995-2010. HES data were used to calculate age-standardized hospital admission rates for boils, abscesses and cellulitis. The incidence of boil or abscess was 450 [95% confidence interval (CI) 447-452] per 100 000 person-years and increased slightly over the study period (incidence rate ratio 1·005, 95% CI 1·004-1·007). The rate of repeat consultation for a boil or abscess increased from 66 (95% CI 59-73) per 100 000 person-years in 1995 to peak at 97 (95% CI 94-101) per 100 000 person-years in 2006, remaining stable thereafter. Hospital admissions for abscesses, carbuncles, furuncles and cellulitis almost doubled, from 123 admissions per 100 000 in 1998/1999 to 236 admissions per 100 000 in 2010/2011. Rising hospitalization and recurrence rates set against a background of stable community incidence suggests increased disease severity. Patients may be experiencing more severe and recurrent staphylococcal skin disease with limited treatment options. PMID:25530161

  5. Suppressive effects of an ethanol extract of Gleditsia sinensis thorns on human SNU-5 gastric cancer cells.

    Science.gov (United States)

    Lee, Se-Jung; Ryu, Dong Hee; Jang, Lee Chan; Cho, Seok-Cheol; Kim, Wun-Jae; Moon, Sung-Kwon

    2013-04-01

    The thorns of Gleditsia sinensis are a traditional Oriental medicine used for the treatment of swelling, suppuration, carbuncle and skin diseases. In the present study, we identified a novel molecular mechanism by which an ethanol extract of Gleditsia sinensis thorns (EEGS) inhibits the growth of the SNU-5 human gastric cancer cell line. EEGS treatment inhibited cell growth and was associated with G1 phase cell cycle arrest at a concentration of 400 µg/ml (IC50) in SNU-5 cells. Treatment with EEGS also stimulated p21WAF1 expression, which significantly decreased the expression of cyclins and cyclin-dependent kinases (CDKs). Further study suggested that p38 MAP kinase pathways may be involved in the inhibition of cell proliferation through p21WAF1‑dependent G1 phase cell cycle arrest in EEGS-treated cells. In addition, NF-κB and AP-1 transcription factor binding sites were identified as the cis-elements for tumor necrosis factor-α (TNF-α)-induced matrix metalloproteinase-9 (MMP-9) expression in SNU-5 cells, as determined by gel-shift assay. Treatment of cells with EEGS suppressed MMP-9 expression induced by TNF-α via a decrease in the binding activity of both NF-κB and AP-1 motifs. These data demonstrate that EEGS-mediated inhibition of cell growth appears to involve the activation of p38 MAP kinase, subsequently leading to the induction of p21WAF1 and the downregulation of cyclin D1/CDK4 and cyclin E/CDK2 complexes. Moreover, EEGS strongly inhibited TNF-α-induced MMP-9 expression by impeding the DNA binding activity of NF-κB and AP-1. Overall, these results provide a potential mechanism for EEGS in the treatment of gastric cancer. PMID:23381601

  6. Gleditsia sinensis Thorn Attenuates the Collagen-Based Migration of PC3 Prostate Cancer Cells through the Suppression of α2β1 Integrin Expression

    Directory of Open Access Journals (Sweden)

    Sujin Ryu

    2016-03-01

    Full Text Available Gleditsia sinensis thorns (GST have been used as a traditional medicine for carbuncles and skin diseases. The purpose of this study was to decide whether non-toxicological levels of water extract of GST (WEGST are effective in inhibiting the progress of prostate cancer formation and to identify the target molecule involved in the WEGST-mediated inhibitory process of prostate cancer cell migration and in vivo tumor formation. Through the Boyden chamber migration assay, we found that non-toxic levels of WEGST could not attenuate the PC3 migration to the bottom area coated with serum but significantly inhibited PC3 cell migration to the collagen-coated bottom area. We also found that non-toxic levels of WEGST significantly attenuated collagen against adhesion. Interestingly, ectopic administration of WEGST could not affect the expression of α2β1 integrin, which is known as a receptor of collagen. However, when the PC3 cells adhered to a collagen-coated plate, the expression of α2 integrin but not that of β1 integrin was significantly inhibited by the administration of non-toxic levels of WEGST, leading to the inhibition of focal adhesion kinase (FAK phosphorylation. Furthermore, oral administration of WEGST (25 mg/kg/day significantly inhibited the size of a PC3 cell-xenografted tumor. Taken together, these results suggest a novel molecular mechanism for WEGST to inhibit prostate cancer progression at particular stages, such as collagen-mediated adhesion and migration, and it might provide further development for the therapeutic use of WEGST in the treatment of prostate cancer progression.

  7. Public awareness of testicular cancer and testicular self-examination in academic environments: a lost opportunity

    Directory of Open Access Journals (Sweden)

    Henry A. A. Ugboma

    2011-01-01

    Full Text Available BACKGROUND: Although testicular cancer is the most common cancer among 18- to 50-year-old males, healthcare providers seldom teach testicular self-examination techniques to clients, thus potentially missing opportunities for early detection. This form of cancer is easily diagnosable by testicular self-examination and is 96% curable if detected early. Periodic self-examination must be performed for early detection. Knowledge deficits and sociocultural norms contribute to low levels of health-related knowledge in most patients, resulting in undue delays before seeking medical advice. OBJECTIVE: Our aim is to assess the level of awareness of testicular cancer and the prevalence of the practice of testicular self-examination in academic environments to enable appropriate interventions. METHOD: A cross-sectional survey was administered to 750 consecutive males aged 18-50 years in three tertiary institutions in Port Harcourt from October 2008 to April 2009. RESULT: Knowledge or awareness of testicular cancer was poor. Almost all of the respondents were unaware that testicular lumps may be signs of cancer. A lump was typically construed as a benign carbuncle or something that could resolve spontaneously. The main factor contributing to respondents' lack of knowledge of testicular cancer was that few reported that they were "ever taught about testicular self-examination." CONCLUSION: Young adult men are unaware of their risk for testicular cancer, which is the most common neoplasm in this age group. Healthcare providers are not informing them of this risk, nor are they teaching them the simple early detection technique of self-examination of the testes.

  8. Modern Research and Relationship of Cool Traditional Chinese Medicine Properties%药性凉的现代研究及相互关系

    Institute of Scientific and Technical Information of China (English)

    魏珍珍; 苗艳艳; 苗明三

    2013-01-01

    ,flavored medicine,channel tropism,chemical composition.Methods:Use the " features-pharmacology-clinical of traditional Chinese medicine database systems ",inquiry associated frequency between "cool" and functions,pharmacology,traditional Chinese medical indications,modern medical indications,flavored medicine,channel tropism,chemical composition,according to the frequency,take cover 2/3 of most high frequency for basic area,take cover 2/3 of remaining most high frequency for joint area,remaining for extended area.Results:Basic functions of cool traditional Chinese medicine are Clear heat,detoxification,detumescence and hemostatic; basic pharmacological actions are Anti-inflammatory,antibacterial,antitumor,calm,influence the cardiovascular system,reducing blood fat,protect liver,hemostatic,antisterility; Cool medicine of traditional Chinese medicine basic indications for carbuncle swollen,pharyngitis,edema,quench hematochezia,urination,thirsty,vomiting blood,hematuria,high blood pressure,heat flow field,hot shower,hot and humid jaundice,fever god faint,have a headache,measles opaque,pathogenic fever have a headache,sputum nuclear nosebleed,excessive bleeding injury,chronic hepatitis,scrofula,canker,surprised ulcerated tic,acute hepatitis,jaundice,hypertension neck strong pain,carbuncles and ulcers,under the uterine blood,conjunctival congestion,inflammation of the severe pain,dizziness,diarrhoea,stroke sputum fan,carbuncle swollen chuangdu; Cool medicine of modern medical basic indications for dysentery,hypertension disease,angina,coronary heart disease,migraine,pertussis,hyperlipidemia,hepatitis,dizziness,epilepsy,liver cirrhosis,acute conjunctivitis,headache,diphtheria,leucopenia,flat wart,acute or chronic hepatitis,pulmonary tuberculosis And cool often combined the basic taste for sweet,bitter,essien;Cool medicine to the basic for liver,lung,stomach,heart,Cool medicine basic chemical components is organic acids,glycosides,tannins,saccharides,flavonoids,inorganic matter

  9. Antiproliferative and anti-inflammatory polyhydroxylated spirostanol saponins from Tupistra chinensis.

    Science.gov (United States)

    Xiang, Limin; Yi, Xiaomin; Wang, Yihai; He, Xiangjiu

    2016-01-01

    Tupistra chinensis is widely distributed in southwestern China and its rhizome is a famous folk medicine for the treatment of carbuncles and pharyngitis. Its chemical identity of potent antiproliferative and anti-inflammatory constituents has been carried out in this study. Twenty-three polyhydroxylated spirostanol saponins, including nine novels, were isolated and identified. The new spirostanol saponins were elucidated as spirost-25(27)-en-1β,2β,3β,4β,5β-pentol-2-O-β-D-xylopyranoside (1), spirost-25(27)- en-1β,2β,3β,4β,5β-pentol-2-O-α-L-arabinopyranoside (2), spirost-25(27)-en- 1β,3α,5β-triol (12), spirost-25(27)-en-1β,3α,4β,5β,6β-pentol (13), spirost-25(27)-en- 1β,2β,3β,5β-tetraol-5-O-β-D-glucopyranoside (16), 5β-spirost-25(27)-en-1β,3β-diol- 3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside (17), (25R)-5β-spirostan- 1β,3β-diol-3-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranoside (18), (25R)-5β- spirostan-1β,3β-diol-3-O-β-D-fructofuranosyl-(2 → 6)-β-D-glucopyranoside (19), 5β-spirost-25(27)-en-3β-ol-3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside (20). The antiproliferative effects against seven human cancer cell lines and inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in a macrophage cell line RAW 264.7 were assayed for all the isolated compounds. Compounds 17, 19 and 21 exhibited potential antiproliferative activities against all of human cancer cell lines tested. Compounds 21 showed significant inhibition on NO production with IC50 values of 11.5 μM. These results showed that the spirostanol saponins isolated from the dried rhizomes of T. chinensis have potent antiproliferative and anti-inflammatory activities and T. chinensis might be used as anticancer and.anti-inflammatory supplement. PMID:27530890

  10. An atlas of the morphological manifestations of hidradenitis suppurativa.

    Science.gov (United States)

    Scheinfeld, Noah

    2014-01-01

    This article is dermatological atlas of the morphologic presentations of Hidradenitis Suppurativa (HS). It includes: superficial abscesses (boils, furnucles, carbuncles), abscesses that are subcutaneous and suprafascial, pyogenic granulomas, cysts, painful erythematous papules and plaques, folliculitis, open ulcerations, chronic sinuses, fistulas, sinus tracts, scrotal and genital lyphedema, dermal contractures, keloids (some that are still pitted with follicular ostia), scarring, skin tags, fibrosis, anal fissures, fistulas (i.e. circinate, linear, arcuate), scarring folliculitis of the buttocks (from mild to cigarette-like scarring), condyloma like lesions in intertrigous areas, fishmouth scars, acne inversa, honey-comb scarring, cribiform scarring, tombstone comedones, and morphia-like plaques. HS can co-exist with other follicular diseases such as pilonidal cysts, dissecting cellulitis, acne conglobata, pyoderma gangrenosum, and acanthosis nigricans. In sum, the variety of presentations of HS as shown by these images supports the supposition that HS is a reaction pattern.HS is a follicular based diseased and its manifestations involve a multitude of follicular pathologies [1,2]. It is also known as acne inversa (AI) because of one manifestation that involves the formation of open comedones on areas besides the face. It is as yet unclear why HS is so protean in its manifestations. HS severity is assessed using the Hurley Staging System (Table 1). It also remains unclear why hidradentitis may remain limited to Hurley Stage 1, evolve to the more confluent (Hurley Stage 2), or progress even further to the fully confluent (Hurley Stage 3).In addition, HS can be associated with other follicular based diseases such as pilonidal cysts (PCs) of the sacrum and buttocks, dissecting cellulitis (DC), and acne conglobata (AC), which usually involves the face, chest, When HS occurs with PCs, DC, and/or AC it is referred to as the follicular occlusion triad or tetrad [2]. HS

  11. Apoptotic effects of extract from Cnidium monnieri (L.) Cusson by adenosine monosphosphate-activated protein kinase-independent pathway in HCT116 colon cancer cells.

    Science.gov (United States)

    Lim, Eun Gyeong; Kim, Guen Tae; Lee, Se Hee; Kim, Sang-Yong; Kim, Young Min

    2016-06-01

    Colon cancer, a common malignancy, can occur due to poor eating habits and increasing age. Consequently, careful regulation of eating habits may serve as a possible method for preventing the occurrence or progression of colon cancer. Extracts of the fruit of Cnidium monnieri (L.) Cusson are well‑known as an effective herbal medicine for the treatment of pain in female genitalia and carbuncle. However, there have been no studies on the apoptotic effects of Cnidium monnieri (L.) Cusson (CME). Adenosine monophosphate‑activated protein kinase (AMPK), the major regulator of energy metabolism, is activated by metabolic stress, including hypoxia and glucose deprivation. Activation of AMPK inhibits cell proliferation and induces apoptosis through the inhibition of phosphorylated (p)‑Akt and control of B‑cell lymphoma 2 (Bcl‑2) family members. The pro‑apoptotic proteins Bcl‑2‑associated X protein (Bax) and Bcl‑2‑homologous antagonist killer (Bak), are activated by their translocation to mitochondria from the cytosol. Translocation of Bax/Bak induces outer membrane permeabilization and is likely to lead to apoptosis through cytochrome C release and caspase activity. In the present study, the apoptotic effects and influence on mitochondria‑mediated apoptotic proteins of CME in HCT116 cells were assessed. We hypothesized that CME may have an effect on the inhibition of p‑Akt in an AMPK‑independent pathway. The present study demonstrated that CME induced the release of LDH and apoptosis through its inhibition of p‑Akt to control Bcl‑2 and activate Bax and Bak. Co‑treatment with CME and AMPK inhibitors showed that CME‑induced apoptosis does not occurr through a AMPK‑dependent pathway. Therefore, the present study determined, for the first time, that CME induced apoptosis as a result of causing metabolic stresses due to directly regulation of the de‑phosphorylation of Akt, whereas it did not control the AMPK-dependent pathway in HCT116

  12. Comparison of the generalized Riemann solver and the gas-kinetic scheme for inviscid compressible flow simulations

    International Nuclear Information System (INIS)

    The generalized Riemann problem (GRP) scheme for the Euler equations and gas-kinetic scheme (GKS) for the Boltzmann equation are two high resolution shock capturing schemes for fluid simulations. The difference is that one is based on the characteristics of the inviscid Euler equations and their wave interactions, and the other is based on the particle transport and collisions. The similarity between them is that both methods can use identical MUSCL-type initial reconstructions around a cell interface, and the spatial slopes on both sides of a cell interface involve in the gas evolution process and the construction of a time-dependent flux function. Although both methods have been applied successfully to the inviscid compressible flow computations, their performances have never been compared. Since both methods use the same initial reconstruction, any difference is solely coming from different underlying mechanism in their flux evaluation. Therefore, such a comparison is important to help us to understand the correspondence between physical modeling and numerical performances. Since GRP is so faithfully solving the inviscid Euler equations, the comparison can be also used to show the validity of solving the Euler equations itself. The numerical comparison shows that the GRP exhibits a slightly better computational efficiency, and has comparable accuracy with GKS for the Euler solutions in 1D case, but the GKS is more robust than GRP. For the 2D high Mach number flow simulations, the GKS is absent from the shock instability and converges to the steady state solutions faster than the GRP. The GRP has carbuncle phenomena, likes a cloud hanging over exact Riemann solvers. The GRP and GKS use different physical processes to describe the flow motion starting from a discontinuity. One is based on the assumption of equilibrium state with infinite number of particle collisions, and the other starts from the non-equilibrium free transport process to evolve into an

  13. Bacterial diseases of the skin.

    Science.gov (United States)

    Edlich, Richard F; Winters, Kathryne L; Britt, L D; Long, William B

    2005-01-01

    be divided into either a deep or a superficial type. In the superficial type, the pustule is located at the opening of the hair follicle. In the deep form, the infection may extend beyond the confines of the hair follicle, becoming a furuncle or boil. Carbuncles are aggregates of interconnected furuncles that drain through multiple openings of the skin. Treatment of folliculitis must include searching for and avoiding any factors predisposing to infection. If topical antibiotic therapy is ineffective in controlling the infection, surgical drainage of the infected skin abscess will be necessary. Paronychia is the most common bacterial infection of the hand, which often requires surgical incisional drainage. Similarly, a felon that is an infection of the distal pulp of a finger usually requires surgical drainage. Finally, cellulitis is an acute inflammatory reaction involving the skin and underlying subcutaneous tissue. It usually starts as erysipelas and may advance to lymphangitis, lymphadenitis, or gangrene,which will respond to life-saving interventions in the hospital that usually include systemic antibiotic treatment as well as surgical intervention. PMID:16218899

  14. - Bacillus anthracis, utilización de un Sistema de Información Geográfico (SIG, para el análisis espacio temporal de 54 brotes de carbunclo rural en el partido de Azul, Bs. As., Argentina (Bacillus anthracis, use of a Geographical infoormation Service (GIS, for the temporary space analysis of 54 outbreaks of rural anthax in the county of Azul, Province of Buenos Aires, Argentina

    Directory of Open Access Journals (Sweden)

    Vazquez P.

    2006-02-01

    Full Text Available Resumen. El objeto de este trabajo es utilizar un Sistema de Información Geográfico (SIG para el análisis epidemiológico del Carbunclo Rural aplicado a un ecosistema ganadero, integrado por 618.000 bovinos, distribuidos en 1.350 establecimientos del partido de Azul, Provincia de Buenos Aires, Argentina. Esto permitió estudiar hechos epidemiológicos de una enfermedad de antigua data como es el Carbunclo Rural. Su agente causal el Bacillus anthracis, posee la característica de formar esporos que permite mantenerse durante decenas de años en el ambiente com capacidad de transmitir la enfermedad a otrois animales susceptibles. Se describe la metodología para su diagnóstico y los distintos elementos que integran el Sistema de Información Geográfico. Los 54 brotes identificados entre los años 1989 / 2005 fueron georreferenciados para posteriormente relacionarlos con las vías de avenamiento de aguas del partido de Azul, lãs características de sus suelos y la ubicación de las poblaciones de las poblaciones rurales que comparten la zona de isorriesgo. Se plantea un sistema de alerta epidemiológico temprano para establecimientos ganaderos que comparten vías de avenamiento de agua en común con el brote de Carbunclo diagnosticado. El 93 % de los brotes ocurrieron en establecimientos que comparten vías de avenamiento, mientras que el 7 % restante en establecimientos ganaderos ubicados fuera del área de influencia de estas vías Summary. The objjective of this study was the use of a Geographical Information Service (GIS for the epidemiologiacal analysis of rural Anthrax applied to a catle ecosystem, which includes 618.000 cattle, distributed on 1.350 farms in the county of Azul, Province of Buenos Aires, Argentina. This allowed studying long past epidemiological occurrences of a disease such as rural carbuncle Its causing egent is Bacillus anthracis, which has the property of forming spores That permit being maintained dozens of years in

  15. 朱丹溪脾胃观源流与特征初探%A Preliminary Study on the Origins and Characteristics of Zhu Danxi's Concept of Spleen-Stomach

    Institute of Scientific and Technical Information of China (English)

    沈堂彪

    2016-01-01

    Objective] The article analyzed the origins of Zhu Danxi's concept of the spleen-stomach and the characteristics of the prescription, and explored the content of the academic research of Zhu Danxi. [Methods] Through literature method, the control analysis of the formation of succession context of Zhu Danxi's concept of the spleen-stomach, from three aspects, it analyzes the main characteristics of the view of the spleen and stomach on the physiology and pathology of spleen-stomach, spleen and stomach disease treatment, and treatment through the spleen-stomach.[Results] Zhu Danxi's concept of the spleen-stomach had the close relation with apprentice teacher and famous experts. The basic viewpoints origin from Liu Wansu, draws expelling spleen and stomach drug laws of Li Dongyuan, critically to retain the Zhang Congzheng's spleen-stomach academics, fully inherit the clinical experience of Luo Zhiti, and then form the concept of the spleen-stomach on physiological and the characteristics including the emphasis on physiological and pathological of the spleen-stomach and the prescription by protecting spleen-stomach. The treatment methods through the spleen-stomach to treat the exogenous and miscellaneous disease, including the tonifying spleen and regulating qi to dispel six stagnation, tonifying spleen and strengthening qi to remove exogenous, tonifying spleen and nourishing blood to resolute carbuncle and abscess, tonifying spleen and sweat to eliminate malaria cough, applicable law of clearing stomach and intestinal. [Conclusion] The formation and characteristics of Zhu Danxi's concept of the spleen-stomach is of great practical significance for guiding the clinical application and the cultivation of traditional Chinese medicine.%[目的]探讨朱丹溪脾胃观形成源流及其理法方药规律与特点,拓展丹溪学术研究内容。[方法]以文献学的方法,对照分析朱丹溪脾胃观形成的师承脉络,从脾胃的生理

  16. 朱槿花苞提取物治疗皮肤疖痈溃疡及其机制研究%Research in skin healing and repair function and mechanism of Hibiscus rosa-sinensis Linn bud extract

    Institute of Scientific and Technical Information of China (English)

    姜霁洋; 徐涵; 白雪婷; 程訸; 林艳玲; 凌震; 陈一村; 石刚刚

    2015-01-01

    Aim To test the skin healing and repairing efficacy and the mechanism of Hibiscus rosa-sinensis L bud extract by using the animal models. Methods KM mice were randomly divided into three groups:the model group, the positive control group, and the n-bu-tyl alcohol extract ( HrBN) group. Using the boils and carbuncles model, the healing condition of all the animals were observed. KM mice were kept in the SPF condition room and divided into five groups: the model group, the positive control group, and the low, middle, high dose groups. Using the full-thickness loss model, the repairing results of all the mice were ob-served. Through the antimicrobial test, the results of MIC and inhibition zone were obtained. The carbon clearance test was used to collect the blood at the time 5min and 15min, and get the liver and spleen, and the results of K andαwere obtained. Results In vivo ex-periments showed there was significant difference be-tween groups;the HrBN extract had the outstanding ef-ficacy in healing and repairing skin boils and full-thickness loss models. It had higher recovery rate than other ethanol extract, such as ethyl acetate extract and chloroform extract. In vitro experiments showed that the HrBN extract, ethyl acetate extract ( HrBE) ,AB-8 macroporous resin 30% alcohol part and 60% alcohol part had obvious antimicrobial efficacy. The carbon clearance test showed HrBN had a good effect in im-proving immune function, and it can increase the K and α. Conclusion HrBN in animal models exerts good skin healing and repairing efficacy, which might be related to its antibacterial activity and immunologic enhancement function.%目的:研究朱槿花苞提取物对小鼠皮肤疖痈溃疡模型的治疗作用,并对其可能作用机制进行探讨。方法将昆明小鼠分为模型组、阳性药组和朱槿花苞正丁醇萃取物( HrBN)组,采用小鼠疖痈模型,观察给药后实验结果。将昆明小鼠分为模型组、阳性药组和HrBN低、

  17. 清热药的特点及现代研究%Modern Research and Relationship of Heat-clearing Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    李瑞奇; 白明; 苗明三

    2013-01-01

    Objective:To explore relationship between heat-c1earing traditional Chinese medicine and pharmacological action,traditional Chinese medical indications,modern medical indications,medicine properties,flavour of a medicine,channel tropism,chemical composition.Methods:Use the " properties and flavour of traditional Chinese medicine database systems ",inquiry associated frequency between function " Heat-clearing" and pharmacological action,traditional Chinese medical indications,modern medical indications,medicine properties,flavour of a medicine,channel tropism,chemical composition,according to the frequency,take cover 2/3 of most high frequency for basic area,take cover 2/3 of remaining most high frequency for joint area,remaining for extended area.Results:Basic pharmacological action of heat-clearing traditional Chinese medicine are antibacterial,anti-inflammatory,antitumor,antipyretic,calm,affecting the cardiovascular system,diuresis; TCM basic indications are carbuncle swollen,jaundice,sore throat pain and swelling,boils,vomiting blood,eyes red swelling and pain,heat astringent pain,nose bleeding,edema,inflammation of the throat,erysipelas,headache,snake bite,wind heat cold ; modern medicine basic indications are eczema,bacillary dysentery,hypertension,chronic bronchitis,colds,burns,whooping cough,stomach ulcers,hepatitis,mumps,pneumonia,herpes zoster,edema,pain and swelling of the throat,duodenal ulcer,suppurative otitis media,dermatitis,headache,coronary heart disease,bronchitis,verruca,acute tonsillitis,diarrhea,hyperlipidemia,cough,jaundice;basic medicine properties of heat-cleating TCM are cold,micro-cold;basic flavour of a medicine combined with heatclearing traditional Chinese medicine are bitter,sweet; basic channel tropisms are liver,lung,stomach,large intestine,heart;the basic chemical compositions of heat-cleating traditional Chinese medicine are organic acid,flavonoids,glycosides,alkaloids,sugars,tannins,amino acids,esters,volatile oil