WorldWideScience

Sample records for cancer technical implementation

  1. Whole pelvic helical tomotherapy for locally advanced cervical cancer: technical implementation of IMRT with helical tomothearapy

    International Nuclear Information System (INIS)

    To review the experience and to evaluate the treatment plan of using helical tomotherapy (HT) for the treatment of cervical cancer. Between November 1st, 2006 and May 31, 2009, 10 cervical cancer patients histologically confirmed were enrolled. All of the patients received definitive concurrent chemoradiation (CCRT) with whole pelvic HT (WPHT) followed by brachytherapy. During WPHT, all patients were treated with cisplatin, 40 mg/m2 intravenously weekly. Toxicity of treatment was scored according to the Common Terminology Criteria for Adverse Events v3.0 (CTCAE v3.0). The mean survival was 25 months (range, 3 to 27 months). The actuarial overall survival, disease-free survival, locoregional control and distant metastasis-free rates at 2 years were 67%, 77%, 90% and 88%, respectively. The average of uniformity index and conformal index was 1.06 and 1.19, respectively. One grade 3 of acute toxicity for diarrhea, thrombocytopenia and three grade 3 leucopenia were noted during CCRT. Only one grade 3 of subacute toxicity for thrombocytopenia was noted. There were no grade 3 or 4 subacute toxicities of anemia, leucopenia, genitourinary or gastrointestinal effects. Compared with conventional whole pelvic radiation therapy (WPRT), WPHT decreases the mean dose to rectum, bladder and intestines successfully. HT provides feasible clinical outcomes in locally advanced cervical cancer patients. Long-term follow-up and enroll more locally advanced cervical carcinoma patients by limiting bone marrow radiation dose with WPHT technique is warranted

  2. Technical officer's experience in supporting Technical Cooperation (TC) projects implementation

    International Nuclear Information System (INIS)

    Full text: The Technical Cooperation Department of the IAEA helps to transfer nuclear and related technologies for peaceful use to countries throughout the world. The TC Programme disburses more than US$70 million worth of equipment, services, and training per year in approximately 100 countries and territories which are grouped into four geographic regions. With almost 200 staff members, the TC Department works in full partnership with Technical Officers (TOs) from the Technical Departments within the Agency and project counterparts in the recipient Member States. In addition, TC collaborates with the World Bank and other organizations to plan and execute projects in harmony with Member States' needs. Through training courses, expert missions, fellowships, scientific visits, and equipment disbursement, the Technical Cooperation Programme provides the necessary skills and equipment to establish sustainable technology in the counterpart country or region. With more than 800 on-going projects, the TC Programme strives to have an impact on Member State problems that can be solved with nuclear technology. The role of TOs seems to be just supportive for the entire process. However, do we know, what are the duties of the TO? The role and duties of a TO are usually very much underestimated. Terms as 'technical advice and input' say a little about actual TO's work, who in fact is managing the project, finding and coaching the experts, specifying and organizing expert missions and workshops, working a lot on visits of national consultants and scientific visits, writing terms of reference/statements of work for procurement/subcontracts, performing technical evaluation of tenders, managing the projects dealing with subcontracts, coaching the counterparts, etc., etc. Not having the list above of real TO's duties and activities, one will never estimate in a realistic manner the workload and staff needed or a reasonable number of projects for one TO that can be implemented in a

  3. Epitaxy physical principles and technical implementation

    CERN Document Server

    Herman, Marian A; Sitter, Helmut

    2004-01-01

    Epitaxy provides readers with a comprehensive treatment of the modern models and modifications of epitaxy, together with the relevant experimental and technological framework. This advanced textbook describes all important aspects of the epitaxial growth processes of solid films on crystalline substrates, including a section on heteroepitaxy. It covers and discusses in details the most important epitaxial growth techniques, which are currently widely used in basic research as well as in manufacturing processes of devices, namely solid-phase epitaxy, liquid-phase epitaxy, vapor-phase epitaxy, including metal-organic vapor-phase epitaxy and molecular-beam epitaxy. Epitaxy’s coverage of science and texhnology thin-film is intended to fill the need for a comprehensive reference and text examining the variety of problems related to the physical foundations and technical implementation of epitaxial crystallization. It is intended for undergraduate students, PhD students, research scientists, lecturers and practic...

  4. Prospects of Blended Learning Implementation at Technical University

    OpenAIRE

    Buran, Anna Leonidovna; Evseeva, Arina Mikhailovna

    2015-01-01

    The present paper explores the integration of a blended learning course in the process of learning English as a second language at the technical university. We overview the difference between traditional, web facilitated, blended learning and online course; the implementation of the blended learning course in the process of learning English at the technical university. The article also investigates the benefits and drawbacks of blended learning and the possibilities of a blended learning cour...

  5. Optimizing Cancer Care Delivery through Implementation Science

    Directory of Open Access Journals (Sweden)

    Heather B Neuman

    2016-01-01

    Full Text Available The 2013 Institute of Medicine report investigating cancer care concluded that the cancer care delivery system is in crisis due to an increased demand for care, increasing complexity of treatment, decreasing work force and rising costs. Engaging patients and incorporating evidence-based care into routine clinical practice are essential components of a high quality cancer delivery system. However, a gap currently exists between the identification of beneficial research findings and application in clinical practice. Implementation research strives to address this gap. In this review, we discuss key components of high quality implementation research. We then apply these concepts to a current cancer care delivery challenge in women’s health, specifically the implementation of a surgery decision aid for women newly diagnosed with breast cancer.

  6. IMPLEMENTATION OF TURNOUTS TECHNICAL DIAGNOSTICS SYSTEMS

    Directory of Open Access Journals (Sweden)

    S. YU. Buryak

    2015-06-01

    Full Text Available Purpose. In the paper it is necessary to: 1 find out the causes of turnouts faults to determine diagnostic features failures; 2 consider the requirements structure, purpose components of turnouts, work and technology of their maintenance to determine the construction of the economic activities related to system to the turnout’s maintenance; 3 substantiate the possibility, necessity and prospects of automated diagnostics turnout’s implementation; 4 elaborate a prototype of an automated hardware and software system for the turnouts control parameters and perform diagnostics on them. Methodology. In the paper possible turnouts faults were presented and manifestations and influence on its work were shown. According to the current technology works the process analyze of turnouts’ maintenance was conducted, were defined the basic performed operations during the examination of appearance, parameters and check the repair or replacement of parts and assemblies. Based on the analysis of reasons of turnouts malfunctioning and their fixes were systematized types of damages and ways to deal with them, an information scheme of troubleshooting were created, opportunities and limits of automating the process of diagnostics were identified and compared with the existing method of turnouts maintenance. A diagnostics system block diagram was created, an algorithm of its work was developed and established main basic principles of operation. Software and hardware to determine the turnout’s state considering diagnostic performance of points in use were applied. Findings. During the experiment was created a method of automated turnout’s diagnostics with AC electric drives, managed centrally. The results of automated hardware and software system make it possible to control turnout’s parameters and perform diagnostics on them. Originality. Authors created the method of turnout’s state determination by current curve and its spectral composition in the

  7. Socio-technical considerations in epilepsy electronic patient record implementation.

    LENUS (Irish Health Repository)

    Mc Quaid, Louise

    2010-05-01

    Examination of electronic patient record (EPR) implementation at the socio-technical interface. This study was based on the introduction of an anti-epileptic drug (AED) management module of an EPR in an epilepsy out-patient clinic. The objective was to introduce the module to a live clinical setting within strictly controlled conditions to evaluate its usability and usefulness.

  8. New technology implementation: Technical, economic and political factors

    Science.gov (United States)

    Dean, J. W., Jr.; Susman, G. I.; Porter, P. S.

    1985-01-01

    An analysis is presented of the process of implementing advanced manufacturing technology, based on studies of numerous organizations. This process is seen as consisting of a series of decisions with technical, economic, and political objectives. Frequency decisions involve specifications, equipment, resources/organization, and location. Problems in implementation are viewed as resulting from tradeoffs among the objectives, the tendency of decision makers to emphasize some objectives at the expense of others, and the propensity of problems to spread from one area to another. Three sets of recommendations, based on this analysis, are presented.

  9. Technical Shortcomings of Designing and Implementing a Knowledge Management System

    OpenAIRE

    Mohammadreza Hamidizadeh; Seyed Akbar Nilipour Tabatabaei; Maryam Gholizadeh

    2014-01-01

    The purpose of the current research is to recognize technical shortcomings of designing and implementing a knowledge management system. The research population include two companies: Zobahan Esfahan Company and International Automation and Systems Engineering Company (IRISA) in which the staffs work in different departments such as research and development, method and structure, strategic planning, instruction, and information technology. applying a stratified random sampling, 50 samples were...

  10. Instrument and Survey Analysis Technical Report: Program Implementation Survey. Technical Report #1112

    Science.gov (United States)

    Alonzo, Julie; Tindal, Gerald

    2011-01-01

    This technical document provides guidance to educators on the creation and interpretation of survey instruments, particularly as they relate to an analysis of program implementation. Illustrative examples are drawn from a survey of educators related to the use of the easyCBM learning system. This document includes specific sections on…

  11. Breast cancer screening implementation and reassurance

    DEFF Research Database (Denmark)

    Østerø, J; Siersma, Volkert Dirk; Brodersen, John

    2013-01-01

    difference in reported psychosocial aspects had disappeared or been reduced because of the nationwide screening implementation. METHODS: The 1000 women included in the previous survey were posted part I of the questionnaire Consequences of Screening in Breast Cancer (COS-BC1) in August 2011, nearly 5 years...

  12. Technical Issues in Implementing DTN in a Flight Software Architecture

    Science.gov (United States)

    Oyake, Amalaye

    2007-01-01

    This slide presentation reviews some of the technical issues in implementing Delay Tolerant Networking (DTN) in a enviornments that lack continuous network connectivity, such as spacecraft in deepspace or submarines. In a DTN, asynchronous variable-length messages (called bundles) are routed in a store and forward manner between participating nodes over a heterogeneous network. The review examines the enabling technologies, the porting steps and issues, operational scenarios for DTN. There is a review of the Licklider Transmission Protocol (LTP) aka Long-haul Transmission Protocol. Also included is a brief review of the current uses of DTN.

  13. IMPLEMENTING THE NFPA 805 PROCESS: Observations of a Technical Reviewer

    Energy Technology Data Exchange (ETDEWEB)

    Short, Steven M.; Coles, Garill A.; Bohlander, Karl L.; Layton, Robert F.; Ivans, William J.; dePeralta, Fleurdeliza A.; Lowry, Peter P.

    2015-04-26

    In June 2004 the U.S. Nuclear Regulatory Commission (NRC) amended its fire protection requirements to permit existing nuclear power reactor licensees to voluntarily adopt fire protection requirements contained in National Fire Protection Association (NFPA) Standard 805. NFPA 805 is a performance-based standard for nuclear power plant fire protection that is an alternative to the deterministic, prescriptive fire protection requirements, such as 10 CFR 50 Appendix R, that was issued in 1980. One aspect of implementing NFPA 805 is that the licensee adopts the performance goals, objectives, and criteria for nuclear safety specified in the Standard. These goals, objectives, and criteria can be met through the implementation of deterministic approaches or performance-based approaches, including engineering analyses, probabilistic risk assessment, and fire modeling. Licensees voluntarily adopting the fire protection requirements in NFPA 805 must submit a license amendment request (LAR) to the NRC. The LAR provides the new proposed fire protection licensing basis, including the methodology and results of required evaluations and analyses that show how the NFPA 805 performance criteria are met. As of August 2014, licensees have submitted LARs for 26 nuclear power plants, representing 42 nuclear reactor units. Of these, 7 nuclear power plants, representing 10 nuclear reactor units, have been issued a safety evaluation (SE) by the NRC approving transition of their fire protection licensing basis to one that complies with NFPA 805. Pacific Northwest National Laboratory (PNNL) supports the NRC staff’s technical review of the LARs in the areas of fundamental fire protection, safe shutdown analysis, and Probabilistic Risk Assessment (PRA). PNNL, of course, cannot speak for the nuclear industry and its choice of implementation strategies or the NRC staff’s assessment of the approaches being taken to adopt NFPA 805. However, as a reviewer of the technical details of these

  14. Basic and technical research on lung cancer

    International Nuclear Information System (INIS)

    In association with clinical study of carbon beam therapy for lung cancer, the basic research for lung cancer and the patients with this disease has been carried out for the past 10 years. With regard to lung damage by the carbon beams, firstly pulmonary function was measured and analyzed for the patients with stage I non-small cell lung cancer. Force expiratory volume in 1 second (FVE 1.0) and TLC (total lung capacity) was found to be reduced significantly at 6 and 12 months after therapy but the reduction rate was a little, which can support the safety of this treatment modality. Secondly, the regional lung damage by the beams was investigated by using correct fusion of CT images with carbon beam dose distribution, diagnostic follow-up CT images and blood flow and ventilation spect images. It demonstrated the graded decrease blood flow by dose and the compensatory increase of blood flow in the adjacent lobe of lung unexposed to irradiation. On the other hand, the biological study of carbon beam effects on lung cancer cells and tumors line was conducted. Firstly, by using 7 or 4 human lung cancer cell line, the radiosensitivity of carbon beams was compared with that of photons by different histological patterns. It was found that there was no essential difference in the sensitivity pattern for lung cancer histology between the carbon beams and photons though the former doubled the later in power. Secondly, by using IA cell lines among them, the dynamic of clonogenic cells (clonogen) in a nude tumor and the changes in its morphology following irradiation was investigated, clarifying that the clonogen proliferating under anoxic or hypoxic conditions played a pivotal role for tumor regrowth and stemmed from the different clone which had been genetically selected and developed under these conditions. The finding of clonogen becomes one of the evidence supporting the superiority of a single-dose radiotherapy to fractionated radiotherapy. (author)

  15. Design and Implementation of Equipment Interactive Electronic Technical Manuals

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Interactive electronic technical manuals (IETMs) can significantly improve the maintenance and logistics of modern weapon equipment. Main functiors and development strategies of IETMs are discussed. As an example, the IETM development of a certain equipment is demonstrated.

  16. Tumour stage and implementation of standardised cancer patient pathways

    DEFF Research Database (Denmark)

    Jensen, Henry; Tørring, Marie Louise; Fenger-Grøn, Morten;

    2016-01-01

    BACKGROUND: Some European countries have introduced standardised cancer patient pathways (CPPs), including urgent referrals, with the aim of diagnosing cancer at an earlier stage. This is despite a lack of evidence, particularly in patients with symptomatic cancer diagnosed via general practice....... AIM: To compare tumour stages in patients with incident cancer diagnosed via general practice before, during, and after CPP implementation in Denmark in 2008-2009. DESIGN AND SETTING: A comparative cohort study of data from GPs and registries on patients with incident cancer listed with a GP before (n...... = 1420), during (n = 5272), and after (n = 2988) CPP implementation. METHOD: χ(2) test was used to compare stage distributions and logistic regression to estimate odds ratios (OR) of having local cancer after versus before CPP implementation. RESULTS: Distribution of tumour stages did not differ...

  17. World wide web implementation of the Langley technical report server

    Science.gov (United States)

    Nelson, Michael L.; Gottlich, Gretchen L.; Bianco, David J.

    1994-01-01

    On January 14, 1993, NASA Langley Research Center (LaRC) made approximately 130 formal, 'unclassified, unlimited' technical reports available via the anonymous FTP Langley Technical Report Server (LTRS). LaRC was the first organization to provide a significant number of aerospace technical reports for open electronic dissemination. LTRS has been successful in its first 18 months of operation, with over 11,000 reports distributed and has helped lay the foundation for electronic document distribution for NASA. The availability of World Wide Web (WWW) technology has revolutionized the Internet-based information community. This paper describes the transition of LTRS from a centralized FTP site to a distributed data model using the WWW, and suggests how the general model for LTRS can be applied to other similar systems.

  18. Advancing cervical cancer prevention in India: implementation science priorities.

    Science.gov (United States)

    Krishnan, Suneeta; Madsen, Emily; Porterfield, Deborah; Varghese, Beena

    2013-01-01

    Cervical cancer is the leading cause of cancer mortality in India, accounting for 17% of all cancer deaths among women aged 30 to 69 years. At current incidence rates, the annual burden of new cases in India is projected to increase to 225,000 by 2025, but there are few large-scale, organized cervical cancer prevention programs in the country. We conducted a review of the cervical cancer prevention research literature and programmatic experiences in India to summarize the current state of knowledge and practices and recommend research priorities to address the gap in services. We found that research and programs in India have demonstrated the feasibility and acceptability of cervical cancer prevention efforts and that screening strategies requiring minimal additional human resources and laboratory infrastructure can reduce morbidity and mortality. However, additional evidence generated through implementation science research is needed to ensure that cervical cancer prevention efforts have the desired impact and are cost-effective. Specifically, implementation science research is needed to understand individual- and community-level barriers to screening and diagnostic and treatment services; to improve health care worker performance; to strengthen links among screening, diagnosis, and treatment; and to determine optimal program design, outcomes, and costs. With a quarter of the global burden of cervical cancer in India, there is no better time than now to translate research findings to practice. Implementation science can help ensure that investments in cervical cancer prevention and control result in the greatest impact.

  19. Implementing the Exercise Guidelines for Cancer Survivors

    OpenAIRE

    WOLIN, KATHLEEN Y.; Schwartz, Anna L; Matthews, Charles E.; Courneya, Kerry S.; Schmitz, Kathryn H.

    2012-01-01

    In 2009, the American College of Sports Medicine convened an expert roundtable to issue guidelines on exercise for cancer survivors. This multidisciplinary group evaluated the strength of the evidence for the safety and benefits of exercise as a therapeutic intervention for survivors. The panel concluded that exercise is safe and offers myriad benefits for survivors including improvements in physical function, strength, fatigue, quality of life (QOL), and possibly recurrence and survival. Rec...

  20. Models for local implementation of comprehensive cancer control: meeting local cancer control needs through community collaboration.

    Science.gov (United States)

    Behringer, Bruce; Lofton, Staci; Knight, Margaret L

    2010-12-01

    The comprehensive cancer control approach is used by state, tribes, tribal organizations, territorial and Pacific Island Jurisdiction cancer coalitions to spur local implementation of cancer plans to reduce the burden of cancer in jurisdictions across the country. There is a rich diversity of models and approaches to the development of relationships and scope of planning for cancer control activities between coalitions and advocates in local communities. The national comprehensive cancer control philosophy provides an operational framework while support from the Centers for Disease Control and Prevention enables coalitions to act as catalysts to bring local partners together to combat cancer in communities. This manuscript describes multiple characteristics of cancer coalitions and how they are organized. Two models of how coalitions and local partners collaborate are described. A case study method was used to identify how five different state and tribal coalitions use the two models to organize their collaborations with local communities that result in local implementation of cancer plan priorities. Conclusions support the use of multiple organizing models to ensure involvement of diverse interests and sensitivity to local cancer issues that encourages implementation of cancer control activities. PMID:20938731

  1. New generation of breast cancer clinical trials implementing molecular profiling

    Institute of Scientific and Technical Information of China (English)

    Dimitrios Zardavas; Martine Piccart-Gebhart

    2016-01-01

    The implementation of molecular profiling technologies in oncology deepens our knowledge for the molecular landscapes of cancer diagnoses, identifying aberrations that could be linked with specific therapeutic vulnerabilities. In particular, there is an increasing list of molecularly targeted anticancer agents undergoing clinical development that aim to block specific molecular aberrations. This leads to a paradigm shift, with an increasing list of specific aberrations dictating the treatment of patients with cancer. This paradigm shift impacts the field of clinical trials, since the classical approach of having clinico-pathological disease characteristics dictating the patients' enrolment in oncology trials shifts towards the implementation of molecular profiling as pre-screening step. In order to facilitate the successful clinical development of these new anticancer drugs within specific molecular niches of cancer diagnoses, there have been developed new, innovative trial designs that could be classified as follows: i) longitudinal cohort studies that implement (or not) "nested" downstream trials, 2) studies that assess the clinical utility of molecular profiling, 3) "master" protocol trials, iv) "basket" trials, v) trials following an adaptive design. In the present article, we review these innovative study designs, providing representative examples from each category and we discuss the challenges that still need to be addressed in this era of new generation oncology trials implementing molecular profiling. Emphasis is put on the field of breast cancer clinical trials.

  2. A technical writing programme implemented in a first-year engineering course at KU Leuven

    Science.gov (United States)

    Heylen, Christel; Vander Sloten, Jos

    2013-12-01

    Technical communication and technical writing are important skills for the daily work-life of every engineer. In the first-year engineering programme at KU Leuven, a technical writing programme is implemented within the project-based course 'Problem Solving and Engineering Design'. This paper describes a case study for implementing a writing programme based on active learning methods and situated learning in large classes. The programme consists of subsequent cycles of instructions, learning by doing and reflection on received feedback. In addition, a peer-review assignment, together with an interactive lecture using clicking devices, is incorporated within the assignments of the second semester. A checklist of desired writing abilities makes it easier to grade the large number of papers. Furthermore, this ensures that all staff involved in the evaluation process uses the same criteria to grade and for providing feedback.

  3. Implications of Incessant Strike Actions on the Implementation of Technical Education Programme in Nigeria

    Science.gov (United States)

    Adavbiele, J. A.

    2015-01-01

    This paper was designed to x-ray the implications of incessant strike actions on the implementation of Technical education programme in Nigeria. The paper took an exploratory view on the concept of strike actions in Nigeria with particular references on notable strike actions that have occurred in Nigeria. The types of strike were explained and…

  4. Implementation of quality improvement techniques for management and technical processes in the ACRV project

    Science.gov (United States)

    Raiman, Laura B.

    1992-01-01

    Total Quality Management (TQM) is a cooperative form of doing business that relies on the talents of everyone in an organization to continually improve quality and productivity, using teams and an assortment of statistical and measurement tools. The objective of the activities described in this paper was to implement effective improvement tools and techniques in order to build work processes which support good management and technical decisions and actions which are crucial to the success of the ACRV project. The objectives were met by applications in both the technical and management areas. The management applications involved initiating focused continuous improvement projects with widespread team membership. The technical applications involved applying proven statistical tools and techniques to the technical issues associated with the ACRV Project. Specific activities related to the objective included working with a support contractor team to improve support processes, examining processes involved in international activities, a series of tutorials presented to the New Initiatives Office and support contractors, a briefing to NIO managers, and work with the NIO Q+ Team. On the technical side, work included analyzing data from the large-scale W.A.T.E.R. test, landing mode trade analyses, and targeting probability calculations. The results of these efforts will help to develop a disciplined, ongoing process for producing fundamental decisions and actions that shape and guide the ACRV organization .

  5. Radiotherapy in Palliative Cancer Care: Development and Implementation

    International Nuclear Information System (INIS)

    on Cancer, the International Union against Cancer and the International Network for Cancer Treatment and Research (INCTR), to design, implement and integrate comprehensive and cost effective national cancer programmes across all areas of cancer control and treatment, including palliative care. It is important to note that palliative care is not only care of the dying, since even with advanced and disseminated cancer, patients are now living longer. The goal of palliative care is to relieve symptoms effectively and efficiently and to maintain the maximum quality of life for the duration of the patient's life. The interventions recommended depend on the patient's clinical status, severity of disease, and the location of the symptomatic site. Radiotherapy has an important role to play as a cost effective and simple method to relieve symptoms caused by bone or brain metastases, tumour bleeding, or visceral/lymphovascular obstruction due to cancer. This report was written following an IAEA consultants meeting in October 2007 and further electronic communications. The aims of the discussions were to: recognize and document the diversity and complexity of cancer types, rates, diagnoses and treatments worldwide; and to provide guidelines to ensure optimum delivery of comprehensive palliative cancer care. This report makes five recommendations: 1. The management and control of cancer symptoms is needed in all health care systems. There is a shortage of palliative care specialists in all health systems, relative to the number of cancer patients needing palliative care. 2. Because palliative care specialists can reach only a small proportion of the patients in need, palliative care principles and techniques should form a core element of the medical education for all health care providers, and especially for those who regularly treat cancer patients. 3. There is a specific need for training in comprehensive palliative care amongst the radiation oncology community. Radiation

  6. What implementation interventions increase cancer screening rates? a systematic review

    Directory of Open Access Journals (Sweden)

    Lent Barbara

    2011-09-01

    Full Text Available Abstract Background Appropriate screening may reduce the mortality and morbidity of colorectal, breast, and cervical cancers. However, effective implementation strategies are warranted if the full benefits of screening are to be realized. As part of a larger agenda to create an implementation guideline, we conducted a systematic review to evaluate interventions designed to increase the rate of breast, cervical, and colorectal cancer (CRC screening. The interventions considered were: client reminders, client incentives, mass media, small media, group education, one-on-one education, reduction in structural barriers, reduction in out-of-pocket costs, provider assessment and feedback interventions, and provider incentives. Our primary outcome, screening completion, was calculated as the overall median post-intervention absolute percentage point (PP change in completed screening tests. Methods Our first step was to conduct an iterative scoping review in the research area. This yielded three relevant high-quality systematic reviews. Serving as our evidentiary foundation, we conducted a formal update. Randomized controlled trials and cluster randomized controlled trials, published between 2004 and 2010, were searched in MEDLINE, EMBASE and PSYCHinfo. Results The update yielded 66 studies new eligible studies with 74 comparisons. The new studies ranged considerably in quality. Client reminders, small media, and provider audit and feedback appear to be effective interventions to increase the uptake of screening for three cancers. One-on-one education and reduction of structural barriers also appears effective, but their roles with CRC and cervical screening, respectively, are less established. More study is required to assess client incentives, mass media, group education, reduction of out-of-pocket costs, and provider incentive interventions. Conclusion The new evidence generally aligns with the evidence and conclusions from the original systematic

  7. Students' Strengths and Weaknesses in Evaluating Technical Arguments as Revealed through Implementing Calibrated Peer Review™ in a Bioengineering Laboratory

    Science.gov (United States)

    Volz, Tracy; Saterbak, Ann

    2009-01-01

    In engineering fields, students are expected to construct technical arguments that demonstrate a discipline's expected use of logic, evidence, and conventions. Many undergraduate bioengineering students struggle to enact the appropriate argument structures when they produce technical posters. To address this problem we implemented Calibrated Peer…

  8. Development and technical implementation of the separation nozzle process for enrichment of uranium 235

    International Nuclear Information System (INIS)

    The separation nozzle process for the enrichment of uranium-235 has been developed at the Karlsruhe Nuclear Research Center as an alternative to the gaseous diffusion and centrifuge process. The separation of uranium isotopes is achieved by the deflection of a jet of uranium hexafluoride mixed with hydrogen. Since 1970, the German company of STEAG, has been involved in the technological development and commercial implementation of the nozzle process. In 1975, the Brazilian company of NUCLEBRAS, and the German company of Interatom, joined the effort. The primary objective of the common activity is the construction of a separation nozzle demonstration plant with an annual capacity of about 200 000 SWU and the development of components of a commercial plant. The paper covers the most important steps in the development and the technical implementation of the process. (orig.)

  9. Implementation pathway report: Community Resource Person An intervention by the Technical Support Unit Uttar Pradesh, India, February 2015

    OpenAIRE

    Girase, BA; Dwivedi, P.; A Srivastava; Bhattacharya, SK; Avan, BI

    2015-01-01

    A report describing the methodology behind an implementation pathway for the Community Resource Person innovation being implemented by the Technical Support Unit (a large-scale collaboration between the Bill & Melinda Gates Foundation and the Uttar Pradesh government) in Uttar Pradesh, India.

  10. Individual and setting level predictors of the implementation of a skin cancer prevention program: a multilevel analysis

    Directory of Open Access Journals (Sweden)

    Brownson Ross C

    2010-05-01

    Full Text Available Abstract Background To achieve widespread cancer control, a better understanding is needed of the factors that contribute to successful implementation of effective skin cancer prevention interventions. This study assessed the relative contributions of individual- and setting-level characteristics to implementation of a widely disseminated skin cancer prevention program. Methods A multilevel analysis was conducted using data from the Pool Cool Diffusion Trial from 2004 and replicated with data from 2005. Implementation of Pool Cool by lifeguards was measured using a composite score (implementation variable, range 0 to 10 that assessed whether the lifeguard performed different components of the intervention. Predictors included lifeguard background characteristics, lifeguard sun protection-related attitudes and behaviors, pool characteristics, and enhanced (i.e., more technical assistance, tailored materials, and incentives are provided versus basic treatment group. Results The mean value of the implementation variable was 4 in both years (2004 and 2005; SD = 2 in 2004 and SD = 3 in 2005 indicating a moderate implementation for most lifeguards. Several individual-level (lifeguard characteristics and setting-level (pool characteristics and treatment group factors were found to be significantly associated with implementation of Pool Cool by lifeguards. All three lifeguard-level domains (lifeguard background characteristics, lifeguard sun protection-related attitudes and behaviors and six pool-level predictors (number of weekly pool visitors, intervention intensity, geographic latitude, pool location, sun safety and/or skin cancer prevention programs, and sun safety programs and policies were included in the final model. The most important predictors of implementation were the number of weekly pool visitors (inverse association and enhanced treatment group (positive association. That is, pools with fewer weekly visitors and pools in the enhanced

  11. Implementation of tissue microarrays technique for cancer research in Cuba

    Directory of Open Access Journals (Sweden)

    Tania Lahera-Sánchez

    2015-08-01

    Full Text Available The tissue microarray (TMA technique is based on making cylindrical cores from paraffin donor blocks and transfer to a single recipient block. The TMA has revolutionized the field of pathology for the possibility to evaluate multiple samples in one slide. There is no precedent of this subject in Cuba, so the objective of this research was to implement the TMA technique. The concordance of the results obtained by complete section and the TMA were evaluated for this purpose, in the evaluation of the estrogen receptors (ER, progesterone (PR and epidermal growth factor type 2 (HER2 in samples of breast cancer. Forty-five paraffin-embedded samples from women diagnosed with breast cancer at the Institute of Oncology in 2012 were studied. Two TMA blocks were constructed, and subsequently the expression of markers ER, PR and HER2 was determined by immunohistochemistry, in the complete section of tissue and in the TMA. Kappa index was used for concordance analysis. A good concordance was obtained for all three markers (ER k=0.8272; PR k=0.793 and HER2 k=0.716. This study constitutes the first report on the TMA technique in Cuba and shows that it is a valuable tool, suggesting its potential use in translational research and clinical trials on vaccines.

  12. Socio-Technical Implementation: Socio-technical Systems in the Context of Ubiquitous Computing, Ambient Intelligence, Embodied Virtuality, and the Internet of Things

    NARCIS (Netherlands)

    Nijholt, A.; Whitworth, B.; de Moor, A.

    2009-01-01

    In which computer science world do we design and implement our socio-technical systems? About every five or ten years new computer and interaction paradigms are introduced. We had the mainframe computers, the various generations of computers, including the Japanese fifth generation computers, the ro

  13. Pilot Implementation of Breast Cancer Early Detection Programs in Colombia

    OpenAIRE

    Murillo, Raúl; Díaz, Sandra; Sánchez, Oswaldo; Perry, Fernando; Piñeros, Marion; Poveda, César; Salguero, Edgar; Osorio, Dimelza

    2008-01-01

    Breast cancer is increasing in developing countries, and Colombia has a double burden from cervical and breast cancer. Suitable guidelines for breast cancer early detection are needed, and the Breast Health Global Initiative provides a favorable framework for breast cancer control in low resource nations. The Colombian National Cancer Institute developed evidence-based guidelines for breast cancer early detection in which coordinated early detection in symptomatic women and hospital-based scr...

  14. Determinants of successful implementation of population-based cancer screening programmes

    DEFF Research Database (Denmark)

    Lynge, Elsebeth; Törnberg, Sven; von Karsa, Lawrence;

    2012-01-01

    consider when planning, implementing and running population based cancer screening programmes. The list is general and is applicable to breast, cervical and colorectal cancer screening. It is based on evidence presented in the three European Union guidelines on quality assurance in cancer screening......) piloting or trial implementation, (5) scaling up from pilot to service, (6) running of full-scale programme, and (7) sustainability. For each phase, a substantial number of specified conditions have to be met. Successful implementation of a cancer screening programme requires societal acceptance and local...

  15. Cancer pharmacogenomics, challenges in implementation, and patient-focused perspectives

    OpenAIRE

    Patel JN

    2016-01-01

    Jai N Patel Department of Cancer Pharmacology, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, USA Abstract: Cancer pharmacogenomics is an evolving landscape and has the potential to significantly impact cancer care and precision medicine. Harnessing and understanding the genetic code of both the patient (germline) and the tumor (somatic) provides the opportunity for personalized dose and therapy selection for cancer patients. While germline DNA is useful in understandin...

  16. Cancer pharmacogenomics, challenges in implementation, and patient-focused perspectives

    Directory of Open Access Journals (Sweden)

    Patel JN

    2016-07-01

    Full Text Available Jai N Patel Department of Cancer Pharmacology, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, USA Abstract: Cancer pharmacogenomics is an evolving landscape and has the potential to significantly impact cancer care and precision medicine. Harnessing and understanding the genetic code of both the patient (germline and the tumor (somatic provides the opportunity for personalized dose and therapy selection for cancer patients. While germline DNA is useful in understanding the pharmacokinetic and pharmacodynamic disposition of a drug, somatic DNA is particularly useful in identifying drug targets and predicting drug response. Molecular profiling of somatic DNA has resulted in the current breadth of targeted therapies available, expanding the armamentarium to battle cancer. This review provides an update on cancer pharmacogenomics and genomics-based medicine, challenges in applying pharmacogenomics to the clinical setting, and patient perspectives on the use of pharmacogenomics to personalize cancer therapy. Keywords: oncology, personalized, pharmacogenetics, germline, somatic, DNA, biomarker

  17. Socio-Technical Implementation: Socio-technical Systems in the Context of Ubiquitous Computing, Ambient Intelligence, Embodied Virtuality, and the Internet of Things

    OpenAIRE

    Nijholt, A.; Whitworth, B.; Moor, A. de

    2009-01-01

    In which computer science world do we design and implement our socio-technical systems? About every five or ten years new computer and interaction paradigms are introduced. We had the mainframe computers, the various generations of computers, including the Japanese fifth generation computers, the role of artificial intelligence and the hype of expert systems. Moreover, we had the advent of personal computers, the first hobby and ‘garage’ computers, leading to companies such as Atari, Apple an...

  18. Survey update on implementation, indications, and technical performance of computed tomography colonography in Sweden

    Energy Technology Data Exchange (ETDEWEB)

    Fisichella, Valeria A.; Hellstroem, Mikael (Dept. of Radiology, Sahlgrenska Univ. Hospital and Sahlgrenska Academy at Univ. of Goeteborg, Goeteborg (Sweden)), e-mail: valeria.fisichella@vgregion.se

    2010-01-15

    Background: Computed tomographic colonography (CTC) has gained increased acceptance in the last few years as a valid substitute for double-contrast barium enema (DCBE). However, implementation of new technologies is complex, since several factors may influence the process. Purpose: To evaluate the current situation in Sweden concerning implementation of CTC, as compared to a previous national survey in 2005. Material and Methods: In December 2008, a structured, self-assessed questionnaire regarding implementation and technical performance of CTC was mailed to all radiology departments in Sweden. In March 2009, departments who had not replied were contacted by e-mail or by telephone. All (100%, 119/119) departments answered the questionnaire. Results: CTC is currently performed in 50/119 (42%) departments, i.e., 18 additional departments compared to 2005. Twenty-three out of 60 (38%) responding departments stated that they intend to start to perform CTC in the near future. DCBE is currently performed in 77/119 (65%) departments, 12 departments less compared to 2005. The most common reasons for non-implementation of CTC are non-availability of spiral CT scanner (41%, 26/64) and/or multidetector-row CT scanner (39%, 25/64), and lack of doctors' time (34%, 22/64). Only 3% (2/64) of departments are 'awaiting further scientific documentation' on CTC, a significant reduction compared to 2005 (P=0.002). Until 2009, 59% (29/49) of CTC centers had performed more than 200 CTCs compared to 13% (4/32) of CTC centers in 2005. Intravenous contrast material is routinely administered in 86% (42/49), and carbon dioxide is used to distend the colon in 90% (44/49). Almost all radiology departments (93%, 93/100) currently believe that CTC will 'absolutely' or 'probably' replace barium enema in the future, while in 2005 only 56% (55/99) gave similar answers. Conclusion: The survey reflects a further transition process from DCBE to CTC, with attitudes

  19. Real-Time MRI Navigated Ultrasound for Preoperative Tumor Evaluation in Breast Cancer Patients: Technique and Clinical Implementation.

    Science.gov (United States)

    Park, Ah Young; Seo, Bo Kyoung

    2016-01-01

    Real-time magnetic resonance imaging (MRI) navigated ultrasound is an image fusion technique to display the results of both MRI and ultrasonography on the same monitor. This system is a promising technique to improve lesion detection and analysis, to maximize advantages of each imaging modality, and to compensate the disadvantages of both MRI and ultrasound. In evaluating breast cancer stage preoperatively, MRI and ultrasound are the most representative imaging modalities. However, sometimes difficulties arise in interpreting and correlating the radiological features between these two different modalities. This pictorial essay demonstrates the technical principles of the real-time MRI navigated ultrasound, and clinical implementation of the system in preoperative evaluation of tumor extent, multiplicity, and nodal status in breast cancer patients. PMID:27587958

  20. Technical phosphoproteomic and bioinformatic tools useful in cancer research.

    Science.gov (United States)

    López, Elena; Wesselink, Jan-Jaap; López, Isabel; Mendieta, Jesús; Gómez-Puertas, Paulino; Muñoz, Sarbelio Rodríguez

    2011-01-01

    Reversible protein phosphorylation is one of the most important forms of cellular regulation. Thus, phosphoproteomic analysis of protein phosphorylation in cells is a powerful tool to evaluate cell functional status. The importance of protein kinase-regulated signal transduction pathways in human cancer has led to the development of drugs that inhibit protein kinases at the apex or intermediary levels of these pathways. Phosphoproteomic analysis of these signalling pathways will provide important insights for operation and connectivity of these pathways to facilitate identification of the best targets for cancer therapies. Enrichment of phosphorylated proteins or peptides from tissue or bodily fluid samples is required. The application of technologies such as phosphoenrichments, mass spectrometry (MS) coupled to bioinformatics tools is crucial for the identification and quantification of protein phosphorylation sites for advancing in such relevant clinical research. A combination of different phosphopeptide enrichments, quantitative techniques and bioinformatic tools is necessary to achieve good phospho-regulation data and good structural analysis of protein studies. The current and most useful proteomics and bioinformatics techniques will be explained with research examples. Our aim in this article is to be helpful for cancer research via detailing proteomics and bioinformatic tools. PMID:21967744

  1. Technical Report: Algorithm and Implementation for Quasispecies Abundance Inference with Confidence Intervals from Metagenomic Sequence Data

    Energy Technology Data Exchange (ETDEWEB)

    McLoughlin, Kevin [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-01-11

    This report describes the design and implementation of an algorithm for estimating relative microbial abundances, together with confidence limits, using data from metagenomic DNA sequencing. For the background behind this project and a detailed discussion of our modeling approach for metagenomic data, we refer the reader to our earlier technical report, dated March 4, 2014. Briefly, we described a fully Bayesian generative model for paired-end sequence read data, incorporating the effects of the relative abundances, the distribution of sequence fragment lengths, fragment position bias, sequencing errors and variations between the sampled genomes and the nearest reference genomes. A distinctive feature of our modeling approach is the use of a Chinese restaurant process (CRP) to describe the selection of genomes to be sampled, and thus the relative abundances. The CRP component is desirable for fitting abundances to reads that may map ambiguously to multiple targets, because it naturally leads to sparse solutions that select the best representative from each set of nearly equivalent genomes.

  2. Implementation of a lung radiosurgery program: technical considerations and quality assurance in an Australian institution

    International Nuclear Information System (INIS)

    The Peter MacCallum Cancer Centre has established a stereotactic lung radiosurgery program for the treatment of isolated lung metastases. The aim of this study was to critically assess the technical feasibility of performing stereotactic lung radiosurgery in an Australian institution. A single 26-Gy fraction of radiotherapy was delivered to patients with positron emission tomography (PET) staged solitary lung metastases. Motion management was addressed using four-dimensional computed tomographic simulation, and cone beam CT (CBCT) online soft-tissue matching. Treatments were with multiple coplanar and non-coplanar asymmetric beams. Patients were immobilised in a dedicated stereotactic body cradle. Quality assurance (QA) of treatment plans with both ion chamber and film measurements was performed accounting for patient-specific respiratory motion. Between February 2010 and February 2011, nine patients received stereotactic lung radiosurgery. One grade 1 toxicity and one grade 2 toxicity were recorded after treatment. The mean planning target volume was 22.6 cc. A median of eight beams were delivered per treatment plan (range 7–10) with a median of two non-coplanar beams (range 0–6). At treatment plan QA, the difference between planned and delivered dose was ≤1.76% in all static and dynamic ion chamber recordings. A mid-treatment CBCT was performed at a median time of 21 min, with the mean displacement discrepancy from initial set-up being 0.4 mm (range 0–2 mm). Stereotactic radiosurgery to the lung was both feasible and tolerable at our institution. Intrafractional immobilisation within 2 mm was reproducible. Excellent concordance between planned and delivered treatments was achieved in the phantom QA.

  3. Breast and cervical cancer screening programme implementation in 16 countries

    DEFF Research Database (Denmark)

    Dowling, Emily C; Klabunde, Carrie; Patnick, Julietta;

    2010-01-01

    There is a continuing need to monitor and evaluate the impact of organized screening programmes on cancer incidence and mortality. We report results from a programme assessment conducted within the International Cancer Screening Network (ICSN) to understand the characteristics of cervical screeni...

  4. Design and Implementation of Agro-technical Extension Information System Based on Cloud Storage

    OpenAIRE

    Guo, Leifeng; Wang, Wensheng; Yang, Yong; Sun,Zhiguo

    2013-01-01

    International audience In order to solve the problems of low efficiency and backward methods in the agro-technical extension activities, this paper designed an agro-technical extension information system based on cloud storage technology. This paper studied the key technologies, such as cloud storage service engine, cloud storage management node and cloud storage data node and designed the overall architecture of the agro-technical extension information system based on cloud storage techno...

  5. Technical and ethical challenges of fertility preservation in young cancer patients.

    Science.gov (United States)

    Deepinder, Fnu; Agarwal, Ashok

    2008-06-01

    As cancer treatment improves, more young men and women survive, but they suffer from infertility as a major sequel of cancer treatment. Gamete and embryo cryopreservation are the only options available to these patients for preserving their fertility. Although cryopreservation of spermatozoa and embryos are already established, oocyte banking is still experimental. The advent of testicular tissue cryopreservation and spermatogonial stem cell transplantation in men, and ovarian tissue cryopreservation and in-vitro follicular maturation in women, has started a frenzy of experiments worldwide trying to demonstrate their potential use in fertility preservation. Although major improvements have been made in tissue cryobanking in the past decade, there are still many unresolved technical issues related to these procedures. Furthermore, the intersection of cancer and fertility preservation in young patients raises ethical, legal and policy issues for oncologists and cancer survivors. Informed consent of minor patients, legal parentage and medical negligence claims are some of the potential legal challenges faced by society and healthcare providers. This review summarizes the technical and ethical challenges of gamete cryopreservation in young cancer patients.

  6. Technical procedures for the implementation of cultural resource site studies, Deaf Smith County, Texas: Preliminary draft

    Energy Technology Data Exchange (ETDEWEB)

    1987-09-30

    Cultural resources at the Deaf Smith County site will be identified, evaluated and managed through the implementation of studies detailed in the Site Study Plan for Cultural Resources. This technical procedure outlines the conduct of pedestrian survey and the documentation of identified cultural resources. The purpose of the field surveys is to identify and document cultural resources in the areas that will be affected by site characterization activities and to record the environmental setting of identified cultural resources. Three pedestrian surveys will cover 100 percent of the on-site and off-site project areas. Survey 1 will provide coverage of the Repository Surface Facility (RSF) area, which includes the Exploratory Shaft Facility (ESF) and two linear engineering design borehole (EDBH) seismic survey corridors. Survey 2 will provide coverage of a 39 km/sup 2/ (15 mi/sup 2/) area that includes the 23 km/sup 2/ (9 mi/sup 2/) Deaf Smith County site plus a 0.4 to 0.8 kM (1/4 to 1/2 mi) border area but excludes the area covered by Survey 1. Survey 3 will cover offsite geotechnical test areas, such as the locations of playa boreholes, deep playa wells, hydrologic tests, site foundation borings, and their access routes. The purpose of site documentation or recording is to address the project information needs for land use permits and approvals, engineering design support, and cultural resource evaluation for National Register of Historic Places eligibility. Site documentation will consist of gathering sufficient data on identified resources to complete Texas Natural Resource Information System (TNRIS). 7 refs., 3 figs.

  7. Implementation of proteomics for cancer research: past, present, and future.

    Science.gov (United States)

    Karimi, Parisa; Shahrokni, Armin; Ranjbar, Mohammad R Nezami

    2014-01-01

    Cancer is the leading cause of the death, accounts for about 13% of all annual deaths worldwide. Many different fields of science are collaborating together studying cancer to improve our knowledge of this lethal disease, and find better solutions for diagnosis and treatment. Proteomics is one of the most recent and rapidly growing areas in molecular biology that helps understanding cancer from an omics data analysis point of view. The human proteome project was officially initiated in 2008. Proteomics enables the scientists to interrogate a variety of biospecimens for their protein contents and measure the concentrations of these proteins. Current necessary equipment and technologies for cancer proteomics are mass spectrometry, protein microarrays, nanotechnology and bioinformatics. In this paper, we provide a brief review on proteomics and its application in cancer research. After a brief introduction including its definition, we summarize the history of major previous work conducted by researchers, followed by an overview on the role of proteomics in cancer studies. We also provide a list of different utilities in cancer proteomics and investigate their advantages and shortcomings from theoretical and practical angles. Finally, we explore some of the main challenges and conclude the paper with future directions in this field. PMID:24761843

  8. Implementation of the scientific evidence into daily practice - example from fast-track colonic cancer surgery

    DEFF Research Database (Denmark)

    Hammer, J.; Harling, H.; Wille-Jorgensen, P.

    2008-01-01

    Objective To report the implementation and results of fast-track surgery for colonic cancer in the daily routine. Method A total of 131 consecutive patients scheduled for elective colonic cancer resections entered a fast-track perioperative course after thorough information. The regimen contained...

  9. [Technical limits of PET/CT with 18FDG in prostate cancer].

    Science.gov (United States)

    von Mallek, D; Backhaus, B; Müller, S C; Matthies, A; Palmedo, H; Jaeger, U; Biersack, H-J; Reinhardt, M

    2006-05-01

    There is increasing evidence that (18)FDG-PET is not useful for the imaging of primary prostate cancer. The aim of this examination was to prove whether or not these poor results are due to technical deficiencies of the examination method like older image reconstruction techniques, extensive (18)FDG-tracer activity in the bladder or improper contrast staining of the rectum. We examined three patients with primary prostate cancer using a modern combined PET/CT system, continuous irrigation of the bladder and an air-inflated rectal balloon catheter. PET/CT images show an exact depiction of both the prostate and all surrounding anatomic structures but no enhanced uptake of radiotracer in the tumour. Therefore, the mentioned poor results of (18)FDG-PET seem not to be due to technical deficiencies.

  10. Setting technical and economic features regarding nuclear heating plants implementation for heat supply in Romania by the year 2010

    International Nuclear Information System (INIS)

    This paper presents the world wide preoccupation concerning the implementation of nuclear heating plants for fulfilling the heat demand and the main technical data of the reactors destined to such NHP's. The second part of this paper shows technical and economic aspects related to the implementation of NHP's equipped with nuclear thermal reactor specialized in the exclusive heat supply in Romania at the level of the year 2010. Among these aspects the following are mentioned: - the results of researches and the world wide achievements; - the development and structure of the production and of the thermal electric energy as well as the feasibility for covering the demands for nuclear sources; - the impact on environment of various technologies for the production of thermal energy with conventional fuels comparing with NHP; - the philosophy from economic stand point for the covering part of the NHP heat demand. (authors)

  11. The NASA Scientific and Technical Information (STI) Program's Implementation of Open Archives Initiation (OAI) for Data Interoperability and Data Exchange

    Science.gov (United States)

    Rocker, JoAnne; Roncaglia, George J.; Heimerl, Lynn N.; Nelson, Michael L.

    2002-01-01

    Interoperability and data-exchange are critical for the survival of government information management programs. E-government initiatives are transforming the way the government interacts with the public. More information is to be made available through web-enabled technologies. Programs such as the NASA's Scientific and Technical Information (STI) Program Office are tasked to find more effective ways to disseminate information to the public. The NASA STI Program is an agency-wide program charged with gathering, organizing, storing, and disseminating NASA-produced information for research and public use. The program is investigating the use of a new protocol called the Open Archives Initiative (OAI) as a means to improve data interoperability and data collection. OAI promotes the use of the OAI harvesting protocol as a simple way for data sharing among repositories. In two separate initiatives, the STI Program is implementing OAI In collaboration with the Air Force, Department of Energy, and Old Dominion University, the NASA STI Program has funded research on implementing the OAI to exchange data between the three organizations. The second initiative is the deployment of OAI for the NASA technical report server (TRS) environment. The NASA TRS environment is comprised of distributed technical report servers with a centralized search interface. This paper focuses on the implementation of OAI to promote interoperability among diverse data repositories.

  12. Technical issues and new devices of ESD of early gastric cancer

    Institute of Scientific and Technical Information of China (English)

    Wan Sik Lee; Jin Woong Cho; Young Dae Kim; Kyu Jong Kim; Byung Ik Jang

    2011-01-01

    Endoscopic submucosal dissection (ESD) is a highly refined technique compared to conventional endoscopic mucosal resection. It enables complete resection of early gastric cancer (EGC) which has no possibility of lymph node metastasis. Indication for ESD of EGC generally entails early gastric cancer confined to the mucosa with well differentiated histology, though there are clinically suitable expanded criteria. As ESD requires specific skill and expertise, endoscopists need to be familiarized with basic methods and the use of special devices. The essence of the technique is to dissect the submucosal layer with direct vision and maintain the cutting plane above the underlying proper muscle layer. Although there are some differences in the detailed technical aspect, the cardinal method of ESD is now well established and standardized. Furthermore, research and development of new ESD devices that render more efficient, safe ESD are still in progress to improve the overall result of ESD on early gastric cancer.

  13. Survivorship care planning in a comprehensive cancer center using an implementation framework.

    Science.gov (United States)

    Garcia, Sofia F; Kircher, Sheetal M; Oden, Megan; Veneruso, Aubri; McKoy, June M; Pearman, Timothy; Penedo, Frank J

    2016-05-01

    Cancer survivorship care plans (SCPs) have been recommended to improve clinical care and patient outcomes. Research is needed to establish their efficacy and identify best practices. Starting in 2015, centers accredited by the American College of Surgeons Commission on Cancer must deliver SCPs to patients completing primary cancer treatment with curative intent. We describe how we established routine SCP delivery at the Robert H Lurie Comprehensive Cancer Center in Chicago, Illinois, using the Quality Implementation Framework. We evaluated local practices, gathered clinician and patient stakeholder input, developed customized SCP templates within the electronic health record (EHR), and implemented 2 complementary delivery models. Clinician interviews (n = 41) and survey responses (n = 12), along with input from patients (n = 68) and a patient advisory board (n = 15), indicated support for SCPs and survivorship services. To promote feasible implementation and leverage existing workflows, we harmonized 2 SCP delivery models: integrated care within clinics where patients received treatment, and referral to a centralized survivorship clinic. We are implementing SCP delivery with prominent disease sites and will extend services to survivors of other cancers in the future. We developed four electronic disease-specific SCP templates for breast, colorectal, lung, and prostate cancers and a fifth, generic template that can be used for other malignancies. The templates reduced free-text clinician entry by auto-populating 20% of the fields from existing EHR data, and using drop-down menus for another 65%. Mean SCP completion time is 12 minutes (range, 10-15; n = 64). We designed our framework to facilitate ongoing evaluation of implementation and quality improvement. Funding/sponsorship Robert H Lurie Comprehensive Cancer Center, the Coleman Foundation, and the Lynn Sage Cancer Research Foundation. PMID:27258051

  14. Technical aspects of the deep inspiration breath-hold technique in the treatment of thoracic cancer

    International Nuclear Information System (INIS)

    Purpose: The goal of this paper is to describe our initial experience with the deep inspiration breath-hold (DIBH) technique in conformal treatment of non-small-cell lung cancer with particular emphasis on the technical aspects required for implementation. Methods and Materials: In the DIBH technique, the patient is verbally coached through a modified slow vital capacity maneuver and brought to a reproducible deep inspiration breath-hold level. The goal is to immobilize the tumor and to expand normal lung out of the high-dose region. A physicist or therapist monitors and records patient breathing during simulation, verification, and treatment using a spirometer with a custom computer interface. Examination of internal anatomy during fluoroscopy over multiple breath holds establishes the reproducibility of the DIBH maneuver for each patient. A reference free-breathing CT scan and DIBH planning scan are obtained. To provide an estimate of tumor motion during normal tidal breathing, additional scan sets are obtained at end inspiration and end expiration. These are also used to set the spirometer action levels for treatment. Patient lung inflation is independently verified over the course of treatment by comparing the distance from the isocenter to the diaphragm measured from the DIBH digitally reconstructed radiographs to the distance measured on the portal films. Patient breathing traces obtained during treatment were examined retrospectively to assess the reproducibility of the technique. Results: Data from the first 7 patients, encompassing over 250 treatments, were analyzed. The inferred displacement of the centroid of gross tumor volume from its position in the planning scan, as calculated from the spirometer records in over 350 breath holds was 0.02 ± 0.14 cm (mean and standard deviation). These data are consistent with the displacements of the diaphragm (-0.1 ± 0.4 cm; range, from -1.2 to 1.1 cm) relative to the isocenter, as measured on the (92) portal films

  15. Technical economic feasibility study for the implementation of a nuclear power plant for the production of electricity in Colombia

    International Nuclear Information System (INIS)

    A study on the technical and economic feasibility will be used to implement a nuclear power in Colombia to generate electricity. To this will be searched if there are previous studies on this topic and what they concluded. The manner in which power is supplied will be discussed in a national level nowadays, its strengths and weaknesses. It will be investigated the legal norms that exists in the country on nuclear power and renewable energy sources, the standards established at world level, the nuclear accidents and the great examples. Providers will be sought on the world market nuclear equipment which serve to this purpose and the technical characteristics of these equipment will be discussed. The type of fuel used in nuclear reactors, its origin, method of production, specifications, availability and long-term and safe handling and final disposal are considered. safe handling of this technology and policy or international rules that will studied

  16. The result of implementation of multidisciplinary teams in rectal cancer

    DEFF Research Database (Denmark)

    Wille-Jørgensen, Peer; Sparre, Peter; Glenthøj, Anders;

    2013-01-01

    Aim:  In 2003 colorectal multidisciplinary teams (MDT) were established in all major Danish hospitals treating colorectal cancer. The aim was to improve the prognosis by a multidisciplinary evaluation and decision about surgical and oncological treatment, based on medical history, clinical...... examination, imaging, histology, and comorbidity.The present study evaluated the effect of the introduction of colorectal MDT on 1.8.2004 in two Danish hospitals. Method:  A retrospective cohort study was conducted comparing the outcome during the last three years before introduction of the MDT with the first...

  17. Technical analysis, contestation and politics in policy agenda setting and implementation

    NARCIS (Netherlands)

    Koduah, Augustina; Dijk, van Han; Agyepong, Irene Akua

    2016-01-01

    Background: Why issues get on the policy agenda, move into policy formulation and implementation while others drop off in the process is an important field of enquiry to inform public social policy development and implementation. This paper seeks to advance our understanding of health policy agen

  18. Spacelab user implementation assessment study. (Software requirements analysis). Volume 2: Technical report

    Science.gov (United States)

    1976-01-01

    The engineering analyses and evaluation studies conducted for the Software Requirements Analysis are discussed. Included are the development of the study data base, synthesis of implementation approaches for software required by both mandatory onboard computer services and command/control functions, and identification and implementation of software for ground processing activities.

  19. Technical and clinical breast cancer screening performance indicators for computed radiography versus direct digital radiography

    Energy Technology Data Exchange (ETDEWEB)

    Bosmans, Hilde; Lemmens, Kim; Zanca, Federica; Ongeval, Chantal van; Steen, Andre van [University Hospitals Leuven, Department of Radiology, Leuven (Belgium); Hauwere, An de; Thierens, Hubert [Ghent University, QCC, Ghent (Belgium); Herck, Koen van; Bleyen, Luc; Mortier, Griet [Ghent University, Centrum voor Preventie en Vroegtijdige Opsporing van Kanker, Department of Public Health, Ghent (Belgium); Martens, Patrick [Vroegtijdige Opsporing Borstklierkanker West-Vlaanderen vzw, Bruges (Belgium); Putte, Gretel vande; Kellen, Eliane; Limbergen, Erik van [Leuven University Center of Cancer Screening, Leuven (Belgium)

    2013-10-15

    To compare technical and clinical screening performance parameters between computed radiography (CR) and direct digital radiography (DR) systems. The number of women screened with CR was 73,008 and with DR 116,945. Technical and patient dose survey data of 25 CR and 37 DR systems were available. Technical performance was expressed by threshold thickness values at the mean glandular dose (MGD) level of routine practice. Clinical indicators included recall rate (RR), cancer detection rate (CDR), percentage of ductal carcinoma in situ (DCIS), percentage of cancers with T-scores smaller than 1 cm and positive predictive value (PPV). Contrast threshold values for the 0.1-mm gold disk were 1.44 {mu}m (SD 0.13 {mu}m) for CR and 1.20 {mu}m (SD 0.13 {mu}m for DR). MGD was 2.16 mGy (SD 0.36 mGy) and 1.35 mGy (SD 0.32 mGy) for CR and DR respectively. We obtained for CR, respectively DR, the following results: RR in the first round of 5.48 % versus 5.61 %; RR in subsequent rounds of 2.52 % versus 2.65 %; CDR of 0.52 % versus 0.53 %; DCIS of 0.08 % versus 0.11 %; a rate of cancers with T-scores smaller than 1 cm of 0.11 % versus 0.11 %; PPV of 18.45 % versus 18.64 %; none of them was significantly different. Our screening indicators are reassuring for the use of CR and DR, with CR operating at 60 % higher MGD. (orig.)

  20. EUROSAFE Forum for nuclear safety. Towards Convergence of Technical Nuclear Safety Practices in Europe. Safety Improvements - Reasons, Strategies, Implementation

    Energy Technology Data Exchange (ETDEWEB)

    Erven, Ulrich (ed.) [Gesellschaft fuer Anlagen- und Reaktorsicherheit, GRS mbH, Schwertnergasse 1, 50667 Koeln (Germany); Cherie, Jean-Bernard (ed.) [Institut de Radioprotection et de Surete Nucleaire, IRSN, BP 17, 92262 Fontenay-aux-Roses Cedex (France); Boeck, Benoit De (ed.) [Association Vincotte Nuclear, AVN, Rue Walcourt 148, 1070 Bruxelles (Belgium)

    2005-07-01

    The EUROSAFE Forum for Nuclear Safety is part of the EUROSAFE approach, which consists of two further elements: the EUROSAFE Tribune and the EUROSAFE Web site. The general aim of EUROSAFE is to contribute to fostering the convergence of technical nuclear safety practices in a broad European context. This is done by providing technical safety and research organisations, safety authorities, power utilities, the rest of the industry and non-governmental organisations mainly from the European Union and East-European countries, and international organisations with a platform for the presentation of recent analyses and R and D in the field of nuclear safety. The goal is to share experiences, to exchange technical and scientific opinions, and to conduct debates on key issues in the fields of nuclear safety and radiation protection. The EUROSAFE Forum on 2005 focused on Safety Improvements, Reasons - Strategies - Implementation, from the point of view of the authorities, TSOs and industry. Latest work in nuclear installation safety and research, waste management, radiation safety as well as nuclear material and nuclear facilities security carried out by GRS, IRSN, AVN and their partners in the European Union, Switzerland and Eastern Europe are presented. A high level of nuclear safety is a priority for the countries of Europe. The technical safety organisations play an important role in contributing to that objective through appropriate approaches to major safety issues as part of their assessments and research activities. The challenges to nuclear safety are international. Changes in underlying technologies such as instrumentation and control, the impact of electricity market deregulation, demands for improved safety and safety management, the ageing of nuclear facilities, waste management, maintaining and improving scientific and technical knowledge, and the need for greater transparency - these are all issues where the value of an international approach is gaining

  1. EUROSAFE Forum for nuclear safety. Towards Convergence of Technical Nuclear Safety Practices in Europe. Safety Improvements - Reasons, Strategies, Implementation

    International Nuclear Information System (INIS)

    The EUROSAFE Forum for Nuclear Safety is part of the EUROSAFE approach, which consists of two further elements: the EUROSAFE Tribune and the EUROSAFE Web site. The general aim of EUROSAFE is to contribute to fostering the convergence of technical nuclear safety practices in a broad European context. This is done by providing technical safety and research organisations, safety authorities, power utilities, the rest of the industry and non-governmental organisations mainly from the European Union and East-European countries, and international organisations with a platform for the presentation of recent analyses and R and D in the field of nuclear safety. The goal is to share experiences, to exchange technical and scientific opinions, and to conduct debates on key issues in the fields of nuclear safety and radiation protection. The EUROSAFE Forum on 2005 focused on Safety Improvements, Reasons - Strategies - Implementation, from the point of view of the authorities, TSOs and industry. Latest work in nuclear installation safety and research, waste management, radiation safety as well as nuclear material and nuclear facilities security carried out by GRS, IRSN, AVN and their partners in the European Union, Switzerland and Eastern Europe are presented. A high level of nuclear safety is a priority for the countries of Europe. The technical safety organisations play an important role in contributing to that objective through appropriate approaches to major safety issues as part of their assessments and research activities. The challenges to nuclear safety are international. Changes in underlying technologies such as instrumentation and control, the impact of electricity market deregulation, demands for improved safety and safety management, the ageing of nuclear facilities, waste management, maintaining and improving scientific and technical knowledge, and the need for greater transparency - these are all issues where the value of an international approach is gaining

  2. Induction chemotherapy in technically unresectable locally advanced oral cavity cancers: Does it make a difference?

    Directory of Open Access Journals (Sweden)

    V M Patil

    2013-01-01

    Full Text Available Background: Locally advanced and unresectable oral cavity cancers have a poor prognosis. Induction might be beneficial in this setting by reducing tumor bulk and allowing definitive surgery. Aim: To analyze the impact of induction chemotherapy on locally advanced, technically unresectable oral cavity cancers. Materials and Methods: Retrospective analysis of patients with locally advanced oral cavity cancers, who were treated with neoadjuvant chemotherapy (NACT during the period between June 2009 and December 2010. Data from a prospectively filled database were analyzed for information on patient characteristics, chemotherapy received, toxicity, response rates, local treatment offered, patterns of failure, and overall survival. The statistical analysis was performed with SPSS version 16. Results: 123 patients, with a median age of 42 years were analyzed. Buccal mucosa was the most common subsite (68.30%. Three drug regimen was utilized in 26 patients (21.10% and the rest received two drug regimen. Resectability was achieved in 17 patients treated with 3 drug regimen (68.00% and 36 patients receiving 2 drug regimen. Febrile neutropenia was seen in 3 patients (3.09% receiving 2 drug regimen and in 9 patients (34.62% receiving 3 drug regimen. The estimated median OS was not reached in patients who had clinical response and underwent surgery as opposed to 8 months in patients treated with non-surgical modality post NACT (P = 0.0001. Conclusion: Induction chemotherapy was effective in converting technically unresectable oral cavity cancers to operable disease in approximately 40% of patients and was associated with significantly improved overall survival in comparison to nonsurgical treatment.

  3. Planning and implementation of Istanbul Technical University TRIGA research reactor program

    International Nuclear Information System (INIS)

    The Istanbul Technical University TRIGA Research Reactor at the Institute for Nuclear Energy, which went critical on March 11, 1979 is basically a pulsing type TRIGA Mark - II reactor. Completion of the ITU-TRR contributed to broaden the role of the Institute for Nuclear Energy of the Technical University in Istanbul in the nuclear field by providing for the first time adequate on-campus experimental facilities for nuclear engineering studies to ITU students. The research program which is currently under planning at ITU-NEE encompasses: a) Neutron activation analysis studies by techniques and applications to chemistry, mining, materials research, archaeological and biomedical studies; b) applications of Radioisotopes; c) Radiography with reactor neutron beams; d) Radiation Pulsing

  4. Considerations for Implementation of Cancer Molecular Diagnostics Into Clinical Care.

    Science.gov (United States)

    Hayes, Daniel F

    2016-01-01

    Physicians have provided personalized care with as much precision as possible for several centuries. However, increasingly sophisticated understanding of the human genome and of cancer biology has permitted identification of genetic and phenotypic distinctions that might permit development of new tumor biomarker tests for risk categorization, screening, differential diagnosis, prognosis, prediction, and monitoring. Both commercial and academic laboratories are offering tests for single analytes, panels of tests of single analytes, multiparameter assays coalesced into a signature, and total genomic, transcriptomic, or proteomic analyses. However, the absence of a consistent regulatory environment has led to marketing of assays without proven analytic validity or clinical utility. U.S. Food and Drug Administration (FDA) approval or clearance does not necessarily imply that use of the test will improve patient outcomes, and FDA discretion to permit laboratory-developed tests results in unknown benefit, or harm, of others. In this regard, a "bad tumor marker is as bad as a bad drug." Caveat emptor is not a satisfactory approach to delivering high-quality care. Rather, adoption of tumor biomarker tests should be based on high levels of evidence generated in scientifically rigorous studies that demonstrate both analytical validity and clinical utility. Doing so will ensure that clinicians and patients are confident that a tumor biomarker test is likely to improve their outcomes. PMID:27249708

  5. Moving from Theory to Practice: Implementing the Kin Keeper[superscript SM] Cancer Prevention Model

    Science.gov (United States)

    Williams, K. P.; Mullan, P. B.; Todem, D.

    2009-01-01

    This paper presents the rationale and findings of a feasibility and process study of the Kin Keeper[superscript SM] Cancer Prevention Intervention. An observational cohort study design was implemented with African-American women in synergistic female family relationships. Community health workers (CHWs) from two Michigan public health programs…

  6. Effective interventions to facilitate the uptake of breast, cervical and colorectal cancer screening: an implementation guideline

    Science.gov (United States)

    2011-01-01

    Background Appropriate screening may reduce the mortality and morbidity of colorectal, breast, and cervical cancers. Several high-quality systematic reviews and practice guidelines exist to inform the most effective screening options. However, effective implementation strategies are warranted if the full benefits of screening are to be realized. We developed an implementation guideline to answer the question: What interventions have been shown to increase the uptake of cancer screening by individuals, specifically for breast, cervical, and colorectal cancers? Methods A guideline panel was established as part of Cancer Care Ontario's Program in Evidence-based Care, and a systematic review of the published literature was conducted. It yielded three foundational systematic reviews and an existing guidance document. We conducted updates of these reviews and searched the literature published between 2004 and 2010. A draft guideline was written that went through two rounds of review. Revisions were made resulting in a final set of guideline recommendations. Results Sixty-six new studies reflecting 74 comparisons met eligibility criteria. They were generally of poor to moderate quality. Using these and the foundational documents, the panel developed a draft guideline. The draft report was well received in the two rounds of review with mean quality scores above four (on a five-point scale) for each of the items. For most of the interventions considered, there was insufficient evidence to support or refute their effectiveness. However, client reminders, reduction of structural barriers, and provision of provider assessment and feedback were recommended interventions to increase screening for at least two of three cancer sites studied. The final guidelines also provide advice on how the recommendations can be used and future areas for research. Conclusion Using established guideline development methodologies and the AGREE II as our methodological frameworks, we developed an

  7. Effective interventions to facilitate the uptake of breast, cervical and colorectal cancer screening: an implementation guideline

    Directory of Open Access Journals (Sweden)

    Brouwers Melissa C

    2011-09-01

    Full Text Available Abstract Background Appropriate screening may reduce the mortality and morbidity of colorectal, breast, and cervical cancers. Several high-quality systematic reviews and practice guidelines exist to inform the most effective screening options. However, effective implementation strategies are warranted if the full benefits of screening are to be realized. We developed an implementation guideline to answer the question: What interventions have been shown to increase the uptake of cancer screening by individuals, specifically for breast, cervical, and colorectal cancers? Methods A guideline panel was established as part of Cancer Care Ontario's Program in Evidence-based Care, and a systematic review of the published literature was conducted. It yielded three foundational systematic reviews and an existing guidance document. We conducted updates of these reviews and searched the literature published between 2004 and 2010. A draft guideline was written that went through two rounds of review. Revisions were made resulting in a final set of guideline recommendations. Results Sixty-six new studies reflecting 74 comparisons met eligibility criteria. They were generally of poor to moderate quality. Using these and the foundational documents, the panel developed a draft guideline. The draft report was well received in the two rounds of review with mean quality scores above four (on a five-point scale for each of the items. For most of the interventions considered, there was insufficient evidence to support or refute their effectiveness. However, client reminders, reduction of structural barriers, and provision of provider assessment and feedback were recommended interventions to increase screening for at least two of three cancer sites studied. The final guidelines also provide advice on how the recommendations can be used and future areas for research. Conclusion Using established guideline development methodologies and the AGREE II as our methodological

  8. Performance of Implementing Guideline Driven Cervical Cancer Screening Measures in an Inner City Hospital System

    Science.gov (United States)

    Wieland, Daryl L.; Reimers, Laura L.; Wu, Eijean; Nathan, Lisa M.; Gruenberg, Tammy; Abadi, Maria; Einstein, Mark H.

    2013-01-01

    Objective In 2006, the American Society for Colposcopy and Cervical Pathology (ASCCP) updated evidence based guidelines recommending screening intervals for women with abnormal cervical cytology. In our low-income inner city population, we sought to improve performance by uniformly applying the guidelines to all patients. We report the prospective performance of a comprehensive tracking, evidence-based algorithmically driven call-back and appointment scheduling system for cervical cancer screening in a resource-limited inner city population. Materials and Methods Outreach efforts were formalized with algorithm-based protocols for triage to colposcopy, with universal adherence to evidence-based guidelines. During implementation from August 2006 through July 2008, we prospectively tracked performance using the electronic medical record with administrative and pathology reports to determine performance variables such as the total number of Pap tests, colposcopy visits, and the distribution of abnormal cytology and histology results, including all CIN 2,3 diagnoses. Results 86,257 gynecologic visits and 41,527 Pap tests were performed system-wide during this period of widespread and uniform implementation of standard cervical cancer screening guidelines. The number of Pap tests performed per month varied little. The incidence of CIN 1 significantly decreased from 117/171 (68.4%) the first tracked month to 52/95 (54.7%) the last tracked month (p=0.04). The monthly incidence rate of CIN 2,3, including incident cervical cancers did not change. The total number of colposcopy visits declined, resulting in a 50% decrease in costs related to colposcopy services and approximately a 12% decrease in costs related to excisional biopsies. Conclusions Adherence to cervical cancer screening guidelines reduced the number of unnecessary colposcopies without increasing numbers of potentially missed CIN 2,3 lesions, including cervical cancer. Uniform implementation of administrative

  9. Challenges in the development and implementation of the National Comprehensive Cancer Control Program in Mexico.

    Science.gov (United States)

    Reynoso-Noverón, Nancy; Meneses-García, Abelardo; Erazo-Valle, Aura; Escudero-de Los Ríos, Pedro; Kuri-Morales, Pablo Antonio; Mohar-Betancourt, Alejandro

    2016-04-01

    Chronic noncommunicable diseases (NCDs), including cancer, have become the leading cause of human morbidity and mortality. In Mexico, cancer is the third leading cause of death, with a high incidence among the economically active population, a high proportion of advanced stages at diagnosis and limited care coverage for patients. However, no public policy aimed at managing this important public health problem has been developed and implemented to date. This manuscript describes the first interinstitutional proposal of a National Program for Cancer Control, considering the known risk factors, early detection, treatment, palliative care and patient rehabilitation. This manuscript also outlines a series of thoughts on the difficulties and needs that the Mexican health system faces in achieving the main objectives of the program: to decrease the incidence of cancer, to increase survival and to improve the quality of life for this group of patients. PMID:27557393

  10. Implementing the American Cancer Society breast cancer awareness program in the workplace.

    Science.gov (United States)

    Culver, J; Alexander, E J

    1989-05-01

    1. The goal of the American Cancer Society and of the National Cancer Institute is to increase the survival of women with breast cancer through early detection. 2. The key ingredients in promoting any program are enthusiasm and a rationale that identifies need, cost-containment, and program responsibility. 3. Utilizing nursing skills that allay fears but encourage thorough evaluation, engenders confidence in the department and the program. 4. Employees have more confidence in a program when results are communicated, and administrative support is more likely when justification is documented. PMID:2712881

  11. OPERATION OF ENTERPRISE RESOURCE PLANNING SYSTEM IMPLEMENTATION COMPATIBILITY TOWARDS TECHNICAL ADVANCEMENT

    Directory of Open Access Journals (Sweden)

    J. Venkatesh

    2013-01-01

    Full Text Available The Execution of ERP systems has been perplexing factor for many firms. Many establishments have accepted that the operation of ERP system is a massive hindrance until the flow of process is organized carefully. As information technology is booming its prerequisite for organizations to realize the prominence of technical advancement and compatibility in work environment. A complete review was done to ascertain the features and strategic aids of ERP enactments using the retorts from 120 firms. The respondents were approached with orderly framed questionnaires, thereby giving them ample time to come out with their own thoughts. The effects of this learning provide assistance for the vendors, higher officials and ERP specialists to be more competent in handling the execution of ERP with their inadequate possessions there by augmenting the business. It acts a pathway for the concerns to realize their potent and extend their business platform.

  12. Implementation of burnup credit in spent fuel management systems. Proceedings of a technical committee meeting

    International Nuclear Information System (INIS)

    The purpose of this Technical Committee Meeting was to explore the status of international activities related to the use of burnup credit for spent fuel applications. This was the second major meeting on the issues of burnup credit for spent fuel management systems held since the IAEA began to monitor the uses of burnup credit in spent fuel management systems in 1997. Burnup credit for wet and dry storage systems is needed in many Member States to allow for increased initial fuel enrichment, and to increase the storage capacity and thus to avoid the need for extensive modifications of the spent fuel management systems involved. This document contains 31 individual papers presented at the Meeting; each of the papers was indexed separately

  13. Open Access progress at CERN: technical implementation [OA Progress at CERN, Switzerland

    OpenAIRE

    Pepe, Alberto

    2005-01-01

    CERN has pursued open dissemination of scientific results since its early beginnings. CERN Document Server (CDS) today offers access to over 750,000 bibliographic records, including 320,000 fulltext documents, of interest to people working in particle physics and related areas. Covers preprints, articles, books, journals, photographs, and much more. Speech made at the conference session 'Reports from delegates on implementing the Berlin Declaration in their organisations'.

  14. Assessment of required resources for implementation of national breast cancer screening program in Serbia

    Directory of Open Access Journals (Sweden)

    Majstorović Nemanja

    2014-01-01

    Full Text Available Introduction. High values of standardized mortality and morbidity rates of standardized cancer mortality in Serbia, especially colorectal, cervical and breast cancer led to creation of national programs for their early detection and engagement of the international support for their implementation. Objective. Assessment of required resources (time, personnel, financial to implement the National program for screening of breast cancer in the Republic of Serbia. Methods. Three possible scenarios have been prepared (optimistic, realistic and pessimistic based on the expected coverage by screening of women aged 45 to 69 years, and time, personnel and financial feasibility estimates were made for a two-year screening cycle. Results. Time aspect of feasibility even under conditions of “relaxation” of the assumption on the number of working days during the year did not question feasibility of any of the scenarios. Personnel feasibility is only possible in the pessimistic scenario, while the financial feasibility only makes sense in optimistic scenario as the least unfavorable solution due to economies of scale. Conclusion. Establishment of the initial base of skilled radiologists and radiology technicians and the system for their continuous medical education as well as allocation of specific MoH budget line for screening program expenditures, along with donated mammographs and good organization and coordination, may provide unobstructed implementation of the National program for early detection of breast cancer in the Republic of Serbia.

  15. Pre-visualization of the biogas compost in rural area : Final Report of Technical Implementation

    International Nuclear Information System (INIS)

    Biogas-Compost Technology is being experimented in several research centers in Burkina Faso. This technology is about putting up prototypes in order to allow the use of fermentation products. Research on how to operate such technology, no matter small irrigation or domestic energy, has enabled the evaluation of the biogas-compost production and consumption. The implementation of such technology has made possible the agronomic valorization of fermentation residues, the improvement of the process of gas production, and the decrease of installation costs

  16. Technical and organisational aspects in enterprise resource planning systems implementation: lessons from a Spanish public hospital

    Science.gov (United States)

    Escobar-Rodriguez, Tomas; Escobar-Pérez, Bernabe; Monge-Lozano, Pedro

    2014-09-01

    Public resources should always be managed efficiently, more so in times of crisis. Due to the specific characteristics of the healthcare sector, there is a need for special attention, especially in regards to hospitals. Administrators need useful tools to be able to efficiently manage available resources, such as enterprise resource planning (ERP) systems. Therefore, an analysis of the effects of their implementation and use in hospitals is valuable. This study has two purposes. One is to analyse the role ERP systems play in aiding the integration of hospital data, with focus on user satisfaction as well as possible resistance to change. The other purpose is to analyse the effects of implanting and using ERP systems in the hospital environment and identifying how certain variables influence the process, especially the existence of different organisational cultures. Results indicate that clinical information has become notably more integrated, despite the lack of flow in the economic-financial area. The heterogeneous nature of the different groups, clinical (Medical, Nursing) and non-clinical (Economic-Financial, Accounting), had a negative influence on the implementation process, and limited the integration of information as well as the system's performance.

  17. Technical report on implementation of reactor internal 3D modeling and visual database system

    International Nuclear Information System (INIS)

    In this report was described a prototype of reactor internal 3D modeling and VDB system for NSSS design quality improvement. For improving NSSS design quality several cases of the nuclear developed nation's integrated computer aided engineering system, such as Mitsubishi's NUWINGS (Japan), AECL's CANDID (Canada) and Duke Power's PASCE (USA) were studied. On the basis of these studies the strategy for NSSS design improvement system was extracted and detail work scope was implemented as follows : 3D modelling of the reactor internals were implemented by using the parametric solid modeler, a prototype system of design document computerization and database was suggested, and walk-through simulation integrated with 3D modeling and VDB was accomplished. Major effects of NSSS design quality improvement system by using 3D modeling and VDB are the plant design optimization by simulation, improving the reliability through the single design database system and engineering cost reduction by improving productivity and efficiency. For applying the VDB to full scope of NSSS system design, 3D modelings of reactor coolant system and nuclear fuel assembly and fuel rod were attached as appendix. 2 tabs., 31 figs., 7 refs. (Author) .new

  18. Design, Implementation and Analysis of Learner-Centered Guided In-Service Programme for Technical Teacher Education

    Directory of Open Access Journals (Sweden)

    Tiia Rüütmann

    2014-03-01

    Full Text Available The design of learner-centered guided in-service program for technical teacher education has been launched at Estonian Centre for Engineering Pedagogy at Tallinn University of Technology. The aim of the program has been facilitating the initial in-service teaching experience, involving mentoring, peer support and cognitive apprenticeship. The emphasis has been on teaching for knowledge application, including the choice of content and processes, motivation, reflection, problem-solving, choice of educational technology, effective teaching methods, teaching models and strategies ཿ concepts, tools and procedures of the field of engineering, organized in ways enabling teachers to formulate real world problems, apply and solve them. The program has been implemented since 2012 and covers IGIP curriculum requirements. In the present article the designed program is described and analyzed.

  19. Auxiliary energy in building technical services - Potential for savings and ways toward implementation; Hilfsenergie Haustechnik: Einspar-Potenziale und Umsetzungspfade

    Energy Technology Data Exchange (ETDEWEB)

    Nipkow, J. [Schweizerische Agentur fuer Energieeffizienz (SAFE), Zuerich (Switzerland); Peters, M.; Wapf, B. [Econcept AG, Zuerich (Switzerland)

    2006-11-15

    This report for the Swiss Federal Office of Energy (SFOE) examines the potential available for saving energy in the building technical services area. Savings of six to eight percent are noted for the area concerning pumps, fans, control systems, etc. The report presents the aims of the project and reviews the definition of auxiliary energy. National and international energy labels, limiting values and typical values for efficiency are examined. The results of surveys are presented and discussed as are the opinions and suggestions of planners, installers and architects. Manufacturers' opinions and marketing aspects are briefly examined, as are energy labels and regulations. Implementation of measures in various areas are described. Economical aspects and actions to be taken are discussed and educational measures are looked at. Follow-up projects are defined.

  20. Technical progress, the concept of individualized cancer treatment and the innovation of computer-assisted radiotherapy planning

    International Nuclear Information System (INIS)

    After a first step of cancerogenesis, the further development of the tumor is an individual process. At the end of this process the tumor is formed as an individual in the individual. The individuality of cancer exists on the level of organs, tissues and cells and includes an individual tumor-host relationship. Today, optimized cancer treatment requires a most precise biological characterization possible of the tumor and of the tumor-host relationship, which will provide objective information about the individual character of every tumor. Routine analysis and strict therapeutic consideration of the clinical and biological individuality of human cancer can offer real chances for the improvement of cancer treatment. A routine acquisition of individual tumor characteristics will be possible only if methods and equipment are available for the registration of suitable parameters. In this context technical innovations have an essential influence on the realization of the concept of individualized cancer treatment. With the method of flow cytophotometry and other techniques examples are given in how far the ideas of individual cancer management can be realized by introduction of new technical solutions into medical research and clinical practice. Unfortunately there is still a lack of methodology in individualizing cancer treatment. The individualization of radiotherapy is connected to an extremely high degree of technical innovations. Particularly this refers to the topometrical description of the target volume in relation to the adjacent anatomical structures and the body contour as well as the fitting of isodoses to the shape and size of the target volume. As an example of innovation of a technical solution for individual radiotherapy planning the computer-assisted radiotherapy planning system DOPSY is described. (author)

  1. Implementation of the European protocol for quality control of the technical aspects of mammography screening in Bulgaria

    International Nuclear Information System (INIS)

    The results from the national pilot project on implementation of the European protocol for the quality control (QC) of the technical aspects of mammography screening as well as the European protocol for dosimetry in mammography in Bulgaria are presented. A QC programme for mammography equipment and a standardised measurement protocol were created. The full QC programme was tested on four mammography units of different types and ages. A national survey was performed for entrance surface air kerma (ESAK) on 20 units using a 45 mm PMMA standard phantom. Average glandular dose (AGD) was calculated using the conversion coefficients from the European dosimetry protocol. The survey demonstrated considerable differences in the technical condition of the mammography units that resulted in varying image quality. The measured values of ESAK showed significant variations. Doses for ∼45% of the units were found to be below the European reference level. The values for AGD ranged from 0.35 to 3.47 mGy. The main problems found were film processing, optical density (OD) control settings and AEC adjustment. The results showed the importance of film OD measurements parallel to dose measurements. The X-ray mammography in the country needs optimisation. Comprehensive quality assurance programme should be adopted in all departments covering permanent QC of the equipment, image quality and breast dose. (authors)

  2. Implementing Case Management in New York State’s Partnerships for Publicly Funded Breast Cancer Screening

    Directory of Open Access Journals (Sweden)

    Patricia P. Lillquist, PhD, MSW

    2008-04-01

    Full Text Available IntroductionThis research aimed to explore differences in the implementation of case management among local breast cancer screening partnerships in New York State after changes in federal public policy in 1998 and to achieve a better understanding of case management in a new and distinct practice setting. Capacity and willingness to implement change were theorized to explain local differences in implementation. Local breast cancer screening programs that received federal funding through the New York State Department of Health were invited to participate in the study.MethodsA mail survey was administered to the directors of New York’s 53 local breast cancer screening partnerships in 2003. The survey included questions about willingness and capacity to implement case management and a scale to assess case management program philosophy. Factor analysis and correlations were used to compare willingness and capacity with differences in implementation.ResultsTwo common factors — task focus and self-identity focus — were identified as factors that differentiated case management programs. Task-focus partnerships undertook a broader range of tasks but were less likely to report autonomy in making program changes. Self-identity partnerships were less likely to report difficulties with other agencies and scored highly on innovation, involvement in work, and interest in client service. Having a nurse as the case manager, being aware of the standards of case management, and providing health education were associated with both task focus and self-identity focus.ConclusionThe study identified distinct styles of implementation. These styles have implications for the breadth of services provided, such as whether client-level services only are offered. Interagency coordination was facilitated in partnerships with comprehensive case management.

  3. [BENEFITS AND RISKS AT IMPLEMENTATION OF PROPHILACTIC VACCINES FOR CERVICAL CANCER].

    Science.gov (United States)

    Zlatkov, V; Kostova, P

    2016-01-01

    The aim of this review is to present the benefits and risks of the implementation of prophylactic vaccines for cervical cancer. The classical understanding of human papilloma virus (HPV) infection and its role for the cervical oncogenesis, as well as, the place of prophylactic HPV vaccines are discussed. Results concerning the effectiveness of vaccines 10 years after their introduction and data about their safety are presented. Reports of the use in practice of the new 9-valent HPV vaccine and the first results of its implementation are studied. PMID:27514142

  4. [Technical novelties, latest diagnostic options in the MRI and CT diagnostics of colorectal cancer].

    Science.gov (United States)

    Jederán, Éva; Gõdény, Mária

    2015-09-01

    Diagnostic and therapeutic options of colorectal cancer (CRC) have changed over the past decade. Imaging plays a major role, thus the use of scanning methods is recommended by guidelines. Accurate staging, evaluation of treatment efficacy and identification of residual and recurrent tumors are required for the modern management of colorectal cancer. If adequate technical background is provided, magnetic resonance imaging (MRI) gives the information upon which therapeutic options may be determined. High-resolution MRI scans can be interpreted as maps providing functional and molecular information. Diffusion-weighted MRI (DW-MRI) has shown promising results regarding the determination of tumor volume and evaluation of treatment efficacy. Perfusion dynamic contrast-enhanced MRI (P-DCE-MRI) is the subject of research in the early assessment of treatment efficacy. Magnetic resonance spectroscopic imaging (MRSI) is a procedure utilizing biochemical analysis. Its application in CRC is under investigation. Clinical effectiveness of PET-MRI (hardware-based combination of MRI and positron emission tomography) is also being studied. Diagnostic value of computed tomographic colonography (CTC) has been proven in the detection of CRC as well as of polyps. PMID:26339907

  5. Preformulated Implementation Intentions to Promote Colorectal Cancer Screening: A Cluster-Randomized Trial

    OpenAIRE

    Lo, S. H.; Good, A; Sheeran, P.; G. Baio; Rainbow, S; Vart, G.; von Wagner, C

    2013-01-01

    Objective: To evaluate an intervention based on implementation intention principles designed to increase uptake of colorectal cancer screening, and to examine differential efficacy by socioeconomic deprivation. Method: In England, adults aged between 60 and 69 years are invited for biennial fecal occult blood testing. A test kit and an information leaflet are mailed to each individual by the "Hubs" that deliver the national screening program. In the intervention group, three preformulated imp...

  6. Technical Considerations for the Generation of Adoptively Transferred T Cells in Cancer Immunotherapy

    Directory of Open Access Journals (Sweden)

    Anthony Visioni

    2016-09-01

    Full Text Available A significant function of the immune system is the surveillance and elimination of aberrant cells that give rise to cancer. Even when tumors are well established and metastatic, immune-mediated spontaneous regressions have been documented. While there are have been various forms of immunotherapy, one of the most widely studied for almost 40 years is adoptive cellular immunotherapy, but its success has yet to be fully realized. Adoptive cell transfer (ACT is a therapeutic modality that has intrigued physicians and researchers for its many theoretical benefits. Preclinical investigations and human trials have utilized natural killer (NK cells, dendritic cells (DC, macrophages, T-cells or B-cells for ACT with the most intense research focused on T-cell ACT. T-cells are exquisitely specific to the target of its T-cell receptor (TCR, thus potentially reducing the amount of collateral damage and off-target effects from treatment. T-cells also possess a memory subset that may reduce the risk of recurrence of a cancer after the successful treatment of the primary disease. There are several options for the source of T-cells used in the generation of cells for ACT. Perhaps the most widely known source is T-cells generated from tumor-infiltrating lymphocytes (TILs. However, studies have also employed peripheral blood mononuclear cells (PBMCs, lymph nodes, and even induced pluripotent stem cells (IPSCs as a source of T-cells. Several important technical considerations exist regarding benefits and limitations of each source of T-cells. Unique aspects of T-cells factor into their ability to be efficacious in ACT including the total number of cells available for ACT, the anti-tumor efficacy on a per cell basis, the repertoire of TCRs specific to tumor cells, and their ability to traffic to various organs that harbor tumor. Current research is attempting to unlock the full potential of these cells to effectively and safely treat cancer.

  7. Socio-technical and organizational challenges to wider e-Health implementation.

    Science.gov (United States)

    Vitacca, M; Mazzù, M; Scalvini, S

    2009-01-01

    Recent advances in information communication technology allow contact with patients at home through e-Health services (telemedicine, in particular). We provide insights on the state of the art of e-Health and telemedicine for possible wider future clinical use. Telemedicine opportunities are summarized as i) home telenursing, ii) electronic transfer to specialists and hospitals, iii) teleconsulting between general practitioners and specialists and iv) call centres activities and online health. At present, a priority action of the EU is the Initiative on TM for chronic disease management as home health monitoring and the future Vision for Europe 2020 is based on development of Integrated Telemedicine Services. There are pros and cons in e-Health and telemedicine. Benefits can be classified as benefits for i) citizens, patients and caregivers and ii) health care provider organizations. Institutions and individuals that play key roles in the future of e-Health are doctors, patients and hospitals, while the whole system should be improved at three crucial levels: 1) organizational, 2) regulatory and 3) technological. Quality, access and efficiency are the general key issues for the success of e-Health and telemedicine implementation. The real technology is the human resource available into the organizations. For e-Health and telemedicine to grow, it will be necessary to investigate their long-term efficacy, cost effectiveness, possible improvement in quality of life and impact on public health burden.

  8. Development And Implementation Of A Strategic Technical Baseline Approach For Nuclear Decommissioning And Clean Up Programmes In The UK

    International Nuclear Information System (INIS)

    The NDA mission as set out within the Energy Act 2004 and stated in the NDA strategy is clear: - 'to deliver a world class programme of safe, cost-effective, accelerated and environmentally responsible decommissioning of the UK's civil nuclear legacy in an open and transparent manner and with due regard to the socio-economic impacts on our communities. Critical to achieving the NDA main objective and overall mission is to accelerate and deliver clean-up programmes through the application of appropriate and innovative technology. The NDA remit also requires us to secure good practice by contractors and carry out and promote research into matters relating to the decommissioning and clean up of nuclear installations and sites. NDA have defined a strategic approach for the underpinning of operational and decommissioning activities where each nuclear site is required to write within the Life Time Plans (LTP) the proposed technical baseline for those activities. This enables the robustness of the activities to be assessed, the gaps and opportunities and accompanying Research and Developments (R and D) requirements to be highlighted and investment to be targeted at key technical issues. NDA also supports the development of a commercial framework where innovation is encouraged and improvements can be demonstrated against the technical baseline. In this paper we will present NDA's overall strategic approach, the benefits already realised and highlight the areas for continued development. In conclusion: The development and implementation of a strategic approach to robustly underpin the technical components of the lifetime plans for operational and decommissioning activities on NDA sites has been extremely successful. As well as showing how mature technology assumptions are and where the key gaps and risks are it has also provided a method for highlighting opportunities to improve on that baseline. The use of a common template across all NDA LTPs has enabled direct comparison

  9. Implementing rapid, robust, cost-effective, patient-centred, routine genetic testing in ovarian cancer patients.

    Science.gov (United States)

    George, Angela; Riddell, Daniel; Seal, Sheila; Talukdar, Sabrina; Mahamdallie, Shazia; Ruark, Elise; Cloke, Victoria; Slade, Ingrid; Kemp, Zoe; Gore, Martin; Strydom, Ann; Banerjee, Susana; Hanson, Helen; Rahman, Nazneen

    2016-01-01

    Advances in DNA sequencing have made genetic testing fast and affordable, but limitations of testing processes are impeding realisation of patient benefits. Ovarian cancer exemplifies the potential value of genetic testing and the shortcomings of current pathways to access testing. Approximately 15% of ovarian cancer patients have a germline BRCA1 or BRCA2 mutation which has substantial implications for their personal management and that of their relatives. Unfortunately, in most countries, routine implementation of BRCA testing for ovarian cancer patients has been inconsistent and largely unsuccessful. We developed a rapid, robust, mainstream genetic testing pathway in which testing is undertaken by the trained cancer team with cascade testing to relatives performed by the genetics team. 207 women with ovarian cancer were offered testing through the mainstream pathway. All accepted. 33 (16%) had a BRCA mutation. The result informed management of 79% (121/154) women with active disease. Patient and clinician feedback was very positive. The pathway offers a 4-fold reduction in time and 13-fold reduction in resource requirement compared to the conventional testing pathway. The mainstream genetic testing pathway we present is effective, efficient and patient-centred. It can deliver rapid, robust, large-scale, cost-effective genetic testing of BRCA1 and BRCA2 and may serve as an exemplar for other genes and other diseases. PMID:27406733

  10. Implementing rapid, robust, cost-effective, patient-centred, routine genetic testing in ovarian cancer patients.

    Science.gov (United States)

    George, Angela; Riddell, Daniel; Seal, Sheila; Talukdar, Sabrina; Mahamdallie, Shazia; Ruark, Elise; Cloke, Victoria; Slade, Ingrid; Kemp, Zoe; Gore, Martin; Strydom, Ann; Banerjee, Susana; Hanson, Helen; Rahman, Nazneen

    2016-07-13

    Advances in DNA sequencing have made genetic testing fast and affordable, but limitations of testing processes are impeding realisation of patient benefits. Ovarian cancer exemplifies the potential value of genetic testing and the shortcomings of current pathways to access testing. Approximately 15% of ovarian cancer patients have a germline BRCA1 or BRCA2 mutation which has substantial implications for their personal management and that of their relatives. Unfortunately, in most countries, routine implementation of BRCA testing for ovarian cancer patients has been inconsistent and largely unsuccessful. We developed a rapid, robust, mainstream genetic testing pathway in which testing is undertaken by the trained cancer team with cascade testing to relatives performed by the genetics team. 207 women with ovarian cancer were offered testing through the mainstream pathway. All accepted. 33 (16%) had a BRCA mutation. The result informed management of 79% (121/154) women with active disease. Patient and clinician feedback was very positive. The pathway offers a 4-fold reduction in time and 13-fold reduction in resource requirement compared to the conventional testing pathway. The mainstream genetic testing pathway we present is effective, efficient and patient-centred. It can deliver rapid, robust, large-scale, cost-effective genetic testing of BRCA1 and BRCA2 and may serve as an exemplar for other genes and other diseases.

  11. Youth Cancer Services in Australia: Development and Implementation. International Perspectives on AYAO, Part 3.

    Science.gov (United States)

    Osborn, Michael; Little, Caroline; Bowering, Sharon; Orme, Lisa

    2013-09-01

    Based on an increased appreciation of the unique challenges facing adolescents and young adults with cancer, there has been a coordinated national effort in Australia in recent years to address this issue. In 2007, CanTeen, a consumer support organization for young people with cancer, partnered with the Australian federal government to fund the development of a network of multidisciplinary Youth Cancer Services across the country. This has resulted in a collaborative effort involving clinicians, the federal and state governments, consumers, CanTeen, and other non-government organizations to implement equitable and sustainable models of care that will improve the coordination of services, treatment, and support for 15-25-year-olds with cancer. The aims of this article are to outline the origins of Youth Cancer Services in Australia, to discuss several innovative models of care that have developed according to local geographic and demographic need, to highlight some successful strategies and early obstacles to service development, and to outline the challenges for the future.

  12. New technical knowledge to be implemented to the revision of rules on pipe wall thinning management for PWR Plants. 2006 edition

    International Nuclear Information System (INIS)

    Rules for PWR plant pipe wall thinning management were formulated by the Japan Society of Mechanical Engineers in 2006. Since then thinning management of Japanese PWR plants has been carried out based on this rule. Pipe wall thinning phenomena to be dealt with in this rule have been identified in many piping components of power plants. New technical knowledge has been accumulated since the issuance of 2006 edition. We have formulated these knowledge and information about the thinning phenomena in PWR power plants. Given the history of application of this rule, we have to make our best effort to carry out a study of latest technical knowledge and implement them to the revision of rule and improve pipe wall thinning management. This paper summarizes the new technical knowledge and basis to be implemented to the revision of rules on pipe wall thinning management for PWR plants in Japan. (author)

  13. Implementing Selective Waste Collection: The Articulation between Pedagogical Theory and Practice in the Pollution and Ecology Class in the Environmental Control Technical Course

    Science.gov (United States)

    Rocas, Giselle; Gonzalez, Wania R. Coutinho; Araujo, Flavia Monteiro de Barros

    2009-01-01

    This study focuses on the implementation of selective waste collection in a school located on the outskirts of the city of Rio de Janeiro. The participants consisted mainly of 64 students taking an Environmental Control technical course during 2007 and 2008. By addressing selective waste collection, the pedagogical proposal aimed at: a) enabling…

  14. Patients’ opinions on quality of care before and after implementation of a short stay programme following breast cancer surgery.

    NARCIS (Netherlands)

    Kok, M. de; Weijden, T. van der; Kessels, A.G.H.; Dirksen, C.D.; Sixma, H.J.M.; Velde, C.J.H. van de; Roukema, J.A.; Finaly-Marais, C.; Ent, F.W.C. van der; Meyenfeldt, M.F. von

    2010-01-01

    PURPOSE: To assess breast cancer patients' opinions on quality of care during an implementation study on short hospital stay, and to formulate patient inspired targets for further quality improvement based on results of the QUOTE (Quality of Care Through the Patients' Eyes) breast cancer instrument.

  15. Implementing women's cancer screening programs in American Indian and Alaska Native populations.

    Science.gov (United States)

    Lantz, Paula M; Orians, Carlyn E; Liebow, Edward; Joe, Jennie R; Burhansstipanov, Linda; Erb, Julie; Kenyon, Kathryn

    2003-01-01

    The National Breast and Cervical Cancer Early Detection Program provides funding to tribes and tribal organizations to implement comprehensive cancer screening programs using a program model developed for state health departments. We conducted a multiple-site case study using a participatory research process to describe how 5 tribal programs implemented screening services, and to identify strategies used to address challenges in delivering services to American Indian and Alaska Native women. We analyzed data from semistructured interviews with 141 key informants, 16 focus groups with 132 program-eligible women, and program documents. Several challenges regarding the delivery of services were revealed, including implementing screening programs in busy acute-care environments, access to mammography, providing culturally sensitive care, and providing diagnostic/treatment services in rural and remote locations. Strategies perceived as successful in meeting program challenges included identifying a "champion" or main supporter of the program in each clinical setting, using mobile mammography, using female providers, and increasing the capacity to provide diagnostic services at screening sites. The results should be of interest to an international audience, including those who work with health-related programs targeting indigenous women or groups that are marginalized because of culture, geographic isolation, and/or socioeconomic position.

  16. Implementation of intensity-modulated conformational radiotherapy for cervical cancers at the Alexis Vautrin Centre

    International Nuclear Information System (INIS)

    As platinum salt based concomitant conformational radiotherapy and chemotherapy have been used as a standard treatment for cervical cancers but resulted in digestive and haematological toxicities, this research thesis reports the application of intensity-modulated conformational radiation therapy. After having recalled some epidemiological, anatomical aspects, diagnosis and treatments aspects regarding cervical cancer, the author presents this last treatment technique (principles, benefits, practical implementation). The author discusses results obtained by an experiment during which seven patients have been treated by simple conformational radiation therapy, and four by intensity-modulated conformational radiation therapy. Results are discussed in terms of volumes (clinical target volume, growth target volume, planned target volume), dosimetric results, toxicities (urine and skin), weight loss

  17. Molecular profiling of indolent human prostate cancer:tackling technical challenges to achieve high-fidelity genome-wide data

    Institute of Scientific and Technical Information of China (English)

    Thomas A. Dunn; Helen L. Fedor; Angelo M. De Marzo; Jun Luo

    2012-01-01

    The contemporary problem of prostate cancer overtreatment can be partially attributed to the diagnosis of potentially indolent prostate cancers that pose low risk to aged men,and lack of sufficiently accurate risk stratification methods to reliably seek out men with indolent diseases.Since progressive acquisition and accumulation of genomic alterations,both genetic and epigenetic,is a defining feature of all human cancers at different stages of disease progression,it is hypothesized that RNA and DNA alterations characteristic of indolent prostate tumors may be different from those previously characterized in the setting of clinically significant prostate cancer.Approaches capable of detecting such alterations on a genome-wide level are the most promising.Such analysis may uncover molecular events defining early initiating stages along the natural history of prostate cancer progression,and ultimately lead to rational development of risk stratification methods for identification of men who can safely forego treatment.However,defining and characterizing indolent prostate cancer in a clinically relevant context remains a challenge,particularly when genome-wide approaches are employed to profile formalin-fixed paraffin-embedded (FFPE) tissue specimens.Here,we provide the conceptual basis underlying the importance of understanding indolent prostate cancer from molecular profiling studies,identify the key hurdles in sample acquisition and variables that affect molecular data derived from FFPE tissues,and highlight recent progresses in efforts to address these technical challenges.

  18. Managing symptoms during cancer treatments: evaluating the implementation of evidence-informed remote support protocols

    Directory of Open Access Journals (Sweden)

    Stacey Dawn

    2012-11-01

    Full Text Available Abstract Background Management of cancer treatment-related symptoms is an important safety issue given that symptoms can become life-threatening and often occur when patients are at home. With funding from the Canadian Partnership Against Cancer, a pan-Canadian steering committee was established with representation from eight provinces to develop symptom protocols using a rigorous methodology (CAN-IMPLEMENT©. Each protocol is based on a systematic review of the literature to identify relevant clinical practice guidelines. Protocols were validated by cancer nurses from across Canada. The aim of this study is to build an effective and sustainable approach for implementing evidence-informed protocols for nurses to use when providing remote symptom assessment, triage, and guidance in self-management for patients experiencing symptoms while undergoing cancer treatments. Methods A prospective mixed-methods study design will be used. Guided by the Knowledge to Action Framework, the study will involve (a establishing an advisory knowledge user team in each of three targeted settings; (b assessing factors influencing nurses’ use of protocols using interviews/focus groups and a standardized survey instrument; (c adapting protocols for local use, ensuring fidelity of the content; (d selecting intervention strategies to overcome known barriers and implementing the protocols; (e conducting think-aloud usability testing; (f evaluating protocol use and outcomes by conducting an audit of 100 randomly selected charts at each of the three settings; and (g assessing satisfaction with remote support using symptom protocols and change in nurses’ barriers to use using survey instruments. The primary outcome is sustained use of the protocols, defined as use in 75% of the calls. Descriptive analysis will be conducted for the barriers, use of protocols, and chart audit outcomes. Content analysis will be conducted on interviews/focus groups and usability testing

  19. Tolerance and toxicity of neoadjuvant docetaxel, cisplatin and 5 fluorouracil regimen in technically unresectable oral cancer in resource limited rural based tertiary cancer center

    OpenAIRE

    V M Patil; Chakraborty, S; P K Shenoy; A Manuprasad; Sajith Babu, T. P.; T Shivkumar; Babu, S.; A Bhatterjee; S Balasubramanian

    2014-01-01

    Background: Recent studies indicate neoadjuvant chemotherapy (NACT) can result in R0 resection in a substantial proportion of patients with technically unresectable oral cavity cancers. However, data regarding the efficacy and safety of docetaxel, cisplatin and 5 fluorouracil (TPF) NACT in our setting is lacking. The present audit was proposed to evaluate the toxicities encountered during administration of this regimen. It was hypothesized that TPF NACT would be considered feasible for routin...

  20. Effect of implementing a cancer chemotherapy order form on prescribing habits for parenteral antineoplastics.

    Science.gov (United States)

    Pastel, D A; Fay, P; Lee, D

    1993-12-01

    Effect of implementing a cancer chemotherapy order form on prescribing habits for parenteral antineoplastics. The purpose of this study was to determine whether the use of a cancer chemotherapy order form improved prescriber inclusion of necessary prescription information to minimize errors for parenteral antineoplastics when compared to orders written on standard treatment-order forms. Standard treatment order forms and the newly developed chemotherapy order forms were examined for differences in completeness of the following 13 prescription components: diagnosis, height, weight, body surface area, start date and time, dosage (e.g., mg/m2), dose (mg), solution diluent (drips only) and volume (drips only), infusion rate (drips only), route (i.e., IV push or IV drip), frequency of administration, and total number of scheduled doses. The results demonstrate a significant improvement in completeness of necessary prescription information when cancer chemotherapy was ordered by physicians using a chemotherapy order form compared to a standard treatment order form. Importantly, the availability of various prescription components such as height, weight, and dosage may be used by the pharmacist to verify physicians' calculations of body surface area and dose and thereby reduce the chance of serious medication dosage errors. An additional benefit of the new form is a reduction in the time pharmacists spend clarifying orders.

  1. Technical-Oriented Enterprise Resource Planning (ERP) Body of Knowledge for Information Systems Programs: Content and Implementation

    Science.gov (United States)

    Boyle, Todd A.

    2007-01-01

    In this article, the author proposes a body of knowledge that the educators can use to incorporate the technical aspects of enterprise resource planning (ERP) into an information systems (IS) program, encapsulated as the ERP technical knowledge framework. To illustrate the application of this framework, the author discusses a course sequence that…

  2. Planning and implementing an implanted fiducial programme for prostate cancer radiation therapy

    International Nuclear Information System (INIS)

    Full text: Using implanted gold seeds as fiducial markers to verify the position of the prostate in radiation therapy is well accepted and is becoming the standard of practice and requirement for international multicentre trials. In 2006 the decision was made at the Peter MacCallum Caner Centre (Peter Mac) to plan for and implement this process as standard clinical practice for radical dose prostate treatments (74-78 Gy). Before this, programme verification of field placement for prostate cancer radiation treatment was routinely carried out using regular off-line electronic portal imaging with matching of bony anatomy. A small multidisciplinary team investigated and assisted in the implementation of this new practice across the Peter Mac sites at East Melbourne and our three satellite centres. Issues considered included seed size, number and position in the prostate, implant equipment, imaging equipment and procedure and consent and information forms. The use of a custom made fiducial pack, comprehensive patient information and a daily on-line imaging process was implemented. The experience of the first 28 patients at Peter Mac from January 2007 to May 2007 inclusive is reported on.

  3. Technical Problems in Implementing University-Level Computer-Assisted Instruction in Mathematics and Science: First Annual Report. Technical Report No. 293.

    Science.gov (United States)

    Blaine, Lee; And Others

    Difficulties in implementing the EXCHECK/VOCAL System, a general program for mathematics instruction written in the VOCAL language, are presented in terms of informal mathematics procedures, audio and prosodic features, and proposed research. References are appended. (CMV)

  4. First epidemiological analysis of breast cancer incidence and tumor characteristics after implementation of population-based digital mammography screening

    International Nuclear Information System (INIS)

    Purpose: to epidemiologically evaluate the impact of digital mammography screening on incidence rates and tumor characteristics for breast cancer. Materials and methods: the first German digital screening units in the clinical routine were evaluated during the implementation period by using data from the cancer registry to compare the incidence rate of breast cancers and prognostic characteristics. 74% of women aged 50-69 within the region of Muenster/Coesfeld/Warendorf were invited between 10/2005 and 12/2007 for initial screening; 55% participated (n = 35961). Results: in 2002-2004 the average breast cancer incidence rate (per 100000) was 297.9. During the implementation of screening, the rate rose to 532.9 in 2007. Of the 349 cancers detected with screening, 76% (265/349) were invasive compared to 90% (546/608) of cases not detected with screening during the same period. 37% (97/265) of cancers detected in the screening program had a diameter of ≤ 10 mm and 75% (198/265) were node-negative compared to 15% (79/546) and 64% (322/503), respectively, in cancers detected outside the screening program. The distribution of invasive tumor size (pT categories) and the nodal status differed with statistical significance between cancers detected in and outside the program (p = 0.005 and p = 0.004, respectively). (orig.)

  5. Quality assurance for the clinical implementation of kilovoltage intrafraction monitoring for prostate cancer VMAT

    Energy Technology Data Exchange (ETDEWEB)

    Ng, J. A. [School of Medicine, University of Sydney, NSW 2006, Australia and School of Physics, University of Sydney, NSW 2006 (Australia); Booth, J. T. [School of Physics, University of Sydney, NSW 2006, Australia and Northern Sydney Cancer Centre, Royal North Shore Hospital, NSW 2065 (Australia); O’Brien, R. T.; Huang, C.-Y.; Keall, P. J., E-mail: paul.keall@sydney.edu.au [School of Medicine, University of Sydney, NSW 2006 (Australia); Colvill, E. [School of Medicine, University of Sydney, NSW 2006, Australia and Northern Sydney Cancer Centre, Royal North Shore Hospital, NSW 2065 (Australia); Poulsen, P. R. [Department of Oncology, Aarhus University Hospital, Nørrebrogade 44, Aarhus C 8000 (Denmark)

    2014-11-01

    Purpose: Kilovoltage intrafraction monitoring (KIM) is a real-time 3D tumor monitoring system for cancer radiotherapy. KIM uses the commonly available gantry-mounted x-ray imager as input, making this method potentially more widely available than dedicated real-time 3D tumor monitoring systems. KIM is being piloted in a clinical trial for prostate cancer patients treated with VMAT (NCT01742403). The purpose of this work was to develop clinical process and quality assurance (QA) practices for the clinical implementation of KIM. Methods: Informed by and adapting existing guideline documents from other real-time monitoring systems, KIM-specific QA practices were developed. The following five KIM-specific QA tests were included: (1) static localization accuracy, (2) dynamic localization accuracy, (3) treatment interruption accuracy, (4) latency measurement, and (5) clinical conditions accuracy. Tests (1)–(4) were performed using KIM to measure static and representative patient-derived prostate motion trajectories using a 3D programmable motion stage supporting an anthropomorphic phantom with implanted gold markers to represent the clinical treatment scenario. The threshold for system tolerable latency is <1 s. The tolerances for all other tests are that both the mean and standard deviation of the difference between the programmed trajectory and the measured data are <1 mm. The (5) clinical conditions accuracy test compared the KIM measured positions with those measured by kV/megavoltage (MV) triangulation from five treatment fractions acquired in a previous pilot study. Results: For the (1) static localization, (2) dynamic localization, and (3) treatment interruption accuracy tests, the mean and standard deviation of the difference are <1.0 mm. (4) The measured latency is 350 ms. (5) For the tests with previously acquired patient data, the mean and standard deviation of the difference between KIM and kV/MV triangulation are <1.0 mm. Conclusions: Clinical process and

  6. Feasibility and implementation of a literature information management system for human papillomavirus in head and neck cancers with imaging.

    Science.gov (United States)

    Wu, Dee H; Matthiesen, Chance L; Alleman, Anthony M; Fournier, Aaron L; Gunter, Tyler C

    2014-01-01

    This work examines the feasibility and implementation of information service-orientated architecture (ISOA) on an emergent literature domain of human papillomavirus, head and neck cancer, and imaging. From this work, we examine the impact of cancer informatics and generate a full set of summarizing clinical pearls. Additionally, we describe how such an ISOA creates potential benefits in informatics education, enhancing utility for creating enduring digital content in this clinical domain. PMID:25392683

  7. Feasibility and Implementation of a Literature Information Management System for Human Papillomavirus in Head and Neck Cancers with Imaging

    Science.gov (United States)

    Wu, Dee H; Matthiesen, Chance L; Alleman, Anthony M; Fournier, Aaron L; Gunter, Tyler C

    2014-01-01

    This work examines the feasibility and implementation of information service-orientated architecture (ISOA) on an emergent literature domain of human papillomavirus, head and neck cancer, and imaging. From this work, we examine the impact of cancer informatics and generate a full set of summarizing clinical pearls. Additionally, we describe how such an ISOA creates potential benefits in informatics education, enhancing utility for creating enduring digital content in this clinical domain. PMID:25392683

  8. Feasibility and implementation of a literature information management system for human papillomavirus in head and neck cancers with imaging.

    Science.gov (United States)

    Wu, Dee H; Matthiesen, Chance L; Alleman, Anthony M; Fournier, Aaron L; Gunter, Tyler C

    2014-01-01

    This work examines the feasibility and implementation of information service-orientated architecture (ISOA) on an emergent literature domain of human papillomavirus, head and neck cancer, and imaging. From this work, we examine the impact of cancer informatics and generate a full set of summarizing clinical pearls. Additionally, we describe how such an ISOA creates potential benefits in informatics education, enhancing utility for creating enduring digital content in this clinical domain.

  9. Validation and practical implementation of a multidisciplinary cancer distress screening questionnaire

    Energy Technology Data Exchange (ETDEWEB)

    Kirchheiner, K.; Czajka, A.; Komarek, E.; Hohenberg, G.; Poetter, R. [Medical University of Vienna (Austria). Dept. of Radiation Oncology; Ponocny-Seliger, E. [Sigmund Freud Private University, Vienna (Austria). Dept. of Psychology; Doerr, W. [Medical University of Vienna (Austria). Dept. of Radiation Oncology; Medical University of Vienna (Austria). Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology

    2013-07-15

    Background: In order to identify cancer patients with psychosocial needs during radiotherapy, a routine screening questionnaire is widely recommended in the literature. Several tools focusing mainly on psychological issues have been developed during the past decade. However, problems with their implementation into clinical routine have been repeatedly reported, due to a lack of practicability for clinicians and nurses. This study reports the compilation of a multidisciplinary screening questionnaire and an analysis of the effectiveness of its implementation into clinical routine at the Department of Radiotherapy, Medical University of Vienna. Materials and methods: The screening questionnaire is based on a compilation of several subscales from established and validated assessment tools. It focuses on comprehensive information with high a clinical relevance for all professions. In a pilot study, patients' acceptance was assessed qualitatively. Analysis of missing screening data in consecutively admitted patients reflects the effectiveness of implementation and representativity of the data. A validation analysis of the psychological subscales was performed using external criteria and its internal consistency was tested with Cronbachs' {alpha}. Results: Qualitative patient acceptance of the screening questionnaire is good. The overall response rate in the screening procedure was 75 %. Missing patient screening data sets arose randomly - mainly due to organizational problems - and did not result in systematic errors. The psychological subscales identify highly distressed patients with a sensitivity of 89 and 78 %, and an internal consistency of 0.843 and 0.617. Conclusion: The multidisciplinary screening questionnaire compiled in this study has a high patient acceptance, provides reliable and representative data and identifies highly distressed patients with excellent sensitivity. Although requiring additional personnel resources, it can be implemented

  10. Validation and practical implementation of a multidisciplinary cancer distress screening questionnaire

    International Nuclear Information System (INIS)

    Background: In order to identify cancer patients with psychosocial needs during radiotherapy, a routine screening questionnaire is widely recommended in the literature. Several tools focusing mainly on psychological issues have been developed during the past decade. However, problems with their implementation into clinical routine have been repeatedly reported, due to a lack of practicability for clinicians and nurses. This study reports the compilation of a multidisciplinary screening questionnaire and an analysis of the effectiveness of its implementation into clinical routine at the Department of Radiotherapy, Medical University of Vienna. Materials and methods: The screening questionnaire is based on a compilation of several subscales from established and validated assessment tools. It focuses on comprehensive information with high a clinical relevance for all professions. In a pilot study, patients' acceptance was assessed qualitatively. Analysis of missing screening data in consecutively admitted patients reflects the effectiveness of implementation and representativity of the data. A validation analysis of the psychological subscales was performed using external criteria and its internal consistency was tested with Cronbachs' α. Results: Qualitative patient acceptance of the screening questionnaire is good. The overall response rate in the screening procedure was 75 %. Missing patient screening data sets arose randomly - mainly due to organizational problems - and did not result in systematic errors. The psychological subscales identify highly distressed patients with a sensitivity of 89 and 78 %, and an internal consistency of 0.843 and 0.617. Conclusion: The multidisciplinary screening questionnaire compiled in this study has a high patient acceptance, provides reliable and representative data and identifies highly distressed patients with excellent sensitivity. Although requiring additional personnel resources, it can be implemented successfully in

  11. Difficulties encountered and solutions found when implementing stereotactic radiotherapy of non-small cell lung cancer

    International Nuclear Information System (INIS)

    The aim of this paper is to describe the difficulties encountered when implementing stereotactic radiotherapy of non-small cell lung cancer (T1-T2, N0, M0) using a voluntary breath-hold technique. From 25/03/2010 to 22/02/2011, eight patients with a non-small cell lung cancer were selected for treatment. CT images were obtained with the patient maintaining breath-hold using a spirometer. Treatment was delivered when the patient maintains this level of breath-hold. Treatment was performed with a 4 MV and 10 MV photon beams from a linear accelerator Varian 2100CS, equipped with a 120 leaves collimator. 60 Gy or 48 Gy were delivered, in four sessions, to the 80% isodose. The planning target volume (PTV) was defined by adding a 5 mm margin to the internal target volume (ITV), the ITV corresponding to the gross tumour volume (GTV) plus a 3 mm margin. CTV is considered equal to GTV. The non-understanding of the gating technique, the great number of beams and the limited breath-hold times led to the failure of some treatments. It can be explained by some patients insufficient respiratory abilities and the low dose rate of one of the beams used for treatment, thus forcing some radiation fields to be delivered in two or three times. Implementing such a technique can be limited by the patients' physical abilities and the materials used. Some solutions were found: a training phase more intense with a coaching of the breath-hold technique more precise, or the use of an abdominal compression device. (authors)

  12. Illinois Breast and Cervical Cancer Program: Implementing Effective Public-Private Partnerships to Assure Population Health.

    Science.gov (United States)

    Handler, Arden S; Henderson, Vida A; Rosenfeld, Amy; Rankin, Kristin; Jones, Brenda; Issel, L Michele

    2015-01-01

    With the implementation of the Affordable Care Act (ACA), it is essential for the public health sector to elucidate its role with respect to its mission of assuring population health, and to clarify its role with respect to the private health care system. To that end, we examined the value added to the population health enterprise of successful public-private partnerships (PPPs) such as those found in the Illinois Breast and Cervical Cancer Program (IBCCP), the Centers for Disease Control and Prevention's (CDC's) National Breast and Cervical Cancer Early Detection Program (NBCCEDP) in Illinois. Key Informant (KI) interviews focused on IBCCP implementation were conducted with IBCCP lead agency (LA) program coordinators (n = 35/36) in winter 2012-2013. Analysis was conducted using Atlas.ti software. The KI interviews revealed the existence of highly developed PPPs between the IBCCP LAs and individual medical providers and hospitals across Illinois. The data suggest that the small amount of funding provided by IBCCP to each LA in Illinois has been used to build and sustain robust PPPs in the majority of the IBCCP communities. The PPPs developed through the IBCCP can be seen as an unplanned benefit of CDC's investment in breast and cervical health through the NBCCEDP. While the IBCCP/NBCCEDP might be considered a "boutique" categorical program which some may consider no longer necessary as individuals gain insurance under the ACA, the KI data underscore the critical role of public sector dollars, not only to serve individuals and communities directly but also to mobilize the private health care sector to act in partnership with public entities and become advocates for underserved communities. PMID:25470661

  13. Benefit Cost Analysis of Three Skin Cancer Public Education Mass-Media Campaigns Implemented in New South Wales, Australia.

    Science.gov (United States)

    Doran, Christopher M; Ling, Rod; Byrnes, Joshua; Crane, Melanie; Shakeshaft, Anthony P; Searles, Andrew; Perez, Donna

    2016-01-01

    Public education mass media campaigns are an important intervention for influencing behaviour modifications. However, evidence on the effectiveness of such campaigns to encourage the population to reduce sun exposure is limited. This study investigates the benefits and costs of three skin cancer campaigns implemented in New South Wales from 2006-2013. This analysis uses Australian dollars (AUD) and 2010-11 as the currency and base year, respectively. Historical data on skin cancer were used to project skin cancer rates for the period 2006-2020. The expected number of skin cancer cases is derived by combining skin cancer rates, sunburn rates and relative risk of skin cancers due to sun exposure. Counterfactual estimates are based on sunburn exposure in the absence of the campaigns. Monetary values are attached to direct (treatment) and indirect (productivity) costs saved due to fewer skin cancer cases. Monetary benefits are compared with the cost of implementing the campaigns and are presented in the form of a benefit-cost ratio. Relative to the counterfactual (i.e., no campaigns) there are an estimated 13,174 fewer skin cancers and 112 averted deaths over the period 2006-2013. The net present value of these benefits is $60.17 million and the campaign cost is $15.63 million. The benefit cost ratio is 3.85, suggesting that for every $1 invested a return of $3.85 is achieved. Skin cancer public education mass media campaigns are a good investment given the likely extent to which they reduce the morbidity, mortality and economic burden of skin cancer.

  14. Benefit Cost Analysis of Three Skin Cancer Public Education Mass-Media Campaigns Implemented in New South Wales, Australia.

    Directory of Open Access Journals (Sweden)

    Christopher M Doran

    Full Text Available Public education mass media campaigns are an important intervention for influencing behaviour modifications. However, evidence on the effectiveness of such campaigns to encourage the population to reduce sun exposure is limited. This study investigates the benefits and costs of three skin cancer campaigns implemented in New South Wales from 2006-2013. This analysis uses Australian dollars (AUD and 2010-11 as the currency and base year, respectively. Historical data on skin cancer were used to project skin cancer rates for the period 2006-2020. The expected number of skin cancer cases is derived by combining skin cancer rates, sunburn rates and relative risk of skin cancers due to sun exposure. Counterfactual estimates are based on sunburn exposure in the absence of the campaigns. Monetary values are attached to direct (treatment and indirect (productivity costs saved due to fewer skin cancer cases. Monetary benefits are compared with the cost of implementing the campaigns and are presented in the form of a benefit-cost ratio. Relative to the counterfactual (i.e., no campaigns there are an estimated 13,174 fewer skin cancers and 112 averted deaths over the period 2006-2013. The net present value of these benefits is $60.17 million and the campaign cost is $15.63 million. The benefit cost ratio is 3.85, suggesting that for every $1 invested a return of $3.85 is achieved. Skin cancer public education mass media campaigns are a good investment given the likely extent to which they reduce the morbidity, mortality and economic burden of skin cancer.

  15. Benefit Cost Analysis of Three Skin Cancer Public Education Mass-Media Campaigns Implemented in New South Wales, Australia.

    Science.gov (United States)

    Doran, Christopher M; Ling, Rod; Byrnes, Joshua; Crane, Melanie; Shakeshaft, Anthony P; Searles, Andrew; Perez, Donna

    2016-01-01

    Public education mass media campaigns are an important intervention for influencing behaviour modifications. However, evidence on the effectiveness of such campaigns to encourage the population to reduce sun exposure is limited. This study investigates the benefits and costs of three skin cancer campaigns implemented in New South Wales from 2006-2013. This analysis uses Australian dollars (AUD) and 2010-11 as the currency and base year, respectively. Historical data on skin cancer were used to project skin cancer rates for the period 2006-2020. The expected number of skin cancer cases is derived by combining skin cancer rates, sunburn rates and relative risk of skin cancers due to sun exposure. Counterfactual estimates are based on sunburn exposure in the absence of the campaigns. Monetary values are attached to direct (treatment) and indirect (productivity) costs saved due to fewer skin cancer cases. Monetary benefits are compared with the cost of implementing the campaigns and are presented in the form of a benefit-cost ratio. Relative to the counterfactual (i.e., no campaigns) there are an estimated 13,174 fewer skin cancers and 112 averted deaths over the period 2006-2013. The net present value of these benefits is $60.17 million and the campaign cost is $15.63 million. The benefit cost ratio is 3.85, suggesting that for every $1 invested a return of $3.85 is achieved. Skin cancer public education mass media campaigns are a good investment given the likely extent to which they reduce the morbidity, mortality and economic burden of skin cancer. PMID:26824695

  16. Modality-dependent dose requirements in the Austrian breast cancer early detection program. First results from technical quality assurance

    International Nuclear Information System (INIS)

    The Austrian Breast Cancer Early Detection Program (BKFP) has officially started in January 2014. In order to ensure that all participating women can rely on a sufficient cancer detection rate while at the same time the required dose is as low as reasonably achievable, all participating radiology institutes (approx. 200) have to fulfill strict quality assurance requirements. The control and certification is performed by the Reference Center for Technical Quality Assurance (RefZQS), which has been developing the methods and tolerances in a pilot project since 2007. The limits are defined in the EUREF-Oeprotocol which is based on the European EPQC guidelines. From the requirement for optimized image quality while simultaneously following the ALARA principle, we found modality-dependent dose requirements, which we had expected but which have now been compiled for the first time for Austria.

  17. Implementation of population screening for colorectal cancer by repeated fecal occult blood test in the Netherlands

    Directory of Open Access Journals (Sweden)

    Bossuyt Patrick MM

    2009-04-01

    Full Text Available Abstract Background Colorectal cancer (CRC is the third most prevalent type of cancer in the world. Its prognosis is closely related to the disease stage at the time of diagnosis. Early detection of symptomless CRC or precursor lesions through population screening could reduce CRC mortality. However, screening programs are only effective if enough people are willing to participate. This study aims to asses the uptake of a second round of fecal occult blood test (FOBt based screening and to explore factors that could potentially increase this uptake. Methods and design Two years after the first screening round, 10.000 average risk persons, aged 50 to 75, will again receive an invitation to participate in immunohistochemical FOBt (iFOBt based screening. Eligible persons will be recruited through a city population database. Invitees will be randomized to receive either an iFOBt with a faeces collection paper or an iFOBt without a collection paper. The iFOBts will be analyzed in a specialized laboratory at the Academic Medical Centre. Positive iFOBts will be followed by a consultation at our outpatient clinic and, in the absence of contra-indications and after informed consent, by a colonoscopy. The primary outcome measure is the participation rate. Secondary outcome measures are the effect of the addition of a collection paper on the participation rate, reasons for participation and non-participation, measures of informed choice and psychological consequences of screening and measures of psychological and physical burden associated with the iFOBt and the colonoscopy. Another secondary outcome measure is the diagnostic yield of the program. Discussion In order to implement population screening for colorectal cancer in the Netherlands, information is needed on the uptake of repeated rounds of FOBt-based screening and on factors that could potentially increase this uptake in the future since effectiveness of such a program depends on the willingness

  18. Implementation of cancer clinical care pathways: s successful model of collaboration between payers and providers.

    Science.gov (United States)

    Feinberg, Bruce A; Lang, James; Grzegorczyk, James; Stark, Donna; Rybarczyk, Thomas; Leyden, Thomas; Cooper, Joseph; Ruane, Thomas; Milligan, Scott; Stella, Phillip; Scott, Jeffrey A

    2012-05-01

    Despite rising medical costs within the US healthcare system, quality and outcomes are not improving. Without significant policy reform, the cost-quality imbalance will reach unsustainable proportions in the foreseeable future. The rising cost of healthcare in part results from an expanding aging population with an increasing number of life-threatening diseases. This is further compounded by a growing arsenal of high-cost therapies. In no medical specialty is this more apparent than in the area of oncology. Numerous attempts to reduce costs have been attempted, often with limited benefit and brief duration. Because physicians directly or indirectly control or influence the majority of medical care costs, physician behavioral changes must occur to bend the healthcare cost curve in a sustainable fashion. Experts within academia, health policy, and business agree that a significant paradigm change in stakeholder collaboration will be necessary to accomplish behavioral change. Such a collaboration has been pioneered by Blue Cross Blue Shield of Michigan and Physician Resource Management, a highly specialized oncology healthcare consulting firm with developmental and ongoing technical, analytic, and consultative support from Cardinal Health Specialty Solutions, a division of Cardinal Health. We describe a successful statewide collaboration between payers and providers to create a cancer clinical care pathways program. We show that aligned stakeholder incentives can drive high levels of provider participation and compliance in the pathways that lead to physician behavioral changes. In addition, claims-based data can be collected, analyzed, and used to create and maintain such a program. PMID:22694114

  19. Implementation of cervical cancer screening: A demonstration in a rural community of North India

    Directory of Open Access Journals (Sweden)

    Satyanarayana Labani

    2014-01-01

    Full Text Available Context: S trategies for implementation of cervical screening are the need of the hour while effective screening tests for early detection exist. Aim: To demonstrate the implementation of cervical cancer screening by aided visual tests in a North Indian rural community. Setting and Design: Cross-sectional study in a rural setting. Subjects and Methods: Baseline survey of community perspectives of screening and identification of eligible women of age 30-59 years was performed by Accredited Social Health Activists (ASHAs. Screening was targeted on 7604 women by the methods of visual inspection of cervix using acetic acid (VIA, by using lugol′s iodine (VILI tests and by Pap test. Screen positives were referred to colposcopy and further management. Data on evaluation parameters was collected. Statistical Analysis: Screening test performances were assessed by sensitivity, specificity and positive/negative predictive values (PPV/NPV for detection of histological CIN II+. Results: Study showed coverage of 65.6% of total eligible women (7604. Extent of agreement of visual testes (VIA/VILI between nurses and doctor was 77.3-100%. Screen positivity rates by VIA, VILI and Pap were 9.7%, 13.5% and 2.6%, respectively. Screen positives turned up for confirmatory diagnosis were 78%. Acceptance of treatment was 76%. Screen positivity of VIA and VILI declined (P < 0.001 with increase in age. Sensitivity, specificity, and PPV of VIA were 59.0%, 92.3% and 3.6% and of VILI were72.7%, 89.6% and 3.3% respectively. NPV was 99% in all the tests. Conclusion: Implementation of screening by aided visual tests was successfully demonstrated through utilization of ASHAs for motivation, achievement of good coverage and good response in clinical management of screen positives.

  20. Understanding critical barriers to implementing a clinical information system in a nursing home through the lens of a socio-technical perspective.

    Science.gov (United States)

    Or, Calvin; Dohan, Michael; Tan, Joseph

    2014-09-01

    This paper addresses key barriers to implementing a clinical information system (CIS) in a Hong Kong nursing home setting, from a healthcare specific socio-technical perspective. Data was collected through field observations (n = 12) and semi-structured individual interviews (n = 18) of CIS stakeholders in a Hong Kong nursing home, and analyzed using the immersion/crystallization approach. Complex interactions relevant to our case were contextualized and interpreted within the perspective of the Sittig-Singh Healthcare Socio-Technical Framework (HSTF). Three broad clusters of implementation barriers from the eight HSTF dimensions were identified: (a) Infrastructure-based barriers, which relate to conflict between government regulations and system functional needs of users; lack of financial support; inconsistency between workflow, work policy, and procedures; and inadequacy of hardware-software infrastructural and technical support; (b) Process-based barriers, which relate to mismatch between the technology, existing work practice and workflow, and communication; low system speed, accessibility, and stability; deficient computer literacy; more experience in health care profession; clinical content inadequacy and unavailability; as well as poor system usefulness and user interface design; and (c) Outcome-based barriers, which relate to the lack of measurement and monitoring of system effectiveness. Two additional dimensions underlining the importance of the ability of a CIS to change are proposed to extend the Sittig-Singh HSTF. First, advocacy would promote the articulation and influence of changes in the system and subsequent outcomes by CIS stakeholders, and second, adaptability would ensure the ability of the system to adjust to emerging needs. The broad set of discovered implementation shortcomings expands prior research on why CIS can fail in nursing home settings. Moreover, our investigation offers a knowledge base and recommendations that can serve

  1. Implementation and spread of interventions into the multilevel context of routine practice and policy: implications for the cancer care continuum.

    Science.gov (United States)

    Yano, Elizabeth M; Green, Lawrence W; Glanz, Karen; Ayanian, John Z; Mittman, Brian S; Chollette, Veronica; Rubenstein, Lisa V

    2012-05-01

    The promise of widespread implementation of efficacious interventions across the cancer continuum into routine practice and policy has yet to be realized. Multilevel influences, such as communities and families surrounding patients or health-care policies and organizations surrounding provider teams, may determine whether effective interventions are successfully implemented. Greater recognition of the importance of these influences in advancing (or hindering) the impact of single-level interventions has motivated the design and testing of multilevel interventions designed to address them. However, implementing research evidence from single- or multilevel interventions into sustainable routine practice and policy presents substantive challenges. Furthermore, relatively few multilevel interventions have been conducted along the cancer care continuum, and fewer still have been implemented, disseminated, or sustained in practice. The purpose of this chapter is, therefore, to illustrate and examine the concepts underlying the implementation and spread of multilevel interventions into routine practice and policy. We accomplish this goal by using a series of cancer and noncancer examples that have been successfully implemented and, in some cases, spread widely. Key concepts across these examples include the importance of phased implementation, recognizing the need for pilot testing, explicit engagement of key stakeholders within and between each intervention level; visible and consistent leadership and organizational support, including financial and human resources; better understanding of the policy context, fiscal climate, and incentives underlying implementation; explication of handoffs from researchers to accountable individuals within and across levels; ample integration of multilevel theories guiding implementation and evaluation; and strategies for long-term monitoring and sustainability. PMID:22623601

  2. Changes in acute response to radiation after implementation of new national guidelines for head and neck cancer

    DEFF Research Database (Denmark)

    Hansen, C. R.; Bertelsen, Anders; Zukauskaite, R.;

    2015-01-01

    Purpose/Objective: New national guidelines (GL) for radiotherapy (RT) of head and neck cancer (HNC) were implemented at the beginning of 2013. One purpose of the new GL was to nationally standardise the expansion from GTV to high risk CTV (CTV1). This standardisation has resulted in change...

  3. Technical procedures for implementation of acoustics site studies, Deaf Smith County site, Texas: Environmental Field Program: Preliminary draft

    Energy Technology Data Exchange (ETDEWEB)

    1987-09-01

    The purpose and scope of the technical procedure for processing data from the tethered meteorological system are covered. Definitions, interfaces, and concurrent data needs are also addressed. This technical procedure describes how to control, organize, verify, and archive tethered meteorological system data. These data will be received at the processing location from the field measurement location and are part of the characterization of the Deaf Smith County Site, Texas for the salt repository program. These measurements will be made in support of the sound propagation study and are a result of environmental data requirements for acoustics. 6 refs., 15 figs., 5 tabs.

  4. Colorectal cancer treatment in an ageing world - Technical advances, treatment decisions and multidisciplinary care

    NARCIS (Netherlands)

    Schiphorst, A.H.W.

    2015-01-01

    The incidence of colorectal cancer has risen in recent years and currently over 50% of patients are over 70 years of age. Many questions regarding the optimal management of the growing group of elderly colorectal cancer patients are still unanswered. The research presented in this thesis focuses on

  5. Technical procedures for implementation of background environmental radioactivity site studies, Deaf Smith County site, Texas: Environmental Field Program: Preliminary draft

    Energy Technology Data Exchange (ETDEWEB)

    1987-09-01

    The purpose of this technical procedure is to describe the method for performing field maintenance on low-volume air samplers and the associated topics of personnel and organization, procedure preparation, documentation, and quality assurance. The scope of this procedure includes the maintenance of low-volume air samplers in the field and does not encompass maintenance performed by the manufacturer.

  6. The NASA Scientific and Technical Information (STI) Program's Implementation of Open Archives Initiative (OAI) for Data Interoperability and Data Exchange.

    Science.gov (United States)

    Rocker, JoAnne; Roncaglia, George J.; Heimerl, Lynn N.; Nelson, Michael L.

    Interoperability and data-exchange are critical for the survival of government information management programs. E-government initiatives are transforming the way the government interacts with the public. More information is to be made available through Web-enabled technologies. Programs such as the NASA's Scientific and Technical Information (STI)…

  7. Technical procedures for implementation of background environmental radioactivity site studies, Deaf Smith County site, Texas: Environmental Field Program: Preliminary draft

    International Nuclear Information System (INIS)

    The purpose of this technical procedure is to describe the method for performing field maintenance on low-volume air samplers and the associated topics of personnel and organization, procedure preparation, documentation, and quality assurance. The scope of this procedure includes the maintenance of low-volume air samplers in the field and does not encompass maintenance performed by the manufacturer

  8. Transrectal high-intensity focused ultrasound (HIFU) treatment of localized prostate cancer: Review of technical incidents and morbidity after 5 years of use

    OpenAIRE

    RIPERT, Thomas; AZEMAR, Marie Dominique; MENARD, Johann; BAYOUD, Younes; Messaoudi, Rabah; Duval, François; Staerman, Frédéric

    2010-01-01

    Abstract OBJECTIVE To report on technical incidents, and early and late complications, occurring on high-intensity focused ultrasound (HIFU) treatment of patients with localized prostate cancer. PATIENTS AND METHODS We performed a retrospective review of patients who were treated by Ablatherm? in our centre. We recorded all technical incidents, treatment discontinuations, and early (< 1 month) and late complications. RESULTS A total of 74 HIFU procedures were perfor...

  9. Implementation of cancer clinical care pathways: a successful model of collaboration between payers and providers.

    Science.gov (United States)

    Feinberg, Bruce A; Lang, James; Grzegorczyk, James; Stark, Donna; Rybarczyk, Thomas; Leyden, Thomas; Cooper, Joseph; Ruane, Thomas; Milligan, Scott; Stella, Philip; Scott, Jeffrey A

    2012-05-01

    Despite rising medical costs within the US health care system, quality and outcomes are not improving. Without significant policy reform, the cost-quality imbalance will reach unsustainable proportions in the foreseeable future. The rising cost of health care in part results from an expanding aging population with an increasing number of life-threatening diseases. This is further compounded by a growing arsenal of high-cost therapies. In no medical specialty is this more apparent than in the area of oncology. Numerous attempts to reduce costs have been attempted, often with limited benefit and brief duration. Because physicians directly or indirectly control or influence the majority of medical care costs, physician behavioral changes must occur to bend the health care cost curve in a sustainable fashion. Experts within academia, health policy, and business agree that a significant paradigm change in stakeholder collaboration will be necessary to accomplish behavioral change. Such a collaboration has been pioneered by Blue Cross Blue Shield of Michigan and Physician Resource Management, a highly specialized oncology health care consulting firm with developmental and ongoing technical, analytic, and consultative support from Cardinal Health Specialty Solutions, a division of Cardinal Health. We describe a successful statewide collaboration between payers and providers to create a cancer clinical care pathways program. We show that aligned stakeholder incentives can drive high levels of provider participation and compliance in the pathways that lead to physician behavioral changes. In addition, claims-based data can be collected, analyzed, and used to create and maintain such a program. PMID:22942833

  10. Sections prepared for inclusion in an IAEA technical document handbook on Designing and Implementing a Physical Protection System

    Energy Technology Data Exchange (ETDEWEB)

    Snell, Mark K. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-11-01

    Two major sections were drafted (each with several subsections) for the IAEA dealing with designing and implementing a Physical Protection System (PPS). Areas addressed were Search Systems and the evaluation of PPS effectiveness.

  11. An evolutionary approach to groupware implementation: the context of requirements engineering in the socio-technical frame

    NARCIS (Netherlands)

    Pumareja, Dulce; Sikkel, Klaas

    2002-01-01

    Organizational implementation of new technology brings about design challenges as issues of requirements and evolving requirements emerge. For groupware systems, issues are much more problematic as processes surrounding the performance of collaborative work are dynamic, unpredictable, hard to captur

  12. Implementation of a Lateral TBI protocol in a Mexican Cancer Center

    Science.gov (United States)

    Mesa, Francisco; Esquivel, Carlos; Eng, Tony; Papanikolaou, Niko; Sosa, Modesto A.

    2008-08-01

    The development of a Lateral Total Body Irradiation protocol to be implemented at a High Specialty Medical Unit in Mexico as preparatory regimen for bone marrow transplant and treatment of several lymphomas is presented. This protocol was developed following AAPM specifications and has been validated for application at a cancer care center in United States. This protocol fundamentally focuses on patient care, avoiding instability and discomfort that may be encountered by other treatment regimes. In vivo dose verification with TLD-100 chips for each anatomical region of interest was utilized. TLD-100 chips were calibrated using a 6 MV photon beam for 10-120 cGy. Experimental results show TLD measurements with an error less than 1%. Standard deviations for calculated and measured doses for seven patients have been obtained. Data gathered for different levels of compensation indicate that a 3% measured tolerance level is acceptable. TLD point-dose measurements have been used to verify the dose beyond partial transmission lung blocks. Dose measurements beyond the lung block showed variation about 50% respects to prescribe dose. Midplane doses to the other anatomical sites were less than 2.5% respect of the prescribed dose.

  13. Population prevalence of hereditary breast cancer phenotypes and implementation of a genetic cancer risk assessment program in southern Brazil

    Directory of Open Access Journals (Sweden)

    Edenir I. Palmero

    2009-01-01

    Full Text Available In 2004, a population-based cohort (the Núcleo Mama Porto Alegre - NMPOA Cohort was started in Porto Alegre, southern Brazil and within that cohort, a hereditary breast cancer study was initiated, aiming to determine the prevalence of hereditary breast cancer phenotypes and evaluate acceptance of a genetic cancer risk assessment (GCRA program. Women from that cohort who reported a positive family history of cancer were referred to GCRA. Of the 9218 women enrolled, 1286 (13.9% reported a family history of cancer. Of the 902 women who attended GCRA, 55 (8% had an estimated lifetime risk of breast cancer ³ 20% and 214 (23.7% had pedigrees suggestive of a breast cancer predisposition syndrome; an unexpectedly high number of these fulfilled criteria for Li-Fraumeni-like syndrome (122 families, 66.7%. The overall prevalence of a hereditary breast cancer phenotype was 6.2% (95%CI: 5.67-6.65. These findings identified a problem of significant magnitude in the region and indicate that genetic cancer risk evaluation should be undertaken in a considerable proportion of the women from this community. The large proportion of women who attended GCRA (72.3% indicates that the program was well-accepted by the community, regardless of the potential cultural, economic and social barriers.

  14. Technical Assistance Needs for Successful Implementation of Couples HIV Testing and Counseling (CHTC) Intervention for Male Couples at US HIV Testing Sites.

    Science.gov (United States)

    Stephenson, Rob; Grabbe, Kristina L; Sidibe, Turquoise; McWilliams, Anthony; Sullivan, Patrick S

    2016-04-01

    The African couples HIV testing and counseling (CHTC) model, which focuses on heterosexual couples, was adapted for same-sex male couples in the US. This paper presents the results of a follow-up survey conducted with representatives of the agencies that received CHTC training. The paper aims to understand the post-training implementation and identify critical technical assistance gaps. There are clear needs for continual learning opportunities, focused on the key skills required for CHTC, and for resources aimed at tackling agency-level concerns about service provision and integration. Central to this is the need for implementation science research that can identify the messages that are effective in encouraging couples to utilize CHTC and test models of service integration. PMID:26253221

  15. Technical Assistance Needs for Successful Implementation of Couples HIV Testing and Counseling (CHTC) Intervention for Male Couples at US HIV Testing Sites.

    Science.gov (United States)

    Stephenson, Rob; Grabbe, Kristina L; Sidibe, Turquoise; McWilliams, Anthony; Sullivan, Patrick S

    2016-04-01

    The African couples HIV testing and counseling (CHTC) model, which focuses on heterosexual couples, was adapted for same-sex male couples in the US. This paper presents the results of a follow-up survey conducted with representatives of the agencies that received CHTC training. The paper aims to understand the post-training implementation and identify critical technical assistance gaps. There are clear needs for continual learning opportunities, focused on the key skills required for CHTC, and for resources aimed at tackling agency-level concerns about service provision and integration. Central to this is the need for implementation science research that can identify the messages that are effective in encouraging couples to utilize CHTC and test models of service integration.

  16. Final Report. SFAA No. DEFC02-98CH10961. Technical assistance for joint implementation and other supporting mechanisms and measures for greenhouse gas emissions mitigation

    Energy Technology Data Exchange (ETDEWEB)

    Knight, Denise

    2001-10-15

    IIEC, a division of CERF, has developed an extensive base of experience implementing activities that support climate action by developing USIJI projects in transitional countries within Asia, Latin America, Central and Eastern Europe, and southern Africa. IIEC has been able to provide a range of technical and policy assistance to governments and industry in support of sustainable energy use. IIEC continues to work in key countries with local partners to develop and implement energy efficiency policies and standards, develop site-specific projects, and assist governing bodies to establish national priorities and evaluation criteria for approving GHG-mitigation projects. As part of this project, IIEC focused on promoting a series of activities in Thailand and South Africa in order to identify GHG mitigation projects and work within the national approval process of those countries. The sections of this report outline the activities conducted in each country in order to achieve that goal.

  17. Implementing efficient and sustainable collaboration between National Immunization Technical Advisory Groups: Report on the 3rd International Technical Meeting, Paris, France, 8-9 December 2014.

    Science.gov (United States)

    Perronne, Christian; Adjagba, Alex; Duclos, Philippe; Floret, Daniel; Houweling, Hans; Le Goaster, Corinne; Lévy-Brühl, Daniel; Meyer, François; Senouci, Kamel; Wichmann, Ole

    2016-03-01

    Many experts on vaccination are convinced that efforts should be made to encourage increased collaboration between National Immunization Technical Advisory Groups on immunization (NITAGs) worldwide. International meetings were held in Berlin, Germany, in 2010 and 2011, to discuss improvement of the methodologies for the development of evidence-based vaccination recommendations, recognizing the need for collaboration and/or sharing of resources in this effort. A third meeting was held in Paris, France, in December 2014, to consider the design of specific practical activities and an organizational structure to enable effective and sustained collaboration. The following conclusions were reached: (i) The proposed collaboration needs a core functional structure and the establishment or strengthening of an international network of NITAGs. (ii) Priority subjects for collaborative work are background information for recommendations, systematic reviews, mathematical models, health economic evaluations and establishment of common frameworks and methodologies for reviewing and grading the evidence. (iii) The programme of collaborative work should begin with participation of a limited number of NITAGs which already have a high level of expertise. The amount of joint work could be increased progressively through practical activities and pragmatic examples. Due to similar priorities and already existing structures, this should be organized at regional or subregional level. For example, in the European Union a project is funded by the European Centre for Disease Prevention and Control (ECDC) with the aim to set up a network for improving data, methodology and resource sharing and thereby supporting NITAGs. Such regional networking activities should be carried out in collaboration with the World Health Organization (WHO). (iv) A global steering committee should be set up to promote international exchange between regional networks and to increase the involvement of less experienced

  18. Implementing efficient and sustainable collaboration between National Immunization Technical Advisory Groups: Report on the 3rd International Technical Meeting, Paris, France, 8-9 December 2014.

    Science.gov (United States)

    Perronne, Christian; Adjagba, Alex; Duclos, Philippe; Floret, Daniel; Houweling, Hans; Le Goaster, Corinne; Lévy-Brühl, Daniel; Meyer, François; Senouci, Kamel; Wichmann, Ole

    2016-03-01

    Many experts on vaccination are convinced that efforts should be made to encourage increased collaboration between National Immunization Technical Advisory Groups on immunization (NITAGs) worldwide. International meetings were held in Berlin, Germany, in 2010 and 2011, to discuss improvement of the methodologies for the development of evidence-based vaccination recommendations, recognizing the need for collaboration and/or sharing of resources in this effort. A third meeting was held in Paris, France, in December 2014, to consider the design of specific practical activities and an organizational structure to enable effective and sustained collaboration. The following conclusions were reached: (i) The proposed collaboration needs a core functional structure and the establishment or strengthening of an international network of NITAGs. (ii) Priority subjects for collaborative work are background information for recommendations, systematic reviews, mathematical models, health economic evaluations and establishment of common frameworks and methodologies for reviewing and grading the evidence. (iii) The programme of collaborative work should begin with participation of a limited number of NITAGs which already have a high level of expertise. The amount of joint work could be increased progressively through practical activities and pragmatic examples. Due to similar priorities and already existing structures, this should be organized at regional or subregional level. For example, in the European Union a project is funded by the European Centre for Disease Prevention and Control (ECDC) with the aim to set up a network for improving data, methodology and resource sharing and thereby supporting NITAGs. Such regional networking activities should be carried out in collaboration with the World Health Organization (WHO). (iv) A global steering committee should be set up to promote international exchange between regional networks and to increase the involvement of less experienced

  19. Monitoring of IL/HL, LL waste repository in a clay formation: objectives, technical know-how, implementation strategy

    International Nuclear Information System (INIS)

    implementation into long-term evolution models. This type of surveillance should not be considered as a way to compensate for the lack of knowledge at a previous stage. Indeed, enough confidence in models and parameters contributing to a safety case will have been acquired, for instance in a URL, prior to authorisation and operation of a repository. Such prior knowledge, however, cannot be tested on the full pre-closure time scale or length scale of a repository. The observation of host rock and repository component evolution provides information to stakeholders throughout the pre closure period. Such added knowledge may contribute to improve stakeholder confidence in the process. It is taken into account to support the decisions pertaining to a step-wise, reversible repository management. For example, it may support a decision for disposal cell closure, it allows evaluating the feasibility of waste retrieval at successive stages of a stepwise closure, and it may contribute to update the design of disposal cells or access drifts yet to be built. Monitoring activities are subject to repository-specific constraints such as: materials must not interfere with operational safety; material must not reduce long term safety significantly; materials must operate under expected environmental conditions. The establishment of monitoring activities will draw on similarities with other systems that are subject to monitoring activities (e.g. monitoring of concrete and clayey structures in dams, steel structures in pipelines, railway tunnels, etc.). The key lessons from those activities point to the importance of the correct interpretation of measurements and the need for redundancy, as well as for pre-testing and careful installation of monitoring equipment. The selection criteria for adequate monitoring methods include safety, robustness and ease of integration in an automatic data acquisition network. Andra outlined a potential and preliminary monitoring strategy, as part of a repository

  20. Implementing a One-on-One Peer Support Program for Cancer Survivors Using a Motivational Interviewing Approach: Results and Lessons Learned

    OpenAIRE

    Allicock, Marlyn; Carr, Carol; Johnson, La-Shell; Smith, Rosie; Lawrence, Mary; Kaye, Leanne; Gellin, Mindy; Manning, Michelle

    2014-01-01

    Peer Connect matches cancer survivors and caregivers (guides) with those currently experiencing cancer-related issues seeking support (partners). Motivational interviewing (MI)-based communication skills are taught to provide patient-centered support. There is little guidance about MI-based applications with cancer survivors who may have multiple coping needs. This paper addresses the results and lessons learned from implementing Peer Connect. Thirteen cancer survivors and two caregivers rece...

  1. Technical meeting on lessons learned with respect to SAT implementation, including development of trainers and use of cost effective training methods

    International Nuclear Information System (INIS)

    The past years have brought some significant changes in the world energy market, where the nuclear power plants and utilities are operating. Part of NPPs is privatised now; the electricity markets are liberalized and become more and more international. Due to the increase of competition, the power production costs are now monitored more closely than before. The opening of electricity markets has led the nuclear power plants to be under the serious economic pressure with a demand for continuous cost reduction. All these require from NPPs to make their personnel training more cost-effective. In addition, based on modern technology, a great amount of new training tools, aids and technologies have been introduced during the last 2-3 years, these new opportunities can be quite useful for training cost optimization. On the basis of experience gained worldwide in the application of the systematic approach to training (SAT), SAT based training is now a broad integrated approach emphasizing not only technical knowledge and skills but also human factor related knowledge, skills and attitudes. In this way, all competency requirements for attaining and maintaining personnel competence and qualification can be met, thus promoting and strengthening quality culture and safety culture, which should be fostered throughout the initial and continuing training programmes. The subject of the present technical meeting was suggested by the members of the Technical Working Group on Training and Qualification of NPP Personnel (TWG-T and Q) and supported by a number of the IAEA meetings on NPP personnel training. The technical Meeting on 'Lessons Learned with Respect to SAT Implementation, Including Development of Trainers and Use of Cost Effective Training Methods' was organized by the IAEA in co-operation with the Tecnatom A.S. and was held from 21 to 24 October 2002 in San Sebastian de los Reyes/ Madrid, Spain. The main objective of the meeting was to provide an international forum for

  2. Cancer-associated immune-mediated syndromes: Pathogenic values and clinical implementation.

    Science.gov (United States)

    Suchkov, S V; Petrunin, D D; Kostalevskaya, A V; Kachkov, I A; Elbeik, T; Matsuura, E; Paltsev, M A

    2007-07-01

    The ability of tumors to provoke formation of cancer-associated secondary immunodeficiency (CASID) with predominant suppression of CMI and cancer-associated secondary immunodeficiency with clinical autoimmunity syndrome (CASICAS) with triggering of a set of the autoimmune deviations is appearing to be a key event in the restriction of hosts' anti-tumor immunity. Earlier the existence of the above-mentioned syndromes was demonstrated in BCC and GBM patients. In order to reach a point where immunological phenotypes in GBM and BCC can be clarified clinically and, partly, pathogenically, we have conducted a series of studies of typical and atypical types of immune responsiveness in patients with GBM and BCC. For GBM and BCC three scenarios of the involvement of the immune responsiveness have been established in a series of our studies, i.e., (i) malignancy with no immunopathology, (ii) malignancy as CASID, and (iii) malignancy as CASICAS. All of those scenarios demonstrated significant differences in their immune-mediated manifestations which, in turn, were proven to reveal close associative relationships with a specific clinicopathologic type and clinical manifestations of the tumor. CASID and CASICAS share two common features, i.e., (i) signs of immunodeficiency and (ii) a tandem of the deviations within the adaptive and innate links of the host immune responsiveness. At the same time, CASID and CASICAS are distinct pathogenically and clinically, and in terms of depth of the immune deviations observed, CASID patients manifest a breakage in both links, whereas in CASICAS patients, a breakage in the adaptive link would dominate. To get these differences clarified, we summarized major types of the immune imbalances and sets of clinical and clinicopathologic manifestations to illustrate the above-mentioned features in CASID and CASICAS patients. There are distinct close correlations between clinicopathologic features of the disease course and sets of the immune

  3. Implementation of population screening for colorectal cancer by repeated Fecal Immunochemical Test (FIT: third round

    Directory of Open Access Journals (Sweden)

    Stegeman Inge

    2012-06-01

    Full Text Available Abstract Background Colorectal cancer (CRC is the most common cancer in Europe with a mortality rate of almost 50%. The prognosis of patients is largely determined by the clinical and pathological stage at the time of diagnosis. Population screening has been shown to reduce CRC-related mortality rate. Most screening programs worldwide rely on fecal immunochemical testing (FIT. The effectiveness of a FIT screening program is not only influenced by initial participation rate, but also by program adherence during consecutive screening rounds. We aim to evaluate the participation rate in and yield of a third CRC screening round using FIT. Methods and design Four years after the first screening round and two years after the second round, a total number of approximately 11,000 average risk individuals (50 to 75 years of age will be invited to participate in a third round of FIT-based CRC screening. We will select individuals in the same target area as in the previous screening rounds, using the electronic database of the regional municipal administration registrations. We will invite all FIT-negatives and all non-participants in previous screening rounds, as well as eligible first time invitees who have moved into the area or have become 50 years of age. FITs will be analyzed in the special technique laboratory of the Academic Medical Center of the University of Amsterdam. All FIT-positives will be invited for a consultation at the outpatient clinic. In the absence of contra-indications, a colonoscopy will follow at the Academic Medical Center or at the Flevohospital. The primary outcome measures are the participation rate, defined as the proportion of invitees that return a FIT in this third round of FIT-screening, and the diagnostic yield of the program. Implications This study will provide precise data on the participation in later FIT screening rounds. This enables to estimate the effectiveness of CRC screening programs that rely on repeated

  4. Technical Evaluation of the NASA Model for Cancer Risk to Astronauts Due to Space Radiation

    Science.gov (United States)

    2012-01-01

    At the request of NASA, the National Research Council's (NRC's) Committee for Evaluation of Space Radiation Cancer Risk Model reviewed a number of changes that NASA proposes to make to its model for estimating the risk of radiation-induced cancer in astronauts. The NASA model in current use was last updated in 2005, and the proposed model would incorporate recent research directed at improving the quantification and understanding of the health risks posed by the space radiation environment. NASA's proposed model is defined by the 2011 NASA report Space Radiation Cancer Risk Projections and Uncertainties 2010 (Cucinotta et al., 2011). The committee's evaluation is based primarily on this source, which is referred to hereafter as the 2011 NASA report, with mention of specific sections or tables cited more formally as Cucinotta et al. (2011). The overall process for estimating cancer risks due to low linear energy transfer (LET) radiation exposure has been fully described in reports by a number of organizations. They include, more recently: (1) The "BEIR VII Phase 2" report from the NRC's Committee on Biological Effects of Ionizing Radiation (BEIR) (NRC, 2006); (2) Studies of Radiation and Cancer from the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR, 2006), (3) The 2007 Recommendations of the International Commission on Radiological Protection (ICRP), ICRP Publication 103 (ICRP, 2007); and (4) The Environmental Protection Agency s (EPA s) report EPA Radiogenic Cancer Risk Models and Projections for the U.S. Population (EPA, 2011). The approaches described in the reports from all of these expert groups are quite similar. NASA's proposed space radiation cancer risk assessment model calculates, as its main output, age- and gender-specific risk of exposure-induced death (REID) for use in the estimation of mission and astronaut-specific cancer risk. The model also calculates the associated uncertainties in REID. The general approach for

  5. [Resection of the portal vein in pancreatectomy for cancer: technical considerations. Apropos of 4 cases].

    Science.gov (United States)

    Christophe, M; Thomas, P; Le Treut, Y P; Pol, B; Brandone, J M; Capobianco, C; Bricot, R

    1991-01-01

    Out of 150 carcinomas of the pancreas operated from 1970 through 1989, 50 pancreatectomies were performed, including 4 cases of segmental resection of portal vein with total pancreatectomy (2 cases) or duodenopancreatectomy (2 cases). The technical procedure is described and discussed. Segmental resection of portal vein is rare in our experience and has been always performed out of necessity because of the over estimation of the resectability. However, mortality and post-operative stay are not increased. PMID:1859109

  6. Technical Problems in Implementing University-Level Computer-Assisted Instruction in Mathematics and Science: Second Annual Report.

    Science.gov (United States)

    Levine, Arvin; And Others

    Difficulties in implementing the EXCHECK/Voice Oriented Curriculum Author Language (VOCAL) System, a general program designed for university-level computer-assisted instruction in mathematics and science written in the VOCAL language, are presented in terms of informal mathematical procedures, audio and prosodic features, and a schedule of…

  7. A Journey through Meaningful Use at a Large Academic Medical Center: Lessons of Leadership, Administration, and Technical Implementation

    OpenAIRE

    Unger, Melissa D.; Aldrich, Alison M; Hefner, Jennifer L.; Rizer, Milisa K.

    2014-01-01

    Successfully reporting meaningful use of electronic health records to the Centers for Medicare and Medicaid Services can be a challenging process, particularly for healthcare organizations with large numbers of eligible professionals. This case report describes a successful meaningful use attestation process undertaken at a major academic medical center. It identifies best practices in the areas of leadership, administration, communication, ongoing support, and technological implementation.

  8. Enhancing the implementation of Occupational Health and Safety interventions through a design of the socio-technical interaction

    DEFF Research Database (Denmark)

    Masi, Donato; Cagno, E.; Hasle, Peter;

    2014-01-01

    A multitude of Occupational Health and Safety (OHS) interventions have proven to be effective under controlled conditions, but their implementation in practice is often difficult and interventions may therefore not work as expected, especially when referring to Small and Medium sized Enterprises...

  9. Technical information on implementation-aids for overhead lines; Technische Erlaeuterungen zu der Vollzugshilfe fuer Freileitungen. Eine Uebersichtsbeschreibung

    Energy Technology Data Exchange (ETDEWEB)

    Kegel, R. [Institut fuer Elektromagnetische Vertraeglichkeit - IEV GmbH, Luebeck (Germany); Berger, W. [Electrosuisse, Fehraltorf (Switzerland)

    2008-07-01

    This article reviews the situation in Switzerland and the provisional implementation-aid published by the Swiss Federal Office of Environment in 2007. This implementation-aid concerns the limits for the magnetic fields produced by electrical installations operated at a voltage of 1 kV and more. The two-working-point model stipulated in the implementation-aid and the design current defined for certain environmental conditions and for a set of cross-sections are discussed. As these conditions hardly ever occur together in real life, calculation programmes and validations for real-life situations are discussed. Real-life conditions are discussed on the basis of a specific example of an overhead power line. The five-step calculation procedure used in the implementation-aid is described in detail. Further topics discussed include power-flow direction and the operation of grid control centres. Calculation examples are provided for the currents, voltages and magnetic fields involved. Finally, several digital calculation methods developed since 1990 are examined.

  10. Tolerance and toxicity of neoadjuvant docetaxel, cisplatin and 5 fluorouracil regimen in technically unresectable oral cancer in resource limited rural based tertiary cancer center

    Directory of Open Access Journals (Sweden)

    V M Patil

    2014-01-01

    Full Text Available Background: Recent studies indicate neoadjuvant chemotherapy (NACT can result in R0 resection in a substantial proportion of patients with technically unresectable oral cavity cancers. However, data regarding the efficacy and safety of docetaxel, cisplatin and 5 fluorouracil (TPF NACT in our setting is lacking. The present audit was proposed to evaluate the toxicities encountered during administration of this regimen. It was hypothesized that TPF NACT would be considered feasible for routine administration if an average relative dose intensity (ARDI of ≥0.90 or more in at least 70% of the patients. Materials and Methods: Technically unresectable oral cancers with Eastern Cooperative Oncology Group PS 0-2, with biopsy proven squamous cell carcinoma underwent two cycles of NACT with TPF regimen. Toxicity and response rates were noted following the CTCAE 4.03 and RECIST criteria. Descriptive analysis of completion rates (completing 2 cycles of planned chemotherapy with ARDI of 0.85 or more, reason for delay, toxicity, and response are presented. Results: The NACT was completed by all patients. The number of subjects who completed all planned cycles of chemotherapy are with the ARDI of the delivered chemotherapy been equal to or >0.85 was 11 (91.67%. All toxicity inclusive Grade 3-5 toxicity was seen in 11 patients (91.67%. The response rate of chemotherapy was 83.33%. There were three complete response, seven partial response, and two stable disease seen post NACT in this study. Conclusion: Docetaxel, cisplatin and 5 fluorouracil regimen can be routinely administered at our center with the supportive care methods and precautionary methods used in our study.

  11. Technical advances in endoscopic ultrasound-guided fiducial placement for the treatment of pancreatic cancer

    NARCIS (Netherlands)

    Chavalitdhamrong, D.; DiMaio, C.J.; Siersema, P.D.; Wagh, M.S.

    2015-01-01

    Radiation therapy has an important role in the treatment of locally advanced or metastatic pancreatic cancer and can be used alone or in conjunction with surgery and/or systemic chemotherapy. Because of the challenge of delivering an accurate and optimal radiation dose, image-guided radiation therap

  12. Technical description of endoscopic ultrasonography with fine-needle aspiration for the staging of lung cancer

    NARCIS (Netherlands)

    Kramer, H; van Putten, JWG; Douma, WR; Smidt, AA; van Dullemen, HM; Groen, HJM

    2005-01-01

    Background: Encloscopic ultrasonography (EUS) is a novel method for staging of the mediastinum in lung cancer patients. The recent development of linear scanners enables safe and accurate fine-needle aspiration (FNA) of mediastinal and upper abdominal structures under real-time ultrasound guidance.

  13. A qualitative assessment of implementing a cross-cultural survey on cancer wards in Denmark--a description of barriers

    DEFF Research Database (Denmark)

    Kristiansen, Maria; Hassani, Amani; Krasnik, Allan

    2010-01-01

    Research into migration and health is often confronted with methodological challenges related to the identification of migrants in various settings. Furthermore, it is often difficult to reach an acceptable level of participation among migrant groups in quantitative research. The aim of this study...... is to conduct a qualitative assessment of the barriers encountered during the implementation of a cross-cultural survey on cancer wards in Copenhagen, Denmark....

  14. Rationale, design, and implementation protocol of the Dutch clinical practice guideline Pain in patients with cancer: a cluster randomised controlled trial with short message service (SMS and interactive voice response (IVR

    Directory of Open Access Journals (Sweden)

    te Boveldt Nienke

    2011-12-01

    Full Text Available Abstract Background One-half of patients with cancer have pain. In nearly one out of two cancer patients with pain, this was undertreated. Inadequate pain control still remains an important problem in this group of patients. Therefore, in 2008 a national, evidence-based multidisciplinary clinical practice guideline 'pain in patients with cancer' has been developed. Yet, publishing a guideline is not enough. Implementation is needed to improve pain management. An innovative implementation strategy, Short Message Service with Interactive Voice Response (SVS-IVR, has been developed and pilot tested. This study aims to evaluate on effectiveness of this strategy to improve pain reporting, pain measurement and adequate pain therapy. In addition, whether the active role of the patient and involvement of caregivers in pain management may change. Methods/design A cluster randomised controlled trial with two arms will be performed in six oncology outpatient clinics of hospitals in the Southeastern region of the Netherlands, with three hospitals in the intervention and three in the control condition. Follow-up measurements will be conducted in all hospitals to study the long-term effect of the intervention. The intervention includes training of professionals (medical oncologists, nurses, and general practitioners and SMS-IVR to report pain in patients with cancer to improve pain reporting by patients, pain management by medical oncologists, nurses, and general practitioners, and decrease pain intensity. Discussion This innovative implementation strategy with technical tools and the involvement of patients, may enhance the use of the guideline 'pain in patients with cancer' for pain management. Short Message Service alerts may serve as a tool to support self-management of patients. Therefore, the SMS-IVR intervention may increase the feeling of having control over one's life. Trail registration Netherlands Trial Register (NTR: NTR2739

  15. Technical Evaluation of the NASA Model for Cancer Risk to Astronauts Due to Space Radiation

    Science.gov (United States)

    2012-01-01

    At the request of NASA, the National Research Council's (NRC's) Committee for Evaluation of Space Radiation Cancer Risk Model1 reviewed a number of changes that NASA proposes to make to its model for estimating the risk of radiation-induced cancer in astronauts. The NASA model in current use was last updated in 2005, and the proposed model would incorporate recent research directed at improving the quantification and understanding of the health risks posed by the space radiation environment. NASA's proposed model is defined by the 2011 NASA report Space Radiation Cancer Risk Projections and Uncertainties--2010 . The committee's evaluation is based primarily on this source, which is referred to hereafter as the 2011 NASA report, with mention of specific sections or tables. The overall process for estimating cancer risks due to low linear energy transfer (LET) radiation exposure has been fully described in reports by a number of organizations. The approaches described in the reports from all of these expert groups are quite similar. NASA's proposed space radiation cancer risk assessment model calculates, as its main output, age- and gender-specific risk of exposure-induced death (REID) for use in the estimation of mission and astronaut-specific cancer risk. The model also calculates the associated uncertainties in REID. The general approach for estimating risk and uncertainty in the proposed model is broadly similar to that used for the current (2005) NASA model and is based on recommendations by the National Council on Radiation Protection and Measurements. However, NASA's proposed model has significant changes with respect to the following: the integration of new findings and methods into its components by taking into account newer epidemiological data and analyses, new radiobiological data indicating that quality factors differ for leukemia and solid cancers, an improved method for specifying quality factors in terms of radiation track structure concepts as

  16. Technical-Environmental-Economical Evaluation of the Implementation of a Highly Efficient District Heating System in China

    DEFF Research Database (Denmark)

    Zhang, Lipeng

    . The third sub-hypothesis focused on integrating DHW supply into DH systems to improve the overall efficiency of Chinese DH systems. A typical issue in Chinese DH systems is that the DH plant has to provide much more heat than the consumers actually need. The main reason for this is the lack of flow control...... heating systems if the appropriate flow and pressure control devices are applied to the terminal heat emitters. The basic configuration of the technical approach is to apply Thermostatic Radiator Valves (TRV) with pre-setting function to radiators, and apply differential pressure controllers...... was simulated using IDA Indoor Climate and Energy 4.6.2. The results show the hydraulically balanced heating system achieves 16% heat savings and 74% pump electricity savings. The second sub-hypothesis was that indoor comfort can be improved by activating the thermostatic sensors of TRV. At present, heating...

  17. Genetic alterations in sporadic and hereditary colorectal cancer: implementations for screening and follow-up.

    Science.gov (United States)

    Souglakos, John

    2007-01-01

    The genetics underlying an inherited predisposition to cancer are rapidly being uncovered. This fact may ultimately lead to the routine use of molecular tools to diagnose these disorders, and establish interventions to prevent the development of cancer. Among the multiple cancer family syndromes, several are known to be associated with the development of colon cancer. These disorders may be diagnosed during evaluation of the index patient or during screening of family members who are at risk. Although the effectiveness of screening and surveillance strategies is unproven in controlled clinical trials for any of these syndromes, the high cancer risk warrants screening, and reasonable recommendations can be made. Several other genetic syndromes are associated with gastrointestinal polyposis. The risk of colon cancer in these diseases is uncertain, and may not be increased and they are not mentioned in this review. Examples include Cowden disease, intestinal ganglioneuromatosis, Ruvalcaba-Myhre-Smith syndrome, Devon family syndrome, and Cronkite-Canada syndrome. PMID:17384504

  18. Technical guidelines for head and neck cancer IMRT on behalf of the Italian association of radiation oncology - head and neck working group

    International Nuclear Information System (INIS)

    Performing intensity-modulated radiotherapy (IMRT) on head and neck cancer patients (HNCPs) requires robust training and experience. Thus, in 2011, the Head and Neck Cancer Working Group (HNCWG) of the Italian Association of Radiation Oncology (AIRO) organized a study group with the aim to run a literature review to outline clinical practice recommendations, to suggest technical solutions and to advise target volumes and doses selection for head and neck cancer IMRT. The main purpose was therefore to standardize the technical approach of radiation oncologists in this context. The following paper describes the results of this working group. Volumes, techniques/strategies and dosage were summarized for each head-and-neck site and subsite according to international guidelines or after reaching a consensus in case of weak literature evidence

  19. PNNL Technical Support to The Implementation of EMTA and EMTA-NLA Models in Autodesk® Moldflow® Packages

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Ba Nghiep; Wang, Jin

    2012-12-01

    Under the Predictive Engineering effort, PNNL developed linear and nonlinear property prediction models for long-fiber thermoplastics (LFTs). These models were implemented in PNNL’s EMTA and EMTA-NLA codes. While EMTA is a standalone software for the computation of the composites thermoelastic properties, EMTA-NLA presents a series of nonlinear models implemented in ABAQUS® via user subroutines for structural analyses. In all these models, it is assumed that the fibers are linear elastic while the matrix material can exhibit a linear or typical nonlinear behavior depending on the loading prescribed to the composite. The key idea is to model the constitutive behavior of the matrix material and then to use an Eshelby-Mori-Tanaka approach (EMTA) combined with numerical techniques for fiber length and orientation distributions to determine the behavior of the as-formed composite. The basic property prediction models of EMTA and EMTA-NLA have been subject for implementation in the Autodesk® Moldflow® software packages. These models are the elastic stiffness model accounting for fiber length and orientation distributions, the fiber/matrix interface debonding model, and the elastic-plastic models. The PNNL elastic-plastic models for LFTs describes the composite nonlinear stress-strain response up to failure by an elastic-plastic formulation associated with either a micromechanical criterion to predict failure or a continuum damage mechanics formulation coupling damage to plasticity. All the models account for fiber length and orientation distributions as well as fiber/matrix debonding that can occur at any stage of loading. In an effort to transfer the technologies developed under the Predictive Engineering project to the American automotive and plastics industries, PNNL has obtained the approval of the DOE Office of Vehicle Technologies to provide Autodesk, Inc. with the technical support for the implementation of the basic property prediction models of EMTA and

  20. Stage distribution of breast cancer diagnosed before and after implementation of population-based mammographic screening

    International Nuclear Information System (INIS)

    Purpose: The German mammographic screening program is very similar to the Norwegian Breast Cancer Screening Program (NBCSP), which started about 10 years earlier. This study analyzes the stage distribution of invasive breast cancers diagnosed in the pre-screening and screening period, and evaluates the overall mortality in women aged 55 - 74 in the pilot and non-pilot counties of the NBCSP. Materials and Methods: The NBCSP invites women aged 50 - 69 to participate in two-view mammography biennially. Chi-square statistics were used to compare percentages of the stage and treatment of invasive breast cancers diagnosed in women residing in the four pilot counties in the pre-screening (1984 - 1995) and screening (1996 - 2007) period. An ecological approach was used to analyze the age-specific mortality in the pilot and non-pilot counties for the period 1970 - 2007. Results: 50 % of the breast cancers diagnosed in the pre-screening period, 70 % of the cases detected with screening, 43 % of the interval cancers, and 52 % of the cancers diagnosed outside the NBCSP were stage I. Stage III + was present in 11 % of the cancers in the pre-screening period, and in 1 % of the cancers detected with screening. In the screening period, the breast cancer mortality rate decreased substantially more in the pilot counties than in the non-pilot counties. Conclusion: The stage distribution of breast cancer diagnosed in the NBCSP is prognostically favorable compared to cancers diagnosed outside the screening program. The reduction in the breast cancer mortality rate was more pronounced in the four pilot counties compared to the non-pilot counties. It is necessary to evaluate the program based on individual data. (orig.)

  1. Role of the Technical Aspects of Hypofractionated Radiation Therapy Treatment of Prostate Cancer: A Review

    International Nuclear Information System (INIS)

    The increasing use of moderate (<35 fractions) and extreme (<5 fractions) hypofractionated radiation therapy in prostate cancer is yielding favorable results, both in terms of maintained biochemical response and toxicity. Several hypofractionation (HF) schemes for the treatment of prostate cancer are available, although there is considerable variability in the techniques used to manage intra-/interfraction motion and deliver radiation doses. We performed a review of the published studies on HF regimens as a topic of interest for the Stereotactic Ablative Radiotherapy working group, which is part of the Italian Association of Medical Physics. Aspects of organ motion management (imaging for contouring, target volume definition, and rectum/bladder preparation) and treatment delivery (prostate localization, image guided radiation therapy strategy and frequency) were evaluated and categorized to assess outcome relative to disease control and toxicity. Despite the heterogeneity of the data, some interesting trends that emerged from the review might be useful in identifying an optimum HF strategy

  2. Role of the Technical Aspects of Hypofractionated Radiation Therapy Treatment of Prostate Cancer: A Review

    Energy Technology Data Exchange (ETDEWEB)

    Clemente, Stefania, E-mail: clemente_stefania@libero.it [Istituto di Ricovero e Cura a Carattere Scientifico Centro di Riferimento Oncologico della Basilicata Rionero in Vulture, Potenza (Italy); Nigro, Roberta [Azienda Sanitaria Locale Rieti, Roma (Italy); Oliviero, Caterina [Istituto di Ricovero e Cura a Carattere Scientifico Centro di Riferimento Oncologico della Basilicata Rionero in Vulture, Potenza (Italy); Marchioni, Chiara [Azienda Sanitaria Locale Rieti, Roma (Italy); Esposito, Marco [Azienda Sanitaria, Firenze (Italy); Giglioli, Francesca Romana [Azienda Ospedaliera Città della Salute e della Scienza di Torino, Torino (Italy); Mancosu, Pietro [Humanitas Clinical and Research Hospital, Rozzano, Milano (Italy); Marino, Carmelo [Humanitas Centro Catanese di Oncologia, Catania (Italy); Russo, Serenella [Azienda Sanitaria, Firenze (Italy); Stasi, Michele [Azienda Ospedaliera Ordine Mauriziano di Torino, Torino (Italy); Strigari, Lidia [Istituto Nazionale Tumori Regina Elena, Roma (Italy); Veronese, Ivan [Universita' degli Studi di Milano, Milano (Italy); Landoni, Valeria [Istituto Nazionale Tumori Regina Elena, Roma (Italy)

    2015-01-01

    The increasing use of moderate (<35 fractions) and extreme (<5 fractions) hypofractionated radiation therapy in prostate cancer is yielding favorable results, both in terms of maintained biochemical response and toxicity. Several hypofractionation (HF) schemes for the treatment of prostate cancer are available, although there is considerable variability in the techniques used to manage intra-/interfraction motion and deliver radiation doses. We performed a review of the published studies on HF regimens as a topic of interest for the Stereotactic Ablative Radiotherapy working group, which is part of the Italian Association of Medical Physics. Aspects of organ motion management (imaging for contouring, target volume definition, and rectum/bladder preparation) and treatment delivery (prostate localization, image guided radiation therapy strategy and frequency) were evaluated and categorized to assess outcome relative to disease control and toxicity. Despite the heterogeneity of the data, some interesting trends that emerged from the review might be useful in identifying an optimum HF strategy.

  3. Radiotherapy Technical Considerations in the Management of Locally Advanced Pancreatic Cancer: American-French Consensus Recommendations

    Energy Technology Data Exchange (ETDEWEB)

    Huguet, Florence, E-mail: florence.huguet@tnn.aphp.fr [Department of Radiation Oncology, Tenon Hospital, APHP, University Paris VI, Paris (France); Goodman, Karyn A. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Azria, David [Department of Radiation Oncology, CRLC Val d' Aurelle-Paul Lamarque, Montpellier (France); Racadot, Severine [Department of Radiation Oncology, CRLC Leon Berard, Lyon (France); Abrams, Ross A. [Department of Radiation Oncology, Rush University Medical Center, Chicago, Illinois (United States)

    2012-08-01

    Summary: Pancreatic carcinoma is a leading cause of cancer-related mortality. Approximately 30% of pancreatic cancer patients present with locally advanced, unresectable nonmetastatic disease. For these patients, two therapeutic options exist: systemic chemotherapy or chemoradiotherapy. Within this context, the optimal technique for pancreatic irradiation is not clearly defined. A search to identify relevant studies was undertaken using the Medline database. All Phase III randomized trials evaluating the modalities of radiotherapy in locally advanced pancreatic cancer were included, as were some noncontrolled Phase II and retrospective studies. An expert panel convened with members of the Radiation Therapy Oncology Group and GERCOR cooperative groups to review identified studies and prepare the guidelines. Each member of the working group independently evaluated five endpoints: total dose, target volume definition, radiotherapy planning technique, dose constraints to organs at risk, and quality assurance. Based on this analysis of the literature, we recommend either three-dimensional conformal radiation therapy or intensity-modulated radiation therapy to a total dose of 50 to 54 Gy at 1.8 to 2 Gy per fraction. We propose gross tumor volume identification to be followed by an expansion of 1.5 to 2 cm anteriorly, posteriorly, and laterally, and 2 to 3 cm craniocaudally to generate the planning target volume. The craniocaudal margins can be reduced with the use of respiratory gating. Organs at risk are liver, kidneys, spinal cord, stomach, and small bowel. Stereotactic body radiation therapy should not be used for pancreatic cancer outside of clinical trials. Radiotherapy quality assurance is mandatory in clinical trials. These consensus recommendations are proposed for use in the development of future trials testing new chemotherapy combinations with radiotherapy. Not all of these recommendations will be appropriate for trials testing radiotherapy dose or dose

  4. Radiotherapy technical considerations in the management of locally advanced pancreatic cancer: American-French consensus recommendations.

    Science.gov (United States)

    Huguet, Florence; Goodman, Karyn A; Azria, David; Racadot, Severine; Abrams, Ross A

    2012-08-01

    Pancreatic carcinoma is a leading cause of cancer-related mortality. Approximately 30% of pancreatic cancer patients present with locally advanced, unresectable nonmetastatic disease. For these patients, two therapeutic options exist: systemic chemotherapy or chemoradiotherapy. Within this context, the optimal technique for pancreatic irradiation is not clearly defined. A search to identify relevant studies was undertaken using the Medline database. All Phase III randomized trials evaluating the modalities of radiotherapy in locally advanced pancreatic cancer were included, as were some noncontrolled Phase II and retrospective studies. An expert panel convened with members of the Radiation Therapy Oncology Group and GERCOR cooperative groups to review identified studies and prepare the guidelines. Each member of the working group independently evaluated five endpoints: total dose, target volume definition, radiotherapy planning technique, dose constraints to organs at risk, and quality assurance. Based on this analysis of the literature, we recommend either three-dimensional conformal radiation therapy or intensity-modulated radiation therapy to a total dose of 50 to 54 Gy at 1.8 to 2 Gy per fraction. We propose gross tumor volume identification to be followed by an expansion of 1.5 to 2 cm anteriorly, posteriorly, and laterally, and 2 to 3 cm craniocaudally to generate the planning target volume. The craniocaudal margins can be reduced with the use of respiratory gating. Organs at risk are liver, kidneys, spinal cord, stomach, and small bowel. Stereotactic body radiation therapy should not be used for pancreatic cancer outside of clinical trials. Radiotherapy quality assurance is mandatory in clinical trials. These consensus recommendations are proposed for use in the development of future trials testing new chemotherapy combinations with radiotherapy. Not all of these recommendations will be appropriate for trials testing radiotherapy dose or dose intensity

  5. 4D CT and lung cancer surgical resectability: a technical innovation

    International Nuclear Information System (INIS)

    A 74-year-old man presents with a left upper lobe lung adenocarcinoma, which demonstrated a wide base intimately with the aortic arch. We utilised 4D CT technique with a wide field of view CT unit to preoperatively determine likely surgical resectability. We propose that 4D CT may be of use in further investigating lung cancer with likely invasion of adjacent structures.

  6. Psychosocial Interventions for Families with Parental Cancer and Barriers and Facilitators to Implementation and Use – A Systematic Review

    Science.gov (United States)

    Inhestern, Laura; Haller, Anne-Catherine; Wlodarczyk, Olga; Bergelt, Corinna

    2016-01-01

    Background Parental cancer has a significant impact on minor children and families. Psychosocial interventions for affected families can provide support where necessary. This systematic review aims at providing an overview of existing interventions and support programs and focuses on the systematic investigation of barriers and facilitators for using psychosocial interventions for families affected by parental cancer (PROSPERO; registration number CRD42014013020). Methods A search of five electronic databases (EMBASE, MEDLINE, PsycInfo, Psyndex, CINAHL) was conducted in June 2014, and updated in September 2015. We included any kind of studies reporting psychosocial support services or interventions for families affected by parental cancer. Study quality was assessed using the Mixed Method Assessment Tool. Narrative synthesis and thematic analyses were undertaken to examine the included interventions and to identify barriers and facilitators for use and implementation. Results A total of 36 studies covering 19 interventions and support services were included in the systematic review. Interventions focused on children, parents or several family members and analyses revealed a broad picture of theoretical background and primary aims. Several studies focused on developmental or implementation phases or descriptions of interventions. Other included studies reported results of evaluations using qualitative and quantitative methods. Results suggest that interventions are helpful and that participants improved in various outcomes. The thematic analyses indicate that barriers for use of support services refer to aspects concerning the patients and families, such as practical difficulties, perceived need for support or fear of stigma. Cancer patients who understood the need and benefit of support services may have used them more often. Additionally, intervention characteristics such as a flexible structure and accessibility were important to reach families affected by

  7. Design and implementation of coded aperture coherent scatter spectral imaging of cancerous and healthy breast tissue samples.

    Science.gov (United States)

    Lakshmanan, Manu N; Greenberg, Joel A; Samei, Ehsan; Kapadia, Anuj J

    2016-01-01

    A scatter imaging technique for the differentiation of cancerous and healthy breast tissue in a heterogeneous sample is introduced in this work. Such a technique has potential utility in intraoperative margin assessment during lumpectomy procedures. In this work, we investigate the feasibility of the imaging method for tumor classification using Monte Carlo simulations and physical experiments. The coded aperture coherent scatter spectral imaging technique was used to reconstruct three-dimensional (3-D) images of breast tissue samples acquired through a single-position snapshot acquisition, without rotation as is required in coherent scatter computed tomography. We perform a quantitative assessment of the accuracy of the cancerous voxel classification using Monte Carlo simulations of the imaging system; describe our experimental implementation of coded aperture scatter imaging; show the reconstructed images of the breast tissue samples; and present segmentations of the 3-D images in order to identify the cancerous and healthy tissue in the samples. From the Monte Carlo simulations, we find that coded aperture scatter imaging is able to reconstruct images of the samples and identify the distribution of cancerous and healthy tissues (i.e., fibroglandular, adipose, or a mix of the two) inside them with a cancerous voxel identification sensitivity, specificity, and accuracy of 92.4%, 91.9%, and 92.0%, respectively. From the experimental results, we find that the technique is able to identify cancerous and healthy tissue samples and reconstruct differential coherent scatter cross sections that are highly correlated with those measured by other groups using x-ray diffraction. Coded aperture scatter imaging has the potential to provide scatter images that automatically differentiate cancerous and healthy tissue inside samples within a time on the order of a minute per slice. PMID:26962543

  8. Regional lymphadenectomy for gallbladder cancer: Rational extent, technical details, and patient outcomes

    Institute of Scientific and Technical Information of China (English)

    Yoshio Shirai; Toshifumi Wakai; Jun Sakata; Katsuyoshi Hatakeyama

    2012-01-01

    AIM:To define the rational extent of regional lymphadenectomy for gallbladder cancer and to clarify its effect on long-term survival.METHODS:A total of 152 patients with gallbladder cancer who underwent a minimum of "extended" portal lymph node dissection (defined as en bloc removal of the first- and second-echelon nodes) from 1982 to 2010 were retrospectively analyzed.Based on previous studies,regional lymph nodes of the gallbladder were divided into first-echelon nodes (cystic duct or pericholedochal nodes),second-echelon nodes (node groups posterosuperior to the head of the pancreas or around the hepatic vessels),and more distant nodes.RESULTS:Among the 152 patients (total of 3352 lymph nodes retrieved,median of 19 per patient),79 patients (52%) had 356 positive nodes.Among nodepositive patients,the prevalence of nodal metastasis was highest in the pericholedochal (54%) and cystic duct (38%) nodes,followed by the second-echelon node groups (29% to 19%),while more distant node groups were only rarely (5% or less) involved.Diseasespecific survival after R0 resection differed according to the nodal status (P < 0.001):most node-negative patients achieved long-term survival (median,not reached; 5-year survival,80%),whereas among nodepositive patients,22 survived for more than 5 years (median,37 mo; 5-year survival,43%).CONCLUSION:The rational extent of lymphadenectomy for gallbladder cancer should include the firstand second-echelon nodes.A considerable proportion of node-positive patients benefit from such aggressive lymphadenectomy.

  9. The New School-Based Learning (SBL) to Work-Based Learning (WBL) Transition Module: A Practical Implementation in the Technical and Vocational Education (TVE) System in Bahrain

    Science.gov (United States)

    Alseddiqi, M.; Mishra, R.; Pislaru, C.

    2012-05-01

    This paper diagnoses the implementation of a new engineering course entitled 'school-based learning (SBL) to work-based learning (WBL) transition module' in the Bahrain Technical and Vocational Education (TVE) learning environment. The module was designed to incorporate an innovative education and training approach with a variety of learning activities that are included in various learning case studies. Each case study was based on with learning objectives coupled with desired learning outcomes. The TVE students should meet the desired outcomes after the completion of the learning activities and assessments. To help with the implementation phase of the new module, the authors developed guidelines for each case study. The guidelines incorporated learning activities to be delivered in an integrated learning environment. The skills to be transferred were related to cognitive, affective, and technical proficiencies. The guidelines included structured instructions to help students during the learning process. In addition, technology was introduced to improve learning effectiveness and flexibility. The guidelines include learning indicators for each learning activity and were based on their interrelation with competencies to be achieved with respect to modern industrial requirements. Each learning indicator was then correlated against the type of learning environment, teaching and learning styles, examples of mode of delivery, and assessment strategy. Also, the learning activities were supported by technological features such as discussion forums for social perception and engagement and immediate feedback exercises for self-motivation. Through the developed module, TVE teachers can effectively manage the teaching and learning process as well as the assessment strategy to satisfy students' individual requirements and enable them to meet workplace requirements.

  10. Development, implementation and evaluation of a multidisciplinary cancer rehabilitation programme : The CANSURVIVOR Project : meeting post-treatment cancer survivors’ needs

    LENUS (Irish Health Repository)

    Ivers, Mary E.

    2009-01-01

    Cancer survivor numbers in Ireland are increasing due to the success of modern treatments. Although most survivors have a good quality of life not all survivors return to \\'normal\\' after treatment. The HSE funded CANSURVIVOR research project has found that many survivors have difficulties and need help to recover and adjust after cancer treatment. Over a number of exploratory studies using interviews, focus groups and a survey of 262 breast, prostate, colorectal and lung cancer survivors, the researchers found that over 25% of survivors experienced significant difficulties with physical, emotional and social functioning, including symptoms such as insomnia and fatigue, while 33% experienced high levels of anxiety. Of particular concern were the findings that over 50% of survivors were overweight, 35% had reduced their physical activity levels and 13% continued to smoke after cancer, putting them at risk for further health problems. This evidence led to the development of an 8-week multi-disciplinary pilot rehabilitation programme. Significant quality of life improvements were achieved with increases in strength and fitness as well as a reduction in anxiety levels and dietary improvements. The researchers highlight the need for a structured, co-ordinated survivorship service, education of health professionals about survivorship and the provision of high quality information to survivors. This research was led by the School of Psychology at UCD in collaboration with the Physiotherapy and Nutrition departments of St. Vincent\\'s hospital.

  11. Metformin and cancer: Technical and clinical implications for FDG-PET imaging

    Institute of Scientific and Technical Information of China (English)

    Selene; Capitanio; Cecilia; Marini; Gianmario; Sambuceti; Silvia; Morbelli

    2015-01-01

    Metformin is the most widely used hypoglycemic agent. Besides its conventional indications, increasing evidence demonstrate a potential efficacy of this biguanide as an anticancer drug. Possible mechanisms of actions seem to be independent from its hypoglycemic effect and seemto involve the interference with key pathways in cellular proliferation and glycolysis. To date, many clinical trials implying the use of metformin in cancer treatment are on-going. The increasing use of 18F-2-fluoro-2-deoxyd-glucose positron emission tomography(FDG-PET) in cancer evaluation raises a number of questions about the possible interference of the biguanide on FDG distribution. In particular, the interferences exerted by metformin on AMP-activated protein kinase pathway(the cellular energy sensor), on insulin levels and on Hexokinase could potentially have repercussion on glucose handling and thus on FDG distribution. A better comprehension of the impact of metformin on FDG uptake is needed in order to optimize the use of PET in this setting. This evaluation would be useful to ameliorate scans interpretation in diabetic patients under chronic metformin treatment and to critically interpret images in the context of clinical trials. Furthermore, collecting prospective data in this setting would help to verify whether FDG-PET could be a valid tool to appreciate the anticancer effect of this new therapeutic approach.

  12. Implementing an advanced waste separation step in an MBT plant: assessment of technical, economic and environmental impacts.

    Science.gov (United States)

    Meirhofer, Martina; Piringer, Gerhard; Rixrath, Doris; Sommer, Manuel; Ragossnig, Arne Michael

    2013-10-01

    Heavy fractions resulting from mechanical treatment stages of mechanical-biological waste treatment plants are posing very specific demands with regard to further treatment (large portions of inert and high-caloric components). Based on the current Austrian legal situation such a waste stream cannot be landfilled and must be thermally treated. The aim of this research was to evaluate if an inert fraction generated from this waste stream with advanced separation technologies, two sensor-based [near-infrared spectroscopy (NIR), X-ray transmission (XRT)] and two mechanical systems (wet and dry) is able to be disposed of. The performance of the treatment options for separation was evaluated by characterizing the resulting product streams with respect to purity and yield. Complementing the technical evaluation of the processing options, an assessment of the economic and global warming effects of the change in waste stream routing was conducted. The separated inert fraction was evaluated with regard to landfilling. The remaining high-caloric product stream was evaluated with regard to thermal utilization. The results show that, in principal, the selected treatment technologies can be used to separate high-caloric from inert components. Limitations were identified with regard to the product qualities achieved, as well as to the economic expedience of the treatment options. One of the sensor-based sorting systems (X-ray) was able to produce the highest amount of disposeable heavy fraction (44.1%), while having the lowest content of organic (2.0% C biogenic per kg waste input) components. None of the high-caloric product streams complied with the requirements for solid recovered fuels as defined in the Austrian Ordinance on Waste Incineration. The economic evaluation illustrates the highest specific treatment costs for the XRT (€ 23.15 per t), followed by the NIR-based sorting system (€ 15.67 per t), and the lowest costs for the air separation system (€ 10.79 per t

  13. Promoting Early Presentation of Breast Cancer in Older Women: Implementing an Evidence-Based Intervention in Routine Clinical Practice

    Directory of Open Access Journals (Sweden)

    Lindsay J. L. Forbes

    2012-01-01

    Full Text Available Background. Women over 70 with breast cancer have poorer one-year survival and present at a more advanced stage than younger women. Promoting early symptomatic presentation in older women may reduce stage cost effectively and is unlikely to lead to overdiagnosis. After examining efficacy in a randomised controlled trial, we piloted a brief health professional-delivered intervention to equip women to present promptly with breast symptoms, as an integral part of the final invited mammogram at age ~70, in the English National Health Service Breast Screening Programme. Methods. We trained mammographers, who then offered the intervention to older women in four breast screening services. We examined breast cancer awareness at baseline and one month in women receiving the intervention, and also in a service where the intervention was not offered. Results. We trained 27 mammographers to deliver the intervention confidently to a high standard. Breast cancer awareness increased 7-fold at one month in women receiving the intervention compared with 2-fold in the comparison service (odds ratio 15.2, 95% confidence interval 10.0 to 23.2. Conclusions. The PEP Intervention can be implemented in routine clinical practice with a potency similar to that achieved in a randomised controlled trial. It has the potential to reduce delay in diagnosis for breast cancer in older women.

  14. Breast Cancer Guidelines in Canada: A Review of Development and Implementation

    OpenAIRE

    Folkes, Amy; Urquhart, Robin; Zitzelsberger, Louise; Grunfeld, Eva

    2008-01-01

    A series of specific clinical practice guidelines (CPGs) were published in Canada in 1998. A primary objective of these ‘Clinical Practice Guidelines for the Care and Treatment of Breast Cancer’ was to decrease the variation in breast cancer care across the country. Prior to this, researchers found moderate compliance with consensus recommendations for breast cancer therapies in several Canadian provinces. However, a recent study concluded that the publication of the Canadian CPGs did not red...

  15. Issues Related to Implementing a Smoking Cessation Clinical Trial for Cancer Patients1

    OpenAIRE

    Martinez, Elisa; Tatum, Kristina L.; Weber, Dorothy M.; Kuzla, Natalie; Pendley, Anna B.S.; Campbell, Kirsten; Ridge, John A; Langer, Corey; Miyamoto, Curtis; Schnoll, Robert A.

    2008-01-01

    Given high rates of smoking among cancer patients, smoking cessation treatment is crucial, yet limited data exist to guide integration of such trials into the oncologic context. To determine the feasibility of conducting smoking cessation clinical trials with cancer patients, screening and baseline data from a large randomized placebo-controlled pharmacotherapy trial were analyzed. Descriptive statistics and regression analyses were used to compare enrollees to decliners, describe program enr...

  16. Technical challenges of sparing infrahyoid swallowing organs at risk in oropharynx squamous cell cancer treated with IMRT

    Energy Technology Data Exchange (ETDEWEB)

    Morley, Lyndon, E-mail: lyndon.morley@rmp.uhn.on.ca [Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario (Canada); Tsang, Shirley W.S. [Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario (Canada); Breen, Stephen L.; Waldron, John N. [Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario (Canada); Department of Radiation Oncology, University of Toronto, Toronto, Ontario (Canada); Maganti, Manjula; Pintilie, Melania [Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario (Canada); Dawson, Laura A.; Ringash, Jolie [Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario (Canada); Department of Radiation Oncology, University of Toronto, Toronto, Ontario (Canada); Huang, Shao Hui [Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario (Canada); Kim, John [Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario (Canada); Department of Radiation Oncology, University of Toronto, Toronto, Ontario (Canada)

    2014-07-01

    This study reports clinical performance in the sparing of infrahyoid swallowing organs at risk (SWOARs) in oropharynx cancer intensity-modulated radiation therapy (IMRT) plans. Rates of meeting dose-volume planning goals are reported and compared with geometry-based estimates of what is achievable. This study also develops 3 measures of target-SWOAR geometry and tests their usefulness in providing geometry-based dose-volume planning goals. A total of 50 oropharynx cancer IMRT plans were reviewed. Success rates in meeting institutional dose-volume goals were determined for the glottic larynx (G), postcricoid pharynx (P), and esophagus (E). The following 3 measures of target-SWOAR geometry were investigated as methods of identifying geometry-based planning goals: presence of gross disease in neck levels 3 to 4, target-SWOAR overlap, and a 3-dimensional (3D) measure of target-SWOAR geometry. Locally advanced disease was predominant in this patient population with target volumes overlapping SWOARs in 68% to 98% of cases. Clinical rates of success in meeting dose-volume goals varied by SWOAR (16% to 82%) but compared well with estimated potentially achievable rates in most cases (14% average difference between clinical and potential). Cases grouped by the presence of levels 3 to 4 neck nodes or target-SWOAR overlap did not have significantly different SWOAR doses. Cases grouped using a 3D measure of target-SWOAR geometry differed significantly, providing useful geometry-based planning goals (e.g., mean Glottis dose <45 Gy was achieved 19%, 44%, or 81% of the time in each of 3 groups). This study describes the technical challenge of sparing SWOARs and investigates several potential methods for grouping cases to assist with treatment plan evaluation. Quantifying the 3-D relationship between the targets and SWOARs is a promising way of approaching this complex problem. Data presented in this paper may be useful to evaluate treatment plans using objective geometry

  17. Technical factors associated with radiation pneumonitis after local ± regional radiation therapy for breast cancer

    International Nuclear Information System (INIS)

    Purpose: To assess the incidence of, and clinical factors associated with, symptomatic radiation pneumonitis (RP) after tangential breast/chest wall irradiation with or without regional lymph node treatment. Methods and Materials: The records of 613 patients irradiated with tangential photon fields for breast cancer with >6 months follow-up were reviewed. Clinically significant RP was defined as the presence of new pulmonary symptoms requiring steroids. Data on clinical factors previously reported to be associated with RP were collected, e.g., tamoxifen or chemotherapy exposure and age. The central lung distance (CLD) and the average of the superior and inferior mid lung distance (ALD) in the lateral tangential field were measured on simulator films as a surrogate for irradiated lung volume. Many patients were treated with partly wide tangential fields that included a heart block shielding a part of the lower lung. Results: RP developed in 15/613 (2.4%) patients. In the univariate analysis, there was an increased incidence of RP among patients treated with local-regional radiotherapy (RT) (4.1%) vs. those receiving local RT only (0.9%) (p=0.02), and among patients receiving chemotherapy (3.9%) vs. those not treated with chemotherapy (1.4%) (p=0.06). According to multivariate analysis, only the use of nodal RT remained independently associated with RP (p=0.03). There was no statistically significant association between ranked CLD or ALD measurements and RP among patients treated with nodal irradiation with tangential beams. However, there was a statistically nonsignificant trend for increasing rates of RP with grouped ALD values: below 2 cm (4% RP rate), between 2 and 3 cm (6%), and above 3 cm (14%). Conclusions: RP was an uncommon complication, both with local and local-regional RT. The addition of regional lymph node irradiation slightly increased the incidence of RP among patients treated with the partly wide tangential field technique. Concern for RP should

  18. Management Plan for Experimental Reintroduction of Sockeye into Skaha Lake; Proposed Implementation, Monitoring, and Evaluation, 2004 Technical Report.

    Energy Technology Data Exchange (ETDEWEB)

    Wright, Howie; Smith, Howard (Okanagan Nation Alliance, Fisheries Department, Westbank, BC, Canada)

    2004-01-01

    was largely supported but with the proviso that there should be a thorough evaluation and reporting of progress and results. A 2004 start on implementation and monitoring has now been proposed.

  19. Trends in breast cancer mortality in Sweden before and after implementation of mammography screening.

    Directory of Open Access Journals (Sweden)

    Jari Haukka

    Full Text Available BACKGROUND: Incidence-based mortality modelling comparing the risk of breast cancer death in screened and unscreened women in nine Swedish counties has suggested a 39% risk reduction in women 40 to 69 years old after introduction of mammography screening in the 1980s and 1990s. OBJECTIVE: We evaluated changes in breast cancer mortality in the same nine Swedish counties using a model approach based on official Swedish breast cancer mortality statistics, robust to effects of over-diagnosis and treatment changes. Using mortality data from the NordCan database from 1974 until 2003, we estimated the change in breast cancer mortality before and after introduction of mammography screening in at least the 13 years that followed screening start. RESULTS: Breast mortality decreased by 16% (95% CI: 9 to 22% in women 40 to 69, and by 11% (95% CI: 2 to 20% in women 40 to 79 years of age. DISCUSSION: Without individual data it is impossible to completely separate the effects of improved treatment and health service organisation from that of screening, which would bias our results in favour of screening. There will also be some contamination of post-screening mortality from breast cancer diagnosed prior to screening, beyond our attempts to adjust for delayed benefit. This would bias against screening. However, our estimates from publicly available data suggest considerably lower benefits than estimates based on comparison of screened versus non-screened women.

  20. Kootenai River White Sturgeon Recovery Implementation Plan and Schedule; 2005-2010, Technical Report 2004-2005.

    Energy Technology Data Exchange (ETDEWEB)

    Anders, Paul

    2007-03-01

    for maximum benefit. In an ideal world, specific recovery measures would be identified and implemented based on a series of complementary research investigations to definitively identify the proximate causes and specific mechanisms of recruitment failure. The acute status of Kootenai sturgeon and current inability to compartmentalize the complex ecosystem do not afford the luxury of time for exhaustive research studies on every potential mechanism of recruitment failure. Mechanistic studies cannot replace the need for experimental evaluations of implemented adaptive management experiments.

  1. Molecular markers for urothelial bladder cancer prognosis: Toward implementation in clinical practice

    NARCIS (Netherlands)

    Rhijn, B.W. van; Catto, J.W.; Goebell, P.J.; Knuchel, R.; Shariat, S.F.; Poel, H.G. van der; Sanchez-Carbayo, M.; Thalmann, G.N.; Schmitz-Drager, B.J.; Kiemeney, L.A.L.M.

    2014-01-01

    OBJECTIVES: To summarize the current status of clinicopathological and molecular markers for the prediction of recurrence or progression or both in non-muscle-invasive and survival in muscle-invasive urothelial bladder cancer, to address the reproducibility of pathology and molecular markers, and to

  2. Implementation of image-guided brachytherapy (IGBT) for patients with uterine cervix cancer: a tumor volume kinetics approach

    Science.gov (United States)

    Mendez, Lucas Castro; Stuart, Silvia Radwanski; Guimarães, Roger Guilherme Rodrigues; Ramos, Clarissa Cerchi Angotti; de Paula, Lucas Assad; de Sales, Camila Pessoa; Chen, André Tsin Chih; Blasbalg, Roberto; Baroni, Ronaldo Hueb

    2016-01-01

    Purpose To evaluate tumor shrinking kinetics in order to implement image-guided brachytherapy (IGBT) for the treatment of patients with cervix cancer. Material and methods This study has prospectively evaluated tumor shrinking kinetics of thirteen patients with uterine cervix cancer treated with combined chemoradiation. Four high dose rate brachytherapy fractions were delivered during the course of pelvic external beam radiation therapy (EBRT). Magnetic resonance imaging (MRI) exams were acquired at diagnosis (D), first (B1), and third (B3) brachytherapy fractions. Target volumes (GTV and HR-CTV) were calculated by both the ellipsoid formula (VE) and MRI contouring (VC), which were defined by a consensus between at least two radiation oncologists and a pelvic expert radiologist. Results Most enrolled patients had squamous cell carcinoma and FIGO stage IIB disease, and initiated brachytherapy after the third week of pelvic external beam radiation. Gross tumor volume volume reduction from diagnostic MRI to B1 represented 61.9% and 75.2% of the initial volume, when measured by VE and VC, respectively. Only a modest volume reduction (15-20%) was observed from B1 to B3. Conclusions The most expressive tumor shrinking occurred in the first three weeks of oncological treatment and was in accordance with gynecological examination. These findings may help in IGBT implementation. PMID:27648083

  3. The validation and clinical implementation of BRCAplus: a comprehensive high-risk breast cancer diagnostic assay.

    Directory of Open Access Journals (Sweden)

    Hansook Kim Chong

    Full Text Available Breast cancer is the most commonly diagnosed cancer in women, with 10% of disease attributed to hereditary factors. Although BRCA1 and BRCA2 account for a high percentage of hereditary cases, there are more than 25 susceptibility genes that differentially impact the risk for breast cancer. Traditionally, germline testing for breast cancer was performed by Sanger dideoxy terminator sequencing in a reflexive manner, beginning with BRCA1 and BRCA2. The introduction of next-generation sequencing (NGS has enabled the simultaneous testing of all genes implicated in breast cancer resulting in diagnostic labs offering large, comprehensive gene panels. However, some physicians prefer to only test for those genes in which established surveillance and treatment protocol exists. The NGS based BRCAplus test utilizes a custom tiled PCR based target enrichment design and bioinformatics pipeline coupled with array comparative genomic hybridization (aCGH to identify mutations in the six high-risk genes: BRCA1, BRCA2, PTEN, TP53, CDH1, and STK11. Validation of the assay with 250 previously characterized samples resulted in 100% detection of 3,025 known variants and analytical specificity of 99.99%. Analysis of the clinical performance of the first 3,000 BRCAplus samples referred for testing revealed an average coverage greater than 9,000X per target base pair resulting in excellent specificity and the sensitivity to detect low level mosaicism and allele-drop out. The unique design of the assay enabled the detection of pathogenic mutations missed by previous testing. With the abundance of NGS diagnostic tests being released, it is essential that clinicians understand the advantages and limitations of different test designs.

  4. Impact of learning curve and technical changes on dosimetry in low-dose brachytherapy for prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Le Fur, E. [CHU Brest (France). Radiation Therapy Dept.; Universite de Bretagne Occidentale, Brest (France). Faculte de Medecine et des Sciences de la Sante; Malhaire, J.P.; Baverez, D.; Schlurmann, F. [CHU Brest (France). Radiation Therapy Dept.; Delage, F.; Perrouin-Verbe, M.A. [CHU Brest (France). Urology Dept.; Guerif, S. [University Hospital La Miletrie, Poitiers (France). Radiation Therapy Dept.; Poitiers Univ. (France); Fournier, G.; Valeri, A. [CHU Brest (France). Urology Dept.; Universite de Bretagne Occidentale, Brest (France). Faculte de Medecine et des Sciences de la Sante; Universite Europeenne de Bretagne, Rennes (France); APHP, Hopital Tenon, Paris (France). CeRe.PP; Pradier, O. [CHU Brest (France). Radiation Therapy Dept.; Universite de Bretagne Occidentale, Brest (France). Faculte de Medecine et des Sciences de la Sante; Universite Europeenne de Bretagne, Rennes (France); CHU Brest (France). LaTIM, INSERM U650

    2012-12-15

    Purpose: To assess the impact of experience and technical changes on peri- and postimplantation (1 month later) dosimetry for permanent prostate brachytherapy (PPB). Patients and methods: From July 2003 to May 2010, 150 prostate cancer patients underwent low-dose, loose-seed I{sup 125} PPB as monotherapy with intraoperative planning. Patients were divided into three groups - P1 (n = 64), P2 (n = 45), P3 (n = 41) - according to the technical changes that occurred during the study period: use of an automatic stepper at the beginning of P2 and a high-frequency ultrasound probe in P3. Peri- and postimplantation dosimetric parameters (on day 30) were reported: D90 (dose received by 90% of prostate volume), V100 and V150 (prostate volume receiving, respectively, 100% and 150% of the prescribed dose), D2 cc and D0.1 cc (doses received by 2 cc and 0.1 cc of the rectum), R100 (rectum volume that received 100% of the prescribed dose), and D10 and D30 (doses received by 10% and 30% of the urethra, only during peri-implantation). Results: We observed a decrease in the number of needles and seeds used over time. The mean peri-implantation D90 was 187.52 Gy without a significant difference between the three periods (p = 0.48). The postimplantation D90, V100, and V150 parameters were, respectively, 168.3 Gy, 91.9%, and 55% with no significant difference between the three periods. The peri-implantation and postimplantation D0.1 cc and R100 significantly decreased over time; on day 30: D0.1 cc P1 = 223.1 Gy vs. D0.1 cc P3 = 190.4 Gy (p = 8.10- 5) and R100 P1 = 1.06 cc vs. R100 P3 = 0.53 cc (p = 0.0008). Conclusion: We observed a learning curve for the implantation parameters, which led to a significant decrease in the rectal doses without having any impact on the prostate dosimetric parameters. (orig.)

  5. Impact of learning curve and technical changes on dosimetry in low-dose brachytherapy for prostate cancer

    International Nuclear Information System (INIS)

    Purpose: To assess the impact of experience and technical changes on peri- and postimplantation (1 month later) dosimetry for permanent prostate brachytherapy (PPB). Patients and methods: From July 2003 to May 2010, 150 prostate cancer patients underwent low-dose, loose-seed I125 PPB as monotherapy with intraoperative planning. Patients were divided into three groups - P1 (n = 64), P2 (n = 45), P3 (n = 41) - according to the technical changes that occurred during the study period: use of an automatic stepper at the beginning of P2 and a high-frequency ultrasound probe in P3. Peri- and postimplantation dosimetric parameters (on day 30) were reported: D90 (dose received by 90% of prostate volume), V100 and V150 (prostate volume receiving, respectively, 100% and 150% of the prescribed dose), D2 cc and D0.1 cc (doses received by 2 cc and 0.1 cc of the rectum), R100 (rectum volume that received 100% of the prescribed dose), and D10 and D30 (doses received by 10% and 30% of the urethra, only during peri-implantation). Results: We observed a decrease in the number of needles and seeds used over time. The mean peri-implantation D90 was 187.52 Gy without a significant difference between the three periods (p = 0.48). The postimplantation D90, V100, and V150 parameters were, respectively, 168.3 Gy, 91.9%, and 55% with no significant difference between the three periods. The peri-implantation and postimplantation D0.1 cc and R100 significantly decreased over time; on day 30: D0.1 cc P1 = 223.1 Gy vs. D0.1 cc P3 = 190.4 Gy (p = 8.10- 5) and R100 P1 = 1.06 cc vs. R100 P3 = 0.53 cc (p = 0.0008). Conclusion: We observed a learning curve for the implantation parameters, which led to a significant decrease in the rectal doses without having any impact on the prostate dosimetric parameters. (orig.)

  6. Readiness and capacity of librarians in public libraries to implement a breast cancer outreach and screening campaign in medically underserved communities.

    Science.gov (United States)

    Goytia, Elliott J; Rapkin, Bruce; Weiss, Elisa S; Golub, David; Guzman, Vivian; O'Connor, Maureen

    2005-11-01

    Community-based partnerships are an important means of addressing cancer health disparities in medically underserved communities. Public libraries may be ideal partners in this effort. To assess the readiness and capacity of a public library system to implement cancer recruitment and outreach campaigns, 58 librarians in the Queens Borough Public Library System in New York completed self-administered questionnaires before and after a training on breast health, cancer, and screening. Results indicate that they are interested in participating in a cancer outreach campaign and feel it is a critical need in their community. Many librarians lacked the knowledge about cancer and cancer information resources needed to participate optimally. Nevertheless, librarians provide a cultural bridge to medically underserved communities. Partnering with a public library system to improve access to care has great potential, yet a number of challenges need to be overcome.

  7. The biological and clinical effects of smoking by patients with cancer and strategies to implement evidence-based tobacco cessation support.

    Science.gov (United States)

    Warren, Graham W; Sobus, Samantha; Gritz, Ellen R

    2014-11-01

    Tobacco use is an established risk factor for the development of several cancers; however, far less work has been done to understand the effects of continued smoking on cancer treatment outcomes, and structured tobacco cessation efforts are not well incorporated into the standard care for patients with cancer. In this Review we discuss the known biological effects of smoking on cancer cell biology and emphasise the clinical effects of continued smoking in patients with cancer treated with chemotherapy or radiotherapy. Although evidence supports the need for inclusion of dedicated tobacco cessation efforts for patients with cancer, clinicians should consider the methods used to provide evidence-based tobacco cessation support and the available resources to deliver and maintain consistent tobacco cessation support. We also address the variables to consider in the design and implementation of a sustainable tobacco cessation programme. PMID:25439699

  8. Technical and economic analysis of implementation of small scale GTL (Gas-to-Liquids) technology to monetize associated stranded natural gas offshore in Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Castelo Branco, David; Szklo, Alexandre; Schaeffer, Roberto [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia (COPPE). Programa de Planejamento Energetico

    2008-07-01

    The volume of global stranded natural gas reserves is impressive totalling more than a third of the world's proven natural gas reserves. In Brazil, recent discoveries operated by PETROBRAS with the share of other companies indicate the tendency of incorporating stranded gas reserves (associated or not) to the country's total reserves. The objective of this study is to perform a technical and economic analysis of the implementation of small-scale GTL technology for the exploitation of stranded associated natural gas offshore in Brazil. Thus, the study initially held a survey of the processes of gasification and the manufacturers of technologies and projects based on these processes, specifically for offshore applications. Then, the offshore environment conditions were examined. After the confrontation of the available technologies and the operational conditions, one technology was chosen to be assessed by the economic analysis. The results show that GTL offshore option becomes feasible for the minimum oil price of approximately $50.00 per barrel. This price is greater than the value of robustness adopted by PETROBRAS, however there is still the possibility of cost reductions for the feasibility of new technologies. (author)

  9. The FAO/NACA Asia Regional Technical Guidelines on Health Management for the Responsible Movement of Live Aquatic Animals: lessons learned from their development and implementation.

    Science.gov (United States)

    Subasinghe, R P; Bondad-Reantaso, M G

    2008-04-01

    Aquaculture is the fastest growing food producing sector in the world and it is expected to produce significant quantities of fish in the coming years to meet the growing global demand for aquatic animal products. The expansion and diversification of the sector, along with globalisation and trade liberalisation have resulted in aquatic animals and animal products moving around the world rapidly, causing serious disease outbreaks stemming from incursions of pathogens through unregulated transboundary movements. It has become necessary to develop appropriate guidelines for establishing national regulatory frameworks to improve responsibility in transboundary movement of live aquatic animals. In 2000, the Food and Agriculture Organization of the United Nations (FAO), in collaboration with the Network of Aquaculture Centres in Asia-Pacific (NACA) and in partnership with 21 Asian countries, developed the Asia Regional Technical Guidelines on Health Management for the Responsible Movement of Live Aquatic Animals. The present article outlines the development process of the guidelines, the lessons learned from their implementation at national level and the way forward. PMID:18666478

  10. Evaluation of Sexual and Urinary Function After Implementation of Robot-assisted Surgery for Rectal Cancer

    DEFF Research Database (Denmark)

    Schmiegelow, Amalie F T; Broholm, Malene; Gögenur, Ismail;

    2016-01-01

    was measured with validated questionnaires and the results were statistically analyzed. RESULTS: A total of 97 questionnaires were included in the study. Of those sexually active before the operation, 81% reported some degree of erectile dysfunction (ED). In total, 73% reported some degree of orgasmic......PURPOSE: Our objective was to report postoperative urogenital dysfunction after rectal cancer surgery, identifying possible predictors including conventional laparoscopic total mesorectal excision and robot-assisted total mesorectal excision laparoscopic surgery. MATERIALS AND METHODS......: Questionnaires were mailed to 184 patients who underwent laparoscopic rectal cancer surgery between January 2009 and May 2013. Single questions were used to retrospectively assess preoperative urogenital dysfunction. Surgical data were collected from hospital records. Postoperative urinary and sexual function...

  11. Implementation and Quality Control of Lung Cancer EGFR Genetic Testing by MALDI-TOF Mass Spectrometry in Taiwan Clinical Practice

    Science.gov (United States)

    Su, Kang-Yi; Kao, Jau-Tsuen; Ho, Bing-Ching; Chen, Hsuan-Yu; Chang, Gee-Cheng; Ho, Chao-Chi; Yu, Sung-Liang

    2016-01-01

    Molecular diagnostics in cancer pharmacogenomics is indispensable for making targeted therapy decisions especially in lung cancer. For routine clinical practice, the flexible testing platform and implemented quality system are important for failure rate and turnaround time (TAT) reduction. We established and validated the multiplex EGFR testing by MALDI-TOF MS according to ISO15189 regulation and CLIA recommendation in Taiwan. Totally 8,147 cases from Aug-2011 to Jul-2015 were assayed and statistical characteristics were reported. The intra-run precision of EGFR mutation frequency was CV 2.15% (L858R) and 2.77% (T790M); the inter-run precision was CV 3.50% (L858R) and 2.84% (T790M). Accuracy tests by consensus reference biomaterials showed 100% consistence with datasheet (public database). Both analytical sensitivity and specificity were 100% while taking Sanger sequencing as the gold-standard method for comparison. EGFR mutation frequency of peripheral blood mononuclear cell for reference range determination was 0.002 ± 0.016% (95% CI: 0.000–0.036) (L858R) and 0.292 ± 0.289% (95% CI: 0.000–0.871) (T790M). The average TAT was 4.5 working days and the failure rate was less than 0.1%. In conclusion, this study provides a comprehensive report of lung cancer EGFR mutation detection from platform establishment, method validation to clinical routine practice. It may be a reference model for molecular diagnostics in cancer pharmacogenomics. PMID:27480787

  12. Implementation of mass media community health education: the Forsyth County Cervical Cancer Prevention Project.

    Science.gov (United States)

    Dignan, M; Bahnson, J; Sharp, P; Beal, P; Smith, M; Michielutte, R

    1991-09-01

    The Forsyth County Cervical Cancer Prevention Project (FCP) is a community-based health education project funded by the National Cancer Institute. The target population includes around 25 000 black women age 18 and older who reside in Forsyth County, North Carolina. The overall goal of the program is to prevent mortality from cervical cancer by promoting Pap smears and return for follow-up care when needed. Based on the principles of social marketing, a plan to reach the target population with mass media educational messages through electronic and print channels was developed. Guided by marketing objectives, the target population was divided into relatively discrete segments. The segments included church attenders, patients in waiting rooms of public and selected health providers, female students at local colleges, shoppers, viewers of radio and television, newspaper readers, and business owners and managers. Introduction of the program was based on strategies developed for reaching the target population in each segment with television, radio and print mass media messages. Qualitative assessment of the mass media developed by the program indicated that all forms of communication helped to increase awareness of the program. PMID:10148691

  13. Dosimetric and technical aspects of intraoperative I-125 brachytherapy for stage I non-small cell lung cancer

    International Nuclear Information System (INIS)

    Initial treatment outcome data from our institution for stage I non-small cell lung cancer (NSCLC) patients have shown that sublobar resection in combination with iodine-125 (I-125) brachytherapy is associated with recurrence rates of 2.0%, compared to 18.6% with sublobar resection alone. In this work, the technical and dosimetric aspects required to execute this procedure from the radiation oncology perspective as well as an analysis of the dose distributions of patients treated with this technique are presented. In this treatment technique, I-125 seeds in vicryl suture are embedded into vicryl mesh and surgically inserted providing a 2.0 cm margin on each side of the resection staple line. A nomogram is developed to determine the suture spacing in the vicryl mesh, as a function of seed activity in order to deliver 120 Gy at a distance of 0.5 cm above and below the seed array. Post-operative dosimetry consists of a CT-based planning and dose volume analysis. Dose distributions, dose volume histograms and mean dose data for lung are analysed in a group of patients. Dosimetric results show significant lung sparing with only a small volume of lung irradiated for all patients with mean lung dose values ranging from 1.5 Gy to 5.4 Gy. Lung brachytherapy with I-125 at the time of sublobar resection is a highly conformal option of dose delivery for stage I NSCLC patients with compromised physiologic reserve. Patient-related toxicity clinically measured by loss of pulmonary function and radiation-induced pneumonitis have not been linked to this procedure

  14. Dosimetric and technical aspects of intraoperative I-125 brachytherapy for stage I non-small cell lung cancer

    Science.gov (United States)

    Johnson, Mark; Colonias, Athanasios; Parda, David; Trombetta, Mark; Gayou, Olivier; Reitz, Bodo; Miften, Moyed

    2007-03-01

    Initial treatment outcome data from our institution for stage I non-small cell lung cancer (NSCLC) patients have shown that sublobar resection in combination with iodine-125 (I-125) brachytherapy is associated with recurrence rates of 2.0%, compared to 18.6% with sublobar resection alone. In this work, the technical and dosimetric aspects required to execute this procedure from the radiation oncology perspective as well as an analysis of the dose distributions of patients treated with this technique are presented. In this treatment technique, I-125 seeds in vicryl suture are embedded into vicryl mesh and surgically inserted providing a 2.0 cm margin on each side of the resection staple line. A nomogram is developed to determine the suture spacing in the vicryl mesh, as a function of seed activity in order to deliver 120 Gy at a distance of 0.5 cm above and below the seed array. Post-operative dosimetry consists of a CT-based planning and dose volume analysis. Dose distributions, dose volume histograms and mean dose data for lung are analysed in a group of patients. Dosimetric results show significant lung sparing with only a small volume of lung irradiated for all patients with mean lung dose values ranging from 1.5 Gy to 5.4 Gy. Lung brachytherapy with I-125 at the time of sublobar resection is a highly conformal option of dose delivery for stage I NSCLC patients with compromised physiologic reserve. Patient-related toxicity clinically measured by loss of pulmonary function and radiation-induced pneumonitis have not been linked to this procedure.

  15. Dosimetric and technical aspects of intraoperative I-125 brachytherapy for stage I non-small cell lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Mark [Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212 (United States); Colonias, Athanasios [Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212 (United States); Parda, David [Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212 (United States); Trombetta, Mark [Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212 (United States); Gayou, Olivier [Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212 (United States); Reitz, Bodo [Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212 (United States); Miften, Moyed [Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212 (United States)

    2007-03-07

    Initial treatment outcome data from our institution for stage I non-small cell lung cancer (NSCLC) patients have shown that sublobar resection in combination with iodine-125 (I-125) brachytherapy is associated with recurrence rates of 2.0%, compared to 18.6% with sublobar resection alone. In this work, the technical and dosimetric aspects required to execute this procedure from the radiation oncology perspective as well as an analysis of the dose distributions of patients treated with this technique are presented. In this treatment technique, I-125 seeds in vicryl suture are embedded into vicryl mesh and surgically inserted providing a 2.0 cm margin on each side of the resection staple line. A nomogram is developed to determine the suture spacing in the vicryl mesh, as a function of seed activity in order to deliver 120 Gy at a distance of 0.5 cm above and below the seed array. Post-operative dosimetry consists of a CT-based planning and dose volume analysis. Dose distributions, dose volume histograms and mean dose data for lung are analysed in a group of patients. Dosimetric results show significant lung sparing with only a small volume of lung irradiated for all patients with mean lung dose values ranging from 1.5 Gy to 5.4 Gy. Lung brachytherapy with I-125 at the time of sublobar resection is a highly conformal option of dose delivery for stage I NSCLC patients with compromised physiologic reserve. Patient-related toxicity clinically measured by loss of pulmonary function and radiation-induced pneumonitis have not been linked to this procedure.

  16. Implementation of mechanism of action biology-driven early drug development for children with cancer.

    Science.gov (United States)

    Pearson, Andrew D J; Herold, Ralf; Rousseau, Raphaël; Copland, Chris; Bradley-Garelik, Brigid; Binner, Debbie; Capdeville, Renaud; Caron, Hubert; Carleer, Jacqueline; Chesler, Louis; Geoerger, Birgit; Kearns, Pamela; Marshall, Lynley V; Pfister, Stefan M; Schleiermacher, Gudrun; Skolnik, Jeffrey; Spadoni, Cesare; Sterba, Jaroslav; van den Berg, Hendrick; Uttenreuther-Fischer, Martina; Witt, Olaf; Norga, Koen; Vassal, Gilles

    2016-07-01

    An urgent need remains for new paediatric oncology drugs to cure children who die from cancer and to reduce drug-related sequelae in survivors. In 2007, the European Paediatric Regulation came into law requiring industry to create paediatric drug (all types of medicinal products) development programmes alongside those for adults. Unfortunately, paediatric drug development is still largely centred on adult conditions and not a mechanism of action (MoA)-based model, even though this would be more logical for childhood tumours as these have much fewer non-synonymous coding mutations than adult malignancies. Recent large-scale sequencing by International Genome Consortium and Paediatric Cancer Genome Project has further shown that the genetic and epigenetic repertoire of driver mutations in specific childhood malignancies differs from more common adult-type malignancies. To bring about much needed change, a Paediatric Platform, ACCELERATE, was proposed in 2013 by the Cancer Drug Development Forum, Innovative Therapies for Children with Cancer, the European Network for Cancer Research in Children and Adolescents and the European Society for Paediatric Oncology. The Platform, comprising multiple stakeholders in paediatric oncology, has three working groups, one with responsibility for promoting and developing high-quality MoA-informed paediatric drug development programmes, including specific measures for adolescents. Key is the establishment of a freely accessible aggregated database of paediatric biological tumour drug targets to be aligned with an aggregated pipeline of drugs. This will enable prioritisation and conduct of early phase clinical paediatric trials to evaluate these drugs against promising therapeutic targets and to generate clinical paediatric efficacy and safety data in an accelerated time frame. Through this work, the Platform seeks to ensure that potentially effective drugs, where the MoA is known and thought to be relevant to paediatric

  17. Adherence to guidelines on cervical cancer screening in general practice : programme elements of successful implementation

    NARCIS (Netherlands)

    Hermens, R P; Hak, E; Hulscher, M E; Braspenning, J C; Grol, R P

    2001-01-01

    BACKGROUND: There is still only limited understanding of whether and why interventions to facilitate the implementation of guidelines for improving primary care are successful. It is therefore important to look inside the 'black box' of the intervention, to ascertain which elements work well or less

  18. Implementation of an Early Warning Scoring System to Identify Patients With Cancer at Risk for Deterioration.

    Science.gov (United States)

    Olsen, MiKaela; Mooney, Kathy; Evans, Ellen

    2016-08-01

    Early warning scoring systems are tools for nurses to help monitor their patients and improve how quickly a patient experiencing a sudden decline receives clinical care. Nurse leaders and frontline staff at a major academic medical center implemented a new early warning system that gives clear guidelines to nurses, nursing assistants, and other clinicians about vital-sign parameters and changes in patients' mental status. 
. PMID:27441509

  19. 银医自助管理平台功能的技术实现%Technical Implementation of Bank-Hospital self-service Management Platform

    Institute of Scientific and Technical Information of China (English)

    袁荣江; 潘晓雷; 薛宁

    2012-01-01

    Described in detail the function of the Bank-Medicalself— management platform, including: self-service terminal device monitoring, statistical reporting, the Quartet Reconciliation, user rights management, and system log management, provider of equipment management, equipment management, system version control. On this basis, on the Bank-Medical self—management platform, system design and implementation, as well as the effectiveness of the final.The author is a senior technical manager, has for many years engaged in banking, hospital HIS system development experience. This article describes the Bank—Medicalself— management platform independent research and development of the card Electronic Co., Ltd., Shenzhen City. Take full account of the versatility of the system and the banking system, rigor, security system design and development process; mainstream techniques, under the premise to meet customer needs, taking into account considering the maintainability of the system.%通过介绍“银医自助管理平台”的功能,技术实现及应用成效,说明银医自助管理平台在银医自助服务平台中发挥的重要作用.详细介绍了银医自助管理平台的功能,在此基础上,阐述了银医自助管理平台的系统设计及其实现,以及最终所取得的成效.在系统的设计开发过程中,充分考虑了系统的通用性和银行系统的严谨性、安全性;采用了主流技术,在满足客户需求的前提下,同时兼顾考虑系统的可维护性.

  20. Technical implementation plan for the ShakeAlert production system: an Earthquake Early Warning system for the West Coast of the United States

    Science.gov (United States)

    Given, Douglas D.; Cochran, Elizabeth S.; Heaton, Thomas; Hauksson, Egill; Allen, Richard; Hellweg, Peggy; Vidale, John; Bodin, Paul

    2014-01-01

    Earthquake Early Warning (EEW) systems can provide as much as tens of seconds of warning to people and automated systems before strong shaking arrives. The United States Geological Survey (USGS) and its partners are developing such an EEW system, called ShakeAlert, for the West Coast of the United States. This document describes the technical implementation of that system, which leverages existing stations and infrastructure of the Advanced National Seismic System (ANSS) regional networks to achieve this new capability. While significant progress has been made in developing the ShakeAlert early warning system, improved robustness of each component of the system and additional testing and certification are needed for the system to be reliable enough to issue public alerts. Major components of the system include dense networks of ground motion sensors, telecommunications from those sensors to central processing systems, algorithms for event detection and alert creation, and distribution systems to alert users. Capital investment costs for a West Coast EEW system are projected to be $38.3M, with additional annual maintenance and operations totaling $16.1M—in addition to current ANSS expenditures for earthquake monitoring. An EEW system is complementary to, but does not replace, other strategies to mitigate earthquake losses. The system has limitations: false and missed alerts are possible, and the area very near to an earthquake epicenter may receive little or no warning. However, such an EEW system would save lives, reduce injuries and damage, and improve community resilience by reducing longer-term economic losses for both public and private entities.

  1. Expected treatment dose construction and adaptive inverse planning optimization: Implementation for offline head and neck cancer adaptive radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Yan Di; Liang Jian [Department of Radiation Oncology, Beaumont Health System, Royal Oak, Michigan 48073 (United States)

    2013-02-15

    : Adaptive treatment modification can be implemented including the expected treatment dose in the adaptive inverse planning optimization. The retrospective evaluation results demonstrate that utilizing the weekly adaptive inverse planning optimization, the dose distribution of h and n cancer treatment can be largely improved.

  2. An evaluation system for electronic retrospective analyses in radiation oncology: implemented exemplarily for pancreatic cancer

    Science.gov (United States)

    Kessel, Kerstin A.; Jäger, Andreas; Bohn, Christian; Habermehl, Daniel; Zhang, Lanlan; Engelmann, Uwe; Bougatf, Nina; Bendl, Rolf; Debus, Jürgen; Combs, Stephanie E.

    2013-03-01

    To date, conducting retrospective clinical analyses is rather difficult and time consuming. Especially in radiation oncology, handling voluminous datasets from various information systems and different documentation styles efficiently is crucial for patient care and research. With the example of patients with pancreatic cancer treated with radio-chemotherapy, we performed a therapy evaluation by using analysis tools connected with a documentation system. A total number of 783 patients have been documented into a professional, web-based documentation system. Information about radiation therapy, diagnostic images and dose distributions have been imported. For patients with disease progression after neoadjuvant chemoradiation, we designed and established an analysis workflow. After automatic registration of the radiation plans with the follow-up images, the recurrence volumes are segmented manually. Based on these volumes the DVH (dose-volume histogram) statistic is calculated, followed by the determination of the dose applied to the region of recurrence. All results are stored in the database and included in statistical calculations. The main goal of using an automatic evaluation system is to reduce time and effort conducting clinical analyses, especially with large patient groups. We showed a first approach and use of some existing tools, however manual interaction is still necessary. Further steps need to be taken to enhance automation. Already, it has become apparent that the benefits of digital data management and analysis lie in the central storage of data and reusability of the results. Therefore, we intend to adapt the evaluation system to other types of tumors in radiation oncology.

  3. Evaluation of modular education program implementation in vocational and technical high schools Mesleki ve teknik liselerde uygulanan modüler öğretim programının değerlendirilmesi

    OpenAIRE

    Subhan Ekşioğlu; Mehmet Taşpınar

    2014-01-01

    The aim of this study is to evaluate the modular educational program implemented at vocational high schools and to describe the problems in this program. The study is based on the Erden’s Evaluation Model Regarding Curriculum Components. The model of the study is descriptive study. The data were gathered through two different models by using three different sources: The quantitative data were collected from 430 teachers and 903 students at 48 vocational and technical high schools in Turkey. T...

  4. CANCER

    Directory of Open Access Journals (Sweden)

    N. Kavoussi

    1973-09-01

    Full Text Available There are many carcinogenetic elements in industry and it is for this reason that study and research concerning the effect of these materials is carried out on a national and international level. The establishment and growth of cancer are affected by different factors in two main areas:-1 The nature of the human or animal including sex, age, point and method of entry, fat metabolism, place of agglomeration of carcinogenetic material, amount of material absorbed by the body and the immunity of the body.2 The different nature of the carcinogenetic material e.g. physical, chemical quality, degree of solvency in fat and purity of impurity of the element. As the development of cancer is dependent upon so many factors, it is extremely difficult to determine whether a causative element is principle or contributory. Some materials are not carcinogenetic when they are pure but become so when they combine with other elements. All of this creates an industrial health problem in that it is almost impossible to plan an adequate prevention and safety program. The body through its system of immunity protects itself against small amounts of carcinogens but when this amount increases and reaches a certain level the body is not longer able to defend itself. ILO advises an effective protection campaign against cancer based on the Well –equipped laboratories, Well-educated personnel, the establishment of industrial hygiene within factories, the regular control of safety systems, and the implementation of industrial health principles and research programs.

  5. The implement and execution effect of technical marketing in integrated iron and steel works%现代钢铁企业技术营销实施与效果

    Institute of Scientific and Technical Information of China (English)

    龙益林

    2009-01-01

    Technical marketing in integrated iron and steel works is defined. Characteristic of steel works and implementation and execution effect of technical marketing are analyzed in the paper.Integrated iron and steel works must establish a fairly complete technical marketing system,and train first-class technical and marketing eomposite personnel, and keep technical innovation continuously and consistently, and stabilize and prove products quality for their beneficial competition in the steel market today.%文章对钢铁企业的技术营销进行了定义,对钢铁企业的自身特点、技术营销的实施与取得的效果进行了分析,指出钢铁企业在当今的市场竞争中要立于不败之地.就要建立完整的技术营销体系,培养出优秀的技术营销型复合人才,保持技术创新的一贯性和连续性,稳定和提升产品质量.

  6. The socio-technical organisation of community pharmacies as a factor in the Electronic Prescription Service Release Two implementation: a qualitative study

    Directory of Open Access Journals (Sweden)

    Harvey Jasmine

    2012-12-01

    Full Text Available Abstract Background The introduction of a new method of transmitting prescriptions from general practices to community pharmacies in England (Electronic Prescription Service Release 2 (EPS2 has generated debate on how it will change work practice. As EPS2 will be a key technical element in dispensing, we reviewed the literature to find that there were no studies on how social and technical elements come together to form work practice in community pharmacies. This means the debate has little point of reference. Our aim therefore was to study the ways social and technical elements of a community pharmacy are used to achieve dispensing through the development of a conceptual model on pharmacy work practice, and to consider how a core technical element such the EPS2 could change work practice. Method We used ethnographic methods inclusive of case-study observations and interviews to collect qualitative data from 15 community pharmacies that were in the process of adopting or were soon to adopt EPS2. We analysed the case studies thematically and used rigorous multi-dimensional and multi-disciplinary interpretive validation techniques to cross analyse findings. Results In practice, dispensing procedures were not designed to take into account variations in human and technical integration, and assumed that repetitive and collective use of socio-technical elements were at a constant. Variables such as availability of social and technical resources, and technical know-how of staff were not taken into account in formalised procedures. Yet community pharmacies were found to adapt their dispensing in relation to the balance of social and technical elements available, and how much of the social and technical elements they were willing to integrate into dispensing. While some integrated as few technical elements as possible, some depended entirely on technical artefacts. This pattern also applied to the social elements of dispensing. Through the conceptual

  7. Anticipating implementation of colorectal cancer screening in The Netherlands: a nation wide survey on endoscopic supply and demand

    Science.gov (United States)

    2012-01-01

    Background Colorectal cancer (CRC) screening requires sufficient endoscopic resources. The present study aims to determine the Dutch endoscopic production and manpower for 2009, evaluate trends since 2004, determine additional workload which would be caused by implementation of a CRC screening program, and inventory colonoscopy rates performed in other European countries. Methods All Dutch endoscopy units (N = 101) were surveyed for manpower and the numbers of endoscopy procedures performed in 2009. Based on calculations in the report issued by the Dutch Health Council, future additional workload caused by faecal immunochemical test (FIT) screening was estimated. The number of colonoscopies performed in Europe was evaluated by a literature search and an email-inquiry. Results Compared to 2004, there was a 24% increase in total endoscopies (N = 505,226 in 2009), and a 64% increase in colonoscopies (N = 191,339 in 2009) in The Netherlands. The number of endoscopists had increased by 4.6% (N = 583 in 2009). Five years after stepwise implementation of FIT-based CRC screening, endoscopic capacity needs to be increased an additional 15%. A lack of published data on the number of endoscopies performed in Europe was found. Based on our email-inquiry, the number of colonoscopies per 100,000 inhabitants ranged from 126 to 3,031 in 15 European countries. Conclusions Over the last years, endoscopic procedures increased markedly in The Netherlands without a corresponding increase in manpower. A FIT-based CRC screening program requires an estimated additional 15% increase in endoscopic procedures. It is very likely that current colonoscopy density varies widely across European countries. PMID:22280408

  8. Anticipating implementation of colorectal cancer screening in The Netherlands: a nation wide survey on endoscopic supply and demand

    Directory of Open Access Journals (Sweden)

    van Turenhout Sietze T

    2012-01-01

    Full Text Available Abstract Background Colorectal cancer (CRC screening requires sufficient endoscopic resources. The present study aims to determine the Dutch endoscopic production and manpower for 2009, evaluate trends since 2004, determine additional workload which would be caused by implementation of a CRC screening program, and inventory colonoscopy rates performed in other European countries. Methods All Dutch endoscopy units (N = 101 were surveyed for manpower and the numbers of endoscopy procedures performed in 2009. Based on calculations in the report issued by the Dutch Health Council, future additional workload caused by faecal immunochemical test (FIT screening was estimated. The number of colonoscopies performed in Europe was evaluated by a literature search and an email-inquiry. Results Compared to 2004, there was a 24% increase in total endoscopies (N = 505,226 in 2009, and a 64% increase in colonoscopies (N = 191,339 in 2009 in The Netherlands. The number of endoscopists had increased by 4.6% (N = 583 in 2009. Five years after stepwise implementation of FIT-based CRC screening, endoscopic capacity needs to be increased an additional 15%. A lack of published data on the number of endoscopies performed in Europe was found. Based on our email-inquiry, the number of colonoscopies per 100,000 inhabitants ranged from 126 to 3,031 in 15 European countries. Conclusions Over the last years, endoscopic procedures increased markedly in The Netherlands without a corresponding increase in manpower. A FIT-based CRC screening program requires an estimated additional 15% increase in endoscopic procedures. It is very likely that current colonoscopy density varies widely across European countries.

  9. Rationale, design, and implementation protocol of the Dutch clinical practice guideline Pain in patients with cancer: a cluster randomised controlled trial with short message service (SMS) and interactive voice response (IVR)

    OpenAIRE

    te Boveldt Nienke; Engels Yvonne; Besse Kees; Vissers Kris; Vernooij-Dassen Myrra

    2011-01-01

    Abstract Background One-half of patients with cancer have pain. In nearly one out of two cancer patients with pain, this was undertreated. Inadequate pain control still remains an important problem in this group of patients. Therefore, in 2008 a national, evidence-based multidisciplinary clinical practice guideline 'pain in patients with cancer' has been developed. Yet, publishing a guideline is not enough. Implementation is needed to improve pain management. An innovative implementation stra...

  10. Implementing a one-on-one peer support program for cancer survivors using a motivational interviewing approach: results and lessons learned.

    Science.gov (United States)

    Allicock, Marlyn; Carr, Carol; Johnson, La-Shell; Smith, Rosie; Lawrence, Mary; Kaye, Leanne; Gellin, Mindy; Manning, Michelle

    2014-03-01

    Peer Connect matches cancer survivors and caregivers (guides) with those currently experiencing cancer-related issues seeking support (partners). Motivational interviewing (MI)-based communication skills are taught to provide patient-centered support. There is little guidance about MI-based applications with cancer survivors who may have multiple coping needs. This paper addresses the results and lessons learned from implementing Peer Connect. Thirteen cancer survivors and two caregivers received a 2-day MI, DVD-based training along with six supplemental sessions. Nineteen partners were matched with guides and received telephone support. Evaluation included guide skill assessment (Motivational Interviewing Treatment Integrity Code) and 6-month follow-up surveys with guides and partners. Guides demonstrated MI proficiency and perceived their training as effective. Guides provided on average of five calls to each partner. Conversation topics included cancer fears, family support needs, coping and care issues, and cancer-related decisions. Partners reported that guides provided a listening ear, were supportive, and nonjudgmental. Limited time availability of some guides was a challenge. MI can provide support for cancer survivors and caregivers without specific behavioral concerns (e.g., weight and smoking). An MI support model was both feasible and effective and can provide additional support outside of the medical system. PMID:24078346

  11. Using the diffusion of innovations theory to assess socio-technical factors in planning the implementation of an electronic health record alert across multiple primary care clinics

    Directory of Open Access Journals (Sweden)

    Ching-Pin Lin

    2016-04-01

    Conclusion: Understanding variation in organizational culture and infrastructure across primary care clinics is important in planning implementation of an intervention to reduce ADEs among patients with CKD.

  12. The second iteration of the Systems Prioritization Method: A systems prioritization and decision-aiding tool for the Waste Isolation Pilot Plant: Volume 2, Summary of technical input and model implementation

    Energy Technology Data Exchange (ETDEWEB)

    Prindle, N.H.; Mendenhall, F.T.; Trauth, K.; Boak, D.M. [Sandia National Labs., Albuquerque, NM (United States); Beyeler, W. [Science Applications International Corp., Albuquerque, NM (United States); Hora, S. [Hawaii Univ., Hilo, HI (United States); Rudeen, D. [New Mexico Engineering Research Inst., Albuquerque, NM (United States)

    1996-05-01

    The Systems Prioritization Method (SPM) is a decision-aiding tool developed by Sandia National Laboratories (SNL). SPM provides an analytical basis for supporting programmatic decisions for the Waste Isolation Pilot Plant (WIPP) to meet selected portions of the applicable US EPA long-term performance regulations. The first iteration of SPM (SPM-1), the prototype for SPM< was completed in 1994. It served as a benchmark and a test bed for developing the tools needed for the second iteration of SPM (SPM-2). SPM-2, completed in 1995, is intended for programmatic decision making. This is Volume II of the three-volume final report of the second iteration of the SPM. It describes the technical input and model implementation for SPM-2, and presents the SPM-2 technical baseline and the activities, activity outcomes, outcome probabilities, and the input parameters for SPM-2 analysis.

  13. The second iteration of the Systems Prioritization Method: A systems prioritization and decision-aiding tool for the Waste Isolation Pilot Plant: Volume 2, Summary of technical input and model implementation

    International Nuclear Information System (INIS)

    The Systems Prioritization Method (SPM) is a decision-aiding tool developed by Sandia National Laboratories (SNL). SPM provides an analytical basis for supporting programmatic decisions for the Waste Isolation Pilot Plant (WIPP) to meet selected portions of the applicable US EPA long-term performance regulations. The first iteration of SPM (SPM-1), the prototype for SPM< was completed in 1994. It served as a benchmark and a test bed for developing the tools needed for the second iteration of SPM (SPM-2). SPM-2, completed in 1995, is intended for programmatic decision making. This is Volume II of the three-volume final report of the second iteration of the SPM. It describes the technical input and model implementation for SPM-2, and presents the SPM-2 technical baseline and the activities, activity outcomes, outcome probabilities, and the input parameters for SPM-2 analysis

  14. [Montérégie Comprehensive Cancer Care Centre: integrating nurse navigators in Montérégie's oncology teams: one aspect of implementing the Cancer Control Program--Part 1].

    Science.gov (United States)

    Plante, Anne; Joannette, Sonia

    2009-01-01

    The oncology patient navigator role was developed to ensure both continuity and consultation in the delivery of care to cancer patients and their families. In Québec, this role is filled by a nurse. This first article in a series of two, aims to explain why nurses were selected as patient navigators and to describe how this new role has been integrated in the Montérégie Region. The Québec Cancer Control Program, the definition established for the oncology nurse navigator role and the implementation of an integrated care network based on the Montérégie experience will be discussed.

  15. Technical presentation

    CERN Multimedia

    FI Department

    2008-01-01

    RADIOSPARES, the leading catalogue distributor of components (electronic, electrical, automation, etc.) and industrial supplies will be at CERN on Friday 3 October 2008 (Main Building, Room B, from 9.00 a.m. to 3.00 p.m.) to introduce its new 2008/2009 catalogue. This will be the opportunity for us to present our complete range of products in more detail: 400 000 part numbers available on our web site (Radiospares France, RS International, extended range of components from other manufacturers); our new services: quotations, search for products not included in the catalogue, SBP products (Small Batch Production: packaging in quantities adapted to customers’ requirements); partnership with our focus manufacturers; demonstration of the on-line purchasing tool implemented on our web site in conjunction with CERN. RADIOSPARES will be accompanied by representatives of FLUKE and TYCO ELECTRONICS, who will make presentations, demonstrate materials and answer any technical questio...

  16. The road to clinical use of high-intensity focused ultrasound for liver cancer: technical and clinical consensus

    OpenAIRE

    Aubry, Jean-Francois; Pauly, Kim,; Moonen, Chrit; Haar, Gail Ter; Ries, Mario; Salomir, Rares; Sokka, Sham; Sekins, Kevin,; Shapira, Yerucham; Ye, Fangwei; Huff-Simonin, Heather; Eames, Matt; Hananel, Arik; Kassell, Neal; Napoli, Alessandro

    2013-01-01

    International audience Clinical use of high-intensity focused ultrasound (HIFU) under ultrasound or MR guidance as a non-invasive method for treating tumors is rapidly increasing. Tens of thousands of patients have been treated for uterine fibroid, benign prostate hyperplasia, bone metastases, or prostate cancer. Despite the methods' clinical potential, the liver is a particularly challenging organ for HIFU treatment due to the combined effect of respiratory-induced liver motion, partial b...

  17. Lung cancer epidemiology in New Mexico uranium miners: Final technical report, July 1, 1986--February 28, 1989

    International Nuclear Information System (INIS)

    A case-control study within the cohort was performed; the subjects included 65 cases and 230 age-matched controls, most with exposures below 1000 Working Level Months (WLM). The risk for lung cancer was increased for all cumulative exposures to radon decay products of 100 WLM or more. With exclusion of subjects with exposures above 1000 WLM, the estimated excess relative risk was 1.1% per WLM. The risk was greater for younger subjects and the data were consistent with a multiplicative interaction between cigarette smoking and exposure to radon progeny. The findings of the case-control study have been confirmed by conventional cohort analysis, supplemented by Poisson regression. For the entire cohort, the ratio of observed to expected lung cancer deaths was 4.1 (95% confidence limits 3.2, 5.1). A significant number of excess deaths was also found for the category ''other accidents.'' For lung cancer, the ratio of observed to expected deaths increased with cumulative exposure. Additional multivariate analyses, using the Cox proportional hazards model, are in progress. Additionally, a new panel of pathologists has been formed to review histopathological material from all available cases. 15 refs., 2 figs., 15 tabs

  18. Lung cancer epidemiology in New Mexico uranium miners. Final technical report, 1 April 1983-15 May 1986

    International Nuclear Information System (INIS)

    This investigation assessed the health effects of radon daughter exposure in New Mexico uranium miners. Cumulative exposures sustained by earlier New mexicon miners are well below those of the Colorado Plateau; more recent miners have had even lower exposures, governed by the Federal standard of 4 working level months (WLM) annually. Cohort studies of mortality in two separate groups are in progress: a retrospective cohort study of an already selected group of 3055 miners with first underground experience before 1971; and a prospective cohort study of miners first exposed from 1971 on. For both groups, records of company physical examinations will supply mining and smoking histories. Radon daughter exposures after 1967 are available from the companies. For 1967 and earlier, they will be estimated from records of measurements made by the state. During this investigation, mortality in the cohort of earlier miners through December, 1982, will be examined. The feasibility of a large prospective cohort study of more recent miners will also be determined. Analysis of the retrospective cohort data will focus on dose-response relationships for lung cancer, interaction of cigarette smoking with radon daughter exposure in lung cancer etiology, and the occurrence of lung diseases other than cancer. Conventional cohort analysis and multivariate techniques will be used

  19. 基于技术检测的装甲装备武器系统执行任务能力评估%Ability to Implement the Mandate Assessment of Armored Equipment Weapons System Based on Technical Detection

    Institute of Scientific and Technical Information of China (English)

    张辽宁; 屈洋; 张政; 邢旺

    2016-01-01

    Technology state affects the ability to implement the mandate of armored equipment weapons system greatly, yet there are few studies on its evaluation. Aimed at the problem, the paper put forward a method of evaluating the ability to implement the mandate of armored equipment based on the technical detection of equipment, and a case evaluation and analysis of a certain armored equipment weapon system is carried out. The method is operable and can provide data reference for the development of technical detection equipment and technology of armored equipment weapons system.%技术状态对装甲装备武器系统的执行任务能力有着重要影响,目前对其评估的研究还很少。针对这一问题,提出一种利用技术检测对装甲装备武器系统执行任务能力进行评估的方法,并结合某装甲装备武器系统进行了实例分析。分析结果表明:该方法具有可操作性,能够为装甲装备武器系统检测设备和技术的发展提供数据参考。

  20. SU-E-J-06: A Feasibility Study On Clinical Implementation of 4D-CBCT in Lung Cancer Treatment

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Y; Stanford, J; Duggar, W [University of Mississippi Med. Center, Jackson, MS (United States); Ruan, C [Brigham and Women' s Hospital / Harvard Medical School, Boston, MA (United States); Rajaguru, P [Univ. Mississippi Medical Center, UMC Cancer Center, Jackson, MS (United States); He, R [University of Mississippi Med. Center, Ridgeland, MS (United States); Yang, C [University of Mississippi Medical Center, Jackson, MS (United States)

    2014-06-01

    Purpose: Four-dimensional cone-beam CT (4D-CBCT) is a novel imaging technique to setup patients with pulmonary lesions in radiation therapy. This paper is to perform a feasibility study on the implementation of 4D-CBCT as image guidance for (1) SBRT and (2) Low Modulation (Low-Mod) IMRT in lung cancer treatment. Methods: Image artifacts and observers variability are evaluated by analyzing the 4D-CT QA phantom and patient 4D image data. There are two 4D-CBCT image artifacts: (1) Spatial artifact caused by the patient irregular breathing pattern will generate blurring and anatomy gap/overlap; (2) Cone beam scattering and hardening artifact will affect the image spatial and contrast resolution. The couch shift varies between 1mm to 3mm from different observers during the 4D-CBCT registration. Breath training is highly recommended to improve the respiratory regularity during CT simulation and treatment, especially for SBRT. Elekta XVI 4.5 Symmetry protocol is adopted in the patient 4DCBCT scanning and intensity-based registration. Physician adjustments on the auto-registration are involved prior to the treatment. Physician peer review on 4D-CBCT image acquisition and registration is also recommended to reduce the inter-observer variability. The average 4D-CT in reference volume coordinates is exported to MIM Vista 5.6.2 to manually fuse to the planning CT for further evaluation. Results: (1) SBRT: 4DCBCT is performed in dry-run and in each treatment fraction. Image registration and couch shift are reviewed by another physician on the 1st fraction before the treatment starts. (2) Low-Mod IMRT: 4D-CBCT is performed and peer reviewed on weekly basis. Conclusion: 4D-CBCT in SBRT dry-run can discover the ITV discrepancies caused by the low quality 4D-CT simulation. 4D-CBCT during SBRT and Low-Mod IMRT treatment provides physicians more confidence to target lung tumor and capability to evaluate inter-fractional ITV changes. More advanced 4D-CBCT scan protocol and

  1. Technical procedures for implementation of meteorology/air quality site studies, Deaf Smith County site, Texas: Environmental Field Program: Preliminary draft

    Energy Technology Data Exchange (ETDEWEB)

    1987-09-01

    This report describes The Technical Procedures that will be used to monitor air quality and meteorology. Topics include: high-volume filter handling; operation, maintenance, and calibration of the 10-M meteorological and air quality system; processing data from the 10-M meteorological tower; processing data from the 60-M meteorological tower; processing total suspended particulate filters and data from the high-volume air samplers; operation maintenance, and calibration of the 60-M meteorological and air quality system; and auditing the air quality system. 4 refs., 6 figs.

  2. Technical procedures for implementation of meteorology/air quality site studies, Deaf Smith County site, Texas: Environmental Field Program: Preliminary draft

    International Nuclear Information System (INIS)

    This report describes The Technical Procedures that will be used to monitor air quality and meteorology. Topics include: high-volume filter handling; operation, maintenance, and calibration of the 10-M meteorological and air quality system; processing data from the 10-M meteorological tower; processing data from the 60-M meteorological tower; processing total suspended particulate filters and data from the high-volume air samplers; operation maintenance, and calibration of the 60-M meteorological and air quality system; and auditing the air quality system. 4 refs., 6 figs

  3. Reference computations of public dose and cancer risk from airborne releases of plutonium. Nuclear safety technical report

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, V.L.

    1993-12-23

    This report presents results of computations of doses and the associated health risks of postulated accidental atmospheric releases from the Rocky Flats Plant (RFP) of one gram of weapons-grade plutonium in a form that is respirable. These computations are intended to be reference computations that can be used to evaluate a variety of accident scenarios by scaling the dose and health risk results presented here according to the amount of plutonium postulated to be released, instead of repeating the computations for each scenario. The MACCS2 code has been used as the basis of these computations. The basis and capabilities of MACCS2 are summarized, the parameters used in the evaluations are discussed, and results are presented for the doses and health risks to the public, both the Maximum Offsite Individual (a maximally exposed individual at or beyond the plant boundaries) and the population within 50 miles of RFP. A number of different weather scenarios are evaluated, including constant weather conditions and observed weather for 1990, 1991, and 1992. The isotopic mix of weapons-grade plutonium will change as it ages, the {sup 241}Pu decaying into {sup 241}Am. The {sup 241}Am reaches a peak concentration after about 72 years. The doses to the bone surface, liver, and whole body will increase slightly but the dose to the lungs will decrease slightly. The overall cancer risk will show almost no change over this period. This change in cancer risk is much smaller than the year-to-year variations in cancer risk due to weather. Finally, x/Q values are also presented for other applications, such as for hazardous chemical releases. These include the x/Q values for the MOI, for a collocated worker at 100 meters downwind of an accident site, and the x/Q value integrated over the population out to 50 miles.

  4. Reference computations of public dose and cancer risk from airborne releases of plutonium. Nuclear safety technical report

    International Nuclear Information System (INIS)

    This report presents results of computations of doses and the associated health risks of postulated accidental atmospheric releases from the Rocky Flats Plant (RFP) of one gram of weapons-grade plutonium in a form that is respirable. These computations are intended to be reference computations that can be used to evaluate a variety of accident scenarios by scaling the dose and health risk results presented here according to the amount of plutonium postulated to be released, instead of repeating the computations for each scenario. The MACCS2 code has been used as the basis of these computations. The basis and capabilities of MACCS2 are summarized, the parameters used in the evaluations are discussed, and results are presented for the doses and health risks to the public, both the Maximum Offsite Individual (a maximally exposed individual at or beyond the plant boundaries) and the population within 50 miles of RFP. A number of different weather scenarios are evaluated, including constant weather conditions and observed weather for 1990, 1991, and 1992. The isotopic mix of weapons-grade plutonium will change as it ages, the 241Pu decaying into 241Am. The 241Am reaches a peak concentration after about 72 years. The doses to the bone surface, liver, and whole body will increase slightly but the dose to the lungs will decrease slightly. The overall cancer risk will show almost no change over this period. This change in cancer risk is much smaller than the year-to-year variations in cancer risk due to weather. Finally, x/Q values are also presented for other applications, such as for hazardous chemical releases. These include the x/Q values for the MOI, for a collocated worker at 100 meters downwind of an accident site, and the x/Q value integrated over the population out to 50 miles

  5. Can technical characteristics predict clinical performance in PET/CT imaging? A correlation study for thyroid cancer diagnosis

    Science.gov (United States)

    Kallergi, Maria; Menychtas, Dimitrios; Georgakopoulos, Alexandros; Pianou, Nikoletta; Metaxas, Marinos; Chatziioannou, Sofia

    2013-03-01

    The purpose of this study was to determine whether image characteristics could be used to predict the outcome of ROC studies in PET/CT imaging. Patients suspected for recurrent thyroid cancer underwent a standard whole body (WB) examination and an additional high-resolution head-and-neck (HN) F18-FDG PET/CT scan. The value of the latter was determined with an ROC study, the results of which showed that the WB+HN combination was better than WB alone for thyroid cancer detection and diagnosis. Following the ROC experiment, the WB and HN images of confirmed benign or malignant thyroid disease were analyzed and first and second order textural features were determined. Features included minimum, mean, and maximum intensity, as well as contrast in regions of interest encircling the thyroid lesions. Lesion size and standard uptake values (SUV) were also determined. Bivariate analysis was applied to determine relationships between WB and HN features and between observer ROC responses and the various feature values. The two sets showed significant associations in the values of SUV, contrast, and lesion size. They were completely different when the intensities were considered; no relationship was found between the WB minimum, maximum, and mean ROI values and their HN counterparts. SUV and contrast were the strongest predictors of ROC performance on PET/CT examinations of thyroid cancer. The high resolution HN images seem to enhance these relationships but without a single dramatic effect as was projected from the ROC results. A combination of features from both WB and HN datasets may possibly be a more robust predictor of ROC performance.

  6. Utilization of Radiation Therapy in Norway After the Implementation of The National Cancer Plan—A National, Population-Based Study

    Energy Technology Data Exchange (ETDEWEB)

    Åsli, Linn M., E-mail: linn.merete.asli@kreftregisteret.no [Department of Registration, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo (Norway); Kvaløy, Stein O. [Division of Cancer, Surgery, and Transplantation, Oslo University Hospital and University of Oslo, Oslo (Norway); Jetne, Vidar [Department of Medical Physics, Oslo University Hospital, Oslo (Norway); Myklebust, Tor Å. [Department of Registration, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo (Norway); Levernes, Sverre G. [Department of Medical Physics, Oslo University Hospital, Oslo (Norway); The Norwegian Radiation Protection Authority, Østerås (Norway); Tveit, Kjell M. [Department of Oncology, Oslo University Hospital and University of Oslo, Oslo (Norway); Green, Tor O. [Department of Medical Physics, Oslo University Hospital, Oslo (Norway); Johannesen, Tom B. [Department of Registration, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo (Norway)

    2014-11-01

    Purpose: To estimate actual utilization rates of radiation therapy (RT) in Norway, describe time trends (1997-2010), and compare these estimates with corresponding optimal RT rates. Methods and Materials: Data from the population-based Cancer Registry of Norway was used to identify all patients diagnosed with cancer and/or treated by RT for cancer in 1997-2010. Radiation therapy utilization rates (RURs) were calculated as (1) the proportion of incident cancer cases who received RT at least once within 1 year of diagnosis (RUR{sub 1Y}); and (2) the proportion who received RT within 5 years of diagnosis (RUR{sub 5Y}). The number of RT treatment courses per incident cancer case (TCI) was also calculated for all cancer sites combined. The actual RURs were compared with corresponding Australian and Canadian epidemiologic- and evidence-based model estimates and criterion-based benchmark estimates of optimal RURs. The TCIs were compared with TCI estimates from the 1997 Norwegian/National Cancer Plan (NCP). Joinpoint regression was used to identify changes in trends and to estimate annual percentage change (APC) in actual RUR{sub 1Y} and actual TCI. Results: The actual RUR{sub 5Y} (all sites) increased significantly to 29% in 2005 but still differed markedly from the Australian epidemiologic- and evidence-based model estimate of 48%. With the exception of RUR{sub 5Y} for breast cancer and RUR{sub 1Y} for lung cancers, all actual RURs were markedly lower than optimal RUR estimates. The actual TCI increased significantly during the study period, reaching 42.5% in 2010, but was still lower than the 54% recommended in the NCP. The trend for RUR{sub 1Y} (all sites) and TCI changed significantly, with the annual percentage change being largest during the first part of the study period. Conclusions: Utilization rates of RT in Norway increased after the NCP was implemented and RT capacity was increased, but they still seem to be lower than optimal levels.

  7. What is being measured, and by whom? Facilitation of communication on technical measures amongst competent authorities in the implementation of the European Union Broiler Directive (2007/43/EC).

    Science.gov (United States)

    Butterworth, A; de Jong, I C; Keppler, C; Knierim, U; Stadig, L; Lambton, S

    2016-02-01

    The European Union (EU) Broiler Directive (2007/43/EC) is unique amongst current EU Directives, which address animal welfare, in that it uses outcome data collected at abattoirs and on farm to monitor on-farm broiler welfare and vary the maximum permitted stocking density on farm. In this study, we describe how, by bringing together personnel from the competent authorities in 22 member states (MSs) who have responsibility for implementing the Directive, and engaging in exchange of information and technical methods regarding the Broiler Directive, it has been possible to identify differences in approach with regard to 'what data is being collected, and by whom' across EU MSs. Online questionnaires and workshop exercises enabled us to identify priority areas for knowledge transfer and training. For example, foot pad dermatitis, hock burn, dead on arrival and total rejections (birds rejected as unfit for human consumption by the meat inspection staff at slaughter) were identified by the MSs as measures of medium-to-low priority in terms of knowledge transfer because there are assessment methods for these conditions that are already well accepted by competent authorities. On the other hand, breast lesions, cellulitis, emaciation, joint lesions, respiratory problems, scratches, wing fractures and a number of environmental measures were identified as having high priority in terms of knowledge transfer. The study identified that there is significant variability in the stage of implementation between MSs, and responses from the participating MSs indicated that sharing of guidance and technical information between MSs may be of value in the future set-up process for those MSs engaged in implementation of the Directive.

  8. Cancer

    Science.gov (United States)

    ... Blood tests (which look for chemicals such as tumor markers) Bone marrow biopsy (for lymphoma or leukemia) Chest ... the case with skin cancers , as well as cancers of the lung, breast, and colon. If the tumor has spread ...

  9. Cancer

    Science.gov (United States)

    Cancer begins in your cells, which are the building blocks of your body. Normally, your body forms ... be benign or malignant. Benign tumors aren't cancer while malignant ones are. Cells from malignant tumors ...

  10. 220kV泸定智能变电站技术方案%Implementation of Technical Scheme of 220 kV Luding Intelligent Substation

    Institute of Scientific and Technical Information of China (English)

    翁之浩; 陈文升

    2012-01-01

    The paper analyzes the intelligent technical scheme of Luding substation from the aspect of IEC 61850,networking method and intelligent device,in particularly,the application of following intelligent techniques such as IEC 61850 based unified modeling,electronic transformer,on-line monitoring device,decentralized of secondary device,etc.%从IEC 61850标准的应用、组网方式、智能化设备等方面,介绍了泸定智能变电站的技术方案,重点分析了泸定智能变电站基于IEC 61850标准统一建模、电子式互感器、设备在线监测、二次设备就地下放等应用技术。

  11. 专业技术干部综合测评管理系统的实现%The implementation of professional technical cadres assessment management system

    Institute of Scientific and Technical Information of China (English)

    孙盛智

    2014-01-01

    本设计基于B/S模式,运用ASP.NET技术,采用功能强大的Microsoft Visual Studio 2012作为开发工具、Sql Server作为数据库而开发出来的综合测评管理系统。对提高学院技术干部考核与评估的公平、公正、公开具有重大意义。%The design is based on B/S mode,using ASP.NET technology, the comprehensive assessment management system of powerful Microsoft Visual Studio 2012 as a development tool,Sql Server as database and developed. The public has great significance on improving college technical cadre evaluation and assessment of the fairness,justice.

  12. Review of technical justification of assumptions and methods used by the Environmental Protection Agency for estimating risks avoided by implementing MCLs for radionuclides

    International Nuclear Information System (INIS)

    The Environmental Protection Agency (EPA) has proposed regulations for allowable levels of radioactive material in drinking water (40 CFR Part 141, 56 FR 33050, July 18, 1991). This review examined the assumptions and methods used by EPA in calculating risks that would be avoided by implementing the proposed Maximum Contaminant Levels for uranium, radium, and radon. Proposed limits on gross alpha and beta-gamma emitters were not included in this review

  13. Review of technical justification of assumptions and methods used by the Environmental Protection Agency for estimating risks avoided by implementing MCLs for radionuclides

    Energy Technology Data Exchange (ETDEWEB)

    Morris, S.C.; Rowe, M.D.; Holtzman, S.; Meinhold, A.F.

    1992-11-01

    The Environmental Protection Agency (EPA) has proposed regulations for allowable levels of radioactive material in drinking water (40 CFR Part 141, 56 FR 33050, July 18, 1991). This review examined the assumptions and methods used by EPA in calculating risks that would be avoided by implementing the proposed Maximum Contaminant Levels for uranium, radium, and radon. Proposed limits on gross alpha and beta-gamma emitters were not included in this review.

  14. Implementation and scientific evaluation of rehabilitative sports groups for prostate cancer patients: study protocol of the ProRehab Study

    Directory of Open Access Journals (Sweden)

    Zopf Eva M

    2012-07-01

    Full Text Available Abstract Background Although treatment regimen have improved in the last few years, prostate cancer patients following a radical prostatectomy still experience severe disease- and treatment-related side effects, including urinary incontinence, erectile dysfunction and psychological issues. Despite high incidence rates and the common adverse effects there is a lack of supportive measures for male patients and specific physical exercise recommendations for prostate cancer patients during rehabilitation or in the aftercare are still missing. Methods/Design The ProRehab Project aims to establish rehabilitative sports groups particularly for prostate cancer patients and to evaluate the effects of the offered exercise program. Starting 8–12 weeks after prostatectomy or combination therapy, prostate cancer patients will exercise for 15 months within a patient preference randomized controlled trial. One exercise session will be conducted within a pre-established rehabilitative sports group, while the other will be completed independently. Patients in the control group will not participate in the intervention. The main outcomes of the study include aerobic fitness, quality of life, incontinence and erectile dysfunction. Discussion By combining science, practice, and public relations the first rehabilitative sports groups for prostate cancer patients in Germany have been set up and thus contribute to the care structure for prostate cancer patients. By offering a 15-month physical exercise intervention that is conducted in supervised group sessions, long-term lifestyle changes and therefore improvements in quality of life in prostate cancer patients can be expected. Trial registration German Clinical Trials Register DRKS00004184

  15. Teaching Technical Writing - Towards Technical Writing

    DEFF Research Database (Denmark)

    Kastberg, Peter

    2000-01-01

    In this paper I will present key aspects of the curriculum for the university degree in technical translation that I have designed for and subsequently implemented at the German Department of the Aarhus School of Business, Denmark. My starting point will be a critical discussion of the norm...... that used to govern what the quality of an LSP text should be as opposed to the standpoint, which I advocate. By way of summing up, I will show how a university curriculum is designed so that - upon graduation - the technical translator could also be methodological quite well suited to take on the challenge...

  16. Final Scientific/Technical Report for DOE/EERE Comprehensive Community Renewable Energy Implementation Plan in Forest County and Milwaukee County

    Energy Technology Data Exchange (ETDEWEB)

    Karman, Nathan [Forest County Potawatomi Community, Crandon, WI (United States)

    2014-06-27

    Forest County Potawatomi Community (the “Community”) sought and obtained Community Renewable Energy Deployment funding from the Department of Energy to evaluate and implement a diverse number of renewable energy technologies throughout its lands held in trust or owned in fee simple in Forest County and Milwaukee County (the “Project”). The technologies and sites evolved during the Project, ultimately leading to the investigation of biomass and solar projects on the Community’s reservation in Forest County, as well as the investigation and eventual deployment of a solar project and an anaerobic digestion and biogas project on Community lands in Milwaukee.

  17. Proceedings of the IEA-technical workshop for an international fusion materials irradiation facility. IEA-implementing agreement for a programme of research and development on fusion materials

    International Nuclear Information System (INIS)

    The workshop was initiated to deal with the following objectives: (1) Critical review of the requirements for IFMIF from the user's point of view; (2) Definition of a baseline concept for the CDA-study; (3) Formation of working groups for main fields of activities; (4) Identification of tasks and critical issues for main components; (5) Development of a working break-down structure, distribution of work and milestones for CDA-activities; (6) Documentation of main results. According to the enclosed agenda the mission for a Conceptual Design Study, the requirements for an intense neutron source from the user's point of view and the baseline concept for an accelerator-driven D-Li neutron source were discussed in several plenary sessions. In three subgroups (SG 1 Accelerators, SG2 Lithium Target and SG3 Users and Test Cell) technical concepts for the different components and facilities were discussed in detail, critical issues and tasks for the concept study were identified. Finally, the sharing of tasks to the different national parties, questions of organisation of the work, flow of information and definition of milestones was agreed upon. The detailled summary reports of the subgroups and the contributions of the plenary sessions are presented in the proceedings. (orig./HP)

  18. Implementing waste minimization at an active plutonium processing facility: Successes and progress at technical area (TA) -55 of the Los Alamos National Laboratory

    International Nuclear Information System (INIS)

    The Los Alamos National Laboratory has ongoing national security missions that necessitate increased plutonium processing. The bulk of this activity occurs at Technical Area -55 (TA-55), the nations only operable plutonium facility. TA-55 has developed and demonstrated a number of technologies that significantly minimize waste generation in plutonium processing (supercritical CO2, Mg(OH)2 precipitation, supercritical H2O oxidation, WAND), disposition of excess fissile materials (hydride-dehydride, electrolytic decontamination), disposition of historical waste inventories (salt distillation), and Decontamination ampersand Decommissioning (D ampersand D) of closed nuclear facilities (electrolytic decontamination). Furthermore, TA-55 is in the process of developing additional waste minimization technologies (molten salt oxidation, nitric acid recycle, americium extraction) that will significantly reduce ongoing waste generation rates and allow volume reduction of existing waste streams. Cost savings from reduction in waste volumes to be managed and disposed far exceed development and deployment costs in every case. Waste minimization is also important because it reduces occupational exposure to ionizing radiation, risks of transportation accidents, and transfer of burdens from current nuclear operations to future generations

  19. (18)F-FDG PET/CT quantification in head and neck squamous cell cancer: principles, technical issues and clinical applications.

    Science.gov (United States)

    Manca, Gianpiero; Vanzi, Eleonora; Rubello, Domenico; Giammarile, Francesco; Grassetto, Gaia; Wong, Ka Kit; Perkins, Alan C; Colletti, Patrick M; Volterrani, Duccio

    2016-07-01

    (18)F-FDG PET/CT plays a crucial role in the diagnosis and management of patients with head and neck squamous cell cancer (HNSCC). The major clinical applications of this method include diagnosing an unknown primary tumour, identifying regional lymph node involvement and distant metastases, and providing prognostic information. (18)F-FDG PET/CT is also used for precise delineation of the tumour volume for radiation therapy planning and dose painting, and for treatment response monitoring, by detecting residual or recurrent disease. Most of these applications would benefit from a quantitative approach to the disease, but the quantitative capability of (18)F-FDG PET/CT is still underused in HNSCC. Innovations in PET/CT technology promise to overcome the issues that until now have hindered the employment of dynamic procedures in clinical practice and have limited "quantification" to the evaluation of standardized uptake values (SUV), de facto a semiquantitative parameter, the limits of which are well known to the nuclear medicine community. In this paper the principles of quantitative imaging and the related technical issues are reviewed so that professionals involved in HNSCC management can reflect on the advantages of "true" quantification. A discussion is then presented on how semiquantitative information is currently used in clinical (18)F-FDG PET/CT applications in HNSCC, by discussing the improvements that could be obtained with more advanced and "personalized" quantification techniques.

  20. (18)F-FDG PET/CT quantification in head and neck squamous cell cancer: principles, technical issues and clinical applications.

    Science.gov (United States)

    Manca, Gianpiero; Vanzi, Eleonora; Rubello, Domenico; Giammarile, Francesco; Grassetto, Gaia; Wong, Ka Kit; Perkins, Alan C; Colletti, Patrick M; Volterrani, Duccio

    2016-07-01

    (18)F-FDG PET/CT plays a crucial role in the diagnosis and management of patients with head and neck squamous cell cancer (HNSCC). The major clinical applications of this method include diagnosing an unknown primary tumour, identifying regional lymph node involvement and distant metastases, and providing prognostic information. (18)F-FDG PET/CT is also used for precise delineation of the tumour volume for radiation therapy planning and dose painting, and for treatment response monitoring, by detecting residual or recurrent disease. Most of these applications would benefit from a quantitative approach to the disease, but the quantitative capability of (18)F-FDG PET/CT is still underused in HNSCC. Innovations in PET/CT technology promise to overcome the issues that until now have hindered the employment of dynamic procedures in clinical practice and have limited "quantification" to the evaluation of standardized uptake values (SUV), de facto a semiquantitative parameter, the limits of which are well known to the nuclear medicine community. In this paper the principles of quantitative imaging and the related technical issues are reviewed so that professionals involved in HNSCC management can reflect on the advantages of "true" quantification. A discussion is then presented on how semiquantitative information is currently used in clinical (18)F-FDG PET/CT applications in HNSCC, by discussing the improvements that could be obtained with more advanced and "personalized" quantification techniques. PMID:26780912

  1. 18F-FDG PET/CT quantification in head and neck squamous cell cancer: principles, technical issues and clinical applications

    International Nuclear Information System (INIS)

    18F-FDG PET/CT plays a crucial role in the diagnosis and management of patients with head and neck squamous cell cancer (HNSCC). The major clinical applications of this method include diagnosing an unknown primary tumour, identifying regional lymph node involvement and distant metastases, and providing prognostic information. 18F-FDG PET/CT is also used for precise delineation of the tumour volume for radiation therapy planning and dose painting, and for treatment response monitoring, by detecting residual or recurrent disease. Most of these applications would benefit from a quantitative approach to the disease, but the quantitative capability of 18F-FDG PET/CT is still underused in HNSCC. Innovations in PET/CT technology promise to overcome the issues that until now have hindered the employment of dynamic procedures in clinical practice and have limited ''quantification'' to the evaluation of standardized uptake values (SUV), de facto a semiquantitative parameter, the limits of which are well known to the nuclear medicine community. In this paper the principles of quantitative imaging and the related technical issues are reviewed so that professionals involved in HNSCC management can reflect on the advantages of ''true'' quantification. A discussion is then presented on how semiquantitative information is currently used in clinical 18F-FDG PET/CT applications in HNSCC, by discussing the improvements that could be obtained with more advanced and ''personalized'' quantification techniques. (orig.)

  2. Implementation and Practice of A Technical Document System for Medical Equipment%医疗设备动态技术档案管理系统的建设与实践

    Institute of Scientific and Technical Information of China (English)

    江川

    2011-01-01

    本文介绍了医疗设备动态技术档案管理系统的建设与实践.运用计算机网络系统的优势,对医疗设备进行动态档案的建立,加强对医疗设备的动态管理,增加设备的产出率,为科学利用设备提供决策依据.%This paper introduces the implementation and practice of a technical document system for medical equipment. The construction of this system taking the advantage of network system,strengthened the dynamic management of medical equipment, increased the output of equipment, and took a strategic decision on scientific use of medical equipment.

  3. Technical Scheme for Implementation of Communication System Integration on Harbin-Dalian Passenger Dedicated Line%哈大铁路客运专线通信系统集成实施技术方案

    Institute of Scientific and Technical Information of China (English)

    代永维; 石波

    2012-01-01

    根据工程实际情况和铁道部相关技术标准要求,研究哈大客运专线通信系统集成实施技术方案,包括传输、电话交换及接入、数据网、专用移动通信等15个子系统的业务需求、组网方案、网络结构、节点设置以及设备主要配置原则等.%According to actual engineering conditions and relevant technical specifications of MOR, studies are conducted on the technical scheme for implementation of communication system integration on Harbin-Dalian passenger dedicated line, including business demands, network composition scheme, network structure, nods arrangement and key device configuration strategy related to 15 subsystems such as transmission, phone exchange and place-in, data network, special mobile communication and etc.

  4. Technical Shibboleths.

    Science.gov (United States)

    Harris, John S.

    1998-01-01

    Focuses on technical sub-languages to reveal sociological functions of language that transcend mere transfer of substantive information. Finds one sociological feature, the shibboleth, acting widely throughout technical fields. (PA)

  5. [Cancer].

    Science.gov (United States)

    de la Peña-López, Roberto; Remolina-Bonilla, Yuly Andrea

    2016-09-01

    Cancer is a group of diseases which represents a significant public health problem in Mexico and worldwide. In Mexico neoplasms are the second leading cause of death. An increased morbidity and mortality are expected in the next decades. Several preventable risk factors for cancer development have been identified, the most relevant including tobacco use, which accounts for 30% of the cancer cases; and obesity, associated to another 30%. These factors, in turn, are related to sedentarism, alcohol abuse and imbalanced diets. Some agents are well knokn to cause cancer such as ionizing radiation, viruses such as the papilloma virus (HPV) and hepatitis virus (B and C), and more recently environmental pollution exposure and red meat consumption have been pointed out as carcinogens by the International Agency for Research in Cancer (IARC). The scientific evidence currently available is insufficient to consider milk either as a risk factor or protective factor against different types of cancer. PMID:27603890

  6. Contribution of SLN investigation with {sup 99m}Tc-nanocolloid in clinical staging of thyroid cancer: technical feasibility

    Energy Technology Data Exchange (ETDEWEB)

    Pelizzo, Maria Rosa [Istituto Oncologico Veneto (IOV), Nuclear Medicine, PET Unit, S. Maria della Misericordia Hospital, Rovigo (Italy); Rubello, Domenico; Merante Boschin, Isabella; Piotto, Andrea; Paggetta, Costantino; Toniato, Antonio [University of Padova, Department of Surgical Science, Padova (Italy); De Salvo, Gian Luca [Istituto Oncologico Veneto (IOV), Epidemiology Unit, Padova (Italy); Giuliano, Armando [University of Pisa, Regional Center of Nuclear Medicine, Pisa (Italy); Mariani, Giuliano [John Wayne Cancer Institute, Department of Surgical Oncology, Santa Monica, CA (United States); Casara, Dario [Istituto Oncologico Veneto (IOV), Via Giustiniani, 2, Nuclear Medicine Service, Padova (Italy)

    2007-06-15

    high in our series: in 48% of patients at least one metastatic lymph node was found. From a technical point of view the intra-operative SLN procedure in PTC patients was easy to perform, without major intra-operative complications. Our promising preliminary experience needs to be confirmed in larger series of patients series with longer follow-up. (orig.)

  7. Improved technical specifications

    Energy Technology Data Exchange (ETDEWEB)

    Hoffman, D.R.

    1994-12-31

    Improved technical specifications for nuclear power plants are outlined. The objectives of this work are to improve safety, provide a clearer understanding of safety significance, and ease NRC and industry administrative burdens. Line item improvements, bases, and implementation of the specifications are discussed.

  8. Adaptation of an Evidence-Based Colorectal Cancer Screening Program Using the Consolidated Framework for Implementation Research

    OpenAIRE

    Cole, Allison M; Esplin, Andrea; Baldwin, Laura-Mae

    2015-01-01

    Introduction Federally Qualified Health Centers (FQHCs) provide primary care to low-income and uninsured patients in the United States. FQHCs are required to report annual measurements and provide evidence of improvement for quality measures; effective methods to improve quality in FQHCs are needed. Systems of Support (SOS) is a proactive, mail-based, colorectal cancer screening program that was developed and tested in an integrated health care system. The objective of this study was to adapt...

  9. Conceptual and practical challenges for implementing the communities of practice model on a national scale - a Canadian cancer control initiative

    OpenAIRE

    Browman George P; Bentley Colene; Poole Barbara

    2010-01-01

    Abstract Background Cancer program delivery, like the rest of health care in Canada, faces two ongoing challenges: to coordinate a pan-Canadian approach across complex provincial jurisdictions, and to facilitate the rapid translation of knowledge into clinical practice. Communities of practice, or CoPs, which have been described by Etienne Wenger as a collaborative learning platform, represent a promising solution to these challenges because they rely on bottom-up rather than top-down social ...

  10. Evaluation of physical parameters and implementation of quality control in mammography diagnosed for a pilot of breast cancer screening in the Caja Costarricense de Seguro Social (CCSS)

    International Nuclear Information System (INIS)

    The purpose of mammography has been to provide the contrast between the lesion and adjacent healthy tissue of the breast. The quality control which should be performed in mammography services is essential to obtain the necessary contrast in mammography and thus achieve a prompt detection of breast lesions. The quality control program has helped to obtain exact diagnosis in mammography and has contributed to reduce mortality from breast cancer in Costa Rica. The Caja Costarricense de Seguro Social (CCSS) has sought to improve the quality of mammograms performed in the different health centers by implementing quality control programs in the services. The evaluation of the physical parameters has had as aim to perform an assessment of the equipment used in mammography facilities. The image quality, dosimetry, optical density, performance, accuracy and repeatability of voltage applied to the tube, filtration and Half-value layer in system of screen film mammography have been evaluated. The usefulness of quality control programs and needs of the services to implement a pilot plan for breast screening, can be seen when comparing the obtained results. The protocol of Mammography Quality Control, TECDOC 1517 from the International Atomic Energy Agency (IAEA), is implemented with this project and the associated software in four of the six hospitals evaluated in this study. (author)

  11. Technical Note: Implementation of biological washout processes within GATE/GEANT4—A Monte Carlo study in the case of carbon therapy treatments

    Energy Technology Data Exchange (ETDEWEB)

    Martínez-Rovira, I., E-mail: immamartinez@gmail.com; Jouvie, C.; Jan, S. [Service Hospitalier Frédéric Joliot, Commissariat à l’énergie atomique et aux énergies alternatives (CEA/DSV/I2BM/SHFJ), 4 place du général Leclerc, 91401 Orsay Cedex (France)

    2015-04-15

    Purpose: The imaging of positron emitting isotopes produced during patient irradiation is the only in vivo method used for hadrontherapy dose monitoring in clinics nowadays. However, the accuracy of this method is limited by the loss of signal due to the metabolic decay processes (biological washout). In this work, a generic modeling of washout was incorporated into the GATE simulation platform. Additionally, the influence of the washout on the β{sup +} activity distributions in terms of absolute quantification and spatial distribution was studied. Methods: First, the irradiation of a human head phantom with a {sup 12}C beam, so that a homogeneous dose distribution was achieved in the tumor, was simulated. The generated {sup 11}C and {sup 15}O distribution maps were used as β{sup +} sources in a second simulation, where the PET scanner was modeled following a detailed Monte Carlo approach. The activity distributions obtained in the presence and absence of washout processes for several clinical situations were compared. Results: Results show that activity values are highly reduced (by a factor of 2) in the presence of washout. These processes have a significant influence on the shape of the PET distributions. Differences in the distal activity falloff position of 4 mm are observed for a tumor dose deposition of 1 Gy (T{sub ini} = 0 min). However, in the case of high doses (3 Gy), the washout processes do not have a large effect on the position of the distal activity falloff (differences lower than 1 mm). The important role of the tumor washout parameters on the activity quantification was also evaluated. Conclusions: With this implementation, GATE/GEANT 4 is the only open-source code able to simulate the full chain from the hadrontherapy irradiation to the PET dose monitoring including biological effects. Results show the strong impact of the washout processes, indicating that the development of better models and measurement of biological washout data are

  12. {sup 18}F-FDG PET/CT quantification in head and neck squamous cell cancer: principles, technical issues and clinical applications

    Energy Technology Data Exchange (ETDEWEB)

    Manca, Gianpiero; Volterrani, Duccio [University Hospital of Pisa, Regional Center of Nuclear Medicine, Pisa (Italy); Vanzi, Eleonora [University Hospital of Siena, Service of Medical Physics, Siena (Italy); Rubello, Domenico; Grassetto, Gaia [Santa Maria della Misericordia Rovigo Hospital, Department of Nuclear Medicine, Rovigo (Italy); Giammarile, Francesco [Faculte Charles Merieux, Medecine Nucleaire, Centre Hospitalier and Biophysique, Lyon (France); Wong, Ka Kit [University of Michigan Hospital, Nuclear Medicine/Radiology Department, Ann Arbor, MI (United States); Nuclear Medicine Service, Department of Veterans Affairs Health System, Ann Arbor, MI (United States); Perkins, Alan C. [University of Nottingham, Department of Radiological Sciences, School of Medicine, Nottingham (United Kingdom); Colletti, Patrick M. [Southern University of California, Department of Radiology, Los Angeles, CA (United States)

    2016-07-15

    {sup 18}F-FDG PET/CT plays a crucial role in the diagnosis and management of patients with head and neck squamous cell cancer (HNSCC). The major clinical applications of this method include diagnosing an unknown primary tumour, identifying regional lymph node involvement and distant metastases, and providing prognostic information. {sup 18}F-FDG PET/CT is also used for precise delineation of the tumour volume for radiation therapy planning and dose painting, and for treatment response monitoring, by detecting residual or recurrent disease. Most of these applications would benefit from a quantitative approach to the disease, but the quantitative capability of {sup 18}F-FDG PET/CT is still underused in HNSCC. Innovations in PET/CT technology promise to overcome the issues that until now have hindered the employment of dynamic procedures in clinical practice and have limited ''quantification'' to the evaluation of standardized uptake values (SUV), de facto a semiquantitative parameter, the limits of which are well known to the nuclear medicine community. In this paper the principles of quantitative imaging and the related technical issues are reviewed so that professionals involved in HNSCC management can reflect on the advantages of ''true'' quantification. A discussion is then presented on how semiquantitative information is currently used in clinical {sup 18}F-FDG PET/CT applications in HNSCC, by discussing the improvements that could be obtained with more advanced and ''personalized'' quantification techniques. (orig.)

  13. Sponsoring Organization | Division of Cancer Prevention

    Science.gov (United States)

    The National Cancer Institute (NCI) project officers are responsible for the design and oversight of all aspects of the PLCO trial. These NCI components work directly with the Coordinating Center which provides support for development and implementation of the study protocol; and with the Principal Investigators from each of the Screening Centers to ensure that the technical aspects of the trial are carried out under rigorous scientific standards. |

  14. Design and implementation of a decision support system for breast cancer treatment based on clinical practice guidelines

    International Nuclear Information System (INIS)

    Evidence based medicine is the clinical practice that uses medical data and proof in order to make efficient clinical decisions. Information technology (IT) can play a crucial role in exploiting the huge size of raw medical data involved. In an attempt to improve clinical efficacy, health care society nowadays also utilizes a new assistant, clinical guidelines. Our research concerns the medical domain of the breast cancer disease. Our research's focus is twofold; our primary goal is to ensure consistency in clinical practice by importing clinical guidelines in an IT driven decision support system (DSS). Furthermore, we seek to improve visualization of disease specific, clinical data, providing for it's faster and more efficient use. (orig.)

  15. Implementation of next-generation sequencing for molecular diagnosis of hereditary breast and ovarian cancer highlights its genetic heterogeneity.

    Science.gov (United States)

    Pinto, Pedro; Paulo, Paula; Santos, Catarina; Rocha, Patrícia; Pinto, Carla; Veiga, Isabel; Pinheiro, Manuela; Peixoto, Ana; Teixeira, Manuel R

    2016-09-01

    Molecular diagnosis of hereditary breast and ovarian cancer (HBOC) by standard methodologies has been limited to the BRCA1 and BRCA2 genes. With the recent development of new sequencing methodologies, the speed and efficiency of DNA testing have dramatically improved. The aim of this work was to validate the use of next-generation sequencing (NGS) for the detection of BRCA1/BRCA2 point mutations in a diagnostic setting and to study the role of other genes associated with HBOC in Portuguese families. A cohort of 94 high-risk families was included in the study, and they were initially screened for the two common founder mutations with variant-specific methods. Fourteen index patients were shown to carry the Portuguese founder mutation BRCA2 c.156_157insAlu, and the remaining 80 were analyzed in parallel by Sanger sequencing for the BRCA1/BRCA2 genes and by NGS for a panel of 17 genes that have been described as involved in predisposition to breast and/or ovarian cancer. A total of 506 variants in the BRCA1/BRCA2 genes were detected by both methodologies, with a 100 % concordance between them. This strategy allowed the detection of a total of 39 deleterious mutations in the 94 index patients, namely 10 in BRCA1 (25.6 %), 21 in BRCA2 (53.8 %), four in PALB2 (10.3 %), two in ATM (5.1 %), one in CHEK2 (2.6 %), and one in TP53 (2.6 %), with 20.5 % of the deleterious mutations being found in genes other than BRCA1/BRCA2. These results demonstrate the efficiency of NGS for the detection of BRCA1/BRCA2 point mutations and highlight the genetic heterogeneity of HBOC. PMID:27553368

  16. 基于虚拟机实时迁移的绿色云计算及其技术实现%GREEN CLOUD COMPUTING BASED ON LIVE MIGRATION OF VIRTUAL MACHINE AND ITS TECHNICAL IMPLEMENTATION

    Institute of Scientific and Technical Information of China (English)

    魏坤; 许晖; 杨旸

    2013-01-01

    A great number of servers will consume huge amount of energy in cloud computing,therefore how to make cloud computing more "green" is increasingly concerned by the people.Using green energy is a promising way to solve this problem.However,due to the instability of green energy supply,the wide application of green energy in cloud computing meets its obstruction.In this paper,we use the live migration technology of virtual machine to have implemented the all-weather working of cloud computing network powered by green energy.The technical implementation illustration of the "Greenstar Network" cloud computing node built with this scheme is also introduced.%在云计算中,大量的服务器要消耗巨大的电力,如何让云计算更加绿色是人们日益关注的问题.使用绿色能源是解决这一问题的有效手段,但绿色能源供电具有一定的波动性,这给绿色能源在云计算的广泛应用带来了一定的限制.利用虚拟机的实时迁移技术实现绿色能源供能的云计算网络的全天候工作,并给出利用该方案搭建绿色之星网络云计算节点的技术实现说明.

  17. Clinical Implementation of an Online Adaptive Plan-of-the-Day Protocol for Nonrigid Motion Management in Locally Advanced Cervical Cancer IMRT

    Energy Technology Data Exchange (ETDEWEB)

    Heijkoop, Sabrina T., E-mail: s.heijkoop@erasmusmc.nl; Langerak, Thomas R.; Quint, Sandra; Bondar, Luiza; Mens, Jan Willem M.; Heijmen, Ben J.M.; Hoogeman, Mischa S.

    2014-11-01

    Purpose: To evaluate the clinical implementation of an online adaptive plan-of-the-day protocol for nonrigid target motion management in locally advanced cervical cancer intensity modulated radiation therapy (IMRT). Methods and Materials: Each of the 64 patients had four markers implanted in the vaginal fornix to verify the position of the cervix during treatment. Full and empty bladder computed tomography (CT) scans were acquired prior to treatment to build a bladder volume-dependent cervix-uterus motion model for establishment of the plan library. In the first phase of clinical implementation, the library consisted of one IMRT plan based on a single model-predicted internal target volume (mpITV), covering the target for the whole pretreatment observed bladder volume range, and a 3D conformal radiation therapy (3DCRT) motion-robust backup plan based on the same mpITV. The planning target volume (PTV) combined the ITV and nodal clinical target volume (CTV), expanded with a 1-cm margin. In the second phase, for patients showing >2.5-cm bladder-induced cervix-uterus motion during planning, two IMRT plans were constructed, based on mpITVs for empty-to-half-full and half-full-to-full bladder. In both phases, a daily cone beam CT (CBCT) scan was acquired to first position the patient based on bony anatomy and nodal targets and then select the appropriate plan. Daily post-treatment CBCT was used to verify plan selection. Results: Twenty-four and 40 patients were included in the first and second phase, respectively. In the second phase, 11 patients had two IMRT plans. Overall, an IMRT plan was used in 82.4% of fractions. The main reasons for selecting the motion-robust backup plan were uterus outside the PTV (27.5%) and markers outside their margin (21.3%). In patients with two IMRT plans, the half-full-to-full bladder plan was selected on average in 45% of the first 12 fractions, which was reduced to 35% in the last treatment fractions. Conclusions: The implemented

  18. Technical Architecture and Implementation of Intelligent System for Agriculture Domain%面向农业领域的智能系统技术体系架构及其实现

    Institute of Scientific and Technical Information of China (English)

    熊范纶

    2012-01-01

    A series of studies on the technical architecture of intelligent system for agriculture domain is elaborated in this paper, including key technologies such as the expert system, knowledge representation, inference mechanism, knowledge acquisition, development platform, intelligent computing, machine learning, data mining, ontology, artificial life and their implementations to decision support, control, forecasting, retrieval , simulation in fertilization of crops, diagnosis and treatment of plant diseases and insect pests, cultivation, horticulture, livestock and aquaculture etc. It shows that application of intelligent and information technology into agricultural domain is of broad prospect.%阐述作者及团队对农业智能系统的技术体系架构取得的研究成果,包括运用专家系统、知识表示、推理机制、知识获取、开发平台,智能计算、机器学习、数据挖掘、本体论、人工生命等关键技术,探索在作物施肥、病虫害诊治、栽培管理,园艺以及畜禽水产养殖等方面,应用于决策支持、控制、预测、检索、仿真等,反映了智能信息技术面向农业领域,具有广阔的应用前景.

  19. Optimization and Implementation of Technical Proposal for Electric Control System of Mining Hoist%煤矿提升机电控系统技术方案优化与实施

    Institute of Scientific and Technical Information of China (English)

    苗少刚

    2015-01-01

    提升机作为煤矿生产中的关键设备,其电控系统技术的优化不仅关系到提升机的工作性能,也对煤矿运输的工作效率产生重要影响。本文首先介绍了煤矿提升机电控系统的基本功能,并对煤矿提升机电控系统技术方案的优化策略进行了论述分析,以期促进提升机电控系统在我国煤矿生产中的实施与应用。%Hoist is a kind of main transport equipment in mine production ,whose electric control system concerns the working performance of hoist and the working efficiency of transport as well .Based on the introduction to basic functions of electric control system in mining hoist ,the author expounds its technical optimization propos‐als ,which will promote the implementation and application of electric control system in mine production .

  20. The Peru Cervical Cancer Screening Study (PERCAPS): the design and implementation of a mother/daughter screen, treat, and vaccinate program in the Peruvian jungle.

    Science.gov (United States)

    Abuelo, Carolina E; Levinson, Kimberly L; Salmeron, Jorge; Sologuren, Carlos Vallejos; Fernandez, Maria Jose Vallejos; Belinson, Jerome L

    2014-06-01

    Peru struggles to prevent cervical cancer (CC). In the jungle, prevention programs suffer from significant barriers although technology exists to detect CC precursors. This study used community based participatory research (CBPR) methods to overcome barriers. The objective was to evaluate the utility of CBPR techniques in a mother-child screen/treat and vaccinate program for CC prevention in the Peruvian jungle. The CC prevention program used self-sampling for human papillomavirus (HPV) for screening, cryotherapy for treatment and the HPV vaccine Gardasil for vaccination. Community health leaders (HL) from around Iquitos participated in a two half day educational course. The HLs then decided how to implement interventions in their villages or urban sectors. The success of the program was measured by: (1) ability of the HLs to determine an implementation plan, (2) proper use of research forms, (3) participation and retention rates, and (4) participants' satisfaction. HLs successfully registered 320 women at soup kitchens, schools, and health posts. Screening, treatment, and vaccination were successfully carried out using forms for registration, consent, and results with minimum error. In the screen/treat intervention 100% of participants gave an HPV sample and 99.7% reported high satisfaction; 81% of HPV + women were treated, and 57% returned for 6-month followup. Vaccine intervention: 98% of girls received the 1st vaccine, 88% of those received the 2nd, and 65% the 3rd. CBPR techniques successfully helped implement a screen/treat and vaccinate CC prevention program around Iquitos, Peru. These techniques may be appropriate for large-scale preventive health-care interventions.

  1. Conceptual and practical challenges for implementing the communities of practice model on a national scale - a Canadian cancer control initiative

    Directory of Open Access Journals (Sweden)

    Browman George P

    2010-01-01

    Full Text Available Abstract Background Cancer program delivery, like the rest of health care in Canada, faces two ongoing challenges: to coordinate a pan-Canadian approach across complex provincial jurisdictions, and to facilitate the rapid translation of knowledge into clinical practice. Communities of practice, or CoPs, which have been described by Etienne Wenger as a collaborative learning platform, represent a promising solution to these challenges because they rely on bottom-up rather than top-down social structures for integrating knowledge and practice across regions and agencies. The communities of practice model has been realized in the corporate (e.g., Royal Dutch Shell, Xerox, IBM, etc and development (e.g., World Bank sectors, but its application to health care is relatively new. The Canadian Partnership Against Cancer (CPAC is exploring the potential of Wenger's concept in the Canadian health care context. This paper provides an in-depth analysis of Wenger's concept with a focus on its applicability to the health care sector. Discussion Empirical studies and social science theory are used to examine the utility of Wenger's concept. Its value lies in emphasizing learning from peers and through practice in settings where innovation is valued. Yet the communities of practice concept lacks conceptual clarity because Wenger defines it so broadly and sidelines issues of decision making within CoPs. We consider the implications of his broad definition to establishing an informed nomenclature around this specific type of collaborative group. The CoP Project under CPAC and communities of practice in Canadian health care are discussed. Summary The use of communities of practice in Canadian health care has been shown in some instances to facilitate quality improvements, encourage buy in among participants, and generate high levels of satisfaction with clinical leadership and knowledge translation among participating physicians. Despite these individual success

  2. Successful implementation of a telemedicine-based counseling program for high-risk patients with breast cancer.

    Science.gov (United States)

    Pruthi, Sandhya; Stange, Kevin J; Malagrino, Gerald D; Chawla, Kashmira S; LaRusso, Nicholas F; Kaur, Judith S

    2013-01-01

    An interactive audio and video telemedicine feasibility program was established to provide counseling on breast cancer risk-reducing strategies for underserved, high-risk Alaskan native women through a collaboration among the Alaska Native Medical Center, the Mayo Clinic Breast Clinic, Mayo's Center for Innovation, and the Alaska Federal Health Care Access Network. The telemedicine model included a navigator to facilitate patient encounters (referrals, electronic records, and scheduling) and a subscription billing contract. Between January 1 and December 31, 2011, 60 consultations were provided to the Alaska Native Medical Center. A survey of a sample of 15 women demonstrated overall patient satisfaction of 98% pertaining to the experience, technology, and medical consultation. The referring physician satisfaction, from 11 visit surveys and 8 referring physicians, revealed 99% satisfaction with the service. In this telemedicine pilot study, we demonstrated the feasibility of a telemedicine program to provide integrated specialty care that resulted in a positive effect on patient satisfaction. This program has a sustainable business model, thus creating a new modality for health care delivery. PMID:23274020

  3. 面向社会技术系统的可变承诺自适应实现框架%IMPLEMENTATION FRAMEWORK OF EVOLVING COMMITMENTS SELF-ADAPTATION FOR SOCIAL-TECHNICAL SYSTEM

    Institute of Scientific and Technical Information of China (English)

    谢奕; 陈碧欢; 彭鑫; 赵文耘

    2015-01-01

    社会技术系统通常由人类、硬件和软件主体组成,通过它们之间的协同工作满足相关涉众的需求。由于社会技术系统的开放性、动态性和持续变化性,这类系统中的主体需要动态地调整自己的行为,以适应动态变化的环境。一些研究工作已经提出了支持动态重配置和可变承诺的面向社会技术系统的自适应方法。然而,目前还缺少基于这种方法的实现框架。针对这一问题,提出一个基于主体的自适应实现框架,为社会技术系统提供基于可变承诺的自适应能力。该框架是基于 JADE(Java Agent Development Framework)平台来实现的,并且提供了面向特定系统的监控器接口和执行器接口来实现个性化配置。最后,通过一个案例分析验证了该实现框架的有效性。%Socio-technical systems (STSs)are usually composed of humankind,hardware and software agents,through the collaborated operations between them the requirements of correlated peoples involved are satisfied.Since most STSs work in open,dynamic and constant evolving environments,the agents in STSs need to dynamically adjust their own behaviours to adapt to the dynamically evolving environment. A couple of research works have presented the STSs-oriented self-adaptation approaches that support the dynamic reconfiguration and evolving commitments.However there is still lack of the implementation framework based on such methods.To address this issue,this paper proposes an agent-based self-adaptation implementation framework that provides the evolving commitments-based self-adaptation capability for STSs. This framework works on JADE platform and provides monitor and actuator interfaces for specific system to realise the individualised configuration.At last,through a case analysis we verify the effectiveness of the framework implementation.

  4. Technical Network

    CERN Multimedia

    2007-01-01

    In order to optimize the management of the Technical Network (TN), to ease the understanding and purpose of devices connected to the TN, and to improve security incident handling, the Technical Network Administrators and the CNIC WG have asked IT/CS to verify the "description" and "tag" fields of devices connected to the TN. Therefore, persons responsible for systems connected to the TN will receive email notifications from IT/CS asking them to add the corresponding information in the network database. Thank you very much for your cooperation. The Technical Network Administrators & the CNIC WG

  5. Technical Network

    CERN Multimedia

    2007-01-01

    In order to optimise the management of the Technical Network (TN), to facilitate understanding of the purpose of devices connected to the TN and to improve security incident handling, the Technical Network Administrators and the CNIC WG have asked IT/CS to verify the "description" and "tag" fields of devices connected to the TN. Therefore, persons responsible for systems connected to the TN will receive e-mails from IT/CS asking them to add the corresponding information in the network database at "network-cern-ch". Thank you very much for your cooperation. The Technical Network Administrators & the CNIC WG

  6. Modality-dependent dose requirements in the Austrian breast cancer early detection program. First results from technical quality assurance; Geraeteabhaengiger Dosisbedarf im Oesterreichischen Brustkrebsfrueherkennungsprogramm. Erste Ergebnisse aus der technischen Qualitaetssicherung

    Energy Technology Data Exchange (ETDEWEB)

    Osanna-Elliott, A.; Semturs, F.; Menhart, S.; Schloegl, C.; Wildner, S.; Zwettler, G. [AGES, Wien (Austria). Referenzzentrum fuer technische Qualitaetssicherung im Brustkrebsfrueherkennungsprogramm

    2015-07-01

    The Austrian Breast Cancer Early Detection Program (BKFP) has officially started in January 2014. In order to ensure that all participating women can rely on a sufficient cancer detection rate while at the same time the required dose is as low as reasonably achievable, all participating radiology institutes (approx. 200) have to fulfill strict quality assurance requirements. The control and certification is performed by the Reference Center for Technical Quality Assurance (RefZQS), which has been developing the methods and tolerances in a pilot project since 2007. The limits are defined in the EUREF-Oeprotocol which is based on the European EPQC guidelines. From the requirement for optimized image quality while simultaneously following the ALARA principle, we found modality-dependent dose requirements, which we had expected but which have now been compiled for the first time for Austria.

  7. Aggregation induced Raman scattering of squaraine dye: Implementation in diagnosis of cervical cancer dysplasia by SERS imaging.

    Science.gov (United States)

    Narayanan, Nisha; Karunakaran, Varsha; Paul, Willi; Venugopal, Karunakaran; Sujathan, K; Kumar Maiti, Kaustabh

    2015-08-15

    The extent of squaraine dye aggregation that reflects on surface enhanced Raman signal scattering (SERS) intensity upon adsorption on nano-roughened gold surface has been investigated. Here we have synthesized a serious of six squaraine dyes consisting of two different electron donor moiety i.e. 1,1,2-trimethyl-1H-benzo[e]indole and 2-methylbenzo[d]thiazole which modulates the chemisorptions and hydrophobicity being designated as SQ1, SQ2, SQ3, SQ4, SQ5 and SQ6. Interestingly, SQ2 (mono lipoic acid appended), SQ5 and SQ6 (conjugated with hexyl and dodecyl side chain) squaraine derivatives having more tendency of aggregation in DMSO-water mixed solvent showed significant increase of Raman scattering in the fingerprint region when chemisorbed on spherical gold nanoparticles. Two sets of SERS nanotags were prepared with colloidal gold nanoparticle (Au-NPs size: 40 nm) by incorporating Raman reporters SQ2 and SQ5 followed by thiolated PEG encapsulation (SH-PEG, SH-PEG-COOH) denoted as AuNPs-SQ2-PEG and AuNPs-SQ5-PEG. Further conjugation of these nanotag with monoclonal antibodies specific to over expressed receptors, EGFR and p16/Ki-67 in cervical cancer cell, HeLa showed prominent SERS mapping intensity and selectivity towards cell surface and nucleus. The fast and accurate recognition obtained by antibody triggered SERS-nanotag has been compared with conventional time consuming immunocytochemistry technique which prompted us to extend further investigation using real patient cervical smear sample for a non-invasive, ultrafast and accurate diagnosis.

  8. Technical cooperation report for 2003. Report by the Director General

    International Nuclear Information System (INIS)

    all parts of the Secretariat. Nuclear medicine projects increased the availability of cancer diagnosis and treatment and improved the radiation protection of patients and technicians. Local consumption and export of crops from developing countries have been increased with support from the Agency through the use of the sterile insect technique as well as improved varieties of fruits and legumes resistant to disease and drought. Achievements in identifying water resources and mapping aquifer flows were also made using isotope hydrology methods. In the Europe region, the Agency contributed to returning high enriched uranium fuel to the country of origin and converting research reactor fuel to low-enriched uranium. In addition, upgrading radiation protection infrastructures in all regions has had continued success. The year had many accomplishments, as well as challenges. Early in 2003, the severe acute respiratory syndrome (SARS) erupted in the East Asia and the Pacific region, halting workshops and training sessions for a period of time. Security-related issues also hampered programme implementation in several regions. In addition, the unpredictability of payments to the Technical Cooperation Fund put into question the implementation of the full programme planned for 2003-2004. As a result of a shortfall in resources to the Technical Cooperation Fund at the end of 2003, the 2004 technical cooperation programme had to be reduced and the Board was asked to authorize an increase in over programming to 20% through June 2004.Thanks to significant efforts by a number of Member States during the first quarter of 2004, additional payments to the Technical Cooperation Fund for 2003 were made, resulting in a rate of attainment of 86.8% as of 31 March 2004. In addition, Member States made efforts to pay their target shares for 2004 earlier than has been the practice in the past. This permitted the Secretariat to restore many of the activities that had been postponed or cancelled

  9. Development and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells.

    Science.gov (United States)

    Johnston, Paul A; Nguyen, Minh M; Dar, Javid A; Ai, Junkui; Wang, Yujuan; Masoodi, Khalid Z; Shun, Tongying; Shinde, Sunita; Camarco, Daniel P; Hua, Yun; Huryn, Donna M; Wilson, Gabriela Mustata; Lazo, John S; Nelson, Joel B; Wipf, Peter; Wang, Zhou

    2016-05-01

    Patients with castration-resistant prostate cancer (CRPC) can be treated with abiraterone, a potent inhibitor of androgen synthesis, or enzalutamide, a second-generation androgen receptor (AR) antagonist, both targeting AR signaling. However, most patients relapse after several months of therapy and a majority of patients with relapsed CRPC tumors express the AR target gene prostate-specific antigen (PSA), suggesting that AR signaling is reactivated and can be targeted again to inhibit the relapsed tumors. Novel small molecules capable of inhibiting AR function may lead to urgently needed therapies for patients resistant to abiraterone, enzalutamide, and/or other previously approved antiandrogen therapies. Here, we describe a high-throughput high-content screening (HCS) campaign to identify small-molecule inhibitors of AR nuclear localization in the C4-2 CRPC cell line stably transfected with GFP-AR-GFP (2GFP-AR). The implementation of this HCS assay to screen a National Institutes of Health library of 219,055 compounds led to the discovery of 3 small molecules capable of inhibiting AR nuclear localization and function in C4-2 cells, demonstrating the feasibility of using this cell-based phenotypic assay to identify small molecules targeting the subcellular localization of AR. Furthermore, the three hit compounds provide opportunities to develop novel AR drugs with potential for therapeutic intervention in CRPC patients who have relapsed after treatment with antiandrogens, such as abiraterone and/or enzalutamide. PMID:27187604

  10. Discussion on Technical Solutions of Implementation of the Rehabilitation and Water-saving Rebuilding Program of Xingxingshao Irrigated Area%浅谈星星哨灌区节水配套改造项目实施技术方案

    Institute of Scientific and Technical Information of China (English)

    王菲

    2011-01-01

    论述了星星哨灌区节水配套改造项目实施技术方案,给今后类似工程提出设计、施工及监理的参考依据.%Technical solutions of implementation of the rehabilitation and water-saving rebuilding program of Xingxingshao irrigated area were discussed, and reference basis of design, construction and supervision was proposed combined with the similar projects in future.

  11. The technical feasibility of an image-guided intensity-modulated radiotherapy (IG-IMRT) to perform a hypofractionated schedule in terms of toxicity and local control for patients with locally advanced or recurrent pancreatic cancer

    International Nuclear Information System (INIS)

    The purpose of this study was to evaluate the technical feasibility of an image-guided intensity modulated radiotherapy (IG-IMRT) using involved-field technique to perform a hypofractionated schedule for patients with locally advanced or recurrent pancreatic cancer. From May 2009 to November 2011, 12 patients with locally advanced or locally recurrent pancreatic cancer received hypofractionated CCRT using TomoTherapy Hi-Art with concurrent and sequential chemotherapy at Seoul St. Mary’s Hospital, the Catholic University of Korea. The total dose delivered was 45 Gy in 15 fractions or 50 Gy in 20 fractions. The target volume did not include the uninvolved regional lymph nodes. Treatment planning and delivery were performed using the IG-IMRT technique. The follow-up duration was a median of 31.1 months (range: 5.7-36.3 months). Grade 2 or worse acute toxicities developed in 7 patients (58%). Grade 3 or worse gastrointestinal and hematologic toxicity occurred in 0% and 17% of patients, respectively. In the response evaluation, the rates of partial response and stable disease were 58% and 42%, respectively. The rate of local failure was 8% and no regional failure was observed. Distant failure was the main cause of treatment failure. The progression-free survival and overall survival durations were 7.6 and 12.1 months, respectively. The involved-field technique and IG-IMRT delivered via a hypofractionated schedule are feasible for patients with locally advanced or recurrent pancreatic cancer

  12. TECHNICAL COORDINATION

    CERN Multimedia

    A. Ball

    2010-01-01

    Operational Experience Since the closure of the detector in February, the technical operation of CMS has been quite smooth and reliable. Some minor interventions in UXC were required to cure failures of power supplies, fans, readout boards and rack cooling connections, but all these failures were repaired in scheduled technical stops or parasitically during access dedicated to fixing LHC technical problems. The only occasion when CMS had to request an access between fills was to search for the source of an alarm from the leak-detection cables mounted in the DT racks. After a few minutes of diagnostic search, a leaking air-purge was found. Replacement was complete within 2 hours. This incident demonstrated once more the value of these leak detection cables; the system will be further extended (during the end of year technical stop) to cover more racks in UXC and the floor beneath the detector. The magnet has also been operating reliably and reacted correctly to the 14s power cut on 29 May (see below). In or...

  13. Imagining Technicities

    DEFF Research Database (Denmark)

    Liboriussen, Bjarke; Plesner, Ursula

    2011-01-01

    The actors of the building industry have access to a range of Information and Communication Technologies (ICTs), and are constantly presented with new software and new communications platforms. Through case studies, and inspired by sociotechnical approaches to the study of emerging technologies, ...... in cooperation and development of ICTs seems to pass unnoticed. However, since they are aligned into ICTs, technicities impact innovation....

  14. TECHNICAL COORDINATION

    CERN Multimedia

    A. Ball

    2010-01-01

    Operational Experience At the end of the first full-year running period of LHC, CMS is established as a reliable, robust and mature experiment. In particular common systems and infrastructure faults accounted for <0.6 % CMS downtime during LHC pp physics. Technical operation throughout the entire year was rather smooth, the main faults requiring UXC access being sub-detector power systems and rack-cooling turbines. All such problems were corrected during scheduled technical stops, in the shadow of tunnel access needed by the LHC, or in negotiated accesses or access extensions. Nevertheless, the number of necessary accesses to the UXC averaged more than one per week and the technical stops were inevitably packed with work packages, typically 30 being executed within a few days, placing a high load on the coordination and area management teams. It is an appropriate moment for CMS Technical Coordination to thank all those in many CERN departments and in the Collaboration, who were involved in CMS techni...

  15. Technical Training: Technical Training Seminar

    CERN Multimedia

    2004-01-01

    TECHNICAL TRAINING Monique Duval tel. 74924 technical.training@cern.ch Monday 9 February 2004 From 10:00 to 12:00 - IT Auditorium - bldg. 31, 3rd floor ANSOFT High-Frequency Seminar David Prestaux, Application Engineer, ANSOFT F-78535 BUC, France This Technical Training seminar will present two Ansoft application products: Ansoft HFSS and Ansoft Designer. Ansoft HFSS makes use of the Finite Element Method (FEM) to calculate field solutions from first principles. It can accurately predict all high-frequency behaviours such as dispersion, mode conversion, and losses due to materials and radiation. Ansoft Designer is a suite of design tools to fully integrate high-frequency, physics-based electromagnetic simulations into a seamless system-level simulation environment. Ansoft Designer uses a simple interface to give complete control over every design task, by a method allowing multiple solvers, Solver on Demand. • Introduction • Overview of the Ansoft Total solution • Ansoft HFSS 9...

  16. TH-C-12A-07: Implementation of a Pulsed Low Dose Date Radiotherapy (PLRT) Protocol for Recurrent Cancers Using Advanced Beam Delivery

    Energy Technology Data Exchange (ETDEWEB)

    Ma, C; Lin, M; Chen, L; Price, R [Fox Chase Cancer Center, Philadelphia, PA (United States); Li, J; Kang, S; Wang, P; Lang, J [Sichuan Provincial Cancer Hospital, Chengdu (China)

    2014-06-15

    Purpose: Recent in vitro and in vivo experimental findings provided strong evidence that pulsed low-dose-rate radiotherapy (PLDR) produced equivalent tumor control as conventional radiotherapy with significantly reduced normal tissue toxicities. This work aimed to implement a PLDR clinical protocol for the management of recurrent cancers utilizing IMRT and VMAT. Methods: Our PLDR protocol requires that the daily 2Gy dose be delivered in 0.2Gy×10 pulses with a 3min interval between the pulses. To take advantage of low-dose hyper-radiosensitivity the mean dose to the target is set at 0.2Gy and the maximum dose is limited to 0.4Gy per pulse. Practical planning strategies were developed for IMRT and VMAT: (1) set 10 ports for IMRT and 10 arcs for VMAT with each angle/arc as a pulse; (2) set the mean dose (0.2Gy) and maximum dose (0.4Gy) to the target per pulse as hard constraints (no constraints to OARs); (3) select optimal port/arc angles to avoid OARs; and (4) use reference structures in or around target/OARs to reduce maximum dose to the target/OARs. IMRT, VMAT and 3DCRT plans were generated for 60 H and N, breast, lung, pancreas and prostate patients and compared. Results: All PLDR treatment plans using IMRT and VMAT met the dosimetry requirements of the PLDR protocol (mean target dose: 0.20Gy±0.01Gy; maximum target dose < 0.4Gy). In comparison with 3DCRT, IMRT and VMAT exhibited improved target dose conformity and OAR dose sparing. A single arc can minimize the difference in the target dose due to multi-angle incidence although the delivery time is longer than 3DCRT and IMRT. Conclusion: IMRT and VMAT are better modalities for PLDR treatment of recurrent cancers with superior target dose conformity and critical structure sparing. The planning strategies/guidelines developed in this work are practical for IMRT/VMAT treatment planning to meet the dosimetry requirements of the PLDR protocol.

  17. Implementation of Constant Dose Rate and Constant Angular Spacing Intensity-modulated Arc Therapy for Cervical Cancer by Using a Conventional Linear Accelerator

    Science.gov (United States)

    Zhang, Ruo-Hui; Fan, Xiao-Mei; Bai, Wen-Wen; Cao, Yan-Kun

    2016-01-01

    Background: Volumetric-modulated arc therapy (VMAT) can only be implemented on the new generation linacs such as the Varian Trilogy® and Elekta Synergy®. This prevents most existing linacs from delivering VMAT. The purpose of this study was to investigate the feasibility of using a conventional linear accelerator delivering constant dose rate and constant angular spacing intensity-modulated arc therapy (CDR-CAS-IMAT) for treating cervical cancer. Methods: Twenty patients with cervical cancer previously treated with intensity-modulated radiation therapy (IMRT) using Varian Clinical 23EX were retreated using CDR-CAS-IMAT. The planning target volume (PTV) was set as 50.4 Gy in 28 fractions. Plans were evaluated based on the ability to meet the dose volume histogram. The homogeneity index (HI), target volume conformity index (CI), the dose to organs at risk, radiation delivery time, and monitor units (MUs) were also compared. The paired t-test was used to analyze the two data sets. All statistical analyses were performed using SPSS 19.0 software. Results: Compared to the IMRT group, the CDR-CAS-IMAT group showed better PTV CI (0.85 ± 0.03 vs. 0.81 ± 0.03, P = 0.001), clinical target volume CI (0.46 ± 0.05 vs. 0.43 ± 0.05, P = 0.001), HI (0.09±0.02 vs. 0.11 ± 0.02, P = 0.005) and D95 (5196.33 ± 28.24 cGy vs. 5162.63 ± 31.12 cGy, P = 0.000), and cord D2 (3743.8 ± 118.7 cGy vs. 3806.2 ± 98.7 cGy, P = 0.017) and rectum V40 (41.9 ± 6.1% vs. 44.2 ± 4.8%, P = 0.026). Treatment time (422.7 ± 46.7 s vs. 84.6 ± 7.8 s, P = 0.000) and the total plan Mus (927.4 ± 79.1 vs. 787.5 ± 78.5, P = 0.000) decreased by a factor of 0.8 and 0.15, respectively. The IMRT group plans were superior to the CDR-CAS-IMAT group plans considering decreasing bladder V50 (17.4 ± 4.5% vs. 16.6 ± 4.2%, P = 0.049), bowel V30 (39.6 ± 6.5% vs. 36.6 ± 7.5%, P = 0.008), and low-dose irradiation volume; there were no significant differences in other statistical indexes. Conclusions

  18. TECHNICAL COORDINATION

    CERN Multimedia

    A. Ball

    Overview From a technical perspective, CMS has been in “beam operation” state since 6th November. The detector is fully closed with all components operational and the magnetic field is normally at the nominal 3.8T. The UXC cavern is normally closed with the radiation veto set. Access to UXC is now only possible during downtimes of LHC. Such accesses must be carefully planned, documented and carried out in agreement with CMS Technical Coordination, Experimental Area Management, LHC programme coordination and the CCC. Material flow in and out of UXC is now strictly controlled. Access to USC remains possible at any time, although, for safety reasons, it is necessary to register with the shift crew in the control room before going down.It is obligatory for all material leaving UXC to pass through the underground buffer zone for RP scanning, database entry and appropriate labeling for traceability. Technical coordination (notably Stephane Bally and Christoph Schaefer), the shift crew and run ...

  19. TECHNICAL COORDINATION

    CERN Multimedia

    A. Ball and W. Zeuner

    2011-01-01

    In this report we will review the main achievements of the Technical Stop and the progress of several centrally-managed projects to support CMS operation and maintenance and prepare the way for upgrades. Overview of the extended Technical Stop  The principal objectives of the extended Technical Stop affecting the detector itself were the installation of the TOTEM T1 telescopes on both ends, the readjustment of the alignment link-disk in YE-2, the replacement of the light-guide sleeves for all PMs of both HFs, and some repairs on TOTEM T2 and CASTOR. The most significant tasks were, however, concentrated on the supporting infrastructure. A detailed line-by-line leak search was performed in the C6F14 cooling system of the Tracker, followed by the installation of variable-frequency drives on the pump motors of the SS1 and SS2 tracker cooling plants to reduce pressure transients during start-up. In the electrical system, larger harmonic filters were installed in ...

  20. Technical Training: Technical Training Seminar

    CERN Multimedia

    2004-01-01

    Tuesday 30 March TECHNICAL TRAINING SEMINAR From 9:00 to 12:00 and from 13:00 to 16:00 hrs - Council Chamber, Salle B, Salle des Pas Perdus National Instruments (NI) on Tour 2004 Claudia Jüngel, Evrem Yarkin, Joel Clerc, Hervé Baour / NATIONAL INSTRUMENTS The special event NI on Tour 2004, run in Germany, Austria and Switzerland, will be at CERN on March 30. Technical seminars and free introductory courses will be offered all day long in the Council Chamber, Salle B, and Salle des Pas Perdus (buildings 61 and 503). Technical conferences: 09:00 - 12:00 Data acquisition systems on PCs. Industrial measurement and control techniques. 13:00 - 16:00 Advanced LabVIEW software and PXI instrumentation. Measuring instruments and system components for teststand automation. Introductory courses: 09:00 - 12:00 DIAdem: Data analysis and presentation 13:00 - 16:00 Data acquisition with LabVIEW Language: English and French Free special seminar. Registration is recommended with National Instruments Switzerland (please sp...

  1. Technical Training: Technical Training Seminar

    CERN Multimedia

    2004-01-01

    Tuesday 30 March TECHNICAL TRAINING SEMINAR From 9:00 to 12:00 and from 13:00 to 16:00 hrs - Council Chamber, Salle B, Salle des Pas Perdus National Instruments (NI) on Tour 2004 Claudia Jüngel, Evrem Yarkin, Joel Clerc, Hervé Baour / NATIONAL INSTRUMENTS The special event NI on Tour 2004, run in Germany, Austria and Switzerland, will be at CERN on March 30. Technical seminars and free introductory courses will be offered all day long in the Council Chamber, Salle B, and Salle des Pas Perdus (buildings 61 and 503). Technical conferences: 09:00 - 12:00 Data acquisition systems on PCs. Industrial measurement and control techniques. 13:00 - 16:00 Advanced LabVIEW software and PXI instrumentation. Measuring instruments and system components for teststand automation. Introductory courses: 09:00 - 12:00 DIAdem: Data analysis and presentation 13:00 - 16:00 Data acquisition with LabVIEW Language: English and French Free special seminar. Registration is recommended with National Instruments Swi...

  2. Cancer Basics

    Science.gov (United States)

    ... Cancer? Breast Cancer Colon/Rectum Cancer Lung Cancer Prostate Cancer Skin Cancer Show All Cancer Types News and Features Cancer Glossary ACS Bookstore Cancer Information Cancer Basics Cancer Prevention & Detection Signs & Symptoms of Cancer Treatments & Side Effects ...

  3. BWR feedwater nozzle and control rod drive return line nozzle cracking: resolution of generic technical activity A-10. Technical report

    International Nuclear Information System (INIS)

    This report summarizes work performed by the NRC staff in the resolution of Generic Technical Activity A-10, 'BWR Nozzle Cracking'. Generic Technical Activity A-10 is one of the generic technical subjects designated as 'unresolved safety issues' pursuant to Section 210 of the Energy Reorganization Act of 1974. The report describes the technical issues, the technical studies and analyses performed by the General Electric Company and the NRC staff, the staff's technical positions based on these studies, and the staff's plans for continued implementation of its technical positions. It also provides information for further work to resolve the non-destructive examination issue

  4. TECHNICAL COORDINATION

    CERN Multimedia

    A. Ball and W. Zeuner

    2011-01-01

      Operational experience 2011 CMS is approaching the end of a very successful year of operation. Proton- proton running ended in the late afternoon of 30th October with a stunning 5.73 fb–1 delivered by LHC, of which CMS recorded 5.22 fb–1. During heavy-ion operation, which continues until 7th December, both the accelerator and the CMS detector have also performed very well. Despite the encouraging overall reliability of technical operation, several infrastructure failures which occurred since the last Bulletin are worthy of mention, with one leading for the first time to significant data-loss. On 10th July, a CERN-wide power failure brought down essentially all services including the magnet, due to an MCS setting being left in “manual” after the recent technical stop, but there was no significant damage and the detector was operational before the LHC, despite a slow and tortuous recovery (one of several indications this year that there is room for improve...

  5. TECHNICAL COORDINATION

    CERN Multimedia

    Austin Ball

    Summary of progress since last CMS week. Ten years of construction work have been completed. CMS is closed, in very close to the ideal low luminosity configuration, and performed well in the first tests with LHC beam. Behind this encouraging news is the story of a summer of intense commitment by many teams (from the collaboration and 3 CERN departments) working together, against the clock and despite many minor setbacks, to ensure that the experiment was ready to play a leading role in the excitement of September 10. Following beampipe bakeout and refill with pure neon, a magnificent effort by the ECAL group and the pt 5 technical crew made it possible to install and commission all 4 ECAL endcap Dees before the end of August. In the shadow of this activity, the barrel and forward pixel trackers and part of the beam monitoring were installed within the vac tank. The pt 5 technical teams then succeeded in safely removing the 20t installation tables and their support blocks from beneath the already installed ...

  6. TECHNICAL COORDINATION

    CERN Multimedia

    A. Ball and W. Zeuner

    2013-01-01

    For the reporting period, the CMS common systems and infrastructure worked well, without failures that caused significant data losses. One more disconnection of the magnet cold box occurred in the shadow of interruptions in data taking, caused by a series of technical faults. The recognition during 2012 that re-connection can only safely be done at around 2 T implies a minimum magnet recovery time of 12 hours and raises serious concerns about the number of ramping cycles of the magnet these incidents cause. This has triggered studies of how to make the cryo-system of the magnet more robust against failures. The proton-proton run ended just before the end-of-year CERN closure, during which CASTOR was installed on the negative end of CMS and both ZDC calorimeters were installed in TAN absorbers the LHC tunnel, in preparation for the heavy-ion run. The installation of CASTOR was an excellent “engineering test” of procedures for working in an activated environment. Despite some technical pr...

  7. Technical economic feasibility study for the implementation of a nuclear power plant for the production of electricity in Colombia; Estudio de factibilidad tecnico economica para la implementacion de una central de energia nuclear para la produccion de energia electrica en Colombia

    Energy Technology Data Exchange (ETDEWEB)

    Gonzales, David E.; Bolanos, Hernan G.; Mayorga, Manuel A.; Rodriguez, Edwin A., E-mail: david_egO@yahoo.es, E-mail: hernanbolaos@yahoo.com.ar, E-mail: alejo_mayorga@yahoo.com, E-mail: edwin.rodriguez@distoyota.com.co [Escuela Colombiana de Carreras Industriales (ECCI), Bogota (Colombia). Grupo de Investigacion GIATME

    2013-07-01

    A study on the technical and economic feasibility will be used to implement a nuclear power in Colombia to generate electricity. To this will be searched if there are previous studies on this topic and what they concluded. The manner in which power is supplied will be discussed in a national level nowadays, its strengths and weaknesses. It will be investigated the legal norms that exists in the country on nuclear power and renewable energy sources, the standards established at world level, the nuclear accidents and the great examples. Providers will be sought on the world market nuclear equipment which serve to this purpose and the technical characteristics of these equipment will be discussed. The type of fuel used in nuclear reactors, its origin, method of production, specifications, availability and long-term and safe handling and final disposal are considered. safe handling of this technology and policy or international rules that will studied.

  8. Evaluation of modular education program implementation in vocational and technical high schools Mesleki ve teknik liselerde uygulanan modüler öğretim programının değerlendirilmesi

    Directory of Open Access Journals (Sweden)

    Subhan Ekşioğlu

    2014-11-01

    Full Text Available The aim of this study is to evaluate the modular educational program implemented at vocational high schools and to describe the problems in this program. The study is based on the Erden’s Evaluation Model Regarding Curriculum Components. The model of the study is descriptive study. The data were gathered through two different models by using three different sources: The quantitative data were collected from 430 teachers and 903 students at 48 vocational and technical high schools in Turkey. The questionnaires developed by the researcher were given to collect the quantitative data from teachers and students. In order to analyze the data, computer data analysis program was used. When there is a normal distribution independent sample and paired sample t tests and when there is not a normal distribution, Mann Whitney U and Wilcoxon tests were conducted. The qualitative data were gathered from 15 specialists working at Ministry of National Education and universities. Semi-structured interview forms were used to collect this type of data. The findings of this study are: The objectives of the modular educational program implemented at vocational high schools are clear, comprehensible and can be expressed behaviorally. At the same time, the objectives of the program are preparing the students to their jobs. Some modules have a rich knowledge transition which contradicts with the notion of this program. The activities related with teaching and learning process are partially sufficient. However, the teaching-learning process cannot be achieved because of some regulation problems. The most important problem in the evaluation part of the program is the rules and regulations being effect. If some changes are done in the rules and regulations, the evaluation part of the program could be more effective. According to this, it may be beneficial to make the practices of vocational analysis constant, place modules appropriate for contemporary vocations in the

  9. Technical approach document

    Energy Technology Data Exchange (ETDEWEB)

    1989-12-01

    The Uranium Mill Tailings Radiation Control Act (UMTRCA) of 1978, Public Law 95-604 (PL95-604), grants the Secretary of Energy the authority and responsibility to perform such actions as are necessary to minimize radiation health hazards and other environmental hazards caused by inactive uranium mill sites. This Technical Approach Document (TAD) describes the general technical approaches and design criteria adopted by the US Department of Energy (DOE) in order to implement remedial action plans (RAPS) and final designs that comply with EPA standards. It does not address the technical approaches necessary for aquifer restoration at processing sites; a guidance document, currently in preparation, will describe aquifer restoration concerns and technical protocols. This document is a second revision to the original document issued in May 1986; the revision has been made in response to changes to the groundwater standards of 40 CFR 192, Subparts A--C, proposed by EPA as draft standards. New sections were added to define the design approaches and designs necessary to comply with the groundwater standards. These new sections are in addition to changes made throughout the document to reflect current procedures, especially in cover design, water resources protection, and alternate site selection; only minor revisions were made to some of the sections. Sections 3.0 is a new section defining the approach taken in the design of disposal cells; Section 4.0 has been revised to include design of vegetated covers; Section 8.0 discusses design approaches necessary for compliance with the groundwater standards; and Section 9.0 is a new section dealing with nonradiological hazardous constituents. 203 refs., 18 figs., 26 tabs.

  10. Technical approach document

    International Nuclear Information System (INIS)

    The Uranium Mill Tailings Radiation Control Act (UMTRCA) of 1978, Public Law 95-604 (PL95-604), grants the Secretary of Energy the authority and responsibility to perform such actions as are necessary to minimize radiation health hazards and other environmental hazards caused by inactive uranium mill sites. This Technical Approach Document (TAD) describes the general technical approaches and design criteria adopted by the US Department of Energy (DOE) in order to implement remedial action plans (RAPS) and final designs that comply with EPA standards. It does not address the technical approaches necessary for aquifer restoration at processing sites; a guidance document, currently in preparation, will describe aquifer restoration concerns and technical protocols. This document is a second revision to the original document issued in May 1986; the revision has been made in response to changes to the groundwater standards of 40 CFR 192, Subparts A--C, proposed by EPA as draft standards. New sections were added to define the design approaches and designs necessary to comply with the groundwater standards. These new sections are in addition to changes made throughout the document to reflect current procedures, especially in cover design, water resources protection, and alternate site selection; only minor revisions were made to some of the sections. Sections 3.0 is a new section defining the approach taken in the design of disposal cells; Section 4.0 has been revised to include design of vegetated covers; Section 8.0 discusses design approaches necessary for compliance with the groundwater standards; and Section 9.0 is a new section dealing with nonradiological hazardous constituents. 203 refs., 18 figs., 26 tabs

  11. Cellular spectroscopy: applications to cancer stem cell characterization

    Science.gov (United States)

    Wiegand, G.; Xin, H.; Anderson, A.; Mullinax, J.; Jaiswal, K.; Wiegand, A.; Avital, Itzhak

    2011-02-01

    Spectroscopic and light scattering methods were used to gain insight into the existence and characterization of the cancer stem cell. Fundamental technical description of devices used have been reported elsewhere. We included alterations and implementation of these biophotonic instruments as applied to our objectives. We disassociated human tumor and submitted the cells to optical characterization to support our working hypothesis of stem cell origins to cancer and mechanisms. Single cell combined with population based analysis within the Pancreatic cancer system led us to information regarding the polarization state of cells possessing anchor proteins and drug influx pumps. Multispectral imaging combined with flow cytometry enabled us to target rare cells that appear to retain template DNA. rendering them resistant to anti-cancer drug therapy. In this study we describe an optical method that combines high-throughput population pattern and correlates each cell with an individual fluorescent and bright-field image.

  12. Recommendations for implementing stereotactic radiotherapy in peripheral stage IA non-small cell lung cancer: report from the Quality Assurance Working Party of the randomised phase III ROSEL study

    International Nuclear Information System (INIS)

    A phase III multi-centre randomised trial (ROSEL) has been initiated to establish the role of stereotactic radiotherapy in patients with operable stage IA lung cancer. Due to rapid changes in radiotherapy technology and evolving techniques for image-guided delivery, guidelines had to be developed in order to ensure uniformity in implementation of stereotactic radiotherapy in this multi-centre study. A Quality Assurance Working Party was formed by radiation oncologists and clinical physicists from both academic as well as non-academic hospitals that had already implemented stereotactic radiotherapy for lung cancer. A literature survey was conducted and consensus meetings were held in which both the knowledge from the literature and clinical experience were pooled. In addition, a planning study was performed in 26 stage I patients, of which 22 were stage 1A, in order to develop and evaluate the planning guidelines. Plans were optimised according to parameters adopted from RTOG trials using both an algorithm with a simple homogeneity correction (Type A) and a more advanced algorithm (Type B). Dose conformity requirements were then formulated based on these results. Based on current literature and expert experience, guidelines were formulated for this phase III study of stereotactic radiotherapy versus surgery. These guidelines can serve to facilitate the design of future multi-centre clinical trials of stereotactic radiotherapy in other patient groups and aid a more uniform implementation of this technique outside clinical trials

  13. TECHNICAL COORDINATION

    CERN Document Server

    A. Ball and W. Zeuner

    2010-01-01

    Overview Once again, the bulk of this article reviews the intense activity of a recently completed shutdown, which, although quite unforeseeable until a few weeks before it started, proved by its success that our often advertised capability to conduct major maintenance within a two month period is real. Although safely completed, on-time to remarkable precision, the activity was not without incident, and highlighted our dependence on many experienced, specialist teams and their precise choreography. Even after the yoke was safely closed, magnet re-commissioning and beampipe pumpdown showed new and thought-provoking behaviour. The struggle to maintain adequate technical resources will be a pre-occupation over the coming months, in parallel with the start of truly sustained operation, for which various procedures are still being put in place. Planning for future shutdowns must now become a high priority, with many working groups and task forces already in existence to prepare infrastructure improvements and to...

  14. Technical presentation

    CERN Multimedia

    GS Department

    2010-01-01

    10 March 2010 DYNEOS 10:00 – 12:00 - Main Building, Room B, 61-1-009 Dyneos AG is active in the fields of photonics, laser and high-precision positioning. Our highly qualified engineer team has more than 30 years of experience in electro-optical solutions sales. The engineers are supported by a technical and administrative team. We are focused on the Swiss market and represent six suppliers (Coherent, PI Physik Instrumente, SIOS, Nanonics Imaging, APE, Ekspla) in order to give a qualified sales and service support to our customers. Our products are dedicated to the research field as well as to industry. In addition to standard catalog products, we offer custom designs to fulfill the specific needs of OEM customers or specific applications.

  15. Technical presentation

    CERN Multimedia

    FP Department

    2009-01-01

    07 April 2009 Technical presentation by Leuze Electronics: 14.00 – 15.00, Main Building, Room 61-1-017 (Room A) Photoelectric sensors, data identification and transmission systems, image processing systems. We at Leuze Electronics are "the sensor people": we have been specialising in optoelectronic sensors and safety technology for accident prevention for over 40 years. Our dedicated staff are all highly customer oriented. Customers of Leuze Electronics can always rely on one thing – on us! •\tFounded in 1963 •\t740 employees •\t115 MEUR turnover •\t20 subsidiaries •\t3 production facilities in southern Germany Product groups: •\tPhotoelectric sensors •\tIdentification and measurements •\tSafety devices

  16. Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients

    DEFF Research Database (Denmark)

    Győrffy, Balázs; Lánczky, András; Szállási, Zoltán

    2012-01-01

    ). A Kaplan–Meier survival plot was generated and significance was computed. The tool can be accessed online at www.kmplot.com/ovar. We used this integrative data analysis tool to validate the prognostic power of 37 biomarkers identified in the literature. Of these, CA125 (MUC16; P=3.7x10–5, hazard...... biomarker validation platform that mines all available microarray data to assess the prognostic power of 22 277 genes in 1287 ovarian cancer patients. We specifically used this tool to evaluate the effect of 37 previously published biomarkers on ovarian cancer prognosis....... set up using gene expression data and survival information of 1287 ovarian cancer patients downloaded from Gene Expression Omnibus and The Cancer Genome Atlas (Affymetrix HG-U133A, HG-U133A 2.0, and HG-U133 Plus 2.0 microarrays). After quality control and normalization, only probes present on all...

  17. Technical Training: Technical Training Seminar

    CERN Multimedia

    2004-01-01

    TECHNICAL TRAINING Monique Duval tel. 74924 technical.training@cern.ch Tuesday 3 February 2004 From 09:00 to 13:30 - Training Centre Auditorium - bldg. 593, room 11 USB (Universal Serial Bus) CYPRESS Seminar Claudia Colombini, Field Application Engineer CYPRESS ActiveComp Electronic GmbH D-85077 MANCHING, Germany As a pioneer in USB, CYPRESS sets the standard for cost-effective solutions without sacrificing functionality, performance or reliability. Having shipped over 200 million USB devices, Cypress is the undisputed market leader and demonstrates unmatched USB expertise. With the industry's broadest selection of USB solutions, Cypress has the right silicon, software and support for every USB application, from Low-speed to High-Speed and USB On-The-Go (OTG). 9:00 - 10:30 Overview of USB systems. USB CYPRESS product overview. Peripherals: Low Speed, Full Speed, High Speed (1.1 and 2.0). Hub Solutions, Embedded Host Solutions, On-The-Go (OTG) and wireless USB. USB Development Tools (first part) 10:30 -...

  18. Technical aspects of data communication

    CERN Document Server

    MacNamara, John E

    1988-01-01

    Technical Aspects of Data Communication, Third Edition provides information pertinent to the technical aspects of data communication. This book discusses a simple asynchronous interface implemented with a specialized integrated circuit called a UART.Organized into 28 chapters, this edition begins with an overview of the interface standards ranging from the classic EIA-232-D to the EIA-530. This text then describes modems and modem control, with material on high-speed modems and error-correcting modems. Other chapters discuss hardware and software methods. This book discusses as well digital tr

  19. An Input Evaluation of Three Technical Assistance Needs Assessment Strategies.

    Science.gov (United States)

    Suarez, Tanya M.; Cox, James O.

    The Technical Assistance Development System--TADS (a project to provide technical assistance to personnel implementing programs for preschool handicapped children and their families) conducted an evaluation of three technical assistance needs assessment strategies during 1979-80. The three strategies were: (1) on-site--conducted by a trained needs…

  20. Technical note: Evaluation of the uncertainties in (choline+creatine)/citrate ratios measured by proton MR spectroscopic imaging in patients suspicious for prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Zbyn, S.; Krssak, M.; Memarsadeghi, M.; Gholami, B.; Haitel, A.; Weber, M.; Helbich, T.H.; Trattnig, S.; Moser, E.; Gruber, S.

    2014-07-15

    The presented evaluation of the relative uncertainty (δ'CCC) of the (choline + creatine)/citrate (CC/C) ratios can provide objective information about the quality and diagnostic value of prostate MR spectroscopic imaging data. This information can be combined with the numeric values of CC/C ratios and provides metabolic-quality maps enabling accurate cancer detection and user-independent data evaluation. In addition, the prostate areas suffering most from the low precision of CC/C ratios (e. g., prostate base) were identified.

  1. U.S. technical specification improvement program

    International Nuclear Information System (INIS)

    The U.S. Nuclear Community has underway an extensive Technical Specification improvement effort. The overall goal of the effort is to improve operational safety by simplifying the Technical Specifications, making them more usable by the operators, and providing a clear link between the technical requirements and their safety significance. This will allow the operators and plant staff to focus on the more risk significant requirements. General improvements are being made to both the overall format and content of Technical Specifications as well as to specific technical requirements within the specifications. The focal point for making these improvements is the recently issued Commission Policy Statement on Technical Specification Improvements. Implementing this Policy Statement will result in new Standard Technical Specifications for each of the four U.S. nuclear steam supply system vendors, new standards which we believe will be adopted at a significant number of the nuclear power plants in our country. This presentation briefly describes some of the Technical Specification problems encountered, some of the studies that were done and recommendations that were made to correct these problems. Details are given about the NRC Policy Statement on Technical Specification Improvements and how it will be implemented

  2. Pilot implementation

    DEFF Research Database (Denmark)

    Hertzum, Morten; Bansler, Jørgen P.; Havn, Erling C.;

    2012-01-01

    implementation and provide three empirical illustrations of our model. We conclude that pilot implementation has much merit as an ISD technique when system performance is contingent on context. But we also warn developers that, despite their seductive conceptual simplicity, pilot implementations can be difficult...

  3. A detailed report of the resource use and costs associated with implementation of a short stay programme for breast cancer surgery

    NARCIS (Netherlands)

    Ament, S.M.; Kok, M. de; Velde, C.J. van de; Roukema, J.A.; Bell, T.V.; Ent, F.W. van der; Weijden, T.T. van der; Meyenfeldt, M.F. von; Dirksen, C.D.

    2015-01-01

    BACKGROUND: Despite the increased attention for assessing the effectiveness of implementation strategies, most implementation studies provide little or no information on its associated costs. The focus of the current study was to provide a detailed report of the resource use and costs associated wit

  4. Towards a review of the EC Recommendation for a definition of the term "nanomaterial": Part 3: Scientific-technical evaluation of options to clarify the definition and to facilitate its implementation

    OpenAIRE

    Rauscher, Hubert; Roebben, Gert; BOIX SANFELIU Ana; Emons, Hendrik; Gibson, Peter; KOEBER Robert; Linsinger, Thomas; Rasmussen, Kirsten; RIEGO SINTES Juan; SOKULL-KLUETTGEN Birgit; STAMM Hermann

    2015-01-01

    This report provides the JRC's scientific-technical evaluation of options to clarify the EC Recommendation on a definition of nanomaterial, published in 2011 (EC Recommendation 2011/696/EU). It is a follow-up report of two previous JRC publications, which compiled feedback on the experiences of stakeholders with the EC nanomaterial definition collected by JRC in 2013 and early 2014 (EUR 26567 EN, 2014), and provided an assessment of the collected information (EUR 26744 EN, 2014). The three JR...

  5. American Recovery and Reinvestment Act (ARRA) FEMP Technical Assistance U.S. Army – Project 214 Analysis of Regulations Associated with Implementation of a Rocky Mountain Secure Smart-Grid

    Energy Technology Data Exchange (ETDEWEB)

    Warwick, William M.

    2010-09-30

    This document describes technical assistance provided by PNNL to further develop a smart grid technologies concept to provide a basis for policies and plans for the US Army. The effort was to analyze the potential to utilize emerging smart grid technologies along with indigenous renewable and other resources to meet the emergency and other power needs of Department of Defense facilities in Colorado and Wyoming.

  6. Technical innovation and management

    International Nuclear Information System (INIS)

    This book gives explanations of the conception of technical innovation, development plan in Korea, connection between technology and a growth factor in national income, problem of technical innovation in developing country, analysis on cooperation between a developed country and a developing country, evaluation and strategy of technical development in Korea, technical innovation of industry, management of technical industry, analysis of special condition in Korea.

  7. How should we discuss genetic testing with women newly diagnosed with breast cancer? Design and implementation of a randomized controlled trial of two models of delivering education about treatment-focused genetic testing to younger women newly diagnosed with breast cancer

    Directory of Open Access Journals (Sweden)

    Watts Kaaren J

    2012-07-01

    making; and decision regret. A process-oriented retrospective online survey will examine health professionals’ attitudes toward TFGT; a health economic analysis will determine the cost effectiveness of the intervention. Discussion This trial will provide crucial information about the impact, efficiency and cost effectiveness of an educational pamphlet designed to inform younger women newly diagnosed with breast cancer about genetic testing. Issues regarding implementation of the trial are discussed. Trial registration The study is registered with the Australian and New Zealand Clinical Trials Group (Registration no: ACTRN12610000502033

  8. TECHNICAL COORDINATION

    CERN Multimedia

    A. Ball and W. Zeuner

    2012-01-01

      UXC + detectors As explained in detail in the November 2011 bulletin, the bellows unit at −18.5 m from the CMS interaction point was identified as a prime candidate for the regularly occurring pressure spikes which occasionally led to sustained severe background conditions in 2011, affecting dead time and data quality. Similar regions in LHC with vacuum instabilities were observed to be close to bellows, which radiography showed to have distorted RF-fingers — on removal, they proved to have been severely overheated. The plans for the Year-End Technical Stop were adapted to prioritise radiography of the bellows at 16 m to 18 m either end of CMS. Excellent work by the beam pipe, survey and heavy mechanical teams allowed the X-rays to be taken as planned on 20th December, showing that the bellow at −18.5m had an obvious non-conformity. The RF-fingers were found inside the end of the opposing flared pipe instead of outside. In addition, the overlap between fingers and...

  9. TECHNICAL COORDINATION

    CERN Multimedia

    Austin Ball

    2013-01-01

      Since the last report, much visible progress has been made, as the LS1 programme approaches the halfway point. From early October, technical and safety shift-crew have been present around the clock, allowing detectors to stay switched on overnight, ensuring that safety systems are operational and instructions for non-expert shift-crew are clear. LS1 progress Throughout the summer, whilst the solenoid vacuum tank and YB0 surfaces were accessible, an extensive installation programme took place to prepare for Tracker colder operation and the PLT installation, in 2014, the Phase 1 Pixel Tracker installation, in 2016–’17, and the HCAL Phase 1 upgrade completion, ending in LS2. This included pipework for N2 or dry air to flush the Tracker bulkhead region, many sensors to monitor temperature and dew point in the Tracker and its service channels, heating wires outside the Tracker cooling bundles, supports for the new vacuum-jacketed, concentric, CO2 Pixel cooling lines, the PLT cool...

  10. A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers.

    LENUS (Irish Health Repository)

    Hennessy, Bryan T

    2010-12-01

    INTRODUCTION: The lack of large panels of validated antibodies, tissue handling variability, and intratumoral heterogeneity potentially hamper comprehensive study of the functional proteome in non-microdissected solid tumors. The purpose of this study was to address these concerns and to demonstrate clinical utility for the functional analysis of proteins in non-microdissected breast tumors using reverse phase protein arrays (RPPA). METHODS: Herein, 82 antibodies that recognize kinase and steroid signaling proteins and effectors were validated for RPPA. Intraslide and interslide coefficients of variability were <15%. Multiple sites in non-microdissected breast tumors were analyzed using RPPA after intervals of up to 24 h on the benchtop at room temperature following surgical resection. RESULTS: Twenty-one of 82 total and phosphoproteins demonstrated time-dependent instability at room temperature with most variability occurring at later time points between 6 and 24 h. However, the 82-protein functional proteomic "fingerprint" was robust in most tumors even when maintained at room temperature for 24 h before freezing. In repeat samples from each tumor, intratumoral protein levels were markedly less variable than intertumoral levels. Indeed, an independent analysis of prognostic biomarkers in tissue from multiple tumor sites accurately and reproducibly predicted patient outcomes. Significant correlations were observed between RPPA and immunohistochemistry. However, RPPA demonstrated a superior dynamic range. Classification of 128 breast cancers using RPPA identified six subgroups with markedly different patient outcomes that demonstrated a significant correlation with breast cancer subtypes identified by transcriptional profiling. CONCLUSION: Thus, the robustness of RPPA and stability of the functional proteomic "fingerprint" facilitate the study of the functional proteome in non-microdissected breast tumors.

  11. Secondary prevention of cervical cancer through the development and implementation of a system to optimize diagnostic and therapeutic and rehabilitation measures in the background and precancerous cervical diseases

    Directory of Open Access Journals (Sweden)

    F. F. Badretdinova

    2012-01-01

    Full Text Available The results of a comprehensive evaluation and treatment of background and pre-cancerous cervical cancer of women were studied (n = 1022. There is the complex assessment of social and obstetric gynecological risk factors for cervical intraepithelial neoplasia and cervical cancer. A system for optimizing diagnostic, therapeutic, preventive and rehabilitative measures, taking into account the differentiated approach to the choice of treatment, follow-up in the near and long-term postoperative period. An individual approach to the selection of organ presentation or radical treatment using new technologies of surgical treatment are identified. Application of the developed system enabled a statistically significantly improve the results of treatment of background and precancerous cervical disease.

  12. Using community engagement to inform and implement a community-randomized controlled trial in the Anishinaabek Cervical Cancer Screening Study (ACCSS

    Directory of Open Access Journals (Sweden)

    Brianne eWood

    2014-02-01

    Full Text Available Social, political, and economic factors are directly and indirectly associated with the quality and distribution of health resources across Canada. First Nations (FN women in particular endure a disproportionate burden of ill health in contrast to the mainstream population. The complex relationship of health, social, and historical determinants are inherent to increased cervical cancer in FN women. This can be traced back to the colonial oppression suffered by Canadian FN and the social inequalities they have since faced. Screening - the Papinacolaou (Pap test – and early immunization have rendered cervical cancer almost entirely preventable but despite these options, FN women endure notably higher rates of diagnosis and mortality due to cervical cancer. The Anishinaabek Cervical Cancer Screening Study (ACCSS is a participatory action research project investigating the factors underlying the cervical cancer burden in FN women. ACCSS is a collaboration with 11 FN communities in Northwest Ontario, Canada and a multidisciplinary research team from across Canada with expertise in cancer biology, epidemiology, medical anthropology, public health, virology, women’s health, and pathology. Interviews with healthcare providers and community members revealed that prior to any formal data collection education must be offered. Consequently, an educational component was integrated into the existing quantitative design of the study: a two-armed, community-randomized trial that compares the uptake of two different cervical screening modalities. In ACCSS, the Research Team integrates community engagement and the flexible nature of participatory research with the scientific rigor of a randomized controlled trial. ACCSS findings will inform culturally appropriate screening strategies, aiming to reduce the disproportionate burden of cervical disease in concert with priorities of the partner FN communities.

  13. Addition to our technical center arco therapy volume (VMAT) in the treatment of prostate cancer; Incorporacion en nuestro centro de la tecnica de arcoterapia volumetrica (VMAT) en el tratamiento de cancer de prostata

    Energy Technology Data Exchange (ETDEWEB)

    Mateos, J. C.; Cabrera, P.; Luis, J.; Perucha, M.; Sanchez, G.; Herrador, M.; Ortiz, M. J.

    2011-07-01

    The purpose of this paper is the description of the incorporation of the treatment technique radiotherapy Arcoterapia Volumetric (VMAT) in our hospital, patients with prostate cancer risk. The technological complexity of this type, which vary simultaneously the influence of radiation, the blades of the multileaf collimator (MLC) and the angular velocity of the accelerator head, determine a major challenge in designing the plan and verify the feasibility treatments.

  14. Technical Documentation in Traffic Technology

    OpenAIRE

    Čurepić, Danko; Toš, Zdravko

    2009-01-01

    The requirements for the prompt usage of traffic infrastructure capacities define the technological frames which ensure updated maintenance and development of new traffic infrastructure capacities by implementing graphical and computer systems. Technical documentation (TD) based on the technology of geographic information systems (GIS) allows fast analysis of graphical and alphanumerical data with the aim of identifying spatial relations among various cartographic elements. The paper analyses...

  15. Pilot implementation

    DEFF Research Database (Denmark)

    Hertzum, Morten; Bansler, Jørgen P.; Havn, Erling C.;

    2012-01-01

    A recurrent problem in information-systems development (ISD) is that many design shortcomings are not detected during development, but first after the system has been delivered and implemented in its intended environment. Pilot implementations appear to promise a way to extend prototyping from...... the laboratory to the field, thereby allowing users to experience a system design under realistic conditions and developers to get feedback from realistic use while the design is still malleable. We characterize pilot implementation, contrast it with prototyping, propose a five-element model of pilot...... implementation, and provide three empirical illustrations of our model. We conclude that pilot implementation has much merit as an ISD technique when system performance is contingent on context. But we also warn developers that, despite their seductive conceptual simplicity, pilot implementations can...

  16. M-Learning System Implementation and Features

    OpenAIRE

    Hrad, Jaromír; ZEMAN, Tomáš; Nevosad, Marek

    2015-01-01

    The article offers an insight into specific features of mobile e-learning (m-learning) in terms of technical implementation, available platforms and their related problems, and evaluates the practical experience. It also summarizes reasons for introduction of mobile learning and analyzes available options for its technical implementation. Specific example is used to demonstrate practical use of m-learning courses – learning of English language for a defined group of recipients within an inter...

  17. Implementation of Constant Dose Rate and Constant Angular Spacing Intensity-modulated Arc Therapy for Cervical Cancer by Using a Conventional Linear Accelerator

    Directory of Open Access Journals (Sweden)

    Ruo-Hui Zhang

    2016-01-01

    Conclusions: Patients with cervical cancer treated with CDR-CAS-IMAT using Varian Clinical 23EX can get equivalent or superior dose distribution compared to those treated with IMRT. CDR-CAS-IMAT has a less treatment time and MU, which can reduce the uncertainty factor and patient discomfort in treatment.

  18. Preliminary experience on the implementation of computed tomography (CT)-based image guided brachytherapy (IGBT) of cervical cancer using high-dose-rate (HDR) Cobalt-60 source in University of Malaya Medical Centre (UMMC)

    Science.gov (United States)

    Jamalludin, Z.; Min, U. N.; Ishak, W. Z. Wan; Malik, R. Abdul

    2016-03-01

    This study presents our preliminary work of the computed tomography (CT) image guided brachytherapy (IGBT) implementation on cervical cancer patients. We developed a protocol in which patients undergo two Magnetic Resonance Imaging (MRI) examinations; a) prior to external beam radiotherapy (EBRT) and b) prior to intra-cavitary brachytherapy for tumour identification and delineation during IGBT planning and dosimetry. For each fraction, patients were simulated using CT simulator and images were transferred to the treatment planning system. The HR-CTV, IR-CTV, bladder and rectum were delineated on CT-based contouring for cervical cancer. Plans were optimised to achieve HR-CTV and IR-CTV dose (D90) of total EQD2 80Gy and 60Gy respectively, while limiting the minimum dose to the most irradiated 2cm3 volume (D2cc) of bladder and rectum to total EQD2 90Gy and 75Gy respectively. Data from seven insertions were analysed by comparing the volume-based with traditional point- based doses. Based on our data, there were differences between volume and point doses of HR- CTV, bladder and rectum organs. As the number of patients having the CT-based IGBT increases from day to day in our centre, it is expected that the treatment and dosimetry accuracy will be improved with the implementation.

  19. Cancer and birth defects surveillance system for communities around the Savannah River Site: Phase 2 -- Birth defects. Technical progress report, year 01

    Energy Technology Data Exchange (ETDEWEB)

    Dunbar, J.B.

    1995-10-01

    The Savannah River Region Health Information System Birth Defects Registry (SRRHIS-BDR) began on September 30, 1994. As with the SRRHIS Cancer Registry, surveillance of the 12 Georgia counties was subcontracted to Emory University School of Public Health. Collaborative efforts between the Medical University of South Carolina (MUSC) and Emory University staffs have been characterized by warm relationships and commitment to developing a state of the art registry. As a result of early planning efforts, the authors were able to actually activate the data collection. As of the end of September 1995, partial data from the 1994 birth cohort and up-to-date data for the 1995 birth cohort had been collected on the South Carolina side. The Georgia Staff started later and have not yet caught up to the 1994 level. South Carolina was able to start earlier because they were fortunate to quickly recruit an abstractor. Also, by the end of the first year, an innovative automated data entry system for laptop computers was developed by the computer staff to facilitate and improve data collection.

  20. Cancer and birth defects surveillance system for communities around the Savannah River Site: Phase 2 -- Birth defects. Technical progress report, year 01

    International Nuclear Information System (INIS)

    The Savannah River Region Health Information System Birth Defects Registry (SRRHIS-BDR) began on September 30, 1994. As with the SRRHIS Cancer Registry, surveillance of the 12 Georgia counties was subcontracted to Emory University School of Public Health. Collaborative efforts between the Medical University of South Carolina (MUSC) and Emory University staffs have been characterized by warm relationships and commitment to developing a state of the art registry. As a result of early planning efforts, the authors were able to actually activate the data collection. As of the end of September 1995, partial data from the 1994 birth cohort and up-to-date data for the 1995 birth cohort had been collected on the South Carolina side. The Georgia Staff started later and have not yet caught up to the 1994 level. South Carolina was able to start earlier because they were fortunate to quickly recruit an abstractor. Also, by the end of the first year, an innovative automated data entry system for laptop computers was developed by the computer staff to facilitate and improve data collection

  1. Standardized implementation and evaluation of conventional open radical resection for distal gastric cancer%经腹远端胃癌根治术规范化实施及评价

    Institute of Scientific and Technical Information of China (English)

    戴冬秋; 张春东

    2014-01-01

    The incidence of gastric cancer in China is high and most patients are diagnosed at advanced stage. Surgery is one of the key therapies for patients with advanced gastric cancer. Gastrectomy with D2 lymphadenectomy is the standard operation for advanced gastric cancer. However, there are still many problems in the process of standardized implementation. Surgeon should master the standardized implementation, significance of preoperative staging, preoperative and particularly intraoperative management of surgical indications, standardized sequence of operation, method of lymph node dissection, determination of gastrectomy, operation of tumor-free technique, treatment and prevention for intraoperative damage or postoperatively serious complications.%我国胃癌发病率高,多数病人就诊时已处于进展期,手术是治疗进展期胃癌的重要手段之一。胃癌D2根治术是进展期胃癌的标准术式,而在其规范化实施过程中仍存在诸多问题。外科医生应掌握经腹远端胃癌根治术的规范化实施要点,术前分期的意义,术前、尤其术中合理确定手术适应证的要点,规范化的手术操作顺序,淋巴结清扫方法,胃切除范围判定,无瘤技术操作及术中损伤及术后常见严重并发症防治等问题。

  2. Guiding the Grey: The Implementation and Evaluation of a Journal Club amongst a Librarian and Clinical Practice Guideline Developers – A Cancer Care Case Study

    OpenAIRE

    Vaska, Marcus; Kostaras, Xanthoula (Alberta Health Services, Canada); MacLeod, Emily (Alberta Health Services, Canada); Meek, Elysa (Alberta Health Services, Canada); Shea-Budgell, Melissa (Alberta Health Services, Canada); Watson, Laurissa (Alberta Health Services, Canada); GreyNet, Grey Literature Network Service

    2014-01-01

    Introduction/Goal: As a research-intensive facility located within a cancer care environment, library services provided at the Holy Cross Site closely adhere to an embedded librarian mandate, one where the librarian “actively engages in activities, possesses extensive knowledge of the researcher’s work, and offers assistance above and beyond common library service expectations” (Strain, 2011). The Guideline Utilization Resource Unit (GURU) is composed of knowledge management specialists...

  3. Implementation of a Theory-based, Non-clinical Patient Navigator Program to Address Barriers in an Urban Cancer Center Setting.

    Science.gov (United States)

    Fleisher, Linda; Miller, Suzanne M; Crookes, Danielle; Kandadai, Venk; Wen, Kuang Yi; Slamon, Rachel E; Chaivous, Jeanne

    2012-06-01

    Cancer patients face a myriad of psychosocial and practical issues. Especially challenging is the time from an initial diagnosis to the onset of treatment and patient navigation services are important to guide patients, especially underserved populations, through this maze of uncertainty. Here we report on the Pennsylvania Patient Navigator Demonstration Project (PaPND) designed to evaluate the acceptability, feasibility, and impact of a culturally and linguistically appropriate non-clinical navigator program. The development of the project, based on behavioral theory and community-based participatory research principles, is described. Forty-four cancer patients from diverse backgrounds participated, which included a baseline assessment, navigation services, and a four week and twelve week follow-up assessment. On average, participants experienced 1.8 barriers with transportation and insurance issues the most common barriers. The majority (56%) of the barriers required more than an hour of the navigator's time to address, with insurance, transportation and caregiver/support issues requiring the most time. Overall patients were fairly satisfied with the navigation services. The findings showed improvement patient's stress-related thoughts, cognition (understanding of their disease), expectancies and beliefs or values/goals, as well as self-efficacy of managing cancer related issues from the baseline to follow-up assessments. The evaluation results suggest that providing and connecting cancer patients to appropriate information to improve their understanding of their diagnosis and recommended treatments needs to be addressed, and where the integration of non-clinical and clinical navigation is essential. In addition, more attention to the assessment of psychosocial issues, such as the patients' emotional worries, and more comprehensive training in these areas would enhance navigation programs.

  4. Consequences of anorectal cancer atlas implementation in the cooperative group setting: Radiobiologic analysis of a prospective randomized in silico target delineation study

    International Nuclear Information System (INIS)

    Purpose: The aim of this study is to ascertain the subsequent radiobiological impact of using a consensus guideline target volume delineation atlas. Materials and methods: Using a representative case and target volume delineation instructions derived from a proposed IMRT rectal cancer clinical trial, gross tumor volume (GTV) and clinical/planning target volumes (CTV/PTV) were contoured by 13 physician observers (Phase 1). The observers were then randomly assigned to follow (atlas) or not-follow (control) a consensus guideline/atlas for anorectal cancers, and instructed to re-contour the same case (Phase 2). Results: The atlas group was found to have increased tumor control probability (TCP) after the atlas intervention for both the CTV (p < 0.0001) and PTV1 (p = 0.0011) with decreasing normal tissue complication probability (NTCP) for small intestine, while the control group did not. Additionally, the atlas group had reduced variance in TCP for all target volumes and reduced variance in NTCP for the bowel. In Phase 2, the atlas group had increased TCP relative to the control for CTV (p = 0.03). Conclusions: Visual atlas and consensus treatment guideline usage in the development of rectal cancer IMRT treatment plans reduced the inter-observer radiobiological variation, with clinically relevant TCP alteration for CTV and PTV volumes

  5. [On the implementation by Rospotrebnadzor (Federal service for the oversight of consumer protection and welfare) common principles and rules of technical regulation within the agreement of the Customs Union].

    Science.gov (United States)

    Onishchenko, G G

    2013-01-01

    In accordance with the Agreement of the Customs Union on sanitary measures between the Government of the Russian Federation, the Republic of Belarus and the Republic of Kazakhstan in the customs territory of the Customs Union the Uniform sanitary and epidemiological and hygienic requirements for goods subject to sanitary-epidemiological control are applied. Common sanitary requirements are binding for executive authorities of the Member States of the Customs union, local authorities, legal persons, whatever legalform, individual entrepreneurs, individuals. Currently, out of 47 planned to take priority technical regulations of the Customs Union 31 regulation, including the safety of railway rolling stock, production of perfumery and cosmetics, toys and products for children and teenagers, food products, grain, and other furniture products was adopted. PMID:24340592

  6. Review manual for aging management technical evaluation

    International Nuclear Information System (INIS)

    'Review Manual for Aging Management Technical Evaluation' defines the procedure for the Japan Nuclear Energy Safety Organization (JNES) to review technical adequacy of applicant's aging management technical evaluation report on aging degradation of nuclear power generation equipment which describes technical bases of long-term maintenance programs in applicant's operational safety program. JNES has prepared review manuals for aging management technical evaluation consisted of review manuals for six major degradation mechanisms (low-cycle fatigue, neutron irradiation embrittlement, irradiation assisted stress corrosion cracking, thermal aging embrittlement of cast austenitic stainless steel, insulation degradation of electric and instrumentation equipment, reduced strength and shielding performance of concrete), review manual for seismic safety and general review manual which correlates these manuals and conducted reviews for aging management technical evaluation. However, due to the enforcement of revised Act on the Regulation of Nuclear Source Material, Nuclear Fuel Material and Reactors on July 8, 2013 and the revision of safety standards related to aging management technical evaluation, the Nuclear Regulation Authority (NRA) revised aging management implementation guideline for nuclear power generation equipment and the secretariat of NRA revised the review guideline for aging management technical evaluation. As a result of these revisions, JNES revised review manuals for aging management technical evaluation and integrated them in this review manual. (author)

  7. Relational Study of Technical Education in Scotland and Nigeria for Sustainable Skill Development

    Science.gov (United States)

    Umunadi, E. Kennedy

    2014-01-01

    This paper was designed to look at technical education curriculum and mode of implementation in Scotland in order to adopt the advantageous attributes of the Scottish technical education in Nigeria. The paper x-rayed the staff perceptions of technical education and its roles in Scotland; history of technical education before the advent of British…

  8. 银行业信息科技风险动态监测平台的研究与实践*%Implementation of Dynamic Monitoring Platform for Scientific and Technical Risks of Banking Industry

    Institute of Scientific and Technical Information of China (English)

    刘剑; 葛鋆

    2015-01-01

    This paper describes the security threats and the existing risks faced by the bank. From the perspective of banking man-agement, scientific and technical risks of banking Information are reviewed and an idea to construct unified dynamic monitoring and supervision platform built by supervision organization is proposed. In consideration of some factors like monitoring, evaluation, event management etc., the platform is composed of seven parts including dynamic monitoring center, massive data center, risk assessment and modeling center, data extraction mining center, security incident forensic center, expert knowledge base and secure service net-work. Based on the real-time scientific and technical risks supervision framework, the platform can effectively improve the non-spot supervision quality of bank supervision departments.%本文介绍了银行面临的安全威胁和存在的风险,从银行监管机构的角度审视银行信息科技风险监管工作,提出由监管机构建设统一的动态监测与监管平台的构想,并从监测、评估、事件管理等纬度,把平台分为动态监测中心、海量数据中心、风险评估建模中心、数据抽取挖掘中心、安全事件取证中心、专家知识库和安全服务网络七个部分。基于该平台银行监管机构可以开展实时的银行信息科技风险监管,能极大的提高监管机构非现场监管的质量。

  9. 混凝土轨枕养护现状分析与技术改造实施方案%Analyses on Concrete Sleeper-Curing Status Quo and Technical Reconstruction Implementation Scheme

    Institute of Scientific and Technical Information of China (English)

    孙旭亮

    2012-01-01

    According to the standards of track concrete sleeper-curing specified in high-speed railway technical conditions, this paper briefly analyzes the importance of concrete curing. The paper, in combination with the problems of low temperature steam curing, also analyzes the reason why the existing curing pool is difficult to meet the technical requirements so as to renovate the existing curing pool. Finally, through sleeper static-load crack strength test, natural curing test and moisture curing test after sleepers being taken out from the pool before pool reconstruction and by way of test data analysis, this paper works out the reasonable curing system and puts forward the new method of sleeper curing.%依据高速铁路混凝土轨枕技术条件中规定的养护标准,浅析混凝土养护的重要性;结合执行低温蒸汽养护时遇到的问题,分析原有养护池难以达到技术要求的原因,对养护池进行改造;通过养护池改造前轨枕静载抗裂强度试验、养护池内自然养护试验、轨枕出池后保湿养护试验和试验数据分析,制定出合理的养护制度,提出了轨枕养护的新方法.

  10. System Design and Implementation for Cervical Cancer and Breast Cancer Screening%宫颈癌与乳腺癌筛查信息系统设计与实现

    Institute of Scientific and Technical Information of China (English)

    王朝; 武明辉; 韩历丽; 张娣

    2014-01-01

    Objective The application of modern information technology will be expected to improve the quality and management of cervical cancer, breast cancer screening in Beijing. Method Improved and reconstructed sub-system of cervical cancer and breast cancer screening based on the second phase development of the Beijing MCH information system. Results The screening information system is able to digitize the whole process of cervical cancer and breast cancer screening, including basic information collection, medical recording of screening and suspicious patients diagnosis, treatments and follow-ups which enables information sharing, management improving and data availability as well. Conclusion It is necessary to apply information technology to cervical cancer and breast cancer screening. The information system plays an important role to optimize the work flow, enhance the MCH information, and improve its efficiency and quality.%目的将现代信息技术引入宫颈癌、乳腺癌筛查工作,以提高两癌筛查工作的服务和管理水平。方法基于北京市妇幼保健信息系统二期开发建设,对两癌筛查子系统进行升级改造。结果两癌筛查信息系统可以实现从个人基本信息采集、筛查及诊断结果录入,到可疑病例确诊、治疗、随访等全过程的信息化,实现信息共享,提高了工作效率,提升了两癌筛查系统管理水平,为各级管理者提供及时有效的信息数据。结论将信息技术引入两癌筛查工作领域有其必要性,两癌筛查信息管理系统可以优化工作流程,提升妇幼保健信息管理层次,提高工作效率和质量。

  11. Technical approach to groundwater restoration

    International Nuclear Information System (INIS)

    The Technical Approach to Groundwater Restoration (TAGR) provides general technical guidance to implement the groundwater restoration phase of the Uranium Mill Tailings Remedial Action (UMTRA) Project. The TAGR includes a brief overview of the surface remediation and groundwater restoration phases of the UMTRA Project and describes the regulatory requirements, the National Environmental Policy Act (NEPA) process, and regulatory compliance. A section on program strategy discusses program optimization, the role of risk assessment, the observational approach, strategies for meeting groundwater cleanup standards, and remedial action decision-making. A section on data requirements for groundwater restoration evaluates the data quality objectives (DQO) and minimum data required to implement the options and comply with the standards. A section on sits implementation explores the development of a conceptual site model, approaches to site characterization, development of remedial action alternatives, selection of the groundwater restoration method, and remedial design and implementation in the context of site-specific documentation in the site observational work plan (SOWP) and the remedial action plan (RAP). Finally, the TAGR elaborates on groundwater monitoring necessary to evaluate compliance with the groundwater cleanup standards and protection of human health and the environment, and outlines licensing procedures

  12. Strategy of technical innovation

    International Nuclear Information System (INIS)

    This book deals with policy of scientific technique and technical innovation such as research for development and types of technical innovation, historical development and process of technical innovation, economic growth, technology change and investment for research and development, structure and form of technical transfer with the meaning process, from, structure and theory, economic growth and investment of research and development with experiential analysis and case study on strategy of technical innovation in electron and fine chemical industry.

  13. Discussion on Foreseeing the Enterprises Technical Standards

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Under the condition of market economy, the need for products to be characteristic is getting more and more outstanding, and the product market will be transferred gradually from the seller's market to the buyer's. After the issue and implementation of the enterprises technical standards, there will be a stable period. The matter of how to guarantee the products to satisfy the need of the market within this period requires that the enterprise must take the foreseeing of standards into account when developing technical standards, so as to ensure the products to be of persistent competitive power in the market. Here are some things that can show the foreseeing of enterprises technical standards.

  14. Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Helen Cunning

    2012-05-08

    Hackensack University Medical Center's major initiative to create a cleaner healthier and safer environment for patients, employees and the community served by the medical center is built on its commitment to protect the environment and conserve precious energy resources. Since 2004 the Medical Center launched a long term campaign to temper the negative environmental impact of proposed and existing new construction at the medical center and to improve campus wide overall energy efficiency. The plan was to begin by implementing a number of innovative and eco-friendly enhancements to the Gabrellian Women's and Children's Pavilion, in construction at the time, which would lead to Certification by the US Green Building Councils Leadership & Environmental Design (LEED) program. In addition the medical center would evaluate the feasibility of implementing a photovoltaic system in the new construction (in development and planned) to provide clean pollution free electricity. The steps taken to achieve this included conducting a feasibility study complete with architectural and engineering assessments to determine the potential for implementation of a photovoltaic system on the campus and also to conduct an energy survey that would focus on determining specific opportunities and upgrades that would lead to a healthier energy efficient interior environment at the medical center. The studies conducted by the medical center to determine the viability of installing a photovoltaic system identified two key issues that factored into leaderships decision not to implement the solar powered system. These factors were related to the advanced phase of construction of the women's and children's pavilion and the financial considerations to redesign and implement in the ambulatory cancer center. The medical center, in spite of their inability to proceed with the solar aspect of the project upheld their commitment to create a healthier environment for the patients

  15. Improved overall survival after implementation of targeted therapy for patients with metastatic renal cell carcinoma: Results from the Danish Renal Cancer Group (DARENCA) study-2

    DEFF Research Database (Denmark)

    Sørensen, Anne V.; Donskov, Frede; Hermann, Gregers G.;

    2014-01-01

    AbstractAim To evaluate the implementation of targeted therapy on overall survival (OS) in a complete national cohort of patients with metastatic renal cell carcinoma (mRCC). Methods All Danish patients with mRCC referred for first line treatment with immunotherapy, TKIs or mTOR-inhibitors between...... received first line treatment. From 2006 to 2010 we observed a significant increase in the number of referred patients; a significant increase in treated patients (64% versus 75%, P = 0.0188); a significant increase in first line targeted therapy (22% versus 75%, P ....06–0.60; P = 0.0051) were significantly associated with longer OS. Conclusion This retrospective study documents that the implementation of targeted therapy has resulted in significantly improved treatment rates and overall survival in a complete national cohort of treated mRCC patients....

  16. 化工职业技术教学应积极实施应用性创新%Chemical Vocational and Technical Teaching Should Implement Applied Innovation Actively

    Institute of Scientific and Technical Information of China (English)

    沙乖凤

    2011-01-01

    面对人才资源市场优化配置和经济结构调整的实际,着眼发展,使化工职业技术教学走出传统教学体制,用生产人才,销售人才的方式理念,面向市场,将化工教学扩展到应用化工技术发展的前沿,预测储备师资,灵活开设专业,并采用研究式学习方式,注重应用实践,兼收前沿发展信息,培育适合市场需求的合格化工技术人才.%Faced with the reality of optimal allocation of human resources market and economic structural adjustment, we should focus on development so that chemical vocational and technical teaching should break away from traditional system, and using the concept of production personnel, sales personnel, facing market will make chemical teaching extend to forefront of applied chemical technological development, forecast and reserve teachers, set up specialty flexibly and use research-based learning approach, focus on practical applications, integrated development of cutting-edge information to cultivate qualified chemical technicians who are suitable for the market demand.

  17. Proceedings of the IEA-technical workshop on the test cell system for an international fusion materials irradiation facility, Karlsruhe, Germany, July 3-6, 1995. IEA-implementing agreement for a programme of research and development on fusion materials

    International Nuclear Information System (INIS)

    After a Conceptual Design Activity (CDA) study on an International Fusion Material Irradiation Facility (IFMIF) has been launched under the auspices of the IEA, working groups and relevant tasks have been defined and agreed in an IEA-workshop that was held September 26-29 1994 at Karlsruhe. For the Test Cell System 11 tasks were identified which can be grouped into the three major fields neutronics, test matrix/users and test cell engineering. In order to discuss recently achieved results and to coordinate necessary activities for an effective design integration, a technical workshop on the Test Cell System was initiated. This workshop was organized on July 3-6 1995 by the Institute for Materials Research I at the Forschungszentrum Karlsruhe and attended by 20 specialists working in the fields neutronics, fusion materials R and D and test cell engineering in the European Union, Japan, and the United States of America. The presentations and discussions during this workshop have shown together with the elaborated lists of action items, that has been achieved in all three fields, and that from the future IFMIF experimental program for a number of materials a database covering widerspread loading conditions up to DEMO-reactor relevant end-of-life damage levels can be expected. (orig.)

  18. Reduction of Invasive Fungal Infections Among Cancer Patients With Chemotherapy-Induced Neutropenia After Protective Environment Implementation May Save Costs in a Developing Country: A Quasi-Experimental Study

    Directory of Open Access Journals (Sweden)

    Stoll

    2015-11-01

    Full Text Available Background Invasive fungal infections (IFI represent a serious threat for severely immunocompromised patients. Infection control interventions, including protective environment (PE implementation, are essential to reduce IFI incidence, mortality and burden of hospitalization, among high-risk patients. Information about the impact of these strategies in cancer patients with chemotherapy-induced neutropenia (CIN, in developing countries, is insufficient. Objectives To assess the impact of PE implementation on IFI incidence, consumption and cost of antifungal treatment, in a general, tertiary teaching hospital, in Southern Brazil. Patients and Methods We conducted a quasi-experimental study to evaluate an institutional intervention, in a hospital ward, for patients with CIN, which consisted in renovation of the ward and measures involving air-quality technologies installation, the main one being high efficiency particulate air (HEPA filters. Simultaneously, infection control routines were implemented. Neutropenic patients, admitted to any other hospital ward, prior to the renovation, were included in the historical control group. The IFI incidence was defined, according to the criteria proposed by the European Organization for Research and Treatment of Cancer. Direct costs of antifungal drugs were recorded, for all neutropenic patients. Results A total of 190 and 181 hospital admissions were included in the intervention and control groups, respectively. Total IFI incidence was reduced in the PE group (7.4% vs. 18.2%; P = 0.002 and the same was observed when considering only proven and probable IFI (1.6% vs. 8.3%; P = 0.003. This benefit persisted even after adjusting for antifungal prophylaxis (OR = 0.17; 95% CI = 0.05 ‒ 0.60. We observed a decreasing trend in molds and yeasts IFI incidence, in the intervention group. Although the final cost of antifungal agents was lower, after intervention (78347.37 USD vs. 154176.60 USD, the median cost per

  19. Does obesity hinder radiotherapy in endometrial cancer patients? The implementation of new techniques in adjuvant radiotherapy – focus on obese patients

    Directory of Open Access Journals (Sweden)

    Małgorzata Moszyńska-Zielińska

    2014-05-01

    Full Text Available The increasing incidence of obesity in Poland and its relation to endometrioid endometrial cancer (EEC is resulting in the increasing necessity of treating obese women. Treatment of an overweight patient with EEC may impede not only the surgical procedures but also radiotherapy, especially external beam radiotherapy (EBRT. The problems arise both during treatment planning and when delivering each fraction due to the difficulty of positioning such a patient – it implies the danger of underdosing targets and overdosing organs at risk. Willingness to use dynamic techniques in radiation oncology has increased for patients with EEC, even those who are obese. During EBRT careful daily verification is necessary for both safety and treatment accuracy. The most accurate method of verification is cone beam computed tomography (CBCT with soft tissue assessment, although it is time consuming and often requires a radiation oncologist. In order to improve the quality of such treatment, the authors present the practical aspects of planning and treatment itself by means of dynamic techniques in EBRT. The authors indicate the advantages and disadvantages of different types of on-board imaging (OBI verification images. Considering the scanty amount of literature in this field, it is necessary to conduct further research in order to highlight proper planning and treatment of obese endometrial cancer patients. The review of the literature shows that all centres that wish to use EBRT for gynaecological tumours should develop their own protocols on qualification, planning the treatment and methods of verifying the patients’ positioning.

  20. 辽宁省农村妇女乳腺癌检查项目实施结果与分析%Implementation Results and Analysis of Women Breast Cancer Screening Project in Rural Area,Liaoning Province

    Institute of Scientific and Technical Information of China (English)

    肖伟; 孙丽华

    2013-01-01

    [Purpose] To review the project of women breast cancer screening in rural area,Liaoning Province and to investigate the implementation effect and possible problems.[Methods] The breast cancer screening data of 35 ~ 59 years old women from 2009 to 2011 in 7 rural areas of Liaoning province were analyzed.[Results] There were 42064 women enrolled in this project,23 breast cancer cases were diagnosed (including 14 early cases),and 2 cases with pre-cancerous.Early diagnose rate was 60.87% ;treatment rate,100%.[Conclusion] Breast cancer screening project for rural area women is feasible with remarkable social benefits.The intensity of training should carried out extensively.Experts' guidance,especially in the early days of the project,could rapidly enhance to diagnostic level to primary care physicians.%[目的]总结辽宁省农村妇女乳腺癌检查项目工作,探讨实施效果和问题.[方法]分析2009~2011年辽宁省7个地区35~59岁农村户籍妇女乳腺癌检查资料.[结果]2009~2011年共检查42 064名农村妇女,检出乳腺癌23例(其中早期癌14例),癌前病变2例,早诊率为60.87%.治疗率100%.[结论]在农村开展妇女乳腺癌检查项目可行,社会效益突出;应拓展宣传、培训的力度和形式.专家现场操作指导,特别是项目开展初期对基层专业技术人员传、帮、带培训方式,是快速提升基层医师诊断技能有效地途径.

  1. Analysis on Problems Should be Valued in EIA after the Implementation of Technical Guidelines for Noise Impact Assessment( H J2.4 -2009)%浅析“环境影响评价技术导则声环境”(HJ2.4—2009)实施后环评中应重视的问题

    Institute of Scientific and Technical Information of China (English)

    崔小爱

    2011-01-01

    从总则及编写要求、评价等级、声环境现状调查及评价、声环境影响预测几个方面分析了《环境影响评价技术导则声环境》95版和09版的区别,在此基础上,以江苏省内公路噪声环境影响评价为例,浅析了导则09版实施后在环评工作中应重视的一些问题,供学习与探讨。%The differences between version 95 and version 09 of Technical Guidelines for Noise Impact Assessment are analyzed from the aspects of general rules and compiling requests, evaluating grade, ecological environmental quality investigation and assessment, ecological environmental impact forecast. Based on these factors, some problems which should be valued after the implementation of Technical Guidelines for Noise Impact Assessment ( H J2.4 - 2009) in environmental impact assessment (EIA) are analyzed by taking the EIA of expressways in Jiangsu Province as example so as to provide reference of learning and discussion.

  2. Technical assistance contractor Management Plan

    International Nuclear Information System (INIS)

    The Technical Assistance Contractor (TAC) for the Uranium Mill Tailings Remedial Action (UMTRA) Project comprises Jacobs Engineering Group Inc. (JEG) and its major teaming partners [Roy F. Weston, Inc. (RFW), Sergent, Hauskins ampersand Beckwith Agra, Inc. (SHB Agra), and Geraghty ampersand Miller, Inc. (G ampersand M)]. The first three companies have worked together effectively on the UMTRA Project for more than 10 years. With the initiation of the UMTRA Groundwater Project in April 1991, a need arose to increase the TAC's groundwater technical breadth and depth, so G ampersand M was brought in to augment the team's capabilities. The TAC contract's scope is to provide technical, analytical, environmental, engineering, design, inspection, and management support services to the US Department of Energy (DOE) for both surface and groundwater projects. The TAC team continues to support the DOE in completing surface remedial actions and initiating groundwater remediation work for start-up, characterization, design, construction oversight, and remedial operations. A key feature of the TAC's management approach is the extensive set of communication systems implemented for the UMTRA Project. These systems assist all functional disciplines in performing UMTRA Project tasks associated with management, technical support, administrative support, and financial/project controls

  3. Analysis over Critical Issues of Implementation or Non-implementation of the ABC Method in Romania

    Directory of Open Access Journals (Sweden)

    Sorinel Cãpusneanu

    2009-12-01

    Full Text Available This article analyses the critical issues regarding implementation or non-implementation of the Activity-Based Costing (ABC method in Romania. There are highlighted the specialists views in the field opinions and own point of view of the authors regarding informational, technical, behavioral, financial, managerial, property and competitive issues regarding implementation or non-implementation of the ABC method in Romania.

  4. Introductory statement at the Technical Assistance and Co-operation Committee of the Board of Governors. Vienna, 17 November 2003 [As delivered

    International Nuclear Information System (INIS)

    The IAEA's technical co-operation (TC) programme is focused on putting advanced science to work to meet the economic and social needs of developing countries. The TC planning process is briefly discussed, including recent evaluation results; highlighting of a number of key activities; and reviewing the current status of TC implementation and funding. The areas of activity include: The use of radiotherapy in cancer treatment; isotope hydrology; monitoring coastal and marine environment; plant breeding applications. Program implementation as well as program funding is discussed. The Agency is also working to reinforce technical co-operation among developing countries (TCDC), that is, the pooling of resources and expertise in areas of mutual benefit. It is stated that the TC programme has become a powerful tool for transferring nuclear science and technology to developing countries. But only if we work together in partnership can we ensure the success of the programme. I look forward to the continuation and further development of that partnership

  5. Automatic identification of organ/tissue regions in CT image data for the implementation of patient specific phantoms for treatment planning in cancer therapy

    Science.gov (United States)

    Sparks, Richard Blaine

    In vivo targeted radiotherapy has the potential to be an effective treatment for many types of cancer. Agents which show preferred uptake by cancerous tissue are labeled with radio-nuclides and administered to the patient. The preferred uptake by the cancerous tissue allows for the delivery of therapeutically effective radiation absorbed doses to tumors, while sparing normal tissue. Accurate absorbed dose estimation for targeted radiotherapy would be of great clinical value in a patient's treatment planning. One of the problems with calculating absorbed dose involves the use of geometric mathematical models of the human body for the simulation of the radiation transport. Since many patients differ markedly from these models, errors in the absorbed dose estimation procedure result from using these models. Patient specific models developed using individual patient's anatomical structure would greatly enhance the accuracy of dosimetry calculations. Patient specific anatomy data is available from CT or MRI images, but the very time consuming process of manual organ and tissue identification limits its practicality for routine clinical use. This study uses a statistical classifier to automatically identify organs and tissues from CT image data. In this study, image ``slices'' from thirty- five different subjects at approximately the same anatomical position are used to ``train'' the statistical classifier. Multi-dimensional probability distributions of image characteristics, such as location and intensity, are generated from the training images. Statistical classification rules are then used to identify organs and tissues in five previously unseen images. A variety of pre-processing and post-processing techniques are then employed to enhance the classification procedure. This study demonstrated the promise of statistical classifiers for solving segmentation problems involving human anatomy where there is an underlying pattern of structure. Despite the poor quality of

  6. Application of Ultrasound Elastography in the Implementation of Cervical Cancer%实施超声弹性成像技术在宫颈癌的应用研究

    Institute of Scientific and Technical Information of China (English)

    李敏

    2016-01-01

    目的:探究超声弹性成像技术在宫颈癌的应用。方法选取66例疑似宫颈癌患者作为研究对象,对其采用超声弹性成像技术进行诊断,之后将诊断结果与手术病理诊断结果相比较,探究差异性。结果采用超声弹性成像技术诊断结果与手术病理诊断结果相比,P >0.05,差异不具有统计学意义。结论实施超声弹性成像技术在宫颈癌的诊断中具有较高的临床诊断价值,可为临床治疗奠定诊断基础。%Objective Inquiry ultrasound elastography technique in cervical cancer. Methods Selected 66 cases of suspected cancer patients for the study,its use ultrasound elastography for diagnosis,after diagnosis compared with postoperative pathological diagnosis was to explore differences. Results Ultrasonic elastography diagnosis was not a big difference compared with the surgical pathology results,P > 0.05,the difference was not statistical y significant. Conclusion Implementation of ultrasound elastography has high diagnostic value in the diagnosis of cervical cancer,could provide a basis for clinical diagnosis,can be applied to promote.

  7. Design and Implementation of Interactive Electronic Technical Manual Based on VC and Flash%基于VC和Flash的交互式电子技术手册的设计与实现

    Institute of Scientific and Technical Information of China (English)

    何印洲; 马思乐; 王金晨; 尚伟

    2012-01-01

    Considering the difficulty in keeping and applying equipment manuals, the interactive electronic technical manual (IETM) design based on VC and Flash was discussed. IETM has functions like reading in order, index reading, drawings-navigation reading, spare parts tips, their fuzzy searching and management and changing their information,etc. The manual with ACCESS database, good expansibility and small space can be used on PCs with Office software. Application in a cigarette factory shows that this manual can facilitate workers, shorten maintenance cycle and benefit equipment management.%针对设备使用维修手册保管不便及查阅、使用繁琐等缺点,论述了基于VC和Flash的交互式电子技术手册(IETM)的设计.电子手册具有顺序阅读、索引阅读、图纸导航阅读、备件信息提示、备件信息修改、备件模糊搜索及备件综合管理等功能.该手册使用VC编程并借助Flash技术,兼顾了扩展性好和占用空间小的特点;数据库采用ACCESS数据库,使其在安装Office的电脑上即可使用.在某烟厂车间的应用表明:本手册方便了维护工人,缩减了维护周期,对设备管理具有良好的效果.

  8. Intensity-modulated arc therapy with simultaneous integrated boost in the treatment of primary irresectable cervical cancer. Treatment planning, quality control, and clinical implementation

    Energy Technology Data Exchange (ETDEWEB)

    Vandecasteele, Katrien; De Neve, Wilfried; De Gersem, Werner; Paelinck, Leen; Fonteyne, Valerie; De Wagter, Carlos; De Meerleer, Gert [Dept. of Radiotherapy, Ghent Univ. Hospital (Belgium); Delrue, Louke; Villeirs, Geert [Dept. of Radiology, Ghent Univ. Hospital (Belgium); Makar, Amin [Dept. of Gynecology, Ghent Univ. Hospital (Belgium)

    2009-12-15

    Purpose: to report on the planning procedure, quality control, and clinical implementation of intensity-modulated arc therapy (IMAT) delivering a simultaneous integrated boost (SIB) in patients with primary irresectable cervix carcinoma. Patients and methods: six patients underwent PET-CT (positron emission tomography-computed tomography) and MRI (magnetic resonance imaging) before treatment planning. Prescription (25 fractions) was (1) a median dose (D{sub 50}) of 62, 58 and 56 Gy to the primary tumor (GTVcervix), primary clinical target volume (CTVcervix) and its planning target volume (PTVcervix), respectively; (2) a D{sub 50} of 60 Gy to the PET-positive lymph nodes (GTVnodes); (3) a minimal dose (D{sub 98}) of 45 Gy to the planning target volume of the elective lymph nodes (PTVnodes). IMAT plans were generated using an anatomy-based exclusion tool with the aid of weight and leaf position optimization. The dosimetric delivery of IMAT was validated preclinically using radiochromic film dosimetry. Results: five to nine arcs were needed to create valid IMAT plans. Dose constraints on D{sub 50} were not met in two patients (both GTVcervix: 1 Gy and 3 Gy less). D{sub 98} for PTVnodes was not met in three patients (1 Gy each). Film dosimetry showed excellent gamma evaluation. There were no treatment interruptions. Conclusion: IMAT allows delivering an SIB to the macroscopic tumor without compromising the dose to the elective lymph nodes or the organs at risk. The clinical implementation is feasible. (orig.)

  9. Technical Report Writing Today

    DEFF Research Database (Denmark)

    Riordan, Daniel G.

    2014-01-01

    Section 1: Technical Communication Basics (8 chapters on tech com, audiences, tech com process, tech com style, researching, designing pages, using visual aids, describing). Section 2: Technical Communication Applications (7 chapters on sets of instructions, informal reports and email, developing...

  10. Technical training: places available

    CERN Multimedia

    2014-01-01

    If you would like more information on a course, or have any other inquiry/suggestions, please contact Technical.Training@cern.ch. Eva Stern and Elise Romero, Technical Training Administration (Tel: 74924)

  11. Technical training: places available

    CERN Multimedia

    2014-01-01

    If you would like more information on a course, or have any other inquiry/suggestions, please contact Technical.Training@cern.ch. Eva Stern and Marie Lahchimi, Technical Training Administration (Tel: 74924)

  12. Technical training: places available

    CERN Multimedia

    2013-01-01

    If you would like more information on a course, or for any other inquiry/suggestions, please contact Technical.Training@cern.ch. Eva Stern and Elise Romero, Technical Training Administration (Tel: 74924)

  13. Technical training: places available

    CERN Multimedia

    2013-01-01

    If you would like more information on a course, or for any other inquiry/suggestions, please contact Technical.Training@cern.ch. Eva Stern and Elise Romero, Technical Training Administration (Tél : 74924)  

  14. Technical training - places available

    CERN Multimedia

    2013-01-01

    If you would like more information on a course, or have any other inquiry/suggestions, please contact Technical.Training@cern.ch. Eva Stern and Elise Romero, Technical Training Administration (Tel: 74924)

  15. Implementation Politics

    DEFF Research Database (Denmark)

    Hegland, Troels Jacob; Raakjær, Jesper

    2008-01-01

    level are supplemented or even replaced by national priorities. The chapter concludes that in order to capture the domestic politics associated with CFP implementation in Denmark, it is important to understand the policy process as a synergistic interaction between dominant interests, policy alliances...

  16. Implementing TQM.

    Science.gov (United States)

    Bull, G; Maffetone, M A; Miller, S K

    1992-01-01

    Total quality management (TQM) is an organized, systematic approach to problem solving and continuous improvement. American corporations have found that TQM is an excellent way to improve competitiveness, lower operating costs, and improve productivity. Increasing numbers of laboratories are investigating the benefits of TQM. For this month's column, we asked our respondents: What steps has your laboratory taken to implement TQM?

  17. Solutions for cost effective assessment of software based instrumentation and control systems in nuclear power plants. Report prepared within the framework of the Technical Working Group on Nuclear Power Plant Control and Implementation

    International Nuclear Information System (INIS)

    The introduction of software based instrumentation and control (I and C) systems for use in nuclear power plants, mainly due to I and C modernization activities, has raised many issues of safety and economics. Many of these issues have been raised in the IAEA Technical Working Group on Nuclear Power Plant Control and Instrumentation (TWG-NPPCI) meetings and by other organizations, such as the OECD and the European Commission. One increasingly important issue is the need for engineering solutions to justify them for the cost effective assessment and deployment of software based I and C systems. To address this important issue, the IAEA put together the Co-ordinated Research Project (CRP) on Solutions for Cost Effective Assessments of Software based I and C Systems. The overall objective of the project is to facilitate the cost effective assessment of software based I and C systems in nuclear power plants. This is necessary to address obsolescence issues, to introduce new beneficial functionality, and to improve overall performance. The engineering solutions developed in this CRP will contribute to this overall objective. The objective of the CRP was reached through co-ordinated research and collected experience in the areas of project management; requirements specifications; use of software explicitly designed for nuclear applications, use of commercial off the shelf (COTS) products, generic pre-qualification of systems and components; safety and reliability enhancements; verification and validation; and licensing impact. This TECDOC is the result of the research and collected experience put together under this CRP. The CRP participants gave presentations on their work performed as part of this CRP at the various meetings of the group. The first meeting of the CRP was held in Vienna on 8-12 November 1999 in which the participants developed the objectives, scope, and outline of this report. The second meeting was held in Halden, Norway on 4-8 December 2000 and the

  18. Fiscal 1999 technical survey report. Model project implementation feasibility study in Malaysia on effective utilization of waste heat from paper sludge incineration; 1999 nendo Malaysia ni okeru seishi sludge nensho hainetsu yuko riyo model jigyo jisshi kanosei chosa hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    Efforts are under way to popularize practical energy conservation technologies through verification on real machines in target countries. Possibilities were studied that Malaysian paper making plants would adopt technologies of collecting heat from high-temperature exhaust gas from paper sludge incineration and of effectively utilizing the thus-collected heat. The Malaysian paper making industry produced 800-thousand tons or more in 1998, covering 72% of the total national demand. Heat recovery facilities may be installed in 15 plants. On-site surveys were made into their actual states, and then Genting Sanyen Industrial Paper Sdn. Bhd. was selected as the plant for the model project, and detailed model project feasibility studies were conducted. The studies covered the amount of wastes from paper making, their properties, treatment process, amounts of utilities to be used during system operation, land on which to build the facilities, and a plan for collecting invested funds. As the result, it was concluded in view of the magnitude of the expected fruit that the model project be implemented at this plant. (NEDO)

  19. Planning for environmental restoration of radioactively contaminated sites in central and eastern Europe. V. 3: Technologies for, and the implementation of, environmental restoration of contaminated sites. Proceedings of a workshop held within the technical co-operation project

    International Nuclear Information System (INIS)

    The radioactive contaminant materials resulting from diverse activities in relation to the nuclear fuel cycle, defence related operations, and various industries in addition to medical and research facilities represent perhaps the most severe and immense pollution left from a past era. The political changes in central and eastern Europe (CEE) not only brought some disclosure of the radioactively contaminated sites, but also resulted in a political condition in which this region became receptive to co-operation from a range of outside countries. The subjects of the first workshop held in Budapest, 4-8 October 1993, was the identification and characterization of radioactively contaminated sites in the region. The second part of the project and the second workshop (Piestany, Slovak Republic, 12-16 April 1994) involved planning and preparing the identified sites for restoration. This included items such as the restoration objectives, dose and environmental assessment, cost analysis, strategy and prioritization. Eventually, the third part of the project covered technologies for, and the implementation of, environmental restoration. The third and final workshop was held in Rez, Czech Republic, 12-16 December 1994. Refs, figs, tabs

  20. Population-level scale-up of cervical cancer prevention services in a low-resource setting: development, implementation, and evaluation of the cervical cancer prevention program in Zambia.

    Directory of Open Access Journals (Sweden)

    Groesbeck P Parham

    Full Text Available Very few efforts have been undertaken to scale-up low-cost approaches to cervical cancer prevention in low-resource countries.In a public sector cervical cancer prevention program in Zambia, nurses provided visual-inspection with acetic acid (VIA and cryotherapy in clinics co-housed with HIV/AIDS programs, and referred women with complex lesions for histopathologic evaluation. Low-cost technological adaptations were deployed for improving VIA detection, facilitating expert physician opinion, and ensuring quality assurance. Key process and outcome indicators were derived by analyzing electronic medical records to evaluate program expansion efforts.Between 2006-2013, screening services were expanded from 2 to 12 clinics in Lusaka, the most-populous province in Zambia, through which 102,942 women were screened. The majority (71.7% were in the target age-range of 25-49 years; 28% were HIV-positive. Out of 101,867 with evaluable data, 20,419 (20% were VIA positive, of whom 11,508 (56.4% were treated with cryotherapy, and 8,911 (43.6% were referred for histopathologic evaluation. Most women (87%, 86,301 of 98,961 evaluable received same-day services (including 5% undergoing same-visit cryotherapy and 82% screening VIA-negative. The proportion of women with cervical intraepithelial neoplasia grade 2 and worse (CIN2+ among those referred for histopathologic evaluation was 44.1% (1,735/3,938 with histopathology results. Detection rates for CIN2+ and invasive cervical cancer were 17 and 7 per 1,000 women screened, respectively. Women with HIV were more likely to screen positive, to be referred for histopathologic evaluation, and to have cervical precancer and cancer than HIV-negative women.We creatively disrupted the 'no screening' status quo prevailing in Zambia and addressed the heavy burden of cervical disease among previously unscreened women by establishing and scaling-up public-sector screening and treatment services at a population level. Key

  1. Implementation of a Novel Algorithm For Generating Synthetic CT Images From Magnetic Resonance Imaging Data Sets for Prostate Cancer Radiation Therapy

    International Nuclear Information System (INIS)

    Purpose: To describe and evaluate a method for generating synthetic computed tomography (synCT) images from magnetic resonance simulation (MR-SIM) data for accurate digitally reconstructed radiograph (DRR) generation and dose calculations in prostate cancer radiation therapy. Methods and Materials: A retrospective evaluation was performed in 9 prostate cancer patients who had undergone MR-SIM in addition to CT simulation (CT-SIM). MR-SIM data were used to generate synCT images by using a novel, voxel-based weighted summation approach. A subset of patients was used for weight optimization, and the number of patients to use during optimization was determined. Hounsfield unit (HU) differences between CT-SIM and synCT images were analyzed via mean absolute error (MAE). Original, CT-based treatment plans were mapped onto synCTs. DRRs were generated, and agreement between CT and synCT-generated DRRs was evaluated via Dice similarity coefficient (DSC). Dose was recalculated, and dose-volume metrics and gamma analysis were used to evaluate resulting treatment plans. Results: Full field-of-view synCT MAE across all patients was 74.3 ± 10.9 HU with differences from CTs of 2.0 ± 8.1 HU and 11.9 ± 46.7 HU for soft tissue structures (prostate, bladder, and rectum) and femoral bones, respectively. Calculated DSCs for anterior-posterior and lateral DRRs were 0.90 ± 0.04 and 0.92 ± 0.05, respectively. Differences in D99%, mean dose, and maximum dose to the clinical target volume from CT-SIM dose calculations were 0.75% ± 0.35%, 0.63% ± 0.34%, and 0.54% ± 0.33%, respectively, for synCT-generated plans. Gamma analysis (2%/2 mm dose difference/distance to agreement) revealed pass rates of 99.9% ± 0.1% (range, 99.7%-100%). Conclusion: Generated synCTs enabled accurate DRR generation and dose computation for prostate MR-only simulation. Dose recalculated on synCTs agreed well with original planning distributions. Further validation using a larger patient

  2. Implementation of a Novel Algorithm For Generating Synthetic CT Images From Magnetic Resonance Imaging Data Sets for Prostate Cancer Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Joshua, E-mail: jkim8@hfhs.org; Glide-Hurst, Carri; Doemer, Anthony; Wen, Ning; Movsas, Benjamin; Chetty, Indrin J.

    2015-01-01

    Purpose: To describe and evaluate a method for generating synthetic computed tomography (synCT) images from magnetic resonance simulation (MR-SIM) data for accurate digitally reconstructed radiograph (DRR) generation and dose calculations in prostate cancer radiation therapy. Methods and Materials: A retrospective evaluation was performed in 9 prostate cancer patients who had undergone MR-SIM in addition to CT simulation (CT-SIM). MR-SIM data were used to generate synCT images by using a novel, voxel-based weighted summation approach. A subset of patients was used for weight optimization, and the number of patients to use during optimization was determined. Hounsfield unit (HU) differences between CT-SIM and synCT images were analyzed via mean absolute error (MAE). Original, CT-based treatment plans were mapped onto synCTs. DRRs were generated, and agreement between CT and synCT-generated DRRs was evaluated via Dice similarity coefficient (DSC). Dose was recalculated, and dose-volume metrics and gamma analysis were used to evaluate resulting treatment plans. Results: Full field-of-view synCT MAE across all patients was 74.3 ± 10.9 HU with differences from CTs of 2.0 ± 8.1 HU and 11.9 ± 46.7 HU for soft tissue structures (prostate, bladder, and rectum) and femoral bones, respectively. Calculated DSCs for anterior-posterior and lateral DRRs were 0.90 ± 0.04 and 0.92 ± 0.05, respectively. Differences in D99%, mean dose, and maximum dose to the clinical target volume from CT-SIM dose calculations were 0.75% ± 0.35%, 0.63% ± 0.34%, and 0.54% ± 0.33%, respectively, for synCT-generated plans. Gamma analysis (2%/2 mm dose difference/distance to agreement) revealed pass rates of 99.9% ± 0.1% (range, 99.7%-100%). Conclusion: Generated synCTs enabled accurate DRR generation and dose computation for prostate MR-only simulation. Dose recalculated on synCTs agreed well with original planning distributions. Further validation using a larger patient

  3. Endoscopic mucosal resection of early gastric cancer: initial experience with two technical variants Mucosectomia endoscópica no câncer gástrico precoce: experiência inicial com duas variantes técnicas

    Directory of Open Access Journals (Sweden)

    Paulo Moacir de Oliveira Campoli

    2007-09-01

    Full Text Available BACKGROUND: When performed in carefully selected cases, the endoscopic treatment of early gastric cancer yields results which are comparable to the conventional surgical treatment, but with lower morbidity and mortality and better quality of life. Several technical options to perform endoscopic mucosal resection have been described and there is a large amount of accumulated experience with this procedure in eastern countries. In western countries, particularly in Brazil, technical limitations associated with the small number of cases of early gastric cancer reflect the little experience with this therapeutic mode. AIM: This study was carried out in order to assess the indications, pathological results and morbidity of a series of endoscopic mucosal resections using two technical variants in addition to investigating the safety and feasibility of the method. METHODS: Individuals with well-differentiated early gastric adenocarcinomas with up to 30 mm in diameter without scar or ulcer underwent endoscopic treatment. Two variants of the strip biopsy technique were used. The pathological study assessed the depth of the vertical invasion, lateral and basal margins as well as angio-lymphatic invasion. RESULTS: Thirteen tumors in 12 patients were resected between June 2002 and August 2005. The most common macroscopic types were IIa and IIa + IIc. Tumor size ranged from 10 to 30 mm (mean = 16.5 mm. En bloc resection was carried out in nine patients. Angio-lymphatic invasion was not observed; however, submucosal invasion was found in two cases. In four cases, the lateral margin was involved. Perforation occurred in two patients who then received conservative treatment. CONCLUSION: The relatively small series presented here suggests that the method is safe and feasible. Appropriate patient selection is the most important criteria. Long follow-up is required after treatment due to the risk of relapse.RACIONAL: O tratamento endoscópico do câncer g

  4. Assessing Employability Skills of Technical-Vocational Students in Malaysia

    OpenAIRE

    Ab. R. Bakar; Ivan Hanafi

    2007-01-01

    Technical-Vocational Education and Training (TVE) system plays important role in providing highly skilled workforce to fulfill the needs of industries. An empirical research of TVE system is necessary to identify effective TVE system to successfully equip students with technical skills that would enable them to fulfill the current work demands and professional expectations. The objective of this paper is to present the findings of TVE system implementation in one of the technical training ins...

  5. Technical Training Seminar

    CERN Document Server

    2003-01-01

    Thursday 4 September From 14:00 to 17:00 - Training Centre Auditorium bldg. 593, room 11 The Summit Design VisualElite 4.0 Release Jean Marie St Paul / SUMMIT DESIGN, Europe, Technical Manager Michel Delcroix / SUMMIT DESIGN, Southern Europe, Sales F-95015 CERGY PONTOISE, France Summit Design is an important EDA digital hardware design tool supplier, and the industry leader in the emerging Electronic System Level design domain. Its VisualElite program has been used at CERN for several years. This seminar will include the highlights of the program's latest release. It will be illustrated how Summit Design products can provide a high-level C/C++ and SystemC functional modelling design and verification environment, enabling engineers to analyse system concepts before the implementation stage. The seminar will show how mixed SystemC and HDL simulation can be done, along with solutions for hardware/software development. • HDL new features: Connectivity Table Editor. Xemacs full integration. New NCsi...

  6. Technical Training Seminar

    CERN Document Server

    2003-01-01

    Thursday 4 September From 14:00 to 17:00 - Training Centre Auditorium bldg. 593, room 11 The Summit Design VisualElite 4.0 Release Jean Marie St Paul / SUMMIT DESIGN, Europe, Technical Manager Michel Delcroix / SUMMIT DESIGN, Southern Europe, Sales F-95015 CERGY PONTOISE, France Summit Design is an important EDA digital hardware design tool supplier, and the industry leader in the emerging Electronic System Level design domain. Its VisualElite program has been used at CERN for several years. This seminar will include the highlights of the program's latest release. It will be illustrated how Summit Design products can provide a high-level C/C++ and SystemC functional modelling design and verification environment, enabling engineers to analyse system concepts before the implementation stage. The seminar will show how mixed SystemC and HDL simulation can be done, along with solutions for hardware/software development. • HDL new features: Connectivity Table Editor. Xemacs full integration. New NCsim ...

  7. Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Dmitriy Y. Anistratov; Marvin L. Adams; Todd S. Palmer; Kord S. Smith; Kevin Clarno; Hikaru Hiruta; Razvan Nes

    2003-08-04

    OAK B202 Final Technical Report. The present generation of reactor analysis methods uses few-group nodal diffusion approximations to calculate full-core eigenvalues and power distributions. The cross sections, diffusion coefficients, and discontinuity factors (collectively called ''group constants'') in the nodal diffusion equations are parameterized as functions of many variables, ranging from the obvious (temperature, boron concentration, etc.) to the more obscure (spectral index, moderator temperature history, etc.). These group constants, and their variations as functions of the many variables, are calculated by assembly-level transport codes. The current methodology has two main weaknesses that this project addressed. The first weakness is the diffusion approximation in the full-core calculation; this can be significantly inaccurate at interfaces between different assemblies. This project used the nodal diffusion framework to implement nodal quasidiffusion equations, which can capture transport effects to an arbitrary degree of accuracy. The second weakness is in the parameterization of the group constants; current models do not always perform well, especially at interfaces between unlike assemblies. The project developed a theoretical foundation for parameterization and homogenization models and used that theory to devise improved models. The new models were extended to tabulate information that the nodal quasidiffusion equations can use to capture transport effects in full-core calculations.

  8. Waste management project technical baseline description

    Energy Technology Data Exchange (ETDEWEB)

    Sederburg, J.P.

    1997-08-13

    A systems engineering approach has been taken to describe the technical baseline under which the Waste Management Project is currently operating. The document contains a mission analysis, function analysis, requirement analysis, interface definitions, alternative analysis, system definition, documentation requirements, implementation definitions, and discussion of uncertainties facing the Project.

  9. Wisconsin's Technical School of the Air.

    Science.gov (United States)

    Brumm, Loren

    The Technical Scoool of the Air was developed to deliver video-based courses via boradcast and cable television. The system was designed to implement competency-based instructional courses and programs statewide. An audio visual material production consortium was established to facilitate joint production/acquisition efforts, reduce duplicate…

  10. Technical aspects of high converter reactors

    International Nuclear Information System (INIS)

    The meeting provided an opportunity to review and discuss national R and D programs, various technical aspects of and worldwide progress in the implementation of high conversion reactors. The meeting was attended by 66 participants from 18 countries and 2 international organizations. 33 papers were presented. A separate abstract was prepared for each of these papers. Refs, figs, tabs, slides and diagram

  11. Waste management project technical baseline description

    International Nuclear Information System (INIS)

    A systems engineering approach has been taken to describe the technical baseline under which the Waste Management Project is currently operating. The document contains a mission analysis, function analysis, requirement analysis, interface definitions, alternative analysis, system definition, documentation requirements, implementation definitions, and discussion of uncertainties facing the Project

  12. Technical Cooperation Report for 2014. Report by the Director General

    International Nuclear Information System (INIS)

    enhancements to the Project Progress Assessment Report. Part B of this document presents a summary of financial and non-financial programme delivery indicators. It reviews the resources mobilized for the TC programme through the Technical Cooperation Fund (TCF), and through extrabudgetary and in-kind contributions. Payments to the TCF in 2014 totalled €62.0 million (not including National Participation Costs, assessed programme costs or miscellaneous income), or 89.5% of the TCF target set for the year. New extrabudgetary resources for 2014 came to €18.6 million and in-kind contributions were €0.6 million. Overall, implementation for the TCF reached 78% in 2014. Part C of this document responds to the operative paragraphs of resolution GC(58)/RES/12, and covers assistance to Member States in the peaceful, safe, secure and regulated application of atomic energy and nuclear techniques in specific fields. It highlights regional activities and achievements in technical cooperation in 2014. Globally, health and nutrition accounted for the highest proportion of actuals1 through the TC programme in 2014, followed by safety and security, and then by food and agriculture. Project examples are presented in Annex 1 according to thematic area, covering health and nutrition, food and agriculture, water and the environment, industrial applications, energy planning and nuclear power, radiation protection, nuclear safety and nuclear security, and nuclear knowledge development and management. The activities of the Programme of Action for Cancer Therapy are covered in Annex 2

  13. Implementing PAT with Standards

    Science.gov (United States)

    Chandramohan, Laakshmana Sabari; Doolla, Suryanarayana; Khaparde, S. A.

    2016-02-01

    Perform Achieve Trade (PAT) is a market-based incentive mechanism to promote energy efficiency. The purpose of this work is to address the challenges inherent to inconsistent representation of business processes, and interoperability issues in PAT like cap-and-trade mechanisms especially when scaled. Studies by various agencies have highlighted that as the mechanism evolves including more industrial sectors and industries in its ambit, implementation will become more challenging. This paper analyses the major needs of PAT (namely tracking, monitoring, auditing & verifying energy-saving reports, and providing technical support & guidance to stakeholders); and how the aforesaid reasons affect them. Though current technologies can handle these challenges to an extent, standardization activities for implementation have been scanty for PAT and this work attempts to evolve them. The inconsistent modification of business processes, rules, and procedures across stakeholders, and interoperability among heterogeneous systems are addressed. This paper proposes the adoption of specifically two standards into PAT, namely Business Process Model and Notation for maintaining consistency in business process modelling, and Common Information Model (IEC 61970, 61968, 62325 combined) for information exchange. Detailed architecture and organization of these adoptions are reported. The work can be used by PAT implementing agencies, stakeholders, and standardization bodies.

  14. Coeur d'Alene Tribe Fisheries Program Research, Monitoring and Evaluation Plan; Implementation of Fisheries Enhancement Opportunities on the Coeur d'Alene Reservation, 1997-2002 Technical Report.

    Energy Technology Data Exchange (ETDEWEB)

    Vitale, Angelo; Lamb, Dave; Peters, Ronald

    2002-11-01

    Westslope cutthroat trout (Oncorhynchus clarki lewisi) and bull trout (Salvelinus confluentus) are currently of special concern regionally and are important to the culture and subsistence needs of the Coeur d'Alene Tribe. The mission of the Coeur d'Alene Tribe Fisheries Program is to restore and maintain these native trout and the habitats that sustain them in order to provide subsistence harvest and recreational fishing opportunities for the Reservation community. The adfluvial life history strategy exhibited by westslope cutthroat and bull trout in the Lake Coeur d'Alene subbasin makes these fish susceptible to habitat degradation and competition in both lake and stream environments. Degraded habitat in Lake Coeur d'Alene and its associated streams and the introduction of exotic species has lead to the decline of westslope cutthroat and listing of bull trout under the endangered species act (Peters et al. 1998). Despite the effects of habitat degradation, several streams on the Reservation still maintain populations of westslope cutthroat trout, albeit in a suppressed condition (Table 1). The results of several early studies looking at fish population status and habitat condition on the Reservation (Graves et al. 1990; Lillengreen et al. 1993, 1996) lead the Tribe to aggressively pursue funding for habitat restoration under the Northwest Power Planning Council's (NWPPC) resident fish substitution program. Through these efforts, habitat restoration needs were identified and projects were initiated. The Coeur d'Alene Tribe Fisheries Program is currently involved in implementing stream habitat restoration projects, reducing the transport of sediment from upland sources, and monitoring fish populations in four watersheds on the Coeur d'Alene Reservation (Figure 1). Restoration projects have included riparian plantings, addition of large woody debris to streams, and complete channel reconstruction to restore historical natural

  15. 75 FR 35973 - Trademark Technical and Conforming Amendments

    Science.gov (United States)

    2010-06-24

    ... Conforming Amendments AGENCY: United States Patent and Trademark Office, Commerce. ACTION: Interim final rule... amending the Rules of Practice in Trademark Cases to implement the Trademark Technical and Conforming... Technical and Conforming Amendment Act of 2010 became effective on March 17, 2010. Public Law 111-146,...

  16. The Agency's technical co-operation activities in 1993

    International Nuclear Information System (INIS)

    This document reviews the IAEA's Technical Cooperation activities for 1993. Apart from an overview, the report contains reviews by Agency programmes and technical divisions, by area, by component and by fund. Summaries of project implementation are also included, as well as indications of the achievements of projects completed in 1993

  17. Technical rules in law

    International Nuclear Information System (INIS)

    An important source of knowledge for technical experts is the state of the art reflected by catalogues of technical rules. Technical rules may also achieve importance in law due to a legal transformation standard. Here, rigid and flexible reference are controversial with regard to their admissibility from the point of view of constitutional law. In case of a divergence from the generally accepted technical rules, it is assumed - refutably - that the necessary care had not been taken. Technical rules are one out of several sources of information; they have no normative effect. This may result in a duty of anyone applying them to review the state of technology himself. (orig.)

  18. Technical Support | Division of Cancer Prevention

    Science.gov (United States)

    To view the live webinar, you will need to have the software, Microsoft Live Meeting, downloaded onto your computer before the event. In most cases, the software will automatically download when you open the program on your system. However, in the event that you need to download it manually, you can access the software at the link below: Download the Microsoft Office Live Meeting 2007 client  |

  19. LOGISTIC MANAGEMENT MATERIALS-TECHNICAL SUPPORT RAILWAY ENTERPRISES

    OpenAIRE

    Dykan, V.; Borozenetc, T.

    2014-01-01

    The essence of logistics management. Determine the feasibility of applying the principles of logistics management in organizing the logistics of railway transport. Discussed measures to develop suppliers in the implementation of logistics management logistics. Identified the need to develop and implement regulatory and methodical system to improve materials-technical support through the introduction of modern logistics principles. Applied systemic campaign to organize the materials-technical ...

  20. Cancer Statistics: Endometrial Cancer

    Science.gov (United States)

    ... a third party. HPF: Did You Know? Endometrial Cancer Endometrial Cancer - Did you know that endometrial cancer ... mfhs0vbvWi8?rel=0 SEER Stat Fact Sheets: Endometrial Cancer Expand All Collapse All Lifetime risk estimates are ...

  1. Development and implementation of the National Cancer Institute's Food Attitudes and Behaviors Survey to assess correlates of fruit and vegetable intake in adults.

    Directory of Open Access Journals (Sweden)

    Temitope O Erinosho

    Full Text Available Low fruit and vegetable (FV intake is a leading risk factor for chronic disease globally as well as in the United States. Much of the population does not consume the recommended servings of FV daily. This paper describes the development of psychosocial measures of FV intake for inclusion in the U.S. National Cancer Institute's 2007 Food Attitudes and Behaviors Survey.This was a cross-sectional study among 3,397 adults from the United States. Scales included conventional constructs shown to be correlated with fruit and vegetable intake (FVI in prior studies (e.g., self-efficacy, social support, and novel constructs that have been measured in few- to- no studies (e.g., views on vegetarianism, neophobia. FVI was assessed with an eight-item screener. Exploratory factor analysis, Cronbach's alpha, and regression analyses were conducted.Psychosocial scales with Cronbach's alpha ≥0.68 were self-efficacy, social support, perceived barriers and benefits of eating FVs, views on vegetarianism, autonomous and controlled motivation, and preference for FVs. Conventional scales that were associated (p<0.05 with FVI were self-efficacy, social support, and perceived barriers to eating FVs. Novel scales that were associated (p<0.05 with FVI were autonomous motivation, and preference for vegetables. Other single items that were associated (p<0.05 with FVI included knowledge of FV recommendations, FVI "while growing up", and daily water consumption.These findings may inform future behavioral interventions as well as further exploration of other potential factors to promote and support FVI.

  2. Coeur d'Alene Tribe Fish and Wildlife Program Habitat Protection Plan; Implementation of Fisheries Enhancement Opportunities on the Coeur d'Alene Reservation, 1997-2002 Technical Report.

    Energy Technology Data Exchange (ETDEWEB)

    Vitale, Angelo; Roberts, Frank; Peters, Ronald

    2002-06-01

    , including the Coeur d'Alene Indian Reservation (Coeur d'Alene Tribe 1998). Implicit in this statement is a commitment to provide native subsistence resources in the present and near future as well as the long-term by employing all the mitigation and conservation measures available to them. The development of this Habitat Protection Plan is intended to provide additional planning level guidance as the implementation of conservation measures moves forward. The purpose of this plan is to develop a systematic approach to habitat restoration that will ultimately lead to self-perpetuating, harvestable populations of native fish, wildlife and botanical species. Specifically, it is our intention to apply the principles and analyses presented in this plan to prioritize future restoration efforts that receive funding under the Northwest Power Planning Council's Resident Fish and Wildlife Mitigation Programs. Using an ecosystem restoration approach based on landscape ecology concepts (Primack 1993), the basic premise of the plan is to (1) protect functioning habitat conditions and (2) restore degraded habitat conditions. This plan focuses on habitat conditions at the watershed scale (macrohabitat) rather than on the needs of single species and/or species guilds. By focusing restoration efforts at a macrohabitat level, restoration efforts target all native species inhabiting that area. This approach marks a paradigm shift that emphasizes ecological based restoration rather than species-specific restoration. Traditionally, fish managers and wildlife managers have approached restoration independently, often dedicating resources to a single species by focusing on specific habitat types on a small spatial scale (microhabitat) (Robinson and Bolen 1989, Marcot et al. 2002). This management technique has done little to curb declines despite large budgets (Pianka 1994). Restoration on a landscape level has shown promising results (Holling 1992) and many riparian and wetland

  3. Implementing Secure Group Communications using Key Graphs

    Directory of Open Access Journals (Sweden)

    Ch. Aswani Kumar

    2007-03-01

    Full Text Available While the technical issues of securing unicast communications for client-server computingare fairly well-understood, the technical issues of securing group communications are not. Theexisting approach to improve the scalability is to decompose a large group of clients into manysubgroups and employ a hierarchy of group security agents. In this paper, the secure groupcommunications using key graphs and the implementation of a different hierarchical approachto improve the scalability and secure group communication using key graphs has been presented.

  4. Implementing Software Defined Radio

    CERN Document Server

    Grayver, Eugene

    2013-01-01

    Software Defined Radio makes wireless communications easier, more efficient, and more reliable. This book bridges the gap between academic research and practical implementation. When beginning a project, practicing engineers, technical managers, and graduate students can save countless hours by considering the concepts presented in these pages. The author covers the myriad options and trade-offs available when selecting an appropriate hardware architecture. As demonstrated here, the choice between hardware- and software-centric architecture can mean the difference between meeting an aggressive schedule and bogging down in endless design iterations. Because of the author’s experience overseeing dozens of failed and successful developments, he is able to present many real-life examples. Some of the key concepts covered are: Choosing the right architecture for the market – laboratory, military, or commercial Hardware platforms – FPGAs, GPPs, specialized and hybrid devices Standardization efforts to ens...

  5. 护理风险管理在乳腺癌化疗病房的应用%Effect of implementing risk management in the breast cancer chemotherapy ward

    Institute of Scientific and Technical Information of China (English)

    陈国珍; 郑婉婷; 陈殷琴

    2012-01-01

    Objective To explore the effect of implementing risk management in the breast cancer chemotherapy ward.Methods The breast cancer chemotherapy patients between January 2011 and June 2011 were retrospectively surveyed and analyzed the factors that may caused drug extravasation and took the appropriate care risk management measures,nurses received the intervention between July 2011 and December 2011,the situation of drug leaking was investigated and the nurses' cognition on drug chemotherapy before and after intervention was assessed,Results After implementing care risk management,the leakage rate of chemotherapy drug was decreased 5.7%,and no skin necrosis occurred.The nurses' professional knowledge about the usage of chemotherapy drug was obviously improved than that before intervention,and the difference was statistically significant (x2 =4.727,6.190,4.887,4.887 ; P < 0.05).Conclusions Implementing risk management in breast cancer chemotherapy ward can reduce the risk of care in chemotherapy and improve the nurses' professional knowledge.%目的 探讨在乳腺癌化疗病房实施护理风险管理的效果.方法 对2011年1-6月行乳腺癌化疗的患者进行回顾性调查,分析可能引起药物外渗的因素并采取相应的护理风险管理措施;并于201 1年7-12月对护理人员进行干预,对药物渗出情况进行前瞻性调查,分别评估干预前及干预后护士对化疗药物的认知情况.结果 实施护理风险管理后,化疗药物的渗出率较干预前下降了5.7%,无皮肤坏死的情况发生;护士对化疗药物使用的专业知识认知水平较干预前明显提高,两者比较差异有统计学意义(x2值分别为4.727,6.190,4.887,4.887;P<0.05).结论 在乳腺癌化疗病房实施护理风险管理有助于减少化疗过程中的护理风险,提高护士的专业知识认知水平.

  6. Report of the first meeting of the Project Advisory Committee (Technical) 21-24 March 1983, at NEMROCK, Cairo

    International Nuclear Information System (INIS)

    The Project Advisory Committee (Technical) (PACT) met on 21-24 March 1983, at NEMROCK, Cairo, Egypt, to discuss the joint IAEA/WHO project on Intracavitary Radiation Therapy for Cancer of the Uterus (Egypt/6/004). At this four day meeting the committee (1) identified a well-defined administrative framework in which earlier diagnosis of uterine cancer may be organized, on a limited but firm basis. (2) Agreed on the clinical and dosimetric principles to be followed in implementing the project. (3) Decided on the types and quantities of equipment which it will need in its first two years. (4) Developed the outline of the syllabus for the first training course, and fixed its date (three weeks from 83-10-29). (5) Reviewed the costs which will be incurred in carrying through the project and found them to be consistent with the funds available

  7. Cancer - resources

    Science.gov (United States)

    Resources - cancer ... The following organizations are good resources for information on cancer : American Cancer Society -- www.cancer.org Cancer Care -- www.cancercare.org National Cancer Institute -- www.cancer.gov

  8. Cancer Statistics

    Science.gov (United States)

    ... What Is Cancer? Cancer Statistics Cancer Disparities Cancer Statistics Cancer has a major impact on society in ... success of efforts to control and manage cancer. Statistics at a Glance: The Burden of Cancer in ...

  9. A comparison of two methods for estimating DCE-MRI parameters via individual and cohort based AIFs in prostate cancer: a step towards practical implementation.

    Science.gov (United States)

    Fedorov, Andriy; Fluckiger, Jacob; Ayers, Gregory D; Li, Xia; Gupta, Sandeep N; Tempany, Clare; Mulkern, Robert; Yankeelov, Thomas E; Fennessy, Fiona M

    2014-05-01

    Multi-parametric Magnetic Resonance Imaging, and specifically Dynamic Contrast Enhanced (DCE) MRI, play increasingly important roles in detection and staging of prostate cancer (PCa). One of the actively investigated approaches to DCE MRI analysis involves pharmacokinetic (PK) modeling to extract quantitative parameters that may be related to microvascular properties of the tissue. It is well-known that the prescribed arterial blood plasma concentration (or Arterial Input Function, AIF) input can have significant effects on the parameters estimated by PK modeling. The purpose of our study was to investigate such effects in DCE MRI data acquired in a typical clinical PCa setting. First, we investigated how the choice of a semi-automated or fully automated image-based individualized AIF (iAIF) estimation method affects the PK parameter values; and second, we examined the use of method-specific averaged AIF (cohort-based, or cAIF) as a means to attenuate the differences between the two AIF estimation methods. Two methods for automated image-based estimation of individualized (patient-specific) AIFs, one of which was previously validated for brain and the other for breast MRI, were compared. cAIFs were constructed by averaging the iAIF curves over the individual patients for each of the two methods. Pharmacokinetic analysis using the Generalized kinetic model and each of the four AIF choices (iAIF and cAIF for each of the two image-based AIF estimation approaches) was applied to derive the volume transfer rate (K(trans)) and extravascular extracellular volume fraction (ve) in the areas of prostate tumor. Differences between the parameters obtained using iAIF and cAIF for a given method (intra-method comparison) as well as inter-method differences were quantified. The study utilized DCE MRI data collected in 17 patients with histologically confirmed PCa. Comparison at the level of the tumor region of interest (ROI) showed that the two automated methods resulted in

  10. Radiation cancer analysis and low dose risk estimation: new developments and perspectives - conference to be held Feb 2002. Final technical report for period November 1, 2001--October 31, 2002

    International Nuclear Information System (INIS)

    The Proceedings of the 20th LH Gray Conference on Radiation Cancer Analysis and Low Dose Risk Estimation: New Developments and Perspectives (17-21 February 2002, Ede, the Netherlands) comprises 32 peer-reviewed papers on invited and proffered contributions to the conference with a preface by the guest editors. The on-going discussion of low dose radiation risk; the issue of the linear, non-threshold extrapolation; and the anticipated new recommendations, e.g. from BEIR and ICRP, provided the back-drop for the conference. The meeting dealt with topics such as basic mechanisms and bystander effects, cancer modeling, cancer genetics, radon exposure and lung cancer risk, cancer after medical exposure, cancer risk estimation, dose-effect relationships, and application to radiation protection

  11. 6 Common Cancers - Prostate Cancer

    Science.gov (United States)

    ... PSA tests. Read More "6 Common Cancers" Articles Lung Cancer / Breast Cancer / Prostate Cancer / Colorectal Cancer / Skin Cancer / Gynecologic Cancers Spring 2007 Issue: Volume 2 Number 2 Page 10 MedlinePlus | Subscribe | Magazine Information | Contact Us | Viewers & ...

  12. 6 Common Cancers - Colorectal Cancer

    Science.gov (United States)

    ... certain people. Read More "6 Common Cancers" Articles Lung Cancer / Breast Cancer / Prostate Cancer / Colorectal Cancer / Skin Cancer / Gynecologic Cancers Spring 2007 Issue: Volume 2 Number 2 Page 11 MedlinePlus | Subscribe | Magazine Information | Contact Us | Viewers & ...

  13. Towards clinical implementation of ultrafast combined kV-MV CBCT for IGRT of lung cancer. Evaluation of registration accuracy based on phantom study

    Energy Technology Data Exchange (ETDEWEB)

    Arns, Anna; Blessing, Manuel; Fleckenstein, Jens; Stsepankou, Dzmitry; Boda-Heggemann, Judit; Simeonova-Chergou, Anna; Hesser, Juergen; Lohr, Frank; Wenz, Frederik; Wertz, Hansjoerg [University Medical Center Mannheim, University of Heidelberg, Department of Radiation Oncology, Mannheim (Germany)

    2016-05-15

    Combined kV-MV cone-beam CT (CBCT) is a promising approach to accelerate imaging for patients with lung tumors treated with deep inspiration breath-hold. During a single breath-hold (15 s), a 3D kV-MV CBCT can be acquired, thus minimizing motion artifacts and increasing patient comfort. Prior to clinical implementation, positioning accuracy was evaluated and compared to clinically established imaging techniques. An inhomogeneous thorax phantom with four tumor-mimicking inlays was imaged in 10 predefined positions and registered to a planning CT. Novel kV-MV CBCT imaging (90 arc) was compared to clinically established kV-chest CBCT (360 ) as well as nonclinical kV-CBCT and low-dose MV-CBCT (each 180 ). Manual registration, automatic registration provided by the manufacturer and an additional in-house developed manufacturer-independent framework based on the MATLAB registration toolkit were applied. Systematic setup error was reduced to 0.05 mm by high-precision phantom positioning with optical tracking. Stochastic mean displacement errors were 0.5 ± 0.3 mm in right-left, 0.4 ± 0.4 mm in anteroposterior and 0.0 ± 0.4 mm in craniocaudal directions for kV-MV CBCT with manual registration (maximum errors of no more than 1.4 mm). Clinical kV-chest CBCT resulted in mean errors of 0.2 mm (other modalities: 0.4-0.8 mm). Similar results were achieved with both automatic registration methods. The comparison study of repositioning accuracy between novel kV-MV CBCT and clinically established volume imaging demonstrated that registration accuracy is maintained below 1 mm. Since imaging time is reduced to one breath-hold, kV-MV CBCT is ideal for image guidance, e.g., in lung stereotactic ablative radiotherapy. (orig.) [German] Kombiniertes kV-MV-Cone-Beam-CT (CBCT) ist ein vielversprechender Ansatz zur Beschleunigung der Bildgebung bei Patienten mit Lungentumoren, die mit wiederholter Atemanhaltetechnik in tiefer Inspiration behandelt werden. Waehrend einer einzigen

  14. IMPROVEMENT OF TECHNICAL EDUCATION IN PUBLIC TECHNICAL SECONDARY SCHOOLS (ECOLE TECHNIQUE OFFICIEL - ETOS IN RWANDA

    Directory of Open Access Journals (Sweden)

    Maina Maringa

    2010-05-01

    Full Text Available This paper presents a brief review of the state of technical education in Rwanda based on a study conducted in 2007, with pertinent recommendations. The background of technical education in the country is appreciated first, and then followed up with a situational analysis. Thereafter, a 5-year implementation project plan proposal, to address the identified shortcomings, needs, and expectations of government is advanced. The need to raise access to post tronc commun (post O-Level technical training is addressed within this proposal with a specific interest to increase the capacity and range of programmes running in the existing ETOs, and the introduction of new ETOs where deemed necessary. The establishment and sustenance of a good quality technical education system is also given consideration in this proposal for effective and efficient rehabilitation of existing physical facilities and the purchase of new and appropriate training equipment. Simultaneously, considerations for increasing the number of technical teachers in the system to a determined optimum level while setting minimum acceptable qualifications for technical teachers are advanced. Implementation of this proposal is expected to contribute greatly to the continuous development of a labour pool with skills that are relevant to and adequate for the needs of the economy.

  15. On the Building and Implementation of the Flipped Classroom Teaching Model Suitable for the Secondary Vocational Technical Schools——FLASH boot path animation courses as on example%中职翻转课堂模型构建与实施研究——以FLASH引导路径动画课程为例

    Institute of Scientific and Technical Information of China (English)

    王小红

    2015-01-01

    For today's education"student-centered"teaching philosophy, this paper proposes the flipped classroom teaching mode and makes full use of the advantages of flip classroom to build flipped classroom teaching model suitable for the Secondary vocational technical schools.Taking"FLASH boot path animation course"for example, this paper designs flipped classroom teaching programs based on autonomous learning, detects problems in the implementation process, gradually perfects the flipped classroom, improves the ability of autonomous learning, and truly realize the idea of"my learning on my own terms".%针对当今教育"以学生为中心"的教学理念,本文提出翻转课堂的教学模式,充分利用翻转课堂的优势,构建适合中职的翻转课堂教学模型,以"FLASH引导路径动画"课程为例,设计基于学生自主学习的翻转课堂的教学方案,并在实施过程中及时发现问题,逐步完善翻转课堂,提高学生自主学习的能力,真正做到"我的学习我做主".

  16. Technical and economical analysis for the implementation of small scale GTL (Gas-to-liquids) technology to monetizing the associated remote offshore stranded natural gas in Brazil; Analise tecnica e economica da aplicacao da tecnologia GTL de pequena escala para a monetizacao do gas natural associado remoto offshore no Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Castelo Branco, David Alves

    2008-02-15

    The volume of stranded natural gas global reserves is substantial and represents more than a third of the world's proven natural gas reserves. In Brazil, recent discoveries operated by PETROBRAS, with participation of other companies, show trend of stranded gas reserves incorporation, associated gas or not. This dissertation's main objective is to make a technical and economic analysis of the implementation of small-scale GTL technology for the exploitation of stranded associated natural gas offshore in Brazil. Thus, the dissertation held, initially, a survey of the processes of gasification and the manufacturers with technologies and projects based on these processes, for specific offshore applications. In a second stage, the conditions of the offshore environment were examined. After the confrontation of the technologies available and the operation conditions, a technological alternative has been chosen to be used in an illustrative economic analysis. The results show that GTL offshore option becomes viable at a minimum price of about US $ 40.00 / barrel. Although this value is greater than the robustness price adopted by PETROBRAS, there are prospects for the reduction of GTL technology costs. (author)

  17. ENS implementation

    Energy Technology Data Exchange (ETDEWEB)

    Teodorescu, R.; Blaabjerg, F.; Asiminoaei, L.; Timbus, A.V.

    2004-07-01

    This report is part of the research contract PSO-Eltra 2524/2003 where Aalborg University did cooperated with PowerLynx A/S for the development of the ENS function for the PowerLynx PV inverters. The work started 01.01.03 and ended 29.02.04 and involved Frede Blaabjerg, Remus Teodorescu, Lucian Asiminoaie and Adrian Timbus from Aalborg University and Uffe Borup from PowerLynx A/S. The objective was to make the PowerLynx PV inverters compatible with the german ENS standard which mainly consist in the requirement to disconnect from the grid in max. 2 seconds if the grid impedance is changed with 0.5 ohms resistive. During 01.07 31.08 2003, an algorithm based on the injection of a voltage of 75 Hz and the on-line measurement the 75Hz component from the grid current and voltage using simplified DFT was developed by Uffe Borup, Remus Teodorescu and Lucian Asiminoaie. The algorithm is described in detail in the report 'ENS design' enclosed in Appendix A and in the two published paper (final paper for APEC'04 and approved digest for PESC'04). Then the algorithm was finally implemented and the experimental tests carried out proved to be satisfactory as shown in chapter 2 'ENS implementation'. Very few missed tests were recorded on very high inductive grid (0.6 + 1.1i) when the reactance is higher than the resistance. In the period 03.02.04 13.02.04 some attempts was done in order to improve the detection by compensating the delay in the voltage measurement but no improvement was noticed. Thus, these last minute changes was not included in the final version of the software. Finally, the detection mechanism of another PV running in parallel that injects t5Hz for ENS grid measurements has been done. The code for parallel ENS is also enclosed. (au)

  18. LSST operation simulator implementation

    Science.gov (United States)

    Delgado, Francisco; Cook, Kem; Miller, Michelle; Allsman, Robyn; Pierfederici, Francesco

    2006-06-01

    We have developed an operation simulator for the Large Synoptic Survey Telescope (LSST) that is an implementation in Python language using the SimPy extension, with a modular and object-oriented design. The main components include a telescope model, a sky model, a weather database for 3 sites, a scheduler and multiple observing proposals. All the proposals derive from a parent class which is fully configurable through about 75 parameters to implement a specific science survey. These parameters control the target selection region, the composition of the sequence of observations for each field, the timing restrictions and filter selection criteria of each observation, the lunation handling, seeing limits, etc. The current implemented proposals include Weak Lensing, Near Earth Asteroids, Supernova and Kuiper Belt Objects. The telescope model computes the slew time delay from the current position to any given target position, using a complete kinematic model for the mount, dome and rotator, as well as optics alignment corrections. The model is fully configurable through about 50 parameters. The scheduler module combines the information received from the proposals and the telescope model for selecting the best target at each moment, promoting targets that fulfill multiple surveys and storing all the simulator activities in a MySQL database for further analysis of the run. This scheduler is also configurable; for example, balancing the weight of the slew time delay in selecting the next field to observe. This simulator has been very useful in clarifying some of the technical and scientific capabilities of the LSST design, and gives a good baseline for a future observation scheduler.

  19. Technical Communication in Japan

    Institute of Scientific and Technical Information of China (English)

    Hiraku Amemiya

    2010-01-01

    @@ 1.Characteristics of Japanese Technical Communication(TC) The visual orientation of information characterizes Japanese technical communication.Manuals that have won Japan Manual Awards in the past have employed various designs with graphical presentations that evoke the style of popular magazines.

  20. Transformation of technical infrastructure

    DEFF Research Database (Denmark)

    Nielsen, Susanne Balslev

    1998-01-01

    article about the need of new planning forums in order to initiate transformations with in management of large technical systems for energy, waste and water supply.......article about the need of new planning forums in order to initiate transformations with in management of large technical systems for energy, waste and water supply....

  1. Technical Manual. The ACT®

    Science.gov (United States)

    ACT, Inc., 2014

    2014-01-01

    This manual contains technical information about the ACT® college readiness assessment. The principal purpose of this manual is to document the technical characteristics of the ACT in light of its intended purposes. ACT regularly conducts research as part of the ongoing formative evaluation of its programs. The research is intended to ensure that…

  2. Summer Technical Students 2004

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    About 100 technical and doctoral students arrive each year, undergraduates and post-graduates who are preparing diploma or doctoral theses in applied science and technology. They spend up to two years at the Laboratory, as technical students as part of their formal training for a recognised degree or its equivalent.

  3. Technical Agency in Practice

    DEFF Research Database (Denmark)

    Krummheuer, Antonia Lina

    2015-01-01

    The paper combines the discussion of technical agency and hybrid networks of Actor-Network Theory (ANT) with an ethnomethodological/conversation analytical (EMCA) perspective on situated practices in which participants ascribe agency to technical artefacts. While ANT works with (ethnographic......) description of hybrid networks in which human and non-human actants are granted agency without differentiating different kinds of agency, EMCA focuses on the member's perspectives and the situated construction of technical agency that is made relevant within an ongoing interaction. Based on an EMCA analysis...... of three video recordings of situations in which technical agency is made relevant by the human participants, the paper demonstrates different ways in which agency is granted to technical artefacts. Human participants can treat a technology as communication partner, as an active part (and actant...

  4. Accelerated repopulation as a cause of radiation treatment failure in non-small cell lung cancer: review of current data and future clinical strategies.

    Science.gov (United States)

    Yom, Sue S

    2015-04-01

    Despite convincing evidence that the principles of accelerated repopulation would open up additional therapeutic opportunities in the treatment of advanced-stage non-small cell lung cancer, this strategy has been generally underexplored. The implementation of accelerated radiotherapy schedules has been hampered by logistical barriers, concerns about acute toxicity, and the prioritization of integrating concurrent chemotherapy into the standard treatment platform. At present, it is unclear to what extent accelerated fractionation will influence future treatment paradigms in non-small cell lung cancer, although technical advances in radiotherapy, allowing higher dose delivery with reduced toxicity, could permit the development of more convenient and tolerable forms of accelerated schedules. PMID:25771413

  5. Individual dosimetry of workers and patients: implementation and perspectives

    International Nuclear Information System (INIS)

    These days organised by the section of the technical protection of the S.F.R.P. review the different techniques of dosimetry used in France and Europe, and present the future orientations.The different interventions are as follow: Individual exposures of the workers: historic assessment and perspectives; medical exposure: where are the doses; legal obligations in individual dosimetry: which are the objective and the need on the subject; the dosimetry follow-up of workers by the S.I.S.E.R.I. system: assessment and perspectives; impact of the norm ISO 20553 on the follow-up of internal exposure; the implementation of the patient dose measurement in Belgium; techniques of passive dosimetry used in Europe; Supervision radiation protection at EDF: long term and short term approach; Comparison active and passive dosimetry at Melox; methodology for the choice of new neutron dosemeters; the working group M.E.D.O.R.: guide of internal dosimetry for the use of practitioners; O.E.D.I.P.E.: tool of modeling for the personalized internal dosimetry; the use of the Monte-Carlo method for the planning of the cancer treatment by radiotherapy becomes a reality; the works of the committee 2 of the ICRP; passive dosimetry versus operational dosimetry: situation in Europe; Implementation of the in vivo dosimetry in a radiotherapy department: experience of the Gustave Roussy institute; experience feedback on the in vivo measures in radiotherapy, based on the use of O.S.L. pellets; multi points O.S.L. instrumentation for the radiation dose monitoring in radiotherapy; dosimetry for extremities for medical applications: principle results of the European contract C.O.N.R.A.D.; references and perspectives in dosimetry; what perspectives for numerical dosimetry, an example: Sievert; system of dose management: how to answer to needs; the last technical evolutions in terms of electronic dosimetry in nuclear power plant; the fourth generation type reactors: what dosimetry. (N.C.)

  6. Vulva cancer

    Science.gov (United States)

    Cancer - vulva; Cancer - perineum; Cancer - vulvar; Genital warts - vulvar cancer; HPV - vulvar cancer ... cells. Other types of cancers found on the vulva are: Adenocarcinoma Basal cell carcinoma Melanoma Sarcoma Vulvar ...

  7. Colon cancer

    Science.gov (United States)

    Colorectal cancer; Cancer - colon; Rectal cancer; Cancer - rectum; Adenocarcinoma - colon; Colon - adenocarcinoma ... In the United States, colorectal cancer is one of the leading causes of deaths due to cancer. Early diagnosis can often lead to a complete cure. Almost ...

  8. Investigation of the Mechanism and Technical Implementation of Acoustic Thermography

    OpenAIRE

    Homma, Christian; Arnold, Walter

    2016-01-01

    In this thesis project, a newly developed 3D laser vibrometer system was used to demonstrate that heating of the defect-free bulk correlates with local stresses in the material and is caused by damping of the ultrasound. Two additional mechanisms that lead to crack heating were identi ed as friction and plastic deformation. The measured quadratic relationship between heating and local displacements in the specimen is explained by an additional modulation of the normal force pressing th...

  9. The implementing of inverters; Onduleurs de tension. Mise en oeuvre

    Energy Technology Data Exchange (ETDEWEB)

    Foch, H. [Ecole Nationale Superieure d' Electrotechnique, d' Electronique, d' Informatique et d' Hydraulique, Lab. d' Electrotechnique et d' Electronique Industrielle (ENSEIHT), 31 - Toulouse (France); Forest, F. [Ecole Nationale Superieure de Cachan, Lab. d' Electricite Signaux et Robotique, 94 - Cachan (France)

    2000-08-01

    The modulation technics used in the inverters control are detailed concerning their characteristics and their implementing. The main object of these modulation technics is to obtain alternative voltage waves, with adjustable amplitude and frequency without the interference harmonic components, like a filter principle. The first part deals with these type of active and passive filters. Another part is devoted to the integration of these technics in the control and regulation circuits. (A.L.B.)

  10. Screening for colorectal cancer

    DEFF Research Database (Denmark)

    Nielsen, Hans J.; Jakobsen, Karen V.; Christensen, Ib J.;

    2011-01-01

    Emerging results indicate that screening improves survival of patients with colorectal cancer. Therefore, screening programs are already implemented or are being considered for implementation in Asia, Europe and North America. At present, a great variety of screening methods are available including...... into improvements of screening for colorectal cancer includes blood-based biological markers, such as proteins, DNA and RNA in combination with various demographically and clinically parameters into a "risk assessment evaluation" (RAE) test. It is assumed that such a test may lead to higher acceptance among...... procedures for colorectal cancer. Therefore, results of present research, validating RAE tests, are awaited with interest....

  11. Technical aspects of microwave thermotherapy.

    Science.gov (United States)

    Vrba, J; Lapes, M; Oppl, L

    1999-05-01

    We describe our new technical results dealing with microwave thermotherapy (hyperthermia) in cancer treatment, see Refs. [S.B. Field, C. Franconi (Eds.), Physics and technology of hyperthermia, NATO Seminar Proceedings, Urbino, Italy, 1986; J. Hand, J.R. James (Eds.), Physical Techniques in Clinical Hyperthermia, Wiley, New York, 1986; J. Vrba, M. Lapes, Microwave Applicators for Medical Purposes, CTU Press, 1996, in Czech; J. Vrba, C. Franconi, M. Lapes, Theoretical limits for the penetration depth of the intracavitary applicators, International Journal of Hyperthermia, 12:6 (1996) 737-742; C. Franconi, J. Vrba, F. Montecchia, 27 MHz hybrid evanescent-mode applicators with flexible heating field for deep and safe subcutaneous hyperthermia, International Journal of Hyperthermia, 9:5 (1993) 655-674.]. Our research interest is to develop applicators for deep local heating and for intracavitary cancer and/or prostate treatment as well. Further, a system for 3D SAR distribution measurements in water phantom is explained. Basic evaluation of clinical results is given.

  12. Technical progress in pipeline design and construction

    Energy Technology Data Exchange (ETDEWEB)

    Hausken, K.B.

    1995-12-31

    This paper considers the technical progress in offshore pipeline construction with limitation to some general subjects covering pipeline design, installation and start-up. In future the use of limit state pipeline design philosophy, may be implemented as an alternative to the stress based design commonly used to day giving a potential for further optimisation of the pipeline design and consequently reduction of the initial investment. Comprehensive research and development efforts in Norway in the second half of the 1970`s, made it technically feasible to cross the deep water Norwegian Trench in the 1980`s. In addition, the development of several offshore pipeline systems until to day including gas distribution systems to the European continent, have brought Norway to the forefront of technical expertise

  13. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Renal Cell) Cancer Leukemia Lung Cancer Lymphoma Pancreatic Cancer Prostate Cancer Skin Cancer Thyroid Cancer Uterine Cancer All ... Cancer Biology Cancer Genomics Causes of Cancer Diagnosis Prevention Screening & Early Detection Treatment Cancer & Public Health Cancer ...

  14. Tobacco and Cancer

    Science.gov (United States)

    ... Cancer? Breast Cancer Colon/Rectum Cancer Lung Cancer Prostate Cancer Skin Cancer Show All Cancer Types News and Features Cancer Glossary ACS Bookstore Cancer Information Cancer Basics Cancer Prevention & Detection Signs & Symptoms of Cancer Treatments & Side Effects ...

  15. Stages of Prostate Cancer

    Science.gov (United States)

    ... Renal Cell) Cancer Leukemia Lung Cancer Lymphoma Pancreatic Cancer Prostate Cancer Skin Cancer Thyroid Cancer Uterine Cancer All ... Cancer Treatment Prostate Cancer Prevention Genetics of Prostate Cancer Prostate Cancer Screening Research Prostate Cancer Treatment (PDQ®)–Patient ...

  16. Implementation of a Project-Based Telecommunication Engineering Design Course

    OpenAIRE

    Ali Akbarian, Hadi; Soh, Ping Jack; Farsi, Saeed; Xu, Hantao; Van Lil, Emmanuel; Nauwelaers, Bart; Vandenbosch, Guy; Schreurs, Dominique

    2014-01-01

    This paper describes and discusses the implementation of a project-based graduate design course in Telecommunication Engineering. This course, which requires a combination of technical and softskills for its completion, enables guided independent learning (GIL) and application of technical knowledge acquired from classroom learning. Its main implementation challenge is the need for instructors to define graduate-level GIL activities which are unique for the project objectives and scope. This ...

  17. Technical standards in nuclear area

    International Nuclear Information System (INIS)

    The technical standardization in nuclear area is discussed. Also, the competence of CNEN in standardization pursuit is analysed. Moreover, the process of working up of technical standards is explained; in addition, some kinds of technical standards are discussed. (author)

  18. 1977 Bibliography of Technical Writing.

    Science.gov (United States)

    Bankston, Dorothy; And Others

    1978-01-01

    Lists bibliographies, books, reviews, and articles on technical writing; categorizes articles according to a number of topics, including pedagogy, technical style, writing abstracts and precis, writing proposals, graphic/visual aids, and the technical writing profession. (MAI)

  19. Design and Implementation of Collaborative Research Approaches

    Science.gov (United States)

    Venti, Mike W.; Berger, David E.

    2009-01-01

    This poster reviews the collarborative research approaches that NASA has been designing and implementing for the Integrated Vehicle Health Management (IVHM) Project. The inputs for the technical plan are reviewed, the Research Test and Integration Plan (RTIP) WIKI, is used to create and propose a multi-themed and multi-partner research testing opportunities. The outputs are testing opportunities.

  20. Implementing Pre-Vocational Studies in Venezuela.

    Science.gov (United States)

    Kim, Young Mi

    This paper describes prevocational education in Venezuela on each educational level. First, it sets a historical context by identifying aspects of technical education that emerged at different times in its development; then it identifies certain strategies created to support the implementation of prevocationalization, and finally it concludes by…

  1. Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Bohdan W. Oppenheim; Rudolf Marloth

    2007-10-26

    Executive Summary The document contains Final Technical Report on the Industrial Assessment Center Program at Loyola Marymount University in Los Angeles, covering the contract period of 9/1/2002 to 11/30/2006, under the contract DE-FC36-02GO 12073. The Report describes six required program tasks, as follows: TASK 1 is a summary of the assessments performed over the life of the award: 77 assessments were performed, 595 AR were recommended, covering a very broad range of manufacturing plants. TASK 2 is a description of the efforts to promote and increase the adoption of assessment recommendations and employ innovative methods to assist in accomplishing these goals. The LMU IAC has been very successful in accomplishing the program goals, including implemented savings of $5,141,895 in energy, $10,045,411 in productivity and $30,719 in waste, for a total of $15,218,025. This represents 44% of the recommended savings of $34,896,392. TASK 3 is a description of the efforts promoting the IAC Program and enhancing recruitment efforts for new clients and expanded geographic coverage. LMU IAC has been very successful recruiting new clients covering Southern California. Every year, the intended number of clients was recruited. TASK 4 describes the educational opportunities, training, and other related activities for IAC students. A total of 38 students graduated from the program, including 2-3 graduate students every semester, and the remainder undergraduate students, mostly from the Mechanical Engineering Department. The students received formal weekly training in energy (75%) and productivity (25). All students underwent extensive safety training. All students praised the IAC experience very highly. TASK 5 describes the coordination and integration of the Center activities with other Center and IAC Program activities, and DOE programs. LMU IAC worked closely with MIT, and SDSU IAC and SFSU IAC, and enthusiastically supported the SEN activities. TASK 6 describes other tasks

  2. Technical and dosimetric aspects of quality control in mammography

    International Nuclear Information System (INIS)

    Mammography is an effective method for early detection of breast cancer. Before screening programmes using mammography are implemented, a risk (financial cost)/benefit analysis has to be made and a quality-control programme for the technical and dosimetric aspects has to be adopted. This should include daily checks on the film processing and the total mammography procedure. The installation of a mAs meter is essential for daily checks and can be used for determination of the absorbed dose. Accurate determination of the tube voltage is essential with regard to absorbed dose variations. The focal spot size should be measured rather than relying on the value specified by the manufacturer. The determination of the focal charge (mAs) value for actual radiographs of female breasts combined with a measurement of the compressed breast thickness provides information on the absorbed dose values for actual radiographs. An approximately 50 mm thick poly(methyl methacrylate) phantom can be used for determination of absorbed dose in mammography. (author)

  3. The NASA Technical Report Server

    Science.gov (United States)

    Nelson, Michael L.; Gottlich, Gretchen L.; Bianco, David J.; Paulson, Sharon S.; Binkley, Robert L.; Kellogg, Yvonne D.; Beaumont, Chris J.; Schmunk, Robert B.; Kurtz, Michael J.; Accomazzi, Alberto

    1995-01-01

    The National Aeronautics and Space Act of 1958 established NASA and charged it to "provide for the widest practicable and appropriate dissemination of information concerning its activities and the results thereof." The search for innovative methods to distribute NASA's information lead a grass-roots team to create the NASA Technical Report Server (NTRS), which uses the World Wide Web and other popular Internet-based information systems as search engines. The NTRS is an inter-center effort which provides uniform access to various distributed publication servers residing on the Internet. Users have immediate desktop access to technical publications from NASA centers and institutes. The NTRS is comprised of several units, some constructed especially for inclusion in NTRS, and others that are existing NASA publication services that NTRS reuses. This paper presents the NTRS architecture, usage metrics, and the lessons learned while implementing and maintaining the service. The NTRS is largely constructed with freely available software running on existing hardware. NTRS builds upon existing hardware and software, and the resulting additional exposure for the body of literature contained ensures that NASA's institutional knowledge base will continue to receive the widest practicable and appropriate dissemination.

  4. TADS and Technical Assistance.

    Science.gov (United States)

    Trohanis, Pascal L.

    1983-01-01

    Accomplishments of the Technical Assistance Development System (TADS) are cited, current challenges (including program development, and communication and coordination) are noted, and the mission mandated for TADS is outlined. (CL)

  5. OSH technical reference manual

    Energy Technology Data Exchange (ETDEWEB)

    1993-11-01

    In an evaluation of the Department of Energy (DOE) Occupational Safety and Health programs for government-owned contractor-operated (GOCO) activities, the Department of Labor`s Occupational Safety and Health Administration (OSHA) recommended a technical information exchange program. The intent was to share written safety and health programs, plans, training manuals, and materials within the entire DOE community. The OSH Technical Reference (OTR) helps support the secretary`s response to the OSHA finding by providing a one-stop resource and referral for technical information that relates to safe operations and practice. It also serves as a technical information exchange tool to reference DOE-wide materials pertinent to specific safety topics and, with some modification, as a training aid. The OTR bridges the gap between general safety documents and very specific requirements documents. It is tailored to the DOE community and incorporates DOE field experience.

  6. DEPLETED URANIUM TECHNICAL WORK

    Science.gov (United States)

    The Depleted Uranium Technical Work is designed to convey available information and knowledge about depleted uranium to EPA Remedial Project Managers, On-Scene Coordinators, contractors, and other Agency managers involved with the remediation of sites contaminated with this mater...

  7. NCDC Technical Reports

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCDC Technical Reports is a set of retrospective analyses produced by the Research Customer Service Group and the National Climatic Data Center from 1995 to 2008....

  8. Superfund Technical Assistance Grants

    Data.gov (United States)

    U.S. Environmental Protection Agency — This asset includes data related to the Superfund Technical Assistance Grant program, including grant number, award amounts, award dates, period of performance,...

  9. Technical report writing today

    CERN Document Server

    Riordan, Daniel G

    2014-01-01

    "Technical Report Writing Today" provides thorough coverage of technical writing basics, techniques, and applications. Through a practical focus with varied examples and exercises, students internalize the skills necessary to produce clear and effective documents and reports. Project worksheets help students organize their thoughts and prepare for assignments, and focus boxes highlight key information and recent developments in technical communication. Extensive individual and collaborative exercises expose students to different kinds of technical writing problems and solutions. Annotated student examples - more than 100 in all - illustrate different writing styles and approaches to problems. Numerous short and long examples throughout the text demonstrate solutions for handling writing assignments in current career situations. The four-color artwork in the chapter on creating visuals keeps pace with contemporary workplace capabilities. The Tenth Edition offers the latest information on using electronic resum...

  10. Eclipse Platform Technical Overview

    OpenAIRE

    ALS-NSCORT,

    2003-01-01

    The Eclipse Platform is designed for building integrated development environments (IDEs) that can be used to create applications as diverse as web sites, embedded JavaTM programs, C++ programs, and Enterprise JavaBeansTM. This paper is a general technical introduction to the Eclipse Platform. Part I presents a technical overview of its architecture. Part II is a case study of how the Eclipse Platform was used to build a full-featured Java development environment. 20 pages Provider Notes...

  11. The role of cancer registries in cancer control.

    Science.gov (United States)

    Parkin, Donald Maxwell

    2008-04-01

    Cancer control aims to reduce the incidence, morbidity, and mortality of cancer and to improve the quality of life of cancer patients through the systematic implementation of evidence-based interventions in prevention, early diagnosis, treatment, and palliative care. In the context of a national cancer control program (NCCP), a cancer surveillance program (CSP), built around a population-based cancer registry, is an essential element. Data on the size and evolution of the cancer burden in the population are essential to evaluation of the current situation, to setting objectives for cancer control, and defining priorities. Cancer data are essential in monitoring the progress of the implementation of an NCCP, as well as providing an evaluation of the many individual cancer control activities. In the context of an NCCP, the CSP should provide a focus of epidemiological expertise, not only for providing statistical data on incidence, mortality, stage distribution, treatment patterns, and survival but also for conducting studies into the important causes of cancer in the local situation, and for providing information about the prevalence of exposure to these factors in the population. Cancer surveillance via the population-based registry therefore plays a crucial role in formulating cancer control plans, as well as in monitoring their success. PMID:18463952

  12. Technical co-operation report for 2002. Report by the Director General

    International Nuclear Information System (INIS)

    developmental impact. The development of Country Programme Frameworks (CPFs) progressed further in 2002, with new CPFs concluded or at an advanced stage of preparation for 29 more Member States. Thematic plans were prepared for food irradiation, river basin management and the role of isotopic techniques in the control of communicable diseases. The Agency increased its involvement in international efforts to promote development through intensified consultation and collaboration with the United Nations system, multilateral banks, regional organizations and other relevant bodies. As part of its activities to develop strategic partnerships, the Agency signed Memoranda of Understanding with the Common Fund for Commodities, the Transplant Procurement Management Project (University of Barcelona), the National Atomic Energy Agency of Argentina and the University of Buenos Aires. A new form of partnership was entered with the Nuclear Threat Initiative to support the decommissioning of a research reactor in Serbia and Montenegro. In addition, contacts were strengthened between the Agency and regional development organizations to ensure that policies for development programmes complement each other. During 2002, achievements were made in many areas of implementation of the technical co-operation programme. Training events, expert missions and equipment procurement supported national and regional efforts to initiate or improve cancer therapy facilities. Different government nutrition supplementation programmes benefited from Agency expertise to verify they had the impact expected. In the area of water resource management, an ongoing regional project brought together more than 30 water institutes to solve water shortage problems. And in several regions, plans to construct mass- rearing facilities for medfly and tsetse were a testament that national and regional authorities are committed to the sterile insect technique for the control of insect pests. In response to resolution GC(46)/RES/10

  13. Implementing ‘Site BIM’

    DEFF Research Database (Denmark)

    Davies, Richard; Harty, Chris

    2013-01-01

    of an innovative ‘Site BIM’ system on a major hospital construction project. The main contractor on the project developed BIM-enabled tools to allow site workers using mobile tablet personal computers to access design information and to capture work quality and progress data on-site. Accounts show that ‘Site BIM......Numerous Building Information Modelling (BIM) tools are well established and potentially beneficial in certain uses. However, issues of adoption and implementation persist, particularly for on-site use of BIM tools in the construction phase. We describe an empirical case-study of the implementation......’, while judged to be successful and actively supporting users, was delivered through an exploratory and emergent development process of informal prototyping. Technical IT skills were adopted into the construction project through personal relationships and arrangements rather than formal processes...

  14. TRUPACT-1 implementation plan

    Energy Technology Data Exchange (ETDEWEB)

    Hurley, J.D.; Tappen, J.J. (Westinghouse Electric Corp., Albuquerque, NM (United States). Joint Integration Office); Christensen, D.S. (USDOE Joint Integration Office, Albuquerque, NM (United States)) (eds.)

    1985-09-01

    TRUPACT-1, the TRansUranic PACkage Transporter is a packaging designed to transport defense contact handled transuranic (CH-TRU) waste from generating and interim TRU waste storage facilities to the Waste Isolation Pilot Plant (WIPP). Prior to fabrication and procurement of a full fleet, an initial design (TRUPACT-1) will be introduced to the defense TRU waste complex through use in an operational prototype fleet which will consist of Units 1, 2, and 3. In an effort to provide a relatively smooth introduction of the TRUPACT-1, the TRUPACT Technical Team (TTT) has developed the following implementation plan. The plan provides detailed information on user handling opportunities, schedules, equipment, responsibilities, reporting and data collection activities to be performed. The intent of this document is to provide users of the TRUPACT-1 with a guidance document, complete with references, that will allow the smooth introduction of this new transportation system by providing the information necessary for collecting operational, performance and cost data. These data will be used in modeling and full fleet design and procurement activities. In addition, these data will help fine tune procedures in the inspection and maintenance document and the operational document. Additional objectives of this plan are to aid in the establishment of site operational, inspection and maintenance procedures as well as training of site operators and briefing state and local officials.

  15. Oral Cancer

    Science.gov (United States)

    ... TMJ Disorders Oral Cancer Dry Mouth Burning Mouth Tooth Decay See All Oral Complications of Systemic Diseases Cancer ... Puts Someone at Risk? Possible Signs & Symptoms Early Detection About Oral Cancer Oral cancer includes cancers of ...

  16. Cancer and environment

    Energy Technology Data Exchange (ETDEWEB)

    Meerkamp van Embden, I.C.

    1980-01-01

    The author comes to the following conclusions: cancerous diseases, if occurring as a result of chemical-dependent expositions at work, are diminished by continual improvements of medical-technical industrial safety measures. An increasing cancer risk by chemical products must be denied. The statements on a generally excessive content of carcinogeneous residues in food do not bear a critical examination either. The former endangering rate of men by carcinogens, partly of natural, partly of anthropogeneous origin, had been at least as high and frequently also much higher than it is today. Within the past 15 years comprehensive measures of technical-hygienic pollution protection have relieved the emission of pollutants. Now as before the general life expectance is increasing. While the age-adjusted cancer mortality rate has remained practically unchanged during the past decades the number deaths caused by heart and circulation diseases shows an alarming rise, also when age-adjusted. The way of living plays an important part as to cancer, apart from the status of immunity and age-dependent processes. An environmental factor for cancer risks which is frequently underestimated is excessive insolation. The importance of psychosocial risk factors has not yet been investigated sufficiently although it may be just them which could be important for the assessment of cancer hazards.

  17. Optimal breast cancer pathology manifesto.

    Science.gov (United States)

    Tot, T; Viale, G; Rutgers, E; Bergsten-Nordström, E; Costa, A

    2015-11-01

    This manifesto was prepared by a European Breast Cancer (EBC) Council working group and launched at the European Breast Cancer Conference in Glasgow on 20 March 2014. It sets out optimal technical and organisational requirements for a breast cancer pathology service, in the light of concerns about variability and lack of patient-centred focus. It is not a guideline about how pathology services should be performed. It is a call for all in the cancer community--pathologists, oncologists, patient advocates, health administrators and policymakers--to check that services are available that serve the needs of patients in a high quality, timely way.

  18. Implementation of a management system for operating organizations of research reactors

    Energy Technology Data Exchange (ETDEWEB)

    Kibrit, Eduardo, E-mail: kibrit@ctmsp.mar.mil.b [Centro Tecnologico da Marinha em Sao Paulo (CTMSP), Sao Paulo, SP (Brazil); Aquino, Afonso Rodrigues de; Zouain, Desiree Moraes, E-mail: araquino@ipen.b, E-mail: dmzouain@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    This paper presents the requirements established by an IAEA draft technical document for the implementation of a management system for operating organisations of research reactors. The following aspects will be discussed: structure of IAEA draft technical document, management system requirements, processes common to all research reactors, aspects for the implementation of the management system, and a formula for grading the management system requirements. (author)

  19. Quality and Profitability improvement by Technical Audit

    Directory of Open Access Journals (Sweden)

    Prof. Srivastava S. B.

    2009-10-01

    Full Text Available This paper is aimed for finding the Quality and Profitability Improvement by Technical Audit, through a case study and further establishing the relationship between the product quality, profitability and technical audit. Quality audit generates the report of non conformance which basically represents the deviation from committed quality of products, or in short, it may be called as postmortem of product quality. By virtue of quality audit, the commitment, implementation and follow up for product quality are aligned. This delivers a good quality of product to the customers and thus the customer is benefited. In industries, Quality Inspectors are giving their decision for quality of product in two categories, "ACCEPTED" or "REJECTED". The accepted products are coming to the customers and the rejected products become the burden / problem to the manufacturers.If accepted product quantity is within the “NORMS”, no one cares regarding the rejected product quantities, what so ever. When the rejected product quantity increases beyond the “NORMS”, the analysis process starts to find out the reasons of rejections. Sometimes, it becomes too late to search out the reasons of rejections and survival of the industry becomes a problem. By technical audit and audit report implementation such type of conditions can be avoided and controlled.Basically, Quality is the function of Man, Machine, Materials, Methods, Movement, Manufacturing Processes, Monitoring and Management (8 M’s. If the technicality of 8 M’s is corrected by Technical Audit, the product quality will improve automatically and the profitability of the organization will improve. In short it can be solicited that if 8 M’s are all right, the product quality and profitability will automatically be set right. This may become an important aspect in the scenario of Indian Industries. The findings are supported by a case study of a Process Plant (Slag Dryer of a reputed Indian Industry.

  20. Rationale, design, and implementation protocol of the Dutch clinical practice guideline Pain in patients with cancer: a cluster randomised controlled trial with short message service (SMS) and interactive voice response (IVR).

    NARCIS (Netherlands)

    Boveldt, N.D. te; Engels, Y.M.P.; Besse, K.; Vissers, K.C.P.; Vernooij-Dassen, M.J.F.J.

    2011-01-01

    ABSTRACT: BACKGROUND: One-half of patients with cancer have pain. In nearly one out of two cancer patients with pain, this was undertreated. Inadequate pain control still remains an important problem in this group of patients. Therefore, in 2008 a national, evidence-based multidisciplinary clinical

  1. Some experiences of implementing TQM in higher education in Denmark

    DEFF Research Database (Denmark)

    Dahlgaard, Jens Jørn; Madsen, Ole Nørgaard

    1999-01-01

    The paper deals with Danish experiences of implementing TQM in Higher Education. The conclusions from an international seminar on quality management in education (1993) became the catalyst of a research project on implementing Total Quality Management (TQM) at a technical college. The European...

  2. 6 Common Cancers - Breast Cancer

    Science.gov (United States)

    ... Home Current Issue Past Issues 6 Common Cancers - Breast Cancer Past Issues / Spring 2007 Table of Contents For ... slow her down. Photo: AP Photo/Brett Flashnick Breast Cancer Breast cancer is a malignant (cancerous) growth that ...

  3. Joint implementation: A phased approach

    Energy Technology Data Exchange (ETDEWEB)

    Vellinga, P.; Heintz, R. [Vrije Universiteit, Amsterdam (Netherlands)

    1995-11-01

    What is Joint Implementation (JI)? In the Framework Convention on Climate Change (FCCC) it is described as a mechanism for cooperation between parties to meet the objective of the convention. Important considerations in favor of the introduction of the concept of JI are: (1) JI schemes could stimulate development and technology cooperation through generating (often private company) resources that would otherwise not be mobilized for such purposes, and thus stimulate broader participation in abatement measures. (2) The financial and societal cost for greenhouse gas abatement measures varies strongly among the parties to the FCCC. Given the global nature of the problem, national boundaries should not be barriers for the identification and implementation of cost effective schemes. Important reservations with regard to the introduction of the concept are: (1) The mechanism could be used by the developed countries to buy their way out of their obligation to take the lead in combating climate change. Ironically, JI could have the effect that the poorer countries with relatively low marginal costs for limiting emissions or enhancing sinks would be sponsored to adjust their pattern of development, while emissions in the richer countries would continue to grow. (2) At present, there exists considerable uncertainties with respect to a number of technical matters, such as measuring the net environmental effect of a JI project. However, these technical problems can probably be solved in due course (along with the findings of the IPCC and experiences gained with JI).

  4. Software configuration management plan for the Hanford site technical database

    Energy Technology Data Exchange (ETDEWEB)

    GRAVES, N.J.

    1999-05-10

    The Hanford Site Technical Database (HSTD) is used as the repository/source for the technical requirements baseline and programmatic data input via the Hanford Site and major Hanford Project Systems Engineering (SE) activities. The Hanford Site SE effort has created an integrated technical baseline for the Hanford Site that supports SE processes at the Site and project levels which is captured in the HSTD. The HSTD has been implemented in Ascent Logic Corporation (ALC) Commercial Off-The-Shelf (COTS) package referred to as the Requirements Driven Design (RDD) software. This Software Configuration Management Plan (SCMP) provides a process and means to control and manage software upgrades to the HSTD system.

  5. Technical training - places available

    CERN Multimedia

    2012-01-01

    If you would like more information on a course, or for any other inquiry/suggestions, please contact Technical.Training@cern.ch Valeria Perez Reale, Learning Specialist, Technical Programme Coordinator (Tel.: 62424) Eva Stern and Elise Romero, Technical Training Administration (Tel.: 74924) HR Department »Electronics design Next Session Duration Language Availability Comprehensive VHDL for FPGA Design 08-Oct-12 to 12-Oct-12 5 days English 3 places available Foundations of Electromagnetism and Magnet Design (EMAG) 14-Nov-12 to 27-Nov-12 6 days English 20 places available Impacts de la suppression du plomb (RoHS) en électronique 26-Oct-12 to 26-Oct-12 8 hours French 15 places available Introduction to VHDL 10-Oct-12 to 11-Oct-12 2 days English 7 places available LabVIEW Real Time and FPGA 13-Nov-12 to 16-Nov-12 5 days French 5 places available »Mechanical design Next Se...

  6. Technical training: places available

    CERN Multimedia

    2013-01-01

    If you would like more information on a course, or for any other inquiry/suggestions, please contact Technical.Training@cern.ch Valeria Perez Reale, Learning Specialist, Technical Programme Coordinator (Tel.: 62424) Eva Stern and Elise Romero, Technical Training Administration (Tel.: 74924)   Electronics design Next Session Duration Language Introduction to VHDL 21-Feb-13 to 22-Feb-13 2 days English Mechanical design Next Session Duration Language ANSYS - Introduction à ANSYS Mechanical APDL 04-Feb-13 to 07-Feb-13 4 days English Applications de la cotation fonctionnelle et du langage ISO 06-Feb-13 to 08-Feb-13 2 days 4 hours French CATIA V5 – Surfacique 14-Jan-13 to 15-Jan-13 2 days French Office software Next Session Duration Language ACCESS 2010 - niveau 2 : ECDL 06-Feb-13 to 07-Feb-13 2 days French Dreamweaver CS3 - Niveau 1 14-Jan-13 to 15-Jan-13 2 d...

  7. Technical training - Places available

    CERN Multimedia

    2012-01-01

    If you would like more information on a course, or for any other inquiry/suggestions, please contact Technical.Training@cern.ch Valeria Perez Reale, Learning Specialist, Technical Programme Coordinator (Tel.: 62424) Eva Stern and Elise Romero, Technical Training Administration (Tel.: 74924)   Electronics design Next Session Duration Language Availability Certified LabVIEW Associate Developer (CLAD) 06-Dec-12 to 06-Dec-12 1 hour English One more place available Compatibilité électromagnetique (CEM): Applications 23-Nov-12 to 23-Nov-12 3.5 hours English 3 places available Compatibilité électromagnétique (CEM): Introduction 23-Nov-12 to 23-Nov-12 3 hours English 43 places available Effets des Radiations sur les composants et systèmes électroniques 11-Dec-12 to 12-Dec-12 1 day 4 hours French 9 places available LabVIEW for beginners ...

  8. Fuel Element Technical Manual

    Energy Technology Data Exchange (ETDEWEB)

    Burley, H.H. [ed.

    1956-08-01

    It is the purpose of the Fuel Element Technical Manual to Provide a single document describing the fabrication processes used in the manufacture of the fuel element as well as the technical bases for these processes. The manual will be instrumental in the indoctrination of personnel new to the field and will provide a single data reference for all personnel involved in the design or manufacture of the fuel element. The material contained in this manual was assembled by members of the Engineering Department and the Manufacturing Department at the Hanford Atomic Products Operation between the dates October, 1955 and June, 1956. Arrangement of the manual. The manual is divided into six parts: Part I--introduction; Part II--technical bases; Part III--process; Part IV--plant and equipment; Part V--process control and improvement; and VI--safety.

  9. CERN Technical Training : Vista !

    CERN Multimedia

    HR Department

    2008-01-01

    You are running Vista on your new PC – or are planning to install it? The Technical Training service is organizing a half-day training course on the new features of the VISTA operating system. This course introduces the new interfaces and presents the new functionalities for people who are experienced in the use of Windows XP. The next bilingual sessions of this course will take place on 12 December 2008 and 30 January 2009. Register using our catalogue: http://cta.cern.ch/cta2/f?p=110:9 or contact us with your questions/comments at mailto:Technical.Training@cern.ch

  10. CERN Technical Training : Vista !

    CERN Multimedia

    HR Department

    2009-01-01

    Are you running Vista on your new PC – or are you planning to install it? The Technical Training service is organizing a half-day training course on the new features of the VISTA operating system. This course introduces the new interfaces and presents the new functionalities for people who are experienced in the use of Windows XP. The next bilingual session of this course will take place on 30 January 2009. Register using our catalogue: http://cta.cern.ch/cta2/f?p=110:9 or contact us with your questions/comments at mailto:Technical.Training@cern.ch

  11. CERN Technical Training : Vista !

    CERN Multimedia

    HR Department

    2008-01-01

    You are running Vista on your new PC – or are planning to install it? The Technical Training service is organizing a half-day training on the new features of the VISTA operating system. This course introduces the new interfaces and presents the new functionalities for people who are experienced using Windows XP. The next bilingual sessions of this course will take place on December 12, 2008 and January 30, 2009. Register using our catalogue : http://cta.cern.ch/cta2/f?p=110:9 or contact us with your questions/comments at Technical.Training@cern.ch

  12. CERN Technical Training : Vista !

    CERN Multimedia

    HR Department

    2008-01-01

    Are you running Vista on your new PC – or are you planning to install it? The Technical Training service is organizing a half-day training course on the new features of the VISTA operating system. This course introduces the new interfaces and presents the new functionalities for people who are experienced in the use of Windows XP. The next bilingual sessions of this course will take place on 12 December 2008 and 30 January 2009. Register using our catalogue: http://cta.cern.ch/cta2/f?p=110:9 or contact us with your questions/comments at mailto:Technical.Training@cern.ch

  13. CERN Technical Training : Vista !

    CERN Multimedia

    HR Department

    2008-01-01

    Are you running Vista on your new PC – or are planning to install it? The Technical Training service is organizing a half-day training course on the new features of the VISTA operating system. This course introduces the new interfaces and presents the new functionalities for people who are experienced in the use of Windows XP. The next bilingual sessions of this course will take place on 12 December 2008 and 30 January 2009. Register using our catalogue: http://cta.cern.ch/cta2/f?p=110:9 or contact us with your questions/comments at Technical.Training@cern.ch

  14. The Activities and Impact of State Programs to Address Hereditary Breast and Ovarian Cancer, 2011–2014

    Directory of Open Access Journals (Sweden)

    Katrina F. Trivers

    2015-10-01

    Full Text Available In 2011, the Division of Cancer Prevention and Control (DCPC, at the United States Centers for Disease Control and Prevention (CDC, released a three-year funding opportunity announcement (FOA for a competitive, non-research cooperative agreement. The agreement enhanced the capacities of state health departments to promote the application of best practices for evidence-based breast cancer genomics through education, surveillance, and policy activities. The FOA required that applicants focus on activities related to hereditary breast and ovarian cancer (HBOC. The DCPC funded three states: Georgia, Michigan, and Oregon. Georgia was a first-time recipient of cancer genomics funding, whereas Michigan and Oregon had long standing activities in cancer genomics and had received CDC funding in the past. By the end of the funding period, each state had well-functioning and impactful state-based programs in breast cancer genomics. This article highlights the impact of a few key state activities by using CDC’s Science Impact Framework. There were challenges to implementing public health genomics programs, including the need to develop relevant partnerships, the highly technical nature of the subject matter, a lack of genetic services in certain areas, and the difficulty in funding genetic services. Georgia, Michigan, and Oregon have served as models for others interested in initiating or expanding cancer genomics programs, and they helped to determine what works well for promoting and integrating public health genomics into existing systems.

  15. 1994 DOE Technical Standards Program Workshop: Proceedings

    International Nuclear Information System (INIS)

    The DOE Technical Standards Program has been structured to provide guidance and assistance for the development, adoption, and use of voluntary standards within the Department. OMB Circular A-119, ''Federal Participation in the Development and Use of Voluntary Standards'' establishes the policy to be followed in working with voluntary standards bodies, and in adopting and using voluntary standards whenever feasible. The DOE Technical Standards Program is consistent with this policy and is dedicated to the task of promoting its implementation. The theme of this year's workshop is ''Standards Initiatives in Environmental Management fostering the development and use of industry standards for safe, environmentally responsible operations.'' The objective of the workshop is to increase the participant's awareness of the standardization activities taking place nationally and internationally and the impact of these activities on their efforts, and to facilitate the exchange of experiences, processes, and tools for implementing the program. Workshop sessions will include presentations by industry and Government notables in the environment, safety, and health arena with ample opportunity for everyone to ask questions and share experiences. There will be a breakout session which will concentrate on resolution of issues arising from the implementation of the DOE Technical Standards Program and a plenary session to discuss the plans developed by the breakout groups. Many organizations provide services and products which support the development, processing, distribution, and retrieval of standards. Those organizations listed at the end of the agenda will have exhibits available for your perusal throughout the workshop. Last year's workshop was very successful in stimulating an understanding of an interest in the standards program. This year, we hope to build on that success and provide an environment for the synergism of ideas to enhance the program and advance its implementation

  16. Conversion of NEK standard technical specifications into improved technical specifications

    International Nuclear Information System (INIS)

    also two bigger processes that need to be finished and fully applied: training to use ITS and implementation of document changes at plant (USAR, procedures, programs, Technical Requirement Manual - TRM etc.) which are time and man-power consuming processes. (author)

  17. Potential for low fracture toughness and lamellar tearing on PWR steam generator and reactor coolant pump supports. Resolution of generic technical activity A-12

    International Nuclear Information System (INIS)

    This report summarizes work performed by the Nuclear Regulatory Commission staff and its contractor, Sandia Laboratories, in the resolution of Generic Technical Activity A-12, ''Potential for Low Fracture Toughness and Lamellar Tearing in PWR Steam Generator and Reactor Coolant Pump Supports.'' The report describes the technical issues, the technical studies performed by Sandia describes the technical issues, the technical studies performed by Sandia Laboratories, the NRC staff's technical positions based on these studies, and the staff's plan for implementing its technical positions. It also provides recommendations for further work. The complete technical input from Sandia Laboratories is appended to the report

  18. Cancer Statistics: Pancreas Cancer

    Science.gov (United States)

    ... qnad9A-rfcw?rel=0 SEER Stat Fact Sheets: Pancreas Cancer Expand All Collapse All Statistics at a ... 5 Years Or More after Being Diagnosed with Pancreas Cancer? Relative survival statistics compare the survival of ...

  19. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Types Recurrent Cancer Common Cancer Types Bladder Cancer Breast Cancer Colorectal Cancer Kidney (Renal Cell) Cancer Leukemia Lung ... Biology Cancer Genomics Causes of Cancer Diagnosis Prevention Screening & Early Detection Treatment Cancer & Public Health Cancer Health ...

  20. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Treatment Pediatric Supportive Care Unusual Cancers of Childhood Treatment Research Metastatic Cancer Metastatic Cancer Research Common Cancer Types Recurrent Cancer Common Cancer Types Bladder Cancer Breast Cancer Colorectal Cancer Kidney (Renal Cell) Cancer Leukemia ...

  1. Teaching Technical Report Writing

    Science.gov (United States)

    De Pasquale, Joseph A.

    1977-01-01

    A high school electronics teacher describes the integration of technical report writing in the electronics program for trade and industrial students. He notes that the report writing rather than just recording data seemed to improve student laboratory experience but further improvements in the program are needed. A sample lab report is included.…

  2. Teaching Technical Writing.

    Science.gov (United States)

    Lummis, Jean

    2001-01-01

    Uses concept-based laboratory reports to incorporate technical writing into teaching. Features three paragraphs in the writing format: introductory paragraph, data paragraph, and conclusion. Recommends using this teaching method, especially in chemistry laboratories, because of the difficulties students have in understanding. (YDS)

  3. CATV Technical Papers.

    Science.gov (United States)

    National Cable Television Association, Inc., Washington, DC.

    Complete technical papers of the 1977 National Cable Television Association Convention are included in this report. Twenty-two of 32 papers and two abstracts cover the topics of advanced cable television techniques, human reactions to television picture impairment, special displays and services, protection from theft of service, everyday…

  4. Review of technical specifications

    International Nuclear Information System (INIS)

    The present paper deals with position and function of technical specifications before and during the manufacturing of reactor components, their structure and reasons for specific regulations due to safety philosophy and explains the cooperation of supplier, manufacturer, utilities and supervisory organizations. (RW)

  5. ICCS 2009 Technical Report

    Science.gov (United States)

    Schulz, Wolfram, Ed.; Ainley, John, Ed.; Fraillon, Julian, Ed.

    2011-01-01

    This report is structured so as to provide technical detail about each aspect of International Civic and Citizenship Education Study (ICCS). The overview is followed by a series of chapters that provide detail about different aspects of ICCS. Chapters, 2, 3, 4, and 5 are concerned with the instruments. Chapter 2 provides information about the…

  6. Technical Training: Places available

    CERN Multimedia

    Monique Duval

    2005-01-01

    The number of places available may vary. Please check our Web site to find out the current availability. Places are available on the following courses: LabVIEW Real-Time (F) : 7 - 9.6.2005 (3 jours) LabVIEW Migration 6 to 7: 14.6.2005 (1 day) IT3T/1 - Read your mail and more with Outlook 2003 : 14.6.2005 (IT Technical Training Tutorial, free of charge) IT3T/2 - Creating, managing and using distribution lists with Simba2 : 16.6.2005 (IT Technical Training Tutorial, free of charge) FrontPage 2003 - niveau 2 : 16 & 17.6.2005 (2 jours) Utilisation de fichiers PDF avec ACROBAT 6.0 : 20.6.2005 (1journée) Introduction to ANSYS: 21 - 24.6.2005 (4 days) IT3T/3 - Working remotely with Windows XP : 28.6.2005 (IT Technical Training Tutorial, free of charge) IT3T/4 - Editing Websites with Frontpage 2003 : 30.6.2005 (IT Technical Training Tutorial, free of charge) WORD 2003 (Short Course I) - HowTo... Work with repetitive tasks /AutoText, AutoFormat, AutoC...

  7. Routledge French technical dictionary

    CERN Document Server

    1994-01-01

    The French-English volume of this highly acclaimed set consists of some 100,000 keywords in both French and English, drawn from the whole range of modern applied science and technical terminology. Covers over 70 subject areas, from engineering and chemistry to packaging, transportation, data processing and much more.

  8. Transformation of technical infrastructure

    DEFF Research Database (Denmark)

    Nielsen, Susanne Balslev

    The scope of the project is to investigate the possibillities of - and the barriers for a transformation of technical infrastructure conserning energy, water and waste. It focus on urban ecology as a transformation strategy. The theoretical background of the project is theories about infrastructure...... on sustainable sewage management....

  9. Materials Technical Team Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2013-08-01

    Roadmap identifying the efforts of the Materials Technical Team (MTT) to focus primarily on reducing the mass of structural systems such as the body and chassis in light-duty vehicles (including passenger cars and light trucks) which enables improved vehicle efficiency regardless of the vehicle size or propulsion system employed.

  10. Technical memory 1999

    International Nuclear Information System (INIS)

    The technical memory 1999 of the Nuclear Regulatory Authority (NRA) of the Argentine Republic, compile the papers published in the subject on radiation protection and nuclear safety, safeguards and physical protection, and presented in congress or meetings of these specialities by personnel of the mentioned institution during 1999

  11. Technical objectives of inspection

    International Nuclear Information System (INIS)

    The various technical objectives of inspection are discussed in a very general manner. The discussion includes how the inspection function is related to the assumed threat, the various degrees of assurance and reliance on criteria, and the hierarchy of assurance which is obtained from the various types or levels of inspection

  12. Technical Training: Places available

    CERN Multimedia

    Monique Duval

    2005-01-01

    The number of places available may vary. Please check our Web site to find out the current availability. Places are available on the following courses: LabVIEW Migration 6 to 7: 14.6.2005 (1 day) IT3T/1 - Read your mail and more with Outlook 2003 : 14.6.2005 (IT Technical Training Tutorial, free of charge) IT3T/2 - Creating, managing and using distribution lists with Simba2 : 16.6.2005 (IT Technical Training Tutorial, free of charge) FrontPage 2003 - niveau 2 : 16 & 17.6.2005 (2 jours) size="2">(1journée) Hands-on Introduction to Python Programming: 28 - 30.6.2005 (3 days) Introduction to ANSYS: 21 - 24.6.2005 (4 days) IT3T/3 - Working remotely with Windows XP: 28.6.2005 (IT Technical Training Tutorial, free of charge) IT3T/4 - Editing Websites with Frontpage 2003: 30.6.2005 (IT Technical Training Tutorial, free of charge) LabVIEW base 1 : 4 - 6.7.2005 (3 jours) LabVIEW Basics 2: AutoCorrect, Find/Replace) : 4.7.2005 (afternoon) WORD 2003 (Shor...

  13. ITER EDA technical activities

    International Nuclear Information System (INIS)

    Six years of technical work under the ITER EDA Agreement have resulted in a design which constitutes a complete description of the ITER device and of its auxiliary systems and facilities. The ITER Council commented that the Final Design Report provides the first comprehensive design of a fusion reactor based on well established physics and technology

  14. The French Technical Vaccination Committee (CTV).

    Science.gov (United States)

    Floret, Daniel; Deutsch, Paule

    2010-04-19

    This article describes the make-up and activities of the Technical Vaccination Committee (CTV) that serves as the National Immunization Technical Advisory Group (NITAG) in France. Comprised of a variety of technical experts, the CTV makes recommendations concerning vaccination. The committee functions as an independent expert advisory committee, and its proceedings are confidential, although its recommendations are made public. It helps to make decisions about using new vaccines, as well as re-examining guidelines for vaccines already in use. It obtains technical expertise from a variety of sources, including specialized national centres. Although it is not obliged to do so, in most cases, the French government implements CTV recommendations. Information regarding CTV activities is disseminated through publications, its website, and letters to health officials. Efforts need to be enhanced in order to avoid creating a gap between the issuing of complex vaccination policies and their understanding by general practitioners who are responsible for the administration of over 80% of all vaccines. PMID:20412996

  15. FGRAAL: Technical documentation

    Science.gov (United States)

    Mesztenyi, C. K.; Breitenlohner, H.; Yeh, J. C.

    1972-01-01

    Implementation of FGRAAL, a FORTRAN-extended graph algorithmic language for the Univac 1108 is described. The report contains the description of the implemented data structures for sets, lists and graphs. It summarizes the changes made for the RALPH compiler to accommodate the special statements of FGRAAL; gives the calling sequences generated by the changed compiler; and describes the object time subroutine package.

  16. IART® (Intra-Operative Avidination for Radionuclide Therapy) for accelerated radiotherapy in breast cancer patients. Technical aspects and preliminary results of a phase II study with 90Y-labelled biotin

    OpenAIRE

    Paganelli, G.; De Cicco, C; M. E. Ferrari; McVie, G.; Pagani, G; Leonardi, M C; Cremonesi, M.; Ferrari, A.; Pacifici, M.; Di Dia, A; Botta, F; De Santis, R; Galimberti, V.; Luini, A.; Orecchia, R.

    2010-01-01

    Background: Breast conserving surgery (BCS) plus external beam radiotherapy (EBRT) is considered the standard treatment for early breast cancer. We have investigated the possibility of irradiating the residual gland, using an innovative nuclear medicine approach named IART® (Intra-operative Avidination for Radionuclide Therapy). Aim: The objective of this study was to determine the optimal dose of avidin with a fixed activity (3.7 GBq) of 90Y-biotin, in order to provide a boost of 20 Gy, foll...

  17. Global challenges of implementing human papillomavirus vaccines

    Directory of Open Access Journals (Sweden)

    Mishra Amrita

    2011-06-01

    Full Text Available Abstract Human Papillomavirus vaccines are widely hailed as a sweeping pharmaceutical innovation for the universal benefit of all women. The implementation of the vaccines, however, is far from universal or equitable. Socio-economically marginalized women in emerging and developing, and many advanced economies alike, suffer a disproportionately large burden of cervical cancer. Despite the marketing of Human Papillomavirus vaccines as the solution to cervical cancer, the market authorization (licensing of the vaccines has not translated into universal equitable access. Vaccine implementation for vulnerable girls and women faces multiple barriers that include high vaccine costs, inadequate delivery infrastructure, and lack of community engagement to generate awareness about cervical cancer and early screening tools. For Human Papillomavirus vaccines to work as a public health solution, the quality-assured delivery of cheaper vaccines must be integrated with strengthened capacity for community-based health education and screening.

  18. 1998 federal technical standards workshop: Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-10-01

    The theme for the 1998 workshop was Standards Management -- A World of Change and Opportunities. The workshop`s goal was to further the implementation of the National Technology Transfer and Advancement Act of 1995 (Public Law 104-113) through the sharing of standards management success stories, lessons learned, and emerging initiatives within the Executive Branch of the Federal Government. The target audience for this workshop included agency/department and contractor personnel and representatives of standards developing organizations that either used technical standards in their work for the Federal Government of participated in standards writing/management activities in support of the missions and programs of Federal agencies/departments. As with previous standards workshops sponsored by the DOE, views on the technical subject areas under the workshop theme were solicited from and provided by agency Standards Executives and standards program managers, voluntary standards organizations, and the private sector. This report includes vugraphs of the presentations.

  19. Involving technical professionals in community relations

    International Nuclear Information System (INIS)

    The Weldon Spring site Remedial Action Project (WSSRAP), a U.S. Department of Energy (DOE) environmental restoration project, has developed a successful community relations program that differs from the traditional approach and has built a general consensus about the DOE's work at the Weldon Spring site. The WSSRAP has a small, dedicated Community Relations Department that is heavily supported by technical professionals who receive intensive training in preparatory and presentation skills, role-playing, and critiquing of performances. This training allows the public to speak directly with the individuals responsible for remediation activities. The media, in turn, has access to technical individuals with good presentation skills, and WSSRAP managers can be confident that interactions are handled professionally. This approach results in a satisfied client. The WSSRAP's community relations program is a high-quality, cost-effective program that could be easily implemented by other facilities

  20. Experience of international projects implementation at Leningrad Nuclear Power Plant

    Energy Technology Data Exchange (ETDEWEB)

    Zavialov, L.A. [Leningrad Nuclear Power Plant ' Rosenergoatom' , Leningrad Region, 188540, Sosnovy Bor (Russian Federation)

    2008-07-01

    During the period of 1992-2007 more than 60 different projects of different specificity and budget have been successfully implemented in frames of Technical Assistance for the Commonwealth of Independent States (TACIS) Program, Project financed by European Bank for Reconstruction and Development (EBRD), as well as in frames of Agreements on Cooperation between Leningrad NPP and Radiation and Nuclear safety Authority of Finland (STUK) and Swedish Nuclear Power Inspectorate, International Co-operation Program SKI-ICP(SIP). All these projects were directed to the safety increasing of the Leningrad NPP reactor, type RBMK-1000. Implementation of the technical aid projects has been performed by different foreign companies such as Aarsleff Oy, (Finland), SGN (France), Nukem (Germany), Jergo AB (Sweden), SABAROS (Switzerland), Westinghouse (USA), Nordion (Canada), Bruel and Kjer (Denmark), Data System and Solutions (UK), SVT Braundshuz (Germany) WICOTEC (Sweden), Studsvik (Sweden) and etc. which has enough technical and organizational experience in implementation of such projects, as well as all necessary certificates and licenses for works performance. Selection of a Contractor/Supplier for a joined work performance has been carried out in accordance with the tender procedure, technical specification and a planned budget. Project financing was covered by foreign Consolidated Funds and Authorities interested in increasing of Leningrad NPP safety, which have valid intergovernmental agreements with Russian Federation on the technical assistance to be provided to the NPPs. At present time all joined international projects implemented at Leningrad NPP are financed jointly with LNPP. All projects can be divided into technical aid projects connected with development and turnkey implementation of systems and complexes and projects for supply of equipment which has no analogues in Russia but successfully used all over the world. Positive experience of the joined projects

  1. Vocationalization of Secondary Schools: Implementation Reality or Fallacy?

    Directory of Open Access Journals (Sweden)

    Leona Mandiudza

    2013-02-01

    Full Text Available The study attempted to evaluate one of the recommendations of the Nziramasanga Commission of Inquiry into Education and Training viz the vocationalisation of the Secondary Schools curriculum. The study has established that vocationalisation in most Secondary Schools is mere window dressing, as evidenced by poor to non implementation of the policy directives in most schools due to lack of infrastructure, human resources and equipment. The interviews and observations check list done showed that the implementation of vocational subjects in secondary schools is an uphill struggle. The study also revealed that the negative perception of technical subjects perpetuated from the colonial era still prevails and affects negatively the implementation of these subjects. To make matters worse on the implementation, teachers, pupils and parents still hold the idea that pupils who do technical subjects are not academically talented. Even teachers themselves have prestige in teaching academic subjects. Teachers who teach technical subjects are looked down upon just as the subjects they teach. In the end these subjects lose popularity since teachers who are able to teach them develop an inferiority complex. The study recommends a re-education of the whole nation on the value of vocational and technical subjects. Although there are policies guiding the implementation of technical and vocational subjects there is need of strict stringent policy adherence by all stakeholders.

  2. El Salvador - Formal Technical Education

    Data.gov (United States)

    Millenium Challenge Corporation — With a budget of nearly $20 million, the Formal Technical Education Sub-Activity was designed to strengthen technical and vocational educational institutions in the...

  3. Dairy consumption and ovarian cancer risk in the Netherlands Cohort Study on diet and cancer

    OpenAIRE

    Mommers, M.; Schouten, L J; Goldbohm, R. A.; Brandt, P.A. van den

    2006-01-01

    Ovary cancer risk in relation to consumption of dairy products was investigated using a self-administered questionnaire on dietary habits and other risk factors for cancer, which was completed in 1986 by 62 573 postmenopausal women participating in the Netherlands Cohort Study. Follow-up for cancer was implemented by annual record linkage with the Netherlands Cancer Registry and a nationwide pathology registry. After 11.3 years of follow-up, data of 252 incident epithelial ovarian cancer case...

  4. Efficacy of a touchscreen computer based family cancer history questionnaire and subsequent cancer risk assessment

    OpenAIRE

    Westman, J; Hampel, H.; Bradley, T.

    2000-01-01

    OBJECTIVE—A computer based touchscreen family cancer history questionnaire was developed and implemented to facilitate the provision of cancer risk assessments for the ambulatory and outpatient populations of a free standing cancer hospital.
METHODS—A questionnaire consisting of a series of branched point decision making screens was developed which enables the participant to enter demographic data, personal cancer history, and cancer histories for first and second degree relatives. A freestan...

  5. Implementing Time Travel for the Web

    Directory of Open Access Journals (Sweden)

    Robert Sanderson

    2011-04-01

    Full Text Available This article discusses the challenges and solutions discovered for implementing the Memento protocol in a variety of browser environments. It describes the design and deployment of the client technologies which have been developed: a web application that functioned as a browser, an add-on for FireFox called MementoFox, a plugin for Internet Explorer and an Android-based client application. The design and technical solutions identified during the development will be of interest to those considering implementation of a Memento based platform, especially on the client side, however the interactions are also important for building conformant server-side systems.

  6. Implementation of short-term prediction

    Energy Technology Data Exchange (ETDEWEB)

    Landberg, L.; Joensen, A.; Giebel, G. [and others

    1999-03-01

    This paper will giver a general overview of the results from a EU JOULE funded project (`Implementing short-term prediction at utilities`, JOR3-CT95-0008). Reference will be given to specialised papers where applicable. The goal of the project was to implement wind farm power output prediction systems in operational environments at a number of utilities in Europe. Two models were developed, one by Risoe and one by the Technical University of Denmark (DTU). Both prediction models used HIRLAM predictions from the Danish Meteorological Institute (DMI). (au) EFP-94; EU-JOULE. 11 refs.

  7. Implementing Time Travel for the Web

    OpenAIRE

    Robert Sanderson; Harihar Shankar; Scott Ainsworth; Frank McCown; Sam Adams

    2011-01-01

    This article discusses the challenges and solutions discovered for implementing the Memento protocol in a variety of browser environments. It describes the design and deployment of the client technologies which have been developed: a web application that functioned as a browser, an add-on for FireFox called MementoFox, a plugin for Internet Explorer and an Android-based client application. The design and technical solutions identified during the development will be of interest to those consid...

  8. NJOY implementation on IBM/AMDAHL

    International Nuclear Information System (INIS)

    In early 1988 the Institute of Spaceflight and Reactor Technology at the Technical University of Braunschweig started with the implementation of NJOY 6/83 and a few months later with version 87.0 on IBM/AMDAHL. The use of short word computers beared several machine-dependent problems, which have been solved and which are depicted. Some other errors were found, too and are also listed. Two suggestions concerning COMMON blocks and CHARACTER items conclude the article

  9. Implementation of Digital Watermarking Using MATLAB Software

    OpenAIRE

    Karnpriya Vyas; Kirti Sethiya; Sonu Jain

    2012-01-01

    Digital watermarking holds significant promise as one of the keys to protecting proprietary digital content in the coming years. It focuses on embedding information inside a digital object such that the embedded information is in separable bound to the object. The proposed scheme has been implemented on MATLAB, as it is a high level technical computing language and interactive environment for algorithm development, data visualization, data analysis, and numerical computation. We wanted to ...

  10. Bioethics for Technical Experts

    Science.gov (United States)

    Asano, Shigetaka

    Along with rapidly expanding applications of life science and technology, technical experts have been implicated more and more often with ethical, social, and legal problems than before. It should be noted that in this background there are scientific and social uncertainty elements which are inevitable during the progress of life science in addition to the historically-established social unreliability to scientists and engineers. In order to solve these problems, therefore, we should establish the social governance with ‘relief’ and ‘reliance’ which enables for both citizens and engineers to share the awareness of the issues, to design social orders and criterions based on hypothetical sense of values for bioethics, to carry out practical use management of each subject carefully, and to improve the sense of values from hypothetical to universal. Concerning these measures, the technical experts can learn many things from the present performance in the medical field.

  11. Technical Training: Places available

    CERN Multimedia

    Monique Duval

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. The number of places available may vary. Please check our Web site to find out the current availability. Places are available in the following courses: The Joint PVSS JCOP Framework: 14 - 18.6.2004 (5 days) EXCEL 2003 - niveau 2 : 17 & 18.6.2004 (2 jours) MAGNE-04 : Magnétisme pour l'électrotechnique : 6 au 8.7.2004 (3 jours) Technical Training Monique Duval - Tel.74924 technical.training@cern.ch

  12. Independent technical review, handbook

    International Nuclear Information System (INIS)

    Purpose Provide an independent engineering review of the major projects being funded by the Department of Energy, Office of Environmental Restoration and Waste Management. The independent engineering review will address questions of whether the engineering practice is sufficiently developed to a point where a major project can be executed without significant technical problems. The independent review will focus on questions related to: (1) Adequacy of development of the technical base of understanding; (2) Status of development and availability of technology among the various alternatives; (3) Status and availability of the industrial infrastructure to support project design, equipment fabrication, facility construction, and process and program/project operation; (4) Adequacy of the design effort to provide a sound foundation to support execution of project; (5) Ability of the organization to fully integrate the system, and direct, manage, and control the execution of a complex major project

  13. Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Maxwell, Mike, J., P.E.

    2012-08-30

    The STI product is the Final Technical Report from ReliOn, Inc. for contract award DE-EE0000487: Recovery Act PEM Fuel Cell Systems Providing Emergency Reserve and Backup Power. The program covered the turnkey deployment of 431 ReliOn fuel cell systems at 189 individual sites for AT&T and PG&E with ReliOn functioning as the primary equipment supplier and the project manager. The Final Technical Report provides an executive level summary, a comparison of the actual accomplishments vs. the goals and objectives of the project, as well as a summary of the project activity from the contract award date of August 1, 2009 through the contract expiration date of December 31, 2011. Two photos are included in the body of the report which show hydrogen storage and bulk hydrogen refueling technologies developed as a result of this program.

  14. Independent technical review, handbook

    Energy Technology Data Exchange (ETDEWEB)

    1994-02-01

    Purpose Provide an independent engineering review of the major projects being funded by the Department of Energy, Office of Environmental Restoration and Waste Management. The independent engineering review will address questions of whether the engineering practice is sufficiently developed to a point where a major project can be executed without significant technical problems. The independent review will focus on questions related to: (1) Adequacy of development of the technical base of understanding; (2) Status of development and availability of technology among the various alternatives; (3) Status and availability of the industrial infrastructure to support project design, equipment fabrication, facility construction, and process and program/project operation; (4) Adequacy of the design effort to provide a sound foundation to support execution of project; (5) Ability of the organization to fully integrate the system, and direct, manage, and control the execution of a complex major project.

  15. Understanding Socio Technical Modularity

    DEFF Research Database (Denmark)

    Thuesen, Christian Langhoff; Kudsk, Anders; Hvam, Lars

    2011-01-01

    Theory in particular. By formulating modularity from an ANT perspective covering social, material and process aspects, the modularity of a socio-technical system can be understood as an entanglement of product, process, organizational and institutional modularity. The theoretical framework is illustrated......Modularity has gained an increasing popularity as a central concept for exploring product structure, process structure, organization structure and supply chain structure. With the offset in system theory the predominant understanding of modularity however faces difficulties in explaining the social...... dimension of modularity like irrational behaviors, cultural differences, learning processes, social organization and institutional influences on modularity. The paper addresses this gab offering a reinterpretation of the modularity concept from a socio-technical perspective in general and Actor Network...

  16. KAPTUR: technical analysis report

    OpenAIRE

    Garrett, Leigh; Silva, Carlos; Gramstadt, Marie-Therese

    2012-01-01

    Led by the Visual Arts Data Service (VADS) and funded by the JISC Managing Research Data programme (2011-13) KAPTUR will discover, create and pilot a sectoral model of best practice in the management of research data in the visual arts in collaboration with four institutional partners: Glasgow School of Art; Goldsmiths, University of London; University for the Creative Arts; and University of the Arts London. This report is framed around the research question: which technical system is mo...

  17. Percutaneous vertebroplasty: technical considerations

    Institute of Scientific and Technical Information of China (English)

    Gao-jun TENG; Shi-cheng HE

    2005-01-01

    Percutaneous vertebroplasty (PVP) is a relative new interventional technique, which is widely used in treatment of vertebral collapse caused by vertebral neoplasms and osteoporotic compression fractures. The general technical considerations of PVP techniques are discussed based on authors' experience obtained over 400 patients in the past years in this article, including preparation of PMMA, instrument of PVP, guidance and puncture approaches, and technique of the procedure, etc. The conclusion is that PVP is a safe procedure if the physicians handle it properly.

  18. Stroke Briefing: Technical Documentation

    OpenAIRE

    Institute of Public Health in Ireland

    2012-01-01

    A stroke happens when blood flow to a part of the brain is interrupted by a blocked or burst blood vessel. A lack of blood supply can damage brain cells and affect body functions. IPH has systematically estimated and forecast the prevalence of stroke on the island of Ireland. This document details the methods used to calculate these estimates and forecasts. Technical documentation      

  19. Technical training - Places available

    CERN Multimedia

    2012-01-01

    If you would like more information on a course, or for any other inquiry/suggestions, please contact Technical.Training@cern.ch Valeria Perez Reale, Learning Specialist, Technical Programme Coordinator (Tel.: 62424) Eva Stern and Elise Romero, Technical Training Administration (Tel.: 74924) HR Department Electronic Design Next Session Duration Language Availability Comprehensive VHDL for FPGA Design 08-Oct-12 to 12-Oct-12 5 days English 4 places Electrostatique / Protection ESD 28-Sep-12 to 28-Sep-12 3 hours French 25 places Impacts de la suppression du plomb (RoHS) en électronique 26-Oct-12 to 26-Oct-12 8 hours French 14 places Introduction to VHDL 10-Oct-12 to 11-Oct-12 2 days English 9 places LabVIEW Real Time and FPGA 13-Nov-12 to 16-Nov-12 5 days French 5 places LabVIEW for Experts 24-Sep-12 to 28-Sep-12 5 days English 6 places LabVIEW for beginners 15-Oct-12 to 17-...

  20. 6 Common Cancers - Lung Cancer

    Science.gov (United States)

    ... Home Current Issue Past Issues 6 Common Cancers - Lung Cancer Past Issues / Spring 2007 Table of Contents For ... for Desperate Housewives. (Photo ©2005 Kathy Hutchins / Hutchins) Lung Cancer Lung cancer causes more deaths than the next ...