WorldWideScience

Sample records for cancer panel statement

  1. Early detection of lung cancer: A statement from an expert panel of the Swiss university hospitals on lung cancer screening

    OpenAIRE

    Frauenfelder, T.; Puhan, Milo A.; Lazor, R; von Garnier, C; Bremerich, J; Niemann, T.; Christe, A; Montet, X; Gautschi, O.; Weder, W; Kohler, M.

    2014-01-01

    The discussion about setting up a program for lung cancer screening was launched with the publication of the results of the National Lung Screening Trial, which suggested reduced mortality in high-risk subjects undergoing CT screening. However, important questions about the benefit-harm balance and the details of a screening program and its cost-effectiveness remain unanswered. A panel of specialists in chest radiology, respiratory medicine, epidemiology, and thoracic surgery representing all...

  2. International expert panel on inflammatory breast cancer: consensus statement for standardized diagnosis and treatment

    OpenAIRE

    S Dawood; Merajver, S. D.; Viens, P.; Vermeulen, P B; Swain, S. M.; Buchholz, T. A.; Dirix, L Y; Levine, P. H.; Lucci, A.; Krishnamurthy, S.; Robertson, F. M.; Woodward, W. A.; W. T. Yang; Ueno, N T; Cristofanilli, M

    2010-01-01

    Background: Inflammatory breast cancer (IBC) represents the most aggressive presentation of breast cancer. Women diagnosed with IBC typically have a poorer prognosis compared with those diagnosed with non-IBC tumors. Recommendations and guidelines published to date on the diagnosis, management, and follow-up of women with breast cancer have focused primarily on non-IBC tumors. Establishing a minimum standard for clinical diagnosis and treatment of IBC is needed.

  3. Developing cancer warning statements for alcoholic beverages

    OpenAIRE

    Pettigrew, Simone; Jongenelis, Michelle; Chikritzhs, Tanya; Slevin, Terry; Pratt, Iain S; Glance, David; Liang, Wenbin

    2014-01-01

    Background There is growing evidence of the increased cancer risk associated with alcohol consumption, but this is not well understood by the general public. This study investigated the acceptability among drinkers of cancer warning statements for alcoholic beverages. Methods Six focus groups were conducted with Australian drinkers to develop a series of cancer-related warning statements for alcohol products. Eleven cancer warning statements and one general health warning statement were subse...

  4. Current practice with endoscopic submucosal dissection in Europe: position statement from a panel of experts

    DEFF Research Database (Denmark)

    Deprez, P H; Bergman, J J; Meisner, S;

    2010-01-01

    cases, no description of training programs, and few published reports. In 2008, a panel of experts gathered in Rotterdam to discuss indications, training, and the wider use of ESD. The panel of experts and participants reached a consensus on five general statements: 1) ESD aims at treating mucosal...... cancer; 2) treatment aims for R0 resection; 3) ESD should meet quality standards; 4) ESD should be performed following national or European Society of Gastrointestinal Endoscopy (ESGE) guidelines or under institutional review board approval; and 5) ESD cases should be registered. Due to the high level of......: good quality imaging, experienced histopathologist following the Japanese criteria (2-mm sections, micrometric invasion, vessel and lymphatic infiltration, etc), and dedicated endoscopic follow-up. Moreover, minimum training requirements were also defined: knowledge in indications and instruments...

  5. American Society of Clinical Oncology Policy Statement Update: Genetic and Genomic Testing for Cancer Susceptibility.

    Science.gov (United States)

    Robson, Mark E; Bradbury, Angela R; Arun, Banu; Domchek, Susan M; Ford, James M; Hampel, Heather L; Lipkin, Stephen M; Syngal, Sapna; Wollins, Dana S; Lindor, Noralane M

    2015-11-01

    The American Society of Clinical Oncology (ASCO) has long affirmed that the recognition and management of individuals with an inherited susceptibility to cancer are core elements of oncology care. ASCO released its first statement on genetic testing in 1996 and updated that statement in 2003 and 2010 in response to developments in the field. In 2014, the Cancer Prevention and Ethics Committees of ASCO commissioned another update to reflect the impact of advances in this area on oncology practice. In particular, there was an interest in addressing the opportunities and challenges arising from the application of massively parallel sequencing-also known as next-generation sequencing-to cancer susceptibility testing. This technology introduces a new level of complexity into the practice of cancer risk assessment and management, requiring renewed effort on the part of ASCO to ensure that those providing care to patients with cancer receive the necessary education to use this new technology in the most effective, beneficial manner. The purpose of this statement is to explore the challenges of new and emerging technologies in cancer genetics and provide recommendations to ensure their optimal deployment in oncology practice. Specifically, the statement makes recommendations in the following areas: germline implications of somatic mutation profiling, multigene panel testing for cancer susceptibility, quality assurance in genetic testing, education of oncology professionals, and access to cancer genetic services. PMID:26324357

  6. Panel to consider a position statement on the importance of teaching evolution

    Science.gov (United States)

    Folger, Peter

    AGU President John Knauss has authorized a panel to revise the existing AGU position statement, which opposes the teaching of creationism or any other religious tenet as science. The current statement, first adopted in December 1981, and most recently reaffirmed in May 1998, is as follows:“The Council of the American Geophysical Union notes with concern the continuing efforts by creationists for administrative, legislative, and juridical actions designed to require or promote the teaching of creationism as a scientific theory. The American Geophysical Union is opposed to all efforts to require or promote the teaching of creationism or any other religious tenet as science.”

  7. Proteomic Approaches for Biomarker Panels in Cancer.

    Science.gov (United States)

    Tanase, Cristiana; Albulescu, Radu; Neagu, Monica

    2016-01-01

    Proteomic technologies remain the main backbone of biomarkers discovery in cancer. The continuous development of proteomic technologies also enlarges the bioinformatics domain, thus founding the main pillars of cancer therapy. The main source for diagnostic/prognostic/therapy monitoring biomarker panels are molecules that have a dual role, being both indicators of disease development and therapy targets. Proteomic technologies, such as mass-spectrometry approaches and protein array technologies, represent the main technologies that can depict these biomarkers. Herein, we will illustrate some of the most recent strategies for biomarker discovery in cancer, including the development of immune-markers and the use of cancer stem cells as target therapy. The challenges of proteomic biomarker discovery need new forms of cross-disciplinary conglomerates that will result in increased and tailored access to treatments for patients; diagnostic companies would benefit from the enhanced co-development of companion diagnostics and pharmaceutical companies. In the technology optimization in biomarkers, immune assays are the leaders of discovery machinery. PMID:26565430

  8. A Methylation Panel for Bladder Cancer — EDRN Public Portal

    Science.gov (United States)

    Participate in a prevalidation study for methylation based detection of bladder cancer. In addition, a panel of three markers identified will be evaluated for their ability to a) identify bladder cancer patients from those with benign urologic disease; b) identify patients with superficial (papillary) cancers from those with high grade invasive cancers

  9. The Effect of Cancer Warning Statements on Alcohol Consumption Intentions

    Science.gov (United States)

    Pettigrew, Simone; Jongenelis, Michelle I.; Glance, David; Chikritzhs, Tanya; Pratt, Iain S.; Slevin, Terry; Liang, Wenbin; Wakefield, Melanie

    2016-01-01

    In response to increasing calls to introduce warning labels on alcoholic beverages, this study investigated the potential effectiveness of alcohol warning statements designed to increase awareness of the alcohol-cancer link. A national online survey was administered to a diverse sample of Australian adult drinkers (n = 1,680). Along with…

  10. Robust multi-tissue gene panel for cancer detection

    Directory of Open Access Journals (Sweden)

    Talantov Dmitri

    2010-06-01

    Full Text Available Abstract Background We have identified a set of genes whose relative mRNA expression levels in various solid tumors can be used to robustly distinguish cancer from matching normal tissue. Our current feature set consists of 113 gene probes for 104 unique genes, originally identified as differentially expressed in solid primary tumors in microarray data on Affymetrix HG-U133A platform in five tissue types: breast, colon, lung, prostate and ovary. For each dataset, we first identified a set of genes significantly differentially expressed in tumor vs. normal tissue at p-value = 0.05 using an experimentally derived error model. Our common cancer gene panel is the intersection of these sets of significantly dysregulated genes and can distinguish tumors from normal tissue on all these five tissue types. Methods Frozen tumor specimens were obtained from two commercial vendors Clinomics (Pittsfield, MA and Asterand (Detroit, MI. Biotinylated targets were prepared using published methods (Affymetrix, CA and hybridized to Affymetrix U133A GeneChips (Affymetrix, CA. Expression values for each gene were calculated using Affymetrix GeneChip analysis software MAS 5.0. We then used a software package called Genes@Work for differential expression discovery, and SVM light linear kernel for building classification models. Results We validate the predictability of this gene list on several publicly available data sets generated on the same platform. Of note, when analysing the lung cancer data set of Spira et al, using an SVM linear kernel classifier, our gene panel had 94.7% leave-one-out accuracy compared to 87.8% using the gene panel in the original paper. In addition, we performed high-throughput validation on the Dana Farber Cancer Institute GCOD database and several GEO datasets. Conclusions Our result showed the potential for this panel as a robust classification tool for multiple tumor types on the Affymetrix platform, as well as other whole genome arrays

  11. Panel Reviews Benefits and Harms of CT Scans for Lung Cancer Screening | Division of Cancer Prevention

    Science.gov (United States)

    A panel of experts has reviewed the evidence regarding the benefits and harms of screening for lung cancer with low-dose computed tomography (CT) and concluded that the technology may benefit some individuals at high risk for lung cancer. But the panel cautioned that many questions remain about the potential harms of screening and how to translate screening into clinical practice. |

  12. MORPHOMETRIC SUBTYPING FOR A PANEL OF BREAST CANCER CELL LINES

    Energy Technology Data Exchange (ETDEWEB)

    Han, Ju; Chang, Hang; Fontenay, Gerald; Wang, Nicholas J.; Gray, Joe W.; Parvin, Bahram

    2009-05-08

    A panel of cell lines of diverse molecular background offers an improved model system for high-content screening, comparative analysis, and cell systems biology. A computational pipeline has been developed to collect images from cell-based assays, segment individual cells and colonies, represent segmented objects in a multidimensional space, and cluster them for identifying distinct subpopulations. While each segmentation strategy can vary for different imaging assays, representation and subpopulation analysis share a common thread. Application of this pipeline to a library of 41 breast cancer cell lines is demonstrated. These cell lines are grown in 2D and imaged through immunofluorescence microscopy. Subpopulations in this panel are identified and shown to correlate with previous subtyping literature that was derived from transcript data.

  13. Genotyping panel for assessing response to cancer chemotherapy

    Directory of Open Access Journals (Sweden)

    Hampel Heather

    2008-06-01

    Full Text Available Abstract Background Variants in numerous genes are thought to affect the success or failure of cancer chemotherapy. Interindividual variability can result from genes involved in drug metabolism and transport, drug targets (receptors, enzymes, etc, and proteins relevant to cell survival (e.g., cell cycle, DNA repair, and apoptosis. The purpose of the current study is to establish a flexible, cost-effective, high-throughput genotyping platform for candidate genes involved in chemoresistance and -sensitivity, and treatment outcomes. Methods We have adopted SNPlex for genotyping 432 single nucleotide polymorphisms (SNPs in 160 candidate genes implicated in response to anticancer chemotherapy. Results The genotyping panels were applied to 39 patients with chronic lymphocytic leukemia undergoing flavopiridol chemotherapy, and 90 patients with colorectal cancer. 408 SNPs (94% produced successful genotyping results. Additional genotyping methods were established for polymorphisms undetectable by SNPlex, including multiplexed SNaPshot for CYP2D6 SNPs, and PCR amplification with fluorescently labeled primers for the UGT1A1 promoter (TAnTAA repeat polymorphism. Conclusion This genotyping panel is useful for supporting clinical anticancer drug trials to identify polymorphisms that contribute to interindividual variability in drug response. Availability of population genetic data across multiple studies has the potential to yield genetic biomarkers for optimizing anticancer therapy.

  14. Further statement on the incidence of childhood cancer in Wales

    International Nuclear Information System (INIS)

    In March 1999 the Welsh Office asked COMARE to examine two unpublished studies. The first by Busby et al of ''Green Audit'' concluded that there was a significant excess of childhood leukaemia in North Wales associated with residential proximity to the coast. The second study, carried out by Steward et al of the Welsh Cancer Intelligence and Surveillance Unit (WCISU), did not support this conclusion. We were asked to advise as to whether we considered that there was a real raised incidence of childhood leukaemia near the coast of North Wales and whether further study was required. To do this we initially organised a comparison of the figures quoted by both the Green Audit and WCISU with the database held by the Childhood Cancer Research Group (CCRG) in Oxford. This group maintains the National Registry of Childhood Tumours (NRCT), data for which are supplied from a variety of sources including cancer registries but also directly from medical cancer specialists as well as from death certificates. As a consequence this provides an independent check on much of the data on childhood cancer held by cancer registries in Great Britain and is clinically validated. After carrying out the independent check on the number of cases of childhood leukaemia in these Welsh counties it was immediately apparent that the data held by Green Audit, on which the analysis by Busby et al was based, were incorrect. These data were received from the Welsh Cancer Registry (WCR) in 1995. A further data set was received from WCR in 1996 but was not used in the analysis by Busby et al. In June 1999 we issued a statement to the Welsh Office. In that statement we noted that Dr Busby and his colleagues appeared to have used erroneous data in their study. On the basis of the Steward et al data, COMARE also stated that we found no evidence to support the contention that there is an increased incidence of childhood leukaemia or other childhood cancers amongst the Welsh population living close to the

  15. Introduction statement at the panel discussion [contributed by H. Reijonen, IAEA

    International Nuclear Information System (INIS)

    Full text: Introduction at the Panel discussion: I'm really not prepared to make any policy statements at this stage because the multi-lateral-informational exercises on this topic are still taking their form. I may just briefly mention what the Agency has been doing on this topic during the last six months or so. Last May we had an advisory group meeting in Vienna with a topic 'Research Reactor Renewal and Upgrading Program', but did not consider only fuel cycle questions but also other matters of interest. The outcome of this meeting will be submitted to the International Nuclear Fuel Cycle Evaluation Working Group. We have just published the proceedings of this meeting which is the 'Agency Technical Document, No. 214'. This is a cost-free publication that we can send to any one of you who wishes to have it and the secretaries at the Information Desk have an order list so during the break if you just please write down your name and address we shall then send the document to you. Some sort of continuation to that meeting and also a continuation to the discussion that we have had here yesterday and today, we are planning to have a consultant's meeting in preparation of the program on research reactor core conversions to use low enriched uranium instead of highly enriched uranium. This exercise has been coordinated with INFCE and it is not the intention that work would be duplicating each other but rather all meeting at the end of November, early December, is something that we would like to look at concrete cases i mainly developing countries that are currently utilizing highly enriched uranium so that we would like to make some sort of a check list or technical evaluation of what must be done in certain country cases to prepare core conversions that would utilize the new fuel designs that have been discussed here yesterday and today. We also hope that during the meeting in about three weeks, we could discuss some demonstration projects or programs that could take

  16. U.S. Panel Says Evidence 'Insufficient' to Recommend Skin Cancer Screenings

    Science.gov (United States)

    ... html U.S. Panel Says Evidence 'Insufficient' to Recommend Skin Cancer Screenings But dermatology experts disagree and worry opportunities ... proof to recommend regular full-body exams for skin cancer as a means of preventing deaths from these ...

  17. Expert Panel Reaffirms Daily Aspirin's Use Against Heart Disease, Colon Cancer

    Science.gov (United States)

    ... Panel Reaffirms Daily Aspirin's Use Against Heart Disease, Colon Cancer Guideline applies to people in their 50s, many ... reduce their risk of both heart disease and colon cancer, the U.S. Preventive Services Task Force (USPSTF) recommends. ...

  18. Cell Line Modeling to Study Biomarker Panel in Prostate Cancer

    Science.gov (United States)

    NickKholgh, Bita; Fang, Xiaolan; Winters, Shira M.; Raina, Anvi; Pandya, Komal S.; Gyabaah, Kenneth; Fino, Nora; Balaji, K.C.

    2016-01-01

    BACKGROUND African–American men with prostate cancer (PCa) present with higher-grade and -stage tumors compared to Caucasians. While the disparity may result from multiple factors, a biological basis is often strongly suspected. Currently, few well-characterized experimental model systems are available to study the biological basis of racial disparity in PCa. We report a validated in vitro cell line model system that could be used for the purpose. METHODS We assembled a PCa cell line model that included currently available African–American PCa cell lines and LNCaP (androgen-dependent) and C4-2 (castration-resistant) Caucasian PCa cells. The utility of the cell lines in studying the biological basis of variance in a malignant phenotype was explored using a multiplex biomarker panel consisting of proteins that have been proven to play a role in the progression of PCa. The panel expression was evaluated by Western blot and RT-PCR in cell lines and validated in human PCa tissues by RT-PCR. As proof-of-principle to demonstrate the utility of our model in functional studies, we performed MTS viability assays and molecular studies. RESULTS The dysregulation of the multiplex biomarker panel in primary African–American cell line (E006AA) was similar to metastatic Caucasian cell lines, which would suggest that the cell line model could be used to study an inherent aggressive phenotype in African–American men with PCa. We had previously demonstrated that Protein kinase D1 (PKD1) is a novel kinase that is down regulated in advanced prostate cancer. We established the functional relevance by over expressing PKD1, which resulted in decreased proliferation and epithelial mesenchymal transition (EMT) in PCa cells. Moreover, we established the feasibility of studying the expression of the multiplex biomarker panel in archived human PCa tissue from African–Americans and Caucasians as a prelude to future translational studies. CONCLUSION We have characterized a novel in

  19. Statement

    International Nuclear Information System (INIS)

    Full text: I want to focus on the two questions related to decommissioning and waste management posed to the panel, that I would like to restate as a question: Is it possible to decommission a nuclear facility and deal with the related wastes in case of absence of a final waste repository? My answer to this question is: the decommissioning of a nuclear facility is possible and should be pursued as far ahead of time as possible. The reasons for this statement are many. The most important ones are safety and costs. A nuclear power plant, at the moment of final shutdown, has thousands of square metres of contaminated surfaces, thousands of tonnes of activated materials and normally also many cubic metres of radioactive liquids that must continue to be kept isolated from the environment. This means continued and extensive maintenance and surveillance. First, decommissioning actions, that is decontamination and liquid waste solidification, should be carried out to reduce risk, maintenance and surveillance, and to minimize the production of additional operational wastes. Other decommissioning actions can minimize the volume and surface of wastes. The best, of course, would be to proceed also with waste conditioning. Is this possible without the availability of a repository? In my opinion - particularly if we are referring to a repository with engineered barriers - this is possible with minimum financial risk, on the basis of a clear definition of the areas of responsibility between waste producers and the body in charge of the repository. Let us analyse the problem in more detail. Today the average dimensions of a waste package and the expected radioactivity content are basically standardized. The data to be collected, in order for adequate waste package characterization, are also generally known. Even better is if the data are collected according to the guidance in certain IAEA publications, such as the one being published on record keeping and one on waste inventory

  20. Toward Earlier Inclusion of Pregnant and Postpartum Women in Tuberculosis Drug Trials: Consensus Statements From an International Expert Panel.

    Science.gov (United States)

    Gupta, Amita; Mathad, Jyoti S; Abdel-Rahman, Susan M; Albano, Jessica D; Botgros, Radu; Brown, Vikki; Browning, Renee S; Dawson, Liza; Dooley, Kelly E; Gnanashanmugam, Devasena; Grinsztejn, Beatriz; Hernandez-Diaz, Sonia; Jean-Philippe, Patrick; Kim, Peter; Lyerly, Anne D; Mirochnick, Mark; Mofenson, Lynne M; Montepiedra, Grace; Piper, Jeanna; Sahin, Leyla; Savic, Radojka; Smith, Betsy; Spiegel, Hans; Swaminathan, Soumya; Watts, D Heather; White, Amina

    2016-03-15

    Tuberculosis is a major cause of morbidity and mortality in women of childbearing age (15-44 years). Despite increased tuberculosis risk during pregnancy, optimal clinical treatment remains unclear: safety, tolerability, and pharmacokinetic data for many tuberculosis drugs are lacking, and trials of promising new tuberculosis drugs exclude pregnant women. To advance inclusion of pregnant and postpartum women in tuberculosis drug trials, the US National Institutes of Health convened an international expert panel. Discussions generated consensus statements (>75% agreement among panelists) identifying high-priority research areas during pregnancy, including: (1) preventing progression of latent tuberculosis infection, especially in women coinfected with human immunodeficiency virus; (2) evaluating new agents/regimens for treatment of multidrug-resistant tuberculosis; and (3) evaluating safety, tolerability and pharmacokinetics of tuberculosis drugs already in use during pregnancy and postpartum. Incorporating pregnant women into clinical trials would extend evidence-based tuberculosis prevention and treatment standards to this special population. PMID:26658057

  1. Comparison of proteomic biomarker panels in urine and serum for ovarian cancer diagnosis

    DEFF Research Database (Denmark)

    Petri, Anette Lykke; Simonsen, Anja Hviid; Høgdall, Estrid; Christensen, Ib Jarle; Kjaer, Susanne Krüger; Yip, Christine; Risum, Signe Normann; Pedersen, Anette Tønnes; Hartwell, Dorte; Fung, Eric T; Høgdall, Claus

    2010-01-01

    The purposes of this study were to confirm previously found candidate epithelial ovarian cancer biomarkers in urine and to compare a paired serum biomarker panel and a urine biomarker panel from the same study cohort with regard to the receiver operating characteristic curve (ROC) area under the ...

  2. Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas

    Directory of Open Access Journals (Sweden)

    Lind Guro E

    2011-07-01

    Full Text Available Abstract Background The presence of cancer-specific DNA methylation patterns in epithelial colorectal cells in human feces provides the prospect of a simple, non-invasive screening test for colorectal cancer and its precursor, the adenoma. This study investigates a panel of epigenetic markers for the detection of colorectal cancer and adenomas. Methods Candidate biomarkers were subjected to quantitative methylation analysis in test sets of tissue samples from colorectal cancers, adenomas, and normal colonic mucosa. All findings were verified in independent clinical validation series. A total of 523 human samples were included in the study. Receiver operating characteristic (ROC curve analysis was used to evaluate the performance of the biomarker panel. Results Promoter hypermethylation of the genes CNRIP1, FBN1, INA, MAL, SNCA, and SPG20 was frequent in both colorectal cancers (65-94% and adenomas (35-91%, whereas normal mucosa samples were rarely (0-5% methylated. The combined sensitivity of at least two positives among the six markers was 94% for colorectal cancers and 93% for adenoma samples, with a specificity of 98%. The resulting areas under the ROC curve were 0.984 for cancers and 0.968 for adenomas versus normal mucosa. Conclusions The novel epigenetic marker panel shows very high sensitivity and specificity for both colorectal cancers and adenomas. Our findings suggest this biomarker panel to be highly suitable for early tumor detection.

  3. Statement on the comments by Hattingh et al. (2014 on the EFSA PLH Panel (2014 Scientific Opinion on Citrus Black Spot

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Plant Health (PLH

    2015-01-01

    Full Text Available Following a request from the European Commission, the EFSA Panel on Plant Health (EFSA PLH Panel was asked to react to a document entitled “Comments on the European Union Food Safety Authority’s Pest Risk Assessment for Phyllosticta citricarpa”, authored by Hattingh et al., which was posted online in August 2014 on the website of Citrus Research International (Pty Ltd, South Africa. Citrus black spot (CBS, caused by the fungus Phyllosticta citricarpa (McAlpine Van der Aa, is a fruit-blemishing and leaf-spotting disease affecting citrus. P. citricarpa is not known to occur in the EU territory and is regulated as a quarantine organism in citrus (Council Directive 2000/29/EC. The Panel assessed the comments by Hattingh et al. in the light of the content of the EFSA PLH Panel Scientific Opinion on CBS and the EFSA report detailing responses to comments received during the public consultation on the draft opinion. The Panel stands by the EFSA PLH Panel Scientific Opinion on CBS and considers that the comments by Hattingh et al. have been thoroughly addressed in the EFSA report on the public consultation on the EFSA PLH Panel Scientific Opinion on CBS. A detailed point by point reply to the comments by Hattingh et al. is provided in an Appendix of this Panel statement. Since September 2014, EFSA has written to the lead author of the comments trying to engage in a scientific dialogue concerning the sources of uncertainty related to the risks posed by P. citricarpa to plant health in the EU, so as to identify ways to reduce such uncertainties (e.g. with further research and/or data exchange. The EFSA PLH Panel also remains open to such constructive dialogue in the future.

  4. Bisphosphonate use in patients with lung cancer and bone metastases: recommendations of a European expert panel

    DEFF Research Database (Denmark)

    De Marinis, Filippo; Eberhardt, Wilfried; Harper, Peter G;

    2009-01-01

    INTRODUCTION: Bisphosphonates (BPs) are effective in preventing, reducing the incidence, and delaying the onset of skeletal-related events in patients with bone metastases in a variety of solid tumors, including lung cancer. The purpose of this article is to review the current evidence for the use...... of BPs in lung cancer and to provide specific European recommendations to support the clinical practice of using BPs to treat patients with lung cancer with bone metastases. METHODS: An expert panel of European clinical oncologists and lung cancer specialists convened for two face-to-face meetings...... designed to review available evidence on the efficacy of BPs in lung cancer and to develop recommendations based on published literature and clinical practice experiences. RESULTS: The panel recommends screening patients with lung cancer for bone metastases at the initial staging of disease to assess...

  5. [NCCN Asian consensus statement - can Asian patients with cancer accept treatment modalities from NCCN guidelines ?].

    Science.gov (United States)

    Ozono, Seiichiro; Hinotsu, Shiro; Namiki, Mikio; Akaza, Hideyuki

    2014-06-01

    To spread the National Comprehensive Cancer Network(NCCN)guidelines widely in Asia, committee members from Asian countries have been preparing an Asia Consensus Statement(ACS)along the NCCN guidelines. The ACS for Kidney Cancer guidelines and Prostate Cancer guidelines were issued in 2009 and in 2011, respectively. In addition, second versions of both these guidelines were issued in 2011 and 2013, respectively. In this review, the process and contents of NCCN ACS have been described. PMID:25129079

  6. Multiple Biomarker Panels for Early Detection of Breast Cancer in Peripheral Blood

    Directory of Open Access Journals (Sweden)

    Fan Zhang

    2013-01-01

    Full Text Available Detecting breast cancer at early stages can be challenging. Traditional mammography and tissue microarray that have been studied for early breast cancer detection and prediction have many drawbacks. Therefore, there is a need for more reliable diagnostic tools for early detection of breast cancer due to a number of factors and challenges. In the paper, we presented a five-marker panel approach based on SVM for early detection of breast cancer in peripheral blood and show how to use SVM to model the classification and prediction problem of early detection of breast cancer in peripheral blood. We found that the five-marker panel can improve the prediction performance (area under curve in the testing data set from 0.5826 to 0.7879. Further pathway analysis showed that the top four five-marker panels are associated with signaling, steroid hormones, metabolism, immune system, and hemostasis, which are consistent with previous findings. Our prediction model can serve as a general model for multibiomarker panel discovery in early detection of other cancers.

  7. The Detection of Ionizing Radiation by Plasma Panel Sensors: Cosmic Muons, Ion Beams and Cancer Therapy

    CERN Document Server

    Friedman, Peter S; Chapman, J W; Ferretti, Claudio; Levin, Daniel S; Weaverdyck, Curtis; Zhou, Bing; Benhammou, Yan; Etzion, Erez; Guttman, Nir; Moshe, M Ben; Silver, Yiftah; Beene, James R; Varner, Robert L

    2012-01-01

    The plasma panel sensor is an ionizing photon and particle radiation detector derived from PDP technology with high gain and nanosecond response. Experimental results in detecting cosmic ray muons and beta particles from radioactive sources are described along with applications including high energy and nuclear physics, homeland security and cancer therapeutics

  8. American Society of Clinical Oncology Statement: Human Papillomavirus Vaccination for Cancer Prevention.

    Science.gov (United States)

    Bailey, Howard H; Chuang, Linus T; duPont, Nefertiti C; Eng, Cathy; Foxhall, Lewis E; Merrill, Janette K; Wollins, Dana S; Blanke, Charles D

    2016-05-20

    American Society of Clinical Oncology (ASCO), the leading medical professional oncology society, is committed to lessening the burden of cancer and as such will promote underused interventions that have the potential to save millions of lives through cancer prevention. As the main providers of cancer care worldwide, our patients, their families, and our communities look to us for guidance regarding all things cancer related, including cancer prevention. Through this statement and accompanying recommendations, ASCO hopes to increase awareness of the tremendous global impact of human papillomavirus (HPV) -caused cancers, refocus the discussion of HPV vaccination on its likely ability to prevent millions of cancer deaths, and increase HPV vaccination uptake via greater involvement of oncology professionals in ensuring accurate public discourse about HPV vaccination and calling for the implementation of concrete strategies to address barriers to vaccine access and acceptance. PMID:27069078

  9. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014. Statement on the safety of ‘Cetyl Myristoleate Complex’ as an ingredient in food supplements

    DEFF Research Database (Denmark)

    Tetens, Inge

    opinion of 2010, the Panel concluded that the safety of CMC as an ingredient in food supplements at an intake of 3.3 g per day has not been established. This conclusion was based on the considerations that in the absence of appropriate data on absorption, distribution, metabolism and excretion, the......Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to update its opinion on the safety of ‘Cetyl Myristoleate Complex’ (CMC) as a novel food ingredient in the light of additional information submitted by the applicant. In its previous...

  10. Statement at World Cancer Day, 4 February 2013, Vienna, Austria

    International Nuclear Information System (INIS)

    Full Text: Good afternoon, Ladies and Gentlemen, I welcome you all to this IAEA event marking World Cancer Day 2013. I am very pleased that we have with us today Professor Kutluk, President-Elect of the Union of International Cancer Control, which initiated World Cancer Day. I also welcome the distinguished Ambassador of Sudan, H.E. Mr. Mahmoud Hassan El Amin, and Dr. Munki Lee, Minister, Permanent Mission of the Republic of Korea, as well as our own Medical Director Dr. Matthias Lademann. Many events are being held around the world today to draw attention to cancer. This year, there is a special focus on dispelling common misconceptions about the disease. One of the most persistent myths about cancer is that it is mainly a disease of wealthy countries. In fact, around 70 percent of cancer deaths occur in developing countries. Another myth is that cancer is invariably a death sentence. In reality, many cancers respond well to treatment and can even be cured. Thanks to early detection and modern treatment methods, millions of men and women now live normal lives for many decades after diagnosis. Often, they die in old age of something other than cancer. Here in Austria, as in all developed countries, we take access to radiotherapy for granted. But the picture is very different in developing countries. It is estimated that there is a shortage of around 5 000 radiotherapy machines in developing countries. That means that millions of people, in Africa and elsewhere, have no access to diagnostic services or treatment. Too many die of conditions that are actually treatable. That is an immense human tragedy. The IAEA Programme of Action for Cancer Therapy - PACT - has been working hard to try to make radiotherapy services available in all countries. Through our Technical Cooperation programme, we are supporting over 130 projects in cancer diagnosis, management and treatment. We help countries to establish oncology and radiotherapy centres. We provide extensive training for

  11. Statement at World Cancer Day, 2 February 2012, Vienna, Austria

    International Nuclear Information System (INIS)

    Full text: Good afternoon, Ladies and Gentlemen. Welcome to this IAEA event marking World Cancer Day 2012. The Agency's work in cancer control has been a high priority for me since I became Director General just over two years go. When I travel to developing countries, I try wherever possible to see IAEA cancer control projects in action. This is always very uplifting. In June and July last year, I visited a number of Latin American countries to discuss IAEA support for their cancer control efforts. In July, I went to the Mother Teresa Hospital in Tirana, Albania, where IAEA support has helped to significantly improve radiotherapy services and provided training for 23 health professionals to launch a breast cancer screening programme. In October, I had the opportunity to celebrate the opening of a new cancer therapy facility in Indonesia. Also in October, I travelled to Vietnam. I visited the Tran Hung Dao hospital in Hanoi and saw some of the most high-tech cancer treatment equipment in use there. The IAEA had facilitated the donation of a radiotherapy unit from India to Vietnam in May 2010. It was very impressive to witness how quickly a country's cancer control capabilities can be transformed. There are many such success stories throughout the world. But, of course, the need is great and there is still much work to be done. For example, there is a shortage of around 5 000 radiotherapy machines in low and middle income countries. This means that hundreds of thousands of patients are denied diagnosis and treatment that could save their lives. The IAEA Programme of Action for Cancer Therapy - PACT - has been working hard to try to make radiotherapy services available in all countries. The IAEA technical cooperation programme remains a major mechanism for providing assistance to Member States. The Agency is supporting over 130 projects in cancer diagnosis, management and treatment. Oncology and radiotherapy centres are being established in countries such as

  12. Novel serum protein biomarker panel revealed by mass spectrometry and its prognostic value in breast cancer

    OpenAIRE

    Chung, Liping; Moore, Katrina; Phillips, Leo; Boyle, Frances M.; Marsh, Deborah J.; Baxter, Robert C.

    2014-01-01

    Introduction Serum profiling using proteomic techniques has great potential to detect biomarkers that might improve diagnosis and predict outcome for breast cancer patients (BC). This study used surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry (MS) to identify differentially expressed proteins in sera from BC and healthy volunteers (HV), with the goal of developing a new prognostic biomarker panel. Methods Training set serum samples from 99 BC and 51 H...

  13. 78 FR 37843 - Notice of Intent To Prepare an Environmental Impact Statement for the Proposed Panels F and G...

    Science.gov (United States)

    2013-06-24

    ... haul road would remain open so that equipment can be transported to the shop for maintenance. The proposed 4.5-mile conveyor system would include a crusher and stockpile location on lease in Panel F. There... available at any time. While you can ask us in your comment to withhold your personal...

  14. Expert consensus statement on diagnosis and treatment of cancer-related depressed mood state based on Chinese medicine

    OpenAIRE

    Shaodan Tian; Mei Jia; Li Hou; Xinyi Chen; Dongyun Li; Tianwei Guo

    2015-01-01

    This consensus statement is organized into six parts: 1) Definitions: cancer-related depressed mood state is defined as a group of depressive symptoms, rather than major depressive disorder. Thus, “cancer-related depression” or “depressed mood state” is introduced as standard terminology and associated with the Chinese medicine concept of “yu zheng” (depression syndrome). 2) Pathogenesis: factors including psychological stress, cancer pain, cancer fatigue, sleep disorders, surgery trauma, che...

  15. Evaluation of a dual-panel PET camera design to breast cancer imaging.

    Science.gov (United States)

    Zhang, Jin; Chinn, Gary; Foudray, Angela M K; Habte, Frezghi; Olcott, Peter; Levin, Craig S

    2006-01-01

    We are developing a novel, portable dual-panel positron emission tomography (PET) camera dedicated to breast cancer imaging. With a sensitive area of approximately 150 cm(2), this camera is based on arrays of lutetium oxyorthosilicate (LSO) crystals (1x1x3 mm(3)) coupled to 11x11-mm(2) position-sensitive avalanche photodiodes (PSAPD). GATE open source software was used to perform Monte Carlo simulations to optimize the parameters for the camera design. The noise equivalent counting (NEC) rate, together with the true, scatter, and random counting rates were simulated at different time and energy windows. Focal plane tomography (FPT) was used for visualizing the tumors at different depths between the two detector panels. Attenuation and uniformity corrections were applied to images. PMID:17646005

  16. Cancer frequency in the Samtgemeinde Asse. Statement by the German Commission on Radiological Protection

    International Nuclear Information System (INIS)

    41 reported diagnoses of cancer (EKN 2010b). The EKN established in (EKN 2010b) that after correction for multiple testing the results for all the municipalities of the district of Wolfenbuettel other than the Samtgemeinde Asse were not significant. The only significant findings were the results for leukaemia and thyroid cancer in the Samtgemeinde Asse. The Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU) wrote to the Commission on Radiological Protection (SSK) on 20 December 2010 requesting a statement on the results of the EKN's analysis of the incidence of cancer in the Samtgemeinde Asse. In particular, the statement needed to examine the statistical methods used and answer the following questions: Is there radiobiological information that could plausibly explain the findings? How can the findings be explained?

  17. Modeling of response to endocrine therapy in a panel of human luminal breast cancer xenografts.

    Science.gov (United States)

    Cottu, P; Marangoni, E; Assayag, F; de Cremoux, P; Vincent-Salomon, A; Guyader, Ch; de Plater, L; Elbaz, C; Karboul, N; Fontaine, J J; Chateau-Joubert, S; Boudou-Rouquette, P; Alran, S; Dangles-Marie, V; Gentien, D; Poupon, M-F; Decaudin, D

    2012-06-01

    Resistance to endocrine therapy is a major complication of luminal breast cancer and studies of the biological features of hormonal resistance are limited by the lack of adequate preclinical models. The aim of this study is to establish and characterize a panel of primary human luminal breast carcinoma xenografts, and to evaluate their response to endocrine therapies. Four hundred and twenty-three tumor fragments obtained directly from patients have been grafted in the interscapular fatpad of Swiss nude mice. After stable engraftment with estradiol supplementation, xenografted tumors have been validated by conventional pathology and immunohistochemistry examination, and additional molecular studies. In vivo tumor growth and response to different endocrine treatments were evaluated. We have engrafted 423 tumors including 314 ER+ tumors, and 8 new luminal breast cancer xenografts have been obtained (2.5%). Tumor take was much lower for luminal tumors than for non-luminal tumors (2.5 vs. 24.7%, P < 0.0001), and was associated with two independent criteria, i.e., ER status (P < 0.0001) and a high grade tumor (P = 0.05). Histological and immunohistochemical analyses performed on patient's tumors and xenografts showed striking similarities in the tumor morphology as well as in the expression level of ER, PR, and HER2. Response to hormone therapy, evaluated in 6 luminal models, showed different sensitivities, thus exhibiting heterogeneity similar to what is observed in the clinic. We have established a panel of primary human luminal breast cancer xenografts, recapitulating the biological and clinical behaviors of patient tumors, and therefore suitable for further preclinical experiments. PMID:22002565

  18. Detection of aberrant methylation of a six-gene panel in serum DNA for diagnosis of breast cancer.

    Science.gov (United States)

    Shan, Ming; Yin, Huizi; Li, Junnan; Li, Xiaobo; Wang, Dong; Su, Yonghui; Niu, Ming; Zhong, Zhenbin; Wang, Ji; Zhang, Xianyu; Kang, Wenli; Pang, Da

    2016-04-01

    Detection of breast cancer at an early stage is the key for successful treatment and improvement of outcome. However the limitations of mammography are well recognized, especially for those women with premenopausal breast cancer. Novel approaches to breast cancer screening are necessary, especially in the developing world where mammography is not feasible. In this study, we examined the promoter methylation of six genes (SFN, P16, hMLH1, HOXD13, PCDHGB7 and RASSF1a) in circulating free DNA (cfDNA) extracted from serum. We used a high-throughput DNA methylation assay (MethyLight) to examine serum from 749 cases including breast cancer patients, patients with benign breast diseases and healthy women. The six-gene methylation panel test achieved 79.6% and 82.4% sensitivity with a specificity of 72.4% and 78.1% in diagnosis of breast cancer when compared with healthy and benign disease controls, respectively. Moreover, the methylation panel positive group showed significant differences in the following independent variables: (a) involvement of family history of tumors; (b) a low proliferative index, ki-67; (c) high ratios in luminal subtypes. Additionally the panel also complemented some breast cancer cases which were neglected by mammography or ultrasound. These data suggest that epigenetic markers in serum have potential for diagnosis of breast cancer. PMID:26918343

  19. Using panel econometric methods to estimate the effect of milk consumption on the mortality rate of prostate and ovarian cancer

    OpenAIRE

    Hagen, Tobias; Waldeck, Stefanie

    2014-01-01

    Recently prostate and ovarian cancer has been related to milk consumption. However, existing observational studies based on country level data do not attempt to identify causal effects since they are only based on simple cross-sectional analyses. This paper takes a step toward estimating of causal effects of milk consumption on cancer by applying panel econometric models and by using the within-country variation of the mortality rates and food consumption instead of the between-country variat...

  20. American Society of Clinical Oncology policy statement update: genetic testing for cancer susceptibility.

    Science.gov (United States)

    2003-06-15

    As the leading organization representing cancer specialists involved in patient care and clinical research, the American Society of Clinical Oncology (ASCO) reaffirms its commitment to integrating cancer risk assessment and management, including molecular analysis of cancer predisposition genes, into the practice of oncology and preventive medicine. The primary goal of this effort is to foster expanded access to, and continued advances in, medical care provided to patients and families affected by hereditary cancer syndromes. The 1996 ASCO Statement on Genetic Testing for Cancer Susceptibility set forth specific recommendations relating to clinical practice, research needs, educational opportunities, requirement for informed consent, indications for genetic testing, regulation of laboratories, and protection from discrimination, as well as access to and reimbursement for cancer genetics services. In updating this Statement, ASCO endorses the following principles: Indications for Genetic Testing: ASCO recommends that genetic testing be offered when 1) the individual has personal or family history features suggestive of a genetic cancer susceptibility condition, 2) the test can be adequately interpreted, and 3) the results will aid in diagnosis or influence the medical or surgical management of the patient or family members at hereditary risk of cancer. ASCO recommends that genetic testing only be done in the setting of pre- and post-test counseling, which should include discussion of possible risks and benefits of cancer early detection and prevention modalities. Special Issues in Testing Children for Cancer Susceptibility: ASCO recommends that the decision to offer testing to potentially affected children should take into account the availability of evidence-based risk-reduction strategies and the probability of developing a malignancy during childhood. Where risk-reduction strategies are available or cancer predominantly develops in childhood, ASCO believes that

  1. A panel of genes methylated with high frequency in colorectal cancer

    International Nuclear Information System (INIS)

    The development of colorectal cancer (CRC) is accompanied by extensive epigenetic changes, including frequent regional hypermethylation particularly of gene promoter regions. Specific genes, including SEPT9, VIM1 and TMEFF2 become methylated in a high fraction of cancers and diagnostic assays for detection of cancer-derived methylated DNA sequences in blood and/or fecal samples are being developed. There is considerable potential for the development of new DNA methylation biomarkers or panels to improve the sensitivity and specificity of current cancer detection tests. Combined epigenomic methods – activation of gene expression in CRC cell lines following DNA demethylating treatment, and two novel methods of genome-wide methylation assessment – were used to identify candidate genes methylated in a high fraction of CRCs. Multiplexed amplicon sequencing of PCR products from bisulfite-treated DNA of matched CRC and non-neoplastic tissue as well as healthy donor peripheral blood was performed using Roche 454 sequencing. Levels of DNA methylation in colorectal tissues and blood were determined by quantitative methylation specific PCR (qMSP). Combined analyses identified 42 candidate genes for evaluation as DNA methylation biomarkers. DNA methylation profiles of 24 of these genes were characterised by multiplexed bisulfite-sequencing in ten matched tumor/normal tissue samples; differential methylation in CRC was confirmed for 23 of these genes. qMSP assays were developed for 32 genes, including 15 of the sequenced genes, and used to quantify methylation in tumor, adenoma and non-neoplastic colorectal tissue and from healthy donor peripheral blood. 24 of the 32 genes were methylated in >50% of neoplastic samples, including 11 genes that were methylated in 80% or more CRCs and a similar fraction of adenomas. This study has characterised a panel of 23 genes that show elevated DNA methylation in >50% of CRC tissue relative to non-neoplastic tissue. Six of these genes

  2. A Panel of Cancer Testis Antigens and Clinical Risk Factors to Predict Metastasis in Colorectal Cancer

    Directory of Open Access Journals (Sweden)

    Ramyar Molania

    2014-01-01

    Full Text Available Colorectal cancer (CRC is the third common carcinoma with a high rate of mortality worldwide and several studies have investigated some molecular and clinicopathological markers for diagnosis and prognosis of its malignant phenotypes. The aim of this study is to evaluate expression frequency of PAGE4, SCP-1, and SPANXA/D cancer testis antigen (CTA genes as well as some clinical risk markers to predict liver metastasis of colorectal cancer patients. The expression frequency of PAGE4, SCP-1, and SPANXA/D cancer/testis antigen (CTA genes was obtained using reverse transcription polymerase chain reaction (RT-PCR assay in 90 colorectal tumor samples including both negative and positive liver metastasis tumors. Statistical analysis was performed to assess the association of three studied genes and clinical risk factors with CRC liver metastasis. The frequency of PAGE4 and SCP-1 genes expression was significantly higher in the primary tumours with liver metastasis when statistically compared with primary tumors with no liver metastasis (P<0.05. Among all clinical risk factors studied, the lymph node metastasis and the depth of invasion were statistically correlated with liver metastasis of CRC patients. In addition, using multiple logistic regression, we constructed a model based on PAGE4 and lymph node metastasis to predict liver metastasis of CRC.

  3. Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure

    Science.gov (United States)

    vom Saal, Frederick S.; Akingbemi, Benson T.; Belcher, Scott M.; Birnbaum, Linda S.; Crain, D. Andrew; Eriksen, Marcus; Farabollini, Francesca; Guillette, Louis J., Jr.; Hauser, Russ; Heindel, Jerrold J.; Ho, Shuk-Mei; Hunt, Patricia A.; Iguchi, Taisen; Jobling, Susan; Kanno, Jun; Keri, Ruth A.; Knudsen, Karen E.; Laufer, Hans; LeBlanc, Gerald A.; Marcus, Michele; McLachlan, John A.; Myers, John Peterson; Nadal, Angel; Newbold, Retha R.; Olea, Nicolas; Prins, Gail S.; Richter, Catherine A.; Rubin, Beverly S.; Sonnenschein, Carlos; Soto, Ana M.; Talsness, Chris E.; Vandenbergh, John G.; Vanderberg, Laura N.; Walser-Kuntz, Debby R.; Watson, Cheryl S.; Welshons, Wade V.; Wetherill, Yelena; Zoeller, R. Thomas

    2007-01-01

    This document is a summary statement of the outcome from the meeting: “Bisphenol A: An Examination of the Relevance of Ecological, In vitro and Laboratory Animal Studies for Assessing Risks to Human Health” sponsored by both the NIEHS and NIDCR at NIH/DHHS, as well as the US-EPA and Commonweal on the estrogenic environmental chemical bisphenol A (BPA, 2,2-bis(4-hydroxyphenyl)propane; CAS# 80-05-7). The meeting was held in Chapel Hill, NC, 28–30 November 2006 due to concerns about the potential for a relationship between BPA and negative trends in human health that have occurred in recent decades. Examples include increases in abnormal penile/urethra development in males, early sexual maturation in females, an increase in neurobehavioral problems such as attention deficit hyperactivity disorder (ADHD) and autism, an increase in childhood and adult obesity and type 2 diabetes, a regional decrease in sperm count, and an increase in hormonally mediated cancers, such as prostate and breast cancers. Concern has been elevated by published studies reporting a relationship between treatment with “low doses” of BPA and many of theses negative health outcomes in experimental studies in laboratory animals as well as in vitro studies identifying plausible molecular mechanisms that could mediate such effects. Importantly, much evidence suggests that these adverse effects are occurring in animals within the range of exposure to BPA of the typical human living in a developed country, where virtually everyone has measurable blood, tissue and urine levels of BPA that exceed the levels produced by doses used in the “low dose” animal experiments.

  4. Toward development of a surface-enhanced Raman scattering (SERS)-based cancer diagnostic immunoassay panel.

    Science.gov (United States)

    Granger, Jennifer H; Granger, Michael C; Firpo, Matthew A; Mulvihill, Sean J; Porter, Marc D

    2013-01-21

    Proteomic analyses of readily obtained human fluids (e.g., serum, urine, and saliva) indicate that the diagnosis of complex diseases will be enhanced by the simultaneous measurement of multiple biomarkers from such samples. This paper describes the development of a nanoparticle-based multiplexed platform that has the potential for simultaneous read-out of large numbers of biomolecules. For this purpose, we have chosen pancreatic adenocarcinoma (PA) as a test bed for diagnosis and prognosis. PA is a devastating form of cancer in which an estimated 86% of diagnoses resulted in death in the United States in 2010. The high mortality rate is due, in part, to the asymptomatic development of the disease and the dearth of sensitive diagnostics available for early detection. One promising route lies in the development of a serum biomarker panel that can generate a signature unique to early stage PA. We describe the design and development of a proof-of-concept PA biomarker immunoassay array coupled with surface-enhanced Raman scattering (SERS) as a sensitive readout method. PMID:23150876

  5. Expert consensus statement on diagnosis and treatment of cancer-related depressed mood state based on Chinese medicine

    Directory of Open Access Journals (Sweden)

    Shaodan Tian

    2015-10-01

    Full Text Available This consensus statement is organized into six parts: 1 Definitions: cancer-related depressed mood state is defined as a group of depressive symptoms, rather than major depressive disorder. Thus, “cancer-related depression” or “depressed mood state” is introduced as standard terminology and associated with the Chinese medicine concept of “yu zheng” (depression syndrome. 2 Pathogenesis: factors including psychological stress, cancer pain, cancer fatigue, sleep disorders, surgery trauma, chemotherapy, and radiation therapy are strongly associated with cancer-related depressed mood state. Crucial elements of pathogenesis are cancer caused by depression, depression caused by cancer, and the concurrence of phlegm, dampness, and stasis from constrained liver-qi and spleen deficiency. 3 Symptoms: these include core symptoms, psychological symptoms, and somatic symptoms. Depressed mood and loss of interest are the main criteria for diagnosis. 4 Clinical evaluation: based on the Mini-International Neuropsychiatric Interview and a numeric rating scale, and taking mood changes during cancer diagnosis and treatment into consideration, a questionnaire can be drafted to distinguish between major depressive disorder and cancer-related depression. The aim is to assist oncology clinicians to identify, treat, and refer patients with cancer-related depression. 5 Diagnosis: diagnosis should be based on the Chinese Classification for Mental Disorders (CCMD-3, taking patients' mood changes during diagnosis and treatment into consideration. 6 Treatment: treatments for cancer-related depression must be performed concurrently with cancer treatment. For mild depression, non-pharmacologic comprehensive therapies, including psychological intervention, music therapy, patient education, physical activity, and acupuncture, are recommended; for moderate depression, classical Chinese herbal formulas based on syndrome pattern differentiation combined with

  6. Attitudes and Stereotypes in Lung Cancer versus Breast Cancer.

    Science.gov (United States)

    Sriram, N; Mills, Jennifer; Lang, Edward; Dickson, Holli K; Hamann, Heidi A; Nosek, Brian A; Schiller, Joan H

    2015-01-01

    Societal perceptions may factor into the high rates of nontreatment in patients with lung cancer. To determine whether bias exists toward lung cancer, a study using the Implicit Association Test method of inferring subconscious attitudes and stereotypes from participant reaction times to visual cues was initiated. Participants were primarily recruited from an online survey panel based on US census data. Explicit attitudes regarding lung and breast cancer were derived from participants' ratings (n = 1778) regarding what they thought patients experienced in terms of guilt, shame, and hope (descriptive statements) and from participants' opinions regarding whether patients ought to experience such feelings (normative statements). Participants' responses to descriptive and normative statements about lung cancer were compared with responses to statements about breast cancer. Analyses of responses revealed that the participants were more likely to agree with negative descriptive and normative statements about lung cancer than breast cancer (Plung cancer compared with breast cancer; mean response times in the lung cancer/negative conditions were significantly shorter than in the lung cancer/positive conditions (Pcaregivers, healthcare providers, and members of the general public had comparable levels of negative implicit attitudes toward lung cancer. These results show that lung cancer was stigmatized by patients, caregivers, healthcare professionals, and the general public. Further research is needed to investigate whether implicit and explicit attitudes and stereotypes affect patient care. PMID:26698307

  7. Attitudes and Stereotypes in Lung Cancer versus Breast Cancer.

    Directory of Open Access Journals (Sweden)

    N Sriram

    Full Text Available Societal perceptions may factor into the high rates of nontreatment in patients with lung cancer. To determine whether bias exists toward lung cancer, a study using the Implicit Association Test method of inferring subconscious attitudes and stereotypes from participant reaction times to visual cues was initiated. Participants were primarily recruited from an online survey panel based on US census data. Explicit attitudes regarding lung and breast cancer were derived from participants' ratings (n = 1778 regarding what they thought patients experienced in terms of guilt, shame, and hope (descriptive statements and from participants' opinions regarding whether patients ought to experience such feelings (normative statements. Participants' responses to descriptive and normative statements about lung cancer were compared with responses to statements about breast cancer. Analyses of responses revealed that the participants were more likely to agree with negative descriptive and normative statements about lung cancer than breast cancer (P<0.001. Furthermore, participants had significantly stronger implicit negative associations with lung cancer compared with breast cancer; mean response times in the lung cancer/negative conditions were significantly shorter than in the lung cancer/positive conditions (P<0.001. Patients, caregivers, healthcare providers, and members of the general public had comparable levels of negative implicit attitudes toward lung cancer. These results show that lung cancer was stigmatized by patients, caregivers, healthcare professionals, and the general public. Further research is needed to investigate whether implicit and explicit attitudes and stereotypes affect patient care.

  8. Expert Panel Reaffirms Need for Colon Cancer Screen Beginning At Age 50

    Science.gov (United States)

    ... key, because a positive stool test plus stool DNA test (such as Cologuard), or a positive imaging test ( ... blood in stool); and the recently approved Cologuard DNA-based stool test. The panel said there were no comparison studies ...

  9. Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer

    OpenAIRE

    Laird Peter W; Weisenberger Daniel J; Campan Mihaela; Turla Sally; Hagen Jeffrey A; Koss Michael N; Galler Janice S; Anglim Paul P; Siegmund Kimberly D; Laird-Offringa Ite A

    2008-01-01

    Abstract Background Lung cancer is the leading cause of cancer death in men and women in the United States and Western Europe. Over 160,000 Americans die of this disease every year. The five-year survival rate is 15% – significantly lower than that of other major cancers. Early detection is a key factor in increasing lung cancer patient survival. DNA hypermethylation is recognized as an important mechanism for tumor suppressor gene inactivation in cancer and could yield powerful biomarkers fo...

  10. Statement on the comments by Hattingh et al. (2014) on the EFSA PLH Panel (2014) Scientific Opinion on Citrus Black Spot

    OpenAIRE

    EFSA Panel on Plant Health (PLH)

    2015-01-01

    Following a request from the European Commission, the EFSA Panel on Plant Health (EFSA PLH Panel) was asked to react to a document entitled “Comments on the European Union Food Safety Authority’s Pest Risk Assessment for Phyllosticta citricarpa”, authored by Hattingh et al., which was posted online in August 2014 on the website of Citrus Research International (Pty) Ltd, South Africa. Citrus black spot (CBS), caused by the fungus Phyllosticta citricarpa (McAlpine) Van der Aa, is a fruit-blemi...

  11. A three-protein biomarker panel assessed in diagnostic tissue predicts death from prostate cancer for men with localized disease

    International Nuclear Information System (INIS)

    Only a minority of prostate cancers lead to death. Because no tissue biomarkers of aggressiveness other than Gleason score are available at diagnosis, many nonlethal cancers are treated aggressively. We evaluated whether a panel of biomarkers, associated with a range of disease outcomes in previous studies, could predict death from prostate cancer for men with localized disease. Using a case-only design, subjects were identified from three Australian epidemiological studies. Men who had died of their disease, “cases” (N = 83), were matched to “referents” (N = 232), those who had not died of prostate cancer, using incidence density sampling. Diagnostic tissue was retrieved to assess expression of AZGP1, MUC1, NKX3.1, p53, and PTEN by semiquantitative immunohistochemistry (IHC). Poisson regression was used to estimate mortality rate ratios (MRRs) adjusted for age, Gleason score, and stage and to estimate survival probabilities. Expression of MUC1 and p53 was associated with increased mortality (MRR 2.51, 95% CI 1.14–5.54, P = 0.02 and 3.08, 95% CI 1.41–6.95, P = 0.005, respectively), whereas AZGP1 expression was associated with decreased mortality (MRR 0.44, 95% CI 0.20–0.96, P = 0.04). Analyzing all markers under a combined model indicated that the three markers were independent predictors of prostate cancer death and survival. For men with localized disease at diagnosis, assessment of AZGP1, MUC1, and p53 expression in diagnostic tissue by IHC could potentially improve estimates of risk of dying from prostate cancer based only on Gleason score and clinical stage

  12. American Society of Clinical Oncology policy statement: opportunities in the patient protection and affordable care act to reduce cancer care disparities.

    Science.gov (United States)

    Moy, Beverly; Polite, Blase N; Halpern, Michael T; Stranne, Steven K; Winer, Eric P; Wollins, Dana S; Newman, Lisa A

    2011-10-01

    Patients in specific vulnerable population groups suffer disproportionately from cancer. The elimination of cancer disparities is critically important for lessening the burden of cancer. The Patient Protection and Affordable Care Act provides both opportunities and challenges for addressing cancer care disparities and access to care. The American Society of Clinical Oncology (ASCO) advocates for policies that ensure access to cancer care for the underserved. Such policies include insurance reform and the reduction of economic barriers to quality health care. Building on ASCO's prior statement on disparities in cancer care (2009), this article summarizes elements of the health care law that are relevant to cancer disparities and provides recommendations for addressing major provisions in the law. It outlines specific strategies to address insurance reform, access to care, quality of care, prevention and wellness, research on health care disparities, and diversity in the health care workforce. ASCO is committed to leading efforts toward the improvement of cancer care among the most vulnerable patients. PMID:21810680

  13. Gene expression changes as markers of early lapatinib response in a panel of breast cancer cell lines

    Directory of Open Access Journals (Sweden)

    O’Neill Fiona

    2012-06-01

    Full Text Available Abstract Background Lapatinib, a tyrosine kinase inhibitor of HER2 and EGFR and is approved, in combination with capecitabine, for the treatment of trastuzumab-refractory metastatic breast cancer. In order to establish a possible gene expression response to lapatinib, a panel of breast cancer cell lines with varying sensitivity to lapatinib were analysed using a combination of microarray and qPCR profiling. Methods Co-inertia analysis (CIA, a data integration technique, was used to identify transcription factors associated with the lapatinib response on a previously published dataset of 96 microarrays. RNA was extracted from BT474, SKBR3, EFM192A, HCC1954, MDAMB453 and MDAMB231 breast cancer cell lines displaying a range of lapatinib sensitivities and HER2 expression treated with 1 μM of lapatinib for 12 hours and quantified using Taqman RT-PCR. A fold change ≥ ± 2 was considered significant. Results A list of 421 differentially-expressed genes and 8 transcription factors (TFs whose potential regulatory impact was inferred in silico, were identified as associated with lapatinib response. From this group, a panel of 27 genes (including the 8 TFs were selected for qPCR validation. 5 genes were determined to be significantly differentially expressed following the 12 hr treatment of 1 μM lapatinib across all six cell lines. Furthermore, the expression of 4 of these genes (RB1CC1, FOXO3A, NR3C1 and ERBB3 was directly correlated with the degree of sensitivity of the cell line to lapatinib and their expression was observed to “switch” from up-regulated to down-regulated when the cell lines were arranged in a lapatinib-sensitive to insensitive order. These included the novel lapatinib response-associated genes RB1CC1 and NR3C1. Additionally, Cyclin D1 (CCND1, a common regulator of the other four proteins, was also demonstrated to observe a proportional response to lapatinib exposure. Conclusions A panel of 5 genes were determined to

  14. Gene expression changes as markers of early lapatinib response in a panel of breast cancer cell lines

    LENUS (Irish Health Repository)

    O’Neill, Fiona

    2012-06-18

    AbstractBackgroundLapatinib, a tyrosine kinase inhibitor of HER2 and EGFR and is approved, in combination with capecitabine, for the treatment of trastuzumab-refractory metastatic breast cancer. In order to establish a possible gene expression response to lapatinib, a panel of breast cancer cell lines with varying sensitivity to lapatinib were analysed using a combination of microarray and qPCR profiling.MethodsCo-inertia analysis (CIA), a data integration technique, was used to identify transcription factors associated with the lapatinib response on a previously published dataset of 96 microarrays. RNA was extracted from BT474, SKBR3, EFM192A, HCC1954, MDAMB453 and MDAMB231 breast cancer cell lines displaying a range of lapatinib sensitivities and HER2 expression treated with 1 μM of lapatinib for 12 hours and quantified using Taqman RT-PCR. A fold change ≥ ± 2 was considered significant.ResultsA list of 421 differentially-expressed genes and 8 transcription factors (TFs) whose potential regulatory impact was inferred in silico, were identified as associated with lapatinib response. From this group, a panel of 27 genes (including the 8 TFs) were selected for qPCR validation. 5 genes were determined to be significantly differentially expressed following the 12 hr treatment of 1 μM lapatinib across all six cell lines. Furthermore, the expression of 4 of these genes (RB1CC1, FOXO3A, NR3C1 and ERBB3) was directly correlated with the degree of sensitivity of the cell line to lapatinib and their expression was observed to “switch” from up-regulated to down-regulated when the cell lines were arranged in a lapatinib-sensitive to insensitive order. These included the novel lapatinib response-associated genes RB1CC1 and NR3C1. Additionally, Cyclin D1 (CCND1), a common regulator of the other four proteins, was also demonstrated to observe a proportional response to lapatinib exposure.ConclusionsA panel of 5 genes were determined to be differentially

  15. The International Association for the Study of Lung Cancer Consensus Statement on Optimizing Management of EGFR Mutation-Positive Non-Small Cell Lung Cancer: Status in 2016.

    Science.gov (United States)

    Tan, Daniel S W; Yom, Sue S; Tsao, Ming S; Pass, Harvey I; Kelly, Karen; Peled, Nir; Yung, Rex C; Wistuba, Ignacio I; Yatabe, Yasushi; Unger, Michael; Mack, Philip C; Wynes, Murry W; Mitsudomi, Tetsuya; Weder, Walter; Yankelevitz, David; Herbst, Roy S; Gandara, David R; Carbone, David P; Bunn, Paul A; Mok, Tony S K; Hirsch, Fred R

    2016-07-01

    Mutations in the epidermal growth factor receptor gene (EGFR) represent one of the most frequent "actionable" alterations in non-small cell lung cancer (NSCLC). Typified by high response rates to targeted therapies, EGFR tyrosine kinase inhibitors (TKIs) are now established first-line treatment options and have transformed the treatment paradigm for NSCLC. With the recent breakthrough designation and approval of the third-generation EGFR TKI osimertinib, available systemic and local treatment options have expanded, requiring new clinical algorithms that take into account individual patient molecular and clinical profiles. In this International Association for the Study of Lung Cancer commissioned consensus statement, key pathologic, diagnostic, and therapeutic considerations, such as optimal choice of EGFR TKI and management of brain metastasis, are discussed. In addition, recommendations are made for clinical guidelines and research priorities, such as the role of repeat biopsies and use of circulating free DNA for molecular studies. With the rapid pace of progress in treating EGFR-mutant NSCLC, this statement provides a state-of-the-art review of the contemporary issues in managing this unique subgroup of patients. PMID:27229180

  16. Identification of variants in primary and recurrent glioblastoma using a cancer-specific gene panel and whole exome sequencing.

    Directory of Open Access Journals (Sweden)

    Selene M Virk

    Full Text Available Glioblastoma (GBM is an aggressive, malignant brain tumor typically resulting in death of the patient within one year following diagnosis; and those who survive beyond this point usually present with tumor recurrence within two years (5-year survival is 5%. The genetic heterogeneity of GBM has made the molecular characterization of these tumors an area of great interest and has led to identification of molecular subtypes in GBM. The availability of sequencing platforms that are both fast and economical can further the adoption of tumor sequencing in the clinical environment, potentially leading to identification of clinically actionable genetic targets. In this pilot study, comprised of triplet samples of normal blood, primary tumor, and recurrent tumor samples from three patients; we compared the ability of Illumina whole exome sequencing (ExomeSeq and the Ion AmpliSeq Comprehensive Cancer Panel (CCP to identify somatic variants in patient-paired primary and recurrent tumor samples. Thirteen genes were found to harbor variants, the majority of which were exclusive to the ExomeSeq data. Surprisingly, only two variants were identified by both platforms and they were located within the PTCH1 and NF1 genes. Although preliminary in nature, this work highlights major differences in variant identification in data generated from the two platforms. Additional studies with larger samples sizes are needed to further explore the differences between these technologies and to enhance our understanding of the clinical utility of panel based platforms in genomic profiling of brain tumors.

  17. Development and analytical validation of a 25-gene next generation sequencing panel that includes the BRCA1 and BRCA2 genes to assess hereditary cancer risk

    OpenAIRE

    Judkins, Thaddeus; Leclair, Benoît; Bowles, Karla; Gutin, Natalia; Trost, Jeff; McCulloch, James; Bhatnagar, Satish; Murray, Adam; Craft, Jonathan; Wardell, Bryan; Bastian, Mark; Mitchell, Jeffrey; Jian CHEN; Tran, Thanh; Williams, Deborah

    2015-01-01

    Background Germline DNA mutations that increase the susceptibility of a patient to certain cancers have been identified in various genes, and patients can be screened for mutations in these genes to assess their level of risk for developing cancer. Traditional methods using Sanger sequencing focus on small groups of genes and therefore are unable to screen for numerous genes from several patients simultaneously. The goal of the present study was to validate a 25-gene panel to assess genetic r...

  18. COMARE statement: investigation of the incidence of cancer around Wylfa and Trawsfyndd nuclear installations

    Energy Technology Data Exchange (ETDEWEB)

    Redwood, J.A.

    1994-06-16

    In answer to a House of Commons question, this piece from Hansard for 16th June 1994 looks at the incidence of cancer around the Trawsfynydd and Wylfa nuclear installations in Wales. A study undertaken between 1974 and 1986 followed groupings of many cancers, especially leukaemias, lymphoid leukaemia, lymphomas, Hodgkin's disease, multiple myeloma, brain and thyroid cancers. These were chosen because of their suggested links with radiation in the medical literature. No statistically significant links were found between the incidence of cancers studied and residence near the nuclear stations. (UK).

  19. A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses.

    Directory of Open Access Journals (Sweden)

    Ville Härmä

    Full Text Available Prostate epithelial cells from both normal and cancer tissues, grown in three-dimensional (3D culture as spheroids, represent promising in vitro models for the study of normal and cancer-relevant patterns of epithelial differentiation. We have developed the most comprehensive panel of miniaturized prostate cell culture models in 3D to date (n = 29, including many non-transformed and most currently available classic prostate cancer (PrCa cell lines. The purpose of this study was to analyze morphogenetic properties of PrCa models in 3D, to compare phenotypes, gene expression and metabolism between 2D and 3D cultures, and to evaluate their relevance for pre-clinical drug discovery, disease modeling and basic research. Primary and non-transformed prostate epithelial cells, but also several PrCa lines, formed well-differentiated round spheroids. These showed strong cell-cell contacts, epithelial polarization, a hollow lumen and were covered by a complete basal lamina (BL. Most PrCa lines, however, formed large, poorly differentiated spheroids, or aggressively invading structures. In PC-3 and PC-3M cells, well-differentiated spheroids formed, which were then spontaneously transformed into highly invasive cells. These cell lines may have previously undergone an epithelial-to-mesenchymal transition (EMT, which is temporarily suppressed in favor of epithelial maturation by signals from the extracellular matrix (ECM. The induction of lipid and steroid metabolism, epigenetic reprogramming, and ECM remodeling represents a general adaptation to 3D culture, regardless of transformation and phenotype. In contrast, PI3-Kinase, AKT, STAT/interferon and integrin signaling pathways were particularly activated in invasive cells. Specific small molecule inhibitors targeted against PI3-Kinase blocked invasive cell growth more effectively in 3D than in 2D monolayer culture, or the growth of normal cells. Our panel of cell models, spanning a wide spectrum of phenotypic

  20. Thyroid cancer in children living near Chernobyl. Expert panel report on the consequences of the Chernobyl accident

    International Nuclear Information System (INIS)

    In January 1992, the Radiation Protection Research Action formed a panel of thyroid experts in order to evaluate the current situation concerning reported increased rates of thyroid cancer in children living in the neighbourhood of Chernobyl, where the reactor accident occurred on April 26 1986 and resulted in widespread radioactive contamination over large areas of Belarus, Russia, Ukraine. Studies of the Atom Bomb survivors in Japan have revealed that the incidence of leukemia starts to increase some five years after exposure. For Chernobyl accident health consequences are now becoming evident. Thyroid cancer has already been observed in children. Iodine 131 was seen to pose a specific hazard because it is taken up by the body and concentrated in the thyroid gland. At a dose of 5 Gy to the childhood thyroid about 4000 thyroid cancers per 100000 children exposed can be anticipated. An essential component of the verification of this observation is the study of the pathology of the lesions, which derived from four cell types: follicular cells, C cells, lymphoid cells and connective tumor cells. All distant metastases are lung metastases. Measures to be considered for the prevention of the development of thyroid cancer in a radiation-exposed population include correction of iodine deficiency by iodine prophylaxis and suppression of TSH. There are three methods of diagnosis: ultrasound imaging, thyroid scanning, fine needle aspiration performed by skilled personnel. For the therapy total or near-total thyroidectomy is regarded as the treatment of choice. Radioactive iodine can be used to treat lymph node and distant metastases which take up iodine after a total thyroidectomy. Thyroid hormone replacement should be carried out with TSH suppressive doses of L-Thyroxine. 45 refs., 1 annexe

  1. [Nationwide statements from regional data: methods of the Center for Cancer Registry Data].

    Science.gov (United States)

    Kraywinkel, K; Barnes, B; Dahm, S; Haberland, J; Nennecke, A; Stabenow, R

    2014-01-01

    Despite having achieved nationwide registry coverage in addition to substantial improvements in data on the epidemiology of cancer in Germany, the Centre for Cancer Registry Data continues to estimate national statistics on incidence, survival, and prevalence instead of calculating these directly from available data. The methods used for evaluations are based initially on estimates of registration completeness or, for survival analyses, an assessment of the quality of follow-up data. The completeness of incident case registration is estimated on the basis of the mortality/incidence procedure, which assumes a largely constant relationship between the mortality and incidence of a cancer type among people of the same age and sex across federal states. Inclusion criteria for consideration of registry data in national survival analyses are less than 15% of death certificate only (DCO) cases and plausible survival for patients with pancreatic cancer or metastatic lung cancer. Of the 477,300 incident cancer cases estimated for 2010, 429,900 were reported by the cancer registries (90%), and ten federal states contributed data to national survival estimates. PMID:24357167

  2. A novel proteomic biomarker panel as a diagnostic tool for patients with ovarian cancer

    DEFF Research Database (Denmark)

    Høgdall, Claus; Fung, Eric T; Christensen, Ib J;

    2011-01-01

    Previous reports have shown that the proteomic markers apolipoprotein A1, hepcidin, transferrin, inter-alpha trypsin IV internal fragment, transthyretin, connective-tissue activating protein 3 and beta-2 microglobulin may discriminate between a benign pelvic mass and ovarian cancer (OC). The aim...

  3. Long-term survivors of childhood cancer: Cure and care. The Erice Statement

    OpenAIRE

    Haupt, R; Spinetta, J.J.; Ban, I.; Barr, R.G.; Beck, J.D.; Byrne, J; Calaminus, G; Coenen, E.; Chesler, M; Angio, d', G.J.; Eiser, C.; Feldges, A; Gibson, F.; Lackner, H.; Masera, G.

    2009-01-01

    The number of individuals who have successfully completed treatment for a cancer diagnosed during childhood and are entering adulthood has been increasing. Members of the International Berlin-Frankfurt-Munster Early and Late Toxicity Educational Committee (ELTEC) invited 45 paediatric cancer experts - representing oncologists, psychologists, nurses, epidemiologists, parents, and survivors - from 13 European countries, with five additional experts from North America, to Erice, Sicily, on Octob...

  4. Advances in Treating Metastatic Bone Cancer: Summary Statement for the First Cambridge Conference

    OpenAIRE

    Lipton, Allan; Berenson, James R; Body, Jean-Jacques; Boyce, Brendan F.; Bruland, Oyvind S.; Carducci, Michael A; Cleeland, Charles S.; Clohisy, Denis R.; Coleman, Robert E.; Cook, Richard J.; Guise, Theresa A.; Pearse, Roger N.; Powles, Trevor J; Rogers, Michael J; Roodman, G. David

    2006-01-01

    The First Cambridge Conference on Advances in Treating Metastatic Bone Cancer, a symposium held in Cambridge, Massachusetts, October 28 to 29, 2005, was convened to discuss recent advances and research related to the natural history of bone metastases and skeletal complications, bone cancer biology, treatment of myeloma and other solid tumors, and treatment-induced bone loss. The conference format combined brief presentations with extended periods of discussion. The conclusions reached during...

  5. Global microRNA analysis of the NCI-60 cancer cell panel

    DEFF Research Database (Denmark)

    Søkilde, Rolf; Kaczkowski, Bogumil; Podolska, Agnieszka;

    2011-01-01

    progression of cancer, they comprise a novel class of promising diagnostic and prognostic molecular markers and potential drug targets. By applying an LNA-enhanced microarray platform, we studied the expression profiles of 955 miRNAs in the NCI-60 cancer cell lines and identified tissue- and cell...... contributes expression data for 369 miRNAs that have not previously been profiled. Finally, by matching drug sensitivity data for the NCI-60 cells to their miRNA expression profiles, we found numerous drug-miRNAs pairs, for which the miRNA expression and drug sensitivity profiles were highly correlated and...... thus represent potential candidates for further investigation of drug resistance and sensitivity mechanisms....

  6. An individual with both MUTYH-associated polyposis and Lynch syndrome identified by multi-gene hereditary cancer panel testing: a case report

    Directory of Open Access Journals (Sweden)

    Stephanie A Cohen

    2016-03-01

    Full Text Available The utilization of next-generation sequencing technology to interrogate multiple genes simultaneously is being utilized more frequently in hereditary cancer testing. While this has benefits of reducing cost and allowing clinicians to cast a wide net in the elucidation of their patient’s cancer, panel testing has the potential to reveal unexpected information. We report on a proband with pathogenic variants resulting in two different hereditary colon cancer syndromes.A 39-year-old male with a history of colon cancer, more than 20 colon polyps and a family history of colon cancer presented for genetic counseling. Testing with a 7-gene high-risk hereditary colon cancer panel identified a homozygous pathogenic variant, c.1187G>A (p.Gly396Asp in MUTYH, and a likely pathogenic duplication of exon 7 in MSH2. Since this test result, the proband’s mother was diagnosed with colon cancer; subsequent genetic testing confirmed she also carries the likely pathogenic duplication in the MSH2 gene.Although the cancer risk in individuals who carry multiple pathogenic variants has not been established for combined biallelic MUTYH-associated polyposis and Lynch syndrome, the identification of multiple pathogenic variants does allow for screening for cancers associated with both syndromes and has implications for cancer risk for family members. In particular, this has significant impact on those who test negative for a known familial pathogenic variant, yet could be still be at risk for cancer due to a second pathogenic variant in a family. More information is needed on the frequency of occurrence of multiple pathogenic variants, as well as the phenotypic spectrum when multiple pathogenic variants are present.

  7. Society for immunotherapy of cancer (SITC) statement on the proposed changes to the common rule.

    Science.gov (United States)

    Kaufman, Howard L; Butterfield, Lisa H; Coulie, Pierre G; Demaria, Sandra; Ferris, Robert L; Galon, Jérôme; Khleif, Samir N; Mellman, Ira; Ohashi, Pamela S; Overwijk, Willem W; Topalian, Suzanne L; Marincola, Francesco M

    2016-01-01

    The Common Rule is a set of ethical principles that provide guidance on the management of human subjects taking part in biomedical and behavioral research in the United States. The elements of the Common Rule were initially developed in 1981 following a revision of the Declaration of Helsinki in 1975. Most academic facilities follow the Common Rule in the regulation of clinical trials research. Recently, the government has suggested a revision of the Common Rule to include more contemporary and streamlined oversight of clinical research. In this commentary, the leadership of the Society for Immunotherapy of Cancer (SITC) provides their opinion on this plan. While the Society recognizes the considerable contribution of clinical research in supporting progress in tumor immunotherapy and supports the need for revisions to the Common Rule, there is also some concern over certain elements which may restrict access to biospecimens and clinical data at a time when high throughput technologies, computational biology and assay standardization is allowing major advances in understanding cancer biology and providing potential predictive biomarkers of immunotherapy response. The Society values its professional commitment to patients for improving clinical outcomes with tumor immunotherapy and supports continued discussion with all stakeholders before implementing changes to the Common Rule in order to ensure maximal patient protections while promoting continued clinical research at this historic time in cancer research. PMID:27330810

  8. Locoregional surgical and interventional therapies for advanced colorectal cancer liver metastases: expert consensus statements.

    Science.gov (United States)

    Abdalla, Eddie K; Bauer, Todd W; Chun, Yun S; D'Angelica, Michael; Kooby, David A; Jarnagin, William R

    2013-02-01

    Selection of the optimal surgical and interventional therapies for advanced colorectal cancer liver metastases (CRLM) requires multidisciplinary discussion of treatment strategies early in the trajectory of the individual patient's care. This paper reports on expert consensus on locoregional and interventional therapies for the treatment of advanced CRLM. Resection remains the reference treatment for patients with bilateral CRLM and synchronous presentation of primary and metastatic cancer. Patients with oligonodular bilateral CRLM may be candidates for one-stage multiple segmentectomies; two-stage resection with or without portal vein embolization may allow complete resection in patients with more advanced disease. After downsizing with preoperative systemic and/or regional therapy, curative-intent hepatectomy requires resection of all initial and currently known sites of disease; debulking procedures are not recommended. Many patients with synchronous primary disease and CRLM can safely undergo simultaneous resection of all disease. Staged resections should be considered for patients in whom the volume of the future liver remnant is anticipated to be marginal or inadequate, who have significant medical comorbid condition(s), or in whom extensive resections are required for the primary cancer and/or CRLM. Priority for liver-first or primary-first resection should depend on primary tumour-related symptoms or concern for the progression of marginally resectable CRLM during treatment of the primary disease. Chemotherapy delivered by hepatic arterial infusion represents a valid option in patients with liver-only disease, although it is best delivered in experienced centres. Ablation strategies are not recommended as first-line treatments for resectable CRLM alone or in combination with resection because of high local failure rates and limitations related to tumour size, multiplicity and intrahepatic location. PMID:23297723

  9. A case-controlled validation study of a blood-based seven-gene biomarker panel for colorectal cancer in Malaysia

    Directory of Open Access Journals (Sweden)

    Yip Kok-Thye

    2010-09-01

    Full Text Available Abstract Background Colorectal cancer (CRC screening is key to CRC prevention and mortality reduction, but patient compliance with CRC screening is low. We previously reported a blood-based test for CRC that utilizes a seven-gene panel of biomarkers. The test is currently utilized clinically in North America for CRC risk stratification in the average-risk North American population in order to improve screening compliance and to enhance clinical decision making. Methods In this study, conducted in Malaysia, we evaluated the seven-gene biomarker panel validated in a North American population using blood samples collected from local patients. The panel employs quantitative RT-PCR (qRT-PCR to analyze gene expression of the seven biomarkers (ANXA3, CLEC4D, TNFAIP6, LMNB1, PRRG4, VNN1 and IL2RB that are differentially expressed in CRC patients as compared with controls. Blood samples from 210 patients (99 CRC and 111 controls were collected, and total blood RNA was isolated and subjected to quantitative RT-PCR and data analysis. Results The logistic regression analysis of seven-gene panel has an area under the curve (AUC of 0.76 (95% confidence interval: 0.70 to 0.82, 77% specificity, 61% sensitivity and 70% accuracy, comparable to the data obtained from the North American investigation of the same biomarker panel. Conclusions Our results independently confirm the results of the study conducted in North America and demonstrate the ability of the seven biomarker panel to discriminate CRC from controls in blood samples drawn from a Malaysian population.

  10. Panel Analysis

    DEFF Research Database (Denmark)

    Brænder, Morten; Andersen, Lotte Bøgh

    2014-01-01

    Based on our 2013-article, ”Does Deployment to War Affect Soldiers' Public Service Motivation – A Panel Study of Soldiers Before and After their Service in Afghanistan”, we present Panel Analysis as a methodological discipline. Panels consist of multiple units of analysis, observed at two or more...... in research settings where it is not possible to distribute units of analysis randomly or where the independent variables cannot be manipulated. The greatest disadvantage in regard to using panel studies is that data may be difficult to obtain. This is most clearly vivid in regard to the use of panel surveys...

  11. Oral toxicity management in head and neck cancer patients treated with chemotherapy and radiation: Xerostomia and trismus (Part 2). Literature review and consensus statement.

    Science.gov (United States)

    Buglione, Michela; Cavagnini, Roberta; Di Rosario, Federico; Maddalo, Marta; Vassalli, Lucia; Grisanti, Salvatore; Salgarello, Stefano; Orlandi, Ester; Bossi, Paolo; Majorana, Alessandra; Gastaldi, Giorgio; Berruti, Alfredo; Trippa, Fabio; Nicolai, Pietro; Barasch, Andrei; Russi, Elvio G; Raber-Durlacher, Judith; Murphy, Barbara; Magrini, Stefano M

    2016-06-01

    Radiotherapy alone or in combination with chemotherapy and/or surgery is a well-known radical treatment for head and neck cancer patients. Nevertheless acute side effects (such as moist desquamation, skin erythema, loss of taste, mucositis etc.) and in particular late toxicities (osteoradionecrosis, xerostomia, trismus, radiation caries etc.) are often debilitating and underestimated. A multidisciplinary group of head and neck cancer specialists from Italy met in Milan with the aim of reaching a consensus on a clinical definition and management of these toxicities. The Delphi Appropriateness method was used for this consensus and external experts evaluated the conclusions. The paper contains 20 clusters of statements about the clinical definition and management of stomatological issues that reached consensus, and offers a review of the literature about these topics. The review was split into two parts: the first part dealt with dental pathologies and osteo-radionecrosis (10 clusters of statements), whereas this second part deals with trismus and xerostomia (10 clusters of statements). PMID:27061883

  12. A simple immunohistochemical panel comprising 2 conventional markers, Ki67 and p53, is a powerful tool for predicting patient outcome in luminal-type breast cancer

    Directory of Open Access Journals (Sweden)

    Kobayashi Takayuki

    2013-02-01

    Full Text Available Abstract Background Ki67 is widely used in order to distinguish the “A” and “B” subtypes of luminal-type breast cancer. This study aimed to validate the prognostic value of adding p53 to Ki67 for characterizing luminal-type breast cancer. Methods Immunostaining for Ki67, p53, and the molecular markers HER2, CK5/6, CK14, EGFR, FOXA1, GATA3, and P-cadherin was examined hormone receptor (HR-positive cancer tissues from 150 patients. The prognostic value of an immunohistochemical panel comprising Ki67 and p53 was compared with that of the single Ki67 labeling index (LI, and uni- and multivariate analyses were performed. Results Division of the patients based on the immunohistochemistry results into favorable- (low Ki67 LI, p53-negative and unfavorable- (high Ki67 LI and/or p53-positive phenotype groups yielded distinctly different Kaplan-Meier's curves of both disease-free (PP=0.0007. These differences were much more distinct than those between the corresponding low Ki67 LI vs. high Ki67LI curves. While the prognostic values of the other molecular markers were not significant, combined Ki67-p53 status was an independent prognostic factor by multivariate analysis. Conclusion These data indicate that an immunohistochemical panel comprising Ki67 and p53 is a practical tool for management of patients with HR-positive breast cancer.

  13. Assessment of a six gene panel for the molecular detection of circulating tumor cells in the blood of female cancer patients

    International Nuclear Information System (INIS)

    The presence of circulating tumor cells (CTC) in the peripheral blood of cancer patients has been described for various solid tumors and their clinical relevance has been shown. CTC detection based on the analysis of epithelial antigens might be hampered by the genetic heterogeneity of the primary tumor and loss of epithelial antigens. Therefore, we aimed to identify new gene markers for the PCR-based detection of CTC in female cancer patients. Gene expression of 38 cancer cell lines (breast, ovarian, cervical and endometrial) and of 10 peripheral blood mononuclear cell (PBMC) samples from healthy female donors was measured using microarray technology (Applied Biosystems). Differentially expressed genes were identified using the maxT test and the 50% one-sided trimmed maxT-test. Confirmatory RT-qPCR was performed for 380 gene targets using the AB TaqMan® Low Density Arrays. Then, 93 gene targets were analyzed using the same RT-qPCR platform in tumor tissues of 126 patients with primary breast, ovarian or endometrial cancer. Finally, blood samples from 26 healthy women and from 125 patients (primary breast, ovarian, cervical, or endometrial cancer, and advanced breast cancer) were analyzed following OncoQuick enrichment and RNA pre-amplification. Likewise, hMAM and EpCAM gene expression was analyzed in the blood of breast and ovarian cancer patients. For each gene, a cut-off threshold value was set at three standard deviations from the mean expression level of the healthy controls to identify potential markers for CTC detection. Six genes were over-expressed in blood samples from 81% of patients with advanced and 29% of patients with primary breast cancer. EpCAM gene expression was detected in 19% and 5% of patients, respectively, whereas hMAM gene expression was observed in the advanced group (39%) only. Multimarker analysis using the new six gene panel positively identified 44% of the cervical, 64% of the endometrial and 19% of the ovarian cancer patients. The

  14. American Society of Clinical Oncology Policy Statement: The Role of the Oncologist in Cancer Prevention and Risk Assessment

    OpenAIRE

    Zon, Robin T.; Goss, Elizabeth; Vogel, Victor G.; Chlebowski, Rowan T.; Jatoi, Ismail; Robson, Mark E.; Wollins, Dana S.; Garber, Judy E.; Brown, Powel; Kramer, Barnett S.

    2008-01-01

    Oncologists have a critical opportunity to utilize risk assessment and cancer prevention strategies to interrupt the initiation or progression of cancer in cancer survivors and individuals at high risk of developing cancer. Expanding knowledge about the natural history and prognosis of cancers positions oncologists to advise patients regarding the risk of second malignancies and treatment-related cancers. In addition, as recognized experts in the full spectrum of cancer care, oncologists are ...

  15. Oral toxicity management in head and neck cancer patients treated with chemotherapy and radiation: Dental pathologies and osteoradionecrosis (Part 1) literature review and consensus statement.

    Science.gov (United States)

    Buglione, Michela; Cavagnini, Roberta; Di Rosario, Federico; Sottocornola, Lara; Maddalo, Marta; Vassalli, Lucia; Grisanti, Salvatore; Salgarello, Stefano; Orlandi, Ester; Paganelli, Corrado; Majorana, Alessandra; Gastaldi, Giorgio; Bossi, Paolo; Berruti, Alfredo; Pavanato, Giovanni; Nicolai, Piero; Maroldi, Roberto; Barasch, Andrei; Russi, Elvio G; Raber-Durlacher, Judith; Murphy, Barbara; Magrini, Stefano M

    2016-01-01

    Radiotherapy alone or in combination with chemotherapy and/or surgery is the typical treatment for head and neck cancer patients. Acute side effects (such as oral mucositis, dermatitis, salivary changes, taste alterations, etc.), and late toxicities in particular (such as osteo-radionecrosis, hypo-salivation and xerostomia, trismus, radiation caries etc.), are often debilitating. These effects tend to be underestimated and insufficiently addressed in the medical community. A multidisciplinary group of head and neck cancer specialists met in Milan with the aim of reaching a consensus on clinical definitions and management of these toxicities. The Delphi Appropriateness method was used for developing the consensus, and external experts evaluated the conclusions. This paper contains 10 clusters of statements about the clinical definitions and management of head and neck cancer treatment sequels (dental pathologies and osteo-radionecroses) that reached consensus, and offers a review of the literature about these topics. The review was split into two parts: the first part dealt with dental pathologies and osteo-radionecroses (10 clusters of statements), whereas this second part deals with trismus and xerostomia. PMID:26318095

  16. Cancer frequency in the Samtgemeinde Asse. Statement by the German Commission on Radiological Protection; Krebshaeufigkeit in der Samtgemeinde Asse. Stellungnahme der Strahlenschutzkommission mit wissenschaftlicher Begruendung

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-07-01

    41 reported diagnoses of cancer (EKN 2010b). The EKN established in (EKN 2010b) that after correction for multiple testing the results for all the municipalities of the district of Wolfenbuettel other than the Samtgemeinde Asse were not significant. The only significant findings were the results for leukaemia and thyroid cancer in the Samtgemeinde Asse. The Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU) wrote to the Commission on Radiological Protection (SSK) on 20 December 2010 requesting a statement on the results of the EKN's analysis of the incidence of cancer in the Samtgemeinde Asse. In particular, the statement needed to examine the statistical methods used and answer the following questions: Is there radiobiological information that could plausibly explain the findings? How can the findings be explained?.

  17. Biomarker triplet NAMPT/VEGF/HER2 as a de novo detection panel for the diagnosis and prognosis of human breast cancer.

    Science.gov (United States)

    Zhu, Yanyan; Guo, Meiyan; Zhang, Lingyun; Xu, Tao; Wang, Li; Xu, Guoxiong

    2016-01-01

    The early detection of breast cancer, the most common malignant tumor disease in women worldwide, relies on mammography and self breast examination. Here we evaluated the concentration of nicotinamide phosphoribosyltransferase (NAMPT), vascular endothelial growth factor (VEGF) and human epidermal growth factor receptor-2 (HER2) in serum and their expression in breast tissues associated with the clinicopathological features of patients with benign and malignant breast tumors. The immunohistochemical analysis showed that NAMPT, VEGF and HER2 proteins were overexpressed in breast tumors. The highest expression was observed in malignant tumors, low in benign tumors and negative in the adjacent normal tissue, indicating that the triplets may be progression markers and correlated with each other. The detection rate of NAMPT, VEGF and HER2 alone in tissue was 54.17, 64.58 and 60.42%, respectively, and was increased to about 79% in double combination and to 90% in triple combination. The basal levels of serum NAMPT, VEGF and HER2 in healthy controls were 94.90±4.24 pg/ml, 87.02±2.41 pg/ml and 1.12±0.04 ng/ml, respectively, measured by ELISA and found to be increased by 6.64-, 1.76- and 2.52-fold, respectively, in patients with malignant breast tumor. These elevated serum levels of NAMPT, VEGF and HER2 in patients were decreased after tumor removal, suggesting that these molecules are the indicators of treatment efficacy. The combined measurement of these triplets together may improve the sensitivity of breast cancer diagnosis and may potentially be used as a testing panel for the detection of malignant tumors, the assessment of treatment effectiveness and the monitoring of the disease progression in patients with breast cancer. Thus, we propose that the biomarker triplet NAMPT/VEGF/HER2 can be used as a de novo detection panel for the diagnosis and prognosis of human breast cancer. PMID:26531769

  18. 5-Fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency

    DEFF Research Database (Denmark)

    Bracht, K; Nicholls, A M; Liu, Ying;

    2010-01-01

    Colorectal cancer is (CRC) one of the commonest cancers and its therapy is still based on few drugs. Currently, no biological criteria are used to choose the most effective of the established drugs for treatment....

  19. Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer

    International Nuclear Information System (INIS)

    Although omic-based discovery approaches can provide powerful tools for biomarker identification, several reservations have been raised regarding the clinical applicability of gene expression studies, such as their prohibitive cost. However, the limited availability of antibodies is a key barrier to the development of a lower cost alternative, namely a discrete collection of immunohistochemistry (IHC)-based biomarkers. The aim of this study was to use a systematic approach to generate and screen affinity-purified, mono-specific antibodies targeting progression-related biomarkers, with a view towards developing a clinically applicable IHC-based prognostic biomarker panel for breast cancer. We examined both in-house and publicly available breast cancer DNA microarray datasets relating to invasion and metastasis, thus identifying a cohort of candidate progression-associated biomarkers. Of these, 18 antibodies were released for extended analysis. Validated antibodies were screened against a tissue microarray (TMA) constructed from a cohort of consecutive breast cancer cases (n = 512) to test the immunohistochemical surrogate signature. Antibody screening revealed 3 candidate prognostic markers: the cell cycle regulator, Anillin (ANLN); the mitogen-activated protein kinase, PDZ-Binding Kinase (PBK); and the estrogen response gene, PDZ-Domain Containing 1 (PDZK1). Increased expression of ANLN and PBK was associated with poor prognosis, whilst increased expression of PDZK1 was associated with good prognosis. A 3-marker signature comprised of high PBK, high ANLN and low PDZK1 expression was associated with decreased recurrence-free survival (p < 0.001) and breast cancer-specific survival (BCSS) (p < 0.001). This novel signature was associated with high tumour grade (p < 0.001), positive nodal status (p = 0.029), ER-negativity (p = 0.006), Her2-positivity (p = 0.036) and high Ki67 status (p < 0.001). However, multivariate Cox regression demonstrated that the signature was

  20. The correlation between the astro consensus panel definition of biochemical failure and clinical outcome for patients with prostate cancer treated with external beam irradiation

    International Nuclear Information System (INIS)

    Purpose: The ASTRO Consensus Panel on PSA After Radiation Therapy recently recommended a definition of biochemical failure (BF) following treatment of prostate cancer with radiation therapy. We reviewed our institution's experience treating patients with external beam irradiation (RT) to determine if the Consensus Panel definition correlates with clinical distant metastases free survival (DMFS), disease free survival (DFS), cause specific survival (CSS), and local control (LC) rates for a large group of patients from the PSA era. Methods And Materials: Between 1/1/87 and 12/31/92, 653 patients with clinically localized prostate cancer received external beam irradiation (RT) using localized prostate fields at William Beaumont Hospital. Of these patients, 568 had a minimum follow-up of 2 years and constitute the study population. The median pre-treatment PSA and Gleason score was 11 ng/ml and 6, respectively. The median dose to the prostate using megavoltage RT was 66.6 Gy (range: 60-70.4 Gy) using a four field or arc technique. No patient received hormonal therapy either prior to, during, or after radiotherapy unless local or distant failure was documented. Pre-treatment and post-treatment serum PSA levels were recorded. Biochemical failure was defined as three consecutive increases in post-treatment PSA after achieving a nadir. Biochemical failure was recorded as the time midway between the nadir and first increase in PSA. Five year actuarial rates of DMFS, DFS, CSS, and LC were calculated for patients who were biochemically controlled (BC) versus those who failed biochemically. Results: Median follow-up was 56 months (range: 24-118 months). The overall 5 year actuarial rates of DMFS, DFS, CSS, and LC were significantly better in patients who were biochemically controlled versus those who were not (p< 0.001). The median time to DM within the BF group was 21 months (range: 2-112 months). When stratifying by pre-treatment PSA, Gleason score, and T stage, these

  1. Application of flat panel OLED display technology for the point-of-care detection of circulating cancer biomarkers

    OpenAIRE

    Katchman, Benjamin A; Smith, Joseph T.; Uwadiae Obahiagbon; Sailaja Kesiraju; Yong-Kyun Lee; Barry O’Brien; Korhan Kaftanoglu; Jennifer Blain Christen; Anderson, Karen S.

    2016-01-01

    Point-of-care molecular diagnostics can provide efficient and cost-effective medical care, and they have the potential to fundamentally change our approach to global health. However, most existing approaches are not scalable to include multiple biomarkers. As a solution, we have combined commercial flat panel OLED display technology with protein microarray technology to enable high-density fluorescent, programmable, multiplexed biorecognition in a compact and disposable configuration with cli...

  2. Detection of Germline Mutation in Hereditary Breast and/or Ovarian Cancers by Next-Generation Sequencing on a Four-Gene Panel.

    Science.gov (United States)

    Kwong, Ava; Shin, Vivian Y; Au, Chun H; Law, Fian B F; Ho, Dona N; Ip, Bui K; Wong, Anthony T C; Lau, Silvia S; To, Rene M Y; Choy, Gigi; Ford, James M; Ma, Edmond S K; Chan, Tsun L

    2016-07-01

    Mutation in BRCA1/BRCA2 genes accounts for 20% of familial breast cancers, 5% to 10% of which may be due to other less penetrant genes which are still incompletely studied. Herein, a four-gene panel was used to examine the prevalence of BRCA1, BRCA2, TP53, and PTEN in hereditary breast and ovarian cancers in Southern Chinese population. In this cohort, 948 high-risk breast and/or ovarian patients were recruited for genetic screening by next-generation sequencing (NGS). The performance of our NGS pipeline was evaluated with 80 Sanger-validated known mutations and eight negative cases. With appropriate bioinformatics analysis pipeline, the detection sensitivity of NGS is comparable with Sanger sequencing. The prevalence of BRCA1/BRCA2 germline mutations was 9.4% in our Chinese cohort, of which 48.8% of the mutations arose from hotspot mutations. With the use of a tailor-made algorithm, HomopolymerQZ, more mutations were detected compared with single mutation detection algorithm. The frequencies of PTEN and TP53 were 0.21% and 0.53%, respectively, in the Southern Chinese patients with breast and/or ovarian cancers. High-throughput NGS approach allows the incorporation of control cohort that provides an ethnicity-specific data for polymorphic variants. Our data suggest that hotspot mutations screening such as SNaPshot could be an effective preliminary screening alternative adopted in a standard clinical laboratory without NGS setup. PMID:27157322

  3. Study of the performance of a novel 1 mm resolution dual-panel PET camera design dedicated to breast cancer imaging using Monte Carlo simulation

    International Nuclear Information System (INIS)

    We studied the performance of a dual-panel positron emission tomography (PET) camera dedicated to breast cancer imaging using Monte Carlo simulation. The PET camera under development has two 10x15 cm2 plates that are constructed from arrays of 1x1x3 mm3 LSO crystals coupled to novel ultra-thin (3 intrinsic spatial resolution, 3, 2x2x10 mm3, 3x3x30 mm3, and 4x4x20 mm3 LSO crystal resolutions and different panel separations. Images were reconstructed by focal plane tomography with attenuation and normalization corrections applied. Simulation results indicate that with an activity concentration ratio of tumor:breast:heart:torso of 10:1:10:1 and 30 s of acquisition time, only the dual-plate PET camera comprising 1x1x3 mm3 crystals could resolve 2.5 mm diameter spheres with an average peak-to-valley ratio of 1.3

  4. Setting up a wide panel of patient-derived tumor xenografts of non–small cell lung cancer by improving the preanalytical steps

    International Nuclear Information System (INIS)

    With the ongoing need to improve therapy for non–small cell lung cancer (NSCLC) there has been increasing interest in developing reliable preclinical models to test novel therapeutics. Patient-derived tumor xenografts (PDX) are considered to be interesting candidates. However, the establishment of such model systems requires highly specialized research facilities and introduces logistic challenges. We aimed to establish an extensive well-characterized panel of NSCLC xenograft models in the context of a long-distance research network after careful control of the preanalytical steps. One hundred fresh surgically resected NSCLC specimens were shipped in survival medium at room temperature from a hospital-integrated biobank to animal facilities. Within 24 h post-surgery, tumor fragments were subcutaneously xenografted into immunodeficient mice. PDX characterization was performed by histopathological, immunohistochemical, aCGH and next-generation sequencing approaches. For this model system, the tumor take rate was 35%, with higher rates for squamous carcinoma (60%) than for adenocarcinoma (13%). Patients for whom PDX tumors were obtained had a significantly shorter disease-free survival (DFS) compared to patients for whom no PDX tumors (P = 0.039) were obtained. We established a large panel of PDX NSCLC models with a high frequency of mutations (29%) in EGFR, KRAS, NRAS, MEK1, BRAF, PTEN, and PI3KCA genes and with gene amplification (20%) of c-MET and FGFR1. This new patient-derived NSCLC xenograft collection, established regardless of the considerable time required and the distance between the clinic and the animal facilities, recapitulated the histopathology and molecular diversity of NSCLC and provides stable and reliable preclinical models for human lung cancer research

  5. Rio 2016 financial statements

    OpenAIRE

    2015-01-01

    These documents include the report from independent auditors balance sheet, the statement of income, the statement of changes in equity, the statement of cash flows and the explanatory notes to the financial statements.

  6. EFSA Panel on Dietetic Products, Nutrition and Allergi es (NDA) ; Scientific Opinion - Statement on the safety of the “conjugated linoleic acid (CLA) - rich oils” Clarinol ® and Tonalin TG 80 as Novel Food ingredients

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to update its opinions on the safety of the conjugated linoleic acid (CLA)-rich oils Clarinol® and Tonalin® TG 80 as Novel Food ingredients in the light of additional information...

  7. Radiosensitivity profiles from a panel of ovarian cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent protein kinase activities

    Energy Technology Data Exchange (ETDEWEB)

    Langland, Gregory T.; Yannone, Steven M.; Langland, Rachel A.; Nakao, Aki; Guan, Yinghui; Long, Sydney B.T.; Vonguyen, Lien; Chen, David J.; Gray, Joe W; Chen, Fanqing

    2009-09-07

    The variability of radiation responses in ovarian tumors and tumor-derived cell lines is poorly understood. Since both DNA repair capacity and p53 status can significantly alter radiation sensitivity, we evaluated these factors along with radiation sensitivity in a panel of sporadic human ovarian carcinoma cell lines. We observed a gradation of radiation sensitivity among these sixteen lines, with a five-fold difference in the LD50 between the most radiosensitive and the most radioresistant cells. The DNA-dependent protein kinase (DNA-PK) is essential for the repair of radiation induced DNA double-strand breaks in human somatic cells. Therefore, we measured gene copy number, expression levels, protein abundance, genomic copy and kinase activity for DNA-PK in all of our cell lines. While there were detectable differences in DNA-PK between the cell lines, there was no clear correlation with any of these differences and radiation sensitivity. In contrast, p53 function as determined by two independent methods, correlated well with radiation sensitivity, indicating p53 mutant ovarian cancer cells are typically radioresistant relative to p53 wild-type lines. These data suggest that the activity of regulatory molecules such as p53 may be better indicators of radiation sensitivity than DNA repair enzymes such as DNAPK in ovarian cancer.

  8. Main findings, conclusions and recommendations of the Ignalina Safety Panel

    International Nuclear Information System (INIS)

    Ignalina Safety Panel was created to define, monitor and supervise the scope and production of the Ignalina Safety Analysis Report (SAR) and its Review (RSR); to review results of in-depth safety assessment addressing important contradictory statements; to give Lithuanian Government recommendations in view of further licensing process. In this paper General and Specific Recommendations provided by the Panel are presented

  9. Microsatellite instability analysis in hereditary non-polyposis colon cancer using the Bethesda consensus panel of microsatellite markers in the absence of proband normal tissue

    Directory of Open Access Journals (Sweden)

    Dourisboure Ricardo J

    2006-01-01

    Full Text Available Abstract Background Hereditary non-polyposis colon cancer (HNPCC is an autosomal dominant syndrome predisposing to the early development of various cancers including those of colon, rectum, endometrium, ovarium, small bowel, stomach and urinary tract. HNPCC is caused by germline mutations in the DNA mismatch repair genes, mostly hMSH2 or hMLH1. In this study, we report the analysis for genetic counseling of three first-degree relatives (the mother and two sisters of a male who died of colorectal adenocarcinoma at the age of 23. The family fulfilled strict Amsterdam-I criteria (AC-I with the presence of extracolonic tumors in the extended pedigree. We overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors. Methods Tumor MSI testing is described as initial screening in both primary and metastasis tumor tissue blocks, using the reference panel of 5 microsatellite markers standardized by the National Cancer Institute (NCI for the screening of HNPCC (BAT-25, BAT-26, D2S123, D5S346 and D17S250. Subsequent mutation analysis of the hMLH1 and hMSH2 genes was performed. Results Three of five microsatellite markers (BAT-25, BAT-26 and D5S346 presented different alleles in the proband's tumor as compared to those inherited from his parents. The tumor was classified as high frequency microsatellite instability (MSI-H. We identified in the HNPCC family a novel germline missense (c.1864C>A mutation in exon 12 of hMSH2 gene, leading to a proline 622 to threonine (p.Pro622Thr amino acid substitution. Conclusion This approach allowed us to establish the tumor MSI status using the NCI recommended panel in the absence of proband's non-tumor tissue and before sequencing the obligate carrier. According to the Human Gene Mutation Database (HGMD and the International Society for Gastrointestinal Hereditary Tumors (InSiGHT Database this is the first report of this mutation.

  10. 5 CFR 2429.27 - Service; statement of service.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Service; statement of service. 2429.27... LABOR RELATIONS AUTHORITY AND FEDERAL SERVICE IMPASSES PANEL FEDERAL LABOR RELATIONS AUTHORITY AND... Requirements § 2429.27 Service; statement of service. (a) Except as provided in § 2423.10(c) and (d), any...

  11. Screening for Prostate Cancer

    Science.gov (United States)

    ... of Internal Medicine Summaries for Patients Screening for Prostate Cancer: A Guidance Statement From the Clinical Guidelines Committee ... Physicians The full report is titled “Screening for Prostate Cancer: A Guidance Statement From the Clinical Guidelines Committee ...

  12. NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells.

    Directory of Open Access Journals (Sweden)

    Sevtap Savas

    Full Text Available Simvastatin and lovastatin are statins traditionally used for lowering serum cholesterol levels. However, there exists evidence indicating their potential chemotherapeutic characteristics in cancer. In this study, we used bioinformatic analysis of publicly available data in order to systematically identify the genes involved in resistance to cytotoxic effects of these two drugs in the NCI60 cell line panel. We used the pharmacological data available for all the NCI60 cell lines to classify simvastatin or lovastatin resistant and sensitive cell lines, respectively. Next, we performed whole-genome single marker case-control association tests for the lovastatin and simvastatin resistant and sensitive cells using their publicly available Affymetrix 125K SNP genomic data. The results were then evaluated using RNAi methodology. After correction of the p-values for multiple testing using False Discovery Rate, our results identified three genes (NRP1, COL13A1, MRPS31 and six genes (EAF2, ANK2, AKAP7, STEAP2, LPIN2, PARVB associated with resistance to simvastatin and lovastatin, respectively. Functional validation using RNAi confirmed that silencing of EAF2 expression modulated the response of HCT-116 colon cancer cells to both statins. In summary, we have successfully utilized the publicly available data on the NCI60 cell lines to perform whole-genome association studies for simvastatin and lovastatin. Our results indicated genes involved in the cellular response to these statins and siRNA studies confirmed the role of the EAF2 in response to these drugs in HCT-116 colon cancer cells.

  13. The correlation between the ASTRO consensus panel definition of biochemical failure and clinical outcome for patients with prostate cancer treated with external beam irradiation

    International Nuclear Information System (INIS)

    Purpose: We reviewed our institution's experience treating patients with external beam irradiation (RT) to determine if the ASTRO Consensus Panel definition of biochemical failure (BF) following radiation therapy correlates with clinical distant metastases free survival (DMFS), disease-free survival (DFS), cause-specific survival (CSS), and local control (LC). Methods and Materials: Between 1/1/87 and 12/31/92, 568 patients with clinically localized prostate cancer received external beam irradiation (RT) using localized prostate fields at William Beaumont Hospital (median total dose 66.6 Gy; range: 60-70.4 Gy). Biochemical failure was defined as three consecutive increases in post-treatment prostate specific antigen (PSA) after achieving a nadir. Biochemical failure was recorded as the time midway between the nadir and the first rising PSA. Five-year actuarial rates of clinical DMFS, DFS, CSS, and LC were calculated for patients who were biochemically controlled (BC) versus those who failed biochemically. Median follow-up was 56 months (range: 24-118 months). Results: Five-year actuarial rates of DMFS, DFS, CSS, and LC were significantly greater in patients who were biochemically controlled versus those who were not (p < 0.001). In patients who were BC, the 5-year actuarial rates of DMFS, DFS, CSS, and LC were 99%, 99%, 98%, and 99% respectively. For patients who failed biochemically, the 5-year actuarial rates of DMFS, DFS, CSS, and LC were 74%, 64%, 89%, and 86% respectively. When stratifying by pretreatment PSA, Gleason score, and T stage these differences remained significant for DMFS, DFS, and CSS. The Cox proportional hazards model demonstrated that BC was the single most important predictor of clinical outcome for DMFS, DFS, CSS, and LC. Pretreatment PSA and Gleason score were also independent predictors of outcome for DMFS and DFS. Conclusions: The ASTRO Consensus Panel definition of BF following radiation therapy correlates well with clinical DMFS, DFS

  14. Statement on the identity of apple snails

    DEFF Research Database (Denmark)

    Baker, R.; Candresse, T.; Dormannsné Simon, E.; Gilioli, G.; Grégoire, J.-C.; Jeger, M. J.; Karadjova, O. E.; Lövei, G.; Makowski, D.; Manceau, C.; Navajas, M.; Porta Puglia, A.; Rafoss, T.; Rossi, V.; Schans, J.; Schrader, G.; Urek, G.; van Lenteren, J. C.; Vloutoglou, I; Winter, S.; Zlotina, M.

    2012-01-01

    Following a request by the European Commission, EFSA’s Panel on Plant Health was asked to deliver a statement to clarify the current scientific knowledge regarding the identity of the apple snails in the context of the evaluation of the pest risk analysis prepared by the Spanish Ministry of Envir...

  15. Consensus Statement on Proton Therapy in Early-Stage and Locally Advanced Non-Small Cell Lung Cancer.

    Science.gov (United States)

    Chang, Joe Y; Jabbour, Salma K; De Ruysscher, Dirk; Schild, Steven E; Simone, Charles B; Rengan, Ramesh; Feigenberg, Steven; Khan, Atif J; Choi, Noah C; Bradley, Jeffrey D; Zhu, Xiaorong R; Lomax, Antony J; Hoppe, Bradford S

    2016-05-01

    Radiation dose escalation has been shown to improve local control and survival in patients with non-small cell lung cancer in some studies, but randomized data have not supported this premise, possibly owing to adverse effects. Because of the physical characteristics of the Bragg peak, proton therapy (PT) delivers minimal exit dose distal to the target volume, resulting in better sparing of normal tissues in comparison to photon-based radiation therapy. This is particularly important for lung cancer given the proximity of the lung, heart, esophagus, major airways, large blood vessels, and spinal cord. However, PT is associated with more uncertainty because of the finite range of the proton beam and motion for thoracic cancers. PT is more costly than traditional photon therapy but may reduce side effects and toxicity-related hospitalization, which has its own associated cost. The cost of PT is decreasing over time because of reduced prices for the building, machine, maintenance, and overhead, as well as newer, shorter treatment programs. PT is improving rapidly as more research is performed particularly with the implementation of 4-dimensional computed tomography-based motion management and intensity modulated PT. Given these controversies, there is much debate in the oncology community about which patients with lung cancer benefit significantly from PT. The Particle Therapy Co-operative Group (PTCOG) Thoracic Subcommittee task group intends to address the issues of PT indications, advantages and limitations, cost-effectiveness, technology improvement, clinical trials, and future research directions. This consensus report can be used to guide clinical practice and indications for PT, insurance approval, and clinical or translational research directions. PMID:27084663

  16. Evidence-based management of chemotherapy-induced nausea and vomiting: a position statement from a European cancer nursing forum

    OpenAIRE

    Vidall, C; Dielenseger, P; Farrell, C.; Lennan, E; Muxagata, P; Fernández-Ortega, P; Paradies, K

    2011-01-01

    Chemotherapy-induced nausea and vomiting (CINV) is a common, but now often overlooked side effect of cancer treatment, and one that can be largely prevented through the implementation of international evidence-based guidelines. The European CINV Forum, comprising nurses from France, Germany, Portugal, Spain and the UK, discussed the use of CINV preventive strategies in routine practice, and the factors that affect optimal delivery of antiemetic therapies. Based on these discussions, they deve...

  17. A Novel Biomarker Panel Examining Response to Gemcitabine with or without Erlotinib for Pancreatic Cancer Therapy in NCIC Clinical Trials Group PA.3.

    Directory of Open Access Journals (Sweden)

    David B Shultz

    Full Text Available NCIC Clinical Trials Group PA.3 was a randomized control trial that demonstrated improved overall survival (OS in patients receiving erlotinib in addition to gemcitabine for locally advanced or metastatic pancreatic cancer. Prior to therapy, patients had plasma samples drawn for future study. We sought to identify biomarkers within these samples.Using the proximity ligation assay (PLA, a probe panel was built from commercially available antibodies for 35 key proteins selected from a global genetic analysis of pancreatic cancers, and used to quantify protein levels in 20 uL of patient plasma. To determine if any of these proteins levels independently associated with OS, univariate and mulitbaraible Cox models were used. In addition, we examined the associations between biomarker expression and disease stage at diagnosis using Fisher's exact test. The correlation between Erlotinib sensitivity and each biomarkers was assessed using a test of interaction between treatment and biomarker.Of the 569 eligible patients, 480 had samples available for study. Samples were randomly allocated into training (251 and validation sets (229. Among all patients, elevated levels of interleukin-8 (IL-8, carcinoembryonic antigen (CEA, hypoxia-inducible factor 1-alpha (HIF-1 alpha, and interleukin-6 were independently associated with lower OS, while IL-8, CEA, platelet-derived growth factor receptor alpha and mucin-1 were associated with metastatic disease. Patients with elevated levels of receptor tyrosine-protein kinase erbB-2 (HER2 expression had improved OS when treated with erlotinib compared to placebo. In conclusion, PLA is a powerful tool for identifying biomarkers from archived, small volume serum samples. These data may be useful to stratify patient outcomes regardless of therapeutic intervention.ClinicalTrials.gov NCT00040183.

  18. Evidence-based management of chemotherapy-induced nausea and vomiting: a position statement from a European cancer nursing forum

    Science.gov (United States)

    Vidall, C; Dielenseger, P; Farrell, C; Lennan, E; Muxagata, P; Fernández-Ortega, P; Paradies, K

    2011-01-01

    Chemotherapy-induced nausea and vomiting (CINV) is a common, but now often overlooked side effect of cancer treatment, and one that can be largely prevented through the implementation of international evidence-based guidelines. The European CINV Forum, comprising nurses from France, Germany, Portugal, Spain and the UK, discussed the use of CINV preventive strategies in routine practice, and the factors that affect optimal delivery of antiemetic therapies. Based on these discussions, they developed a series of recommendations for optimal, evidence-based management of CINV. These state that all patients receiving chemotherapy should undergo full assessment of their risk of CINV and receive appropriate prophylactic treatment based on guidelines from the Multinational Association of Supportive Care in Cancer (MASCC) and the National Comprehensive Cancer Network (NCCN), which were both updated in 2011. Other recommendations, aimed at raising awareness of CINV and its management, include timely updates of relevant local practice guidelines and protocols, translation of the MASCC and NCCN guidelines into all European languages and their dissemination through accessible articles in nursing journals and newsletters and via nursing conferences and study days, improved training for nurses on CINV, collaboration between the European Oncology Nursing Society and national nursing organisations to promote consistent practice, the development of a CINV toolkit, information provision for patients, local audits of CINV management, and a survey of CINV management between and within European countries. PMID:22276054

  19. Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen.

    Science.gov (United States)

    Lynch, James T; McEwen, Robert; Crafter, Claire; McDermott, Ultan; Garnett, Mathew J; Barry, Simon T; Davies, Barry R

    2016-04-19

    Selective phosphoinositide 3-kinase (PI3K)/AKT/mTOR inhibitors are currently under evaluation in clinical studies. To identify tumor types that are sensitive to PI3K pathway inhibitors we screened compounds targeting PI3Kα/δ (AZD8835), PI3Kβ/δ (AZD8186), AKT (AZD5363) and mTORC1/2 (AZD2014) against a cancer cell line panel (971 cell lines). There was an enrichment of hematological malignancies that were sensitive to AKT and mTOR inhibition, with the greatest degree of sensitivity observed in T-cell acute lymphoblastic leukemia (T-ALL). We found that all NOTCH mutant T-ALL cell lines were sensitive to AKT and mTORC1/2 inhibitors, with only partial sensitivity to agents that target the PI3K α, β or δ isoforms. Induction of apoptosis only occurred following AKTi treatment in cell lines with PTEN protein loss and high levels of active AKT. In summary, we have demonstrated that T-ALL cell lines show differential sensitivity to inhibition at different nodes in the PI3K/AKT/mTOR pathway and inhibiting AKT or mTOR may have a therapeutic benefit in this disease setting. PMID:26989080

  20. Panel discussion

    Energy Technology Data Exchange (ETDEWEB)

    No Author Given

    1975-01-01

    Panel discussion: summation and future projections. Introductory remarks by panelists followed by questions and comments from the floor. Panelists: Dr. Joseph Barnea (former director of Resources and Transport for the United Nations; energy consultant to the United Nations Institute for Training and Research (UNITAR)); the Honorable Clyde F. Bel, Jr. (member of the Louisiana House of Representatives representing District 90 and New Orleans); Dr. David Lombard (acting chief of the Advanced Systems Branch of the Division of Geothermal Energy Research and Technology, Energy Research and Development Administration (ERDA)); Fred C. Repper (vice-president of Central Power and Light Company in Corpus Christi, Texas); Dr. Hans Suter (environmental consultant in Corpus Christi, Texas; environmental columnist for the Corpus Christi Caller Times). Session chairman: Herbert Woodson.

  1. Heat exchanger panel

    Science.gov (United States)

    Warburton, Robert E. (Inventor); Cuva, William J. (Inventor)

    2005-01-01

    The present invention relates to a heat exchanger panel which has broad utility in high temperature environments. The heat exchanger panel has a first panel, a second panel, and at least one fluid containment device positioned intermediate the first and second panels. At least one of the first panel and the second panel have at least one feature on an interior surface to accommodate the at least one fluid containment device. In a preferred embodiment, each of the first and second panels is formed from a high conductivity, high temperature composite material. Also, in a preferred embodiment, the first and second panels are joined together by one or more composite fasteners.

  2. EFSA BIOHAZ Panel (EFSA Panel on Biological Hazards), 2014. Statement on the update of the list of QPS-recommended biological agents intentionally added to food or feed as notified to EFSA 1: Suitability of taxonomic units notified to EFSA until October 2014

    OpenAIRE

    Hald, Tine; Baggesen, Dorte Lau

    2014-01-01

    EFSA is requested to assess the safety of a broad range of biological agents in the context of notifications for market authorisation as sources of food and feed additives, enzymes and plant protection products. The qualified presumption of safety (QPS) assessment was developed to provide a harmonised generic pre-assessment to support safety risk assessments performed by EFSA’s scientific Panels. The safety of unambiguously defined biological agents (at the highest taxonomic unit appropriate ...

  3. Guidelines for Follow-Up of Women at High Risk for Inherited Breast Cancer: Consensus Statement from the Biomed 2 Demonstration Programme on Inherited Breast Cancer

    Directory of Open Access Journals (Sweden)

    P. Møller

    1999-01-01

    Full Text Available Protocols for activity aiming at early diagnosis and treatment of inherited breast or breast-ovarian cancer have been reported. Available reports on outcome of such programmes are considered here. It is concluded that the ongoing activities should continue with minor modifications. Direct evidence of a survival benefit from breast and ovarian screening is not yet available. On the basis of expert opinion and preliminary results from intervention programmes indicating good detection rates for early breast cancers and 5-year survival concordant with early diagnosis, we propose that women at high risk for inherited breast cancer be offered genetic counselling, education in ‘breast awareness’ and annual mammography and clinical expert examination from around 30 years of age. Mammography every second year may be sufficient from 60 years on. BRCA1 mutation carriers may benefit from more frequent examinations and cancer risk may be reduced by oophorectomy before 40–50 years of age. We strongly advocate that all activities should be organized as multicentre studies subjected to continuous evaluation to measure the effects of the interventions on long-term mortality, to match management options more precisely to individual risks and to prepare the ground for studies on chemoprevention.

  4. ACR Appropriateness Criteria on Induction and Adjuvant Therapy for Stage N2 Non-Small-Cell Lung Cancer: Expert Panel on Radiation Oncology-Lung

    International Nuclear Information System (INIS)

    'The American College of Radiology seeks and encourages collaboration with other organizations on the development of the ACR Appropriateness Criteria through society representation on expert panels. Participation by representatives from collaborating societies on the expert panel does not necessarily imply society endorsement of the final document.'

  5. American Society of Clinical Oncology policy statement update: tobacco control--reducing cancer incidence and saving lives. 2003.

    Science.gov (United States)

    2003-07-15

    As an international medical society dedicated to cancer prevention, the American Society of Clinical Oncology (ASCO) advocates a fundamental reform of United States and international policy toward addictive tobacco products. ASCO's goal is the immediate reduction of tobacco use and ultimate achievement of a tobacco-free world. The centerpiece of ASCO's policy is the recommendation for an independent commission to study the tobacco problem in all of its dimensions: social, medical, legal, and economic (both domestically and globally). The commission membership should include broad-based representation and expertise on tobacco issues. In ASCO's view, tobacco control efforts to date have been less than successful because they are too fragmented and incremental, leaving many important issues unaddressed. A more comprehensive solution could flow from this study, including input from a variety of government agencies involved with public health, agriculture, First Amendment and other legal considerations, and international trade. The study, within defined time limits, should culminate in a report that outlines a strategy for achieving immediate reduction of tobacco use and ultimate achievement of a tobacco-free world, including explicit plans and a timetable for implementation. Although this comprehensive approach to tobacco control will take many years to implement even under the best of circumstances, there are certain measures that could be undertaken immediately with meaningful impact on tobacco usage. These include: Increasing efforts to discourage tobacco use, particularly among the young Raising federal excise taxes by at least $2 per pack and encouraging states to consider tobacco taxes as a first resort in revenue enhancement Ensuring that tobacco settlement funds be devoted only to health-related projects, including medical treatment, biomedical research, and tobacco prevention efforts Requiring disclosure of all ingredients in tobacco products Comprehensively

  6. EFSA BIOHAZ Panel (EFSA Panel on Biological Hazards), 2014. Statement on the update of the list of QPS-recommended biological agents intentionally added to food or feed as notified to EFSA 1: Suitability of taxonomic units notified to EFSA until October 2014

    DEFF Research Database (Denmark)

    Hald, Tine; Baggesen, Dorte Lau

    harmonised generic pre-assessment to support safety risk assessments performed by EFSA’s scientific Panels. The safety of unambiguously defined biological agents (at the highest taxonomic unit appropriate for the purpose for which an application is intended), and the completeness of the body of knowledge are...... assessed. Identified safety concerns for a taxonomic unit are, where possible and reasonable in number, reflected as ‘qualifications’ in connection with a recommendation for a QPS status. A total of 99 biological agents were notified to EFSA between May 2013 and October 2014. From those, 26 biological...... agents already had a QPS status and were not further evaluated, and 54 were also not included as they are filamentous fungi or enterococci, biological groups which have been excluded from the QPS activities since 2014. The remaining 19 notifications were considered for the assessment of the suitability...

  7. Rio 2016 financial statements 2011

    OpenAIRE

    2015-01-01

    This document includes the report from independent auditors, the balance sheet, the statement of income, the statement of changes in equity, the statement of cash flows and the explanatory notes to the financial statements as of December 2011.

  8. Hepatitis virus panel

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/003558.htm Hepatitis virus panel To use the sharing features on this page, please enable JavaScript. The hepatitis virus panel is a series of blood tests used ...

  9. Financial Statements Analysis

    OpenAIRE

    Tănase Alin-Eliodor

    2014-01-01

    This article focuses on analyzing of a consolidated financial statements of a hypothetically SME. The interpretation of the financial position and performances is based on the more than 40 financial key ratios computed by using financial data from consolidated income statement, consolidated financial position and cash flow. However additional data from notes to financial statements are provided.

  10. Financial Statement Math

    OpenAIRE

    2007-01-01

    The purpose of this interactive exercise is to help you understand the math in the income statement and balance sheet., Give the proper mathematical computations in order to correctly prepare the income statement and the balance sheet.The exercise is divided into 3 parts: The income Statement, The Balance Sheet - Assets, The Balance Sheet - Liabilities,

  11. Financial Statements Analysis

    Directory of Open Access Journals (Sweden)

    Tănase Alin-Eliodor

    2014-10-01

    Full Text Available This article focuses on analyzing of a consolidated financial statements of a hypothetically SME. The interpretation of the financial position and performances is based on the more than 40 financial key ratios computed by using financial data from consolidated income statement, consolidated financial position and cash flow. However additional data from notes to financial statements are provided.

  12. 12 CFR 269b.740 - Service of pleading and other paper; statement of service.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Service of pleading and other paper; statement... of pleading and other paper; statement of service. (a) Method of service. Notices of hearings... serving the papers or process shall submit simultaneously to the panel or its designated...

  13. Financial Statement Preparing.

    OpenAIRE

    Benešová, Barbora

    2011-01-01

    Financial statement can be regarded as a key document made on the balancing day (the date of closing of books) in case of annual financial statement, or on another day than balancing day, in which case it is called a special-purpose or interim financial statement. Financial statement is defined by Act No. 563/1991 Coll., on accounting, as an indivisible whole, consisting of a balance sheet, a profit and loss statement and a supplement. Selected accounting entities under § 20 par. 1 further...

  14. The Evolving Role of Nivolumab in Non-Small-Cell Lung Cancer for Second-Line Treatment: A New Cornerstone for Our Treatment Algorithms. Results From an International Experts Panel Meeting of the Italian Association of Thoracic Oncology.

    Science.gov (United States)

    Gridelli, Cesare; Besse, Benjamin; Brahmer, Julie Renee; Crinò, Lucio; Felip, Enriqueta; de Marinis, Filippo

    2016-05-01

    Lung cancer is the leading cause of death from cancer worldwide that currently has only a few available treatment options in patients with no driver mutations. The therapeutic options for patients with non-small-cell lung cancer (NSCLC) who progress after first-line chemotherapy have been limited from a long time. Docetaxel has remained a cornerstone of second-line treatment for more than 20 years, but it is associated with an unfavorable safety profile. Recently, the results from immunotherapy treatment with anti-PD1 and PD-L1 inhibitors has changed our current knowledge base and increased therapeutic options for patients with NSCLC in the second-line setting. The results of 2 randomized phase III trials assessing nivolumab in lung cancer, Check-Mate-017 and Check-Mate-057, have deeply changed our current clinical practice and raised several discussion points. This paper explores the recent findings about nivolumab for the treatment of NSCLC in the second-line setting by analyzing recent trial findings and discussing their implications in clinical practice and future directions. The paper also summarizes the conclusions from an International Experts Panel Meeting of the Italian Association of Thoracic Oncology. PMID:26908078

  15. ICFA neutrino panel report

    Science.gov (United States)

    Long, K.

    2015-07-01

    In the summer of 2013 the International Committee on Future Accelerators (ICFA) established a Neutrino Panel with the mandate: "To promote international cooperation in the development of the accelerator-based neutrino-oscillation program and to promote international collaboration in the development of a neutrino factory as a future intense source of neutrinos for particle physics experiments." In its first year the Panel organised a series of regional Town Meetings to collect input from the community and to receive reports from the regional planning exercises. The Panel distilled its findings and presented them in a report to ICFA [1]. In this contribution the formation and composition of the Panel are presented together with a summary of the Panel's findings from the three Regional Town Meetings. The Panel's initial conclusions are then articulated and the steps that the Panel seeks to take are outlined.

  16. 16 CFR 500.4 - Statement of identity.

    Science.gov (United States)

    2010-01-01

    ... INTERPRETATION AND EXEMPTIONS UNDER THE FAIR PACKAGING AND LABELING ACT REGULATIONS UNDER SECTION 4 OF THE FAIR PACKAGING AND LABELING ACT § 500.4 Statement of identity. (a) The principal display panel of a consumer... in the commodity in a substantial or significantly effective amount may not be mentioned in...

  17. Paneling architectural freeform surfaces

    KAUST Repository

    Eigensatz, Michael

    2010-07-26

    The emergence of large-scale freeform shapes in architecture poses big challenges to the fabrication of such structures. A key problem is the approximation of the design surface by a union of patches, socalled panels, that can be manufactured with a selected technology at reasonable cost, while meeting the design intent and achieving the desired aesthetic quality of panel layout and surface smoothness. The production of curved panels is mostly based on molds. Since the cost of mold fabrication often dominates the panel cost, there is strong incentive to use the same mold for multiple panels. We cast the major practical requirements for architectural surface paneling, including mold reuse, into a global optimization framework that interleaves discrete and continuous optimization steps to minimize production cost while meeting user-specified quality constraints. The search space for optimization is mainly generated through controlled deviation from the design surface and tolerances on positional and normal continuity between neighboring panels. A novel 6-dimensional metric space allows us to quickly compute approximate inter-panel distances, which dramatically improves the performance of the optimization and enables the handling of complex arrangements with thousands of panels. The practical relevance of our system is demonstrated by paneling solutions for real, cutting-edge architectural freeform design projects. © 2010 ACM.

  18. Paneling architectural freeform surfaces

    KAUST Repository

    Eigensatz, Michael

    2010-07-25

    The emergence of large-scale freeform shapes in architecture poses big challenges to the fabrication of such structures. A key problem is the approximation of the design surface by a union of patches, so-called panels, that can be manufactured with a selected technology at reasonable cost, while meeting the design intent and achieving the desired aesthetic quality of panel layout and surface smoothness. The production of curved panels is mostly based on molds. Since the cost of mold fabrication often dominates the panel cost, there is strong incentive to use the same mold for multiple panels. We cast the major practical requirements for architectural surface paneling, including mold reuse, into a global optimization framework that interleaves discrete and continuous optimization steps to minimize production cost while meeting user-specified quality constraints. The search space for optimization is mainly generated through controlled deviation from the design surface and tolerances on positional and normal continuity between neighboring panels. A novel 6-dimensional metric space allows us to quickly compute approximate inter-panel distances, which dramatically improves the performance of the optimization and enables the handling of complex arrangements with thousands of panels. The practical relevance of our system is demonstrated by paneling solutions for real, cutting-edge architectural freeform design projects.

  19. Report of the Federal Panel on Formaldehyde.

    OpenAIRE

    1982-01-01

    The Federal Panel on Formaldehyde concluded that definitive experiments exist which demonstrate the mutagenicity and carcinogenicity of formaldehyde under laboratory conditions. Formaldehyde induces both gene mutations and chromosomal aberrations in a variety of test systems. Inhalation of formaldehyde causes cancer of the nose in rats. The concentrations of formaldehyde in inhaled air that caused nasal cancer in Fisher 344 rats are within the same order of magnitude as those to which humans ...

  20. Titanium honeycomb panel testing

    Science.gov (United States)

    Richards, W. L.; Thompson, Randolph C.

    The paper describes the procedures of thermal mechanical tests carried out at the NASA Dryden Flight Research Facility on two tianium honeycomb wing panels bonded using liquid interface diffusion (LID) technique, and presents the results of these tests. The 58.4 cm square panels consisted of two 0.152-cm-thick Ti 6-2-4-2 face sheets LID-bonded to a 1.9-cm-thick honeycomb core, with bearing plates fastened to the perimeter of the upper and the lower panel surfaces. The panels were instrumented with sensors for measuring surface temperature, strain, and deflections to 315 C and 482 C. Thermal stress levels representative of those encountered during aerodynamic heating were produced by heating the upper panel surface and restraining all four edges. After more than 100 thermal cycles from room temperature to 315 C and 50 cycles from room temperature to 482 C, no significant structural degradation was detected in the panels.

  1. REINFORCED COMPOSITE PANEL

    DEFF Research Database (Denmark)

    2003-01-01

    A composite panel having front and back faces, the panel comprising facing reinforcement, backing reinforcement and matrix material binding to the facing and backing reinforcements, the facing and backing reinforcements each independently comprising one or more reinforcing sheets, the facing...... matrix material, the facing and backing reinforcements being interconnected to resist out-of-plane relative movement. The reinforced composite panel is useful as a barrier element for shielding structures, equipment and personnel from blast and/or ballistic impact damage....

  2. NCI and the Chinese Academy of Medical Sciences Sign Statement of Intent

    Science.gov (United States)

    Today the National Cancer Institute (NCI) and the Cancer Institute/Hospital of the Chinese Academy of Medical Sciences (CICAMS) signed a statement of intent to share an interest in fostering collaborative biomedical research in oncology and a common goal

  3. Make Your Own Solar Panel.

    Science.gov (United States)

    Suzuki, David

    1992-01-01

    Presents an activity in which students make a simulated solar panel to learn about the principles behind energy production using solar panels. Provides information about how solar panels function to produce energy. (MCO)

  4. Opening statements and general statements by delegation

    International Nuclear Information System (INIS)

    23 delegations have submitted general reports and statements on the situation and evolution of the nuclear fuel cycle. Each report reflects the particular interests of the country that submitted it. All in all, these reports provide general background information on the subject of the conference

  5. Prevention and management of chemotherapy-induced diarrhea in patients with colorectal cancer: a consensus statement by the Canadian Working Group on Chemotherapy-Induced Diarrhea

    OpenAIRE

    Maroun, J A; Anthony, L.B.; Blais, N; Burkes, R.; Dowden, S.D.; Dranitsaris, G; Samson, B.; Shah, A.; Thirlwell, M.P.; Vincent, M D; Wong, R.

    2007-01-01

    Chemotherapy-induced diarrhea (cid) is a common side effect of cancer treatment and can cause significant morbidity and mortality. Diarrhea is frequently severe enough to require a dose reduction of, a delay in, or a discontinuation of chemotherapy. Diarrhea-associated mortality has been reported to be as high as 3.5% in clinical trials of irinotecan and bolus 5-fluorouracil in colorectal cancer. The frequency of cid and its impact on patient management are frequently under-recognized in clin...

  6. Breast cancer screening in the era of density notification legislation: summary of 2014 Massachusetts experience and suggestion of an evidence-based management algorithm by multi-disciplinary expert panel.

    Science.gov (United States)

    Freer, Phoebe E; Slanetz, Priscilla J; Haas, Jennifer S; Tung, Nadine M; Hughes, Kevin S; Armstrong, Katrina; Semine, A Alan; Troyan, Susan L; Birdwell, Robyn L

    2015-09-01

    Stemming from breast density notification legislation in Massachusetts effective 2015, we sought to develop a collaborative evidence-based approach to density notification that could be used by practitioners across the state. Our goal was to develop an evidence-based consensus management algorithm to help patients and health care providers follow best practices to implement a coordinated, evidence-based, cost-effective, sustainable practice and to standardize care in recommendations for supplemental screening. We formed the Massachusetts Breast Risk Education and Assessment Task Force (MA-BREAST) a multi-institutional, multi-disciplinary panel of expert radiologists, surgeons, primary care physicians, and oncologists to develop a collaborative approach to density notification legislation. Using evidence-based data from the Institute for Clinical and Economic Review, the Cochrane review, National Comprehensive Cancer Network guidelines, American Cancer Society recommendations, and American College of Radiology appropriateness criteria, the group collaboratively developed an evidence-based best-practices algorithm. The expert consensus algorithm uses breast density as one element in the risk stratification to determine the need for supplemental screening. Women with dense breasts and otherwise low risk (20% lifetime) should consider supplemental screening MRI in addition to routine mammography regardless of breast density. We report the development of the multi-disciplinary collaborative approach to density notification. We propose a risk stratification algorithm to assess personal level of risk to determine the need for supplemental screening for an individual woman. PMID:26290416

  7. NCI and the Republic of Peru Sign Statement of Intent

    Science.gov (United States)

    The U.S. National Cancer Institute and the Republic of Peru signed a statement of intent to share an interest in fostering collaborative biomedical research in oncology and a common goal in educating and training the next generation of cancer research sci

  8. Using motivational statements in web instrument design to reduce item missing rates in a mixed-mode context

    OpenAIRE

    Al Baghal, Tarek; Lynn, Peter

    2014-01-01

    Web surveys generally produce higher item nonresponse than face-to-face administration.This study examines alternative forms of motivational statements to reduce item nonresponsein a web survey, using an experiment in the UKHLS Innovation Panel. Findings show that amotivational statement following immediately after an unanswered item outperforms eitherthe control, presenting only opt-out options after an initial skip attempt, or a later-placedmotivational statement. The immediate prompt reduc...

  9. Hepatitis virus panel

    Science.gov (United States)

    The hepatitis virus panel is a series of blood tests used to detect current or past infection by hepatitis A , hepatitis ... samples for more than one kind of hepatitis virus at the same time. Antibody and antigen tests ...

  10. Autoimmune liver disease panel

    Science.gov (United States)

    Liver disease test panel - autoimmune ... Autoimmune disorders are a possible cause of liver disease. The most common of these diseases are autoimmune hepatitis and primary biliary cirrhosis. This group of tests helps your health care provider ...

  11. Honeycomb metal panel

    International Nuclear Information System (INIS)

    Product constituted by a honeycomb metal panel that can be employed to advantage for manufacturing lagging by sandwiching it between two plane sheets, utilized in particular in the nuclear industry where lagging has to have a very long life strength. The honeycomb metal panel is made of an expanded metal extrusion previously cut so as to form, after additional drawing, a honeycomb structure with square or rectangular cells with a plane surface

  12. Equal Opportunities Advisory Panel

    CERN Multimedia

    HR Department

    2006-01-01

    At its meeting on 7 December 2006, the Standing Concertation Committee took note of the appointment of four new members of the Panel: Wisla Carena, Pierre Charrue, Sue Foffano and Markus Nordberg. The present composition of the Panel (appointed ad personam) is as follows: Tiziano Camporesi (Chairperson), Wisla Carena, Pierre Charrue, Sue Foffano, Josi Schinzel (Equal Opportunities Officer), Markus Nordberg, Christine Petit-Jean-Genaz et Elena Wildner. Human Resources Department Tel. 74480

  13. Farm and Ranch Financial Statements

    OpenAIRE

    Israelsen, Clark; Feuz, Dillon

    2014-01-01

    This fact sheet is a brief overview of the financial statements and budgeting tools that are likely a part of most farm financial record keeping systems. Links are provided for additional detail on any one financial report or topic. A brief description of a Balance Sheet, a Profit Loss Statement or Income Statement, Statement of Cash Flows and Enterprise Analysis is included.

  14. Audit of Financial Statement

    OpenAIRE

    Černá, Helena

    2011-01-01

    The goal of the work is the audit of financial statement of the selected subject and suggestions to improve process of audit and accounting to display the reality fair and accurately. The process of audit is simplified for small firms. Theoretic part is dedicated to laws and regulations, which are obligatory for audit, and technical literature for audit. In the second practical part, audit procedures for real company financial statement verification are implemented. This part is divide...

  15. Validation of an algorithm able to differentiate small-cell lung cancer (SCLC) from non-small-cell lung cancer (NSCLC) patients by means of a tumour marker panel: analysis of the errors.

    OpenAIRE

    Paone, G; De Angelis, G.; Portalone, L.; Greco, S.; Giosué, S.; Taglienti, A.; Bisetti, A; Ameglio, F.

    1997-01-01

    By means of a mathematical score previously generated by discriminant analysis on 90 lung cancer patients, a new and larger group of 261 subjects [209 with non-small-cell lung cancer (NSCLC) and 52 with small-cell lung cancer (SCLC)] was analysed to confirm the ability of the method to distinguish between these two types of cancers. The score, which included the serum neuron-specific enolase (NSE) and CYFRA-21.1 levels, permitted correct classification of 93% of the patients. When the misclas...

  16. Radiation Therapy Oncology Group Consensus Panel Guidelines for the Delineation of the Clinical Target Volume in the Postoperative Treatment of Pancreatic Head Cancer

    International Nuclear Information System (INIS)

    Purpose: To develop contouring guidelines to be used in the Radiation Therapy Oncology Group protocol 0848, a Phase III randomized trial evaluating the benefit of adjuvant chemoradiation in patients with resected head of pancreas cancer. Methods and Materials: A consensus committee of six radiation oncologists with expertise in gastrointestinal radiotherapy developed stepwise contouring guidelines and an atlas for the delineation of the clinical target volume (CTV) in the postoperative treatment of pancreas cancer, based on identifiable regions of interest and margin expansions. Areas at risk for subclinical disease to be included in the CTV were defined, including nodal regions, anastomoses, and the preoperative primary tumor location. Regions of interest that could be reproducibly contoured on postoperative imaging after a pancreaticoduodenectomy were identified. Standardized expansion margins to encompass areas at risk were developed after multiple iterations to determine the optimal margin expansions. Results: New contouring recommendations based on CT anatomy were established. Written guidelines for the delineation of the postoperative CTV and normal tissues, as well as a Web-based atlas, were developed. Conclusions: The postoperative abdomen has been a difficult area for effective radiotherapy. These new guidelines will help physicians create fields that better encompass areas at risk and minimize dose to normal tissues.

  17. Correlation of Various Biomarkers with Axillary Nodal Metastases: Can a Panel of Such Biomarkers Guide Selective Use of Axillary Surgery in T1 Breast Cancer?

    Science.gov (United States)

    Dass, Tufale A; Rakesh, Sharma; Prakash, K Patil; Singh, Chandraveer

    2015-12-01

    To evaluate the correlation of various clinic-pathological variables with axillary nodal involvement in T1 breast cancer & to identify a sub-group of T1 cancers, on the basis of observed variables, with a low risk of axillary nodal metastases. Clinico-pathological variables observed included tumor size, lymphovascular invasion (LVI), histological grade of tumor, tumor palpability, estrogen/progesterone (ER/PR) & her2/neu receptors, age, family history, histological type of tumor, axillary nodal metastases for 100 patients without clinically palpable nodes who underwent axillary lymph node dissection in Bombay Hospital & Medical Research Center from March, 2009. Data compiled was analyzed by univariate & multivariate analysis. All the variables viz. tumor size, LVI, histological grade, tumor palpability & ER/PR/Her2 receptor profile, which were found to be significantly associated with axillary lymph node involvement (ALNI) on univariate analysis were also found to be independent predictors of ALNI on multivariate analysis. Age of the patient, family history & histological type of tumor were not significantly correlated with ALNI. None of the 12 patients with tumor biomarker profile of T1a-b tumors without LVI & with histological grade I, had ALNI. The risk of ALNI can be predicted by using various tumor biomarker variables. Based on the predicted risk of ALNI, the management strategy for axilla can be individualized. The omission of operative axillary staging may be considered in patients with low predictive risk of ALNI. PMID:27065659

  18. [Summary of the Israeli Endocrine Society's consensus statement on the diagnosis, treatment and follow-up of well-differentiated thyroid cancer].

    Science.gov (United States)

    Arbelle, Jonathan E; Shalom, Sophia Ish; Benbassat, Carlos; Dickstein, Gabriel; Glasser, Benjamin; Liel, Yair

    2008-10-01

    Well differentiated epithelial cell thyroid cancer is not classified amongst the most aggressive diseases. Notwithstanding, it can potentially both impair quality of life and affect life expectancy. Appropriate treatment has been shown to be crucial in obtaining optimal outcomes on the course of the disease. Successful treatment rests upon strict adherence to confirmed principles of diagnosis, treatment and follow-up. The aim of the position paper is to present the Israeli medical community with a set of commonly accepted principles for the diagnosis, treatment and follow-up of patients with well differentiated epithelial thyroid cancer and in addition to highlight areas of legitimate differences in approach where those differences occur. We have attempted to provide a link between the various medical disciplines involved in care of these patients: family physicians, surgeons, nuclear medicine specialists, oncologists, pathologists, radiologists and endocrinologists; and have attempted to decrease to a minimum areas of uncertainty and to offer a common approach for the best possible care of thyroid cancer patients in Israel. In addition, we find it our duty to point out those areas and resources which, in our opinion, need to be upgraded in Israel and even included in the Israeli official "health basket". PMID:19039917

  19. Panel 3 - characterization

    Energy Technology Data Exchange (ETDEWEB)

    Erck, R.A.; Erdemir, A.; Janghsing Hsieh; Lee, R.H.; Xian Zheng Pan; Deming Shu [Argonne National Lab., IL (United States); Feldman, A. [National Inst. of Standards and Technology, Gaithersburg, MD (United States); Glass, J.T. [North Carolina State Univ., Raleigh (United States); Kleimer, R. [Coors Ceramics Co., Golden, CO (United States); Lawton, E.A. [JPL/Caltech, Pasadena, CA (United States); McHargue, C.J. [Univ. of Tennessee, Knoxville (United States)

    1993-01-01

    The task of this panel was to identify and prioritize needs in the area of characterization of diamond and diamond-like-carbon (DLC) films for use in the transportation industry. Until recent advances in production of inexpensive films of diamonds and DLC, it was not feasible that these materials could be mass produced. The Characterization Panel is restricting itself to identifying needs in areas that would be most useful to manufacturers and users in producing and utilizing diamond and DLC coatings in industry. These characterization needs include in-situ monitoring during growth, relation of structure to performance, and standards and definitions.

  20. Statement of changes in equity.

    OpenAIRE

    Gallardo Ramiro, M V; Hernández Gañán, S

    2010-01-01

    Since the new General Chart of Accounts was passed, the amount of financial information that is required to the corporations had increased. There have been two new financial statements too: Statement of Changes in Equity and Cash Flow Statement. We analyze the Statement of Changes in Equity on this paper, and the changes result of the new financial statement. Also, the statement of changes in equity has two new accounts: 8th group “Expenditure of Equity” and 9th group “Income of Equity”. The ...

  1. Auditing nuclear materials statements

    International Nuclear Information System (INIS)

    A standard that may be used as a guide for persons making independent examinations of nuclear materials statements or reports regarding inventory quantities on hand, receipts, production, shipment, losses, etc. is presented. The objective of the examination of nuclear materials statements by the independent auditor is the expression of an opinion on the fairness with which the statements present the nuclear materials position of a nuclear materials facility and the movement of such inventory materials for the period under review. The opinion is based upon an examination made in accordance with auditing criteria, including an evaluation of internal control, a test of recorded transactions, and a review of measured discards and materials unaccounted for (MUF). The standard draws heavily upon financial auditing standards and procedures published by the American Institute of Certified Public Accountants

  2. THE STATEMENT OF CASH FLOWS USING FINANCIAL STATEMENT EQUATIONS

    OpenAIRE

    Harold Fletcher; Thomas Ulrich

    2010-01-01

    This paper addresses one of the more difficult topics in teaching MBA level financial management, the statement of cash flows. By employing financial statement equations in preparing the statement of cash flows, students: (1) are employing tools that they are more familiar and comfortable with which mitigates their anxiety and enhances their understanding, (2) are better able to understand the logic of the statement of cash flows and the relationships that exist between it and the income stat...

  3. Student Panels, Business Administration

    DEFF Research Database (Denmark)

    Rask, Morten

    the Head of MSc programmes, the MSc coordinator as well as the administrative secretary. A student panel meets with the department twice in the first year: Early in February to sum up experience from the first semester and in early in June to sum up experience from the second semester. At semester...

  4. Financial Statements in Particular Entity

    OpenAIRE

    Hořáková, Marie

    2011-01-01

    The thesis delivers suggestions to improve procedures in a financial statement from particular company according to an analysis of individual financial statement pieces and tests of a financial statement report. The first part of the literature search is devoted to an analysis of preparing pieces of the Financial Statement, necessary to carry out at the end of any accounting year to avoid distorting in accounting. After counting all issues, the accounting entity is to close all accounting...

  5. CONSOLIDATED FINANCIAL STATEMENTS UNDER IFRS

    OpenAIRE

    Tănase Alin-Eliodor; Calotă Traian-Ovidiu

    2013-01-01

    This article is focuses on accounting consolidation techniques and the preparation of consolidation worksheets for the components of financial statements (statement of comprehensive income, statement of changes in equity, and financial position). The presented group includes parent company, two subsidiaries (only one fully controlled by the parent company) and a jointly controlled entity. The financial statements are presented under the following standards IFRS 3 Business Combination, IAS 27 ...

  6. FEMA DFIRM Panel Scheme Polygons

    Data.gov (United States)

    Minnesota Department of Natural Resources — This layer contains information about the Flood Insurance Rate Map (FIRM) panel areas. The spatial entities representing FIRM panels are polygons. The polygon for...

  7. 3 CFR - Presidential Signing Statements

    Science.gov (United States)

    2010-01-01

    ... issued statements addressing constitutional or other legal questions upon signing bills into law (signing... of the use of signing statements to raise constitutional objections to statutory provisions. There is no doubt that the practice of issuing such statements can be abused. Constitutional...

  8. Fundamentals of Financial Statements Audit

    OpenAIRE

    World Bank

    2011-01-01

    The purpose of an audit is to enhance the degree of confidence of intended users in the financial statements. The objective of an audit of financial statements is to enable an auditor to express an opinion as to whether the financial statements are prepared, in all material respects, in accordance with International Financial Reporting Standards or another identified financial reporting fr...

  9. Rational Design of Composite Panels

    DEFF Research Database (Denmark)

    Riber, Hans Jørgen

    1996-01-01

    A non-linear structural model for composite panels is presented. The non-linear terms in the lateral displacements are modelled as an additional set of lateral loads acting on the panel. Hence the solution is reduced to that of an equivalent panel with small displacements In order to treat sandwi...

  10. An Official American Thoracic Society Research Statement

    DEFF Research Database (Denmark)

    Slatore, Christopher G; Horeweg, Nanda; Jett, James R;

    2015-01-01

    development of registries that link demographic and nodule characteristics with patient-level outcomes. Methods to share data from registries are also necessary. CONCLUSIONS: This statement may help researchers to develop impactful and innovative research projects and enable funders to better judge research......BACKGROUND: Pulmonary nodules are frequently detected during diagnostic chest imaging and as a result of lung cancer screening. Current guidelines for their evaluation are largely based on low-quality evidence, and patients and clinicians could benefit from more research in this area. METHODS: In...... this research statement from the American Thoracic Society, a multidisciplinary group of clinicians, researchers, and patient advocates reviewed available evidence for pulmonary nodule evaluation, characterized six focus areas to direct future research efforts, and identified fundamental gaps in...

  11. The evolving structure of the uranium market: a discussion with panel introduction

    International Nuclear Information System (INIS)

    At the Eighth International Symposium held by the Uranium Institute in London 1983, the evolving structure of the uranium market was examined. First, individual statements concerning the uranium market were presented by four panel members from Japan, Taiwan, the Federal Republic of Germany and France and then an open discussion of the subject followed. (U.K.)

  12. LLRW panel presentation

    International Nuclear Information System (INIS)

    The Low-Level Radioactive Waste (LLRW) Panel of the Arkansas Department of Health discussed three general issues relative to the operational aspects of a newly developed LLRW disposal facility. The questions addressed and responses comprise this paper. Issue number 1 concerned the financial and regulatory aspects of an operational facility. The second general issue concerned the closure of the site after the end of its operational life. Issue number 2 addressed questions regarding the site operations manual

  13. Panel data analysis using EViews

    CERN Document Server

    Agung, I Gusti Ngurah

    2013-01-01

    A comprehensive and accessible guide to panel data analysis using EViews software This book explores the use of EViews software in creating panel data analysis using appropriate empirical models and real datasets. Guidance is given on developing alternative descriptive statistical summaries for evaluation and providing policy analysis based on pool panel data. Various alternative models based on panel data are explored, including univariate general linear models, fixed effect models and causal models, and guidance on the advantages and disadvantages of each one is given. Panel Data Analysis

  14. Retraction statement: 'Formin-like2 regulates Rho/ROCK pathway to promote actin assembly and cell invasion of colorectal cancer' by Yuanfeng Zeng, Huijun Xie, Yudan Qiao, Jianmei Wang, Xiling Zhu, Guoyang He, Yuling Li, Xiaoli Ren, Feifei Wang, Li Liang and Yanqing Ding.

    Science.gov (United States)

    2016-07-01

    The above article in Cancer Science (doi: 10.1111/cas.12768), published online on 26 October 2015 in Wiley Online Library (http://wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor in Chief, Yusuke Nakamura, and Wiley Publishing Asia Pty Ltd. The retraction has been agreed as Panels +C3 and +Y27632 of SW480 Mock shown in Figure 2a appear to have been taken from the same image, Panels + C3 and +Y27632 of HT29 FMNL2 shown in Figure 2a appear to have been taken from the same image, Panels shFMNL2-1 and shmDial1-1 in Figure 3a appear to have been taken from the same image, shFMNL2-2 and shmDial1-2 in Figure 3a appear to have been taken from the same image, Panels of shFMNL2-1 + shmDial1-1 and shFMNL2-1 + shmDial1-2 of +LPA appear to have been taken from the same image, gel bands of FLAG in Figure 4e appear to have been have been manipulated by erasing gel bands. Reference Zeng Y, Xie H, Qiao Y, Wang J, Zhu X, He G, Li Y, Ren X, Wang F, Liang L, Ding Y. Formin-like2 regulates Rho/ROCK pathway to promote actin assembly and cell invasion of colorectal cancer. Cancer Sci 2015; 106: 1385-93. doi: 10.1111/cas.12768. PMID:27420476

  15. Python Switch Statement

    Directory of Open Access Journals (Sweden)

    2008-06-01

    Full Text Available The Python programming language does not have a built in switch/case control structure as found in many other high level programming languages. It is thought by some that this is a deficiency in the language, and the control structure should be added. This paper demonstrates that not only is the control structure not needed, but that the methods available in Python are more expressive than built in case statements in other high level languages.

  16. Concentrating photovoltaic solar panel

    Science.gov (United States)

    Cashion, Steven A; Bowser, Michael R; Farrelly, Mark B; Hines, Braden E; Holmes, Howard C; Johnson, Jr., Richard L; Russell, Richard J; Turk, Michael F

    2014-04-15

    The present invention relates to photovoltaic power systems, photovoltaic concentrator modules, and related methods. In particular, the present invention features concentrator modules having interior points of attachment for an articulating mechanism and/or an articulating mechanism that has a unique arrangement of chassis members so as to isolate bending, etc. from being transferred among the chassis members. The present invention also features adjustable solar panel mounting features and/or mounting features with two or more degrees of freedom. The present invention also features a mechanical fastener for secondary optics in a concentrator module.

  17. Microsphere Insulation Panels

    Science.gov (United States)

    Mohling, R.; Allen, M.; Baumgartner, R.

    2006-01-01

    Microsphere insulation panels (MIPs) have been developed as lightweight, longlasting replacements for the foam and vacuum-jacketed systems heretofore used for thermally insulating cryogenic vessels and transfer ducts. The microsphere core material of a typical MIP consists of hollow glass bubbles, which have a combination of advantageous mechanical, chemical, and thermal-insulation properties heretofore available only separately in different materials. In particular, a core filling of glass microspheres has high crush strength and low density, is noncombustible, and performs well in soft vacuum.

  18. Photovoltaic panel clamp

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Malcolm P.; Mittan, Margaret Birmingham; Miros, Robert H. J.; Stancel, Robert

    2013-03-19

    A photovoltaic panel clamp includes an upper and lower section. The interface between the assembled clamp halves and the module edge is filled by a flexible gasket material, such as EPDM rubber. The gasket preferably has small, finger like protrusions that allow for easy insertion onto the module edge while being reversed makes it more difficult to remove them from the module once installed. The clamp includes mounting posts or an integral axle to engage a bracket. The clamp also may include a locking tongue to secure the clamp to a bracket.

  19. Cancer

    Science.gov (United States)

    ... Blood tests (which look for chemicals such as tumor markers) Bone marrow biopsy (for lymphoma or leukemia) Chest ... the case with skin cancers , as well as cancers of the lung, breast, and colon. If the tumor has spread ...

  20. Cancer

    Science.gov (United States)

    Cancer begins in your cells, which are the building blocks of your body. Normally, your body forms ... be benign or malignant. Benign tumors aren't cancer while malignant ones are. Cells from malignant tumors ...

  1. Hilar cholangiocarcinoma: expert consensus statement.

    Science.gov (United States)

    Mansour, John C; Aloia, Thomas A; Crane, Christopher H; Heimbach, Julie K; Nagino, Masato; Vauthey, Jean-Nicolas

    2015-08-01

    An American Hepato-Pancreato-Biliary Association (AHPBA)-sponsored consensus meeting of expert panellists met on 15 January 2014 to review current evidence on the management of hilar cholangiocarcinoma in order to establish practice guidelines and to agree consensus statements. It was established that the treatment of patients with hilar cholangiocarcinoma requires a coordinated, multidisciplinary approach to optimize the chances for both durable survival and effective palliation. An adequate diagnostic and staging work-up includes high-quality cross-sectional imaging; however, pathologic confirmation is not required prior to resection or initiation of a liver transplant trimodal treatment protocol. The ideal treatment for suitable patients with resectable hilar malignancy is resection of the intra- and extrahepatic bile ducts, as well as resection of the involved ipsilateral liver. Preoperative biliary drainage is best achieved with percutaneous transhepatic approaches and may be indicated for patients with cholangitis, malnutrition or hepatic insufficiency. Portal vein embolization is a safe and effective strategy for increasing the future liver remnant (FLR) and is particularly useful for patients with an FLR of biliary cancers. PMID:26172136

  2. Video from Panel Discussion with Joseph Fraumeni and David Schottenfeld

    Science.gov (United States)

    Video footage from Panel Discussion with Joseph Fraumeni and David Schottenfeld on Cancer Epidemiology over the Last Half-Century and Thoughts on the Future. The discussion took place on May 11, 2012, when DCEG hosted Dr. Schottenfeld as a Visiting Scholar.

  3. Solar panel parallel mounting configuration

    Science.gov (United States)

    Mutschler, Jr., Edward Charles (Inventor)

    1998-01-01

    A spacecraft includes a plurality of solar panels interconnected with a power coupler and an electrically operated device to provide power to the device when the solar cells are insolated. The solar panels are subject to bending distortion when entering or leaving eclipse. Spacecraft attitude disturbances are reduced by mounting each of the solar panels to an elongated boom made from a material with a low coefficient of thermal expansion, so that the bending of one panel is not communicated to the next. The boom may be insulated to reduce its bending during changes in insolation. A particularly advantageous embodiment mounts each panel to the boom with a single mounting, which may be a hinge. The single mounting prevents transfer of bending moments from the panel to the boom.

  4. Robotized spraying of prefabricated panels

    OpenAIRE

    Peñin, Luis F.; Balaguer, Carlos; Pastor, José M.; Francisco J. Rodríguez; Barrientos, Antonio; Aracil, Rafael

    1998-01-01

    A robotic manufacturing cell of pre-fabricated glass reinforced cement panels for construction industry has been developed by DISAM for the Spanish construction company Dragados, SA. The main contribution of the developed system is the automatic programming and control of the whole plan. The architect's 3D-drawing of the building facade done on a CAD system serves as input. From the CAD design, the optimum facade to panels partition is obtained. In order to manufacture each panel, automatic t...

  5. Reliability Study in Solar Panels

    OpenAIRE

    Español Lifante, Albert

    2012-01-01

    Crystalline silicon Modules are formed by single silicon photovoltaic cells. Since each one of these cells individually contributes to the overall electric power of the panel, the failure of one of them directly affects to its benefits and performance. To Minimize these negative effects, junction boxes with few bypass diodes are usually included in Photovoltaic Solar panels. A still experimental way to built solar panels is to integrate bypass diodes in every single cell, which would in...

  6. ALDS 1978 panel review. [PNL

    Energy Technology Data Exchange (ETDEWEB)

    Hall, D.L. (ed.)

    1979-08-01

    Pacific Northwest Laboratory (PNL) is examining the analysis of large data sets (ALDS). After one year's work, a panel was convened to evaluate the project. This document is the permanent record of that panel review. It consists of edited transcripts of presentations made to the panel by the PNL staff, a summary of the responses of the panel to these presentations, and PNL's plans for the development of the ALDS project. The representations of the PNL staff described various aspects of the project and/or the philosophy surrounding the project. Supporting materials appear in appendixes. 20 figures, 4 tables. (RWR)

  7. Presentation of Consolidated Statement of Cash Flows under IAS 7, Statement of Cash Flows

    OpenAIRE

    Tănase Alin-Eliodor; Calota Traian-Ovidiu

    2013-01-01

    The consolidated financial statements must includ a specific statement, regarding cash flows from all activities of the entity, called „consolidated statement of cash flow”. Information for preparing cash flow statements can be found in all other components of the financial statements, such as financial position, statement of comprehensive income and statement of changes in equity. The cash flow statement shall report cash flows during the period classified by operating, investing and financi...

  8. Statement on virginity testing.

    Science.gov (United States)

    2015-07-01

    Virginity testing (virginity examination) is a gynecological examination that is intended to correlate the status and appearance of the hymen with previous sexual contact to determine whether a female has had or is habituated to sexual intercourse. Virginity examinations are practiced in many countries, often forcibly, including in detention places; on women who allege rape or are accused of prostitution; and as part of public or social policies to control sexuality. The Independent Forensic Expert Group (IFEG) - thirty-five preeminent independent forensic experts from eighteen countries specialized in evaluating and documenting the physical and psychological effects of torture and ill-treatment - released a statement on the practice in December 2014. In its statement, the IFEG outlines the physical and psychological effects of forcibly conducting virginity examinations on females based on its collective experience. The Group assesses whether, based on the effects, forcibly conducted virginity examinations constitute cruel, inhuman, or degrading treatment or torture. Finally, the IFEG addresses the medical interpretation, relevance, and ethical implications of such examinations. The IFEG concludes that virginity examinations are medically unreliable and have no clinical or scientific value. These examinations are inherently discriminatory and, in almost all instances, when conducted forcibly, result in significant physical and mental pain and suffering, thereby constituting cruel, inhuman and degrading treatment or torture. When virginity examinations are forcibly conducted and involve vaginal penetration, the examination should be considered as sexual assault and rape. Involvement of health professionals in these examinations violates the basic standards and ethics of the professions. PMID:26048511

  9. Panel summary report

    International Nuclear Information System (INIS)

    Previous Advisory Group Meetings have led to IAEA Technical Reports No.15=5 (1974) on thermal discharge, 118 (1970) and 169 (1975) on sampling, storage and analysis methods for marine radioactivity studies, 167 (1975) on design of marine biological studies permitting comparative evaluation, and 172 (1976) on the effects of ionizing radiation on aquative organisms and eco-systems. The aim of the present report was a bringing into perspective not only problems designing radioecological experiments but to describe reliable experimental methodology suitable for a successful evaluation of radioactivity cycling, and of the effects of such radioactive additions to aquatic environments, as a result of nuclear activities. Specific examples are described. Individual studies presented to the Panel have been treated in detail, and constitute 19 separate INIS entries

  10. Atomic liability panel

    International Nuclear Information System (INIS)

    It is generally recognized that the lack of adequate rules and accepted definitions of liability in the case of nuclear accidents constitutes a serious drawback to the growth of the atomic energy industry. This applies both t o national undertakings and, more particularly, to bilateral or international operations such as those carried out under the auspices of IAEA. The problems will grow even more complicated if countries adopt differing standards. The initial programme of IAEA therefore stresses the need for the establishment of international standards and definitions of areas of responsibility which would do much to harmonize national practices now being formulated in many countries. In order to initiate studies of this problem, the Director General has decided t o call a number of experts, representing various legal systems, together, and entrust them with the task of examining this question. He has appointed Ambassador Paul Ruegger (Switzerland) as Chairman of the panel

  11. Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement.

    Science.gov (United States)

    Husereau, Don; Drummond, Michael; Petrou, Stavros; Carswell, Chris; Moher, David; Greenberg, Dan; Augustovski, Federico; Briggs, Andrew H; Mauskopf, Josephine; Loder, Elizabeth

    2013-06-01

    Economic evaluations of health interventions pose a particular challenge for reporting. There is also a need to consolidate and update existing guidelines and promote their use in a user friendly manner. The Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement is an attempt to consolidate and update previous health economic evaluation guidelines efforts into one current, useful reporting guidance. The primary audiences for the CHEERS statement are researchers reporting economic evaluations and the editors and peer reviewers assessing them for publication. The need for new reporting guidance was identified by a survey of medical editors. A list of possible items based on a systematic review was created. A two round, modified Delphi panel consisting of representatives from academia, clinical practice, industry, government, and the editorial community was conducted. Out of 44 candidate items, 24 items and accompanying recommendations were developed. The recommendations are contained in a user friendly, 24 item checklist. A copy of the statement, accompanying checklist, and this report can be found on the ISPOR Health Economic Evaluations Publication Guidelines Task Force website ( www.ispor.org/TaskForces/EconomicPubGuidelines.asp). We hope CHEERS will lead to better reporting, and ultimately, better health decisions. To facilitate dissemination and uptake, the CHEERS statement is being co-published across 10 health economics and medical journals. We encourage other journals and groups, to endorse CHEERS. The author team plans to review the checklist for an update in five years. PMID:23526140

  12. WMO statement on the status of the global climate in 2003

    International Nuclear Information System (INIS)

    Since 1993, the World Meteorological Organization (WMO), through the Commission for Climatology and in cooperation with its Members, has issued annual statements on the status of the global climate. This year's statement describes the climatic conditions, including extreme weather events, for the year 2003 and provides a historical perspective on some of the variability and trends that have occurred since the nineteenth century. The statements complement the periodic assessments of the WMO/United Nations Environment Programme (UNEP) Intergovernmental Panel on Climate Change (IPCC), which provide valuable input to national and international negotiations. The information contained in this statement enhances the scientific understanding of the changes in climate and the associated impacts that have occurred in the past, making it possible to improve on our projections for the future

  13. [Cancer].

    Science.gov (United States)

    de la Peña-López, Roberto; Remolina-Bonilla, Yuly Andrea

    2016-09-01

    Cancer is a group of diseases which represents a significant public health problem in Mexico and worldwide. In Mexico neoplasms are the second leading cause of death. An increased morbidity and mortality are expected in the next decades. Several preventable risk factors for cancer development have been identified, the most relevant including tobacco use, which accounts for 30% of the cancer cases; and obesity, associated to another 30%. These factors, in turn, are related to sedentarism, alcohol abuse and imbalanced diets. Some agents are well knokn to cause cancer such as ionizing radiation, viruses such as the papilloma virus (HPV) and hepatitis virus (B and C), and more recently environmental pollution exposure and red meat consumption have been pointed out as carcinogens by the International Agency for Research in Cancer (IARC). The scientific evidence currently available is insufficient to consider milk either as a risk factor or protective factor against different types of cancer. PMID:27603890

  14. Plane and parabolic solar panels

    OpenAIRE

    Sales, J. H. O.; Suzuki, A.T.

    2009-01-01

    We present a plane and parabolic collector that absorbs radiant energy and transforms it in heat. Therefore we have a panel to heat water. We study how to increment this capture of solar beams onto the panel in order to increase its efficiency in heating water.

  15. Strong increase of solar panels

    International Nuclear Information System (INIS)

    The number of installed solar panels in 2011 has increased again. 40 megawatt of new panels have been installed. This increase is twice as high as the year before. The production of solar power increased to 90 million kWh in 2011 as a result of this expansion. However, the share of solar power in total energy use is still very limited.

  16. MLA Statement of Professional Ethics.

    Science.gov (United States)

    ADE Bulletin, 2002

    2002-01-01

    Intends for this statement to embody reasonable norms for ethical conduct in teaching, research, and related public service activities in the modern languages and literatures. Lists seven governing premises of the statement. Examines ethical conduct in academic relationships, discussing obligations to students, colleagues, staff members, the…

  17. Aerospace Education. NSTA Position Statement

    Science.gov (United States)

    National Science Teachers Association (NJ1), 2008

    2008-01-01

    National Science Teachers Association (NSTA) has developed a new position statement, "Aerospace Education." NSTA believes that aerospace education is an important component of comprehensive preK-12 science education programs. This statement highlights key considerations that should be addressed when implementing a high quality aerospace education…

  18. Reading and understanding financial statements.

    Science.gov (United States)

    White, Joseph P

    2005-01-01

    Feeling comfortable reading and understanding financial statements is critical to the success of healthcare executives and physicians involved in management. Businesses use three primary financial statements: a balance sheet represents the equation, Assets = Liabilities + Equity; an income statement represents the equation, Revenues - Expenses = Net Income; a statement of cash flows reports all sources and uses of cash during the represented period. The balance sheet expresses financial indicators at one particular moment in time, whereas the income statement and the statement of cash flows show activity that occurred over a stretch of time. Additional information is disclosed in attached footnotes and other supplementary materials. There are two ways to prepare financial statements. Cash-basis accounting recognizes revenue when it is received and expenses when they are paid. Accrual-basis accounting recognizes revenue when it is earned and expenses when they are incurred. Although cash-basis is acceptable, periodically using the accrual method reveals important information about receivables and liabilities that could otherwise remain hidden. Become more engaged with your financial statements by spending time reading them, tracking key performance indicators, and asking accountants and financial advisors questions. This will help you better understand your business and build a successful future. PMID:16095076

  19. United States panel presentations

    International Nuclear Information System (INIS)

    Before I begin I have to make a disclaimer. That is that I am going to be talking about public perception because I think that is very important. But I do not want to give the impression that I think the public is wrong. I happen to agree with the public's perception of nuclear power, and I want to make that clear. I do not like the current generation of nuclear plants as I have made clear in many statements that I have made. On the other hand, in the long term, I feel that we have only two choices on the supply side, and that is nuclear power and solar electricity. And although I think solar electricity has the best chance, I am realistic enough to know that technologies do not always work the way I want. And so I think it is necessary to have at least some kind of nuclear option available. On the other hand, I do not think just any kind of nuclear technology will do. I want to talk to you about the conditions that I think you have to take into account when you try to design reactors that are publicly acceptable. I look at this as an insurance policy. Again, I do not want to be misquoted: I think nuclear power should be considered as an insurance policy, not as our first line of defense. Having made those disclaimers, what we need to do is set out a problem statement. The problem statement I set out is, 'How could one design and demonstrate a nuclear reactor that would regain public confidence in the United States, if one chose to do that?' By regaining confidence, I mean regaining sufficient confidence to site reactors at a number of locations. It is a pretty heavy task because the public cannot judge the technical issues. They have to judge the players by their characters and their histories, just as the way we calibrate anyone that knows things that we do not. I have three theses that I think are crucial. The first is that people do not believe in the claims of advocates, of any point of view, not just nuclear power, once the advocates have been proved wrong on

  20. DEGRO practical guidelines for radiotherapy of breast cancer I. Breast-conserving therapy

    International Nuclear Information System (INIS)

    Background: The present paper is an update of the practical guidelines for radiotherapy of breast cancer published in 2006 by the breast cancer expert panel of the German Society of Radiation Oncology (DEGRO). These recommendations have been elaborated on the basis of the S3 guidelines of the German Cancer Society that were revised in March 2007 by an interdisciplinary panel. Methods: The DEGRO expert panel performed a comprehensive survey of the literature, comprising lately published meta-analyses, data from recent randomized trials and guidelines of international breast cancer societies, referring to the criteria of evidence-based medicine. In addition to the more general statements of the German Cancer Society, this paper emphasizes specific radiotherapeutic aspects. It is focused on radiotherapy after breast-conserving surgery. Technique, targeting, and dose are described in detail. Results: Postoperative radiotherapy significantly reduces rates of local recurrence. The more pronounced the achieved reduction is, the more substantially it translates into improved survival. Four prevented local recurrences result in one avoided breast cancer death. This effect is independent of age. An additional boost provides a further absolute risk reduction for local recurrence irrespective of age. Women > 50 years have a hazard ratio of 0.59 in favor of the boost. For DCIS, local recurrence was 2.4% per patient year even in a subgroup with favorable prognostic factors leading to premature closure of the respective study due to ethical reasons. For partial-breast irradiation as a sole method of radiotherapy, results are not yet mature enough to allow definite conclusions. Conclusion: After breast-conserving surgery, whole-breast irradiation remains the gold standard of treatment. The indication for boost irradiation should no longer be restricted to women ≤ 50 years. Partial-breast irradiation is still an experimental treatment and therefore discouraged outside controlled

  1. [The ALANAM statement on public health policy].

    Science.gov (United States)

    Goic, Alejando; Armas, Rodolfo

    2010-12-01

    The ALANAM (Association of Latin American National Academies of Medicine) statement on public health policy, issued following its 19th Congress, held October 28–30, 2010, in Santiago, Chile, declares that cardiovascular diseases, cancer, accidents and violence are the leading causes of death in the region, while in several of its member nations, emergent and re-emergent infectious diseases, malnutrition, and mother-child illnesses remain prevalent. The statement calls attention to the lack of functioning water supply and sewage systems in many villages and rural areas. After describing the social causes of the present state of public health in Latin America (poverty levels reaching upwards of 44% of the total population, or some 110 million people), it calls on governments, first, to spare no efforts in the task of eradicating extreme poverty in the short-term, and poverty in the long-term. Second, considering that about 15 million 3-to-6 year-olds have no access to education, it recommends extending educational services to these children, and to improve the quality of existing pre-school and primary education. Third, the statement calls for universal health care coverage and for equal access to good quality medical care for everyone, and for programs aimed at promoting healthy personal habits and self-care. In this regard, it also recommends that disease prevention programs be sustained over time, that national sanitary objectives be defined, and that its results be periodically reviewed. Fourth, it recommends that primary health care be extended to everyone, and that it be enhanced by improving coverage and coordination with secondary and tertiary level health care institutions. The statement lays special stress on the need for adopting public health policies aimed at lowering the cost of medicines; to this end, it calls for the creation of an official list of generic drugs. The statement ends by calling on governments to support public health research as a

  2. High value of the radiobiological parameter Dq correlates to expression of the transforming growth factor beta type II receptor in a panel of small cell lung cancer cell lines

    DEFF Research Database (Denmark)

    Hougaard, S; Krarup, M; Nørgaard, P; Damstrup, L; Spang-Thomsen, M; Poulsen, H S

    1998-01-01

    Our panel of SCLC cell lines have previously been examined for their radiobiological characteristics and sensitivity to treatment with TGF beta 1. In this study we examined the possible correlations between radiobiological parameters and the expression of the TGF beta type II receptor (TGF beta...... role for the repair of radiation induced DNA damage in SCLC....

  3. Modelling Profitability of Banks by Using Dynamic Panel Data Estimation Method

    Directory of Open Access Journals (Sweden)

    Laurynas Naruševičius

    2014-03-01

    Full Text Available Purpose – to find and assess connection between banking sector profitability and real economy data, using panel data, and to display analysis capabilities of dynamic panel data estimation methods.Design/methodology/approach – a panel, or longitudinal data set, consists of a sequence of observations, repeated through time on a set of statistical units. Panel data and their estimation methods are frequently used in various economic research, as it gives more information than pure cross-section or time series data.Findings – dynamic panel data estimation methods are used to study relationship between income statement items (net interest income, net fee and commission income and operating expenses and macroeconomic variables. Model estimation shows that included macroeconomic variables are significant and there is interaction between banks profitability and real economy. Net interest income are found to be dependent on real investment and short term interest rate, net fee and commission income reacts to changes in real gross domestic product (GDP and operating expenses are connected to real GDP and compensation per employee.Practical implications – the model is used to estimate income statement items changes after the external forecasted macroeconomic impact. The forecasts indicate that banks profitability reacts to changes in macroeconomic situation.Research type: case study.

  4. Exascale Workshop Panel Report Meeting

    Energy Technology Data Exchange (ETDEWEB)

    Khaleel, Mohammad A.

    2010-07-01

    The Exascale Review Panel consists of 12 scientists and engineers with experience in various aspects of high-performance computing and its application, development, and management. The Panel hear presentations by several representatives of the workshops and town meetings convened over the past few years to examine the need for exascale computation capability and the justification for a U.S. Department of Energy (DOE) program to develop such capability. This report summarizes information provided by the presenters and substantial written reports to the Panel in advance of the meeting in Washington D.C. on January 19-20, 2010. The report also summarizes the Panel's conclusions with regard to the justification of a DOE-led exascale initiative.

  5. a spatial panel data analysis

    OpenAIRE

    Lottmann, Franziska

    2012-01-01

    This paper analyzes determinants for regional differences in German unemployment rates. We specify a spatial panel model to avoid biased and inefficient estimates due to spatial dependence. Additionally, we control for temporal dynamics in the data. Our study covers the whole of Germany as well as East andWest Germany separately. We exploit district-level data on 24 possible explanatory variables for the period from 1999 until 2007. Our results suggest that the spatial dynamic panel model is ...

  6. Reminder - Equal Opportunities Advisory Panel

    CERN Multimedia

    HR Department

    2007-01-01

    At its meeting on 7 December 2006, the Standing Concertation Committee also took note of the nomination of a fourth new member of the Panel: Wisla Carena. The present composition of the Panel (appointed ad personam) is now as follows: Tiziano Camporesi (Chairperson), Wisla Carena, Pierre Charrue, Sue Foffano, Josi Schinzel (Equal Opportunities Officer), Markus Nordberg, Christine Petit-Jean-Genaz and Elena Wildner. Human Resources Department Tel. 74480

  7. Lists of environmental statements projects

    International Nuclear Information System (INIS)

    The document is a collection of five lists of the Environmental Statements Projects related to nuclear power reactors, consumer products in which by-product radionuclides may be used, ERDA facilities, and, for the Department of Housing and Urban Development, Modular Integrated Utilities Systems. The lists are arranged by (1) Project name, (2) Project docket number, (3) NRC Environmental Project Manager, (4) ORNL Task Group Leader, and (5) ORNL editor. In each list, the first issue date listed for each project is the issue date of its Draft Environmental Statement (DES), and the second issue date is that of the Final Environmental Statement (FES). The lists will be updated as the Environmental Statements Project continues. (U.S.)

  8. Basic statements of relativity theory

    OpenAIRE

    Wolfgang Muschik

    2010-01-01

    Some basic statements of relativity theory, starting out with geometry and observers up to Einstein's field equations, are collected in a systematical order without any proof, to serve as a short survey of tools and results.

  9. Financial statement and final accounts

    OpenAIRE

    ČERNÁ, Ilona

    2011-01-01

    The main task of accounting is to inform truthfully and accurately show business assets, the sources from which assets were acquired and the financial situation - the economic result for a certain period of time. These users will find information in public documents of final accounts, which are made statements - balance sheet, profit and loss account and the annex to these financial statements. To ensure the correctness and completeness of the data in the accounting process is an important ba...

  10. Inflammatory Breast Cancer

    Science.gov (United States)

    ... breast cancer: consensus statement for standardized diagnosis and treatment. Annals of Oncology 2011; 22(3):515-523. [PubMed Abstract] Fouad TM, Kogawa T, Reuben JM, Ueno NT. The role of inflammation in inflammatory breast cancer. Advances in Experimental Medicine and Biology 2014; 816:53-73. [PubMed ...

  11. Financial Report - Financial Statements of Company

    OpenAIRE

    Novotná, Eliška

    2014-01-01

    This thesis deals with the closing of books and the final accounts, or more precisely final accounts in a broader sense, of the business entity in the Czech Republic. The theoretical part focuses on the preparatory work before closing the books that lead to the preparation of financial statements, it means the balance sheet, income statement, notes to the financial statements, alternatively cash flow statement and statement of changes in the equity. Preparatory works mean such as inventory...

  12. OCAW statement of principles

    International Nuclear Information System (INIS)

    The principal concern of the Oil, Chemical and Atomic Workers Union is that the health impact that the mining of uranium has on our members. The US Public Health Service has determined through mortality studies that the number one cause of death among uranium miners is lung cancer. It was also determined that exposure to radon daughters and mine dust correlates with the lung cancer experience of uranium miners. Data from the US Mine Safety and Health Administration has also shown that not only uranium underground miners, but all underground miners, are exposed to radon daughters - especially underground miners in the Rocky Mountain region. Our Union has maintained a consistent posture in relation to carcinogens in the workplace - that is, exposure to cancer-causing agents should be limited to the lowest feasible level. OCAW has interpreted lowest feasible level as the lower limit of detection of the collection and analytical method used to detect the carcinogen. Our posture is based on the available scientific information on carcinogenesis

  13. Capital Structure and Corporate Performance in Nigeria Petroleum Industry: Panel Data Analysis

    OpenAIRE

    Dare F. David; Sola Olorunfemi

    2010-01-01

    Problem statement: The actual impact of capital structure on corporate performance in Nigeria has been a major problem among researchers that has not been resolved. Approach: The study looks at the impact of capital structure on corporate performance in the Nigerian Petroleum Industry. Results: The study employed panel data analysis by using Fixed-effect estimation, Random-effect estimation and Maximum likelihood estimation. It was found out that there was positive relationship between earnin...

  14. A Position Statement on Optimizing the Role of Oncoplastic Breast Surgery

    OpenAIRE

    Andree, Christoph; Farhadi, Jian; Goossens, Dennis; Masia, Jaume; Sarfati, Isabelle; Germann, Günter; MacMillan, R. Douglas; Scheflan, Michael; Van Not, Hans-Pieter; Catanuto, Giuseppe; Nava, Maurizio Bruno

    2012-01-01

    Objectives: To propose initiatives and actions that could improve access to and outcomes from oncoplastic breast surgery. Methods: The author group met in May 2010 to draft position statements on key unmet needs in oncoplastic breast surgery and how these may be addressed. At a second meeting in December 2010, the statements were voted upon and adjusted as necessary to achieve unanimous agreement. Results: It was agreed that every patient undergoing breast cancer surgery should be assessed by...

  15. AECB staff response to the environmental impact statement on the concept for disposal of Canada's nuclear fuel waste

    International Nuclear Information System (INIS)

    The Environmental Impact Statement on the Concept for Disposal of Canada's Nuclear Fuel Waste was released in October 1994 in response to the guidelines issued in 1992 by a panel formed to evaluate this concept (Federal Environmental Assessment Review Panel, 1992). This response is primarily a statement of deficiencies and thus focuses on the negative aspects of the Environmental Impact Statement (EIS). The staff review of the EIS was based on the AECB mandate, which is to protect human health and the environment and as such was focused on technical issues in the EIS. These were performance assessment of the multiple barrier system, environmental impacts, concept feasibility, siting, transport and safety as well as general issues o f regulatory policy and criteria. 30 refs

  16. Analysis of 3-panel and 4-panel microscale ionization sources

    International Nuclear Information System (INIS)

    Two designs of a microscale electron ionization (EI) source are analyzed herein: a 3-panel design and a 4-panel design. Devices were fabricated using microelectromechanical systems technology. Field emission from carbon nanotube provided the electrons for the EI source. Ion currents were measured for helium, nitrogen, and xenon at pressures ranging from 10-4 to 0.1 Torr. A comparison of the performance of both designs is presented. The 4-panel microion source showed a 10x improvement in performance compared to the 3-panel device. An analysis of the various factors affecting the performance of the microion sources is also presented. SIMION, an electron and ion optics software, was coupled with experimental measurements to analyze the ion current results. The electron current contributing to ionization and the ion collection efficiency are believed to be the primary factors responsible for the higher efficiency of the 4-panel microion source. Other improvements in device design that could lead to higher ion source efficiency in the future are also discussed. These microscale ion sources are expected to find application as stand alone ion sources as well as in miniature mass spectrometers.

  17. Expert panel on hydrogeology; report to AECL Research (1992)

    International Nuclear Information System (INIS)

    In 1992 AECL Research convened a panel of external hydrogeological experts consisting of P.A. Domenico, G.E. Grisak, and F.W. Schwartz, to review AECL's proposed approach to siting a geological repository in the rocks of the Canadian Shield for the safe disposal of Canada's nuclear fuel wastes. In particular the panel was asked to provide its opinion on 1) the soundness of the technical approach developed to characterize the groundwater flow systems for the purpose of selecting a location for a disposal vault, 2) the validity and effectiveness of the geological case study used to demonstrate the performance assessment methodology based on the hydrogeological conditions observed at the Whiteshell Research Area, and 3) the adequacy of the hydrogeological information that AECL proposes to use in its Environmental Impact Statement (EIS) of the disposal concept. This report presents the findings, conclusions and recommendations of the hydrogeology review panel. The report was submitted to AECL Research in 1992 December. (author). 24 refs., 2 tabs., 4 figs

  18. 7 CFR 1940.968 - Rural Economic Development Review Panel Grant (Panel Grant).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true Rural Economic Development Review Panel Grant (Panel... of Certain Rural Development Programs § 1940.968 Rural Economic Development Review Panel Grant (Panel... associated with a State rural economic development review panel. (b) Objective. The objective of the...

  19. Towards a Next-Generation Sequencing Diagnostic Service for Tumour Genotyping: A Comparison of Panels and Platforms

    Directory of Open Access Journals (Sweden)

    George J. Burghel

    2015-01-01

    Full Text Available Detection of clinically actionable mutations in diagnostic tumour specimens aids in the selection of targeted therapeutics. With an ever increasing number of clinically significant mutations identified, tumour genetic diagnostics is moving from single to multigene analysis. As it is still not feasible for routine diagnostic laboratories to perform sequencing of the entire cancer genome, our approach was to undertake targeted mutation detection. To optimise our diagnostic workflow, we evaluated three target enrichment strategies using two next-generation sequencing (NGS platforms (Illumina MiSeq and Ion PGM. The target enrichment strategies were Fluidigm Access Array custom amplicon panel including 13 genes (MiSeq sequencing, the Oxford Gene Technologies (OGT SureSeq Solid Tumour hybridisation panel including 60 genes (MiSeq sequencing, and an Ion AmpliSeq Cancer Hotspot Panel including 50 genes (Ion PGM sequencing. DNA extracted from formalin-fixed paraffin-embedded (FFPE blocks of eight previously characterised cancer cell lines was tested using the three panels. Matching genomic DNA from fresh cultures of these cell lines was also tested using the custom Fluidigm panel and the OGT SureSeq Solid Tumour panel. Each panel allowed mutation detection of core cancer genes including KRAS, BRAF, and EGFR. Our results indicate that the panels enable accurate variant detection despite sequencing from FFPE DNA.

  20. Towards a Next-Generation Sequencing Diagnostic Service for Tumour Genotyping: A Comparison of Panels and Platforms.

    Science.gov (United States)

    Burghel, George J; Hurst, Carolyn D; Watson, Christopher M; Chambers, Phillip A; Dickinson, Helen; Roberts, Paul; Knowles, Margaret A

    2015-01-01

    Detection of clinically actionable mutations in diagnostic tumour specimens aids in the selection of targeted therapeutics. With an ever increasing number of clinically significant mutations identified, tumour genetic diagnostics is moving from single to multigene analysis. As it is still not feasible for routine diagnostic laboratories to perform sequencing of the entire cancer genome, our approach was to undertake targeted mutation detection. To optimise our diagnostic workflow, we evaluated three target enrichment strategies using two next-generation sequencing (NGS) platforms (Illumina MiSeq and Ion PGM). The target enrichment strategies were Fluidigm Access Array custom amplicon panel including 13 genes (MiSeq sequencing), the Oxford Gene Technologies (OGT) SureSeq Solid Tumour hybridisation panel including 60 genes (MiSeq sequencing), and an Ion AmpliSeq Cancer Hotspot Panel including 50 genes (Ion PGM sequencing). DNA extracted from formalin-fixed paraffin-embedded (FFPE) blocks of eight previously characterised cancer cell lines was tested using the three panels. Matching genomic DNA from fresh cultures of these cell lines was also tested using the custom Fluidigm panel and the OGT SureSeq Solid Tumour panel. Each panel allowed mutation detection of core cancer genes including KRAS, BRAF, and EGFR. Our results indicate that the panels enable accurate variant detection despite sequencing from FFPE DNA. PMID:26351634

  1. Acoustic panels using magnetostrictive Metglas

    Science.gov (United States)

    Gerver, Michael J.; Goldie, James H.; Makseyn, Scott; Oleksy, John; Doherty, John J.; Remington, Paul

    1999-06-01

    Passive barriers to transmission of sound waves at frequencies below 500 Hz require large masses. Active noise cancellation systems, on the other hand, are complicated and expensive. We are developing a method for noise control, using an array of panels of magnetostrictive Metglas, which combines the low mass and flexibility of active noise control with the relatively low cost and simplicity of passive noise control. The method is based on the well known fact that an acoustic panel with a reaction mass, resonant at the frequency of the sound wave, will completely reflect that wave, simulating an infinite mass. By wrapping a coil around each Metglas panel, and terminating the coil in an impedance, the stiffness of the Metglas, and hence the resonant frequency of the panel, can be controlled by varying the terminal impedance. By choosing a terminal impedance which is itself frequency dependent, the panel can be made to resonate, and hence to have effective infinite mass, at all frequencies (over some fairly large range) simultaneously. This generally requires negative impedance, which can be produced by a simple circuit with an amplifier and feedback loop. In effect, the Metglas acts like both microphone and speaker in an active noise control system. Preliminary experimental results will be presented.

  2. 78 FR 20118 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-04-03

    ... Committee: National Cancer Institute Special Emphasis Panel; Cancer Biology and Therapy. Date: April 17... Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  3. 78 FR 25459 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-05-01

    ... Committee: National Cancer Institute Special Emphasis Panel; Cancer Therapy (Omnibus). Date: June 27-28....395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  4. 75 FR 20370 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2010-04-19

    ....395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93...@mail.nih.gov . Name of Committee: National Cancer Institute Special Emphasis Panel, Breast Cancer... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  5. Solar Panel based Milk Pasteurization

    DEFF Research Database (Denmark)

    Nielsen, Kirsten Mølgaard; Pedersen, Tom Søndergaard

    This paper treats the subject of analysis, design and development of the control system for a solar panel based milk pasteurization system to be used in small villages in Tanzania. The analysis deals with the demands for an acceptable pasteurization, the varying energy supply and the low cost, low...... complexity, simple user interface and high reliability demands. Based on these demands a concept for the pasteurization system is established and a control system is developed. A solar panel has been constructed and the energy absorption has been tested in Tanzania. Based on the test, the pasteurization...... system is dimensioned. A functional prototype of the pasteurization facility with a capacity of 200 l milk/hour has been developed and tested. The system is prepared for solar panels as the main energy source and is ready for a test in Tanzania....

  6. Solar Panel based Milk Pasteurization

    DEFF Research Database (Denmark)

    Nielsen, Kirsten Mølgaard; Pedersen, Tom Søndergaard

    2002-01-01

    This paper treats the subject of analysis, design and development of the control system for a solar panel based milk pasteurization system to be used in small villages in Tanzania. The analysis deals with the demands for an acceptable pasteurization, the varying energy supply and the low cost, low...... complexity, simple user interface and high reliability demands. Based on these demands a concept for the pasteurization system is established and a control system is developed. A solar panel has been constructed and the energy absorption has been tested in Tanzania. Based on the test, the pasteurization...... system is dimensioned. A functional prototype of the pasteurization facility with a capacity of 200 l milk/hour has been developed and tested. The system is prepared for solar panels as the main energy source and is ready for a test in Tanzania....

  7. The Conservation of Panel paintings

    DEFF Research Database (Denmark)

    imperative to strengthen scientific research into the production methods, ageing and future behaviour of panel paintings, being an intricate interplay between different materials. A deeper understanding of the processes that adversely affect panel paintings over time will contribute to the improved care and...... damage caused by unstable environmental conditions. Unfortunately, past structural interventions often caused significant damage due to insufficient knowledge of the behaviour of the wood panels, glue and paint layers. Over the last fifty years, the field has developed treatment strategies based on...... interdisciplinary collaboration and on the knowledge of specialist conservators. Most current conservation protocols rely on empirical knowledge of conservators and are not necessarily based on a scientific understanding of the nature and behaviour of wood and paint layers. In order to move the field forward, it is...

  8. Construction of radiation hybrid panels.

    Science.gov (United States)

    Page, John E; Murphy, William J

    2008-01-01

    Whole-genome radiation hybrid (RH) mapping has proven to be a powerful tool for mapping genes and comparing genome architecture. We describe a protocol for constructing RH panels by rescuing irradiated fibroblast donor cells of any mammalian species by polyethylene glycol fusion to a thymidine kinase-deficient hamster cell line. Characterization and expansion of a panel of 90-100 cell lines can be used to map virtually any PCR-based marker that can be distinguished from the recipient hamster genome. The described procedure has been used successfully to create RH panels from diverse mammalian species such as macaques, elephants, alpacas, and armadillos, and may be applicable to nonmammalian vertebrates as well. PMID:18629660

  9. The "Virtual" Panel: A Computerized Model for LGBT Speaker Panels

    Science.gov (United States)

    Beasley, Christopher; Torres-Harding, Susan; Pedersen, Paula J.

    2012-01-01

    Recent societal trends indicate more tolerance for homosexuality, but prejudice remains on college campuses. Speaker panels are commonly used in classrooms as a way to educate students about sexual diversity and decrease negative attitudes toward sexual diversity. The advent of computer-delivered instruction presents a unique opportunity to…

  10. Solar panel truss mounting systems and methods

    Energy Technology Data Exchange (ETDEWEB)

    Al-Haddad, Tristan Farris; Cavieres, Andres; Gentry, Russell; Goodman, Joseph; Nolan, Wade; Pitelka, Taylor; Rahimzadeh, Keyan; Brooks, Bradley; Lohr, Joshua; Crooks, Ryan; Porges, Jamie; Rubin, Daniel

    2016-06-28

    An exemplary embodiment of the present invention provides a solar panel truss mounting system comprising a base and a truss assembly coupled to the base. The truss assembly comprises a first panel rail mount, second panel rail mount parallel to the first panel rail mount, base rail mount parallel to the first and second panel rail mounts, and a plurality of support members. A first portion of the plurality of support members extends between the first and second panel rail mounts. A second portion of the plurality of support members extends between the first panel rail mount and the base rail mount. A third portion of the plurality of support members extends between the second panel rail mount and the base rail mount. The system can further comprise a plurality of connectors for coupling a plurality of photovoltaic solar panels to the truss assembly.

  11. Solar panel truss mounting systems and methods

    Energy Technology Data Exchange (ETDEWEB)

    Al-Haddad, Tristan Farris; Cavieres, Andres; Gentry, Russell; Goodman, Joseph; Nolan, Wade; Pitelka, Taylor; Rahimzadeh, Keyan; Brooks, Bradley; Lohr, Joshua; Crooks, Ryan; Porges, Jamie; Rubin, Daniel

    2015-10-20

    An exemplary embodiment of the present invention provides a solar panel truss mounting system comprising a base and a truss assembly coupled to the base. The truss assembly comprises a first panel rail mount, second panel rail mount parallel to the first panel rail mount, base rail mount parallel to the first and second panel rail mounts, and a plurality of support members. A first portion of the plurality of support members extends between the first and second panel rail mounts. A second portion of the plurality of support members extends between the first panel rail mount and the base rail mount. A third portion of the plurality of support members extends between the second panel rail mount and the base rail mount. The system can further comprise a plurality of connectors for coupling a plurality of photovoltaic solar panels to the truss assembly.

  12. CANCER

    Directory of Open Access Journals (Sweden)

    N. Kavoussi

    1973-09-01

    Full Text Available There are many carcinogenetic elements in industry and it is for this reason that study and research concerning the effect of these materials is carried out on a national and international level. The establishment and growth of cancer are affected by different factors in two main areas:-1 The nature of the human or animal including sex, age, point and method of entry, fat metabolism, place of agglomeration of carcinogenetic material, amount of material absorbed by the body and the immunity of the body.2 The different nature of the carcinogenetic material e.g. physical, chemical quality, degree of solvency in fat and purity of impurity of the element. As the development of cancer is dependent upon so many factors, it is extremely difficult to determine whether a causative element is principle or contributory. Some materials are not carcinogenetic when they are pure but become so when they combine with other elements. All of this creates an industrial health problem in that it is almost impossible to plan an adequate prevention and safety program. The body through its system of immunity protects itself against small amounts of carcinogens but when this amount increases and reaches a certain level the body is not longer able to defend itself. ILO advises an effective protection campaign against cancer based on the Well –equipped laboratories, Well-educated personnel, the establishment of industrial hygiene within factories, the regular control of safety systems, and the implementation of industrial health principles and research programs.

  13. The SRB solar thermal panel

    OpenAIRE

    Benvenuti C.

    2013-01-01

    Can one build a solar thermal collector which reaches 400 °C even without using focusing mirrors? Yes we can, says SRB Energy, a company aiming at industrially producing a flat panel solar collector patented at CERN in 2003. The distinctive feature of this collector is the high efficiency achieved thanks to the vacuum maintained by a getter pump powered by the sun.

  14. Large Scale Glazed Concrete Panels

    DEFF Research Database (Denmark)

    Bache, Anja Margrethe

    2010-01-01

    Factories and finally Lene Tranberg and Bøje Lungård’s Elsinore water purification plant. These buildings have qualities that I would like applied, perhaps transformed or most preferably, if possible, interpreted anew, for the large glazed concrete panels I shall develop. The article is ended and concluded...

  15. ASIST 2003: Part II: Panels.

    Science.gov (United States)

    Proceedings of the ASIST Annual Meeting, 2003

    2003-01-01

    Forty-six panels address topics including women in information science; users and usability; information studies; reference services; information policies; standards; interface design; information retrieval; information networks; metadata; shared access; e-commerce in libraries; knowledge organization; information science theories; digitization;…

  16. Risk-based decisionmaking (Panel)

    Energy Technology Data Exchange (ETDEWEB)

    Smith, T.H.

    1995-12-31

    By means of a panel discussion and extensive audience interaction, explore the current challenges and progress to date in applying risk considerations to decisionmaking related to low-level waste. This topic is especially timely because of the proposed legislation pertaining to risk-based decisionmaking and because of the increased emphasis placed on radiological performance assessments of low-level waste disposal.

  17. Prevalence of pathogenic mutations in cancer predisposition genes among pancreatic cancer patients

    OpenAIRE

    Hu, Chunling; Steven N Hart; William R Bamlet; Moore, Raymond M.; Nandakumar, Kannabiran; Bruce W Eckloff; Lee, Yean K.; Petersen, Gloria M.; Robert R McWilliams; Couch, Fergus J.

    2015-01-01

    The prevalence of germline pathogenic mutations in a comprehensive panel of cancer predisposition genes is not well defined for patients with pancreatic ductal adenocarcinoma (PDAC). To estimate the frequency of mutations in a panel of 22 cancer predisposition genes, 96 patients unselected for a family history of cancer who were recruited to the Mayo Clinic Pancreatic Cancer patient registry over a 12 month period were screened by next-generation sequencing. Fourteen pathogenic mutations in 1...

  18. Use of Internet panels to conduct surveys.

    Science.gov (United States)

    Hays, Ron D; Liu, Honghu; Kapteyn, Arie

    2015-09-01

    The use of Internet panels to collect survey data is increasing because it is cost-effective, enables access to large and diverse samples quickly, takes less time than traditional methods to obtain data for analysis, and the standardization of the data collection process makes studies easy to replicate. A variety of probability-based panels have been created, including Telepanel/CentERpanel, Knowledge Networks (now GFK KnowledgePanel), the American Life Panel, the Longitudinal Internet Studies for the Social Sciences panel, and the Understanding America Study panel. Despite the advantage of having a known denominator (sampling frame), the probability-based Internet panels often have low recruitment participation rates, and some have argued that there is little practical difference between opting out of a probability sample and opting into a nonprobability (convenience) Internet panel. This article provides an overview of both probability-based and convenience panels, discussing potential benefits and cautions for each method, and summarizing the approaches used to weight panel respondents in order to better represent the underlying population. Challenges of using Internet panel data are discussed, including false answers, careless responses, giving the same answer repeatedly, getting multiple surveys from the same respondent, and panelists being members of multiple panels. More is to be learned about Internet panels generally and about Web-based data collection, as well as how to evaluate data collected using mobile devices and social-media platforms. PMID:26170052

  19. COMPARATIVE FINANCIAL STATEMENTS. CONVERGENCE VERSUS DIVERGENCE

    Directory of Open Access Journals (Sweden)

    Nicolae ECOBICI

    2010-09-01

    Full Text Available In this paper I compared the Romanian financial statements with the US GAAP financial statements in terms of two criteria: first the reference period and secondly the shape, structure and content of financial statements. Nowadays the two accounting systems, the French and Anglo-Saxon, tend to harmonize. I will present the convergences and the divergences between the financial statements of Romania, subject to OMFP 3055/2009, in parallel with the Anglo-Saxon accounting system.

  20. In Brief: Geoengineering draft statement

    Science.gov (United States)

    Showstack, Randy

    2009-04-01

    The American Meteorological Society (AMS) has prepared a draft policy statement on geoengineering the climate system, which the AMS Council is considering for approval. The statement notes, “Geoengineering will not substitute for either aggressive mitigation or proactive adaptation. It could contribute to a comprehensive risk management strategy to slow climate change and alleviate its negative impacts, but the potential for adverse and unintended consequences implies a need for adequate research, appropriate regulation, and transparent consideration.” The statement, if adopted, indicates that AMS recommends enhanced research on the scientific and technological potential for geoengineering the climate system; additional study of the historical, ethical, legal, political, and societal aspects of the geoengineering issues; and the development and analysis of policy options to promote transparency and international cooperation in exploring geoengineering options along with restrictions on reckless efforts to manipulate the climate system. AMS is accepting comments on the draft statement until 23 April. For more information, visit http://ametsoc.org/policy/draftstatements/index.html#draft.

  1. Mission Statements: One More Time.

    Science.gov (United States)

    Detomasi, Don

    1995-01-01

    It is argued that well-conceived college and university mission statements can be useful in setting objectives for planning and for public information dissemination and marketing. The experience of the University of Calgary (Alberta) illustrates a successful process of drafting and reaching agreement on such a document. (MSE)

  2. NPT review conference: Australian statement

    International Nuclear Information System (INIS)

    The article contains the text of statement delivered by the leader of the Australian delegation to the Second Nuclear Non-Proliferation Treaty Review Conference in Geneva on August 14, 1980. An outline is given of Australian policy regarding nuclear weapons proliferation

  3. 12 CFR 327.2 - Certified statements.

    Science.gov (United States)

    2010-01-01

    ... known as the quarterly certified statement invoice. Each insured depository institution shall file and certify its quarterly certified statement invoice in the manner and form set forth in this section. (2) The quarterly certified statement invoice shall reflect the institution's risk assignment,...

  4. Retaining Ring Fastener for Solar Panels

    Science.gov (United States)

    Wilson, A. H.

    1983-01-01

    Simple articulating linkage secures solar panels into supporting framework. Five element linkage collapses into W-shape for easy placement into framework, then expands to form rectangle of same dimensions as those of panel.

  5. McArthur River underground exploration program: report of the joint Federal-Provincial panel on uranium mining developments in Northern Saskatchewan

    International Nuclear Information System (INIS)

    A report of the joint federal-provincial panel on uranium mining developments in northern Saskatchewan, on the McArthur River underground exploration program. The proposal to construct the surface and underground facilities required for the exploration and delineation of the McArthur River ore body, and any necessary additional infrastructure has been examined and public hearings have been held. The panel recommends that the underground exploration program as described by Cameco in its Environmental Impact Statement, and as clarified in its written and oral responses to the panel, be allowed to proceed under the conditions described within the report

  6. Grounds of two positions photovoltaic panels

    OpenAIRE

    Castán Fortuño, Fernando

    2008-01-01

    The objective of this Master Thesis is to find the optimum positioning for a two positions photovoltaic panel. Hence, it will be implemented a model in order to optimize the energy of the sun that the photovoltaic panel is receiving by its positioning. Likewise this project will include the comparison with other photovoltaic panel systems as the single position photovoltaics panels. Ultimately, it is also going to be designed a system array for the optimized model of two positions photovoltai...

  7. Use of Internet panels to conduct surveys

    OpenAIRE

    Hays, RD; Liu, H.; Kapteyn, A.

    2015-01-01

    © 2015, Psychonomic Society, Inc. The use of Internet panels to collect survey data is increasing because it is cost-effective, enables access to large and diverse samples quickly, takes less time than traditional methods to obtain data for analysis, and the standardization of the data collection process makes studies easy to replicate. A variety of probability-based panels have been created, including Telepanel/CentERpanel, Knowledge Networks (now GFK KnowledgePanel), the American Life Panel...

  8. International Association for the Study of Lung Cancer Computed Tomography Screening Workshop 2011 Report

    NARCIS (Netherlands)

    Field, John K.; Smith, Robert A.; Aberle, Denise R.; Oudkerk, Matthijs; Baldwin, David R.; Yankelevitz, David; Pedersen, Jesper Holst; Swanson, Scott James; Travis, William D.; Wisbuba, Ignacio I.; Noguchi, Masayuki; Mulshine, Jim L.

    2012-01-01

    The International Association for the Study of Lung Cancer (IASLC) Board of Directors convened a computed tomography (CT) Screening Task Force to develop an IASLC position statement, after the National Cancer Institute press statement from the National Lung Screening Trial showed that lung cancer de

  9. Clinical practice guidelines and consensus statements in oncology--an assessment of their methodological quality.

    Directory of Open Access Journals (Sweden)

    Carmel Jacobs

    Full Text Available BACKGROUND: Consensus statements and clinical practice guidelines are widely available for enhancing the care of cancer patients. Despite subtle differences in their definition and purpose, these terms are often used interchangeably. We systematically assessed the methodological quality of consensus statements and clinical practice guidelines published in three commonly read, geographically diverse, cancer-specific journals. Methods Consensus statements and clinical practice guidelines published between January 2005 and September 2013 in Current Oncology, European Journal of Cancer and Journal of Clinical Oncology were evaluated. Each publication was assessed using the Appraisal of Guidelines for Research and Evaluation II (AGREE II rigour of development and editorial independence domains. For assessment of transparency of document development, 7 additional items were taken from the Institute of Medicine's standards for practice guidelines and the Journal of Clinical Oncology guidelines for authors of guidance documents. METHODS: Consensus statements and clinical practice guidelines published between January 2005 and September 2013 in Current Oncology, European Journal of Cancer and Journal of Clinical Oncology were evaluated. Each publication was assessed using the Appraisal of Guidelines for Research and Evaluation II (AGREE II rigour of development and editorial independence domains. For assessment of transparency of document development, 7 additional items were taken from the Institute of Medicine's standards for practice guidelines and the Journal of Clinical Oncology guidelines for authors of guidance documents. FINDINGS: Thirty-four consensus statements and 67 clinical practice guidelines were evaluated. The rigour of development score for consensus statements over the three journals was 32% lower than that of clinical practice guidelines. The editorial independence score was 15% lower for consensus statements than clinical practice

  10. Bamboo-based Panels for Structural Applications

    Institute of Scientific and Technical Information of China (English)

    CHENXuhe; WANGZheng

    2005-01-01

    With technical assistance from INBAR and the Research Institute of Wood Industry of the Chinese Academy of Forestry, the construction of the Pingbian Primary School was completed in 2004,where bamboo plywood panels and laminated beams were used for the roof trusses, sheathing boards and wall panels. This is the first time that bamboo-based panels are used for structural applications.

  11. 7 CFR 2902.19 - Composite panels.

    Science.gov (United States)

    2010-01-01

    .... The designation can be found in the Comprehensive Procurement Guideline, 40 CFR 247.12. EPA provides... 7 Agriculture 15 2010-01-01 2010-01-01 false Composite panels. 2902.19 Section 2902.19 Agriculture... Composite panels. (a) Definitions. (1) Plastic lumber composite panels. Engineered products suitable for...

  12. 30 CFR 77.310 - Control panels.

    Science.gov (United States)

    2010-07-01

    ... posted on or near the control panel of each thermal drying system. (c) Each instrument on the control panel shall be identified by a nameplate or equivalent marking. (d) A plan to control the operation of each thermal dryer system shall be posted at or near the control panel showing a sequence of...

  13. Recent Discoveries on Antwerp Panel Makers' Marks

    DEFF Research Database (Denmark)

    Wadum, Jørgen

    There still exist today uncertainties and misunderstandings in our interpretation of panel makers' marks from early 17th century Antwerp. In the future, panel marks and the panels on which they can be found will certainly render much more information concerning the technology of that time. Still ...

  14. Striations in Plasma Display Panel

    Institute of Scientific and Technical Information of China (English)

    OUYANG Ji-Ting; CAO Jing; MIAO Jin-Song

    2005-01-01

    @@ The phenomenon of striation has been investigated experimentally in a macroscopic ac-plasma display panel (PDP). The relationship between the characteristics of striation and the operation conditions including voltage, frequency, rib, and electrode configuration, etc is obtained experimentally. The origin of the striations is considered to be the ionization waves in the transient positive column near the dielectric surface in the anode area during the discharge, and the perturbation is caused by resonance kinetic effects in inert gas.

  15. Panel 4 - applications to transportation

    Energy Technology Data Exchange (ETDEWEB)

    Nichols, F. [Argonne National Lab., IL (United States); Au, J. [Sundstrand Aerospace, Rockford, IL (United States); Bhattacharya, R. [Universal Energy Systems, Inc., Dayton, OH (United States); Bhushan, B. [Ohio State Univ., Columbus (United States); Blunier, D. [Caterpillar, Inc., Peoria, IL (United States); Boardman, B. [Deere & Co., Moline, IL (United States); Brombolich, L. [Compu-Tec Engineering, Chesterfield, MO (United States); Davidson, J. [Vanderbilt Univ., Nashville, TN (United States); Graham, M. [Northwestern Univ., Evanston, IL (United States); Hakim, N. [Detroit Diesel Corp., MI (United States); Harris, K. [Dubbeldee Harris Diamond Corp., Mt. Arlington, NJ (United States); Hay, R. [Norton Diamond Film, Northboro, MA (United States); Herk, L. [Southwest Research Inst., Southfield, MI (United States); Hojnacki, H.; Rourk, D. [Intelligent Structures Incorporated, Canton, MI (United States); Kamo, R. [Adiabatics, Inc., Columbus, IN (United States); Nieman, B. [Allied-Signal Inc., Des Plaines, IL (United States); O`Neill, D. [3M, St. Paul, MN (United States); Peterson, M.B. [Wear Sciences, Arnold, MD (United States); Pfaffenberger, G. [Allison Gas Turbine, Indianapolis, IN (United States); Pryor, R.W. [Wayne State Univ., Detroit, MI (United States); Russell, J. [Superconductivity Publications, Inc., Somerset, NJ (United States); Syniuta, W. [Advanced Mechanical Technology, Inc., Newton, MA (United States); Tamor, M. [Ford Motor Co., Dearborn, MI (United States); Vojnovich, T. [Dept. of Energy, Washington, DC (United States); Yarbrough, W. [Pennsylvania State Univ., University Park (United States); Yust, C.S. [Oak Ridge National Lab., TN (United States)

    1993-01-01

    The aim of this group was to compile a listing of current and anticipated future problem areas in the transportation industry where the properties of diamond and DLC films make them especially attractive and where the panel could strongly endorse the establishment of DOE/Transportation Industry cooperative research efforts. This section identifies the problem areas for possible applications of diamond/DLC technology and presents indications of current approaches to these problems.

  16. Essays on panel cointegration testing

    OpenAIRE

    Karaman Örsal, Deniz Dilan

    2009-01-01

    Diese Dissertation beinhaltet vier Aufsätze, die zur Literatur der Panelkointegrationsmethodik beitragen. Der erste Aufsatz vergleicht die Eigenschaften der vier Residuen-basierten Panelkointegrationstests von Pedroni (1995, 1999) mit dem Likelihood-basierten Panelkointegrationstest von Larsson et al. (2001) in endlichen Stichproben. Die Simulationsergebnisse zeigen, dass unter den fünf untersuchten Panelkointegrationsteststatistiken die Panel-t Teststatistik von Pedroni (1995, 1999) die best...

  17. Aggregation in Large Dynamic Panels

    OpenAIRE

    Pesaran, Mohammad Hashem; Chudik, Alexander

    2011-01-01

    This paper considers the problem of aggregation in the case of large linear dynamic panels, where each micro unit is potentially related to all other micro units, and where micro innovations are allowed to be cross sectionally dependent. Following Pesaran (2003), an optimal aggregate function is derived, and the limiting behavior of the aggregation error is investigated as N (the number of cross section units) increases. Certain distributional features of micro parameters are also identi...

  18. Consolidated financial statements for fiscal year 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-02-01

    The following overview and accompanying audited financial statements have been prepared for Fiscal Year (FY) 1996 to report the financial position and the results of operations of the Department of Energy. These statements include the consolidated Statement of Financial Position and the consolidated Statement of Operations and Changes in Net Position. The statements have been prepared in accordance with the Office of Management and Budget Bulletin No. 94-01, Form and Content for Agency Financial Statements, and were developed in accordance with the hierarchy of accounting standards described therein. The overview provides a narrative on the Department of Energy`s mission, activities, and accomplishments. Utilizing performance measures as the primary vehicle for communicating Departmental accomplishments and results, this overview discusses the most significant measures while others are discussed in the supplemental information to the financial statements.

  19. Statement on injectable contraception.

    Science.gov (United States)

    1982-12-01

    whether DMPA or NET-EN caused these cancers or instead failed to prevent them. Despite more than 18 years of use and an estimated 13 million women who have ever used DMPA or NET-EN, no case has been recorded of an endometrial malignancy in women so exposed. There is no evidence at this stage of a causal association, either anecdotal or scientific. No evidence of an increased risk of malignant and premalignant disease of the uterine cervix has been found in DMPA users. There is sufficient evidence from investigations in several countries that DMPA and NET-EN may increase both milk production and the duration of lactation. The only clinical metabolic effect attributed to DMPA is weight gain. NET-EN and DMPA are associated with disruption of the menstrual cycle and irregular bleeding. PMID:12338511

  20. High Efficiency, High Density Terrestrial Panel. [for solar cell modules

    Science.gov (United States)

    Wohlgemuth, J.; Wihl, M.; Rosenfield, T.

    1979-01-01

    Terrestrial panels were fabricated using rectangular cells. Packing densities in excess of 90% with panel conversion efficiencies greater than 13% were obtained. Higher density panels can be produced on a cost competitive basis with the standard salami panels.

  1. 77 FR 67015 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2012-11-08

    ... Committee: National Cancer Institute Special Emphasis Panel NCI Omnibus and Cancer Therapy. Date: November... Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  2. 78 FR 8157 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-02-05

    ... Committee: National Cancer Institute Special Emphasis Panel; Provocative Questions: Cancer Therapy and... Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  3. 78 FR 36200 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-06-17

    ... Committee: National Cancer Institute Special Emphasis Panel; Cancer Biology and Therapy. Date: June 24, 2013... Research; 93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  4. 78 FR 59362 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-09-26

    ... Committee: National Cancer Institute Special Emphasis Panel Provocative Questions--Group D: Cancer Therapy... Research; 93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  5. 78 FR 50065 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-08-16

    ...@mail.nih.gov . Name of Committee: National Cancer Institute Special Emphasis Panel; Cancer Therapy... Prevention Research; 93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  6. 78 FR 58321 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-09-23

    ... Emphasis Panel, Provocative Questions: Cancer Therapy & Outcomes. Date: November 7-8, 2013. Time: 8:00 a.m..., Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93.398... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  7. 76 FR 50487 - National Cancer Institute Notice of Closed Meetings

    Science.gov (United States)

    2011-08-15

    ... Committee: National Cancer Institute Special Emphasis Panel; NCI SPORE in Childhood ALL, Skin, Brain, Lung....395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93... HUMAN SERVICES National Institutes of Health National Cancer Institute Notice of Closed...

  8. 75 FR 21002 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2010-04-22

    ...; 93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer... Panel, SPORE in Lymphoma and Breast Cancer. Date: June 15-16, 2010. Time: 5 p.m. to 5 p.m. Agenda: To... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  9. 75 FR 3239 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2010-01-20

    ... Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93.398, Cancer Research... Special Emphasis Panel, Basal-like Breast Cancer Assay. Date: March 10, 2010. Time: 8 a.m. to 7 p.m... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  10. Analytical comparison of three stiffened panel concepts

    Science.gov (United States)

    Maloney, Jill M.; Wu, K. Chauncey; Robinson, James C.

    1995-01-01

    Three stiffened panel concepts are evaluated to find optimized designs for integral stiffeners in the barrels of Reusable Launch Vehicle fuel tanks. The three panel concepts considered are a T-stiffened panel, a panel with one blade stiffener centered between each pair of T-stiffeners, and a panel with two blade stiffeners equally spaced between each pair of T-stiffeners. The panels are optimized using PASCO for a range of compressive loads, and the computed areal weight for each panel is used to compare the concepts and predict tank weights. The areal weight of the T-stiffened panel with one blade is up to seven-percent lower than the other panel concepts. Two tank construction methods are compared for a representative tank design with three barrels. In the first method, 45-degree circumferential sections of a barrel are each designed to carry the same maximum load in the barrel. In the second method, each barrel section is designed for the maximum load in that section. Representative tanks designed with the first method are over 250 lb heavier than tanks designed using the second method. Optimized panel designs and areal weights are also computed for variation of the nominal panel length and skin thickness.

  11. Highly stretchable, transparent ionic touch panel

    Science.gov (United States)

    Kim, Chong-Chan; Lee, Hyun-Hee; Oh, Kyu Hwan; Sun, Jeong-Yun

    2016-08-01

    Because human-computer interactions are increasingly important, touch panels may require stretchability and biocompatibility in order to allow integration with the human body. However, most touch panels have been developed based on stiff and brittle electrodes. We demonstrate an ionic touch panel based on a polyacrylamide hydrogel containing lithium chloride salts. The panel is soft and stretchable, so it can sustain a large deformation. The panel can freely transmit light information because the hydrogel is transparent, with 98% transmittance for visible light. A surface-capacitive touch system was adopted to sense a touched position. The panel can be operated under more than 1000% areal strain without sacrificing its functionalities. Epidermal touch panel use on skin was demonstrated by writing words, playing a piano, and playing games.

  12. Flat panel display - Impurity doping technology for flat panel displays

    International Nuclear Information System (INIS)

    Features of the flat panel displays (FPDs) such as liquid crystal display (LCD) and organic light emitting diode (OLED) display, etc. using low temperature poly-Si (LTPS) thin film transistors (TFTs) are briefly reviewed comparing with other FPDs. The requirements for fabricating TFTs used for high performance FPDs and system on glass (SoG) are addressed. This paper focuses on the impurity doping technology, which is one of the key technologies together with crystallization by laser annealing, formation of high quality gate insulator and gate-insulator/poly-Si interface. The issues to be solved in impurity doping technology for state of the art and future TFTs are clarified

  13. Flat panel display - Impurity doping technology for flat panel displays

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Toshiharu [Advanced Technology Planning, Sumitomo Eaton Nova Corporation, SBS Tower 9F, 10-1, Yoga 4-chome, Setagaya-ku, 158-0097 Tokyo (Japan)]. E-mail: suzuki_tsh@senova.co.jp

    2005-08-01

    Features of the flat panel displays (FPDs) such as liquid crystal display (LCD) and organic light emitting diode (OLED) display, etc. using low temperature poly-Si (LTPS) thin film transistors (TFTs) are briefly reviewed comparing with other FPDs. The requirements for fabricating TFTs used for high performance FPDs and system on glass (SoG) are addressed. This paper focuses on the impurity doping technology, which is one of the key technologies together with crystallization by laser annealing, formation of high quality gate insulator and gate-insulator/poly-Si interface. The issues to be solved in impurity doping technology for state of the art and future TFTs are clarified.

  14. Global Proteome Analysis of the NCI-60 Cell Line Panel

    Directory of Open Access Journals (Sweden)

    Amin Moghaddas Gholami

    2013-08-01

    Full Text Available The NCI-60 cell line collection is a very widely used panel for the study of cellular mechanisms of cancer in general and in vitro drug action in particular. It is a model system for the tissue types and genetic diversity of human cancers and has been extensively molecularly characterized. Here, we present a quantitative proteome and kinome profile of the NCI-60 panel covering, in total, 10,350 proteins (including 375 protein kinases and including a core cancer proteome of 5,578 proteins that were consistently quantified across all tissue types. Bioinformatic analysis revealed strong cell line clusters according to tissue type and disclosed hundreds of differentially regulated proteins representing potential biomarkers for numerous tumor properties. Integration with public transcriptome data showed considerable similarity between mRNA and protein expression. Modeling of proteome and drug-response profiles for 108 FDA-approved drugs identified known and potential protein markers for drug sensitivity and resistance. To enable community access to this unique resource, we incorporated it into a public database for comparative and integrative analysis (http://wzw.tum.de/proteomics/nci60.

  15. Optimum design of composite panel with photovoltaic-thermo module. Absorbing effect of cooling panel; Hikari netsu fukugo panel no saiteki sekkei. Reikyaku panel no kyunetsu koka

    Energy Technology Data Exchange (ETDEWEB)

    Sato, M.; Kikuchi, S.; Tani, T. [Science University of Tokyo, Tokyo (Japan); Kadotani, K.; Imaizumi, H. [Komatsu Ltd., Tokyo (Japan)

    1996-10-27

    The composite panel with photovoltaic-thermo module becomes higher in energy-saving than the conventional air-conditioning system by the independent radiational heating and cooling effect obtained when the generating panel using a solar cell module is combined with the heating and cooling panel using a thermo-element module. The output of a solar cell module can be directly used because the solar cell module operates in AC. This paper reports the relation between the absorbed value and power consumption of the cooling panel, while paying attention to the cooling panel. The performance coefficient of the maximum absorbed value from an non-absorbing substance to a cooling panel is 2 to 3. Assume that the cooling panel during non-adiabatic operation is operated using a solar cell module of 800 W/m{sup 2} in solar intensity and 15% in conversion efficiency. The cooling-surface temperature difference is 12.12 K, and the maximum absorbed value of a non-absorbing substance to a cooling panel is 39.12 W/m{sup 2}. The absorbed value of the outer temperature to the cooling panel is 74.4 W/m{sup 2}, and each performance coefficient is 3.26 and 0.62. The absorbed value must be calculated for evaluation from the cooling-surface temperature difference measured directly from the cooling panel. 4 refs., 8 figs., 1 tab.

  16. 1-3 piezocomposite SmartPanels

    Science.gov (United States)

    Fiore, Daniel; Gentilman, Richard L.; Pham-Nguyen, Hong; Serwatka, William J.; McGuire, Patrick T.; Near, Craig D.; Bowen, Leslie J.

    1997-05-01

    Piezocomposite SmartPanelsTM, consisting of 1-3 actuators and pressure sensors and net-shape-molded PZT accelerometers in a large area low profile panel, have been fabricated at Materials Systems Inc. and evaluated at the Naval Research Laboratory. Single layer and two-layer 100 X 100 mm SmartPanels have been tested for sensor sensitivities, actuator authority, surface displacement uniformity, and sensor-actuator coupling. Multilayer GRP circuits boards are used both as stiff faceplates and to provide electrical connections and ground planes. The SmartPanel technology has recently been scaled up to 250 X 250 mm devices. SmartPanels draw upon PZT (lead zirconate titanate) ceramic injection molding technology, which is used to produce cost-effective and robust 1-3 piezoelectric ceramic-polymer composite materials. The 1-3 materials are used extensively for SonoPanelTM transducers in a number of sensor and actuator applications. SonoPanels have been qualified for US Navy applications, based on successful completion of pressure and shock tests, and are currently being scaled up from 250 X 250 mm to 750 X 750 mm panels. Several applications for SmartPanels and SonoPanels are described, including conformable transducers, multielement arrays, pressure sensors, and velocity sensors.

  17. Current practice with endoscopic submucosal dissection in Europe: position statement from a panel of experts

    DEFF Research Database (Denmark)

    Deprez, P H; Bergman, J J; Meisner, S;

    2010-01-01

    : good quality imaging, experienced histopathologist following the Japanese criteria (2-mm sections, micrometric invasion, vessel and lymphatic infiltration, etc), and dedicated endoscopic follow-up. Moreover, minimum training requirements were also defined: knowledge in indications and instruments...

  18. Introduction statement at the panel discussion [contributed by James L. Snelgrove, ANL

    International Nuclear Information System (INIS)

    I just wanted to say a few words about the fuel demonstration part of the RERTR program, especially about our near-term activities. In the near-term we are considering three types of demonstrations. One of those is the irradiation of individual fuel elements in the ORR. These elements are to be essentially identical to the current ORR elements except that the enrichment will be 45% and the uranium density in the fuel meat will be somewhere in the neighborhood of 42 wt %. The exact loading hasn't been determined at this time, and preliminary work is underway to determine this. I think that I should point out that we really feel that the licensing basis is already available for what we are calling near-term fuel. That basis exists because of the extensive data obtained in the development of fuel for the ATR and for the HFIR. Those two reactors plus a few others are already making use of fuels loaded to this density at, of course, 93% enrichment. We don't see any real need from a metallurgical point of view to go through the complete demonstrations again. What we are doing though is loading this fuel with an enrichment and density which will be applicable in many cases in the near term, as it was mentioned yesterday, putting it in the ORR, burning it up, and doing a reasonable amount of post-irradiation examination. This data, we think, will be useful in licensing. Dr. Kanda mentioned in a comment earlier today that through the joint study with our program the Japanese are wanting to gain certain information from these experiments. We think that the experiments can satisfy those requirements. We would also be very interested to hear from any of the rest of you, the users, those of you who have to be concerned about gaining these licensing approvals, what sorts of information might really be needed here for any near-term work. We're planning to irradiate at least some elements to the order of, I would say, 90% burnup. Now, as it turns out in these elements at this enrichment and density, 90% burnup doesn't even surpass the burnup levels that have already been demonstrated as acceptable in the 93%-enriched fuels, and, therefore, one doesn't expect to find any swelling problems or any metallurgical-type problems at all. We will go through certain postirradiation examinations, however, but unless we see the need from some of the early parts of the examinations, we don't plan extensive metallurgical examinations. For these experiments, we would encourage participation by any fuel vendor who is interested in providing a few elements. We are not talking about many, maybe the order of two or three per vendor, which could be used in this program and would then, at least, provide a look to the rest of the world at elements made by particular vendors to particular enrichments and irradiated to good burnups. The other parts of our program in the near-term have to do with whole core demonstrations, and the one that is really planned at this time is the Ford Nuclear Reactor at the University of Michigan. The primary purpose of this demonstration is to have a core in which we can investigate the physics and safety characteristics of 20%-enriched fuel and compare them with those of the 93%-enriched cores. We will also use the data for verification of our analytical methods, so that when these methods are applied in evaluating the potential of other reactors for use of reduced-enrichment fuel, one will have increased confidence in the methods. I point out, of course, that there have been other reactors run with 20%-enriched fuel. However, that fuel was used quite awhile ago, and it's difficult today to obtain the sort of data in which we are really interested. The measurements in the FNR are planned to look at detailed flux distributions in the core and reflectors and at the ends of beam ports. It is also planned to measure the typical sorts of reactor characteristics which are always necessary to show that you're meeting your technical specifications and safety requirements.. The Ford Nuclear Reactor is an NRC licensed facility, and, as such, the University of Michigan will have to obtain licensing approval from NRC. We're hoping for the full cooperation of NRC, and we've been basically told that that will be forthcoming. We certainly don't anticipate that there are any new safety issues involved. We say te basis is there, and it's up to us, in cooperation with the University of Michigan, to demonstrate to the NRC that this is true. Out of this work will then come some documents that will be very useful as reference documents for any further near-term conversions using this type of fuel. I conclude my remarks here, and I will be happy to answer any questions

  19. Position Statement in RFID S&P Panel: RFID and the Middleman

    Science.gov (United States)

    Anderson, Ross

    Existing bank-card payment systems, such as EMV, have two serious vulnerabilities: the user does not have a trustworthy interface, and the protocols are vulnerable in a number of ways to man-in-the-middle attacks. Moving to RFID payments may, on the one hand, let bank customers use their mobile phones to make payments, which will go a fair way towards fixing the interface problem; on the other hand, protocol vulnerabilities may become worse. By 2011 the NFC vendors hope there will be 500,000,000 NFC-enabled mobile phones in the world. If these devices can act as cards or terminals, can be programmed by their users, and can communicate with each other, then they will provide a platform for deploying all manner of protocol attacks. Designing the security protocols to mitigate such attacks may be difficult. First, it will include most of the hot topics of IT policy over the last ten years (from key escrow through DRM to platform trust and accessory control) as subproblems. Second, the incentives may lead the many players to try to dump the liability on each other, leading to overall system security that is equivalent to the weakest link rather than to sum-of-efforts and is thus suboptimal.

  20. Microclimate boxes for panel paintings

    DEFF Research Database (Denmark)

    Wadum, Jørgen

    The use of microclimate boxes to protect vulnerable panel paintings is, therefore, not a new phenomenon of the past two or three decades. Rather, it has been a concern for conservators and curators to protect these objects of art at home and in transit since the end of the nineteenth century. The...... increased number of travelling exhibitions in recent years has heightened the need to protect paintings during circulation (Thomson 1961; Mecklenburg 1991). The use and design of microclimate boxes have been evolving since 1892. These boxes may be divided into three broad groups: those using an active...

  1. Discussion panel for Pilot:3

    OpenAIRE

    Malik, Suhail; Beech, Amanda; Esche, Charles; Phillips, Andrea; Poole, Matthew; Sassen, Saskia

    2007-01-01

    As part of the preview for the third edition of PILOT: during the opening week of the Venice Biennale, we are pleased to announce that we will be hosting a panel discussion in collaboration with PoCA, the Political Currency of Art research group. The discussion will focus on the historical trajectory of the Venice Biennale and its changing role within the shifting socio-political context of the city, as well as looking to issues within the art world in general regarding the role o...

  2. Report on Multiphase Flow Panel

    Science.gov (United States)

    2003-01-01

    This paper presents viewgraphs on a multiphase flow panel. The topics include: 1) Discussion of Priorities; 2) Critical Issues Reduced Gravity Instabilities; 3) Severely Limiting Phase Separation; 4) Severely-Limiting Phase Change; 5) Enhancements; 6) Awareness Instabilities; 7) Awareness; 8) Methods of Resolution; 9) 2008 Space Flight; 10) 2003-2008 Ground-Based Microgravity Facilities; 11) 2003-2008 Other; 12) 2009-2015 Space Flight; 13) 2009-2015 Ground-Based Microgravity Facilities; 14) 2009-2015 Other; and 15) 2016.

  3. Theoretical design of lightning panel

    Science.gov (United States)

    Emetere, M. E.; Olawole, O. F.; Sanni, S. E.

    2016-02-01

    The light trapping device (LTD) was theoretically designed to suggests the best way of harvesting the energy derived from natural lightning. The Maxwell's equation was expanded using a virtual experimentation via a MATLAB environment. Several parameters like lightning flash and temperature distribution were consider to investigate the ability of the theoretical lightning panel to convert electricity efficiently. The results of the lighting strike angle on the surface of the LTD shows the maximum power expected per time. The results of the microscopic thermal distribution shows that if the LTD casing controls the transmission of the heat energy, then the thermal energy storage (TES) can be introduced to the lightning farm.

  4. Prognostic ability of a panel of immunohistochemistry markers – retailoring of an 'old solution'

    OpenAIRE

    Brennan, Donal J.; Gallagher, William M.

    2008-01-01

    An urgent requirement exists for new prognostic and predictive assays in breast cancer. Despite the development of high-throughput technologies such as DNA microarrays, it would now appear that immunohistochemistry (IHC) may play an increasingly important role in the clinical management of breast cancer. In this editorial, the authors discuss the potential prognostic ability of a panel of IHC markers, and question whether this well-established assay technology may in fact allow for improved p...

  5. Executive Summary to EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals.

    Science.gov (United States)

    Gore, A C; Chappell, V A; Fenton, S E; Flaws, J A; Nadal, A; Prins, G S; Toppari, J; Zoeller, R T

    2015-12-01

    This Executive Summary to the Endocrine Society's second Scientific Statement on environmental endocrine-disrupting chemicals (EDCs) provides a synthesis of the key points of the complete statement. The full Scientific Statement represents a comprehensive review of the literature on seven topics for which there is strong mechanistic, experimental, animal, and epidemiological evidence for endocrine disruption, namely: obesity and diabetes, female reproduction, male reproduction, hormone-sensitive cancers in females, prostate cancer, thyroid, and neurodevelopment and neuroendocrine systems. EDCs such as bisphenol A, phthalates, pesticides, persistent organic pollutants such as polychlorinated biphenyls, polybrominated diethyl ethers, and dioxins were emphasized because these chemicals had the greatest depth and breadth of available information. The Statement also included thorough coverage of studies of developmental exposures to EDCs, especially in the fetus and infant, because these are critical life stages during which perturbations of hormones can increase the probability of a disease or dysfunction later in life. A conclusion of the Statement is that publications over the past 5 years have led to a much fuller understanding of the endocrine principles by which EDCs act, including nonmonotonic dose-responses, low-dose effects, and developmental vulnerability. These findings will prove useful to researchers, physicians, and other healthcare providers in translating the science of endocrine disruption to improved public health. PMID:26414233

  6. Financial Statement Fraud Detection using Text Mining

    OpenAIRE

    Rajan Gupta; Nasib Singh Gill

    2013-01-01

    Data mining techniques have been used enormously by the researchers’ community in detecting financial statement fraud. Most of the research in this direction has used the numbers (quantitative information) i.e. financial ratios present in the financial statements for detecting fraud. There is very little or no research on the analysis of text such as auditor’s comments or notes present in published reports. In this study we propose a text mining approach for detecting financial statement frau...

  7. Control of Bank Consolidated Financial Statements Quality

    OpenAIRE

    Margarita S. Ambarchyan

    2013-01-01

    The author presents the multiple linear regression model of bank consolidated financial statements quality. The article considers six characteristics that can be used to estimate the level of bank consolidated financial statements quality. The multiple linear regression model was developed, using the results of point-based system of consolidated financial statements of thirty European bank and financial groups on the basis of the developed characteristics. The author offers to use the charact...

  8. Saskatchewan Energy Holdings Ltd. consolidated financial statements

    International Nuclear Information System (INIS)

    The consolidated financial statements of Saskatchewan Energy Holdings Ltd. (formerly Saskatchewan Energy Corporation) as of December 31, 1990, and the consolidated statements of earnings and retained earnings and changes in cash position for the year are presented. Data include an inventory of supplies, natural gas in storage, property, plant and equipment. Financial statements are also presented for the year ending December 31, 1989, with comparative figures for the seven months ending December 31, 1988

  9. Cancer Basics

    Science.gov (United States)

    ... Cancer? Breast Cancer Colon/Rectum Cancer Lung Cancer Prostate Cancer Skin Cancer Show All Cancer Types News and Features Cancer Glossary ACS Bookstore Cancer Information Cancer Basics Cancer Prevention & Detection Signs & Symptoms of Cancer Treatments & Side Effects ...

  10. Solar-Panel Dust Accumulation and Cleanings

    Science.gov (United States)

    2005-01-01

    Air-fall dust accumulates on the solar panels of NASA's Mars Exploration Rovers, reducing the amount of sunlight reaching the solar arrays. Pre-launch models predicted steady dust accumulation. However, the rovers have been blessed with occasional wind events that clear significant amounts of dust from the solar panels. This graph shows the effects of those panel-cleaning events on the amount of electricity generated by Spirit's solar panels. The horizontal scale is the number of Martian days (sols) after Spirit's Jan. 4, 2005, (Universal Time) landing on Mars. The vertical scale indicates output from the rover's solar panels as a fraction of the amount produced when the clean panels first opened. Note that the gradual declines are interrupted by occasional sharp increases, such as a dust-cleaning event on sol 420.

  11. Financial Statement Fraud Detection using Text Mining

    Directory of Open Access Journals (Sweden)

    Rajan Gupta

    2013-01-01

    Full Text Available Data mining techniques have been used enormously by the researchers’ community in detecting financial statement fraud. Most of the research in this direction has used the numbers (quantitative information i.e. financial ratios present in the financial statements for detecting fraud. There is very little or no research on the analysis of text such as auditor’s comments or notes present in published reports. In this study we propose a text mining approach for detecting financial statement fraud by analyzing the hidden clues in the qualitative information (text present in financial statements.

  12. Acoustical behavior of hybrid composite sandwich panels

    OpenAIRE

    Patinha, Sérgio; Cunha, Fernando Eduardo Macedo; Fangueiro, Raúl; Rana, Sohel; Prego, Fernando

    2015-01-01

    This paper deals with the characterization of acoustic insulation behaviour of hybrid sandwich composite panels for application in modular house construction. These sandwich panels are a sustainable, light-weight and durable solution, since are based on natural fibers structure impregnated with a thermosetting polymer. In this way, three different types of hybrid composite panels containing polyurethane core and laminated composite skins were produced and analyzed, varying the ...

  13. Geothermal Technologies Program Blue Ribbon Panel Recommendations

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2011-06-17

    The Geothermal Technologies Program assembled a geothermal Blue Ribbon Panel on March 22-23, 2011 in Albuquerque, New Mexico for a guided discussion on the future of geothermal energy in the United States and the role of the DOE Program. The Geothermal Blue Ribbon Panel Report captures the discussions and recommendations of the experts. An addendum is available here: http://www.eere.energy.gov/geothermal/pdfs/gtp_blue_ribbon_panel_report_addendum10-2011.pdf

  14. New statement of leave format

    CERN Multimedia

    HR Department

    2009-01-01

    Following the communication of the Standing Concertation Committee published in Weekly Bulletin No. 18-19 of 27 April 2009, the current statement of leave on monthly pay slips has been replaced with the EDH Leave Transactions report that displays the up-to-date situation of individual leave balances at all times. The report is available on EDH. Additionally, the layout of the pay slip has been modernised. The new version of the pay slip will be send out from September 2009 onwards. Finance and Purchasing Department, Personnel Accounting Human Resources Department, Organisation and Procedures General Infrastructure Services Department, Administrative Information Services

  15. Position Statement On Climate Change.

    Science.gov (United States)

    2016-05-01

    The North Carolina Environmental Justice Network (NCEJN), a coalition of grassroots organizations, developed a statement to explain our environmental justice perspective on climate change to predominantly white environmental groups that seek to partner with us. NCEJN opposes strategies that reduce greenhouse emissions while maintaining or magnifying existing social, economic, and environmental injustices. Wealthy communities that consume a disproportionate share of resources avoid the most severe consequences of their consumption by displacing pollution on communities of color and low income. Therefore, the success of climate change activism depends on building an inclusive movement based on principles of racial, social and economic justice, and self-determination for all people. PMID:26920851

  16. Statement

    International Nuclear Information System (INIS)

    Idaho National Engineering and Environmental Laboratory (INEEL), established more than 50 years ago, INEEL's had a historical mission to support development of many designs, systems, codes and safety features for nuclear power facilities around the world. It has also been a disposal site for radioactive and hazardous wastes, particularly those wastes associated with the US nuclear weapons programmes and the United States Navy's nuclear ships. There are many public concerns when a nuclear facility closure is announced.The point that I would like to make today is that such an announcement should not come as unexpected news to the local communities. Facility closure could result in facility reuse or complete dismantlement. If a facility is to be dismantled, environmental contamination must be addressed to reduce risks to humans and the environment. If it is possible to reduce contamination to acceptable levels, a wide range of land uses may be possible. If not, provisions for long term stewardship must be made. Changes in employment and funding levels, whether for a commercial power plant or a government programme. Communities need to plan for social and economic impacts that will occur. Future land use plans, with provision for local involvement in the selection of cleanup remedies and a clear understanding of environmental restrictions on land that may be released from ownership of the controlling entity. Funding for adequate closure activities, for long term monitoring, and for necessary actions in the future needs to be ensured. Security arrangements need to be anticipated and agreed upon with local entities.This is particularly important because local governments are frequently the 'first responders' to incidents on or near the facility during its operational phases; that role will continue or be expanded upon post-closure

  17. Statement

    International Nuclear Information System (INIS)

    Full text: In Canada, we have not yet decommissioned a nuclear power plant, although there are some prototypes in safe store. However, we have decommissioned a commercial isotope production facility and a small research reactor facility, and the sites were ultimately released from regulatory control. We are currently involved in regulating the decommissioning of Atomic Energy of Canada's research facility at Whiteshell in Manitoba and various small infrastructure programmes at the Chalk River National Laboratories. For these type of projects, IAEA guidance forms the basis for our regulatory decisions. Clearance of materials is based on IAEA guidance criteria. These criteria are used for material contaminated with artificial radiation or with technologically enhanced naturally occurring radioactive material. We have not established clearance criteria for material bound for recycle or reuse for the simple reason that the industries that would receive such material have taken a 'zero tolerance' stance. Scrap steel recyclers are loath to take material with any level of contamination in case it cannot be passed on. The main decommissioning or remediation experience in Canada is with historical uranium mines and their associated tailings, and with contaminated lands associated with the historical use of radium and uranium.These are really intervention activities. While Canadian nuclear regulation does not contain explicit criteria for the release of buildings or sites from regulatory control, our current regulatory scheme does specify that the regulator may order the cleanup of unlicensed sites that could give rise to doses greater than 1 mSv/a We have therefore taken that criterion of a potential dose of 1 mSv/a to be the upper bound for cleanup for historically contaminated sites and then apply as low as reasonably achievable (ALARA) considerations to establish site specific clearance levels. Since many of these sites are in rural areas with a very low population density and varying traditional uses, we take site specific approaches to assessing potential doses. For example, as well as establishing maximum acceptable gamma dose rates, we acquire information on local hunting, fishing and product gathering practices and estimates of the typical times that could be spent on the land in question. As you can imagine, this requires extensive consultation with the local population.We believe this approach is a good one as it helps build confidence in the local population that their situation is understood, and is particularly important when we are dealing with communities which still obtain a significant portion of their diet directly from the local area. In some situations, sites have been released completely from regulatory control. In other situations, regulatory controls could be reduced to requirements for posting of warning signs, public education programmes and filing of information on recommended restrictions with the local government land registry. In summary, Canada is taking a site by site approach to decommissioning and remediation projects using criteria consistent with international guidance. (author)

  18. Statement

    International Nuclear Information System (INIS)

    It is generally up to the operator to propose to the regulator some dismantling strategy. The regulator hence has to judge if these strategies are safe and sustainable. Regulators often propose strategies that involve large waiting periods before dismantling. Their arguments are based on: Favourable effect of radioactive decay; Possibility of benefiting from new dismantling technologies; Benefits of waiting from a financial point of view. For all these reasons, the regulator should promote in most cases immediate dismantling. The main reason for deferred dismantling would be if large amounts of waste cannot be eliminated and would be kept safer within the facility. Entombment is definitely not a sustainable option as it requires, as for long term storage, permanent surveillance and maintenance. If a waste elimination pathway (such as a disposal facility) does not exist for certain categories of waste, a choice has to be made by the operator between: Proposing deferred dismantling because the waste is considered safer if it is enclosed in the facility; and developing and building a specific waste storage facility. Recent experience involving the nuclear industry as well as the conventional industry has shown the necessity to keep track of past uses of land and to at least define the minimum use restrictions when a facility handling hazardous materials has been occupying the site. Contaminated soil can be left in place, provided that optimization has been done and that it is not justified to intervene on a cost/effect basis. This topic has of course to be dealt with in an open discussion organized with stakeholders. An impact study has to be provided and land use restrictions have to be put in place and, as a precaution, possibly continuous monitoring of the funded site

  19. Statement

    International Nuclear Information System (INIS)

    Full text: The question of clearance of materials, buildings and sites from regulatory control is one of the most controversial and discussed questions, if not the most, at all conferences, workshops and working groups dealing with decommissioning. In fact, the aspects of clearance, recycling and reuse have a major influence on global decommissioning costs. Furthermore, these questions involve different stakeholders: on the one hand the owner and operator of the plant, on the other hand the general public and, between both, the regulator. Finally, the recent evolution of the regulations related to the use within the non-nuclear industry of materials containing natural radioactivity and to the cleanup of contaminated sites from post activities leads necessarily to the comparison of criteria to be handled in both industries. What are the differences between these industries? One difference is certainly the public relationship to those industries, and thus the public perception of the risk from the material handled in both industries. On the one hand, it is fissile material, which must be dangerous; on the other hand it is fertilizer, which nearly everybody spreads over his or her land.That cannot be dangerous, it is accepted because it is part of normal life such as driving a car, and the risk is considered normal. But one more becquerel in a car arising from cleared steel from the nuclear industry is not normal, and thus not accepted. The nuclear industry is thus faced with a public perception leading to a public acceptance of zero additional doses from that industry, while a non-negligible additional dose from medicine and normal life such as flying are accepted. Another difference is certainly the type of material contaminated with radionuclides and the type of radioactivity. On the one hand, we have mainly metals and concrete contaminated or activated. And there is even a difference between contaminated and activated structures. In fact, existing decontamination techniques make it more or less easy to decontaminate most structures with only surface contamination, whatever are the clearance limits; it is possible to recover the basic material behind the removable contaminated layer. In the case of activated shielding structures, however, the thickness of the layer considered as radioactive depends greatly on the clearance criteria. On the other hand, stakeholders have to deal with enormous amounts of slightly contaminated raw material or process residues, mostly with isotopes from the U and Th families. I would like to finish this introduction with a few observations from a remediation project of a storage area where Ra contaminated residues and debris from a former non-licensed Ra production facility are stored. The authorities in my country are now dealing with this remediation programme. The disposed amount of contaminated material is in the range of 220 000 m3, between three and four times the amount of low level waste arising from all the licensed practices in the country since the beginning of nuclear activities and including future waste from the decommissioning of existing plants.The activity concentration of the Ra storage area is of the order of 10 000 Bq/g at some places, but the average concentration is somewhere between 10 and probably 100 Bq/g. Should we now treat this material in the same way as contaminated material from controlled areas? Or should we manage the waste from decommissioning as we will manage that from this Ra contaminated storage? Or should we use different strategies? These are some of the questions for discussion. (author)

  20. Statement

    International Nuclear Information System (INIS)

    This presentation deals summarizes the results of a recent National Research Council report on establishing clearance standards for the release of radioactively contaminated materials. The National Research Council report, deal with the Disposition Dilemma: Controlling the Release of Solid Materials from Nuclear Regulatory Commission-Licensed Facilities, was undertaken at the request of the US Nuclear Regulatory Commission (NRC) to help inform its deliberations on the development of a new standard. The Research Council was asked to provide advice on the following issues: The sufficiency of the technical bases needed to establish a standard; How to incorporate the concerns of stakeholders in the standard setting process; Changes, if any, that should be made to the NRC's current clearance system. Accordingly, the report recommends that the NRC: Proceed forthwith to evaluate alternatives to the current system; Involve stakeholders in a broad based evaluation process of alternative approaches; Adopt a dose based standard as the primary standard and consider the establishment of a separate collective dose standard; 10 mSv per year as a starting point in establishing a dose based standard; Continue to review, assess and participate in ongoing international efforts to manage the disposition of slightly contaminated materials. In conclusion it is stated that the experience in the USA suggests that the establishment of a clearance standard is likely to be a long and painful process. It is suggested that the NRC and the international community give careful consideration to the use of risk based approaches as they evaluate alternatives for establishing these standards

  1. Statement

    International Nuclear Information System (INIS)

    Full text: 1. A clearance system based on universal clearance levels is not sustainable. Universal criteria based on radioactivity limits for the removal of control will lead to problems with the public if unexpected or unaccounted for uses lead to significant exposures, or exposures that are not justified. Universal clearance levels are usually based on the hypothesis of waste dilution in recycling processes (such as for steel). It is prone to criticism and will have to be reevaluated, in particular if extended dismantling programmes are carried out in a country or through unique steel recycling companies, leading to changing clearance levels. Moreover, in some cases, industrial processes can lead to radionuclide concentration in some materials, like slag, that can lead to disposal or recycling problems. Social demands can lead to changes in the impact levels accepted in the future, leading to difficulties. In France, a system has been implemented that is not based on clearance levels for release in the public domain. Provided that it is implemented on a coherent, nationwide basis, this system does not lead to an excessive burden for the industry, and has led to a wide social acceptance of the system. 2. Clearance on a case by case basis is feasible On the other hand, it is possible to clear material on a case by case basis, provided that the clearance pathway of the material is well defined, and an impact study is provided. The clearance pathway has to be authorized after an open discussion has taken place between involved stakeholders, including representatives of the public and of antinuclear associations. A follow-up system has to be provided to be able to identify items involving cleared materials, should concern arise afterwards. If the material is recycled, clearance impact criteria do not have to be taken into account, and the impact study has to be made on a case by case basis. 3. Segregation between 'conventional' and 'radioactive' waste is achievable The objective is to achieve a segregation between 'nuclear waste' (waste susceptible to be or to have been contaminated by radionuclides or activated) and 'conventional waste' (waste that is not susceptible to be or to have been contaminated nor activated). Note that this distinction is made without using any screening level to distinguish between 'nuclear' and 'conventional' waste categories.The definition of 'nuclear waste' is quite wide and clearly contains a measure of precaution. This segregation between nuclear and conventional waste has to be made without any measurement basis in order to provide a valid additional line of defence in the whole system; hence other arguments are needed to make this distinction. These arguments are: An analysis of the functions achieved by the materials within the facility, which determines if they can ever be contaminated or activated; An analysis of the past operating history of the facility, including incidents and accidents, in order to determine whether this material has served another purpose or could have been contaminated during an incident or an accident, which are situations in which the facility is operated beyond its normal operating boundaries. It can be seen that these arguments are strongly linked to the physical position of the object or material in the facility; hence the distinction between 'nuclear' and 'conventional' waste can be made on a geographical basis. A corresponding facility waste zoning can be implemented. Linked with appropriate radioactivity measurements, that increase confidence that conventional waste is indeed conventional, this system can provide a high level of confidence in this segregation. This system has been implemented successfully in France, and has been shown to not put an unbearable burden on the operators, provided that it is included in a nationwide, coherent policy, including available and cost efficient waste elimination options (e.g. repositories) for very low level waste. (author)

  2. Statement

    International Nuclear Information System (INIS)

    Full text: I am glad to be here for this presentation this morning. As you know, the Republic of Korea has had much experience in the construction and operation of nuclear power plants (NPPs), but we have no experience in decommissioning. The first research reactor in the Republic of Korea, KRR-1 TRIGA Mark II, first started operation in 1962, and the second one, KRR-2 TRIGA Mark III, first started in 1972. Operation of both of these was phased out in 1995 when they reached the end of their life span and also due to the operation of a new research reactor, HANARO (High-flux Advanced Neutron Application Reactor), at the site of the Korea Atomic Energy Research Institute (KAERI) in Taejon. The decommissioning project for both research reactors was launched in January 1997 and will be completed in December 2008. KAERI has to choose the immediate decommissioning approach because of the following reasons. First, the land and reactor buildings were sold to the Korea Electric Power Co. (KEPCO) in 1985. By the terms of the Atomic Energy Act, KAERI as the operator must decommission the reactor. Second, research and development related to decommissioning should be carried out for secure NPP decommissioning that is upcoming. Lastly, KAERI must prevent the spread of radiation hazards into the reactor building's environs, which is rapidly becoming a densely populated area because of urbanization. Most of the radioactive wastes produced during decommissioning will be packed in 4 m3 ISO type containers, which will then be stored until they are transported to the national disposal site for low and intermediate level waste. Even though it is not certain when the disposal site will be operational, decommissioning should not be deferred. Both of the reactors and related facilities are not in good condition because of minimum budgeting for the maintenance of the facilities. The most important issue is how to keep radioactive materials in a safe and well controlled condition. Therefore, KAERI decided upon immediate decommissioning of both research reactors. Currently, the Republic of Korea has 17 NPPs in operation.They consist of 13 PWR and 4 CANDU type PHWR reactors.The first NPP in the Republic of Korea was Kori-1, which started operation in 1978. Taking into account its design life span of 30 years, it will be shut down in 2008. But the utility company for the NPP, the Korea Hydro-Nuclear Co. (KHNC), is promoting the extension of its life. However, it is expected that there will be many difficulties in obtaining public acceptance. In considering the decommissioning of the NPP, it is recommended that heavily populated countries such as the Republic of Korea choose immediate decommissioning. According to the power supply plan of Korea, 11 more NPPs are being planned for construction and operation until the year 2015. However, it is not easy to get new sites for them. Therefore, it is desirable to locate the new reactors at current sites. Most of the sites have duplicate reactors, but their life spans are not comparable with each other. Therefore, decommissioning should wait until both reactors at the site have reached the end of their life. After decommissioning of the retired reactor, it is desirable to install the Korean Standard Nuclear Plant (KSNP), which has a capacity of 1400 MW(e). This will be one way of resolving the siting problem and reducing the cost of decommissioning and construction. If the Republic of Korea decides to start decommissioning NPPs in 2013, it is necessary to secure the necessary and related technologies for successful decommissioning through R and D. Therefore, during the decommissioning of KRR-1 and KRR-2, basic technologies will be developed and demonstrated under middle to long term R and D programmes. The object of the first stage of the programme, from August 2001 to March 2004, is technology development related to the decommissioning of the research reactor. During the second stage of the programme, April 2004 to March 2007, the basic techniques will be developed for the decommissioning of NPPs.Thank you for your attention. (author)

  3. 20 CFR 335.3 - Execution of statement of sickness and supplemental doctor's statement.

    Science.gov (United States)

    2010-04-01

    ...-abuse professional as defined in 49 CFR part 40.3, if the infirmity involves alcohol or controlled... supplemental doctor's statement. 335.3 Section 335.3 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS... sickness and supplemental doctor's statement. (a) Who may execute. A statement of sickness and any...

  4. Panel data specifications in nonparametric kernel regression

    DEFF Research Database (Denmark)

    Czekaj, Tomasz Gerard; Henningsen, Arne

    We discuss nonparametric regression models for panel data. A fully nonparametric panel data specification that uses the time variable and the individual identifier as additional (categorical) explanatory variables is considered to be the most suitable. We use this estimator and conventional...... parametric panel data estimators to analyse the production technology of Polish crop farms. The results of our nonparametric kernel regressions generally differ from the estimates of the parametric models but they only slightly depend on the choice of the kernel functions. Based on economic reasoning, we...... found the estimates of the fully nonparametric panel data model to be more reliable....

  5. Interagency Security Classification Appeals Panel (ISCAP) Decisions

    Data.gov (United States)

    National Archives and Records Administration — This online collection includes documents decided upon by the Interagency Security Classification Appeals Panel (ISCAP) starting in Fiscal Year 2012. The documents...

  6. Personality Has Minor Effects on Panel Attrition

    OpenAIRE

    Richter, David; Körtner, John L.; Saßenroth, Denise

    2014-01-01

    Abstract In light of the recent interest in using longitudinal panel data to study personality development, it is important to know if personality traits are related to panel attrition. We analyse the effects of personality on panel drop-out separately for an ‘older’ subsample (started in 1984), a relatively ‘young’ subsample (started in 2000), and a ‘new’ subsample (started in 2009) of the German Socio-Economic Panel (SOEP) study. We found that openness slightly decreases the probability of ...

  7. Development of Electrostatically Clean Solar Array Panels

    Science.gov (United States)

    Stern, Theodore G.

    2000-01-01

    Certain missions require Electrostatically Clean Solar Array (ECSA) panels to establish a favorable environment for the operation of sensitive scientific instruments. The objective of this program was to demonstrate the feasibility of an ECSA panel that minimizes panel surface potential below 100mV in LEO and GEO charged particle environments, prevents exposure of solar cell voltage and panel insulating surfaces to the ambient environment, and provides an equipotential, grounded structure surrounding the entire panel. An ECSA panel design was developed that uses a Front Side Aperture-Shield (FSA) that covers all inter-cell areas with a single graphite composite laminate, composite edge clips for connecting the FSA to the panel substrate, and built-in tabs that interconnect the FSA to conductive coated coverglasses using a conductive adhesive. Analysis indicated the ability of the design to meet the ECSA requirements. Qualification coupons and a 0.5m x 0.5m prototype panel were fabricated and tested for photovoltaic performance and electrical grounding before and after exposure to acoustic and thermal cycling environments. The results show the feasibility of achieving electrostatic cleanliness with a small penalty in mass, photovoltaic performance and cost, with a design is structurally robust and compatible with a wide range of current solar panel technologies.

  8. Uncertainties in predicting solar panel power output

    Science.gov (United States)

    Anspaugh, B.

    1974-01-01

    The problem of calculating solar panel power output at launch and during a space mission is considered. The major sources of uncertainty and error in predicting the post launch electrical performance of the panel are considered. A general discussion of error analysis is given. Examples of uncertainty calculations are included. A general method of calculating the effect on the panel of various degrading environments is presented, with references supplied for specific methods. A technique for sizing a solar panel for a required mission power profile is developed.

  9. Immunotargeting of cancer stem cells

    OpenAIRE

    Kwiatkowska-Borowczyk, Eliza P.; Gąbka-Buszek, Agnieszka; Jankowski, Jakub; Mackiewicz, Andrzej

    2015-01-01

    Cancer stem cells (CSCs) represent a distinctive population of tumour cells that control tumour initiation, progression, and maintenance. Their influence is great enough to risk the statement that successful therapeutic strategy must target CSCs in order to eradicate the disease. Because cancer stem cells are highly resistant to chemo- and radiotherapy, new tools to fight against cancer have to be developed. Expression of antigens such as ALDH, CD44, EpCAM, or CD133, which distinguish CSCs fr...

  10. ERS statement on the multidisciplinary respiratory management of ataxia telangiectasia.

    Science.gov (United States)

    Bhatt, Jayesh M; Bush, Andrew; van Gerven, Marjo; Nissenkorn, Andreea; Renke, Michael; Yarlett, Lian; Taylor, Malcolm; Tonia, Thomy; Warris, Adilia; Zielen, Stefan; Zinna, Shairbanu; Merkus, Peter J F M

    2015-12-01

    Ataxia telangiectasia (A-T) is a rare, progressive, multisystem disease that has a large number of complex and diverse manifestations which vary with age. Patients with A-T die prematurely with the leading causes of death being respiratory diseases and cancer. Respiratory manifestations include immune dysfunction leading to recurrent upper and lower respiratory infections; aspiration resulting from dysfunctional swallowing due to neurodegenerative deficits; inefficient cough; and interstitial lung disease/pulmonary fibrosis. Malnutrition is a significant comorbidity. The increased radiosensitivity and increased risk of cancer should be borne in mind when requesting radiological investigations. Aggressive proactive monitoring and treatment of these various aspects of lung disease under multidisciplinary expertise in the experience of national multidisciplinary clinics internationally forms the basis of this statement on the management of lung disease in A-T. Neurological management is outwith the scope of this document. PMID:26621971

  11. ERS statement on the multidisciplinary respiratory management of ataxia telangiectasia

    Directory of Open Access Journals (Sweden)

    Jayesh M. Bhatt

    2015-12-01

    Full Text Available Ataxia telangiectasia (A-T is a rare, progressive, multisystem disease that has a large number of complex and diverse manifestations which vary with age. Patients with A-T die prematurely with the leading causes of death being respiratory diseases and cancer. Respiratory manifestations include immune dysfunction leading to recurrent upper and lower respiratory infections; aspiration resulting from dysfunctional swallowing due to neurodegenerative deficits; inefficient cough; and interstitial lung disease/pulmonary fibrosis. Malnutrition is a significant comorbidity. The increased radiosensitivity and increased risk of cancer should be borne in mind when requesting radiological investigations. Aggressive proactive monitoring and treatment of these various aspects of lung disease under multidisciplinary expertise in the experience of national multidisciplinary clinics internationally forms the basis of this statement on the management of lung disease in A-T. Neurological management is outwith the scope of this document.

  12. Statement on the safety of ?-carotene use in heavy smokers

    OpenAIRE

    EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)

    2012-01-01

    Following a request by the European Commission the Scientific Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to conclude on the possible link between the ingestion of β-carotene and cancer enhancement in heavy smokers. The safety of (synthetic) β-carotene [E 160a (ii)] has been evaluated previously by JECFA (1975) and by the SCF (2000a).  In 2000, the SCF concluded that there were insufficient data to set a precise figure for a Tolerable Upper Intake Level (UL) of ...

  13. USING AREAS AND ENSURING ADVANTAGES OF PLYWOOD PANELS S OF PLYWOOD PANELS

    OpenAIRE

    Demirkır, Cenk

    2011-01-01

    Plywood which is a wood based panel has many usage areas. Usage areas of plywood panels have changed among countries according to economic, sociocultural and tradition of countries. The plywood panels that are especially used as ground, wall and roof covering have supplied important advantages to building. The most important advantage is being more resistance of buildings which are covered the plywood panels to lateral forces such as earthquake and wind. It was determined that the dead rates ...

  14. Analytical and Clinical Validation of a Digital Sequencing Panel for Quantitative, Highly Accurate Evaluation of Cell-Free Circulating Tumor DNA

    OpenAIRE

    Lanman, Richard B.; Mortimer, Stefanie A.; Zill, Oliver A.; Sebisanovic, Dragan; Lopez, Rene; Blau, Sibel; Collisson, Eric A.; Divers, Stephen G.; Hoon, Dave S.B.; Kopetz, E. Scott; Lee, Jeeyun; Nikolinakos, Petros G.; Baca, Arthur M.; Kermani, Bahram G.; Eltoukhy, Helmy

    2015-01-01

    Next-generation sequencing of cell-free circulating solid tumor DNA addresses two challenges in contemporary cancer care. First this method of massively parallel and deep sequencing enables assessment of a comprehensive panel of genomic targets from a single sample, and second, it obviates the need for repeat invasive tissue biopsies. Digital SequencingTM is a novel method for high-quality sequencing of circulating tumor DNA simultaneously across a comprehensive panel of over 50 cancer-relate...

  15. Should Male Circumcision be Advocated for Genital Cancer Prevention?

    OpenAIRE

    Morris, Brian J.; Mindel, Adrian; Tobian, Aaron AR; Hankins, Catherine A.; Ronald H Gray; Bailey, Robert C.; Bosch, Xavier; Wodak, Alex D

    2012-01-01

    The recent policy statement by the Cancer Council of Australia on infant circumcision and cancer prevention and the announcement that the quadrivalent human papillomavirus (HPV) vaccine will be made available for boys in Australia prompted us to provide an assessment of genital cancer prevention. While HPV vaccination of boys should help reduce anal cancer in homosexual men and cervical cancer in women, it will have little or no impact on penile or prostate cancer. Male circumcision can reduc...

  16. A Novel Satellite Concept “Panel Extension Satellite (PETSAT)” Consisting of Plug-in, Modular, Functional Panels

    OpenAIRE

    Nakasuka, Shinichi; Sahara, Hironori; Sugawara, Yoshiki; Morimoto, Takeshi; Koyama, Kanichi; Kikuchi, Hideaki; Okada, Takanori; Tanaka, Hidenori; Sato, Shinichi; Kobayashi, Chisato

    2007-01-01

    A novel concept of satellite design, named "PETSAT," is proposed in this paper. In this concept, a satellite is made of several "Functional Panels" such as "Communication panel," "Attitude control panel," "Thruster panel," and “Mission Panel,” each of which has a special dedicated function. By connecting these panels by reliable connection mechanism in "plug-in" fashion, the total integrated system as a whole has a satellite function. Various combinations of functional panels, (for example, o...

  17. North Central Transmission Line Project: Report of the Federal/Provincial Environmental Assessment Panel

    International Nuclear Information System (INIS)

    Manitoba Hydro has proposed constructing ca 520 km of power transmission and distribution lines from the Kelsey Station on the Nelson River to seven remote native communities in the northern part of the province. The purpose of the project is to provide those communities, currently served by local diesel-powered generating plants, with unrestricted electrical supply. A joint federal-provincial review of the project was undertaken to meet the requirements of both governments regarding an assessment of the project's environmental effects. A panel was established which consulted with community leaders and other interested parties, examined the proposed route, and visited the project communities. The panel viewed the project in the broader context of northern development and the principles of sustainable development were applied in the assessment process. Guidelines were then issued for Manitoba Hydro; these guidelines formed the basis for the formal environmental impact statement prepared by the utility. Public hearings were held in Thompson and the seven communities to consider issues related to the environmental impact statement, including the need for the project, the routing of the transmission line, the projected impacts, and mitigative measures related to those impacts. The panel concluded that the proposed project is necessary given the inadequacy of the currently used power system and projected power demand, that the route selection process was satisfactory, and that the project can be completed in a manner that negative impacts on the environment, culture, and people are mitigable. The panel therefore recommended that the project proceed, and made recommendations setting out specific terms and conditions. 23 refs., 5 figs

  18. Lepreau 2 environmental impact statement

    International Nuclear Information System (INIS)

    Maritime Nuclear, a joint undertaking of Atomic Energy of Canada Limited and the New Brunswick Electric Power Commission, proposes to construct a second CANDU 600 MW nuclear-powered generating unit at the site of the existing Point Lepreau Generating Station, in New Brunswick. A feasibility study is now underway and guidelines issued by the Lepreau 2 Environmental Assessment Panel identified six priority issues and concerns. These are: impacts on the biological environment, impacts of radiation on humans, impacts on the socio-economic environment, monitoring, emergency planning, and decommissioning. These factors as well as a description of the site and proposed facility are described in this report

  19. The Neutron Monitor Control Panel

    Science.gov (United States)

    García-Población, O.; Ivanov, H.; García-Tejedor, I.; Blanco, J. J.; Medina, J.; Gómez-Herrero, R.; Catalán, E.; Radchenko, D.

    2015-08-01

    This work presents the current status and future plans of the Neutron Monitor Control Panel (NMCP), a new software developed to aid the operator in typical station maintenance and configuration operations. This software is integrated with the new so-called NOAS data acquisition system and it can be accessed using a supported web browser. It features a visual inspection tool to help the operator to identify spikes in the data, trace the origin of the spike back to the raw readings of each counter tube and pressure reading, and mark the data as invalid in the Neutron Monitor Database if desired. The software also provides information about station operation status, some descriptive statistics about current data being recorded and, in the future, will provide an interface to configure station parameters.

  20. 45 CFR 1636.3 - Access to written statements.

    Science.gov (United States)

    2010-10-01

    ... CLIENT IDENTITY AND STATEMENT OF FACTS § 1636.3 Access to written statements. (a) Written statements of... party other than those listed in paragraph (a) of this section any right of access to the...

  1. 77 FR 52721 - Appraisal Subcommittee; Proposed Policy Statements

    Science.gov (United States)

    2012-08-30

    ... defined in the proposed Policy Statement) to the ASC via the extranet application for inclusion on the... INSTITUTIONS EXAMINATION COUNCIL Appraisal Subcommittee; Proposed Policy Statements AGENCY: Appraisal Subcommittee of the Federal Financial Institutions Examination Council ACTION: Proposed policy statements...

  2. 48 CFR 222.406-6 - Payrolls and statements.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Payrolls and statements... Labor Standards for Contracts Involving Construction 222.406-6 Payrolls and statements. (a) Submission..., Statement of Compliance, with each payroll report....

  3. AQUEOUS HOMOGENEOUS REACTORTECHNICAL PANEL REPORT

    Energy Technology Data Exchange (ETDEWEB)

    Diamond, D.J.; Bajorek, S.; Bakel, A.; Flanagan, G.; Mubayi, V.; Skarda, R.; Staudenmeier, J.; Taiwo, T.; Tonoike, K.; Tripp, C.; Wei, T.; Yarsky, P.

    2010-12-03

    Considerable interest has been expressed for developing a stable U.S. production capacity for medical isotopes and particularly for molybdenum- 99 (99Mo). This is motivated by recent re-ductions in production and supply worldwide. Consistent with U.S. nonproliferation objectives, any new production capability should not use highly enriched uranium fuel or targets. Conse-quently, Aqueous Homogeneous Reactors (AHRs) are under consideration for potential 99Mo production using low-enriched uranium. Although the Nuclear Regulatory Commission (NRC) has guidance to facilitate the licensing process for non-power reactors, that guidance is focused on reactors with fixed, solid fuel and hence, not applicable to an AHR. A panel was convened to study the technical issues associated with normal operation and potential transients and accidents of an AHR that might be designed for isotope production. The panel has produced the requisite AHR licensing guidance for three chapters that exist now for non-power reactor licensing: Reac-tor Description, Reactor Coolant Systems, and Accident Analysis. The guidance is in two parts for each chapter: 1) standard format and content a licensee would use and 2) the standard review plan the NRC staff would use. This guidance takes into account the unique features of an AHR such as the fuel being in solution; the fission product barriers being the vessel and attached systems; the production and release of radiolytic and fission product gases and their impact on operations and their control by a gas management system; and the movement of fuel into and out of the reactor vessel.

  4. Position Statement on Active Outdoor Play

    Directory of Open Access Journals (Sweden)

    Mark S. Tremblay

    2015-06-01

    Full Text Available A diverse, cross-sectorial group of partners, stakeholders and researchers, collaborated to develop an evidence-informed Position Statement on active outdoor play for children aged 3–12 years. The Position Statement was created in response to practitioner, academic, legal, insurance and public debate, dialogue and disagreement on the relative benefits and harms of active (including risky outdoor play. The Position Statement development process was informed by two systematic reviews, a critical appraisal of the current literature and existing position statements, engagement of research experts (N = 9 and cross-sectorial individuals/organizations (N = 17, and an extensive stakeholder consultation process (N = 1908. More than 95% of the stakeholders consulted strongly agreed or somewhat agreed with the Position Statement; 14/17 participating individuals/organizations endorsed it; and over 1000 additional individuals and organizations requested their name be listed as a supporter. The final Position Statement on Active Outdoor Play states: “Access to active play in nature and outdoors—with its risks— is essential for healthy child development. We recommend increasing children’s opportunities for self-directed play outdoors in all settings—at home, at school, in child care, the community and nature.” The full Position Statement provides context for the statement, evidence supporting it, and a series of recommendations to increase active outdoor play opportunities to promote healthy child development.

  5. The 7 Aarhus Statements on Climate Change

    DEFF Research Database (Denmark)

    Basse, Ellen Margrethe; Svenning, Jens-Christian; Olesen, Jørgen E; Besenbacher, Flemming; Læssøe, Jeppe; Seidenkrantz, Marit-Solveig; Lange, Lene

    2009-01-01

    statements were also communicated to the Danish Government as well as to the press. This article is the product of the collective subsequent work of the seven theme responsibles and is a presentation of each theme statement in detail, emphasizing the current state of knowledge and how it may be used to...

  6. 78 FR 31924 - Appraisal Subcommittee; Policy Statements

    Science.gov (United States)

    2013-05-28

    ... Statements on the date set forth below. \\1\\ 77 FR 52721 (Aug. 30, 2012). \\2\\ The 50 States, the District of... education, experience requirements, and examination. Three of the five Commenters addressing this proposed... INSTITUTIONS EXAMINATION COUNCIL Appraisal Subcommittee; Policy Statements AGENCY: Appraisal Subcommittee...

  7. 27 CFR 5.63 - Mandatory statements.

    Science.gov (United States)

    2010-04-01

    ....” (2) Optional statement. In addition, the advertisement may also state the alcohol content in degrees... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Mandatory statements. 5.63 Section 5.63 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU,...

  8. 27 CFR 7.52 - Mandatory statements.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Mandatory statements. 7.52 Section 7.52 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT....52 Mandatory statements. (a) Responsible advertiser. The advertisement shall state the name...

  9. 27 CFR 4.62 - Mandatory statements.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Mandatory statements. 4.62 Section 4.62 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... statements. (a) Responsible advertiser. The advertisement shall state the name and address of the...

  10. 7 CFR 4279.137 - Financial statements.

    Science.gov (United States)

    2010-01-01

    ... accordance with Generally Accepted Accounting Principles will be required. (b) If specific circumstances... 7 Agriculture 15 2010-01-01 2010-01-01 false Financial statements. 4279.137 Section 4279.137... § 4279.137 Financial statements. (a) The lender will determine the type and frequency of submission...

  11. 75 FR 22577 - Proposed Privacy Policy Statement

    Science.gov (United States)

    2010-04-29

    ... From the Federal Register Online via the Government Publishing Office ELECTION ASSISTANCE COMMISSION Proposed Privacy Policy Statement AGENCY: U.S. Election Assistance Commission. ACTION: Notice and request for public comment on Proposed Privacy Policy Statement. SUMMARY: The U.S. Election...

  12. 14 CFR 313.6 - Energy statements.

    Science.gov (United States)

    2010-01-01

    ... action taken or to be taken upon energy efficiency and conservation. The administrative law judge or the... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Energy statements. 313.6 Section 313.6... REGULATIONS IMPLEMENTATION OF THE ENERGY POLICY AND CONSERVATION ACT § 313.6 Energy statements. (a) Each...

  13. 12 CFR 611.515 - Information statement.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Information statement. 611.515 Section 611.515 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ORGANIZATION Transfer of Authorities § 611.515 Information statement. (a) The bank and association shall prepare an information...

  14. 29 CFR 570.101 - Introductory statement.

    Science.gov (United States)

    2010-07-01

    ... Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS CHILD LABOR REGULATIONS, ORDERS AND STATEMENTS OF INTERPRETATION General Statements of Interpretation of the Child Labor...) This subpart discusses the meaning and scope of the child labor provisions contained in the Fair...

  15. 48 CFR 35.005 - Work statement.

    Science.gov (United States)

    2010-10-01

    ..., and objectives of the research or development effort; (2) Background information helpful to a clear... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.005 Work statement. (a) A clear and complete work statement concerning the area of exploration (for basic research) or the end objectives (for development...

  16. Behaviour of Metal Foam Sandwich Panels

    DEFF Research Database (Denmark)

    Alkhudery, Hayder; Virdi, Kuldeep

    Sandwich panels as used in structures comprise of a foam core enclosed by thin high strength steel faces. This paper discusses currently design formulae of local buckling behaviour of such panels using the finite element method. Multiple wave finite element models were adopted to investigate and...

  17. A National Implementation Panel for Detectable Warnings.

    Science.gov (United States)

    Joffee, E.

    1996-01-01

    This paper describes meetings by a panel of travel, access, and public transit professionals to discuss detectable warning systems (devices to notify individuals with visual impairments of hazards along their path of travel). Recommendations of the panel for universal design standards and educating communities about detectable warning systems are…

  18. Touch panel system for control applications

    International Nuclear Information System (INIS)

    The use of finger-sensitive touch panels in association with computer-generated displays for control and monitoring of the Stanford linear accelerator is discussed. This control concept has proven to be very effective. The hardware and software aspects of the Touch Panel portion of the control system are described

  19. Electronic unit for fotovoltaic solar panelling validation

    International Nuclear Information System (INIS)

    A low cost and easy to use electronic system for photovoltaic solar panelling validation is described. It measures, with a certain periodicity, voltage and current given by the panel, determines the supplied power, and every so often, its maximum valves. The unit is fitted with a data storage system which allows data recording for later analysis. (Author)

  20. Outgassing tests on iras solar panel samples

    Science.gov (United States)

    Premat, G.; Zwaal, A.; Pennings, N. H.

    1980-01-01

    Several outgassing tests were carried out on representative solar panel samples in order to determine the extent of contamination that could be expected from this source. The materials for the construction of the solar panels were selected as a result of contamination obtained in micro volatile condensable materials tests.

  1. Circuits in the Sun: Solar Panel Physics

    Science.gov (United States)

    Gfroerer, Tim

    2013-01-01

    Typical commercial solar panels consist of approximately 60 individual photovoltaic cells connected in series. Since the usual Kirchhoff rules apply, the current is uniform throughout the circuit, while the electric potential of the individual devices is cumulative. Hence, a solar panel is a good analog of a simple resistive series circuit, except…

  2. Research challenges for energy data management (panel)

    DEFF Research Database (Denmark)

    Pedersen, Torben Bach; Lehner, Wolfgang

    2013-01-01

    This panel paper aims at initiating discussion at the Second International Workshop on Energy Data Management (EnDM 2013) about the important research challenges within Energy Data Management. The authors are the panel organizers, extra panelists will be recruited before the workshop...

  3. Dynamic spatial panels : models, methods, and inferences

    NARCIS (Netherlands)

    Elhorst, J. Paul

    2012-01-01

    This paper provides a survey of the existing literature on the specification and estimation of dynamic spatial panel data models, a collection of models for spatial panels extended to include one or more of the following variables and/or error terms: a dependent variable lagged in time, a dependent

  4. 76 FR 3677 - Arts Advisory Panel

    Science.gov (United States)

    2011-01-20

    ... ARTS AND THE HUMANITIES National Endowment for the Arts Arts Advisory Panel Pursuant to Section 10(a)(2... meeting of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy Hanks..., discussion, evaluation, and recommendations on financial assistance under the National Foundation on the...

  5. 78 FR 59978 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2013-09-30

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of meeting. SUMMARY: Pursuant to Section 10(a)(2) of... meeting of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy...

  6. 78 FR 28244 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2013-05-14

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of Meetings SUMMARY: Pursuant to Section 10(a)(2) of... meetings of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy...

  7. 76 FR 23845 - Arts Advisory Panel

    Science.gov (United States)

    2011-04-28

    ... ARTS AND THE HUMANITIES National Endowment for the Arts Arts Advisory Panel Pursuant to Section 10(a)(2... meeting of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy Hanks..., evaluation, and recommendations on financial assistance under the National Foundation on the Arts and...

  8. 78 FR 64026 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2013-10-25

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of Meeting SUMMARY: Pursuant to Section 10(a)(2) of the... of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy Hanks...

  9. 77 FR 61643 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2012-10-10

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of meeting. SUMMARY: Pursuant to Section 10(a)(2) of... meetings of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy...

  10. 78 FR 21978 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2013-04-12

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of meeting. SUMMARY: Pursuant to Section 10(a)(2) of... meeting of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy...

  11. 77 FR 22613 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2012-04-16

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and the Humanities. ACTION: Notice of meeting. SUMMARY: Pursuant to Section 10(a)(2... meetings of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy...

  12. 77 FR 75672 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2012-12-21

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of Meeting. SUMMARY: Pursuant to Section 10(a)(2) of... meetings of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy...

  13. 78 FR 42982 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2013-07-18

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of Meetings SUMMARY: Pursuant to Section 10(a)(2) of... the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy Hanks...

  14. 76 FR 63664 - Arts Advisory Panel

    Science.gov (United States)

    2011-10-13

    ... ARTS AND THE HUMANITIES National Endowment for the Arts Arts Advisory Panel Pursuant to Section 10(a)(2... thirteen meetings of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy... approximate): Arts Education (application review): November 1-4, 2011 in Room 716. This meeting, from 9...

  15. 75 FR 56146 - Arts Advisory Panel; Meetings

    Science.gov (United States)

    2010-09-15

    ... ARTS AND THE HUMANITIES National Endowment for the Arts Arts Advisory Panel; Meetings Pursuant to... given that four meetings of the Arts Advisory Panel to the National Council on the Arts will be held at... are approximate): Arts Education (application review): October 4-5, 2010 in Room 716. A portion...

  16. 76 FR 50499 - Arts Advisory Panel

    Science.gov (United States)

    2011-08-15

    ... ARTS AND THE HUMANITIES National Endowment for the Arts Arts Advisory Panel Pursuant to Section 10(a)(2... meeting of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy Hanks... financial assistance under the National Foundation on the Arts and the Humanities Act of 1965, as...

  17. 78 FR 76660 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2013-12-18

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of Meeting. SUMMARY: Pursuant to Section 10(a)(2) of... meetings of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy...

  18. 77 FR 35067 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2012-06-12

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of meeting. SUMMARY: Pursuant to Section 10(a)(2) of... meetings of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy...

  19. 78 FR 26399 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2013-05-06

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of Meeting. SUMMARY: Pursuant to Section 10(a)(2) of... meeting of the Arts Advisory Panel to the National Council on the Arts will be held by teleconference...

  20. 77 FR 49026 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2012-08-15

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of meeting. SUMMARY: Pursuant to Section 10(a)(2) of... meeting of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy...

  1. 75 FR 27825 - Arts Advisory Panel

    Science.gov (United States)

    2010-05-18

    ... ARTS AND THE HUMANITIES National Endowment for the Arts Arts Advisory Panel Pursuant to Section 10(a)(2... meeting of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy Hanks... financial assistance under the National Foundation on the Arts and the Humanities Act of 1965, as...

  2. 77 FR 27803 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2012-05-11

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of meeting. SUMMARY: Pursuant to Section 10(a)(2) of... meetings of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy...

  3. 78 FR 50451 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2013-08-19

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of Meetings. SUMMARY: Pursuant to Section 10(a)(2) of... meeting of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy...

  4. 77 FR 67836 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2012-11-14

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of Meeting. SUMMARY: Pursuant to Section 10(a)(2) of... meetings of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy...

  5. 77 FR 13367 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2012-03-06

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of meeting. SUMMARY: Pursuant to Section 10(a)(2) of... of the Arts Advisory Panel to the National Council on the Arts will be held by teleconference at...

  6. 77 FR 41808 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2012-07-16

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of meeting. SUMMARY: Pursuant to Section 10(a)(2) of... meetings of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy...

  7. 78 FR 68099 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2013-11-13

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of Meeting. SUMMARY: Pursuant to Section 10(a)(2) of...- one meetings of the Arts Advisory Panel to the National Council on the Arts will be held at the...

  8. 78 FR 38410 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2013-06-26

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of Meetings. SUMMARY: Pursuant to Section 10(a)(2) of... meetings of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy...

  9. 78 FR 17942 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2013-03-25

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of meetings. SUMMARY: Pursuant to Section 10(a)(2) of... meetings of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy...

  10. 78 FR 5213 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2013-01-24

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of meeting. SUMMARY: Pursuant to Section 10(a)(2) of... meeting of the Arts Advisory Panel to the National Council on the Arts will be held at the Nancy...

  11. 77 FR 56875 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2012-09-14

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice of meeting. SUMMARY: Pursuant to Section 10(a)(2) of... meetings of the Arts Advisory Panel to the National Council on the Arts will be held by teleconference...

  12. Computer aided pantograph design for garment panels

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Discusses the difficulties and problems with manual pantograph ofgarment panels, introduces several typical pantographic ways and their characteristics both at home and abroad, presents a new pantographic method based on similar figures developed to overcome the deficiency of those methods, so as to realize computer aid automatic panel pantograph.

  13. Panel fabrication utilizing GaAs solar cells

    Science.gov (United States)

    Mardesich, N.

    1984-01-01

    The development of the GaAs solar cells for space applications is described. The activities in the fabrication of GaAs solar panels are outlined. Panels were fabricated while introducing improved quality control, soldering laydown and testing procedures. These panels include LIPS II, San Marco Satellite, and a low concentration panel for Rockwells' evaluation. The panels and their present status are discussed.

  14. Intellectual Capital Statements -When Rhetoric meets Logic

    DEFF Research Database (Denmark)

    Krag, Lotte

    of representation is calculus and mathematical rules. To illustrate the importance of describing a firm by not only using numbers the article illustrates the differences between intellectual capital statements and traditional balance sheets. The intellectual capital statement is often accused of not...... being a valid document to assess a company's value by, but this article argues that although intellectual capital statements make use of another way of presenting arguments than traditional balance sheets do they are still valid for describing a firm. The article argues that the intellectual capital...... statement uses rhetoric and thus should be analyzed accordingly instead of being compared with traditional accounting. Finally, the case of Byggeplandata is used as an illustration of how rhetoric is applied in an intellectual capital statement....

  15. Resonating Statements: Discursive acts in IT projects

    DEFF Research Database (Denmark)

    Hjelholt, Morten; Jensen, Tina Blegind

    2015-01-01

    IT projects are often complex arrangements of technological components, social actions, and organizational transformation that are difficult to manage in practice. This paper takes an analytical discourse perspective to explore the process of legitimizing IT projects. We introduce the concept of...... resonating statements to highlight how central actors navigate in various discourses over time. Particularly, the statements and actions of an IT project manager are portrayed to show how individuals can legitimize actions by connecting statements to historically produced discourses. The case study of an IT...... project in a Danish local government spans a two-year time period and demonstrates a double-loop legitimization process. First, resonating statements are produced to localize a national IT initiative to support the specificity of a local government discourse. Second, the resonating statements are used as...

  16. Micro-inverter solar panel mounting

    Science.gov (United States)

    Morris, John; Gilchrist, Phillip Charles

    2016-02-02

    Processes, systems, devices, and articles of manufacture are provided. Each may include adapting micro-inverters initially configured for frame-mounting to mounting on a frameless solar panel. This securement may include using an adaptive clamp or several adaptive clamps secured to a micro-inverter or its components, and using compressive forces applied directly to the solar panel to secure the adaptive clamp and the components to the solar panel. The clamps can also include compressive spacers and safeties for managing the compressive forces exerted on the solar panels. Friction zones may also be used for managing slipping between the clamp and the solar panel during or after installation. Adjustments to the clamps may be carried out through various means and by changing the physical size of the clamps themselves.

  17. PV panel model based on datasheet values

    DEFF Research Database (Denmark)

    Sera, Dezso; Teodorescu, Remus; Rodriguez, Pedro

    This work presents the construction of a model for a PV panel using the single-diode five-parameters model, based exclusively on data-sheet parameters. The model takes into account the series and parallel (shunt) resistance of the panel. The equivalent circuit and the basic equations of the PV cell....../panel in Standard Test Conditions (STC) are shown, as well as the parameters extraction from the data-sheet values. The temperature dependence of the cell dark saturation current is expressed with an alternative formula, which gives better correlation with the datasheet values of the power temperature...... dependence. Based on these equations, a PV panel model, which is able to predict the panel behavior in different temperature and irradiance conditions, is built and tested....

  18. The Atomic Safety and Licensing Board Panel

    International Nuclear Information System (INIS)

    Through the Atomic Energy Act, Congress made is possible for the public to get a full and fair hearing on civilian nuclear matters. Individuals who are directly affected by any licensing action involving a facility producing or utilizing nuclear materials may participate in a formal hearing, on the record, before independent judges on the Atomic Safety and Licensing Board Panel (ASLBP or Panel). Frequently, in deciding whether a license, permit, amendment, or extension should be granted to a particular applicant, the Panel members must be more than mere umpires. If appropriate, they are authorized to go beyond the issues the parties place before them in order to identify, explore, and resolve significant questions involving threats to the public health and safety that come to a board's attention during the proceedings. This brochure explains the purpose of the panel. Also addressed are: type of hearing handled; method of public participation; formality of hearings; high-level waste; other panel responsibilities and litigation technology

  19. Noise Reduction in Double‐Panel Structures by Cavity and Panel Resonance Control

    OpenAIRE

    Ho, Jen-Hsuan; Berkhoff, Arthur

    2011-01-01

    This paper presents an investigation of the cavity and the panel resonance control in a double‐panel structure. The double‐panel structure, which consists of two panels with air in the gap, is widely adopted in many applications such as aerospace due to its light weight and effective transmission‐loss at high frequency. However, the resonance of the cavity and the poor transmission‐loss at low frequency limit its noise control performance. Applying active control forces on the panels or utili...

  20. Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers

    OpenAIRE

    Yu, Lei; Todd, Nevins W.; Xing, Lingxiao; Xie, Ying; Zhang, Howard; Liu, Zhenqiu; Fang, HongBin; Zhang, Jian; Katz, Ruth L; Jiang, Feng

    2010-01-01

    Adenocarcinoma is the most common type of lung cancer, the leading cause of cancer deaths in the world. Early detection is the key to improve the survival of lung adenocarcinoma patients. We have previously shown that microRNAs were stably present in sputum and could be applied to diagnosis of lung cancer. The aim of this study was to develop a panel of microRNAs that can be used as highly sensitive and specific sputum markers for early detection of lung adenocarcinoma. This study contained t...

  1. DEGRO practical guidelines: radiotherapy of breast cancer II. Radiotherapy of non-invasive neoplasia of the breast

    International Nuclear Information System (INIS)

    To complement and update the 2007 practice guidelines of the breast cancer expert panel of the German Society of Radiation Oncology (DEGRO) for radiotherapy (RT) of breast cancer. Owing to its growing clinical relevance, in the current version, a separate paper is dedicated to non-invasive proliferating epithelial neoplasia of the breast. In addition to the more general statements of the German interdisciplinary S3 guidelines, this paper is especially focused on indication and technique of RT in addition to breast conserving surgery. The DEGRO expert panel performed a comprehensive survey of the literature comprising recently published data from clinical controlled trials, systematic reviews as well as meta-analyses, referring to the criteria of evidence-based medicine yielding new aspects compared to 2005 and 2007. The literature search encompassed the period 2008 to September 2012 using databases of PubMed and Guidelines International Network (G-I-N). Search terms were ''non invasive breast cancer'', ''ductal carcinoma in situ, ''dcis'', ''borderline breast lesions'', ''lobular neoplasia'', ''radiotherapy'' and ''radiation therapy''. In addition to the more general statements of the German interdisciplinary S3 guidelines, this paper is especially focused on indications of RT and decision making of non-invasive neoplasia of the breast after surgery, especially ductal carcinoma in situ. Among different non-invasive neoplasia of the breast only the subgroup of pure ductal carcinoma in situ (DCIS; synonym ductal intraepithelial neoplasia, DIN) is considered for further recurrence risk reduction treatment modalities after complete excision of DCIS, particularly RT following breast conserving surgery (BCS), in order to avoid a mastectomy. About half of recurrences are invasive cancers. Up to 50?% of all recurrences require salvage mastectomy. Randomized clinical trials and a huge number of mostly observational studies have unanimously demonstrated that RT significantly

  2. On the risk to low doses (<100 mSv) of ionizing radiation during medical imaging procedures - IOMP policy statement

    International Nuclear Information System (INIS)

    The science committee of International Organization for Medical Physics (IOMP) developed a policy statement on the predictions of radiation-induced cancers and cancer deaths in patients exposed to low doses (<100 mSv) of ionizing radiation during medical imaging; this statement has been approved by the IOMP council. In order to attract the attention of medical physicists, an editorial (1) titled 'Risk of Medical Imaging' that includes the said statement has recently been published in Medical Physics journal of American Association of Physicists in Medicine (AAPM). As stated, IOMP represents 80 national and 6 regional medical physics organizations and 18,000 medical physicists worldwide. The IOMP affiliated bodies/organizations in different countries (such as Association of Medical Physicists of India, AMPI) have been encouraged to reproduce the IOMP statement in their journals/newsletters for the benefit of larger community of medical physicists. The IOMP statement is reproduced below (readers may also go through the supportive literature listed in references). It is hoped that this policy statement will have some deterrent influence on the continued propagation of unproven risk related to medical imaging procedures conducted with small doses.

  3. 2014 Space Radiation Standing Review Panel

    Science.gov (United States)

    Steinberg, Susan

    2015-01-01

    The 2014 Space Radiation Standing Review Panel (from here on referred to as the SRP) participated in a WebEx/teleconference with members of the Space Radiation Program Element, representatives from the Human Research Program (HRP), the National Space Biomedical Research Institute (NSBRI), and NASA Headquarters on November 21, 2014 (list of participants is in Section XI of this report). The SRP reviewed the updated Research Plan for the Risk of Cardiovascular Disease and Other Degenerative Tissue Effects from Radiation Exposure (Degen Risk). The SRP also received a status update on the Risk of Acute and Late Central Nervous System Effects from Radiation Exposure (CNS Risk), the Risk of Acute Radiation Syndromes Due to Solar Particle Events (ARS Risk), and the Risk of Radiation Carcinogenesis (Cancer Risk). The SRP thought the teleconference was very informative and that the Space Radiation Program Element did a great job of outlining where the Element is with respect to our state of knowledge on the risks of carcinogenesis, central nervous system effects, and the risk of cardiovascular disease and other degenerative tissue effects from exposure to space radiation. The SRP was impressed with the quality of research that is being conducted and the progress the Space Radiation Program Element has made in the past year. While much work has been done, the SRP had a few remaining questions regarding the broad applicability of these findings to a manned deep space mission (in terms of cognitive function, the paradigms were still hippocampal based and also using Alzheimer disease models). The SRP believes that NASA should consider developing an approach to follow astronauts long-term (beyond retirement) for potential side-effects/risks of space exposure that may be unknown. Radiation toxicities often occur decades after exposure, and potential consequences would be missed if intensified exams stop after retirement of the astronauts. In addition, while cancer is one

  4. Screening for Ovarian Cancer: U.S. Preventive Services Task Force Reaffirmation Recommendation

    Science.gov (United States)

    ... of Internal Medicine Summaries for Patients Screening for Ovarian Cancer: U.S. Preventive Services Task Force Reaffirmation Recommendation Statement The full report is titled “Screening for Ovarian Cancer: U.S. Preventive Services Task Force Reaffirmation Recommendation Statement.” ...

  5. Attitudes and Stereotypes in Lung Cancer versus Breast Cancer

    OpenAIRE

    Sriram, N.; Mills, Jennifer; Lang, Edward; Dickson, Holli K.; Hamann, Heidi A.; Nosek, Brian A.; Schiller, Joan H.

    2015-01-01

    Societal perceptions may factor into the high rates of nontreatment in patients with lung cancer. To determine whether bias exists toward lung cancer, a study using the Implicit Association Test method of inferring subconscious attitudes and stereotypes from participant reaction times to visual cues was initiated. Participants were primarily recruited from an online survey panel based on US census data. Explicit attitudes regarding lung and breast cancer were derived from participants’ rating...

  6. Statement on the safety of ?-carotene use in heavy smokers

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS

    2012-12-01

    Full Text Available Following a request by the European Commission the Scientific Panel on Food Additives and Nutrient Sources added to Food (ANS was asked to conclude on the possible link between the ingestion of β-carotene and cancer enhancement in heavy smokers. The safety of (synthetic β-carotene [E 160a (ii] has been evaluated previously by JECFA (1975 and by the SCF (2000a.  In 2000, the SCF concluded that there were insufficient data to set a precise figure for a Tolerable Upper Intake Level (UL of β-carotene (SCF, 2000b. Unexpectedly, two independent trials revealed that heavy smokers (at least 1 package/day for 36 years on average receiving long-term β-carotene (20 mg/day supplementation or β-carotene (30 mg/day + retinol (25 000 International Unit (IU vitamin A supplementation, showed increased rather than decreased incidences of lung cancer. A meta-analysis of randomized controlled trials (RCT demonstrated absence of any protective effect associated with β-carotene supplementation with regard to cancer risk. Epidemiological studies reported no increased lung cancer incidence in heavy smokers at supplemental dose levels of β-carotene varying from 6 – 15 mg/day for about 5 up to 7 years. The Panel concluded that exposure to β-carotene from its use as food additive and as food supplement at a level below 15 mg/day do not give rise to concerns about adverse health effects in the general population, including heavy smokers.

  7. 78 FR 73587 - Taxpayer Advocacy Panel Meeting Cancellation

    Science.gov (United States)

    2013-12-06

    ... Internal Revenue Service Taxpayer Advocacy Panel Meeting Cancellation AGENCY: Internal Revenue Service (IRS... the open meeting of the Taxpayer Advocacy Panel Notices and Correspondence Project Committee scheduled... Advocacy Panel. BILLING CODE 4830-01-P...

  8. 78 FR 73587 - Taxpayer Advocacy Panel; Meeting Cancellation.

    Science.gov (United States)

    2013-12-06

    ... Internal Revenue Service Taxpayer Advocacy Panel; Meeting Cancellation. AGENCY: Internal Revenue Service... cancellation of the open meeting of the Taxpayer Advocacy Panel Taxpayer Communications Project Committee..., Acting Director, Taxpayer Advocacy Panel. BILLING CODE 4830-01-P...

  9. 78 FR 73586 - Taxpayer Advocacy Panel Meeting Cancellation

    Science.gov (United States)

    2013-12-06

    ... Internal Revenue Service Taxpayer Advocacy Panel Meeting Cancellation AGENCY: Internal Revenue Service (IRS... the open meeting of the Taxpayer Advocacy Panel Taxpayer Assistance Center Improvements Project..., Taxpayer Advocacy Panel. BILLING CODE 4830-01-P...

  10. PVT Panels. Fully renewable and competitive

    International Nuclear Information System (INIS)

    A photovoltaic/thermal (PVT) panel is a combination of photovoltaic cells with a solar thermal collector, generating solar electricity and solar heat simultaneously. PVT panels generate more solar energy per unit surface area than a combination of separate PV panels and solar thermal collectors, and share the aesthetic advantage of PV. After several years of research, PVT panels have been developed into a product that is now ready for market introduction. One of the most promising system concepts, consisting of 25 m2 of PVT panels and a ground coupled heat pump, has been simulated in TRNSYS, and has been found to be able to fully cover both the building related electricity and heat consumption, while keeping the long-term average ground temperature constant. The cost and payback time of such a system have been determined; it has been found that the payback time of this system is approximately two-thirds of the payback time of an identical system but with 21 m2 of PV panels and 4 m2 of solar thermal collectors. Finally, by looking at the expected growth in the PV and solar thermal collector market, the market potential for for PVT panels has been found to be very large

  11. Statement on the safety of synthetic zeaxanthin as an ingredient in food supplements

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2012-10-01

    Full Text Available

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to update its opinion on the safety of synthetic zeaxanthin as a novel food ingredient in food supplements in the light of additional information provided by the applicant. In its previous opinion of 2008, the Panel concluded that based on the available data, the safety of zeaxanthin as an ingredient in food supplements at the proposed use level of up to 20 mg/person per day has not been established. In response to the EFSA Opinion of 2008, the applicant provided a two-generation reproduction toxicity study with synthetic zeaxanthin in rats and twenty-two additional references including some mechanistic studies related to carotenoids and lung cancer risk. Although neither animal nor human data on the lung cancer risk of zeaxanthin are available, on the current data available the Panel considers it is unlikely that supplemental intake of zeaxanthin would increase the risk of lung cancer in heavy smokers. The Panel identifies a NOAEL at 150 mg/kg bw per day in the two-generation reproduction toxicity study and has no concerns with regard to genotoxicity. Given the absence of a chronic toxicity/carcinogenicity study, the Panel applies an uncertainty factor of 200 on the NOAEL in the two-generation study. This results in 0.75 mg/kg bw per day for synthetic zeaxanthin corresponding to a daily intake of 53 mg for a person with a body weight of 70 kg. The Panel concludes that based on the available data, intakes of 0.75 mg/kg bw per day for synthetic zeaxanthin, corresponding to a daily intake of 53 mg for a person with a body weight of 70 kg, do not raise safety concerns. Therefore, the use levels proposed by the applicant do not raise safety concerns.

  12. National Cancer Moonshot Initiative platform | Office of Cancer Genomics

    Science.gov (United States)

    As part of the Vice President’s National Cancer Moonshot Initiative, the National Cancer Institute has launched an online engagement platform to enable the research community and the public to submit cancer research ideas to a Blue Ribbon Panel of scientific experts. Any member of the public is encouraged to submit his or her ideas for reducing the incidence of cancer and developing better ways to prevent, treat, and cure all types of cancer. Research ideas may be submitted in the following areas:

  13. The 7 Aarhus Statements on Climate Change

    DEFF Research Database (Denmark)

    Basse, Ellen Margrethe; Svenning, J.-C.; Olesen, Jørgen E;

    2009-01-01

    ; Nanotechnology solutions for a sustainable future; Citizens and society, and The Arctic. The main responsible scientists for the seven conference themes and representatives from the think-tank CONCITO delivered 'The 7 Aarhus Statements on Climate Change' as part of the closing session of the conference. The...... statements were also communicated to the Danish Government as well as to the press. This article is the product of the collective subsequent work of the seven theme responsibles and is a presentation of each theme statement in detail, emphasizing the current state of knowledge and how it may be used to...

  14. Development of a plasma panel radiation detector

    CERN Document Server

    Ball, R; Ben-Moshe, M; Benhammou, Y; Bensimon, R; Chapman, J W; Etzion, E; Ferretti, C; Friedman, P S; Levin, D S; Silver, Y; Varner, R L; Weaverdyck, C; Wetzel, R; Zhou, B; Anderson, T; McKinny, K; Bentefour, E H

    2014-01-01

    This article reports on an investigation of a radiation detector based on plasma display panel technology. The plasma panel sensor (PPS) is a variant of micropattern gas radiation detectors. PPS components are non-reactive and intrinsically radiation-hard materials, such as glass substrates, metal electrodes and inert gas mixtures. Plasma display panels used as detectors were tested with cosmic ray muons, beta rays and gamma rays, protons, and thermal neutrons. The results demonstrated risetimes and time resolution of a few nanoseconds, as well as spatial resolution compatible with the pixel pitch.

  15. Development of a plasma panel radiation detector

    Energy Technology Data Exchange (ETDEWEB)

    Ball, R. [University of Michigan, Department of Physics, Ann Arbor, MI 48109 (United States); Beene, J.R. [Oak Ridge National Laboratory, Physics Division, Oak Ridge, TN 737831 (United States); Ben-Moshe, M.; Benhammou, Y.; Bensimon, B. [Tel Aviv University, Beverly and Raymond Sackler School of Physics and Astronomy, Tel Aviv (Israel); Chapman, J.W. [University of Michigan, Department of Physics, Ann Arbor, MI 48109 (United States); Etzion, E. [Tel Aviv University, Beverly and Raymond Sackler School of Physics and Astronomy, Tel Aviv (Israel); Ferretti, C. [University of Michigan, Department of Physics, Ann Arbor, MI 48109 (United States); Friedman, P.S. [Integrated Sensors, LLC, Ottawa Hills, OH 43606 (United States); Levin, D.S. [University of Michigan, Department of Physics, Ann Arbor, MI 48109 (United States); Silver, Y. [Tel Aviv University, Beverly and Raymond Sackler School of Physics and Astronomy, Tel Aviv (Israel); Varner, R.L. [Oak Ridge National Laboratory, Physics Division, Oak Ridge, TN 737831 (United States); Weaverdyck, C.; Wetzel, R.; Zhou, B. [University of Michigan, Department of Physics, Ann Arbor, MI 48109 (United States); Anderson, T.; McKinny, K. [GE Measurement and Control, Reuter-Stokes Product Line, Twinsburg, OH 44087 (United States); Bentefour, E.H. [Ion Beam Applications S.A., Louvain La Neuve, B-1348 Belgium (Belgium)

    2014-11-11

    This article reports on the development and experimental results of commercial plasma display panels adapted for their potential use as micropattern gas radiation detectors. The plasma panel sensor (PPS) design and materials include glass substrates, metal electrodes and inert gas mixtures which provide a physically robust, hermetically sealed device. Plasma display panels used as detectors were tested with cosmic ray muons, beta rays and gamma rays, protons, and thermal neutrons. The results demonstrated rise times and time resolution of a few nanoseconds, as well as sub-millimeter spatial resolution compatible with the pixel pitch.

  16. Development of a plasma panel radiation detector

    Energy Technology Data Exchange (ETDEWEB)

    Ball, Robert [University of Michigan; Beene, James R [ORNL; Ben Moshe, M. [Tel Aviv University; Benhammou, Yan [Tel Aviv University; Bensimon, B [Tel Aviv University; Chapman, J. Wehrley [University of Michigan; Etzion, E [Tel Aviv University; Ferretti, Claudio [University of Michigan; Friedman, Dr. Peter S. [Integrated Sensors, LLC; Levin, Daniel S. [University of Michigan; Silver, Yiftah [Tel Aviv University; Weaverdyck, Curtis [University of Michigan; Wetzel, R. [University of Michigan; Zhou, Bing [University of Michigan; Anderson, T [GE Measurement and Control Solutions; McKinny, K [GE Measurement and Control Solutions; Bentefour, E [Ion Beam Applications

    2014-11-01

    This article reports on the development and experimental results of commercial plasma display panels adapted for their potential use as micropattern gas radiation detectors. The plasma panel sensor (PPS) design and materials include glass substrates, metal electrodes and inert gas mixtures which provide a physically robust, hermetically sealed device. Plasma display panels used as detectors were tested with cosmic ray muons, beta rays and gamma rays, protons, and thermal neutrons. The results demonstrated rise times and time resolution of a few nanoseconds, as well as sub-millimeter spatial resolution compatible with the pixel pitch.

  17. Differing professional opinions: 1987 Special Review Panel

    International Nuclear Information System (INIS)

    In mid-1987, the Executive Director for Operations of the US Nuclear Regulatory Commission appointed a Special Review Panel to review the existing NRC policy for expressing differing professional views and to recommend possible improvements to the policy, if warranted. Through its own efforts and those of three subpanels and three consultants, the Panel developed recommendations for changes and improvements in five major areas. This report presents those recommendations, along with a detailed explanation of the Panel's findings, copies of the reports of the subpanels and consultants, and the results of a survey of NRC non-clerical employees on the issue

  18. Design for SOP AMOLED display panel

    Science.gov (United States)

    Ma, Hai-Ying; Xu, Bu-Heng; Wu, Chun-Ya; Meng, Zhi-Guo; Xiong, Shao-Zhen; Zhang, Li-Zhu

    2005-07-01

    A novel full color SOP (system on panel) AMOLED display based on the MIUC polycrystalline silicon TFT technique, and a new control circuit for the panel, which can deal with both VGA and DVI input signals have been developed. To realize gray-scale a sub-frame technique has been designed and implemented by FPGA device, in which an I2C module has been inserted. Through actual circuit, the whole design has been proven and the advantages of the SOP AMOLED display panel have been confirmed.

  19. Design for SOP AMOLED display panel

    Institute of Scientific and Technical Information of China (English)

    MA Hai-ying; XU Bu-heng; WU Chun-ya; MENG Zhi-guo; XIONG Shao-zhen; ZHANG Li-zhu

    2005-01-01

    A novel full color SOP(system on panel) AMOLED display based on the MIUC polycrystalline silicon TFT technique, and a new control circuit for the panel, which can deal with both VGA and DVI input signals have been developed.To realize gray-scale a sub-frame technique has been designed and implemented by FPGA device,in which an I2C module has been inserted.Through actual circuit,the whole design has been proven and the advantages of the SOP AMOLED display panel have been confirmed.

  20. Prognostic microRNAs in cancer tissue from patients operated for pancreatic cancer--five microRNAs in a prognostic index

    DEFF Research Database (Denmark)

    Schultz, Nicolai A; Andersen, Klaus; Roslind, Anne;

    2012-01-01

    The aim of the present study was to identify a panel of microRNAs (miRNAs) that can predict overall survival (OS) in non micro-dissected cancer tissues from patients operated for pancreatic cancer (PC).......The aim of the present study was to identify a panel of microRNAs (miRNAs) that can predict overall survival (OS) in non micro-dissected cancer tissues from patients operated for pancreatic cancer (PC)....

  1. A novel serum microRNA panel to discriminate benign from malignant ovarian disease.

    LENUS (Irish Health Repository)

    Langhe, Ream

    2015-01-28

    Ovarian cancer is the seventh most common cancer in women and the most frequent cause of gynaecological malignancy-related mortality in women. Currently, no standardized reliable screening test exists. MicroRNA profiling has allowed the identification of signatures associated with diagnosis, prognosis and response to treatment of human tumours. The aim of this study was to determine if a microRNA signature could distinguish between malignant and benign ovarian disease. A training set of 5 serous ovarian carcinomas and 5 benign serous cystadenomas were selected for the initial experiments. The validation set included 20 serous ovarian carcinomas and 20 benign serous cystadenomas. The serum\\/plasma focus microRNA Exiqon panel was used for the training set. For the validation set a pick and mix Exiqon panel, which focuses on microRNAs of interest was used. A panel of 4 microRNAs (let-7i-5p, miR-122, miR-152-5p and miR-25-3p) was significantly down regulated in cancer patients. These microRNAs target WNT signalling, AKT\\/mTOR and TLR-4\\/MyD88, which have previously been found to play a role in ovarian carcinogenesis and chemoresistance. let-7i-5p, miR-122, miR-152-5p and miR-25-3p could act as diagnostic biomarkers in ovarian cancer.

  2. Cash flow statement in financial statement analysis for small and medium sized enterprises

    OpenAIRE

    Hyvönen, Valtteri

    2016-01-01

    BACKGROUND AND MOTIVATION A new EU's accounting directive (2013/34/EU) focuses on the reliefs for financial statement disclosures of SMEs. Although directive 2013/34/EU is not taking a stand on cash flow preparation, in Finland a working group set by the Ministry of employment and economy has proposed that only large companies would be obliged to prepare cash flow statement as a part of financial statement. The Finnish parliament accepted the proposal in the part of renewed accounting law...

  3. 21 CFR 201.61 - Statement of identity.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Statement of identity. 201.61 Section 201.61 Food...: GENERAL LABELING Labeling Requirements for Over-the-Counter Drugs § 201.61 Statement of identity. (a) The... features a statement of the identity of the commodity. (b) Such statement of identity shall be in terms...

  4. 21 CFR 801.61 - Statement of identity.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Statement of identity. 801.61 Section 801.61 Food... DEVICES LABELING Labeling Requirements for Over-the-Counter Devices § 801.61 Statement of identity. (a... principal features a statement of the identity of the commodity. (b) Such statement of identity shall be...

  5. 7 CFR 1980.445 - Periodic financial statements and audits.

    Science.gov (United States)

    2010-01-01

    ... the lender's analysis of the statements to the Agency. (a) Audited financial statements. Except as... 7 Agriculture 14 2010-01-01 2009-01-01 true Periodic financial statements and audits. 1980.445... Program § 1980.445 Periodic financial statements and audits. All borrowers will be required to...

  6. 28 CFR 10.2 - Language of registration statement.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Language of registration statement. 10.2... ON ACTIVITIES WITHIN THE UNITED STATES Registration Statement § 10.2 Language of registration statement. Registration statements must be in English if possible. If in a foreign language they must...

  7. 40 CFR 156.68 - First aid statement.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false First aid statement. 156.68 Section... aid statement. (a) Product as sold and distributed. Each product must bear a first aid statement if... with water prior to use, the label may also include a statement describing how the first aid...

  8. Council approves statement on natural hazards

    Science.gov (United States)

    As a scientific society, AGU may adopt positions of advocacy on geophysical science isues based on their intrinsic merits and needs. On December 18, 1996, the AGU Council approved a Union position statement regarding scientific research and education in natural hazards. The complete position statement follows and also is posted at the Union Web Site, http://www.agu.org. Other Union position statements and information about proposing a position statement are in the AGU Handbook and at the Union Web Site.Few locations on Earth are immune from droughts, storms, floods, fires, earthquakes, landslides, tsunamis, volcanic eruptions, sea level changes, water course changes, atmospheric electrical storms, and impacts from comets and asteroids. Humans and technological systems are also threatened by natural hazards that occur in space. The effects of space weather, for example, can wreak havoc with the satellites we use to provide communications, weather forecasts, and defense and positioning information.

  9. Financial Statement Analysis for Nonprofit Organizations

    OpenAIRE

    Travaglini, Claudio

    2007-01-01

    A financial statement analysis framework for nonprofit organizations is proposed, based on Nonprofit Commission of Certified Public Accountants Association (Commissione Aziende Nonprofit Ordine Nazionale Dottori Commercialisti) for Italian Nonprofits.

  10. Briefing statement : Waubay Wetland Management District

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This briefing statement details the Waubay National Wildlife Refuge, staff, funding, history, refuges facts and maps, general management, public use and depredation...

  11. Annual report and accounting statements 2007: ELETROBRAS

    International Nuclear Information System (INIS)

    This document reports the actives of the ELETROBRAS during the year 2007 related to: electricity market, international activities, strategic planning, financial indicators, business analysis, relationship with investors, energy marketing, operational research, technological development, financial statements, social responsibility and environment

  12. Online, Batch and CICS Social Security Statement

    Data.gov (United States)

    Social Security Administration — A database that contains client preference information for the SSA initiated Social Security Statement as well as other data including SSN, disposition for paper SS...

  13. Panel backs next-generation synchrotron

    CERN Multimedia

    Service, R F

    1999-01-01

    A key federal panel recommended continued research into development of a fourth-generation synchrotron. It would be capable of creating x-ray pulses billions of times more intense than current designs (1 page).

  14. ATR FTIR Mapping of Leather Fiber Panels

    Science.gov (United States)

    Tondi, G.; Grünewald, T.; Petutschnigg, A.; Schnabel, T.

    2015-01-01

    Leather fiber panels are very promising materials for many applications, not only for the easy availability of the constituents but also for their outstanding fi re-retardant properties. These innovative composite panels can be an excellent material for building insulation, and in recent times, the interest of industries in this composite board has considerably arisen. For this reason the discrimination of the components in the leather fiber panels is becoming fundamental in order to ensure their homogeneous properties. A method to characterize the surface of these materials is then required. An ATR FTIR mapping system for the leather fiber panels has been performed with a Perkin-Elmer microscope coupled with a Frontier FTIR spectrometer. The system has successfully allowed transforming the optical image to a chemical one. This technique can be considered as a right tool for routine controls of the surface quality, especially when the leather shavings cannot be optically distinguished.

  15. Medical Expenditure Panel Survey Household Component

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Medical Expenditure Panel Survey (MEPS) Household Component (HC) collects data from a sample of families and individuals in selected communities across the...

  16. 78 FR 50037 - Hydrographic Services Review Panel

    Science.gov (United States)

    2013-08-16

    ... from individuals with expertise in navigation data, products and services; marine cartography and... National Oceanic and Atmospheric Administration Hydrographic Services Review Panel AGENCY: National Ocean Service, National Oceanic and Atmospheric Administration (NOAA), Department of Commerce. ACTION: Notice...

  17. 75 FR 20809 - Hydrographic Services Review Panel

    Science.gov (United States)

    2010-04-21

    ... expertise in navigation data, products and services; coastal management; fisheries management; coastal and... National Oceanic and Atmospheric Administration Hydrographic Services Review Panel AGENCY: National Ocean Service, National Oceanic and Atmospheric Administration (NOAA), Department of Commerce. ACTION: Notice...

  18. The Panel Study of Income Dynamics (PSID)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Panel Study of Income Dynamics (PSID) began in 1968 with a nationally representative sample of over 18,000 individuals living in 5,000 families in the United...

  19. JTEC panel on display technologies in Japan

    Science.gov (United States)

    Tannas, Lawrence E., Jr.; Glenn, William E.; Credelle, Thomas; Doane, J. William; Firester, Arthur H.; Thompson, Malcolm

    1992-01-01

    This report is one in a series of reports that describes research and development efforts in Japan in the area of display technologies. The following are included in this report: flat panel displays (technical findings, liquid crystal display development and production, large flat panel displays (FPD's), electroluminescent displays and plasma panels, infrastructure in Japan's FPD industry, market and projected sales, and new a-Si active matrix liquid crystal display (AMLCD) factory); materials for flat panel displays (liquid crystal materials, and light-emissive display materials); manufacturing and infrastructure of active matrix liquid crystal displays (manufacturing logistics and equipment); passive matrix liquid crystal displays (LCD basics, twisted nematics LCD's, supertwisted nematic LCD's, ferroelectric LCD's, and a comparison of passive matrix LCD technology); active matrix technology (basic active matrix technology, investment environment, amorphous silicon, polysilicon, and commercial products and prototypes); and projection displays (comparison of Japanese and U.S. display research, and technical evaluation of work).

  20. Modelling Firm Innovation using Panel Probit Estimators.

    OpenAIRE

    Mark N. Harris; Mark Rogers; Anthony Siouclis

    2001-01-01

    Firm-level innovation is investigated using three probit panel estimators, which control for unobserved heterogeneity, and a standard probit estimator. Results indicate the standard probit model is misspecified and that inter-firm networks are important for innovation.

  1. Initial report from the ICFA Neutrino Panel

    CERN Document Server

    Cao, J; Duchesneau, D; Funchal, R; Geer, S; Kim, S B; Kobayashi, T; Long, K; Maltoni, M; Mezzetto, M; Mondal, N; Shiozawa, M; Sobczyk, J; Tanaka, H A; Wascko, M; Zeller, G

    2014-01-01

    In July 2013 ICFA established the Neutrino Panel with the mandate "To promote international cooperation in the development of the accelerator-based neutrino-oscillation program and to promote international collaboration in the development a neutrino factory as a future intense source of neutrinos for particle physics experiments". This, the Panel's Initial Report, presents the conclusions drawn by the Panel from three regional "Town Meetings" that took place between November 2013 and February 2014. After a brief introduction and a short summary of the status of the knowledge of the oscillation parameters, the report summarises the approved programme and identifies opportunities for the development of the field. In its conclusions, the Panel recognises that to maximise the discovery potential of the accelerator-based neutrino-oscillation programme it will be essential to exploit the infrastructures that exist at CERN, FNAL and J-PARC and the expertise and resources that reside in laboratories and institutes ar...

  2. The CRRES high efficiency solar panel

    International Nuclear Information System (INIS)

    This paper reports on the High Efficiency Solar Panel (HESP) experiments which is to provide both engineering and scientific information concerning the effects of space radiation on advanced gallium arsenide (GaAs) solar cells. The HESP experiment consists of an ambient panel, and annealing panel and a programmable load. This experiment, in conjunction with the radiation measurement experiments abroad the CREES, provides the first opportunity to simultaneously measure the trapped radiation belts and the results of radiation damage to solar cells. The engineering information will result in a design guide for selecting the optimum solar array characteristics for different orbits and different lifetimes. The scientific information will provide both correlation of laboratory damage effects to space damage effects and a better model for predicting effective solar cell panel lifetimes

  3. Characteristics of DSSC Panels with Silicone Encapsulant

    Directory of Open Access Journals (Sweden)

    Jun-Gu Kang

    2015-01-01

    Full Text Available Dye-sensitized solar cells (DSSC allow light transmission and the application of various colors that make them especially suitable for building-integrated PV (BIPV application. In order to apply DSSC modules to windows, the module has to be panelized: a DSSC module should be protected with toughened glass on the entire surface. Up to the present, it seems to be common to use double glazing with DSSC modules, with air gaps between the glass pane and the DSSC modules. Few studies have been conducted on the characteristics of various glazing methods with DSSC modules. This paper proposes a paneling method that uses silicone encapsulant, analyzing the performance through experimentation. Compared to a multilayered DSSC panel with an air gap, the encapsulant-applied panel showed 6% higher light transmittance and 7% higher electrical efficiency. The encapsulant also prevented electrolyte leakage by strengthening the seals in the DSSC module.

  4. Fiber Reinforced Composite Cores and Panels

    Science.gov (United States)

    Day, Stephen W. (Inventor); Campbell, G. Scott (Inventor); Tilton, Danny E. (Inventor); Stoll, Frederick (Inventor); Sheppard, Michael (Inventor); Banerjee, Robin (Inventor)

    2013-01-01

    A fiber reinforced core panel is formed from strips of plastics foam helically wound with layers of rovings to form webs which may extend in a wave pattern or may intersect transverse webs. Hollow tubes may replace foam strips. Axial rovings cooperate with overlying helically wound rovings to form a beam or a column. Wound roving patterns may vary along strips for structural efficiency. Wound strips may alternate with spaced strips, and spacers between the strips enhance web buckling strength. Continuously wound rovings between spaced strips permit folding to form panels with reinforced edges. Continuously wound strips are helically wrapped to form annular structures, and composite panels may combine both thermoset and thermoplastic resins. Continuously wound strips or strip sections may be continuously fed either longitudinally or laterally into molding apparatus which may receive skin materials to form reinforced composite panels.

  5. Robust estimation procedure in panel data model

    International Nuclear Information System (INIS)

    The panel data modeling has received a great attention in econometric research recently. This is due to the availability of data sources and the interest to study cross sections of individuals observed over time. However, the problems may arise in modeling the panel in the presence of cross sectional dependence and outliers. Even though there are few methods that take into consideration the presence of cross sectional dependence in the panel, the methods may provide inconsistent parameter estimates and inferences when outliers occur in the panel. As such, an alternative method that is robust to outliers and cross sectional dependence is introduced in this paper. The properties and construction of the confidence interval for the parameter estimates are also considered in this paper. The robustness of the procedure is investigated and comparisons are made to the existing method via simulation studies. Our results have shown that robust approach is able to produce an accurate and reliable parameter estimates under the condition considered

  6. Study on noise of precision panel saw

    Institute of Scientific and Technical Information of China (English)

    HUWan-yi; QIYing-jie; ZHANGZhao-hao; QIXiao-jie

    2003-01-01

    According to ZBJ65015-89 standard about noise level testing method of woodworking toot, the noise testing for MJg0# and MJCl125 precision panel saws was conducted by using model ND2 precision soundqevel apparatus and double frequency wave filter. The testing results showed that the unloaded running noise source of precision panel saw was mainly from main saw blade and its aeromechanic noise was the largest. The rotating speed was determined as an important factor to impact dynamic characters of precision panel saw as the unloaded running noise increased along with speed increasing. For reducing noise of precision panel saw, the first important way is to reduce the aeromechanic noise produced by main saw blade rotating at high speed; based on assuring the processing precision, choosing tow speed is a better way to drop dawn noise; from the view of design, the diameter of clamping lid is better of half of outer diameter of main saw blade.

  7. DECWEB - Internet Fiscal Statement Submission

    Directory of Open Access Journals (Sweden)

    Mihai Ianciu

    2009-12-01

    Full Text Available

    The latest technologies are used not only in business, considered the most dynamic field of activity, but also in Governmental strategies of interaction with the civil society and  the business environment. The governmental functional and technological requirements created new concepts and approaches of electronic business (G2G, G2B, and G2C. In Romania, the Ministry of Communications and Information Technology was the trend setter. It developed a large number of proofs of concept and pilot projects covering a wide area of services that needed to evolve electronically. Together with the Ministry of Public Finance, it defined the requirements and specifications for DECWEB, the programme that allows companies to submit their fiscal statements via Internet.

    DECWEB system is a keystone programme for the Ministry of Public Finance on its way towards moving administration and services for society to information age. Highly awarded, the first DECWEB initiative was a successful proof of concept and it needed to be upgraded to a new professional version with extended functionalities, higher flexibility and advanced security mechanisms. This paper describes the DECWEB project and how technology and professional services enhanced Governmental activities, why the project was such a success and how it will evolve.

  8. DECWEB - Internet Fiscal Statement Submission

    Directory of Open Access Journals (Sweden)

    Mihai Ianciu

    2009-12-01

    Full Text Available The latest technologies are used not only in business, considered the most dynamic field of activity, but also in Governmental strategies of interaction with the civil society and  the business environment. The governmental functional and technological requirements created new concepts and approaches of electronic business (G2G, G2B, and G2C. In Romania, the Ministry of Communications and Information Technology was the trend setter. It developed a large number of proofs of concept and pilot projects covering a wide area of services that needed to evolve electronically. Together with the Ministry of Public Finance, it defined the requirements and specifications for DECWEB, the programme that allows companies to submit their fiscal statements via Internet. DECWEB system is a keystone programme for the Ministry of Public Finance on its way towards moving administration and services for society to information age. Highly awarded, the first DECWEB initiative was a successful proof of concept and it needed to be upgraded to a new professional version with extended functionalities, higher flexibility and advanced security mechanisms. This paper describes the DECWEB project and how technology and professional services enhanced Governmental activities, why the project was such a success and how it will evolve.

  9. Statement of Agreements Registered With The Agency

    International Nuclear Information System (INIS)

    This document contains a statement of all the agreements which had been registered with the Agency by 30 June 1960 under the Regulations for the Registration of Agreements adopted by the Board of Governors in implementation of Article XXII. B of the Statute. In compliance with Article VI of the Regulations this statement is hereby transmitted to all Members of the Agency for their information. A copy is also being sent to the Secretary-General of the United Nations

  10. Financial Statements and book-closing

    OpenAIRE

    Boušová, Kateřina

    2013-01-01

    The bachelor thesis deals with the process of creating financial statement preceded by certain preparation works and closing of individual accounts. In its initial part, the thesis describes legal regulations governing the area of the financial statement process. Then it informs about the individual steps of preparation works, which precede closing of accounts. These operations are important for objective accuracy and completeness of accountancy. Next part of the thesis describes accounting s...

  11. How to Write an Outcome Statement.

    Science.gov (United States)

    Dickerson, Pamela S

    2015-09-01

    Educators within the health professions are increasingly asked to demonstrate outcomes of educational interventions. Within academia and clinical practice, educators are expected to measure, monitor, and, in many cases, report outcomes of their work. As continuing education transitions to a more deliberate emphasis on outcomes, common questions include how to identify and measure outcomes and how to write an outcome statement. This article will focus on how to write an outcome statement. PMID:26352037

  12. Transparency in Central Bank Financial Statement Disclosures

    OpenAIRE

    Kenneth Sullivan

    2000-01-01

    The IMF's development of the Code of Good Practices on Transparency in Monetary and Financial Policies and the introduction of safeguards assessments have increased emphasis on transparency of the disclosures made in central bank financial statements. This paper, which updates WP/00/186, looks at the disclosure requirements for central banks under International Financial Reporting Standards and provides practical guidance for those responsible for preparing central bank financial statements.

  13. The Benefits of Financial Statement Comparability

    OpenAIRE

    de Franco, Gus; Kothari, S.P.; Verdi, Rodrigo

    2011-01-01

    Investors, regulators, academics, and researchers all emphasize the importance of financial statement comparability. However, an empirical construct of comparability is typically not specified. In addition, little evidence exists on the benefits of comparability to users. This study attempts to fill these gaps by developing a measure of financial statement comparability. Empirically, this measure is positively related to analyst following and forecast accuracy, and negatively related to analy...

  14. LEGAL-EASE:Analyzing Chinese Financial Statements

    Institute of Scientific and Technical Information of China (English)

    EDWARD; MA

    2008-01-01

    In this article,we will focus on under- standing and analyzing the typical accounts of Chinese financial statements,including the balance sheet and income statement. Accounts are generally incorrectly prepared. This can be due to several factors,incom- petence,as well as more serious cases of deliberate attempts to deceive.Regardless, accounts can be understood and errors or specific acts of misrepresentation uncovered. We will conduct some simple analysis to demonstrate how these can be spotted.

  15. Is the statement of Murphy's Law valid?

    OpenAIRE

    Chatterjee, Atanu

    2015-01-01

    Murphy's Law is $not$ a law in the formal sense yet popular science often compares it with the Second Law of Thermodynamics as both the statements point toward a more disorganized state with time. In this paper, we first construct a mathematically equivalent statement for Murphy's Law and then disprove it using the intuitive idea that energy differences will level off along the paths of steepest descent, or along trajectories of least action.

  16. Culture and Corporate Governance Statement Disclosure

    OpenAIRE

    Theo Christopher; Salleh Hassan

    2005-01-01

    This study examines the influence of culture on Corporate Governance Statement disclosure in the annual reports of the major airline companies in Malaysia and Australia. The cultural research of Hofstede (1980) and the accounting value dimensions of Gray (1988) imply that Malaysian Airlines, from a large power distance country, will disclose less Corporate Governance Statement information in their annual report than Qantas Airlines, from a small power distance country. The results obtained fr...

  17. THE 2003 SUPERMARKET PANEL ANNUAL REPORT

    OpenAIRE

    Kinsey, Jean D.; Jacobson, Elaine M.; Behl, Ajay S.; Seltzer, Jonathan M.

    2003-01-01

    Executive Summary The Food Industry Center established the Supermarket Panel in 1998 as the basis for an ongoing study of the supermarket industry. Since 2000 the core of the Panel has been a random sample of stores drawn from the approximately 32,000 supermarkets in the U.S. that accept food stamps. The purpose of collecting data on supermarket operations and performance is to: Provide timely, useful information for the industry through benchmark reports and annual summaries, trends on key i...

  18. THE 2002 SUPERMARKET PANEL ANNUAL REPORT

    OpenAIRE

    King, Robert P.; Jacobson, Elaine M.; Seltzer, Jonathan M.

    2002-01-01

    The Supermarket Panel collects data annually from individual supermarkets on store characteristics, operations, and performance. It was established in 1998 by the Food Industry Center as the basis for ongoing study of the supermarket industry. The Panel is unique because the unit of analysis is the individual store and the same stores are tracked over time. This makes it possible to analyze the processes by which new technologies, business practices, and competitive forces are changing the in...

  19. THE 2001 SUPERMARKET PANEL ANNUAL REPORT

    OpenAIRE

    King, Robert P.; Jacobson, Elaine M.; Selzer, Jonathan M.

    2001-01-01

    The Supermarket Panel collects data annually from individual supermarkets on store characteristics, operations, and performance. It was established in 1998 by the Food Industry Center as the basis for ongoing study of the supermarket industry. The Panel is unique because the unit of analysis is the individual store and the same stores are tracked over time. This makes it possible to analyze the processes by which new technologies, business practices, and competitive forces are changing the in...

  20. Creating a Framework for Medical Professionalism: An Initial Consensus Statement From an Arab Nation.

    Science.gov (United States)

    Abdel-Razig, Sawsan; Ibrahim, Halah; Alameri, Hatem; Hamdy, Hossam; Haleeqa, Khaled Abu; Qayed, Khalil I; Obaid, Laila O; Al Fahim, Maha; Ezimokhai, Mutairu; Sulaiman, Nabil D; Fares, Saleh; Al Darei, Maitha Mohammed; Shahin, Nhayan Qassim; Al Shamsi, Noora Abdulla Omran; Alnooryani, Rashed Arif; Al Falahi, Salama Zayed

    2016-05-01

    Background Medical professionalism has received increased worldwide attention, yet there is limited information on the applicability and utility of established Western professionalism frameworks in non-Western nations. Objective We developed a locally derived consensus definition of medical professionalism for the United Arab Emirates (UAE), which reflects the cultural and social constructs of the UAE and the Middle East. Methods We used a purposive sample of 14 physicians working in the UAE as clinical and education leaders. This expert panel used qualitative methods, including the world café, nominal group technique, the Delphi method, and an interpretive thematic analysis to develop the consensus statement. Results The expert panel defined 9 attributes of medical professionalism. There was considerable overlap with accepted Western definitions, along with important differences in 3 aspects: (1) the primacy of social justice and societal rights; (2) the role of the physician's personal faith and spirituality in guiding professional practices; and (3) societal expectations for professional attributes of physicians that extend beyond the practice of medicine. Conclusions Professionalism is a social construct influenced by cultural and religious contexts. It is imperative that definitions of professionalism used in the education of physicians in training and in the assessment of practicing physicians be formulated locally and encompass specific competencies relevant to the local, social, and cultural context for medical practice. Our goal was to develop a secular consensus statement that encompasses culture and values relevant to professionalism for the UAE and the Arab region. PMID:27168882

  1. Unveiling a novel biomarker panel for diagnosis and classification of well-differentiated thyroid carcinomas.

    Science.gov (United States)

    Paricharttanakul, N Monique; Saharat, Kittirat; Chokchaichamnankit, Daranee; Punyarit, Phaibul; Srisomsap, Chantragan; Svasti, Jisnuson

    2016-04-01

    Thyroid cancer is the most common human endocrine malignancy with increasing global incidence. Papillary thyroid carcinomas (PTC) and follicular thyroid carcinomas (FTC) are well-differentiated thyroid cancers (WDTC) accounting for 95% of all thyroid cancer cases, with survival rates of almost 100% when diagnosed early. Since PTC and FTC have different modes of metastasis, they require different treatment strategies. Standard diagnosis by fine needle aspiration with cytopathological examination can be inaccurate in approximately 10-30% of all cases and difficult to definitively classify as WDTC. Currently, there is no single or panel of biomarkers available for thyroid cancer diagnosis and classification. This study identified novel biomarkers for thyroid cancer diagnosis and classification using proteomics, which may be translated into a biomarker panel for clinical application. Two-dimensional SDS-PAGE and mass spectrometry were used to identify potential biomarkers in papillary and follicular thyroid carcinoma cell lines, and the biomarkers were validated in five PTC and five FTC tissues, with their adjacent normal tissues from Thai patients. Eight biomarkers could distinguish PTC from normal tissues, namely enolase 1, triose phosphate isomerase, cathepsin D, annexin A2, cofilin 1, proliferating cell nuclear antigen (PCNA), copine 1 and heat shock protein 27 kDa (HSP27). These biomarkers can also discriminate FTC from normal tissues, except for annexin A2. On the contrary, annexin A2, cofilin 1, PCNA and HSP27 can be used to classify the types of WDTC. These findings have potential for use as a novel multi-marker panel for more accurate diagnosis and classification to better guide physicians on thyroid cancer treatment. Moreover, our results suggest the involvement of proteins in cell growth and proliferation, and the p53 pathway in the carcinogenesis of WDTC, which may lead to targeted therapy for thyroid cancer. PMID:26782318

  2. 76 FR 44378 - Policy Statement of the U.S. Nuclear Regulatory Commission on the Protection of Cesium-137...

    Science.gov (United States)

    2011-07-25

    ... as immunology, hematology, stem cell research, bone marrow transplantation, cancer research, in-vivo... medical research. To develop its draft policy statement, the NRC initiated and completed a number of... Register on July 31, 2008 (73 FR 44780), and discussed with stakeholders in a public workshop held...

  3. 75 FR 37483 - Request for Comments on the Draft Policy Statement on the Protection of Cesium-137 Chloride...

    Science.gov (United States)

    2010-06-29

    ... biomedical research, CsCl irradiation has been used for over 40 years in fields such as immunology, stem cell research, cancer research, in-vivo immunology, systemic drug research, chromosome aberrations, DNA damage... devices for biological and medical research. To develop its draft policy statement, the NRC initiated...

  4. Statement on a conceptual framework for the risk assessment of certain food additives re-evaluated under Commission Regulation (EU) No 257/2010

    OpenAIRE

    EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)

    2014-01-01

    The Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific statement presenting a conceptual framework for the risk assessment of certain food additives re-evaluated under Commission Regulation (EU) No 257/2010. This framework will be used in the evaluation made by the Panel, but the expert judgement of the scientific background, on a case-by-case basis, remains essential to reach a final conclusion. The outcome of the re-evaluation of food additives taking int...

  5. BELTracker: evidence sentence retrieval for BEL statements.

    Science.gov (United States)

    Rastegar-Mojarad, Majid; Komandur Elayavilli, Ravikumar; Liu, Hongfang

    2016-01-01

    Biological expression language (BEL) is one of the main formal representation models of biological networks. The primary source of information for curating biological networks in BEL representation has been literature. It remains a challenge to identify relevant articles and the corresponding evidence statements for curating and validating BEL statements. In this paper, we describe BELTracker, a tool used to retrieve and rank evidence sentences from PubMed abstracts and full-text articles for a given BEL statement (per the 2015 task requirements of BioCreative V BEL Task). The system is comprised of three main components, (i) translation of a given BEL statement to an information retrieval (IR) query, (ii) retrieval of relevant PubMed citations and (iii) finding and ranking the evidence sentences in those citations. BELTracker uses a combination of multiple approaches based on traditional IR, machine learning, and heuristics to accomplish the task. The system identified and ranked at least one fully relevant evidence sentence in the top 10 retrieved sentences for 72 out of 97 BEL statements in the test set. BELTracker achieved a precision of 0.392, 0.532 and 0.615 when evaluated with three criteria, namely full, relaxed and context criteria, respectively, by the task organizers. Our team at Mayo Clinic was the only participant in this task. BELTracker is available as a RESTful API and is available for public use.Database URL: http://www.openbionlp.org:8080/BelTracker/finder/Given_BEL_Statement. PMID:27173525

  6. PERBANDINGAN UNJUK KERJA ANTARA PANEL SEL SURYA BERPENJEJAK DENGAN PANEL SEL SURYA DIAM

    OpenAIRE

    Syafaruddin Ch

    2010-01-01

    The ability to produce electrical energy at Solar Power Plant  is highly dependent on the magnitude and duration of sun exposure on the solar cell panels. The movement of the sun from east to west that periodicity in every day is a problem at  the  optimization generation of electricity at  Solar Power Plant   if using solar panel that motionless. This is because the solar cell panel can not catch the maximum sun exposure. To solve the above problem then designed a solar cell panel  tracker...

  7. Expanding disease definitions in guidelines and expert panel ties to industry: a cross-sectional study of common conditions in the United States.

    OpenAIRE

    Moynihan, Raymond N.; Cooke, Georga P. E.; Doust, Jenny A; Lisa Bero; Suzanne Hill; Glasziou, Paul P.

    2013-01-01

    Editors' Summary Background Health professionals generally base their diagnosis of physical and mental disorders among their patients on disease definitions and diagnostic thresholds that are drawn up by expert panels and published as statements or as part of clinical practice guidelines. These disease definitions and diagnostic thresholds are reviewed and updated in response to changes in disease detection methods, treatments, medical knowledge, and, in the case of mental illness, changes in...

  8. Nuclear safety policy statement in korea

    International Nuclear Information System (INIS)

    Full text: Wide varieties of programs to enhance nuclear safety have been established and implemented by the Korean government in accordance with the Nuclear Safety Policy Statement announced in September 1994. The policy statement was intended to set the long-term policy goals for maintaining and achieving high-level of nuclear safety and also help the public understand the national policy and a strong will of the government toward nuclear safety. It has been recognized as very effective in developing safety culture in nuclear-related organizations and also enhancing nuclear safety in Korea. However, ageing of operating nuclear power plants and increasing of new nuclear facilities have demanded a new comprehensive national safety policy to cover the coming decade, taking the implementation results of the policy statement of 1994 and the changing environment of nuclear industries into consideration. Therefore, the results of safety policy implementation have been reviewed and, considering changing environment and future prospects, a new nuclear safety policy statement as a highest level national policy has been developed. The implementation results of 11 regulatory policy directions such as the use of Probabilistic Safety Assessment, introduction of Periodic Safety Review, strengthening of safety research, introduction of Risk Based Regulation stipulated in the safety policy statement of 1994 were reviewed and measures taken after various symposia on nuclear safety held in Nuclear Safety Days since 1995 were evaluated. The changing international and domestic environment of nuclear industry were analysed and future prospects were explored. Based on the analysis and review results, a draft of new nuclear safety policy statement was developed. The draft was finalized after the review of many prominent experts in Korea. Considering changing environment and future prospects, new policy statement that will show government's persistent will for nuclear safety has been

  9. Monitoring of degradation of photovoltaic panels using infrared method

    International Nuclear Information System (INIS)

    Monitoring of solar panels is important in order to ensure optimal performance of solar panels. Their properties are subject to change due to aging, weather effects and exposure to environment. Infrared camera provides monitoring of degradation of solar panels. Similarly, thermal camera can detect errors in panels, which occurred during production or assembly. (authors)

  10. ESGAR consensus statement on liver MR imaging and clinical use of liver-specific contrast agents

    International Nuclear Information System (INIS)

    To develop a consensus and provide updated recommendations on liver MR imaging and the clinical use of liver-specific contrast agents. The European Society of Gastrointestinal and Abdominal Radiology (ESGAR) formed a multinational European panel of experts, selected on the basis of a literature review and their leadership in the field of liver MR imaging. A modified Delphi process was adopted to draft a list of statements. Descriptive and Cronbach's statistics were used to rate levels of agreement and internal reliability of the consensus. Three Delphi rounds were conducted and 76 statements composed on MR technique (n = 17), clinical application of liver-specific contrast agents in benign, focal liver lesions (n = 7), malignant liver lesions in non-cirrhotic (n = 9) and in cirrhotic patients (n = 18), diffuse and vascular liver diseases (n = 12), and bile ducts (n = 13). The overall mean score of agreement was 4.84 (SD ±0.17). Full consensus was reached in 22 % of all statements in all working groups, with no full consensus reached on diffuse and vascular diseases. The consensus provided updated recommendations on the methodology, and clinical indications, of MRI with liver specific contrast agents in the study of liver diseases. (orig.)

  11. ESGAR consensus statement on liver MR imaging and clinical use of liver-specific contrast agents

    Energy Technology Data Exchange (ETDEWEB)

    Neri, E.; Boraschi, P.; Bartolozzi, C. [University of Pisa, Department of Diagnostic and Interventional Radiology, Pisa (Italy); Bali, M.A.; Matos, C. [Hopital Erasme, MRI Clinics, Department of Radiology, Bruxelles (Belgium); Ba-Ssalamah, A. [The General Hospital of the Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna (Austria); Brancatelli, G. [University of Palermo, Department of Radiology, Palermo (Italy); Alves, F.C. [University Hospital of Coimbra, Medical Imaging Department and Faculty of Medicine, Coimbra (Portugal); Grazioli, L. [Spedali Civili di Brescia, Department of Radiology, Brescia (Italy); Helmberger, T. [Academic Teaching Hospital of the Technical University, Department of Diagnostic and Interventional Radiology and Nuclear Medicine, Klinikum Bogenhausen, Munich (Germany); Lee, J.M. [Seoul National University College of Medicine, Division of Abdominal Imaging, Department of Radiology, Seoul (Korea, Republic of); Manfredi, R. [University of Verona, Department of Radiology, Verona (Italy); Marti-Bonmati, L. [Hospital Universitario y Politecnico La Fe, Area Clinica de Imagen Medica, Valencia (Spain); Merkle, E.M. [Universitaetsspital Basel, Klinik fuer Radiologie und Nuklearmedizin, Basel (Switzerland); Op De Beeck, B. [Antwerp University Hospital, Department of Radiology, Edegem (Belgium); Schima, W. [KH Goettlicher Heiland, Krankenhaus der Barmherzigen Schwestern and Sankt Josef-Krankenhaus, Department of Diagnostic and Interventional Radiology, Vienna (Austria); Skehan, S. [St Vincent' s University Hospital, Department of Radiology, Dublin (Ireland); Vilgrain, V. [Assistance Publique-Hopitaux de Paris, APHP, Hopital Beaujon, Radiology Department, Clichy, Paris (France); Zech, C. [Universitaetsspital Basel, Abteilungsleiter Interventionelle Radiologie, Klinik fuer Radiologie und Nuklearmedizin, Basel (Switzerland)

    2016-04-15

    To develop a consensus and provide updated recommendations on liver MR imaging and the clinical use of liver-specific contrast agents. The European Society of Gastrointestinal and Abdominal Radiology (ESGAR) formed a multinational European panel of experts, selected on the basis of a literature review and their leadership in the field of liver MR imaging. A modified Delphi process was adopted to draft a list of statements. Descriptive and Cronbach's statistics were used to rate levels of agreement and internal reliability of the consensus. Three Delphi rounds were conducted and 76 statements composed on MR technique (n = 17), clinical application of liver-specific contrast agents in benign, focal liver lesions (n = 7), malignant liver lesions in non-cirrhotic (n = 9) and in cirrhotic patients (n = 18), diffuse and vascular liver diseases (n = 12), and bile ducts (n = 13). The overall mean score of agreement was 4.84 (SD ±0.17). Full consensus was reached in 22 % of all statements in all working groups, with no full consensus reached on diffuse and vascular diseases. The consensus provided updated recommendations on the methodology, and clinical indications, of MRI with liver specific contrast agents in the study of liver diseases. (orig.)

  12. Facilitator--and Self-Directed Groups: A Statement-by-Statement Interaction Study

    Science.gov (United States)

    Conyne, Robert K.; Rapin, Lynn S.

    1977-01-01

    This study compared the effectiveness of facilitator-directed and self-directed personal growth group treatments toward inducing therapeutic verbal interaction. An interaction process analysis approach, the Hill Interaction Matrix (HIM) statement-by-statement system, was used to examine treatment differences. (Author)

  13. Documenting North Netherlandish 17th Century Panel Makers’ House Marks

    DEFF Research Database (Denmark)

    Wadum, Jørgen

    2014-01-01

    The need for a quality control of Antwerp oak panels for painters in 1617 became structured with detailed regulations imposing the panel makers to issue each of their panels with the maker’s personal house mark and upon approval by the dean of the panel makers’ he with a hot iron would brand each...... accepted panel with the Coat of Arms of Antwerp. This poster shall for the first time present arguments and documentation of a comparable practice of issuing panels with a personal house mark on panels produced in the Northern Netherlands. Especially one panel maker’s mark has been traced a sufficient...... present the different North Netherlandish house marks/brands, their design, size, and other characteristics, in chronological order as found on 17th century Netherlandish panels. This information will be presented in conjunction with frequently recorded saw-marks on the back of the panels in conjunction...

  14. Live What You Teach & Teach What You Live: Student Views on the Acceptability of Teachers’ Value-Related Statements about Sustainability and Climate Change

    Directory of Open Access Journals (Sweden)

    Gregor Torkar

    2013-01-01

    Full Text Available This paper presents the results of a survey among pre-service and inservice students of pre-school education and students of environmental sciences on the acceptability of value-laden statements made by their teachers on issues of sustainable development and climate change. Fifteen statements were provided, and students had to choose among the options »acceptable statement«, »unacceptable statement« and »cannot decide«. The questionnaire was completed by 139 students from two universities in Slovenia. The results show that the students expect their teachers to promote the principles of sustainable development. The majority of students considered any teacher’s statement that would cast doubt on the cause or the necessity to act against climate change to be unacceptable. Teacher’s statements emphasising global issues that have, or could have, a direct impact on developed countries (e.g. climate change received higher support than those global questions that more heavily impact underdeveloped or developing countries (e.g. poverty, child labour, access to natural resources. In the conclusion, it is emphasised that teachers should assist students in developing their own moralpositions on complex issues such as sustainable development and climate change. Structured discussion techniques, such as a panel discussion, forum and debate, should be regularly and carefully implemented into lectures at the university level.

  15. Management of adverse events associated with idelalisib treatment: expert panel opinion

    OpenAIRE

    Coutré, Steven E.; Barrientos, Jacqueline C.; Brown, Jennifer R.; de Vos, Sven; Furman, Richard R.; Keating, Michael J.; Li, Daniel; O’Brien, Susan M.; Pagel, John M.; Poleski, Martin H.; Sharman, Jeff P.; Yao, Nai-Shun; Zelenetz, Andrew D.

    2015-01-01

    Idelalisib is a first-in-class selective, oral, phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor approved for the treatment of several types of blood cancer. Idelalisib has demonstrated significant efficacy and a tolerable safety profile in clinical trials. However, the US prescribing information contains a black box warning for fatal and/or severe diarrhea or colitis, hepatotoxicity, pneumonitis and intestinal perforation. An expert panel was convened to review the pathology of these tr...

  16. An Immunohistochemical Panel to Assess Ultraviolet Radiation Associated Oxidative Skin Injury

    OpenAIRE

    Mamalis, A; Fiadorchanka, N; L. ADAMS; Serravallo, M; Heilman, E; Siegel, D; Brody, N; Jagdeo, J

    2014-01-01

    Ultraviolet (UV) radiation results in a significant loss in years of healthy life, approximately 1.5 million disability-adjusted life years, and is associated with greater than 60,000 deaths annually worldwide that are attributed to melanoma and other skin cancers. Currently, there are no standardized biomarkers or assay panels to assess oxidative stress skin injury patterns in human skin exposed to ionizing radiation. Using biopsy specimens from chronic solar UV-exposed and UV-protected skin...

  17. How Far Do We Go With Genetic Evaluation? Gene, Panel, and Tumor Testing.

    Science.gov (United States)

    Lynce, Filipa; Isaacs, Claudine

    2016-01-01

    The traditional model by which an individual was identified as harboring a hereditary susceptibility to cancer was to test for a mutation in a single gene or a finite number of genes associated with a particular syndrome (e.g., BRCA1 and BRCA2 for hereditary breast and ovarian cancer or mismatch repair genes for Lynch syndrome). The decision regarding which gene or genes to test for was based on a review of the patient's personal medical history and their family history. With advances in next-generation DNA sequencing technology, offering simultaneous testing for multiple genes associated with a hereditary susceptibility to cancer is now possible. These panels typically include high-penetrance genes, but they also often include moderate- and low-penetrance genes. A number of the genes included in these panels have not been fully characterized either in terms of their cancer risks or their management options. Another way some patients are unexpectedly identified as carrying a germline mutation in a cancer susceptibility gene is at the time they undergo molecular profiling of their tumor, which typically has been carried out to guide treatment choices for their cancer. This article first focuses on the issues that need to be considered when deciding between recommending more targeted testing of a single or a small number of genes associated with a particular syndrome (single/limited gene testing) versus performing a multigene panel. This article also reviews the issues regarding germline risk that occur within the setting of ordering molecular profiling of tumors. PMID:27249773

  18. Statement complementing the scientific opinion on application EFSA-GMO-NL-2010-78 to cover the safety of soybean MON 87705 oil for commercial frying

    OpenAIRE

    EFSA Panel on Genetically Modified Organisms (GMO)

    2013-01-01

    In this statement, the EFSA GMO Panel responds to a request from the European Commission (EC) to assess the safety of soybean MON 87705 oil for commercial frying. The applicant provided exposure assessments based on total and partial substitutions of conventional soybean, rapeseed and sunflower oils with the soybean MON 87705 oil in foods (salad dressings, margarines and spreads, mayonnaise, crackers and salty snacks and soybean/rapeseed/sunflower oils processed foods). No distinction was mad...

  19. 5 CFR 2471.1 - Request for Panel consideration; request for Panel approval of binding arbitration.

    Science.gov (United States)

    2010-01-01

    ... for Panel approval of binding arbitration. 2471.1 Section 2471.1 Administrative Personnel FEDERAL... consideration; request for Panel approval of binding arbitration. If voluntary arrangements, including the... procedure, which they have agreed to adopt, for binding arbitration of the negotiation impasse by filing...

  20. Automatic Outdoor Monitoring System for Photovoltaic Panels

    Energy Technology Data Exchange (ETDEWEB)

    Stefancich, Marco; Simpson, Lin; Chiesa, Matteo

    2016-05-01

    Long-term acquisition of solar panel performance parameters, for panels operated at maximum power point in their real environment, is of critical importance in the photovoltaic research sector. However, few options exist for the characterization of non-standard panels such as concentrated photovoltaic systems, heavily soiled or shaded panels or those operating under non-standard spectral illumination; certainly, it is difficult to find such a measurement system that is flexible and affordable enough to be adopted by the smaller research institutes or universities. We present here an instrument aiming to fill this gap, autonomously tracking and maintaining any solar panel at maximum power point while continuously monitoring its operational parameters and dissipating the produced energy without connection to the power grid. The instrument allows periodic acquisition of current-voltage curves to verify the employed maximum power point tracking approach. At the same time, with hardware schematics and software code being provided, it provides a flexible open development environment for the monitoring of non-standard generators like concentrator photovoltaic systems and to test novel power tracking approaches. The key issues, and the corresponding solutions, encountered in the design are analyzed in detail and the relevant schematics presented.

  1. Design scenarios for flat panel photobioreactors

    International Nuclear Information System (INIS)

    Evaluation of the potential of algae production for biofuel and other products at various locations throughout the world requires assessment of algae productivity under varying light conditions and different reactor layouts. A model was developed to predict algae biomass production in flat panel photobioreactors using the interaction between light and algae growth for the algae species Phaeodactylum tricornutum and Thalassiosira pseudonana. The effect of location, variable sunlight and reactor layout on biomass production in single standing and parallel positioned flat panels was considered. Three latitudes were studied representing the Netherlands, France and Algeria. In single standing reactors the highest yearly biomass production is achieved in Algeria. During the year biomass production fluctuates the most in the Netherlands, while it is almost constant in Algeria. Several combinations of path lengths and biomass concentrations can result in the same optimal biomass production. The productivity in parallel place flat panels is strongly influenced by shading and diffuse light penetration between the panels. Panel orientation has a large effect on productivity and at higher latitudes the difference between north-south and east-west orientation may go up to 50%.

  2. Automatic outdoor monitoring system for photovoltaic panels

    Science.gov (United States)

    Stefancich, Marco; Simpson, Lin; Chiesa, Matteo

    2016-05-01

    Long-term acquisition of solar panel performance parameters, for panels operated at maximum power point in their real environment, is of critical importance in the photovoltaic research sector. However, few options exist for the characterization of non-standard panels such as concentrated photovoltaic systems, heavily soiled or shaded panels or those operating under non-standard spectral illumination; certainly, it is difficult to find such a measurement system that is flexible and affordable enough to be adopted by the smaller research institutes or universities. We present here an instrument aiming to fill this gap, autonomously tracking and maintaining any solar panel at maximum power point while continuously monitoring its operational parameters and dissipating the produced energy without connection to the power grid. The instrument allows periodic acquisition of current-voltage curves to verify the employed maximum power point tracking approach. At the same time, with hardware schematics and software code being provided, it provides a flexible open development environment for the monitoring of non-standard generators like concentrator photovoltaic systems and to test novel power tracking approaches. The key issues, and the corresponding solutions, encountered in the design are analyzed in detail and the relevant schematics presented.

  3. The Remarkable Staying Power of "Death Panels".

    Science.gov (United States)

    Frankford, David M

    2015-10-01

    Sarah Palin's phrase "death panels" derailed proposed provisions of the Affordable Care Act (ACA) to pay physicians for end-of-life discussions with patients, a policy designed to make dying more humane, something all Americans desire. Even now, "death panels" has truth-value for approximately half of Americans and is used to paint ACA components as threatening to "pull the plug on Grandma." How can this be? To some, the death panels claim is simply a lie, an improvised explosive device hurled against any ACA provision. To others, the phrase's power stems from the public's lack of a common vocabulary to discuss end-of-life care. "Death panels," however, taps into many Americans' fear of government involvement, that government's purchasing end-of-life discussions as commodities necessitates accountability and cost control. Standardization and reduction of humanity follows, something Americans already experience routinely in their health care system. Expert jargon, compelling among experts themselves, doesn't evoke people's images of chats with Marcus Welby. The jargon is unintelligible, off-putting. When that jargon enters the nonjargonized world, it mixes with common fears, extant experience of dehumanization and reduction, and awareness that someone's plug is getting pulled all the time. "Death panels" cannot be dismissed as delusional, but neither can it help fulfill Americans' aspirations for a humane last voyage. PMID:26195604

  4. Analysing sensory panel performance in a proficiency test using the PanelCheck software

    DEFF Research Database (Denmark)

    Tomic, O.; Luciano, G.; Nilsen, A.;

    2010-01-01

    This paper discusses statistical methods and a workflow strategy for comparing performance across multiple sensory panels that participated in a proficiency test (also referred to as inter laboratory test). Performance comparison and analysis are based on a data set collected from 26 sensory panels......Check software, a workflow is proposed that guides the user through the data analysis process. This allows practitioners and non-statisticians to get an overview over panel performances in a rapid manner without the need to be familiar with details on the statistical methods. Visualisation of data analysis...... results plays an important role as this provides a time saving and efficient way of screening and investigating sensory panel performances. Most of the statistical methods used in this paper are available in the open source software PanelCheck, which may be downloaded and used for free....

  5. DEGRO practical guidelines. Radiotherapy of breast cancer I. Radiotherapy following breast conserving therapy for invasive breast cancer

    International Nuclear Information System (INIS)

    Background and purpose: The aim of the present paper is to update the practical guidelines for postoperative adjuvant radiotherapy of breast cancer published in 2007 by the breast cancer expert panel of the German Society for Radiooncology (Deutsche Gesellschaft fuer Radioonkologie, DEGRO). The present recommendations are based on a revision of the German interdisciplinary S-3 guidelines published in July 2012. Methods: A comprehensive survey of the literature concerning radiotherapy following breast conserving therapy (BCT) was performed using the search terms 'breast cancer', 'radiotherapy', and 'breast conserving therapy'. Data from lately published meta-analyses, recent randomized trials, and guidelines of international breast cancer societies, yielding new aspects compared to 2007, provided the basis for defining recommendations according to the criteria of evidence-based medicine. In addition to the more general statements of the DKG (Deutsche Krebsgesellschaft), this paper addresses indications, target definition, dosage, and technique of radiotherapy of the breast after conservative surgery for invasive breast cancer. Results: Among numerous reports on the effect of radiotherapy during BCT published since the last recommendations, the recent EBCTCG report builds the largest meta-analysis so far available. In a 15 year follow-up on 10,801 patients, whole breast irradiation (WBI) halves the average annual rate of disease recurrence (RR 0.52, 0.48-0.56) and reduces the annual breast cancer death rate by about one sixth (RR 0.82, 0.75-0.90), with a similar proportional, but different absolute benefit in prognostic subgroups (EBCTCG 2011). Furthermore, there is growing evidence that risk-adapted dose augmentation strategies to the tumor bed as well as the implementation of high precision RT techniques (e.g., intraoperative radiotherapy) contribute substantially to a further reduction of local relapse rates. A main focus of ongoing research lies in partial breast

  6. DEGRO practical guidelines. Radiotherapy of breast cancer I. Radiotherapy following breast conserving therapy for invasive breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Sedlmayer, F. [Paracelsus Medical Univ. Hospital, Salzburg (Austria). Dept. of Radiotherapy and Radiation Oncology; Sautter-Bihl, M.L. [Staedtisches Klinium Karlsruhe (Germany). Klinik fuer Radioonkologie und Strahlentherapie; Budach, W. [University Hospital Duesseldorf (Germany)] [and others

    2013-10-15

    Background and purpose: The aim of the present paper is to update the practical guidelines for postoperative adjuvant radiotherapy of breast cancer published in 2007 by the breast cancer expert panel of the German Society for Radiooncology (Deutsche Gesellschaft fuer Radioonkologie, DEGRO). The present recommendations are based on a revision of the German interdisciplinary S-3 guidelines published in July 2012. Methods: A comprehensive survey of the literature concerning radiotherapy following breast conserving therapy (BCT) was performed using the search terms 'breast cancer', 'radiotherapy', and 'breast conserving therapy'. Data from lately published meta-analyses, recent randomized trials, and guidelines of international breast cancer societies, yielding new aspects compared to 2007, provided the basis for defining recommendations according to the criteria of evidence-based medicine. In addition to the more general statements of the DKG (Deutsche Krebsgesellschaft), this paper addresses indications, target definition, dosage, and technique of radiotherapy of the breast after conservative surgery for invasive breast cancer. Results: Among numerous reports on the effect of radiotherapy during BCT published since the last recommendations, the recent EBCTCG report builds the largest meta-analysis so far available. In a 15 year follow-up on 10,801 patients, whole breast irradiation (WBI) halves the average annual rate of disease recurrence (RR 0.52, 0.48-0.56) and reduces the annual breast cancer death rate by about one sixth (RR 0.82, 0.75-0.90), with a similar proportional, but different absolute benefit in prognostic subgroups (EBCTCG 2011). Furthermore, there is growing evidence that risk-adapted dose augmentation strategies to the tumor bed as well as the implementation of high precision RT techniques (e.g., intraoperative radiotherapy) contribute substantially to a further reduction of local relapse rates. A main focus of ongoing

  7. Mortality in cases of asbestosis diagnosed by a pneumoconiosis medical panel.

    OpenAIRE

    Coutts, I I; Gilson, J C; Kerr, I H; Parkes, W R; Turner-Warwick, M

    1987-01-01

    One hundred and fifty five male cases of asbestosis certified by the London Pneumoconiosis Medical Panel during 1968-74 were followed up during 1978-9, 4-11 (mean 7.5) years after certification. Fifty nine patients had died, 23 (39%) from lung cancer, 6 (10%) from mesothelioma, and 11 (19%) from other respiratory causes. The number of observed deaths was 2.25 times greater than expected and 7.4 times greater than expected for lung cancer. Adenocarcinoma was the commonest histological type but...

  8. Change Point in Panel Data with Small Fixed Panel Size: Ratio and Non-Ratio Test Statistics

    OpenAIRE

    Peštová, Barbora; Pešta, Michal

    2016-01-01

    The main goal is to develop and, consequently, compare stochastic methods for detection whether a structural change in panel data occurred at some unknown time or not. Panel data of our interest consist of a moderate or relatively large number of panels, while the panels contain a small number of observations. Testing procedures to detect a possible common change in means of the panels are established. Ratio and non-ratio type test statistics are considered. Their asymptotic distributions und...

  9. Final environmental statement for the geothermal leasing program

    Energy Technology Data Exchange (ETDEWEB)

    1973-12-31

    This second of the four volumes of the Geothermal Leasing Program final impact statement contains the individual environmental statements for the leasing of federally owned geothermal resources for development in three specific areas: Clear Lake-Geysers; Mono Lake-Long Valley; and Imperial Valley, all in California. It also includes a summary of the written comments received and departmental responses relative to the Draft Environmental Impact Statement issued in 1971; comments and responses on the Draft Environmental Impact Statement; consultation and coordination in the development of the proposal and in the preparation of the Draft Environmental Statement; and coordination in the review of the Draft Environmental Statement.

  10. Underwater Explosion Damage of Ship Hull Panels

    Directory of Open Access Journals (Sweden)

    K. Rarnajeyathilagam

    2003-10-01

    Full Text Available Underwater explosion is a major threat to ships and submarines in a war environment. The prediction of the mode and the extent of the failure is an essential step in designing for shock loading. The localised failure in a hull panel is severe compared to the global response of the ship. In this study, an attempt has been made to predict the response and failure modes of three types of hull panels (flat, concave, and convex. The shock loading on the hull panel has been estimated based on the Taylor's plate theory. The numerical analysis has been carried out using the CSAIGENSA (DYNA3D code that employs nonlinear finite element model.

  11. Perturbed panel flutter : a simple model

    International Nuclear Information System (INIS)

    The effects of small periodic disturbances on the response of a two-degree-of-freedom, non-conservative, mechanical system are analyzed. The system is a simple model for panel flutter. The disturbance simulates the pressure fluctuations of a turbulent boundary layer on the panel. Asymptotic expansions of the solutions are obtained for small amplitude disturbances. The qualitative features of the response depend on the prescribed variation of the disrurbance frequency with the magnitude of the non-conservative applied force. The disturbance can induce a smooth transition to the fluttering states of the rods; or it may induce jump transitions. The results suggest a possible technique for delaying panel flutter, by applying periodic forcing functions with appropriate frequencies. (Author)

  12. Utilization of Bamboo as Lightweight Sandwich Panels

    Directory of Open Access Journals (Sweden)

    Suthon SRIVARO

    2016-05-01

    Full Text Available Lightweight sandwich panels consisting of bamboo faces and oil palm trunk core were manufactured using melamine urea formaldehyde with the resin content of 250 g/m2 (solid basis. The parameters examined were node and density of bamboo faces. Physical (board density, thickness swelling and water absorption and mechanical (modulus of elasticity and modulus of rupture properties of the sandwich board obtained were investigated and compared with other bamboo products and commercial wood based products. Result showed that this panel had better dimensional stability than those of other bamboo products but lower bending strength. Node of bamboo had no significant effect on any board properties examined. Most of board properties were influenced by bamboo face density. Comparing the properties to commercial wood based products, this panel could be used as wall/floor applications.

  13. Thin Film Photovoltaic/Thermal Solar Panels

    Institute of Scientific and Technical Information of China (English)

    David JOHNSTON

    2008-01-01

    A solar panel is described.in which thin films of semiconductor are deposited onto a metal substrate.The semiconductor-metal combination forms a thin film photovoltaic cell,and also acts as a reflector,absorber tandem, which acts as a solar selective surface,thus enhancing the solar thermal performance of the collector plate.The use of thin films reduces the distance heat is required to flow from the absorbing surface to the metal plate and heat exchange conduits.Computer modelling demonstrated that,by suitable choice of materials,photovohaic efficiency call be maintained,with thermal performance slishtly reduced,compared to that for thermal-only panels.By grading the absorber layer-to reduce the band gap in the lower region-the thermal performance can be improved,approaching that for a thermal-only solar panel.

  14. Rivited panel surface measurement using photogrammetry

    Science.gov (United States)

    Merrick, W. D.; Lobb, V. B.; Lansing, F. L.; Stoller, F. W.

    1986-01-01

    Two riveted antenna panels on rings number 3 and 9 were removed from the 34m antenna at DSS-15, fixed in the leveled position and the surface was photographed indoors. The results from this pilot photogrammetric demonstration and diagnostics of panel surface contours, are presented. The photogrammetric network for each panel incorporated eight photographs, two from each of four camera stations and observed over 200 targets. The accuracy (1 sigma) of the XYZ coordinates for the error ellipsoids was + or - 0.013 mm (0.0005 inch). This level of precision relative to the object size corresponds roughly to 1 part in 250,000 which is superior to conventional dial sweep-arm template techniques by at least a factor of 4.

  15. APPLIED ORIGAMI. Origami of thick panels.

    Science.gov (United States)

    Chen, Yan; Peng, Rui; You, Zhong

    2015-07-24

    Origami patterns, including the rigid origami patterns in which flat inflexible sheets are joined by creases, are primarily created for zero-thickness sheets. In order to apply them to fold structures such as roofs, solar panels, and space mirrors, for which thickness cannot be disregarded, various methods have been suggested. However, they generally involve adding materials to or offsetting panels away from the idealized sheet without altering the kinematic model used to simulate folding. We develop a comprehensive kinematic synthesis for rigid origami of thick panels that differs from the existing kinematic model but is capable of reproducing motions identical to that of zero-thickness origami. The approach, proven to be effective for typical origami, can be readily applied to fold real engineering structures. PMID:26206928

  16. Multiscale Fatigue Life Prediction for Composite Panels

    Science.gov (United States)

    Bednarcyk, Brett A.; Yarrington, Phillip W.; Arnold, Steven M.

    2012-01-01

    Fatigue life prediction capabilities have been incorporated into the HyperSizer Composite Analysis and Structural Sizing Software. The fatigue damage model is introduced at the fiber/matrix constituent scale through HyperSizer s coupling with NASA s MAC/GMC micromechanics software. This enables prediction of the micro scale damage progression throughout stiffened and sandwich panels as a function of cycles leading ultimately to simulated panel failure. The fatigue model implementation uses a cycle jumping technique such that, rather than applying a specified number of additional cycles, a specified local damage increment is specified and the number of additional cycles to reach this damage increment is calculated. In this way, the effect of stress redistribution due to damage-induced stiffness change is captured, but the fatigue simulations remain computationally efficient. The model is compared to experimental fatigue life data for two composite facesheet/foam core sandwich panels, demonstrating very good agreement.

  17. Consensus statement on genetic research in dementia

    DEFF Research Database (Denmark)

    Rikkert, M.G. Olde; der, V van; Burns, A.;

    2008-01-01

    In this article, the authors describe how the European Dementia Consensus Network developed a consensus on research ethics in dementia, taking into account the questions posed by the era of genetic research and its new research methods. The consensus process started with a Delphi procedure to...... procedure fuelled the development of the consensus statement, which is presented in this paper. The consensus statement aims to stimulate ethically acceptable research in the field of dementia and the protection of vulnerable elderly patients with dementia from application of inadequate research methods or...... analyze relevant stakeholders' positions by describing their statements on the possibilities and limitations of research into genetic determinants of Alzheimer disease and to describe and analyze the moral desirability of genetic research on Alzheimer disease. The conclusions drawn from the Delphi...

  18. 78 FR 50064 - National Cancer Institute; Notice of Meeting

    Science.gov (United States)

    2013-08-16

    ...: 8:30 a.m. to 3:30 p.m. Agenda: Cancer Communication for Prevention: In the Digital Commons... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Meeting Pursuant to... a meeting of the President's Cancer Panel. The meeting will be open to the public, with...

  19. 78 FR 69432 - National Cancer Institute; Notice of Meeting

    Science.gov (United States)

    2013-11-19

    ...:30 a.m. to 4:00 p.m. Agenda: Cancer Communication in the Digital Era: Opportunities and Challenges... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Meeting Pursuant to... a meeting of the President's Cancer Panel. The meeting will be open to the public, with...

  20. 75 FR 16488 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-04-01

    ... the treatment of cancer. The outcome of the evaluation will provide information to internal NCI... development of the potential therapeutic to improve the treatment of various forms of cancer. The research... of Committee: National Cancer Institute Special Emphasis Panel; NCI Experimental Therapeutics...

  1. 75 FR 60132 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-09-29

    ... the treatment of cancer. The outcome of the evaluation will provide information to internal NCI... development of the potential therapeutic to improve the treatment of various forms of cancer. The research... of Committee: National Cancer Institute Special Emphasis Panel; NCI Experimental Therapeutics...

  2. 76 FR 42719 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-07-19

    ... the treatment of cancer. The outcome of the evaluation will provide information to internal NCI... development of the potential therapeutic to improve the treatment of various forms of cancer. The research... of Committee: National Cancer Institute Special Emphasis Panel, NCI Experimental Therapeutics...

  3. 77 FR 43098 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2012-07-23

    ... the treatment of cancer. The outcome of the evaluation will provide information to internal NCI... development of the potential therapeutic to improve the treatment of various forms of cancer. The research... of Committee: National Cancer Institute Special Emphasis Panel; NCI Experimental Therapeutics...

  4. 78 FR 53154 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-08-28

    ... Prevention Research; 93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93... Emphasis Panel NCI Experimental Therapeutics--Clinical Trials Network with Phase 1 Emphasis. Date: November... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  5. 76 FR 10381 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-02-24

    ... the treatment of cancer. The outcome of the evaluation will provide information to internal NCI... development of the potential therapeutic to improve the treatment of various forms of cancer. The research... of Committee: National Cancer Institute Special Emphasis Panel; NCI Experimental Therapeutics...

  6. 77 FR 15782 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2012-03-16

    ... the treatment of cancer. The outcome of the evaluation will provide information to internal NCI... development of the potential therapeutic to improve the treatment of various forms of cancer. The research.... ] Name of Committee: National Cancer Institute Special Emphasis Panel NCI Experimental...

  7. 75 FR 33817 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-06-15

    ... the treatment of cancer. The outcome of the evaluation will provide information to internal NCI... development of the potential therapeutic to improve the treatment of various forms of cancer. The research... of Committee: National Cancer Institute Special Emphasis Panel; NCI Experimental Therapeutics...

  8. 76 FR 66733 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-10-27

    ... the treatment of cancer. The outcome of the evaluation will provide information to internal NCI... development of the potential therapeutic to improve the treatment of various forms of cancer. The research... of Committee: National Cancer Institute Special Emphasis Panel, NCI Experimental Therapeutics...

  9. Fire Resistant Panels for the Tunnel Linings

    Directory of Open Access Journals (Sweden)

    Gravit Marina

    2016-01-01

    Full Text Available Presents the results of studies of innovative materials in the field of experimental and theoretical research fire resistance fireproof panels Pyro-Safe Aestuver T. Owing to the assembly simplicity, materials cheapness, high ecological standard, recycling, reuse potential, are benefit. Research work is running to improve the knowledge about fireproof panels Pyro-Safe Aestuver T for tunnel lining, its basic performance, its long term behavior and in particular also its fire proof for example when used for the lining of road tunnels.

  10. Pantex Falling Man - Independent Review Panel Report.

    Energy Technology Data Exchange (ETDEWEB)

    Brannon, Nathan Gregory; L. Bertolini, N. Brannon, J. Olsen, B. Price, M. Steinzig, R. Wardle, & M. Winfield

    2014-11-01

    Consolidated Nuclear Security (CNS) Pantex took the initiative to organize a Review Panel of subject matter experts to independently assess the adequacy of the Pantex Tripping Man Analysis methodology. The purpose of this report is to capture the details of the assessment including the scope, approach, results, and detailed Appendices. Along with the assessment of the analysis methodology, the panel evaluated the adequacy with which the methodology was applied as well as congruence with Department of Energy (DOE) standards 3009 and 3016. The approach included the review of relevant documentation, interactive discussion with Pantex staff, and the iterative process of evaluating critical lines of inquiry.

  11. Sustainable Absorption Panels from Agricultural Wastes

    Directory of Open Access Journals (Sweden)

    Ismail F.Z.

    2014-01-01

    Full Text Available Noise has become a serious environmental problem and there are demands for alternative sustainable materials which capable to reduce the noise level at various frequency ranges. Therefore, the aim of this research is to study the potential of turning the agricultural waste and waste paper into a sound absorption panel. For the purpose of this study, combination of two materials was under studied; coconut coir fibre from agriculture waste and shredded waste paper from the office. There were two main objective of the research; first is to develop absorption panels from coconut coir powder that available locally with a combination of shredded paper at different percentage of mixture. Second objective is to identify the absorption rate of the panels. The study encompasses the fabrication of the particle board using the coconut husk powder mix with shredded waste paper and using the gypsum powder as the binder for the two materials. Four acoustic panels of size 0.5m x 0.5m and 0.012 m thick were fabricated with different mix ratio; 25% of coconut coir powder mixed with 75% of shredded waste papers for sample 1, 50% both of the material for sample 2, 75% of coconut coir powder mixed with 25% of shredded waste paper for sample 3, and lastly 100% of coconut coir powder for sample 4. The absorption coefficient of the panels was tested in a reverberation chamber and in accordance with ISO 354:1985 standards. Based on the results, sample 1 gave the highest absorption coefficient compared to sample 2, 3 and 4. It can be concluded that the acoustic panel made from a mixture of 25% coconut coir powder with 75% shredded waste paper provided higher absorption coefficient compared to the performance of the other samples. This might be caused by the size of the coir powder which is very small, creating less void space in between the panel and thus causing it to absorb less sound. Since sound absorption is very much affected by the availability of void space of

  12. The Psoriatic Disease Payer Advisory Panel.

    Science.gov (United States)

    Greb, Jacqueline E; Merola, Joseph; Garg, Amit; Latella, John; Howard, Leah; Acharya, Nayan; Gottlieb, Alice B

    2016-05-01

    A collaborative exchange of ideas occurred at The Psoriatic Disease Payer Advisory Panel sponsored by International Dermatology Outcomes Measures (IDEOM) and The National Psoriasis Foundation (NPF) in January, 2016. Patient, provider, payer, pharmaceutical industry, IDEOM board member, and NPF leader representatives shared perspectives to address the unmet needs in the treatment of psoriatic patients. The payers who play a crucial role in controlling treatment access and improving patient outcomes played a pivotal role in the discussion. Progress made during the Payer Advisory Panel will ultimately advance psoriatic initiatives and help to address the persistent challenges of all vested stakeholders. J Drugs Dermatol. 2016;15(5):641-644. PMID:27168273

  13. Financial Statement Fraud Detection by Data Mining

    Directory of Open Access Journals (Sweden)

    G.Apparao

    2009-11-01

    Full Text Available Financial losses due to financial statement frauds (FSF are increasing day by day in the world. The industry recognizes the problem and is just now starting to act. Although prevention is the best way to reduce frauds, fraudsters are adaptive and will usually find ways to circumvent such measures. Detecting fraud is essential once prevention mechanism has failed. Several data mining algorithms have been developed that allow one to extract relevant knowledge from a large amount of data like fraudulent financial statements to detect FSF. It is an attempt to detect FSF ; We present a generic framework to do our analysis.

  14. The utility of Pro Forma Income Statements.

    Science.gov (United States)

    Reiboldt, Max; Reiboldt, John

    2002-01-01

    Recent headlines surrounding the financial demise of the nation's seventh largest company, Enron, and its subsequent entanglements with its accounting and consulting firm, Arthur Andersen, have placed a cloud of suspicion upon many reasonable business practices that otherwise are considered standard procedure. The proforma income statement is one of those practices. An oft-used tool in financial management, pro formas play a useful role for projecting financial performance based on predictable forecasts or assumptions. Regardless of the current scrutiny, there is still a valid use for accurately prepared statements. PMID:12389329

  15. Resource Contingency Program : Draft Environmental Impact Statement.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1995-02-01

    In 1990, the Bonneville Power Administration (BPA) embarked upon the Resource Contingency Program (RCP) to fulfill its statutory responsibilities to supply electrical power to its utility, industrial and other customers in the Pacific Northwest. Instead of buying or building generating plants now, BPA has purchased options to acquire power later if needed. Three option development agreements were signed in September 1993 with three proposed natural gas-fired, combined cycle combustion turbine CT projects near Chehalis and Satsop Washington and near Hermiston, Oregon. This environmental impact statement addresses the environmental consequences of purchasing power from these options. This environmental impact statement addresses the environmental consequences of purchasing power from these options.

  16. Malaysia (country/area statements).

    Science.gov (United States)

    1985-09-01

    According to this statement presented to the Committee on Population of the UN Economic and Social Commission for Asia and the Pacific, Malaysia by 1984 achieved a crude death rate of 5.3/1000, an infant mortality rate of 17/1000 live births, and a 1983 life expectancy at birth of 67.6 for males and 72.3 for females due primarily to socioeconomic development, better nutrition, and a health system covering 95% of the rural population. Substantial mortality differentials still exist between Peninsular Malaysia, Sabah, and Sarawak, between urban and rural areas, and among ethnic groups. Differences in the coverage and quality of mortality statistics also exist. 83.2% of Malaysia's total population of 15.5 million is in Peninsular Malaysia, 7.3% in Sabah, and 9.5% in Sarawak. In Peninsular Malaysia, 55.1% are Malays, 33.9% Chinese, and 10.3% Indians. About 40% of the population is urban, and 39% is under age 15. The average annual rate of growth declined from 2.6% in the 1960s to 2.3% in the 1970s. The total fertility rate fell from 5.1 children in 1970 to 4.1 in 1980. A rise in age at 1st marriage and reduction in marital fertility have been partly offset by an increase in the proportion of women of childbearing age. The population is projected to grow to about 22 million by the year 2000. Chinese and Indians are expected to approach replacement level fertility by that year, but Malay fertility is expected to remain high for some time. Internal migration, 45% of which is intrarural, increased markedly in the 1970s, probably due to rapid modernization, industrialization, land development, and regional imbalances in economic development. In absolute terms a total of 410,000 persons moved from rural to urban areas during the 1970s. Important progress has been made in regional development programs, but further regional development requires resolution of problems related to internal migration and greater efforts to relocate industries in the less developed areas. The

  17. Low frequency noise reduction using stiff light composite panels

    Institute of Scientific and Technical Information of China (English)

    DENG Yongchang; LIN Weizheng

    2003-01-01

    The experiment presented in this paper is to investigate and analyze the noise reduction at low frequency using stiff light composite panels. Since these composite panels are made of lightweight and stiff materials, this actuation strategy will enable the creation of composite panels for duct noise control without using traditional heavy structural mass. The results suggest that the mass-spring resonance absorption in the case of a comparatively stiff thick panel with a thin flexible plate is more efficient with minimum weight, when subjected to low-frequency (<500 Hz). The efficiency of the panel absorber depends on the mass of the thin flexible plate and the stiffness of the panel.

  18. Influence of plywood grain direction on sandwich panel bending properties

    OpenAIRE

    Jaroslav Kljak; Mladen Brezović; Alan Antonović

    2009-01-01

    This paper investigates the influence of plywood grain direction on bending properties of a sandwich panel, as well as on stress distribution in each layer. Experimental sandwich panels (tnom= 29 mm) were made of two three-ply plywood panels and a rigid PVC core between them. Grain directions of plywood panels were between 0° and 90°, continuously raised by 15°. Seven models of sandwich panels were made. Bending properties of a sandwich panel was determined by three point bending method and s...

  19. AAS Committee on Employment Panel Introduction

    Science.gov (United States)

    Borne, Kirk; Fanelli, M. N.; Storrie-Lombardi, L. J.; Krishnamurthi, A.

    2006-12-01

    Many younger astronomers are unaware of the dangers and pitfalls that await them in the job market. Issues related to fringe benefits (if any), moving expenses, medical coverage for family members, teaching versus research expectations, etc. can lead to misunderstandings and to serious difficulties if these are not addressed early in the job interview process. The AAS Committee on Employment has often received letters from concerned junior members of the society, who feel that they needed more guidance and assistance in entering the job market for the first time. The major areas of concern have included those just listed, but there may be others. The session is structured as a panel presentation, whose members are asked to prepare in advance their top 10 questions that job applicants should ask, and we will instruct our panel members not to discuss their list at all with the other panel members prior to their presentations. This will ensure independent viewpoints and novel responses. The panel will consist of astronomers who have different perspectives on this issue, including old and young, postdoc and beyond, academic and non-academic. To kick off the session, we will invite a brief humorous presentation of the Top Ten List, in the style of The Night Show host David Letterman.

  20. Testing weak exogeneity in cointegrated panels

    OpenAIRE

    Moral-Benito, Enrique; Serven, Luis

    2013-01-01

    For reason of empirical tractability, analysis of cointegrated economic time series is often developed in a partial setting, in which a subset of variables is explicitly modeled conditional on the rest. This approach yields valid inference only if the conditioning variables are weakly exogenous for the parameters of interest. This paper proposes a new test of weak exogeneity in panel coint...

  1. Use of informatics in radiation control panels

    International Nuclear Information System (INIS)

    Radiation control panels with programmed systems have developed at the CEA over the last few years. Each monitored location is provided with an monitoring station containing: - a radiation detector and associated electronics (the output signal is normalised calibrated pulses), - an alarm unit to warn personnal of any danger inside the detection zone covered

  2. Bivariate dynamic probit models for panel data

    OpenAIRE

    Alfonso Miranda

    2010-01-01

    In this talk, I will discuss the main methodological features of the bivariate dynamic probit model for panel data. I will present an example using simulated data, giving special emphasis to the initial conditions problem in dynamic models and the difference between true and spurious state dependence. The model is fit by maximum simulated likelihood.

  3. Design scenarios for flat panel photobioreactors

    NARCIS (Netherlands)

    Slegers, P.M.; Wijffels, R.H.; Straten, van G.; Boxtel, van A.J.B.

    2011-01-01

    Evaluation of the potential of algae production for biofuel and other products at various locations throughout the world requires assessment of algae productivity under varying light conditions and different reactor layouts. A model was developed to predict algae biomass production in flat panel pho

  4. Developing a solar panel testing system

    Directory of Open Access Journals (Sweden)

    Árpád Rácz

    2009-10-01

    Full Text Available Solar energy is increasingly used togenerate electricity for individual households. There isa wide variety of solar panel technologies, whichshould be tested at an individual level during theirlifetime. In this paper, the development of a testingstation at the University of Debrecen is presented. Thetesting system can be used for research andeducational purposes and for in field applicationsequally well.

  5. Photovoltaic panels, the waste of the future

    International Nuclear Information System (INIS)

    In use for some years now as alternative means of generating electricity, photovoltaic panels contain heavy metals, end-of-life management of which is already raising questions. The collection and treatment sector is beginning to structure itself by developing new processes, the impacts of which in terms of chemical risks remain to be defined. (author)

  6. New optical sensor panel on nanocomposite base

    Czech Academy of Sciences Publication Activity Database

    Panchenko, S.; Suleimenov, I.; Sedláková, Zdeňka; Semenyakin, N.

    Pfaffikon: Trans Tech Publications, 2014 - (Yu, L.; Xu, Q.), Roč. 1037, č. 2014, s. 20-25 ISSN 1022-6680. [International Conference on Computing, Control and Industrial Engineering /5./ - CCIE 2014. Wuhan (CN), 25.10.2014-26.10.2014] Institutional support: RVO:61389013 Keywords : optical sensor panel * nanocomposite * total internal reflection Subject RIV: CD - Macromolecular Chemistry

  7. Robust control investigations for equipment loaded panels

    DEFF Research Database (Denmark)

    Aglietti, G.S.; Langley, R.S.; Rogers, E.;

    1998-01-01

    This paper develops a modelling technique for equipment load panels which directly produces (adequate) models of the underlying dynamics on which to base robust controller design/evaluations. This technique is based on the use of the Lagrange's equations of motion and the resulting models are...

  8. Panel Discussion - Eastern and Central Europe decommissioning

    International Nuclear Information System (INIS)

    In conjunction with technical session 'Experience with Present Decommissioning Projects' the Panel Discussion is organized in the frame of ECED 2013 Conference. The main purposes of the panel was to analyse more in details the information given in the previous session and mainly to answer the questions from the audience. The panel was focused on the on-going decommissioning projects and on the projects in the final phase of preparation in the region of Eastern and Central Europe as follows: - Ignalina Nuclear Power Plant in Lithuania - RBMK-1500 reactors; - Chernobyl Nuclear Power Plant in Ukraine - RBMK-1000 reactors; - Kozloduy Nuclear Power Plant in Bulgaria - VVER-440 reactors; - Metsamor Armenian Nuclear Power Plant - VVER-440 reactors; - Greifswald Nuclear Power Plant in Germany (former East Germany) - VVER-440 reactors; - V1 Nuclear Power Plant in Slovakia - VVER-440 reactors; - A1 Nuclear Power Plant in Slovakia - Heavy Water Gas Cooled Reactor; shutdown after accident. The panel speakers listed the skilled and experienced representatives from all above mentioned countries and from Russian Federation where many decommissioning projects are ongoing or under preparation. The region of Eastern and Central Europe has actually become very important in the field of decommissioning and the lessons learned from the performed projects could make a significant base for decommissioning projects worldwide.

  9. Absorptive coating for aluminum solar panels

    Science.gov (United States)

    Desmet, D.; Jason, A.; Parr, A.

    1979-01-01

    Method for coating forming coating of copper oxide from copper component of sheet aluminum/copper alloy provides strong durable solar heat collector panels. Copper oxide coating has solar absorption characteristics similar to black chrome and is much simpler and less costly to produce.

  10. Damage tolerance analysis of aircraft reinforced panels

    Directory of Open Access Journals (Sweden)

    A. Pirondi

    2011-04-01

    Full Text Available This work is aimed at reproducing numerically a campaign of experimental tests performed for the development of reinforced panels, typically found in aircraft fuselage. The bonded reinforcements can significantly reduce the rate of fatigue crack growth and increase the residual strength of the skin. The reinforcements are of two types: stringers and doublers. The former provides stiffening to the panel while the latter controls the crack growth between the stringers. The purpose of the study is to validate a numerical method of analysis that can predict the damage tolerance of these reinforced panels. Therefore, using a fracture mechanics approach, several models (different by the geometry and the types of reinforcement constraints were simulated with the finite element solver ABAQUS. The bonding between skin and stiffener was taken either rigid or flexible due to the presence of adhesive. The possible rupture of the reinforcements was also considered. The stress intensity factor trend obtained numerically as a function of crack growth was used to determine the fatigue crack growth rate, obtaining a good approximation of the experimental crack propagation rate in the skin. Therefore, different solutions for improving the damage tolerance of aircraft reinforced panels can be virtually tested in this way before performing experiments.

  11. Compressive Strength of Longitudinally Stiffened GRP Panels

    DEFF Research Database (Denmark)

    Böhme, J.; Noury, P.; Riber, Hans Jørgen;

    1996-01-01

    A structural analysis of a cross stiffened orthotropic GRP panel subjected to uniaxial compressive loads is carried out. Analytical solutions to the buckling of such structures are proposed and validated by a finite element analysis. Both analytical and finite element approaches confirm an identi...

  12. Identification of Macroeconomic Factors in Large Panels

    DEFF Research Database (Denmark)

    Bork, Lasse; Dewachter, Hans; Houssa, Romain

    standard practices in the SVAR literature. Estimators based on the EM algorithm are developped. We apply this framework to a large panel of US monthly macroeconomic series. In particular, we identify nine macroeconomic factors and discuss the economic impact of monetary policy stocks. The results...

  13. 78 FR 42554 - Meetings of Humanities Panel

    Science.gov (United States)

    2013-07-16

    ... August 2013 as follows. The purpose of the meetings is for panel review, discussion, evaluation, and... Teachers grant program on the subjects of Music and Dance, submitted to the Division of Research Programs... include review of personal and/or proprietary ] financial and commercial information given in...

  14. Heavy water lattices: Second panel report

    International Nuclear Information System (INIS)

    The panel was attended by prominent physicists from most of the laboratories engaged in the field of heavy water lattices throughout the world. The participants presented written contributions and status reports describing the past history and plans for further development of heavy-water reactors. Valuable discussions took place, during which recommendations for future work were formulated. Refs, figs, tabs

  15. 77 FR 13154 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2012-03-05

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice--meeting. Pursuant to Section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92-463), as amended, notice is hereby given that a meeting of the...

  16. 77 FR 2766 - Arts Advisory Panel Meeting

    Science.gov (United States)

    2012-01-19

    ... ARTS AND THE HUMANITIES Arts Advisory Panel Meeting AGENCY: National Endowment for the Arts, National Foundation on the Arts and Humanities. ACTION: Notice; correction. SUMMARY: Pursuant to Section 10(a)(2) of... Arts (state folk arts projects review) meeting, scheduled for January 19-20, 2012 in Room 714....

  17. Blood Test: Comprehensive Metabolic Panel (CMP)

    Science.gov (United States)

    ... KidsHealth in the Classroom What Other Parents Are Reading Zika & Pregnancy: What to Know Signing Kids Up for Sports Pregnant? Your Baby's Growth Cerebral Palsy: Caring for Your Child All About Food Allergies Blood Test: Comprehensive Metabolic Panel (CMP) KidsHealth > For Parents > Blood Test: ...

  18. The thesis statement in translations of academic discourse

    OpenAIRE

    Pisanski Peterlin, Agnes

    2015-01-01

    Research has shown that languages exhibit substantial differences in the conventions of academic discourse. The thesis statement has been identified asone of the conventions in which differences between languages have been observed. This paper analyses thesis-statement use and form in a corpus of 90 geography research articles: Slovene originals, their English translations, and English originals are compared in terms of thesis-statement use and form. The results show that the thesis statement...

  19. Urine Diagnosis for Cancer

    Institute of Scientific and Technical Information of China (English)

    Guo Haiyan; Zhao Baohua

    2002-01-01

    @@ The key to saving the life of a person suffering from a malignant tumor lies in early diagnosis and surgery. Chinese scientists have developed a new method of diagnosing cancer by analyzing a person's urine. This feat was acclaimed by a panel of experts at a meeting under the auspices of the Chinese Academy of Sciences (CAS) in July 30 in Dalian, in northeast China's Liaoning Province.

  20. Politics Between Economy and Culture. Introductory Statement.

    Science.gov (United States)

    Rokkan, Stein

    The introductory statement to the plenary session of the Ninth World Congress of the International Political Science Association announces the first of two major themes, politics between economy and culture. This theme is described as investigating the culture-economy dialectic at all levels of politics -- global, territorial, national, community,…