WorldWideScience

Sample records for candesartan medica study

  1. Hydrochlorothiazide, but not Candesartan, aggravates insulin resistance and causes visceral and hepatic fat accumulation: the mechanisms for the diabetes preventing effect of Candesartan (MEDICA) Study

    DEFF Research Database (Denmark)

    Eriksson, J.W.; Jansson, P.A.; Carlberg, B.;

    2008-01-01

    after treatment with candesartan, hydrochlorothiazide, and placebo. Twenty-six nondiabetic, abdominally obese, hypertensive patients were included in a multicenter 3-way crossover trial, and 22 completers (by predefined criteria; 10 men and 12 women) were included in the analyses. They underwent 12-week...

  2. Candesartan

    Science.gov (United States)

    ... It works by blocking the action of certain natural substances that tighten the blood vessels, allowing the ... Candesartan controls high blood pressure but does not cure it. Your blood pressure may decrease during the ...

  3. Comparative effect of olmesartan and candesartan on lipid metabolism and renal function in patients with hypertension: a retrospective observational study

    Directory of Open Access Journals (Sweden)

    Nakayama Tomohiro

    2011-08-01

    Full Text Available Abstract Background Angiotensin II receptor blockers (ARBs, including olmesartan and candesartan, are widely used antihypertensive agents. Many clinical studies have demonstrated that ARBs have organ-protecting effects, e.g., cardioprotection, vasculoprotection and renoprotection. However, the effect of prolonged olmesartan monotherapy on lipid metabolism in patients with hypertension is less well studied. We performed a retrospective observational study to compare the effects of olmesartan with those of candesartan, focusing on lipid metabolism and renal function. Methods We used data from the Clinical Data Warehouse of Nihon University School of Medicine obtained between Nov 1, 2004 and Feb 28, 2011, to identify cohorts of new olmesartan users (n = 168 and candesartan users (n = 266. We used propensity-score weighting to adjust for differences in all covariates (age, sex, comorbid diseases, previous drugs between olmesartan and candesartan users, and compared serum chemical data including serum triglyceride (TG, LDL-cholesterol (LDL-C, total cholesterol (TC, potassium, creatinine and urea nitrogen. The mean exposure of olmesartan and candesartan users was 126.1 and 122.8 days, respectively. Results After adjustment, there were no statistically significant differences in all covariates between olmesartan and candesartan users. The mean age was 60.7 and 61.0 years, and 33.4% and 33.7% of olmesartan and candesartan users were women, respectively. There were no statistically significant differences in mean values for all laboratory tests between baseline and during the exposure period in both olmesartan and candesartan users. In olmesartan users, the reduction of serum TG level was significant in comparison with that in candesartan users. Other parameters of lipid profile and renal function showed no statistically significant difference in the change from baseline to during the exposure period between olmesartan and candesartan users. Conclusions

  4. Bioequivalence study of two formulations of candesartan cilexetil tablet in healthy subjects under fasting conditions

    Directory of Open Access Journals (Sweden)

    Tjandrawinata RR

    2013-08-01

    Full Text Available Raymond R Tjandrawinata,1 Effi Setiawati,2 Danang Agung Yunaidi,2 Ronal Simanjuntak,2 Iwan Dwi Santoso,2 Liana W Susanto1 1Dexa Laboratories of Biomolecular Sciences (DLBS, Cikarang, Indonesia; 2Bioavailability and Bioequivalence Laboratory, PT Equilab International, Jakarta, Indonesia Introduction: The present study was conducted to compare the bioavailability of two candesartan cilexetil 16 mg tablet formulations (test and reference formulations. Materials and methods: This study was a randomized, single- blind, two-period, cross-over study which included 24 healthy adult male and female subjects under fasting conditions. The pharmacokinetic parameters were determined based on the concentrations of candesartan (CAS 139481-59-7, using ultra-pressure high-performance liquid chromatography with a tandem mass spectrometer detector. In each of the two study periods (separated by a washout period of 1 week, a single dose of test or reference product was administered. The pharmacokinetic parameters assessed were area under the plasma concentration time curve (AUC from time 0 hours to 24 hours, AUC from time zero to infinity, the peak plasma concentration of the drug (Cmax, time to achieve the Cmax, and the elimination half-life. Results: The geometric mean ratios (90% confidence interval of the test drug/reference drug for candesartan were 100.92% (92.15%–110.52% for the AUC from 0 hours to 24 hours, 100.24% (92.24%–108.95% for the AUC from time zero to infinity, and 106.71% (93.20%–122.18% for the Cmax. The differences between the test and reference product in the time to achieve Cmax values and elimination half-life values were not statistically significant (P > 0.05. The 90% confidence intervals of the test/reference AUC ratio and Cmax ratio of candesartan were within the acceptance range for bioequivalence. There was no adverse event encountered during this bioequivalence study. Conclusion: It was concluded that the two candesartan tablet

  5. Solid Self-Microemulsifying Formulation for Candesartan Cilexetil

    OpenAIRE

    Nekkanti, Vijaykumar; Karatgi, Pradeep; Prabhu, Raghavendra; Pillai, Raviraj

    2009-01-01

    Sparingly, water-soluble drugs such as candesartan cilexetil offer challenges in developing a drug product with adequate bioavailability. The objective of the present study was to develop and characterize self-microemulsifying drug delivery system (SMEDDS) of candesartan cilexetil for filling into hard gelatin capsules. Solubility of candesartan cilexetil was evaluated in various nonaqueous careers that included oils, surfactants, and cosurfactants. Pseudoternary phase diagrams were construct...

  6. The effect of carvacrol on Enterococcus faecalis as an intracanal medicament-Invitro study

    Directory of Open Access Journals (Sweden)

    Sharifian M.

    2009-08-01

    Full Text Available "nBackground and Aim: Researches have shown that bacteria play the main role in development of pulpal and periapical diseases. Chemo-mechanical cleaning of infected root-canal system can not remove all of the microorganisms. Thus interappointment medicaments are necessary to aid this goal. Calcium hydroxide is one of the most useful medicaments in root canal therapy, but this medicament can not eliminated all of the bacteria in root canal system. Carvacrol is an edible plant extract that has antimicrobial and anti-inflammatory effects. If this extract is effective against endodontic bacteria, it can be used as an root canal medicament. "nMaterials and Methods: In this experimental study, Initially, MIC and MBC of carvacrol detected with Macro broth dilution method and determined as 0.3% and 0.6%, respectively. After that, 30 single root and single canal extracted human teeth were used in this study. The number of specimens determined in a pilot study on 4 extracted teeth. After preparation to apical size # 30 with hand and rotary instruments, teeth were randomly divided into two experimental and two control groups. After culturing Enterococcus faecalis in prepared canals, we used emulsion of 0.6% carvacrol and calcium hydroxide in two A and B experimental groups for 7 days as the intracanal medicament. Microbial samples obtained before and after experiment. Then, canals with negative culture selected to obtain dentinal shaving to culture. Data obtained from microbiological samples analyzed with kruskal-wallis and Bonferroni tests. "nResults: Results of this study showed that emulsion of 0.6% carvacrol has no significant difference with calcium hydroxide in elimination enterococcus faecalis after 7 days dressing (p>0.05. "nConclusion: Carvacrol can be used as an intrappointment intracanal medicament.

  7. Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials

    DEFF Research Database (Denmark)

    Chaturvedi, Nish; Porta, Massimo; Klein, Ronald;

    2008-01-01

    BACKGROUND: Results of previous studies suggest that renin-angiotensin system blockers might reduce the burden of diabetic retinopathy. We therefore designed the DIabetic REtinopathy Candesartan Trials (DIRECT) Programme to assess whether candesartan could reduce the incidence and progression of ...

  8. Studies on De Materia Medica of Dioscorides in the Islamic era

    Directory of Open Access Journals (Sweden)

    Vedat Yildirim, Rifat

    2013-06-01

    Full Text Available Pedanius Dioscorides was a Roman army surgeon in the first century A.D. His great work called De Materia Medica is widely accepted as the foremost pharmaceutical source of antiquity. Dioscorides was the originator of materia medica (pharmacology, and he took advantage of his extensive travels to study plants. Dioscorides was considered a major authority on simple drugs for sixteen centuries. De Materia Medica served as a corner stone for both western and eastern pharmaceutical and herbal writing, and was translated into Syriac, Arabic, and Persian, as well as Latin. The particular characteristic of medical therapy in the Medieval Period was the extensive employment of drugs of all kinds. For this reason, Dioscorides’ De Materia Medicawas not only studied closely, but it also became a text book that Turk-Islamic scientists frequently referred to in their writings.Pedanius Dioscórides fue médico cirujano en el ejército romano en el siglo I d.C. Su gran obra llamada De Materia Medica es conocida como la principal fuente de farmacopea de la antigüedad. Dioscórides fue el inventor de la materia medica, y aprovechó sus extensos viajes para dedicarse al estudio de las plantas. Dioscórides fue considerado una eminencia en el tema de las drogas de origen natural a lo largo de dieciséis siglos. De Materia Medica sirvió como piedra angular para los textos farmacéuticos y herbarios tanto en occidente como en oriente y fue traducida al siríaco, árabe y persa, además de al latín. La particular característica de la terapia médica en la época medieval fue el uso extensivo de todo tipo de drogas. Por esta razón, además de estudiarse minuciosamente, De Materia Medica de Dioscórides se convirtió también en un libro de texto al que frecuentemente hacían referencia los científicos turco-islámicos en sus escrituras.

  9. SOLUBILITY ENHANCEMENT OF CANDESARTAN CILEXETIL BY SELF EMULSIFYING DRUG DELIVERY SYSTEMS

    Directory of Open Access Journals (Sweden)

    M. Sunitha Reddy*, P. Srinivas Goud and S.S. Apte

    2012-07-01

    Full Text Available The present research work was aimed at the enhancement of solubility of Candesartan by Self Emulsifying Drug Delivery Systems (SEDDS. Candesartan is a BCS class II drug having low aqueous solubility and high permeability; hence its bioavailability is solubility rate limited. The saturated solubility of Candesartan in various oils and surfactants was determined. The excipients were screened and selected showing maximum solubility and compatibility for Candesartan. SEDDS formulations of Candesartan were developed using different Oils, Surfactants and Co-Surfactant combinations. Pseudoternary phase diagrams were constructed using Triplot V 4.1.2 software and applying Pseudoternary phase diagrams, microemulsification area was evaluated. Formulations were prepared based on phase diagrams using various proportions of oil, surfactants and co-surfactants. The formulations were screened visually for stability and phase separation. Seven formulations were selected for further evaluations like effect of dilution, freeze-thawing, emulsion droplet size and zeta potential. Among the seven formulations three were optimized and filled in hard gelatin capsules. The in-vitro dissolution studies of the SEDDS formulation were performed and the dissolution rate of SEDDS was compared with plain Candesartan (API. The results indicated that the solubility and dissolution rate of Candesartan was significantly higher than that of plain drug (API. The results of the present studies demonstrate that SEDDS can be used as a potential means for improving solubility, dissolution and bioavailability of Candesartan.

  10. Immunomodulatory effect of candesartan on indomethacin-induced gastric ulcer in rats.

    Science.gov (United States)

    Kamel, Rehab; El Morsy, Engy M; Awad, Azza S

    2012-12-01

    Non steroidal anti-inflammatory drugs (NSAIDs) induce gastric mucosal lesions in part by induction of oxidative stress as well as the activation of inflammatory cells and the production of proinflammatory cytokines. In this study, we examined the protective effect of candesartan (2 and 5 mg/kg) on indomethacin-induced gastric mucosa damage. Pretreatment with candesartan for 10 days reduced significantly the ulcer index induced by indomethacin injection. The preventive index of 2 mg/kg (76.74%) was higher than that of 5 mg/kg (65.11%). Both doses of candesartan were able to reduce significantly the stomach malondialdehyde content compared to indomethacin-treated group. Myeloperoxidase, tumor necrosis factor-α, cytokine-induced neutrophil chemoattractant gastric levels were significantly reduced by 2 mg/kg of candesartan more than 5 mg/kg. The Th1 cytokine interferon γ was also significantly reduced by both doses of candesartan compared to indomethacin injected group. On the other hand, indomethacin significant decreased the anti-inflammatory cytokine IL-10 gastric level. Pretreatment with candesartan (2 and 5 mg/kg) reversed this effect. In conclusion, the present study indicates that pretreatment with candesartan, can protect against the stomach injury induced by indomethacin through its antioxidant and immunomodulatory effects.

  11. Solid self-microemulsifying formulation for candesartan cilexetil.

    Science.gov (United States)

    Nekkanti, Vijaykumar; Karatgi, Pradeep; Prabhu, Raghavendra; Pillai, Raviraj

    2010-03-01

    Sparingly, water-soluble drugs such as candesartan cilexetil offer challenges in developing a drug product with adequate bioavailability. The objective of the present study was to develop and characterize self-microemulsifying drug delivery system (SMEDDS) of candesartan cilexetil for filling into hard gelatin capsules. Solubility of candesartan cilexetil was evaluated in various nonaqueous careers that included oils, surfactants, and cosurfactants. Pseudoternary phase diagrams were constructed to identify the self-microemulsification region. Four self-microemulsifying formulations were prepared using mixtures of oils, surfactants, and cosurfactants in various proportions. The self-microemulsification properties, droplet size, and zeta potential of these formulations were studied upon dilution with water. The optimized liquid SMEDDS formulation was converted into free flowing powder by adsorbing onto a solid carrier for encapsulation. The dissolution characteristics of solid intermediates of SMEDDS filled into hard gelatin capsules was investigated and compared with liquid formulation and commercial formulation to ascertain the impact on self-emulsifying properties following conversion. The results indicated that solid intermediates showed comparable rate and extent of drug dissolution in a discriminating dissolution medium as liquid SMEDDS indicating that the self-emulsifying properties of SMEDDS were unaffected following conversion. Also, the rate and extent of drug dissolution for solid intermediates was significantly higher than commercial tablet formulation. The results from this study demonstrate the potential use of SMEDDS as a means of improving solubility, dissolution, and concomitantly the bioavailability. PMID:20013081

  12. Effects Of Candesartan Cilexetil Drug And Allium Sativum On Certain Enzymes And Biochemical Parameters In Hyperlipidemic Mice

    Directory of Open Access Journals (Sweden)

    Mahmoud R. Mahmoud

    2004-06-01

    Full Text Available The present study was performed to investigate the possible correlation between the effects of candesartan cilexetil (3 mg/kg b.w. and garlic; allium sativum (100 mg/kg b.w. alone and in combination on high cholesterol diet (HCD male mice . Candesartan cilexetil alone and their combination with garlic were given orally to animals fed on hypercholesterolemic diet by gavage for 12 weeks . Results of this investigation showed that animals under high cholesterol diet exhibited some sort of changes in the blood, plasma and tissue levels of leukocytes,cholesterol, triglyceride and enzymes where they increased significantly while some decrease exhibited in heart weight, LDH-cholesterol and testosterone hormone compared with that of the normal diet animals. Candesartan cilexetil garlic or their combination significantly decreased the plasma and tissue levels of total cholesterol (TC, triglyceride (TG , while they increased significantly the levels of high density lipoprotein cholesterol ( HDL-C. On the contrary, candesartan and candesartan in combination with garlic decrease WBCs, neutrophils and platelets significantly in compared with that of the (HCD animals. This study included the total body and heart weights. Heart weight increased significantly in candesartan, garlic and their combination treated group. On the other hand, there were significantly decreases in body weight in candesartan, garlic and their combination compared with that of the high cholesterol diet treated animals. The effect of candesartan, garlic and their combination upon serum and liver levels of ALP, AST, ALT and ChE enzymes were investigated. Serum and liver ALP, AST, ALT and ChE were increased significantly in candesartan treated group but they decreased markedly in garlic and its combination with candesartan in serum and liver respectively compared with that of the high cholesterol diet animals. Candesartan decreased plasma level of testosterone while garlic and its

  13. Effect of candesartan treatment on left ventricular remodeling after aortic valve replacement for aortic stenosis

    DEFF Research Database (Denmark)

    Dahl, Jordi S; Videbaek, Lars; Poulsen, Mikael K;

    2010-01-01

    group had greater improvement in longitudinal LV systolic function assessed by tissue Doppler S' wave (0.6 +/- 0.1-cm/s increase in control group vs 1.4 +/- 0.1 cm/s in candesartan group, p = 0.01, p for trend = 0.02) and a decrease in LA volume (p for trend = 0.01). Treatment had no effect on diastolic......In hypertension, angiotensin receptor blockers can augment regression of left ventricular (LV) hypertrophy. It is not known whether this also is the case after aortic valve replacement (AVR) for severe aortic stenosis (AS). To test the hypothesis that treatment with candesartan in addition...... to conventional treatment is able to augment LV and left atrial (LA) reverse remodeling in patients with AS undergoing AVR, we studied 114 patients scheduled for AVR. Patients were randomized to treatment with candesartan 32 mg 1 time/day or conventional therapy immediately after AVR. Patients were followed...

  14. Improved simultaneous quantitation of candesartan and hydrochlorthiazide in human plasma by UPLC-MS/MS and its application in bioequivalence studies

    Institute of Scientific and Technical Information of China (English)

    Bhupinder Singh; Rama S. Lokhandae; Ashish Dwivedi; Sandeep Sharma; Naveen Dubey

    2014-01-01

    A validated ultra-performance liquid chromatography mass spectrometric method (UPLC-MS/MS) was used for the simultaneous quantitation of candesartan (CN) and hydrochlorothiazide (HCT) in human plasma. The analysis was performed on UPLC-MS/MS system using turbo ion spray interface. Negative ions were measured in multiple reaction monitoring (MRM) mode. The analytes were extracted using a liquid-liquid extraction (LLE) method by using 0.1 mL of plasma volume. The lower limit of quantitation for CN and HCT was 1.00 ng/mL whereas the upper limit of quantitation was 499.15 ng/mL and 601.61 ng/mL for CN and HCT respectively. CN d4 and HCT-13Cd2 were used as the internal standards for CN and HCT respectively. The chromatography was achieved within 2.0 min run time using a C18 Pheno-menex, Gemini NX (100 mm ~ 4.6 mm, 5 mm) column with organic mixture:buffer solution (80:20, v/v) at a flow rate of 0.800 mL/min. The method has been successfully applied to establish the bioequivalence of candesartan cilexetil (CNC) and HCT immediate release tablets with reference product in human subjects.

  15. Effects of candesartan on electrical remodeling in the hearts of inherited dilated cardiomyopathy model mice.

    Directory of Open Access Journals (Sweden)

    Fuminori Odagiri

    Full Text Available Inherited dilated cardiomyopathy (DCM is characterized by dilatation and dysfunction of the ventricles, and often results in sudden death or heart failure (HF. Although angiotensin receptor blockers (ARBs have been used for the treatment of HF, little is known about the effects on postulated electrical remodeling that occurs in inherited DCM. The aim of this study was to examine the effects of candesartan, one of the ARBs, on cardiac function and electrical remodeling in the hearts of inherited DCM model mice (TNNT2 ΔK210. DCM mice were treated with candesartan in drinking water for 2 months from 1 month of age. Control, non-treated DCM mice showed an enlargement of the heart with prolongation of QRS and QT intervals, and died at t1/2 of 70 days. Candesartan dramatically extended the lifespan of DCM mice, suppressed cardiac dilatation, and improved the functional parameters of the myocardium. It also greatly suppressed prolongation of QRS and QT intervals and action potential duration (APD in the left ventricular myocardium and occurrence of ventricular arrhythmia. Expression analysis revealed that down-regulation of Kv4.2 (Ito channel protein, KChIP2 (auxiliary subunit of Kv4.2, and Kv1.5 (IKur channel protein in DCM was partially reversed by candesartan administration. Interestingly, non-treated DCM heart had both normal-sized myocytes with moderately decreased Ito and IKur and enlarged cells with greatly reduced K+ currents (Ito, IKur IK1 and Iss. Treatment with candesartan completely abrogated the emergence of the enlarged cells but did not reverse the Ito, and IKur in normal-sized cells in DCM hearts. Our results indicate that candesartan treatment suppresses structural remodeling to prevent severe electrical remodeling in inherited DCM.

  16. Renal hemodynamic effects of candesartan in normal and impaired renal function in humans

    NARCIS (Netherlands)

    Buter, H; Navis, G; deZeeuw, D; deJong, PE

    1997-01-01

    The effects of angiotensin II type I receptor antagonist candesartan cilexitil, 8 mg once daily, were studied after single dose and after five days treatment in 17 hypertensive patients [median mean arterial pressure (MAP) 118 mm Hg, range 84 to 134] with renal function impairment of different sever

  17. Effect of Candesartan Cilexetil as a Sensitive and Effective Inhibitor of SHP-1 on Insulin Signaling Pathway

    Institute of Scientific and Technical Information of China (English)

    ZHANG Lei; ZHANG Shi-tao; ZHANG Xiao-ping; SUN Jing; WANG Yong-sen; LIU Yue-long; XUE Miao-miao

    2013-01-01

    The protein tyrosine phosphatases(PTPs) comprise a family of enzymes that specifically dephosphorylate tyrosyl residues.Among them,SHP-1 has been regarded as one of the best validated intracellular tyrosine phosphatases.Downregulation of SHP-1 has shown remarkable efficacy in improving insulin sensitivity in vivo in insulin signaling pathway.In this study,we found the role of Candesartan cilexetil targeting at SHP-1.The results indicate that Candesartan cilexetil was a competitive inhibitor to SHP-1(IC50=85.6 μmol/L and Ki=24 μmol/L).We also found that Candesartan cilexetil was more sensitive towards SHP-1 compared with other PTPs.Through the consequence of Western blotting,it showed that Candesartan cilexetil can strengthen the level of tyrosine phosphorylation of several key cellular proteins[such as insulin receptor(IR),insulin receptor substrate(IRS) and ERK] in insulin signaling pathway in HepG2 cells and improve the insulin sensitivity through inhibiting the protein phosphorylation of SHP-1.These findings showed that Candesartan cilexetil might be an important inhibitor of SHP-1 and had a great application potential in the treatment of diabetes through inhibiting the level of SHP-1 in insulin signaling pathway.

  18. Exposure to candesartan during the first trimester of pregnancy in type 1 diabetes: experience from the placebo-controlled diabetic retinopathy candesartan trials

    DEFF Research Database (Denmark)

    Porta, M; Hainer, J W; Jansson, S-O;

    2011-01-01

    . We report the experience from DIRECT (DIabetic REtinopathy and Candesartan Trials), three placebo-controlled studies designed to examine the effects of an ARB, candesartan, on diabetic retinopathy. METHODS: Over 4 years or longer, 178 normotensive women with type 1 diabetes (86 randomised......AIMS/HYPOTHESIS: The teratogenic consequences of angiotensin-converting enzyme inhibitors angiotensin receptor blockers (ARBs) during the second and third trimesters of pregnancy are well described. However, the consequences of exposure during the first trimester are unclear, especially in diabetes...... 'sick babies' and one cardiac malformation in the placebo group. CONCLUSIONS/INTERPRETATION: The risk for fetal consequences of ARBs in type 1 diabetes may not be high if exposure is clearly limited to the first trimester. Long-term studies in fertile women can be conducted with ARBs during pregnancy...

  19. Evaluation of calcium ion, hydroxyl ion release and pH levels in various calcium hydroxide based intracanal medicaments: An in vitro study

    OpenAIRE

    Punit Fulzele; Sudhindra Baliga; Nilima Thosar; Debaprya Pradhan

    2011-01-01

    Aims: Evaluation of calcium ion and hydroxyl ion release and pH levels in various calcium hydroxide based intracanal medicaments. Objective: The purpose of this study was to evaluate calcium and hydroxyl ion release and pH levels of calcium hydroxide based products, namely, RC Cal, Metapex, calcium hydroxide with distilled water, along with the new gutta-percha points with calcium hydroxide. Materials and Methods: The materials were inserted in polyethylene tubes and immersed in deionized wat...

  20. Candesartan cilexetil/hydrochlorothiazide combination treatment versus high-dose candesartan cilexetil monotherapy in patients with mild to moderate cardiovascular risk (CHILI Triple T

    Directory of Open Access Journals (Sweden)

    Bramlage P

    2011-02-01

    Full Text Available Gerd Bönner1, Bernhard Landers2, Peter Bramlage31Park-Klinikum Bad Krozingen, Germany; 2Internal Medicine Practice, Diabetes Center, Mayen, Germany; 3Institute for Cardiovascular Pharmacology and Epidemiology, Mahlow, GermanyBackground: Candesartan cilexetil has been shown to effectively reduce blood pressure and cardiovascular risk. Whether it is advantageous to combine candesartan cilexetil with low-dose hydrochlorothiazide (HCTZ or uptitrate it in cases of insufficient blood pressure control has not been fully investigated under routine clinical conditions.Methods: CHILI Triple T is a prospective, noninterventional, observational study. Patients with uncontrolled hypertension and added cardiovascular risk received a fixed-dose combination of candesartan cilexetil 16 mg and HCTZ 12.5 mg (combination therapy group or high-dose monotherapy with candesartan cilexetil 32 mg (high-dose monotherapy group.Results: A total of 4600 patients with a mean age of 63.1 ± 11.0 years, of which 44.7% were female, was included. The combination therapy group had 3337 patients, and the high-dose monotherapy group 1263 patients. Patients in both treatment groups were comparable with respect to age and gender, but patients receiving high-dose monotherapy had a slightly higher mean systolic blood pressure, more prior revascularizations, renal insufficiency, diabetic nephropathy, peripheral artery disease, and a lower ankle brachial index. The use of combination therapy resulted in a blood pressure reduction of -28.5 ± 13.8/-14.2 ± 9.4 mm Hg (P < 0.001 vs 160.2 ± 13.3/94.5 ± 8.2 mm Hg at baseline. The use of high-dose monotherapy reduced blood pressure by -29.73 ± 15.3/-14.1 ± 9.6 mm Hg (P < 0.001 vs 162.4 ± 14.7/94.7 ± 8.7 mm Hg at baseline. Differences in subgroups of patients defined by age, gender, body mass index, dyslipidemia, waist circumference, smoking, prior cardiovascular event, glomerular filtration rate, and microalbuminuria were minor

  1. 药用植物灵菊七的染色体核型研究%Study on Chromosomal Karyotypes of Medicinal Plant Gynura medica

    Institute of Scientific and Technical Information of China (English)

    范三微; 董丽辉; 凌庆枝; 屠晓玮; 林芝; 高莉莉; 魏兆军

    2012-01-01

    [目的]研究药用植物灵菊七(Gynura medica)的细胞染色体特点,并对其染色体核型进行分析.[方法]以灵菊七幼苗茎尖为材料,从上午6:30~10:30,每隔20 min取材一次,采用常规制片技术制片,显微镜观察中期分裂相细胞,对染色体完全分散开的细胞进行染色体计数及核型分析.[结果]在染色体分散良好的102个中期分裂相细胞中,有96.08%含20条染色体,3.92%含40条染色体;同时结果表明上午7:50~9:30取材较佳.[结论]G.medica为二倍体植物,体细胞含有10对染色体,核型公式为2n=2x=20 m,染色体核型属于1A型.该研究结果为国内首次报道.%[Objective] To study the chromosomal characteristics and karyotypes of G. medica[Method] Stem tip of G. medica seedlings were collected every 20 rain from 6:30 to 10:30 am, and all materials were treated and squashed for investigating chromcsouud number and karyotypcs analysis. [Result] In tote/102 stem tip cells in metaphase, 96.08% of cells are with 20 chromosomes, and 3.92% of cells are with 40 chromosomes. The optimal time for sampling was from 7:50 to 9:30 am. [Conclusion] G. medica is the diploid plant with 20 chromo-somcs. Karyotype analysis gets formula 2n = 2x = 20 re,and all 10 pairs of chromosomes belong to type IA. The article reported the chromo- somes characteristics of G. medica for the first time in China.

  2. The effects of angiotensin II receptor antagonist (candesartan on rat renal vascular resistance

    Directory of Open Access Journals (Sweden)

    Supatraviwat, J

    2004-05-01

    Full Text Available The present study aimed to investigate the action of angiotensin II (AII on renal perfusion pressure and renal vascular resistance using noncompetitive AT1-receptor antagonist (candesartan or CV 11974. Experiments were performed in isolated kidney of adult male Wistar rats. Kreb's Henseleit solution was perfused into the renal artery at the rate of 3.5 ml/min. This flow rate was designed in order to maintain renal perfusion pressure between 80-120 mm Hg. Dose-response relationship between perfusion flow rate and AII concentration were studied. Renal perfusion pressure in response to 1, 10 and 100 nM AII were increased from basal perfusion pressure of 94±8 mm Hg to 127±6, 157±12 and 190±16 mm Hg, respectively. Administration of perfusate containing 11.4 μM candesartan for 30 min had no effect on the basal perfusion pressure. However, this significantly reduced renal perfusion pressure in the presence of AII (1, 10 and 100 nM by 39%, 47% and 61%, (n=7, P<0.05 respectively. At the basal perfusion pressure, calculated renal vascular resistance was 27±2 mm Hg · min · ml-1. However, the vascular resistance were found to be 41±1, 45±2 and 47±2 mm Hg · min · ml-1 when 1, 10 and 100 nM AII were added. Moreover, this dose of candesartan also showed a significant decrease in renal vascular resistance at the corresponding doses of AII by 38%, 48% and 43%, (n=7, P<0.05 respectively. The higher dose of candesartan (22.7 μM completely inhibited the action of 1, 10 and 100 nM AII on renal vasoconstriction. These results may indicate that the action of AII on renal vascular resistance is via AT1-receptor, at least in rat isolated perfusion kidney.

  3. Candesartan and glycyrrhizin ameliorate ischemic brain damage through downregulation of the TLR signaling cascade.

    Science.gov (United States)

    Barakat, Waleed; Safwet, Nancy; El-Maraghy, Nabila N; Zakaria, Mohamed N M

    2014-02-01

    Stroke is the second leading cause of death in industrialized countries and the most frequent cause of permanent disability in adults worldwide. The final outcome of stroke is determined not only by the volume of the ischemic core, but also by the extent of secondary brain damage inflicted to penumbral tissues by brain swelling, impaired microcirculation, and inflammation. The only drug approved for the treatment ischemic stroke is recombinant tissue plasminogen activator (rt-PA). The current study was designed to investigate the protective effects of candesartan (0.15 mg/kg, orally) and glycyrrhizin (30 mg/kg, orally) experimentally-induced ischemic brain damage in C57BL/6 mice (middle cerebral artery occlusion, MCAO) in comparison to the effects of a standard neuroprotective drug (cerebrolysin, 7.5 mg/kg, IP). All drugs were administered 30 min before and 24h after MCAO. Both candesartan and glycyrrhizin ameliorated the deleterious effects of MCAO as indicated by the improvement in the performance of the animals in behaviour tests, reduction in brain infarction, neuronal degeneration, and leukocyte infiltration. In addition, MCAO induced a significant upregulation in the different elements of the TLR pathway including TLR-2 and TLR-4, Myd88, TRIF and IRF-3 and the downstream effectors TNF-α, IL-1β, IL-6 and NF-kB. All these changes were significantly ameliorated by treatment with candesartan and glycyrrhizin. The results of the current study represent a new indication for both candesartan and glycyrrhizin in the management of ischemic stroke with effects comparable to those of the standard neuroprotective drug cerebrolysin.

  4. Candesartan and glycyrrhizin ameliorate ischemic brain damage through downregulation of the TLR signaling cascade.

    Science.gov (United States)

    Barakat, Waleed; Safwet, Nancy; El-Maraghy, Nabila N; Zakaria, Mohamed N M

    2014-02-01

    Stroke is the second leading cause of death in industrialized countries and the most frequent cause of permanent disability in adults worldwide. The final outcome of stroke is determined not only by the volume of the ischemic core, but also by the extent of secondary brain damage inflicted to penumbral tissues by brain swelling, impaired microcirculation, and inflammation. The only drug approved for the treatment ischemic stroke is recombinant tissue plasminogen activator (rt-PA). The current study was designed to investigate the protective effects of candesartan (0.15 mg/kg, orally) and glycyrrhizin (30 mg/kg, orally) experimentally-induced ischemic brain damage in C57BL/6 mice (middle cerebral artery occlusion, MCAO) in comparison to the effects of a standard neuroprotective drug (cerebrolysin, 7.5 mg/kg, IP). All drugs were administered 30 min before and 24h after MCAO. Both candesartan and glycyrrhizin ameliorated the deleterious effects of MCAO as indicated by the improvement in the performance of the animals in behaviour tests, reduction in brain infarction, neuronal degeneration, and leukocyte infiltration. In addition, MCAO induced a significant upregulation in the different elements of the TLR pathway including TLR-2 and TLR-4, Myd88, TRIF and IRF-3 and the downstream effectors TNF-α, IL-1β, IL-6 and NF-kB. All these changes were significantly ameliorated by treatment with candesartan and glycyrrhizin. The results of the current study represent a new indication for both candesartan and glycyrrhizin in the management of ischemic stroke with effects comparable to those of the standard neuroprotective drug cerebrolysin. PMID:24378346

  5. Prevention of atrial fibrillation in patients with aortic valve stenosis with candesartan treatment after aortic valve replacement

    DEFF Research Database (Denmark)

    Dahl, J. S.; Videbaek, L.; Poulsen, M. K.;

    2013-01-01

    Background: Accumulating data has suggested that treatment with Angiotensin-II receptor antagonists can prevent the new onset of atrial fibrillation (AF). The aim of this study was to evaluate whether treatment with candesartan on top of conventional treatment could prevent new onset AF in patients...

  6. SOLUBILITY ENHANCEMENT OF CANDESARTAN CILEXETIL BY SELF EMULSIFYING DRUG DELIVERY SYSTEMS

    OpenAIRE

    M. Sunitha Reddy*, P. Srinivas Goud and S.S. Apte

    2012-01-01

    The present research work was aimed at the enhancement of solubility of Candesartan by Self Emulsifying Drug Delivery Systems (SEDDS). Candesartan is a BCS class II drug having low aqueous solubility and high permeability; hence its bioavailability is solubility rate limited. The saturated solubility of Candesartan in various oils and surfactants was determined. The excipients were screened and selected showing maximum solubility and compatibility for Candesartan. SEDDS formulations of Candes...

  7. Comparative Evaluation of Propolis, Metronidazole with Chlorhexidine, Calcium Hydroxide and Curcuma Longa Extract as Intracanal Medicament Against E.faecalis– An Invitro Study

    Science.gov (United States)

    Nair, Rashmi; Asrani, Hemant

    2015-01-01

    Introduction The increase of potential side effects and safety concerns of conventional medicaments have led to the recent popularity of herbal alternative medications. The herbal products are known for its high antimicrobial activity, biocompatibility, anti-inflammatory and antioxidant properties. Aim The purpose of this study was to investigate and compare the effectiveness of Propolis, Metronidazole with Chlorhexidine gel, Curcuma Longa and Calcium Hydroxide for elimination of E.faecalis bacteria in extracted teeth samples. Materials and Methods Ninety extracted single rooted intact teeth were taken for the study. Decoronation, removal of apices and chemomechanical preparation was done for all samples. These sterilized samples were then contaminated with pure culture of E.faecalis under laminar flow. The samples were incubated for a period of 21 days. The infected samples were assigned to 5 groups: Group I- Propolis; Group II- Metronidazole with Chlorhexidine gel; Group III- Calcium hydroxide; Group IV- Curcuma Longa; and control group- Saline. Efficacy of newer intracanal medicaments against E.faecalis were carried out in the samples at the end of 1, 2 & 5 days for each group with the help of colorimeter. Student paired t-test, ANOVA and multiple tukey test were used for statistical analysis. Results The value of optical density was statistically significant in all groups when compared to that of control group. Group I (Propolis) produced better antimicrobial efficacy followed by Chlorhexidine Metronidazole combination, Curcuma Longa and Calcium hydroxide. Conclusion Within the limitations of this study, it can be concluded that Propolis showed better antimicrobial properties against E.faecalis than other medicaments. PMID:26673857

  8. [Influence of compendium of Materia Medica on the materia medica in the late period of the Chosun Dynasty].

    Science.gov (United States)

    Oh, Chae-Kun

    2012-08-31

    In this paper, I investigated the influence of Compendium of Materia Medica (CM) on Records for Rural Life of Chosun Gentlemen (RRC), and refuted Miki Sakae's opinion, CM did not have much impact on the Materia Medica in the late period of the Chosun Dynasty. When Li Shizhen published CM, it resulted in a shift of mainstream of Materia Medica in Eastern Asia from Classified Emergency Materia Medica to CM and a new categorizing system of Materia Medica by CM led to the division of Materia Medica into medicine and natural history. It is obvious that doctors of the Chosun Dynasty also adopted the latest achievements of Materia Medica by CM, but so far there have been few studies to clarify this. Seo yugu was a scholar of the Realist School of Confucianism during the late period of the Chosun Dynasty, and RRC is his representative work. RRC is a massive encyclopedia of natural history that covers vast areas of science from agriculture, floriculture, writing and drawing, architecture, diet, and medicine, among others which absorbed the achievements of CM, the best Materia Medica book at that time. Miki Sakae also highly regarded the encyclopedic knowledge of RRC, but devalued the results of Materia Medica. He only described a part of RRC's Materia Medica, nurturing volume, on the view of life nurturing and mentioned that it had been strongly influenced by China. According to this study, a large portion of RRC, especially regarding Materia Medica, depends on CM. Seo yugu had accepted the categorizing system and new medicinal information of CM, at the same time he modified the categorizing system of CM practically by the subject of each volume of RRC. We can find many quotations of CM except the nurturing volume, but other books, Treasured Mirror of Eastern Medicine, Materia Medica for Relief of Famines are also quoted. Furthermore, Seo yugu emphasized the differences of natural environments between Chosun and China, and specified the editing criteria, "to be useful in

  9. Effects of candesartan in hypertensive patients with type 2 diabetes mellitus on inflammatory parameters and their relationship to pulse pressure

    Directory of Open Access Journals (Sweden)

    Sakamoto Masaya

    2012-10-01

    Full Text Available Abstract Background Angiotensin receptor blockers (ARBs are reported to provide direct protection to many organs by controlling inflammation and decreasing oxidant stress in patients without arteriosclerosis. This study aimed to evaluate (1 whether an ARB (candesartan decreases values for inflammatory parameters in hypertensive patients with type 2 diabetes mellitus of long duration accompanied by arteriosclerosis and (2 whether there any predictors of which patients would receive the benefits of organ protection by candesartan. Methods We administered candesartan therapy (12 mg daily for 6 months and evaluated whether there was improvement in serum inflammatory parameters high molecular weight adiponectin (HMW-ADN, plasminogen activator inhibitor-1 (PAI-1, highly sensitive C-reactive protein (Hs-CRP, vascular cell adhesion molecule-1 (VCAM-1 in serum and urinary-8-hydroxydeoxyguanosine (U-8-OHdG. We then analyzed the relationship between the degree of lowering of blood pressure and inflammatory factors and the relationship between pulse pressure and inflammatory factors. Finally, we analyzed predictive factors in patients who received the protective benefit of candesartan. Results After 6 months of treatment, significant improvements from baseline values were observed in all patients in HMW-ADN and PAI-1 but not in Hs-CRP, VCAM-1 and U-8-OHdG. Multilinear regression analysis was performed to determine which factors could best predict changes in HMW-ADN and PAI-1. Changes in blood pressure were not significant predictors of changes in metabolic factors in all patients. We found that the group with baseline pulse pressure Conclusions Candesartan improved inflammatory parameters (HMW-ADN and PAI-1 in hypertensive patients with type 2 diabetes mellitus of long duration independent of blood pressure changes. Patients with pulse pressure Trial registration UMIN000007921

  10. Blood pressure-independent effect of candesartan on cardio-ankle vascular index in hypertensive patients with metabolic syndrome

    Directory of Open Access Journals (Sweden)

    Kanako Bokuda

    2010-07-01

    Full Text Available Kanako Bokuda1, Atsuhiro Ichihara1,2, Mariyo Sakoda1, Asako Mito1, Kenichiro Kinouchi1, Hiroshi Itoh11Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Endocrinology and Anti-Aging Medicine, Keio University School of Medicine, Tokyo, JapanAbstract: Angiotensin receptor blockers (ARBs are known to reduce the cardiovascular risk in hypertensive patients. This study was designed to examine the effect of an ARB candesartan on subclinical atherosclerosis assessed by cardio-ankle vascular index (CAVI in comparison with calcium channel blockers (CCBs alone in hypertensive patients with metabolic syndrome (MetS. A total of 53 consecutive hypertensive patients with MetS were randomly assigned to the candesartan group, in which candesartan was added on, or the CCBs group, in which CCBs were added on. Clinical and biological parameters were obtained before and after the 12-month treatment period. The primary measure of efficacy was the %change in CAVI. When treated with candesartan, but not CCBs, CAVI significantly decreased from 8.7 to 7.7 by 11%. Blood pressure (BP significantly decreased with both treatments, but the differences between groups were not significant. The changes in other parameters remained unchanged in both the groups. Analysis of covariance found that both the BP reduction and the therapy difference contributed to the decrease in CAVI, but the BP reduction was not involved in the decrease in CAVI caused by the difference in the therapy. Candesartan may be a better antihypertensive drug than CCBs to that subclinical atherosclerosis of patients with MetS.Keywords: albuminuria, ambulatory blood pressure, calcium channel blockers, carotid ­intima-media thickness

  11. Effect of calcium hydroxide and triple antibiotic paste as intracanal medicaments on the incidence of inter-appointment flare-up in diabetic patients: An in vivo study

    OpenAIRE

    Swathi Pai; A R Vivekananda Pai; Thomas, Manuel S; Vishal Bhat

    2014-01-01

    Aim: To evaluate and compare the effect of antibacterial intracanal medicaments on inter-appointment flare-up in diabetic patients. Materials and Methods: Fifty diabetic patients requiring root canal treatment were assigned into groups I, II, and III. In group I, no intracanal medicament was placed. In groups II and III, calcium hydroxide and triple antibiotic pastes were placed as intracanal medicaments, respectively. Patients were instructed to record their pain on days 1, 2, 3, 7, and ...

  12. Removal efficiency of calcium hydroxide intracanal medicament with RinsEndo system in comparison with passive ultrasonic irrigation, an in vitro study

    Directory of Open Access Journals (Sweden)

    Abbass Ali Khademi

    2015-01-01

    Full Text Available Background: Different techniques have been introduced to improve removing the calcium hydroxide intra-canal dressing. The purpose of this study was to compare the efficiency of passive ultrasonic irrigation (PUI and RinsEndo system in the removal of calcium hydroxide from root canal system. Materials and Methods: Access cavities were prepared in 50 single-rooted anterior teeth. Cleaning and shaping were done using the Flexmaster rotary system up to size no. 30, 6%. The canals were filled with injectable calcium hydroxide (calcipex. After 7 days, the calcium hydroxide were retrieved using RinsEndo system in Group 1 (n = 20, with PUI system in Group 2 (n = 20. In positive control group (n = 5, no irrigation was performed. In negative control group (n = 5, root canals were not filled with any medicament. Following the removal of the calcium hydroxide with these two systems, teeth were split buccolingually into two sections and every third of the root canals was evaluated under stereomicroscope (×30 to analyze the residual medicament in each segment. Data were analyzed using the Kruskal-Wallis and Mann-Whitney tests (P < 0.05. Results: There was no significant difference in the removal of calcium hydroxide between RinsEndo and PUI at cervical (P = 0.67, middle (P = 0.51 and apical (P = 0.75 part of the root canals. Conclusion: None of the irrigation techniques was able to completely remove calcium hydroxide from the root canal system.

  13. Antimutagenicity and Anticancer Effects of Citrus Medica Fruit Juice

    Directory of Open Access Journals (Sweden)

    Majd Ahmad

    2009-10-01

    Full Text Available Currently cancer is considered as one of the main factors of mortality globally. Many chemicals in our environment can cause genetic mutations and are potentially responsible for millions of cancer-related deaths. Nowadays the scientists are looking for food materials which can potenthially prevent the cancer occurrence. The purpose of this research is to examine antimutagenicity and anticancer effect of Citrus Medica fruit juice.In present study human astrocytoma cancer cells were cultured in DMEM (Gibco,supplemented with 10% fetal calf serum,peniciline-streptomycin,L-glutamine and incubated at 37 ºC for 2 days.In addition cancer cell line were treated by half-ripe and ripe Citrus Medica fruit juice and cellular vital capacity was determined by MTT. The Citrus Medica fruit juice was subsequenthy evaluated in terms of antimutagenicity and anticancer properties by a standard reverse mutation assay (Ames Test. This was performed with histidine auxotroph strain of Salmonella typhimurium (TA100 .Thus, it requires histidine from a foreign supply to ensure its growth.The aforementioned strain gives rise to reverted colonies when expose to carcinogen substance (Sodium Azide. During MTT, human astrocytoma cell line revealed to have a meaningful cell death when compared with controls (P<0.01. In Ames Test the fruit juice prevented the reverted mutations and the hindrance percent of half-ripe Citrus Medica was 71.7% and ripe Citrus Medica was 34.4% in antimutagenicity test and this value in anticancer test was 83.3% and 50% in half-ripe Citrus Medica and ripe Citrus Medica respectively.This is the first study that have revealed antimutagenicity and anticancer effect of Citrus Medica fruit juice and the effects were higher in half-ripe Citrus Medica in comparison to the riprned one.

  14. Preparation of Candesartan and Atorvastatin Nanoparticles by Solvent Evaporation

    Directory of Open Access Journals (Sweden)

    Josef Jampilek

    2012-11-01

    Full Text Available The solubility, absorption and distribution of a drug are involved in the basic aspects of oral bioavailability Solubility is an essential characteristic and influences the efficiency of the drug. Over the last ten years, the number of poorly soluble drugs has steadily increased. One of the progressive ways for increasing oral bioavaibility is the technique of nanoparticle preparation, which allows many drugs to thus reach the intended site of action. Candesartan cilexetil and atorvastatin, belonging to class II of the biopharmaceutical classification system, were chosen as model active pharmaceutical ingredients in this study. Forty samples were prepared either by antisolvent precipitation/solvent evaporation method or by the emulsion/solvent evaporation technique with various commonly used surface-active excipients as nanoparticle stabilizers. All samples were analyzed by means of dynamic light scattering. The particle size of the determined 36 nanoparticle samples was to 574 nm, whereas 32 samples contained nanoparticles of less than 200 nm. Relationships between solvents and excipients used and their amount are discussed. Based on the results the investigated solvent evaporation methods can be used as an effective and an affordable technique for the preparation of nanoparticles.

  15. [The Seongho () School's Study of the Ancient Learning () and Its Influence on the Debate about Materia Medica in the Late Joseon Dynasty].

    Science.gov (United States)

    Cho, Sung-San

    2015-08-01

    This study will determine the ways in which the ancient learning (gu xue, ) scholarship of the Seongho School, and its interest in the materia medica (ben cao xue, ) were related during the late Joseon period. The Seongho School centered its studies mainly on classical Chinese texts of the Han (206 BC-AD 220) and pre-Han (?-221 BC) (xian-qin lianghan, ) periods rather than those of the Tang and Song dynasties (618-1279). gu xue scholarship emerged during the Ming dynasty era (1368 -1644) as an alternative to the scholarly trends of the Song dynasty, which were dependent on Zhu Xi's (, 1130-1200) Neo-Confucianism and its interpretation of Han and pre-Han classical Chinese texts. This scholarly trend influenced Korean and Japanese literature, philosophy, and even medicine from the seventeenth through the nineteenth centuries. Focusing on Korean scholarship, we find a great deal of research regarding the influence of gu xue on Korean classical Chinese literature and Confucian philosophy in the late Joseon period; however, no study has examined how this style of scholarship influenced the field of medicine during the same period. This study will investigate how the intellectuals of the Seongho School, who did the most to develop gu xue among Joseon intellectuals, were influenced by this style of scholarship in their study of the materia medica. Jeong Yak-yong (1762-1836), the representative intellectual of the Seongho School, did not focus on complicated metaphysical medical theories, such as the Yin-Yang and Five Elements theory (yin yang wu xing shui, ) or the Five Movements and Six Atmospheres theory (wu yun liu qi shui, ). Instead, his interests lay in the exact diagnoses of diseases and meticulous herbal prescriptions which formed an essential part of the Treatise on Exogenous Febrile Disease (Shang han lun, ) written by Zhang Zhungjing (, 150-219) in the Han dynasty. The Treatise was compatible with the scholarly purpose of gu xue in that they both

  16. Cost-effectiveness of candesartan versus losartan in the primary preventive treatment of hypertension

    Directory of Open Access Journals (Sweden)

    Granström O

    2012-11-01

    Full Text Available Ola Granström,1 Lars-Åke Levin,2 Martin Henriksson11AstraZeneca Nordic, Södertälje, 2Center for Medical Technology Assessment, Linköping University, Linköping, SwedenBackground: Although angiotensin receptor blockers have different receptor binding properties, no comparative randomized studies with cardiovascular event endpoints have been performed for this class of drugs. The aim of this study was to assess the long-term cost-effectiveness of candesartan (Atacand® versus generic losartan in the primary preventive treatment of hypertension.Methods: A decision-analytic model was developed to estimate costs and health outcomes over a patient's lifetime. Data from a clinical registry study were used to estimate event rates for cardiovascular complications, such as myocardial infarction and heart failure. Costs and quality of life data were from published sources. Costs were in Swedish kronor and the outcome was quality-adjusted life-years (QALYs. Results: Due to reduced rates of cardiovascular complications, candesartan was associated with a QALY gain and lower health care costs compared with generic losartan (0.053 QALYs gained and reduced costs of approximately 4700 Swedish kronor for women; and 0.057 QALYs gained and reduced costs of approximately 4250 Swedish kronor for men. This result was robust in several sensitivity analyses.Conclusion: When modeling costs and health outcomes based on event rates for cardiovascular complications from a real-world registry study, candesartan appears to bring a QALY gain and a reduction in costs compared with generic losartan in the primary preventive treatment of hypertension in Sweden.Keywords: hypertension, angiotensin receptor blockers, cost-effectiveness, decision analysis

  17. DYNAMICS OF PARAMETERS OF PROINFLAMMATORY ACTIVATION IN PATIENTS WITH HYPERTENSION UNDER INFLUENCE OF CANDESARTAN THERAPY

    OpenAIRE

    Vizir, V. A.; Sadomov, A. S.; Goncharov, O. V.

    2014-01-01

    Aim. Proinflammatory activation is one of the possible pathogenetic mechanisms of formation and progression of hypertension. 107 patients with essential hypertension (EH) II stage was included into the study of the pro-inflammatory activation.Methods and results. Levels of C-reactive protein (CP), α-tumor necrosis factor (α-TNF) and soluble form of intercellular adhesion molecule-1 (sICAM-1) in the serum were studied by ELISA before and after 12 weeks of treatment with candesartan. 31 healthy...

  18. Use of compounded dispersing media for extemporaneous pediatric syrups with candesartan cilexetil and valsartan

    Directory of Open Access Journals (Sweden)

    Musko Monika

    2014-12-01

    Full Text Available Available tablets or capsules for adults are often used to prepare extemporaneously formulated medicines appropriate for children. The most acceptable drug forms in pediatric population are oral liquids and pharmacists use commercial dispersing media to compound syrups from an active substance or from tablets available on the market. In many countries ready-to-use dispersing media are not available or refunded, but pharmacists can use other compounded media, providing their compatibility and stability are proven. The aim of this study was to formulate and evaluate the stability of syrups with candesartan cilexetil (1 mg mL-1 and valsartan (4 mg mL-1 extemporaneously prepared using commercial tablets (Diovan® and Atacand®. The following three different suspending media, which could be easily made in a pharmacy, were investigated: V1 - with xanthan gum (0.5 %, V2 - the USP/NF vehicle for oral solution and V3 - the medium based on a simple sucrose syrup. The stability of preparations was studied during 35 days of storage in a dark place at controlled temperature of 25 and 4 °C. During the study, microscopic observation was carried out and pH, viscosity, and concentration of candesartan cilexetil and valsartan were analyzed. Syrups with valsartan prepared with V2 and V3 media were stable for 3 or 4 weeks when stored at 25 °C, while syrups with candesartan were stable for as long as 35 days. For syrups prepared using V1 medium, the 14-day expiry date was not achieved because of microbial deterioration.

  19. Feasibility of combined treatment with enalapril and candesartan in advanced chronic kidney disease

    DEFF Research Database (Denmark)

    Høj Nielsen, Arne; Strandgaard, Svend; Kamper, Anne-Lise;

    2010-01-01

    BACKGROUND: Dual blockade of the renin-angiotensin system (RAS) has been claimed to have a specific renal protective effect in chronic kidney disease (CKD). The present short-term study reports on the feasibility of dual blockade in a consecutive group of patients with CKD stage 3-5. METHODS: For...... blockade with 20 mg enalapril and 16 mg candesartan daily, primarily due to loss of renal function or hypotension. Hyperkalemia could be managed in most patients. Caution is recommended when giving this treatment to patients with advanced CKD....

  20. Angiotensin receptor blockade in acute stroke. The Scandinavian Candesartan Acute Stroke Trial

    DEFF Research Database (Denmark)

    Sandset, Else Charlotte; Murray, Gordon; Boysen, Gudrun;

    2010-01-01

    . Secondary outcome variables: Secondary effect variables include • the Barthel index (functional status) • EuroQol (quality of life) and • Mini-mental state examination (cognition) at 6-months • Health economic costs during the first 6-months FUNDING: The Scandinavian Candesartan Acute Stroke Trial receives......-European countries: Norway, Sweden, Denmark, Belgium, Germany, Poland, Lithuania, Estonia and Finland. STUDY OUTCOMES: There are two co-primary effect variables: • Functional status at 6-months, measured by the modified Rankin Scale, and • vascular death, myocardial infarction or stroke during the first 6-months...

  1. [Ecological agriculture: future of Good Agriculture Practice of Chinese materia medica].

    Science.gov (United States)

    Guo, Lan-ping; Zhou, Liang-yun; Mo, Ge; Wang, Sheng; Huang, Lu-qi

    2015-09-01

    Based on the ecological and economic problems in Good Agriculture Practice (GAP) of Chinese material medica, we introduced the origin, concept, features and operative technology of eco-agriculture worldwide, emphasizing its modes on different biological levels of landscape, ecosystem, community, population, individual and gene in China. And on this basis, we analyzed the background and current situation of eco-agriculture of Chinese materia medica, and proposed its development ideas and key tasks, including: (1) Analysis and planning of the production pattern of Chinese material medica national wide. (2) Typical features extraction of regional agriculture of Chinese materia medica. (3) Investigation of the interaction and its mechanism between typical Chinese materia medica in each region and the micro-ecology of rhizosphere soil. (4) Study on technology of eco-agriculture of Chinese materia medica. (5) Extraction and solidification of eco-agriculture modes of Chinese materia medica. (6) Study on the theory of eco-agriculture of Chinese materia medica. Also we pointed out that GAP and eco-agriculture of Chinese material medica are both different and relative, but they are not contradictory with their own features. It is an irresistible trend to promote eco-agriculture in the GAP of Chinese material medica and coordinate ecological and economic development.

  2. Blood pressure-independent effect of candesartan on cardio-ankle vascular index in hypertensive patients with metabolic syndrome

    OpenAIRE

    Bokuda,

    2010-01-01

    Kanako Bokuda1, Atsuhiro Ichihara1,2, Mariyo Sakoda1, Asako Mito1, Kenichiro Kinouchi1, Hiroshi Itoh11Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Endocrinology and Anti-Aging Medicine, Keio University School of Medicine, Tokyo, JapanAbstract: Angiotensin receptor blockers (ARBs) are known to reduce the cardiovascular risk in hypertensive patients. This study was designed to examine the effect of an ARB candesartan on subclinical atheroscle...

  3. Effect of candesartan monotherapy on lipid metabolism in patients with hypertension: a retrospective longitudinal survey using data from electronic medical records

    Directory of Open Access Journals (Sweden)

    Nishida Yayoi

    2010-08-01

    Full Text Available Abstract Background Studies focusing on the add-on effects of angiotensin II type 1 receptor blockers (ARBs other than their antihypertensive effect are receiving attention. However, the effects of prolonged administration of ARBs on lipid metabolism in clinical cases are unclear. Our aims were to survey the changes in plasma lipid profile in patients with hypertension over a one-year period, and to examine the correlations between these values and the time after the start of ARB monotherapy with candesartan. Methods We carried out candesartan monotherapy in patients with mild to moderate hypertension and examined the longitudinal changes in plasma lipid profile. Data from 405 patients for triglyceride (TG, 440 for total cholesterol (TC, 313 for high density lipoprotein cholesterol (HDL-C and 304 for low density lipoprotein cholesterol (LDL-C were obtained from the electronic medical records (EMRs in the Clinical Data Warehouse (CDW of Nihon University School of Medicine (NUSM. The inverse probability of treatment weighting (IPTW method (calculated from the inverse of the propensity score was used to balance the covariates and reduce bias in each treatment duration. Linear mixed effects models were used to analyse the relationship between these longitudinal data of blood examinations and covariates of patient sex, age, diagnosis of diabetes mellitus (DM and duration of candesartan monotherapy. Results Plasma HDL-C level was associated with sex, duration of treatment, and interaction of sex and treatment duration, but not with age or diagnosis of DM. HDL-C level was significantly decreased during the 6~9 months period (p = 0.0218 compared with baseline. TG and TC levels were associated with sex, but not with age, diagnosis of DM or treatment duration. LDL-C level was not associated with any covariate. Analysis of the subjects divided by sex revealed a decrease in HDL-C in female subjects (during the 6~9 months period: p = 0.0054, but not in male

  4. Candesartan ameliorates acute myocardial infarction in rats through inducible nitric oxide synthase, nuclear factor‑κB, monocyte chemoattractant protein‑1, activator protein‑1 and restoration of heat shock protein 72.

    Science.gov (United States)

    Lin, Xuefeng; Wu, Min; Liu, Bo; Wang, Junkui; Guan, Gongchang; Ma, Aiqun; Zhang, Yong

    2015-12-01

    Candesartan, an angiotensin II type 1 receptor antagonist, has a variety of biological activities, including antioxidant, anti‑inflammatory and anticancer activities, with specific pharmacological effects. The present study investigated the mechanisms and protective effect of candesartan on acute myocardial infarction in rats. Male Wistar rats (8‑week‑old) were induced as a model of acute myocardial infarction and treated with candesartan (0.25 mg/kg) for 2 weeks. The present study first measured the activities of casein kinase (CK), the MB isoenzyme of creatine kinase (CK‑MB) and lactate dehydrogenase (LDH), the level of cardiac troponin T (cTnT) and infarct size. Subsequently, western blot analysis was performed to analyze the protein expression levels of inducible nitric oxide synthase (iNOS) and heat shock protein 72 (HSP72) in the rats. An enzyme linked immunosorbent assay was used to detect iNOS and nuclear factor‑κB (NF‑κB) activity. In addition, gene expression levels of monocyte chemotactic protein‑1 (MCP‑1) and activating protein‑1 (AP‑1) were determined using reverse transcription‑quantitative polymerase chain reaction analysis. Finally, the activities of caspase‑3 and caspase‑9 were examined using colorimetric assay kits. In the serum of the rat model of acute myocardial infarction, candesartan significantly increased the activities of CK, CK‑MB and LDH, and the level of cTnT. The infarction size was perfected by candesartan treatment. Candesartan significantly reduced the protein expression and activity of iNOS, the activity of NF‑κB p65, and the gene expression levels of MCP‑1 and AP‑1 in the rat model of acute myocardial infarction. Candesartan increased the protein expression of HSP‑72 in the acute myocardial infarction rat model. However, candesartan did not effect the levels of caspase‑3 or caspase‑9 in the rat model of acute myocardial infarction. These results suggested that candesartan ameliorates

  5. Candesartan ameliorates acute myocardial infarction in rats through inducible nitric oxide synthase, nuclear factor‑κB, monocyte chemoattractant protein‑1, activator protein‑1 and restoration of heat shock protein 72.

    Science.gov (United States)

    Lin, Xuefeng; Wu, Min; Liu, Bo; Wang, Junkui; Guan, Gongchang; Ma, Aiqun; Zhang, Yong

    2015-12-01

    Candesartan, an angiotensin II type 1 receptor antagonist, has a variety of biological activities, including antioxidant, anti‑inflammatory and anticancer activities, with specific pharmacological effects. The present study investigated the mechanisms and protective effect of candesartan on acute myocardial infarction in rats. Male Wistar rats (8‑week‑old) were induced as a model of acute myocardial infarction and treated with candesartan (0.25 mg/kg) for 2 weeks. The present study first measured the activities of casein kinase (CK), the MB isoenzyme of creatine kinase (CK‑MB) and lactate dehydrogenase (LDH), the level of cardiac troponin T (cTnT) and infarct size. Subsequently, western blot analysis was performed to analyze the protein expression levels of inducible nitric oxide synthase (iNOS) and heat shock protein 72 (HSP72) in the rats. An enzyme linked immunosorbent assay was used to detect iNOS and nuclear factor‑κB (NF‑κB) activity. In addition, gene expression levels of monocyte chemotactic protein‑1 (MCP‑1) and activating protein‑1 (AP‑1) were determined using reverse transcription‑quantitative polymerase chain reaction analysis. Finally, the activities of caspase‑3 and caspase‑9 were examined using colorimetric assay kits. In the serum of the rat model of acute myocardial infarction, candesartan significantly increased the activities of CK, CK‑MB and LDH, and the level of cTnT. The infarction size was perfected by candesartan treatment. Candesartan significantly reduced the protein expression and activity of iNOS, the activity of NF‑κB p65, and the gene expression levels of MCP‑1 and AP‑1 in the rat model of acute myocardial infarction. Candesartan increased the protein expression of HSP‑72 in the acute myocardial infarction rat model. However, candesartan did not effect the levels of caspase‑3 or caspase‑9 in the rat model of acute myocardial infarction. These results suggested that candesartan ameliorates

  6. Stability and Accuracy Assessment of Identification of Traditional Chinese Materia Medica Using DNA Barcoding: A Case Study on Flos Lonicerae Japonicae

    Directory of Open Access Journals (Sweden)

    Dianyun Hou

    2013-01-01

    Full Text Available DNA barcoding is a novel molecular identification method that aids in identifying traditional Chinese materia medica using traditional identification techniques. However, further study is needed to assess the stability and accuracy of DNA barcoding. Flos Lonicerae Japonicae, a typical medicinal flower, is widely used in China, Korea, and other Southeast Asian countries. However, Flos Lonicerae Japonicae and its closely related species have been misused and traded at varying for a wide range of prices. Therefore, Flos Lonicerae Japonicae must be accurately identified. In this study, the ITS2 and psbA-trnH regions were amplified by polymerase chain reaction (PCR. Sequence assembly was performed using CodonCode Aligner V 3.5.4. The intra- versus inter-specific variations were assessed using six metrics and “barcoding gaps.” Species identification was conducted using BLAST1 and neighbor-joining (NJ trees. Results reveal that ITS2 and psbA-trnH exhibited an average intraspecific divergence of 0.001 and 0, respectively, as well as an average inter-specific divergence of 0.0331 and 0.0161. The identification efficiency of ITS2 and psbA-trnH evaluated using BLAST1 was 100%. Flos Lonicerae Japonicae was formed into one clade through the NJ trees. Therefore, Flos Lonicerae Japonicae can be stably and accurately identified through the ITS2 and psbA-trnH regions, respectively.

  7. The angiotensin-receptor blocker candesartan for treatment of acute stroke (SCAST)

    DEFF Research Database (Denmark)

    Sandset, Else Charlotte; Bath, Philip M W; Boysen, Gudrun;

    2011-01-01

    BACKGROUND: Raised blood pressure is common in acute stroke, and is associated with an increased risk of poor outcomes. We aimed to examine whether careful blood-pressure lowering treatment with the angiotensin-receptor blocker candesartan is beneficial in patients with acute stroke and raised...... blood pressure. METHODS: Participants in this randomised, placebo-controlled, double-blind trial were recruited from 146 centres in nine north European countries. Patients older than 18 years with acute stroke (ischaemic or haemorrhagic) and systolic blood pressure of 140 mm Hg or higher were included...... to treatment allocation. There were two co-primary effect variables: the composite endpoint of vascular death, myocardial infarction, or stroke during the first 6 months; and functional outcome at 6 months, as measured by the modified Rankin Scale. Analyses were by intention to treat. The study is registered...

  8. 佛手花抗氧化活性研究%Study on Antioxidative Activities of Flower of Cit rus medica

    Institute of Scientific and Technical Information of China (English)

    杨新周; 郝志云; 杨子仙; 朱以常; 董毅; 林惠昆

    2014-01-01

    In order to further comprehensive utilization of flower of Citrus medica ,the scavenging activities of DPPH free radical and hydroxyl radical were determined ,and they were compared with quercetin ,kaempferol , caffeic acid ,rutin ,gallic acid and p-coumaric acid .The results showed that the scavenging activities of DPPH free radical was p-coumaric acid< extract from flower of Citrus medica< vanillic acid< rutin< caffeic acidmedicamedica had good antioxidant ac-tivity and could be a good natural antioxidant .%为进一步综合利用佛手花,该研究测定了其对DPPH自由基和羟自由基的清除能力,并与对照槲皮素、山奈酚、咖啡酸、芦丁、没食子酸和对香豆酸进行比较。结果表明:各物质清除DPPH自由基的能力为:对香豆酸<佛手花提取物<香草酸<芦丁<咖啡酸<没食子酸。清除羟自由基的能力为:芦丁<咖啡酸<佛手花提取物<山奈酚<槲皮素。说明佛手花提取物具有很好的抗氧化活性,是一种良好的天然抗氧化剂。

  9. Mixed solvency concept in reducing surfactant concentration of self-emulsifying drug delivery systems of candesartan cilexetil using D-optimal mixture design

    OpenAIRE

    Chandna Chandan; R K Maheshwari

    2013-01-01

    The objective of this present study was to explore the utility of "mixed solvency" concept to enhance the solubility of poorly-water soluble drug, candesartan cilexetil (CC) in modified solubilizer system. The objective of this paper is to reduce the surfactant concentration traditionally involved in the formulation of self-emulsifying drug delivery systems (SEDDS) by proposing an alternate system of solubilizer to provide novel surfactant/cosurfactant system, to aid traditionally involved co...

  10. Antimutagenicity and Anticancer Effects of Citrus Medica Fruit Juice

    OpenAIRE

    Majd Ahmad; Falahian Fathollah; Mehrabian Sedigheh; Hashemi Mehrdad; Ardeshiry Lajimi Abdolreza; Entezari Maliheh

    2009-01-01

    Currently cancer is considered as one of the main factors of mortality globally. Many chemicals in our environment can cause genetic mutations and are potentially responsible for millions of cancer-related deaths. Nowadays the scientists are looking for food materials which can potenthially prevent the cancer occurrence. The purpose of this research is to examine antimutagenicity and anticancer effect of Citrus Medica fruit juice.In present study human astrocytoma cancer cells were cultured i...

  11. [AII antagonists (candesartan and irbesartan) in the treatment of cardiovascular diseases].

    Science.gov (United States)

    Spinar, J; Vítovec, J

    2012-10-01

    Treatment of hypertension with angiotensin II receptor antagonists (AIIA) was first limited to diabetics and patients with microalbuminuria. So far, results of several large clinical trials with AIIAs were published, confirming significant renoprotective effect of these agents compared to placebo (RENAAL and IRMA), amlodipin (MARVAL and IDNT) and a combination of ACEI and AIIA (CALM). In 2002, results of 2 large comparator studies in hypertension were published: LIFE - Losartan Intervention For Endpoints and SCOPE - the Study on COgnition and Prognosis in Elderly hypertensives. In 2003, a series of the CHARM studies involving patients with heart failure were published and, from than, AIIA have been used as an alternative to ACEI or in a combination with ACEI. MOSES study - Morbidity and mortality after stroke, eprosartan compared with nitrendipine for secondary prevention - results were published in 2005 and ONTARGET study, focusing on secondary prevention of ischemic heart disease, was published in 2008. The CORD study - Comparison of recommended doses - and the ACTIVE I study (AF Clopidogrel Trial with Irbesartan for prevention of Vascular Events) were published in 2009. Candesartan was used in the CALM, SCOPE, RESOLVED and CHARM studies, irbesartan in the IRMA, IDNT and ACTIVE I. PMID:23121062

  12. Discoloration of Roots Caused by Residual Endodontic Intracanal Medicaments

    Directory of Open Access Journals (Sweden)

    Belinda Kuan-Jung Chen

    2014-01-01

    Full Text Available Aims. This study examined the extent to which intervisit corticosteroid-based antibiotic pastes (CAP medicaments contribute to staining of tooth structure after attempted removal by irrigation techniques. Methods. A total of 140 roots were prepared and the canals were filled with Ledermix paste (demeclocycline, Odontopaste (clindamycin, and Doxypaste (doxycycline. The pastes were removed after 2 or 4 weeks of storage in the dark using EDTA and NaOCl with either a 27-gauge-slotted needle or an EndoActivator (Dentsply. The roots were then exposed to an intense light source for 30 minutes each week and photographed after a further 1, 3, or 6 months. Digital images were standardized and data for changes in luminosity were analysed using repeated measures ANOVA and a post hoc test. Results. Removal of the medicament did not prevent later discolouration. There was no significant difference between the paste removal methods. Ledermix paste caused the greatest darkening compared to the untreated controls, for both application periods and both methods of removal. Doxypaste and Odontopaste caused less darkening than Ledermix. Conclusion. Medicaments that stain teeth may continue to discolour teeth despite best attempts to remove them. This study stresses the importance of material selection and minimising contact of Ledermix within the coronal aspects of teeth.

  13. Development of Orodispersible Tablets of Candesartan Cilexetil-β-cyclodextrin Complex

    Directory of Open Access Journals (Sweden)

    Maddukuri Sravya

    2013-01-01

    Full Text Available The aim of this study was to investigate the use of inclusion complexation technique employing β-cyclodextrin in improving the dissolution profile of candesartan cilexetil, a BCS class-II drug, and to formulate the inclusion complex into orodispersible tablets. The inclusion complexes were formed by physical mixing, kneading, coevaporation, and lyophilisation methods. Inclusion complexes were characterized by FTIR, DSC, XRD, NMR, and mass spectral studies. Inclusion complexes prepared using kneading, and lyophilisation techniques in the molar ratio 1 : 5 with β-cyclodextrin were used for formulating orodispersible tablets by direct compression with different superdisintegrants like croscarmellose sodium, crospovidone, sodium starch glycolate, and low substituted hydroxypropyl cellulose in varying concentrations. The directly compressible powder was evaluated for precompression parameters, and the prepared orodispersible tablets were evaluated for postcompression parameters. Drug-excipient compatibility studies showed no interaction, and characterization proved the formation of inclusion complex. In vitro disintegration time was found to be within 3 minutes, and all the formulations showed complete drug release of 100% within 20 minutes. The optimized formulation was found to be stable after 6 months and showed no significant change in drug content. This work proved β-cyclodextrins to be effective solubilizing agent in improving the solubility of poorly water soluble drugs.

  14. [Study on carving workers of Chong xiu zheng he jing shi zheng lei bei yong ben cao (Revised Prepared Materia Medica Classified under Syndromes in Zhenghe Period) published by Huiming Xuan (Huiming Sanctum)].

    Science.gov (United States)

    Liang, Fei; Li, Jian; Zhang, Wei; Zhang, Rui-Xian

    2012-11-01

    The ancient carving workers have made a great contribution to the xylographic printing art in ancient China, so the studies on them are significant for a survey of ancient Chinese printing history, and for the identification of ancient Chinese books edition. Zheng lei ben cao published by Huiming Xuan (Huiming Sanctum) in the Jin and Yuan dynasties, which is the earliest extant edition of Zhenghe version system of Zheng lei ben cao and has important literature value. Thirty carving workers were involved in its printing process. On the whole, these workers had a relatively high technique and completed a remarkably fine work. In addition to lettering, 28 persons of them also made a total of 536 pages with 900 exquisite engraving illustrations on Chinese materia medica included in this book. Because of the high levels on carving, this precious book has been the representative of Pingshui edition, which has a great reputation but has very few works now.

  15. [Study on carving workers of Chong xiu zheng he jing shi zheng lei bei yong ben cao (Revised Prepared Materia Medica Classified under Syndromes in Zhenghe Period) published by Huiming Xuan (Huiming Sanctum)].

    Science.gov (United States)

    Liang, Fei; Li, Jian; Zhang, Wei; Zhang, Rui-Xian

    2012-11-01

    The ancient carving workers have made a great contribution to the xylographic printing art in ancient China, so the studies on them are significant for a survey of ancient Chinese printing history, and for the identification of ancient Chinese books edition. Zheng lei ben cao published by Huiming Xuan (Huiming Sanctum) in the Jin and Yuan dynasties, which is the earliest extant edition of Zhenghe version system of Zheng lei ben cao and has important literature value. Thirty carving workers were involved in its printing process. On the whole, these workers had a relatively high technique and completed a remarkably fine work. In addition to lettering, 28 persons of them also made a total of 536 pages with 900 exquisite engraving illustrations on Chinese materia medica included in this book. Because of the high levels on carving, this precious book has been the representative of Pingshui edition, which has a great reputation but has very few works now. PMID:23363847

  16. Management of patients with uncontrolled arterial hypertension – the role of electronic compliance monitoring, 24-h ambulatory blood pressure monitoring and Candesartan/HCT

    Directory of Open Access Journals (Sweden)

    Tousset Eric

    2006-08-01

    Full Text Available Abstract Background Incomplete drug regimen compliance (DRC and white-coat hypertension are two of several possible causes of uncontrolled hypertension. Therefore the aim of the present study was to compare DRC in hypertensives treated with combination therapy whose blood pressures (BP were controlled vers. uncontrolled after 4 weeks of self-monitored BP measurement. To observe the consequences in uncontrolled patients of switching one drug of the combination therapy to candesartan/HCTZ (16 mg/12.5 mg with and without a compliance intervention program. Methods Self-and ambulatory-monitoring of BP were done with upper arm oscillometric devices. Patients' dosing histories were compiled electronically (MEMS(c, AARDEX. Patients with office blood pressure (OBP >140/90 mmHg despite combination therapy were begun on MEMS monitoring and self BP measurement for 4 weeks of run-in. Of 62 such patients, 18 (29% patients were normotensive according to self BP measurement and ambulatory BP measurement at 4 weeks (Group A; in the remaining 44 still uncontrolled patients, candesartan/HCTZ was substituted for one of the combination therapy drugs, with half these patients receiving passive compliance monitoring (B and half a DRC intervention program (C. All groups were then followed for 8 weeks. Results DRC before week 4 was significantly higher in A than in the uncontrolled patients (B&C. DRC was stable during run-in A, but declined in B and C. DRC after week 4 was not different in the three groups and stayed constant over time. DRC during weekends was lower than during weekdays in all groups. In group A no significant change in blood pressure was observed with all three methods of BP measurements. In groups B and C significant reductions of systolic and diastolic BP were observed for ABPM and SBPM. After the change to candesartan/HCTZ in B&C ambulatory 24-h-BP (ABPM was normalized in 39% of patients. Conclusion Normalization of BP was associated with superior

  17. Padronização dos critérios de seleção em estudos sobre medicações nasais Standardizing selection criteria in nasal medication studies

    Directory of Open Access Journals (Sweden)

    Andrei Borin

    2009-12-01

    Full Text Available Estudos clínicos sobre medicações tópicas nasais exigem a padronização de "normalidade nasossinusal" na constituição de grupos controle através de uma avaliação específica da via aérea superior. OBJETIVO: Padronizar a avaliação de candidatos a grupos controle em estudos clínicos sobre medicações tópicas nasais. MATERIAL E MÉTODO: Voluntários do sexo masculino, de 18 a 50 anos, que se declararam saudáveis, livres de doenças e assintomáticos nasossinusais foram submetidos a uma avaliação sequencial e excludente composta de uma avaliação clínica, teste cutâneo de hipersensibilidade imediata, teste da sacarina, nasofibroscopia flexível e citograma nasal. DESENHO DO ESTUDO: Coorte contemporânea com corte transversal. RESULTADOS: Dos 33 indivíduos inicialmente incluídos, 14 (42,4% foram excluídos na avaliação clínica. Dos 19 restantes, 2 (10,5% apresentaram atopia no teste cutâneo, sendo excluídos. 17 foram submetidos ao teste da sacarina demonstrando em todos os casos uma depuração mucociliar normal, sendo avaliados por nasofibroscopia flexível que detectou anormalidade em 2 casos (11,8% e excluídos. Os 15 restantes foram submetidos ao citograma nasal, demonstrando normalidade, representando 45,5% dos indivíduos inicialmente incluídos. CONCLUSÃO: O protocolo proposto de avaliação sequencial e excludente foi efetivo na definição de candidatos à constituição de grupos controle em estudos clínicos sobre medicações tópicas nasais.Clinical studies on nasal topical medications require the standardization of "nasosinusal normality" in order to establish control groups through a specific evaluation of the upper airways. AIM: to standardize the evaluation of candidates for control groups in clinical studies on nasal topical medications. MATERIAL AND METHODS: healthy male volunteers of 18 to 50 years of age, asymptomatic from the nasosinusal standpoint were subjected to a sequential and excluding

  18. Chemical Composition and in Vitro Antimicrobial, Cytotoxic, and Central Nervous System Activities of the Essential Oils of Citrus medica L. cv. 'Liscia' and C. medica cv. 'Rugosa' Cultivated in Southern Italy.

    Science.gov (United States)

    Aliberti, Luigi; Caputo, Lucia; De Feo, Vincenzo; De Martino, Laura; Nazzaro, Filomena; Souza, Lucéia Fátima

    2016-01-01

    Citrus medica cv. 'liscia' and C. medica cv. 'rugosa' are two taxa of citron, belonging to the biodiversity of South Italy, in particular of Amalfi Coast, in the Campania region. The chemical composition of the essential oils (EOs) from fruit peels of both C. medica cultivars was studied by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) analyses. In all, 100 compounds were identified, 82 for C. medica cv. 'liscia', accounting for 91.4% of the total oil, and 88 for C. medica cv. 'rugosa', accounting for 92.0% of the total oil. Monoterpene hydrocarbons are the main constituents in both oils of C. medica cv. 'liscia' (79.1%) and C. medica cv. 'rugosa' (80.2%). In both oils, limonene (67.2%-62.8%) and camphene (8.5%-10.9%) are the main constituents. The antimicrobial activity of the EOs was assayed against some bacterial strains: Bacillus cereus (DSM 4313), Bacillus cereus (DSM 4384), Staphylococcus aureus (DSM 25693), Pseudomonas aeruginosa (ATCC 50071), and Escherichia coli (DSM 8579). Low concentrations of C. medica cv. 'rugosa' EO showed an inhibitory effect on P. aeruginosa and higher concentrations inhibited more B. cereus (4384) and E. coli than S. aureus. The cytotoxicity of the EO was evaluated against SH-SY5Y cell line. The influence of the EO on the expression of adenylate cyclase 1 (ADCY1) was also studied. The antimicrobial activity registered confirm their traditional uses as food preserving agents and led us to hypothesize the possible use of these oils as antimicrobials. The alterations in ADCY1 expression suggested a role for limonene in effects on the central nervous system. PMID:27649138

  19. Introducing candesartan 32 mg plus hydrochlorothiazide 25 mg in previously untreated patients with severe essential hypertension

    OpenAIRE

    Kiel,

    2011-01-01

    Peter Baumgart1, Ingomar Naudts2, Gerhard Kiel31Clemenshospital Muenster, Academic Teaching Hospital of University of Muenster, Germany; 2General Practitioner, group practice, Ludwig-Erhard-Platz 9, Rodgau, Germany; 3Medical Department and Clinical Research, Takeda Pharma GmbH, Aachen, GermanyPurpose: To investigate the efficacy of candesartan 32 mg and hydrochlorothiazide (HCTZ) 25 mg combination in patients with severe essential hypertension.Patients and methods: In this prospective, open-l...

  20. [Marihuana and cannobinoids as medicaments].

    Science.gov (United States)

    Tkaczyk, Marek; Florek, Ewa; Piekoszewski, Wojciech

    2012-01-01

    Biological activity of cannabinoids is caused by binding to two cannabinoid receptors CB1 and CB2. Psychoactive is not only tetrahydrocannabinol (THC) but also: cannabidiol, cannabigerol or cannabichromen. Formerly, the usefulness of hemp was assessed in the relation to temporary appeasement of the symptoms of some ailments as nausea or vomiting. Present discoveries indicates that cannabis-based drugs has shown ability to alleviate of autoimmunological disorders such as: Multiple sclerosis (MS), Rheumatoid arthritis (RA) or inflammatory bowel disease. Another studies indicates that cannabinoids play role in treatment of neurological disorders like Alzheimer disease or Amyotrophic lateral sclerosis (ALS) or even can reduce spreading of tumor cells. Cannabinoids stand out high safety profile considering acute toxicity, it is low possibility of deadly overdosing and side-effects are comprise in range of tolerated side-effects of other medications. In some countries marinol and nabilone are used as anti vomiting and nausea drug. First cannabis-based drug containg naturally occurring cannabinoids is Sativex. Sativex is delivered in an mucosal spray for patients suffering from spasticity in MS, pain relevant with cancer and neuropathic pain of various origin. Despite the relatively low acute toxicity of cannabinoids they should be avoid in patients with psychotic disorders, pregnant or breastfeeding woman. Cannabinoids prolong a time of reaction and decrease power of concentration that's why driving any vehicles is forbidden. Cannabis side-effects varies and depend from several factors like administrated dose, rout of administration and present state of mind. After sudden break from long-lasting use, withdrawal symptoms can appear, although they entirely disappear after a week or two.

  1. [Marihuana and cannobinoids as medicaments].

    Science.gov (United States)

    Tkaczyk, Marek; Florek, Ewa; Piekoszewski, Wojciech

    2012-01-01

    Biological activity of cannabinoids is caused by binding to two cannabinoid receptors CB1 and CB2. Psychoactive is not only tetrahydrocannabinol (THC) but also: cannabidiol, cannabigerol or cannabichromen. Formerly, the usefulness of hemp was assessed in the relation to temporary appeasement of the symptoms of some ailments as nausea or vomiting. Present discoveries indicates that cannabis-based drugs has shown ability to alleviate of autoimmunological disorders such as: Multiple sclerosis (MS), Rheumatoid arthritis (RA) or inflammatory bowel disease. Another studies indicates that cannabinoids play role in treatment of neurological disorders like Alzheimer disease or Amyotrophic lateral sclerosis (ALS) or even can reduce spreading of tumor cells. Cannabinoids stand out high safety profile considering acute toxicity, it is low possibility of deadly overdosing and side-effects are comprise in range of tolerated side-effects of other medications. In some countries marinol and nabilone are used as anti vomiting and nausea drug. First cannabis-based drug containg naturally occurring cannabinoids is Sativex. Sativex is delivered in an mucosal spray for patients suffering from spasticity in MS, pain relevant with cancer and neuropathic pain of various origin. Despite the relatively low acute toxicity of cannabinoids they should be avoid in patients with psychotic disorders, pregnant or breastfeeding woman. Cannabinoids prolong a time of reaction and decrease power of concentration that's why driving any vehicles is forbidden. Cannabis side-effects varies and depend from several factors like administrated dose, rout of administration and present state of mind. After sudden break from long-lasting use, withdrawal symptoms can appear, although they entirely disappear after a week or two. PMID:23421098

  2. [Management of Chinese materia medica market based on information asymmetry].

    Science.gov (United States)

    Yang, Guang; Wang, Nuo; Guo, Lan-Ping; Wang, Yong-Yan; Huang, Lu-Qi; Liu, Jin-Xin

    2013-12-01

    Pharmaceutical market is a typical market with information asymmetry, and which can lead to "lemons" problem. In all developed countries, firms must receive regulatory approval to market a pharmaceutical product. Such administrative department including SFDA, EMA, FDA and so on. Chinese materia medica is a special part of pharmaceutical market in China. The management of Chinese materia medica is a special challenge in China.

  3. Mixed solvency concept in reducing surfactant concentration of self-emulsifying drug delivery systems of candesartan cilexetil using D-optimal mixture design

    Directory of Open Access Journals (Sweden)

    Chandna Chandan

    2013-01-01

    Full Text Available The objective of this present study was to explore the utility of "mixed solvency" concept to enhance the solubility of poorly-water soluble drug, candesartan cilexetil (CC in modified solubilizer system. The objective of this paper is to reduce the surfactant concentration traditionally involved in the formulation of self-emulsifying drug delivery systems (SEDDS by proposing an alternate system of solubilizer to provide novel surfactant/cosurfactant system, to aid traditionally involved components in the formulation of SEDDS. The present study showed that "mixed solvency" concept was successfully employed in solubility enhancement of CC in (Transcutol P: B 3 Mix [1:1] up to 303 mg/g of blend. Present study demonstrated the promising use of "mixed solvency" concept in solubility enhancement of poorly-water soluble drugs and tool to reduce the net surfactant concentration employed in designing of SEDDS.

  4. Effect of candesartan on microalbuminuria and albumin excretion rate in diabetes: three randomized trials

    DEFF Research Database (Denmark)

    Bilous, Rudy; Chaturvedi, Nish; Sjølie, Anne Katrin;

    2009-01-01

    , caregivers, and researchers were blinded to treatment assignment. During a median follow-up of 4.7 years, 793 patients discontinued therapy and 63 were lost to follow-up. MEASUREMENTS: Urinary albumin excretion rate, assessed annually by 2 overnight collections; if it was 20 microg/min or greater, then 2...... further collections were done. The primary end point was new microalbuminuria (3 or 4 collections of urinary albumin excretion rate >or=20 microg/min). The secondary end point was rate of change in albuminuria. RESULTS: Individual and pooled results of the 3 trials showed that candesartan had little...

  5. Progress of Experimental Study on Treatment of Psoriasis by Chinese Medicinal Monomer and Single or Compound Recipe in Chinese Materia Medica

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Psoriasis is a common,chronic,recurrent inflammatory skin disorder whose etiology is still unknown.It is believed that a multiple-gene inheritance is involved and it also involves various factors such as immunity,inflammation,cell proliferation,apoptosis,neural media,etc.Since cytokines are key mediators in inflammation,a number of Chinese medicines(CMs)have been reported to have certain antagonist effects on pro-inflammatory cytokines such as tumor necrosis factor-a(TNF-α),platelet active factor(PAF)and interleukin-8(IL-8).Some researches on CMs have made significant breakthroughs in psoriasis by intervening with cytokines.Abnormalities with keratinocyte proliferation and apoptosis are considered to be present in patients with psoriasis and a number of studies show that the mechanism of CMs on psoriasis may be through the inhibition of the keratinocyte proliferation and induction of apoptosis.Other studies also show that the inhibition of fibroblast-secreted cytokines could regulate keratinocyte proliferation and differentiation and reduce the level of Calcitonin gene-related peptide(CGRP)in plasma and in lesions so as to slow down the process of inflammation and proliferation in psoriasis.The most commonly used models for psoriasis are the scaled tails or the vaginal epithelium of mice in China.They were used to observe the histopathological changes after the model mice were treated with CMs with the inhibition on the mitosis of vaginal epithelium or promotion of granular layer in rat tail taken as the indices of clinical efficacy.A variety of signs occur in psoriasis patients with TCM blood-stasis syndrome type and the effect of CMs in activating blood circulation to remove blood stasis on psoriasis suggested that the mechanism of CMs may be partially correlated to hemorrheology and microcirculation.Along with the continuous development of the biosciences,some TCM theories for psoriasis have been confirmed by laboratory studies.However,the exploration into

  6. High-density lipoprotein cholesterol strongly discriminates between healthy free-living and disabled octo-nonagenarians: a cross sectional study. Associazione Medica Sabin.

    Science.gov (United States)

    Zuliani, G; Palmieri, E; Volpato, S; Bader, G; Mezzetti, A; Costantini, F; Sforza, G R; Imbastaro, T; Romagnoni, F; Fellin, R

    1997-10-01

    Aging is frequently associated with a deterioration in health and functional status, which often induces important modifications in several biological parameters, including plasma lipids; as a consequence, the real "meaning" of lipoprotein parameters in old individuals is complex. A cross sectional study was carried out in order to investigate the lipoprotein profile in very old individuals with or without disability, and evaluate the possible influence of other biological variables on plasma lipids. One hundred selected healthy free-living (FL) and 62 disabled (DIS) subjects aged over 80 were enrolled; 91 healthy adults matched for origin were included as controls. Lipoprotein profile [total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, apoprotein A-I and B], anthropometric parameters, and ADL were measured. The FL octo-nonagenarians featured higher HDL-cholesterol levels than adult controls. DIS octo-nonagenarians showed lower total and HDL-C levels than FL. Discriminant analysis indicated that HDL-cholesterol and apoprotein A-I, but not total cholesterol, strongly discriminated between FL and DIS octo-nonagenarians. Multivariate analysis demonstrated that the waist/hip ratio, an index of visceral adiposity, was negatively associated with HDL-C levels in FL, but not in DIS elderly. We conclude that: 1) in very old individuals, the absence or presence of disability is strongly associated with high or low HDL-cholesterol values, respectively; 2) HDL-C and apo A-I are the parameters which better discriminate between FL and DIS octo-nonagenarians; and 3) the differences in HDL-C levels between FL and DIS are not due to modifications in anthropometric parameters. Prospective studies are needed to better understand the relationship between high-density lipoprotein levels, disability and aging. PMID:9458994

  7. Angiotensin receptor blockade in acute stroke. The Scandinavian Candesartan Acute Stroke Trial: rationale, methods and design of a multicentre, randomised- and placebo-controlled clinical trial (NCT00120003)

    DEFF Research Database (Denmark)

    Sandset, Else Charlotte; Murray, Gordon; Boysen, Gudrun Margrethe;

    2010-01-01

    Elevated blood pressure following acute stroke is common, and yet early antihypertensive treatment is controversial. ACCESS suggested a beneficial effect of the angiotensin receptor blocker candesartan in the acute phase of stroke, but these findings need to be confirmed in new, large trials. AIM...... variables: Secondary effect variables include • the Barthel index (functional status) • EuroQol (quality of life) and • Mini-mental state examination (cognition) at 6-months • Health economic costs during the first 6-months......, Sweden, Denmark, Belgium, Germany, Poland, Lithuania, Estonia and Finland. STUDY OUTCOMES: There are two co-primary effect variables: • Functional status at 6-months, measured by the modified Rankin Scale, and • vascular death, myocardial infarction or stroke during the first 6-months. Secondary outcome...

  8. Office and ambulatory blood pressure control with a fixed-dose combination of candesartan and hydrochlorothiazide in previously uncontrolled hypertensive patients: results of CHILI CU Soon

    Directory of Open Access Journals (Sweden)

    Bramlage P

    2011-12-01

    Full Text Available Thomas Mengden1, Reinhold Hübner2, Peter Bramlage31Kerckhoff-Klinik GmbH, Bad Nauheim, 2Takeda Pharma GmbH, Aachen, 3Institut für Kardiovaskuläre Pharmakologie und Epidemiologie, Mahlow, GermanyBackground: Fixed-dose combinations of candesartan 32 mg and hydrochlorothiazide (HCTZ have been shown to be effective in clinical trials. Upon market entry we conducted a noninterventional study to document the safety and effectiveness of this fixed-dose combination in an unselected population in primary care and to compare blood pressure (BP values obtained during office measurement (OBPM with ambulatory blood pressure measurement (ABPM.Methods: CHILI CU Soon was a prospective, noninterventional, noncontrolled, open-label, multicenter study with a follow-up of at least 10 weeks. High-risk patients aged ≥18 years with previously uncontrolled hypertension were started on candesartan 32 mg in a fixed-dose combination with either 12.5 mg or 25 mg HCTZ. OBPM and ABPM reduction and adverse events were documented.Results: A total of 4131 patients (52.8% male with a mean age of 63.0 ± 11.0 years were included. BP was 162.1 ± 14.8/94.7 ± 9.2 mmHg during office visits at baseline. After 10 weeks of candesartan 32 mg/12.5 mg or 25 mg HCTZ, mean BP had lowered to 131.7 ± 10.5/80.0 ± 6.6 mmHg (P < 0.0001 for both comparisons. BP reduction was comparable irrespective of prior or concomitant medication. In patients for whom physicians regarded an ABPM to be necessary (because of suspected noncontrol over 24 hours, ABP at baseline was 158.2/93.7 mmHg during the day and 141.8/85.2 mmHg during the night. At the last visit, BP had significantly reduced to 133.6/80.0 mmHg and 121.0/72.3 mmHg, respectively, resulting in 20.8% being normotensive over 24 hours (<130/80 mmHg. The correlation between OBPM and ABPM was good (r = 0.589 for systolic BP and r = 0.389 for diastolic BP during the day. Of those who were normotensive upon OBPM, 35.1% had high ABPM during the

  9. Beneficial effects on arterial stiffness and pulse-wave reflection of combined enalapril and candesartan in chronic kidney disease--a randomized trial.

    Directory of Open Access Journals (Sweden)

    Marie Frimodt-Møller

    Full Text Available BACKGROUND: Cardiovascular disease (CVD is highly prevalent in patients with chronic kidney disease (CKD. Inhibition of the renin-angiotensinsystem (RAS in hypertension causes differential effects on central and brachial blood pressure (BP, which has been translated into improved outcome. The objective was to examine if a more complete inhibition of RAS by combining an angiotensin converting enzyme inhibitor (ACEI and an angiotensin receptor antagonist (ARB compared to monotherapy has an additive effect on central BP and pulse-wave velocity (PWV, which are known markers of CVD. METHODS: Sixty-seven CKD patients (mean GFR 30, range 13-59 ml/min/1.73 m(2 participated in an open randomized study of 16 weeks of monotherapy with either enalapril or candesartan followed by 8 weeks of dual blockade aiming at a total dose of 16 mg candesartan and 20 mg enalapril o.d. Pulse-wave measurements were performed at week 0, 8, 16 and 24 by the SphygmoCor device. RESULTS: Significant additive BP independent reductions were found after dual blockade in aortic PWV (-0.3 m/s, P<0.05 and in augmentation index (-2%, P<0.01 compared to monotherapy. Furthermore pulse pressure amplification was improved (P<0.05 and central systolic BP reduced (-6 mmHg, P<0.01. CONCLUSIONS: Dual blockade of the RAS resulted in an additive BP independent reduction in pulse-wave reflection and arterial stiffness compared to monotherapy in CKD patients. TRIAL REGISTRATION: Clinical trial.gov NCT00235287.

  10. The absence of protective effect of candesartan and angiotensin IV in the moderate brain injury in rats

    International Nuclear Information System (INIS)

    Background: angiotensin receptor blockers (ARB) are protective in various models of experimental ischemic stroke. This protective effect is mediated by the stimulation of non-AT1 receptors by angiotensin II and angiotensin IV. Since traumatic brain injury shares with ischemic cerebral injury several common mechanisms, we examined if a pretreatment with the ARB candesartan, or a post-treatment with angiotensin IV are also protective in a rat model of blunt traumatic brain injury (TBI). Methods :adults Sprague Dawley rats were treated for five days with candesartan (0.5 mg/kg/day) or saline by gavage prior to the induction of diffuse moderate TBI using the impact-acceleration model. Two others groups of rats were treated by a daily intraperitoneal injection of angiotensin IV (1.5 mg/kg/day) or saline for five days following TBI. Overall neurological insult were assessed daily by measuring the neurological score. Sensitive deficits (scotch test) and sensorimotor deficits (beam-walking test) were evaluated daily from day 1 to 7 and at day 15; cognitive impairment (object recognition test) was evaluated at day 15. Results : TBI induced significant sensitive and sensorimotor deficits that were maximal at day 1 and spontaneously improved with time. At day 15, traumatised animals had a marked alteration of the working memory. Neither treatment with candesartan, angiotensin IV or with erythropoietin decreased the severity of the initial sensorimotor deficits, nor accelerate the recovery rate. Candesartan, angiotensin IV had likewise no protective effect on the cognitive deficit evaluated to day 15. Conclusion: pretreatment with candesartan and post-treatment with angiotensin IV are both ineffective to protect against sensorimotor and c ognitive impairment in a rat model of impact-acceleration TBI. (author)

  11. Comparative Clinical- and Cost-Effectiveness of Candesartan and Losartan in the Management of Hypertension and Heart Failure: A Systematic Review, Meta- and Cost-Utility Analysis

    OpenAIRE

    Grosso, Anthony; Bodalia, Pritesh; Macallister, Raymond; Hingorani, Aroon; Moon, James; Scott, Michael

    2011-01-01

    Abstract Background The UK currently spends in excess of #250 million per annum on angiotensin-II receptor blockers; with candesartan currently dominating the market. With the recent introduction of generic losartan, we set out to directly compare the branded market leader to its now cheaper alternative. Objectives The primary objectives were to compare the blood pressure (BP) lowering efficacy and cardiovascular outcomes of candesartan and losartan in the treatment of essentia...

  12. Yeast α-Glucosidase Inhibitory Phenolic Compounds Isolated from Gynura medica Leaf

    Directory of Open Access Journals (Sweden)

    Chao Tan

    2013-01-01

    Full Text Available Gynura medica leaf extract contains significant amounts of flavonols and phenolic acids and exhibits powerful hypoglycemic activity against diabetic rats in vivo. However, the hypoglycemic active constituents that exist in the plant have not been fully elaborated. The purpose of this study is to isolate and elaborate the hypoglycemic activity compounds against inhibition the yeast α-glucosidase in vitro. Seven phenolic compounds including five flavonols and two phenolic acids were isolated from the leaf of G. medica. Their structures were identified by the extensive NMR and mass spectral analyses as: kaempferol (1, quercetin (2, kaempferol-3-O-β-D-glucopyranoside (3, kaempferol-3-O-rutinoside (4, rutin (5, chlorogenic acid (6 and 3,5-dicaffeoylquinic acid methyl ester (7. All of the compounds except 1 and 3 were isolated for the first time from G. medica. Compounds 1–7 were also assayed for their hypoglycemic activity against yeast α-glucosidase in vitro. All of the compounds except 1 and 6 showed good yeast α-glucosidase inhibitory activity with the IC50 values of 1.67 mg/mL, 1.46 mg/mL, 0.38 mg/mL, 0.10 mg/mL and 0.53 mg/mL, respectively.

  13. 以专业为先导在《中药学》教学中实施多元化考核方式的探讨%Study on Diversified Evaluation Mode of Chinese Materia Medica in Different Specialities

    Institute of Scientific and Technical Information of China (English)

    刘立萍; 任艳玲; 李然

    2013-01-01

    To promote the innovate of diversified examining mode of Chinese Materia Medica education,this article summarizes the reform of exam mode in School of Chinese medicine and Pharmacy and then describes the implementation process and significance in the usage of the exam pattern of diversity in different specialties.It will provide a meaningful reference for the reform of education.%该文梳理了国内各中医药院校考核方式改革的概况和发展趋势,介绍了多元化考核方式在中医学专业和中药学专业《中药学》教学过程中的具体实施方法和意义,旨在为《中药学》考核方式改革提供借鉴.

  14. Effects of Chinese materia medica combined chemotherapy on the survivals of stage Ⅱ and Ⅲ colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    吕仙梅

    2012-01-01

    Objective To study the effects of Chinese materia medica (CMM) combined chemotherapy on the recurrence,metastasis,and the disease free survival(DFS) of stage Ⅱ and Ⅲ colorectal cancer (CC) patients after radical treatment. Methods 366 inpatients and outpatients with stage Ⅱ and Ⅲ colorectal

  15. Study on the Determination Method of Oxytetracycline Added Illegally in Veterinary Chinese Materia Medica Powders by HPLC%HPLC法测定中兽药散剂中非法添加土霉素的方法研究

    Institute of Scientific and Technical Information of China (English)

    李树纲; 金录胜; 王登临; 杲寿善; 张宏; 于清伟; 张蕾; 史梓萱

    2011-01-01

    建立了高效液相色谱法检测清肺散、白头翁散、止痢散等中兽药散剂中非法添加土霉素的方法。用十八烷基硅烷键合硅胶色谱柱,以0.05 mol/L草酸铵溶液-二甲基甲酰胺-0.2 mol/L磷酸氢二铵(75∶20∶5)(用氨试液调pH值至8.0±0.2)为流动相,检测波长280 nm,流速1.0mL/min,进样量20μL,柱温35℃。结果显示,土霉素的线性范围为100~300μg/mL,线性方程为Y=4.90×10 X-2.39×103(,r=0.999 6,n=5),本方法的回收率为80.68%~119.23%,RSD为0.66%~1.85%。结果表明,本方法准确、可靠,适用于中兽药散剂中非法添加土霉素的检测。%An HPLC method was established for effective detection on oxytetracycline added illegally in veterinary Chinese materia medica powders as Qingfei San,Baitouweng San and Zhili San,etc.A reverse-phase C18 column was used,the mobile phase was 0.05 mol/L ammonium oxalate solution-DMF-0.2 mol/L ammonium dibasic phosphate(75∶ 20∶ 5)(adjusted the pH value with ammoniac solution to 8.0±0.2),the determination wave length was 280 nm,the flow rate was 1.0 mL/min and the column worked at 35 ℃.The result demonstrated that the linearity range of oxytetracycline was 100~300 μg/mL,the linear equation is Y=4.90×10 X-2.39×103(r=0.999 6,n=5),the recovery was 80.68%~119.23%,RSD was 0.66%~1.85%.It indicated that this method was accurate,reliable,and suitable in the determination of oxytetracycline added illegally in veterinary Chinese materia medica powders.

  16. Alfalfa microsymbionts from different ITS and nodC lineages of Ensifer meliloti and Ensifer medicae symbiovar meliloti establish efficient symbiosis with alfalfa in Spanish acid soils.

    Science.gov (United States)

    Ramírez-Bahena, Martha-Helena; Vargas, Margarita; Martín, María; Tejedor, Carmen; Velázquez, Encarna; Peix, Álvaro

    2015-06-01

    Alfalfa (Medicago sativa L.) is an important crop worldwide whose cropping in acid soils is hampered by the poor nodulation and yield commonly attributed to the sensitivity of its endosymbionts to acid pH. In this work, we isolated several acid-tolerant strains from alfalfa nodules in three acid soils in northwestern Spain. After grouping by RAPD fingerprinting, most strains were identified as Ensifer meliloti and only two strains as Ensifer medicae according to their 16S-23S intergenic spacer (ITS) sequences that allowed the differentiation of two groups within each one of these species. The two ITS groups of E. meliloti and the ITS group I of E. medicae have been previously found in Medicago nodules; however, the group II of E. medicae has been only found to date in Prosopis alba nodules. The analysis of the nodC gene showed that all strains isolated in this study belong to the symbiovar meliloti, grouping with the type strains of E. meliloti or E. medicae, but some harboured nodC gene alleles different from those found to date in alfalfa nodules. The strains of E. medicae belong to the symbiovar meliloti which should be also recognised in this species, although they harboured a nodC allele phylogenetically divergent to those from E. meliloti strains. Microcosm experiments showed that inoculation of alfalfa with selected acid-tolerant strains significantly increased yields in acid soils representing a suitable agricultural practice for alfalfa cropping in these soils. PMID:25586575

  17. [Preliminary investigation on the materia medica of the Zhuang ethnic group].

    Science.gov (United States)

    Rong, Xiao-Xiang; Li, Gui

    2013-09-01

    By Zhuang materia medica, it refers to application of medicines under the instructions of medical theory of Zhuang ethnic group. By studying the pronunciation of the Zhuang language for the terms "zhu yu", "bai jiu", and "mi gu" included in the shan hai jing nan shan jing (The Classic of Southern Mountain in Classic of Seas and Mountains) carried out by the Zhuang scholar Qin Bao-lin, it was concluded that the Zhuang minority already applied medicines early in the pre-Qin period. Through extensive cultural communication in different regions in the Wei-Jin-Southern-Northern Dynasties, the medicinal experiences of the Zhuang ethnic group appeared in ancient literature. The antidotes in Zhou hou fang (Handbook of Prescriptions for Emergency), for instance, were mostly coming from the Southern Ridge area. Since the Sui-Tang Dynasties, many materia medica recorded in the herbal works and regional gazetteers, and Annals such as the Guangxi Annals, Gazetteer of Nanning County, and Gazetteer of Liuzhou County, Gazetteer of Binzhou County etc., also carry medicines such as Cinnamom twigs and bark, and mangosteen etc., which are similar to those of the Zhuang medicines. In the Republican period, many manuscripts of Zhuang medicines appeared. After 1949, many institutions of Zhuang medicine were set up successively, including The Nanning Medical Institute, The Medical Institute of Wuzhou, The Medical Institute of Guilin. Systematic researches were also done, with publication of a series of works on Zhuang materia medica. Reformation of part of the prescription forms of Zhuang medicine were also accomplished.

  18. Review of the Journal Acta Informatica Medica During Eight Year Period: 2008-2015

    Science.gov (United States)

    Masic, Izet; Begic, Edin; Zunic, Lejla

    2016-01-01

    Introduction: Acta Informatica Medica is official journal of the Academy for Medical Sciences of Bosnia and Herzegovina (from 2014 Acta Inform Med is published bimonthly). Aim: To evaluate journal “Acta Informatica Medica” in 2015 and compare findings to previous years. Material and methods: The study has retrospective and descriptive character, and included the period 2008-2015 (included 36 issues of journal). Results: A total of 83 (average 13,8 articles per journal) articles were published in Acta Informatica Medica during 2015. Analyzing the type of articles, original articles are present in majority during 2015 (68,6%) (by analyzing last eight years, 310 (67,3%) were original). During 2015, 27,7% of articles were related to the applied of Health informatics in field of clinical medicine, 63,8% preclinical medicine and 8,5% to public health. Collaboration rate in 2015 was 0,84. Most often the time required for decision on acceptance of article in 2015 is between 50 and 60 days. Articles came from 16 countries. According to scimagojr.com for 2014, Acta Informatica Medica has SCImago Journal Rank 0,166, while Cites / Doc. (2 years) parameter (widely used as impact index) is 0,70. According to GoogleScholar, h5 index is 11 and h5 median is 19. We analyzed the Acta Informatica Medica by “Publish or Perish” software - H index was 14, g index was 19 and e-index was 10.39. Conclusion: Year after year the highest number of original articles are published. Although the period of revision of articles is acceptable, the period up to two months is certainly not long, the goal is to reduce this period. Although the magazine in mentioned field found its place, although it is indexed in numerous bases, including: PubMed, PubMed Central, SCOPUS, EMBASE, EBSCO, etc. The main goal for next year is that the magazine becomes part of the Web of Science. Imperative is further internationalization of the magazine. PMID:27147796

  19. [Research on Zhang's collated edition of Lei gong pao zhi lun (Master Lei's Discourse on Processing of Chinese Materia Medica)].

    Science.gov (United States)

    Cheng, Li

    2010-05-01

    Lei gong pao zhi lun (Master Lei's Discourse on Processing of Chinese Materia Medica) collated by Zhang Ji, and printed by Zhang's Yisheng Tang in Chengdu in 1932 was the first collated edition. Its original edition was not Jing shi zheng lei bei ji ben cao (Classified Materia Medica from Historical Classics for Emergency) of the Song Dynasty, but was Xiu shi zhi nan (Instruction for Drug Processing) and Lei gong pao zhi yao xing jie (Explanation on Master Lei's Properties of Drugs Processing) of the Qing Dynasty. The contents of this collated edition was far from Lei gong pao zhi lun with many mistakes, and was not the best edition to study Lei gong pao zhi lun. PMID:21029711

  20. Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial

    DEFF Research Database (Denmark)

    Sjolie, A.K.; Klein, R.; Porta, M.;

    2008-01-01

    BACKGROUND: Diabetic retinopathy remains a leading cause of visual loss in people of working age. We examined whether candesartan treatment could slow the progression and, secondly, induce regression of retinopathy in people with type 2 diabetes. METHODS: We did a randomised, double-blind, parall...

  1. Pectin extraction from Citron peel (Citrus medica Linn. and its use in food system

    Directory of Open Access Journals (Sweden)

    Rojanakorn, T.

    2006-11-01

    Full Text Available Screening experiments using 25-1 fractional factorial design showed that pH, temperature, and extracting time were the main factors affecting the amount and quality of extracted pectin from Citrus medica Linn. Optimum condition of pectin extraction was studied using central composite design (CCD. Mathematical models relating pH, temperature and extracted time to amount of extracted pectin, equivalent weight, methyl content and anhydrogalacturonic acid content were established. Based on the mathematics models, the condition of pH 2, 100ºC and 105 min was found to be the optimum conditions for pectin extraction from Citrus medica Linn. Mathematical and experimental results were verified. The use of extracted pectin as a gelling agent in pineapple jam revealed no significant difference in gel consistency compared to that of commercial pectin grade 150 (p>0.05. However, the commercial pectin had a higher liking score on the spreadability, texture and overall liking. As a stabilizer in chocolate pasteurised milk, 0.2% of the extracted pectin was required to prevent precipitation of chocolate powder with the similar viscosity obtained from 0.06% κ-carageenan

  2. Prevention of cardiac dysfunction during adjuvant breast cancer therapy (PRADA): a 2 × 2 factorial, randomized, placebo-controlled, double-blind clinical trial of candesartan and metoprolol

    Science.gov (United States)

    Gulati, Geeta; Heck, Siri Lagethon; Ree, Anne Hansen; Hoffmann, Pavel; Schulz-Menger, Jeanette; Fagerland, Morten W.; Gravdehaug, Berit; von Knobelsdorff-Brenkenhoff, Florian; Bratland, Åse; Storås, Tryggve H.; Hagve, Tor-Arne; Røsjø, Helge; Steine, Kjetil; Geisler, Jürgen; Omland, Torbjørn

    2016-01-01

    Aims Contemporary adjuvant treatment for early breast cancer is associated with improved survival but at the cost of increased risk of cardiotoxicity and cardiac dysfunction. We tested the hypothesis that concomitant therapy with the angiotensin receptor blocker candesartan or the β-blocker metoprolol will alleviate the decline in left ventricular ejection fraction (LVEF) associated with adjuvant, anthracycline-containing regimens with or without trastuzumab and radiation. Methods and results In a 2 × 2 factorial, randomized, placebo-controlled, double-blind trial, we assigned 130 adult women with early breast cancer and no serious co-morbidity to the angiotensin receptor blocker candesartan cilexetil, the β-blocker metoprolol succinate, or matching placebos in parallel with adjuvant anticancer therapy. The primary outcome measure was change in LVEF by cardiac magnetic resonance imaging. A priori, a change of 5 percentage points was considered clinically important. There was no interaction between candesartan and metoprolol treatments (P = 0.530). The overall decline in LVEF was 2.6 (95% CI 1.5, 3.8) percentage points in the placebo group and 0.8 (95% CI −0.4, 1.9) in the candesartan group in the intention-to-treat analysis (P-value for between-group difference: 0.026). No effect of metoprolol on the overall decline in LVEF was observed. Conclusion In patients treated for early breast cancer with adjuvant anthracycline-containing regimens with or without trastuzumab and radiation, concomitant treatment with candesartan provides protection against early decline in global left ventricular function. PMID:26903532

  3. 坎地沙坦酯与培哚普利联合治疗对高血压患者尿微量白蛋白影响的临床观察%Clinical observation on candesartan cilexetil and perindopril combined treatment on microalbuminuria for patients with hypertension

    Institute of Scientific and Technical Information of China (English)

    杨蕾; 楚英杰; 张培荣; 王宇航; 刘晓宇; 李兵; 赵香梅; 董淑娟; 贺文奇; 许文克

    2014-01-01

    Objective To evaluate the clinical effect of candesartan cilexetil and perindopril on urinary microalbumin in hypertension patients.MethodsThere were 150 patients with hypertension included in the study, 50 cases for each group: candesartan cilexetil 8 mg/d (groupCA), perindopril 4 mg/d (group PE), candesartan cilexetil 8 mg/d combined with perindopril 4 mg/d (CP group), blood pressure, urinary albumin were analyzed. ResultsGroup CP , group CA, group PE, the total effective rate was 90%, 74%, 72%.The CP group was better than group CA, group PE , there were statistically significant (P<0.05); three groups could reduce urinary albumin content; group CP reduced the urinary albumin significantly, which was better than that of group CA and group PE, there were statistically significant (P<0.05).ConclusionCandesartan cilexetil combined with perindopril can treat microalbuminuria for patients with hypertension effectively.%目的:评价坎地沙坦酯联合培哚普利治疗高血压患者尿微量白蛋白的临床疗效。方法高血压患者150例临床资料进行分析,分别使用坎地沙坦酯8 mg/d(CA组)、培哚普利4 mg/d(PE组)、坎地沙坦酯8 mg/d联合培哚普利4 mg/d(CP组),测定治疗前后的血压、尿微量白蛋白值。结果CP组、CA组、PE组的总有效率分别为90.00%、74.00%、72.00%, CP组疗效优于CA组和PE组,差异具有统计学意义(P<0.05);三组方案都可以降低尿微量白蛋白含量, CP组能显著减低尿微量白蛋白含量,优于CA组及PE组,差异均具有统计学意义(P<0.05)。结论坎地沙坦酯与培哚普利联合治疗高血压患者尿微量白蛋白具有良好效果。

  4. Anàlisi de la utilització de medicaments en població pediàtrica i adulta utilització de medicaments en condicions no aprovades /

    OpenAIRE

    Danés Carreras, Immaculada; Vallano Ferraz, Antonio

    2015-01-01

    Els estudis d'utilització de medicaments permeten identificar els patrons d'ús dels medicaments en diferents poblacions, ja siguin adults o nens. Un aspecte és l'anàlisi de l'ús de medicaments en condicions diferents a les autoritzades a la fitxa tècnica. Aquesta tesi és una anàlisi de diferents aspectes de l'ús de medicaments en condicions no aprovades després que es publiqués el Reial Decret 1015/2009 del 19 de juny pel qual es regula la disponibilitat de medicaments en diferents situacions...

  5. Anàlisi de la utilització de medicaments en població pediàtrica i adulta. utilització de medicaments en condicions no aprovades

    OpenAIRE

    Danés Carreras, Immaculada

    2015-01-01

    Els estudis d'utilització de medicaments permeten identificar els patrons d'ús dels medicaments en diferents poblacions, ja siguin adults o nens. Un aspecte és l’anàlisi de l’ús de medicaments en condicions diferents a les autoritzades a la fitxa tècnica. Aquesta tesi és una anàlisi de diferents aspectes de l’ús de medicaments en condicions no aprovades després que es publiqués el Reial Decret 1015/2009 del 19 de juny pel qual es regula la disponibilitat de medicaments en diferents situacions...

  6. LaMedica - Eine multimediale online Lehr- und Lernplattform [

    Directory of Open Access Journals (Sweden)

    Stracke, Sylvia

    2006-02-01

    Full Text Available [english] The project LaMedica ( has as its aim the development of a multimedia teaching and learning platform, the compilation of contents for medicine and the implementation of these in the teaching process. An on-line author environment was created which supports a variety of didactic approaches: systematic and networked communication of knowledge, case-based learning, the creation of lectures and learning sequence checks. The teaching contents can be edited and illustrated, and are aimed in particular at students, doctors in continuing education and specialists. An on-line media databank supports the re-use and the exchange of contents on the basis of a content management system through the use of the Learning Objects Metadata standards (LOM. Funding is provided by the Federal Ministry for Education and Research (FKZ NM054A. [german] Das Projekt LaMedica ( hat zum Ziel, eine multimediale Lehr- und Lernplattform zu entwickeln, Inhalte für die Medizin zu erstellen und diese in die Lehre zu implementieren. Es wurde eine on-line Autorenumgebung geschaffen, die sehr unterschiedliche didaktische Ansätze unterstützt: systematische und vernetzte Wissensvermittlung, fallbasiertes Lernen, Erstellung von Vorlesungen und Lernerfolgskontrolle. Die Lehrinhalte können zielgruppenspezifisch aufbereitet und dargestellt werden und richten sich insbesondere an Studenten, Ärzte in der Weiterbildung und Fachärzte. Eine on-line Medien-Datenbank unterstützt die Wiederverwendung und den Austausch von Inhalten auf der Basis eines Content-Management-Systems durch Verwendung des Learning Objects Metadata Standards (LOM. Die Förderung erfolgt durch das BMBF (FKZ NM054A.

  7. Reversible renal impairment induced by treatment with the angiotensin II receptor antagonist candesartan in a patient with bilateral renal artery stenosis

    Directory of Open Access Journals (Sweden)

    Kjaer Andreas

    2001-05-01

    Full Text Available Abstract Background It is well established that ACE-inhibitors should be avoided in patients with renal artery stenosis. In recent years it has also been recommended that caution should be demonstrated when angiotensin II blockers are used in the same type of patients but the evidence is based only on few cases. Results We describe a case where use of the angiotensin II antagonist candesartan (Atacand induced renal failure in a patient with bilateral renal artery stenosis. The course of the case is enlighted by results from sequential renography, selective renal vein catheterisation for measurement of renin, and angiographic findings. Conclusions In patients with renal artery stenosis the angiotensin II antagonist candesartan should be avoided.

  8. Alshamel fi Sana’at Tebbi’at: A Comprehensive Book on the Materia Medica

    Science.gov (United States)

    Mosaffa-Jahromi, Maryam; Kiani, Hossein

    2016-01-01

    Background: Ala-al-din abu Al-Hassan Ali ibn Abi-Hazm al-Qarshi al-Dimashqi, known as Ibn al-Nafis (1210-1288 AD), was a Muslim Syrian physician primarily famous for being the first to describe the pulmonary circulation of the blood. The most voluminous of his books is Alshamel fi Sana’at tebbi’at, which is a comprehensive medical encyclopedia. It comprised 300 volumes of notes, from which only 80 volumes are published. His writings are cataloged in many libraries around the world. The aim of this review article, as a tribute to Ibn al-Nafis, was to introduce his valuable but neglected encyclopedia of Materia Medica. Methods: Ibn al-Nafis’ traditional approach in his “Alshamel fi Sana’at tebbi’at” book is studied in the present article. Results: Alshamel fi Sana’at tebbi’at covers three branches of knowledge. The first category is devoted to theoretical traditional medicine. The second is in four sections where much of it is not available yet. The third category is on Materia Medica covering the aspect of Unani medicine, from which only 28 volumes of the comprehensive book on the traditional medicine have been found so far. The latter, introduces mono-ingredient medications in alphabetical order. Each chapter, in several parts, is dedicated to the botanical characteristics and nature of each mono-ingredient medication. In addition, this book explains traditional pharmacokinetic of every single medication for each human body organs. Conclusion: Based on pharmaco-mechanistic perspective on Alshamel fi Sana’at tebbi’at, it could be considered as the main reference book on traditional medicine and pharmacy, worthy of revival. PMID:27516653

  9. Acta informatica medica is indexed in pubmed and archived in pubmed central.

    Science.gov (United States)

    Masic, Izet

    2013-03-01

    Acta Informatica Medica journal has been accepted for archiving in PubMed Central from 2011 onward. The journal started in 1993 as the official journal of the Society for Medical Informatics of Bosnia and Herzegovina. During the last 3 years, Acta Informatica Medica has een included in almost all prestigious online databases, including PubMed, Scopus and EMBASE. The 20th volume of the journal is fully international, with papers from 18 countries.

  10. META-ANALYSIS OF THE SCIENTIFIC CONTENTS OF MATERIA SOCIO-MEDICA JOURNAL IN THE PERIOD 2009–2015

    Science.gov (United States)

    Masic, Izet; Begic, Edin; Zunic, Lejla; Donev, Doncho

    2016-01-01

    Introduction: Materia Socio Medica Journal has a long history. It was founded in 1978. Aim: To evaluate journal articles in 2015 and compare findings to previous years. Material and methods: The study has retrospective and descriptive character, and included the period 2009-2015. Results: A total of 99 articles were published in Materia Socio Medica during 2015 and it shows an upward trend during the period 2009-2015. Original articles are present in majority during the last seven years (69,2%). Analyzing the last seven years, 44,1% of articles were from the field of clinical medicine. Articles from the fields of public health show an upward trend during the last four years. Collaboration rate in 2015 was 0,95. Authors of the articles are from ten countries (four continents). H index of journal is 8 and g index is 12 (Publish or Perish software). According to GoogleScholar, h5 index for Materia Socio Medica is 8 and h5 median is 9. Conclusions: The objectives of the journal in the next year are: to become a part of the Scopus and Web of Science databases, further internationalization and promotion of the journal in the country and the region, revision and broadening of the Editorial Board, trying to follow trend in reducing the number of days required for a decision on acceptance or revision of article and involvement of the younger generation of professionals and scientists into the journal work and publishing scope, which will lead to emergence of new enthusiasm and ideas (Journal intends to follow the trends of modern biomedical publishing worldwide). PMID:27047258

  11. Extraction, Modelling and Purification of Flavonoids from Citrus Medica Peel

    Directory of Open Access Journals (Sweden)

    M. Parvathi Nandan

    2015-12-01

    Full Text Available Soxhlet extraction technique is widely employed for the extraction and separation of chemical constituents in the medicinal plants. Citrus medica L commonly called as Citron belongs to family Rutaceae, is a slow-growing shrub. It is mainly cultivated for the production of edible fruits which are sour in taste like lime and lemon and the main content of a citron fruit is the thick rind, which is very adherent to the segments. From the phytochemical analysis the peel extract is rich source of phenols, flavonoids and alkaloids. The objective of present work is to develop a modelling equation for quercetin, rutin and kaempferol and the crude extract obtained by soxhlet extraction was further purified by solvent-solvent extraction and Column chromatography. Extraction was carried out by 80% methanol as a solvent Soxhlet extractor. Soxhlet extraction with methanol was carried out with varying time intervals, to evaluate modelling equation. The proposed modelling equation was Es = 0.0849(t + 7.0286 for Quercetin and Es = 0.0912(t + 25.971 for rutin, and Es = 0.0267(t + 7.3714 for Kaempferol. High yield was obtained for 180min of Soxhlet extraction with 80% methanol. Yield of quercetin, rutin and kaempferol after solvent-solvent extraction and column chromatography was 22.6µg/ml, 43.7µg/ml and 10.8µg/ml respectively. The proposed model showed good agreement with the experimental data.

  12. Dialetic Materia Medica Materia Médica Dialéctica Matéria Médica Dialética

    Directory of Open Access Journals (Sweden)

    Gilberto Ribeiro Vieira

    2005-01-01

    Full Text Available Objective: To propose a methodology for investigating the more important symptoms of a materia medica and understanding the inter-relation between these data.Material: 1 Homeopathic: pathogenesic symptoms,clinical materia medica, repertory, published studies in magazines, including clinical cases. 2 Dialectic principles: antagonism,gradation and analogy. 3 Dictionaries.Methods: it takes some symptoms are select in order to exemplify each one of the dialectic principles. Then, two groups are formed, which correspond to the inverse and complementary halves of one and the same theme.Results: it is formed the Bipolar Picture with symptoms of both poles.

  13. Validated spectrofluorimetric determination of two pharmaceutical antihypertensive mixtures containing amlodipine besylate together with either candesartan cilexetil or telmisartan.

    Science.gov (United States)

    Belal, Tarek S; Mahrous, Mohamed S; Abdel-Khalek, Magdi M; Daabees, Hoda G; Khamis, Mona M

    2014-11-01

    Amlodipine besylate (AML) is available in fixed-dose combination tablets with either candesartan cilexetil (CAN) or telmisartan (TEL). This work describes a simple, selective and sensitive spectrofluorimetric method for analysis of AML/CAN and AML/TEL binary mixtures without prior separation. The method involves measurement of the native fluorescence of AML at excitation and emission wavelengths of 367 and 454 nm, respectively, in water without interference from either of the two drugs. By contrast, the intrinsic fluorescence of CAN was measured at excitation and emission wavelengths of 265 and 392 nm, respectively, in ethanol, while TEL was measured at 366 nm in 0.05 M sodium hydroxide solution using 294 nm as the excitation wavelength. The proposed spectrofluorimetric procedure was validated with respect to linearity, ranges, precision, accuracy, selectivity, robustness, detection and quantification limits. Regression analysis showed a good correlation between fluorescence intensity and concentration over the ranges 0.1-1.4, 0.025-0.25 and 0.0025-0.05 µg/mL for AML, CAN and TEL, respectively. Limits of detection were 0.034, 0.0063 and 0.0007 µg/mL for AML, CAN and TEL, respectively. The proposed method was successfully applied for the analysis of several synthetic binary mixtures of different ratios and laboratory-prepared tablets with good recoveries, and no interference from common pharmaceutical additives was observed. PMID:24615878

  14. Clinical and radiographical evaluation of mineral trioxide aggregate, biodentine and propolis as pulpotomy medicaments in primary teeth

    Science.gov (United States)

    Rakesh, Kumar; Richa, Khanna

    2015-01-01

    Objectives The purpose of this study was to evaluate the efficacy of mineral trioxide aggregate (MTA), Biodentine and Propolis as pulpotomy medicaments in primary dentition, both clinically and radiographically. Materials and Methods A total of 75 healthy 3 to 10 yr old children each having at least one carious primary molar tooth were selected. Random assignment of the pulpotomy medicaments was done as follows: Group I, MTA; Group II, Biodentine; Group III, Propolis. All the pulpotomized teeth were evaluated at 3, 6, and 9 mon clinically and radiographically, based on the scoring criteria system. Results The clinical success rates were found to be similar among the three groups at 3 and 6 mon where as a significant decrease in success rate was observed in Group III (84%) compared to both Group I (100%) and Group II (100%) at 9 mon. Radiographic success rates over a period of 9 mon in Groups I, II, and III were 92, 80, and 72%, respectively. Conclusions Teeth treated with MTA and Biodentine showed more favorable clinical and radiographic success as compared to Propolis at 9 mon follow-up. PMID:26587413

  15. [Textual research on adulteration of Chinese materia medica in ancient China].

    Science.gov (United States)

    Xie, Jin; Wang, De-Qun

    2013-09-01

    By investigating the mainstream works of herbal classics of successive ages, it is found that adulteration of Chinese materia medica appeared early in ancient China. The main methods of adulteration was producing fraud medicines in the Northern-Southern Dynasties, fake medicines began to appear in the Tang Dynasty, and status of adulteration of Chinese materia medica ran unchecked since the Ming and Qing Dynasty. By statistics, there were 76 kinds of adulteration varieties before the Republican period. The main varieties were precious drugs, animal drugs and artifacts. Commonly methods used in the process included forging and adulterating, dealing with 11 kinds and 68 kinds respectively. Adulteration probably lead to the result of imposing the changes of the used medicinal parts of Herba Pogostemonis; Radix Aconiti Lateralis prepared by adding salt, Radix Angelica Sinensis processed by wine, and Radix Astragalis seu Hedysaris processed with bee honey. However, the root cause of adulteration in Chinese materia medica was the dissociation of professional physician and pharmacist, resulting in the ignorance of medical practitioners became unable to recognize Chinese materia medica; and the immorality of medicinal merchants. Besides, rating the quality of materia medica based on its producing areas without differentiating the false from the genuine may also contribute to this result passively.

  16. [Textual research on adulteration of Chinese materia medica in ancient China].

    Science.gov (United States)

    Xie, Jin; Wang, De-Qun

    2013-09-01

    By investigating the mainstream works of herbal classics of successive ages, it is found that adulteration of Chinese materia medica appeared early in ancient China. The main methods of adulteration was producing fraud medicines in the Northern-Southern Dynasties, fake medicines began to appear in the Tang Dynasty, and status of adulteration of Chinese materia medica ran unchecked since the Ming and Qing Dynasty. By statistics, there were 76 kinds of adulteration varieties before the Republican period. The main varieties were precious drugs, animal drugs and artifacts. Commonly methods used in the process included forging and adulterating, dealing with 11 kinds and 68 kinds respectively. Adulteration probably lead to the result of imposing the changes of the used medicinal parts of Herba Pogostemonis; Radix Aconiti Lateralis prepared by adding salt, Radix Angelica Sinensis processed by wine, and Radix Astragalis seu Hedysaris processed with bee honey. However, the root cause of adulteration in Chinese materia medica was the dissociation of professional physician and pharmacist, resulting in the ignorance of medical practitioners became unable to recognize Chinese materia medica; and the immorality of medicinal merchants. Besides, rating the quality of materia medica based on its producing areas without differentiating the false from the genuine may also contribute to this result passively. PMID:24429032

  17. RESEARCH ON MATERIAL MEDICA OF PERICARPIUM CITRI RETICULATAE%陈皮本草考证

    Institute of Scientific and Technical Information of China (English)

    魏莹; 杨安金; 骆利平; 李正红; 龚千锋; 杨武亮

    2013-01-01

    The research on the origin of pericarpium citri reticulatae’s name, the variety, the geo-herbalism and the effect was done through looking up Chinese ancient agrostology and modern literatures. The results showed that the name of pericarpium citri reticulatae was based on some certain literatures such as China pharmacopoeia. Therefore, it is reasonable that Citrus reticulate Blanco was formally loaded into China pharmacopoeia published in 2010. Material medica had recorded that pericarpium citri reticulatae coming from Xinhui, Guangdong Province was better. So the current genuine producing areas and the effect were the same basically. There are many arguments on whether tangerine peel needs to be kept and how long it was kept all the time. The aim of this study was to expect to provide basis for material medica for the further clinical application of pericarpium citri reticulatae.%通过查阅古代本草并且结合近现代文献对陈皮名称源流、品种、道地性、功效主治进行考证,结果发现:历版中国药典均以陈皮为正名具有文献依据;2010版药典将陈皮Citrus reticulata Blanco作为正品收载使用具有一定道理;本草记载的陈皮以广东新会为胜,这与现在陈皮的道地产区相吻合;功效主治与目前基本一致。从古至今对陈皮是否存放;若需存放,存放时间这一问题多有争议。本研究对这一问题提出自己的看法,以期对陈皮的进一步临床应用提供本草依据。

  18. Determination of related substances in Candesartan Cilexetil Tablets%HPLC法测定坎地沙坦酯片中有关物质

    Institute of Scientific and Technical Information of China (English)

    房思萌; 苏慕君; 臧可昕

    2014-01-01

    目的:分析对比多国药典改进HPLC法测定坎地沙坦酯及其片剂中有关物质的方法。方法采用HPLC法对坎地沙坦酯及其片剂中9个杂质进行测定。Waters Symmetry C18色谱柱(150 mm×4.6 mm,5μm);流动相:[乙腈-水-冰醋酸(57∶43∶1)]-[乙腈-水-冰醋酸(90∶10∶1)],梯度洗脱;体积流量:0.9 mL/min;柱温:35℃;样品仓温度:10℃;进样量:20μL;检测波长:254 nm。结果在选定的色谱条件下,坎地沙坦酯与有关物质分离良好。试验专属性、线性、耐用性良好。结论本研究可为坎地沙坦酯片的质量标准的制订和提高提供参考和依据。%Objective To optimize the HPLC method to determinate the related substances in candesartan cilexetil and its tablets compared with the national pharmacopoeias.Methods Nine impurities in Candesartan Cilexetil Tablets were separated and identified by HPLC. Chromatographic separation was carried out on an Waters Symmetry C18 column (150 mm × 4.6 mm, 5μm) at a flow rate of 0.9 mL/min. [Acetonitrile - water - acetic acid glacial (57∶43∶1)]-[acetonitrile - water - acetic acid glacial (90∶10∶1)] was used as mobile phase. It was monitored at a wavelength of 254 nm, the temperatures of column and sample chamber were 35 and 10℃, and the injection volume was 20μL..Results There was good separation among candesartan cilexetil and related substances under the chromatographic conditions. The method had good specificity, linearity, and durability.Conclusion It provides reference and basis to develop and improve the quality control of Candesartan Cilexetil Tablets.

  19. Inferring Phylogenetic Relationships of Indian Citron (Citrus medica L.) based on rbcL and matK Sequences of Chloroplast DNA.

    Science.gov (United States)

    Uchoi, Ajit; Malik, Surendra Kumar; Choudhary, Ravish; Kumar, Susheel; Rohini, M R; Pal, Digvender; Ercisli, Sezai; Chaudhury, Rekha

    2016-06-01

    Phylogenetic relationships of Indian Citron (Citrus medica L.) with other important Citrus species have been inferred through sequence analyses of rbcL and matK gene region of chloroplast DNA. The study was based on 23 accessions of Citrus genotypes representing 15 taxa of Indian Citrus, collected from wild, semi-wild, and domesticated stocks. The phylogeny was inferred using the maximum parsimony (MP) and neighbor-joining (NJ) methods. Both MP and NJ trees separated all the 23 accessions of Citrus into five distinct clusters. The chloroplast DNA (cpDNA) analysis based on rbcL and matK sequence data carried out in Indian taxa of Citrus was useful in differentiating all the true species and species/varieties of probable hybrid origin in distinct clusters or groups. Sequence analysis based on rbcL and matK gene provided unambiguous identification and disposition of true species like C. maxima, C. medica, C. reticulata, and related hybrids/cultivars. The separation of C. maxima, C. medica, and C. reticulata in distinct clusters or sub-clusters supports their distinctiveness as the basic species of edible Citrus. However, the cpDNA sequence analysis of rbcL and matK gene could not find any clear cut differentiation between subgenera Citrus and Papeda as proposed in Swingle's system of classification. PMID:26956119

  20. Antimanic-like activity of candesartan in mice: Possible involvement of antioxidant, anti-inflammatory and neurotrophic mechanisms.

    Science.gov (United States)

    de Souza Gomes, Júlia Ariana; de Souza, Greicy Coelho; Berk, Michael; Cavalcante, Lígia Menezes; de Sousa, Francisca Cléa F; Budni, Josiane; de Lucena, David Freitas; Quevedo, João; Carvalho, André F; Macêdo, Danielle

    2015-11-01

    Activation of the brain angiotensin II type 1 receptor (AT1R) triggers pro-oxidant and pro-inflammatory mechanisms which are involved in the neurobiology of bipolar disorder (BD). Candesartan (CDS) is an AT1 receptor antagonist with potential neuroprotective properties. Herein we investigated CDS effects against oxidative, neurotrophic inflammatory and cognitive effects of amphetamine (AMPH)-induced mania. In the reversal protocol adult mice were given AMPH 2 mg/kg i.p. or saline and between days 8 and 14 received CDS 0.1, 0.3 or 1 mg/kg orally, lithium (Li) 47.5 mg/kg i.p., or saline. In the prevention treatment, mice were pretreated with CDS, Li or saline prior to AMPH. Locomotor activity and working memory performance were assessed. Glutathione (GSH), thiobarbituric acid-reactive substance (TBARS) and TNF-α levels were evaluated in the hippocampus (HC) and cerebellar vermis (CV). Brain-derived neurotrophic factor (BDNF) and glycogen synthase kinase 3-beta (GSK-3beta) levels were measured in the HC. CDS and Li prevented and reversed the AMPH-induced increases in locomotor activity. Only CDS prevented and reversed AMPH-induced working memory deficits. CDS prevented AMPH-induced alterations in GSH (HC and CV), TBARS (HC and CV), TNF-α (HC and CV) and BDNF (HC) levels. Li prevented alterations in BDNF and phospho-Ser9-GSK3beta. CDS reversed AMPH-induced alterations in GSH (HC and CV), TBARS (HC), TNF-α (CV) and BDNF levels. Li reversed AMPH-induced alterations in TNF-α (HC and CV) and BDNF (HC) levels. CDS is effective in reversing and preventing AMPH-induced behavioral and biochemical alterations, providing a rationale for the design of clinical trials investigating CDS׳s possible therapeutic effects.

  1. Antimanic-like activity of candesartan in mice: Possible involvement of antioxidant, anti-inflammatory and neurotrophic mechanisms.

    Science.gov (United States)

    de Souza Gomes, Júlia Ariana; de Souza, Greicy Coelho; Berk, Michael; Cavalcante, Lígia Menezes; de Sousa, Francisca Cléa F; Budni, Josiane; de Lucena, David Freitas; Quevedo, João; Carvalho, André F; Macêdo, Danielle

    2015-11-01

    Activation of the brain angiotensin II type 1 receptor (AT1R) triggers pro-oxidant and pro-inflammatory mechanisms which are involved in the neurobiology of bipolar disorder (BD). Candesartan (CDS) is an AT1 receptor antagonist with potential neuroprotective properties. Herein we investigated CDS effects against oxidative, neurotrophic inflammatory and cognitive effects of amphetamine (AMPH)-induced mania. In the reversal protocol adult mice were given AMPH 2 mg/kg i.p. or saline and between days 8 and 14 received CDS 0.1, 0.3 or 1 mg/kg orally, lithium (Li) 47.5 mg/kg i.p., or saline. In the prevention treatment, mice were pretreated with CDS, Li or saline prior to AMPH. Locomotor activity and working memory performance were assessed. Glutathione (GSH), thiobarbituric acid-reactive substance (TBARS) and TNF-α levels were evaluated in the hippocampus (HC) and cerebellar vermis (CV). Brain-derived neurotrophic factor (BDNF) and glycogen synthase kinase 3-beta (GSK-3beta) levels were measured in the HC. CDS and Li prevented and reversed the AMPH-induced increases in locomotor activity. Only CDS prevented and reversed AMPH-induced working memory deficits. CDS prevented AMPH-induced alterations in GSH (HC and CV), TBARS (HC and CV), TNF-α (HC and CV) and BDNF (HC) levels. Li prevented alterations in BDNF and phospho-Ser9-GSK3beta. CDS reversed AMPH-induced alterations in GSH (HC and CV), TBARS (HC), TNF-α (CV) and BDNF levels. Li reversed AMPH-induced alterations in TNF-α (HC and CV) and BDNF (HC) levels. CDS is effective in reversing and preventing AMPH-induced behavioral and biochemical alterations, providing a rationale for the design of clinical trials investigating CDS׳s possible therapeutic effects. PMID:26321203

  2. [Revision to origin of northern Artemisia argyi in Compendium of Materia Medica (Bencao gangmu)].

    Science.gov (United States)

    Huang, Lu-qi; Qiu, Le

    2014-12-01

    The origin of northern Artemisia argyi recorded in Compendium of Materia Medica(Bencao gangmu) is Fudao(Chinese characters) in Tangyin county, While there is only Fudao(Chinese characters) instead of Fudao(Chinese characters). Whether indeed Fudao(Chinese characters) is Fudao(Chinese characters)? By reviewing the genuine evolution of A. argyi, doing textual research on Fudao(Chinese characters) and combing with field survey data of national census of Chinese Materia Medica resources, this paper concluded that the word Fudao(Chinese characters) firstly emerged in Figure Canon of Chinese Materia Medica(Bencao tujing) of Susong in Song dynasty and was applied in later generations, but the implication was not clear, then emerged both Tangyin and Fudao(Chinese characters) in Compendium of Materia Medica(Bencao gangmu). The place Fudao(Chinese characters) is one of the graves of Bianque, that existed from Shang and Zhou dynasty and never changed until now, the A. argyi of Tangyin was famous from the grave of Bianque in Fudao(Chinese characters), which could infer that Lishizhen considered Fudao (Chinese characters) was Fudao(Chinese characters) indeed, and the origin of northern A. argyi was Fudao(Chinese characters) in Tangyin county. PMID:25898599

  3. [Discussion on sources of texts of Meng Sheng's Herbology of dietotherapy cited in Jinling edition of Compendium of materia medica].

    Science.gov (United States)

    Shang, Z

    2000-07-01

    Most of the citations of Meng Sheng's Herbology of Dietotherapy in Compendium of Materia Medica are originated from the Daguan Herbology and Zhenghe Herbology. When comparing these sources of citations in Compendium of Materia Medica with the texts in Daguan and Zhenghe, it can be found that there are differences, In Compendium of Materia Medica, it is indicated that these sources marked "Meng Sheng's Herbology of Dietotherapy" are actually derived from other sources, while citations from other sources are marked "Meng Sheng's Herbology of Dietotherapy" which are not found in Classified Herbology (Zhenglei ben cao). This might be due to the editions of Daguan and Zhenghe Li Shizhen applied are different. PMID:11624691

  4. RP-HPLC METHOD FOR SIMULTATANEOUS DETERMINATION OF ATORVASTATIN CALCIUM, OLMESARTAN MEDOXOMIL, CANDESARTAN, HYDROCHLOROTHIAZIDE AND CHLORTHALIDONE – APPLICATION TO COMMERCIALLY AVAILABLE DRUG PRODUCTS

    Directory of Open Access Journals (Sweden)

    R.A. Mhaske et al.

    2012-03-01

    Full Text Available A simple, precise and stability-indicating HPLC method was developed and validated for the simultaneous determination of anti-hypertensive drugs Atorvastatin Calcium, Olmesartan Medoxomil, Candesartan, diuretics Hydrochlorothiazide and Chlorthalidone. The separation was achieved on Cosmosil PAQ (Length 150 mm × Diameter 4.6 mm Particle size 5 μm column with gradient flow. The mobile phase at a flow rate of 1.0 mL min−1 consisted of 0.05 M sodium dihydrogen phosphate buffer and acetonitrile (Gradient ratio. The UV detection was carried out at 220 nm. The method was successfully validated in accordance to ICH guidelines. Further, the validated method was applied for commercially available pharmaceutical dosage form.

  5. A theoretical and experimental study on the Fuzzy evaluation model of biological performance of Chinese materia medica with an either cold or hot herbal property%中药寒热药性表达模糊评价模式的理论与实验研究

    Institute of Scientific and Technical Information of China (English)

    金锐; 张冰; 刘小青; 薛春苗; 张倩; 李连珍; 赵茜; 李康

    2012-01-01

    OBJECTIVE: The concepts of cold and hot herbal properties in traditional Chinese medicine (TCM), reflecting the efficacy trends of medicinal herbs, have the Fuzzy characteristics. It is suited for the application of Fuzzy mathematics in research of herbal properties. For a comprehensive evaluation of herbal properties, this work constructed and made a practice of the Fuzzy discrimination model regarding the biological performance of Chinese materia medica.METHODS: Firstly, TCM formulas of cold or hot property were employed for setting the reference values and calculating the membership functions of cold and hot Fuzzy sets with Fisher discriminant. Then the model parameters of cold performance function (CPF) and hot performance function (HPF) were acquired. Second, the experimental data from studies on changes in multisystem indicators of animals given the classical cold formula (Sanhuang Fang) and hot formula (Jiangfugui Fang) were collected to calculate CPF and HPF. Then an experiment of administration of hot property herbs, Rougui (Cortex Cinnamomi) and Xianmao (Rhizoma Curculiginis), and cold property herbs, Huangbai (Cortex Phellodendri) and Zhizi (Fructus Gardeniae) to normal animals and animals with glucocorticoid-induced yang-deficiency or yin-deficiency state was designed. The relative changes in animal states were analyzed by the evaluation model to find the way in which herbal properties are represented.RESULTS: The HPF values of biological performance were higher than the CPF values in administration of Rougui to animals of normal (0. 528>0. 221), yang-deficiency (0. 203> -0. 490) and yin-deficiency (1.750 > -0.479) states, and in administration of Xianmao to animals of normal (0. 474> - 1. 601) and yang-deficiency (0. 288 > -1. 923) states, which represented the hot property. The HPF values of biological performance were lower than the CPF values in administration of Huangbai to animals of normal ( - 0. 870< 0.798) and yang-deficiency ( - 0.339<0. 194

  6. [Research on the origins and development of the verse "eighteen antagonism" in Chinese material medica].

    Science.gov (United States)

    Yang, Huan; Fan, Xin-Sheng; Bian, Ya-Li; Li, Yun; Jiang, Chen-Xue

    2013-03-01

    The verse "eighteen antagonism" of Chinese materia medica is a kind of describing of drug nature concerning the incompatibility of drugs in compound prescription. Through organizing the medical books in different historical periods, it is found that the drugs in this verse basically coming from TAO Hong-jing's ben cao jing ji zhu (Variorum of Shennong's Classic of Materia Medica), while the style of verse mostly appeared during the Song-Jin-Yuan period was made. The formed verse was explained and supplemented further in the Ming Dynasty, the basis of which appeared in the Song-Jin-Yuan Dynasty, resulting in the increase of the number of antagonistic drugs and lengthy verse. The origin of the verse seen in Ru men shi qin (Confucians' Duties to Their Parents) and those in other books was not identical and was the most popular one after the Qing Dynasty, becoming the most popularly known even today. PMID:24135473

  7. Industry Development and Health of Chinese Materia Medica and Natural Products

    Institute of Scientific and Technical Information of China (English)

    Tianjin Press of Chinese Herbal Medicines

    2010-01-01

    @@ In order to push forward the research and development of innovative drugs, to re-exploit large species, and to invent healthy product, Tianjin Pharmaceutical Association, Tianjin Plant Association, and Tianjin Press of Chinese Herbal Medicines sponsored the meeting “Circum-Bohai Industry Development and Health of Chinese Materia Medica and Natural Products”. It will be held during May 28-30, 2010. Some famous experts will be invited to make speeches and to communicate with participants.

  8. Tinjauan higiene dan Sanitasi Dalam Penyelenggaraan Makanan Di Instalasi Gizi RSU Artha Medica Binjai Tahun 2010

    OpenAIRE

    Agustria

    2010-01-01

    Hospital as one of health institution has a duty that support in medical patient healing and recovering by institutional food service healthy and hygiene food. Because of that, it needs to managed the healthy food and fulfill the condition of standard sanitation for hygiene food. The purpose for this research was for hygiene evaluation and food processing sanitation at Nutrition Instalation of Artha Medica Hospital Binjai in completing hygiene quality standard and managed sanitation food...

  9. Culture Technology of Citrus medica var.sarcodactylis%佛手丰产栽培技术

    Institute of Scientific and Technical Information of China (English)

    邹文武; 朱雯

    2014-01-01

    文章介绍了佛手的生物学特性、种苗繁育、栽植技术和主要病虫害防治等,为佛手栽培种植提供技术指导。%Cultrue technology of Citrus medica var.sarcodactylis was introduced in this article,which in-cluding technology in seedling breeding,planting and method of main disease and pest control.

  10. An Update on the Management of Endodontic Biofilms Using Root Canal Irrigants and Medicaments

    OpenAIRE

    Mohammadi, Zahed; Soltani, Mohammad Karim; Shalavi, Sousan

    2014-01-01

    Microbial biofilm is defined as a sessile multicellular microbial community characterized by cells that are firmly attached to a surface and enmeshed in a self-produced matrix of extracellular polymeric substances. Biofilms play a very important role in pulp and periradicular pathosis. The aim of this article was to review the role of endodontic biofilms and the effects of root canal irrigants, medicaments as well as lasers on biofilms A Medline search was performed on the English articles pu...

  11. Consumer’s intentions to shop medicaments on-line: A survey from Czech Republic market

    Directory of Open Access Journals (Sweden)

    Jan Svorc

    2012-04-01

    Full Text Available This paper seeks to identify what are the main determinants of the consumer’s intentions to shop medicaments online in Czech Republic; grounded mainly on theoretical models such as Technology Acceptance Model this research specifically aims to identify whether there are relations between these intentions and perceived usefulness, perceived ease of use, perceived risk, past experience, consumer trust and consumer social norms. Second goal is to identify whether there are differences in intentions to buy medicaments online among the main demographic groups based on age, gender, income and education in Czech Republic. The questionnaire survey method was used. Data collected were analysed using correlation and regression analysis to determine the significance of the relationship between the respective variables. Demographic group’s differences were analysed using t-test and analysis of variance. The results showed that the significant relations exist between consumer’s intention to shop medicaments online and all examined variables in Czech Republic. Multiple regression analysis of the model has shown that only perceived risk and perceived usefulness are the significant predictors for intention. There are no significant differences among the demographic groups based on age, gender, income and education.

  12. Sequential cloud-point extraction for toxicological screening analysis of medicaments in human plasma by high pressure liquid chromatography with diode array detector.

    Science.gov (United States)

    Madej, Katarzyna; Persona, Karolina; Wandas, Monika; Gomółka, Ewa

    2013-10-18

    A complex extraction system with the use of cloud-point extraction technique (CPE) was developed for sequential isolation of basic and acidic/neutral medicaments from human plasma/serum, screened by HPLC/DAD method. Eight model drugs (paracetamol, promazine, chlorpromazine, amitriptyline, salicyclic acid, opipramol, alprazolam and carbamazepine) were chosen for the study of optimal CPE conditions. The CPE technique consists in partition of an aqueous sample with addition of a surfactant into two phases: micelle-rich phase with the isolated compounds and water phase containing a surfactant below the critical micellar concentration, mainly under influence of temperature change. The proposed extraction system consists of two chief steps: isolation of basic compounds (from pH 12) and then isolation of acidic/neutral compounds (from pH 6) using surfactant Triton X-114 as the extraction medium. Extraction recovery varied from 25.2 to 107.9% with intra-day and inter-day precision (RSD %) ranged 0.88-1087 and 5.32-17.96, respectively. The limits of detection for the studied medicaments at λ 254nm corresponded to therapeutic or low toxic plasma concentration levels. Usefulness of the proposed CPE-HPLC/DAD method for toxicological drug screening was tested via its application to analysis of two serum samples taken from patients suspected of drug overdosing.

  13. Identification of Sinorhizobium (Ensifer) medicae based on a specific genomic sequence unveiled by M13-PCR fingerprinting.

    Science.gov (United States)

    Dourado, Ana Catarina; Alves, Paula I L; Tenreiro, Tania; Ferreira, Eugénio M; Tenreiro, Rogério; Fareleira, Paula; Crespo, M Teresa Barreto

    2009-12-01

    A collection of nodule isolates from Medicago polymorpha obtained from southern and central Portugal was evaluated by M13-PCR fingerprinting and hierarchical cluster analysis. Several genomic clusters were obtained which, by 16S rRNA gene sequencing of selected representatives, were shown to be associated with particular taxonomic groups of rhizobia and other soil bacteria. The method provided a clear separation between rhizobia and co-isolated non-symbiotic soil contaminants. Ten M13-PCR groups were assigned to Sinorhizobium (Ensifer) medicae and included all isolates responsible for the formation of nitrogen-fixing nodules upon re-inoculation of M. polymorpha test-plants. In addition, enterobacterial repetitive intergenic consensus (ERIC)-PCR fingerprinting indicated a high genomic heterogeneity within the major M13- PCR clusters of S. medicae isolates. Based on nucleotide sequence data of an M13-PCR amplicon of ca. 1500 bp, observed only in S. medicae isolates and spanning locus Smed_3707 to Smed_3709 from the pSMED01 plasmid sequence of S. medicae WSM419 genome's sequence, a pair of PCR primers was designed and used for direct PCR amplification of a 1399-bp sequence within this fragment. Additional in silico and in vitro experiments, as well as phylogenetic analysis, confirmed the specificity of this primer combination and therefore the reliability of this approach in the prompt identification of S. medicae isolates and their distinction from other soil bacteria. PMID:20112226

  14. Interações farmacológicas entre medicações clínicas e psiquiátricas Drug interactions among clinical and psychiatric drugs

    Directory of Open Access Journals (Sweden)

    Marco Antonio Marcolin

    2004-01-01

    Full Text Available INTRODUÇÃO/JUSTIFICATIVA: Estudos apontam as reações adversas graves (ADR como uma das seis causas de morte em pacientes hospitalizados nos EUA, sendo que das ADR, a mais freqüente inclui as Interações Medicamentosas (IM. MÉTODOS: foram cruzadas 20 medicações mais utilizadas em andares clínicos do Hospital Universitário São Lucas da PUCRS com 14 medicações mais utilizadas no Ambulatório de Depressão do HSL-PUCRS; pesquisou-se no Medline e Lilacs a partir de 1990. RESULTADOS: foram encontradas diversas IM com muitas das medicações estudadas, envolvendo freqüentemente o Sistema Citocromo P450. CONCLUSÕES: conclui-se que a atualização sobre as medicações utilizadas em nossa prática clínica vai muito além dos efeitos esperados e efeitos colaterais mais freqüentes.BACKGROUND/JUSTIFICATION: Studies point up the serious adverse reactions (ADR as one of the six main causes of death of hospitalized patients in the United States. The most frequent ADR include the drug interaction. METHODS: twenty most used medications were compared, in a certain period of time, at the clinical sector of São Lucas Universitary Hospital of PUC-RS, to the fourteen most used ones at the Ambulatório de Depressão (ADe of the same hospital. The research gathered information published since 1990 in Medline and Lilacs. RESULTS: several drug interactions were found among many of the studied medications, often involving the Cytochrome P450 System. CONCLUSION: the update of the medication on clinic use goes further than the expected results or the most frequent collateral effects.

  15. Status and Trends of GAP Base Construction of Chinese Materia Medica in Guangdong Province

    Institute of Scientific and Technical Information of China (English)

    DING Ping; LAI Xiao-ping; XU Hong-hua; DU Qin; WANG Jian-gang; YING Ge; LIAO Hui-jun; DAI Lei; SHAO Yan-hua

    2012-01-01

    It is one of the key points for modernization and internationalization of traditional Chinese medicines to construct the Good Agricultural Practice (GAP) base of Chinese materia medica (CMM).GAP helps to minimize contamination and improve the quality of CMM during the plantation and the production of Chinese crude drugs.In this article,the status and development of CMM production bases of GAP in Guangdong Province,China,are presented.The suggestions upon the problems during the development of GAP for Chinese crude drugs are also provided.

  16. Medical Business Ethics in the XXI century; Deontologia medica del siglo XXI

    Energy Technology Data Exchange (ETDEWEB)

    Moya Pueyo, V.

    2009-07-01

    Since ancient times the medical professional practice included moral rules in order to assure a correct approach of capital problems. These rules evolve and are now gathered in the Deontological Codes watching the Constitution and other higher Laws. There has been an increase of interest for none strictly clinical matter since the appearance of the term Bioethics. The book Deontologia medica en el siglo XXI tackles problems of first interest in the present times, thru statistics and analysis, trying to help the medical doctors that have to take ethic decisions. (Author)

  17. Traditional Chinese materia medica: a retrospect and prospect

    Directory of Open Access Journals (Sweden)

    Dong-Lu Bay

    1991-01-01

    Full Text Available For thousands of years, traditional medicine and remedies have been practed and used in the fight against disease in China. They have proved to be valuable and the distillate of vast historical experience based on field-tested human experiments, long-term observations and clinical trials. The Chinese people belive that traditional medicine is consistent with theirown culture. Endowed with a unique theoretical system and provided outstanding clinical results, traditional Chinese medicine continues to play an important role in helping the Chinese nation flourish. The recent study of traditional medicinal plants in Chine has given us confidence that what was recorded in ancient medical literature through empirical observations is indeed still coindicent with the concepts of modern chemistry, pharmacology and medicine. The task of revealing what is valid and efficacious should be retained, and what is mythic and invalid should be discarded in traditional Chinese medicine may require scientific research lasting for several generations. Therfore, multidisciplinary cooperation and international collaboration in this field would be essential. Systematic coordination of work in traditional medicine by word organizations, national governments, private foundations and individual scientists is a requisite as well.

  18. PAT: From Western solid dosage forms to Chinese materia medica preparations using NIR-CI.

    Science.gov (United States)

    Zhou, Luwei; Xu, Manfei; Wu, Zhisheng; Shi, Xinyuan; Qiao, Yanjiang

    2016-01-01

    Near-infrared chemical imaging (NIR-CI) is an emerging technology that combines traditional near-infrared spectroscopy with chemical imaging. Therefore, NIR-CI can extract spectral information from pharmaceutical products and simultaneously visualize the spatial distribution of chemical components. The rapid and non-destructive features of NIR-CI make it an attractive process analytical technology (PAT) for identifying and monitoring critical control parameters during the pharmaceutical manufacturing process. This review mainly focuses on the pharmaceutical applications of NIR-CI in each unit operation during the manufacturing processes, from the Western solid dosage forms to the Chinese materia medica preparations. Finally, future applications of chemical imaging in the pharmaceutical industry are discussed.

  19. [Investigation on pattern of quality control for Chinese materia medica based on famous-region drug and bioassay--the work reference].

    Science.gov (United States)

    Yan, Dan; Xiao, Xiaohe

    2011-05-01

    Selection and standardization of the work reference are the technical issues to be faced with in the bioassay of Chinese materia medica. Taking the bioassay of Coptis chinensis. as an example, the manufacture process of the famous-region drugs extraction was explained from the aspects of original identification, routine examination, component analysis and bioassay. The common technologies were extracted, and the selection and standardization procedures of the work reference for the bioassay of Chinese materia medica were drawn up, so as to provide technical support for constructing a new mode and method of the quality control of Chinese materia medica based on the famous-region drugs and bioassay. PMID:21842660

  20. Receptor Antagonist of Angiotensin Ⅱ-Candesartan%血管紧张素Ⅱ受体拮抗剂-坎地沙坦

    Institute of Scientific and Technical Information of China (English)

    林平; 王小虹

    2004-01-01

    @@ Ⅰ型血管紧张素Ⅱ(AT1)受体拮抗剂是20世纪90年代进入临床的一类新型降压药物,其具有临床疗效好、毒副作用小、耐受性较好、使用方便以及可长期用于治疗高血压和有保护靶器官损害等诸多优点.目前国外已用或正在试用于临床治疗高血压病人的AT 1受体拮抗剂,主要有氯沙坦、缬沙坦、厄贝沙坦、替米沙坦、伊普沙坦和坎地沙坦等6种药物.坎地沙坦(Candesartan,商品名Blopress,必洛斯)[1,2]是由日本Takeda和瑞典Astra Zeneca公司共同研制开发,1997年11月首次在瑞典上市,后又陆续在日本、德国、美国、英国、加拿大、澳大利亚、丹麦、芬兰、瑞士、香港等国家和地区上市.本品于2003 年7月进入中国市场.现将其有关药理特性和临床应用等作一概述,供临床参考.

  1. Les gloses botaniques andalouses sur le manuscrit de Paris de la traduction arabe de la Materia Medica de Dioscorides

    Directory of Open Access Journals (Sweden)

    Ben Mrad, Ibrahim

    2009-12-01

    Full Text Available The following study focusses on a precious manuscript from the National Library in Paris, namely n.º 2849 of the Arabic manuscript collection. This is a manuscript of Andalusian origin of the Arabic translation of Materia Medica by Dioscorides, written in Syria at the beginning of the 13th century. Its margins are filled with glosses of synonymic nature, relating to the Greek terms of the plants described by the Greek pharmacologist and physician. These glosses, of Andalusian origin, offer a great terminological richness which is part of a large Arabic — mainly Andalusian — movement of revision and commentary of Materia Medica in Arabic. In the first part a general introduction to the manuscript is provided showing its significant value for a critical edition of the book, the glosses contained and, especially, of the Andalusian botanical glosses, insisting on their synonymic value and their terminological contribution. In a second part, a critical annotated edition of 44 glosses from the first maqāla of the book is proposed.

    Se aborda en este trabajo el estudio de un precioso manuscrito de la Biblioteca Nacional de París, el n.º 2849 de los fondos árabes. Se trata de un manuscrito de origen andalusí que contiene la traducción al árabe de la Materia Medica de Dioscórides, escrito en Siria a principios del siglo XIII, cuyos márgenes están repletos de glosas de naturaleza sinonímica, relativas a los nombres griegos que reciben las plantas descritas por la farmacología griega. Estas glosas son de orígen andalusí, y ofrecen una gran riqueza terminológica que se inscribe en un amplio movimiento árabe, y más concretamente andalusí, de revisión y comentario de la traducción árabe de la Materia Medica. En la primera parte de este estudio se ofrece una presentación general del manuscrito, mostrando su valor para una reedición crítica de la obra, de las glosas que contiene y

  2. Biochemia Medica has started using the CrossCheck plagiarism detection software powered by iThenticate.

    Science.gov (United States)

    Supak-Smolcić, Vesna; Simundić, Ana-Maria

    2013-01-01

    In February 2013, Biodhemia Medica has joined CrossRef, which enabled us to implement CrossCheck plagiarism detection service. Therefore, all manuscript submitted to Biodchemia Medica are now first assigned to Research integrity editor (RIE), before sending the manuscript for peer-review. RIE submits the text to CrossCheck analysis and is responsible for reviewing the results of the text similarity analysis. Based on the CrossCheck analysis results, RIE subsequently provides a recommendation to the Editor-in-chief (EIC) on whether the manuscript should be forwarded to peer-review, corrected for suspected parts prior to peer-review or immediately rejected. Final decision on the manuscript is, however, with the EIC. We hope that our new policy and manuscript processing algorithm will help us to further increase the overall quality of our Journal.

  3. Antipanic drugs and pulmonary function in panic disorder patients Medicação antipânico e função pulmonar em pacientes com transtorno de pânico

    Directory of Open Access Journals (Sweden)

    Isabella Nascimento

    2009-01-01

    Full Text Available BACKGROUND: Studies suggest an association between panic disorder (PD and impairment of lung function. OBJECTIVES: To evaluate lung function in 11 asymptomatic PD patients and to investigate antipanic drug effects on respiratory function. METHOD: Lung function was evaluated on two different occasions (with antipanic drugs and after drug washout. It was comprised of a spirometric evaluation and a bronchodilation test (salbutamol inhalation. Subjective Units of Disturbance Scale (SUDS was applied before and after each spirometric assessment. RESULTS: One patient showed mild obstructive airway impairment. Before bronchodilation test forced expiratory volume in 1 sec (FEV1 and forced expiratory flow between 25% and 75% of the forced vital capacity (FEF25-75 were significantly higher in patients on antipanic drugs than in those in the washout period. After salbutamol inhalation, only FEV1 was significantly higher in patients with antipanic drugs in comparison to the other group, whereas a significant increase in FEV1 and FEF25-75 after salbutamol inhalation was detected in patients without antipanic drugs. The subjective anxiety level was not different among PD patients in both test days. DISCUSSION: These results suggest a possible beneficial effect of the antipanic drug on lung function in PD patients.CONTEXTO: Estudos sugerem uma associação entre transtorno de pânico (TP e prejuízos na função pulmonar. OBJETIVOS: Avaliar a função pulmonar em 11 pacientes com TP assintomáticos e investigar efeitos da medicação antipânico na função respiratória. MÉTODO: A função pulmonar foi avaliada em duas ocasiões diferentes (com medicação antipânico e após "washout". Consistiu de uma avaliação espirométrica e do teste de broncodilatação (inalação de salbutamol. Subjective Units of Disturbance Scale (SUDS foi aplicada antes e após cada teste espirométrico. RESULTADOS: Um paciente apresentou obstrução leve de vias aéreas. Antes

  4. Medicação antipânico e função pulmonar em pacientes com transtorno de pânico Antipanic drugs and pulmonary function in panic disorder patients

    Directory of Open Access Journals (Sweden)

    Isabella Nascimento

    2009-01-01

    Full Text Available CONTEXTO: Estudos sugerem uma associação entre transtorno de pânico (TP e prejuízos na função pulmonar. OBJETIVOS: Avaliar a função pulmonar em 11 pacientes com TP assintomáticos e investigar efeitos da medicação antipânico na função respiratória. MÉTODO: A função pulmonar foi avaliada em duas ocasiões diferentes (com medicação antipânico e após "washout". Consistiu de uma avaliação espirométrica e do teste de broncodilatação (inalação de salbutamol. Subjective Units of Disturbance Scale (SUDS foi aplicada antes e após cada teste espirométrico. RESULTADOS: Um paciente apresentou obstrução leve de vias aéreas. Antes do teste de broncodilatação, o volume expiratório forçado no primeiro segundo (VEF1 e o fluxo expiratório forçado entre 25% e 75% da capacidade vital forçada (FEF25-75 foram significativamente maiores em pacientes com medicação antipânico do que no período de "washout". Após a inalação de salbutamol, apenas o VEF1 foi significativamente maior em pacientes com medicação antipânico em comparação ao outro grupo, embora tenha sido detectado aumento significativo em VEF1 e FEF25-75 em pacientes sem medicação antipânico depois da inalação de salbutamol. O nível de ansiedade subjetiva não foi diferente entre os pacientes em ambos os dias de testes. CONCLUSÃO: Os resultados sugerem uma possível ação benéfica da medicação antipânico na função pulmonar em pacientes com TP.BACKGROUND: Studies suggest an association between panic disorder (PD and impairment of lung function. OBJECTIVES: To evaluate lung function in 11 asymptomatic PD patients and to investigate antipanic drug effects on respiratory function. METHOD: Lung function was evaluated on two different occasions (with antipanic drugs and after drug washout. It was comprised of a spirometric evaluation and a bronchodilation test (salbutamol inhalation. Subjective Units of Disturbance Scale (SUDS was applied before and

  5. Midazolam por via oral como medicação pré-anestésica em crianças e adolescentes com paralisia cerebral: estudo comparativo das variações do índice bispectral Midazolam por vía oral como medicación preanestésica en niños y adolescentes con parálisis cerebral: estudio comparativo de las variaciones del índice bispectral Oral midazolam as pre-anesthetic medication in children and teenagers with cerebral palsy: a comparative study on the variations of the bispectral index

    Directory of Open Access Journals (Sweden)

    Verônica Vieira da Costa

    2009-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O midazolam é um derivado benzodiazepínico com ação hipnótica e muito utilizado como medicação pré-anestésica em anestesia pediátrica. As crianças com paralisia cerebral (PC também se beneficiam do uso do midazolam, mas seus efeitos são ainda desconhecidos sobre esse grupo de pacientes que apresentam uma série de particularidades, com alterações inclusive no local de ação do midazolam. O objetivo do estudo foi avaliar a ação do midazolam utilizado como medicação pré-anestésica sobre o índice bispectral (EEG-BIS dos pacientes com paralisia cerebral. MÉTODO: Foram avaliados dois grupos de pacientes: um com diagnóstico de PC e outro sem doença do sistema nervoso central (SNC e periférico. Foram registrados valores de EEG-BIS na enfermaria na véspera da operação e no dia da operação, 40 minutos depois da administração de 0,6 mg.kg-1 de midazolam via oral. Foram excluídos pacientes com história de reação paradoxal ao midazolam e pacientes do grupo-controle que estivessem em uso de outra medicação. RESULTADOS: Foram estudados 77 pacientes de ambos os sexos, entre 4 e 18 anos de idade. Não houve diferença entre os valores de EEG-BIS basal entre os grupos estudados. Após o uso do midazolam houve diminuição dos valores do EEG-BIS nos dois grupos estudados, com diferença estatística significativa em cada grupo. Na comparação entre grupos não houve diferença estatística. CONCLUSÕES: O midazolam administrado como medicação pré-anestésica na dose de 0,6 mg.kg-1 diminui os valores basais do EEG-BIS sem caracterizar hipnose e sem diferença estatística nos grupos estudados.JUSTIFICATIVA Y OBJETIVOS: El midazolam es un derivado benzodiazepínico con acción hipnótica y muy utilizado como medicación preanestésica en anestesia pediátrica. Los niños con parálisis cerebral (PC también se benefician del uso del midazolam, pero sus efectos todavía se desconocen sobre ese

  6. Effect of intracanal medicaments on push-out bond strength of Smart-Seal system

    Directory of Open Access Journals (Sweden)

    Vibha Hegde

    2015-01-01

    Full Text Available Aim: To evaluate the effects of calcium hydroxide (CH, triple and double antibiotic pastes (DAPs on the bond strength of Smart-Seal obturation, C-points with Endosequence Bio-ceramic (BC sealer to the root canal dentin. Materials and Methods: Sixty-four freshly extracted single-rooted human mandibular premolars were de-coronated and prepared using rotary Pro-taper system with full sequence till F3. The specimens were randomly divided into a control group (without intracanal dressing and 3 experimental groups that received an intracanal dressing with either CH, DAP, or triple antibiotic paste (TAP (n = 16. The intracanal dressing was removed after 3 weeks by rinsing with 10 mL 17% ethylenediaminetetraacetic acid, followed by 10 mL 3% sodium hypochlorite. The root canals were then obturated with C-points and Endosequence BC sealer. A push-out test was used to measure the bond strength between the root canal dentin and the obturating system. The data were analyzed using two-way analysis of variance and Tukey post-hoc test. Results: The push-out bond strength values were significantly affected by the intracanal medicaments (P 0.05. In the middle and apical third, the bond strength of the TAP group was higher than those of the CH and DAP groups (P < 0.05. Conclusions: The DAP and CH did not affect the bond strength of the novel hydrophilic obutrating system. TAP improved the bond strength of Smart-Seal system in the middle and apical thirds.

  7. Candesartan in heart failure: assessment of reduction in mortality and morbidity (CHARM) and resource utilization and costs in Italy

    OpenAIRE

    Colombo, Giorgio

    2008-01-01

    Giorgio L Colombo1, Mauro Caruggi2, Chiara Ottolini3, Aldo P Maggioni41S.A.V.E. Studi Analisi Valutazioni Economiche, Milano, Italy; 2Università degli Studi dell’Insubria, Varese, Italy;3Azienda Ospedaliera di Busto Arsizio, Varese, Italy; 4ANMCO Research Center, Italian Association of Hospital Cardiologists, Firenze, Italy (CHARM Steering Committee Member)Abstract: Chronic heart failure (HF) is a major cause of morbidity and mortality particularly in the elderly and a gr...

  8. Preliminary investigation on the materia medica of the Zhuang ethnic group%关于壮药的初步考察

    Institute of Scientific and Technical Information of China (English)

    容小翔; 李珪

    2013-01-01

    “壮药”是指在壮医理论指导下运用的药物.根据考古发现以及壮医学者覃保霖对《山海经·南山经》中“祝馀”、“白咎”、“迷谷”壮语发音的分析,可知在先秦时期,壮药即已存在.秦汉魏晋时期,随着区域间文化的广泛交流,壮族聚居地人民用药经验,在文献中不断体现,如《肘后方》中有关解毒药的记载,大多出自岭南.隋唐已降,本草文献和地方志中有不少记载与现今公认的壮药相似,如《广西通志》、《南宁府志》、《柳州府志》、《宾州志》等地方志中关于桂枝、肉桂、罗汉果等.民国时期,出现了不少有关壮药的手抄本.1949年之后,在党和政府的重视下,南宁医药研究所、梧州医药研究所、桂林医药研究所等机构相继成立,对壮医药进行系统的发掘整理,出版了一系列著作,还进行了部分壮药剂型的改革.%By Zhuang materia medica,it refers to application of medicines under the instructions of medical theory of Zhuang ethnic group.By studying the pronunciation of the Zhuang language for the terms "zhu yu"," bai jiu",and "mi gu" included in the shah hai jing nan shan jing (The Classic of Southern Mountain in Classic of Seas and Mountains) carried out by the Zhuang scholar Qin Bao-lin,it was concluded that the Zhuang minority already applied medicines early in the pre-Qin period.Through extensive cultural communication in different regions in the Wei-Jin-Southern-Northern Dynasties,the medicinal experiences of the Zhuang ethnic group appeared in ancient literature.The antidotes in Zhou hou fang (Handbook of Prescriptions for Emergency),for instance,were mostly coming from the Southern Ridge area.Since the Sui-Tang Dynasties,many materia medica recorded in the herbal works and regional gazetteers,and Annals such as the Guangxi Annals,Gazetteer of Nanning County,and Gazetteer of Liuzhou County,Gazetteer of Binzhou County etc.,also carry medicines such as

  9. 坎地沙坦酯联合耳穴压豆对非杓型高血压病患者的疗效观察%Candesartan Cilexetil Combined With Auricular Acupuncture Point on Curative Effect of Non-Dipper Type Hypertension Patients

    Institute of Scientific and Technical Information of China (English)

    曲玉梅; 吴华慧

    2015-01-01

    目的:观察坎地沙坦酯联合耳穴压豆对非杓型高血压患者的血压影响。方法选取70例非杓型高血压患者随机分为治疗组和对照组,对照组夜间口服坎地沙坦酯;治疗组在口服坎地沙坦酯的同时加用耳穴压豆法。结果治疗后治疗能明显降低非杓型高血压患者的舒张压及收缩压,同时坎地沙坦酯联合耳穴压豆能促使非杓型高血压患者向杓型高血压转换。结论耳穴贴压法能明显降低非杓型高血压患者的血压,疗效优于对照组。%ObjectiveObservation of candesartan in conjunction of ear beans on non-Dipper type hypertension patients' blood pressure.Methods Select 70 non-Dipper type hypertension patients were randomly divided into treatment and control groups, controls the night oral candesartan ester treatment group at the time of oral administration of candesartan ester plus Auricular bean method.Results After treatment in the treatment of non-Dipper type hypertension patients can signiifcantly reduce the systolic blood pressure and diastolic blood pressure and candesartan combined Auricular beans can induce non-Dipper type hypertension patients switch to Dipper type hypertension. Conclusion Auricular acupoint method non-Dipper type hypertension patients can signiifcantly reduce blood pressure, than the control group.

  10. [Inheritance on and innovation of traditional Chinese medicine (TCM) flavor theory and TCM flavor standardization principle flavor theory in Compendium of Materia Medica].

    Science.gov (United States)

    Zhang, Wei; Zhang, Rui-xian; Li, Jian

    2015-12-01

    All previous literatures about Chinese herbal medicines show distinctive traditional Chinese medicine (TCM) flavors. Compendium of Materia Medica is an influential book in TCM history. The TCM flavor theory and flavor standardization principle in this book has important significance for modern TCM flavor standardization. Compendium of Materia Medica pays attention to the flavor theory, explain the relations between the flavor of medicine and its therapeutic effects by means of Neo-Confucianism of the Song and Ming Dynasties. However,the book has not reflected and further developed the systemic theory, which originated in the Jin and Yuan dynasty. In Compendium of Materia Medica , flavor are standardized just by tasting medicines, instead of deducing flavors. Therefore, medicine tasting should be adopted as the major method to standardize the flavor of medicine. PMID:27245045

  11. Development of Sustained Release "NanoFDC (Fixed Dose Combination" for Hypertension - An Experimental Study.

    Directory of Open Access Journals (Sweden)

    Anjuman Arora

    Full Text Available The present study was planned to formulate, characterize and evaluate the pharmacokinetics of a novel "NanoFDC" comprising three commonly prescribed anti-hypertensive drugs, hydrochlorothiazide (a diuretic, candesartan (ARB and amlodipine (a calcium channel blocker.The candidate drugs were loaded in Poly (DL-lactide-co-gycolide (PLGA by emulsion- diffusion-evaporation method. The formulations were evaluated for their size, morphology, drug loading and in vitro release individually. Single dose pharmacokinetic profiles of the nanoformulations alone and in combination, as a NanoFDC, were evaluated in Wistar rats.The candidate drugs encapsulated inside PLGA showed entrapment efficiencies ranging from 30%, 33.5% and 32% for hydrochlorothiazide, candesartan and amlodipine respectively. The nanoparticles ranged in size from 110 to 180 nm. In vitro release profile of the nanoformulation showed 100% release by day 6 in the physiological pH 7.4 set up with PBS (phosphate buffer saline and by day 4-5 in the intestinal pH 1.2 and 8.0 set up SGF (simulated gastric fluid and SIF (simulated intestinal fluid respectively. In pharmacokinetic analysis a sustained-release for 6 days and significant increase in the mean residence time (MRT, as compared to the respective free drugs was noted [MRT of amlodipine, hydrochlorothiazide and candesartan changed from 8.9 to 80.59 hours, 11 to 69.20 hours and 9 to 101.49 hours respectively].We have shown for the first time that encapsulating amlodipine, hydrochlorothiazide and candesartan into a single nanoformulation, to get the "NanoFDC (Fixed Dose Combination" is a feasible strategy which aims to decrease pill burden.

  12. [Good agricultural practice (GAP) of Chinese materia medica (CMM) for ten years: achievements, problems and proposals].

    Science.gov (United States)

    Guo, Lan-Ping; Zhang, Yan; Zhu, Shou-Dong; Wang, Gui-Hua; Wang, Xiu; Zhang, Xiao-Bo; Chen, Mei-Lan; He, Ya-Li; Han, Bang-Xing; Chen, Nai-Fu; Huang, Lu-Qi

    2014-04-01

    This paper aims to summarize the achievements during the implementation process of good agricultural practice (GAP) in Chinese Materia Medica (CMM), and on basis of analyzing the existing problems of GAP, to propose further implementation of GAP in TCM growing. Since the launch of GAP in CMM growing ten years ago, it has acquired great achievements, including: (1) The promulgation of a series of measures for the administration of the GAP approval in the CMM growing; (2) The expanded planting area of CMM; (3) The increased awareness of standardized CMM growing among farmers and enterprises; (4) The establishment of GAP implementation bases for CMM growing; (5) The improvement of theory and methodology for CMM growing; (6) The development of a large group of experts and scholars in GAP approval for CMM production. The problems existing in the production include: (1) A deep understanding of GAP and its certification is still needed; (2) The distribution of the certification base is not reasonable; (3) The geo-economics effect and the backward farming practices are thought to be the bottlenecks in the standardization of CMM growing and the scale production of CMM; (4) Low comparative effectiveness limits the development of the GAP; (5) The base of breeding improved variety is blank; (6) The immature of the cultivation technique lead to the risk of production process; (7) The degradation of soil microbial and the continuous cropping obstacle restrict the sustainable development of the GAP base. To further promote the health and orderly GAP in the CMM growing, the authors propose: (1) To change the mode of production; (2) To establish a sound standard system so as to ensure quality products for fair prices; (3) To fully consider the geo-economic culture and vigorously promote the definite cultivating of traditional Chinese medicinal materials; (4) To strengthen the transformation and generalization of basic researches and achievements, in order to provide technical

  13. [Investigation on pattern and methods of quality control for Chinese materia medica based on dao-di herbs and bioassay - bioassay for Coptis chinensis].

    Science.gov (United States)

    Yan, Dan; Xiao, Xiao-he

    2011-05-01

    Establishment of bioassay methods is the technical issues to be faced with in the bioassay of Chinese materia medica. Taking the bioassay of Coptis chinensis Franch. as an example, the establishment process and application of the bioassay methods (including bio-potency and bio-activity fingerprint) were explained from the aspects of methodology, principle of selection, experimental design, method confirmation and data analysis. The common technologies were extracted and formed with the above aspects, so as to provide technical support for constructing pattern and method of the quality control for Chinese materia medica based on the dao-di herbs and bioassay. PMID:21800546

  14. [Classes of crude drugs and its distribution of producing area in the attached illustrations in Ben cao tu jing (Illustrated Classic of Materia Medica)].

    Science.gov (United States)

    Xu, T; Peng, H S

    2016-03-01

    Ben cao tu jing (Illustrated Classic of Materia Medica) is the earliest extant atlas book of materia medica in China, with 933 attached drawings. Among them, the largest portion, amounting to 670, are herbaceous plants, mostly commonly used, with definite marks of the origin producing areas, distributed across 149 administrative divisions(prefectures and counties) of the Song Dynasty, most of them in Northern area which were distributed denser than those in Southern area. The densest ones were located in Southern Shanxi, Eastern Sichuan and Eastern Anhui. In the attached drawings, the frequency of highest occurrence appeared in this Classic are three prefectures, Chuzhou, Shizhou and Guangzhou. PMID:27255195

  15. Different Effects of Mahuang Decoction and Maxing Shigan Decoction on Animal Temperature Tropism and Correlation to Differences of Cold and Hot Nature of Chinese Materia Medica

    Institute of Scientific and Technical Information of China (English)

    WANG Jia-bo; ZHAO Yan-ling; ZHANG Xue-ru; ZHOU Can-ping; LIU Ta-si; ZHAO Hai-ping; REN Yong-shen; XIAO Xiao-he

    2010-01-01

    Objective To establish an objective method for evaluating the intrinsic characteristics between cold and hot nature of Chinese materia medica(CMM)through the different effects of Mahuang decoction(MHD)and Maxing Shigan decoction(MSD)on animal temperature tropism.Methods The equipment with cold/hot pads was used to investigate the variety ofthe temperature tropism between two groups of mice treated by MHD and MSD,respectively.Meanwhile,the activities ofadenosine triphosphatase(ATPase),superoxide dismutase,succinate dehydrogenase,and malondialdehyde were measured.Results After treated by MHD,the macroscopic behavioral index of remaining rate on warm pad(40 ℃)of mice decreasedsignificantly(P < 0.05),suggesting the enhancement of cold tropism,meanwhile,the internal indices of ATPase activity and oxygen consuming volume increased significantly(P < 0.05),suggesting the enhancement of energy metabolism.On theother hand,the above-mentioned indices in MSD group changed on the inverse way.Conclusion The relative drug natureof MHD and MSD revealed in this study is consistent with the theoretical prognostication or definition.It indicates that theinternal cold and hot nature of CMM could be reflected in ethological way on the changes of animal temperature tropismwhich might be internally regulated by body energy metabolism.

  16. 古代中药掺伪考%Textual research on adulteration of Chinese materia medica in ancient China

    Institute of Scientific and Technical Information of China (English)

    谢晋; 王德群

    2013-01-01

    By investigating the mainstream works of herbal classics of successive ages,it is found that adulteration of Chinese materia medica appeared early in ancient China.The main methods of adulteration was producing fraud medicines in the Northern-Southern Dynasties,fake medicines began to appear in the Tang Dynasty,and status of adulteration of Chinese materia medica ran unchecked since the Ming and Qing Dynasty.By statistics,there were 76 kinds of adulteration varieties before the Republican period.The main varieties were precious drugs,animal drugs and artifacts.Commonly methods used in the process included forging and adulterating,dealing with 11 kinds and 68 kinds respectively.Adulteration probably lead to the result of imposing the changes of the used medicinal parts of Herba Pogostemonis ; Radix Aconiti Lateralis prepared by adding salt,Radix Angelica Sinensis processed by wine,and Radix Astragalis seu Hedysaris processed with bee honey.However,the root cause of adulteration in Chinese materia medica was the dissociation of professional physician and pharmacist,resulting in the ignorance of medical practitioners became unable to recognize Chinese materia medica; and the immorality of medicinal merchants.Besides,rating the quality of materia medica based on its producing areas without differentiating the false from the genuine may also contribute to this result passively.%通过梳理历代主流本草发现,中药掺伪古已有之.南北朝时期以造作为主,唐代始见伪充,明清以后掺伪现象泛滥.据统计,民国以前本草著作记载的掺伪品种达76味,主要集中在贵重药、动物药和人工制品.常用掺伪手法有造作、伪充2种方式.其中涉及造作的中药有11味,而以假乱真的伪充品种高达68味.掺伪现象泛滥,迫使藿香药用部位改变,盐附子、酒制当归和蜜炙黄芪等炮制品的出现均可能与之有关.中药掺伪的根本原因是医药分家,医不识药,而商家职业操守淡漠;

  17. Using the Internet for Life Style Changes in Diet and Physical Activity: A Feasibility Study

    OpenAIRE

    Anhøj, Jacob; Jensen, Anne Holm

    2004-01-01

    Background LinkMedica-Heart is a novel Internet based program intended to support people who seek to improve their life style by means of changes in diet and physical activity. The program is currently under evaluation in a clinical study and the present study is a feasibility test of the LinkMedica-Heart Internet based program. Objective The aim of this study was to evaluate LinkMedica-Heart, an Internet based program we designed for support and maintenance of patient-led life style changes....

  18. Twenty years of society of medical informatics of b&h and the journal acta informatica medica.

    Science.gov (United States)

    Masic, Izet

    2012-03-01

    In 2012, Health/Medical informatics profession celebrates five jubilees in Bosnia and Herzegovina: a) Thirty five years from the introduction of the first automatic manipulation of data; b) Twenty five years from establishing Society for Medical Informatics BiH; c) Twenty years from establishing scientific and professional journal of the Society for Medical Informatics of Bosnia and Herzegovina "Acta Informatica Medica"; d) Twenty years from establishing first Cathdra for Medical Informatics on biomedical faculties in Bosnia and Herzegovina and e) Ten years from the introduction of "Distance learning" in medical curriculum. All of the five mentioned activities in the area of Medical informatics had special importance and gave appropriate contribution in the development of Health/Medical informatics in Bosnia And Herzegovina.

  19. Protective Effect of Candesartan on Podocyte Damage in Rats with Diabetic Nephropathy%坎地沙坦对糖尿病肾病大鼠足细胞保护作用的研究

    Institute of Scientific and Technical Information of China (English)

    李桂霞; 周静; 李秋月; 吕金雷; 李六生

    2011-01-01

    Objective To investigate the changes in podocyte ultrastructure and nephrin expression in rats with diabetic nephropathy(DN) ,and to observe the effect of candesartan on podocyte damage. Methods Thirty-six Sprague-Dawley rats were randomly divided into normal control group(group A),DN model group(group B),and candesartan treatment group (group C),with 12 rats in each group. DN was induced by intravenous injection of streptozotocin (30 mg · kg-1) and rats in group C were intragastricly given candesartan (5 mg · kg-1 · d-1) 1 week after induction of DN. Rats in group A and group B were given the same amount of normal saline. Blood glucose levels, body weight, 24-hour urinary protein excretion and endogenous creatinine clearance(Ccr) were measured at 4 and 7 weeks after treatment. Pathological changes in renal tissues were evaluated by HE staining and podocyte ultrastructure was observed using electron microscop. The expression of nephrin was detected by RT-PCR. Results Compared with group A, 24-hour urinary protein excretion and serum creatinine increased, Ccr decreased at 7 weeks, and nephrin expression reduced in group B(all P<0. 05). Compared with group B, 24-hour urinary protein excretion,serum creatinine,foot process width and glomerular basement membrane thickness decreased,and Ccr and nephrin expression increased in group C (all P<0.05). Conclusion DN patients have abnormal podocyte ultrastructure and nephrin expression. Candesartan can protect podocyte damage through up-regulating nephrin expression and improving podocyte ultrastructure.%目的 探讨糖尿病肾病(diabetic nephropathy,DN)大鼠足细胞超微结构及其相关分子nephrin表达的变化,以及坎地沙坦对其干预的影响,为DN的防治提供理论依据.方法 选择健康雄性SD大鼠36只,按随机数字表法分为A组(正常对照组)、B组(DN组)和C组(DN+坎地沙坦组),每组12只.B、C组尾静脉注射链脲佐菌素(30 mg·kg-1)制

  20. Effects of candesartan cilexetil and amlodipine orotate on receptor for advanced glycation end products expression in the aortic wall of Otsuka Long-Evans Tokushima Fatty (OETFF) type 2 diabetic rats.

    Science.gov (United States)

    Kang, Min-Kyu; Chung, Woo-Baek; Hong, Seul-Ki; Kim, Ok-Ran; Ihm, Sang-Hyun; Chang, Kiyuk; Seung, Ki-Bae

    2016-04-01

    The receptor for advanced glycation end products (RAGE) plays a key role in the development of vascular inflammation and acceleration of atherosclerosis in type 2 diabetes. We investigated the effect of candesartan cilexetil (CDRT) and amlodipine orotate (AMDP) on the expression of RAGE in the aortic walls of Otsuka Long-Evans Tokushima Fatty (OLETF) rats and AGE-treated endothelial cells. Twenty five-week-old OLETF rats were randomized to 8 week treatments consisting of CDRT (n = 8), AMDP (n = 8) or saline (control, n = 8). Immunohistochemical and dihydroethidine staining revealed reduced RAGE and reactive oxygen species (ROS) signals in rats treated with CDRT or AMDP compared with control rats. Both CDRT and AMDP suppressed the expression of p22phox and p47phox NADPH oxidase subunits. However, only CDRT significantly reduced expression of phosphorylated extracellular signal regulated kinase (pERK)1/2 in the aortic wall of OLETF rats. In addition, both drugs reduced RAGE expression and total and mitochondrial ROS production in the AGE-treated endothelial cells. Both ARBs and CCBs reduced RAGE expression in the aortic walls of OLETF rats, which was attributed to decreased ROS production through inhibition of NADPH oxidase. In addition, only CDRT reduced aortic expression of RAGE via suppression of the ERK1/2 pathway unlike AMDP. PMID:26960737

  1. Innovative Progress of the Separation & Purification Technologies in the Production of Chinese Materia Medica Preparation%中药制剂分离与纯化技术创新进展

    Institute of Scientific and Technical Information of China (English)

    陈秦娥; 梁金龙

    2012-01-01

    论述了深入研究中药制剂分离技术创新进展的意义,概述了固液分离技术在中药制剂中的重要作用,首次全面总结了14种制药分离与纯化主要设备的重大发展历程及创新特征,首次系统剖析了14种中药制剂提取分离与纯化高新技术原理特性和应用效果,首次研究阐明了现代中药制剂分离与纯化技术主要呈现的新老技术复合化、高技术超常化和新技术多样化三大发展趋势。%This paper discussed the significance of deep investigation on the innovative progress of separation & purification technologies in the production of Chinese materla medica preparation and summarized the important function of solid-liquid separation technology during the production process. Meanwhile, this study reviewed the momentous development course and innovative characteristics of the fourteen major separation & purification equipments, analyzed the principles and applies of separation & purification technologies systematically. It was clarified in the paper that compounding of old and new technologies, the practical application of high tech and the diversity of new tech were the three development trends on separation & purification technologies in the production of Chinese materia medica preparation nowadays.

  2. El ensayo Ars Medica de John Locke, y la influencia de sus ideas médicas sobre la filosofía empirista

    Directory of Open Access Journals (Sweden)

    Sánchez González, Miguel Ángel

    2014-06-01

    Full Text Available John Locke’s essay Ars medica of 1669, is presented, analyzed and translated into Spanish. This essay shows the medical problems that prompted Locke´s philosophy and provides essential clues to understanding the motives, aims and characteristics of the empiricist`s theory of knowledge. Ideas originated in medicine that profoundly influenced subsequent Locke`s works were: 1 Trust in the perfectibility of science and elucidation of the role that philosophical thinking could play. 2 Rejection of knowledge deduced from principles, hypotheses or maxims. 3 Reliance on a «plain historical method» for the production of knowledge, which tried to register facts descriptively, while abandoning the study of ultimate causes. 4 Use of a three-part classification of the sciences that enthrones semiotics, medical science par excellence, and defines it as a mere knowledge of the signs of things, that is not intended to discern either essences or substances. Locke, in his epistemology, applies to all scientific knowledge the medical theory of the signs of illnesses. He envisions all possible science as a mere descriptive knowledge of signs; and thinks that knowledge is probabilistic, analogous and pragmatic.Se presenta, analiza y traduce por primera vez al castellano, el ensayo Ars Medica escrito por John Locke en 1669. Este ensayo muestra los problemas médicos que dieron origen al conjunto de la filosofía de Locke; y ofrece claves esenciales para comprender los motivos, las metas y los rasgos de la teoría del conocimiento empirista. Ideas originariamente médicas que tuvieron una repercusión directa en la obra posterior de Locke fueron: 1 Confianza en la perfectibilidad de la ciencia y elucidación del papel que la reflexión filosófica podía desempeñar en ello. 2 Rechazo del conocimiento deducido de principios, hipótesis o máximas. 3 El método «histórico simple» para edificar el conocimiento; que intentaba registrar los hechos descriptivamente

  3. Antidepressant effects of Citrus medica L. var. sarcodactylis swingle from Sichuan province%川佛手提取物对小鼠的抗抑郁作用

    Institute of Scientific and Technical Information of China (English)

    芦红; 吴月霞; 杨丽嘉; 李继成; 张伟; 刘娜

    2011-01-01

    目的:研究川佛手提取物的抗抑郁作用.方法:采用水蒸气蒸馏法制备川佛手挥发油,采用回流提取法制备川佛手水提浸膏I、川佛手水提后醇提浸膏Ⅱ和Ⅲ、石油醚浸膏、乙酸乙酯浸膏和正丁醇浸膏,以生理盐水为空白对照,氟西汀为阳性对照药,采用小鼠强迫游泳实验和小鼠悬尾实验测定上述提取物实验4 min内对小鼠游泳和悬尾的不动时间的影响.结果:与空白对照组[(142.30±9.97)s]相比,阳性对照药氟西汀组、川佛手挥发油组、浸膏Ⅱ组、浸膏Ⅲ组小鼠游泳时不动时间均缩短[(80.80 ±6.33)、(77.20 ±10.73)、(107.40 ±12.28)和(78.30 ±9.33)s,F=11.080,P<0.001],而浸膏I组[(141.30 ±6.09)s]效果不明显.与空白对照组[(115.60 ±6.44)s]相比,氟西汀组、正丁醇浸膏组小鼠悬尾不动时间均缩短[(82.50 ±4.54)和(91.00 ±8.04)s,F=5.548,P=0.015].结论:川佛手具有一定的抗抑郁作用.%Aim: To study the antidepressant effects of the extracts of Citrus medica L. var. sarcodactylis from Sichuan province. Methods:Preparing the volatile oils of bergamot by steam distillation. Reflux extraction was used to prepared aqueous extract, ethanol extract after water extraction, petroleum ether extract, ethyl acetate extract and butanol extract of bergamot. Rat forced swimming tests (FST) and its tail suspension test(TST) were carried out to explore the effects of the above-mentioned extracts on swimming and tail suspension immobility time by choosing normal saline and fluoxetine as blank and positive control, respectively. Results:Compared with the blank control group[ ( 142.30 ± 9.97 ) s], fluoxetine,bergamot essential oil, extract Ⅱ and Ⅲ shortened mice swimming immobility time[ ( 80.80 ± 6.33 ), ( 77.20 ± 10.73 ),( 107.40 ± 12.28), and ( 78.30 ± 9.33 ) s; F = 1 1. 080, P < 0.001 ]. Further experiments showed that n-butanol extracts reduced mice swimming immobility time. Compared with the blank control

  4. 培哚普利与坎地沙坦对慢性心力衰竭患者ET-1、IL-6、MMP-9及左心室重塑的影响%Effects of perindopril and candesartan on left ventricular remodeling and serum ET-1,IL-6 and MMP-9 levels in patients with chronic heart failure

    Institute of Scientific and Technical Information of China (English)

    李莹; 宋耀明; 黄岚; 耿召华; 任可; 赵友光; 李佳

    2011-01-01

    Objective To evaluate the effects of perindopril and/or candesartan on the levels of endothelin-1 ( ET-1 ), interleukin-6 (IL-6) and matrix metal proteinase-9 (MMP-9) in serum and the left ventricular remodeling in patients with chronic heart failure (CHF). Methods Serum concentrations of ET-1, IL-6 and MMP-9 in normal controls (n = 26) and patients with CHF (n = 90 ), who were randomized into perindopril group (4 mg/d of perindopril), candesartan group (4 to 8 mg/d of candesartan) and combined group (4 mg/d of perindopril and 4 to 8 mg/d of candesartan) were measured before and after 8-week treatment. Left ventricular end-diastolic dimension (LVEDd) and left ventricular ejection fraction (LVEF) were measured by color Doppler echocardiography before and after the treatment. Results Before treatment, serum ET-1, IL-6 and MMP-9 levels in patients were significantly higher than those in normal subjects ( 110.31 ± 18.83 vs 48. 16 ±8.21, P<0. 01; 116.39 ±16.52 vs 62.47 ±10.78, P<0.01; 248.31 ±65.42 vs 74.63 ±9.87, P<0. 01;respectively). Serum ET-1, IL-6 and MMP-9 levels were positively correlated with LVEDd (r =0.436, P <0. 01 ), and negatively correlated with LVEF ( r = - 0. 481, P < 0. 01 ). After treatment, serum ET-1, IL-6 and MMP-9 levels and LVEDd in the combined group were significantly lower than those in the perindopril group and the candesartan group (63.52 ± 17.17 ng/ml vs 79.24 ± 12.81 ng/ml vs 75.47 ± 16. 23 ng/ml,P < 0.05; 82.58 ± 9.47 ng/L vs 94.16 ± 11.43 ng/L vs 91.46 ± 10.27 ng/L, P < 0. 05; 183.52 ± 30.66 pg/ml vs 208.16 ± 36.62 pg/ml vs 205.91 ± 32.28 pg/ml, P < 0.05; 50.51 ± 6.38 vs 55.73 ± 7.85 vs 55.16 ± 8.19,P < 0.05; respectively). On the contrary, LVEF in the combined group was significantly higher than that in the perindopril group and the candesartan group (49.21 ± 8.59 vs 44.87 ±4.73 vs 46.17 ±6.36, P <0. 05 ).However, no such difference was noted between the perindopril group and the

  5. Određivanje sastava hlapljivih tvari i flavonoida u kori citrona (Citrus medica L. var. Corsican), za procjenu kakvoće likera

    OpenAIRE

    Venturini, Nicolas; Barboni, Toussaint; Curk, Franck; Costa, Jean; Paolini, Julien

    2014-01-01

    U radu je ispitan sastav hlapljivih tvari i flavonoida u kori citrona (Citrus medica L. var. Corsican) uzgojenog na Korzici, različitog stupnja zrelosti izračunatog pomoću sume aktivnih temperatura. Razlike u stupnju razvoja plodova kvantitativno su određene plinskom kromatografijom, plinskom kromatografijom u kombinaciji s masenom spektrometrijom, te tekućinskom kromatografijom praćenom tandemskom masenom spektrometrijom. Identificirano je 30 hlapljivih komponenata eteričnog ulja dobivenog i...

  6. A medicação prescrita na internação hospitalar: o conhecimento do cliente

    Directory of Open Access Journals (Sweden)

    Ana Carolina Guidorizzi Zanetti

    2003-12-01

    Full Text Available Erros no processo de administração de medicamentos são preocupações de enfermeiros e a sua ocorrência pode ser minimizada com a orientação do cliente quanto à terapia medicamentosa. Este estudo descritivo, teve como objetivo identificar o grau de informação de clientes hospitalizados, acerca dos medicamentos que lhes são prescritos. A metodologia utilizada foi a exploratória-descritiva. Foram entrevistados 76 clientes adultos, hospitalizados, entre 18 a 60 anos, sendo 69,7% do sexo feminino. Destacou-se dentre outros, que 28% não apresentavam conhecimento acerca do nome do primeiro medicamento prescrito e 55% não souberam referir a dosagem. Detectou-se um número razoável de clientes que desconheciam a medicação prescrita ou tinham conhecimento incorreto. Faz-se necessário a conscientização dos profissionais de enfermagem quanto à importância da orientação ao cliente acerca dos medicamentos durante a internação.

  7. Clinical and radiographic comparison of various medicaments used for pulpotomy in primary molars: A randomized clinical trial

    Science.gov (United States)

    Goyal, Prachi; Pandit, I. K.; Gugnani, Neeraj; Gupta, Monica; Goel, Richa; Gambhir, Ramandeep Singh

    2016-01-01

    Objective: To evaluate and compare the efficacy of ferric sulfate, glutaraldehyde, and mineral trioxide aggregate (MTA) as pulpotomy medicaments in primary molars. Materials and Methods: This was a perspective randomized clinical trial. A total of 90 molars from 42 children aged 4–8 years were selected for pulpotomy procedure. Teeth were randomly divided into three equal groups of 30 teeth each. Teeth in Group I were intended to be treated with ferric sulfate, Group II were intended to be treated with buffered glutaraldehyde and Group III with MTA. All the molars were evaluated clinically at 24 h and both clinically and radio graphically at 1, 3, and 6 months. The observations were statistically analyzed using Chi-square test and Fisher's exact test. Results: After 1 month, there was no clinical finding observed in all the three groups. At 3 months postoperative evaluation, 13.3% of teeth in Group I and 12.5% of teeth in Group II had mobility. At 6 months interval, pain and sinus formation each was noted in 9.1% of primary teeth in Group I while periodontal ligament widening was reported in 66.7% of teeth in Group I and 85.7% of teeth in Group II. Conclusion: MTA exhibited overall best results as pulpotomy agent for primary molars followed by 15.5% ferric sulfate, whereas 2% buffered glutaraldehyde was found to be least effective as a pulpotomy agent. PMID:27403046

  8. In vitro effect of intracanal medicaments on strict anaerobes by means of the broth dilution method Efeito in vitro de medicações intracanal sobre anaeróbios estritos pelo método de diluição em caldo

    Directory of Open Access Journals (Sweden)

    Odila Pereira da Silva ROSA

    2002-03-01

    Full Text Available The determination of bacterial susceptibility to intracanal medicaments is a necessity. Nevertheless, few studies utilize the proper methodology to carry out that evaluation with anaerobes. In this study, the steps of a broth dilution method, carried out in microplates (microdilution and tubes (macrodilution, to test the effect of traditional intracanal medicaments on anaerobic bacteria are described. The results are presented as values of minimal inhibitory and bactericidal concentrations (MIC and MBC. Standardized inocula of the anaerobic bacteria Prevotella nigrescens (ATCC 33563, Fusobacterium nucleatum (ATCC 25586 and Clostridium perfringens (ATCC 13124, in reinforced Clostridium medium (RCM and supplemented Brucella broth, were submitted to different concentrations of calcium hydroxide, chlorhexidine digluconate, camphorated paramonochlorophenol and formocresol solutions. The drugs were diluted in the same culture broths, in microplates and tubes, and were then incubated in anaerobiosis jars at 37ºC for 48 or 96 hours. The determination of MICs was carried out through visual and spectrophotometric readings, and the determination of MBCs, through the plating of aliquots on RCM-blood agar. For that kind of study, the macromethod with spectrophotometric reading should be the natural choice. MICs and MBCs obtained with the macromethod were compatible with the known clinical performance of the studied medications, and the values varied according to the bacteria and culture media employed. RCM was the most effective medium and C. perfringens, the most resistant microorganism.A determinação da suscetibilidade bacteriana aos medicamentos intracanal é uma necessidade, mas são poucos os estudos que utilizam metodologia própria para anaeróbios estritos nessa avaliação. Neste estudo, são descritos os passos de um método de diluição em caldo, feito em microplacas (microdiluição e em tubo (macrodiluição, para testar a ação de

  9. Dental pulp response to collagen and pulpotec cement as pulpotomy agents in primary dentition: A histological study

    OpenAIRE

    Pranitha Kakarla; Jogendra Sai Sankar Avula; George Manojkumar Mellela; Sujatha Bandi; Sampath Anche

    2013-01-01

    Introduction: As the search for a better biocompatible medicament is on, aim of the present study was to evaluate the pulpal response to collagen particles impregnated in antibiotics (Biofil TM -AB) and new commercially available cement (Pulpotec) that can be used as pulpal medicament. Materials and Methods: Total sample of 40 teeth from 20 children in the age group of 7-10 years which are noncarious having bilateral retained primary teeth were enrolled for the study. Nine teeth each were...

  10. In vitro evaluation of the effects of the interaction between irrigating solutions, intracanal medication and Er:YAG laser in dentin permeability of the endodontic system Estudo in vitro dos efeitos da interação de substâncias irrigantes, medicação intracanal e laser Er:YAG na permeabilidade dentinária do sistema endodôntico

    Directory of Open Access Journals (Sweden)

    Denise Pontes Raldi

    2003-09-01

    Full Text Available The purpose of this study was to evaluate in vitro the effects of different associations between irrigating solutions (EDTA-T and citric acid, intracanal medicament (NDP, and Er:YAG laser irradiation on dentin permeability. Fifty-one extracted single-rooted teeth were instrumented and divided into seven groups. Groups GI and GII had final irrigation with a demineralizing solution only (EDTA-T and citric acid, respectively. Groups GIII and GIV had final irrigation with EDTA-T and citric acid, respectively, plus an association of irrigating solution and Er:YAG laser. Groups GV and GVI had final irrigation with EDTA-T and citric acid, respectively, plus an association of intracanal medication and Er:YAG laser. Group GVII (control group had final irrigation with distilled water. All root canals were filled with NDP associated with rhodamine B dye. After the experimental period, the samples were transversely cut into six 2.0 mm thick slices for subsequent reading using the ImageLab software. Analysis of the results allowed us to conclude that there were statistically significant differences (p Este experimento teve como objetivo avaliar in vitro os efeitos da interação entre soluções irrigantes desmineralizadoras (EDTA-T e ácido cítrico, medicação intracanal (NDP e laser Er:YAG na permeabilidade dentinária. Foram utilizados 51 dentes unirradiculares extraídos que, após o preparo químico-cirúrgico, foram divididos em sete grupos experimentais: grupos I e II - irrigação final com solução de EDTA-T e ácido cítrico, respectivamente; grupos III e IV - irrigação final com EDTA-T e ácido cítrico, respectivamente, mais a associação entre solução irrigante e laser Er:YAG; grupos V e VI - irrigação final com EDTA-T e ácido cítrico, respectivamente, mais a associação entre medicação intracanal e laser Er:YAG, e grupo VII (controle - irrigação final com água destilada. Os canais radiculares foram preenchidos com o corante

  11. Consideraciones medicas y psicologicas en ninos de 5 y 6 anos de 6 guarderias infantiles

    Science.gov (United States)

    DeSilva, Milagros Guerra; DeViloria, Carmen Leon

    1975-01-01

    This study assessed the effect of attendance at state kindergartens of a group of 181 five- and six-year-olds from low socioeconomic backgrounds. The effects of a supplemental nutritional program as well as the children's attitudes toward attendance were considered. (MS)

  12. Analisis Komponen Kimia Minyak Atsiri Kulit Jeruk Telur Buaya (Citrus medica L.) Secara GC-MS dan Uji Antioksidan Dengan Metode DPPH

    OpenAIRE

    Silalahi, Grignard Natanael

    2015-01-01

    Essential oils of the rind of jeruk telur buaya (Citrus medica L) has been isolated with hydrodestillation method using Stahl. It hydrodestilled for ± 4-5 hours to produce essential oil 0.3064% (w/w). The chemical components of essential oil of rind of jeruk telur buaya were analyzed by GC-MS showed there are 14 compounds in which the main components are 1-limonene (70,46%). Antioxidant activity test has been done with DPPH (2,2-diphenyl-1-picryl-hydrazil) method with IC50 values 873.39 mg/L.

  13. Antioxidant mix: A novel pulpotomy medicament: A scanning electron microscopy evaluation

    Directory of Open Access Journals (Sweden)

    M Ajay Reddy

    2014-01-01

    Full Text Available Aim: This study aims to evaluate the clinical, radiographic, and histological success rate of antioxidant mix as a new pulpotomy agent for primary teeth. Settings and Design: Commercially available antioxidants, namely Antioxidants plus trace elements (OXIn-Xt tm , India were used. Materials and Methods: This prospective study was carried out on 36 primary molar teeth in 32 children, with age that ranged from 6 to 9 years. Regular conventional pulpotomy procedure followed by placement of antioxidant mix over the radicular orifice was done. Recall was scheduled for 3, 6, and 9 months, respectively, after treatment. Results: Thirty-six pulpotomized primary molars were available for follow-up evaluations. Scanning electron microscopy analysis of samples showing convex shaped hard tissue barrier formation may be proof of the role of antioxidant material in localization and direction and morphology of the hard tissue barrier. One tooth which presented with pain was assessed as unsuccessful. Conclusion: Quite promising clinical, radiographic, and histological results of antioxidants in the present study shows their potential to be an ideal pulpotomy agent.

  14. Reconstruction algorithm medical imaging DRR; Algoritmo de construccion de imagenes medicas DRR

    Energy Technology Data Exchange (ETDEWEB)

    Estrada Espinosa, J. C.

    2013-07-01

    The method of reconstruction for digital radiographic Imaging (DRR), is based on two orthogonal images, on the dorsal and lateral decubitus position of the simulation. DRR images are reconstructed with an algorithm that simulates running a conventional X-ray, a single rendition team, beam emitted is not divergent, in this case, the rays are considered to be parallel in the image reconstruction DRR, for this purpose, it is necessary to use all the values of the units (HU) hounsfield of each voxel in all axial cuts that form the study TC, finally obtaining the reconstructed image DRR performing a transformation from 3D to 2D. (Author)

  15. Reloj citoplasmatico y desarrollo embrionario temprano: un modelo con futuras aplicaciones medicas y comerciales.

    Directory of Open Access Journals (Sweden)

    Omar Camargo

    2000-01-01

    Full Text Available The meiotic cycle in mammals begins in the fetal ovary, proceeds to state diplonete prophase of the first, and stops shortly before birth in a similar G2.La reset phase meiosis, which occurs immediately before ovulation, it represents the transition between the G2 and M phases of the cell cycle. A ovulated and fertilized see the oocyte is activated, a phenomenon that enables him to start the clivage which consists of rapid changes of interface states and mitosis.Se has suggested that a "clock computer" controls the post-zygotic clivage under that these divisions are relatively fast, synchronous and not depend on the growth celular.Aunque have discovered several components of this clock, the elements that determine their ciclidad not been identified .The watch it, it is characterized by the activity of the factor promoter M phase (FPM, a cyclin-dependent kinase, which when activated induces the cell to .In mitosis other hand has been found to increase newspapers concentration cytosolic free calcium ([Ca ++] i contributes to the regulation of cell cycles. Although the degree of regulation exercised by these oscillations of [Ca ++] i is not known with certainty, it has been suggested that the mechanism that controls them is a fundamental component of the big clock computer. Here we explore the possible interactions that may exist between Ca ++ and FPM, how are you regulate cell cycles during early embryonic development (post-zygotic] and medical and commercial applications have been derived from the study.

  16. Analysis of medical exposures in digital mammography; Analise das exposicoes medicas em mamografia digital

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Sergio R., E-mail: oliveirasr@fiocruz.br [Escola Politecnica de Saude Joaquim Venancio (EPSJV/FIOCRUZ), Rio de Janeiro, RJ (Brazil); Mantuano, Natalia O.; Albrecht, Afonso S., E-mail: nataliamantuano@gmail.com, E-mail: afonsofismed@gmail.com [Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ (Brazil). Instituto de Fisica; Flor, Leonardo S., E-mail: leonardo.flor@hsvp.org.br [Hospital Sao Vicente de Paulo (HSVP), Rio de Janeiro, RJ (Brazil)

    2014-07-01

    Currently, the use of digital mammography in the early diagnosis of breast cancer is increasingly common due to the production of high definition image that allows to detect subtle changes in breast images profiles. However it is necessary to be an improvement of the technique used since some devices offer minimization parameters of entrance dose to the skin. Thus, this study seeks to examine how the qualification of technical professionals in radiology interferes with the use of the techniques applied in mammography. For this, survey was carried out in a hospital in the city of Rio de Janeiro, which evaluated the scans of 1190 patients undergoing routine mammography (It is considered routinely the 4 basic exhibitions: with 2 flow skull and 2 medium oblique side, excluding repeats and supplements) in 2013. The medical exposures analyzed obtained from a single full digital equipment, model Senographe DS were compared with three different procedures performed by professionals in mammography techniques. The images were classified according to exposure techniques available in the equipment: Standard (STD), contrast (CNT) and dose (dose), and to be selected as breast density of the patient. Comparing the variation of the radiographic technique in relation to the professional who made the exhibition, what is observed is that the professional B presented the best conduct in relation to radiological protection, because she considered breast density in the choice of technical equipment parameter. The professional A, which is newly formed, and C, which has more service time, almost did not perform variations in the pattern of exposure, even for different breast densities. Thus, we can conclude that there is a need to update the professionals so that the tools available of dose limitation and mamas variability to digital mammography are efficiently employed in the service routine and thus meet the requirements of current legislation.

  17. 中药“十八反”基层医院应用现状调查%Research on Application Status of Eighteen Incompatible Medicaments in Primary Hospital

    Institute of Scientific and Technical Information of China (English)

    于大猛; 瞿融; 范欣生; 杨杰

    2012-01-01

    To investigate application status of eighteen incompatible medicaments in primary hospital. We searched 78 ,238 recipes originated from a county hospital of traditional Chinese medicine and 9 health clinics in towns and townships between 2008 and 2011. All recipes containing eighteen incompatible medicaments were statistically analyzed. Two handred and fifty-five recipes containing eighteen incompatible medicaments were found. There were 198 recipes in aconite group and 57 recipes in radix glycyrrhizae group. No recipe in veratrinigri group was found. Radix Aooniti Lateralis preparata in combination with Rhizoma Pinelliae was the most common formula of all eighteen incompatible medicaments. Most clinicians hold a negative attitude to application of eighteen incompatible medicaments. Application of eighteen incompatible medicaments in primary hospital is objectively existent, and it is not absolutely contraindicated.%调查基层医院应用中药十八反的现状.检索某县级中医院及9所乡镇卫生院2008-2011年的处方78 238首,对其中含十八反药对的处方进行统计分析.结果表明共发现含十八反药对的处方255首,其中乌头组198首,甘草组57首,藜芦组0首,以附子半夏应用最多,并出现多组反药同用的情况,临床医生对十八反问题多持回避态度.中药十八反在基层医院的应用是客观存在的,并非绝对的禁总.

  18. Interações farmacológicas entre medicações clínicas e psiquiátricas Drug interactions among clinical and psychiatric drugs

    OpenAIRE

    Marco Antonio Marcolin; Maria da Graça Cantarelli; Manoel Garcia Junior

    2004-01-01

    INTRODUÇÃO/JUSTIFICATIVA: Estudos apontam as reações adversas graves (ADR) como uma das seis causas de morte em pacientes hospitalizados nos EUA, sendo que das ADR, a mais freqüente inclui as Interações Medicamentosas (IM). MÉTODOS: foram cruzadas 20 medicações mais utilizadas em andares clínicos do Hospital Universitário São Lucas da PUCRS com 14 medicações mais utilizadas no Ambulatório de Depressão do HSL-PUCRS; pesquisou-se no Medline e Lilacs a partir de 1990. RESULTADOS: foram encontrad...

  19. 植物药对他克莫司血药浓度的影响%Influence of planta medica on the blood concentration of tacrolimus

    Institute of Scientific and Technical Information of China (English)

    逄晓云; 沈金芳

    2009-01-01

    他克莫司是一种器官移植患者广泛使用的免疫抑制剂,大大提高了患者的生活质量和生存率.目前,越来越多的学者关注到西药和他克莫司的相互作用,然而,关于植物药与其相互作用的系统研究很少.本文就植物药与他克莫司的相互作用进行探讨.%Tacrolimus is an widely used immuno-suppressant in organ transplant patients for anti-rejection , and the quality of life and survival rate are greatly enhanced. At present, a growing number of scholars concerned with drug interactions of Western medicine and tacrolimus. However, the impact of planta medica on it was rarely systematically overviewed. This article explored the interaction of planta medica and tacrolimus.

  20. Lupus induced by medicaments

    International Nuclear Information System (INIS)

    We describe a 55 years old female patient who consulted by fever syndrome, artralgias and the presence of high tittles positives antinuclear antibodies. She had arterial hypertension in treatment with captopril. We suspected the clinical diagnoses of drug-induced lupus; the withdraw of captopril was associated with the remission of the clinical and laboratory manifestations

  1. Uso da medicação homeopática no tratamento da ceratoconjuntivite primaveril: resultados iniciais Treatment of vernal keratoconjunctivitis with homeopathic medicine: a preliminary report

    Directory of Open Access Journals (Sweden)

    Cláudio Maciel de Sena

    2003-01-01

    Full Text Available OBJETIVO: Apresentar os primeiros resultados do uso da Homeopatia entre os pacientes com conjuntivite primaveril, avaliados no Serviço de Córnea e Doenças Externas do Hospital São Geraldo. MÉTODOS: Foram incluídos no presente estudo 13 pacientes apresentando ceratoconjuntivite primaveril, examinados no período de janeiro de 1998 a dezembro de 1999. A idade média dos pacientes foi de 9,5 anos, sendo nove do sexo masculino e quatro do sexo feminino. Todos os pacientes já haviam feito uso de corticóide tópico antes da sua inclusão no estudo. Antes de iniciar o tratamento homeopático, todos os pacientes foram examinados por um dos autores, sendo acompanhados pelo mesmo médico, mensalmente até os seis meses e depois trimestralmente até completar um ano do tratamento homeopático. O tratamento homeopático foi realizado por meio de uma dose única, via oral, baseando-se na totalidade sintomática do paciente. RESULTADOS: A porcentagem de melhora dos sinais e sintomas, entre os pacientes, foi de: lacrimejamento e dor ocular 100%; secreção ocular 92%; sensação de corpo estranho 86%; prurido e fotofobia 84%; relatavam diminuição ou ausência do desconforto que a ceratoconjuntivite primaveril provocava nas suas atividades diárias 84%; nódulos de Trantas 62,5%; hiperemia conjuntival 61%; erosões epiteliais 58% e hipertrofia da papila tarsal 8%. CONCLUSÃO: Este estudo sugere efeito benéfico da medicação homeopática no tratamento da ceratoconjuntivite primaveril, com melhora dos sinais e sintomas da doença. Sugere-se a realização de estudo duplo-cego, com maior número de casos, para a confirmação desses resultados.PURPOSE: To present a preliminary report of homeopathic medicine in the treatment of vernal keratoconjunctivitis, at the Cornea service, of the São Geraldo Hospital. METHODS: Thirteen patients with vernal keratoconjunctivitis, examined from January 1998 to December 1999, were included in the present study

  2. Erros de medicação: análise do conhecimento da equipe de enfermagem de uma instituição hospitalar Errores de medición: análisis del conocimiento del equipo de enfermería de una institución hospitalaria Measurement errors: analysis of the nursing staff's knowledge in a hospital

    Directory of Open Access Journals (Sweden)

    Paulo Celso Prado Telles Filho

    2011-09-01

    Full Text Available Objetivou-se verificar e analisar junto à equipe de enfermagem o conhecimento sobre em que consiste um erro de medicação, sua necessidade de notificação e o conteúdo da mesma. Trata-se de pesquisa de caráter quantitativo descritivo, desenvolvida em uma instituição hospitalar, da qual fizeram parte 72 profissionais. Em relação à definição de erros de medicação, constatou-se que 49 (68% possuem conceito semelhante ao adotado nesse estudo. Quanto à necessidade de notificação, 67 (93% afirmaram sua necessidade. Referente ao conteúdo da notificação, 63 (85% possuem conceito semelhante ao adotado no estudo. Evidencia-se a necessidade de aprofundamento em relação aos aspectos referentes aos erros de medicação.El objetivo fue verificar y analizar con el equipo de enfermería el conocimiento sobre en qué consiste un error de medición, la necesidad de ser notificado y lo que debe constar en dicha notificación. Consiste en una investigación cuantitativa descriptiva, desarrollada en una institución hospitalaria, de la cual formaron parte 72 personas. En relación a la definición de errores de medición, 49(68% tienen concepto semejante al adoptado en este estudio. En cuanto a la necesidad de notificación, 67(93% afirmaron que existe dicha necesidad. En relación al contenido de la notificación, 63(85% tienen concepto semejante al adoptado en este estudio. Fue evidente la necesidad de profundizar en relación a los errores de medicación.The aim of this study was to determine and discuss with the nursing staff their knowledge about what represents a medication error, the need to notify such an error and what would be necessary to put in these notifications. This is a descriptive quantitative study, carried out in a hospital, of which 72 professionals took part. Regarding the definition of medication errors, we found that 49 (68% share the concept adopted in this study. Regarding the need of notification, 67 (93% declared

  3. Effectiveness of four different techniques in removing intracanal medicament from the root canals: An in vitro study

    OpenAIRE

    A C Bhuyan; Mukut Seal; Kartik Pendharkar

    2015-01-01

    Aim: To evaluate the effectiveness of different techniques in removing calcium hydroxide (Ca(OH) 2 ) from the root canal. Materials and Methods: Twenty-four freshly extracted mandibular premolars were instrumented using ProTaper rotary instruments. The teeth were longitudinally split into two halves, cleaned of debris. The two halves were then reassembled and filled with Ca(OH) 2 and were divided into four groups. In Group I, the teeth were irrigated with 5 mL of 2.5% sodium hypochlorite (NaO...

  4. Practice and thought of MOOC for Chinese materia medica%中药学MOOC课程的制作实践与思考

    Institute of Scientific and Technical Information of China (English)

    刘四军; 刘步平; 吴庆光

    2015-01-01

    目的:大规模开放在线课程(Massive Open Online Course,MOOC)近年来受到国际教育界的高度关注,对高等教育正在产生着广泛而深远的影响。以传统医学的基础学科中药学作为切入点,对中药学MOOC制作进行实践与探索。方法通过中药学授课老师团队的研讨,在对整个中药学知识点进行梳理、模块化、单元化的基础上,组建MOOC拍摄团队,对课程进行视频制作、发表、互动以及管理,并总结了制作过程中遇到的问题。结果在团队合作的基础上,开发了中药学MOOC课程,从而改进互动方式和课程,使教学更有效。结论MOOC可能是未来教育资源建设的聚焦点,制作优质的MOOC资源是首当其冲的问题。%Objective Massive open online course (MOOC) has received close attention in the international educational world in recent years, and has brought about wide and far-reaching influence on higher education. This paper explored and practiced production of MOOC by taking Chinese materia medica as an entry point. Methods Research was conducted by Chinese materia medica teaching team to find out knowledge points for teaching in different modules and units. Shooting team was also organized for video producing, issuing, interaction and management. Problems in the course of production were summarized. Results Online course of Chinese materia medica might contribute to interactive mode of teaching and result in more effective teaching. Conclusion MOOC can be the focus of the future construction of educational resources. Production of high-quality MOOC resources is the most important issue to be considered.

  5. Fatores preditores e conseqüências clínicas do uso de múltiplas medicações entre idosos atendidos em um serviço ambulatorial de saúde mental

    Directory of Open Access Journals (Sweden)

    Almeida Osvaldo P.

    1999-01-01

    Full Text Available OBJETIVO: Investigar o padrão de uso de medicamentos, polifarmácia e uso impróprio de medicações entre indivíduos com 60 anos ou mais atendidos no serviço ambulatorial de saúde mental da Santa Casa de São Paulo, Brasil. MÉTODOS: Cento e oitenta e quatro pacientes atendidos de forma consecutiva foram avaliados sistematicamente quanto à dosagem e tempo de utilização de medicamentos na semana que antecedeu a consulta médica. A presença de sintomas físicos e psicológicos foi avaliada com a escala Saftee-Up simplificada. O uso impróprio de medicamentos foi avaliado através dos critérios de Stuck modificado. RESULTADOS: O número médio de medicações consumidas por paciente foi de 2,46 - 41,3% dos entrevistados utilizavam três ou mais medicamentos e 10,9% utilizavam cinco ou mais medicações por dia. Antidepressivos (42,4%, drogas anti-hipertensivas (32,6% e benzodiazepínicos (21,2% eram as medicações mais freqüentemente utilizadas. Pacientes utilizando três ou mais medicações apresentavam escores mais elevados na escala Saftee-Up (p=0,007. Análise de regressão logística indicou que os escores da Saftee-Up eram influenciados de forma significativa pelo número de diagnósticos clínicos (OR=1,85, p=0,030, mas não pela idade (OR=0,99, p=0,732, sexo (OR=0,67, p=0,317, número de diagnósticos psiquiátricos (OR=0,77, p=0,533 ou de medicações (OR=1,18, p=0,258. Trinta e quatro idosos (18,5% vinham utilizando pelo menos uma medicação considerada imprópria. CONCLUSÕES: É importante que os psiquiatras estejam cientes das diretrizes internacionais para prescrição de drogas e participem ativamente para reduzir os riscos associados à polifarmácia e uso impróprio de medicamentos em idosos.

  6. A pré-medicação com midazolam antes de secção cesariana não tem efeitos adversos no neonato

    Directory of Open Access Journals (Sweden)

    Ahmet Can Senel

    2014-01-01

    Full Text Available Como todos os pacientes cirúrgicos, pacientes obstétricas também sentem estresse e ansieda de operatórios. Isso pode ser prevenido se forem passadas à paciente informações detalhadas sobre sua operação e se forem administrados medicamentos farmacológicos pré-operatórios. Devido aos efeitos depressivos dos sedativos nos neonatos, os medicamentos farmacológicos são omitidos, especialmente em pacientes obstétricas. A literatura contém poucos estudos concernentes ao uso de midazolam no pré-operatório em pacientes de secção cesariana (C/S. Nosso objetivo nesse estudo foi ajudar nossas pacientes passando por cirurgia C/S. Um grupo agendado para C/S eletiva recebeu midazolam 0,025 mg kg−1 por via intraveno sa; o outro grupo recebeu salina. A ansiedade materna foi avaliada com o uso dos escores da Amsterdam Preoperative Anxiety and Information Scale (APAIS (Escala de Ansiedade e Informação Pré-operatória de Amsterdam, e os neonatos foram avaliados por Apgar e pelo instrumento Neonatal Neurologic and Adaptive Capacity Score (NACS (Escore Neurológico e de Capacidade Adaptativa do Neonato. Em conclusão, os pacientes pré-medicados com midazolam 0,025 mg kg−1 medicação tiveram escores de ansiedade significativamente baixos, sem qualquer efeito adverso nos neonatos. Portanto, midazolam pode, com segurança, ser utilizado como agente de pré-medicação na cirurgia C/S.

  7. Funcionamento intelectual em pacientes pediátricos com epilepsia: comparação de crianças controladas com medicação, não controladas com medicação e controladas com cirurgia Intellectual functioning in pediatric patients with epilepsy: a comparison of medically controlled, medically uncontrolled and surgically controlled children

    Directory of Open Access Journals (Sweden)

    Cecília Souza-Oliveira

    2010-10-01

    Full Text Available OBJETIVO: Comparar o quociente intelectual (QI em três grupos de crianças com epilepsia: 1 controlados com medicação, 2 não controlados com medicação e 3 controlados com cirurgia. MÉTODOS: Noventa e oito pacientes pediátricos, com idades entre 6 e 12 anos, foram selecionados de dezembro de 2007 a julho de 2008. A Escala de Inteligência Wechsler para Crianças - terceira edição (WISC-III foi utilizada para a avaliação neuropsicológica dos pacientes. Os resultados foram relacionados com a síndrome epiléptica, a etiologia da epilepsia, o tratamento medicamentoso, a idade do paciente no início da epilepsia e a duração da epilepsia. RESULTADOS: Os escores da WISC foram significativamente melhores no grupo controlado com medicação quando comparados aos do grupo não controlado com medicação. O grupo controlado com medicação obteve um desempenho significativamente melhor na maioria dos subtestes da WISC quando comparado ao grupo não controlado com medicação: vocabulário, aritmética, compreensão, memória de dígitos, completar figuras, arranjo de figuras e cubos. Um número significativamente maior de pacientes com epilepsia idiopática e uso de monoterapia foi observado no grupo controlado com medicação quando comparado ao grupo não controlado. O grupo controlado com cirurgia não apresentou diferença significativa no desempenho do QI quando comparado ao grupo controlado com medicação. CONCLUSÕES: As crianças com um bom controle de crises tiveram um melhor desempenho no QI geral, verbal e de execução quando comparadas às crianças com epilepsia refratária. Esses resultados podem ser influenciados por fatores clínicos como o uso de monoterapia, o tipo de droga antiepiléptica utilizada, a síndrome epiléptica e a etiologia da epilepsia. A cirurgia de epilepsia pode causar um impacto positivo no desempenho cognitivo das crianças que ficaram livres de crises após o procedimento cirúrgico.OBJECTIVE: To

  8. Investigation on Detection of Aflatoxins in Chinese Materia Medica and Pharmaceutical Intermediates Microbiological Contaminated by Immunoaffinity Column Clean-up Combined with Post-column Derivatization%免疫亲和柱净化HPLC柱后光化学衍生化法检测中药及染菌中药制剂中间体的黄曲霉毒素

    Institute of Scientific and Technical Information of China (English)

    胡一晨; 万丽; 范成杰; 吕维; 杨芳; 吉琅

    2012-01-01

    Objective; To establish a method to determine aflatoxins B,, B2, G1, G2 in Chinese Materia Medica and pharmaceutical intermediates microbiological contaminated by immunoaffinity column clean-up combined with post-column derivatization and HPLC-FD detection. Method: Using immunoaffinity column cleanup combined with post-column derivatization, the analytical method to detect aflatoxins B1 , B2, G,, G2 was established firstly, and then 14 kind of Chinese Materia Medica and pharmaceutical intermediates microbiological contaminated was detected respectively. Result: The method with the great linear concentration range of 0. 15-6.0 ng-mL-1 for aflatoxins G2, B2, and 0.5-20.0 ug·L-1'for G,, B, respectively, was stable and accurate. As a result, aflatoxins B,was detected in Chuanxiong Rhizoma and Platycladi Semen in the 14 kind of Chinese Materia Medica, while there were none of aflatoxins in the pharmaceutical intermediates made by Chuanxiong Rhizoma. Conclusion: The method established in this study was specific and accurate for the detection of aflatoxins in Chinese Materia Medica and pharmaceutical intermediates.%目的:采用免疫亲和柱净化,结合柱后光化学衍生化的高效液相色谱-荧光检测器建立同步检测常用中药材及染菌中药制剂中间体中的黄曲霉毒素B1,B2,G1,G2的方法.方法:采用免疫亲和柱净化洗脱结合柱后光化学衍生手段,建立黄曲霉毒素B1,B2,G1,G2的分析方法,并分别对14种中药材及染菌中药制剂中间体进行检测.结果:黄曲霉毒素B2和G2,B1和G1分别在0.15 ~ 6.0和0.5 ~20.0 ng·mL-1线性关系良好,方法准确稳定.所选的14种中药中川芎和柏子仁检测出黄曲霉毒素B1,而以染菌中药川芎所制备的5种提取物中均未检出黄曲霉毒素.结论:采用此方法检测常用中药材及其制剂中间体中的黄曲霉毒素无干扰性杂峰,结果准确可靠.

  9. Overuse of symptomatic medications among chronic (transformed migraine patients: profile of drug consumption Uso excessivo de medicações sintomáticas em pacientes com migrânea crônica (transformada: perfil de consumo medicamentoso

    Directory of Open Access Journals (Sweden)

    Abouch Valenty Krymchantowski

    2003-03-01

    Full Text Available Chronic daily headache and chronic (transformed migraine (TM patients represent more than one third of the subjects seen in specialized headache centers. Most of these patients may overuse symptomatic medications (SM taken on a daily basis to relieve headache and associated symptoms. The conversion to the daily or near-daily pattern of headache presentation is thought to be related to the medication overuse. The aim of this study was to evaluate the profile of SM consumption among transformed migraine patients attending a tertiary center. One hundred thirty three consecutive patients (22 men and 111 women, ages 17 to 80 with TM and overuse of SM according to the proposed criteria of Silberstein et al (1994, 1996 were prospectively studied. None of the patients were under treatment for other conditions. Among them, 73 (54.9% were using one category of SM, while 55 (41.3% and 5 (3.8% patients were taking simultaneously two and three categories of SM respectively. The categories of overused symptomatic medications varied from simple analgesics to narcotics, triptans and combinations of ergot derivatives and caffeine and of analgesics and caffeine. The average intake per patient per day was of 3 to 4 tablets and mostly of the patients overused simple analgesics (isolated or in combination with other substances (75.2%, caffeine containing drugs (71.4%, drugs containing ergotamine derivatives (26.1%, triptans (alone or combined (15.5%, drugs with narcotics or ansiolitics (13% and anti-inflammatory drugs (3.7%. The mechanisms by which the overuse of symptomatic medications may play a role in this transformation are uncertain but despite of the necessity of controlled trials to demonstrate the real role of such compounds in the development of transformed migraine, this study emphasizes the necessity for more rigorous prescribing guidelines for patients with frequent headaches.Os pacientes com cefaléia crônica diária e migrânea crônica (transformada

  10. Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage.

    Science.gov (United States)

    Sun, Kai; Fan, Jingyu; Han, Jingyan

    2015-01-01

    Ischemic stroke and ischemia/reperfusion (I/R) injury induced by thrombolytic therapy are conditions with high mortality and serious long-term physical and cognitive disabilities. They have a major impact on global public health. These disorders are associated with multiple insults to the cerebral microcirculation, including reactive oxygen species (ROS) overproduction, leukocyte adhesion and infiltration, brain blood barrier (BBB) disruption, and capillary hypoperfusion, ultimately resulting in tissue edema, hemorrhage, brain injury and delayed neuron damage. Traditional Chinese medicine (TCM) has been used in China, Korea, Japan and other Asian countries for treatment of a wide range of diseases. In China, the usage of compound TCM preparation to treat cerebrovascular diseases dates back to the Han Dynasty. Even thousands of years earlier, the medical formulary recorded many classical prescriptions for treating cerebral I/R-related diseases. This review summarizes current information and underlying mechanisms regarding the ameliorating effects of compound TCM preparation, Chinese materia medica, and active components on I/R-induced cerebral microcirculatory disturbances, brain injury and neuron damage. PMID:26579420

  11. Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage

    Directory of Open Access Journals (Sweden)

    Kai Sun

    2015-01-01

    Full Text Available Ischemic stroke and ischemia/reperfusion (I/R injury induced by thrombolytic therapy are conditions with high mortality and serious long-term physical and cognitive disabilities. They have a major impact on global public health. These disorders are associated with multiple insults to the cerebral microcirculation, including reactive oxygen species (ROS overproduction, leukocyte adhesion and infiltration, brain blood barrier (BBB disruption, and capillary hypoperfusion, ultimately resulting in tissue edema, hemorrhage, brain injury and delayed neuron damage. Traditional Chinese medicine (TCM has been used in China, Korea, Japan and other Asian countries for treatment of a wide range of diseases. In China, the usage of compound TCM preparation to treat cerebrovascular diseases dates back to the Han Dynasty. Even thousands of years earlier, the medical formulary recorded many classical prescriptions for treating cerebral I/R-related diseases. This review summarizes current information and underlying mechanisms regarding the ameliorating effects of compound TCM preparation, Chinese materia medica, and active components on I/R-induced cerebral microcirculatory disturbances, brain injury and neuron damage.

  12. Trends of Traditinal Chinese Materia Medica patents entried into China%进入中国的中草药专利态势

    Institute of Scientific and Technical Information of China (English)

    许钧钧

    2012-01-01

    Traditinal Chinese Materia Medica patents in China coming from foreign applicants are analyzed statistically, including annual filing distribution, assignee or applicant, field of technology, range of application, and so on. Analysis shows that the patent strategy of Japan in China is similar to that of the USA, and Republic of Korea patent strategy is similar to that of China. The development, application and patent protection of Chinese medicinal herbs in foreign countries have a good reference for China.%本文对中草药领域专利申请中进入中国的国外专利文献进行了统计分析,并详细分析了在中国申请量靠前的美国、日本、韩国的专利文献,包括历年申请分布、主要的申请者、技术领域与应用范围等.分析结果表明,日本与美国在中国具有相类似的专利布局,韩国则与中国国内的申请特点相似,美国、日本和韩国的中草药开发应用,以及中草药药材的专利保护等对中国中草药的研究和开发具有借鉴意义.

  13. Secretory Cavity Development and Its Relationship with the Accumulation of Essential Oil in Fruits of Citrus medica L. var. sarcodactylis (Noot.) Swingle

    Institute of Scientific and Technical Information of China (English)

    She-Jian Liang; Hong Wu; Xuan Lun; Dong-Wen Lu

    2006-01-01

    The developmental types of secretory cavities in Citrus remain controversial. The relationship between secretory cavity development and the accumulation of essential oil in fruits of Citrus species is also unknown. In order to develop better insights into these problems, histological, histochemical, and cytochemical methods were used to investigate secretory cavity development and the accumulation of essential oil at different developmental stages of fruits of Citrus medica L. var. sarcodactylis (Noot.) Swingle.The results indicate that the secretory cavity of the variety seemed to originate from an epidermal cell and a subepidermal cell. These two cells underwent successive divisions, resulting in the formation of two parts: (i) a conical cap; and (ii) a globular gland. The formation of the lumen was schizolysigenous. Regular changes in the size of vacuoles and the accumulation of essential oil were revealed during the process of secretory cavity development. In addition, when fruits were a light yellow or golden color, the structure of secretory cavities was well developed and the content of essential oil in a single fruit reached a maximum. It would be most appropriate to collect the fruit as a medicinal material at this time.

  14. [Textual research on Guang dong xin yu (New Sayings of Guangdong) quoted in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica].

    Science.gov (United States)

    Zhang, Ruixian; Zhang, Wei; Li, Jian; Liang, Fei

    2014-05-01

    Altogether 15 terms for Guang dong xin yu (New Sayings of Guangdong) were used in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica), including Yue yu (Cantonese sayings), Chong yu (Sayings from Insect Drug), Jie yu (Sayings from Crustacean Drug), Xin yu (New Sayings), Yue hai xiang yu (Fragrant Sayings from Cantonese Region), Yue zhi mu yu (Sayings from Plants in Cantonese Annals), Guang dong suo yu (Trivial Sayings from Guangdong), Yue shan lu (Records of Cantonese Mountains), Yue lu (Cantonese Records), Jiao guang lu (Joint Guangdong Records), Yue cao zhi (Records of Cantonese Grasses), Guang guo lu (Records of Guangdong Fruits), Nan yue suo ji (Trivial Records of Southern Canton), Guang zhi (Guangdong Records), Yue zhi (Cantonese Records) etc. dealing with 57 sorts of drugs (with individual overlapping ones), the author of Xin yu was Qu Dajun, a surviving fogy of the Ming Dynasty actively involved in the activities to restore the old dynasty and resist the Qing Dynasty, and was persecuted in the literary inquisition in which his works were burnt so that Zhao Xuemin, when quoting his texts, had to go in a roundabout way. PMID:25208840

  15. The background,present situation,problem and tactics of GAP of chinese materica medica%我国实施GAP的背景、现状、问题及对策

    Institute of Scientific and Technical Information of China (English)

    秦路平; 黄宝康; 郑汉臣

    2001-01-01

    In this paper,the background,present situation,problem and tactics of GAP(Good Agricultural Practice)of chinese materia medica are discussed.The main problems of the yielding of chinese materia medica are as followings:(1)Lack of close controlling standards and scientific detecting methods.(2)Decentralized management.low benefit and low controllability.(3)The pesticide residue and heavy metal content exceeding the provided standard.(4)Production and marketing disjointed,supervising and controlling intensity in the whole yielding process not enough.Thus,3 measures are put forward:(1)Strengthening the management of the quality of chinese materia medica,formulating strict and unitary quality controlling standards,setting up scientific checking methods.(2)Developing genuine drugs,establishing famous brands.(3)Establishing green chinese meateria medica yielding bases,to make the Chinese Materia Medica utilization sustainable.%本文论述了我国实施中药材GAP的背景、现状、问题及对策。目前我国中药材生产中存在的问题主要是:(1)缺乏严密的质量控制标准和科学检测手段;(2)生产经营分散,效益低,可控性差;(3)中药材农药残留量和重金属含量超标;(4)产供销脱节,产前、产中和产后全程监控力度不够。作者提出了应采取的几点措施:(1)加强中药材质量管理,制定严格统一的质量控制标准,建立科学的检测方法;(2)开发道地药材,创名牌产品;(3)建立绿色中药材生产基地,使中药材资源可持续利用。

  16. Progress in microbiome and its application to pharmacological and toxicological research of traditional Chinese materia medica%肠道微生物组及其在中药药理毒理研究中的应用

    Institute of Scientific and Technical Information of China (English)

    邓红; 吴纯启; 江涛; 王全军

    2016-01-01

    微生物组是一新兴研究领域,其研究涉及人类健康、农业、生物能源和环境等领域。其中,肠道微生物组是近年研究的热点。已有研究表明,肠道菌群与消化道疾病(炎症性肠病)、代谢性疾病(2型糖尿病)、心脑血管疾病(帕金森征)等有关。中药常作为补益药而长期大量服用,其口服进入胃肠道后,肠道菌群可影响中药药理和毒理作用。本文主要综述了微生物组的基本概况、常用的检测技术及其与何首乌所致肝毒性、黄芩直接作用于肠道、泽泻所致肾毒性及小柴胡汤所致肺炎等为代表的几种毒性作用间的关系。%Microbiome is a novel research field related to human health,agriculture,bio-energy and the environment. Gut microbiome has received much attention from researchers recently. Studies have shown that gut flora is related to some diseases,such as digestive disease(inflammatory bowel disease),metabolic disease(type 2 diabetes), cardie-cerebral vascular disease(Parkinson disease). Traditional Chinese materia medica(TCMM) has long been used as a tonic and taken in a large amount. Gut flora has an effect on pharmacology and toxicology of TCMM after entering the gastroin⁃testinal tract. This article is intended to review recent researches on microbiome,common detection techniques and the relationship with hepatotoxicity induced by Polygonum multiflorum Thunb.,scutel⁃laria baicalensis that directly affects the intestinal tract,nephrotoxicity induced by Rhizoma Alismatis and pneumonia induced by Xiao-Chaihu-Tang.

  17. A acetamida de pirrolidona como medicação auxiliar no tratamento da paralisia cerebral Pyrrolidone acetamide as an auxiliary drug in the treatment of cerebral palsy

    Directory of Open Access Journals (Sweden)

    Francisca Salete Pinheiro Chagas Ribeiro

    1976-06-01

    Full Text Available Vinte crianças, com diagnóstico de paralisia cerebral (PC e sob tratamento clássico, fisioterápico e pedagógico, receberam piracetam (acetamida de pirrolidona como medicação auxiliar. O objetivo foi melhorar os problemas de espasticidade, apredizagem, neurolabilidade, visando a um rendimento melhor do tratamento global da PC. O grupo medicado foi comparado com um grupo controle de 20 crianças que só eram objeto do tratamento habitual. A comparação mostrou resultados favoráveis no grupo medicado. A droga foi administrada na dose de 80 mg/kg/dia durante 10 semanas. Os critérios de avaliação dos resultados foram psicológicos, clínico, fisioterápico e pedagógico. A droga foi administrada em nova forma de apresentação: solução, para uso oral, a 6%.Twenty children, with the diagnosis of cerebral palsy (CP and under classical, physiotherapeutical and pedagogical, treatment, received piracetam (pyrrolidine acetamide as an auxiliary drug. The goal was to better spasticity, learning and nervous instability problems aiming at better results of over-all treatment of CP. The group that received the drug has been compared to a control group of 20 children treated by the customary treatment only. The comparison showed favourable results for the medicated group. The drug was administered in the dose of 80 mg/kg/day during 10 weeks. The criteria for evaluation have been psychological, clinical, physiotherapeutical and pedagogical. The drug has been given in a new form of presentation: 6% solution for oral use.

  18. Assessment of the potential of Allium sativum oil as a new medicament for non-vital pulpotomy of primary teeth

    OpenAIRE

    Mohammad, Shukry Gamal; Baroudi, Kusai

    2015-01-01

    Objective: The objective of this study was to compare the clinical and radiographic effects of Allium sativum oil and formocresol in nonvital pulpotomy in primary teeth. Materials and Methods: Twenty children ranging in age from 4 to 8 years were included in the study. In every one of those children, pulpotomy was indicated for the primary molars. Pulpotomy procedure was performed and the radicular pulp tissue of one molar was capped with A. sativum oil in a cotton pellet while the other mola...

  19. Clinical and Radiographic Evaluation of Allium sativum Oil as a New Medicament for Vital Pulp Treatment of Primary Teeth

    OpenAIRE

    Mohammad, Shukry Gamal; Raheel, Syed Ahmed; Baroudi, Kusai

    2014-01-01

    Background: The objective of this study was to compare between the clinical and radiographic effects of Allium sativum oil and those of formocresol in vital pulpotomy in primary teeth. Materials and Methods: A total of 20 children age ranged from 4 to 8 years were included in the study. In every one of those children, the primary molars indicated for pulpotomy. Pulpotomy procedure was performed, and the radicular pulp tissue of one molar capped with A. sativum oil in a cotton pellet, whereas ...

  20. Levomepromazina e atropina como medicações pré-anestésicas na anestesia pela associação tiletamina/zolazepam, em cães Comparison between levomepromazine and atropine as premedication agents before anesthesia using tiletamine/zolazepam in dogs

    Directory of Open Access Journals (Sweden)

    Luiz Gonzaga Pompermayer

    1998-03-01

    Full Text Available O objetivo desta pesquisa foi avaliar o emprego da atropina e da levomepromazina como medicações pré-anestésicas para a anestesia pela associação tiletamina/zolazepam. Foram empregados 30 cães, distribuídos em três grupos iguais. O grupo 1 (controle foi tratado com 0,2 ml/kg de solução fisiológica (placebo por via intravenosa; o grupo 2 com 0,044mg/kg de sulfato de atropina por via subcutânea e o grupo 3 com 1mg/kg de cloridrato de levomepromazina por via intravenosa. Quinze minutos após, todos os grupos receberam a associação tiletamina/zolazepam na dose de 10mg/kg por via intramuscular. Antes da medicação pré-anestésica, 15 minutos após a mesma e aos 15, 30, 60 e 105 minutos após a administração da associação tiletamina/zolazepam foram registrados: ECG, temperatura, freqüência respiratória, volume corrente, volume minuto, freqüência cardíaca, pressão arterial, valores hemogasométricos arteriais, graus de analgesia e miorrelaxamento e reflexos protetores. Outros dados como: secreção salivar, período de latência, período anestésico hábil e período de recuperação foram igualmente mensurados para efeito comparativo. De acordo com os resultados obtidos concluiu-se que o sulfato de atropina não deve ser administrado como medicação pré-anestésica, por potencializar a taquicardia induzida pela associação tiletamina/zolazepam. A levomepromazina, além de inibir a sialorréia, mantém a estabilidade cardiorrespiratória e apresenta ação potencializadora dos efeitos anestésicos da associação.The aim of this study was to investigate the effect of levomepromazine and atropine sulfate as a premedication to the dissociative anesthesia produced by a tiletamine/zolazepam combination. Ten dogs were randomly assigned to each of the three groups: control, atropine and levomepromazine. Fifteen minutes before tiletamine/zolazepam, the dogs were treated either with atropine sulfate (0.044mg/kg, subcutaneously

  1. Ions Release and pH of Calcium Hydroxide-, Chlorhexidine- and Bioactive Glass-Based Endodontic Medicaments.

    Science.gov (United States)

    Carvalho, Ceci Nunes; Freire, Laila Gonzales; Carvalho, Alexandre Pinheiro Lima de; Duarte, Marco Antonio Húngaro; Bauer, José; Gavini, Giulio

    2016-01-01

    This study evaluated pH and release of calcium, sodium and phosphate ions from different medications in human dentin. Fifty premolars were prepared and randomly divided into groups: (CHX) - 2% chlorhexidine gel; (CHX + CH) - CHX + calcium hydroxide PA; (CH) - CH + propylene glycol 600; (NPBG) - experimental niobium phosphate bioactive glass + distilled water; (BG) - bioactive glass (Bio-Gran) + distilled water. The specimens were immersed in deionized water and the pH variations were measured. The quantification of ions in the solutions was made by inductively coupled plasma - atomic emission spectroscopy (ICP/AES) at 10 min, 24 h, 7, 14, 21 and 30 days. The results were analyzed by ANOVA and Tukey`s test, with a significance level of 5%. CH had the highest level of calcium ions release at 30 days, while CHX and BG released more sodium ions. BG, NPBG and CHX released a higher amount of phosphate ions. The pH of CH was significantly higher compared with the other groups. CH favored the greatest increase of pH and calcium ions release. The bioactive glasses released more sodium and phosphate ions and presented an alkaline pH immediately and after 30 days. PMID:27224568

  2. MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats.

    Science.gov (United States)

    Atkinson, Laura L; Kelly, Sandra E; Russell, James C; Bar-Tana, Jacob; Lopaschuk, Gary D

    2002-05-01

    Intracellular triacylglycerol (TG) content of liver and skeletal muscle contributes to insulin resistance, and a significant correlation exists between TG content and the development of insulin resistance. Because acetyl-CoA carboxylase (ACC) is the rate-limiting enzyme for liver fatty acid biosynthesis and a key regulator of muscle fatty acid oxidation, we examined whether ACC plays a role in the accumulation of intracellular TG. We also determined the potential role of 5'-AMP-activated protein kinase (AMPK) in this process, since it can phosphorylate and inhibit ACC activity in both liver and muscle. TG content, ACC, and AMPK were examined in the liver and skeletal muscle of insulin-resistant JCR:LA-cp rats during the time frame when insulin resistance develops. At 12 weeks of age, there was a threefold elevation in liver TG content and a sevenfold elevation in skeletal muscle TG content. Hepatic ACC activity was significantly elevated in 12-week-old JCR:LA-cp rats compared with lean age-matched controls (8.75 +/- 0.53 vs. 3.30 +/- 0.18 nmol. min(-1). mg(-1), respectively), even though AMPK activity was also increased. The observed increase in hepatic ACC activity was accompanied by a 300% increase in ACC protein expression. There were no significant differences in ACC activity, ACC protein expression, or AMPK activity in the skeletal muscle of the 12-week JCR:LA-cp rats. Treatment of 12-week JCR:LA-cp rats with MEDICA 16 (an ATP-citrate lyase inhibitor) resulted in a decrease in hepatic ACC and AMPK activities, but had no effect on skeletal muscle ACC and AMPK. Our data suggest that alterations in ACC or AMPK activity in muscle do not contribute to the development of insulin resistance. However, increased liver ACC activity in the JCR:LA-cp rat appears to contribute to the development of lipid abnormalities, although this increase does not appear to occur secondary to a decrease in AMPK activity.

  3. A terapia medicamentosa no idoso: cuidados na medicação Pharmacotherapy in the elderly: precautions with medication

    Directory of Open Access Journals (Sweden)

    Otávio de Tolêdo Nóbrega

    2005-04-01

    Full Text Available A literatura médica reconhece que o envelhecimento predispõe a um consumo aumentado de medicamentos prescritos e não-prescritos. No entanto, mudanças fisiológicas relacionadas ao envelhecimento, tais como a modificação da composição corporal e a redução das funções renal e hepática, podem alterar em muito a farmacocinética e a farmacodinâmica de diversos fármacos, fazendo com que indivíduos idosos estejam suscetíveis com maior freqüência a efeitos adversos ou terapêuticos mais intensos. Neste cenário, a literatura médica tem sido constantemente enriquecida com estudos que apontam explicitamente para medicamentos específicos ou categorias de medicamentos cujo consumo por indivíduos idosos deve ser evitado ou utilizado com cautela. Este trabalho se propõe a descrever brevemente algumas informações consensuais acerca destes medicamentos impróprios para idosos, ressaltando alguns fármacos que se encontram disponíveis à população brasileira.Medical literature points out that ageing predisposes to a greater consumption of prescription and "over the counter" medicines. However, physiological changes related to aging such as modification of body composition and reduction of the renal and hepatic functions may significantly alter the pharmacokinetics and pharmacodynamics of several drugs, rendering elderly people susceptible to much more intense adverse or therapeutic effects. In this scenario, the medical literature has been continuously enriched with studies pointing out explicit medications or medications categories that should be generally avoided or used with caution by older adults. This work has the purpose of briefly describing a few, consensual information on these inappropriate drugs for the elderly, addressing some active principles available for the Brazilian population.

  4. Decision theory on the quality evaluation of medical images; A teoria da decisao na avaliacao da qualidade da imagem medica

    Energy Technology Data Exchange (ETDEWEB)

    Lessa, Patricia Silva

    2001-10-01

    The problem of quality has been a constant issue in every organization.One is always seeking to produce more, to do it at a lower cost, and to do it with better quality. However, in this country, there is no radiographic film quality control system for radiographic services. The tittle that actually gets done is essentially ad hoc and superficial. The implications of this gap, along with some other shortcomings that exist in process as a whole (the state of the x-ray equipment, the adequate to use in order to obtain a radiography, the quality of the film, the processing of the film, the brightness and homogeneity of the viewing boxes, the ability of the radiologist), have a very negative impact on the quality of the medical image, and, as result, to the quality of the medical diagnosis and therapy. It frequently happens that many radiographs have to be repeated, which leads to an increase of the patient's exposure to radiation, as well as of the cost of the procedure for the patient. Low quality radiographs that are not repeated greatly increase the probability of a wrong diagnosis, and consequently, of inadequate therapeutical procedures, thus producing increased incidence of bad outcomes and higher costs. The paradigm proposed in order to establish a system for the measurement of the image's quality is Decision Theory. The problem of the assessment of the image is studied by proposing a Decision Theory approach. The review of the literature reveals a great concern with the quality of the image, along with an absence of an adequate paradigm and several essentially empirical procedures. Image parameters are developed in order to formalize the problem in terms of Decision Theory, and various aspects of image digitalisation are exposed. Finally, a solution is presented, including a protocol for quality control. (author)

  5. Análise de causa raiz: avaliação de erros de medicação em um hospital universitário Análisis de causa raíz: evaluación de errores de medicación en un hospital universitario Root cause analysis: evaluation of medication errors at a university hospital

    OpenAIRE

    Thalyta Cardoso Alux Teixeira; Silvia Helena De Bortoli Cassiani

    2010-01-01

    Os objetivos deste estudo foram identificar e analisar os tipos de erros de medicação observados nas doses de medicamentos que foram preparadas e administradas de forma diferente daquelas prescritas. Estudo descritivo, utilizando o método de análise de causa raiz, que realizou uma análise secundária de dados de um estudo já existente. No estudo, 74 erros de medicação foram identificados, durante o preparo e a administração de medicamentos pela equipe de enfermagem. Erros de dose (24,3%), erro...

  6. Exploration of 3D Printer Models in Teaching Identification of Chinese Meteria Medica%《中药鉴定学》性状教学引入3D 纸模型构建技术初探

    Institute of Scientific and Technical Information of China (English)

    车苏容; 苏碧丽; 魏政熙; 文琛; 曾松

    2013-01-01

    The characteristics of Chinese meteria medica is an important part in teaching the course of Identification of Chinese Meteria Medica.It needs the real materials to display during teaching which would easily be damaged or rotten , and some of them are very ex-pensive.The development of 3D technology which owns the advantages of high quality with reasonable price and visual display can be a potential teaching method to change the traditional teaching way .%《中药鉴定学》性状教学的是直观形态教学为主的学科,教学用药材样本易变质受损,部分药材价格昂贵。3D纸模型技术的发展,物美价廉、表现力强,具有诸多优势,成为一个潜力具大的教学手段,引入本学科的教学将对传统教学模式带来改变。

  7. Medication errors and drug-dispensing systems in a hospital pharmacy Erros de medicação e sistemas de dispensação de medicamentos em farmácia hospitalar

    Directory of Open Access Journals (Sweden)

    Tânia Azevedo Anacleto

    2005-08-01

    Full Text Available Pharmacies permeate and interconnect various actions developed in different sectors within the complex process of the use of drugs in a hospital. Dispensing failures mean that a breach has occurred in one of the last safety links in the use of drugs. Although most failures do not harm patients, their existence suggests fragility in the process and indicates an increased risk of severe accidents. Present concepts on drug-related incidents may be classified as side effects, adverse effects, and medication errors. Among these are dispensing errors, usually associated with poor safety and inefficient dispensing systems. Factors associated with dispensing errors may be communication failures, problems related to package labels, work overload, the physical structure of the working environment, distraction and interruption, the use of incorrect and outdated information sources and the lack of patient knowledge and education about the drugs they use. So called banal dispensing errors reach significant epidemiological levels. The purpose of this paper, which is part of a study on the occurrence of dispensing errors in the pharmacy of a large hospital, is to review the main concepts that guide studies on adverse effects and to provide an update on dispensing errors.A farmácia hospitalar permeia e interliga várias ações desenvolvidas em diferentes setores no complexo processo de utilização do medicamento dentro do hospital. Falhas na dispensação significam o rompimento de um dos últimos elos na segurança do uso dos medicamentos. Ainda que grande parte dessas falhas não cause danos aos pacientes, sua existência denuncia fragilidade no processo e indica, em uma relação direta, riscos maiores de ocorrência de acidentes graves. Os conceitos atuais dos incidentes relacionados a medicamentos podem ser categorizados em grupos e incluem as reações adversas, os eventos adversos e os erros de medicação. Dentre estes se inclui os erros de dispensa

  8. Chinese Marine Materia Medica. By Huashi Guan and Shuguang Wang. Shanghai Scientific and Technical Publishers, China Ocean Press, and Chemical Industry Press: Shanghai, Beijing, China, 2009; Hardback, 7064 pp; ¥ 2920; ISBN 978-7-5323-9958-1/R•2707; ISBN 978-7-5323-9973-4/R•2708; ISBN 978-7-1220-6012-9

    Directory of Open Access Journals (Sweden)

    Peter Proksch

    2014-01-01

    Full Text Available China is one of the first countries to use marine materia medica for treating diseases. Ancient books on Chinese herbology, such as Shennong Bencaojing (Shennong’s Classic of Materia Medica, Xinxiu Bencao (Newly Revised Materia Medica and Bencao Gangmu (Compendium of Materia Medica, have detailed more than 110 marine herbs and thousands of marine herbal formulas (including those for Chinese food therapy. A great deal of information on marine herbs and their applications in medicine, collected over thousands of years, has provided an important foundation for modern research in the area of marine drugs. Thanks to these records and references, the research and development of modern Chinese marine drugs continue to evolve and mature. Since the middle of the 20th century, special attention has been paid to traditional Chinese medicine, resulting in a significant increase in the number of newly discovered marine herbs. Comprehensive surveys in the past have also created a wealth of data on the pharmacology, chemistry, biology and ecology of marine medicinal bioresources. After thousands of years of research, historical references to traditional marine herbs are scattered throughout ancient books, local chronicles, medical books, or monographs on medicinal herbs. Unfortunately, there is no systematic way to collate or scientifically verify these references. Furthermore, during the last century, scientists around the world have accumulated large quantities of information on marine natural products, but these are also scattered throughout academic books and journals.

  9. Hartlaub & Trinks Pure Materia Medica: to save it or to lose it? La Materia Médica Pura de Hartlaub & Trinks: salvarla o perderla? A Matéria Médica Pura de Hartlaub & Trinks: salvá-la ou perdé-la?

    Directory of Open Access Journals (Sweden)

    Elias Carlos Zoby

    2003-01-01

    Full Text Available The Hartlaub’s & Trinks’ Materia Medica Pura (Reine Arzneimittellehre stands among few large collections of provings owned by the homeopaths. It has never been wholly translated to English, and perhaps to any other language. As a result, few people know and fewest have used it. However this materia medica was instrumental to make Hahnemann’s and Allen’s largest books. Any pathogenetic symptom is always a fact to which time only will add clearness and facility to understanding. Since it wasn’t translated, the homoeopathic repertories, written originally in English, don’t include a large part of its symptoms. Books that aren’t read and published tend to disappear and, in the case we are mentioning, a loss would be large to Homeopathy. The author compares the symptoms of materia medica and repertory. This research is made on original texts and afterwards compared to the translations. So he found, among the symptoms in Hartlaub & Trinks,many symptoms that aren’t in any other next, and connects it to some exemplary cases. Aspects that have been presented confirmed the importance of Hartlaub’s & Trinks’ Materia Medica Pura once it contains symptoms that are not presented in any other text, and correct those that were wrongly translated. The rescue stops being just a bibliophiler preciosity to show itself as a venture when one can find in its symptoms similarities with the patients. So Homeopathy presents itself in all its beauty and capacity of healing.

  10. The clinical efficacy observation of treating pediatric acute tonsillitis with Chinese materia medica taken as tea%中药代茶饮治疗儿童急性扁桃体炎30例疗效观察

    Institute of Scientific and Technical Information of China (English)

    刘娥; 吴平; 李克明

    2014-01-01

    目的:观察中药代茶饮治疗儿童急性扁桃体炎的疗效。方法:60例儿童急性扁桃体炎随机分为治疗组30例和对照组30例,治疗组采用口服抗生素+中药代茶饮,对照组采用静滴抗生素治疗,观察两组临床疗效及治疗后症状、体征消失时间。结果:治疗组疗效显著,各症状、体征消失时间均短于对照组,差异有统计学意义(P<0.05)。两组治疗期间均未出现相关不良反应。结论:中药代茶饮治疗儿童急性扁桃体炎疗效显著。%Objective:To observe the clinical efficacy on treating pediatric acute tonsillitis with Chinese materia medica.Method:60 Children with pediatric acute tonsillitis were randomized into treatment group and control group.Children in the treatment group were treated with oral antibiotics and Chinese Materia Medica(taken as tea). Other children in the control group were treated with Intravenous antibiotics.Observe the clinical efficacy of the two groups, as well as the disappearing time of the symptoms and signs.Result:The clinical efficacy of the treatment group is significant.The disappearing time of various symptoms and signs of the treatment group is shorter than that of the control group.The difference is statistically significant(P<0.05).Children in both groups had no adverse reactions during the treatment.Conclusion:Taking Chinese materia medica as tea has a significant effect on treating pediatric acute tonsillitis.

  11. 自乳化释药系统在难溶性中药制剂中的应用%Self-emulsifying delivery systems and its application on preparations of poorly soluble Chinese materia medica

    Institute of Scientific and Technical Information of China (English)

    叶珍珍; 张建; 崔升淼

    2012-01-01

    自乳化释药系统可以提高难溶性药物的溶出度和生物利用度,在中药方面的应用具有良好的发展前景.文章综述自乳化释药系统的定义、特点、体内外质量评价指标、在难溶性中药制剂中的应用以及存在问题与对策.%The dissolution and the bioavailability of water-insoluble drugs can be improved by the utilization of serf-emulsifying delivery systems (SEDDS), so SEDDS has a promising application in the field of Chinese medicine. The definition, characterization, indexes in vivo and in vitro evaluations, application to preparations of poorly soluble Chinese materia medica, problems and countermeasures are reviewed.

  12. 设计性实验在中药化学实验教学中的应用%Application of design experiment in experimental of chemistry of Chinese materia medica

    Institute of Scientific and Technical Information of China (English)

    陈红; 陈卫琳

    2012-01-01

      设计性实验在中药化学实验教学中的应用过程:教师给定范围—学生查阅文献命题—设计实验方案—教师辅助指导—学生独立操作—分析结果—得出结论。整个过程以学生为主,教师为辅%  Application of design experiment in experimental of chemistry of Chinese materia medica. The students are in a given range, they read some literature-assign a topic, design the experimental program, the teacher counselling guidance, the students independent operation, analyze the results, arrive at a conclusion. The whole process to students is given priority to, supplemented by the teacher.

  13. Current research status of identification method for Chinese materia medica based on bionic olfaction%基于仿生嗅觉的中药材鉴别方法研究现状*

    Institute of Scientific and Technical Information of China (English)

    周华英; 李钟; 刘红秀

    2016-01-01

    概述了中药材“气味”鉴别的重要地位;综述了仿生嗅觉技术机理及其在中药材鉴别领域的研究现状,同时展望了仿生嗅觉技术在中药材领域的应用前景。%The importance of "odor" identification is introduced in this paper. Then the mechanism of the bionic olfactory technology,as well as the current research status about the identification of Chinese herbal medicines based on the technology is summarized;Lastly,some conclusions and application prospect about the bionic olfactory technology in the field of Chinese materia medica will be discussed.

  14. To comparatively evaluate the antimicrobial efficacy of chlorhexidine, nisin and linezolid as an intracanal medicament on Enterococcus faecalis: An in vitro study

    Directory of Open Access Journals (Sweden)

    Geethu Somanath

    2015-01-01

    Results: In group Nisin, the mean CFU was 10.6250 at 24 hrs, 6.6250 at 72 hrs and 6.2500 after 1 week respectively (statistically significant. In group Chlorhexidine, mean CFU was found to be the lowest of 10.5000 at 24 hrs, with further gradual increase to 13.7500 at 72 hrs and further increase to 15.8750 by 1 week. Similarly, in group linezolid , the mean CFU was found to decrease from 49.0000 at 24 hrs to 29.8750 at 72hrs and then increase to 34.8750 in 1 week

  15. Characterisation of the efficacy of endodontic medications using a three-dimensional fluorescent tooth model: An ex vivo study.

    Science.gov (United States)

    Chen, Emily W; Carey, Alison J; Ulett, Glen C; George, Roy

    2015-08-01

    The purpose of this study was to establish a three-dimensional fluorescent tooth model to investigate bacterial viability against intra-canal medicaments across the thickness and surface of root dentine. Dental microbial biofilms (Enterococcus faecalis and Streptococcus mutans) were established on the external root surface and bacterial kill was monitored over time against intra-canal medicament (Ca(OH)2 ) using fluorescent microscopy in conjunction with BacLight SYTO9 and propidium iodide stains. An Olympus digital camera fitted to SZX16 fluorescent microscope captured images of bacterial cells in biofilms on the external root surface. Viability of biofilm was measured by calculating the total pixel area of green (viable bacteria) and red (non-viable bacteria) for each image using ImageJ® software. All data generated were assessed for normality and then analysed using a Mann-Whitney t-test. The viability of S. mutans biofilm following Ca(OH)2 treatment showed a significant decline compared with the untreated group (P = 0.0418). No significant difference was seen for E. faecalis biofilm between the Ca(OH)2 and untreated groups indicating Ca(OH)2 medicament is ineffective against E. faecalis biofilm. This novel three-dimensional fluorescent biofilm model provides a new clinically relevant tool for testing of medicaments against dental biofilms. PMID:25583457

  16. Students' conceptions of the medical profession; an interview study

    OpenAIRE

    Nieuwhof, M.G.H.; Rademakers, J.J.D.J.M.; Kuyvenhoven, M.M.; Soethout, M.B.M.; ten Cate, Th.J.

    2005-01-01

    Students' beliefs and attitudes towards the medical profession have been studied in relation to career choices, but most research has been restricted to either predetermined aspects or to a limited number of specialties. This study aimed at getting unprompted insight in the students' perceptions of their future profession in dimensions that may be determinants of study success and career choice. Undergraduate and graduated medical students were interviewed and asked to characterize the medica...

  17. 响应面法优化佛手总黄酮提取工艺%Response Surface Methodology for Optimization of Extraction Technology of Total Flavonoids from Citrus medica var.sarcodactylis

    Institute of Scientific and Technical Information of China (English)

    刘玉芬; 夏海涛

    2013-01-01

    Total flavonoids were extracted from bergamot(Citrus medica var.sarcodactylis) using alcohol as extractant.The extraction conditions including extraction temperature,extraction time and liquid to solid ratio were optimized by Box-Behnken response surface methodology on the base of single factor tests using the yield of total flavonoids as indicator.The results showed that the optimum extraction conditions of total flavonoids from bergamot were as follows,volume fraction of extractant alcohol solution,60%; extraction temperature,69 ℃; extraction time,1.9 h; liquid to solid ratio Valcobol∶mbergamot=32∶l(mL/g)and extracting twice.The yield of total flavonoids from bergamot was 0.565 9% under the optimal extraction conditions.%以乙醇溶液为提取溶剂从佛手(Citrus medica var.sarcodactylis)中提取总黄酮,在单因素试验的基础上以佛手总黄酮提取率为指标,选择提取温度、提取时间和液料比3个因素进行Box-Behnken中心组合试验,优化佛手总黄酮的提取工艺条件.结果表明,优化的提取工艺条件为体积分数60%的乙醇溶液作提取溶剂、提取温度69℃、提取时间1.9 h、液料比V乙醇∶m佛手粉=32∶1(mL/g)、提取2次,该条件下佛手总黄酮提取率为0.565 9%.

  18. Translation and Transliteration of Plant names in Ḥunayn b. Iḥsāq´s and Iṣṭifān b. Bāsil´s Arabic version of Dioscorides, De materia medica

    Directory of Open Access Journals (Sweden)

    Touwaide, Alain

    2009-12-01

    Full Text Available This paper deals with the Arabic translation of De materia medica by the Greek author Dioscorides (1st century A.D., particularly the rendering of plant names, which were sometimes properly translated and sometimes transliterated from the Greek. According to a traditional interpretation, the transliteration strategy was used by the translators when they did not know the exact Arabic equivalent of the plant names. I re-examine this interpretation here taking into account the role of plant names in the Greek text and the Andalusian works of botanical lexicography. As a result, I propose to interpret transliterations as a mean used by translators to keep visible the structure of the work, in which plant names played a certain role.

    Este artículo se ocupa de la traducción árabe del texto griego del tratado De materia medica de Dioscórides (siglo I, especialmente de los fitónimos que, en unos casos, fueron traducidos al árabe y, en otros, transliterados del griego. Según la interpretación tradicional, la transliteración era una estrategia utilizada por los traductores cuando no conocían el equivalente exacto árabe de los nombres de las plantas. Se propone en este trabajo una revisión de esta interpretación, teniendo en cuenta el importante papel que los nombres de las plantas desempeñan en el texto griego, así como en las obras de los lexicógrafos y botánicos andalusíes, llegando a la conclusión de que las transliteraciones eran una técnica utilizada por los traductores para mantener visible la estructura general de la obra de Dioscórides, basada en gran parte en la nomenclatura de las plantas.

  19. Screening of most efficient medicament for controlling bacterial fruit blotch of grafted watermelon seedlings using seed soaking method%药物浸种处理防治西瓜嫁接苗细菌性果斑病试验

    Institute of Scientific and Technical Information of China (English)

    何毅; 韦志扬; 李文信; 覃斯华; 黄金艳; 洪日新; 李天艳

    2011-01-01

    [目的]筛选防治西瓜嫁接苗细菌性果斑病(BFB)的种子处理有效药剂,为防治BFB提供科学依据.[方法]先以17种药剂的200倍液对西瓜种子进行浸种处理,依据嫁接苗BFB的发病率初步筛选防治BFB的有效药剂;以初选有效药剂进行不同浓度、不同混合组合及不同浸种方法处理对嫁接苗BFB的防治效果试验.[结果]初试结果表明,2%春雷霉素处理西瓜嫁接苗BFB病株率较低,可用于下一步试验.复试结果表明,2%春雷霉素100、200、300、400、500倍液浸种处理有籽西瓜种子,嫁接后12d嫁接苗BFB发病率分别为1.0%、36.7%、94.3%、95.7%、98.1%;2%春雷霉素200倍+乐尤病、72%农用链霉素、72%农用硫酸链霉素800倍液浸种处理有籽西瓜种子,嫁接后12 d嫁接苗BFB发病率为1.0%~2.4%;2%春雷霉素100、200、300、400倍液处理西瓜干种子,嫁接后12 d有籽西瓜嫁接苗BFB发病率为0.5%~5.7%,无籽西瓜嫁接苗BFB发病率为8.1%~11.4%;2%春雷霉素400倍+乐无病、72%农用链霉素、72%农用硫酸链霉素1000倍液处理西瓜干种子,嫁接后12 d有籽西瓜嫁接苗BFB发病率为1.0%~2.0%,无籽西瓜嫁接苗BFB发病率为6.7%~9.5%.[结论]2%春雷霉素可作为防治西瓜嫁接苗BFB的首选特效药,推荐浓度为2%春雷霉素400倍或以2%春雷霉素400倍搭配其他杀菌剂使用.%[Objective]The present experiment was conducted to screen effective medicaments for controlling bacterial fruit blotch (BFB) of grafted watermelon seedlings, and to provide scientific basis for BFB control. [Method]Seeds of watermelon were soaked in 200 times diluted solutions of 17 different kinds of medicaments, the effectiveness of different medicaments was screened preliminarily by observing rate of BFB incidence on grafted seedlings. Different concentrations and combinations were also used to screen the most effective medicament. [Result]The rate of BFB incidence on grafted watermelon seedlings, treated

  20. Análise de causa raiz: avaliação de erros de medicação em um hospital universitário Análisis de causa raíz: evaluación de errores de medicación en un hospital universitario Root cause analysis: evaluation of medication errors at a university hospital

    Directory of Open Access Journals (Sweden)

    Thalyta Cardoso Alux Teixeira

    2010-03-01

    Full Text Available Os objetivos deste estudo foram identificar e analisar os tipos de erros de medicação observados nas doses de medicamentos que foram preparadas e administradas de forma diferente daquelas prescritas. Estudo descritivo, utilizando o método de análise de causa raiz, que realizou uma análise secundária de dados de um estudo já existente. No estudo, 74 erros de medicação foram identificados, durante o preparo e a administração de medicamentos pela equipe de enfermagem. Erros de dose (24,3%, erros de horário (22,9% e medicamentos não autorizados (13,5% foram os mais frequentes. Assim, a análise de causa raiz foi realizada, identificando múltiplos fatores que contribuíram para a ocorrência dos erros, e estratégias e recomendações foram apresentadas para evitá-los.Los objetivos de este estudio consistieron en identificar y analizar los tipos de errores de medicación observados en las dosis de medicamentos que fueron preparadas y administradas de modo diferente respecto del cual fueron prescriptas. El estudio fue de carácter descriptivo, se utilizó el método de análisis de causa raíz, efectuado en forma secundaria sobre los resultados de un estudio ya existente. En el estudio, 74 errores de medicación fueron identificados durante la preparación y la administración de medicamentos por parte del equipo de Enfermería. Errores de dosis (24,3%, errores de horario (22,9% y medicamentos no autorizados (13,5% fueron los más frecuentes. Así, el análisis de causa raíz fue realizado, identificándose múltiples factores que contribuyeron para la ocurrencia de los errores. Fueron presentadas estrategias y recomendaciones para evitarlos.The objectives of this study were to identify and analyze the types of medication errors observed in doses prepared and administered differently from those prescribed. It is a descriptive study using the root cause analysis method, in which a secondary analysis of data from a previously existing

  1. Condutas adotadas por técnicos de enfermagem após ocorrência de erros de medicação Conductas adoptadas por técnicos de enfermería después de ocurrir errores de medicación Conducts adopted by nursing technicians after the occurrence of medication errors

    Directory of Open Access Journals (Sweden)

    Jânia Oliveira Santos

    2010-06-01

    Full Text Available OBJETIVO: Identificar e analisar as condutas adotadas por técnicos de enfermagem após a ocorrência de erros de medicação. MÉTODOS: Estudo descritivo, de abordagem qualitativa, realizado com 23 técnicos de enfermagem de um hospital de ensino de Goiânia-GO. Os dados foram coletados através de entrevistas semi-estruturadas gravadas e analisadas segundo os pressupostos de Bardin. RESULTADOS: Os resultados evidenciaram duas categorias: tomando condutas relacionadas à comunicação do erro (ao médico, à enfermeira, registrando no prontuário e não comunicando o erro e adotando condutas direcionadas ao paciente (observação do paciente, monitorização e minimização das consequências. CONCLUSÃO: Ressalta-se a necessidade de que as instituições de saúde adotem uma cultura de transparência em relação aos erros de medicação, com a criação de políticas e padronizações para notificação, divulgação e fortalecimento de medidas preventivas.OBJETIVO: Identificar y analizar las conductas adoptadas por técnicos de enfermería después de ocurrir errores de medicación. METODOS: Se trata de un estudio descriptivo con abordaje cualitativo, realizado en 23 técnicos de enfermería de un hospital de enseñanza, en la ciudad de Goiania, estado de Goiás. Los datos fueron recolectados a través de entrevistas semiestructuradas grabadas y analizadas según los conceptos de Bardin. RESULTADOS: Los resultados evidenciaron dos categorías: tomando conductas relacionadas a la comunicación del error (al médico, a la enfermera, registrando en la ficha y no comunicando el error y, adoptando conductas dirigidas al paciente (observación del paciente, monitorización y minimización de las consecuencias. CONCLUSIÓN: Se resalta la necesidad de que las instituciones de salud adopten una cultura de transparencia en relación a los errores de medicación, con la creación de políticas y la estandarización de las notificaciones, con la

  2. Trabajo y salud de las docentes de la Universidad Nacional de Córdoba: uso de medicamentos/sustancias lícitas y plan materno infantil Trabalho e saúde das docentes da Universidade Nacional de Córdoba: uso de medicamentos/substâncias lícitas e plano materno infantil Work and health of the Cordoba National University teachers: medicaments/legal drugs use and infantile-maternal plan

    Directory of Open Access Journals (Sweden)

    Marta Susana Giacone

    2004-04-01

    Full Text Available Este trabajo tuvo como objetivo investigar condiciones de existencia, proceso de trabajo y salud y consumo de medicamentos de docentes universitarias en edad reproductiva. Además, intentó conocer uso, opiniones y sugerencias de usuarias del Plan Materno Infantil de la Obra Social Universitaria. El estudio se encaminó desde la perspectiva teórico-metodológica del materialismo histórico y dialéctico, se delineó como investigación social desarrollada a través de un estudio de campo descriptivo-correlativo e estratégico en una muestra total de 50 personas. Los resultados indican presencia de condiciones de existencia y trabajo deterioradas, afectando el perfil de salud de las docentes y el consumo de medicamentos. Alto porcentaje de las entrevistadas consideró el Plan Materno Infantil muy bueno o bueno y enfatizó la necesidad de mejor información a cerca de ella.Este trabalho teve como objetivo investigar condições de existência, processo de trabalho e saúde e consumo de medicamentos de docentes universitárias em idade reprodutiva. Além disso, buscou conhecer uso, opiniões e sugestões de usuárias do Plano Materno Infantil da Obra Social Universitária. O estudo encaminhou-se pela perspectiva teórico-metodológica do materialismo histórico e dialético, delineou-se como investigação social desenvolvida por um estudo de campo descritivo-correlativo e estratégico, em uma mostra total de 50 pessoas. Os resultados indicam presença de condições de existência e trabalho deterioradas, afetando o perfil de saúde das docentes e o consumo de medicamentos. Alta porcentagem das entrevistadas considerou o Plano Materno Infantil bom ou muito bom e enfatizou a necessidade de melhor informação sobre ele.This study aimed to investigate university teachers in reproductive age' life conditions, work and health process and medicaments use. Beside, aimed research the use, opinions and suggestions of Infantile-Maternal Plan of the

  3. Eventos adversos com medicação em Serviços de Emergência: condutas profissionais e sentimentos vivenciados por enfermeiros Eventos adversos con medicaciones en Servicios de Urgencia: conductas profesionales y sentimientos vividos por los enfermeros Medication adverse events in Emergency Department: nurse's professional conduct and personal feelings

    Directory of Open Access Journals (Sweden)

    Audry Elizabeth dos Santos

    2005-08-01

    Full Text Available O estudo teve por objetivos verificar as condutas profissionais e os sentimentos dos enfermeiros de serviços de Emergência frente a um evento adverso com medicação e suas associações com a idade, tempo de formado, tempo de experiência na área e vivência anterior com esse tipo de evento. A amostra foi constituída por 116 enfermeiros atuantes em 15 hospitais gerais do município de São Paulo que responderam a um questionário sobre uma situação fictícia com erro de medicação. Os resultados revelaram as seguintes condutas em ordem de prioridade: comunicar ao médico (69,8%, intensificar os cuidados ao paciente (55,1% e anotar no prontuário (28,0%. A preocupação (79,3% foi a manifestação afetiva predominante (79,3%, seguida pela impotência e raiva (22,4%, cada um e insegurança (24,4%. A análise das variáveis mostrou relação entre as condutas profissionais e tempo de formado, enquanto que os sentimentos relacionaram-se com a idade e vivência anterior com esse tipo de evento.El estudio tuvo como objectivo verificar las conductas profesionales y los sentimientos de los enfermeros del servicio de emergencia que se encuentra adelante de un evento adverso com medicación y sus asociaciones com la idad, tiempo del graduado, tiempo de experiencia en la area y vivencia anterior com neste tipo del evento. La muestra fue constituida por 116 enfermeros actuantes em 15 hospitales generales del municipio de São Paulo que respondieram a un cuestionario sobre una situación ficticia com error de medicaciones. Los resultados demonstraron las siguientes conductas en orden de prioridades: comunicar al médico (69,8%, intensificar los cuidados al paciente (55,1% y anotar en el prontuario (28,0%. La preocupacion (79,3% fue la manifestacion afectiva predominante (79,3%, seguida por la impotencia y rabia (22,4% cada una y inseguridad (24,4%. La analise de las variables demonstró relaciones entre las conductas profesionales y tiempo de

  4. 药用唇柱苣苔叶片分化及植株再生研究%Research on Differentiation and Plant Regeneration From in Vitro Leaf Tissues of Chirita medica D.Fang ex W.T.Wang

    Institute of Scientific and Technical Information of China (English)

    姚绍嫦; 凌征柱; 李翠; 吕惠珍; 张占江

    2011-01-01

    目的:建立濒危药用植物药用唇柱苣苔叶片分化及植株再生体系.方法:以药用唇柱苣苔(Chirita medica D.Fang ex W.T.Wang)叶片为外植体,灭菌后接种到附加不同激素配比的培养基中培养,筛选各阶段合适的培养基.结果:不定芽诱导的最适培养基为MS+ 1.0 mg/L 6-BA+ 0.2 mg/L NAA,pH =6.0,诱导率为100%;最佳继代增殖培养基为MS+0.5 mg/L 6-BA+ 0.2 mg/L NAA,pH6.0,增殖系数为12.6/30 d;最适合的生根培养基为1/2 MS+ 0.2 mg/L NAA,pH=6.0,生根率高达100%,移栽成活率为95.0%.结论:本繁殖体系可在短时间内提供大量种苗,并为种质资源的保护和可持续利用提供技术指导.%Objective: To develop differentiation and plant regeneration system from in vitro leaf tissues of Chirita medica D. Fang ex W. T. Wang,an endangered medicinal species. Methods:The leaf of Chirita medica as explants were cultured on MS supplemented with different kinds and concentrations of hormone to select optimized different phase. Results;The optimum medium for adventitious buds induction and seedling regeneration was MS + 1.0 mg/L 6-BA + 0. 2 mg/L NAA (pH 6. 0) and the induce rate of bud regeneration was 100% . The efficient medium for high regeneration frequency was MS +0. 5 mg/L 6-BA +0. 2 mg/L NAA( pH 6.0) and the proliferation coefficient was 12. 6/30 d. The optimal rooting medium was 1/2 MS +0. 2 mg/L NAA(pH 6.0) and the rooting rate was 100% and the rate of transplanting survival was 95.0%. Conclusions; This system could be used to develop more seedlings in short time,and to provide guidance for conserving and sustainably developing the resource.

  5. Angiotensin II blockade, YKL-40 and maintenance of sinus rhythm after electrical cardioversion for atrial fibrillation

    DEFF Research Database (Denmark)

    Tveit, Arnljot; Seljeflot, Ingebjørg; Smith, Pal;

    2013-01-01

    cardioversion (ECV) for persistent AF and serum levels of YKL-40. A secondary point of interest was a potential effect of the angiotensin receptor blocker candesartan on YKL-40 levels. In the Candesartan in the Prevention of Relapsing Atrial Fibrillation (CAPRAF) study, 171 patients with persistent AF were...

  6. Neuroprotective effect of renin angiotensin system blockers on experimentally induced Alzheimer's disease in rats

    Directory of Open Access Journals (Sweden)

    Wafaa A. Hewedy

    2015-10-01

    Conclusions: This study reports that candesartan and perindopril can reverse the free radical induced damages and resultant memory defects, and may suggest candesartan as worthy drugs for prevention of Abeta-P deposition in this animal model of AD. [Int J Basic Clin Pharmacol 2015; 4(5.000: 853-859

  7. 《神农本草经》木香考%Textual research on Costus root (Aucklandia lappa Decne) in the Sheng nong ben cao jing (Shennong's Classic of Materia Medica)

    Institute of Scientific and Technical Information of China (English)

    李光燕; 王德群; 方士英; 徐茂红

    2014-01-01

    Aucklandia lappa Decne was first recorded in the Sheng nong ben cao jing (Shennong's Classic ofMateria Medica).Through the textual research of herbal literature,it was found that the costus root in the Sheng nong ben cao jing perhaps was not the plant of Aucklandia lappa Decne of Compositae,but the eaglewood or Lignum Aquilasria Resinatum based on the comprehensive judgment of shape,taste,nature,and function etc.In the Sheng nong ben cao jing,it only includes costus root without the title of eaglewood,and Tao Hongjing recorded both herbs together in his Ming yi bie lu (Supplementary Records of Celebrated Physicians),which became a foreshadow of misunderstanding of the later generations.Beginning from the Tang ben cao (Materia Medica of the Tang Dynasty),the costus root was considered as the plant of Auckiandia lappa Decne from the Compostae with its profound influence until now.%中药木香最早记载于《神农本草经》.通过考察多种本草文献,发现《神农本草经》中的木香可能不是现代菊科木香类植物,而是沉香,因为从形态、气味、功效等方面综合判断,沉香与《本神农草经》中的木香相吻合.《神农本草经》中只有“木香”,而无“沉香”,陶弘景将“木香”与“沉香”一并记载于《名医别录》中,为后人的误识埋下了伏笔.自《唐本草》始认为“木香”主要为菊科的木香类草本植物,这种认识一直影响至今.马兜铃科藤本青木香在《唐本草》和《本草图经》等本草著作的“木香”条中均有记载,但不做“木香”药用的主流.

  8. Xilazina como pré-medicação para anestesia com tiopental sódico em cães Xylazine as a pre-medicant for thiopental sodium anaesthesia in the dog

    Directory of Open Access Journals (Sweden)

    Orlando Ribeiro Prado Filho

    2000-06-01

    Full Text Available A xilazina produz um bom efeito sedativo-analgésico quando associado à drogas anestésicas. O tiopental sódico é um barbitúrico de curta duração que produz sonolência, sedação e hipnose. O objetivo deste trabalho é verificar a eficiência da associação da xilazina como pré-medicação e do tiopental sódico na manutenção da anestesia, em cães. Foram usados 32 cães sem raça definida, adultos, machos e com peso entre 8 e 10 kg, que foram submetidos à procedimento operatório no esôfago cervical. A dose média de xilazina administrada foi de 3,8 mg/kg e de tiopental sódico foi de 7,7 mg/kg. Não houve necessidade de intubação endotraqueal e não ocorreu óbito relacionado com as medicações anestésicas. Concluindo, o procedimento anestésico descrito é de fácil execução, é seguro e diminui o estresse do animal.The xylazine produce reliable sedative-analgesic effect when coadministered with anesthetics drugs. Thiopental sodium is a shorter duration barbituric, produced somnolence, sedation and hypnosis. The aim of this work is to verify the efficiency in association of xylazine and thiopental sodium to anesthesia in dogs. Thirty-two male mongrel dogs with an average weight between 8 and 10 kg were submitted to surgical procedure with approach of cervical aesophagus. The average dose was 3,8 mg/kg to xilazine and 7,7 mg/kg to thiopental sodium. Was not necessary endotracheal intubation and no deaths due anesthesic procedure were observed. The anesthesic procedure described is easy, safe and decreases the stress of the animal.

  9. 《神农本草经》对痹病的认识和治疗经验%Experience of treatment and understanding of impediment disease in Shen nong ben cao ring (Shennong's Classic of Materia Medica)

    Institute of Scientific and Technical Information of China (English)

    丁红昌; 王振瑞

    2015-01-01

    《神农本草经》是研究古代痹病史不可忽视的重要史料,书中所载365种药物中,与痹病相关的药物达75种,其中“湿痹”“寒湿痹”“风寒湿痹”“风痹”“风湿痹”“寒痹”涉及药物51种;“喉痹”“周痹”“血痹”涉及药物16种;“肉痹”“胃痹”“疝瘕痹”“消渴内痹”“痿痹”“偏痹”涉及药物8种.系统分析这些药物的性味、功效等相关知识,进而探寻当时医家对于痹病的整体认识和治疗经验,不仅可以丰富痹病的史学研究,而且可以为当代临床医生认识、治疗与“痹”相关的病症提供借鉴和参考.%As a book with significant historical materials for the research of impediment disease not to be ignored,Shen nong ben cao jing (Shennong's Classic of Materia Medica) contains,among its 365 kinds of materia medica,75 kinds of medicines related to impediment disease.Among the latter ones,51 are related to" damp impediment"," cold-damp impediment","wind-cold-damp impediment","wind impediment","wind-damp impediment",and" cold impediment"; 16 are related to "laryngeal impediment","general impediment",and "blood impediment" ; 8 are related to "muscular impediment","stomach impediment","hernia-conglomeration impediment","internal consumptive-thirst impediment","wilting impediment",and "hemiplegic impediment".To systematically analyze the properties,tastes,and effects of these medicines and its related knowledge,and then further explore the overall recognition and their treating experience of the physicians at that period would not only enrich the historical research on impediment disease,but also offer much help and reference to the understanding and treatment of impediment for contemporary clinicians.

  10. Medicações referentes às complicações após correção de aneurisma da aorta abdominal endovascular Medication in relation to complications after endovascular abdominal aortic aneurysm repair

    Directory of Open Access Journals (Sweden)

    Giel G. Koning

    2006-06-01

    Full Text Available OBJETIVO: Este estudo observacional foi desenvolvido para pesquisar a influência dos medicamentos na ocorrência de complicações após correção endovascular de aneurismas da aorta abdominal. MÉTODO: Foram analisados retrospectivamente os dados clínicos referentes a 70 pacientes consecutivos submetidos à correção endovascular de aneurisma da aorta abdominal em dois centros cirúrgicos vasculares num período de 3 anos. As complicações eram classificadas de acordo com as recomendações do Comitê Designado de Padrões de Tratamento. Foi feita uma distinção entre complicações relacionadas ou não ao stent. Uma análise de regressão foi usada para avaliar a associação entre 12 grupos de medicamentos diferentes e o resultado da correção endovascular. RESULTADOS: Durante um acompanhamento de 70 pacientes-anos, foram relatadas 14 complicações leves (20%, 23 moderadas (33% e sete graves (10%. Trinta pacientes (43% que usaram cumarínicos tiveram significantemente menos complicações não relacionadas ao stent (OR. 0,21; 95% CI 0,05-0,90 comparados com os não usuários. Vinte pacientes (29%, tomando medicamentos antieméticos durante internação, mostraram quatro vezes mais complicações relacionadas ao stent (OR. 4,37; 95% CI 1,10-17,3 e o uso de analgésicos no hospital em 25 pacientes foi associado com mais complicações relacionadas ao stent (OR. 3,81; 95% CI 1,32-11,0. CONCLUSÃO: Medicações parecem estar associados com a ocorrência de complicações após terapia endovascular de aneurismas da aorta abdominal. Pacientes que usaram cumarínicos tiveram menos complicações não relacionadas ao stent. Pacientes que usaram agentes antieméticos durante internação mostraram um número quatro vezes maior de complicações não relacionadas ao stent. Pacientes usando analgésicos durante a internação eram associados com maiores complicações relacionadas ao stent.OBJECTIVE: This observational study was undertaken to

  11. Importance of TCM Mindset Cultivation in the Education of Traditional Chinese Materia Medica Specialty at Agricultural and Forestry Universities%中医思维培养在农林院校中药专业教育中的重要性

    Institute of Scientific and Technical Information of China (English)

    史红专; 朱再标; 刘丽; 郭巧生; 王长林

    2014-01-01

    侧重于中药材生产的中药学相关专业的中医药基础课程培养目标和要求不同于传统中药学专业。本文从农林院校中药专业的教学目的、学生的生源、课程设置等角度着手,结合当前的教育体制和中医药学科特点,提出对农林院校中药专业学生进行中医思维培养的重要性。%The objective and request of course in Basis of traditional Chinese medicine (TCM)of Chinese materia medica relevant specialty which place emphasis on medicinal materials production differ from those of traditional Chinese materia medica specialty.In this review,we point out that it is of great importance for the students of Chinese materia medica specialty in agricultural and forestry universities to cultivate the TCM mindset,in the perspectives of teaching objectives,source of students,curriculum,and the present education system as well as the discipline characteristic of TCM.

  12. 知识网络图教学法在中药药理学教学中的运用%Application of knowledge network method in teaching pharmacology of Chinese materia medica

    Institute of Scientific and Technical Information of China (English)

    畅洪昇; 张硕峰; 孙文燕; 董世芬; 孙建宁

    2015-01-01

    针对中药药理学课程内容要素众多、教师教学困难、学生学习效果差的教学现状,本研究将知识网络图作为组织和设计课堂教学、教学效果评价的工具引入中药药理学的教学中。实践表明,该方法不仅可以突出教学内容的整体层次和内在关联,提高教学质量,而且可以激发学生对专业知识的学习兴趣,提高学生探索未知知识、完善知识结构的自主学习能力。%Aiming at the present teaching conditions, this paper attempted to apply knowledge network in the classroom teaching and teaching effectiveness evaluation of pharmacology of Chinese materia medica. Our practice shows that this method may help highlight overall level and internal relation of the teaching contents, improve teaching quality, stimulate students’interest in learning, and increase their self-dependent learning ability.

  13. Náttúruvörur. Möguleikar SagaMedica með íslensku náttúruvöruna SagaPro á Bretlandsmarkaði

    OpenAIRE

    Hekla Gunnarsdóttir 1973

    2012-01-01

    Markmið þessarar ritgerðar er að skoða stöðu náttúruvara í heiminum í dag og skoða hvaða möguleika íslenska náttúruvaran SagaPro, sem SagaMedica framleiðir, hefur á Bretlandsmarkaði. Fjallað er um kenningar um alþjóðavæðingu fyrirtækja og inngönguleiðir þeirra á erlenda markaði. Sérstaklega er fjallað um alþjóðavæðingu og inngönguleiðir lítilla og meðalstórra fyrirtækja og Born Global fyrirtækja. Skoðað er hvernig staða náttúruvara er í hverri heimsálfu fyrir sig en þó verður mest áhersla ...

  14. 参与式教学法在中药炮制学中的探索与实践%Exploration and Practice of Participation-Model Didactics on Processing Science of Chinese Materia Medica

    Institute of Scientific and Technical Information of China (English)

    王满元; 卢炜

    2014-01-01

    To assess the feasibility of the participation-model didactics on processing science of Chinese materia medica ,the effects of the teaching model were analysized and sumarized .The positive results verify the effectiveness of the didactics on developing students'creativity and improving their professional ability as well as transferable skills.Combination of participation-model didactics with traditional teaching model can help students improve their learning levels.%参与式教学法重视教学过程中“学”的因素,重视师生“对话”互动交流,有助于提高学生的综合能力与创新意识。该文归纳总结在中药炮制学课程中应用参与式教学的具体方法和实施途径。传统教学中加入参与式教学元素,两者有机结合,能够提高中药炮制学的教学质量。

  15. Caracterização dos idosos usuários de medicação residentes em instituição de longa permanência

    Directory of Open Access Journals (Sweden)

    Daiane Porto Gautério

    2012-12-01

    Full Text Available Os objetivos deste estudo foram caracterizar os idosos residentes em uma Instituição de Longa Permanência quanto ao uso de medicamentos e verificar a existência de polifarmácia. Trata-se de estudo descritivo e quantitativo, realizado por meio de dados de um banco originado da pesquisa Perfil de idosos residentes numa Instituição de Longa Permanência para Idosos (ILPIs: proposta de ação de enfermagem/saúde. Foram selecionados 39 idosos que faziam uso de medicação. Os achados evidenciaram predominância de mulheres, com idade entre 80 e 89 anos, que sabem ler e são viúvas. As doenças do aparelho circulatório foram as mais frequentes. Os idosos usavam em média 3,7 medicamentos e 30,8% deles utilizavam polifarmácia. Os medicamentos mais usados foram para as intercorrências do sistema cardiovascular. Verificou-se a presença de medicamentos considerados impróprios para idosos. Espera-se sensibilizar os profissionais de saúde a promoverem o uso racional e cuidadoso de medicamentos para os idosos institucionalizados.

  16. Construction of biopharmaceutics classification system of Chinese materia medica%多成分体系下中药生物药剂学分类系统的构建分析

    Institute of Scientific and Technical Information of China (English)

    刘洋; 隗丽; 董玲; 朱美玲; 唐明敏; 张雷

    2014-01-01

    基于中药的多成分特点,借鉴化药领域的生物药剂学分类系统(biopharmaceutics classification system,BCS)理念、方法和技术,提出了中药生物药剂学分类系统(biopharmaceutics classification system of Chinese materia medica,CMMBCS)的科学框架.在学术思想阐述和理论分析的同时,构建了基于多成分层次差异比较法和中药整体CMMBCS研究法的方法流程,明确了该系统用于揭示中药多成分吸收的相互影响及相关机制的基础性作用,也为提高中药质量标准和开发中药新药提供了新的思路和方法.

  17. 不同药剂处理对西瓜细菌性果斑病带菌种子的影响%Effects of Different Medicament Treatments on Watermelon Seeds Contaminated with Bacterial Fruit Blotch

    Institute of Scientific and Technical Information of China (English)

    牛庆伟; 孔秋生; 黄远; 别之龙

    2012-01-01

      Six different medicaments were used to soak watermelon seeds after the artificial inoculation of bacterial fruit blotch (BFB), and their control effects were evaluated by investigating the seed germination, seedling growth and incidence of BFB. The results showed that, it was effective to control BFB of watermelon seedlings by soaking seeds contaminated with BFB in 40%formaldehyde at a dilution of 100 times for an hour before sowing, and the control efficiency was 100%, moreover, the treatment had no detrimental effects on the seed germination and seedling growth of watermelon.%  采用菌悬浮液浸种方式对西瓜种子接菌,利用6种药剂对带菌种子进行浸种处理,并调查各处理对种子发芽、幼苗生长的影响及对西瓜幼苗细菌性果斑病(BFB)的防治效果。试验结果表明,播种前带菌种子采用40%甲醛100倍液浸种1 h,对西瓜幼苗BFB的防效达到100%,对西瓜种子的发芽和幼苗的生长无不良影响。

  18. Stress and its risk factors in medical students: An observational study from a medical college in India

    OpenAIRE

    Madhumita Nandi; Avijit Hazra; Sumantra Sarkar; Rakesh Mondal; Malay Kumar Ghosal

    2012-01-01

    Objectives: Stress in medical students is well established. It may affect academic performance and lead to anxiety, depression, substance abuse, and burnouts. There is limited data on stress in Indian medical students. We conducted an analytical observational study to assess the magnitude of stress and identify possible "stressors" in medical students of a teaching hospital in Kolkata. Materials And Methods: This questionnaire-based study was conducted in the Institute of Post Graduate Medica...

  19. Term Selecting Research on "Pharmaceutical Zoology and Botany" for the Revision of Chinese Traditional Medicine and Materia Medica Subject Headings%《中国中医药学主题词表》药用动植物学类主题词修订选词研究

    Institute of Scientific and Technical Information of China (English)

    朱玲; 刘静; 刘丽红; 董燕; 贾李蓉; 高博; 李海燕

    2015-01-01

    Objective To study term selecting principles and methods of subject terms in the class of"Pharmaceutical Zoology and Botany"for the new edition of TCM Materia Medica Subject Headings;To provide references for the revision.Methods Based on the compiling principles, word frequency of subject headings in TCM database were used as references. MeSH was referred to establish detail rules and regulations for revision of TB class.Results In TB class, 226 subject headings were planned to delete, such as "Apocynum Linn", "Piper betle Linn", "cetacean" and"dolphins";42 subject headings were planned to add, such as "Kalimerisindica", "Actinidiaceae" and "Squamata".Conclusion This revision formulated individual revision principles, proposed solutions for common problems, and basically completed adding and deleting of TB class and frame adjustment.%目的 研究《中国中医药学主题词表》药用动植物学类(TB类)主题词选词原则与方法,为其修订提供依据.方法 基于主题词表总体编制原则,以中国中医药数据库主题词标引词频为依据,参考医学主题词表(MeSH),确立TB类主题词修订细则.结果 本次修订拟删除罗布麻属、蒌叶胡椒、鲸目、海豚等226个主题词,拟增加马兰、猕猴桃科、有鳞目等42个主题词.结论 此次修订制定了药用动植物与中药类主题词结合考量等个性化修订原则,对常见问题提出了解决方案,基本完成原TB类主题词的增删及框架的调整.

  20. The Effects of Several Medicament Treats on Controlling the Empoasca Vitis and Its Natural Enemies%不同药剂对茶假眼小绿叶蝉的防效及其对天敌的影响

    Institute of Scientific and Technical Information of China (English)

    王蓉; 肖卫平; 郑松; 罗全丽; 韦青

    2013-01-01

    不同药剂防治茶假眼小绿叶蝉试验结果表明,烯啶虫胺10%水剂、印楝素0.3%乳油、联苯菊酯10%乳油、醚菊酯10%悬浮剂、吡虫啉70%水分散粒剂对茶假眼小绿叶蝉均具有较好的防效.印楝素0.3%乳油是植物源生物农药,缓效、低毒、不污染环境,烯啶虫胺10%水剂防效高,速效性和持效性较好,而且对捕食性天敌杀伤较小,可在无公害茶园推广应用.%The experimental results of several medicament control the empoasca vitis show that:10% Nitenpyram AS,0.3% Azadirachtin EC,10% Bifenthrin EC,10% Ethofenprox SC,70%Lmidacloprid WG have good control of the empoasca vitis.0.3% Azadirachtin EC is plant sources of biological pesticides,and it is slowly efficiency,low toxicity and no pollution; 10%Nitenpyram AS have high efficiency of controlling,persistence and readily available,and its damage is smaller to empoasca vitis's natural enemies,so it can promote and apply in nuisanceless tea gardens.

  1. 中药肝毒性与四气、五味及归经的相关性%Correlations between Hepatotoxicity and Four Properties,Five Tastes, Meridian Entry of Chinese Materia Medica

    Institute of Scientific and Technical Information of China (English)

    禄保平; 贾睿

    2012-01-01

    To analyze the correlations between hepatotoxicity and four properties;five tastes,meridian entry of Chinese materia medica. Chinese herbs with hepatotoxicity were regarded as the research objects, which were collected from published reports and monographs. The property theory of Chinese materia medica were referred to . The regularities of four properties, five tastes, arid meridian entry of Chinese herbs with hepatotoxicity, and the correlations between hepatotoxicity and property theory of Chinese materia medica were analyzed. ①The differences in terms of four properties of Chinese herbs with hepatotoxicity or general Chinese herbs were obvious(P <0. 05) , and the order from high to low was cold, warm, neutral, cool and hot, which was similar between two kinds of Chinese herbs. There was no correlation between hepatotoxicity and four properties; ②The difference in terms of five tastes of Chinese herbs with hepatotoxicity was obvious ( P < 0. 05) , and the order from high to low was bitter, acrid, sweet, sour, astringent, salty and bland. The difference in terms of five tastes of of general Chinese herbs was also obvious (P <0. 05) , and the order from high to low was bitter, sweet, acrid, salty, astringent, sour and bland. There existed some correlation between hepatotoxicity and five tastes ( P < 0. 05, rp = 0. 137 ) ;③The differences in terms of meridian entry of Chinese herbs with hepatotoxicity or general Chinese herbs were obvious(P <0. 05) , and the order from high to low was liver, lung,stomach, spleen, kidney, heart, large intestine, bladder, gallbladder, small intestine, pericardium and triple energizer meridian, which was similar between two kinds of Chinese herbs. There was no correlation between hepatotoxicity and meridian entry. The differences in terms of four properties, five tastes and meridian entry of Chinese herbs with hepatotoxicity are obvious. Comparied with general Chinese herbs, there is no correlation between hepatotoxicity and

  2. Dose evaluation in medical staff during diagnostics procedures in interventional radiology; Avaliacao da dose na equipe medica durante procedimentos diagnoticos de radiologia intervencionista

    Energy Technology Data Exchange (ETDEWEB)

    Bacchim Neto, Fernando A.; Alves, Allan F.F.; Rosa, Maria E.D.; Miranda, Jose R.A. [Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Botucatu, SP (Brazil). Instituto de Biociencias. Departamento de Fisica e Biofisica; Moura, Regina [Faculdade de Medicina de Botucatu, SP (Brazil). Departamento de Cirurgia e Ortopedia; Pina, Diana R., E-mail: bacchim@ibb.unesp.br [Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Botucatu, SP (Brazil). Faculdade de Medicina. Departamento de Doencas Tropicais e Diagnostico por Imagem

    2014-08-15

    Studies show that personal dosimeters may underestimate the dose values in interventional physicians, especially in extremities and crystalline. The objective of this work was to study the radiation exposure levels of medical staff in diagnostic interventional radiology procedures. For this purpose LiF:Mg,Ti (TLD-100) dosimeters were placed in different regions of the physician body. When comparing with reference dose levels, the maximum numbers of annual procedures were found. This information is essential to ensure the radiological protection of those professionals. (author)

  3. Analysis to inadvisable combination of Chinese material medica recordered in Chinese Pharmacopoeia 2005 edition and 2010 edition%中国药典2005版与2010版一部收载不宜同用中药分析

    Institute of Scientific and Technical Information of China (English)

    何春玲; 王晓燕; 李梅

    2011-01-01

    To investigate and analyze inadvisable combination of Chinese materia medica recorded in China Pharmacopeia 2005 edition and 2010 edition, and to provide convenience for physicians and pharmacists in clinical practice.%总结中国药典2005年版与2010年版一部不宜同用中药品种,并进行分析。为医生和药师方便查询该类药品临床使用注意事项提供方便。

  4. Avaliação da lidocaína tópica como pré-medicação para a endoscopia digestiva alta em crianças Evaluation of topical lidocaine spray as premedication to upper gastrointestinal endoscopy in children

    Directory of Open Access Journals (Sweden)

    Rodrigo Strehl Machado

    2009-12-01

    Full Text Available OBJETIVO: Avaliar a eficácia da lidocaína spray tópica como droga adjuvante na sedação e analgesia de crianças e adolescentes para endoscopia digestiva. MÉTODOS: Foram incluídos 80 pacientes (49 femininos e 31 masculinos, idade média 12±3 anos, 40 no grupo placebo e 40 no grupo lidocaína. Os pacientes foram alocados aleatoriamente e um paciente de cada grupo foi excluído. Lidocaína a 10% ou placebo (ácido tânico 0,5% aerossol (dois jatos foram aplicados na orofaringe antes da infusão de propofol. Os pacientes foram monitorizados durante o procedimento e após, sendo respondido questionário para avaliar odinofagia e a pré-medicação. O desfecho primário foi a dose de propofol empregada, enquanto os desfechos secundários foram incidência de complicações, tempo de sala e duração do procedimento. RESULTADOS: Não houve diferenças entre os grupos quanto à idade, sexo e indicação da endoscopia. A dose de propofol empregada não foi diferente nos dois grupos (grupo placebo 3,1±1,1 e grupo lidocaína 2,9±1,3mg/kg; p=0,69, mesmo quando considerada a dose bruta (p=0,33. No entanto, o tempo de sala médio foi maior no grupo placebo do que no lidocaína (23±7 versus 20±5 minutos; IC95% da diferença: 0,47-5,89 minutos, p=0,02. Não houve diferenças entre os grupos quanto à duração do procedimento, incidência de complicações e aceitação pelo paciente. CONCLUSÕES: O emprego de medicação tópica anestésica em endoscopia reduz o tempo de sala sem aumentar a incidência de efeitos adversos (NCT00521703.OBJECTIVE: This study aims to evaluate the efficacy of topical lidocaine as an adjuvant drug to sedatives in children and adolescents undergoing digestive endoscopies. METHODS: 80 patients (49 females and 31 males, 12±3 years old were randomly allocated into placebo (n=40 or lidocaine group (n=40. One patient was excluded from each group after allocation. Two puffs of either 10% lidocaine or placebo (tannic acid 0

  5. Dental pulp response to collagen and pulpotec cement as pulpotomy agents in primary dentition: A histological study

    Directory of Open Access Journals (Sweden)

    Pranitha Kakarla

    2013-01-01

    Full Text Available Introduction: As the search for a better biocompatible medicament is on, aim of the present study was to evaluate the pulpal response to collagen particles impregnated in antibiotics (Biofil TM -AB and new commercially available cement (Pulpotec that can be used as pulpal medicament. Materials and Methods: Total sample of 40 teeth from 20 children in the age group of 7-10 years which are noncarious having bilateral retained primary teeth were enrolled for the study. Nine teeth each were treated with collagen particles (group I and Pulpotec cement (group II, and the remaining samples were discarded due to various reasons. Both groups were randomly subdivided into three teeth each that were extracted after 7, 15, and 30 days intervals and examined histologically. Results: Moderate to severe inflammatory cells with newly formed blood vessels and disorganized odontoblastic cell layer was observed in group I after all three intervals with dentinal bridge formation in two specimens. On contrary, none of the specimens in group II showed any signs of inflammation, but there was a discontinuity in the odontoblastic layer lining along the dentin walls. Conclusion: Both materials were proven to be promising alternatives as pulp medicaments. However, collagen was found to be a better material.

  6. Applications of the Monte Carlo simulation in dosimetry and medical physics problems; Aplicaciones de la simulacion Monte Carlo en dosimetria y problemas de fisica medica

    Energy Technology Data Exchange (ETDEWEB)

    Rojas C, E. L., E-mail: leticia.rojas@inin.gob.m [ININ, Gerencia de Ciencias Ambientales, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2010-07-01

    At the present time the computers use to solve important problems extends to all the areas. These areas can be of social, economic, of engineering, of basic and applied science, etc. With and appropriate handling of computation programs and information can be carried out calculations and simulations of real models, to study them and to solve theoretical or application problems. The processes that contain random variables are susceptible of being approached with the Monte Carlo method. This is a numeric method that, thanks to the improvements in the processors of the computers, it can apply in many tasks more than what was made in the principles of their practical application (at the beginning of the decade of 1950). In this work the application of the Monte Carlo method will be approached in the simulation of the radiation interaction with the matter, to investigate dosimetric aspects of some problems that exist in the medical physics area. Also, contain an introduction about some historical data and some general concepts related with the Monte Carlo simulation are revised. (Author)

  7. Analysis on current situation of compound Chinese materia medica patent entried into China%进入中国的复方中药专利现状分析

    Institute of Scientific and Technical Information of China (English)

    许钧钧; 张辉; 唐力英; 吴宏伟

    2012-01-01

    为了解国外申请人在我国天然药物尤其是复方药物的专利布局特点,采用国家知识产权局自主开发的专利检索与服务系统(Patent Search and Service System of SIPO)的中国专利文摘数据库(CNABS),对1985-2012年5月的不同国家地区来源的专利申请进行检索,以国际专利分类表中涉及植物、藻类、苔藓、真菌等涵盖中药的分类号为检索目标,采用人工及软件辅助分析的方法对检索结果,尤其是中药复方专利进行多角度的分析(包括申请人、治疗领域、重点专利技术),以期掌握中药复方专利申请中的发展态势,并籍此分析国外复方专利技术的布局状况与技术发展路径,为国内专利制度下中药复方产业的长足发展提供参考.%In order to learn about the patent layout features of natural drugs, especially compound Chinese materia medica (CMM) patents in China applied by foreign applicants, the patent applications from the different countries during 1985-May, 2012 were searched and analyzed based on Patent Search and Service System of SIPO. The searches are targeted at the classification numbers of CMM, such as plant, algae, moss, fungi, in the international patent classification. The search results, particularly multi-angle analysis on compound CMM patents, including applicants, therapeutic field, and important patent technology, were analyzed by manpower and assistant software. The results could help us to know more about the development trend in the application of compound CMM patents on which the foreign situation and technology development path of patent medicine will be analyzed so as to provide a strategic value for the rapid development of CMM enterprises in China under the domestic patent system.

  8. Comparative evaluation of demineralization of radicular dentin with 17% ethylenediaminetetraacetic acid, 10% citric acid, and MTAD at different time intervals: An in vitro study

    OpenAIRE

    Kumar, Yogender; Lohar, Jitendra; Bhat, Sureka; Bhati, Manisha; Gandhi, Aanesh; Mehta, Abhishek

    2016-01-01

    Background: The smear layer has the capability to protect the bacteria within the dentinal tubules from intracanal medicament. After removal of the smear layer from infected root canals, it allows disinfection of the entire root canal. The smear layer compromising the seal between the root canal sealer and root canal wall also decreases the penetration of irrigants into dentinal tubules. Aims: This study compares the amount of phosphorous liberated and demineralization of the radicular dentin...

  9. 防制胚泡着床障碍中药的筛选及药效研究%Screen and Pharmacodynamic Action of Chinese Materia Medica for Prevention and Cure Embryo Implantation Dysfunction

    Institute of Scientific and Technical Information of China (English)

    王东升; 张世栋; 荔霞; 董书伟; 李世宏; 严作廷

    2012-01-01

    为了筛选防制胚泡着床障碍中药,本试验利用皮下注射米非司酮所致的小鼠胚泡着床障碍模型,以妊娠率、着床胚泡数、雌激素和孕激素及其比值为指标,将丹参、黄芪、川芎、黄芩、白术、菟丝子、桑寄生、续断、党参、当归等中药组成复方进行筛选和药效评价.筛选试验结果表明,方3组妊娠率显著高于方1组、菟丝子组和续断组(P<0.05),也高于方2组和对照组,说明方3有利于小鼠胚泡的着床.方3的药效试验表明,保胎组妊娠率极显著高于对照组和高剂量组(P<0.01),显著高于低剂量组(P<0.05).保胎组孕酮水平、孕酮和雌二醇比值极显著高于高、低剂量组、对照组和正常组(P<0.01),孕酮和雌二醇比值显著高于中剂量组(P<0.05),而保胎组、低剂量组和正常组雌二醇水平显著低于高剂量组和对照组(P<0.05),中剂量组孕酮水平显著高于对照组(P<0.05).这表明方3能提高小鼠的孕酮水平及孕酮和雌二醇比值,有利于小鼠胚泡着床.%To screen Chinese materia medica for prevention and cure embryo implantation dysfunction, mouse model with embryo implantation dysfunction was established by injected subcutaneously with mifepristone. Complex prescription composed of such Chinese materia medica as Salvia miltiorrhiza, Radix astragali, Szechwan lovage rhizome, Radix scutellariae, Rhizoma atractylodis macrocephalae , Semen cuscutae, Herba taxilli , Radix dipsaci, Radix codonopsis, Radix angelicae sinensis and some of them were evaluated in the model, pregnancy rate (PR), number of embryo implantation, progestin (P4), estradiol (E2) and ratio of progestin to estradiol (P4/E2) were the main index. The results of the screen test showed that PR was significantly higher in prescription 3 group than that in prescription 1 group, Semen cuscutae group and Radix dipsaci group (P<0. 05) , and was higher than those in the prescription 2 group and control group

  10. Le medicament du mois. Insuline glargine (Lantus).

    OpenAIRE

    Scheen, André

    2004-01-01

    Insulin glargine (Lantus) is a human insulin analogue produced by recombinant DNA technology and recently launched by Aventis. Modification of the human insulin molecule at position A21 and at the C-terminus of the B-chain results in the formation of a stable compound that is soluble at pH 4.0, but forms amorphous microprecipitates in subcutaneous tissue (pH > 7,4) from which small amounts of insulin glargine are gradually released. The plasma concentration versus time profile of insulin glar...

  11. Influência do choro e de padrões respiratórios na deposição de medicação inalatória em crianças The influence of crying and breathing pattern on inhalatory drug deposition in children

    Directory of Open Access Journals (Sweden)

    Camila Isabel da S. Santos

    2010-12-01

    Full Text Available OBJETIVO: Verificar a influência do choro e de padrões respiratórios na eficácia da terapia inalatória em crianças. FONTES DE DADOS: busca sistemática por artigos científicos referentes ao tema nas bases de dados Cochrane Controlled Trials Data Base, MedLine e Science Direct, publicadas no período de 1994 a 2009. Utilizaram-se os descritores: "choro", "inalação", "aerossol", "trabalho respiratório" e "criança", nos idiomas português e inglês. SÍNTESE DE DADOS: Foram selecionados 13 artigos, 12 em inglês e um em português. A maioria dos trabalhos apresenta os efeitos da terapia inalatória em crianças, sem discutir a influência do choro e de diferentes padrões respiratórios sobre a deposição da medicação. Estudos que fizeram essa relação verificaram que a respiração e, principalmente, o choro reduzem a quantidade de fármaco que chega às vias aéreas periféricas. Autores discutem as diferenças anatômicas e fisiológicas do sistema respiratório da criança que podem interferir na eficácia da terapia inalatória. Porém, a maioria deles não analisa a influência qualitativa e quantitativa dos padrões respiratórios e do choro sobre a mecânica pulmonar. CONCLUSÕES: O choro e os padrões respiratórios influenciam na terapia inalatória, sendo atribuída ao choro a redução significativa da deposição medicamentosa nas vias aéreas. Pouco se sabe sobre o princípio determinante para a alteração do potencial de deposição, pois são escassas as evidências sobre o tema, apesar de sua relevância no manejo de afecções pulmonares da população pediátrica.OBJECTIVE: To verify the influence of crying and breathing patterns in the effectiveness of inhalatory therapy in children. DATA SOURCES: Systematic search of scientific studies on the subject in the Cochrane Controlled Trials Database, MedLine and Science Direct, published from 1994 to 2009. The descriptors "crying", "inhalation", "aerosol", "work of

  12. Ação do anticonvulsivante isolado e associado ao midazolam como medicação pré-anestésica sobre o índice bispectral (BIS em pacientes com paralisa cerebral Acción del antiepiléptico aislado y asociado al midazolam como medicación preanestésica sobre el índice bispectral (BIS en pacientes con parálisis cerebral Effect of isolated anticonvulsant drug use and associated to midazolam as pre-anesthetic medication on the bispectral index (BIS in patients with cerebral palsy

    Directory of Open Access Journals (Sweden)

    Verônica Vieira da Costa

    2010-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Os pacientes com paralisia cerebral (PC frequentemente usam fármacos para tratamento de doenças concomitantes, como convulsões. O midazolam é o hipnótico mais utilizado como medicação pré-anestésica e suas interações medicamentosas nos pacientes com PC são desconhecidas. O objetivo deste estudo foi avaliar o midazolam como medicação pré-anestésica no BIS dos pacientes com PC em uso crônico de anticonvulsivantes. MÉTODO: Foram avaliados três grupos de pacientes: PC sem uso de anticonvulsivantes, PC em uso de anticonvulsivante e outro grupo sem doença e sem uso de medicações (Grupo Controle. Na véspera da cirurgia, com os pacientes despertos e em decúbito dorsal, foi colocado o monitor do BIS e foram registrados os valores basais do BIS. No dia seguinte, 40 minutos antes da cirurgia, os pacientes receberam 0,6 mg.kg-1 de midazolam por via oral. Antes do início da anestesia, foi realizado o mesmo procedimento para registro do BIS, após o uso do midazolam. RESULTADOS: Foram estudados 107 pacientes - 39 pacientes do Grupo Controle e 68 com diagnóstico de PC. Desses, 17 faziam uso de anticonvulsivante. Com relação ao valor médio de BIS após o uso do midazolam, não houve diferença entres os pacientes do Grupo Controle e do Grupo PC que não tomavam anticonvulsivante, enquanto entre os pacientes que faziam uso de anticonvulsivantes houve diferença (p = 0,003. A possibilidade de diminuição do BIS após o uso do midazolam aumenta de acordo com o número de anticonvulsivantes usados pelo paciente. CONCLUSÕES: O uso crônico de anticonvulsivante associado ao midazolam via oral como medicação pré-anestésica pode levar à diminuição dos valores de BIS, configurando níveis profundos de hipnose.JUSTIFICATIVA Y OBJETIVOS: Los pacientes con parálisis cerebral (PC, a menudo usan fármacos para el tratamiento de enfermedades concomitantes, como las convulsiones. El midazolam es el hipnótico m

  13. Caracterização dos idosos usuários de medicação residentes em instituição de longa permanência Caracterización de ancianos usuarios de medicación residentes en hogar geriátrico The characterization of elderly medication users living in long-term care facilities

    Directory of Open Access Journals (Sweden)

    Daiane Porto Gautério

    2012-12-01

    Full Text Available Os objetivos deste estudo foram caracterizar os idosos residentes em uma Instituição de Longa Permanência quanto ao uso de medicamentos e verificar a existência de polifarmácia. Trata-se de estudo descritivo e quantitativo, realizado por meio de dados de um banco originado da pesquisa Perfil de idosos residentes numa Instituição de Longa Permanência para Idosos (ILPIs: proposta de ação de enfermagem/saúde. Foram selecionados 39 idosos que faziam uso de medicação. Os achados evidenciaram predominância de mulheres, com idade entre 80 e 89 anos, que sabem ler e são viúvas. As doenças do aparelho circulatório foram as mais frequentes. Os idosos usavam em média 3,7 medicamentos e 30,8% deles utilizavam polifarmácia. Os medicamentos mais usados foram para as intercorrências do sistema cardiovascular. Verificou-se a presença de medicamentos considerados impróprios para idosos. Espera-se sensibilizar os profissionais de saúde a promoverem o uso racional e cuidadoso de medicamentos para os idosos institucionalizados.El estudio objetivó caracterizar a los ancianos residentes en un hogar geriátrico respecto del uso de medicamentos y verificar la existencia de polifarmacia. Estudio descriptivo, cuantitativo, utilizando banco de datos recopilados para la investigación Perfil de ancianos residentes en una residencia geriátrica (ILPI: propuesta de acción de enfermería/salud. Fueron seleccionados 39 ancianos usuarios de medicación. Los hallazgos evidencian predominancia de mujeres con edad entre 80-89 años, alfabetizadas y viudas. Las enfermedades del aparato circulatorio fueron las más frecuentes. Los ancianos utilizaban en promedio 3,7 medicamentos, 30,8% de ellos era usuario de polifarmacia. Los medicamentos de mayor utilización fueron aquellos para las complicaciones del sistema cardiovascular. Se verificó la presencia de medicamentos considerados improcedentes para ancianos. Se espera sensibilizar a los profesionales de

  14. Ocorrências adversas com medicação em Unidade de Terapia Intensiva: análise da administração de soluções hidroeletrolíticas e antibióticos Adverse occurences with drugs in Intensive Care Unit: analysis of the administration of electrolyte solutions and antibiotics

    Directory of Open Access Journals (Sweden)

    Simone Manenti

    1998-12-01

    Full Text Available O presente estudo teve por objetivos: 1 verificar a incidência de ocorrências adversas (OAs com medicação relacionadas ao tempo de infusão das soluções hidroeletrolíticas e ao número de doses de antibióticos prescritos e administrados aos pacientes; 2 caracterizar a natureza dessas ocorrências. A investigação foi realizada em duas UTIs de um hospital geral do Município de São Paulo. Fizeram parte do estudo os dados contidos nos prontuários de 51 pacientes que estiveram internados naquelas Unidades no mês de Agosto de 1996. Quanto à caracterização dos pacientes, 60% tinham idade acima de 60 anos, 58,8% eram mulheres, 49,1% permaneceram na UTI entre 1 e 5 dias e, ao saírem dela, 41,2 % foram para a Unidade de Cuidados Semi-Intensivos. Referente à incidência de 0As relacionadas ao tempo de administração das soluções hidroeletrolíticas e ao número de doses de antibióticos, constatou-se o não cumprimento das prescrições médicas dos pacientes, em 76,3% e 38,6%, respectivamente. A maior freqüência de irregularidades quanto aos soros (60,2% foi referente a administração em tempo menor que o prescrito (adiantamentos e, no caso dos antibióticos, a redução do número de doses (85%. Considerando-se tais irregularidades como ocorrências indesejáveis na prática da enfermagem na UTI, há que se investir na busca de medidas preventivas dessas ocorrências.The aims of this study were: 1 to verify the incidence of adverse occurences (AO with medication related to the time of electrolyte solutions infusion and the frequency of doses of antibiotics prescribed and administered to the patients; 2 to characterize the nature of those occurences. The study was developed in two ICUs of a general hospital of São Paulo City. The population was composed by 51 patients that were in the ICUs in August of 1996. Sixty percent of the patients were older than 60 years, 58,8% were women, 49,1% remained in ICU from 1 to 4 days and 41

  15. Randomized questionnaire based cross-sectional research study on awareness of sexually transmitted diseases amongst the general population between those who completed their high school education and those who have not

    OpenAIRE

    Narasimhalu, C.R.V.; Jegadeesan Muhilan

    2016-01-01

    Introduction: Sexually transmitted diseases (STDs) are a very important health challenge for adolescents. Educational level, especially sex education in school, prevents the adolescents falling prey to these diseases. Objective: To compare the awareness of STDs among general population with below and above high school qualification. Materials and Methods: A simple randomized, cross-sectional, questionnaire based study on the awareness of STDs on out-patients and in-patients of Saveetha Medica...

  16. Optimal design principle and method of inhaled composite particles for complex system of Chinese materia medica%面向中药复杂体系的吸入给药复合粒子优化设计原理与方法

    Institute of Scientific and Technical Information of China (English)

    郭立玮; 付廷明; 李玲娟

    2011-01-01

    鉴于中医药复杂巨系统求解过程在数学上的不可描述性,借鉴国内外先进的计算机化学与粉体材料科学理念与方法,以由水溶性和脂溶性两类物质组成的复方丹参制剂处方为模型药物,采集有效部位物料体系的物理化学特征参数(有关化学成分的熵、焓、表面能、电性等)、相关复合工艺特征参数(操作温度、搅拌速度、包覆时间等)及目的产物复合粒子性能特征参数(微结构参数与生物药剂学性能)等数据,建立中药复合粒子设计与制备工艺小型数据库,应用中药学、计算机化学、物理化学等跨学科交叉研究“中药粒子复合技术”的规律,探索中药复合粒子制备工艺微、纳米尺度有序组合机制,尝试以现代物理化学手段调控中药多元组分微结构及性能.为中药复方体系实现“表征参数检测一工艺过程参数筛选一目的产物性能优化”提供一种全新的研究模式.%Seeing that the complex giant system solving process of traditional Chinese medicine in mathematics is not descriptive and drawing on the advanced concepts of modern computer chemistry and materials science, Compound Danshen prescription consisting of both water-and fat-soluble substances was selected as a drug model to collect the physicochemical characteristic parameters of the effective part of material system (the chemical composition of the entropy, enthalpy, surface energy, and electricity, etc.), complex process-related characteristic parameters (operating temperature, stirring speed, and coating time, etc.), compound performance characteristic parameters of the product particle (micro-structural parameters and properties of biological agents), and other data, so as to establish a small database for the design and preparation of composite particles technology, study the regularity of "Chinese particle composite technology" by cross applying the knowledge of Chinese materia medica (CMM

  17. Estratégias para prevenção de erros na medicação no setor de emergência Estrategias para prevenir errores en la medicación en el sector de urgencia Strategies for prevention of medication errors in emergengy services

    Directory of Open Access Journals (Sweden)

    Regina Célia de Oliveira

    2005-08-01

    Full Text Available O estudo identificou as situações indicativas de erro ou quase erro na medicação através da análise das prescrições de medicamentos e evoluções de enfermagem. A partir dos dados obtidos foram implementados um ciclo de palestras e um curso sobre a segurança na administração de medicamentos para profissionais do setor de emergência de um hospital do nordeste. Os resultados revelaram que das 1.585 prescrições analisadas, 83,9% não explicitava a apresentação do medicamento e 84,6% a dose do medicamento. Dos medicamentos prescritos 34,2% apresentaram horários em que não havia registro da administração de medicamentos e 22,5% tinham o horário circulado. Dentre os medicamentos não-administrados 26% eram antibióticos e anticoagulantes; 15% analgésicos. As estratégias implementadas tiveram participação dos profissionais com bons índices de freqüência.El estudio identificó las situaciones indicadoras de errores o probables errores en la medicación, a de las prescripciones de medicamentos y fichas de evolución de enfermería. Además se llevó a cabo un ciclo de conferencias y un curso sobre seguridad en la administración de medicamentos, para los profesionales del Sector de Emergencia. Los resultados revelaron que de las 1.585 prescripciones analizadas, un 83,9% no expresaban con claridad la presentación del medicamento y un 84,6% la dosis del medicamento. De los medicamentos prescritos, un 34,2% no presentaban registro de la administración de los fármacos y un 22,5% tenían el horario circulado. Dentro de los medicamentos no administrados, un 26% eran antibióticos y anticoagulantes y un 15% analgésicos. Las estrategias implementadas tuvieron la participación de los profesionales, con buenos índices de frecuencia.This study identified situations indicating medication errors or near misses by analyzing medication orders and the nursing staff's performance. It also implemented a cycle of lectures and a course on

  18. Study of exfoliative dermatitis

    Directory of Open Access Journals (Sweden)

    Bharatiya P

    1995-01-01

    Full Text Available A study of 46 cases of exfoliative dermatitis revealed peak distribution in sixth decade and very high preponderance in males (M:F = 6.67 : 1. The highest single cause was found to be psoriasis (41.30%. Injudicious use of topical medicaments including herbal medicines and haphazard treatment were found to be the precipitating factors in 34% cases of pre-existing dermatoses. Laboratory investigations contributed little towards diagnosis except in lymphoma group; but were helpful in knowing systemic implications of the disease. Skin biopsy was found to be helpful in diagnosing underlying skin disorders in 18 cases (40.91%. Two cases (43.5% had malignancy as the cause of exfoliative dermatitis.

  19. Angiotensin Ⅱ receptor blocker provides pancreatic β-cell protection independent of blood pressure lowering in diabetic db/db mice

    Institute of Scientific and Technical Information of China (English)

    Jia-qing SHAO; Noseki IWASHITA; Hong DU; Yang-tian WANG; Yan-yan WANG; Ming ZHAO; Jian WANG; Hirotaka WATADA; Ryuzo KAWAMORI

    2007-01-01

    Aim: Several epidemiological studies have suggested that treatment with angiotensin Ⅱ type 1 receptor blocker provided a risk reduction of developing type 2 diabetes. The aim of this study was to investigate whether and how chronic candesartan treatment can attenuate the deleterious influence of the hyperactive local intra-islet renin-angiotensin system in the diabetes state. Methods: Eight-week-old db/db mice were randomized to candesartan 1 mg/kg, candesartan 10mg/kg, manidipine 10 mg/kg, or placebo via gavage for 6 weeks. Their age-matched nondiabetic littermates db/m mice were treated with placebo and acted as nondia-betic controls. After 6 weeks' treatment, an intraperitoneal glucose tolerance test, immunohistochemical staining of oxidative stress markers, insulin, CD31, azan staining and an electron microscopy observation were performed. Results: Chronic candesartan treatment provided an improvement of glucose tolerance, and greatly rescued islet β-cell mass. Candesartan treatment also notably decreased staining intensity of oxidative stress markers, as well as attenuating intra-islet fibrosis and improving blood supply in the islet. In the electron microscopy observation, candesartan-treated animals exhibited improved granulation and less remarkable endoplasmic reticulum and Golgi bodies; furthermore, candesartan treatment greatly relieved the swelling of mitochondria to nearly normal. Both the benefits of reducing oxidative stress and ultra structure protection were in a dose-dependent and blood pressure-independent manner. Conclusion: After diabetes was initiated, candesartan treatment could not reverse the state of diabetes, but it effectively improved glucose tolerance and protected β-cell function by attenuating oxidative stress, islet fibrosis, sparsity of blood supply and ultrastructure disruption in a dose-dependent and blood pressure-independent manner.

  20. Presentation of the project EPI-CT: A cohort study of children with substantial diagnostic medical exposure to ionizing radiation; Presentacion del proyecto EPI-CT: Estudio de cohorte de ninos con exposicion medica diagnostica substancia a radiaciones ionizantes

    Energy Technology Data Exchange (ETDEWEB)

    Bosch de Basea, M.; Cardis, E.; Vrijheid, M.

    2011-07-01

    Ionizing radiation for diagnostic purposes are an indispensable tool in modern medicine. The increasing use of computed tomography (CT) in children and adolescents is of concern both from the point of view of radio-protection and public health. children are more sensitive to the carcinogenic effects of ionizing radiation than adults. Children also have a higher life expectancy to show any detrimental effect. Furthermore, because of their smaller mass, CT scans in children receiving higher doses of radiation in specific organs in adults.

  1. HPLC测定中药成分溶度参数的理论与实验研究%Theoretical and experimental studies on solubility parameters of multiple components for traditional Chinese materia medica with HPLC

    Institute of Scientific and Technical Information of China (English)

    贺福元; 周宏灏; 罗杰英; 邓凯文; 扶瑾; 皮凤娟; 吴德智; 戴儒文

    2008-01-01

    目的:创立HPLC测定中药成分溶度参数的理论与方法.方法:运用色谱理论及Hildebrand-Scatehard溶解度理论创立HPLC法测定化合物的溶度参数的数学表达式,用已知溶度参数的咖啡因验证该理论并对大黄类成分进行测定.HPLC条件,色谱柱为Alltech Apoll C18柱(4.6 mm×250 mm,5μm);流动相为乙腈-水,梯度洗脱;检测波长咖啡因270 nm,大黄类成分254 nm;柱温25℃;进样体积10μL.结果:建立了保留时间与溶度参数关联的数学表达式,用此测得咖啡因的溶度参数为28.31 J1/2·cm-3/2,与文献28.84 J1/2·cm-3/2基本一致,用此法测得芦荟大黄素、大黄酸、大黄素、大黄素甲醚的溶度参数依次为39.70 J1/2·cm-3/2,39.08 J1/2·cm-3/2,38.37 J1/2·cm-3/2,36.42 J1/2·cm-3/2.结论:HPLC法能同时测定多个成分的溶度参数,这为研究中药的配伍溶解规律,单味中药剂改工艺研究奠定理论基础.

  2. A prospective study of calcium hydroxide intracanal medicament against endodontic interappointment emergency%氢氧化钙根管内封药预防根管治疗期间的急症

    Institute of Scientific and Technical Information of China (English)

    孙海花; 周明; 陈发明; 孙勇春

    2002-01-01

    目的探讨氢氧化钙(calcium hycroxide,CH)根管内封药对根管治疗期间急症(Endodontic interapp-ointment emergencies,IAE)的预防效果.方法对使用不同药物根管内封药IAE的发生率进行比较.结果 CMCP、PC、IPI、CH组IAE发生率分别是为22.0%、28.0%、26.0%和4.0%,有非常明显的差异,疼痛指数亦以CH组最低.结论 CH根管内封药,对IAE的发生有较好的预防作用.

  3. Survey of Current Experimental Studies of Effects of Traditional Chinese Medicine on Peripheral Nerve Regeneration

    Institute of Scientific and Technical Information of China (English)

    WU Qun-li; LIANG Xiao-chun

    2006-01-01

    The repairing and regeneration of peripheral nerves is a very complex biological and cytological process, its mechanism is unclear so far, and thus results in the lack of specific and effectual therapy and medicament. Chinese herbs and their effective components have their own inimitable predominance in promoting peripheral nerve regeneration, such as their multi-factorial, multi-target and multi-functional action, abundant source, inexpensive, etc. In this paper, the experimental studies reported in recent 5 years concerning the effects of Chinese herbs or their active components on peripheral nerve repairing and regeneration are reviewed in respects of the integral level, cellular level, molecular level and gene level.

  4. Influência da medicação pré-anestésica com midazolam e clonidina no nível de hipnose após indução anestésica com propofol e alfentanil em crianças: monitorização pelo índice bispectral

    Directory of Open Access Journals (Sweden)

    Eliana Marisa Ganem

    2002-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A medicação pré-anestésica (MPA é adjuvante da anestesia e diminui tanto a necessidade de concentrações elevadas de anestésicos como a ansiedade perioperatória, produzindo amnésia e contribuindo para estabilidade hemodinâmica. Dentre as drogas administradas na MPA de crianças, encontram-se o midazolam e a clonidina. O objetivo desta pesquisa foi avaliar se a MPA com midazolam e clonidina exerce influência no nível de hipnose, avaliado pelo BIS, em crianças após indução anestésica com propofol e alfentanil. MÉTODO: Participaram do estudo 30 pacientes, com idades entre 2 e 12 anos, estado físico ASA I, submetidos a cirurgias eletivas, que foram distribuídos em 3 grupos: G1 - sem MPA, G2 - midazolam (0,5 mg.kg-1 e G3 - clonidina (4 µg.kg-1, por via oral, 60 minutos antes da cirurgia. Todos os pacientes receberam alfentanil (30 µg.kg-1, propofol (3 mg.kg-1 e atracúrio (0,5 mg.kg-1. Avaliou-se o valor derivado do BIS antes da indução da anestesia (M1 e após a intubação (M2. O método estatístico utilizado foi a análise de variância para idade, peso e altura, e análise de perfil para o BIS, sendo o valor de p < 0,05 considerado significativo. RESULTADOS: Quando se comparou o mesmo momento (M1 ou M2 entre os três grupos, não foram observadas diferenças estatisticamente significativas. Quando se compararam os dois momentos de um mesmo grupo, M1 foi maior que M2 nos três grupos. CONCLUSÕES: A medicação pré-anestésica com midazolam e clonidina não influenciou o nível de hipnose em crianças induzidas com propofol e alfentanil.

  5. Study on the irradiation decontamination of traditional Chinese medicines

    International Nuclear Information System (INIS)

    Traditional Chinese Medicines (TCMs) are natural products prepared from plants, minerals and animals, it is easy for contamination by microorganisms to occur; thus causing problems in complying with the requirements laid down for passing microbial limit tests. We selected some kinds of TCMs, including unprocessed materia medica, traditional Chinese patent medicine (TCPMs) and chemical constituents for irradiation by 60Co gamma ray and investigating the results in terms of microbiology, chemistry, pharmacology and toxicology. We found no evidence of changes in most of the tested items, which indicates that the irradiation method could be employed for decontamination of TCMs. However, some chemical constituents of unprocessed materia medica, such as gentiopicrin in Radix Gentianae Macrophyllae and 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside in Radix Polygoni Multiflori, decomposed when these crude materials were irradiated with dose of 5kGy. Further study revealed that although the medicinal were altered by irradiation, the monomers of some of these chemical constituents were not affected. In addition to investigation of the items described above, the doses of irradiation were selected experimentally to ensure that, after irradiation, the TCMs passed the microbial limit tests described in the Chinese Pharmacopoeia. The lowest possible doses were used in order to avoid any impairment of the quality and clinical efficacy of the effective ingredients of the TCMs. (author)

  6. Impacts of multicomponent environment on solubility of puerarin in biopharmaceutics classification system of Chinese materia medica%中药生物药剂学分类系统中多成分环境对葛根素溶解度的影响

    Institute of Scientific and Technical Information of China (English)

    侯成波; 汪国鹏; 张强; 杨文宁; 吕贝然; 隗丽; 董玲

    2014-01-01

    该研究针对中药生物药剂学分类系统(biopharmaceutics classification system of Chinese materia medica,CMMBCS)中的溶解度问题,实验考察人工制造的多成分环境对溶解度的影响,并利用所获数据进行数学建模总结相关规律.实验采用递进式设计,分别研究了单一成分背景(黄芩苷、小檗碱和甘草酸)、两成分背景(黄芩苷+甘草酸、黄芩苷+小檗碱和甘草酸+小檗碱)和三成分背景(黄芩苷+甘草酸+小檗碱)对葛根素溶解度影响的变化趋势,从而建立多成分环境对葛根素溶解度影响的数学回归模型方程.

  7. Effects of exercising on ET-1 in plasma and tissue fluid of vitiligo patients undergoing medicament treatment%运动对药物治疗白癜风患者血浆及组织液内皮素-1的影响

    Institute of Scientific and Technical Information of China (English)

    刘福泉; 王松涛; 刘忠海

    2014-01-01

    In order to probe into the effects of exercising of different intensities combined with medicament treat-ment on the area of skin lesion areas and ET-1 in plasma and tissue fluid of vitiligo patients, the authors selected 45 vitiligo patients and divided them randomly into 3 groups:a calm control (pure medicament) group, a medium in-tensity exercising (medium intensity exercising + medicament treatment) group, and a high intensity exercising (high intensity exercising+medicament treatment) group (each group included 15 patients), let the patients in the medium intensity exercising group run for 1 hour per time, at an exercising intensity that maintained the heart rate at 120-140 beats/min, let the patients in the high intensity exercising group do a rope skipping exercise for accumula-tively 1 hour per day and maintain their average heat rate at 160-170 beats/min during exercising, let the patients in the two exercising groups exercise for totally 16 weeks, 5 days per week, drew the patients’ blood and tissue fluid before and after 16-week exercising intervention, measured ET-1 mass concentration by applying radioimmunoas-say, determined the changing of copper ions by measuring trace elements in plasma, checked the changing of collat-eral blood vessels and vessel diameters by means of extremity vascular microcirculation, and revealed the following findings: 1)exercising increased ET-1 mass concentration in plasma and tissue fluid significantly, the patients in the high intensity exercising group had the most significant increase;2)before and after 16-week exercising, the patients in calm control group and the two exercising groups had an increased number of serum copper ions, the patients in the calm control group had a significant increase, while the patients in the exercising groups had only a slight increase;3)long term regular exercising increased the patients’ collateral blood vessels and vessel diameters, boosted blood cir-culation;4)After the experiment

  8. Communication Impairments in Early Term and Late Preterm Children: A Prospective Cohort Study following Children to Age 36 Months

    OpenAIRE

    Stene-Larsen, Kim; Brandlistuen, Ragnhild Eek; Lang, Astri M; Landolt, Markus A; Latal, Beatrice; Vollrath, Margarete E.

    2014-01-01

    OBJECTIVE To investigate the risk of communication impairments at age 18 and 36 months in children born early term (gestational weeks 37-38) and late preterm (gestational weeks 34-36). STUDY DESIGN A total of 39 423 children and their mothers participated in the Norwegian Mother and Child Cohort Study. The sample included 7109 children (18%) born early term and 1673 (4.2%) born late preterm. Information on gestational age and prenatal and postnatal risk factors was obtained from the Medica...

  9. 中药生物药剂学分类系统中多成分环境对葛根素渗透性的影响%Effect of multicomponent environment on intestinal permeability of puerarin in biopharmaceutics classification system of Chinese materia medica

    Institute of Scientific and Technical Information of China (English)

    刘洋; 王刚; 董玲; 唐明敏; 朱美玲; 董红环; 侯成波

    2014-01-01

    中药生物药剂学分类系统(biopharmaceutics classification system of Chinese materia medica,CMMBCS)中的渗透性评价,需多成分作为整体来开展研究,即使在研究具体某一成分时,也应将其放在多成分环境中审视.该实验以此为原则,将葛根芩连汤中的高含量成分作为多成分环境影响因素,考察葛根素的肠渗透性,运用在体肠单向灌流模型,对葛根素肠渗透性的相关参数进行测定,评价其他高含量成分对其肠渗透性的影响.实验结果表明不同比例的黄芩苷、甘草酸和小檗碱对葛根素的肠渗透性均有一定的影响,甘草酸能显著抑制葛根素的肠吸收,高浓度小檗碱会促进葛根素的吸收.该研究结果表明中药生物药剂学分类系统的渗透性评价充分考虑多成分环境中其他成分的影响是重要的研究思想.

  10. Clinical Study on Treatment of Infantile Rotaviral Enteritis with Guava Leaf

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    [1]Thillainayagam AV, Dias JA, Salim AFM, et al. Glucose polymer in the fluid therapy of acute diarrhea: studies in a model of rotavirus infection in neonatal rats. Clin Sci 1994;86∶460-477.[2]Haffejec IE. The epidemiology of rotavirus infections: A global perspective. J Pediatric Gastroenterology and Nutrition 1995;20∶275-286.[3]WEI LB, LU RH, CHEN BT. The effect of guava leaf in antagonizing rotavirus in vitro. World Chinese J Digestion 1999;7(1)∶895-897.[4]Ministry of Health of PRC. Guidance on Principle of Clinical Research of Chinese New Drugs. 1st ed. Beijing: 1993,126-128, 227-229.[5]LI JL, LU JB, CHEN FL. Thin layer scanning of guaijaverin in guava leaf. J Chinese Materia Medica 1999,24(suppl)∶24-25.[6]LI JL, LU JB, CHEN FL. Analysis of volatile oil in gauva leaf by GC-MS. J Chinese Materia Medica 1999;22(2)∶79-80.[7]Paul A. Host factor associated with protection against rotavirus disease: The skies are clearing. J of Infectious Dis 1996;174(suppl)∶59-64.

  11. Role of candesartan against cerebral ischemia and oxidative damage in normotensive rats

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Objective Angiotensin Ⅱ(Ang Ⅱ)contributes to modulating blood pressure by stimulation of Ang Ⅱ AT1 receptors.We devised a rat transient middle cerebral artery occlusion(MCAO)model to assess whether oxidative damage is decreased after pretreatment with Angiotensin Ⅱ AT1 receptor blocker(ARB).Methods After 2 weeks pretreatment with ARB 0.5 and 1mg/kg,the male Wister rats were subjected to 2h middle cerebral artery occlusion(MCAO).At 24h,the lumen diameter of middle cerebral artery,the plasma level of 8-hydrox...

  12. Effect of candesartan on microalbuminuria and albumin excretion rate in diabetes: three randomized trials

    DEFF Research Database (Denmark)

    Bilous, Rudy; Chaturvedi, Nish; Sjølie, Anne Katrin;

    2009-01-01

    BACKGROUND: Microalbuminuria in diabetes is strongly predictive of nephropathy, end-stage renal disease, and premature cardiovascular morbidity and mortality. Effective preventive therapies are therefore a clinical priority. OBJECTIVE: To determine whether the angiotensin-receptor blocker candesa...

  13. Formulation development and release studies of indomethacin suppositories

    Directory of Open Access Journals (Sweden)

    Sah M

    2008-01-01

    Full Text Available Indomethacin suppositories were prepared by using water-soluble and oil soluble suppository bases, and evaluated for in vitro release by USP I and modified continuous flow through bead bed apparatus. Effect of the Tween 80 (1% and 5% was further studied on in vitro release of the medicament. Release rate was good in water-soluble suppositories bases in comparison to oil soluble suppositories bases. Release was found to be greater in modified continuous flow through bead bed apparatus. When surfactant was used in low concentration then release rate was much greater, as compared to high concentration. When stability studies were performed on the prepared indomethacin suppositories it was found that suppositories made by water-soluble base had no significant changes while suppositories prepared by oil soluble bases, had some signs of instability.

  14. PHYTOCHEMICAL AND PHARMACOGNOSTICAL STUDIES ON PEDALLIUM MUREX LINN

    Directory of Open Access Journals (Sweden)

    A.R. Mulaicharam

    2011-02-01

    Full Text Available Pedallium Murex Linn (entire plant (Pedaliaceae, a plant of immense medicinal values was taken for the present study. It is essential to ensure the quality and purity of the popular fragrance plant. The entire plant of Pedallium Murex Linn was subjected to various Pharmacognostical evaluations like Morphological, Microscopical and Powder analysis. Results have revealed clearly that the entire plant is genuine. The Phytochemical constituents of Leaves of Pedallium Murex Linn have been worked out. The dry powder of the entire plant was successfully extracted with Total Petroleum ether extract, Alcohol Extract, Chloroform extract, and Aqueous Extract. All the extracts were subjected to Preliminary Phytochemical screening. It showed the presence of Carbohydrates, Glycosides, Alkaloids, Steroids and Flavonoids. As per Materia medica (Krithikar and Basu, studies are required for the screening of various Pharmacological activities like plant pacifies vitiated vata, pitta, urinary retention, kidney stone, seminal weakness, amenorrhea, inflammation, flatulence and fever.

  15. Overuse of symptomatic medications among chronic (transformed) migraine patients: profile of drug consumption Uso excessivo de medicações sintomáticas em pacientes com migrânea crônica (transformada): perfil de consumo medicamentoso

    OpenAIRE

    Abouch Valenty Krymchantowski

    2003-01-01

    Chronic daily headache and chronic (transformed) migraine (TM) patients represent more than one third of the subjects seen in specialized headache centers. Most of these patients may overuse symptomatic medications (SM) taken on a daily basis to relieve headache and associated symptoms. The conversion to the daily or near-daily pattern of headache presentation is thought to be related to the medication overuse. The aim of this study was to evaluate the profile of SM consumption among transfor...

  16. Dose evaluation due to the effluent liberation by medical installations at city of Rio de Janeiro, Brazil; Avaliacao de doses devido a liberacao de efluentes por instalacoes medicas na cidade do Rio de Janeiro

    Energy Technology Data Exchange (ETDEWEB)

    Shu, Jane; Rochedo, Elaine R.R., E-mail: jshu@cnen.gov.b, E-mail: erochedo@cnen.gov.b [Comissao Nacional de Energia Nuclear (CODIN/CNEN), Rio de Janeiro, RJ (Brazil). Coordenacao de Instalacoes Nucleares; Heilbron, Paulo F.L., E-mail: paulo@cnen.gov.b [Comissao Nacional de Energia Nuclear (COREJ/CNEN), Rio de Janeiro, RJ (Brazil). Coordenacao de Rejeitos; Crispim, Verginia R., E-mail: verginia@con.ufrj.b [Coordenacao dos Programas de Pos-Graduacao de Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear

    2011-10-26

    This paper, the city of Rio de Janeiro was taken as a case study. It was processed deterministic and probabilistic simulations vor evaluation of the dose in two exposure sceneries, one of them referring to public members exposure and the other relative to exposure of sewage sanitary treatment plant workers. The results showed that at present the doses for inhabitants of the city and operators of treatment station are lower to dose limit established for the public, the approach presently in use in Brazil is not sufficient to accomplish whit international requirements and the regulation should be revised to be adopted specific values for each radionuclide

  17. Effect of gamma irradiation on mechanical and thermal properties of DGEBA/cycloaliphatic amine networks with potential for medical applications; Efeito da irradiacao gama nas propriedades mecanicas e termicas de redes DGEBA/amina cicloalifatica com potencial para aplicacoes medicas

    Energy Technology Data Exchange (ETDEWEB)

    Neves, Juliana C.; Silva, Glaura G., E-mail: glaura@qui.ufmg.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil); Mendes, Marcio W. Duarte; Bressiani, Ana H.; Bressiani, Jose C. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Garcia, Filiberto Gonzalez [Universidade Federal de Itajuba (UNIFEI), MG (Brazil)

    2013-07-01

    Two epoxy polymers based on diglycidyl ether of bisphenol A (DGEBA), cured with piperidine (Pip) and 4,4'-diamino-3,3'-dimethyldicyclohexylmethane (3DCM), were characterized before and after treatment with γ irradiation. The changes in the mechanical and thermal properties were studied by elastic modulus, glass transition temperature and degradation temperature measurements. A dose of 50 kGy of irradiation caused subtle variations in properties such as rigidity and stability, which are relevant from the fundamental point of view. The variations do not imply on negative impact when considering the stage of sterilization during the use of these systems as a biomaterial in the medical area. (author)

  18. 不同药剂及基质对辣木种子萌发及幼苗生长的影响%Impact of Different Medicaments and Substrates on Seed Germination and Growth of Moringa oleifera

    Institute of Scientific and Technical Information of China (English)

    陈鸿洁; 钱云; 李涛; 陈伟强

    2015-01-01

    针对河口地区在生产上辣木育苗过程中出苗率过低的问题,采取不同种子处理措施及基质处理方法进行播种育苗试验,结果表明:100 mg/L的高锰酸钾溶液和1%多菌灵溶液的出苗率低于直接用冷水浸泡种子,不同药剂对幼苗的生长状况影响差异不显著;纯河沙处理的出苗率最高,幼苗在沙床上的长势最好,株高与茎围均优于其它基质。研究结果对辣木的播种育苗具有一定的指导意义。%On the production of Moringa seedling germination rate is too low in Hekou, in the process of this study has taken a different seed treatment and substrate treatment method for test.The results showed that:the germination rate of 100mg/L KMnO4 solution and 1% carbendazim solution are lower than cold water. Different reagents influence on seedling growth status difference was not significant; Sand processing to the highest germination number, seedling in sand bed do best, plant height and stem circumference were superior to other substrates. The study result has a certain guiding significance of seeding.

  19. Comorbidities, medications and depressive symptoms in patients with restless legs syndrome and migraine Comorbidades, medicações e sintomas depressivos em pacientes com síndrome das pernas inquietas e enxaqueca

    Directory of Open Access Journals (Sweden)

    Karen S. Ferreira

    2013-02-01

    Full Text Available OBJECTIVE: The pathophysiology of migraine and restless legs syndrome (RLS seems to involve inherited mechanism and dysfunction of the dopaminergic system. Previous articles have shown that the frequency of RLS is higher in migraine patients than in controls. We conducted a study to evaluate comorbidities, medication used and depressive symptoms that can explain the relation between migraine and RLS. METHODS: A case-control study was performed in which patients with migraine (n=72 and a control group without migraine (n=72 were interviewed. Data including RLS diagnosis, depressive symptoms, comorbidities and drugs used were evaluated. RESULTS: There was a significant association between migraine and RLS (p=0.01, but comorbidities such as diabetes, hypertension, anemia and drugs used did not explain this association. Depression scores, as measured by the Beck Depression Inventory, were higher in migraine patients with RLS (p =0.04. CONCLUSION: No specific factors explaining the association between migraine and RLS were found. Symptoms of depression were more frequent in patients with migraine and RLS.OBJETIVO: A fisiopatologia da enxaqueca e da síndrome das pernas inquietas (SPI parece envolver mecanismos genéticos e disfunção do sistema dopaminérgico. Artigos anteriores mostraram que a frequência de SPI em pacientes com enxaqueca é maior do que nos controles. Desenvolvemos um estudo para avaliar comorbidades, medicamentos utilizados e sintomas depressivos em pacientes com migrânea e SPI. MÉTODOS: Foi desenvolvido um estudo de caso-controle. Foram entrevistados pacientes com enxaqueca (n=72 e sujeitos de um grupo controle (n=72. Foram avaliados dados incluindo diagnóstico de SPI, sintomas depressivos, comorbidades e medicamentos usados. RESULTADOS: Houve associação significativa entre enxaqueca e SPI (p=0,01. Comorbidades como diabetes, hipertensão, anemia ou drogas utilizadas não explicam esta associação. Escores de depress

  20. Evaluation of the single radiosensitivity in patients subjected to medical exposure that show severe skin reactions; Evaluacion de la radiosensibilidad individual en pacientes sometidos a exposiciones medicas que manifiestan reacciones cutaneas severas

    Energy Technology Data Exchange (ETDEWEB)

    Di Giorgio, M.; Vallerga, M.B. [Laboratorio de Dosimetria Biologica, Autoridad Regulatoria Nuclear, Av. Del Libertador 8250 (C1429BNP), Buenos Aires (Argentina); Portas, M. [Hospital de Quemados del Gobierno de la Ciudad de Buenos Aires (Argentina); Perez, M.R. [Laboratorio de Radiopatologia, Autoridad Regulatoria Nuclear, Buenos Aires (Argentina)]. e-mail: mdigiorg@cae.arn.gov.ar

    2006-07-01

    The Burnt Hospital of the Buenos Aires City Government (HQGCBA) it is a hospital of reference of the Net of Medical Responses in Radiological Emergencies of the Argentine Republic. In the mark of an agreement among the HQGCBA and the Authority Regulatory Nuclear (ARN), it is in execution a study protocol for the one boarding diagnoses and therapeutic of radioinduced cutaneous leisure. They exist individual variations that can condition the response to the ionizing radiations (IR), so much in accidental exposures as having programmed (radiotherapy, radiology interventionist). In this context, the individual radiosensitivity is evaluated in the patients signed up in this protocol that presented sharp or late cutaneous reactions, with grades of severity 3-4 (approaches EORTC/RTOG). The capacity of repair of the DNA was evaluated in outlying blood lymphocytes irradiated in vitro (2 Gy, gamma of Co-60) by means of the micronucleus techniques and comet essay in alkaline conditions. In this work two cases in those that is applied this study protocol, the therapeutic answer and its correlate with the discoveries of the radiosensitivity tests is presented. Case 1: patient of feminine sex, subjected to external radiotherapy by a breast infiltrating ductal carcinoma; developed sharp cutaneous radiotoxicity grade 3 (confluent humid epithelitis) that motivate the interruption of the treatment. Case 2: patient of masculine sex, subjected to a coronary angioplasty (interventionist radiology); developed late cutaneous radiotoxicity grade 4 (ulceration in dorsal region). Both patients were treated with topical trolamine associated to systemic administration of pentoxiphiline and antioxidants. The therapeutic answer is evaluated by means of clinical pursuit, photographic serial register and complementary exams (thermography and ultrasonography of high frequency). In the case 1 the answer was very favorable, with precocious local improvement and complete remission of symptoms and

  1. Comorbidities, medications and depressive symptoms in patients with restless legs syndrome and migraine Comorbidades, medicações e sintomas depressivos em pacientes com síndrome das pernas inquietas e enxaqueca

    Directory of Open Access Journals (Sweden)

    Karen S. Ferreira

    2013-01-01

    Full Text Available OBJECTIVE: The pathophysiology of migraine and restless legs syndrome (RLS seems to involve inherited mechanism and dysfunction of the dopaminergic system. Previous articles have shown that the frequency of RLS is higher in migraine patients than in controls. We conducted a study to evaluate comorbidities, medication used and depressive symptoms that can explain the relation between migraine and RLS. METHODS: A case-control study was performed in which patients with migraine (n=72 and a control group without migraine (n=72 were interviewed. Data including RLS diagnosis, depressive symptoms, comorbidities and drugs used were evaluated. RESULTS: There was a significant association between migraine and RLS (p=0.01, but comorbidities such as diabetes, hypertension, anemia and drugs used did not explain this association. Depression scores, as measured by the Beck Depression Inventory, were higher in migraine patients with RLS (p =0.04. CONCLUSION: No specific factors explaining the association between migraine and RLS were found. Symptoms of depression were more frequent in patients with migraine and RLS.OBJETIVO: A fisiopatologia da enxaqueca e da síndrome das pernas inquietas (SPI parece envolver mecanismos genéticos e disfunção do sistema dopaminérgico. Artigos anteriores mostraram que a frequência de SPI em pacientes com enxaqueca é maior do que nos controles. Desenvolvemos um estudo para avaliar comorbidades, medicamentos utilizados e sintomas depressivos em pacientes com migrânea e SPI. MÉTODOS: Foi desenvolvido um estudo de caso-controle. Foram entrevistados pacientes com enxaqueca (n=72 e sujeitos de um grupo controle (n=72. Foram avaliados dados incluindo diagnóstico de SPI, sintomas depressivos, comorbidades e medicamentos usados. RESULTADOS: Houve associação significativa entre enxaqueca e SPI (p=0,01. Comorbidades como diabetes, hipertensão, anemia ou drogas utilizadas não explicam esta associação. Escores de depress

  2. Significant demand and key problems of membrane science and technology applying to pharmaceutical industry of Chinese materia medica%中药制药工业对膜科学技术的重大需求与关键问题

    Institute of Scientific and Technical Information of China (English)

    郭立玮

    2009-01-01

    To discuss the significant application for the membrane science and technology in the development of pharmaceutical industry of Chinese materia medica(CMM)in such aspects as obtaination of integrated effctive substances,transformation of traditional technology,reduction of power consumption,product safety,sewage treatment,and technological innovation.To analyze the major restrictions on the industrialization of CMM'S membrane science and propose the corresponding measures.Currently,the development of macromolecule science and technology and the implementation of environmental-friendly strategy have advanced the technology of membrane to a new stage and thus offer the insurance to the integration of extraction,separation,concentration,and purification in traditional pharmaceutical production of CMM.Meanwhile,the technolgy of membrane separation has been widely used in the separation,concentration,and purification of macromolecule,which bears similar characteristics with traditional CMM.It is also a proof that the technology of membrane will improve the efficency of traditional CMM production when it is used in the pharmaceutical industry of CMM.%论述了中药制药工业在获取中药整体药效物质、改造传统工艺、降低能耗、保障产品安全、污水处理、技术创新等方面对膜科学技术的重大需求.分析了制约中药膜分离技术产业化进程的关键问题,并提出相应对策.当前高分子科学和分析技术的进展以及环境友好战略的实施使膜技术步入了快速发展的新阶段,从而为中药生产的提取、分离、浓缩、纯化一体化工程技术的解决提供了保证.同时膜分离技术在与中药体系特性接近的生物大分子的分离、浓缩和纯化上所得到的广泛应用,也从一个侧面说明膜技术如果用于中药生产,应当同样会获得较高的效益.

  3. 中药生物药剂学分类系统的多成分溶出评价方法在葛根芩连片中的应用%Application of multicomponent dissolution evaluation method of biopharmaceutics classification system of Chinese materia medica in Gegen Qinlian tablets

    Institute of Scientific and Technical Information of China (English)

    隗丽; 汪国鹏; 董玲; 唐明敏; 张雷; 朱美玲; 刘洋

    2014-01-01

    该研究是中药生物药剂学分类系统(biopharmaceutics classification system of Chinese materia medica,CMMBCS)用于中成药评价的实例,重点评估可能影响多成分吸收时序的溶出同步性问题.实验采用HPLC测定复方葛根芩连片中9种成分在不同溶出介质中不同时间点的累积溶出百分率,绘制体外溶出曲线,采用相似因子(f2)和聚类分析进行溶出曲线的相似性比较分析,结果表明在水介质中,峰7和峰8(黄芩苷)所代表的成分与2号参比峰(葛根素)相似性较差,相似因子均为43;在pH7.4介质中,峰7和峰8(黄芩苷)所代表的成分与2号参比峰(葛根素)相似性较差,相似因子分别为31和45;其他介质中各峰所代表的成分与2号参比峰(葛根素)均相似性较好.该实验表明峰3,4,5和6(小檗碱)所代表的成分与2号参比峰(葛根素)具有完全同步溶出的特性;峰1和峰9所代表的成分与2号参比峰(葛根素)具有基本完全同步溶出的特性;峰7和峰8(黄芩苷)所代表的成分与2号参比峰(葛根素)不具有同步溶出的特性.

  4. Main radiation protection actions for medical personnel as primary responders front of an event with radiological dispersive device; Principais acoes de protecao radiologica para equipe medica como primeiros respondedores frente a um evento com dispositivo de dispersao radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Duque, Hildanielle Ramos

    2015-07-01

    After the terrorist attack in New York, USA, in 2001, there was a worldwide concern about possible attacks using radioactive material in conventional detonators, called as Radiological Dispersal Device (RDD) or 'dirty bomb'. Several studies have been and are being made to form a global knowledge about this type of event. As until now, fortunately, there has not been an event with RDD, the Goiania Radiological Accident in Brazil, 1987, is used as a reference for decision-making. Several teams with technical experts should act in an event with RDD, but the medical staffs who respond quickly to the event must be properly protected from the harmful effects of radiation. Based on the radiological protection experts performance during the Goiania accident and the knowledge from lessons learned of many radiological accidents worldwide, this work presents an adaptation of the radiation protection actions for an event with RDD that helps a medical team as primary responders. The following aspects are presented: the problem of radioactive contamination from the explosion of the device in underground environment, the actions of the first responders and evaluation of health radiation effects. This work was based on specialized articles and papers about radiological accidents and RDD; as well as personal communication and academic information of the Institute of Radiation Protection and Dosimetry. The radiation protection actions, adapted to a terrorist attack event with RDD, have as a scenario a subway station in the capital. The main results are: the use of the basic radiation protection principle of time because there is no condition to take care of a patient keeping distance or using a shielding; the use of full appropriate protection cloths for contaminating materials ensuring the physical safety of professionals, and the medical team monitoring at the end of a medical procedure, checking for surface contamination. The main conclusion is that all medical actions

  5. O programa de qualidade no setor hospitalar e as atividades reais da enfermagem: o caso da medicação The quality program in the hospital sector and the nursing activities: the medication case

    Directory of Open Access Journals (Sweden)

    Rosana Maria de Aguiar Guedes

    2005-12-01

    Full Text Available O objetivo deste estudo é analisar a política de qualidade implementada pela gestão hospitalar na farmácia central e as características da atividade de medicar realizada pelo auxiliar de enfermagem (AE. Adotou-se a abordagem proposta pela escola francesa de ergonomia. Avaliou-se o funcionamento do hospital e estudou-se a atividade do trabalho do AE em tempo real, possibilitando compreender as dificuldades enfrentadas no cotidiano e as estratégias implementadas. Viu-se que a atividade de trabalho está inserida num paradoxo organizacional em que a qualidade exigida para o cumprimento da missão de medicar dificulta o cumprimento da própria tarefa, comprometendo, em última análise, a assistência ao paciente.The aim of this study is to analyze the quality policy implemented by the hospital management in the central chemistry and the characteristics of the medication activities performed by the nursing assistants (NA.The approach of the French School of Ergonomics was adopted. It was assessed the Hospital working situation and the activity performed by the nursing assistant in real time which have allowed to understand the difficulties faced by the workers and the strategies adopted to overcome them. It was observed that the working activity is part of an organizational paradox where the expected quality to fulfil the medication mission has been difficult to achieve, endangering, ultimately the assistance to the patients.

  6. Study Of Clinical Profile of Allergic Contact Dermatitis In Pune

    Directory of Open Access Journals (Sweden)

    Sayal S K

    1999-01-01

    Full Text Available One hundred and twenty five cases of clinically diagnosed allergic contact dermatitis were studied. All patients were subjected to patch test with standard test allergens and also with suspected test allergens based on history and clinical profile. Allergic contact dermatitis due to Parthenium hysterophorus was commonest and found in 64% cases, followed by wearing apparel and jewellery in 16.8%, topical medicaments in 8% and cosmetics and occupational contactants in 5.6% cases each. The common individual allergens other than parthenium, were nickel in 8.8%, leather, hair dye and cement in 3.2% each, nitrofurazone and petrol, oil, lubricant (POL in 2.4% each. Patch test with suspected allergens was positive in 72% of cases.

  7. Investigação experimental da utilidade da medicação no pós-operatório em cirurgia refrativa Experimental investigation of postoperative use of medication in refractive surgery

    Directory of Open Access Journals (Sweden)

    Sâmia Ali Wahab

    2005-04-01

    with 0.3% ciprofloxacin associated with dexamethasone and ketorolac tromethamine every 4 hours for 24 hours (group 2. The animals were sacrificed and the corneas were divided into two halves, which were sent to analyzed by the microbiology and histopathology laboratory. RESULTS: In the control group, Staphylococcus aureus could be retrieved from all corneas, while in group 2, only 50% showed positive cultures (p=0.0128. Histopathology concerning polymorphonuclear cells showed an intense degree of inflammation in group 1 (p=0.0203 and regarding monomorphonuclear cells, it was also more intense in group 1 (p=0.0051. CONCLUSION: This study suggests that the use of wide-spectrum antibiotic associated with anti-inflammatory eye drops has a significant effect on the reduction of a potential infectious and inflammatory process after refractive surgery.

  8. Clonidina como medicação pré-anestésica em facectomias: comparação entre as doses de 100 µg e 200 µg La clonidina como medicación preanestésica en facectomías: comparación entre las dosis de 100 µg y 200 µg Clonidine as pre-anesthetic medication in cataract extration: comparison between 100 µg and 200 µg

    Directory of Open Access Journals (Sweden)

    José Roquennedy Souza Cruz

    2009-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Avaliar a sedação, a pressão intraocular e as alterações hemodinâmicas com o uso de doses baixas de clonidina, 100 µg e 200 µg por via oral, como medicação pré-anestésica para operações de catarata em regime ambulatorial. MÉTODO: O trabalho foi realizado pela Universidade Federal de São Paulo, sendo um estudo clínico aleatório e duplamente encoberto em 60 pacientes, de ambos os sexos, estado físico ASA 1 e 2, com idade mínima de 18 anos e máxima de 80 anos. Os pacientes foram divididos em três grupos: placebo, clonidina 100 µg e 200 µg. As medidas de pressão intraocular, frequência cardíaca e pressão arterial, além da avaliação de sedação, foram feitas antes e após 90 minutos da administração da clonidina. Os níveis de sedação foram classificados de acordo com a escala de sedação de Ramsay. RESULTADOS: Pacientes que receberam placebo e 100 µg de clonidina não apresentaram redução da frequência cardíaca com diferença estatística significativa, enquanto os que receberam 200 µg de clonidina, sim. Os que receberam clonidina na dose de 200 µg apresentaram redução na pressão arterial sistólica e diastólica (p JUSTIFICATIVA Y OBJETIVOS: Evaluar la sedación, la presión intraocular y las alteraciones hemodinámicas con el uso de bajas dosis de clonidina, 100 µg y 200 µg por vía oral, como medicación preanestésica para operaciones de catarata en el ambulatorio. MÉTODO: El trabajo fue realizado por la Universidad Federal de São Paulo, siendo un estudio clínico aleatorio y doble ciego en 60 pacientes de los dos sexos, estado físico ASA 1 y 2, con edad mínima de 18 años y máxima de 80 años. Los pacientes fueron divididos en tres grupos: placebo, clonidina 100 µg y 200 µg. Las medidas de presión intraocular, frecuencia cardiaca y presión arterial, además de la evaluación de sedación, fueron hechas antes y después de los 90 minutos iniciales en que se

  9. El Hamster mascota. Principales motivos de consulta medica

    OpenAIRE

    Hugues B:; Torres M A:; Navaroli F

    2007-01-01

    Resumen incidencia son las relacionadas con el manejo deficiente (90%). Se enfatiza en la Se estudian las principales enfermedades, importancia que tiene el conocimiento del por la que han sido atendidos los hámsteres sistema de crianza y manejo de los mascotas en el periodo comprendido entre animales de compañía y afectivos y se 1999-2006 y se exponen sus causas. Las recomienda la instrucción y educación de afectaciones del sistema osteomuscular los propietarios de las mascota para son...

  10. Os grandes consumidores de consultas medicas: um estudo de familia

    Directory of Open Access Journals (Sweden)

    M. Pereira Graça

    2002-01-01

    Full Text Available Este artículo describe un estudio sobre algunas características familiares de sujetos grandes consumidores de servicios de salud. Por un lado, se compara un grupo de grandes consumidores de servicios de salud, a nivel de número de consultas, con un grupo control en términos de funcionamiento familiar y actitudes hacia los médicos y la Medicina; por otro lado, se estudia la relación entre la dinámica familiar y las actitudes hacia la Medicina y los médicos en el grupo de los grandes consumidores. Los resultados muestran que los dos grupos de usuarios son significativamente diferentes; además, en el grupo de grandes consumidores el funcionamiento familiar problemático parece ser un factor intermediario en el desarrollo de actitudes menos negativas hacia los médicos y la Medicina. Se discuten las implicaciones que los resultados tienen a nivel de intervención terapéutica.

  11. Thermoluminescence in medical dosimetry; Termoluminiscencia en dosimetria medica

    Energy Technology Data Exchange (ETDEWEB)

    Rivera, T., E-mail: trivera@ipn.mx [IPN, Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada, Av. Legaria 694, Col. Irrigacion, 11500 Mexico D. F. (Mexico)

    2011-10-15

    The dosimetry by thermoluminescence (Tl) is applied in the entire world for the dosimetry of ionizing radiations specially to personal and medical dosimetry. This dosimetry method has been very interesting for measures in vivo because the Tl dosimeters have the advantage of being very sensitive in a very small volume and they are also equivalent to tissue and they do not need additional accessories (for example, cable, electrometer, etc.) The main characteristics of the diverse Tl materials to be used in the radiation measures and practical applications are: the Tl curve, the share homogeneity, the signal stability after the irradiation, precision and exactitude, the response in function with the dose and the energy influence. In this work a brief summary of the advances of the radiations dosimetry is presented by means of the thermally stimulated luminescence and its application to the dosimetry in radiotherapy. (Author)

  12. El Hamster mascota. Principales motivos de consulta medica

    Directory of Open Access Journals (Sweden)

    Hugues B:

    2007-04-01

    Full Text Available Resumen incidencia son las relacionadas con el manejo deficiente (90%. Se enfatiza en la Se estudian las principales enfermedades, importancia que tiene el conocimiento del por la que han sido atendidos los hámsteres sistema de crianza y manejo de los mascotas en el periodo comprendido entre animales de compañía y afectivos y se 1999-2006 y se exponen sus causas. Las recomienda la instrucción y educación de afectaciones del sistema osteomuscular los propietarios de las mascota para son las frecuentes (41%, seguidas por las garantizar el bienestar animal. del sistema digestivo (16%, dermatológico (15% y visual (14%. Las causas de

  13. Le medicament du mois: Olmesartan medoxomil (Belsar ou Olmetec)

    OpenAIRE

    Krzesinski, Jean-Marie; Scheen, André

    2004-01-01

    Olmesartan medoxomil (Belsar, Olmetec) developed by Sankyo Pharma and proposed by Sankyo Pharma but also Menarini is a new angiotensin II ATI receptor blocker. Its indication is the treatment of hypertension. Olmesartan is indeed an antihypertensive agent with an efficacy dependent on the dose from 10 to 40 mg. It is taken once a day, because of a long duration of action. This prodrug has a dual elimination pathway (biliary and renal). The contraindications are the same as for the other sarta...

  14. MedicaI Astrology in Spain During the Seventeenth Century

    OpenAIRE

    Lanuza Navarro, Tayra

    2006-01-01

    [EN] It is well known that astrological practice during the Early Modem period was closely related to medicine, and that it provided a tool for diagnosis and treatments. An interesting aspect of this relationship of medicine and astrology is the recognition of the prevailing ideas about medical astrology in the astrological works and astrological-medical treatises. This article discusses the ideas of Galenism and the astrological doctrines that established such a strong relationship between a...

  15. Medical exposures, challenge and impacts; Exposiciones medicas, retos e impactos

    Energy Technology Data Exchange (ETDEWEB)

    Cardenas H, J.; Molina P, D.; Martinez G, A. [Centro de Proteccion e Higiene de las Radiaciones, Calle 20 No. 4113 e/41 y 47 Playa, 11300 La Habana, Direccion Postal A.P. 6195, C.P. 10600 (Cuba)

    2006-07-01

    The medical exposures have a significant contribution to the doses received by the population, reasons for what has not been considered during time its risks. In such sense in the last years the scientific community and international organizations have defined requirements for contribute to that the doses to those patients are the minimum ones necessary to achieve its diagnostic objective. The work exposes the radiological contribution, risks, uses and the actions for to improve the safety of the medical exposures. (Author)

  16. La ricerca medica nel web: modelli e stili

    OpenAIRE

    Vidale, Claudia

    2008-01-01

    The quality of patient care is strictly connected to the quality of the related services offered to health personnel by the information specialists and clinical libraries. The health professional’s information needs require a good level of competence in searching biomedical databases in order to achieve satisfactory results. The health professionals’ main concern is the care of the patient, so they have little time to dedicate to learning the complexities of the language used to search the va...

  17. Vigilância em saúde na enfermagem: o caso das medicações sem prescrição em crianças Vigilancia de la salud en enfermería: el caso de los medicamentos sin receta para los niños Surveillance at health in nursing: the case of medications without prescription in children

    Directory of Open Access Journals (Sweden)

    Renata Araújo de Medeiros

    2011-06-01

    Full Text Available A automedicação é um hábito comum em nosso país e sempre foi um assunto muito discutido e controverso. Muitas mães recorrem à prática de medicar por conta própria suas crianças quando estas apresentam algum sintoma decorrente ou não de alguma patologia. Esta pesquisa teve como objetivo descrever os motivos que levaram as mães a administrarem medicações sem prescrição profissional a seus filhos. Foram entrevistadas 20 mães de crianças menores de 10 anos cadastradas no programa de Crescimento e Desenvolvimento da Unidade de Saúde da Família do município de Passagem, interior do Rio Grande do Norte. Entre as 20 mães entrevistadas, 30% automedicaram seus filhos com antipirético, 50% automedicaram devido à febre, 43% foram motivadas pela experiência anterior e 90% não relataram efeitos adversos. A automedicação na população infantil reforça a necessidade de um melhor esclarecimento às mães sobre os riscos da automedicação.La automedicación es una conducta frecuente en nuestro país y siempre ha sido un tema muy cuestionable y polémico. Muchas madres recuren a la práctica de auto-medicar sus niños cuando ellos presentan cualquier síntoma resultante o no de una patología. Esta encuesta objetiva describir los motivos que llevaron las madres a utilizar medicamentos sin prescripción profesional en sus hijos. Se entrevistaron 20 madres de niños menores que diez años registradas en el Programa de Crecimiento y Desarrollo de la Unidad de Salud de la Familia en la ciudad de Passagem, en el estado de Rio Grande do Norte, en Brasil. Entre las 20 madres encuestadas, 30% auto-medicaron a sus hijos con Antipirético, 50% los auto-medicaron debido a la observación de fiebre, 43% lo hicieron basadas en experiencias previas y 90% no han relatado efectos adversos. La automedicación entre la población de niños demuestra la necesidad de que mejor se informe a las madres cerca de los peligros de la auto-medicación.The self

  18. Ocorrências iatrogênicas com medicação em Unidade de Terapia Intensiva: condutas adotadas e sentimentos expressos pelos enfermeiros Ocurrencias iatrogénicas com medicamentos en Unidad de Cuidados Intensivos: conductas y sentimientos de los enfermeros Iatrogenic occurrences with medication in I. C.U: nurse's procedures and feelings

    Directory of Open Access Journals (Sweden)

    Katia Grillo Padilha

    2002-03-01

    Full Text Available Ocorrências iatrogênicas com medicação na UTI são eventos indesejáveis que exigem pronta intervenção do enfermeiro. Opresente estudo foi realizado com os seguintes objetivos:- verificar a conduta dos enfermeiros diante de uma ocorrência commedicação, identificar os sentimentos vividos nessas situações e caracterizar os fatores relacionados a esses eventos. Pormeio de um questionário respondido por 148 enfermeiros de UTI (76,7% de 7 hospitais do Município de São Paulo, nosanos de 1997 e 1998, os dados foram obtidos e analisados segundo freqüência absoluta e percentual. Os resultados permitiramconcluir que as condutas mais citadas incluíram: comunicar o fato ao médico (31,7%, intensificar os controles (26,5% ecomunicar a chefia de enfermagem (13,5%. Ansiedade, impotência e culpa foram sentimentos mais apontados com38,1%, 14,6% e 12,3%, respectivamente. O fator relacionado às ocorrências mais freqüente foi a displicência do funcionário(23,1%. Quanto à vivência desse tipo de ocorrência, a maior porcentagem (43,2% referiu ter vivido situação semelhanteraras vezes.Ocurrencias iatrogénicas com medicamentos en UCI no son hechos esperados y necesitan rápida actuación de los enfermeros.El estudio tuvo los siguientes objectivos: verificar la conducta de los enfermeros delante de una ocurrencia iatrogénica commedicamnetos; identificar los sentimientos provocados por tales situaciones y identificar los factores vinculados a talesocurrencias. Ciento cuarenta ocho enfermeros (76,7% de 7 UCI de la ciudad de São Paulo, Brasil, contestaran una encuestaen los años de 1997 y 1998. Los resultados llevan a concluir que las conductas más frecuentes incluyeran: comunicar elhecho al médico (31,7%, aumentar los controles (26,5% y comunicar el hecho al director de enfermería (13,5%. Ansiedad(38,1%, impotencia (14,6% y culpa (12,3%fueranlos sentimientos más frecuentes. El factor más importante relacionado a las ocurrencias iatrg

  19. Karyological studies in ten species of Citrus (Linnaeus, 1753 (Rutaceae of North-East India

    Directory of Open Access Journals (Sweden)

    Marlykynti Hynniewta

    2011-11-01

    Full Text Available Ten Citrus (Linnaeus, 1753 species of North-East India have been karyo-morphologically analysed. All studied species had 2n=18 chromosomes without any evidence of numerical variation. All the chromosomes were found to be of metacentric and sub-metacentric in all the species; the morphology of the chromosomes showing size difference only. Symmetrical karyotype which does not have much difference in the ratio of longest to shortest chromosome in all the species was observed. Three species, C. grandis (Osbeck, 1757, C. reticulata (Blanco, 1837 and C. medica (Linnaeus, 1753 are identified as true basic species from asymmetry studies of karyotypes as they reflect on the primitive nature of their genomes. C. indica (Tanaka, 1937 occupies a special taxonomic position within the genus Citrus as a progenitor for other cultivated species

  20. Ocorrência e identificação de espiroquetas intestinais em suínos em granjas de porte industrial de duas regiões criatórias do Estado do Rio Grande do Sul, em relação à medicação da ração Ocurrence and identification of swine intestinal spirochetes in industrial pig herds from two raising areas in the State of Rio Grande do Ssul, Brazil, in relation to feed medication

    Directory of Open Access Journals (Sweden)

    David Emilio Barcellos

    2003-08-01

    Full Text Available As infecções intestinais por espiroquetas em suínos, na fase que se segue ao alojamento nos prédios de recria, são predispostas por fatores como o estresse da movimentação, mistura entre animais imunes e excretores com leitões não imunes, deficiências nas condições ambientais e troca no tipo da ração usada. Para contrabalançar esses efeitos, é uma prática rotineira a inclusão de antimicrobianos à ração, em doses de promoção de crescimento ou de controle. O presente trabalho avaliou a ocorrência da infecção por Brachyspira spp. em rebanhos suínos do Estado do Rio Grande do Sul, tentando relacionar com o tipo de programa de uso de antimicrobianos adotado. Foram examinados 393 suabes retais colhidos de 38 granjas do RS (22 usando rações medicadas e 16 com ração sem medicação. A B. hyodysenteriae e B. pilosicoli foram detectadas respectivamente em 0% e 6,25% das granjas medicadas e de 31,8% e 45,5% das granjas não medicadas. Entre os suabes examinados, a B. hyodysenteriae e B. pilosicoli estavam presentes respectivamente em 0 e 0,6% dos materiais colhidos de granjas medicadas e de 3,9% e 7,3% em granjas não medicadas. O presente trabalho suporta a opinião de diversos autores que sugeriram a influência direta da inclusão de antimicrobianos à ração em doses de promoção de crescimento ou em dose de controle e a ocorrência de diarréias espiroquetais em leitões. Entretanto, pelas características multifatoriais desse tipo de patologia, seriam necessários estudos adicionais abrangendo um número maior de variáveis entre aquelas possivelmente envolvidas no desencadeamento das diarréias, antes que fosse obtida uma conclusão definitiva.Intestinal spirochaetal infections in pigs following transportation to growing facilities is predisposed by stressful factors such as contact between carriers and non-immune piglets, defficient environment and diet changes. To neutralize such effects, it is a common practice to

  1. Uniformity studies inter cut with continuous movement PET stretcher; Homogeneidad intercorte de estudios PET con movimiento continuo de camila

    Energy Technology Data Exchange (ETDEWEB)

    Cons Perez, N.; Gomez Gonzalez, N.; Garcia Repiso, S.; Hernandez Rodriguez, J.; Montes Fuentes, C.; Garcia Ledesma, J.; Diez Gallego, M. A.

    2015-07-01

    One of the latest advances in PET scanners is the introduction of acquisitions with continuous movement of stretcher (CBM) Among the benefits that this technology brings they are: lower axial variation of noise, greater flexibility in planning studies with different levels of statistics for different anatomical and greater patient comfort regions. Behavior unexpected because the concentration obtained in all CBMs studies with PET-CT scanner Biograph mCTFlow (Slemens Medica Solutions) we propose a quantitative analysis with a series of parameters chosen to assess the inhomogeneity between cuts in the concentration obtained by homogeneous mannequins. A comparison with studies of static bed (S and S) indicates a problem only mode dynamic bed. (Author)

  2. Effects of Chinese Materia Medica of Qi Benefiting, Yin Nourishing, Stasis Removing, and Collaterals Dredging and Their Dissembled Recipes on Nephrin of Diabetes Mellitus Model Rats%益气养阴化瘀通络中药及其拆方对糖尿病大鼠模型nephrin蛋白的影响

    Institute of Scientific and Technical Information of China (English)

    李黎莉; 陈志强; 王月华; 张江华; 尹智炜; 李林林; 张雪云; 王凤丽

    2012-01-01

    Objective To observe the effects of Chinese materia medica (CMM) of qi benefiting, yin nourishing, stasis removing, and collaterals dredging (QBYNSRCD) and their dissembled recipes on nephrin of diabetes mellitus (DM) model rats. Methods The DM model was induced by high fat diet combined with low dose STZ. Rats in the normal control group (abbreviated as Group N) and the model group (abbreviated as Group M) were administered with ultrapure water at corresponding volume by gastrogavage. Rats in the CMM of QBYNSRCD treatment group (abbreviated as Group YHT) were administered with CMM of QBYNSRCD, composed of milkvetch root, rehmannia root, danshen root, chuanxiong (2 packages each), solomonseal, earth worm, leech, and scorpion (1 package each), which was administered at 1. 0 g/kg. Rats in the CMM of qi benefiting, yin nourishing, and stasis removing (QBYNSR) treatment group (abbreviated as Group YT) were administered with CMM of QBYNSR, composed of milkvetch root, rehmannia root, danshen root, chuanxiong (2packages each), and solomonseal (1 package each), which was administered at 0. 92 g/kg. Rats in the CMM of qi benefiting, yin nourishing, and collaterals dredging (QBYNCD) treatment group (abbreviated as Group YT) were administered with CMM of QBYNCD, composed of milkvetch root, rehmannia root (2 packages each), solomonseal, earth worm, leech, and scorpion (1 package each), which was administered at 0. 79 g/kg. The volume was set to 1 mL/100 g, once daily by gastrogavage, for total 32 weeks. Rats' body weight was measured. By the end of medication, urinary creatinine (UCr), 24-h urinary albumin (U-alb), and urinary nephrin (U-neph-rin), fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), serum creatinine (SCr), and nephrin of kidney tissues homogenate (K-nephrin) were detected. The renal tissue sections were stained with Masson. The pathomorphological changes were observed. Results The body weight of rats in Group N increased gradually. After modeling

  3. Synergistic Manipulation of Intercrop Combining Biological Medicaments on the Population Dynamics of Psylla Chinensis and Predators in Pear Orchard%梨园作物间作与生物药剂对梨木虱及其捕食性天敌种群数量动态的协同调控作用

    Institute of Scientific and Technical Information of China (English)

    何凯; 高晓阳; 赵印勇; 张建设; 花日茂; 巫厚长

    2015-01-01

    resistance to any kinds of pesticides. This research is to estimate quantitatively the effect of intercrop combining with biological medicament controlling the Psylla chinensis ecologically. In 2013 and 2014, the manipulating experiment was established in pear orchard. The synergistic manipulation of pear intercropping Trifolium repens and Platycodon grandiflorum combining with the biological agent on the population dynamics of P. chinensis and their predators were determined systematically. The results showed that the total population size of predators in the areas of intercropping T. repens and P. grandiflorum were higher than that in the bare area by artificial weeding. In 2013, the predator of dominant species was O. minutes in the area of intercropping T. repens and P. fuscipes was in the area of intercropping P. grandi-florum. In 2014, E. graminicolum and T. chinensis dominated in the area of intercropping T. repens;H. axyridis, P. japonica, E. balteata and E. graminicolum dominated in the area of intercropping P. grandiflorum. In 2013, the nymphae populations of P. chinensi in the areas of both intercropping T. repens and P. grandiflorum combining with the biological agent on June 18 were significantly higher and on other dates were not significant difference compared with the bare area with conventional pesticide application. In 2014, the population densities of both adults and nymphae of P. chinensis were significantly lower in the areas of both intercropping T. repens and P. grandiflorum combining with the bio-logical agent than that in the bare area with conventional pesticide application during all the period of P. chinensis occurence. This research demonstrated that the measure of intercropping perennial T. repens and P. grandiflorum in pear orchard one year later combining with appli-cation of the biological agent SOVONA could substitute half amount of chemical pesticide usage. The synergistic manipulation effect of this measure was significantly higher

  4. [Study on characteristics of pharmacological effects of traditional Chinese medicines distributing along stomach meridian based on medicinal property combination].

    Science.gov (United States)

    Zhang, Bai-Xia; Gu, Hao; Guo, Hong-Ling; Ma, Li; Wang, Yun; Qiao, Yan-Jiang

    2014-07-01

    At present, studies on traditional Chinese medicine (TCM) properties are mostly restricted to a single or two kinds of medicinal properties, but deviated from the holism of the theoretical system of TCMs. In this paper, the characteristics of pharmacological effects of different property combinations of TCMs distributing in the stomach meridian were take as the study objective. The data of properties of TCMs distributing in the stomach meridian was collected from the Pharmacopoeia of the People's Republic of China (2005). The data of pharmacological effects of TCMs distributing in the stomach meridian was collected from all of literatures recorded in Chinese Journal Full-text Database (CNKI) since 1980, Science of Chinese Materia Medica (Yan Zhenghua, People's Medical Publishing House, 2006) and Clinical Science of Chinese Materia Medica (Gao Xuemin, Zhong Gansheng, Hebei Science and Technology Publishing House, 2005). The corresponding pharmacological effects of property combinations of TCMs distributing in the stomach meridian was mined by the method of association rules. The results of the association rules were consistent with the empirical knowledge, and showed that different medicinal property combinations had respective pharmacological characteristics, including differences and similarities in pharmacological effects of different medicinal property combinations. Medicinal property combinations with identical four properties or five tastes showed similar pharmacological effects; whereas medicinal property combinations with different four properties or five tastes showed differentiated pharmacological effects. However, medicinal property combinations with different four properties or five tastes could also show similar pharmacological effects. In this study, the medicinal property theory and the pharmacological effects of TCMs were combined to reveal the main characteristics and regularity of pharmacological effects of TCMs distributing in the stomach meridian

  5. Comparative use of InDel and SSR markers in deciphering the interspecific structure of cultivated citrus genetic diversity: a perspective for genetic association studies.

    Science.gov (United States)

    García-Lor, Andrés; Luro, François; Navarro, Luis; Ollitrault, Patrick

    2012-01-01

    Genetic stratification associated with domestication history is a key parameter for estimating the pertinence of genetic association study within a gene pool. Previous molecular and phenotypic studies have shown that most of the diversity of cultivated citrus results from recombination between three main species: C. medica (citron), C. reticulata (mandarin) and C. maxima (pummelo). However, the precise contribution of each of these basic species to the genomes of secondary cultivated species, such as C. sinensis (sweet orange), C. limon (lemon), C. aurantium (sour orange), C. paradisi (grapefruit) and recent hybrids is unknown. Our study focused on: (1) the development of insertion-deletion (InDel) markers and their comparison with SSR markers for use in genetic diversity and phylogenetic studies; (2) the analysis of the contributions of basic taxa to the genomes of secondary species and modern cultivars and (3) the description of the organisation of the Citrus gene pool, to evaluate how genetic association studies should be done at the cultivated Citrus gene pool level. InDel markers appear to be better phylogenetic markers for tracing the contributions of the three ancestral species, whereas SSR markers are more useful for intraspecific diversity analysis. Most of the genetic organisation of the Citrus gene pool is related to the differentiation between C. reticulata, C. maxima and C. medica. High and generalised LD was observed, probably due to the initial differentiation between the basic species and a limited number of interspecific recombinations. This structure precludes association genetic studies at the genus level without developing additional recombinant populations from interspecific hybrids. Association genetic studies should also be affordable at intraspecific level in a less structured pool such as C. reticulata. PMID:22160318

  6. The Effect of Calcium Hydroxide on the Bond Strength of Resilon/Epiphany Self-Etch and Assessment of Calcium Hydroxide Removal Techniques: An Ex-Vivo Study

    Directory of Open Access Journals (Sweden)

    B. Bolhari

    2012-01-01

    Full Text Available Objective: Calcium hydroxide is the most widely used intracanal medicament in endodontics, which should be removed prior to permanent root canal filling to minimize its intervention with the bonding of endodontic sealers. This ex-vivo study aimed to evaluate the effect of pretreatment with calcium hydroxide on the bond strength of Resilon/Epiphany self etch (SE to the radicular dentin after removing the calcium hydroxide by hand file or ultrasonic methods.Materials and Methods: Thirty-six single-rooted human extracted teeth were used in this study. After root canal preparation, the teeth were divided into three groups. In group 1, as the control, no pretreatment was performed; while in groups 2 and 3, this was carried out using calcium hydroxide paste. After one week, the paste was removed with hand stainless steel K-files in group 2 and ultrasonic instrumentation in group 3. All samples were obturated with Resilon/Epiphany SE. One-millimeter slices of mid-root dentin were prepared for the push-out test (14 slices per group. After the bond strength was assessed, the failure modes were examined. The data were analyzed using one-way ANOVA and Dunnett Post Hoc tests.Results: Group 2 significantly showed the lowest bond strength (0.947 ± 0.47 (P = 0.01. No significant differences were found between the control group (2.32 ± 1.43 and group 3 (1.78 ± 1.04 (P = 0.01.Conclusions: Under the conditions of this ex vivo study, calcium hydroxide as the intracanal medicament and its removal using hand instrumentation adversely affected the bond strength of Resilon/Epiphany SE.

  7. Differential Mechanisms of Ang (1-7)-Mediated Vasodepressor Effect in Adult and Aged Candesartan-Treated Rats

    OpenAIRE

    Jones, E S; K. M. Denton; Widdop, R. E.; Bosnyak, S.

    2012-01-01

    Angiotensin (1-7) (Ang (1-7)) causes vasodilator effects in Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs) via angiotensin type 2 receptors (AT2R). However, the role of vascular AT2R in aging is not known. Therefore, we examined the effect of aging on Ang (1-7)-mediated vasodepressor effects and vascular angiotensin receptor localization in aging. Blood pressure was measured in conscious adult (~17 weeks) and aged (~19 months) normotensive rats that received drug combinati...

  8. Prevalence of Enterococcus faecalis and Porphyromonas gingivalis in infected root canals and their susceptibility to endodontic treatment procedures: A molecular study

    Directory of Open Access Journals (Sweden)

    Stojanović Nikola

    2014-01-01

    Full Text Available Introduction. Because apical periodontitis is recognizably an infectious disease, elimination or reduction of intracanal bacteria is of utmost importance for optimum treatment outcome. Objective. The prevalence of Enterococcus faecalis and Porphyromonas gingivalis in infected root canals was studied Also, the effect of endodontic therapy by using intracanal medicaments, calcium hydroxide paste (CH or gutta-percha points containing calcium hydroxide (CH-GP or chlorhexidine (CHX-GP on these microorganisms was assessed by polymerase chain reaction (PCR assay. Methods. Fifty-one patients with chronic apical periodontitis were randomly allocated in one of the following groups according to the intracanal medicament used: CH, CH-GP and CHX-GP group. Bacterial samples were taken upon access (S1, after chemomechanical instrumentation (S2 and after 15-day medication (S3. PCR assay was used to detect the presence of selected bacteria. Results. E. faecalis was detected in 49% (25/51 and P. gingivalis in 17.6% (9/51 of the samples. Samples which showed no bacterial presence at S1 were excluded from further analysis. Overall analysis of all 29 samples revealed significant differences between S1 and S2 (p<0.001, S2 and S3 (p<0.05, and S1 and S3 (p<0.001. When distinction was made between the intracanal medications, there was a significant difference in the number of PCR positive samples between S1 and S2, S1 and S3, but not between S2 and S3 samples. Conclusion. E. faecalis is more prevalent than P. gingivalis in primary endodontic infection. Intracanal medication in conduction with instrumentation and irrigation efficiently eliminates E. faecalis and P. gingivalis from infected root canals.

  9. [Vibration-assisted music therapy reduces pain and promotes relaxation of para- and tetraplegic patients. A pilot study of psychiatric and physical effects of simultaneous acoustic and somatosensory music stimulation as pain management].

    Science.gov (United States)

    Mariauzouls, C; Michel, D; Schiftan, Y

    1999-11-01

    Pain is a well known phenomenon in posttraumatic spinal cord injuries. Nearly 10% of the patients develop most severe, invalidizing, as a rule neurogenic pain conditions that are hardly accessible to conventional therapies. A pilot study was therefore conducted with 10 paraplegics and tetraplegics suffering chronic pain, investigating how vibration supported music therapy with the Musica Medica method affected pain experience, tension/relaxation and well-being. In addition to subjective experience, we measured physiological parameters (finger tip skin temperature, electrodermal activity, heart rate, respiration frequency) during the therapy sessions. All patients had a high acceptance of the method which throughout the group had brought about an increase in relaxation and well-being as well as a decrease of pain experience. The autonomic nervous system variables correlated with relaxation and in addition pointed to an activating impact of the therapy chosen.

  10. Study on biological and environmental factors for azoospermia

    Directory of Open Access Journals (Sweden)

    Spas Dzhoglov

    2016-09-01

    Full Text Available The absence of sperm in the seminal fluid is known as azoospermia. This medical condition is in a direct association with male's infertility. A complete medical history, physical examination, tests of selected hormones and tests for male fertility (including sperm analysis are used for the diagnosis of azoospermia. The number of 1314 men, with fertility problems, at age between 20 and 67 years, were included in this investigation. The data obtained in the study showed that azoospermia occurred in 5.25% of the group studied. The Klinefelter syndrome was cytogenetically diagnosed in 2.9% of the male individuals. There was found that 44.3% of males with azoospermia have been smokers, 7.1% of them – addicted to drugs, 17.1% have taken different medicaments, 4.35% – have had radiation therapy, 4.35% have had a diagnosis "varicocele". The volume of the ejaculate was less than 2 ml in 37.68% of the men and more than 7 ml in 2.89% of them.

  11. The influence of the stomatognathic system on explosive strength: a pilot study.

    Science.gov (United States)

    Patti, Antonino; Bianco, Antonino; Messina, Giuseppe; Paoli, Antonio; Bellafiore, Marianna; Battaglia, Giuseppe; Iovane, Angelo; Traina, Marcello; Palma, Antonio

    2016-01-01

    [Purpose] Recent findings suggest there is an interesting interaction between the stomatognathic system and the musculoskeletal system. The aim of this study was therefore to examine the influence of the temporomandibular joint on the explosive strength of the lower limbs. [Subjects and Methods] An observational study was carried out. The subjects were 60 male football players who voluntarily participated in the investigation. After a warm-up phase of 10 minutes, each participant performed three Squat Jumps (SJ) with different mandible positions: mouth closed and mouth open. SJ heights were recorded using a Sensor Medica force platform and the FreeMed system. [Results] Sixty participants were enrolled in this study (age: 24 ± 7 yrs; height: 174 ± 4.6 cm; weight 63.7 ± 7.6 kg). The SJ heights with the mouth closed, 38.50 ± 4.0 cm, were shorter than those with the mouth open, 40.4 ± 4.1 cm. Statistical analysis showed there was a statistically significant difference between the performances. [Conclusion] This pilot study highlighted that occlusal factors can influence physical performance and this could have practical applications in sports and exercise science. However, our results have to be confirmed in studies with larger numbers of participants and supported by other investigations. PMID:26957731

  12. A comparative evaluation of endodontic practice trends in India: "The Mumbai study"

    Directory of Open Access Journals (Sweden)

    Anil Kohli

    2014-01-01

    Full Text Available Introduction: Multiple treatment protocols are available to the Indian endodontist. Hence a survey is required to recognize the common trends in endodontics and set a basic standard of treatment. Aims and Objectives: The aim of this article is to present practice trends among Indian endodontists and compare the same with established practice trends internationally through various surveys that have been conducted respectively. Materials and Methods: Questionnaires were mailed to 1085 endodontists in dental schools and private practice in India. A response rate of 42% was observed. The data was analyzed and compared with other studies. Results: Most of the endodontists in India follow the basic protocols and techniques in their practices. 40% of the Endodontists preferred digital radiography technique. 2.5% NaOCl is the most preferred irrigant of choice for primary root canal treatment and 2% chlorhexidine in retreatment cases. Calcium hydroxide was the most preferred intracanal medicament in all clinical situations. Lateral compaction (70.8% was the most widely used method. AH Plus was the most preferred root canal sealer (46.6%. Conclusion: Indian endodontists are following the basic protocol but when compared to other studies there were concepts like, the use of rubber dam and microscope which need to be improved and raised to a level that ensures international standards in clinical practice.

  13. In silico study on the effects of matrix structure in controlled drug release

    Science.gov (United States)

    Villalobos, Rafael; Cordero, Salomón; Maria Vidales, Ana; Domínguez, Armando

    2006-07-01

    Purpose: To study the effects of drug concentration and spatial distribution of the medicament, in porous solid dosage forms, on the kinetics and total yield of drug release. Methods: Cubic networks are used as models of drug release systems. They were constructed by means of the dual site-bond model framework, which allows a substrate to have adequate geometrical and topological distribution of its pore elements. Drug particles can move inside the networks by following a random walk model with excluded volume interactions between the particles. The drug release time evolution for different drug concentration and different initial drug spatial distribution has been monitored. Results: The numerical results show that in all the studied cases, drug release presents an anomalous behavior, and the consequences of the matrix structural properties, i.e., drug spatial distribution and drug concentration, on the drug release profile have been quantified. Conclusions: The Weibull function provides a simple connection between the model parameters and the microstructure of the drug release device. A critical modeling of drug release from matrix-type delivery systems is important in order to understand the transport mechanisms that are implicated, and to predict the effect of the device design parameters on the release rate.

  14. Bioactivity Studies of β-Lactam Derived Polycyclic Fused Pyrroli-Dine/Pyrrolizidine Derivatives in Dentistry: In Vitro, In Vivo and In Silico Studies.

    Directory of Open Access Journals (Sweden)

    Gowri Meiyazhagan

    Full Text Available The antibacterial activity of β-lactam derived polycyclic fused pyrrolidine/pyrrolizidine derivatives synthesized by 1, 3-dipolar cycloaddition reaction was evaluated against microbes involved in dental infection. Fifteen compounds were screened; among them compound 3 showed efficient antibacterial activity in an ex vivo dentinal tubule model and in vivo mice infectious model. In silico docking studies showed greater affinity to penicillin binding protein. Cell damage was observed under Scanning Electron Microscopy (SEM which was further proved by Confocal Laser Scanning Microscope (CLSM and quantified using Flow Cytometry by PI up-take. Compound 3 treated E. faecalis showed ROS generation and loss of membrane integrity was quantified by flow cytometry. Compound 3 was also found to be active against resistant E. faecalis strains isolated from failed root canal treatment cases. Further, compound 3 was found to be hemocompatible, not cytotoxic to normal mammalian NIH 3T3 cells and non mutagenic. It was concluded that β-lactam compound 3 exhibited promising antibacterial activity against E. faecalis involved in root canal infections and the mechanism of action was deciphered. The results of this research can be further implicated in the development of potent antibacterial medicaments with applications in dentistry.

  15. In vivo effects of a chronic contamination by uranium or cesium 137 on the pharmaceutical metabolism, of the vitamin D and cholesterol; Effets in vivo d'une contamination chronique par l'uranium ou le cesium 137 sur le metabolisme du medicament, de la vitamine D et du cholesterol

    Energy Technology Data Exchange (ETDEWEB)

    Souidi, M

    2006-11-15

    In conclusion, an animal model, miming the chronic contamination of the populations exposed to the uranium, was used for the first time to show that the chronic ingestion of a weak dose of depleted uranium can affect the level of active vitamin D without modifying the mineral homeostasis. This study shows that this radionuclide can lead molecular modifications of the CYPs and the nuclear receivers involved in the metabolism of the vitamin D not only at the level of the liver and kidney but also at the level of the independent metabolism in the brain. The deficiency in vitamin D can provoke osseous diseases such as the rickets at the child and the osteomalacia at the adult. The three categories of population the most exposed to this deficiency are the infants, the pregnant women and the old persons. Strong prevalence of the vitamin D deficiency associated with a chronic exposure to uranium could lead to osseous disorders. To verify this hypothesis, it will be necessary secondly to realize this study on individuals animal models predisposed to the rickets or to the osteomalacia. (N.C.)

  16. Comparative Effects of Angiotensin Receptor BlockadeandACE Inhibition on the Fibrinolytic and Inflammatory Responses to Cardiopulmonary Bypass

    OpenAIRE

    Billings, Frederic T.; Balaguer, Jorge M.; Yu, Chang; Wright, Patricia; Petracek, Michael R.; Byrne, John G; Brown, Nancy J.; Pretorius, Mias

    2012-01-01

    The effects of angiotensin-converting enzyme (ACE) inhibition and angiotensin II type 1 receptor blockade (ARB) on fibrinolysis and inflammation following cardiopulmonary bypass (CPB) are uncertain. This study tested the hypothesis that ACE inhibition enhances fibrinolysis and inflammation to greater extent than ARB in patients undergoing CPB.One week to five days prior to surgery, patients were randomized to ramipril 5mg/day,candesartan 16mg/day or placebo.ACE inhibition increased intraopera...

  17. Chemical Investigation and Hypotensive Activity study on some Myanmar Indigenous Medicinal Plants used in the Treatement of Hypertension

    International Nuclear Information System (INIS)

    Study of Myanmar indigenous medicinal plants used in the treatment of hypertension was conducted. The samples studied were Gant-ka-lar (Gisekia pharnaceoides), Dant-da-lun (Moringa oleifera), Egayit (Millingtonia hortensis), Sue-pan (Carthamus tinctarius), Kauk-yoe-nwe (Oxystelma esculentum), Shauk (Citrus medica) Kyet-lei-san (Vitex glabrata), and Sin-ngo-myet (Eleusine indica). In all these samples, determination of potassium had been conducted through its natural K activity by high purity germanium gamma counter and by NaI (Tl) selective channel and 'Aloka' gross gamma scintillation counters. Quantitative determination of the two elements (Na, K) and nine elements (Mg, Ca, Cr, Fe, Cu, Zn, As, Cd, Pb) in these samples were carried out by flame photometry and atomic absorption spectrophotometry (AAS), respectively. In addition, elemental analysis for these samples was conducted by using energy dispersive X-ray fluorescence (EDXRF) spectrometry. Moreover, organic compounds present in water extracts of Gant-ka-lar and Dant-da-lun were studied by phytochemical investigation. The hypotensive activities of different water extracts of Gant-ka-lar and Dant-da-lun were studied by using tail cuff method employing ''Wistar-kyoto'' rats. It was found that gant-Ka-Lar to be most effective in the treatment of hypertension

  18. Disfunção pré-frontoparietal durante o processamento de informação visuoauditiva em pacientes idosos com esquizofrenia crônica e efeitos da medicação Parieto-prefrontal dysfunction during visuo-auditory information processing in elderly, chronic schizophrenic patients and medication effects

    Directory of Open Access Journals (Sweden)

    Andrea Schmitt

    2009-01-01

    during acoustic and visual stimulation. The aim of this study was to investigate the prefronto-parietal network in elderly schizophrenia patients using the same paradigm. Additionally, we hypothesized favourable effects on brain activation by the atypical antipsychotic clozapine compared to typical neuroleptics. METHODS: We investigated 18 elderly, chronic schizophrenia patients and 21 elderly healthy controls. Nine schizophrenia patients had been medicated with clozapine and 9 had been receiving typical neuroleptics over decades. In addition to assessments with psychopathological and neuropsychological rating scales we used an acoustic and visual stimulation paradigm in a 1.5 Tesla MRI scanner to investigate BOLD-response in different brain areas. RESULTS: Compared to healthy controls schizophrenia patients showed decreased brain activation in the prefrontal and parietal cortex as well as medial anterior cingulate gyrus compared to healthy controls. In these regions, patients medicated with clozapine showed increased BOLD-response compared to patients treated with typical neuroleptics. DISCUSSION: Our study confirmed prefronto-parietal network disturbances in elderly schizophrenia patients thus pointing to the preservation of brain activation deficits and the influence of neurodevelopmental disturbances in chronic schizophrenia until old-age. CONCLUSION: The atypical antipsychotic clozapine seems to facilitate brain activation even in elderly, chronic schizophrenia patients.

  19. Study of invasion and colonization of E. faecalis in microtubes by a novel device.

    Science.gov (United States)

    Sun, Xiaoqiang; Wang, Shujing; Yang, Yue; Luo, Chunxiong; Hou, Benxiang

    2016-10-01

    Enterococcus faecalis (E. faecalis) is a species that has frequently been isolated from root canal of patients suffering from persistent periodontitis. To a great degree, the resistance of E. faecalis to irrigating solutions and intracanal medicaments is due to its invasion into the dentinal tubules. In this study, we developed a device to observe the dynamic process of the bacterial invasion into microtubes. According to the diameter of the dentinal tubules and other microstructures in the root canals, we designed four different size microtubes with different lengths in this device. As expected, E. faecalis is able to steadily grow in this device and penetrate into the microtubes, and a continuous observation is achieved. We found that the depth and speed of bacterial penetration, the extent of colonization and the arrangement of the bacteria in the microtubes are strongly influenced by the size of the microtube. The length of the microtube also influences the speed and depth of the bacterial invasion. Bacteria in microtubes with a similar diameter to the real dentinal tubules showed a discontinuous distribution, which is consistent with the final bacterial distribution in the native dentinal tubules. Considering the device's advantages such as its ability to provide real-time observations, its ability to be modified as necessary, and its standardized operation, it has great potential to be widely used as a platform for the observation of the interaction of different bacteria during an invasion course and to test the efficacy of new antibacterial agents in dentistry. PMID:27540728

  20. COMPARATIVE STUDY ON THE SUBSTITUTES USED IN AYURVEDA WITH SPECIAL REFERENCE TO SUBSTITUTES FOR PUSHKARAMULA (INULA RACEMOSA HOOK.F. VIZ., KUSHTA (SAUSSUREA LAPPA DECNE. AND ERANDAMULA (RICINUS COMMUNIS L.: A CLINICAL STUDY

    Directory of Open Access Journals (Sweden)

    J. L. N. Sastry

    2013-06-01

    Full Text Available Ayurvedic literature introduced several substitutes for the herbs which are either not available or which are not accessible for various reasons. On review of more than 35 texts and their commentaries it is found that there are more than 350 substitutes in the Ayurvedic texts from ancient to modern times. Kustha is known to therapeutics since Vedic period (2000 BC. Puskaramula and Erandamula were introduced to Ayurvedic Materia Medica by Agnivesa (500 BC. While mentioning the substitutes of Pushkaramula, Yogaratnakara quoted Kushta and Erandamula as the substitutes. Earlier author studied the pharmacognostical similarities between the three plants. Therefore, in the present study it iss decided to conduct a comparative study using the root powders of these three herbs in subjects (n=90 suffering with Tamaka Swasa (Bronchial Asthma divided into three groups. The results are suggestive that all the trial herbs have comparable therapeutic benefits in the subjects of Tamaka Swasa. While Kustha and Puskaramula have chemical as well as therapeutic similarity, Erandamula and pushkaramula shared only therapeutic similarity though chemically dissimilar. Thiss paper emphasizes the need for the identification of cost effective substitutes basing on the text in place of endangered or extinct medicinal plants.

  1. [Pharmacological primary prevention of myocardial infarction, stroke and death: A possible task?].

    Science.gov (United States)

    Keller, Christian; Müller-Ehmsen, Jochen

    2016-09-01

    The HOPE-3-Trial investigated the effect of primary prevention on cardio- and neurovascular events in patients without known atherosclerotic disease, but with intermediate risk. In a factorial design Rosuvastatin 10 mg, Candesartan 16 mg/HCT 12.5 mg or both were compared with placebo. Rosuvastatin effectively lowered LDL-cholesterol and the rate of cardio- and neurovascular complications with a NNT of approximately 500/year without detectable effect on mortalitiy. Candesartan 16 mg/HCT 12.5 mg did not influence any endpoint, however, the predefined subgroup of patients with hypertension level I had a benefit. Patients with systolic pressure effects. The benefit was solely the result of statin therapy alone. Primary prevention with Rosuvastatin can be recommended if the cardio- and neurovascular risk is 1-2%/year, independent of the initial LDL, although the NNT of 500-1400/year is high and mortalitiy is not decreased. Possibly there will be future studies with longer term follow up to verify a reduction in mortality. Therapy with Candesartan 16 mg/HCT 12,5 mg has a beneficial effect only in patients with hypertension. Further studies with different antihypertensives and more intensive blood pressure lowering are desirable. The approach of combining all three drugs within a poly-pill for primary prevention in an intermediate risk population without elevated blood pressure is not recommended. PMID:27598921

  2. Radiation protection in medical and biomedical research; Proteccion radiologica en la investigacion medica y biomedica

    Energy Technology Data Exchange (ETDEWEB)

    Fuente Puch, A.E. de la, E-mail: andres@orasen.co.cuES [Centro Nacional de Seguridad Nuclear, La Habana (Cuba)

    2013-11-01

    The human exposure to ionizing radiation in the context of medical and biomedical research raises specific ethical challenges whose resolution approaches should be based on scientific, legal and procedural matters. Joint Resolution MINSAP CITMA-Regulation 'Basic Standards of Radiation Safety' of 30 November 2001 (hereafter NBS) provides for the first time in Cuba legislation specifically designed to protect patients and healthy people who participate in research programs medical and biomedical and exposed to radiation. The objective of this paper is to demonstrate the need to develop specific requirements for radiation protection in medical and biomedical research, as well as to identify all the institutions involved in this in order to establish the necessary cooperation to ensure the protection of persons participating in the investigation.

  3. Ethnic Differences And Motivation Based On Maslow’s Theory At a MedicaL University

    OpenAIRE

    Jagmohni Kaur Sidhu

    2007-01-01

    Introduction: Motivation in Malaysia is to a largeextent influenced by the value system amongst allMalaysians. Being able to motivate employees is one ofthe important keys to the success of the organization.In this paper, an attempt was made to look into theneeds of employees in organizations and in particular,the needs based on Maslow’s theory on motivation. Subjects and Methods: Employees which consisted ofboth academic and administrative employees of theInternational Medical University (...

  4. Il contributo del neuropsicologo alla certificazione medica di idoneità alla guida

    Directory of Open Access Journals (Sweden)

    Mario Zerilli

    2013-08-01

    Full Text Available Pochi giorni fa, una ragazza di appena 22 anni, Giulia, mentre camminava è stata investita da un Suv nella Provincia di Padova e trascinata per circa quattro chilometri senza che la conducente si fosse accorta di nulla. Appare del tutto incredibile come la conducente non si sia accorta per quattro lunghi chilometri del corpo di Giulia, appeso alle lamiere della sua jeep, tra il fanale e la ruota. La conducente non si sarebbe accorta delle urla e dei pugni della sventurata. La ragazza è deceduta (pare per dissanguamento e trauma cranico prima dell’arrivo dei soccorsi. L’investitrice avrebbe parcheggiato alla fine della corsa il mezzo a casa in garage. Questa pare – dalle notizie riportate dai giornali quotidiani – fosse in una delicata situazione sanitaria e sotto l’effetto di farmaci tranquillanti (benzodiazepine. I medici responsabili della prescrizione e l’investitrice sarebbero, sempre secondo i quotidiani, sotto indagine da parte dei magistrati rispettivamente per mancata segnalazione e guida sotto effetto di stupefacenti.

  5. Prevalencia de consumo de tabaco entre las medicas y enfermeras de la comunidad de Madrid

    OpenAIRE

    Fernández Ruiz Mª Luisa; Sánchez Bayle Marciano

    1999-01-01

    FUNDAMENTOS: El tabaquismo es responsable de una elevada mortalidad y morbilidad en nuestro pais. El tabaquismo de los profesionales de la salud tiene influencia sobre los hábitos de la población. En España, el tabaquismo esta incrementándose entre las mujeres. El objetivo de nuestro estudio es estudiar la prevalencia de consumo de tabaco entre las médicas y enfermeras de la Comunidad de Madrid, así como sus actitudes y conocimientos respecto al tabaquismo. MÉTODOS: Se ha realizado un estudio...

  6. Medical intervention in radiological emergencies, formation and training; Intervencion medica en emergencias radiologicas, formacion y adiestramiento

    Energy Technology Data Exchange (ETDEWEB)

    Cardenas H, J. [CPHR, Calle 20 No. 4113, e/41 y 47 Playa, CP 11300, La Habana (Cuba)]. e-mail: cardenas@cphr.edu.cu

    2006-07-01

    The work exposes the national experience in the development of training programs in medical aspects of the radiological emergencies. Implemented after valuing the existent situation, identified the necessities and the reach of the training, additionally it was elaborated the content of the training program whose purpose is guided to the invigoration of the medical answer capacity in radiological emergencies The content of the modular program it approaches theoretical- practical aspects on preparation and medical answer in radiological emergencies. The program includes an exercise that simulates a radiological accident, to evaluate during the same one, the answer capacity before this situation. The training concludes with the design of a strategy for the preparation and answer in radiological emergencies in correspondence with the potential accidental scenarios that the participants can face. (Author)

  7. Quality index in medical radiology; Indice de qualidade em radiologia medica

    Energy Technology Data Exchange (ETDEWEB)

    Travassos, Paulo Cesar B.; Magalhaes, Luis Alexandre Goncalves; Drexler, Gunter G.; Almeida, Carlos E. de, E-mail: luisalexandregm@hotmail.com [Universidade do Estado do Rio de Janeiro (IBRAG/UERJ), RJ (Brazil). Instituto de Biologia. Laboratorio de Ciencias Radiologicas; Navarro, Marcus V. [Instituto Federal de Educacao, Ciencia e Tecnologia da Bahia (IFBA), Salvador, BA (Brazil)

    2012-08-15

    In the literature there are articles with methods for the calculation of potential risk in medical radiodiagnostics institutions: Evaluation Model for Potential Risk (MARP). These articles present results based on documental evaluation of the institutions, but they suggest that quantitative data from the equipment's quality assurance can be included. This article proposes an evaluation of medical radiology institutions with a variation of the Potential Risk model, which considers, besides the administrative factors, quantitative results from equipment's quality assurance: the quality index. Results of the application of this proposition in 42 institutions are presented, with 52 evaluated conventional X-Ray equipment, located in the state of Rio de Janeiro, Brazil. (author)

  8. First-order Derivative Spectrophotometry for the Determination of Vitamin C in Medicament

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A novel method for the determination of vitamin C(Vc) is proposed in this article. After the reaction with Folin-Ciocalteau reagent at ambient temperature, Vc solution was scanned at 750-1100 nm, and its first-order derivative spectrum were obtained from the original spectrum. The values of derivative selected at 995 nm were used for determination. It was proved that Vc could quickly react with Folin-Ciocalteau reagent within 5 min and the product was quite stable for a long time. The conditions required for this method is not very complicated, its precision and accuracy are similar to those of the iodometric titration described in Chinese Pharmacopoeia, and the limit of detection is 0.312μg/mL. The determination of the results of vitamin C tablet, pill, and injection demonstrates that this method has wide pharmaceutical applications.

  9. Perspectivas futuras de las actividades de educación medica continua en Costa Rica

    Directory of Open Access Journals (Sweden)

    Grettchen Flores Sandí

    2004-03-01

    Full Text Available El proceso de educación médica continua se favorecería si los encargados de las actividades consideraran la calidad académica de los docentes, ya que es importante tener en cuenta la comprensión, intereses, motivaciones y actitudes de los médicos y los aspectos del proceso educativo en sí, como las teorías y metodologías de enseñanza y estrategias de evaluación de los aprendizajes que les permitieran cumplir con sus objetivos pedagógicos. Es posible identificar elementos del proceso educativo que deben incluirse en los programas de Educación Médica Continua, tales como: definir objetivos de aprendizaje, técnicas metodológicas y de evaluación de los aprendizajes, tiempo requerido para abarcar los contenidos y definir el perfil idóneo de los asistentes y del docente que participa en este tipo de programas, siempre en aras de la mejora del proceso enseñanza-aprendizaje. Tanto los encargados como los docentes de estas actividades deben estar calificados para realizar los procesos que hacen posible el desarrollo de la acción educativa: análisis de necesidades, programación, diseño y elaboración de metodologías, ejecución de técnicas, evaluación y seguimiento de los aprendizajes. Además, los encargados deben estar conscientes de que en el proceso enseñanza-aprendizaje intervienen el alumno, el docente y una situación de aprendizaje y en este sentido esta tríada se convierte en la protagonista sujeta a evaluación. El proceso de capacitación a encargados debe orientarse, entre otros, a dotarlos de habilidades para mejorar la calidad del proceso enseñanza-aprendizaje, como la comunicación eficiente, la actitud crítica e investigativa y desarrollar las habilidades de evaluación de los aprendizajes.The process of continued medical education would be favored if the people in charge of this activities consider the academic quality of the teachers, because is important have in mind the comprehension, interests, motivations and attitudes of the doctors and the aspects of the educative process, such as the theories and teaching and evaluation methods that allow them to accomplish their pedagogical objectives. It is possible to identify elements of the educative projects that need to be included in the programs of Continued Medical Education, for instance: define learning objectives, methodological techniques and evaluation techniques of the acquired knowledge, the required time to complete the contents and define the proper profile of the assistants and of the teacher who participates in this types of programs, always trying to improve the learning / teaching process. Both have to be qualified - the people in charge and the teachers of these activities - to carry out the processes that make the development of the educational action possible: analysis of the needs, programming, design and elaboration of methodologies, technique execution, evaluation, and follow up of the acquired knowledge. Moreover, the people in charge must be aware that the learning - teaching process involves the student, the teacher, and a learning situation, and in this way this triad becomes the subject of evaluation. The capacitating process to the people in charge must be oriented, among others, to empower their abilities to improve the quality of the teaching - learning process, enhance efficient communication, increase critical and investigative attitudes, and develop the evaluation abilities of the acquired knowledge.

  10. Prevalencia de consumo de tabaco entre las medicas y enfermeras de la comunidad de Madrid

    Directory of Open Access Journals (Sweden)

    Fernández Ruiz Mª Luisa

    1999-01-01

    Full Text Available FUNDAMENTOS: El tabaquismo es responsable de una elevada mortalidad y morbilidad en nuestro pais. El tabaquismo de los profesionales de la salud tiene influencia sobre los hábitos de la población. En España, el tabaquismo esta incrementándose entre las mujeres. El objetivo de nuestro estudio es estudiar la prevalencia de consumo de tabaco entre las médicas y enfermeras de la Comunidad de Madrid, así como sus actitudes y conocimientos respecto al tabaquismo. MÉTODOS: Se ha realizado un estudio descriptivo transversal entre las mujeres profesionales de la salud (médicas y enfermeras de la Comunidad de Madrid, mediante una encuesta sobre hábito tabáquico, en un muestreo polietápico por conglomerados. RESULTADOS: Se han estudiado 1.235 profesionales ( 435 médicas y 800 enfermeras. El 43,07% del total son fumadoras, siendo el tabaquismo mayor en las enfermeras (47,62% que en las médicas (34,71%, y entre quienes trabajan en atención especializada (46,68% que entre las que lo hacen en atención primaria (35,29%. El tabaquismo fue diferente en ambas profesiones.según la edad En las médicas era menor tabaquismo en las edades entre 20 y 30 años (22,88%, y en las enfermeras este grupo de edad era el que tenia un mayor porcentaje de fumadoras (52,38%. Eran exfumadoras el 18,3% del total de las encuestadas, y el 64,65% de las que fumaban señalaron que habían intentado dejarlo. Un 2,93% fumaban delante de los/as pacientes, y un 14,94% pensaban que debía permitirse fumar en las salas de espera. El 27,46% creían que estaba permitido fumar en su area de trabajo, y el 90,64% señaló que se fumaba habitualmente en las salas de uso común del personal sanitario, y un 30,37% respondió que existía un lugar especifico para fumar en el centro de trabajo. CONCLUSIONES: La prevalencia de tabaquismo entre las profesionales de la salud, médicas y enfermeras, de la Comunidad de Madrid, es elevada, superior a la de la población general de igual edad y genero. El tabaquismo entre las enfermeras es más frecuente que entre las médicas, y en los hospitales que en Atención Primaria, y entre las enfermeras en el grupo más joven, lo que es muy preocupante. El cumplimiento de la legislación sobre tabaco en los centros sanitarios parece muy bajo.

  11. Ethnic Differences And Motivation Based On Maslow’s Theory At a MedicaL University

    Directory of Open Access Journals (Sweden)

    Jagmohni Kaur Sidhu

    2007-06-01

    Full Text Available Introduction: Motivation in Malaysia is to a largeextent influenced by the value system amongst allMalaysians. Being able to motivate employees is one ofthe important keys to the success of the organization.In this paper, an attempt was made to look into theneeds of employees in organizations and in particular,the needs based on Maslow’s theory on motivation. Subjects and Methods: Employees which consisted ofboth academic and administrative employees of theInternational Medical University (IMU were surveyedusing a standard questionnaire. The aim of this studywas to compare which levels of Maslow’s hierarchy ofneeds theory had been fulfilled and which needs wereyet to be fulfilled in the different ethnic groups at IMU. Results: Amongst the males, the Chinese and Indianethnic groups placed most emphasis on the esteem needsand on self-actualization needs. The Malay males gaveimportance to Safety needs. Amongst the female ethnicgroups, all three groups placed most importance on theesteem needs and self-actualization needs. The Chinesefemales scored the lowest for the Basic needs comparedto the Malay and Indian females. The Indian femalesscored the lowest for Social needs.Conclusion: Organisations should play an importantrole in the motivation of employees. Human resourcedevelopment is an integral part in the development ofits employees.

  12. Comparison of five preanesthetic medicaments in thiopental-anesthetized cats: antagonism by selected compounds.

    Science.gov (United States)

    Hatch, R C; Kitzman, J V; Zahner, J M; Clark, J D

    1984-11-01

    Effects of IM injections of saline solution (groups 1, 2, 3, and 4), xylazine (2.2 mg/kg of body weight, groups 5 and 6), acepromazine (0.11 mg/kg, groups 7 and 8), ketamine (11 mg/kg, groups 9 and 10), meperidine (4.4 mg/kg, groups 11 and 12), and diazepam (1 mg/kg, groups 13 and 14) were compared in atropinized cats. Treated cats were anesthetized to loss of palpebral reflex with thiopental, IV. Within 2 minutes, the cats were given IV injections of 0.15 mg of 4-aminopyridine (4-AP) with 0.125 mg of yohimbine/kg (groups 2, 6, 8, and 10), 0.04 mg of naloxone/kg (groups 3 and 12), or 5 mg of the benzodiazepine antagonist Ro 15-1788/kg (groups 4 and 14). Groups 1, 5, 7, 9, 11, and 13 were given saline solution instead of the test antagonists. Required doses of thiopental, arousal time, walk time (measured from injection of antagonists), respiratory rate, and heart rate were recorded. Induction phenomena were also recorded. Emergence was graded as smooth, fairly smooth, fairly smooth in some cats to fairly rough in other cats, rough, or very rough. In group 1 cats, mean arousal time (MAT) was 20.1 minutes, mean walk time (MWT) was 50 minutes, and emergence was rough. In groups given saline solution as the antagonist, the MAT, MWT (both expressed in minutes), and emergence, respectively, were: group 5 = 52.5, 65.5, smooth; group 7 = 15.6, 36.2, fairly smooth; group 9 = 22.5, 58.1, rough; group 11 = 31.3, 52.7, fairly smooth to fairly rough; and group 13 = 91.8, 427, very rough.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:6151814

  13. PRACTICAS MEDICAS, PRACTICAS POLITICAS. ROSAS Y LA «VACUNA INDIGENA»

    Directory of Open Access Journals (Sweden)

    MARÍA SILVIA DI LISCIA

    2011-10-01

    Full Text Available BUENOS AIRES, 1830. Se declara una epidemia de viruela entre los indios «pampas» que están en la ciudad para honrar al Restaurador de las Leyes. Los caciques no disimulan su admiración ante la valentía de Rosas, quien los visita sin alarma ante el contagio y los estimula a vacunarse para eliminar el temible mal. Un número estimado en más de cien indios acepta, entonces, inmunizarse, colocándose, según el testimonio de Parish, la «vacuna a indígenas ». Buenos Aires, 1833. Francisco X. Muñiz, médico de la campaña bonaerense, inicia las investigaciones con las que diez años después se logra el redescubrimiento del cow pox, es decir, la viruela vacuna, llamada por Sarmiento «la vacuna indígena».

  14. Perspectivas futuras de las actividades de educación medica continua en Costa Rica

    OpenAIRE

    Grettchen Flores Sandí

    2004-01-01

    El proceso de educación médica continua se favorecería si los encargados de las actividades consideraran la calidad académica de los docentes, ya que es importante tener en cuenta la comprensión, intereses, motivaciones y actitudes de los médicos y los aspectos del proceso educativo en sí, como las teorías y metodologías de enseñanza y estrategias de evaluación de los aprendizajes que les permitieran cumplir con sus objetivos pedagógicos. Es posible identificar elementos del proceso educativo...

  15. Le nuove scoperte e il nuovo contesto della ricerca bio-medica

    OpenAIRE

    Di Bernardo, Mirko

    2011-01-01

    The article focuses on the cultural ambience which, between the second half of the eigh-teenth century and the first half of the nineteenth century, mainly in Germany and partly in France, has been the theatre of that very medical-scientific revolution – a revolution connected to G. Reinold Treviranus’ biology, A. von Haller and F. J. Gall’s experimental works, L. Pasteur’s germ theory, as well as R. Virchow’s cellular pathology, Cabanis and De Tracy’s researches and C. Bernard’s experimental...

  16. Percentage of Swarna Bhasma in medicaments of Ayurveda to treat disorders of different origin

    Directory of Open Access Journals (Sweden)

    Kapil Deo Yadav

    2015-01-01

    Full Text Available Swarna (gold has been used to enhance strength and potency, promote longevity and combat the aging process in humans. It is used as pure metal, bhasma and other dosages form by ancient to the contemporary sciences for therapeutic purposes. In Brihatrayi, it was mainly used externally for the formation of yantra etc., and after development of shodhan, maran (Rasa Shastra procedure process, internal use become possible in wide range of disorders like Jwara (Fever, Yakshma (tuberculosis, Prameha (diabetes, Vata Vyadhi (neurological disorders and diseases of gastrointestinal tracts with varying percentage. These disorders are developed either by pathogens which may be bacteria, virus, fungi etc., or due to disturbances in person immunity. Swarna formulations having <10% of swrana was used in disorders mainly caused by pathogens like yakhsma, diseases of gastrointestinal tracts and formulation having 11-20% of swarna for disorders like Vata vyadhi, Prameha which may be developed mainly due to disturbance of immunity at any stage of disease process. Formulations having <10% as well as between 11% and 20% of swarna were indicated in Jwara that may occur either pathogens or disturbances in immunity.

  17. CORRECTION OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH CHRONIC COR PULMONALE BY ANGIOTENSIN II RECEPTORS ANTAGONISTS

    Directory of Open Access Journals (Sweden)

    V. S. Zadionchenko

    2007-01-01

    Full Text Available Aim. To evaluate intensity of endothelial dysfunction, processes of apoptosis, state of central and peripheral hemodynamics and to evaluate how these characteristics are influenced by angiotensin II receptors antagonists (ARA II – candesartan (Atacand and losartan (Cosaar in patients with chronic cor pulmonale (CCP at different stages of disease.Material and methods. 100 patients with chronic obstructive pulmonary disease (COPD, complicated by CCP were included into the study. Caspase activity as apoptosis induction marker, von Willebrand factor, production of nitric oxide in blood plasma and condensate of breathing out air were assessed. 70 patients received ARA II (50 patients – candesartan 4-8 mg daily, 20 patients – losartan 50-100 mg daily, 30 patients received neither ARA II nor angiotensin converting enzyme inhibitors (ACEI.Results. Significant increase in intensity of endothelial dysfunction and activation of apoptosis processes were registered according to growth of CCP severity. After 6 months of therapy von Willebrand factor decreased by 25,2% and 27,7% in candesartan and losartan groups respectively (p<0.01 for both groups. In the control group only 13.2% of von Willebrand factor reduction was seen.Conclusion. ARA II added to common therapy of COPD complicated by CCP improves functional state of endothelium restricting hyperproduction of nitric oxide and its toxic effects and slowing down apoptotic cell death.

  18. CORRECTION OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH CHRONIC COR PULMONALE BY ANGIOTENSIN II RECEPTORS ANTAGONISTS

    Directory of Open Access Journals (Sweden)

    V. S. Zadionchenko

    2015-12-01

    Full Text Available Aim. To evaluate intensity of endothelial dysfunction, processes of apoptosis, state of central and peripheral hemodynamics and to evaluate how these characteristics are influenced by angiotensin II receptors antagonists (ARA II – candesartan (Atacand and losartan (Cosaar in patients with chronic cor pulmonale (CCP at different stages of disease.Material and methods. 100 patients with chronic obstructive pulmonary disease (COPD, complicated by CCP were included into the study. Caspase activity as apoptosis induction marker, von Willebrand factor, production of nitric oxide in blood plasma and condensate of breathing out air were assessed. 70 patients received ARA II (50 patients – candesartan 4-8 mg daily, 20 patients – losartan 50-100 mg daily, 30 patients received neither ARA II nor angiotensin converting enzyme inhibitors (ACEI.Results. Significant increase in intensity of endothelial dysfunction and activation of apoptosis processes were registered according to growth of CCP severity. After 6 months of therapy von Willebrand factor decreased by 25,2% and 27,7% in candesartan and losartan groups respectively (p<0.01 for both groups. In the control group only 13.2% of von Willebrand factor reduction was seen.Conclusion. ARA II added to common therapy of COPD complicated by CCP improves functional state of endothelium restricting hyperproduction of nitric oxide and its toxic effects and slowing down apoptotic cell death.

  19. Influence of different light-curing units on the surface roughness of restorative materials: in situ study

    Directory of Open Access Journals (Sweden)

    Juliane Cristina Ciccone-Nogueira

    2007-09-01

    Full Text Available The aim of this study was to evaluate the influence of different light sources (LED and Halogen lamp on the roughness (superficial of composite resin (Filtek Z250, Filtek P60, Charisma and Durafill varying post-irradiation times, in an in situ experiment. For this purpose, 80 specimens were made in polyurethane moulds. Ten volunteers without medicament use and good oral condition were selected and from them study moulds were obtained. A palatal intra-oral acrylic resin appliance was made for each of the subjects of the experiment. In each appliance, two specimens of each material were fixed (LED/Halogen lamp - control group. Roughness tests were performed immediately and 30 days after initial light-curing. Statistical analysis was performed using ANOVA. Statistically significant difference was observed only between post-irradiation times, where the 30th day showed the highest roughness values. It be concluded that roughness was influenced only by post-irradiation times, presenting the 30- days period inferior behavior.

  20. Calcium hydroxide: study based on scientific evidences Hidróxido de cálcio: estudo baseado em evidências científicas

    Directory of Open Access Journals (Sweden)

    Carlos Estrela

    2003-12-01

    Full Text Available The characteristics of calcium hydroxide come from its dissociation into calcium and hydroxyl ions. The action of these ions on tissues and bacteria explains the biological and antimicrobial properties of this substance. Under the conditions of this retrospective of literature, based on scientific evidences, it is possible to state that: 1. Dentin is considered the best pulpal protective, and calcium hydroxide has proved, through numerous studies, its capability of inducing the formation of a mineralized bridge over pulpal tissue. 2. It is necessary, whenever possible, to provide time for calcium hydroxide paste to manifest its potential of action on the microorganisms present in endodontic infections. The maintenance of a high concentration of hydroxyl ions can change bacteria enzymatic activity and promote its inactivation. 3. The site of action of hydroxyl ions of calcium hydroxide includes the enzymes in the cytoplasmic membrane. This medication has a large scope of action, and therefore is effective on a wide range of microorganisms, regardless their metabolic capability. In microbial world, cytoplasmic membranes are similar, irrespective from microorganisms morphological, tinctorial and respiratory characteristics, which means that this medication has a similar effect on aerobic, anaerobic, Gram-positive and Gram-negative bacteria. 4. Calcium hydroxide as temporary dressing used between appointments promotes better results on the periapical healing process than the treatment in one appointment.As características do hidróxido de cálcio se desenvolvem a partir da dissociação em íons cálcio e hidroxila. A ação desses íons nos tecidos e bactérias explica as características biológicas e antimicrobianas dessa substância. Por meio desta retrospectiva da literatura, baseada em evidências científicas, é possível afirmar que: 1. A dentina é considerada a melhor proteção pulpar, e o hidróxido de cálcio provou, através de

  1. Hyperkalemia associated with irbesartan and candesartan cilexetil%厄贝沙坦、坎地沙坦酯相关高钾血症

    Institute of Scientific and Technical Information of China (English)

    何勇; 徐秀云

    2010-01-01

    1例76岁女性患者,因急性脑梗死和原发性高血压应用尼莫地平、氯吡格雷、曲克芦丁及奥拉西坦治疗.入院第3天为控制血压加用厄贝沙坦0.15 g,1次/d.治疗7 d后患者BP 125/60 mm Hg,病情好转出院.出院后继续服用氯吡格雷25 mg、2次/d,尼群地平15 mg、3次/d,尼莫地平40 mg、2次/d,氢氯噻嗪12.5 mg、1次/d,厄贝沙坦0.15 mg、1次/d.出院第5天,门诊复查肾功能示BUN 14.42 mmoL/L、SCr 114.0 μmol/L、K+6.89 mmol/L,BP 150/70 mm Hg.诊断为高钾血症,再次入院.给予利尿、排钾治疗.考虑血钾升高与降压药有关,停用厄贝沙坦、尼群地平,改服硝苯地平控释片30 mg,1次/d.3天后患者血钾和肾功能恢复正常,出院.追踪病史,患者约1年前曾服用坎地沙坦酯并出现血钾升高.

  2. Antibacterial effect of triantibiotic mixture, chlorhexidine gel, and two natural materials Propolis and Aloe vera against Enterococcus faecalis: An ex vivo study

    Directory of Open Access Journals (Sweden)

    Leila Bazvand

    2014-01-01

    Full Text Available Background: The aim of this ex vivo study was to compare the antimicrobial effect of triantibiotic paste, 0.2% chlorhexidine gel, Propolis and Aloe vera on Enterococcus faecalis in deep dentin. Materials and Methods: Ninety fresh extracted single-rooted teeth were used in a dentin block model. Seventy-five teeth were infected with E. faecalis and divided into four experimental groups (n = 15. Experimental groups were treated with triantibiotic mixture with distilled water, 0.2% chlorhexidine gel, 70% ethanol + Propolis and Aloe vera. Fifteen teeth treated with distilled water as the positive control and 15 samples, free of bacterial contamination, were considered as the negative control. Gates-Glidden drill #4 was used for removal of surface dentin and Gates-Glidden drill #5 was used to collect samples of deep dentin. The samples were prepared and colony-forming units were counted. Data were analyzed by one-way ANOVA and post hoc Tukey tests. Statistical significance was defined at P 0.05. Aloe vera had antibacterial effects on E. faecalis, but in comparison with other medicaments, it was less effective (P < 0.05. Conclusion: This experimental study showed that triantibiotic mixture, 0.2% chlorhexidine gel, Propolis and Aleo vera were relatively effective against E. faecalis. All the intracanal medicements had similar effects on E. faecalis in deep dentin except for Aloe vera.

  3. Scientometric Analysis of the Journals of the Academy of Medical Sciences in Bosnia and Herzegovina

    OpenAIRE

    Masic, Izet; Begic, Edin; Zunic, Lejla

    2016-01-01

    Introduction: Currently in Bosnia and Herzegovina there are 25 journals in the field of biomedicine, 6 of them are indexed in Medline/PubMed base (Medical Archives, Materia Socio-Medica, Acta Informatica Medica, Acta Medica Academica, Bosnian Journal of Basic Medical Sciences (BJBMS) and Medical Glasnik), and one (BJBMS) is indexed in Science Citation Index Expanded (SCIE)/Web of Science base. Aim: The aim of this study was to show the scope of work of the journals that were published by Acad...

  4. [Study on two manuscripts with colored illustrations collected in France].

    Science.gov (United States)

    Liu, Yu-Ping; Cao, Hui

    2013-09-01

    Two manuscripts with colored illustrations in French libraries were investigated. The research showed that: the first manuscript with colored pictures include 2 volumes, titled Animaux et Plantes de Chine collected in Library of Museum National d'Historie Naturelle (MNHN);the other manuscript with colored pictures has only 1 volume, titled Botanique Chinoise collected in Library of Societe Asiatique, College de France, which were identified as illustrations of Ben cao gang mu (Compendium of Materia Medica) (1640 edition) by Li Shi-zhen. These pictures were copied by P. d'Incarville, and are similar to Plantes fleurs et arbres de Chine in Bibliotheque de l'Institut de Franceand, Collection de Plantes Veneneuses de la Chine Gravees et Imprimees en Couleurs par les Missionnaries Jesuites in Bibliotheque Nationale de France, respectively. The latter two manuscripts were identified as illustrations of Ben cao pin hui jing yao (Essential Collections of Materia Medica) (1700 edition).

  5. Studies on the anti-diarrheal properties of seed extract of Monodora tenuifolia

    Directory of Open Access Journals (Sweden)

    M O Ezenwali

    2009-12-01

    Full Text Available Summary: The anti-diarrheal effect of methanol extract (ME of seeds of Monodora tenuifolia Benth (Annonaceae, a wildly growing orchid flowering tree whose seed is traditionally used as antidiarrhea remedy, was studied using rodent models of diarrhea, enteropooling and gastrointestinal motility induced by castor oil. Acute toxicity and lethality (LD50 and phytochemical constituents of ME were also evaluated. The results showed that ME significantly (P<0.05 reduced the watery texture and number of fecal droppings over 4 h. It also significantly (P<0.05 reduced the volume and weight of intestinal content in a non-dose-related manner. On gastro-intestinal motility, ME significantly (P<0.05 reduced the small intestinal transit of charcoal meal in mice induced by castor oil in a non-dose-related manner. Phytochemical analysis showed that ME tested positive to carbohydrates, saponins, proteins, resins, flavonoids, alkaloids, terpenoids, steroids, fats and oil. Acute toxicity and lethality studies on ME revealed an oral LD50 greater than 5000 mg/kg in mice. These results showed that seeds of M. tenuifolia possess anti-diarrheal properties mediated through inhibition of hyper-secretion and gastrointestinal motility which substantiate the use in the treatment of diarrhea in traditional medicine. Industrial relevance: The industrial relevance of findings from this study derives from the possibility of formulating the powdered seed of this plant or its alcohol extract, into a herbal anti-diarrhea remedy. From this study and the age long use as condiment, toxicity may not preclude use as a medicament.

  6. Clinical and radiographic assessment of mineral trioxide aggregate and calcium hydroxide as apexification agents in traumatized young permanent anterior teeth: A comparative study

    Science.gov (United States)

    Damle, S. G.; Bhattal, Hiteshwar; Damle, Dhanashree; Dhindsa, Abhishek; Loomba, Ashish; Singla, Sumit

    2016-01-01

    Background: To evaluate and compare the efficacy of mineral trioxide aggregate (MTA) and traditionally used calcium hydroxide (Ca(OH)2) in inducing root end formation of immature roots of traumatized young permanent anterior teeth. Materials and Methods: The study was carried out on 22 nonvital, immature permanent maxillary incisors. Samples were allotted into two groups - Group I MTA and Group II Ca(OH)2 Success rate was determined based upon the time duration required for apical barrier formation. The canals were obturated using gutta-percha points in MTA group, after 24 h, whereas in Ca(OH)2 group, obturation was carried out after radiographic confirmation of the apical barrier. The clinical and radiographic evaluation was carried out at a follow-up periods of 3, 6, and 9 months and statistical analysis was carried out by SPSS version 15.0 statistical analysis software (Chi-square test and fisher exact test). Results: In MTA Group, barrier formation was observed in 90.90% of the patients after 9 months whereas in Ca(OH)2 Group, the same was observed in 81.81%. The mean time required for barrier formation in MTA group was 4.90 months and 5.33 months in Ca(OH)2 group. Conclusion: MTA and Ca(OH)2, as medicaments for apexification, were comparable in terms of the evaluation parameters. However, MTA was beneficial in terms of immediate obturation of immature roots with wide open apices. PMID:27274351

  7. Comparative evaluation of antimicrobial activity of hydroalcoholic extract of Aloe vera, garlic, and 5% sodium hypochlorite as root canal irrigants against Enterococcus faecalis: An in vitro study

    Directory of Open Access Journals (Sweden)

    Swati Ramesh Karkare

    2015-01-01

    Full Text Available Introduction: Enterococcus faecalis are the most resistant and predominant microorganisms recovered from root canals of teeth where previous treatment has failed. Over the past decade, interest in drugs derived from medicinal plants has markedly increased. In dentistry, phytomedicines has been used as an anti-inflammatory, antibiotic, analgesic, sedative, and also as an endodontic irrigant. In endodontics, because of the cytotoxic reactions of most of the commercial intracanal medicaments and their inability to eliminate bacteria completely from dentinal tubules, the trend is shifting toward use of biologic medication extracted from natural plants. Aim: To compare the antimicrobial efficacy of newer irrigating agents which would probably be as effective or more and at the same time less irritating to the tissues than sodium hypochlorite (NaOCl. The objective of this study was to compare the antimicrobial activity of saturated and diluted (1:1 hydroalcoholic extract of Aloe vera, garlic, and 5% NaOCl against E. faecalis using the commonly used agar diffusion method. Results: Saturated hydroalcoholic extract of A. vera showed the highest zone of inhibition against E. faecalis. NaOCl, which is considered as gold standard, also showed higher zones of inhibition.

  8. A STUDY OF FETAL OUTCOME IN OLIGOHYDRAMNIOS (AFI BETWEEN 0 - 7

    Directory of Open Access Journals (Sweden)

    Krishnaveni

    2015-03-01

    Full Text Available OBJECTIVES: Amniotic fluid Volume (AFV is an important indicator of fetal well - being Oligohydramnios affects 0.5 to 5% of the pregnancy. In presence of Oligohydramnios if the AFI is 0 - 7 the fetal outcome is not good. If the AFI <5 which needs immediate delivery irrespective of the NST results. So the cases selected between AFI 0 - 7 a re directly taken to LSCS. To know the fetal outcome associated with Oligohydramnios (AFI 0 - 7. MATERIALS AND METHODS: This is a prospective study. The study group consisted of 67 pregnant cases selected from Vanivilas Hospital attached to Bangalore Medica l College and Research Institute, Bangalore. The cases were studied between the periods 15 th November 2014 to 1 st March 2015. These 67 in patients were selected for emergency OT directly because of variable AFI (0 - 7. Based on this fetal outcome is assesse d. The AFI was totally based on USG report on admission and these cases was referred from outside to Vanivilas Hospital because this hospital is a tertiary care center where emergency OT is working round the clock. RESULTS: Out of 67 cases in the present s tudy group there was not even one fetal mortality. The birth weight was varying from 1.4 kg to 3.2 kg out of these two babies needed stimulation after extraction in the OT their birth weight was 1.4 kg and 1.6 kg. There was meconium in 17 cases (thick meco nium 12 cases, thin meconium 5 cases. Anhydramnios (nil liquor 3 cases, NICU admissions (16. CONCLUSION: Oligohydramnios (AFI between 0 - 7 is an important indication for emergency LSCS without depending on NST which can result in good fetal outcome in a tertiary center like VVH. So the mortality and morbidity of the fetus can be avoided if we decide for emergency LSCS

  9. Study of Chemical Constituents and Medicinal Uses of Indicator Species of District Bannu

    Directory of Open Access Journals (Sweden)

    Rehman ullah khan

    2013-06-01

    Full Text Available The present study was carried out to assess record and report the chemical constituents and ethnobotanical knowledge of indicator species of District Bannu. Medicinal outlines of about 57 plants were recorded through interview local people i.e. farmers, herbalists, hakims and Medicinal plants user dealers. The present investigation comprises the indigenous uses of 57 species belonging to 36 families of Angiosperms based upon their utility. Out of this rich Medicinal germplasm, 66.15% plants are wild while 44.18%, species were found to be cultivated, 26.74% species are both wild and cultivated of the total flora of this area. The most important medicinal families are Solanaceae (7 spp, 12.28%, Asteraceae (5 spp, 8.77%, Mimosaceae (3 spp, 5.26%, Moraceae (3 spp, 5.26%, Malvaceae, Amaranthaceae, Chenopodiaceae, Euphorbiaceae, Papilionaceae, Plantaginaceae, and Rhamnaceae (2 spp, 3.51% While the remaining 25 families having 1 species each which is 1.75% of all families. The most common medicinal plants in the area are Abroma augusta (L. F., Acacia modesta wall., Achyranthes bidentata Blume , Albizia lebbeek L., Calotropis procera L., Capparis decidua Forsk Carthamus oxycantha M. B, Chenopodium album L., Citrus medica L., Citrullus colocynthis Schrad, Cuscuta reflexa Roxb, Cynodon dactylon L. Cyperus rotundrus L., Dodonia viscosa L., Eucalyptus globule L., Nerium oleander L., Papaver somniferum L., Trachy spermum ammi L. Typha orientallis J. Preslw., Vitex negundo L., Withania somnifera L., Xanthium strumarium L., Zizphus mauratiana Lam., Some plants have wild fruits i.e.., Solanum nigrum L., while Nerium oleander L. and Dodonaea viscosa (L. Jaeq are ornamental.

  10. Medications Errors and Health-Related Quality of Life of Nursing Professionals in Intensive Care Units Errores de medicación y calidad de vida relacionada a la salud de profesionales de enfermería en Unidades de Terapia Intensiva Erros de medicação e qualidade de vida relacionada à saúde de profissionais de enfermagem em unidades de terapia intensiva

    OpenAIRE

    Josikélem da Silva Sodré Pelliciotti; Miako Kimura

    2010-01-01

    This study identifies the prevalence of medication errors in ICUs reported by nursing professionals, compares the health-related quality of life (HRQoL) and health status changes of those professionals both involved and not involved with medication errors in ICUs. A total of 94 nursing professionals in three ICUs of a private hospital were studied: 39 (41.5%) nurses and 55 (58.5%) nursing technicians. HRQoL was assessed through the Portuguese version of the SF-36 instrument. Eighteen professi...

  11. Chemical constituent and antimicrobial effect of essential oil from Myrtus communis leaves on microorganisms involved in persistent endodontic infection compared to two common endodontic irrigants: An in vitro study

    Directory of Open Access Journals (Sweden)

    Mohammadreza Nabavizadeh

    2014-01-01

    Full Text Available Introduction: Persistent infections of human root canals play a fundamental role in the failure of endodontic treatment. The purpose of this study is to determine the chemical composition of Myrtus communis (M. communis essential oil and to assess its antimicrobial activity against Enterococcus faecalis, Staphylococcus aureus and Candida albicans compared to that of sodium hypochlorite (NaOCl and chlorhexidine (CHX. Materials and Methods: Gas chromatography-mass spectrometry (GC-MS was used to determine the chemical composition of essential oil from M. communis leaves. A micro-dilution susceptibility assay and disk diffusion methods were utilized to evaluate the antimicrobial activity [minimum inhibitory concentration (MIC and minimum lethal dose concentration] of the tested solutions against selected microorganisms. Results: GC-MS analyses revealed that M. communis contained 1, 8-Cineole (28.62%, α-Pinene (17.8%, Linalool (17.55%, and Geranylacetate (6.3% as the major compounds and Geraniol (1.6%, α-Humulene (1.5%, eugenol (1.3%, isobutyl-isobutyrate (0.8%, and methyl chavicol (0.5% as minor components. Chlorhexidine had the lowest MIC value among all medicaments tested. M. communis oil had less MIC values than NaOCl against both bacteria, but it had more MIC value against C. albicans. Conclusion: M. communis essential oil with the minimum inhibitory concentration in the range of 0.032-32 μg/mL was an effective antimicrobial agent against persistent endodontic microorganisms.

  12. Benefits and risks of testosterone treatment for hypoactive sexual desire disorder in women: a critical review of studies published in the decades preceding and succeeding the advent of phosphodiesterase type 5 inhibitors.

    Science.gov (United States)

    Reis, Sandra Léa Bonfim; Abdo, Carmita H N

    2014-01-01

    With advancing age, there is an increase in the complaints of a lack of a libido in women and erectile dysfunction in men. The efficacy of phosphodiesterase type 5 inhibitors, together with their minimal side effects and ease of administration, revolutionized the treatment of erectile dysfunction. For women, testosterone administration is the principal treatment for hypoactive sexual desire disorder. We sought to evaluate the use of androgens in the treatment of a lack of libido in women, comparing two periods, i.e., before and after the advent of the phosphodiesterase type 5 inhibitors. We also analyzed the risks and benefits of androgen administration. We searched the Latin-American and Caribbean Health Sciences Literature, Cochrane Library, Excerpta Medica, Scientific Electronic Library Online, and Medline (PubMed) databases using the search terms disfunção sexual feminina/female sexual dysfunction, desejo sexual hipoativo/female hypoactive sexual desire disorder, testosterona/testosterone, terapia androgênica em mulheres/androgen therapy in women, and sexualidade/sexuality as well as combinations thereof. We selected articles written in English, Portuguese, or Spanish. After the advent of phosphodiesterase type 5 inhibitors, there was a significant increase in the number of studies aimed at evaluating the use of testosterone in women with hypoactive sexual desire disorder. However, the risks and benefits of testosterone administration have yet to be clarified. PMID:24714838

  13. Benefits and risks of testosterone treatment for hypoactive sexual desire disorder in women: a critical review of studies published in the decades preceding and succeeding the advent of phosphodiesterase type 5 inhibitors

    Directory of Open Access Journals (Sweden)

    Sandra Léa Bonfim Reis

    2014-04-01

    Full Text Available With advancing age, there is an increase in the complaints of a lack of a libido in women and erectile dysfunction in men. The efficacy of phosphodiesterase type 5 inhibitors, together with their minimal side effects and ease of administration, revolutionized the treatment of erectile dysfunction. For women, testosterone administration is the principal treatment for hypoactive sexual desire disorder. We sought to evaluate the use of androgens in the treatment of a lack of libido in women, comparing two periods, i.e., before and after the advent of the phosphodiesterase type 5 inhibitors. We also analyzed the risks and benefits of androgen administration. We searched the Latin-American and Caribbean Health Sciences Literature, Cochrane Library, Excerpta Medica, Scientific Electronic Library Online, and Medline (PubMed databases using the search terms disfunção sexual feminina/female sexual dysfunction, desejo sexual hipoativo/female hypoactive sexual desire disorder, testosterona/testosterone, terapia androgênica em mulheres/androgen therapy in women, and sexualidade/sexuality as well as combinations thereof. We selected articles written in English, Portuguese, or Spanish. After the advent of phosphodiesterase type 5 inhibitors, there was a significant increase in the number of studies aimed at evaluating the use of testosterone in women with hypoactive sexual desire disorder. However, the risks and benefits of testosterone administration have yet to be clarified.

  14. The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies

    Directory of Open Access Journals (Sweden)

    Liyuan Han

    2014-01-01

    Full Text Available Aims. Published data on the associations of VEGF polymorphisms with diabetic retinopathy (DR susceptibility are inconclusive. A systematic meta-analysis was undertaken to clarify this topic. Methods. Data were collected from the following electronic databases: PubMed, Embase, OVID, Web of Science, Elsevier Science Direct, Excerpta Medica Database (EMBASE, and Cochrane Library with the last report up to January 10, 2014. ORs and 95% CIs were calculated for VEGF–2578C/A (rs699947, –1154G/A (rs1570360, –460T/C (rs833061, −634G>C (rs2010963, and +936C/T (rs3025039 in at least two published studies. Meta-analysis was performed in a fixed/random effect model by using the software STATA 12.0. Results. A total of 11 studies fulfilling the inclusion criteria were included in this meta-analysis. A significant relationship between VEGF+936C/T (rs3025039 polymorphism and DR was found in a recessive model (OR = 3.19, 95% CI = 1.20–8.41, and P(z=0.01 in Asian and overall populations, while a significant association was also found between –460T/C (rs833061 polymorphism and DR risk under a recessive model (OR = 2.12, 95% CI = 1.12–4.01, and P(z=0.02. Conclusions. Our meta-analysis demonstrates that +936C/T (rs3025039 is likely to be associated with susceptibility to DR in Asian populations, and the recessive model of –460T/C (rs833061 is associated with elevated DR susceptibility.

  15. Environ: E00622 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available E00622 Citrus medica flower Crude drug Citrus medica [TAX:171251] Rutaceae (rue fam...ily) Citrus medica flower (dried) Crude drugs [BR:br08305] Dicot plants: rosids Rutaceae (rue family) E00622 Citrus medica flower ...

  16. Bradykinin antagonist counteracts the acute effect of both angiotensin-converting enzyme inhibition and of angiotensin receptor blockade on the lower limit of autoregulation of cerebral blood flow

    DEFF Research Database (Denmark)

    Sigurdsson, Sigurdur T; Paulson, Olaf B; Høj Nielsen, Arne;

    2014-01-01

    The lower limit of autoregulation of cerebral blood flow (CBF) can be modulated with both angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB). The influence of bradykinin antagonism on ARB-induced changes was the subject of this study. CBF was measured in Sprague......-Dawley rats with laser Doppler technique. The blood pressure was lowered by controlled bleeding. Six groups of rats were studied: a control group and five groups given drugs intravenously: an ACE inhibitor (enalaprilat), an ARB (candesartan), a bradykinin-2 receptor antagonist (Hoe 140), a combination...

  17. Bioactive protein fraction DLBS1033 containing lumbrokinase isolated from Lumbricus rubellus: ex vivo, in vivo, and pharmaceutic studies

    Directory of Open Access Journals (Sweden)

    Tjandrawinata RR

    2014-09-01

    Full Text Available Raymond R Tjandrawinata,1 Jessica Trisina,1 Puji Rahayu,1 Lorentius Agung Prasetya,1 Aang Hanafiah,2 Heni Rachmawati3 1Dexa Laboratories of Biomolecular Sciences, Dexa Medica, Cikarang, Indonesia; 2National Nuclear Energy Agency, Bandung, Indonesia; 3School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia Abstract: DLBS1033 is a bioactive protein fraction isolated from Lumbricus rubellus that tends to be unstable when exposed to the gastrointestinal environment. Accordingly, appropriate pharmaceutical development is needed to maximize absorption of the protein fraction in the gastrointestinal tract. In vitro, ex vivo, and in vivo stability assays were performed to study the stability of the bioactive protein fraction in gastric conditions. The bioactive protein fraction DLBS1033 was found to be unstable at low pH and in gastric fluid. The “enteric coating” formulation showed no leakage in gastric fluid–like medium and possessed a good release profile in simulated intestinal medium. DLBS1033 was absorbed through the small intestine in an intact protein form, confirmed by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS PAGE analysis. This result confirmed that an enteric coating formula using methacrylic acid copolymer could protect DLBS1033 from the acidic condition of the stomach by preventing the release of DLBS1033 in the stomach, while promoting its release when reaching the intestine. From the blood concentration–versus-time curve, 99mTc-DLBS1033 showed a circulation half-life of 70 minutes. This relatively long biological half-life supports its function as a thrombolytic protein. Thus, an enteric delivery system is considered the best approach for DLBS1033 as an oral thrombolytic agent. Keywords: bioactive protein fraction, enteric coated tablet, pharmacodynamic

  18. Weight Gain, Schizophrenia and Antipsychotics: New Findings from Animal Model and Pharmacogenomic Studies

    OpenAIRE

    Fabio Panariello; Vincenzo De Luca; Andrea de Bartolomeis

    2011-01-01

    Excess body weight is one of the most common physical health problems among patients with schizophrenia that increases the risk for many medical problems, including type 2 diabetes mellitus, coronary heart disease, osteoarthritis, and hypertension, and accounts in part for 20% shorter life expectancy than in general population. Among patients with severe mental illness, obesity can be attributed to an unhealthy lifestyle, personal genetic profile, as well as the effects of psychotropic medica...

  19. Assessment of precipitate formation on interaction of irrigants used in different combinations: An in vitro study

    OpenAIRE

    Amarnath Shenoy; Nagesh Bolla; Sayish; Raj K Sarath; C H Sunil Ram; Sumlatha

    2013-01-01

    Introduction: Irrigants play an essential role in the successful debridement and disinfection of pulp space. Various combination of irrigants used during root canal treatment enhance their efficacy, but some form precipitates which affects the diffusion of intracanal medicaments and the seal of the obturated root canal. Aim: To evaluate the combination of various irrigants whether it forms the precipitate and also to quantify the amount of precipitate formed. Materials and Methods: Fi...

  20. Histomicrobiologic aspects of the root canal system and periapical lesions in dogs' teeth after rotary instrumentation and intracanal dressing with Ca(OH2 pastes Aspectos histomicrobiológicos do sistema de canais radiculares e das lesões periapicais em dentes de cães após instrumentação automatizada e medicação intracanal com pastas de Ca(OH2

    Directory of Open Access Journals (Sweden)

    Janir Alves Soares

    2006-10-01

    Full Text Available OBJECTIVE: The purpose of this study was to evaluate the distribution of microorganisms in the root canal system (RCS and periapical lesions of dogs' teeth after rotary instrumentation and placement of different calcium hydroxide [Ca(OH2]-based intracanal dressings. MATERIALS AND METHODS: Chronic periapical lesions were experimentally induced in 80 premolar roots of four dogs. Instrumentation was undertaken using the ProFile rotary system and irrigation with 5.25% sodium hypochlorite. The following Ca(OH2-based pastes were applied for 21 days: group 1 - Calen (n=18; group 2 - Calen+CPMC (n=20; group 3 - Ca(OH2 p.a. + anaesthetic solution (n=16 and group 4 - Ca(OH2 p.a.+ 2% chlorhexidine digluconate (n=18. Eight root canals without endodontic treatment constituted the control group. Histological sections were obtained and stained with Brown & Brenn staining technique to evaluate the presence of microorganisms in the main root canal, ramifications of the apical delta and secondary canals, apical cementoplasts, dentinal tubules, areas of cemental resorption and periapical lesions. The results were analyzed statistically by the Mann-Whitney U test (p0.05. The percentage of RCS sites containing microorganisms in groups 1, 2, 3, 4 and control were: 67.6%, 62.5%, 78.2%, 62.0% and 87.6%, respectively. CONCLUSION: In conclusion, the histomicrobiological analysis showed that the rotary instrumentation and the different calcium hydroxide pastes employed did not effectively eliminate the infection from the RCS and periapical lesions. However, several bacteria seen in the histological sections were probably dead or were inactivated by the biomechanical preparation and calcium hydroxide-based intracanal dressing.OBJETIVO: Neste estudo avaliou-se a distribuição dos microrganismos no sistema de canais radiculares (SCR e região periapical (RP de cães após instrumentação automatizada e utilização de pastas à base de hidróxido de cálcio CaO(H2

  1. Restoration of Medical Images with Different Types of Noise; Restauracion de Imagenes Medicas con Diferentes Tipos de Ruido

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez, M. G.; Vidal, V.; Verdu, G.; Mayo, P.; Rodenas, F.

    2013-07-01

    In this paper, a method is proposed to reduce the Gaussian, speckle and impulsive noise. This filter, named PGMFDNL filter combines a nonlinear diffusion and fuzzy peer group. The proposed filter can effectively reduce image noise without any information about the noise present in the image. As a result, the proposed method obtains good performance in different types of noise.

  2. Acta Medica Indonesiana - The Indonesian Journal of Internal Medicine 333 Supraclavicular Lymphnodes: Unusual Manifestation of Metastase Adenocarcinoma Colon

    Directory of Open Access Journals (Sweden)

    Harijono Achmad

    2015-12-01

    Full Text Available We report a patient with supraclavicular lymph node metastasis from an undetectable adenocarcinoma of the transverse colon, who presented with cough and was diagnosed with typhoid fever, bronchitis as well as liver metastasis. There were an abdominal fullness, weight loss, constipation, pencil-like stool with mucous and blood, low-grade fever, bone ache, and tea-color urine. The first colonoscopy revealed lymphocytic ileitis and microscopic findings also showed lymphocytic ileitis. Abdominal USG and CT revealed liver metastasis of unknown origin. Based on the clinical sign and symptoms, we suspected that colorectal carcinoma was the primary site. Then, the second colonoscopy was performed and it revealed a small polyp, which was followed with a biopsy and the result supported a well-differentiated colon adenocarcinoma. Similar result was also revealed by the histopathological evaluation. This is an unusual case of liver and supraclavicular lymph node metastasis arising from a small polyp adenocacinoma of the transverse colon. Key words: liver metastase, colorectal carcinoma, lymph node.

  3. Metodos estadisticos empleados en los articulos originales publicados sobre tabaquismo en cuatro revistas medicas espanõlas (1985-1996

    Directory of Open Access Journals (Sweden)

    García López José Antonio

    2000-01-01

    Full Text Available Fundamento: Siendo el tabaquismo un tema prioritario de investigación y habiéndose incrementado el uso de técnicas estadísticas en las publicaciones biomédicas, se describen las técnicas estadísticas utilizadas y se cuantifica la accesibilidad estadística en los artículos originales sobre tabaquismo publicados en cuatro revistas médicas españolas. Métodos: Estudio descriptivo retrospectivo de los 154 artículos originales sobre tabaquismo publicados en las revistas Atención Primaria, Medicina Clínica (Barcelona, Revista Española de Salud Pública y Revista Clínica Española, en el período de 1985 a 1996. Un único observador codificó las técnicas estadísticas en 14 categorías de acuerdo con la clasificación elaborada por Carré et al (1995 a partir de la clasificación establecida por Emerson y Colditz (1983. Para el estudio de la accesibilidad estadística se estableció como referencia el conocimiento de técnicas bivariables, hasta regresión lineal simple. Resultados: El 81,8% de los originales utilizaron la estadística inferencial. Las categorías estadísticas más frecuentemente utilizadas fueron las "Tablas de contingencia" (37,0%, "Estadística descriptiva" (18,2% y "Tablas de vida y análisis de supervivencia" (9,7%. Un lector familiarizado con técnicas bivariables tuvo acceso estadístico al 96,0% de los originales de Revista Española de Salud Pública, al 86,2% de Atención Primaria, al 66,7% de Medicina Clínica (Barcelona y al 33,3% de Revista Clínica Española. Este mismo lector tuvo acceso al 100% de los originales publicados en el trienio 1985-87 y al 68,1% en el 1994-96. Conclusiones: La utilización de técnicas estadísticas varía en función del tema y diseño de investigación, de la revista y del año de publicación. La disminución de la accesibilidad estadística hace necesario identificar el perfil del lector estándar en nuestro país para adaptar sus conocimientos a las exigencias de la literatura biomédica actual.

  4. Management of the quality in medical applications with sealed sources; Gestion de la calidad en aplicaciones medicas con fuentes selladas

    Energy Technology Data Exchange (ETDEWEB)

    Serrano F, A.K.; Araiza M, E. [CNSNS, Dr. Barragan 779, 03020 Mexico D.F. (Mexico)] e-mail: akserrano@cnsns.gob.mx

    2003-07-01

    In this work a model of Quality management based on the ISO 9001:2000 that it includes the application of some established approaches by the IAEA 50-C/SG-Q standard is proposed, so that the different focuses from both standards are joined and achieved: the client satisfaction and certification of the quality system, and structure behavior, components and systems at secure form with a minimum of accidents. This model incorporates a program of radiological protection that emphasizes the installation of a safety culture, (Author)

  5. Uso de medicações por via subaracnóidea no tratamento da dor crônica

    Directory of Open Access Journals (Sweden)

    Rocha Anita Perpétua Carvalho

    2002-01-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A dor crônica é um desafio para a Medicina atual. Novos métodos e medicamentos têm sido propostos com o intuito de controlar os sintomas álgicos. A via de administração subaracnóidea tem se mostrado como uma alternativa viável e segura, embora necessite continuamente ser objeto de estudo de muitos pesquisadores. O objetivo deste trabalho é fazer uma revisão dos medicamentos disponíveis no arsenal terapêutico já consagrados pelo uso e os que se mostram promissores na atualidade para a prática clínica diária. CONTEÚDO: Nesta revisão são avaliados vários fármacos que apresentam ação analgésica quando utilizada via neuroeixo. Opióides, anestésicos locais, agonistas alfa2-adrenérgicos, antagonistas dos aminoácidos excitatórios e inibitórios, acetilcolina, inibidores da acetilcolinesterase, bloqueadores dos canais de cálcio, adenosina, serotonina, antidepressivos tricíclicos e inibidores da síntese de prostaglandinas são analisados no que concerne aos seus efeitos farmacológicos, incluindo os indesejáveis. CONCLUSÕES: Muitos avanços foram registrados no controle dos sintomas álgicos após a utilização das substâncias citadas por via raquidiana, onde certamente algumas serão aproveitadas e enriquecerão o arsenal terapêutico e outras relegadas temporária ou definitivamente. Entretanto, ainda serão necessários muitos estudos clínicos e experimentais para que estes conhecimentos possam ser incorporados e utilizados com segurança pelos profissionais que lidam com o tratamento da dor crônica.

  6. Academic education and training in Medical Physics in Argentina; Formacion academica y entrenamiento en Fisica Medica en la Republica Argentina

    Energy Technology Data Exchange (ETDEWEB)

    Mairal, L., E-mail: lmairal@mevaterapia.com.ar, E-mail: lmairal@gmail.com [Mevaterapia Centro Medico S.A., Buenos Aires (Argentina); Universidad Nacional de La Plata, Buenos Aires (Argentina); Ruggeri, R. [Mevaterapia Centro Medico S.A., Buenos Aires (Argentina); Sansogne, R.; Salinas, F., E-mail: rosana.sansogne@rtp.com.ar [Vidt Centro Medico, Buenos Aires (Argentina); Brunetto, M., E-mail: monica.brunetto@dfunes.com.ar [Centro Medico Dean Funes, Cordoba (Argentina); Valda, A., E-mail: valda@tandar.cnea.gov.ar [Universidad Nacional de San Martin, Buenos Aires (Argentina); Sanz, D., E-mail: dsanz@fuesmen.edu.ar [Fundacion Escuela Medicina Nuclear (FUESMEN), Mendoza (Argentina); Velez, G., E-mail: grvelez@gmail.com [Hospital Oncologico, Cordoba (Argentina); Stefanic, A., E-mail: stefanic@cae.cnea.gov.ar [Comision Nacional de Energia Atomica (CNEA), Buenos Aires (Argentina); Bourel, V., E-mail: vbourel@me.com [Universidad Favaloro, Buenos Aires (Argentina)

    2013-07-01

    This work describes the current offer for academic and clinical training in medical physics in Argentina; as well as the specific requirements for professional licensing in some specializations, known as individual national license. Reference is made to current local legislation, highlighting the fact that diagnostic radiology does not include the requirement of medical physicist’s compulsory advice. Thus, the labor supply is negligible in this area, to the detriment of the quality of this practice, mainly in terms of radiation protection for patients. Additionally, it is important to highlight the absence of the legal definition of a medical physicist as a health professional in the structure of Health Ministries, which increases disadvantages to those who practice this discipline in public health institutions. Finally, it is noted the absence of doctoral programs in medical physics and its impact on research, development and teaching. (author)

  7. Twenty Years of Society of Medical Informatics of B&H and the Journal Acta Informatica Medica

    OpenAIRE

    Masic, Izet

    2012-01-01

    In 2012, Health/Medical informatics profession celebrates five jubilees in Bosnia and Herzegovina: a) Thirty five years from the introduction of the first automatic manipulation of data; b) Twenty five years from establishing Society for Medical Informatics BiH; c) Twenty years from establishing scientific and professional journal of the Society for Medical Informatics of Bosnia and Herzegovina „Acta Informatica Medica“; d) Twenty years from establishing first Cathdra for Medical Informatics ...

  8. Implementation of statistical analysis methods for medical physics data; Implementacao de metodos de analise estatistica para dados de fisica medica

    Energy Technology Data Exchange (ETDEWEB)

    Teixeira, Marilia S.; Pinto, Nivia G.P.; Barroso, Regina C.; Oliveira, Luis F., E-mail: mariliasilvat@gmail.co, E-mail: lfolive@oi.com.b, E-mail: cely_barroso@hotmail.co, E-mail: nitatag@gmail.co [Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ (Brazil). Inst. de Fisica

    2009-07-01

    The objective of biomedical research with different radiation natures is to contribute for the understanding of the basic physics and biochemistry of the biological systems, the disease diagnostic and the development of the therapeutic techniques. The main benefits are: the cure of tumors through the therapy, the anticipated detection of diseases through the diagnostic, the using as prophylactic mean for blood transfusion, etc. Therefore, for the better understanding of the biological interactions occurring after exposure to radiation, it is necessary for the optimization of therapeutic procedures and strategies for reduction of radioinduced effects. The group pf applied physics of the Physics Institute of UERJ have been working in the characterization of biological samples (human tissues, teeth, saliva, soil, plants, sediments, air, water, organic matrixes, ceramics, fossil material, among others) using X-rays diffraction and X-ray fluorescence. The application of these techniques for measurement, analysis and interpretation of the biological tissues characteristics are experimenting considerable interest in the Medical and Environmental Physics. All quantitative data analysis must be initiated with descriptive statistic calculation (means and standard deviations) in order to obtain a previous notion on what the analysis will reveal. It is well known que o high values of standard deviation found in experimental measurements of biologicals samples can be attributed to biological factors, due to the specific characteristics of each individual (age, gender, environment, alimentary habits, etc). This work has the main objective the development of a program for the use of specific statistic methods for the optimization of experimental data an analysis. The specialized programs for this analysis are proprietary, another objective of this work is the implementation of a code which is free and can be shared by the other research groups. As the program developed since the method modeling through his implementation, this fact will allows that modifications and adaptations be accomplished any time at null cost

  9. Uso de medicações por via subaracnóidea no tratamento da dor crônica

    OpenAIRE

    Rocha Anita Perpétua Carvalho; Lemonica Lino; Barros Guilherme Antônio Moreira de

    2002-01-01

    JUSTIFICATIVA E OBJETIVOS: A dor crônica é um desafio para a Medicina atual. Novos métodos e medicamentos têm sido propostos com o intuito de controlar os sintomas álgicos. A via de administração subaracnóidea tem se mostrado como uma alternativa viável e segura, embora necessite continuamente ser objeto de estudo de muitos pesquisadores. O objetivo deste trabalho é fazer uma revisão dos medicamentos disponíveis no arsenal terapêutico já consagrados pelo uso e os que se mostram promissores na...

  10. Medicament control of Xanthium italicum Moretti%意大利苍耳的药剂防除

    Institute of Scientific and Technical Information of China (English)

    车晋滇; 胡彬

    2007-01-01

    意大利苍耳(Xanthium italicum Moretti.)为外来入侵有害杂草,近年来扩展迅速,对农林业生产具有潜在危害性.用72%2,4-滴丁酯乳油50 ml/667m2、25%灭草松水剂400 ml/667m2、20%使它隆乳油60 ml/667m2,在意大利苍耳4~5叶期进行茎叶处理,具有良好的防除效果.

  11. [Contention on the theory of processing techniques of Chinese materia medica in the Ming-Qing period].

    Science.gov (United States)

    Chen, Bin; Jia, Tianzhu

    2015-03-01

    On the basis of the golden stage of development of processing techniques of medicinals in the Song dynasty, the theory and techniques of processing in the Ming-Qing dynasties developed and accomplished further. The knowledge of some physicians on the processing of common medicinal, such as Radix rehmannia and Radixophiopogonis, was questioned, with new idea of processing methods put forward and argued against those insisting traditional ones, marking the progress of the art of processing. By reviewing the contention of technical theory of medicinal processing in the Ming-Qing period, useful references can be provided for the inheritance and development of the traditional art of processing medicinals. PMID:26420409

  12. Metodos estadisticos empleados en los articulos originales publicados sobre tabaquismo en cuatro revistas medicas espanõlas (1985-1996)

    OpenAIRE

    García López José Antonio

    2000-01-01

    Fundamento: Siendo el tabaquismo un tema prioritario de investigación y habiéndose incrementado el uso de técnicas estadísticas en las publicaciones biomédicas, se describen las técnicas estadísticas utilizadas y se cuantifica la accesibilidad estadística en los artículos originales sobre tabaquismo publicados en cuatro revistas médicas españolas. Métodos: Estudio descriptivo retrospectivo de los 154 artículos originales sobre tabaquismo publicados en las revistas Atención Primaria, Medicina ...

  13. Counteraction of reactive oxygen species and determination of antibacterial efficacy of proanthocyanidin and lycopene when mixed with calcium hydroxide and chlorhexidine mixture: An in vitro comparative study

    Directory of Open Access Journals (Sweden)

    T A Mageshwaran

    2012-01-01

    Full Text Available Aim: The objective of the study was to determine the neutralizing effect of proanthocyanidin (grape seed extract and lycopene (tomato extract on reactive oxygen species (ROS generated by the mixture when used as an intracanal medicament. The study also evaluated the effect of proanthocyanidin and lycopene on the antibacterial efficacy of a mixture of chlorhexidine (CHX and calcium hydroxide [Ca(OH 2 ] against Enterococcus feacalis. Materials and Methods: Four sample groups were prepared as follows. Group I: 2% CHX gluconate (control group and group II: a mixture of 125 mg of Ca(OH 2 with 2% CHX gluconate solution. Group III was a mixture of 125 mg of Ca(OH 2 with 1 mL of 2% CHX gluconate solution and 1 mL of 5% proanthocyanidin solution and group IV, a mixture of 125 mg of Ca(OH 2 with 1 mL of 2% CHX gluconate solution and 1 mL of 5% lycopene solution. The groups were analyzed for ROS formation using the mass spectrometer (JEOL GC MATE II immediately after preparation. The antibacterial property was evaluated by using agar diffusion method and the results were statistically analyzed using one-way analysis of variance (ANOVA and Tukey-Kramer multiple comparison tests. Results: The peak value of 196.96 denotes ROS formation. Group II shows a higher peak value than other groups. Group IV shows a drastic reduction in the peak value. Group IV shows a drastic reduction in ROS formation when compared with group II, group III, and the control group. Antibacterial efficacy was higher in group IV, followed by group III, group II, and group I. Conclusion: Lycopene and proanthocyanidin reduce the ROS significantly by virtue of their antioxidant property. Lycopene shows more antioxidant property when compared with proanthocyanidin.

  14. A comparative evaluation of the blood clot, platelet-rich plasma, and platelet-rich fibrin in regeneration of necrotic immature permanent teeth: A clinical study

    Directory of Open Access Journals (Sweden)

    Isha Narang

    2015-01-01

    Full Text Available Introduction: This study was designed as a clinical trial to evaluate and compare the regenerative potential of platelet-rich fibrin (PRF, platelet-rich plasma (PRP, and blood clot in immature necrotic permanent teeth with or without associated apical periodontitis. Methods: Access preparation was done under rubber dam isolation. Copious irrigation was done with 2.5% NaOCl and triple antibiotic paste was placed as an intracanal medicament. After 4 weeks, the cases were divided into four groups with five patients in each group. The study design had three test arms and one control arm. Group I in which mineral trioxide aggregate apexification was carried out and it was kept as control group to evaluate the regenerative potential of blood clot and platelet concentrates, Group II in which blood clot was used as scaffold in the canal, Group III in PRF was used as scaffold, and Group IV in which PRP carried on collagen was used as a scaffold. Results: The clinical and radiographic evaluation after 6 and 18 months was done by two independent observers who were blinded from the groups. The scoring was done as: None score was denoted by, Fair by 1, Good by 2, and Excellent by 3. The data were then analyzed statistically by Fisher′s exact test using Statistics and Data 11.1(PRP Using harvest Smart PReP2 which showed statistically significant values in Group III as compared to other Groups. Conclusion: PRF has huge potential to accelerate the growth characteristics in immature necrotic permanent teeth as compared to PRP and blood clot.

  15. Osservazioni cliniche ed anatomiche nella storia della neuropsicologia del linguaggio: gli studi pre-Broca

    Directory of Open Access Journals (Sweden)

    Claudio Luzzatti

    2013-08-01

    Full Text Available Clinical and Anatomical Observations in the History of Neurolinguistics: Studies Predating Paul Broca – Classical neurological and neuropsychological handbooks usually cite Paul Broca’s communication on the frontal lobes as the seat of articulated speech (1861 as the starting point in the history of the study of aphasia as. In their seminal study, Benton and Joynt (1960 have collected numerous observations of aphasic patients from the Greek, Latin Medieval and Renaissance medical tradition and from the eighteenth-century Enlightenment literature. In none of the reported cases, however, were the crucial elements of aphasia, that is, is, on the one hand the distinction between language deficits, conceptual damage and speech disorders and, on the other hand, the association with lesions of the left brain hemisphere – clearly identified. The first part of this article describes the work of Johannes Schenck and Johannes Jakob Wepfer, two medical scientists in the six-teenth and seventeenth century, whose studies are almost entirely unknown. Johannes Schenck (1530-1598 completed a collection of clinical observations including both reports from antiquity and from his contemporaries. In his first volume (Observationes medicae de capite humano, Basel, 1584 he considers the major diseases of the head and face. At least 16 of these observations refer to patients with aphasia. Johannes Jakob Wepfer (1620-1695 published several texts on neuroanatomy, brain vascularization and apoplexy. He gathered a collection of neurological cases (Observationes medico-practicae de affectibus capitis internis & externis, which was published posthumously. At least 15 of the 222 observations included report the presence of aphasia. As expected, in almost all cases, aphasia was due to lesions in the left hemisphere. Wepfer, however, does not seem to have noted this asymmetry. In the second part of this article, the extraordinary study of Jean-Baptiste Bouillaud (1825

  16. Long-term Angiotensin II AT1 receptor inhibition produces adipose tissue hypotrophy accompanied by increased expression of adiponectin and PPARγ.

    OpenAIRE

    Zorad, Stefan; Jing-tao DOU; Benicky, Julius; Hutanu, Daniel; Tybitanclova, Katarina; Zhou, Jin; Saavedra, Juan M

    2006-01-01

    To clarify the mechanism of the effects of angiotensin II AT1 receptor antagonists on adipose tissue, we treated 8 week-old male Wistar Kyoto rats with the angiotensin II AT1 receptor antagonist Candesartan cilexetil (10 mg/kg/day) for 18 weeks. Candesartan cilexetil reduced body weight gain, decreased fat tissue mass due to hypotrophy of epididymal and retroperitoneal adipose tissue and decreased adipocyte size without changing the number of adipocytes. Candesartan cilexetil decreased serum ...

  17. CLINICAL STUDY ON EFFICACY OF MANDURABHASMA IN MANAGEMENT OF PANDUROGA WITH AND WITHOUT VIRECHANA KARMA

    Directory of Open Access Journals (Sweden)

    Devulapally Anuradha

    2012-06-01

    of Mandurabhasma is far minimal than any other loha bhasmas. Owing to all these additional benefits of Mandurabhasa, it not only proves to be a choice of drug in the treatment of Panduroga but also proves to be a doctor’s and patient’s friendly medicament. 30 patients of Panduroga of different age and sex groups have been selected for the present study. Among which 15 patients were treated by Mandurabhasma alone while the remaining 15 patients were first given virechanakarma followed by Mandurabhasma.

  18. Awareness of Abdominal Adiposity as a Cardiometabolic Risk Factor (The 5A Study: Mexico

    Directory of Open Access Journals (Sweden)

    Garcia-Rubi E

    2011-03-01

    Full Text Available Daniel Cuevas Ramos1, Roopa Mehta1, Julieta De La Luz Castro2, Rutila Castañeda Limones3, Ernesto García Rubí4, Carlos A Aguilar-Salinas11Department of Endocrinology, Instituto Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran" (INCMNSZ; 2Cardiodiabetes Unit, Sanofi-Aventis de México; 3Clinical Epidemiology Research Unit, Hospital General Regional No 1 Dr Carlos Mac Gregor Sánchez Navarro; 4Department of Endocrinology, Hospital Angeles Metropolitano, Mexico City, MexicoBackground: The Awareness of Abdominal Adiposity as a Cardiometabolic Risk Factor Study assesses the prevalence of cardiometabolic risk factors in adults with abdominal obesity (waist circumference ≥90 cm in men and ≥80 cm in women and evaluates how physicians manage these patients.Methods: This is an observational cross-sectional study. Internists, cardiologists, and endocrinologists contributed patients to the study. A standardized questionnaire was completed and registered demographics, anthropometric measurements, lab results from the medical files, and any treatment utilized to manage dyslipidemia, arterial hypertension, diabetes, and cardiovascular disease.Results: A total of 1312 patients was included. The mean age was 49.3 ± 14.6 years and 834 (63.6% were female. The primary reason for the physician consultation was treatment of obesity (47.5%, followed by management of arterial hypertension (27.7%, diabetes (18.3%, dyslipidemia (14.2%, and cardiovascular disease (7.1%. The majority of patients identified excess body weight as a health problem (81.4%. However, patients had lost a mean of 4.3 ± 3.5 kg. Only 63.4% of patients with arterial hypertension were on drug therapy. Few of them had reached target values for diastolic (24.1% and systolic/diastolic (13.3% pressure. Less than half of the patients with dyslipidemia were receiving lipid-lowering medication. Only 32.2% were at their target low-density lipoprotein cholesterol levels. In patients with

  19. Comparison of antimicrobial substantivity of root canal irrigants in instrumented root canals up to 72 h: An in vitro study

    OpenAIRE

    M N Shahani; Subba Reddy, V. V.

    2011-01-01

    Disinfection of the root canal system is one of the primary aims of root canal treatment. This can be achieved through the use of various antimicrobial agents in the form of irrigants and medicaments. The antimicrobial substantivity of 2% chlorhexidine gluconate, 1% povidone iodine, 2.5% hydrogen peroxide followed by 2% sodium hypochlorite, and 2% sodium hypochlorite alone as irrigants was assessed in instrumented root canals. 2% chlorhexidine showed antimicrobial substantivity lasting up to ...

  20. Estudos de utilização de medicamentos: uma síntese de artigos publicados no Brasil e América Latina Drug utilization studies: a synthesis of articles published in Brazil and Latin America

    Directory of Open Access Journals (Sweden)

    Silvana Nair Leite

    2008-04-01

    Full Text Available O medicamento tem se convertido em elemento importante na recuperação e garantia da qualidade de vida; no entanto, há riscos evitáveis associados a seu uso. Neste contexto, o objetivo deste trabalho foi analisar as publicações de estudos de utilização de medicamentos quanto aos tipos de resultados obtidos e suas contribuições para as intervenções terapêuticas. Foram analisados 27 artigos sobre estudos de utilização de medicamentos selecionados nas bases de dados Scielo e Lilacs em relação a objetivos, tipo de estudo, população e amostra selecionada, métodos de estudo e resultados mais relevantes. Os resultados dos artigos analisados foram discutidos a partir das categorias analíticas, criadas através da seleção dos temas emergentes da análise, prevalência do consumo de medicamentos, fatores relacionados ao uso de medicamentos, automedicação, organização dos serviços de saúde, percepção do medicamento e adesão à terapia. De forma geral, as sugestões dos autores restringiram-se à necessidade de prestar informação ao paciente. Conclui-se que as informações construídas pelos estudos de utilização de medicamentos podem ser o caminho inicial para a mudança tão almejada nas práticas profissionais.With the advancements in pharmacotherapy, medicaments turned into important elements and powerful tools in the recovery and maintenance of health and quality of life. However, there are risks associated with their use that can be minimized by investing in drug utilization studies. The objective of this study is to analyze publications in the field of drug utilization with regard to the kinds of results obtained and their contribution to therapeutic interventions. Twenty seven studies on drug utilization selected from the Scielo and Lilacs bases were analyzed as refers to their objectives, kind of study, selected population and sample, methods used and most relevant results. The results of the analyzed papers were

  1. Interaction between the Natural Components in Danhong Injection (DHI) with Serum Albumin (SA) and the Influence of the Coexisting Multi-Components on the SaB-BSA Binding System: Fluorescence and Molecular Docking Studies.

    Science.gov (United States)

    Hao, Jia; Zhang, Yingyue; Wang, Xingrui; Yan, Huo; Liu, Erwei; Gao, Xiumei

    2015-01-01

    Danhong injection (DHI) is a widely used Chinese Materia Medica standardized product for the clinical treatment of ischemic encephalopathy and coronary heart disease. The bindings of eight natural components in DHI between bovine serum albumin (BSA) were studied by fluorescence spectroscopy technology and molecular docking. According to the results, the quenching process of salvianolic acid B and hydroxysafflor yellow A was a static quenching procedure through the analysis of quenching data by the Stern-Volmer equation, the modified Stern-Volmer equation, and the modified Scatchard equation. Meanwhile, syringin (Syr) enhanced the fluorescence of BSA, and the data were analyzed using the Lineweaver-Burk equation. Molecular docking suggested that all of these natural components bind to serum albumin at the site I location. Further competitive experiments of SaB confirmed the result of molecular docking studies duo to the displacement of warfarin by SaB. Base on these studies, we selected SaB as a research target because it presented the strongest binding ability to BSA and investigated the influence of the multi-components coexisting in DHI on the interaction between the components of the SaB-BSA binding system. The participation of these natural components in DHI affected the interaction between the components of the SaB-BSA system. Therefore, when DHI is used in mammals, SaB is released from serum albumin more quickly than it is used alone. This work would provide a new experiment basis for revealing the scientific principle of compatibility for Traditional Chinese Medicine.

  2. Estudo quantitativo da lágrima pelo teste de fenol vermelho na população brasileira Quantitative tear study using the red phenol test in the Brazilian population

    Directory of Open Access Journals (Sweden)

    Richard Yudi Hida

    2005-08-01

    Full Text Available OBJETIVO: Determinar parâmetros normais do teste de fenol vermelho na população brasileira, e comparar entre diferentes raças, idade e sexo. MÉTODOS: Foram avaliados, com o teste de fenol vermelho, 280 indivíduos (560 olhos da raça branca e 280 indivíduos (560 olhos da raça não branca, que foram divididos de acordo com a idade e o sexo. Foram excluídos indivíduos com qualquer doença ocular, usuários de lente de contato e que usavam medicação ocular. RESULTADOS: Dos 1.120 olhos avaliados, o resultado médio foi de 19,77±7,90 mm. CONCLUSÃO: O resultado médio encontrado foi um valor intermediário entre as duas populações previamente estudadas (japonesa e norte-americana.PURPOSE: To detect normal values of red phenol thread test in the Brazilian population and compare it between different races, age and sex. METHODS: 280 white individuals (560 eyes and 280 non-white individuals (560 eyes were analyzed regarding sex and age, and analyzed using the Phenol Red test. Individuals with ocular diseases, contact lens or ocular drug users were excluded from this study. RESULTS: Of the 1,120 evaluated eyes, the mean ± standard deviation result was 19,77±7,90 mm. CONCLUSIONS: The mean result found in this study was an intermediate value compared to the previously studied populations (Japanese and American.

  3. Pharmacokinetic equivalence study of two formulations of the anticonvulsant pregabalin

    Directory of Open Access Journals (Sweden)

    Tjandrawinata RR

    2015-04-01

    Full Text Available Raymond R Tjandrawinata,1 Effi Setiawati,2 Ratih Sofia Ika Putri,2 Vincent Angga Gunawan,2 Fenny Ong,1 Liana W Susanto,1 Dwi Nofiarny11Dexa Laboratories of Biomolecular Sciences, Cikarang, West Java, Indonesia; 2PT Equilab International Bioavailability and Bioequivalence Laboratory, Jakarta, IndonesiaPurpose: The present study was conducted to evaluate whether the bioavailability of pregabalin capsules 150 mg manufactured by PT Dexa Medica was equivalent to the reference formulation.Methods: This was a randomized, open-label, two-period, two-sequence, and crossover study under fasting condition, with a 1-week washout period. Plasma concentrations of pregabalin from 20 subjects were determined by using a validated liquid chromatography with tandem mass spectrometry (LC-MS/MS detection method. Pharmacokinetic parameters assessed in this study were: area under the plasma concentration–time curve from time zero to last observed quantifiable concentration (AUC0–t, area under the plasma concentration–time curve from time zero to infinity (AUC0–∞, maximum plasma concentration (Cmax, time to maximum plasma concentration (tmax, and terminal half-life (t1/2. The 90% confidence intervals (CIs for the geometric mean ratios of test formulation/reference formulation were calculated for the AUC and Cmax parameters; while tmax difference was analyzed nonparametrically on the original data using the Wilcoxon matched-pairs test, and t1/2 difference was analyzed using Student's paired t-test.Results: The mean (standard deviation [SD] AUC0–t, AUC0–∞, Cmax, and t1/2 of pregabalin from the test formulation were 27,845.86 (4,508.27 ng·h/mL, 28,311.70 (4,790.55 ng·h/mL, 3,999.71 (801.52 ng/mL, and 5.66 (1.20 hours, respectively; while the mean (SD AUC0–t, AUC0–∞, Cmax, and t1/2 of pregabalin from the reference formulation were 27,398.12 (4,266.28 ng·h/mL, 27,904.24 (4,507.31 ng·h/mL, 3,849.50 (814.50 ng/mL, and 5.87 (1.25 hours, respectively

  4. O estudo da prova calórica em pacientes idoso The study of caloric testing in senior patients

    Directory of Open Access Journals (Sweden)

    Débora Cristina de Oliveira Bezerra

    2008-01-01

    Full Text Available OBJETIVO: realizar o estudo da prova calórica em pacientes idosos com queixa de tontura, acompanhada ou não de zumbido com finalidade de traçar um perfil dos idosos quanto os sintomas vestibulares. MÉTODOS: fizeram parte da amostra 143 pacientes, com faixa etária variando de 60 a 90 anos de idade; todos realizaram o exame otoneurológico. Foram excluídos pacientes idosos com queixa de desequilíbrio e aqueles que apresentaram a queixa de zumbido desacompanhado da tontura. RESULTADOS: o estudo demonstrou que a normorreflexia, em valores absolutos, encontra-se entre 82,3% a 91,2% e os valores relativos são de 93%. Referente aos dados colhidos na anamnese, o que chamou a atenção, foi que do total de pacientes analisados, encontrou-se a tontura acompanhada de zumbido em 69% dos casos e o elevado uso de medicação em pacientes nesta faixa etária. CONCLUSÃO: na população estudada houve um predomínio da tontura acompanhada de zumbido. Em relação à prova calórica, o trabalho demonstrou a alta prevalência de pacientes com valores absolutos e relativos normais.PURPOSE: to accomplish the study of caloric testing in senior patients with dizziness, accompanied or not of with buzzing. METHODS: 143 patients were analyzed with age varying from 60 to 90 years; all of them did an otoneurologic evaluation. Senior patients with unbalance complaints and with buzzing unaccompanied with dizziness were excluded from this study. RESULTS: 82.3% to 91.2% of the patients obtained normoreflexia in absolute values and over 93% obtained normal results in relative values. Referring to the data obtained in the anamnesis, what got attention was 69% of dizziness accompanied with buzzing. And the high medication of the patients in this age group. CONCLUSION: there was a prevalence of dizziness accompanied with buzzing in the studied population. Concerning the caloric testing, the study demonstrated the high prevalence of patients with normal absolute and

  5. Comparative evaluation of antimicrobial activity of hydroalcoholic extract of Aloe vera, garlic, and 5% sodium hypochlorite as root canal irrigants against Enterococcus faecalis: An in vitro study

    OpenAIRE

    Swati Ramesh Karkare; Nivedita Pramod Ahire; Smita Uday Khedkar

    2015-01-01

    Introduction: Enterococcus faecalis are the most resistant and predominant microorganisms recovered from root canals of teeth where previous treatment has failed. Over the past decade, interest in drugs derived from medicinal plants has markedly increased. In dentistry, phytomedicines has been used as an anti-inflammatory, antibiotic, analgesic, sedative, and also as an endodontic irrigant. In endodontics, because of the cytotoxic reactions of most of the commercial intracanal medicaments and...

  6. Diclofenaco intramuscular no tratamento agudo da migrânea: um estudo duplo cego placebo controlado Intramuscular diclofenac in the acute treatment of migraine: a double-blind placebo controlled study

    Directory of Open Access Journals (Sweden)

    Marcelo E. Bigal

    2002-06-01

    Full Text Available O objetivo do presente estudo é avaliar, com mascaramento duplo, o efeito do diclofenaco sobre a dor e sintomas associados em pacientes com crise de migrânea. Sessenta pacientes com migrânea com aura e sessenta pacientes com migrânea sem aura foram randomizados para receber diclofenaco intramuscular, na dose de 75 mg, associado com injeção intravenosa de solução salina, 10 ml, ou para receber solução salina isoladamente. Três parâmetros de avaliação analgésica e uma escala analógica para avaliar os sintomas associados foram usados. Aferimos ainda os percentuais de recorrência e de utilização de medicação de resgate. Pacientes que receberam diclofenaco apresentaram redução na intensidade da dor estatisticamente significativa, 60 minutos após a administração, em dois dos três parâmetros utilizados (migrânea sem aura e nos três parâmetros utilizados (migrânea com aura. Não observamos diferença, comparado com o placebo, na intensidade dos sintomas associados. Houve redução da recorrência e da utilização de medicação de resgate. A despeito de ser uma opção no tratamento das migrâneas em unidades de emergência, o diclofenaco apresenta início de ação lento e nenhum efeito nos sintomas associados.The aim of this study is to assess, in a double blind fashion, the effect of diclofenac on the pain and associated symptoms in patients with acute migraine. 60 patients with migraine with aura and 60 patients with migraine without aura were assigned at random to receiving intramuscular diclofenac, 75 mg associated to intravenous physiological saline, 10 ml, or physiological saline alone. We used 3 parameters of analgesic evaluation and an analogical scale to asses associated symptoms. We also observed the recurrence and rescue medication percentiles. Patients receiving diclofenac showed a statistically significant improvement of pain 60 minutes after the administration in two of the three parameters

  7. Synchronized separation of seven medications representing most commonly prescribed antihypertensive classes by using reversed-phase liquid chromatography: Application for analysis in their combined formulations.

    Science.gov (United States)

    Ebeid, Walid M; Elkady, Ehab F; El-Zaher, Asmaa A; El-Bagary, Ramzia I; Patonay, Gabor

    2014-04-01

    A reversed-phase high-performance liquid chromatography method was developed for the simultaneous determination of the diuretic, hydrochlorothiazide, along with six drugs representing the most commonly prescribed antihypertensive pharmacological classes such as atenolol, a selective β1 blocker, amlodipine besylate, a calcium channel blocker, moexipril hydrochloride, an angiotensin-converting-enzyme inhibitor, valsartan and candesartan cilexetil, which are angiotensin II receptor blockers, and aliskiren hemifumarate, a renin inhibitor, using irbesartan as an internal standard. The chromatographic separation was achieved using acetonitrile/sodium phosphate dibasic buffer (0.02 M, pH 5.5) at a flow rate of 1 mL/min in gradient elution mode at ambient temperature on a stationary phase composed of an Eclipse XDB-C18 (4.6 × 150 mm, 5 μm) column. UV detection was carried out at 220 nm. The method was validated according to ICH guidelines. Linearity, accuracy, and precision were satisfactory over the concentration ranges of 2-40 μg/mL for hydrochlorothiazide and candesartan cilexetil, 20-120, 10-160, 5-40, 20-250, and 5-50 μg/mL for atenolol, valsartan, moexipril hydrochloride, aliskiren hemifumarate, and amlodipine besylate, respectively. The method was successfully applied for the determination of each of the studied drugs in their combined formulations with hydrochlorothiazide. The developed method is suitable for the quality control and routine analysis of the cited drugs in their pharmaceutical dosage forms. PMID:24482404

  8. The inhibitory effect of candesartan on growth and angiogenesis of mice bearing hepatocellular carcinoma xenograft%坎地沙坦对小鼠肝癌移植瘤及新生血管生成的抑制作用

    Institute of Scientific and Technical Information of China (English)

    韩英; 蒋丽媛; 付晓霞; 李华; 井磊; 赵彩霞; 林延鹏

    2013-01-01

    目的 探讨血管紧张素Ⅱ1型受体拮抗剂坎地沙坦对小鼠肝癌移植瘤生长及血管生成的影响.方法 建立肝癌H22细胞小鼠移植瘤模型.将48只小鼠随机分为生理盐水组(0.2ml d1~d8)、低剂量坎地沙坦组(2mg/kg,0.2ml d1~ds)、高剂量坎地沙坦组(20mg/kg,0.2ml d1~d8)和氟尿嘧啶组(25 mg/kg,0.2ml d1~d6),每组12只.第9天处死小鼠取瘤组织,测瘤重,计算抑瘤率;免疫组化法检测移植瘤组织内血管内皮生长因子(VEGF)和CD34表达,测定微血管密度(MVD).另取40只小鼠以相同条件进行平行实验,每组10只,观察小鼠的生存时间.结果 高剂量坎地沙坦组及氟尿嘧啶组的抑瘤率分别为35.3%和50.6%,均高于低剂量坎地沙坦组的20.7%,差异有统计学意义(P<0.05);与生理盐水组相比,低剂量(5.083±1.240)与高剂量坎地沙坦组(4.083±1.165) VEGF分值均显著降低(P<0.05),且高剂量组降低更明显(P<0.05);与生理盐水组相比,低剂量(20.633±2.171)与高剂量(17.150±2.713)坎地沙坦组MVD均显著降低(P<0.01),且高剂量组降低更明显(P<0.05);高剂量坎地沙坦组及氟尿嘧啶组小鼠的生命延长率分别为39.5%和30.6%,均高于低剂量坎地沙坦组的20.4% (P <0.05).结论 坎地沙坦可抑制小鼠肝癌移植瘤的生长,其机制可能与抑制肿瘤新生血管生成有关.

  9. [Clinico-pathological studies on the effects of calcium hydroxide eugenol preparations to the human vital pulp tissues].

    Science.gov (United States)

    Minagawa, M

    1989-05-01

    The present paper reports results of a study to evaluate clinico-pathologically the effects of calcium hydroxide eugenol preparations on exposed pulp tissues in permanent human teeth. The experiments were performed on 80 vital human teeth from patients ranging in age from 12 to 54 years. The experimental teeth were arbitrarily divided into the following 4 groups. Group CRCS: 20 cases treated with CRCS (Hygienic, Akron, Ohio, USA). Group KEZ: 20 cases treated with Dentalis KEZ (Neo Dental Chemical Products, Tokyo, Japan). Group CE: 20 cases treated with calcium hydroxide eugenol (positive control) Group E: 20 cases treated with pure eugenol (negative control). After local anesthesia, the experimental teeth were isolated with rubber dums or cotton rolls. Following preparation of Black's simple class 1 cavities with a diamond instrument mounted high-speed air turbine, the pulp was intentionally exposed by means of a steel bur mounted electric engine. The cavity and exposed pulp surface were cleaned with saline and dried on absorbent material. Then the experimental materials (agents) were applied to exposed pulp surface. The cavity was lined with gutta-percha temporally stopping, and the remainder was filled with silver amalgam. The teeth were clinically observed at various intervals from immediately to 530 days after treatment and then extracted under local anesthesia and prepared for histopathological study. Decalcified sections were stained with hematoxylin and eosin. 1) CLINICAL OBSERVATIONS: During the observation period, symptoms occurred in the following: Group CRCS: 4 (20%) out of 20 cases. Group KEZ: 4 (20%) out of 20 cases. Group CE: 6 (30%) out of 20 cases. Group E: None of 20 cases No spontaneous pain was observed in these groups. 2) Clinical evaluations Group: CRCS: 16 cases (80%) were good, 3 cases (15%) were satisfactory, and 1 cases (5%) were failure. Group KEZ: 16 cases (80%) were good, 1 cases (5%) were satisfactory, and 3 cases (15%) were failure

  10. Relation between change in blood pressure in acute stroke and risk of early adverse events and poor outcome

    DEFF Research Database (Denmark)

    Sandset, Else C; Murray, Gordon D; Bath, Philip M W;

    2012-01-01

    The Scandinavian Candesartan Acute Stroke Trial (SCAST) found no benefits of candesartan in acute stroke. In the present analysis we aim to investigate the effect of change in blood pressure during the first 2 days of stroke on the risk of early adverse events and poor outcome....

  11. A família do portador de sofrimento psíquico e os serviços de saúde mental: estudo de caso - DOI: 10.4025/actascihealthsci.v26i1.1653 Families of psychic sufferers and mental health services: a case study - DOI: 10.4025/actascihealthsci.v26i1.1653

    Directory of Open Access Journals (Sweden)

    Vânia Moreno

    2004-04-01

    Full Text Available Esta investigação, de natureza qualitativa, tipo estudo de caso, teve como objetivo apresentar qual o entendimento do familiar do portador de sofrimento psíquico na procura pelos serviços de saúde mental, em situação de emergência, hospitalização parcial ou em seguimento ambulatorial. Foram entrevistados 12 familiares que relatam que encontram dificuldades no atendimento no pronto-socorro, quando o paciente está em crise, sendo apenas considerada pelo médico a sintomatologia apresentada pelo mesmo e desvalorizados os saberes adquiridos pela convivência da família com o adoecer psíquico.O hospital-dia é concebido como um espaço para receber cuidados, ocupar o tempo e deve ensinar como uma escola. O acompanhamento ambulatorial representa, para a família, a possibilidade de o paciente assumir a responsabilidade sobre o comparecimento nas consultas e sobre o uso correto da medicação.This qualitative research, case study type, aimed at presenting the understanding of psychic sufferers in search for mental health services during emergency situation, partial hospitalization or in ambulatory services. 12 family members were interviewed. They reported difficulties in the attendance in the emergency room when the patient is in crisis, as well as doctors considering merely the present symptomatology and undervaluing their own knowledge of the sickening process. The day-care hospital is conceived as a place to provide care, occupation and should teach as a school. The ambulatory service represents for the family the possibility of the patient being responsible for their attendance to the consultations and for the correct use of the medication.

  12. Enhanced oral absorption of 20(S-protopanaxadiol by self-assembled liquid crystalline nanoparticles containing piperine: in vitro and in vivo studies

    Directory of Open Access Journals (Sweden)

    Jin X

    2013-02-01

    Full Text Available Xin Jin,1,2 Zhen-hai Zhang,1 E Sun,1 Xiao-bin Tan,1 Song-lin Li,3 Xu-dong Cheng,4 Ming You,4 Xiao-bin Jia11Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing, People's Republic of China; 2College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China; 3Department of Pharmaceutical Analysis and Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, People's Republic of China; 4ALG Bioscience Co, Ltd, Suzhou, People's Republic of ChinaBackground: 20(S-protopanaxadiol (PPD, similar to several other anticancer agents, has low oral absorption and is extensively metabolized. These factors limit the use of PPD for treatment of human diseases.Methods: In this study, we used cubic nanoparticles containing piperine to improve the oral bioavailability of PPD and to enhance its absorption and inhibit its metabolism. Cubic nanoparticles loaded with PPD and piperine were prepared by fragmentation of glyceryl monoolein (GMO/poloxamer 407 bulk cubic gel and verified using transmission electron microscopy and differential scanning calorimetry. We evaluated the in vitro release of PPD from these nanoparticles and its absorption across the Caco-2 cell monolayer model, and subsequently, we examined the bioavailability and metabolism of PPD and its nanoparticles in vivo.Results: The in vitro release of PPD from these nanoparticles was less than 5% at 12 hours. PPD-cubosome and PPD-cubosome loaded with piperine (molar ratio PPD/piperine, 1:3 increased the apical to basolateral permeability values of PPD across the Caco-2 cell monolayer from 53% to 64%, respectively. In addition, the results of a pharmacokinetic study in rats showed that the relative bioavailabilities of PPD-cubosome [area under concentration–time curve (AUC0–∞ ] and PPD-cubosome containing piperine (AUC0–∞ compared to that of raw PPD (AUC0–∞ were 166

  13. Training and Assessment of Hysteroscopic Skills

    DEFF Research Database (Denmark)

    Savran, Mona Meral; Sørensen, Stine Maya Dreier; Konge, Lars;

    2016-01-01

    OBJECTIVE: The aim of this systematic review was to identify studies on hysteroscopic training and assessment. DESIGN: PubMed, Excerpta Medica, the Cochrane Library, and Web of Science were searched in January 2015. Manual screening of references and citation tracking were also performed. Studies...

  14. Comparison of antimicrobial substantivity of root canal irrigants in instrumented root canals up to 72 h: An in vitro study

    Directory of Open Access Journals (Sweden)

    M N Shahani

    2011-01-01

    Full Text Available Disinfection of the root canal system is one of the primary aims of root canal treatment. This can be achieved through the use of various antimicrobial agents in the form of irrigants and medicaments. The antimicrobial substantivity of 2% chlorhexidine gluconate, 1% povidone iodine, 2.5% hydrogen peroxide followed by 2% sodium hypochlorite, and 2% sodium hypochlorite alone as irrigants was assessed in instrumented root canals. 2% chlorhexidine showed antimicrobial substantivity lasting up to 72 h, followed by 1% povidone iodine, and 2% sodium hypochlorite. Thus 2% chlorhexidine should be used as a final rinse irrigant in endodontic treatment protocols.

  15. ORGANIZATIONAL AND LEGAL STUDY OF THE CIRCULATION OF THE COMBINED MEDICINES CONTAINING DEXTROPROPOXYPHENE

    Directory of Open Access Journals (Sweden)

    Shapovalov VV

    2016-03-01

    dekstropropoksyfen-containing medicines should be discharged on a single prescription form F-1. To streamline the rules trafficking controlled drugs, which include controlled narcotic, have restrictions on their circulation stages of prescribing and dispensing, which is associated with quantitative content of psychoactive substances. Thus, for controlled medicines containing in its composition dekstropropoksyfen amount set for delivery in one recipe is not more than 0.6 grams of narcotic drug (p. 1.22.2 Order. In order to control the traffic of controlled medicines containing in its composition dekstropropoksyfen, regardless of its quantity and dosage form, all dekstropropoksyfen-containing medicines be subject-quantifiable in health care institutions that adopted Annex 3 of this order. Conclusions. During the organizational and legal studies analyzed the current pharmaceutical legislation-governing circulation of combined dextropropoxyphene-containing medicines. The particularities of the prescription of dextropropoxyphene-containing medicines were shown. On the example of the medicine of "Spazmoleks" showed the change in the regulatory framework of the combined circulation of the medicines and changing availability dextropropoxyphene-containing medicines for forensic and pharmaceutical criteria of "control mode". During the organizational and legal research conducted a retrospective analysis of prescription turnover dextropropoxyphene-containing medicines. According to the analysis revealed that these drugs are sold from pharmacies and structural units by the prescription F-1. Furthermore, according to existing pharmaceutical legislation it is possible to write and dispense recipe of the F-1 in combined dextropropoxyphene medicaments in an amount of more than 0.6 g in the case when packing products contains not more than 50 tablets. It was fixed that today dextropropoxyphene-containing medicines are subject-quantifiable. In the format of organizational and legal studies analyzed

  16. Pilocarpina no tratamento de xerostomia em pacientes submetidos à iodoterapia: estudo piloto Pilocarpine used to treat xerostomia in patients submitted to radioactive iodine therapy: a pilot study

    Directory of Open Access Journals (Sweden)

    Juliana Pereira Almeida

    2010-10-01

    Full Text Available Xerostomia é uma queixa tardia frequente associada à iodoterapia. Terapias para o tratamento desta morbidade podem proporcionar melhora na qualidade de vida dos pacientes com câncer de tireoide submetidos à iodoterapia adjuvante. OBJETIVOS: Relatar a experiência com o uso da pilocarpina no tratamento de xerostomia em pacientes com câncer de tireoide submetidos à iodoterapia adjuvante. MATERIAL E MÉTODOS: Cinco pacientes preencheram os critérios de inclusão e receberam 5mg de pilocarpina, 3 vezes ao dia, por uma semana. Os efeitos colaterais do medicamento e a resposta subjetiva à queixa de xerostomia após o tratamento foram avaliados. DESENHO DO ESTUDO: Trata-se de um estudo prospectivo, não-randomizado. RESULTADOS: Sudorese foi o efeito colateral mais comum com o uso da pilocarpina, seguido por cansaço e dor de cabeça. Dois pacientes relataram alívio da xerostomia com o uso da medicação, mas somente um paciente foi capaz de tolerar os efeitos colaterais. CONCLUSÕES: Pilocarpina parece aliviar os sintomas de xerostomia em pacientes submetidos à iodoterapia, já que o medicamento é capaz de estimular o fluxo salivar. No entanto, os efeitos colaterais observados inviabilizam seu uso por recusa por parte dos pacientes em continuar a terapia por períodos mais longos.Xerostomia complaint is very commonly associated to radioactive iodine therapy. Alternatives to treat this morbidity can offer better quality of life to patients with thyroid cancer submitted to adjuvant iodine therapy. AIM: to report on the experience with pilocarpine on the treatment of xerostomia in thyroid cancer patients submitted to adjuvant radioactive iodine therapy (RIT. MATERIALS AND METHODS: The five patients who met the inclusion criteria received 5mg of pilocarpine, 3 tid for one week. Side effects of the drug and subjective response to xerostomia complaints after treatment were evaluated. DESIGN: it is a prospective, non-randomized study. RESULTS

  17. A COMPARATIVE STUDY OF LOW DOSE INTRAVAGINAL MISOPR OSTOL (PGE 1 WITH INTRACERVICAL DINOPROSTONE (PGE 2 GEL FOR CERVICAL RIPENING AND LABOUR INDUCTION

    Directory of Open Access Journals (Sweden)

    Jenitha

    2013-04-01

    Full Text Available ABSTRACT: OBJECTIVES: (1 To compare the efficacy of low dose PGE 1 with PGE 2 for induction of labour at term. (2 To compare the safety of PGE 1 with PGE 2 in terms of labour and neonatal outcome. METHODOLOGY: It was an open label randomized controlled trial con ducted in the Department of Obstetrics & Gynecology, Mysore Medica l College Hospital. Total 200 patients satisfying the inclusion criteria were included in the study. One hundred of them received PGE 1 (25 μ g repeated 4 th hourly to a maximum of six doses and remaining on e hundred received PGE 2 (0.5 mg gel repeated 6 th hourly to a maximum of three doses. Analysis was done with respect to age, parity, gestational age, indication f or induction, number of doses required, oxytocin requirement, mode of delivery, indication if LSCS done, induction delivery interval, complications and neonatal outcome with respect to 5 minutes APGAR score, meconium stained liquor and NICU admission. RESULTS: Both groups were comparable to age, parity and gestational age. Oxytocin requirement was more for PGE 2 group (63% than PGE 1 group (35%. LSCS rate was 26% for PGE 1 group compared to 23% in PGE 2 group. The major indication for LSCS was fetal distress in 79.6% of PGE 1 group whereas it was failed induction or failure to progress in 60% of PGE 2 group. Incidence of traumatic PPH was 11% in PGE 1 group compared to 6% in PGE 2 group. Incidence of atonic PPH was 3% in PGE 2 group which was 2% in PGE 1 group. Other complications and induction to delivery interval were comparable in both groups. Neonatal outcome in terms of 5 minutes APGAR < 7, N ICU admission rates and meconium staining of liquor were all less with PGE 2 group. CONCLUSION: Dinoprostone appears to be a safer inducing agent in view of fewer complications with respect to labour and neonatal outcome with induction delivery interval almost equ al in both drugs. Misoprostol is efficacious and low cost agent for cervical ripening and labour

  18. Estudo epidemiológico das lesões traumáticas de plexo braquial em adultos Epidemiological study of the traumatic brachial plexus injuries in adults

    Directory of Open Access Journals (Sweden)

    Leandro Pretto Flores

    2006-03-01

    Full Text Available OBJETIVO: Determinar informações epidemiológicas sobre as variáveis relacionadas ao trauma de plexo braquial em adultos. MÉTODO: Foram analisados 35 pacientes, de maneira prospectiva, atendidos consecutivamente no período de um ano. RESULTADOS: A maioria das lesões apresentou localização supraclavicular (62%, sendo 21 lesões por mecanismo de tração (60%, nove por projétil de arma de fogo (25%, três por compressão (8,5% e dois ferimentos cortantes (5,7%. Acidentes motociclísticos responderam por 54% das causas do trauma. A TC-mielografia identificou avulsão radicular em 16 casos (76%. Melhora neurológica parcial espontânea foi observada em 43% dos pacientes. Dor neuropática foi observada em 25 casos (71% sendo que em 16 (64% pôde ser controlada com medicações orais. CONCLUSÃO: Os traumas de plexo braquial são mais freqüentemente associados aos mecanismos de tração, sendo comum identificação de avulsão radicular. Em geral produzem dor no membro afetado e estão associados a lesões em outros órgãos. Na presente série, a incidência calculada para a população de abrangência foi 1,75/100000/ano.OBJECTIVE: This study aims to provide information about epidemiological factors related to traumatic brachial plexus injuries in adults. METHOD: Prospective analysis of 35 consecutive cases, observed in a period of one year. RESULTS: Most of the lesions were supraclavicular (62%. Twenty-one cases occurred due to traction (60%, 9 to gun shot wound (25%, 3 to compression (8.5% and two perforation/laceration (5.7%. Motorcycle accidents were the cause of trauma in 54% of patients. CT myelography demonstrated root avulsion in 16 cases (76%. Parcial spontaneous neurological recovery was observed in 43% of the patients. Neuropathic pain occurred in 25 (71% cases, and the use of some oral intake drugs (as amitriptiline or carbamazepine controlled it in 64% of times. CONCLUSION: Traction is the most frequent mechanism related to

  19. Effect of angiotensin II on proliferation and differentiation of mouse induced pluripotent stem cells into mesodermal progenitor cells

    International Nuclear Information System (INIS)

    Highlights: ► Treatment with angiotensin II enhanced LIF-induced DNA synthesis of mouse iPS cells. ► Angiotensin II may enhance the DNA synthesis via induction of superoxide. ► Treatment with angiotensin II significantly increased JAK/STAT3 phosphorylation. ► Angiotensin II enhanced differentiation into mesodermal progenitor cells. ► Angiotensin II may enhance the differentiation via activation of p38 MAPK. -- Abstract: Previous studies suggest that angiotensin receptor stimulation may enhance not only proliferation but also differentiation of undifferentiated stem/progenitor cells. Therefore, in the present study, we determined the involvement of the angiotensin receptor in the proliferation and differentiation of mouse induced pluripotent stem (iPS) cells. Stimulation with angiotensin II (Ang II) significantly increased DNA synthesis in mouse iPS cells cultured in a medium with leukemia inhibitory factor (LIF). Pretreatment of the cells with either candesartan (a selective Ang II type 1 receptor [AT1R] antagonist) or Tempol (a cell-permeable superoxide scavenger) significantly inhibited Ang II-induced DNA synthesis. Treatment with Ang II significantly increased JAK/STAT3 phosphorylation. Pretreatment with candesartan significantly inhibited Ang II- induced JAK/STAT3 phosphorylation. In contrast, induction of mouse iPS cell differentiation into Flk-1-positive mesodermal progenitor cells was performed in type IV collagen (Col IV)- coated dishes in a differentiation medium without LIF. When Col IV-exposed iPS cells were treated with Ang II for 5 days, the expression of Flk-1 was significantly increased compared with that in the cells treated with the vehicle alone. Pretreatment of the cells with both candesartan and SB203580 (a p38 MAPK inhibitor) significantly inhibited the Ang II- induced increase in Flk-1 expression. Treatment with Ang II enhanced the phosphorylation of p38 MAPK in Col IV- exposed iPS cells. These results suggest that the stimulation of

  20. Forskelle i mandlige og kvindelige medicinstuderendes tilgang til simulation

    DEFF Research Database (Denmark)

    Konge, Lars; Ali, Amir; Sørensen, Morten;

    2011-01-01

    Simulation-based training is gaining ground as a replacement for the "apprenticeship" model of training. For this reason, it is useful to know if men and women have the same prerequisites and assumptions prior to training. The purpose of the study was to investigate whether male and female medica...

  1. Interface of drug use.

    Science.gov (United States)

    Ludescher, N O; Vergilio, R R; Lucio, C C; Santos, J E G

    2012-01-01

    Packaging and labeling play a crucial role awhile protecting medicaments and transmitting a range of crucial information to the users. Taking into account the scarcity of specific studies in this area, it was considered great the need for a comprehensive survey about customers' satisfaction when handling these containers. PMID:22317633

  2. Active compounds in bitter melon might treat diabetes

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ It seems like your mum was right. A study led by YE Yang with the CAS Institute of Meteria Medica in Shanghai, China and David Ernest James at the University of New South Wales in Sydney has shown that eating bitter melons really is good for you.

  3. Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy

    NARCIS (Netherlands)

    E. Aronica; J.A. Gorter; M. Ramkema; S. Redeker; F. Ozbas-Gercer; E.A. van Vliet; G.L. Scheffer; R.J. Scheper; P. van der Valk; J.C. Baayen; D. Troost

    2004-01-01

    Purpose: This study investigated the cellular distribution of different multidrug resistance (MDR)-related proteins such as P-glycoprotein (P-gp), the multidrug resistance-associated proteins (MRP) 1 and 2, and the major vault protein (MVP) in normal and sclerotic hippocampus of patients with medica

  4. Toxicity and repellency of essential oils to Zabrotes subfasciatus (Boheman) (Coleoptera, Chrysomelidae, Bruchinae) in Phaseolus vulgaris L Toxicidade e repelência de óleos essenciais a Zabrotes subfasciatus (Boheman) (Coleoptera, Chrysomelidae, Bruchinae) em grãos de Phaseolus vulgaris L

    OpenAIRE

    Solange Maria de França; José Vargas de Oliveira; Alberto Belo Esteves Filho; Cynara Moura de Oliveira

    2012-01-01

    The effects of tangerine (Phaseolus vulgaris Blanco), lemon (Citrus medica limonum Lush), pear orange (Citrus sinensis L. Osbeck), red copaiba (Copaifera langsdorffii Desf.), rosemary (Baccharis dracunculifolia De Candole), Eucalyptus (Eucalyptus globulus Labillardière and E. citriodora Hook), lemongrass (Cymbopogon citratus Stapf.) and citronella (Cimbopogon nardus Linnaeus) oils at several concentrations on Zabrotes subfasciatus (Boheman) were studied. In toxicity tests, grains of Phaseolus...

  5. Manual. Communication strategies for increasing the environmental awareness dealing with medicaments; Handbuch. Kommunikationsstrategien zur Schaerfung des Umweltbewusstseins im Umgang mit Arzneimitteln

    Energy Technology Data Exchange (ETDEWEB)

    Goetz, Konrad; Benzing, Corinne; Deffner, Jutta; Keil, Florian

    2011-07-01

    In Germany and almost in all industrialized countries, active drugs ingredients are found in almost all waters and occasionally in drinking water. First signs of effects on aquatic organisms are detected. Among the main players in the health care system, this issue largely is unknown. Only on the basis of a sensibilization, strategies can be implemented in order to raise awareness and ultimately to achieve enlightenment and behavioural changes. This includes issues of prescribing, compliance, non-pharmacological disease prevention through to the doctor-patient relationship.

  6. 白花丹的药学研究与临床应用概述%Materia Medica Research and Clinical Application of Plumbago Zeylanica L.

    Institute of Scientific and Technical Information of China (English)

    赵铁建; 方卓

    2006-01-01

    白花丹为多民族药材,民间应用广泛.现代对其的研究主要有以下四方面:1、生药学与成分研究,其主要药用成份为白花丹醌.2、药理学研究.主要集中在以下几方面:毒性实验、抗菌作用、抗炎与致炎作用、抗肝损伤及肝纤维化、抗肿瘤作用及其他作用.3、单方、验方的应用.有报道用于治疗跌打损伤肿痛、皮肤瘙痒症、注射疼痛及炎症、液体外渗、毒蛇咬伤、风湿骨痛、妊娠早期堕胎.4、组方、复方的应用.有报道用于治疗慢性乙型肝炎、晚期鼻咽癌、疮疡及软组织损伤、眼结膜病、骨关节疾病、男性勃起障碍.

  7. Development of Autoatic Medicament Feeding System Used in Oilfield%油田智能加药系统的研制

    Institute of Scientific and Technical Information of China (English)

    齐晶晶; 黄彩霞; 策红军; 刘军伟

    2012-01-01

    针对目前国内外油田加药装置系统无法动态跟踪加药管道流量、成本高、劳动强度大、无法进行多点监控及协调控制,造成水、电及人力的浪费等现状;采用西门子S7-200 PLC自动检测输油/气管流量,根据设定药液的配比浓度,实现自动配药、自动搅拌、按设定的ppm比例采用模糊自适应PID控制技术实现精确加药的自动控制系统,使注入量误差小于0.3L/h;同时基于以太网实现远程控制,提高了油田生产效率及管理水平;目前,该系统已应用于全国多家著名石油企业,反映良好.%In view of the current domestic and foreign oilfield dosing device system to dynamic tracking dosing pipeline flow, high cost, high labor intensity, can not be multi—point monitoring and control. Adopts Siemens S7 —200 PLC automatic detection of oil/gas flow, according to the set liquid concentration, realize automatic dispensing, automatic mixing, by setting the PPM proportional fuzzy adaptive PID control technology to make injection quantity error is less than 0. 3 L/h and to realize precise dosing of the automatic control system based on Ethernet Remote controlt at the same time, improves the production efficiency and the management level of oil field. At present, the system has been applied to several well—known national oil companies, reflecting is good.

  8. Segurança do paciente: análise do preparo de medicação intravenosa em hospital da rede sentinela

    Directory of Open Access Journals (Sweden)

    Flavia Giron Camerini

    2011-01-01

    Full Text Available La investigación tubo como objetivo identificar el tipo y frecuencia de los errores en la preparación de medicamentos intravenosos. Se trata de una investigación observacional transversal, en tres unidades de un hospital. Se observaron 365 dosis de medicamentos por vía intravenosa preparados por 35 técnicos de enfermería. Los datos se recolectaron de enero a febrero de 2008. Se encontraron tasas de errores en todos los sectores, por encima de 70,00%. Los errores se agruparon en las siguientes categorías: cambio de jeringas, desinfección de las ampollas, higiene de la encimera, hora y dosis errada. Las tasas de errores fueron superiores a 50,00% en todos las categorías, excepto en la dosis errada (6,58%. Se concluye que estas tasas pueden afectar la seguridad microbiológica del procedimiento, aumentando la posibilidad de daño si ocurre la contaminación del medicamento. La preparación en el momento equivocado, antes de una hora, se produjo con tenoxicam y dipirona. La estabilidad de los medicamentos pudo haber sido comprometida, al producir cambios en el resultado terapéutico esperado, lo que puede dar lugar a consecuencias indeseables para los pacientes.

  9. Research of Bioavailability of Chinese Materia Medica Preparation%中药制剂生物利用度研究概况

    Institute of Scientific and Technical Information of China (English)

    李艳玲; 王锦玉; 杨德斌; 董美虹; 仝燕

    2013-01-01

    生物利用度是药物安全性及有效性的重要评价指标.通过检索万方、中国知网及OVI等数据库,对国内外近10年来150余篇相关资料进行全面的分析、整理和综述.从药物和生物两方面阐述了生物利用度的影响因素,包括剂型、理化性质、制剂工艺、胃肠道生理环境、给药时间及途径等.基于此从前体药物设计、胃内滞留释药系统、环糊精包合技术、固体分散技术、共研磨技术、纳米技术等制剂技术方面探讨改善中药制剂生物利用度的研究方法,以期为中药的现代化研究提供有意义的参考.%Bioavailability was important evaluation index of safety and effectiveness of drugs. Consult data library such as Wan Fang, CNKI, OVI and so on, comprehensive analyzed and reviewed more than 150 related data recent 10 years from domestic and abroad. Summarized the influencing factors of bioavailability from two aspects of medicine and biology, consist of the form of drugs, physicochemical property, the preparation technology, physiological environment of gastrointestinal, the delivery time and way and so on. Some new research ideas like the pro-drug strategy, the gastro-retentive drug delivery system, cyclodextrin closure technology, solid dispersion technique, co-grinding technology, nano-technology etc. for improving bioavailability of traditional chinese medicine ( TCM ) preparations were discussed in order to provide reference for the research on modernization of TCM preparations.

  10. Therapy with {sup 90}Y microspheres: radiation protection in new medical therapies; Terapia con microesferas de {sup 90}Y: proteccion radiologica en nuevas terapias medicas

    Energy Technology Data Exchange (ETDEWEB)

    Rojo, Ana; Puerta, Nancy, E-mail: arojo@arn.gob.ar [Autoridad Regulatoria Nuclear (ARN), Buenos Aires (Argentina)

    2013-07-01

    Primary liver cancer is one of the most frequent in the world and with a low cure rate. Radioembolization using 90y spheres is a promising treatment of this pathology and involves the percutaneous vascular application of radioisotope-labeled the order of Micron size particles. The advantages of this technique include the permit administered high doses of radiation to small volumes with low relative toxicity, offer the possibility of treating all the liver including microscopic tumors, and finally, the feasibility of combined with other therapies. Radiation protection in new medical therapies requires justification and optimization, as requirements for their implementation. The application of the principle of optimization in the context of the protection of the patient must be the minimum that it can be reasonably reached compatible with the required doses of treatment dose to healthy tissue. With {sup 90}Y microspheres therapy this optimization applies to the activity of 90y which is administered to the patient, and estimation methods are postulated. in this work are analyzed comparatively these methods, described the early physicists, equations and the limitations of each. Finally, it is concluded that the optimal method to be implemented for the evaluation of the activity of {sup 90}Y manage must be based in a voxel dosimetric model specific for each patient, however, the partitional method may be a good alternative if you don't have the tools to apply the method.

  11. The Influence of Dentine on the pH of Calcium Hydroxide, Chlorhexidine Gel, and Experimental Bioactive Glass-Based Root Canal Medicament

    OpenAIRE

    Ceci Nunes Carvalho; Laila Gonzales Freire; Alexandre Pinheiro Lima de Carvalho; Evandro Luiz Siqueira; José Bauer; Giovana Cunha Gritti; Juliana Pereira de Souza; Giulio Gavini

    2015-01-01

    Objectives. To evaluate the influence of dentine on the pH of different medications in standardized simulated canals. Materials and Methods. Forty resin blocks were divided into groups with and without dentine powder, as follows: 2% chlorhexidine gel; 2% chlorhexidine gel associated with calcium hydroxide PA; calcium hydroxide PA delivered in propylene glycol 600; and NPG delivered in distilled water. The dentine powder was obtained from the root dentine of bovine teeth and added to the medic...

  12. Development in technology and medical physics in radiotherapy: special considerations hadron therapy; Evolucion de la tecnica y de la fisica medica en radioterapia: consideraciones especiales sobre hadronterapia

    Energy Technology Data Exchange (ETDEWEB)

    Mazai, A.; Losa, S.; Farias, R.; Cell, J. c.; Perez, J.; Olivera, G.; Galmarini, D.; Prezado, Y.; Faus-Golfe, A.; Sanchez Parcerisa, D.; Carbe, A.; Venencia, D.; Andreo, P.; Fourquet, A.

    2016-08-01

    This work presents some recent advances in technology and medical physics in the field of radiation oncology. If stands out the progress in anatomical and functional imaging, the availability of beams of photons and charged particles with multiples incidences on the patient, the conformal and monitoring device, as well as the software to calculate and to control the treatments. There is a description of concepts such as intensity modulation, image guided and adaptive radiation therapy, transit dosimetry, hadron therapy and the importance of research in radiation biology, including practical examples. It concludes with the need to evaluate the clinical relevance and the economical aspects of all this advances, as well as how to apply them to get personalized treatments in combination with molecular biology and to spread these benefits to large populations. (Author)

  13. Application of a latent variables model for the medical images analysis; Aplicacion de un modelo de variables latentes para el analisis de imagenes medicas

    Energy Technology Data Exchange (ETDEWEB)

    Campos S, Y.; Ruiz C, S. [Centro de Investigacion en Matematica, A.C. Jalisco s/n, Col. Valenciana, Guanajuato (Mexico)

    2008-07-01

    In recent years the technological advance has allowed the significant advance in diverse research fields, the medicine has not been exempt of this technology and the use of this technology has allowed a significant advance in the equipment that are used to obtain medical images. The quantity of information that is generated with this equipment has grown in exponential form and it is a difficult task to carry out a quantitative analysis of the data also the manipulation of big quantities of information makes the medical images analysis a complicated task. It is in fact this complexity what motivates this work where one of the main objectives is the analysis of techniques that allow to work with the complexity of the data generated with medical equipment. Likewise, it is wanted to illustrate an application of the peaceful uses of the nuclear energy to treat a medical problem where the diagnostic it depends essentially on the current medical equipment to give an appropriate treatment to the patients. (Author)

  14. Research progression on Gains of broussonetia papyrifera(L.) vent as Chinese materia medica%中药楮实的研究进展

    Institute of Scientific and Technical Information of China (English)

    姜俊; 郑刚

    2003-01-01

    @@ 楮实又名楮实子、楮桃、角树子……为桑科构树broussonetia papyrifera(L.)vent.的成熟果实,具有补肾、清肝、明目、利尿的功效[1].本文就楮实的本草学记载和现代药理及临床研究等进行了综述.

  15. 根管治疗约诊间疼痛的临床控制%Effect of Different Intracanal Medicaments on the Occurrence of Endodontic Interappointment Pain

    Institute of Scientific and Technical Information of China (English)

    高洁; 徐瑛

    2011-01-01

    目的:通过磨牙根管治疗过程中3种根管内封药方法的疗效比较,探讨根管治疗约诊间疼痛(EIAP)的控制措施.方法:将262例患者274颗患牙据根管预备后根管内封药分为Vitapex糊剂组、氢氧化钙糊剂组以及樟脑酚药尖组,1周后约诊,观察记录患者的疼痛、肿胀情况.结果:根管治疗过程中约诊间疼痛的发生率Vitapex糊剂组较其它2组低,有显著性差异(P<0.05).结论:Vitapex 根管糊剂根管内封药可以有效地控制EIAP的发生.

  16. Medical response in the initial phase of a radiological or nuclear emergency; Respuesta medica en la fase inicial de una emergencia radiologica o nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Vazquez, M.; Perez, M.R.; Dubner, D.; Michelin, S.; Malvicini, M. [Autoridad Regulatoria Nuclear, Av. Del Libertador 8250, Gobierno Autonomo de la Ciudad de Buenos Aires (Argentina)]. e-mail: mvazquez@cae.arn.gov.ar

    2006-07-01

    The frequency of radiological and nuclear accidents is low with relationship to another type of have an accident, but the use of radioactive sources has been increased in the finish decades. Additionally, a growing world concern exists by the eventual use of radioactive material with malevolent ends. These facts put in relevance the necessity to have an appropriate preparation for the medical answer in this type of emergencies. The medical answer consists of different phases: Initial: pre-hospital and in local general hospitals; Intermediate: in local general hospitals and central reference hospitals. Late: in central reference hospitals and the pursuit to long term. The presence of conventional injuries (radio combined injuries) modifies in substantial form the assignment in the priority of the attention, the prediction and the evolution. The establishment of an appropriate triage is outstanding in the initial phase. The present communication approaches the early medical answer, sustained in the anamnesis, the chronology and severity of the symptoms and prodromal signs besides the laboratory results and complementary exams arisen during the first ones 24 to 72 hours. (Author)

  17. Microarray analysis of Etrog citron (Citrus medica L.) reveals changes in chloroplast, cell wall, peroxidase and symporter activities in response to viroid infection.

    Science.gov (United States)

    Rizza, Serena; Conesa, Ana; Juarez, José; Catara, Antonino; Navarro, Luis; Duran-Vila, Nuria; Ancillo, Gema

    2012-10-01

    Viroids are small (246-401 nucleotides), single-stranded, circular RNA molecules that infect several crop plants and can cause diseases of economic importance. Citrus are the hosts in which the largest number of viroids have been identified. Citrus exocortis viroid (CEVd), the causal agent of citrus exocortis disease, induces considerable losses in citrus crops. Changes in the gene expression profile during the early (pre-symptomatic) and late (post-symptomatic) stages of Etrog citron infected with CEVd were investigated using a citrus cDNA microarray. MaSigPro analysis was performed and, on the basis of gene expression profiles as a function of the time after infection, the differentially expressed genes were classified into five clusters. FatiScan analysis revealed significant enrichment of functional categories for each cluster, indicating that viroid infection triggers important changes in chloroplast, cell wall, peroxidase and symporter activities.

  18. New recommendations from the IAEA for medical exposures: impact on nuclear medicine in Brazil; Novas recomendacoes da IAEA para exposicoes medicas: impacto em medicina nuclear no Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Sa, Lidia Vasconcellos de; Kodlulovich, Simone, E-mail: lidia@ird.gov.br, E-mail: simone@cnen.gov.br [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil)

    2013-10-01

    An assessment of the current national standards was performed in order to verify compliance with the new recommendations, taking into account the number of available facilities and medical physicists to meet the requirements. It was found that compliance with the requirements of protocol optimization and individualization of doses, as well as the assignment of responsibility shared by all professionals involved were not disclosed. In Brazil, there is no reference levels established as also there is not a government program to obtain them. The functions and responsibilities of the medical physicist in conducting dosimetry individual patient, quality control and acceptance tests of equipment and also the calibration is not defined in the standard. Currently in Brazil there are 31 certified Medical Physicists in Medicine Nuclear power to meet approximately 390 facilities, representing only 8% required. As a member state of the IAEA, the Brazilian rules governed by CNEN is based on BSS-115, must come to terms with the GSR. The concern is now meeting the requirements, especially those relating to patients, since we have established benchmarks and individualized dosimetry. Beyond addition, the number of medical physicists are not enough to show the country's demand. (author)

  19. 热者寒之细胞中药学初探%Exploring cytological effect of Chinese material medica by treating hot syndrome with cold drugs

    Institute of Scientific and Technical Information of China (English)

    王征; 张宁; 王翠玲; 刘竹兰; 刘建利

    2015-01-01

    Objective To test whether the traditional therapeutic rule“to treat hot syndrome with cold drugs”can ap-ply to the hot syndrome cell model which was established with hot drugs. Methods Five hot herbal drugs white Peper (50 μg / mL),Piper longum L.(50 μg / mL),Alpinia officinarum Hance(100 μg / mL),Evodia rutaecarpa(Juss. ) Benth(10 μg / mL)and Cinnamomum cassia presl.(20 μg / mL)were used to treat the cell to induce hot model. Then three cold herbal drugs Coptis Chinensis Franch,Povygonum cuspidatum sieb,et. Zucc and Cynanchum atratum Bge. 5- 800 μg / mL were used to reverse models. Result Three cold herbal drugs could completely cure the hot syndrome and the results were in accordance with that obtained on animal model. Conclusion The traditional therapeutic rule“to treat hot symptom with cold drug”can apply on cell model.%目的:用热药造热证细胞模型,研究“热者寒之”的基本治则对于细胞来说是否适用。方法分别用白胡椒50μg / mL、荜菝50μg / mL、高良姜100μg / mL、吴茱萸10μg / mL、肉桂20μg / mL 进行造模,再以黄连、虎杖、白薇3味寒药分5~800μg / mL 8个浓度梯度分别进行逆转。结果黄连、虎杖和白薇对5种热药所造模型可以完全逆转,这与动物实验结果一致。结论“热者寒之”这一中医基本治则在细胞水平上是适用的,并将丰富细胞中药学的内容。

  20. Patient safety in a service of medical physics. Key indicators; Seguridad del paciente en un servicio de fisica medica. Indicadores clave

    Energy Technology Data Exchange (ETDEWEB)

    Font Gomez, J. A.; Gandia Martinez, A.; Jimenez Albericio, F. J.; Andres Redondo, M. M.; Mengual Gil, M. A.

    2013-07-01

    The key indicators are those that endure over time to monitor the degree of compliance with the criteria in the processes that are considered key in the service. In the case of our service, define key indicators within the framework of ISO 9001 certification in the process of clinical dosimetry. All problems do not have same casuistry or not, have the same detrimental to the safety of the patient. We have prioritized some of the problems and opportunities for improvement have been found. Standard refers to the value of the indicator that we should or would like to achieve in such a way that if not achieved, action of improvement will be required. (Author)

  1. The Medicament of Prevention and Cure Bee Nosema apis Zander Disease%防治蜜蜂微孢子虫病的药剂

    Institute of Scientific and Technical Information of China (English)

    黄文诚

    2009-01-01

    @@ 北美惟一登记防治蜜蜂微孢子虫病的药剂是烟曲霉素,是从烟曲霉菌(Aspergillus fumigatus)提取制造的一种抗生素.长期以来,证明它成功地应用于防治蜜蜂微孢子虫病,它不杀死微孢子虫孢子,但能巨大减少孢子的产生,降低蜂群中蜜蜂总的感染率.欧盟法规禁止在防治蜂病上使用抗生素,因为病原可能产生抗药性,并且抗生素残留可能存在于蜂产品中.因此,一些研究单位筛选防治微孢子虫病的替代药剂.

  2. Implement on GAP of Chinese Material Medica and Promote the Modernization of Traditional Chinese Medicine%实施中药材GAP推进中药现代化

    Institute of Scientific and Technical Information of China (English)

    徐鸿华

    2001-01-01

    本文综述了中药材GAP的提出和制定过程,阐述了实施中药材GAP是中药现代化、国际化的需要及配套政策和措施,提供了全国实施中药材GAP的简况,并提出了实施GAP的建议.

  3. Medical response for radiological accidents from Regional cooperation : Latin-American radiopathology networks; Cooperacion regional para la respuesta medica en acidentes radiologicos: Red Latinoamericana de Radiopatologia

    Energy Technology Data Exchange (ETDEWEB)

    Valverde, Nelson [Universidade do Estado, Rio de Janeiro, RJ (Brazil). Lab. de Ciencias Radiologicas; Sanhueza, Silvia [Comision Chilena de Energia Nuclear, Santiago (Chile); Cardenas, Juan [Centro de Proteccion y Higiene de las Radiaciones, La Habana (Cuba); Perez, Maria del Rosario; Trano, Jose Luiz Di; Gisone, Pablo [Autoridad Regulatoria Nuclear, Buenos Aires (Argentina). Gerencia de Apoyo Cientifico. Lab. de Radiopatologia

    2001-07-01

    The objective of this program is to have a system, in order to assure an appropriate medical response in the case of radiological accidents and to offer medical advice in aspects related to the biological effects of ionizing radiations in risk assessment of radiation workers, medical exposures, potential effects of prenatal irradiation.

  4. EMITEL e-encyclopaedia of medical physics and dictionary of terms; Enciclopedia eletronica de fisica medica e dicionario de termos - EMITEL

    Energy Technology Data Exchange (ETDEWEB)

    Tabakov, Slavik; Tabakova, Vassilka [King' s College, London (United Kingdom); Smith, Peter [International Organization for Medical Physics (IOMP), York (United Kingdom); Milano, Franco [University of Florence (Italy); Strand, Sven-Erik [University of Lund (Sweden); Lewis, Cornelius [King' s College Hospital (United Kingdom); Stoeva, Magdalena [AM Studio, Plovdiv (Bulgaria)

    2011-07-01

    EMITEL, the e-Encyclopaedia of Medical Physics and its Multilingual Translator (dictionary) have been launched at WC2009 (www.emitel2.eu). This international project attracted more than 300 specialists from 36 countries and grew to be the largest international project in the profession. This paper describes the development of EMITEL, its effective use, and its planned future development. (author)

  5. Contención mecánica y restricción de movimiento en pericias medicas y de ciencias forenses en privados de libertad

    Directory of Open Access Journals (Sweden)

    Juan Diego Rojas Araya

    2003-09-01

    Full Text Available La inclusión del comentario de este reglamento basa su fundamento en la necesidad de que los profesionales médicos y juristas conozcan lo concerniente a toda revisión corporal de personas privadas de libertad, ya que debe respetarse su pudor. Para estos efectos, la revisión de mujeres debe ser realizada por personal femenino. Cuando el detenido asuma una posición hostil o agresiva ante el servidor que procura la revisión corporal, debe recurrirse en primera instancia al dialogo y a la persuasión, y si se utilizará la fuerza, que sea estrictamente la necesaria para poder realizar la diligencia, para lo cual se podrá hacer uso de los instrumentos de seguridad, como la vara policial, el dispositivo de esposas, y cualquier otro autorizado por la Institución.The inclusion of the comments of this manual has its base in the need that professionals in medicine and law acquire the knowledge concerning general check ups of the people who are in jail, because their integrity must be respected. For these effects, women have been checked by female personnel. When the detained person assumes an aggressive or hostile position with the evaluator, the first thing to do is use dialogue and persuasion. Force can be used when it is strictly necessary to carry out the diligence, using security instruments, such as the police stick, handcuffs, and others allowed by the Institution.

  6. Medical Physics in the new undergraduate curriculum of Spanish medical schools; La Fisica Medica en los nuevos planes de estudio de grado de las facultades de medicina espanola

    Energy Technology Data Exchange (ETDEWEB)

    Guibelalde, E.; Calzado, A.; Chevalier, M.

    2011-07-01

    The purpose of this paper is to present a systematic review of the contents of Medical Physics in the curricula of the new curriculum Grade in Spanish medical schools after the entry into force of that legislation.

  7. ISO 9001 certification in the clinical dosimetry process in physics medical service; Certificacion ISO9001 en el proceso de dosimetria clinica en un servicio de fisica medica

    Energy Technology Data Exchange (ETDEWEB)

    Font Gomez, J. A.; Andres Redondo, M. M.; Gandia Martinez, A.; Jimenez Albericio, F. J.; Mengual Gil, M. A.

    2013-07-01

    The objective of this work is to simply name a series of procedures that are part of the certification and technical instructions (manuals about how to perform specific tasks) without going into details. (Author)

  8. [History of the Halle Ars medica Judaica. IV. Development from the middle of the 19th century to the end of the Weimar Republic].

    Science.gov (United States)

    Kaiser, W; Völker, A

    1989-04-15

    The possibilities of an academic career of Jewish physicians were alleviated by the legalities of the second half of the 19th century, however, up to 1918 in many places restrictive statutes in higher education considerably confined a career as professor in ordinary of specialists of Jewish belief. The conditions at Halle university reflect this situation. A complete equalization beginning after 1918 only at some points of scientific concentration led to a recognizable increase of the Jewish-German members in the teaching staff. But already in this phase on the basis of a quickly spreading racial ideology an increasingly appreciable vulgar antisemitism developed. PMID:2662658

  9. Enzymatic hydrolysis of Citrus medica L. var. sarcodactylis(Noot.) swingle%药用佛手柑酶水解条件的研究

    Institute of Scientific and Technical Information of China (English)

    钟秀茵; 黄晓钰

    2005-01-01

    目的:研究纤维素酶水解药用佛手柑的最佳条件.方法:通过正交实验方案测定不同酶解条件佛手柑的酶解率,并比较酶解浆液的营养成分.结果:纤维素酶水解佛手柑的最佳条件为:T=60℃,pH=4.5,S=8.0%,E/S=1.0%,t=1.5 h,此条件下酶解率可达 64.6%.所得的酶解浆液可溶性糖、游离氨基酸总量、黄酮等营养成分均比水浸出液及酸解液高.结论:合适的酶解处理能较好地提高佛手柑的使用价值.

  10. Development of an informative system on aspects of radiological protection in the medical practices; Desarrollo de un sistema informativo sobre aspectos de proteccion radiologica en las practicas medicas

    Energy Technology Data Exchange (ETDEWEB)

    Lopez B, G.M.; Martinez G, A.; Gonzalez R, N.; Hernandez A, R.; Valdes R, M.; Cardenas H, J.; Zaldivar H, W. [CPHR, Calle 20 No. 4113 e/41 y 47, Playa C.P. 11300 La Habana (Cuba); Diaz B, M.; Machado T, A. [Centro Nacional de Seguridad Nuclear, Ciudad de la Habana (Cuba)]. e-mail: gladys@cphr.edu.cu

    2006-07-01

    Today in day is difficult to imagine the development of the medical practices in the diagnosis and treatment of diverse illnesses without the use of the ionizing radiations. In spite of the diffusion and application of these practices, the patients and the public in general don't have full conscience of like the procedures are carried out and the risks that these involve. For it diverse international and national organizations in the last years recommend to include in the programs of radiological protection, all the information that should be given to the patients and the one public that attend as users to the medical institutions to undergo to procedures that imply the use of the ionizing radiations. In Cuba a growing and quick tendency exists to the introduction of nuclear techniques for medical ends, however paradoxically the relative aspects to the communication to the patients and the public in general about the risks of the procedures to that they will be subjected and in consequence on the measures to minimize them is not adequate. Keeping in mind the above-mentioned, specialists of national centers linked to the control and consultant ship in the topics of radiological protection in the medical practices that use ionizing radiations, they worked in the country in the design of an information system that should contribute to elevate the population's culture before the mentioned aspects. The present work describes the structure of this system in function of the different medical attention levels of our national health system. Additionally it exposes the development of a package of varied informative and training tools among those that are folding, posters, guides, instructions, CD Show that its approach general and specific aspects of the uses and risks of medical practices in nuclear medicine, radiodiagnostic and radiotherapy directed so much to health professionals, patients as public in general. (Author)

  11. Prevention of sports injuries. Keys to Optimal Athletic Performance. Romero Rodríguez, Daniel y Tous Fajardo, Julio. Medica Panamericana D. L., Madrid, 2010.

    Directory of Open Access Journals (Sweden)

    Sebastian Pascuas

    2014-12-01

    Full Text Available La obra presenta variados temas, alguno de los cuales son abordados en forma general y en otros los autores profundizan introduciendo al lector en el verdadero  campo de la prevención. Dentro de estos temas dedican un capítulo a uno de los pilares más importantes para  la determinación de puntos débiles, que es la valoración de los aspectos necesarios de la forma física en relación a la posibilidad de lesiones, es decir, poder determinar el perfil lesivo de cada deportista. Se presentan metodologías de tratamiento en la prevención de lesiones basadas en tres pilares fundamentales: enfoque neuromuscular, entrenamiento de la fuerza para orientar los tratamientos y priorizar  el componente excéntrico del movimiento como base funcional para la prevención. Así mismo incorpora una metodología de trabajo por medio de la vibración

  12. Training for the medical response in radiological emergency experiences and results; Capacitacion para la respuesta medica en emergencias radiologicas experiencias y resultados

    Energy Technology Data Exchange (ETDEWEB)

    Cardenas Herrera, J.; Lopez Forteza, Y.

    2003-07-01

    The use of the nuclear techniques in the social practice confers a special imporatnce to the relative aspects to the safety of the practices and radiationsources, for what the implementation of efficient programs of radiation protection constitutes a priority. However in spite of the will before expressed, regrettably radiological situations happen accidental assocaited to multiple causes taht suggest the creation of response capacities to intervention before these fortuitous facts. The experiences accumulated in the last decades related with accidental exposures have evidenced the convenience of having properly qualified human resources for the Medical Response in Radiological Emergencies. The training in the medical aspects of the radiological emergencies acquires a singular character. In such a sense when valuing the national situation put onof manifest deficiences as for the training in medical aspects of the radiological emergencies that advised the development of training programs in such aspects for the different response groups linked to the topic. After identified the training necessities and the scope of the same ones, the contents of the training program were elaborated. The program has as general purpose the invigoration of the capacity of the medical response in front of accidental radiological situations, by means of actions that they bear to prepare groups of medical response in the handling of people accident victims and to the identification of potentials,accidental scenarios, as well as of the necessary resources to confront them. The program content approaches theoretical and paractical aspects to the medical aspect to radiological emergencies. The program include the different topics about fundamental of physical biological to radiation protection, radiation protection during exposure of radiological accidents, medical care for overexposed or contaminated persons, drill, exercises and concludes with designation of a strategy as preparation and response in emergency radilogical. In the country they have been developed an important number of training activities that allowed to quality hundred of specialists. It should be meant that our country has also contributed to the preparation in topics of medical response to Latin American specialists. (Author)

  13. [History of the Halle Ars medica Judaica. IV. Development from the middle of the 19th century to the end of the Weimar Republic].

    Science.gov (United States)

    Kaiser, W; Völker, A

    1989-04-15

    The possibilities of an academic career of Jewish physicians were alleviated by the legalities of the second half of the 19th century, however, up to 1918 in many places restrictive statutes in higher education considerably confined a career as professor in ordinary of specialists of Jewish belief. The conditions at Halle university reflect this situation. A complete equalization beginning after 1918 only at some points of scientific concentration led to a recognizable increase of the Jewish-German members in the teaching staff. But already in this phase on the basis of a quickly spreading racial ideology an increasingly appreciable vulgar antisemitism developed.

  14. Attitudes of Italian general practitioners in the treatment of cancer pain. The Committee of the Associazione Italiana di Oncologia Medica (AIOM).

    Science.gov (United States)

    Minotti, V; Betti, M

    1997-01-01

    The attitude of Italian general practitioners in prescribing practices for patients with cancer pain was assessed by means of a questionnaire. The results indicated that among most of the doctors who completed the questionnaire the basic principles of pain treatment in cancer patients are largely understood. Oral morphine emerged as the most commonly used opioid (60%) and controlled-release morphine as the preferred preparation. Non-steroidal anti-inflammatory drugs were the most commonly used minor analgesics. Fear of side effects and restrictive prescribing regulations emerged as the most important barrier against adequate pain management. The survey emphasised the need for continued efforts in implementing specific educational programming for improvement in cancer pain management.

  15. Relationship between perfectionism and procrastination among medica students%医学生完美主义和拖延行为的关系研究

    Institute of Scientific and Technical Information of China (English)

    赵晋; 叶绮华; 赵静波

    2011-01-01

    Objective To explore the relationship between perfectionism and procrastination among medical students.Methods 327 medical students of two medical universities in Guangzhou were investigated by the chinese Frost Multidimensional Perfectionism Scale and the Aitken Procrastination Inventory.Results Compared with ordinary college students, medical students got higher scores on CM (12.87 ± 5.017 vs 11.5 ± 4.9), PE ( 14.89 ± 4.603 vs 13.6 ± 5.1 ) and Negative Perfectionism (58.08 ± 12.716 vs 56.1 ± 12.4), but got lower scores on PS (18.00±4.679 vs 18.7 ±5.2).There is the significant negative correlation between OR and procrastination (P< 0.001 ).CM, DA, Negative Perfectionism score and procrastination have notable positive correlation (P<0.01 ).The results of regression analysis show that OR and DA can predict procrastination (P<0.01).Conclusions Compared with ordinary college students, the perfectionism among contemporary medical students is higher and high negative perfectionist behaves with more procrastination.%目的 探讨医学生完美主义与拖延行为的关系.方法 用中文Frost完美主义问卷(CFMPS)和Aitken拖延问卷(API)对广州2所医科大学327名在校本科生进行调查.结果 与普通大学生组相比,医学生的"担心错误"因子分[(12.87±5.017)分,(11.5±4.9)分]、"父母期望"因子分[(T4.89±4.603)分,(13.6±5.1)分]、消极完美主义维度得分[(58.08±12.716)分,(56.1±12.4)分]均明显偏高,"个人标准"因子分[(18.00±4.679)分,(18.7±5.2)分]显著低于普通大学生,差异均具有显著性(P<0.01);"条理性"与拖延存在显著负相关(P<0.01),"担心错误"、"行动的疑虑"及消极完美主义维度得分与拖延行为存在显著的正相关(P<0.01);回归分析结果表明,"条理性"和"行动的疑虑"因子对拖延行为有预测作用(P<0.001).结论 当代医学生的完美主义程度比普通大学生高,具有消极完美主义倾向的个体表现出更多的拖延行为.

  16. Analisa Komponen Kimia Minyak Atsiri Kulit Buah Jeruk Cakar Harimau (Citrus Medica L. var. Sarcodactylus) Dengan GC-MS Dan Uji Antioksidan Menggunakan Metode DPPH

    OpenAIRE

    Simanjuntak, Valentine F.

    2014-01-01

    Extraction of essential oils from Peel of Buddha Skin Citrus been done by using stahl. The obtained result was analyzed by GC-MS. The percentage of obtained essential oils was 0,171%. The components of essential oils were Limonene (44,69%), Cyclohexadiene (24,37%), Z-Citral (4,23%), Octadiene (3,29%), α-Pinene (2,75%), β-Pinene (2,56%), Myrcene (2,25%). Then, the obtained essential oils was checked on antioxidant by DPPH method. The value of antioxidant were IC50 = 39,67 μg/ml.

  17. A pilot study of topiramate in children with Lennox-Gastaut syndrome Estudo piloto com topiramato em crianças com síndrome de Lennox-Gastaut

    Directory of Open Access Journals (Sweden)

    MARILISA M. GUERREIRO

    1999-06-01

    Full Text Available We conducted an open, add-on study with topiramate (TPM as adjunctive therapy in Lennox-Gastaut syndrome (LGS, to assess the long-term efficacy and safety and to evaluate quality of life (QL measurements in the chronic use of TPM. We studied 19 patients (11 male; age ranging from 4 to 14 years with uncontrolled seizures receiving 2-3 anti-epileptic drugs. Patients were followed up to 36 months of treatment. A questionnaire was used to query parents about QL. Seven patients completed the study at 36 months and seizure frequency was reduced > 75% in 4, and Realizamos estudo aberto, de adição do topiramato (TPM como medicação adjuvante no tratamento da síndrome de Lennox-Gastaut (SLG, com a finalidade de verificar a eficácia e a segurança de avaliar a qualidade de vida (QV no uso crônico do TPM. Estudamos 19 pacientes (11 do sexo masculino; idade entre 4 e 14 anos com epilepsia de difícil controle e em uso de 2 a 3 drogas anti-epilépticas. Os pacientes foram seguidos por 36 meses. Um questionário foi aplicado aos pais para se avaliar QV. Sete crianças completaram o estudo. A frequência de crises foi reduzida em mais de 75% em 4 e em menos de 50% em 3 delas. Dois pacientes ficaram sem crises. A maioria dos efeitos colaterais relacionou-se ao sistema nervoso central, sendo sonolência e anorexia os mais frequentes e transitórios. Um paciente foi excluído do estudo por apresentar pó na urina. Nenhuma criança necessitou de hospitalização. Aos 36 meses, os pacientes encontravam-se mais alertas (2/7, e houve melhora na interação com o meio ambiente (5/7, na habilidade em realizar tarefas diárias (5/7 e na performance verbal (6/7. Concluímos que o TPM pode ser útil como terapia adjuvante na SLG. A eficácia manteve-se no tratamento a longo prazo em mais de 40% dos pacientes, a segurança foi confirmada e a QV melhorou com o uso do TPM.

  18. Laser-assisted drug delivery in dermatology: from animal models to clinical practice.

    Science.gov (United States)

    Ali, Faisal R; Al-Niaimi, Firas

    2016-02-01

    Topical medicaments are the mainstay of the dermatologists' therapeutic arsenal. Laser-assisted drug delivery enhances the ability of topically applied medicaments to penetrate the skin. We discuss the mechanisms of laser-assisted drug delivery and animal models that have informed clinical practice. We review clinical studies that have employed laser-assisted drug delivery for a range of indications to date including non-melanoma skin cancer, vitiligo, scarring, vaccination, local anaesthesia, analgesia, viral warts, infantile haemangiomas and cosmetic uses. Studies thus far suggest that laser pre-treatment improves transepidermal absorption of topical agents and allows for a much deeper penetration of drugs than is possible with topical medicaments alone. This may allow more efficacious action of current treatments, such that conventional duration of treatment can be shortened or lower concentrations of active agents be used, potentially obviating side effects of treatment. The prospect of using laser technologies to facilitate transdermal vaccination and as an adjunct for inflammatory dermatoses and cosmetic indications remains in its infancy. As larger trials are published, involving greater numbers of patients and utilising various laser and topical medicament parameters, we will enhance our understanding of this nascent modality of treatment delivery. PMID:26694489

  19. Laser-assisted drug delivery in dermatology: from animal models to clinical practice.

    Science.gov (United States)

    Ali, Faisal R; Al-Niaimi, Firas

    2016-02-01

    Topical medicaments are the mainstay of the dermatologists' therapeutic arsenal. Laser-assisted drug delivery enhances the ability of topically applied medicaments to penetrate the skin. We discuss the mechanisms of laser-assisted drug delivery and animal models that have informed clinical practice. We review clinical studies that have employed laser-assisted drug delivery for a range of indications to date including non-melanoma skin cancer, vitiligo, scarring, vaccination, local anaesthesia, analgesia, viral warts, infantile haemangiomas and cosmetic uses. Studies thus far suggest that laser pre-treatment improves transepidermal absorption of topical agents and allows for a much deeper penetration of drugs than is possible with topical medicaments alone. This may allow more efficacious action of current treatments, such that conventional duration of treatment can be shortened or lower concentrations of active agents be used, potentially obviating side effects of treatment. The prospect of using laser technologies to facilitate transdermal vaccination and as an adjunct for inflammatory dermatoses and cosmetic indications remains in its infancy. As larger trials are published, involving greater numbers of patients and utilising various laser and topical medicament parameters, we will enhance our understanding of this nascent modality of treatment delivery.

  20. 禹白附提取物抗HIV病毒的实验研究%Experimental study on anti-HIV activities with extract from tuber of Typhonium giganteum

    Institute of Scientific and Technical Information of China (English)

    温瑞兴; 马洪涛; 王晓艳; 王霞; 杨怡妹; 王小利

    2009-01-01

    Objective To study the effect of anti-HIV-1 virus with extracts from the tuber of Typhonium giganteum.so as to discover new and high efficient anti-HIV-1 leading compounds from natural prod-ucts and Chinese materia medica.Methods Extract from the tuber of T.giganteum was isolated and purifled by the way of phytochemistry,such as column chromatography.Then anti-HIV-1 activities of the extracts were assessed by in vitro method,MT4 cells and HIVⅢB virus were used for the experiment.The results were judged by cytopathic effect(CPE)method and p24 antigen assay method.Mechanism studies were carried out bv BIA techniques(BIACORE~(R)3000 molecule coupled equipment).Results The extracts of T. giganteum showed potential anti-HIV-1 activities.Two of them showed gp-41 transmembrance protein and Vif protein expression inhibition,respectively.Conclusion These extracts in the tuber of T.giganteum might rewardingly contribute to anti-HIV-1 activities,which could be developed to be more efficient and less toxic leading compounds in the further.%目的 研究白附子提取物抗HIV-1的作用,寻找新型高效的抗HIV-1中药先导化合物.方法 采用植物化学技术对禹白附进行提取分离,再通过细胞生物学方法 [细胞病变观察法(CPE)法和MTT法]检验提取物的抗HIV-1作用,并结合作用靶点的研究对提取物的作用机制进行探讨.结果 发现禹白附提取物具有很好的抗HIV-1作用,筛选出3个抗HIV-1作用显著的有效部位,其中两个有效部位的作用靶点分别为HIV-1的gp-41跨膜蛋白和Vif表达蛋白.结论 禹白附提取物具有很强的抗HIV-1作用,为进一步寻找高效低毒的抗HIV-1先导化合物奠定了基础,值得进行深入研究.

  1. Intensidades de treinamento resistido e pressão arterial de idosas hipertensas - um estudo piloto Resistance training intensities and blood pressure of hypertensive older women - a pilot study

    Directory of Open Access Journals (Sweden)

    Eline Silva da Cunha

    2012-12-01

    Full Text Available INTRODUÇÃO: Observa-se que a literatura apresenta uma lacuna acerca da intensidade ideal de treinamento resistido para idosos hipertensos, os poucos estudos existentes utilizam treinamentos com diferentes intensidades. OBJETIVO: Verificar o efeito de duas intensidades de treinamento resistido sobre a pressão arterial de idosas hipertensas controladas. Métodos: Dezesseis idosas hipertensas, controladas por medicação anti-hipertensiva, foram divididas em dois grupos através de sorteio. Nove pacientes foram submetidas a treinamento resistido moderado (G1 e sete, a treinamento resistido leve (G2. As pacientes realizaram oito semanas de treinamento resistido, com frequência de três vezes por semana em dias alternados, no período vespertino. Os exercícios realizados foram respectivamente: leg press, supino reto, extensão de joelhos, puxada frontal, flexão de joelhos, abdução de ombro, abdução unilateral de quadril com cross over e rosca direta com barra. RESULTADOS: As pacientes do G1 apresentaram redução tanto nos valores de repouso da pressão arterial diastólica (PAD p BACKGROUND: The optimum intensity of resistance training for hypertensive elderly has not been studied yet and the few studies in the literature used training with distinct intensities. Objective: To verify the effect of two resistance training intensities on blood pressure (BP of elderly women with controlled hypertension. METHODS: Sixteen older women with hypertension controlled by anti-hypertensive drug were randomly divided into two groups. Nine patients were submitted to moderate resistance training (G1 and seven patients were submitted to mild resistance training (G2. The patients underwent eight weeks of resistance training, with frequency of three times per week on alternate days in the afternoon. The exercises performed were: leg press, bench press, knee extension, lat pull-down, knee flexion, shoulder abduction, standing cable hip abduction and biceps

  2. Associação entre circunferência abdominal e hipertensão arterial em mulheres: Estudo Pró-Saúde Association between abdominal circumference and hypertension among women: the Pró-Saúde Study

    Directory of Open Access Journals (Sweden)

    Maria Helena Hasselmann

    2008-05-01

    Full Text Available O objetivo deste estudo foi estimar a prevalência de hipertensão arterial segundo estratos de circunferência abdominal (CA e índice de massa corporal (IMC, em kg/m² em uma população de funcionárias públicas de universidade localizada no Rio de Janeiro, Brasil. Foram analisados dados seccionais de 1.743 mulheres não grávidas de 24 a 69 anos participantes, em 2001, do Estudo Pró-Saúde. Mulheres com baixo peso ou apresentando IMC > 35kg/m² foram excluídas. Mulheres que apresentavam pressão sangüínea sistólica > 140mmHg ou diastólica > 90mmHg ou faziam uso de medicação anti-hipertensiva foram consideradas hipertensas. A análise foi conduzida segundo dois estratos de CA (normal: 88cm e três de IMC (eutrofia: 18,5-24,9kg/m²; sobrepeso: 25,0-29,9kg/m²; e obesidade I: 30,0-34,9kg/m². Entre mulheres eutróficas, participantes com valores elevados de CA apresentaram o dobro da prevalência de hipertensão arterial do que aquelas com CA This study aimed to estimate the prevalence of hypertension according to levels of abdominal circumference (AC and body mass index (BMI, expressed as kg/m² among public employees at a university in Rio de Janeiro, Brazil. Cross-sectional data were obtained for 1,743 non-pregnant women aged 24-69 years participating in the Pró-Saúde Study. Underweight women and those with BMI > 35kg/m² were excluded. Hypertension was defined as systolic blood pressure >140mmHg or diastolic > 90mmHg or the use of anti-hypertensive drugs. Age-adjusted prevalence rates for hypertension were calculated considering two strata of AC (normal: 88cm and three levels of BMI (normal: 18.5-24.9kg/m²; overweight: 25.0-29.9kg/m²; and obesity I: 30.0-34.9kg/m². Among normal-weight women, participants with high AC showed a two-fold higher prevalence of hypertension as compared to those with AC < 88cm (18% vs. 8%, p < 0.05. Routine measurement of AC, in addition to BMI, could contribute to early identification of

  3. Inhibitors for the hepatitis C virus RNA polymerase explored by SAR with advanced machine learning methods.

    Science.gov (United States)

    Weidlich, Iwona E; Filippov, Igor V; Brown, Jodian; Kaushik-Basu, Neerja; Krishnan, Ramalingam; Nicklaus, Marc C; Thorpe, Ian F

    2013-06-01

    Hepatitis C virus (HCV) is a global health challenge, affecting approximately 200 million people worldwide. In this study we developed SAR models with advanced machine learning classifiers Random Forest and k Nearest Neighbor Simulated Annealing for 679 small molecules with measured inhibition activity for NS5B genotype 1b. The activity was expressed as a binary value (active/inactive), where actives were considered molecules with IC50 ≤0.95 μM. We applied our SAR models to various drug-like databases and identified novel chemical scaffolds for NS5B inhibitors. Subsequent in vitro antiviral assays suggested a new activity for an existing prodrug, Candesartan cilexetil, which is currently used to treat hypertension and heart failure but has not been previously tested for anti-HCV activity. We also identified NS5B inhibitors with two novel non-nucleoside chemical motifs. PMID:23608107

  4. Pulmonary studies

    International Nuclear Information System (INIS)

    Radionuclide studies of the lung are described, as regards perfusion studies, ventilation studies and physiological considerations. The four principal applications for radionuclide studies of the lungs are outlined and the uses of these discussed in relation to particular entities including pulmonary embolic disease, congestive heart failure, asthma, acute, nonasthmatic, bronchial obstruction, chronic pulmonary disease and cancer. (Auth./C.F.)

  5. The Clinical Study on Shoulder Osteoarthritis with Acupotomy Based on “Three Points on Shoulder”%针刀“肩三刀”疗法治疗肩周炎27例临床观察

    Institute of Scientific and Technical Information of China (English)

    李冬; 董晓俊; 徐平

    2015-01-01

    objective clinical observation the effects of therapy for the periarthritis of shoulder pain,joint mobility with acupotomy based on "three points on shoulder",studies the mechanism of the acupotomy,promoting the scope of the clinical application of acupotomy.Methods clinical in 52 patients with periarthritis of shoulder,randomized,control group 25 cases with topical medica-tions,27 patients with acupotomy based on"three points on shoulder"treatment,clinical efficacy of the standard diagnosis of disease and curative effect of TCM to evaluate.results acupotomy therapy can reduce the pain of shoulder joint and improve directions of mo-tion,and the curative effect is superior to the external use medicine control group (P<0.05 ),and working time is fast.conclusion acupotomy therapy in the treatment of periarthritis of shoulder on quick curative effect,and simple,worth clinical promotion.%目的:观察针刀“肩三刀”疗法对肩周炎的疼痛、关节活动度的影响,研究“针刀疗法”的作用机理,拓展”针刀疗法”的临床应用范围。方法:临床入选52例肩周炎患者,随机分为两组,对照组25例采用外用药物治疗,治疗组27例采用针刀“肩三刀”治疗。临床疗效采用“中医病证诊断疗效标准”进行评估。结果:针刀“肩三刀”治疗方法可以改善肩关节的疼痛和肩关节各方向活动度,疗效优于对照组(P<0.05),且起效时间快。结论:针刀“肩三刀”疗法在肩周炎的治疗上疗效确切快捷,且简便易行。

  6. 渗透泵控释片激光打孔的实验研究%Experimental Study of Laser Drilling for the Osmotic Pump Control-Releasing Tablets

    Institute of Scientific and Technical Information of China (English)

    邢子红; 张瑞; 杨彬; 李丽; 蔡伟; 赵媛媛; 张珊

    2011-01-01

    Osmotic pump control-releasing tablet, a new kind of medicament form in pharmaceuticals industry, which improved the curative effect obviously, is favored in the society because of the stationary medicine releasing speed. The dissolution rate of controlled-release tablets is decided by the releasing holes. And laser drilling has the most advantages in the molding method of releasing holes. Based on the research and experiments in a special laser drilling system, the effects of some parameters such as defocusing amount, the laser current, laser pulse width are founded. The defocusing amount had major effect on the coke whole size. The laser current (laser power) mainly affected the carbon layer. And the laser pulse mainly affected the hole depth, etc... These phenomena and rules of the study are reference and guiding significance to improve the efficiency and quality of laser drilling. Meanwhile, they are very important for the development of osmotic pump control-releasing tablet industry.%渗透泵控释片是制药行业的新剂型,因恒定的释药速率对疗效的明显提升而受到青睐.释药孔决定控释片的溶出度,而释药孔的成型方法中激光打孔优势明显.在研制的专用激光打孔设备上进行了释药孔的打孔实验研究,确定了离焦量、激光电流、激光脉宽等参数所起的不同作用.发现离焦量主要影响孔径;激光电流(激光功率)主要影响碳化层;激光脉宽主要影响孔深等.这些现象和规律对提高渗透泵控释片激光打孔的效率和质量具有指导或参考作用,对发展渗透泵控释片产业非常有意义.

  7. Influence of calcium hydroxide on the post-treatment pain in Endodontics: A systematic review

    Directory of Open Access Journals (Sweden)

    K Anjaneyulu

    2014-01-01

    Full Text Available Introduction: Pain of endodontic origin has been a major concern to the patients and the clinicians for many years. Post-operative pain is associated with inflammation in the periradicular tissues caused by irritants egressing from root canal during treatment. It has been suggested that calcium hydroxide intra-canal medicament has pain-preventive properties because of its anti-microbial or tissue altering effects. Some dispute this and reasoned that calcium hydroxide may initiate or increase pain by inducing or increasing inflammation. Objective: To evaluate the effectiveness of calcium hydroxide in reducing the post-treatment pain when used as an intra-canal medicament Materials and Methods: The following databases were searched: PubMed CENTRAL (until July 2013, MEDLINE, and Cochrane Database of Systematic Reviews. Bibliographies of clinical studies and reviews identified in the electronic search were analyzed for studies published outside the electronically searched journals. The primary outcome measure was to evaluate the post-treatment pain reduction when calcium hydroxide is used as an intra-canal medicament in patients undergoing root canal therapy. Results: The reviews found some clinical evidence that calcium hydroxide is not very effective in reducing post-treatment pain when it is used alone, but its effectiveness can be increased when used in combination with other medicaments like chlorhexidine and camphorated monochlorophenol (CMCP. Conclusion: Even though calcium hydroxide is one of the most widely used intra-canal medicament due to its anti-microbial properties, there is no clear evidence of its effect on the post-treatment pain after the chemo-mechanical root canal preparation.

  8. Cystometric study

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/003904.htm Cystometric study To use the sharing features on this page, please enable JavaScript. Cystometric study measures the amount of fluid in the bladder ...

  9. The rationale and design of the antihypertensives and vascular, endothelial, and cognitive function (AVEC trial in elderly hypertensives with early cognitive impairment: Role of the renin angiotensin system inhibition

    Directory of Open Access Journals (Sweden)

    Hart Meaghan

    2009-11-01

    Full Text Available Abstract Background Prior evidence suggests that the renin angiotensin system and antihypertensives that inhibit this system play a role in cognitive, central vascular, and endothelial function. Our objective is to conduct a double-blind randomized controlled clinical trial, the antihypertensives and vascular, endothelial, and cognitive function (AVEC, to compare 1 year treatment of 3 antihypertensives (lisinopril, candesartan, or hydrochlorothiazide in their effect on memory and executive function, cerebral blood flow, and central endothelial function of seniors with hypertension and early objective evidence of executive or memory impairments. Methods/Design The overall experimental design of the AVEC trial is a 3-arm double blind randomized controlled clinical trial. A total of 100 community eligible individuals (60 years or older with hypertension and early cognitive impairment are being recruited from the greater Boston area and randomized to lisinopril, candesartan, or hydrochlorothiazide ("active control" for 12 months. The goal of the intervention is to achieve blood pressure control defined as SBP 20 and without clinical diagnosis of dementia or Alzheimer's disease. Individuals who are currently receiving antihypertensives are eligible to participate if the participants and the primary care providers are willing to taper their antihypertensives. Participants undergo cognitive assessment, measurements of cerebral blood flow using Transcranial Doppler, and central endothelial function by measuring changes in cerebral blood flow in response to changes in end tidal carbon dioxide at baseline (off antihypertensives, 6, and 12 months. Our outcomes are change in cognitive function score (executive and memory, cerebral blood flow, and carbon dioxide cerebral vasoreactivity. Discussion The AVEC trial is the first study to explore impact of antihypertensives in those who are showing early evidence of cognitive difficulties that did not reach the

  10. Environ: E00441 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available E00441 Citrus medica fruit peel Crude drug Citrus medica [TAX:171251] Rutaceae (rue... family) Citrus medica mature fruit peel (dried) Crude drugs [BR:br08305] Dicot plants: rosids Rutaceae (rue family) E00441 Citrus medica fruit peel ...

  11. Case Studies

    International Nuclear Information System (INIS)

    Proven options available to Sri Lanka for large scale electricity generation in the future are coal-fired thermal, oil-fired thermal and Nuclear. Four case studies for groups participated are indicated. Case study for group 1 is comparison of the three options by taking into consideration the capital and recurrent expenditure involved. Environmental effects of the three options are also given. Case study for group 2 is economic comparison of three renewable energy based power generation system. Case study for group 3 is based on energy conservation, efficiency, improvement and demand management. Assuming that a continuous saving of 20 MW of demand from 1996 onwards is effective two projects are suggested to achieve this result. Case study for group 4 is a feasibility study for hydro power development of the Kukule Ganga (river) in Sri Lanka. Participants are required to evaluate one of the three optional development concepts which are technically feasible

  12. Drug: D09196 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ); Ecard LD (TN) Candesartan cilexetil [DR:D00626], Hydrochlorothiazide [DR:D00340] Antihypertensive Therape... individual organs 21 Cardiovascular agents 214 Antihypertensives 2149 Others D09

  13. Studying Zooarchaeology

    Science.gov (United States)

    Moore, Molly; Wolf, Deborah; Butler, Virginia L.

    2012-01-01

    Children often associate the study of bones with dinosaurs or crime scenes. This unit introduces students to "zooarchaeology," the study of animal remains from archaeological sites. Students in grades 3-5 engage in hands-on activities examining bones, shells, and other "hard parts" of animals. They use their observations as a starting point for…

  14. Initial Study

    DEFF Research Database (Denmark)

    Torp, Kristian

    2009-01-01

    Congestion is a major problem in most cities and the problem is growing (Quiroga, 2000) (Faghri & Hamad, 2002). When the congestion level is increased the drivers notice this as delays in the traffic (Taylor, Woolley, & Zito, 2000), i.e., the travel time for the individual driver is simply...... increased. In the initial study presented here, the time it takes to pass an intersection is studied in details. Two major signal-controlled four-way intersections in the center of the city Aalborg are studied in details to estimate the congestion levels in these intersections, based on the time it takes...

  15. Floodplain Study

    Data.gov (United States)

    Montgomery County of Maryland — The purpose of a floodplain study is to establish the 100-year floodplain limits within or near a development in order to preserve the natural resources within the...

  16. Actuarial Studies

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Office of the Actuary in the Centers for Medicare and Medicaid Services (CMS) from time to time conducts studies on various aspects of the Medicare and Medicaid...

  17. Feasibility study

    International Nuclear Information System (INIS)

    The feasibility study itself examines the technical, economic and financial implications of a nuclear power station in depth so as to make sure that nuclear power is the right course to take. This means that it is quite an expensive operation and it is to avoid wasting this money that a pre-feasibility study is carried out. This preliminary study should eliminate cases where the electrical system cannot absorb the capacity of a nuclear station of commercial size, where other sources of power such as hydro-electricity, gas or cheap coal would make nuclear obviously uneconomic or where no suitable sites exist. If this first rather simple survey shows that nuclear power is a credible solution to a utilities need for electricity or heat production plant, then the next stage is a full feasibility study. (orig./TK)

  18. Studying Sideways

    DEFF Research Database (Denmark)

    Plesner, Ursula

    2011-01-01

    inequalities in relation to the people we study. This article argues that not all types of social scientific research interviews benefit from an à priori problematization of power and control, ethics and equality, or emancipation. From a constructivist perspective, the article seeks to displace...... the methodological concern with power related to the ideas of studying up or down and introduce another set of concerns in relation to producing good empirical material when we “study sideways.” The argument is based on analyses of interview situations from a concrete research project, where researcher...... and researched share professional background to some degree, where negotiations replace a researcher-imposed dialogue, and where the circulation of shared or common concepts messes up an orderly division between researchers’ vocabulary and interviewees’ vocabularies. It is proposed that when we study sideways...

  19. Long-term angiotensin II AT1 receptor inhibition produces adipose tissue hypotrophy accompanied by increased expression of adiponectin and PPARgamma.

    Science.gov (United States)

    Zorad, Stefan; Dou, Jing-tao; Benicky, Julius; Hutanu, Daniel; Tybitanclova, Katarina; Zhou, Jin; Saavedra, Juan M

    2006-12-15

    To clarify the mechanism of the effects of angiotensin II AT(1) receptor antagonists on adipose tissue, we treated 8 week-old male Wistar Kyoto rats with the angiotensin II AT(1) receptor antagonist Candesartan cilexetil (10 mg/kg/day) for 18 weeks. Candesartan cilexetil reduced body weight gain, decreased fat tissue mass due to hypotrophy of epididymal and retroperitoneal adipose tissue and decreased adipocyte size without changing the number of adipocytes. Candesartan cilexetil decreased serum leptin levels and epididymal leptin mRNA, increased serum adiponectin levels and epididymal adiponectin mRNA, decreased epididymal tumor necrosis factor alpha (TNFalpha) mRNA, and increased fatty acid synthase mRNA. Considered free of peroxisome proliferator-activated receptor gamma (PPARgamma) agonist activity, Candesartan cilexetil increased epididymal expression of PPARgamma mRNA. The effects of Candesartan cilexetil on adipokine production and release may be attributable to PPARgamma activation and/or decrease in adipocyte cell size. In addition, Candesartan cilexetil treatment increased the expression of epididymal angiotensin II AT(2) receptor mRNA and protein and decreased the expression of renin receptor mRNA. These results suggest that Candesartan cilexetil influences lipid metabolism in adipose tissue by promoting adipose tissue rearrangement and modulating adipokine expression and release. These effects are probably consequences of local angiotensin II AT(1) receptor inhibition, angiotensin II AT(2) receptor stimulation, and perhaps additional angiotensin II-independent mechanisms. Our results indicate that the activity of local renin-angiotensin system plays an important role in adipose tissue metabolism. The decrease in the pro-inflammatory cytokine TNFalpha and the increase in the anti-inflammatory adipokine adiponectin indicate that Candesartan cilexetil may exert significant anti-inflammatory properties. PMID:17064684

  20. Tratamiento del dolor en los estudios de enfermería Management of pain in nursing studies

    Directory of Open Access Journals (Sweden)

    R. M. Sánchez-Sánchez

    2005-03-01

    Full Text Available Introducción: Diversos estudios constatan insuficiente formación del personal de enfermería en el manejo y tratamiento del dolor, siendo este uno de los síntomas más frecuentes a tratar en su ejercicio profesional. Objetivos: Averiguar los conocimientos acerca de la farmacología de los analgésicos y los principios básicos en el tratamiento del dolor entre los estudiantes de enfermería e informar a los docentes para priorizar dichos conocimientos. Diseño: Se realizó una encuesta a los 55 alumnos (53 mujeres y 2 varones de tercer curso de la Escuela de Enfermería de nuestra ciudad. Material y métodos: Las cuestiones se agruparon en dos bloques: Farmacología de analgésicos: identificar los fármacos "narcóticos" de los que no lo son. Conocimientos básicos del tratamiento del dolor: escalera analgésica, indicaciones de la morfina, tolerancia, etc., así como la necesidad del dolor y su actitud ante quien lo padece. Resultados: El 87% de la muestra consideró la cocaína como "narcótico", sobre la dolantina se dispersaron los datos y un alto porcentaje de ellos no supieron encuadrar analgésicos potentes como metamizol o ketorolaco. El nivel de conocimientos básicos en el tratamiento del dolor fue aceptable, aunque debemos tener en cuenta que en un 25% consideraron que el aumento de la dosis de morfina era debido al desarrollo de adicción. Conclusiones: Observamos la necesidad de profundizar más en la farmacología fundamental de los analgésicos, debiendo ser prioritaria en la formación de pregrado, y nos alegra constatar el cambio hacia un mejor conocimiento de los principios básicos del tratamiento del dolor en las nuevas generaciones de Enfermería.Introduction: Diverse studies state insufficient formation of the personnel of Infirmary in the managing and treatment of the pain, being this one of the most frequent symptoms to treating in his professional exercise. Objectives: To verify the knowledges brings over of the

  1. Adesão ao tratamento de manutenção em asma (estudo ADERE Compliance with maintenance treatment of asthma (ADERE study

    Directory of Open Access Journals (Sweden)

    José Miguel Chatkin

    2006-08-01

    Full Text Available OBJETIVO: Avaliar a adesão ao tratamento preventivo de asma persistente moderada e grave. MÉTODOS: Médicos de vários Estados do país foram contactados para selecionar asmáticos persistentes moderados ou graves, maiores de doze anos. Os pacientes receberam salmeterol/fluticasona 50/250 µg diskus durante 90 dias (sendo orientados a retornarem as embalagens ao final do estudo para conferência da dosagem total utilizada. Receberam telefonemas da equipe do estudo no início e ao final de 90 dias para que fosse avaliada a adesão. Foi considerado como aderente ao tratamento o asmático que utilizou no mínimo 85% das doses prescritas. As variáveis estudadas foram sexo, idade, cor, estado civil, escolaridade, tabagismo atual, outras atopias, co-morbidades, gravidade da asma, uso de outras medicações e número de hospitalizações por asma. RESULTADOS: Foram incluídos 131 pacientes oriundos de quinze estados, com taxa geral de adesão de 51,9%. Houve diferença significativa na adesão quanto à gravidade da asma (maior adesão nos casos graves; p = 0,02. Não houve diferença estatisticamente significativa nas demais variáveis. CONCLUSÃO: A taxa geral de adesão ao tratamento de manutenção da asma foi baixa.OBJECTIVE: To determine the rate of compliance with preventive treatment of moderate and severe persistent asthma. METHODS: Physicians at various medical centers across the country were invited to nominate patients for participation in the study. Inclusion criteria were being over the age of 12 and presenting moderate or severe persistent asthma. Participating patients received salmeterol/fluticasone 50/250 µg by dry powder inhaler for 90 days and were instructed to return the empty packages at the end of the study as a means of determining the total quantity used. In order to evaluate compliance, a member of the research team contacted each patient via telephone at the study outset and again at the end of the 90-day study period

  2. Estudos transcriptômicos no contexto da conectividade perturbada em esquizofrenia Transcriptome studies in the context of disturbed connectivity in schizophrenia

    Directory of Open Access Journals (Sweden)

    Andrea Schmitt

    2013-01-01

    Full Text Available Esquizofrenia é uma severa doença neurobiológica com fatores genéticos e ambientais desempenhando um papel na fisiopatologia. Diversas regiões cerebrais têm sido implicadas no processo da doença e estão conectadas em complexos circuitos neuronais. Nos níveis molecular e celular, a conectividade afetada entre essas regiões, envolvendo mielinização disfuncional dos axônios neuronais, bem como as alterações no nível sináptico e metabolismo energético levando a distúrbios na plasticidade sináptica, são os maiores achados em estudos post-mortem. Estudos de microarranjos investigando a expressão gênica contribuíram para os achados de alterações em vias complexas em regiões cerebrais relevantes na esquizofrenia. Além disso, estudos utilizando microdissecção e captura a laser permitiram a investigação da expressão gênica em grupos específicos de neurônios. Entretanto, deve ser mantido em mente que em estudos post-mortem, confusos efeitos de medicação, qualidade de RNAm, bem como capacidade de mecanismos regenerativos neuroplásticos do cérebro em indivíduos com história de vida de esquizofrenia, podem influenciar o complexo padrão de alterações no nível molecular. Apesar dessas limitações, estudos transcriptômicos livres de hipóteses em tecido cerebral de pacientes esquizofrênicos oferecem uma possibilidade única para aprender mais sobre os mecanismos subjacentes, levando a novas ópticas da fisiopatologia da doença.Schizophrenia is a severe neurobiological disease with genetic and environmental factors playing a role in the pathophysiology. Several brain regions have been implicated in the disease process and are connected in complex neuronal circuits. On the cellular and molecular level, affected connectivity between these regions, involving dysfunctional myelination of neuronal axons, as well as alterations on the synaptic level and energy metabolism of neurons leading to disturbances in synaptic

  3. Estudos transcriptômicos no contexto da conectividade perturbada em esquizofrenia Transcriptome studies in the context of disturbed connectivity in schizophrenia

    Directory of Open Access Journals (Sweden)

    Andrea Schmitt

    2012-01-01

    Full Text Available Esquizofrenia é uma severa doença neurobiológica com fatores genéticos e ambientais desempenhando um papel na fisiopatologia. Diversas regiões cerebrais têm sido implicadas no processo da doença e estão conectadas em complexos circuitos neuronais. Nos níveis molecular e celular, a conectividade afetada entre essas regiões, envolvendo mielinização disfuncional dos axônios neuronais, bem como as alterações no nível sináptico e metabolismo energético levando a distúrbios na plasticidade sináptica, são os maiores achados em estudos post-mortem. Estudos de microarranjos investigando a expressão gênica contribuíram para os achados de alterações em vias complexas em regiões cerebrais relevantes na esquizofrenia. Além disso, estudos utilizando microdissecção e captura a laser permitiram a investigação da expressão gênica em grupos específicos de neurônios. Entretanto, deve ser mantido em mente que em estudos post-mortem, confusos efeitos de medicação, qualidade de RNAm, bem como capacidade de mecanismos regenerativos neuroplásticos do cérebro em indivíduos com história de vida de esquizofrenia, podem influenciar o complexo padrão de alterações no nível molecular. Apesar dessas limitações, estudos transcriptômicos livres de hipóteses em tecido cerebral de pacientes esquizofrênicos oferecem uma possibilidade única para aprender mais sobre os mecanismos subjacentes, levando a novas ópticas da fisiopatologia da doença.Schizophrenia is a severe neurobiological disease with genetic and environmental factors playing a role in the pathophysiology. Several brain regions have been implicated in the disease process and are connected in complex neuronal circuits. On the cellular and molecular level, affected connectivity between these regions, involving dysfunctional myelination of neuronal axons, as well as alterations on the synaptic level and energy metabolism of neurons leading to disturbances in synaptic

  4. Ataques de pânico provocados pelo dióxido de carbono: estudo clínico-fenomenológico Carbon dioxide-induced panic attacks: clinical-phenomenologic study

    Directory of Open Access Journals (Sweden)

    Alexandre M Valença

    2001-03-01

    Full Text Available OBJETIVOS: Verificar a sensibilidade de pacientes com transtorno de pânico (TP ao teste de indução de ataques de pânico com dióxido de carbono (CO2 a 35% e analisar a intensidade, a duração e a sintomatologia dos ataques de pânico produzidos por esse agente em laboratório, comparando-os com os ataques de pânico espontâneos nesses pacientes. MÉTODOS: Foram selecionados 31 pacientes com TP com ou sem agorafobia (DSM-IV. Após uma semana sem medicação, os pacientes realizavam duas inalações de capacidade vital: uma de mistura carbogênica (CO2 35% e O2 65% e outra de ar atmosférico comprimido ("placebo", ordenadas ao acaso e separadas por um intervalo de 20 minutos. Essas inalações eram repetidas após duas semanas. Nesse período, os pacientes não recebiam nenhuma medicação psicotrópica. RESULTADOS: Dos pacientes, 22 (71,0% apresentaram ataque de pânico em pelo menos um dos testes com CO2. Os sintomas relatados por eles com maior freqüência foram: dificuldade de respirar (n=20, 91,0%, sensação de sufocação/asfixia (n=18, 81,8%, tontura (n=18, 81,8%, estremecimento (n=14, 63,6%, palpitações (n=13, 59,0% e medo de enlouquecer (n=12, 54,5%. Desse grupo, 11 pacientes (50,0% consideraram os ataques de pânico experimentados no laboratório mais intensos, comparados aos ataques de pânico espontâneos, quatro (18,2% consideraram haver a mesma intensidade entre os dois, e sete (31,8% consideraram o ataque de pânico no laboratório mais leve. CONCLUSÃO: Pacientes com TP têm elevada sensibilidade ao CO2. A inalação de mistura gasosa com 35% de CO2 produz sintomas semelhantes aos ataques de pânico espontâneos, em pacientes com TP. Esse teste pode ser considerado um bom modelo laboratorial para o TP.OBJECTIVES: To verify the sensibility of panic disorder patients to carbon dioxide challenge test and the intensity, duration and symptoms of panic attacks produced by the gas in these patients, comparing these data with

  5. Writing Study and Grammar Study

    Institute of Scientific and Technical Information of China (English)

    马青

    2013-01-01

    This study is undertaken to describe,classify and analyze the problems in Chinese college students’ writing of CET-4 through contrastive analysis,statistical analysis and error analysis.The main problems appearing in CET-4 writing are the wrong usage of words,sentence structures and the lack of coherence.Meanwhile it proves grammar study plays an important and basic role in CET-4 writing.

  6. Security studies

    International Nuclear Information System (INIS)

    Full text: Security studies constitute one of the major tools for evaluating the provisions implemented at facilities to protect and control Nuclear Material against unauthorized removal. Operators use security studies to demonstrate that they are complying with objectives set by the Competent Authority to counter internal or external acts aimed at unauthorized removal of NM. The paper presents the context of security studies carried out in France. The philosophy of these studies is based on a postulated unauthorized removal of NM and the study of the behavior of the systems implemented to control and protect NM in a facility. The potential unauthorized removal of NM usually may take place in two stages. The first stage involves the sequence leading to handling of the NM. It occurs inside the physical barriers of a facility and may include action involving the documents corresponding to Material Control and Accounting systems. At this stage it is possible to limit the risk of unauthorized removal of NM by means of detection capabilities of the MC and A systems. The second stage is more specific to theft and involves removing the NM out of the physical barriers of a facility in which they are being held, notably by affecting the Physical Protection System. Operators have to study, from a quantity and time lapse point of view, the ability of the installed systems to detect unauthorized removal, as well as the possibility of tampering with the systems to mask unlawful operations. Operators have also to analyze the sequences during which NM are accessed, removed from their containment and further removed from the facility in which they are stored. At each stage in the process, the probability of detection and the time taken to carry out the above actions have to be estimated. Of course, these two types of studies complement each other. Security studies have begun, in France, for more than fifteen years. Up to now more than fifty security studies are available in the

  7. Study protocol

    DEFF Research Database (Denmark)

    Thorsteinsson, Troels; Helms, Anne Sofie; Adamsen, Lis;

    2013-01-01

    of first-line cancer therapy. Secondary endpoints are quality of life measured by validated questionnaires and interviews, and physical performance. RESPECT includes a multimodal intervention program, including ambassador-facilitated educational, physical, and social interventions. The educational......Background During cancer treatment children have reduced contact with their social network of friends, and have limited participation in education, sports, and leisure activities. During and following cancer treatment, children describe school related problems, reduced physical fitness......, and problems related to interaction with peers. Methods/design The RESPECT study is a nationwide population-based prospective, controlled, mixed-methods intervention study looking at children aged 6-18 years newly diagnosed with cancer in eastern Denmark (n = 120) and a matched control group in western Denmark...

  8. Treatability studies

    DEFF Research Database (Denmark)

    Bennedsen, Lars Rønn; Studds, Phil

    developed a mobile test unit including equipment for both standard and more advanced oxidation test directly on the site. The remediation techniques included are electrochemical oxidation, photochemical/photocatalytic oxidation, ozone, Fenton’s, permanganate, and persulfate among others. A versatile...... construction of the test unit makes it possible to combine different techniques in order to obtain more aggressive and effective remediation technologies, e.g. UV/ozone or electrochemical/H2O2. Actual case study data is presented to illustrate the benefits of in situ treatability tests prior to full scale......The fundamental information that a well-designed treatability study can provide is essential to the success of all remediation systems. Over the past years several new techniques for in situ and on site remediation of contaminated soil and groundwater have been used with varying degrees of success...

  9. Invisibility Studies

    DEFF Research Database (Denmark)

    Invisibility Studies explores current changes in the relationship between what we consider visible and what invisible in different areas of contemporary culture. Contributions trace how these changes make their marks on various cultural fields and investigate the cultural significance...... of these developments, such as transparency and privacy in urban architecture and the silent invasion of surveillance technologies into everyday life. The book contends that when it comes to the changing relationship of the visible and the invisible, the connection between seeing and not being seen is an exchange...... conditioned by physical and social settings that create certain possibilities for visibility and visuality, yet exclude others. The richness and complexity of this cultural framework means that no single discipline or interdisciplinary approach could capture it single-handedly. Invisibility Studies begins...

  10. Studying Adolescence

    OpenAIRE

    Richter, Linda M.

    2006-01-01

    Young people in their teens constitute the largest age group in the world, in a special stage recognized across the globe as the link in the life cycle between childhood and adulthood. Longitudinal studies in both developed and developing countries and better measurements of adolescent behavior are producing new insights. The physical and psychosocial changes that occur during puberty make manifest generational and early-childhood risks to development, in the form of individual differences in...

  11. Effects of geriatric clinical skills training on the attitudes of medical students.

    OpenAIRE

    Goeldlin, Adrian O; Siegenthaler, Andrea; Moser, André; Stoeckli, Yvette D; Stuck, Andreas E; Schoenenberger, Andreas W

    2014-01-01

    BACKGROUND Physicians' attitudes, knowledge and skills are powerful determinants of quality of care for older patients. Previous studies found that using educational interventions to improve attitude is a difficult task. No previous study sought to determine if a skills-oriented educational intervention improved student attitudes towards elderly patients. METHODS This study evaluated the effect of a geriatric clinical skills training (CST) on attitudes of University of Bern medica...

  12. 苔藓植物DNA条形码的研究进展%The Review on the Study of Bryophytes DNA Barcode

    Institute of Scientific and Technical Information of China (English)

    陈娟; 张安世

    2012-01-01

    will exert more and more important role in the scientific research of bryophytes. [Conclusion] DNA barcode has become the hotspot in biological research in recent years,the technology has extensive application prospect in the fields of life sciences,forensic medicine,epidemiology,medicament and foodstuff quality control ,etc. ,and it will dramatically promote human testing,understand and use biodiversity ability. The study provides reference for the application of DNA barcode in bryophytes research.

  13. Study protocol

    DEFF Research Database (Denmark)

    Madsen, Helle Østergaard; Dam, Ole Henrik; Hageman, Ida

    2012-01-01

    yields a Global Seasonal Score and a prevalence of SAD. Outcomes from the two groups will be compared. Moreover, outcomes from subgroups of the visually impaired population will be compared. ETHICS AND DISSEMINATION: The study is approved by the Danish Data Protection Agency. Results will be published...... in persons with severe visual impairments or blindness and to compare the results to a control group without visual impairments. Moreover, the authors wish to investigate whether SAD is correlated to the degree of impairment or to the diagnosis. METHODS AND ANALYSIS: 2781 persons with visual impairments...

  14. Utilization of stable isotopes in pharmacology and living matter sciences; Emploi des isotopes stables en pharmacologie et dans les sciences de la matiere vivante

    Energy Technology Data Exchange (ETDEWEB)

    Brazier, J.L. [Institut des Sciences Pharmaceutiques et Biologiques, 69 -Lyon (France)

    1994-12-31

    A survey of the various application fields of stable isotopes in the pharmacological and biomedical domains is presented: utilization of labelled molecules as real tracers (metabolism studies with chromatography and mass spectrometry, studies in bio-pharmacy, bio-availability and bio-equivalence for comparison of medicaments forms, use of stable isotope pulsed doses for medicament kinetics study); methods using voluntary induced isotopic effects in a biologic system; utilization of the carbon {sup 13}C/{sup 12}C ratio and its evolution with time in a living system for in vitro, ex vivo, in vivo studies on man and animals: metabolic tests, dysabsorption tests, bacterial proliferation and infection tests, enzymatic induction and inhibition determination tests.

  15. Polirradiculoneuropatia desmielinizante inflamatória crônica: estudo de 18 pacientes Chronic inflammatory demyelinating polyradiculoneuropathy: study of 18 patients

    Directory of Open Access Journals (Sweden)

    Leandro C. Calia

    1997-01-01

    Full Text Available Neste estudo prospectivo, analisamos as características clínicas, evolução e resposta terapêutica de 18 pacientes com a forma idiopática de polirradiculoneuropatia desmielinizante inflamatória crônica, que foram acompanhados por período que variou de 4 a 127 meses. O sexo masculino predominou sobre o feminino (1,25:1 e a idade de início dos sintomas variou de 6 a 85 anos. Observamos a preponderância da forma de evolução progressiva (61,1% sobre a forma recidivante (38,9%, bem como a baixa ocorrência de fatores predisponentes (16,7%. Todos os pacientes apresentavam comprometimento sensitivo e motor, associado a hipo ou arreflexia, enquanto apenas três (16,7% apresentavam comprometimento de nervos cranianos. No exame do liquor, as taxas de proteínas estavam elevadas em 88,9% dos pacientes, com média de 203,4 mg/dl. A eletroneuromiografia mostrou alterações desmielinizantes em todos os pacientes, associadas a alterações axonais em 94,4% deles. Em todos os sete pacientes submetidos a biopsia de nervo sural encontramos alterações compatíveis com desmielinização/remielinização. A análise com imunofluorescência, realizada em três pacientes foi normal em um e evidenciou depósito de anticorpos anti-CD3 em dois e anti-HLA-Dr em um. Optamos pela prednisona como tratamento inicial em todos os pacientes, sendo mantida posteriormente em doses reduzidas e em dias alternados em 72,2% deles. Dois pacientes (11,1% estão assintomáticos mesmo após retirada total da medicação e introduzimos azatioprína, associada ou não ao corticóide, nos quatro pacientes com má resposta à prednisona. Até a última avaliação, 16 pacientes (88,9% evoluíram com melhora funcional.This is a prospective study that describes 18 patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP, idiopathic type. The patients have been followed for a period of 4 to 127 months. We evaluated the clinical characteristics, the evolution

  16. SOCIOLOGICAL STUDIES

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    PAPER Post-Sociology: Exploration and Reflection Xie Lizhong Abstract: "Post-Sociology" refers to a new perspective which is different from tradi- tional perspectives of social studies. "Post-Social History" and "Pluralistic Discourse Analysis" could be seen as its two specific examples. "Discourse Constructivism" and "Pluralism" are the two core concepts of "Post-Sociology". That encouraging people to realize that all "social reality" including our experiences, thoughts and speech are just a "discoursive reality" constructed by social actors under the guidance and constraints of certain discourse system, is the major significance of "PostSociology". Some critics on "Post-Sociology" are misunderstandings, while others couldn't stand to strict analysis.

  17. Conceptual study

    International Nuclear Information System (INIS)

    This appendix is a compendium of topical reports prepared for the Hanford Nuclear Energy Center: Status Report: Conceptual Fuel Cycle Studies for the Hanford Nuclear Energy Center; Selection of Heat Disposal Methods for a Hanford Nuclear Energy Center; Station Service Power Supply for a Hanford Nuclear Energy Center (HNEC); Impact of a Hanford Nuclear Energy Center on Ground Level Fog and Humidity; A Review of Potential Technology for the Seismic Characterization of Nuclear Energy Centers; Reliability of Generation at a Hanford Nuclear Energy Center (HNEC); Meteorological Evaluation of Multiple Reactor Contamination Probabilities for a Hanford Nuclear Energy Center; Electric Power Transmission for a Hanford Nuclear Energy Center (HNEC); The Impact of a Hanford Nuclear Energy Center on Cloudiness and Insolation; and A Licensing Review for an HNEC

  18. Conceptual study

    Energy Technology Data Exchange (ETDEWEB)

    Harty, H.

    1978-09-01

    This appendix is a compendium of topical reports prepared for the Hanford Nuclear Energy Center: Status Report: Conceptual Fuel Cycle Studies for the Hanford Nuclear Energy Center; Selection of Heat Disposal Methods for a Hanford Nuclear Energy Center; Station Service Power Supply for a Hanford Nuclear Energy Center (HNEC); Impact of a Hanford Nuclear Energy Center on Ground Level Fog and Humidity; A Review of Potential Technology for the Seismic Characterization of Nuclear Energy Centers; Reliability of Generation at a Hanford Nuclear Energy Center (HNEC); Meteorological Evaluation of Multiple Reactor Contamination Probabilities for a Hanford Nuclear Energy Center; Electric Power Transmission for a Hanford Nuclear Energy Center (HNEC); The Impact of a Hanford Nuclear Energy Center on Cloudiness and Insolation; and A Licensing Review for an HNEC.

  19. Systems studies

    International Nuclear Information System (INIS)

    The Systems Studies Activity had two objectives: (1) to investigate nontechnical barriers to the deployment of biomass production and supply systems and (2) to enhance and extend existing systems models of bioenergy supply and use. For the first objective, the Activity focused on existing bioenergy markets. Four projects were undertaken: a comparative analysis of bioenergy in Sweden and Austria; a one-day workshop on nontechnical barriers jointly supported by the Production Systems Activity, the development and testing of a framework for analyzing barriers and drivers to bioenergy markets; and surveys of wood pellet users in Sweden, Austria and the U.S.A. For the second objective, two projects were undertaken. First, the Activity worked with the Integrated Bioenergy Systems (IBS) Activity of IEA Bioenergy Task XIII to enhance the BioEnergy Assessment Model (BEAM). This model is documented in the final report of the IBS Activity. The Systems Studies Activity contributed to enhancing the feedstock portion of the model by developing a coherent set of willow, poplar, and switchgrass production modules relevant to both the U.S.A. and the U.K. The Activity also developed a pretreatment module for switchgrass. Second, the Activity sponsored a three-day workshop on modelling bioenergy systems with the objectives of providing an overview of the types of models used to evaluate bioenergy and promoting communication among bioenergy modelers. There were nine guest speakers addressing different types of models used to evaluate different aspects of bioenergy, ranging from techno-economic models based on the ASPEN software to linear programming models to develop feedstock supply curves for the U.S.A. The papers from this workshop have been submitted to Biomass and Bioenergy and are under editorial review 8 refs, 10 tabs

  20. Systems Studies

    Energy Technology Data Exchange (ETDEWEB)

    Graham, R.L.

    1998-03-17

    The Systems Studies Activity had two objectives: (1) to investigate nontechnical barriers to the deployment of biomass production and supply systems and (2) to enhance and extend existing systems models of bioenergy supply and use. For the first objective, the Activity focused on existing bioenergy markets. Four projects were undertaken: a comparative analysis of bioenergy in Sweden and Austria; a one-day workshop on nontechnical barriers jointly supported by the Production Systems Activity; the development and testing of a framework for analyzing barriers and drivers to bioenergy markets; and surveys of wood pellet users in Sweden, Austria and the US. For the second objective, two projects were undertaken. First, the Activity worked with the Integrated BioEnergy Systems (TBS) Activity of TEA Bioenergy Task XIII to enhance the BioEnergy Assessment Model (BEAM). This model is documented in the final report of the IBS Activity. The Systems Studies Activity contributed to enhancing the feedstock portion of the model by developing a coherent set of willow, poplar, and switchgrass production modules relevant to both the US and the UK. The Activity also developed a pretreatment module for switchgrass. Second, the Activity sponsored a three-day workshop on modeling bioenergy systems with the objectives of providing an overview of the types of models used to evaluate bioenergy and promoting communication among bioenergy modelers. There were nine guest speakers addressing different types of models used to evaluate different aspects of bioenergy, ranging from technoeconomic models based on the ASPEN software to linear programming models to develop feedstock supply curves for the US. The papers from this workshop have been submitted to Biomass and Bioenergy and are under editorial review.

  1. Molecular effects of bioactive fraction of Curcuma mangga (DLBS4847) as a downregulator of 5α-reductase activity pathways in prostatic epithelial cells

    OpenAIRE

    TJANDRAWINATA, Raymond; Karsono, Agung Heru; Tandrasasmita,Olivia

    2014-01-01

    Agung Heru Karsono, Olivia Mayasari Tandrasasmita, Raymond R TjandrawinataSection of Molecular Pharmacology, Research Innovation and Invention, Dexa Laboratories of Biomolecular Sciences, Dexa Medica, Cikarang, IndonesiaAbstract: DLBS4847 is a standardized bioactive fraction of Curcuma mangga. In this study, we used prostate cancer (PC)-3 as the cell line to study the effects of DLBS4847 on prostatic cell viability, as well as related molecular changes associated with the decreased cell numbe...

  2. Dyreforsøg - implementering af de 3R'er i den prækliniske forskning

    OpenAIRE

    Al-Sari, Naba; Rasool, Farah

    2014-01-01

    This study investigates the role of laboratory animals in preclinical research, where the application of these animals has the purpose to assess the safety and determine the dosage of new medicaments. In addition, the study discusses the impediments in implementing the 3R’s (replacement, reduction and refinement) in the research. The animals are used as human models due to their close similarities in anatomical and physical properties. To confine the research with laboratory animals, the E...

  3. Animal Models of Compulsive Eating Behavior

    OpenAIRE

    Matteo Di Segni; Enrico Patrono; Loris Patella; Stefano Puglisi-Allegra; Rossella Ventura

    2014-01-01

    Eating disorders are multifactorial conditions that can involve a combination of genetic, metabolic, environmental, and behavioral factors. Studies in humans and laboratory animals show that eating can also be regulated by factors unrelated to metabolic control. Several studies suggest a link between stress, access to highly palatable food, and eating disorders. Eating “comfort foods” in response to a negative emotional state, for example, suggests that some individuals overeat to self-medica...

  4. Introduction of Chinese Traditional and Herbal Drugs

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The journal published monthly since January 1970 is an academic and technical journal sponsored by Chinese Pharmaceutical Association and Tianjin Institute of Pharmaceutical Research (TIPR). The journal which has a long history of 40-years offers the columns of research papers brief reports, reviews, dissertation, and special treatises to report the recent achievements of our basic study, production quality control, and clinic application on traditional Chinese medicine and Chinese materia medica.

  5. Diagnostic Work-up and Follow-up in Children with Tall Stature: A Simplified Algorithm for Clinical Practice

    OpenAIRE

    Stalman, Susanne E.; Pons, Anke; Wit, Jan M; Kamp, Gerdine A.; Plötz, Frans B.

    2015-01-01

    Objective: No evidence-based guideline has been published about optimal referral criteria and diagnostic work-up for tall stature in children. The aim of our study was to describe auxological and clinical characteristics of a cohort of children referred for tall stature, to identify potential candidates for adult height reduction, and to use these observations for developing a simple algorithm for diagnostic work-up and follow-up in clinical practice. Methods: Data regarding family and medica...

  6. Diurnal variation of flow-mediated dilatation in healthy humans

    OpenAIRE

    Kim, Yong Cheol; Yun, Kyeong Ho; Woo, Sun Ho; Jeong, Young Hoon; Lim, Jae Hong; Hwang, Kyo Bum; Jeong, Jin Woo; Lee, Mi Rim; Lee, Jeong Mi; Rhee, Sang Jae; Kim, Nam-Ho; Oh, Seok Kyu; Jeong, Jin-Won

    2015-01-01

    Introduction The measurement of flow-mediated dilatation (FMD) via ultrasound has been established as a reliable non-invasive measurement of endothelial function. However, the guidelines mention nothing regarding diurnal variation of FMD. Thus, we investigated the FMD in healthy people and diurnal variation of FMD. Methods Twenty-five apparently healthy persons participated in this study. All participants had no history of cardiovascular diseases, hypertension, or diabetes and used any medica...

  7. Effect of three different calcium hydroxide mixtures (calcium hydroxide with glycerine, normal saline and distilled water) on root dentin microhardness

    OpenAIRE

    Hasheminia SM; Norouzynasab S

    2007-01-01

    Background and Aim: During root canal therapy, it is necessary to remove as many bacteria as possible from the root canal. The use of medicaments is recommended to reduce the microbial population prior to root filling. Calcium hydroxide pastes have been used because of their antibacterial effects and the ability of tissue dissolving. The aim of this study was to evaluate the effect of calcium hydroxide/glycerine mixture, calcium hydroxide/normal saline mixture and calcium hydroxide/distilled ...

  8. Identification and Expression Analysis of BURP Domain-Containing Genes in Medicago truncatula

    OpenAIRE

    Li, Yuan; Chen, Xue; Chen, Zhu; Cai, Ronghao; Zhang, Hongmei; Xiang, Yan

    2016-01-01

    BURP domain-containing proteins belong to a newly identified protein class that is unique to plants and plays an important role in plant development and metabolism. Although systematic characterization of BURP domain-containing proteins have been carried out in many species, such as rice, poplar and maize, little is known about BURP domain-containing proteins in Medicago. In this study, multiple bioinformatics approaches were employed to identify all the members of BURP family genes in Medica...

  9. Effects of sulfur-based hemostatic agents and gingival retraction cords handled with latex gloves on the polymerization of polyvinyl siloxane impression materials

    OpenAIRE

    MACHADO, Carlos Eduardo Palhares; GUEDES, Carlos Gramani

    2011-01-01

    Objectives This study investigated the possible interactions between three addition silicone materials (Express®, Aquasil Ultra® and Adsil®), three hemostatic agents (ferric sulfate, StatGel FS®; aluminum sulfate, GelCord®; and aluminum chloride, Hemostop®) and gingival retraction cords previously handled with latex gloves to determine whether direct contact with medicaments or indirect contamination by latex in conditions similar to those found in clinical practice inhibit or affect the sett...

  10. Effects of sulfur-based hemostatic agents and gingival retraction cords handled with latex gloves on the polymerization of polyvinyl siloxane impression materials

    OpenAIRE

    Carlos Eduardo Palhares Machado; Carlos Gramani Guedes

    2011-01-01

    OBJECTIVES: This study investigated the possible interactions between three addition silicone materials (Express®, Aquasil Ultra® and Adsil®), three hemostatic agents (ferric sulfate, StatGel FS®; aluminum sulfate, GelCord®; and aluminum chloride, Hemostop®) and gingival retraction cords previously handled with latex gloves to determine whether direct contact with medicaments or indirect contamination by latex in conditions similar to those found in clinical practice inhibit or affect the set...

  11. A review of the British Journal of Sports Medicine 1991-5.

    OpenAIRE

    Thompson, B

    1996-01-01

    OBJECTIVE: To review 5 years of the British Journal of Sports Medicine (BJSM) to assess the nature of articles published, look at which specialities and nationalities were contributing most frequently, and analyse the numbers of subjects involved in the studies. METHODS: Data were collated from all original papers, review articles, and case reports from March 1991 to December 1995. RESULTS: Authors from 35 different countries contributed a total of 282 papers in the 5 year period, with medica...

  12. Hydrogen potassium adenosine triphosphatase activity inhibition and downregulation of its expression by bioactive fraction DLBS2411 from Cinnamomum burmannii in gastric parietal cells

    OpenAIRE

    Tjandrawinata RR; Nailufar F; Arifin PF

    2013-01-01

    Raymond R Tjandrawinata1,2, Florensia Nailufar2, Poppy F Arifin11Section of Molecular Pharmacology, 2Section of Animal Pharmacology, Dexa Medica, Cikarang, IndonesiaAbstract: This study assessed the gastric acid antisecretory effect of DLBS2411 fractionated from Cinnamomum burmannii. Hydrogen potassium adenosine triphosphatase (H+/K+ ATPase) activity and its gene expression were observed, and the antioxidant activity of DLBS2411 was also investigated. Treatment of DLBS2411 decreased the level...

  13. R-(+)-ABP a novel derivative of 3-n-butyl-phthalide possesses anti-convulsant and neuroprotective properties in rodents

    Institute of Scientific and Technical Information of China (English)

    ELESTAGE; A.ROGER; L.DANOBER; ERENARD; X-Q.PENG; Z.GUO; J.T.ZHANG

    2004-01-01

    ABP is a novel phthalide derivative of 3-n-butyl-phthalide (NBP) synthesized at the Beijing Institute of Materia Medica.NBP was isolated from several plants including Apium graveolens Linn. The juice squeezed from fresh celery leaves has long been used in Southeastern China for the treatment of epilepsy, and NBP has been reported to possess anti-convulsant properties (Drugs Future 2000; 25: 16-23). The present study

  14. Addition of Adult-to-Adult Living Donation to Liver Transplant Programs Improves Survival but at an Increased Cost1-2

    OpenAIRE

    Northup, Patrick G.; Abecassis, Michael M; Englesbe, Michael J.; Emond, Jean C.; Lee, Vanessa D.; Stukenborg, George J.; Tong, Lan; Berg, Carl L.

    2009-01-01

    We performed a cost-effectiveness analysis exploring the cost and benefits of LDLT using outcomes data from the Adult to Adult Living Donor Liver Transplantation Cohort Study (A2ALL). A multistage Markov decision analysis model was developed with treatment strategies including medical management only (strategy 1), waiting list with possible deceased donor liver transplant (strategy 2), and waiting list with possible LDLT or DDLT (strategy 3) over ten years. Decompensated cirrhosis with medica...

  15. A CORRELATIVE STUDY OF FNAC THYROID WITH THYROID HORMONE PROFILE

    Directory of Open Access Journals (Sweden)

    Ritica

    2014-02-01

    Full Text Available BACKGROUND: Study aims to determine correlation of the cytological pattern of t hyr oid lesions in ad di t ion to the ut i l it y a nd accu r ac y o f F N A C a s in i t ia l dia g nostic me thod a lo n g with t hy roid h o rmone p ro f i l e ( T 3, T4 a nd TSH whi c h p r ovides info r mation a t p hy sio log i ca l a nd p a tho l o g ic a l lev e ls a nd thus ca n e nh a n c e the l i k e l i hood o f ea r l y de te c t i on of a mb ig uous t hyr oid dy sfu nc t i on with m i ni ma l clin ica l findin gs. OBJECTIVES: To obtain role of thyroid hormone profile (T3, T4 and TSH aimed at defining prognostic parameters and correlating it with cytology r e sul t s, dia g nosis of dif f use n o n t o xi c g oi te r, dia g nos i s of sol i ta ry /do m inant t hy roid nodule, c onfi r mation of c l i nic a l l y obvious t hyr oid ma l ig n anc y . MATERIALS AND METHODS: 150 patients with thyroid sw ellings underwent FNAC along with c omp le te t hy roid ho r mone p r o f i l e in Central Diagnostic Lab o f A JI MS Man ga lor e . P r oce d u re w a s p e r f o r med without L .A with the he lp of a spir a t i ng t ec hnique usi n g 23G nee dle a t tache d to 10 ml di s posa b le sy ri nge . An avera ge of one a t te mpt p e r nodule w a s p e r fo rm e d usual l y re sul t ing in 4 dir ec t sme a rs. B oth a ir d r ied a nd w e t fi xe d sme a rs fi xe d in 95% a l c ohol for a bout 30 m i n ute s a nd stain e d with Le ish ma n ’ s stain a nd Pa p stain e x a m i n e d und e r l ig ht m icr osco pe . T hy roid p ro file is a lso p e r f o r med in a ll the a bo v e p a t ie nts. RESULTS: One hund re d a nd fi ft y a spir a t i ons of p a t ie nts (both f e m a les a nd mal e s w er e analyse d. T 3, T4 a nd TSH w a s analy z e d f o r a ll 150 p a t ie nts . The me a n ag e of p a t ie nts in t his stu d y w a s 39.66 year s a nd ag e rang e w a s 1 - 76 yea rs. The r e w er e 142 femal e s (94. 6 6% a nd 8 mal e s (5.3 3% . M ax i m um nu m b e r of

  16. The Correlation between Chemical Composition, as Determined by UPLC-TOF-MS, and Acute Toxicity of Veratrum nigrum L. and Radix paeoniae alba

    Directory of Open Access Journals (Sweden)

    Xianxie Zhang

    2014-01-01

    Full Text Available The eighteen incompatible medicaments is an important theory in traditional Chinese medicine. The theory suggests that drugs in the eighteen incompatible medicaments can be toxic when used together. Veratrum nigrum L. and Radix paeoniae alba belong to the eighteen incompatible medicaments and have been prohibited for thousands of years. This study offers preliminary insight into the mechanism and chemical constituents responsible for the incompatibility and toxicity of these two agents. Specifically, we performed toxicology studies to identify and quantify the constituent substances of the two agents. Experiments revealed that acute toxicity increases when the dose of V. nigrum L. is higher than, or equal to, RPA. UPLC-TOF-MS analysis showed that, although the volumes of V. nigrum L. were the same, the content of some veratrum alkaloids changed significantly and had a trend toward a highly positive correlation r≥0.8 with toxicity. This suggests that the increased toxicity of the V. nigrum L. and RPA combination was due mainly to increased content of the special veratrum alkaloids. The cytotoxicity of veratridine in SH-SY5Y cells was decreased with increasing paeoniflorin concentrations. This study provides insight into the mechanism behind the incompatibility theory of TCM.

  17. Serviço de emergências psiquiátricas em hospital geral universitário: estudo prospectivo Psychiatric emergency service in a school general hospital: a prospective study

    Directory of Open Access Journals (Sweden)

    Maria Eugênia de SB dos Santos

    2000-10-01

    Full Text Available OBJETIVO: Realizar estudo transversal de serviço regionalizado de emergências psiquiátricas inserido em hospital universitário de emergências pela caracterização da clientela e do atendimento. MÉTODOS: Os dados foram colhidos por um protocolo, sendo considerados todos os atendimentos realizados durante dois meses. RESULTADOS: Foram preenchidos 600 protocolos que corresponderam a 96,5% dos atendimentos efetuados no período estudado, referentes a 487 pacientes. A maioria desses era do sexo masculino, sem vínculos conjugais, com baixa escolaridade, profissionalmente inativa e morava com familiares. Os diagnósticos mais freqüentes foram transtorno do uso de substância psicoativa (26,3%, esquizofrenias (15,5%, episódio maníaco (11,8%, depressão maior (10,9% e transtornos não psicóticos (10,9%, havendo diferenças entre os sexos quanto à proporção de algumas categorias diagnósticas. Após o atendimento inicial, 2/3 recebeu medicação e 1/2 permaneceu em observação, sendo que 1/4 permaneceu mais de 10h no serviço. Cerca de 20% dos atendimentos resultaram em internação integral e 60%, em encaminhamentos para seguimento ambulatorial. Alta por evasão representou apenas 2,0% dos atendimentos. Os usuários repetitivos não diferiram daqueles que tiveram atendimento único quanto a estado civil, vínculo empregatício e condições de moradia, mas apresentaram maior freqüência de internações anteriores e de transtornos psicóticos. CONCLUSÕES: O serviço atendeu pacientes com quadros psiquiátricos graves, em real situação de urgência, sendo observada uma ampliação das funções do serviço de emergências psiquiátricas e sua efetiva inserção na rede pública de serviços de saúde mental.OBJECTIVES: The aim was to carry out a prospective study about the characteristics of the public seen at a psychiatric emergency room and of its service. METHODS: The data were acquired though a protocol developed for this study and

  18. A relação da postura corporal com a prosódia na doença de parkinson: estudo de caso The relations between body posture and prosody in Parkinson's disease: case study

    Directory of Open Access Journals (Sweden)

    Fernanda Vargas Ferreira

    2007-09-01

    Full Text Available OBJETIVO: investigar a associação entre a postura corporal e a prosódia em indivíduos com Doença de Parkinson. MÉTODOS: estudo de corte transversal realizado com cinco sujeitos com Doença de Parkinson da cidade de Santa Maria, Estado do Rio Grande do Sul, em 2006. Utilizaram-se avaliações da prosódia lingüística e emocional bem como da postura corporal. A análise estatística utilizada foi descritiva. RESULTADOS: foram estudados quatro sujeitos do sexo masculino e um sujeito do sexo feminino com idades entre 37 e 53 anos. Três sujeitos encontravam-se no estágio I, um sujeito no estágio III e um sujeito no estágio IV da doença conforme a escala de classificação da função motora Hohen &Yahr, todos sob o uso de medicação e apresentando os sinais da tríade característica da patologia (rigidez, tremor, bradicinesia bem como as alterações posturais típicas. Na comparação entre prosódia emocional e prosódia lingüística, encontrou-se melhor desempenho na prosódia emocional e não se evidenciou associação entre os estágios da patologia e alterações na postura corporal e prosódia. CONCLUSÃO: as alterações posturais são sinais característicos da Doença de Parkinson, assim como alterações na prosódia lingüística e emocional. A ocorrência de alterações posturais foi elevada entre os parkinsonianos. Os sujeitos apresentaram melhor performance na prosódia emocional. Não houve evidências de que os estágios da doença estivessem associados às alterações da prosódia e da postura corporal.PORPOSE: to investigate the relationship between body posture and prosody in patients with Parkinson Disease. METHODS: the study was carried out with five patients (four males and one female from Santa Maria, Rio Grande do Sul, Brazil, by means of cross-section study, in 2006. Evaluations of linguistic and emotional prosody as well as analysis of body posture were carried out. The statistical analysis was descriptive

  19. Oral lysine clonixinate in the acute treatment of migraine: a double-blind placebo-controlled study Clonixinato de lisina oral para o tratamento agudo da migrânea: estudo duplo-cego e placebo-controlado

    Directory of Open Access Journals (Sweden)

    Abouch V. Krymchantowski

    2001-03-01

    Full Text Available Several oral nonsteroidal anti-inflammatory drugs (NSAIDs are effective to treat migraine attacks. Lysine clonixinate (LC is a NSAID derived from nicotinic acid that has proven to be effective in various pain syndromes such as renal colic and muscular pain. The aim of this double-blind, placebo-controlled study was to evaluate the efficacy of oral LC compared to placebo in the acute treatment of migraine. Sixty four patients with the diagnosis of migraine, according to the IHS criteria, were studied prospectively. Patients received LC or placebo once the headache reached moderate or severe intensity for 6 consecutive attacks. With regard to the moderate attacks, LC was superior than placebo after 1, 2 and 4 hours. The consumption of other rescue medications after 4 hours was significantly higher in the placebo group. With regard to the severe attacks, there was no difference between the active drug group and the placebo group concerning headache intensity and consumption of other rescue medications. We conclude that the NSAID lysine clonixinate is effective in treating moderately severe migraine attacks. It is not superior than placebo in treating severe migraine attacks.Alguns antinflamatórios não esteroidais (AINEs são eficazes para o tratamento de crises de migrânea. O clonixinato de lisina (CL é um AINE derivado do ácido nicotínico comprovadamente eficaz no tratamento de várias síndromes dolorosas como a cólica renal e a dor muscular. O objetivo deste estudo duplo-cego placebo-controlado foi avaliar a eficácia do CL oral comparado ao placebo no tratamento agudo da migrânea. Sessenta e quatro pacientes com o diagnóstico de migrânea, de acordo com os critérios da Sociedade Internacional de Cefaléia (IHS, foram estudados prospectivamente. Os pacientes receberam CL ou placebo quando a cefaléia atingiu a intensidade moderada ou severa em 6 crises consecutivas. Para as crises moderadas, o CL foi superior ao placebo em 1, 2 e 4

  20. Fostering Effective Studying and Study Planning with Study Questions

    Science.gov (United States)

    Wilhelm, Pascal; Pieters, Jules M.

    2007-01-01

    In a course on biological psychology and neuropsychology, study questions were provided that also appeared as test questions in the course exam. This method was introduced to support students in active processing and reproduction of the study texts, and study planning. Data were gathered to test the hypothesis that study question use would be…

  1. Discoloration and color's reversion of Scot pine veneers by resin-eliminated treatment

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The discoloration of Scot pine (Pinus sylvestris var. Mongolica) veneers caused by resin-eliminated treatment and the reversion of the color were studied. The result showed that the color of the veneers changed from buff to yellowish brown after the treatment of resin elimination and the discoloration of heartwood was more severe than that of sapwood; the degree of discoloration was significantly positively correlated with the medicament strength, temperature and resin-eliminated duration. The variance analysis showed the effects of those three factors on the discoloration were significant. With hydrogen peroxide ( H2O2 ) as color reversion medicament and inorganic compound as medium of the reaction, the reversion of the color of heartwood was more inaccessible than that of sapwood; the degree of the color's reversion was positively correlated with the H2O2strength, temperature and treating time; the H2O2 concentration has significant effects on the discoloration. In order to reduce discoloration of Scot pine veneers, medicament of resin-eliminated used have to be at some low concentration, and the optimal concentration of H2O2 is 0.35% during the process of color's reversion.

  2. [History of incompability among medicinals of "Glycyrrhiza antagonistic to Sargassum, Euphorbia Pekinensis, Kansui, and Genkwa" and its modern recognition].

    Science.gov (United States)

    Jiang, Chenxue; Bian, Yali; Fan, Xinsheng

    2015-05-01

    The allegation of "Glycyrrhiza antagonistic to Sargassum, Euphorbia Pekinensis, Kansui, and Genkwa", being one of the hypotheses of "18 antagonisms" in TCM pharmacology, is referring to the antagonistic action among the Radix et Rhizoma Glycyrrhiza and Radix Euphorbiae Kansui, Radix Euphorbiae Pekinensis, Flos Genkwa, and Sargassum when compounded together in a single recipe. By reviewing its history concerted with modern knowledge, it can be found that the theory of "seven emotions" was originated from Shennong's Classic of Materia Medica; while the Variorum of the Classic of Materia Medica firstly and definitely records that Radix et Rhizoma Glycyrrhizae is forbidden to be used with Radix Kansui, Flos Genkwa, Radix Euphorbiae Pekinensis, Sargassum together in a single formula. It was summarized into a Chinese poetic sentence as above-mentioned later. In the works of later ages, including Chinese Pharmacopoeia, A Great Dictionary of Chinese Materia Medica, and China's Herbology, etc., all enhance the understanding of the prohibited combination of Radix et Rhizoma Glycyrrhizae and its incompatible herbs. Nevertheless, there are discrepancies between the results of modern experimental and clinical studies on this problem, which, needless to say, should be resolved by further investigations. PMID:26420521

  3. The effect of 4% Lignocaine gel, 5% Amiloride HCl and 10% Chlorpromazine on E.faecalis

    Directory of Open Access Journals (Sweden)

    Udayakumar Jayasimha Raj

    2011-01-01

    Full Text Available Introduction : Thorough disinfection of the root canal system is essential for the success of root canal therapy. Enterococcus faecalis is the most frequently found species in persistent/secondary intracanal infection associated endodontic treatment failure. The aim of this study was to evaluate the disinfection of dentinal tubules using 10% Chlorpromazine, 4% Lignocaine gel, 5% Amiloride hydrochloride in comparison with 2% chlorhexidine gel. Materials and Methods : The antibacterial efficacy of the four medicaments against Enterococcus faecalis was assessed in vitro using extracted human first and second mandibular premolar teeth at the depths of 200 ΅m and 400 ΅m. Results : The overall percentage inhibition of bacterial growth was 100% with 2% chlorhexidine gel followed by 10% chlorpromazine (88.8%, 4% lignocaine gel (76.4% and 5% amiloride hydrochloride (71.4%. Conclusion : 2% chlorhexidine gel was most effective against E. faecalis followed by the newer non- antibiotic medicament 10% chlorpromazine when compared to the other medicaments tested.

  4. Effects of irrigation solutions and Calcium hydroxide dressing on root canal treatments of periapical lesions

    Directory of Open Access Journals (Sweden)

    Vita Nirmala

    2006-03-01

    Full Text Available The preparation of root canal in endodontic treatment plays an important role in treating non vital teeth with periapical lesion. Some factors influence the success of root canal treatment in short and long terms are the irrigation of root canal using antiseptic solution and the use of root canal medicament. The aim of this literature study is to determined the effect of irrigation solution and Calcium hydroxide dressing in root canal treatment of periapical lesions. The use of root canal medicament during the endodontic treatment could sterilized and decreased the number of pathogenic microorganism of root canal. An effective root canal irrigation solution must be able to dissolve organic and anorganic debris, lubricate endodontic instruments, disinfect microorganisms, non toxic and economical. The best irrigation solution has maximum antimicrobial effect with minimum toxicity. Division of calcium hydroxide into Calcium and hydroxyl ions is responsible for alkalinization of cavity, subsequently it makes the condition of cavity to be inappropriate for bacterial endotoxin in vitro as well as in vivo, and considered as the only clinically effective medicament in inactivating bacterial endotoxin. Calcium hydroxide is the only medication which has the ability to clinically inactive bacterial endotoxin in vitro in vivo and accepted as the best of root canal medication.

  5. Synthetic and biological studies on a cyclopolypeptide of plant origin

    Institute of Scientific and Technical Information of China (English)

    Rajiv DAHIYA; Akhilesh KUMAR

    2008-01-01

    Objective: A natural cyclic peptide previously isolated from Citrus medica was synthesized by coupling oftetrapep-tide units Boc-Leu-Pro-Trp-Leu-Ome and Boc-Ile-Ala-Ala-Gly-Ome after proper deprotection at carboxyl and amino terminals followed by cyclization of linear octapeptide segment.Methods: Solution phase technique was adopted for the synthesis of cyclooctapeptide--sarcodactylamide.Required tetrapeptide units were prepared by coupling of Boc-protected dipeptides viz.Boc-Leu-Pro-OH and Boc-Ile-Ala-OH with respective dipeptide methyl esters Trp-Leu-Ome and Ala-Gly-Ome.Cyclization of linear octapeptide unit was done by p-nitrophenyl ester method.The structure of synthesized cyclopolypeptide was elucidated by FTIR,1H NMR,13C NMR,FABMS spectral data and elemental analysis.The newly synthesized peptide was evaluated for dif-ferent pharmacological activities including antimicrobial,anthelmintic and cytotoxic activities.Results: Synthesis of sarcodac-tylamide was accomplished with >78% yield utilizing dicyclohexylcarbodiimide (DCC) as coupling agent.Newly synthesized peptide possessed potent cytotoxic activity against Dalton's lymphoma ascites (DLA) and Ehrlich's ascites carcinoma (EAC) cell lines,in addition to moderate anthelmintic activity against earthworms Megascoplex konkanensis,Pontoscotex corethruses and Eudrilus sp.Moreover,cyclopolypeptide displayed good antimicrobial activity against pathogenic fungi Candida albicans and Gram-negative bacteria Pseudomonas aeruginosa,in comparison to standard drugs griseofulvin and ciprofloxacin.Conclusion: Solution phase technique employing DCC and triethylamine (TEA) as base proved to be effective for the synthesis of natural cyclooctapeptide.N-methyl morpholine (NMM) was found to be a better base for the cyclization of linear octapeptide unit in comparison to TEA and pyridine.

  6. O processo de comunicação na administração de medicações injetáveis em crianças sob a perspectiva da interação entre mãe-criança e auxiliares de enfermagem El proceso de comunicación en la administración de medicamentos inyectables en niños, bajo la perspectiva de la interacción entre madre-niño y auxiliares de enfermería The communication process in the administration of injection medication to children under the perspective of interaction between mother/children and nursing auxiliaries

    Directory of Open Access Journals (Sweden)

    Viviane Tosta de Oliveira

    1997-10-01

    Full Text Available Neste estudo, de caráter qualitativo, foi analisada a comunicação estabelecida entre mãe-criança-auxiliares de enfermagem durante as situações de aplicações de medicamentos injetáveis em crianças. Foi utilizada a técnica de observação não participante com anotações de campo em doze situações. Os dados foram categorizados segundo o Modelo Teórico de Forrest. Constatou-se o predomínio das categorias bloqueadoras Desaprovação, Depreciação, Tranqüilizando a Mãe com "Clichês" ou Comentários Estereotipados. As categorias facilitadoras apresentaram as subcategorias Reconhecendo os sentimentos e presença da criança e esclarecendo e orientando a mãe ou responsável. Concluiu-se que houve o predomínio no uso das categorias bloqueadoras, quando não foram utilizados recursos de comunicação verbal para interagir com a mãe e criança, não estabelecendo um relacionamento de amizade e confiança e tornando o relacionamento ineficiente.En este estudio de carácter calitativo, fue analizada la comunicación establecida entre madre, niño y auxiliares de enfermeria durante las situaciones de aplicaciones de medicamentos inyectables en niños. Fue utilizada la técnica de observación no participante con anotaciones de campo en doce situaciones. Los datos fueron categorizados según el método teórico de Forrest. Se ha constatado el predominio de las categorías bloqueadoras: desaprobación, deprecio, tranquilizando a la madre con "clichês" o comentarios estereotipados, las categorías facilitadoras presentaron las subcategorías, reconociendo los sentimientos y al niño, esclareciendo y orientando a la madre o responsable. Se concluyó que hubo predominio de uso de las categorías bloquedoras, cuando no fueron utilizados recursos de comunicación verbal para interectuar con la madre y el niño, no estableciendo un relacionamiento de amistad y confianza y tornando el relacionamiento ineficiente.In this qualitative study, we

  7. 金佛手果叶多糖的体外抗氧化活性研究%In vitro Antioxidative Activity of Polysaccharide from Fruit and Leaf of Citrus medica var.sarcodactylis

    Institute of Scientific and Technical Information of China (English)

    杨继; 叶安; 陆智明; 陆国权

    2015-01-01

    测定了金佛手果、叶多糖的体外抗氧化能力,结果显示金佛手果、叶多糖具有良好的抗氧化活性;果、叶多糖对·O2-清除能力的IC50分别为11.83 mg· L-1和12.26 mg· L-1,强于芦丁、弱于Vc;对·OH清除能力IC50分别为11.09 mg·L-1和12.22 mg·L-1,强于芦丁和Vc;不同浓度果、叶多糖对·O2-,·OH清除率差异显著,且随着浓度的增加清除率呈上升趋势,但当浓度超过20 mg·L-1时,清除率趋于平缓.

  8. Regulatory aspects of the medical and occupational exposures in the application of the radiosynoviortesis technique; Aspectos regulatorios de las exposiciones medicas y ocupacionales en la aplicacion de la tecnica de radiosinoviortesis

    Energy Technology Data Exchange (ETDEWEB)

    Dumenigo G, C.; Fuente P, A. de la; Quevedo G, J.R.; Lopez F, Y. [Centro Nacional de Seguridad Nuclear, Calle 28 No. 504 e/5 y 7 Ave. Miramar, Playa, Ciudad de la Habana (Cuba)]. e-mail: cruz@orasen.co.cu

    2006-07-01

    The Radiosynoviortesis is a to therapeutic proceed that consists in the injection of a radiopharmaceutical beta transmitter in the synovial cavity of the articulations affected by arthropaties. With it is achieved to cause the fibrosis and remodeling of the synovial membrane obtaining a remarkable improvement in the patients that it includes the disappearance of the pain and the increase of the flexibility of the treated articulation. The technique began to be carried out from 1952 in Europe when it was injected Au{sup 196} in patients affected by rheumatoid arthropaties and starting from then it has gone winning followers in Canada, United States, Australia and some countries of Latin America. Their results are satisfactory and they have been endorsed by the practice. In Cuba it was carried out at November 16, 2002 a clinical essay with the use of this technique, the same one was Graduate by the National Center of Nuclear Safety, in their condition of Regulatory Authority, for it the National Institute of Hematology and Immunology presented the technical documentation that bases its safety. However for the generalization of this technique and their inclusion in the Nuclear Medicine services already existent, the Regulatory Authority has indicated a group of requirements that should be kept in mind in a such way that the application of the Radiosynoviortesis fulfills the Regulation of those 'Basic Norms of Radiological Safety' effective in our country. The present work exposes the particularities and challenges that the Radiosynoviortesis outlines from the point of view of the Radiological Protection, as well as the technical aspects that should be kept in mind for its Licensing, in such way that the is guaranteed safety of the same one in the relative thing to the radiological protection of the patients, those workers and the one publishes. The work reaffirms the feasibility of this to therapeutic proceed from the point of view of the radiological protection, proposing a group of practical actions that allow to guarantee the radiological safety. (Author)

  9. Oral self-emulsifying drug delivery system and its application to preparations of Chinese materia medica%口服自乳化释药系统及其在中药制剂中的应用

    Institute of Scientific and Technical Information of China (English)

    钱一鑫; 唐景玲; 孙进; 张天虹; 何仲贵

    2006-01-01

    自乳化释药系统是提高强疏水性药物溶出的有效载体系统之一.中药作为国之瑰宝,在防病治病方面有其独特的优势.随着组合化学和高内涵筛选技术的进步,将会发现越来越多的新药.然而诸多中药或化合物因其强疏水性及较低的口服生物利用度,而使其在临床上的应用受到限制,以自乳化释药系统作为该类药物的载体,将会给这一类药物带来巨大的市场潜能.现系统地综述口服自乳化释药系统的研究内容及最新进展.

  10. Proceedings of the 1st Ibero-Latin American and Caribbean Congress on Medical Physics. Mexico 98; Memorias. 1er Congreso Iberolatinoamericano y del Caribe de Fisica Medica. Mexico 98

    Energy Technology Data Exchange (ETDEWEB)

    Gaona, E. [ed.] [Universidad Autonoma Metropolitana, Mexico D.F. (Mexico); Huitron, B.G. [ed.] [Universidad Autonoma del Estado de Mexico, Toluca (Mexico)

    1998-12-31

    This book composes the works received for the 1st Ibero-Latin American and the Caribbean Congress on Medical Physics. There are 68 works which represent a sample of the recent advances of the medical physics which are indicators about the level of development of the speciality in these regions of the world. Thus, the Congress represents the greatest event of medical physics of Ibero-Latin America and the Caribbean besides its consolidation and regional organization. The book also contains useful counsels for the education, yours researches and the daily hospitable practice. (Author)

  11. 基于人眼视觉特性的NSCT医学图像自适应融合%Adaptive MedicaI Image Fusion Based on Human VisuaI Features

    Institute of Scientific and Technical Information of China (English)

    戴文战; 姜晓丽; 李俊峰

    2016-01-01

    医学图像融合对于临床诊断具有重要的应用价值。针对多模态医学图像特性,本文提出一种基于人类视觉特性的医学图像自适应融合方法。首先,对经配准的源图像进行非间隔采样轮廓变换((Nonsubsampled Coutour-let,NSCT)多尺度分解,得到低频子带和若干高频方向子带;其次,根据低频子带集中了大部分源图像能量和决定图像轮廓的特点,采用区域能量与平均梯度相结合的方法进行融合;根据人眼对图像对比度及边缘、纹理的高敏感度,在高频子带系数的选取时提出区域拉普拉斯能量、方向对比度与脉冲耦合神经网络(Pulse Coupled Neural Network,PCNN)相结合的融合策略;进而,提出了把与人类视觉高度一致的加权结构相似度(Weighted Structure Similarity,WSSIM)作为图像融合目标函数,自适应地获取各子带的最优权值;最后,对灰度图像和彩色图像进行了大量融合比较实验,并对不同融合方法进行分析对比。实验结果表明:本文算法不仅可以有效保留源图像的信息,而且可以使融合图像灰度级更分散,更好地保留了图像边缘信息,具有更好的视觉效果。%Medical image fusion has very important application value for medical image analysis and diseases diagno-sis.According to the characteristics of multi modality medical image and human visual features,a new medical image fusion algorithm in NSCT (nonsubsampled coutourlet,NSCT)domain is proposed.Firstly,source images after registration are de-composed into low and high frequency sub-bands using NSCT.According to the low frequency subbands concentrating the majority energy of the source image and determining the image coutour,a fusion rule based on weighted region average ener-gy combined with average gradient is adopted in low frequency subband coefficients.Moreover,according to human visual system which is more sensitive to contrast and edge,texture of image,the fusion strategy based on directive contrast integrat-ed with the improved energy of Laplacian and PCNN (Pulse Coupled Neural Network,PCNN)are used to fuse high-fre-quency subbands.Furthermore,a closed loop feedback is introduced into the fusion rules of low and high frequency subbands to obtain optimal fused weights adaptively by using WSSIM (Weighted Structure Similarity,WSSIM)which highly consist-ent with the HVS(human visual features,HVS)as objective function.Finally,a lot of experiments of fusion of images inclu-ding gray images and color images based on different fusion methods are conducted.The experiment results are analyzed in terms of visual quality and objective evaluation.The experiment results show that the proposed algorithm can effectively pre-serve information and significantly improve the performance of fusion image in terms of quantity of information,dispersed gray scale,visual quality and objective evaluation index.

  12. 抗巢虫药物巢础防治效果实验观察%Experiment on Preventing & Curing Effects of Medicaments' Foundation with Remedy of Resisting Wax-moth Larva

    Institute of Scientific and Technical Information of China (English)

    刘长滔; 徐祖荫; 张久胜; 龙立炎

    2002-01-01

    通过在贵州省锦屏县大同乡对张久胜等3个中蜂场分别用一半上药物巢础、一半上巢虫阻隔器,另将吴作沛等3个场作常规组,进行抗巢虫对比试验,夏秋3次调查结果表明:上药物巢础的蜂群较上阻隔器的蜂群,被害率低0~6.7%,被害蜂群脾均白头蛹少2~5头;较常规组蜂群,被害率低16.7~32.7%,被害蜂群脾均白头蛹少12~24.2头,防治效果明显。实践证明:使用药物巢础防治巢虫,不但防治效果好,而且适用性强,易于推广。

  13. Impact of Different Medicament and Substrate on the Emergence of Moringa Oleifera%不同药剂及基质对辣木出苗率的影响

    Institute of Scientific and Technical Information of China (English)

    智顺; 武新琴

    2010-01-01

    用复方新诺明、高锰酸钾、阿司匹林及清水对辣木种子进行浸种处理,将泥炭土与河沙按不同比例混合形成5种播种基质,进行辣木容器播种育苗试验.试验表明:辣木在泥炭土与河沙的混合基质上育苗均比在纯泥炭土或纯河沙上出苗率高.用高锰酸钾或阿司匹林对种子进行浸种处理.能显著提高种子出苗率.

  14. Effect of Chinese Materia medica on the growth performance and egg quality of laying duck%中药制剂对蛋鸭生产性能及蛋品质的影响

    Institute of Scientific and Technical Information of China (English)

    张磊

    2011-01-01

    研究了中药制剂健胃增蛋散对蛋鸭生产性能及蛋品质的影响.结果表明:该中药制剂具有提高产蛋率,降低料蛋比和降低蛋黄胆固醇含量的作用:试验组与对照组相比,产蛋率明显提高、料蛋比显著降低(P<0.05),其中蛋鸭料蛋比由2.74下降到2.35,降低14.23%,蛋黄胆固醇南49.38 mmol/L下降到32.49 mmol/L,降低34.20%.

  15. Monitoring of doses in hemodynamic medical team with dosemeters calibrated to measure the personal dose equivalent; Monitoracao das doses na equipe medica de hemodinamica com dosimetro calibrado em equivalente de dose pessoal

    Energy Technology Data Exchange (ETDEWEB)

    Alonso, T.C. [Minas Gerais Univ., Belo Horizonte, MG (Brazil). Curso de Ciencias e Tecnicas Nucleares]. E-mail: alonso@cdtn.br; Silva, T.A. da [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN), Belo Horizonte, MG (Brazil)]. E-mail: silvata@cdtn.br

    2005-07-01

    In hemodynamic, the exposure time of the workers to the radiation are larger than in the conventional one. Consequently, the received doses are larger. The dose of the medical team is also affected significantly by the uniqueness of the exams that are accomplished in two ways of irradiation and several angles of incidences, what stands out the need of the dosimeters use with metrologic reliability adapted for such situations. The individual monitoring of the doses received by individuals occupationally exposed to the radiation is accomplished with films dosimeters or thermo luminescent ones, with the main objective to guarantee that the limits of doses are not surpassed. The used in the system Brazilian metrologic system is still the individual dose for photons, in spite of the international recommendations for the use of the equivalent personal dose, that is the greatness adapted to assess the equivalent dose and the effective dose. In this work, the dosimeter composed by the Harshaw-Bicron badge and the detecting thermoluminescent of lithium fluoride was tested and adapted to measure the equivalent of personal dose in the depths 0,07 mm and 10 mm. It was applied in the hemodynamics practices and the doses were compared with those obtained by the routine film dosimeter. The results suggest, for daily use of the interventional services, the indication of the new dosimeter in substitution to the of the type films. (author)

  16. Good agricultural practice (GAP) of Chinese materia medica (CMM) for ten years: achievements, problems and proposals%中药材规范化生产(GAP)10年:成果、问题与建议

    Institute of Scientific and Technical Information of China (English)

    郭兰萍; 张燕; 朱寿东; 王桂华; 王秀; 张小波; 陈美兰; 何雅莉; 韩邦兴

    2014-01-01

    该文旨在总结中药材GAP实施过程中取得的成果,在分析其存在问题的基础上,就中药材GAP的进一步推行提出建议.作者认为中药材GAP推行10年取得了很大成果,包括①颁布了中药材GAP认证的一系列管理办法;②中药材规模化面积不断扩大;③农民及企业规范化种植中药材的意识增强;④形成了一批中药材GAP基地;⑤中药材栽培理论和方法不断完善;⑥培养了一大批中药材GAP生产及认证的专家和学者.GAP生产中存在的问题主要包括:①对GAP及其认证的认识和理解亟需深化;②GAP认证基地布局不够合理;③地缘经济及小农经济耕作是中药材规范化和规模化生产的瓶颈;④比较效益偏低限制了GAP的发展;⑤优良品种选育基础空白;⑥栽培技术不成熟导致生产过程风险较大;⑦土壤微生态恶化及连作障碍制约了中药材GAP基地的可持续发展.为进一步促进中药材GAP健康有序发展,作者提出以下建议:①改变生产模式,全面推动中药材GAP生产;②建立健全中药材标准体系,推行中药材优质优价;③充分考虑地缘经济文化,大力推行中药材定向培育;④强化基础研究和成果转化推广,为中药材生产提供技术保障;⑤深化对GAP的理解,大力推行生态种植和精细农业克服连作障碍.作者认为,虽然仍面临大量管理和技术问题,但中药材GAP早已深入人心,并展现出巨大的前景.未来时日,随着人们对GAP认识理解的不断加深,以及科技的巨大进步,GAP生产将会不断与精准农业、生态农业等现代农业理论、方法及技术融合,并展现出更大的潜力和更广阔的前景.

  17. 我国中药出口 SWOT分析与战略选择——基于胃药的调查%SWOT Analysis and strategic choice for exporting Chinese materia medica based on investigation of gastric medicine

    Institute of Scientific and Technical Information of China (English)

    张丽莉; 高文远; 张铁军; 郑纯林; 闫娟娟

    2007-01-01

    随着经济全球化和国外对中药的认可,国外生产的"洋中药"因科技含量高、产品符合国际标准,大举进入国际医药市场,给我国中药产业带来了巨大的冲击.以治疗胃病的中药为例,对我国中药出口的优势(strengths)、劣势(weakness)、机遇(opportunities)和威胁(threats)进行具体分析,提出了发展我国中药出口的品牌战略、合作和营销战略,以期为我国中药企业产品出口提供借鉴.

  18. Implementation of the learning problems of physics-based medical and radiation protection in a medical school; Implementacion del aprendizaje basado en problemas de la fisica medica y la proteccion radiologica en una facultad de medicina

    Energy Technology Data Exchange (ETDEWEB)

    Munoz Montplet, C.; Casas Curto, J. D.; Pedraza Gutierrez, S.; Vilanova Busquets, J. C.; Balliu Collgros, E.; Barcelo Obregon, J.; Fuentes Raspall, R.; Guirao Marin, S.; Maroto Genover, A.; Pont Valles, J.; Agramunt Chaler, S.; Jurado Bruggeman, D.

    2013-07-01

    The learning objectives related to medical physics and radiation protection work mostly in the module of Radiology and physical medicine of the second year of the curriculum, complemented by a visit to medical physics and radiation protection and radiation oncology at the Hospital services University of reference during the third course. In this paper we present our experience in the design and implementation during the period 2009-2012 of the module focusing in these disciplines. (Author)

  19. 修订适合中药体外致突变性检验的Ames检测体系思路%Thinking of revising Ames system suited to/n vitro mutagenicity test for Chinese materia medica

    Institute of Scientific and Technical Information of China (English)

    金建玲; 刘波; 高培基

    2009-01-01

    Ames测验是遗传毒理实验(致畸致癌致突变)的初筛方法,是食品药品安全性检验中心的必检项目之一.结合部分中药体外致突变性(Ames检测)结果的混乱情况,提出修订现行Ames检测体系的必要性和紧迫性.通过对生物类样品中因含有组氨酸成分对Ames测验结果的影响作用(易产生假阳性)进行深入分析,并对目前国际上相关的Ames检测的修订方法进行综述和比较,指出了目前国内外尚没有适合中药致突变性检验的修订体系.在此基础上,提出了几条修订常规的Arues测验以适合中药体外致突变性检验的思路,以期引起应有的重视.

  20. Situation of the medical physics in the Republic of Argentina. Regulatory problem linked to the requirement of physic specialists; Situacion de la fisica medica en la Republica Argentina. Problematica regulatoria vinculada al requerimiento de especialistas fisicos

    Energy Technology Data Exchange (ETDEWEB)

    Arbor Gonzalez, A.; Larcher, A. [Autoridad Regulatoria Nuclear, Buenos Aires (Argentina)]. E-mail: alarcher@sede.arn.gov.ar; Blanco, S. [Universidad de Buenos Aires (Argentina). Facultad de Ciencias Exactas y Naturales]. E-mail: blanco@ic.fcen.uba.ar

    2001-07-01

    This paper provides up-to-date data on the participation of medical physicists in current staffs for radiotherapy, nuclear medicine and diagnostic radiology in Argentina, and it presents projections on the academic education of specialists in the next five years. At the same time, the regulatory framework including the requirements for physicists staffing levels in medical practices is presented. This panorama permits to stick out the important role of the professional associations and the academic institutions in the development of Medical Physics in the country. (author)