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Sample records for ca 15-3 como

  1. Bone scan and serum CA 15-3 in bone metastasis in breast cancer

    International Nuclear Information System (INIS)

    Mendoza, G.; Cano, R.; Morales, R.; Guzman, C.

    1996-01-01

    CA 15-3 is a tumor marker useful in evolution control of breast cancer, being the serum levels trend the most important parameter. The purpose of this study was to report our experience and show the concordance of bone scan and CA 15-3 in patients with breast cancer attending the Breast and Bone Department of INEN from June to December 1993. One hundred patients had serum CA 15-3 quantification between June and December of 1993 in Nuclear Medicine Center (Peruvian Institute of Nuclear Energy and National Institute of Neoplasic Diseases). We selected 52 patients which simultaneously had a bone scan performed. Patients age ranged from 21 to 67 years (media of 44,57 years). 99m Tc methylenediphosphonate produced by IPEN was the radiopharmaceutical employed. A GE AZS-400 gamma camera was utilized to obtain the bone scans. Ca 15-5 quantification was performed with ELSA-CA 15-3 (CIS bio France) IRMA kit. Bone scan and CA 15-3 media of 17,06 U/ml (DS 15,4). Eight patients had a positive bone scan with a CA 15-3 media of 41,6 U/ml (SD 23,0). CA 15-3 levels ranged between 4,6 and 96,0 U/ml in the first group and 10,1 U/ml to 75,0 U/ml in the second group. Using a cut-off point of 30 U/ml the sensitivity of CA 15-3 was 62,5% and the specificity 93,2% respectively. Mean CA 15-3 values of the negative and positive bone scan groups were significantly different (p=0,0361). The high negative predictive value of CA 15-3 may help to establish which patients will benefit from bone scan procedure. (authors) 42 refs., 2 tabs

  2. Comparison of CA15-3 and CEA in breast cancer

    International Nuclear Information System (INIS)

    Rajkovaca, Z.; Mijatovic, J.; Matavulj, A.; Kovacevic, P.; Ponorac, N.

    2002-01-01

    Aim: Tumor markers are potentially powerful means for obtaining information about cancers whilst causing minimal morbidity, inconvenience and cost. CA 15-3 and CEA are considered useful tumor markers in monitoring breast cancer patients. The aim of this study was to evaluate which of these two markers are in better correlate with the disease in patients surgically treated for breast cancer. Material and Methods: We retrospectively reviewed values of CA15-3 and CEA in 342 patients (median age 52.18 years, range 27-78 years) with surgically treated and pathologically proven breast cancer. CA15-3 and CEA was measured by radioimmunoassay. CA15-3 levels above 30 U/ml and CEA levels above 5 ng/ml were considered as positive values. Results: Out of 342 patients, 86 had elevated CA15-3 levels (sensitivity: 25.1%) and 68 of 342 patients had positive CEA levels (sensitivity 19.9%). Two hundred thirty seven (237) of the patients suffering from breast cancer (69.3%) did not have metastatic disease. In this group CA15-3 sensitivity was 94.5%, while CEA sensitivity was 87.3%. One hundred and five (105) patients (30.7%) had metastatic disease. In this group, CA15-3 sensitivity was 69.5% and CEA sensitivity was 36.2% (P < 0.05). With regard to the correlation of the two tumor markers with clinical course patients had significantly higher levels of CA15-3 than of CEA in metastatic breast cancer. Conclusion: This result suggests CA15-3 to be the more sensitive and more specific of the two tumor markers for metastatic breast cancer detection and monitoring

  3. Significance of the tumor markers CA 125 and CA 15-3 in postoperative diagnosis of ovarian and breast cancer

    International Nuclear Information System (INIS)

    Johannsen, B.; Bartel, U.; Elling, D.

    1989-01-01

    In 271 patients with ovarian carcinoma, benign ovarian tumors, breast cancer, and two control groups, serum levels of CA 125, CA 15-3, CEA and, partly, CA 19-9 were determined immunoradiometrically. According to the results of the determination of CA 125 in the follow-up of ovarian carcinoma, CA 125 represents a useful marker for early detection of recurrences, especially in cases of diffuse carcinoma dissemination. In incomplete tumor debulking, postoperative CA 125 serum levels did not prove to be helpful except that a positive level renders invasive diagnostic investigation no longer necessary. Postoperative follow-up in breast cancer early reveals distant metastases, with very high levels in patients with bone metastases. By simultaneous measurement of CA 15-3 and CEA the sensitivity could be increased from 86% (CA 15-3 only) to 93%. (author)

  4. Evaluation of preoperative predictive values of serum CA15-3 and ...

    African Journals Online (AJOL)

    Evaluation of preoperative predictive values of serum CA15-3 and CEA within Sudanese ... Sudan Journal of Medical Sciences ... Design and setting: This case control study was conducted in Khartoum Teaching Hospital, Khartoum, Sudan.

  5. CA 15-3: uses and limitation as a biomarker for breast cancer.

    LENUS (Irish Health Repository)

    Duffy, Michael J

    2012-02-01

    CA 15-3 which detects soluble forms of MUC-1 protein is the most widely used serum marker in patients with breast cancer. Its main use is for monitoring therapy in patients with metastatic disease. In monitoring therapy in this setting, CA 15-3 should not be used alone but measured in conjunction with diagnostic imaging, clinical history and physical examination. CA 15-3 is particularly valuable for treatment monitoring in patients that have disease that cannot be evaluated using existing radiological procedures. CA 15-3 may also be used in the postoperative surveillance of asymptomatic women who have undergone surgery for invasive breast cancer. In this setting, serial determination can provide median lead-times of 5-6 months in the early detection of recurrent\\/metastatic breast cancer. It is unclear however, whether administering systemic therapy based on this lead-time improves patient outcome. Consequently, expert panels disagree on the utility of regularly measuring CA 15-3 in the postoperative surveillance of asymptomatic women following a diagnosis of breast cancer. The main limitation of CA 15-3 as a marker for breast cancer is that serum levels are rarely increased in patients with early or localized disease.

  6. Usefulness of serum CA-15.3 in the management of benign breast lesion.

    Science.gov (United States)

    Mondal, Hari Pada; Roy, Himanshu; Mondal, Palash; Saha, Mita; Basu, Nandita

    2012-04-01

    Benign breast lesion is an important risk factor for breast cancer and elevated CA-15.3 in serum is a well established marker of breast cancer. Core-needle biopsy is now the method of choice to sample non-palpable mammographic abnormality and as well as clinically palpable lesion. To asses relationship of serum CA-15.3 with different histologic entities of benign breast lesion and usefulness of this marker in predicting breast cancer in this high risk group, a study was conducted among 140 patients who had a diagnosis of benign breast lesion and malignancy following fine needle aspiration cytology (FNAC) at department of surgery, Medical College, Kolkata between 2007 and 2009. We prospectively estimated serum CA-15.3 level in all patients. Different histologic entities of benign breast lesion, who showed serum CA-15.3 level >30U/ml underwent tru-cut biopsy to detect malignancy. Of 140 patients studied, 50 were stamped as malignancy and 90 as benign after FNAC of which 20 patients had fibroadenoma, 25 had fibro-adenoma with fibrocystic disease, 20 had fibrocystic disease with epitheliosis and 25 had fibrocystic disease with atypia. All breast cancer patients and 10 each from fibro-adenoma with fibrocystic disease, fibrocystic disease with epitheliosis and fibrocystic disease with atypia had serum CA -15.3 level>30U/ml. Thirty patients with benign breast lesion who had raised CA-15.3 underwent core-needle biopsy. Fifteen patients were detected to have intraductal carcinoma, mostly with fibrocystic disease with atypia. Clinical applicability of serum CA-15.3 to detect breast cancer should be strongly considered in management of patients with benign breast lesion and tru-cut biopsy than FNAC be done before benign breast lesion being stamped as benign. Biopsy results that are not concordant with the targeted lesion require surgical biopsy.

  7. Prognostic value of monitoring tumour markers CA 15-3 and CEA during fulvestrant treatment

    Directory of Open Access Journals (Sweden)

    Locker Gottfried J

    2006-03-01

    Full Text Available Abstract Background At many centres tumour markers are used to detect disease recurrence and to monitor response to therapy in patients with advanced disease, although the real value of serial observation of marker levels remains disputed. In this study, we evaluated the prognostic value of tumour markers for predicting response (partial response [PR], stable disease [SD] ≥ 6 months, de novo disease progression (PD and secondary PD in patients receiving fulvestrant ('Faslodex' 250 mg/month for the treatment of metastatic breast cancer (MBC. Methods Changes in cancer antigen 15–3 (CA 15-3 and carcinoembryonic antigen (CEA were prospectively monitored (monthly and were also evaluated for the 3 months preceding secondary PD. Data from 67 patients with previously treated MBC participating in a Compassionate Use Programme were analysed. Results In patients with a PR (n = 7 [10.4%], a non-significant increase in CA 15-3 occurred during the first 6 months of treatment; CEA was significantly reduced (P = 0.0165. In patients with SD ≥ 6 months (n = 28 [41.8%], both CA 15-3 (P P = 0.0399 levels increased significantly after 6 months treatment. In those experiencing de novo PD (n = 32 [47.8%], CA 15-3 increased significantly (P P = 0.0002 during the same time period. Both CA 15-3 (P P Conclusion CA 15-3 increases in patients progressing on fulvestrant but may also increase in those experiencing clinical benefit; this should not be taken as a sign of PD without verification. Overall, both CA 15-3 and CEA appear to be poor prognostic markers for determining progression in patients receiving fulvestrant.

  8. CA15.3 Serum Concentrations in Older Women with Infiltrating Ductal Carcinomas of the Breast

    Directory of Open Access Journals (Sweden)

    Álvaro Ruibal

    2014-10-01

    Full Text Available Breast cancer is currently becoming a disease of the elderly. We have studied the relation between CA 15.3 serum concentrations and clinical-pathological parameters in 69 women with IDC aged over 70 years (76.3 ± 4.2; range: 71–88; median 76. A group of 205 women with the same tumor but aged <70 years (62.8 ± 4.0; range: 55–70; median 63 was also considered for comparison. Tumor size, axillary lymph node involvement, distant metastasis and histological grade were taken account. Serum CA 15.3 was determined by luminescence assay. CA 15.3 serum concentrations ranged between 6 and 85 U/mL (median 22.9 U/mL, and were higher only in patients with greater (qualitative and quantitative; p: 0.041 tumor size. Our results show that in women with IDCs, and aged over 70 years, serum CA 15.3 serum concentrations are associated exclusively with a greater tumor size, being these findings different to those described in women with the same subtype of tumor considered as a whole or with lower age.

  9. Comparison of breast cancer mucin (BCM) and CA 15-3 in human breast cancer

    NARCIS (Netherlands)

    Garcia, M.B.; Blankenstein, M.A.; Wall, E. van der; Nortier, J.W.R.; Schornagel, J.H.; Thijssen, J.H.H.

    1990-01-01

    The Breast Cancer Mucin (BCM) enzyme immunoassay utilizes two monoclonal antibodies (Mab), M85/34 and F36/22, for the identification of a mucin-like glycoprotein in serum of breast cancer patients. We have compared BCM with CA 15-3, another member of the human mammary epithelial antigen

  10. Assessment of CA 15.3, CEA and TPA concentrations during monitoring of breast cancer

    DEFF Research Database (Denmark)

    Sölétormos, G; Petersen, P H; Dombernowsky, P

    2000-01-01

    The variability of the tumor markers cancer antigen (CA) 15.3, carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA) during steady state concentrations and the rate of increase during progression is described. One hundred and ninety-two patients were monitored during first...... with above cutoff level values. Clinical and marker progression was registered for 75 (CA 15.3), 62 (CEA), and 57 (TPA) patients. The coefficients of total variation of steady state concentrations (comprising the intra- and interassay analytical imprecision and the within subject biological variation) were...... for TPA (0.0346). Our data indicate that criteria for assessment of sequential tumor marker concentrations should consider the marker in question, the steady state variability, the cutoff value, and the rate of increase during disease progression....

  11. CA 15-3 and lipid profile in preoperative breast cancer patients

    International Nuclear Information System (INIS)

    Jamall, S.; Ishaq, M.; Khadim, M.; Alam, J.M.

    2010-01-01

    The transmembrane glycoprotein CA 15-3 is the most widely used serum tumor marker in breast cancer. At present the main uses of CA 15-3 are in pre-clinically detecting recurrent breast cancer and monitoring the treatment of patients with advanced breast cancer. The aim of this study was to define the role of preoperative concentrations of serum CA 15-3a sp rognostic factor and to determine its sensitivity. Serum and plasma samples from breast cancer patients and normal individuals under fasting condition were used to estimate CAlS-3 and lipid profile. The lipid profile was done in order to assess the impact of plasma lipid on the progression of breast cancer. The serum concentration of the tumor marker CAlS-3 in preoperative breast cancer patients was found to be significantly higher (p<0.001) as compared to the normal individuals. The plasma cholesterol (TC), triglyceride (TRG) and total lipid (TL) levels in breast cancer patients were found to be significantly higher (p< O.OI) for TC, TRG and TL as compared to the normal individuals. Moreover, plasma LDL-C levels in breast cancer patients were found to be significantly higher (p< O.OI) compared to the normal individuals. (author)

  12. Sensitivity of CA 15-3, CEA and serum HER2 in the early detection of recurrence of breast cancer

    DEFF Research Database (Denmark)

    Eriksen, Ann Christina; Sørensen, Patricia Diana; Jacobsen, Erik Hugger

    2013-01-01

    The aim of this project was to investigate the sensitivity of CA 15-3, CEA and HER2 in the early diagnosis of metastatic breast cancer.......The aim of this project was to investigate the sensitivity of CA 15-3, CEA and HER2 in the early diagnosis of metastatic breast cancer....

  13. The role of tumor marker CA 15-3 in detection of breast cancer relapse after curative mastectomy

    International Nuclear Information System (INIS)

    Hyun, In Young; Kim, In Ho; Lee, Moon Hee; Kim, Chul Soo

    2004-01-01

    The purpose of this study was to determine the utility of tumor marker CA 15-3 in the following: the diagnosis of breast cancer relapse after curative mastectomy, and the differentiation of the value of tumor marker by site of metastases. Two hundred two patients (median age 48 years) with breast cancer included in the follow-up after curative mastectomy. The tumor marker CA 15-3 was determined by IRMA (CIS BIO INTERNATIONAl, France). Test values > 30 U/ml were considered elevated (positive). Among 202 patients, recurrent diseases were found in 16 patients. CA 15-3 was elevated in 5 of 16 patients with recurrences. There was no false-positive patients who had elevated CA 15-3. Sensitivity and specificity of CA 15-3 for detection of breast cancer recurrence were 31%, and 100%. CA 15-3 was elevated in all of the 4 patients with liver metastases. CA 15-3 was elevated in none of the patients who relapsed with metastasis to bone-only or contralateral breast-only. The tumor marker CA 15-3 in the detection of breast cancer relapse after curative mastectomy is specific, but not sensitive. However, it is useful to rule out liver metastases of breast cancer, which indicates bad prognosis

  14. The possible role of tumor antigen CA 15-3, CEA and ferritin in malignant and benign disease

    OpenAIRE

    Nafija Serdarević; Samira Mehanović

    2012-01-01

    Introduction: Serum CA15-3 has been one of the most reliable tumor markers used in monitoring of breast cancer patients. To increase its sensitivity, the combined measurement of other tumor markers (CEA and ferritin) with CA15-3 was investigated. The aim of this study was determination of CA 15-3, CEA and ferritin in female patients with breast cancer, lung cancer and mastitisMethods: 300 patients with carcinoma, hospitalized at Department of Gynecologic Oncology and Department for Oncology a...

  15. Human gallbladder carcinoma: Role of neurotrophins, MIB-1, CD34 and CA15-3.

    Science.gov (United States)

    Artico, M; Bronzetti, E; Alicino, V; Ionta, B; Bosco, S; Grande, C; Bruno, M; Tranquilli Leali, F M; Ionta, G; Fumagalli, L

    2010-03-11

    Gallbladder carcinoma is the most common biliary tract tumor and the fifth most common gastrointestinal tract cancer .The prognosis of gallbladder carcinoma is poor and less than 5% of the patients are still alive five years postoperatively. Gallbladder specimens were obtained during surgical operations performed in eleven patients for resection of a gallbladder carcinoma, and during five autopsies (control cases selected among patients who died from for other causes, excluding those suffering from biliary or hepatic diseases). Immunohistochemical characterization and distribution of neurotrophins, with their respective receptors, were analyzed. The actual role played by these neurotrophic factors in the general regulation, vascular permeability, algic responsiveness, release of locally active substances and potential tumorigenesis in the gallbladder and biliary ducts compartment remains controversial. Our study revealed an increased immunohistochemical expression of NGF and TrKA in the epithelium and in the epithelial glands of the gallbladder carcinoma together with an evident immunoreactivity for BDNF in the same neoplastic areas. An evident immunoreactivity for NGF, TrKA and BDNF was observed in control specimens of gallbladder obtained during autopsies, whereas a weak or quite absent immunoreactivity was observed in the same specimens for NT4, TrKC and p75. On the contrary an appreciable immunoreactivity for p75 was observed in the specimens harvested from patients with gallbladder carcinoma. We also investigated the expression of some known tumor markers such as MIB-1 (anti Ki-67), CD34 and CA15-3, to identify a possible correlation between the expression of these molecular factors and the prognosis of gallbladder carcinoma. They resulted highly expressed in the stroma (CD34 and CA 15-3) and in the epithelium/epithelial glands (MIB-1) of the neoplastic areas and appeared to be almost absent in the control cases, suggesting that these markers, taken together

  16. Human gallbladder carcinoma: Role of neurotrophins, MIB-1, CD34 and CA15-3

    Directory of Open Access Journals (Sweden)

    M. Artico

    2010-03-01

    Full Text Available Gallbladder carcinoma is the most common biliary tract tumor and the fifth most common gastrointestinal tract cancer .The prognosis of gallbladder carcinoma is poor and less than 5% of the patients are still alive five years postoperatively.1 Gallbladder specimens were obtained during surgical operations performed in eleven patients for resection of a gallbladder carcinoma, and during five autopsies (control cases selected among patients who died from for other causes, excluding those suffering from biliary or hepatic diseases. Immunohistochemical characterization and distribution of neurotrophins, with their respective receptors, were analyzed. The actual role played by these neurotrophic factors in the general regulation, vascular permeability, algic responsiveness, release of locally active substances and potential tumorigenesis in the gallbladder and biliary ducts compartment remains controversial. Our study revealed an increased immunohistochemical expression of NGF and TrKA in the epithelium and in the epithelial glands of the gallbladder carcinoma together with an evident immunoreactivity for BDNF in the same neoplastic areas. An evident immunoreactivity for NGF, TrKA and BDNF was observed in control specimens of gallbladder obtained during autopsies, whereas a weak or quite absent immunoreactivity was observed in the same specimens for NT4, TrKC and p75. On the contrary an appreciable immunoreactivity for p75 was observed in the specimens harvested from patients with gallbladder carcinoma. We also investigated the expression of some known tumor markers such as MIB-1 (anti Ki-67, CD34 and CA15-3, to identify a possible correlation between the expression of these molecular factors and the prognosis of gallbladder carcinoma. They resulted highly expressed in the stroma (CD34 and CA 15-3 and in the epithelium/epithelial glands (MIB-1 of the neoplastic areas and appeared to be almost absent in the control cases, suggesting that these markers

  17. The diagnostic value of serum tumor markers CEA, CA19-9, CA125, CA15-3, and TPS in metastatic breast cancer.

    Science.gov (United States)

    Wang, Weigang; Xu, Xiaoqin; Tian, Baoguo; Wang, Yan; Du, Lili; Sun, Ting; Shi, Yanchun; Zhao, Xianwen; Jing, Jiexian

    2017-07-01

    This study aims to understand the diagnostic value of serum tumor markers carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9), cancer antigen 125 (CA125), cancer antigen 15-3 (CA15-3), and tissue polypeptide-specific antigen (TPS) in metastatic breast cancer (MBC). A total of 164 metastatic breast cancer patients in Shanxi Cancer Hospital were recruited between February 2016 and July 2016. 200 breast cancer patients without metastasis in the same period were randomly selected as the control group. The general characteristics, immunohistochemical, and pathological results were investigated between the two groups, and tumor markers were determined. There were statistical differences in the concentration and the positive rates of CEA, CA19-9, CA125, CA15-3, and TPS between the MBC and control group (Ptumor marker at 56.7% and 97.0%, respectively. In addition, two tumor markers were used for the diagnosis of MBC and the CEA and TPS combination had the highest diagnostic sensitivity with 78.7%, while the CA15-3 and CA125 combination had the highest specificity of 91.5%. Analysis of tumor markers of 164 MBC found that there were statistical differences in the positive rates of CEA and CA15-3 between bone metastases and other metastases (χ 2 =6.00, P=0.014; χ 2 =7.32, P=0.007, respectively). The sensitivity and specificity values of the CEA and CA15-3 combination in the diagnosis of bone metastases were 77.1% and 45.8%, respectively. The positive rate of TPS in the lung metastases group was lower than in other metastases (χ 2 =8.06, P=0.005).There were significant differences in the positive rates of CA15-3 and TPS between liver metastases and other metastases (χ 2 =15.42, Ptumor markers have varying diagnostic value. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. The possible role of tumor antigen CA 15-3, CEA and ferritin in malignant and benign disease

    Directory of Open Access Journals (Sweden)

    Nafija Serdarević

    2012-09-01

    Full Text Available Introduction: Serum CA15-3 has been one of the most reliable tumor markers used in monitoring of breast cancer patients. To increase its sensitivity, the combined measurement of other tumor markers (CEA and ferritin with CA15-3 was investigated. The aim of this study was determination of CA 15-3, CEA and ferritin in female patients with breast cancer, lung cancer and mastitisMethods: 300 patients with carcinoma, hospitalized at Department of Gynecologic Oncology and Department for Oncology at the University Clinics Center of Sarajevo and 200 healthy subjects were compared.Results: In patients with breast cancer the mean value of tumor markers were CEA 155.61 ng/mL, CA 15-3 106.38 U/mL and ferritin 197.03 ng/mL. In patients with lung cancer CEA was 58.97 ng/ml, CA 15-3 40.62 U/mL and ferritin 544.16 ng/mL. Patients with mastitis had CEA 5.17 ng/mL, CA 15-3 112.67 U/mL and ferritin 174.92 ng/mL. The control group had values of tumor markers CEA 1.62 ng/mL, CA 15-3 11.72 U/mL and ferritin 85.35 ng/mL. We found good correlation between CA 15-3 and CEA correlation coeffi cient was r = 0.750. There was a low correlation between CA 15-3 and ferritin with correlation coeffi cient r = 0.274.Conclusions: The CA 15-3 and CEA are useful markers in patients with confi rmed diagnosis of breast and lung cancers. The ferritin concentration has not increased in patients with breast cancer but it increased inlung patients. The future study has to make investigations of tumor markers and ferritin in different stage of breast cancer.

  19. Combined Evaluation of AFP, CA15-3, CA125, CA19-9, and CEA Tumor Markers in Patients with Hepatitis B and C.

    Science.gov (United States)

    Assmar, Mehdi; Yeganeh, Sara; Mansourghanaei, Fariborz; Amirmozafari, Nour

    2016-12-01

    This study aimed to determine the role of tumor markers AFP, CA15-3, CA125, CA19-9 and CEA in patients with hepatitis B and C. This descriptive cross-sectional study was performed from Oct 2012 to Oct 2014. Serum samples of 129 patients with hepatitis B and C referred to Guilan Liver and Digestive Disease Research Center in Rasht, Iran were collected and checked for the existence of the listed tumor markers by ELISA. No increase in serum levels of tumor marker CA19-9, CEA and CA15-3 were seen in patients with hepatitis ( P >0.05). In patients with hepatitis B, increase in CA125 were observed ( P =0.03). In hepatitis C patients, there was an increase in AFP levels ( P =0.03). The levels of AFP and CA125 markers were high in hepatitis C and hepatitis B, respectively. However, the increased levels were not seen is malignancy. Due to the small sample size, further study is necessary to find the reasons of the increase.

  20. Comparative study on 3 imaging techniques and serum marker CA15-3 in diagnosis of breast cancer

    International Nuclear Information System (INIS)

    Zahng Shiqin; Hu Xin; Li Hong'e; Yan Huaixin

    2009-01-01

    Objective: To investigate the clinical value of detecting breast cancer with 3 imaging techniques(Ultrasound, Full-field digital mammography, Magnetic resonance imagery) and serum marker CA15-3. Methods: Sixty-six pathologically proven patients with breast cancer were examined with Ultrasound before operation, 58 cases were examined with Full-field digital mammography, 30 cases were examined by Magnetic resonance imagery, the serum marker CA15-3 was detected with CLIA in 58 cases. Results: The accurate rates of US, MO and MRI for diagnosis of breast cancer were respectively significantly higher than that of CA15-3(P 0.05) (the accuracy of US was 86.4%, the accuracy of MO was 93.2%, the accuracy of MRI was 96.7%). Conclusion: Ultrasonography,due to its reasonably good accuracy with very low cost, might be selected as the first choice of non-invasive diagnosis of breast cancer. (authors)

  1. Multiple bony metastases of breast cancer. Role of CA 15.3 and response to hormone therapy

    International Nuclear Information System (INIS)

    Lopez C, Nayara; Ramon G, Natividad; Sanchez M, Jose Ignacio; De Santiago G, Javier

    2012-01-01

    Bone metastases are involved in a 65-75% of advanced metastatic breast cancer cases. Tumoral markers (CEA, CA 15.3) are useful in the follow-up and evaluation of response to treatment. Hormonal therapy is the optimal treatment option in low grade metastatic breast cancer due to low toxicity and general long term good response. We present a breast cancer case treated with surgery, chemotherapy and radiotherapy. The patient was asymptomatic during the follow-up and multiple bone metastases were diagnosed as a result of an increased CA 15.3 marker found. Hormone therapy was the recommended initial treatment with good response and tolerance. Bone lesions remained stabilized for 7 years but after treatment suspension new bone lesions appeared. CA 15.3 marker had increased again. Reintroduction of hormonal therapy achieved again the stabilization of the lesions

  2. Effect of rabdosia rubescens combined with new assistant chemotherapy on serum CA199, CEA, CA15-3 and T lymphocyte subsets in patients with breast cancer

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    Lei Xi

    2018-07-01

    Full Text Available Objective: To study the effects of Rabdosia rubescens combined with neoadjuvant chemotherapy on serum CA199, CEA, CA15-3 levels and T lymphocyte subsets in patients with breast cancer. Methods: A total of 70 patients with breast cancer in our hospital were enrolled as the subjects of this study. The subjects were divided into control group (n=35 and treatment group (n=35 randomly. Patients in the control group were treated with new assistant chemotherapy, while those who were in the treatment group were treated with rabdosia rubescens combined with new assistant chemotherapy. The two groups of patients were treated for 3 periods. The serum CA199, CEA, CA15-3 levels and peripheral blood CD4+, CD8+, CD4+/CD8+ cells of the two groups before and after treatment were compared. Results: There were no significantly differences among the serum CA199, CEA, CA15-3 levels and peripheral blood CD4+, CD8+, CD4+/CD8+ cells of the two groups before treatment. The serum CA199, CEA and CA15-3 levels of the two groups after treatment were significantly lower than those before treatment, besides, the serum CA199, CEA and CA15-3 levels of the treatment group were significantly lower than those of the control group. The peripheral blood CD4+, CD4+/ CD8+ cells of the control group after treatment were significantly lower than before treatment, and the peripheral blood CD4+, CD4+/CD8+ cells of the treatment group after treatment were significantly higher than those of the control group. Conclusion: Rabdosia rubescens combined with new assistant chemotherapycan can significantly reduce the serum CA199, CEA and CA15-3 levels, and improve peripheral blood CD4+, CD8+, CD4+/CD8+ levels of patients with breast cancer. It is worthy of clinical application.

  3. Menstrual Cycle Dependent Variability for Serum Tumor Markers CEA, AFP, CA 19-9, CA 125 and CA 15-3 in Healthy Women

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    Ayşe Binnur Erbağci

    1999-01-01

    Full Text Available Information on menstrual cycle dependent variation of tumor markers in healthy women is a subject of diagnostic efficiency and has an impact in elucidating the normal function of these markers. In this study midfollicular and midluteal concentrations of serum CEA, AFP, CA 19-9, CA 125, CA 15-3 and their relations with LH, FSH, prolactin, estradiol and progesterone were evaluated during ovulatory cycles in a group of 23 healthy female individuals. Samples were collected on the 7th and 21st day of the same menstrual cycle. Tumor marker and hormone concentrations were determined with chemiluminescence or electrochemiluminescence EIA methods. A significant phase-dependent difference was observed for CA 15-3, midluteal concentrations (mean ± SEM; 26.33 ± 1.56 U/ml higher than the midfollicular (mean ± SEM; 19.27 ± 1.49 U/ml concentrations (p < 0.001. But an obvious difference for other tumor markers investigated did not exist. Significant correlations of follicular and luteal CA 125 levels with body mass index of the subjects were observed (r:0.52, p < 0.05 and r:0.57, p < 0.005, respectively.

  4. Monitoring the response of breast cancer to radiotherapy and adjuvant therapy using breast cancer antigen CA 15-3

    International Nuclear Information System (INIS)

    Bafarag, Saeed Mohamed Ibrahim

    2001-05-01

    In this study 35 breast cancer patients were followed during their treatment in Radiation and Isotope Center of Khartoum (RICK) using breast cancer antigen CA 15-3 as an indicator of tumor marker. They were classified into three categories of CA 15-3 concentration level as stated by Colomer and Genolla (1989) as follows: normal level less than 40 UI/ml, moderate level more than 40 UI/ml and less than 60 UI/ml, and high level, more than 60 UI/ml to 3000 UI/ml. A 5 ml of venous blood samples' were collected using sterile syringes from patients with different stage of breast cancer. The sample size were thirty-five cases, one of the cases is rejected because the patient discontinued the treatment. The blood samples were collected as follows: before starting the treatment course, at the mid time of treatment course, after completion the treatment course, and after one month of completion of the treatment course. The patients classified into two groups according to their treatment protocol. The first group received only external radiation therapy treatment and those were 18 patients out of 35, while the second group received combined therapy and those were 16 patients out of 35. For those whom received external radiation radiation therapy only, the results showed that the mean value of CA 15-3 concentration level decreased at the mid of the treatment as follows: 26±3 UI/ml, 24±3 UI/ml, 22±3 UI/ml respectively, while the mean value of CA 15-3 concentration level before starting the treatment was found to be 46±14 UI/ml. The number of the patients in the normal concentration level of CA 15-3 increased by 11% at the mid of external radiotherapy treatment and by 13% at the mid combined therapy, while the moderate level decreased by 6% for both external radiotherapy and combined therapy, while the number of patients within the high level decreased by 5% for external radiotherapy and 7% for combined therapy. After completion and after one month of completion of external

  5. Elevated Levels of Serum Tumor Markers CEA and CA15-3 Are Prognostic Parameters for Different Molecular Subtypes of Breast Cancer

    OpenAIRE

    Shao, Yingbo; Sun, Xianfu; He, Yaning; Liu, Chaojun; Liu, Hui

    2015-01-01

    Background & Aims The utility of measuring carcinoembryonic antigen(CEA) and cancer antigen 15-3 (CA15-3) levels in patients with breast cancer remains controversial. The present study aims to investigate the prognostic value of preoperative serum CEA and CA15-3 levels in breast cancer patients. Methods Serum preoperative CEA and CA 15-3 concentration levels were measured in a total of 432 breast cancer patients. The association of tumor markers levels with clinicopathological parameters and ...

  6. CA 15-3 predicting breast cancer relapse: beware of vitamin B12 deficiency.

    Science.gov (United States)

    Rassy, Elie El; Ghor, Maya Al; Kattan, Joseph

    2018-05-10

    A sustained increase of cancer antigen 15-3 serum levels was found in a 54-year-old woman treated 2 years ago for early stage breast cancer, without any evidence of cancer recurrence. The patient thereafter developed severe megaloblastic anemia secondary to vitamin B12 deficiency. Supplementation with B12 to reverse the anemia led to the normalization of the cancer antigen 15-3 serum levels. As such, with the limited understanding of molecular biology, the integrative approach of clinical history, physical examination, and diagnostic imaging remain pivotal in the management of cancer patients.

  7. Elevated Levels of Serum Tumor Markers CEA and CA15-3 Are Prognostic Parameters for Different Molecular Subtypes of Breast Cancer.

    Science.gov (United States)

    Shao, Yingbo; Sun, Xianfu; He, Yaning; Liu, Chaojun; Liu, Hui

    2015-01-01

    The utility of measuring carcinoembryonic antigen(CEA) and cancer antigen 15-3 (CA15-3) levels in patients with breast cancer remains controversial. The present study aims to investigate the prognostic value of preoperative serum CEA and CA15-3 levels in breast cancer patients. Serum preoperative CEA and CA 15-3 concentration levels were measured in a total of 432 breast cancer patients. The association of tumor markers levels with clinicopathological parameters and outcomes were analyzed. Elevated serum levels of CEA and CA15-3 were identified in 47 (10.9%) and 60(13.9%) patients, respectively. Larger tumor size, advanced axillary lymph nodal and TNM stage exhibited higher proportion of elevated CEA and CA15-3 levels. The elevation of CEA levels was significantly greater in patients with HER2 positive tumors, and the elevation of CA15-3 levels was significantly greater in ER negative breast patients. Univariate and multivariate Cox's regression analysis revealed that elevated preoperative CEA and CA 15-3 levels were independent prognostic factors for DFS and OS. When considering the combination of both markers levels, patients with both elevated markers presented the worst survival. Independent prognostic significance of elevated preoperative serum CEA and CA15-3 levels were reconfirmed in Luminal B breast cancer. Preoperative serum levels of CEA and CA15-3 are independent prognostic parameters for breast cancer.

  8. Elevated Levels of Serum Tumor Markers CEA and CA15-3 Are Prognostic Parameters for Different Molecular Subtypes of Breast Cancer.

    Directory of Open Access Journals (Sweden)

    Yingbo Shao

    Full Text Available The utility of measuring carcinoembryonic antigen(CEA and cancer antigen 15-3 (CA15-3 levels in patients with breast cancer remains controversial. The present study aims to investigate the prognostic value of preoperative serum CEA and CA15-3 levels in breast cancer patients.Serum preoperative CEA and CA 15-3 concentration levels were measured in a total of 432 breast cancer patients. The association of tumor markers levels with clinicopathological parameters and outcomes were analyzed.Elevated serum levels of CEA and CA15-3 were identified in 47 (10.9% and 60(13.9% patients, respectively. Larger tumor size, advanced axillary lymph nodal and TNM stage exhibited higher proportion of elevated CEA and CA15-3 levels. The elevation of CEA levels was significantly greater in patients with HER2 positive tumors, and the elevation of CA15-3 levels was significantly greater in ER negative breast patients. Univariate and multivariate Cox's regression analysis revealed that elevated preoperative CEA and CA 15-3 levels were independent prognostic factors for DFS and OS. When considering the combination of both markers levels, patients with both elevated markers presented the worst survival. Independent prognostic significance of elevated preoperative serum CEA and CA15-3 levels were reconfirmed in Luminal B breast cancer.Preoperative serum levels of CEA and CA15-3 are independent prognostic parameters for breast cancer.

  9. Value of Combined Detection of Serum CEA, CA72-4, CA19-9, CA15-3 and CA12-5 in the Diagnosis of Gastric Cancer.

    Science.gov (United States)

    Chen, Changguo; Chen, Qiuyuan; Zhao, Qiangyuan; Liu, Min; Guo, Jianwei

    2017-05-01

    To examine whether the combined detection of serum tumor markers (CEA, CA72-4, CA19-9, CA15-3 and CA12-5) improves the sensitivity and accuracy in the diagnosis of gastric cancer (GC). An automatic chemiluminescence immune analyzer with matched kits was used to determine the levels of serum CEA, CA72-4, CA19-9, CA15-3, and CA12-5 in 87 patients with gastric cancer (GC group), 60 patients with gastric benign diseases (GBD group) who were hospitalized during the same period, and 40 healthy subjects undergoing a physical examination. The values of these 5 tumor markers in the diagnosis of gastric cancer were analyzed. The levels of serum CEA, CA72-4, CA19-9, and CA12-5 were higher in the GC group than in the GBD group and healthy subjects, and these differences were significant ( P 0.05). The combined detection of CEA, CA72-4, CA19-9, and CA12-5 had a higher diagnostic value for gastric cancer than did single detection, and the positive detection rate of the combined detection of the four tumor markers was 60.9%. The diagnostic power when using the combined detection of CA72-4, CEA, CA19-9, and CA12-5 was the best. The combined detection of serum CA72-4, CEA, CA19-9 and CA12-5 increases the sensitivity and accuracy in the diagnosis of GC and can thus be considered an important tool for early diagnosis. © 2017 by the Association of Clinical Scientists, Inc.

  10. Cation-exchange antibody labeling for simultaneous electrochemical detection of tumor markers CA15-3 and CA19-9

    International Nuclear Information System (INIS)

    Wang, Guangjie; Qing, Yi; Shan, Jinlu; Jin, Feng; Wang, Dong; Yuan, Ruo

    2013-01-01

    We report on a new kind of non-covalent multi-label electrochemical immunoassay that was applied to simultaneously quantify the tumor markers CA15-3 and CA19-9. The method employs a nanohybrid composed of an ionomer and conductive titanium dioxide nanoparticles that act as a matrix support for the antibodies. The two antibodies (anti-CA153 and anti-CA199) were labeled (a) with a cobaltous dipyridine complex, and (b) with methylene blue. Labeling is based on cation-exchange interaction rather than on covalent conjugation. The redox potentials of the two labels are separated by an interval of 0.3 V. The resulting sandwich-type immunosensor was read out by differential pulse voltammetry. The potential sites and currents of the two redox probes reflect the concentration of the two analytes. The two analytes were determined with a detection limit of 1.6 U mL −1 for CA19-9, and of 0.3 U mL −1 for CA15-3 (author)

  11. Evaluation of normal values of Ca-15-3 and PSA for the people of Northern State of Sudan

    International Nuclear Information System (INIS)

    Bafaraj, S.M.I.

    2007-06-01

    In this study blood samples were collected from 665 female from Northern State of Sudan, 606 of those females are married and only 59 females are singles. These samples were used to estimate the normal CA 15-3 which was found to be similar to the international one and that is ranged from zero to 35 mlu/ml. When the same techniques were used using samples collected from patients who have been clinically diagnosed as breast cancer, CA 15-3 levels were found to be higher in most of these samples and the other finding is that the risk of getting breast cancer is starting from age 25 years. On the other hand , 650 males were participated in this study to estimate normal value of PSA, of them 553 were married. And again the levels estimated for this marker was found to be the same as that used globally which is ranged from zero to four ng/ml. When blood samples from prostate patients were assayed for PSA, the results showed high levels of this marker in almost all the samples as expected but the important finding is that prostate cancer is age depend. At the end of the project, many recommendations highlighted to be considered in the near future.(Author)

  12. The Potential Ability of Plaster to Cause Breast Cancer as Indicated by CA15-3 and CEA Antigens in Women Working in Gypsum Factory

    Directory of Open Access Journals (Sweden)

    Ali Abdul Hussein S. AL-Janabi

    2017-07-01

    Full Text Available Plaster is an important form of gypsum that mainly used in building construction. Breast cancer was investigated among women exposure to the dust of such material. The levels of CA15-3 and carcinoembryonic antigens (CEA as indicators for breast cancer were measured in the serum of 120 women working in a plaster factory. All of involved women showed a normal level of CEA, while 12.5% of them had moderately elevated levels of CA15-3. In conclusion; plaster dust has no significant effect to cause breast cancer in working women. Moderately high levels of CA15-3 in some of exposed women may relate to liver diseases. Key words: Breast Cancer, Plaster, CA15-3, CEA

  13. Application of Measurements of Serum CA15-3 and B-AKP in Diagnosis of Bone Metastasis in Patients with Post-operative Mammary Cancer

    International Nuclear Information System (INIS)

    Liu Yan; Zhang Xia; Yuan Shiqiang

    2010-01-01

    To evaluate the diagnosis value of serum CA15-3 and B-AKP measurements in diagnosis of bone metastasis images in patients with post-operative mammary cancer, retrospective study on the bone scan images and serum CA15-3 and bone alkaline phosphatase (B-AKP) levels were performed in 92 patients with confirmed post-operative mammary gland cancer. The results showed that the serum levels of CA15-3 and B-AKP were increased step by step significantly along with the advancement of bone metastatic grading from M0 to M3 (P<0.01). The serum levels of CA15-3 and B-AKP were positively correlated with the number of bone metastasis. The positive rate of bone metastasis was 63.2% with serum CA15-3 more than 25U/mL; and the negative predictive value of bone metastasis was 94.5% with serum CA15-3 less than 25U/mL. The positive rate of bone metastasis was 59.6% with serum B-AKP levels more than 20U/L; and the negative predictive value of bone metastasis was 73.5% with serum B-AKP levels less than 20U/L. The negative predictive value of bone metastasis was 100% with serum CA15-3 less than 25U/mL and serum B-AKP levels less than 20U/L. The combined measurement of the serum CA15-3 and B-AKP levels would play an important role in diagnosis of bone scan images in patients with post-operative mammary cancer. (authors)

  14. Diagnostic efficacy of CA 15-3 and CEA in the early detection of metastatic breast cancer-A retrospective analysis of kinetics on 743 breast cancer patients.

    Science.gov (United States)

    Stieber, Petra; Nagel, Dorothea; Blankenburg, Irene; Heinemann, Volker; Untch, Michael; Bauerfeind, Ingo; Di Gioia, Dorit

    2015-08-25

    We investigated the diagnostic capacity of CEA and CA 15-3 kinetics for the early detection of metastatic disease in comparison to fixed cut off values. In a retrospective analysis, a total of 743 patients with early breast cancer and available baseline values of CEA and CA 15-3 were included. A reproducible increase of 100% of single or combined markers was considered as a strong indicator of metastatic disease. 187 patients developed metastatic disease and 556 remained disease-free. On the basis of tumor marker kinetics, we reached a specificity of >98% for both biomarkers and a sensitivity of 40.6% for CEA alone, 55.6% for CA 15-3 alone and 66.3% for the combination of both markers. Using fixed cut-off values (CEA: 4ng/mL, CA 15-3: 30U/mL) we ended up with a specificity of 86.3% and a sensitivity of 70.6% for the combination of CEA and CA 15-3. Using higher cut-off values (CEA: 6ng/mL, CA 15-3: 60U/mL) we reached a specificity of 96.9% and a sensitivity of 49.7% for the combination. We conclude that the interpretation of these markers in follow-up using individual baseline values and kinetics leads to a significant superior profile of specificity and sensitivity. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Study on IL-2 and CA 15-3 level as combined biomarkers in monitoring chemotherapeutic response among invasive breast cancer patients

    Science.gov (United States)

    Hameed, Ahmed Muthanna Abdul; Hamid, Auni Fatin Abdul; Shahfiza Noor, Nurul; Appalanaido, Gokula Kumar; Bariyah Sahul Hamid, Shahrul

    2017-05-01

    In Malaysia, breast cancer is the most frequent type of disease among women. This study was designed to determine the clinical usefulness of carbohydrate antigen (CA 15-3) and interleukin 2 (IL-2) levels as combined biomarkers in monitoring breast cancer patient’s response to chemotherapy. Ethical approval was obtained to recruit patients with histologically confirmed invasive ductal carcinoma (IDC) attending Oncology Clinic at Advanced Medical and Dental Institute. Whole blood was collected from 10 IDC breast cancer patients’ pre and post primary chemotherapy. Plasma was separated from the whole blood to determine the CA 15-3 level and IL-2 level using enzyme-linked immunosorbent assay (ELISA) pre and post-treatment. In addition, the histological findings, tumour stage and other patients’ data were obtained from the medical record. Findings showed that IL-2 had borderline significant changes between pre- and post-chemotherapy (p = 0.074) whereas for CA 15-3, there was insignificant differences of CA 15-3 level between pre and post-chemotherapy (p > 0.05). It was noted that only CA 15-3 level had significant correlation with tumour size. This study demonstrates that IL-2 level requires further investigation in a larger sample size to correlate its potential use as combined biomarker with CA 15-3 in monitoring response to chemotherapy.

  16. The value of combined examination of serum CA15-3, CEA level and whole body bone scan in the diagnosis of bone metastasis in breast cancer

    International Nuclear Information System (INIS)

    Lu Baoshi; Gao Yufang

    2011-01-01

    Objective: To explore the value of combined examination of serum tumormarkers carbohydrate antigen 15-3 (CA15-3), carcinoembryonic antigen (CEA) and whole body bone scan in the diagnosis of bone metastasis in breast cancer. Methods: Whole body bone scan and serum CA15-3 and CEA levels with a electrochemical luminescence assay were performed in 97 patients with breast cancer (46 cases with bone metastasis and 51 cases without bone metastasis) and 45 patients with benign breast diseases. As for the negative cases who had significant pains in bones, CT or MRI was performed to make sure. Results: The serum level of CA15-3 and CEA were significantly higher in patients with bone metastasis than those in patients without bone metastasis and the benign lesions. The positive predicting values were 76.09% and 80.43%. Most patients with bone metastasis had positive results in bone scan (95.65%), only 2 cases had negative results (4.35%), which is positive by CT or MRI Seven. Seven patients without bone metastasis and Three patients with the benign lesions had positive results in bone scan, that may be caused by previous operation or injury. The combined determination of CA15-3, CEA and whole body bone scan had a better performance in sensitivity, specificity and accuracy than each single way. Conclusion: The combined determination of CA 15-3, CEA and whole body bone scan were valuable in the diagnosis of bone metastasis in breast cancer. (authors)

  17. Elevated levels of serum tumor markers CA 15-3 and CEA are prognostic factors for diagnosis of metastatic breast cancers.

    Science.gov (United States)

    Lee, Jun Sang; Park, Seho; Park, Ji Min; Cho, Jung Hoon; Kim, Seung Il; Park, Byeong-Woo

    2013-10-01

    To investigate the prognostic value of tumor markers, cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA) levels at diagnosis of systemic recurrence. After primary treatments of locoregional breast cancers, serum CA 15-3 and/or CEA concentrations were regularly measured, and systemic recurrences were identified in 351 patients between January 1999 and December 2009. The association between tumor marker levels at systemic recurrence and survival were investigated by univariate and multivariate analyses. Elevated CA 15-3 and CEA levels were identified in 194 of 349 (55.6 %) and 111 of 308 (36.0 %) patients, respectively, at diagnosis of systemic recurrence. Elevated levels of CA 15-3 and CEA were correlated with visceral or multiple recurrences and elevated preoperative levels. Elevation of CA 15-3 was more prominent in younger patients and in primary node-positive tumors, while CEA was elevated in older patients at diagnosis and in estrogen receptor (ER)-positive tumors. Elevated tumor markers as well as ER negativity, short disease-free interval, and advanced stage at initial diagnosis showed independent prognostic significance on multivariate analysis. Among 306 patients for whom levels of both tumor markers at recurrence were available, 106 patients without elevation of either marker showed significantly better overall survival than those with elevated levels of either one or both markers, and the significance persisted in multivariate analysis. Elevated serum CA 15-3 and CEA levels at recurrence suggest increased tumor burden and may be prognostic for survival for metastatic breast cancer patients.

  18. Sensing CA 15-3 in point-of-care by electropolymerizing O-phenylenediamine (oPDA on Au-screen printed electrodes.

    Directory of Open Access Journals (Sweden)

    Rui S Gomes

    Full Text Available This work presents an alternative device for cancer screening in liquid biopsies. It combines a biomimetic film (i with electrochemical detection (ii. The biomimetic film (i was obtained by electro-polymerizing amine-substituted benzene rings around a CA 15-3 target. This protein target was previously adsorbed on a gold (Au support and incubated in charged monomers (4-Styrenesulfonate sodium and 3-Hydroxytyraminium chloride. The protein was further eliminated by enzymatic activity, leaving behind vacant sites for subsequent rebinding. Electrochemical detection (ii was achieved on an Au working electrode, designed on commercial screen-printed electrodes. Raman spectroscopy, atomic force microscopy and ellipsometric readings were used to follow the chemical modification of the Au surface. The ability of the material to rebind CA15-3 was monitored by electrochemical techniques. The device displayed linear responses to CA15-3 ranging from 0.25 to 10.00 U/mL, with detection limits of 0.05 U/mL. Accurate results were obtained by applying the sensor to the analysis of CA15-3 in PBS buffer and in serum samples. This biosensing device displayed successful features for the detection of CA 15-3 and constitutes a promising tool for breast cancer screening procedures in point-of-care applications. Moreover, its scale-up seems feasible as it contains a plastic antibody assembled in situ, in less than 1 minute, and the analysis of serum takes less than 30 minutes.

  19. Clinical performance of LOCI™-based tumor marker assays for tumor markers CA 15-3, CA 125, CEA, CA 19-9 and AFP in gynecological cancers.

    Science.gov (United States)

    Dolscheid-Pommerich, Ramona C; Keyver-Paik, Mignon; Hecking, Thomas; Kuhn, Walther; Hartmann, Gunther; Stoffel-Wagner, Birgit; Holdenrieder, Stefan

    2017-10-01

    Evidence is sparse regarding the clinical performance of luminescent oxygen channeling immunoassays-based tumor marker assays in gynecological cancer. Analyzing serum samples of 336 patients with Dimension™Vista1500, we investigated the diagnostic power of carbohydrate antigen 15-3, carbohydrate antigen 125, carcinoembryonic antigen, carbohydrate antigen 19-9, and alpha-fetoprotein in patients suffering from different types of gynecological cancer and precancerous gynecological diseases and compared findings to appropriate control groups. The cohort comprised 177 female patients with gynecological cancers (73 breast, 22 cervical, 16 endometrial, 17 vulva, and 49 ovarian cancers), 26 patients with precancerous gynecological diseases (11 vulva, 4 cervical, and 10 breast), 109 patients with benign gynecological diseases, and 24 healthy controls. Discriminative power was assessed by areas under the curve in receiver operating characteristic curves, and sensitivities were determined at a fixed specificity of 95%. Levels of biomarkers in healthy controls were in the expected ranges and a discriminative power between gynecological cancers and healthy controls was observed for several tumor markers. Established tumor type-associated markers were elevated in specific gynecological cancers and benign controls as well as within precancerous gynecological diseases and healthy control group. In ovarian cancer, carbohydrate antigen 125 and carbohydrate antigen 15-3 were significantly elevated compared to the respective benign diseases. Carbohydrate antigen 125 was the most conclusive marker (area under the curve = 0.86% and 77.6% sensitivity at 95% specificity). In breast cancer, carcinoembryonic antigen and carbohydrate antigen 15-3 were significantly higher than in the respective benign diseases. Carcinoembryonic antigen achieved the most conclusive area under the curve (0.65) with 31.5% sensitivity at 95% specificity. None of the investigated markers was found to be of

  20. Comparison of bone scintigraphy with serum tumor markers of CA 15-3 and carcinoembryonic antigen in patients with breast carcinoma

    International Nuclear Information System (INIS)

    Gedik, G. K.; Kiratli, P.O.; Aras, T.; Tascioglu, B.

    2006-01-01

    To compare the bone scintigraphy findings with a carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA 15-3) levels in breast carcinoma patients. We also investigated the relationship between anatomical bone type and its effect on tumor marker levels. The study was consisted of retrospective evaluation of 120 bone scans of patients with breast carcinoma admitted to the Nuclear Medicine Department, Medical Faculty, Hacettepe University, Ankara, Turkey between January 2003 and December 2004. The mean age of the patients was 54.7 years. We grouped the results of the bone scans into 3 as normal, equivocal and metastatic. Carcinoembryonic antigen and CA 15-3 levels were recorded from the files of the patients. Upper cut levels of 4.8 U/ml for CEA and 38 U/ml for CA 15-3 was accepted. Metastatic bone areas were distributed according to their anatomical location as long, short, flat, irregular and sesamoid and effect of bone type on tumor marker was investigated. In 16 of the patients, bone scintigraphy revealed metastases. Sixty-one patients had normal scans and in 47 patients metastases could not be ruled out. In patients with metastases, CA 15-3 was elevated in 8 and CEA was higher than the upper limit in 6. For CEA and CA 15-3, the anatomical type of bone has no any effect on serum tumor marker concentration between patients with normal and elevated levels of tumor markers in metastatic patients. Tumor markers are not solely enough in predicting bone metastases. Bone scintigraphy and tumor markers should be both used in management of patients with breast carcinoma. The anatomical type of bone has no any effect on elevation of serum tumor marker concentration. (author)

  1. Concordance of Hypermethylated DNA and the Tumor Markers CA 15-3, CEA, and TPA in Serum during Monitoring of Patients with Advanced Breast Cancer

    DEFF Research Database (Denmark)

    Kristiansen, Søren; Jørgensen, Lars Mønster; Høgh Hansen, Morten

    2015-01-01

    The serological protein tumor markers CA 15-3, CEA, and TPA are frequently used to monitor tumor burden among metastatic breast cancer patients. Breast cancer is associated with global DNA hypomethylation and hypermethylation of some promoter regions. No monitoring study has yet investigated the ...

  2. Mucins CA 125, CA 19.9, CA 15.3 and TAG-72.3 as tumor markers in patients with lung cancer: comparison with CYFRA 21-1, CEA, SCC and NSE.

    Science.gov (United States)

    Molina, Rafael; Auge, Jose Maria; Escudero, Jose Miguel; Marrades, Ramon; Viñolas, Nuria; Carcereny, Emilio; Ramirez, Jose; Filella, Xavier

    2008-01-01

    Tumor marker serum levels were prospectively studied in 289 patients with suspected, but unconfirmed, lung cancer and in 513 patients with lung cancer [417 non-small cell lung cancer (NSCLC) patients and 96 small cell lung cancer (SCLC) patients]. In patients with benign disease, abnormal serum levels were found for the following tumor markers: CEA (in 6.6% of patients); CA 19.9 (6.2%); CA 125 (28.7%); NSE (0.7%); CYFRA (8.7%); TAG-72.3 (4.2%); SCC (3.5%), and CA 15.3 (3.5%). Excluding patients with renal failure or liver diseases, tumor marker specificity improved with abnormal levels in 0.5% for NSE, 0.9% for SCC, 2.8% for CEA, CA 15.3 and TAG-72.3, 3.8% for CA 19.9, 4.2% for CYFRA and 21.4% for CA 125. Excluding CA 125, one of the markers was abnormal in 15% of patients without malignancy. Tumor marker sensitivity was related to cancer histology and tumor extension. NSE had the highest sensitivity in SCLC and CYFRA and CEA in NSCLC. Significantly higher concentrations of CEA, SCC, CA 125, CA 15.3 and TAG-72.3 were found in NSCLC than in SCLC. Likewise, significantly higher CEA (p tumors. Using a combination of 3 tumor markers (CEA, CYFRA 21-1 in all histologies, SCC in squamous tumors and CA 15.3 in adenocarcinomas), a high sensitivity may be achieved in all histological types. Tumor markers may be useful in the histological differentiation of NSCLC and SCLC. Using specific criteria for the differentiation of SCLC and NSCLC, the sensitivity was 84.2 and 68.8%, the specificity was 93.8 and 99.7%, the positive predictive value was 98.3 and 98.5% and the negative predictive value was 57.7 and 93.3%, respectively. Copyright 2008 S. Karger AG, Basel.

  3. Disposable electrochemical detection of breast cancer tumour marker CA 15-3 using poly(Toluidine Blue) as imprinted polymer receptor.

    Science.gov (United States)

    Ribeiro, J A; Pereira, C M; Silva, A F; Sales, M Goreti F

    2018-06-30

    In this work, electrically-conducting poly(Toludine Blue) was employed for the first time as synthetic receptor film, prepared by Molecular Imprinting strategies and using electrochemical methods, for the specific screening of breast cancer biomarker Carbohydrate Antigen 15-3 (CA 15-3). The protein imprinted poly(Toluidine Blue) film was grown in a pre-formed Toluidine Blue (TB) tailed SAM at the AuSPE surface, which greatly enhanced the stability against degradation of the Molecular Imprinted Polymer (MIP) film at the electrode surface. The MIP receptor film recognition ability towards the protein was investigated by fitting data to Freundlich isotherm. The binding affinity (K F ) obtained for the MIP system was significantly higher (~ 12-fold) to that obtained for the NIP system, demonstrating the success of the approach in creating imprinted materials that specifically respond to CA 15-3 protein. The incubation of the MIP modified electrode with increasing concentration of protein (from 0.10 U mL -1 to 1000 U mL -1 ) resulted in a decrease of the ferro/ferricyanide redox current. The device displayed linear response from 0.10 U mL -1 to 100 U mL -1 and LODs below 0.10 U mL -1 were obtained from calibration curves built in neutral buffer and diluted artificial serum, using DPV technique, enabling the detection of the protein biomarker at clinically relevant levels. The developed MIP biosensor was applied to the determination of CA 15-3 in spiked serum samples with satisfactory results. The developed device provides a new strategy for sensitive, rapid, simple and cost-effective screening of CA 15-3 biomarker. Importantly, the overall approach seems suitable for point-of-care (PoC) use in clinical context. Copyright © 2018. Published by Elsevier B.V.

  4. Study on the status of breast and prostate cancers in Gazira State using (CA-15-3 and PSA) technology

    International Nuclear Information System (INIS)

    Abd Elgadir, O.M.

    2007-06-01

    This study was conducted in Algezira State in two environmentally and economically different areas. The people in these areas were divided into two groups in the study: group (A) people who live alongside the Blue Nile bank. Group people who live away how the Blue Nile, I e in midland between the Blue Nile and White Nile which is called (AI-Bajour). The aim of the study was to recognize the normal rate of breast cancer markers(Carbohydrate Antigen 15-3), which is one of the most common cancers, and the prostate cancer (Prostate Cancer Markers), as compared with the global normal rate, in order to early detect and treat these types of cancers. The study was conducted on 336 men and 304 women, who are different in ages, work and social status. The researcher used an experimental, descriptive and analytical method, and the SPSS program for analysis. The study showed that the results of normal rate as compared with previous studies are typical to the breast cancer markers (carbohydrate antigen 15-3, ranging between (0-40) ngm/ml, where as the normal rate of the prostate cancer markers (PSA) ranges between (0-4) ngm/ml, and according to the previous African and American studies. The studies also showed that the results are different according to the group are different according to the group involved. There is an increase in normal rates of group (A) in the PSA markers. From 177 men, 49 had rated of (4-10) ng/ml, 6 had very high rates (10-20)ng/ml and extremely high rates of 2 samples (>20)ng/ml. It was noticed that the abnormal increase rate is directly proportional to the age development. The study showed high results of breast cancer markers (Carbohydrate antigen 15-3), as compared with the global normal rate (0-40)ng/ml, 6 had very high rates (60-100)ng/ml and extremely high rates (>100)ng/ml. Two women of uterus cancer died. Again the abnormal increase in the rates is directly proportional to age development. The study showed that the results of group (B) is

  5. Significance of CEA, CA15-3 and biochemical markers of bone turnover in the diagnosis of bone metastasis from breast cancer

    International Nuclear Information System (INIS)

    Fan Guanglei; Wan Renming; Peng Mingya; Luan Yufen; Zhao Jun; Liu Jianwen; Xu Longbao

    2013-01-01

    Objective: To evaluate the significance of tumor markers CEA and CA15-3, and biochemical markers of bone turnover (total procollagen type Ⅰ amino-terminal propeptide (TP Ⅰ NP), β-isomerized carboxyterminal propeptide (β-CTx), ALP and PTH) in the diagnosis of bone metastasis from breast cancer. Methods: A total of 78 patients (all females) with mean age (56.72 ± 10.76) years, who were diagnosed with breast cancer, were included in this study. The patients were divided into two groups based on radionuclide bone imaging: with bone metastasis (n=32) and without bone metastasis (n=46). The serum concentrations of CEA, CA15-3, TP Ⅰ NP, β-CTx, PTH, ALP were measured. Gleason scores were evaluated. The diagnostic value was evaluated by ROC curve.The two groups were compared using two-sample t test. The correlations between bone metastasis and tumor markers, bone metastasis and biochemical markers of bone turnover were analyzed with Pearson correlation and logistic analysis. Results: The serum levels of CEA, CA15-3, TP Ⅰ NP, β-CTx, PTH and ALP were significantly higher in the group with bone metastasis than those in the group without bone metastasis (t: 4.16-7.56, all P<0.05). For the diagnosis of bone metastasis from breast cancer, the AUC of CEA, CA15-3, TP Ⅰ NP, [β-CTx, PTH and ALP was 0.815, 0.887, 0.869, 0.852, 0.844, 0.731, respectively. Using the cut-off values of 4.18 μg/L for CEA, 0.04 U/L for CA15-3, 49.70 μg/L for TP Ⅰ NP, 0.47 pg/L for β-CTx,54.90 ng/L for PTH and 49.90 U/L for ALP, the sensitivities were 56.3% (18/32), 75.0% (24/32), 78.1% (25/32), 81.3% (26/32), 78.1% (25/32), 68.8% (22/32) and the specificities were 80.4% (37/46), 84.8% (39/46), 76.1% (35/46), 78.3% (36/46), 69.6% (32/46), 58.7% (27/46), respectively. CEA, CA15-3, TP Ⅰ NP, β-CTx, PTH, ALP and Gleason score were positively correlated with the presence of bone metastasis (r: 0.267-0.636, all P<0.05). CEA, CA15-3, TP Ⅰ NP, β-CTx, PTH and Gleason score were independent

  6. Optofluidic ring resonator sensor for sensitive label-free detection of breast cancer antigen CA15-3 in human serum

    Science.gov (United States)

    Zhu, Hongying; Dale, Paul S.; Fan, Xudong

    2009-05-01

    Breast cancer is the most frequently diagnosed malignancy in women worldwide. Because of its great impact on society, a lot of research funding has been used to develop novel detection tools for aiding breast cancer diagnosis and prognosis. In this work, we demonstrated a simple, fast, and sensitive detection of circulating breast cancer biomarker CA15-3 with opto-fluidic ring resonator (OFRR) sensors. The OFRR sensor employs a thin-walled capillary with wall thickness less than 4 μm. The circular cross section of the capillary forms the optical ring resonator, in which the light circulates in the form of whispering gallery modes (WGMs). The capillary wall is thin enough that the evanescent field of the WGM extends into the capillary core and responds to refractive index changes in the capillary core or close to its interior surface. The WGM spectral position will change when the biomolecules bind to the surface, yielding quantitative and kinetic information about the biomolecule interaction. Here, the direct immunoassay method was employed for the detection of CA15-3 antigen without any signal amplification steps. The sensor performance in both PBS buffer and human serum were investigated, respectively. The experimental detection limit was 5 units/mL in PBS buffer and 30 units/mL for CA15-3 spiked in serum, both of which satisfied clinical diagnosis requirements. The potential use of the OFRR as the point-of-care device for breast cancer detection was tested by measuring the CA15-3 level in blood samples collected from stage IV breast cancer patients and the results were compared with standard clinical test.

  7. Association of dyslipidemia, increased insulin resistance, and serum CA 15-3 with increased risk of breast cancer in urban areas of North and Central India

    Directory of Open Access Journals (Sweden)

    Poonam Kachhawa

    2018-01-01

    Full Text Available Objective: This study aims to determine the association of dyslipidemia and increased insulin resistance (IR with increased breast cancer (BC risk. Materials and Methods: The study group comprised 110 premenopausal and 143 postmenopausal, untreated female BC patients in the age range of 29–72 years. Control group consisted of 117 premenopausal and 141 postmenopausal healthy females in the age range of 23–75. Approximately 8-ml blood samples were drawn to measure various biochemical parameters. Serum glucose, total cholesterol, triglyceride (TG, and high-density lipoprotein-cholesterol were measured. Very low-density lipoprotein-cholesterol (VLDL-C and LDL-C were calculated using Friedewald's formula. Serum insulin and serum CA 15-3 were estimated by immune enzymatic assay. IR was assessed using homeostasis model assessment IR index (HOMA-IR. Results: Clinical variables in the case and control groups were compared using the unpaired Student's t-test. The crude and adjusted odds ratios (ORs and 95% confidence intervals (CIs were calculated by binary logistic regression analysis. Pearson's correlation analysis was used to determine the association between CA 15-3 and variables of interest. Total cholesterol, TG, LDL, VLDL, serum glucose, serum insulin, HOMA-IR, and serum CA 15-3 were significantly higher (P < 0.001 in BC patients compared to those in controls. Significant adjusted ORs with 95% CI were found to be fasting glucose, total cholesterol, and TGs. We also found a significant positive correlation between total cholesterol, TG, LDL, serum glucose, serum insulin, HOMA-IR, and serum CA 15-3. Conclusion: This study confirms the association between dyslipidemia, IR, and increased BC risk.

  8. Clinical applicability of determination of serum tumor markers (CEA, CA15-3 and CA125) levels changes for assessment of efficacy of chemotherapy in patients with breast cancer

    International Nuclear Information System (INIS)

    Xu Junying; Liu Chaoying; Li Jiang; Hu Hong; Wang Runjie

    2009-01-01

    Objective: To study the usefulness of monitoring changes of serum levels of tumor markers (CEA, CA15-3 and CA125) for assessment of efficacy of chemotherapy in patients with breast cancer. Methods: Serum CEA, CA15-3 and CA125 levels were measured with CLIA three days before beginning 1st course of appropriate chemotherapy and 3 weeks after completing 2nd course of treatment in 45 patients with advanced breast cancer (TNM stage III, n=20, stage IV n=25). Results: Expressed as CR, PR, SD and PD as defined by the changes of serum tumor markers levels (according to Bac D.J. et al) were compared with clinically observed ones (WHO standard). The serum levels of Cea, CA15-3 decreased markedly in the CR and PR groups of patients but increased markedly in PD patients (P 0.05). The coincidence rate between the results observed clinically and results derived from tumor marker changes was 50.0% for CEA, 55.6% for CA15-3, 31.1% for CA125 and 73% for three markers combined. Conclusion: Combined determination of the changes of serum levels of three tumor marker would help to make a reasonably satisfactory assessment of efficacy of chemotherapy in patients with breast cancer. (authors)

  9. Avaliação dos valores sérico e pleural dos marcadores tumorais CEA, CYFRA21-1 e CA 15-3 em portadores de derrame pleural Evaluation of serum and pleural levels of the tumor markers CEA, CYFRA21-1 and CA 15-3 in patients with pleural effusion

    Directory of Open Access Journals (Sweden)

    Isabella Coimbra Wagner

    2007-04-01

    Full Text Available OBJETIVO: Dosar os marcadores tumorais antígeno carcinoembrionário (CEA, fragmento da citoqueratina 19 (CYFRA21-1 e antígeno glicosídico associado a tumor 15-3 (CA 15-3 em sangue e líquido pleural de portadores de derrames pleurais benignos e malignos, avaliando a sensibilidade de cada um deles nesses fluidos. MÉTODOS: Avaliamos prospectivamente 85 pacientes com derrame pleural. O estudo do líquido pleural obedeceu a critérios determinados pela literatura. A dosagem dos marcadores foi realizada por eletroquimioluminescência. A sensibilidade foi determinada sob a condição de que a especificidade fosse > 90%. RESULTADOS: Foram diagnosticados 36 casos malignos (42,4%, 30 benignos (35,3%; em 19 pacientes (22,3%, o diagnóstico foi inconclusivo. Nos casos malignos, os valores de CEA e CYFRA21-1 foram maiores no líquido pleural do que no sangue, fato não observado para o CA 15-3. Nos casos benignos, os valores do CYFRA21-1 foram maiores no líquido pleural do que no soro, enquanto que para o CEA e o CA 15-3, ocorreu o oposto. Todos os marcadores apresentaram diferença significativa entre os casos malignos e benignos, em líquido pleural e soro. Foi encontrada sensibilidade para CEA, CYFRA21-1 e CA 15-3 no líquido pleural de 69,4%, 69,4% e 66,7%, respectivamente e quando associados, foi 80,6%. No soro, a sensibilidade foi 57,1, 71,4 e 48,6% para CEA, CYFRA21-1 e CA 15-3, respectivamente, e quando associados, foi 77%. CONCLUSÃO: Os resultados sugerem que a utilização desses marcadores pode ser útil na diferenciação entre derrames pleurais malignos e benignos.OBJECTIVE: To determine the levels of the tumor markers carcinoembryonic antigen (CEA, cytokeratin 19 fragment (CYFRA21-1 and carbohydrate antigen 15-3 (CA 15-3 in the blood and pleural fluid of patients with benign or malignant pleural effusion, evaluating the sensitivity of each marker in these fluids. METHODS: We prospectively evaluated 85 patients with pleural effusion. The

  10. Evaluation of tumor markers (HER-2/neu oncoprotein, CEA, and CA 15.3) in patients with locoregional breast cancer: prognostic value.

    Science.gov (United States)

    Molina, Rafael; Augé, Jose M; Escudero, Jose M; Filella, Xavier; Zanon, Gabriel; Pahisa, Jaume; Farrus, Blanca; Muñoz, Montserrat; Velasco, Martin

    2010-06-01

    Tumor markers were studied in the sera of 883 untreated patients with primary breast cancer diagnosed between 1989 and 2007. Abnormal human epidermal growth factor receptor 2 (HER-2)/neu levels (>15 ng/mL) were found in 9.5%, carcinoembryonic antigen (CEA) in 15.9%, and cancer antigen (CA) 15.3 in 19.7% of the patients. One or more tumor markers were abnormal in 305 (34.5%) of the 883 studied patients. Significantly higher serum HER-2/neu levels were found in patients with tissue overexpression of this oncoprotein (p CEA, CA 15.3, and HER-2/neu (only in those patients with tissue overexpression) serum levels were related with tumor stage (tumor size and nodal involvement) and steroid receptors (higher values in estrogen receptor-negative (ER-) tumors). Univariate analysis showed that HER-2/neu serum levels were prognostic factors in disease-free survival (DFS) and overall survival (OS) only in patients with tissue overexpression. Multivariate analysis in 834 patients show that nodal involvement, tumor size, ER, CEA, and adjuvant treatment were independent prognostic factors in DFS and OS. When only patients with HER-2/neu overexpression in tissue were studied, tumor size, nodal involvement, and tumor markers (one or another positive) were independent prognostic factors for both DFS and OS. HER-2/neu serum levels were also an independent prognostic factor, with CEA, ER, and nodes in 106 patients treated with neoadjuvant treatment. In summary, serum HER-2/neu, CEA, and CA 15.3 are useful tools in the prognostic evaluation of patients with primary breast cancer.

  11. Tumor markers in the early detection of tumor recurrence in breast cancer patients: CA 125, CYFRA 21-1, HER2 shed antigen, LDH and CRP in combination with CEA and CA 15-3.

    Science.gov (United States)

    Di Gioia, Dorit; Blankenburg, Irene; Nagel, Dorothea; Heinemann, Volker; Stieber, Petra

    2016-10-01

    Kinetics of CA 15-3 and CEA have a high specificity in the early detection of metastatic breast cancer (MBC). However, this high specificity is associated with a lack of sensitivity. To decrease the number of false negative patients, the additional diagnostic potential of an extended panel of biomarkers was evaluated. This analysis was performed as part of a large follow-up study (1998-2010) evaluating 813 patients with a median follow-up of 63months. After primary therapy, all patients underwent tumor marker monitoring for CEA and CA 15-3 at 6-week intervals. A reproducible previously defined increase (≥100%) based on the individual baseline value of each patient was considered as a strong indicator of MBC. For the present analysis, we retrospectively evaluated 1011 blood samples from 95 patients. Forty-seven of these had metastatic disease for the first time at the time of this evaluation, while the remaining 48 patients showed no evidence of disease. The sera of these patients were additionally assessed for the following parameters: cancer antigen (CA) 125, cytokeratin-19 soluble fragment (CYFRA 21-1), HER2 shed antigen, lactate-dehydrogenase (LDH) and C-reactive protein (CRP). 26 of 47 patients with MBC showed a reproducible tumor marker increase of at least CEA and/or CA 15-3 (55.3%, true-positive). The remaining 21 patients with MBC showed no increase in CEA or CA 15-3 (44.7%, false negative, FN). By combining all markers mentioned above, 41 of 47 patients with MBC showed a reproducible marker increase with a sensitivity of 87.2% and specificity of 100%. This retrospective analysis indicates that a panel of biomarkers can increase the sensitivity of the CA 15-3/CEA combination without loss of specificity. The combined use is therefore helpful for early detection of MBC. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. An innovative immunosensor for ultrasensitive detection of breast cancer specific carbohydrate (CA 15-3) in unprocessed human plasma and MCF-7 breast cancer cell lysates using gold nanospear electrochemically assembled onto thiolated graphene quantum dots.

    Science.gov (United States)

    Hasanzadeh, Mohammad; Tagi, Solmaz; Solhi, Elham; Mokhtarzadeh, Ahad; Shadjou, Nasrin; Eftekhari, Aziz; Mahboob, Soltanali

    2018-04-03

    The accurate quantification of the level of breast cancer specific protein CA 15-3 in serum is crucial for cancer prognosis. This work, a novel and sensitive label-free immunoassay based on gold nanospear (Au NSs) electrochemically assembled onto thiolated graphene quantum dots (CysA/GQDs) for the detection of CA 15-3 antibodies. The CysA/Au NSs/GQDs hybrid interface provides a large surface area for the effective immobilization of CA 15-3 antigens, as well as it ascertains the bioactivity and stability of immobilized CA 15-3 antigens. Field emission scanning electron microscope (FE-SEM), and EDS photoelectron spectroscopies were used to monitor the sensor fabrication. Also, cyclic voltammetry was used to quantify the extent of Au NSs' surface coverage by CA 15-3 antigens. Square wave voltammetry (SWV) was employed to investigate the immunosensor fabrication and to monitor the binding events between CA 15-3 antigens-antibodies. Under optimized experimental conditions, the immunosensor displayed good sensitivity and specificity. The CA 15-3 were detected in a concentration as low as 0.11U/mL with a linear range from 0.16-125U/mL. The high sensitivity of the immunosensor may derive from the high loading of CA 15-3 antibodies on CysA/Au NSs/GQDs hybrid interface which increases the number of binding events. The method was successfully applied assay of the CA 15-3 in unprocessed human plasma samples. Also, proposed immunosensor was applied to the assay of CA 15-3 malignant cell line lysates (human breast adenocarcinoma cell line-MCF-7). Copyright © 2018. Published by Elsevier B.V.

  13. Concordance of Hypermethylated DNA and the Tumor Markers CA 15-3, CEA, and TPA in Serum during Monitoring of Patients with Advanced Breast Cancer.

    Science.gov (United States)

    Kristiansen, Søren; Jørgensen, Lars Mønster; Hansen, Morten Høgh; Nielsen, Dorte; Sölétormos, György

    2015-01-01

    The serological protein tumor markers CA 15-3, CEA, and TPA are frequently used to monitor tumor burden among metastatic breast cancer patients. Breast cancer is associated with global DNA hypomethylation and hypermethylation of some promoter regions. No monitoring study has yet investigated the interrelationship between protein tumor markers, the global DNA hypomethylation, and hypermethylated genes in serum from patients with advanced disease. Twenty-nine patients with histologically proven advanced breast cancer received first-line chemotherapy with epirubicin. Samples were collected prior to each treatment and prospectively analyzed for CA 15-3, CEA, and TPA. The same samples were retrospectively analyzed for the concentration of hypermethylated RASSF1A and for global DNA hypomethylation using LINE-1. Among patients with elevated concentrations of the protein markers, concordance could be observed between serial changes of the hypermethylated RASSF1A gene and the protein markers. Among patients with lower concentrations, RASSF1A could only be detected periodically. There was discordance between changes of the hypomethylated LINE-1 as compared to the protein markers. Circulating hypermethylated RASSF1A and protein markers may have similar kinetics during monitoring of tumor burden. Further investigations are needed to determine whether any of the hypermethylated DNA genes may provide predictive information during monitoring.

  14. Concordance of Hypermethylated DNA and the Tumor Markers CA 15-3, CEA, and TPA in Serum during Monitoring of Patients with Advanced Breast Cancer

    Directory of Open Access Journals (Sweden)

    Søren Kristiansen

    2015-01-01

    Full Text Available The serological protein tumor markers CA 15-3, CEA, and TPA are frequently used to monitor tumor burden among metastatic breast cancer patients. Breast cancer is associated with global DNA hypomethylation and hypermethylation of some promoter regions. No monitoring study has yet investigated the interrelationship between protein tumor markers, the global DNA hypomethylation, and hypermethylated genes in serum from patients with advanced disease. Twenty-nine patients with histologically proven advanced breast cancer received first-line chemotherapy with epirubicin. Samples were collected prior to each treatment and prospectively analyzed for CA 15-3, CEA, and TPA. The same samples were retrospectively analyzed for the concentration of hypermethylated RASSF1A and for global DNA hypomethylation using LINE-1. Among patients with elevated concentrations of the protein markers, concordance could be observed between serial changes of the hypermethylated RASSF1A gene and the protein markers. Among patients with lower concentrations, RASSF1A could only be detected periodically. There was discordance between changes of the hypomethylated LINE-1 as compared to the protein markers. Circulating hypermethylated RASSF1A and protein markers may have similar kinetics during monitoring of tumor burden. Further investigations are needed to determine whether any of the hypermethylated DNA genes may provide predictive information during monitoring.

  15. Assessment of average of normals (AON) procedure for outlier-free datasets including qualitative values below limit of detection (LoD): an application within tumor markers such as CA 15-3, CA 125, and CA 19-9.

    Science.gov (United States)

    Usta, Murat; Aral, Hale; Mete Çilingirtürk, Ahmet; Kural, Alev; Topaç, Ibrahim; Semerci, Tuna; Hicri Köseoğlu, Mehmet

    2016-11-01

    Average of normals (AON) is a quality control procedure that is sensitive only to systematic errors that can occur in an analytical process in which patient test results are used. The aim of this study was to develop an alternative model in order to apply the AON quality control procedure to datasets that include qualitative values below limit of detection (LoD). The reported patient test results for tumor markers, such as CA 15-3, CA 125, and CA 19-9, analyzed by two instruments, were retrieved from the information system over a period of 5 months, using the calibrator and control materials with the same lot numbers. The median as a measure of central tendency and the median absolute deviation (MAD) as a measure of dispersion were used for the complementary model of AON quality control procedure. The u bias values, which were determined for the bias component of the measurement uncertainty, were partially linked to the percentages of the daily median values of the test results that fall within the control limits. The results for these tumor markers, in which lower limits of reference intervals are not medically important for clinical diagnosis and management, showed that the AON quality control procedure, using the MAD around the median, can be applied for datasets including qualitative values below LoD.

  16. 18F-FDG-PET/CT in patients with breast cancer and rising Ca 15-3 with negative conventional imaging: A multicentre study

    International Nuclear Information System (INIS)

    Grassetto, Gaia; Fornasiero, Adriano; Otello, Daniele; Bonciarelli, Giorgio; Rossi, Elena; Nashimben, Ottorino; Minicozzi, Anna Maria; Crepaldi, Giorgio; Pasini, Felice; Facci, Enzo; Mandoliti, Giovanni; Marzola, Maria Cristina; Al-Nahhas, Adil; Rubello, Domenico

    2011-01-01

    Objectives: Breast cancer is the second cause of death in women in Europe and North America. The mortality of this disease can be reduced with effective therapy and regular follow up to detect early recurrence. Tumor markers are sensitive in detecting recurrent or residual disease but imaging is required to customize the therapeutic option. Rising tumor markers and negative conventional imaging (US, X-mammography, CT and MR) poses a management problem. Our aim is to assess the role of 18 F-FDG-PET/CT in the management of post-therapy patients with rising markers but negative conventional imaging. Materials and methods: In the period from January 2008 to September 2009, 89 female patients with breast cancer who developed post-therapy rising markers (serum Ca 15-3 levels = 64.8 ± 16.3 U/mL) but negative clinical examination and conventional imaging were investigated with 18 F-FDG-PET/CT. Results: Tumor deposits were detected in 40/89 patients in chest wall, internal mammary nodes, lungs, liver and skeleton. The mean SUVmax value calculated in these lesions was 6.6 ± 1.7 (range 3.1–12.8). In 23/40 patients solitary small lesion were amenable to radical therapy. In 7 out of these 23 patients a complete disease remission lasting more than 1 year was observed. Conclusions: 18 F-FDG-PET/CT may have a potential role in asymptomatic patients with rising markers and negative conventional imaging. Our findings agree with other studies in promoting regular investigations such as tumor markers and 18 F-FDG-PET/CT rather than awaiting the developments of physical symptoms as suggested by current guidelines since the timely detection of early recurrence may have a major impact on therapy and survival.

  17. Serum levels of CA15-3, AFP, CA19-9 and CEA tumor markers in cancer care and treatment of patients with impaired renal function on hemodialysis.

    Science.gov (United States)

    Estakhri, Rasoul; Ghahramanzade, Ali; Vahedi, Amir; Nourazarian, Alireza

    2013-01-01

    Since renal failure causes decrease in tumor marker excretion, use of these markers in cancer care and treatment in patients with renal insufficiency or hemodialysis is controversial. The aim of this study was to investigate differences of serum levels of tumor markers CA15-3, AFP, CA19-9 and CEA in patients with impaired renal function. A total of 100 patients referred to the Tabriz Immam Reza and Amiralmomenin hospital from June 2010 to November 2011 were selected for study. Subjects were divided to 3 groups of healthy, dialysis and renal failure but non hemodialysis cases, the last category being re-grouped based on creatinine clearance. No significant relationship between different groups in serum levels of CEA (P=0.99) and CA19-9 (P=0.29) tumor markers was found. A significant correlation was observed between serum levels of AFP (PCEA (r=0.05, P=0.625). Creatinine clearance significantly correlated with AFP (Ptumor markers in patients with impaired renal function should be performed with special precautions.

  18. Potential of Anti Breast Cancer Black Ethanol Rice Extract (Oryza sativa L. indica In Decreasing Levels of CA 15-3 Serum in the White Mice Sprague dawley in Induction 7.12-Dimethylbenz (α Antracene (DMBA and Estrogen

    Directory of Open Access Journals (Sweden)

    Zanuar Abidin

    2017-01-01

    Full Text Available Breast cancer is cancer that has the high incidence in Indonesia. Black rice (Oryza sativa L. indica is a plant that has an anticancer potency. This research aim is to prove black rice as a potential anticancer by using experimental animals, 20 Sprague Dawley female rats aged 7-8 weeks induced breast cancer by using the combination of 7,12-dimethylbenz (α anthracene (DMBA and estrogen. Rats were divided into two groups, namely the K-induced breast cancer and a group of P-induced cancer and treated with black rice. Black rice is given in the form of ethanol extract at a dose of 75 mg / kg / day for six weeks. Levels of CA 15-3 serum are used as a parameter. The result showed that the differences in levels of serum CA 15-3 are significant (p <0.05. Serum CA 15-3 level in P group is lower than in K group. This study proved that the ethanol extract of black rice (Oryza sativa L. indica has potential as an anticancer breast as indicated by decreased level of serum CA 15-3

  19. Study on the serum levels of relevant cytokines IL-β, IL-6, IL-8 and tumor markers CEA, CA15-3, PRL in breast cancer patients with bone metastatic lesions shown on SPECT radio-nuclide bone scan

    International Nuclear Information System (INIS)

    Zhu Bao

    2009-01-01

    Objective: To explore the correlationship between SPECT radionuclide bone scan and serum levels of three tumor markers as well as three cytokines in patients with breast cancer. Methods: Serum levels of IL-1β, IL-6, IL-8, CEA, CA15-3(with RIA) and PRL(with CLIA) were determined in 1)20 breast cancer patients with definite bone metastatic lesions shown on radio-nuclide bone scan 2) 20 breast cancer patients without bone metastasis 3) 30 patients with benign breast disorders and 4) 35 controls. Results: The serum tumor markers levels in patients osseous metastasis were significantly higher than those in the other three groups (P 0.05). The serum levels of IL-6, IL-8, IL-1β in patients with osseous metastasis were also significantly higher than those in other groups(P<0.05). Conclusion: Over expression of CEA, CA15-3 and PRL as well as IL-6, IL-8, IL-1β were related with osseous metastasis from breast cancer. Determination of the levels of these six parameters would be helpful for dynamic monitoring of the extent of metastasis. (authors)

  20. Ahorro de energía en la clinkerización empleando CaF2 y CaS04 como mineralizadores. Estudio de la fluorellestadita

    Directory of Open Access Journals (Sweden)

    Vázquez, Tomás

    1981-03-01

    Full Text Available Not availableEl clínker portland está compuesto esencialmente por cuatro fases: alita, belita, fase alumínica y fase ferrítica, que se corresponden de forma aproximada con C3S, C2S, C3A y C4AF (*, respectivamente. Estas dos últimas ("fundentes" tienen como misión principal el facilitar la formación de los hidráulicamente activos, C3S y C2S. Es decir, su aportación a las resistencias mecánicas del cemento hidratado es prácticamente despreciable. Aquellas fases (C3A y C4AF se forman en el horno a partir de los crudos empleados (generalmente caliza y arcilla; su coste energético es elevado ya que además del que precisan para su síntesis les es necesaria una alta proporción de CaO. Este óxido proviene a su vez de la descarbonatación del CaC03, que es el proceso químico que mayor energía consume en la clinkerización. Por ello, una forma que a priori sería válida para ahorrar energía en la fabricación de cemento es la de sustituir total o parcialmente la "fase líquida" (C3A + C4AF tradicional por otra que no precisara tanto CaO, ni que se formara con tan elevado gasto de energía.

  1. 46 CFR 151.15-3 - Construction.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Construction. 151.15-3 Section 151.15-3 Shipping COAST... LIQUID HAZARDOUS MATERIAL CARGOES Tanks § 151.15-3 Construction. This section lists the requirements for construction of the types of cargo tanks defined in § 151.15-1. (a) Gravity type tanks. Gravity type cargo...

  2. The humic matter as natural inhibitor of CaCO{sub 3} in cooling water system; Las sustancias humicas como inhibidores naturales del CaCO{sub 3}, en sistemas de enfriamiento

    Energy Technology Data Exchange (ETDEWEB)

    Celada Murillo, Ana Teresa [Instituto de Investigaciones Electricas, Temixco, Morelos (Mexico)

    2000-07-01

    precipitacion se adicionan al agua de circulacion H{sub 2}SO{sub 4} e inhibidores de precipitacion que contienen polifosfatos (entre los mas utilizados). Estos quimicos traen consigo un impacto ambiental al estar asociados con problemas de eutroficacion de cuerpos de agua. Con el fin de contribuir a la disminucion del uso de aditivos contaminantes, esta investigacion propone la utilizacion de sustancias humicas (SH) como inhibidores naturales de la precipitacion del CaCO{sub 3}. Las SH son moleculas organicas de estructura quimica compleja, presentes en el agua y suelos por la degradacion de plantas y animales muertos, participan en reacciones de complejacion, intercambio ionico y adsorcion con iones metalicos. La inhibicion del CaCO{sub 3} por SH, se observo en soluciones sinteticas y de agua natural (pozo, rio y agua residual tratada), las cuales tenian concentraciones de calcio y alcalinidad tipicas del agua de repuesto y circulacion de sistemas de enfriamiento de centrales termoelectricas. En estas soluciones se indujo la precipitacion del CaCO{sub 3} por la adicion de NaOH 0.1 N en forma continua (metodo del pH critico), en ausencia y presencia de SH. En cada experimento, se registro el tiempo y volumen de hidroxido de sodio agregado para que la precipitacion de CaCO{sub 3} se presentara. La inhibicion de la precipitacion del CaCO{sub 3} por SH, fue evidente por el aumento en el tiempo de inicio de la precipitacion de esta sal. En las soluciones sinteticas este tiempo se incremento entre 30 y 40% y en las de agua natural (pozo) las SH inhibieron la precipitacion del CaCO{sub 3} durante 120 minutos.

  3. 15 CFR 15.3 - Acceptance of service of process.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Acceptance of service of process. 15.3... Process § 15.3 Acceptance of service of process. (a) Except as otherwise provided in this subpart, any... employee by law is to be served personally with process. Service of process in this case is inadequate when...

  4. 44 CFR 15.3 - Access to Mt. Weather.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Access to Mt. Weather. 15.3... HOMELAND SECURITY GENERAL CONDUCT AT THE MT. WEATHER EMERGENCY ASSISTANCE CENTER AND AT THE NATIONAL EMERGENCY TRAINING CENTER § 15.3 Access to Mt. Weather. Mt. Weather contains classified material and areas...

  5. Clinicopathological and Prognostic Significance of Cancer Antigen 15-3 and Carcinoembryonic Antigen in Breast Cancer: A Meta-Analysis including 12,993 Patients

    Directory of Open Access Journals (Sweden)

    Xuan Li

    2018-01-01

    Full Text Available Purpose. The prognostic role of serum cancer antigen 15-3 (CA15-3 and carcinoembryonic antigen (CEA in breast cancer remains controversial. In this study, we conducted a meta-analysis to investigate the prognostic value of these two markers in breast cancer patients. Methods. After electronic databases were searched, 36 studies (31 including information regarding CA15-3 and 23 including information regarding CEA with 12,993 subjects were included. Based on the data directly or indirectly from the available studies, the hazard ratios (HRs and odds ratios (ORs and their 95% confidence intervals (CIs were pooled according to higher or lower marker levels. Results. Elevated CA15-3 or CEA was statistically significant with poorer DFS and OS in breast cancer (multivariate analysis of OS: HR = 2.03, 95% CI 1.76–2.33 for CA15-3; HR = 1.79, 95% CI 1.46–2.20 for CEA; multivariate analysis of DFS: HR = 1.56, 95% CI 1.06–1.55 for CA15-3; HR = 1.77, 95% CI 1.53–2.04 for CEA. Subgroup analysis showed that CA15-3 or CEA had significant predictive values in primary or metastasis types and different cut-offs and included sample sizes and even the study publication year. Furthermore, elevated CA15-3 was associated with advanced histological grade and younger age, while elevated CEA was related to the non-triple-negative tumor type and older age. These two elevated markers were all associated with a higher tumor burden. Conclusions. This meta-analysis showed that elevated serum CA15-3 or CEA was associated with poor DFS and OS in patients with breast cancer, and they should be tested anytime if possible.

  6. Desempeño económico y protesta ciudadana como detonantes de las caídas presidenciales: el caso ecuatoriano

    OpenAIRE

    Basabe-Serrano, Santiago; Polga-Hecimovich, John

    2017-01-01

    Resumen En este artículo argumentamos que las crisis económicas (X1 ) a las que siguen movilizaciones sociales en las calles (X2 ) explican las salidas anticipadas de presidentes (Y). Luego de identificar los puntos de acuerdo y tensión hallados en los trabajos hasta ahora realizados, proponemos que el estudio de las caídas presidenciales puede hallar un espacio fructífero a partir del análisis de causalidad coyuntural múltiple. Mediante dos casos de inestabilidad presidencial ocurridos en Ec...

  7. Assessing Efficacy of Chemotherapy in Breast Cancer Patients Using Serum CA 15-3

    Czech Academy of Sciences Publication Activity Database

    Nekulová, M.; Šimíčková, M.; Pecen, Ladislav; Valík, D.

    2002-01-01

    Roč. 5, - (2002), s. 82-83 ISSN 1211-8869. [Central European Conference on Human Tumor Markers /4./. 13.02.2003-16.02.2003, Karlovy Vary] Institutional research plan: CEZ:AV0Z1030915 Keywords : modelling of curve decrease * tumor marker * therapy evaluation Subject RIV: BB - Applied Statistics, Operational Research

  8. Evaluación de la marcha y el equilibrio como factor de riesgo en las caídas del anciano

    Directory of Open Access Journals (Sweden)

    Mayté Vera Sánchez

    2003-10-01

    Full Text Available Se realizó un estudio descriptivo en el que participaron 104 ancianos de un consultorio médico perteneciente al Policlínico Docente"Mario Escalona Reguera", a los cuales se les realizó una encuesta donde se evalúan varios parámetros relacionados con la marcha y el equilibrio, para determinar el riesgo de caídas según las variaciones encotradas. Se utilizó el método estadístico del Chi cuadrado para asociación de variables y el método porcentual. Encontramos que mientras más edad tienen los ancianos, más riesgo de caídas presentan y esto se relaciona con las alteraciones de la marcha y el equilibrio. Además, el riesgo de sufrir caídas fue más frecuente en el sexo femenino, y los factores de riesgo más frecuentes fueron la necesidad de usar los brazos para levantarse y sentarse, la necesidad del bastón para estar de pie, la marcha con talones separados y no levantar el pie completamente del suelo.A descriptive study of 104 older people from a physician´s office of "Mario Escalona Reguera" teaching polyclinics was performed. These aged persons were administered a survey to evaluate several parameters related to gait and balance, with the purpose of determining fall risks according to the variations found. Chi square statistical method for association of variables and the percentage method were used. We found that risk of falling increases with the age as a result of altered gait and balance. Besides, the risk of falling down was more common in females and the most frequent risk factors were the need of using arms to stand up and sit down and a stick to be on one´s feet, gait characterized by separated heels and not raising completely the feet when walking.

  9. Utilização de zeólitas modificadas CaX e MgX como adsorventes de compostos orgânicos

    Directory of Open Access Journals (Sweden)

    Denise Maria Malachini Miotto

    2002-04-01

    Full Text Available Neste trabalho, foi avaliada a capacidade de adsorção de zeólitas modificadas, CaX e MgX, em contato com uma solução do subproduto do processo de extração de esteviosídeo, um adoçante extraído das folhas de Stevia rebaudiana. Os efeitos do processo de adsorção na estrutura zeolítica foram avaliados por meio de diversas técnicas de caracterização. As análises térmicas mostraram que os compostos adsorvidos sofrem pequenas mudanças estruturais sob aquecimento. A partir da espectroscopia ao infravermelho, foi verificado que o processo de adsorção não modifica a estrutura da zeólita. As medidas de área superficial e volume de poros indicaram que a adsorção ocorre preferencialmente na superfície externa e nos mesoporos. Finalmente, os resultados de acidez indicaram que a adsorção dos compostos orgânicos coloridos ocorre principalmente nos cátions de compensação.

  10. Bagacillo de caña (Saccharum officinarum predigerido por vapor a presión como alimento básico para novillos de carne

    Directory of Open Access Journals (Sweden)

    Ortiz H. Oscar

    1987-03-01

    Full Text Available Al someter el bagacillo a altas presiones (18.3, 19.0, 19.7 y 20.4 kg/cm2 durante 4, 6, 8 y 10 minutos se incrementó significativamente la digestibilidad "in vitro" y la degradabilidad "in situ "de la materia seca. La aceptabilidad del bagacillo predigerido al vapor-BPOJ (O, 40, 60 y 85.42% fue baja y se presentó disminución en el consumo y pérdidas de peso en novillos cebú que consumieron niveles por encima del 60%. No se observaron diferencias significativas (P < 0.05 en la ganancia de peso promedio de novillos alimentados con BPDV y altos niveles de urea, usando una cantidad restringida de pasto rey (TI, bagazo crudo entero (T2 y melaza de caña (T3; la exclusión de fibra larga (T3 no afectó el desempeño animal. Se detectaron niveles de furfural por debajo del 1 % en el BPIN (base fresca; los análisis espectroscópicos (UV, RI, RMN registraron la presencia de grupos carboxilos e hidroxilos, indicando la probable existencia de fenoles.De-rinded sugar cane bagasse (the pith was subjected to high steam pressures (18.3, 19.0, 19.7 and 20.4 kg/cm2 during 4, 5, 8and 10 minutes. In vitro digestibilities and JD. situ degradabilities were significantly improved by the treatments. The steam pre-digested bagasse pith-SPBP (0,20, 40, 60 y 85.42% acceptability were lowand the results showed very high weight losses of steers teed 60 and 80% SPBP of their diet. No statistical difference (P < 0.05 was observed for average daily gains of steer fed on high levels of SPBP supplemented with high levels of urea, using three treatment: restricted amount of king grass (T1 whole raw bagasse (T2 and cane molasses(T3; the exclusion of the long fiber (T3 did not effect animal performance. Furfural levels below 1% SPBP (fresch basis were detected; spectrometric analysis (UV, RI and FMN registered the presence of carboxil and hidroxil groups indicating the probable existence of phenols.

  11. Ferrocenyl-doped silica nanoparticles as an immobilized affinity support for electrochemical immunoassay of cancer antigen 15-3

    International Nuclear Information System (INIS)

    Hong Chenglin; Yuan Ruo; Chai Yaqin; Zhuo Ying

    2009-01-01

    The aim of this study is to elaborate a simple and sensitive electrochemical immunoassay using ferrocenecarboxylic (Fc-COOH)-doped silica nanoparticles (SNPs) as an immobilized affinity support for cancer antigen 15-3 (CA 15-3) detection. The Fc-COOH-doped SNPs with redox-active were prepared by using a water-in-oil microemulsion method. The use of colloidal silica could prevent the leakage of Fc-COOH and were easily modified with trialkoxysilane reagents for covalent conjugation of CA 15-3 antibodies (anti-CA 15-3). The Fc-COOH-doped SNPs were characterized by X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). The fabrication process of the electrochemical immunosensor was demonstrated by using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) techniques. Under optimal conditions, the developed immunosensor showed good linearity at the studied concentration range of 2.0-240 U mL -1 with a coefficient 0.9986 and a detection limit of 0.64 U mL -1 at S/N = 3

  12. Ferrocenyl-doped silica nanoparticles as an immobilized affinity support for electrochemical immunoassay of cancer antigen 15-3.

    Science.gov (United States)

    Hong, Chenglin; Yuan, Ruo; Chai, Yaqin; Zhuo, Ying

    2009-02-09

    The aim of this study is to elaborate a simple and sensitive electrochemical immunoassay using ferrocenecarboxylic (Fc-COOH)-doped silica nanoparticles (SNPs) as an immobilized affinity support for cancer antigen 15-3 (CA 15-3) detection. The Fc-COOH-doped SNPs with redox-active were prepared by using a water-in-oil microemulsion method. The use of colloidal silica could prevent the leakage of Fc-COOH and were easily modified with trialkoxysilane reagents for covalent conjugation of CA 15-3 antibodies (anti-CA 15-3). The Fc-COOH-doped SNPs were characterized by X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). The fabrication process of the electrochemical immunosensor was demonstrated by using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) techniques. Under optimal conditions, the developed immunosensor showed good linearity at the studied concentration range of 2.0-240 UmL(-1) with a coefficient 0.9986 and a detection limit of 0.64 UmL(-1) at S/N=3.

  13. Obtención de fibras policristalinas de b-Ca3(PO42 para su empleo como material de relleno en procesos de reparación ósea

    Directory of Open Access Journals (Sweden)

    Guitián-Rivera, F.

    2007-04-01

    Full Text Available b-TCP is a calcium phosphate ceramic widely employed by orthopaedic restorative surgery as a filler material in bone healing processes, due to its great osteoconductive capacity and great resorption rates. This material is available in several forms such as powders, dense and porous blocks, etc, depending on the pathology and the osseous defect to be treated. As an alternative to the b-TCP forms already available in the market, this work describes how to produce polycrystalline fibres by extruding plastic mixtures prepared with b-TCP powders, methyl cellulose (MC and water. The rheology of the mixtures was studied versus time and frequency. The obtained fibres have different sizes and characteristics upon to the composition and rheology of the mixtures. The obtained diameters are between 150 μm and 350 μm. Finally, it has been prepared biphasic composites b-TCP/Hidroxylapatite (HA with controlled microstructure, by employing the obtained fibres.El b-Ca3(PO42 (b-TCP es un fosfato cálcico ampliamente empleado como material de relleno por la cirugía ortopédico restauradora en procesos de curación ósea, debido a su capacidad osteoconductora y alta tasa de biorreabsorción. Se emplea con distintas formas, tales como granulados, piezas compactas, piezas porosas, etc, dependiendo de la patología y el tipo de defecto óseo a tratar. Como alternativa a las formas ya existentes en el mercado, en el presente trabajo se obtuvieron fibras policristalinas de b-TCP por extrusión de masas plásticas preparadas a partir de polvo de b-TCP y metilcelulosa (MC en agua. Se estudió la reología de las pastas y su comportamiento frente al esfuerzo y a la temperatura. Las fibras presentan distintos grosores, y características, que se obtienen variando el diámetro de las boquillas, la composición y la reología de las pastas. Los diámetros obtenidos van desde 350 μm a 150 μm. Finalmente se obtuvieron composites bifásicos b-TCP-Hidroxiapatito con

  14. Evaluación y análisis de la eficacia del trabajo de la flexibilidad de la cadena miofascial recta posterior y del equilibrio sobre el alcance funcional como predictor de caídas en personas mayores que realizan revitalización geriátrica

    OpenAIRE

    Méndez Sánchez, Roberto

    2014-01-01

    [ES]Las caídas en personas mayores suponen un verdadero problema de salud pública, tanto por las incapacidades que provocan como por el alto índice de mortalidad que conllevan, fundamentalmente a partir de los 80 años. Si esto lo incluimos en el contexto demográfico actual, con un envejecimiento progresivo de la población, hace que cobre mayor importancia la actuación sobre las caídas en personas mayores. Entre los diferentes cambios morfológicos propios del envejecimiento, en este trabajo...

  15. Precipitação de CaCO3 em algas marinhas calcárias e balanço de CO2 atmosférico: os depósitos calcários marinhos podem atuar como reservas planetárias de carbono?

    OpenAIRE

    Carlos Eduardo Amancio

    2007-01-01

    As atividades humanas nos últimos dois séculos vêm provocando um aumento na concentração de dióxido de carbono (CO2) atmosférico. Um dos efeitos desse aumento é um incremento na produtividade primária de algumas espécies vegetais terrestres, que dessa maneira atuam como sequestradoras de carbono. Nos oceanos, o CO2 é armazenado principalmente na forma de carbonato de cálcio (CaCO3), e o aumento na sua concentração leva a uma acidificação da água do mar e a uma menor disponibilidade de íons ca...

  16. The prognostic significance of preoperative serum cancer antigen 15-3 levels in endometrial carcinomas

    Science.gov (United States)

    Tas, Emre E.; Yavuz, Ayse F.

    2017-01-01

    Objectives: To determine the associations between serum cancer antigen 15-3 levels and prognostic factors in patients with endometrial carcinomas. Additionally, we investigated the clinical utility of serum cancer antigen 15-3 levels in the selection of low-risk patients with endometrioid type, tumor size <2 cm, myometrial invasion ≤50%, and histological grade 1-2. Methods: Ninety-six patients, who were surgically staged at Ankara Yildirim Beyazit University, Ankara, Turkey, between 2007 and 2016, were retrospectively analyzed. Demographic, clinical, and surgical characteristics were retrieved from the patients’ hospital records. A p<0.05 was considered significant. Results: Fifteen patients had advanced (≥Stage II) disease, 14 patients had Type 2 histology, 20 patients had Grade 3 tumors, 23 patients had lymphovascular space invasion, and 10 patients had positive lymph node involvement. Serum cancer antigen 15-3 levels were significantly higher in patients with advanced (≥Stage II) disease, Type 2 histology, Grade 3 tumors, lymp°hovascular space invasion, and positive lymph node involvement (p<0.05). Serum cancer antigen 15-3 levels were also significantly correlated with tumor size (p=0.006). Serum cancer antigen 15-3 levels were significantly lower (95% confidence interval: 0.57−0.79; p=0.03) in low-risk patients compared to other endometrial carcinoma patients. A cutoff of 25.0 IU/mL was used to identify high-risk patients with a specificity of 100%. Conclusion: Serum cancer antigen 15-3 levels significantly correlated with prognostic factors and were a useful diagnostic tool for endometrial carcinomas. PMID:29114696

  17. The prognostic significance of preoperative serum cancer antigen 15-3 levels in endometrial carcinomas

    Directory of Open Access Journals (Sweden)

    Emre E. Tas

    2017-11-01

    Full Text Available Objectives: To determine the associations between serum cancer antigen 15-3 levels and prognostic factors in patients with endometrial carcinomas. Additionally, we investigated the clinical utility of serum cancer antigen 15-3 levels in the selection of low-risk patients with endometrioid type, tumor size less than 2 cm, myometrial invasion ≤50%, and histological grade 1-2. Methods: Ninety-six patients, who were surgically staged at Ankara Yildirim Beyazit University, Ankara, Turkey, between 2007 and 2016, were retrospectively analyzed. Demographic, clinical, and surgical characteristics were retrieved from the patients’ hospital records. A p less than 0.05 was considered significant. Results: Fifteen patients had advanced (≥Stage II disease, 14 patients had Type 2 histology, 20 patients had Grade 3 tumors, 23 patients had lymphovascular space invasion, and 10 patients had positive lymph node involvement. Serum cancer antigen 15-3 levels were significantly higher in patients with advanced (≥Stage II disease, Type 2 histology, Grade 3 tumors, lymphovascular space invasion, and positive lymph node involvement (p less than 0.05. Serum cancer antigen 15-3 levels were also significantly correlated with tumor size (p=0.006. Serum cancer antigen 15-3 levels were significantly lower (95% confidence interval: 0.57−0.79; p=0.03 in low-risk patients compared to other endometrial carcinoma patients. A cutoff of 25.0 IU/mL was used to identify high-risk patients with a specificity of 100%. Conclusion: Serum cancer antigen 15-3 levels significantly correlated with prognostic factors and were a useful diagnostic tool for endometrial carcinomas.

  18. Mechanical Tensile Testing of Titanium 15-3-3-3 and Kevlar 49 at Cryogenic Temperatures

    Science.gov (United States)

    James, Bryan L.; Martinez, Raul M.; Shirron, Peter; Tuttle, Jim; Galassi, Nicholas M.; Mcguinness, Daniel S.; Puckett, David; Francis, John J.; Flom, Yury

    2011-01-01

    Titanium 15-3-3-3 and Kevlar 49 are highly desired materials for structural components in cryogenic applications due to their low thennal conductivity at low temperatures. Previous tests have indicated that titanium 15-3-3-3 becomes increasingly brittle as the temperature decreases. Furthermore, little is known regarding the mechanical properties of Kevlar 49 at low temperatures, most specifically its Young's modulus. This testing investigates the mechanical properties of both materials at cryogenic temperatures through cryogenic mechanical tensile testing to failure. The elongation, ultimate tensile strength, yield strength, and break strength of both materials are provided and analyzed here.

  19. Mechanical characterization and structural of Mg{sub 70}Zn{sub 28}Ca{sub 2} alloy for use as bioabsorbable implants; Caracterizacao mecanica e estrutural de uma liga Mg{sub 70}Zn{sub 28}Ca{sub 2} para uso como implante bioabsorvivel

    Energy Technology Data Exchange (ETDEWEB)

    Asato, G.H.; Matias, T.B.; Kiminami, C.S.; Botta, W.J.; Bolfarini, C., E-mail: asato.hitoshi@gmail.com [Universidade Federal de Sao Carlos (UFSCar), SP (Brazil)

    2014-07-01

    A ternary magnesium-based alloy was studied for your biocompatibility, high mechanical properties, elastic modulus close to the bone and corrosion rate less than pure magnesium. The experimental conditions enabled to process a Mg70Zn28Ca2 ternary amorphous alloy by the fusion of eutectic binary alloys (Mg-Zn and Mg-Ca), which were obtained from pure elements in a induction furnace in an argon atmosphere. The characterization of alloy involved quantitative chemical analysis, X-ray diffraction (XRD), scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). The results indicated that the actual composition was very close to the nominal, with the presence of amorphous up to 1.3 mm thick. The mechanical compression test was performed in the conventional cylindrical samples with a diameter of 3 mm on an Instron type machine, obtaining the compressive strength above 400 MPa. (author)

  20. Esferas (beads de alginato como agente encapsulante de óleo de croton zehntneri Pax et Hoffm ALG/Ca beads as an encapsulation agent of croton zehntneri Pax et Hoffm essential oil

    Directory of Open Access Journals (Sweden)

    Haroldo C. B. de Paula

    2010-06-01

    Full Text Available Esferas de alginato (ALG reticuladas com cálcio e revestidas com goma do cajueiro (GC foram preparadas e dopadas com óleo essencial de Croton zehntneri Pax et Hoffm (Cz, visando a seu emprego como larvicida para combate ao vetor da dengue. As esferas foram caracterizadas estruturalmente por espectroscopia de infravermelho, análise térmica, microscopia eletrônica de varredura e em relação aos seus parâmetros de transporte líquido, dopagem, embebição (Q e cinética de liberação in vitro e in vivo. Os resultados revelaram que as esferas possuem morfologia com uma alta regularidade esférica, com superfície porosa. A matriz ALG:Cz =1:1 apresentou maior dopagem e eficiência de encapsulamento e valores de Q entre 10 e 12. O perfil de liberação do óleo encapsulado apresentou-se mais prolongado nas esferas contendo goma do cajueiro, ALG-GC:Cz =1:1. A taxa de mortalidade de larvas de Stegomyia aegypti para teores de 1,81 a 4,25 mg de óleo nas esferas resultou em valores na faixa de 72 a 100%, após 24 h. A matriz polimérica mostrou-se efetiva para proteção do principio ativo até cerca de 70 dias, com perdas da ordem de 35%. A análise térmica revelou que a incorporação de Cz e GC resulta em uma matriz polimérica termicamente mais estável.Alginate beads (ALG crosslinked with calcium and coated with cashew gum (GC were prepared and loaded with an essential oil from Croton zehntneri Pax et Hoffm (Cz. The beads were characterized by FTIR, thermal properties, with respect to their size, shape, larvicide loading, swelling, and in vitro and in vivo release kinetics. Results showed that beads with ALG:Cz =1:1 relative ratio showed higher loading and encapsulation efficiency, although presenting a faster release kinetics. On the other hand, ALG beads coated with GC showed Q values from 10 to 12, representing a significant increase in the hydrophilic character of the matrix. Infrared spectroscopy and thermal analysis confirmed the

  1. Sugarcane Molasse and Whey as Additives in the Silage of Lemongrass (Cymbopogon citratus [DC.] Stapf Leaves Melaza de Caña de Azúcar y Suero de Leche como Aditivos en el Ensilaje de Hojas de Zacate de Limón (Cymbopogon citratus [DC.] Stapf

    Directory of Open Access Journals (Sweden)

    Lucía María Cristina Ventura-Canseco

    2012-03-01

    Full Text Available After extraction of essential oil from lemongrass (Cymbopogon citratus [DC.] Stapf leaves by steam distillation (heat treatment, large amounts of organic wastes are obtained. This by-product could easily be used as animal feed. The potential of sugarcane molasse and whey as additives to ensile lemongrass leaves was investigated. The vegetative material was obtained after essential oils were extracted from lemongrass leaves with steam distillation. Lemongrass leaves were chopped, mixed with sugarcane molasse and whey, placed in cylindrical plastic containers, hermetically closed. The experimental design for pH optimization was a response surface 3-level factorial design 3² with three replicates. Sugarcane molasse at 5, 10 and 15% (w/w and whey at 20, 25 and 30% (w/w were used. The pH of the silage decreased significantly in each treatment, but it was faster when sugarcane molasse was added. The lactic acid concentration was 2.8 g kg-1 DM in silage amended with 15% molasse plus 25% whey and was higher than in silage supplemented with commercial additive after 15 d. In conclusion, it was shown that lemongrass leaves obtained as by product after extracting essential oils can be effectively ensiled with whey and sugarcane molasse as additives inducing a faster production of lactic acid.Después de la extracción del aceite esencial de zacate limón (Cymbopogon citratus [DC.] Stapf por destilación con vapor (tratamiento térmico se obtiene un residuo. Este residuo podría ser utilizado para alimentación animal. El potencial de la melaza de caña y suero de leche como aditivos para ensilar hojas de zacate limón fue investigado. El material vegetal se obtuvo después que los aceites esenciales se extrajeron de las hojas de zacate limón usando destilación con vapor. Las hojas de zacate limón se picaron, mezclaron con melaza de caña y suero de leche y se colocaron en recipientes cilíndricos de plástico y se cerraron herméticamente. El dise

  2. 25 CFR 15.3 - Who can make a will disposing of trust or restricted land or trust personalty?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Who can make a will disposing of trust or restricted land or trust personalty? 15.3 Section 15.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR... Introduction § 15.3 Who can make a will disposing of trust or restricted land or trust personalty? Any person...

  3. Subtelomeric deletion of chromosome 10p15.3: clinical findings and molecular cytogenetic characterization.

    Science.gov (United States)

    DeScipio, Cheryl; Conlin, Laura; Rosenfeld, Jill; Tepperberg, James; Pasion, Romela; Patel, Ankita; McDonald, Marie T; Aradhya, Swaroop; Ho, Darlene; Goldstein, Jennifer; McGuire, Marianne; Mulchandani, Surabhi; Medne, Livija; Rupps, Rosemarie; Serrano, Alvaro H; Thorland, Erik C; Tsai, Anne C-H; Hilhorst-Hofstee, Yvonne; Ruivenkamp, Claudia A L; Van Esch, Hilde; Addor, Marie-Claude; Martinet, Danielle; Mason, Thornton B A; Clark, Dinah; Spinner, Nancy B; Krantz, Ian D

    2012-09-01

    We describe 19 unrelated individuals with submicroscopic deletions involving 10p15.3 characterized by chromosomal microarray (CMA). Interestingly, to our knowledge, only two individuals with isolated, submicroscopic 10p15.3 deletion have been reported to date; however, only limited clinical information is available for these probands and the deleted region has not been molecularly mapped. Comprehensive clinical history was obtained for 12 of the 19 individuals described in this study. Common features among these 12 individuals include: cognitive/behavioral/developmental differences (11/11), speech delay/language disorder (10/10), motor delay (10/10), craniofacial dysmorphism (9/12), hypotonia (7/11), brain anomalies (4/6) and seizures (3/7). Parental studies were performed for nine of the 19 individuals; the 10p15.3 deletion was de novo in seven of the probands, not maternally inherited in one proband and inherited from an apparently affected mother in one proband. Molecular mapping of the 19 individuals reported in this study has identified two genes, ZMYND11 (OMIM 608668) and DIP2C (OMIM 611380; UCSC Genome Browser), mapping within 10p15.3 which are most commonly deleted. Although no single gene has been identified which is deleted in all 19 individuals studied, the deleted region in all but one individual includes ZMYND11 and the deleted region in all but one other individual includes DIP2C. There is not a clearly identifiable phenotypic difference between these two individuals and the size of the deleted region does not generally predict clinical features. Little is currently known about these genes complicating a direct genotype/phenotype correlation at this time. These data however, suggest that ZMYND11 and/or DIP2C haploinsufficiency contributes to the clinical features associated with 10p15 deletions in probands described in this study. Copyright © 2012 Wiley Periodicals, Inc.

  4. TUBERCULOSIS COMO ENFERMEDAD OCUPACIONAL

    Science.gov (United States)

    Mendoza-Ticona, Alberto

    2014-01-01

    Existe evidencia suficiente para declarar a la tuberculosis como enfermedad ocupacional en diversos profesionales especialmente entre los trabajadores de salud. En el Perú están normados y reglamentados los derechos laborales inherentes a la tuberculosis como enfermedad ocupacional, como la cobertura por discapacidad temporal o permanente. Sin embargo, estos derechos aún no han sido suficientemente socializados. En este trabajo se presenta información sobre el riesgo de adquirir tuberculosis en el lugar de trabajo, se revisan las evidencias para declarar a la tuberculosis como enfermedad ocupacional en trabajadores de salud y se presenta la legislación peruana vigente al respecto. PMID:22858771

  5. Comparative study on the adsorption of Co{sup 2+} on CaCO{sub 3} compounds used as adsorbents; Estudio comparativo sobre la adsorcion de Co{sup 2+} sobre compuestos de CaCO{sub 3} utilizados como adsorbentes

    Energy Technology Data Exchange (ETDEWEB)

    De Jesus V, S.

    2014-07-01

    The calcium carbonate (CaCO{sub 3}) was synthesized by methods of precipitation, calcination, sol-gel and trigonal/sol-gel. These materials were characterized by the techniques of X-ray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, infrared spectroscopy and N{sub 2} physisorption measurements in order to identify their textural, surface and structural properties. The results show that the material synthesized by sol-gel had the highest surface area of 39.5230 m{sup 2}/g, and a total pore volume of 0.0484 m{sup 3}/g and a pore diameter of 4.9050 nm. The synthesized materials were used to comparatively study their adsorption capacity of Co{sup 2+} ions present in aqueous solutions, by experiments batch or batch type at an ambient temperature (25 grades C) and to 4 hours, balance time established previously under an adsorption kinetic study. They found as maximum adsorption capacities of Co{sup 2+} in materials of 1.8582 mg/g for the calcium carbonate obtained by precipitation, of 0.8586 mg/g for the material obtained by calcining, of 3.1895 mg/g for the material obtained by sol-gel and finally of 2.5783 mg/g for the material obtained by the trigonal/sol-gel method, therefore it follows that the material having the highest adsorption capacity of Co{sup 2+} ions was synthesized by the sol-gel method, because it showed better surface, textural and structural properties compared to other materials studied. (Author)

  6. CARCINOMA-ASSOCIATED MUCIN SERUM MARKERS CA-M26 AND CA-M29 - EFFICACY IN DETECTING AND MONITORING PATIENTS WITH CANCER OF THE BREAST, COLON, OVARY, ENDOMETRIUM AND CERVIX

    NARCIS (Netherlands)

    YEDEMA, KA; KENEMANS, P; WOBBES, T; VANKAMP, GJ; DEBRUIJN, HW; THOMAS, CM; MASSUGER, LF; SCHIJF, CP; BON, GG; VERMORKEN, JB; VOORHORST, F; HILGERS, J

    1991-01-01

    Two recently developed monoclonal antibody (MAb)-based anti-mucin assays, CA M26 and CA M29, were studied in 250 cancer patients and compared to 3 well-established marker tests, viz., CA 125, CA 15.3 and SCC, in order to assess their clinical usefulness as serum tumor markers. Pre-treatment sera

  7. Hoy como ayer

    OpenAIRE

    Rodríguez M.

    2010-01-01

    Leyendo el artículo titulado “Los medicamentos baratos” de la revista La Farmacia Española, publicada en Madrid el jueves 21 de diciembre de 1893, uno se pregunta cómo puede ser que se reconozca la situación como si fuera de ahora mismo, cómo puede ser que estemos igual que hace más de cien años. Entonces eran los descuentos que se empezaban a extender en las farmacias, francesas sobre todo, y que amenazaban el prestigio profesional de todo el colectivo. Con frases como éstas se define la sit...

  8. La razonabilidad como virtud

    OpenAIRE

    Muñoz Oliveira, Luis Humberto

    2008-01-01

    Consultable des del TDX Títol obtingut de la portada digitalitzada Esta tesis doctoral explora la idea de que la razonabilidad es una virtud fundamental para que las sociedades plurales puedan convertirse en, o mantenerse como, un sistema de cooperación donde la justicia sea posible. La hipótesis central es que la razonabilidad como virtud es una manera de ser tolerante de forma solidaria, es entender al conciudadano, escucharlo, saber que juntos acordaron las reglas de cooperación y ac...

  9. Extremely Elevated CA 125 and CA 19-9 in Endometrioma; A Case Series

    Directory of Open Access Journals (Sweden)

    Vugar Bayramov

    2010-03-01

    Full Text Available Although endometriosis is a benign condition, increased levels of the tumor markers CA 125 and CA 19-9 may be seen. However, these tumor markers reach to very high levels, rarely. In this report, 4 patients between 20 and 43 year-old with extremely elevated CA 125, CA 19-9 and CA 15-3 levels are discussed. In endometriosis extremely increased tumor markers are determined in the case of ruptured endometrioma cyst. There are two mechanisms to clarify extremely elevated levels of CA 125 in endometriosis. First, the peritoneal irritation of CA 125 molecule after the rupture of endometioma cyst and CA 125 secretion from the periton. And the second is penetration of the CA 125 moecule easily to the circulation through the peritoneal endothelial surface after the cyst rupture. In conclusion, the diagnosis of ruptured endometrioma cyst should be kept in mind especially in young patients with extremely elevated serum CA 125 levels with regard to the history and ultrasonographical signs and invasive procedures should be avoided.

  10. Implementing SDG 15.3 on Land Degradation Neutrality in the EU and EU Member States

    Science.gov (United States)

    Wunder, Stephanie; Starke, Sue Martina; Frelih-Larsen, Ana; Kaphengst, Timo

    2017-04-01

    The continuing degradation of land and soils is a severe threat to the provision of ecosystem services and economic development. Sustainable use of land and soils are therefore an integral part of the "Agenda 2030" with its 17 Sustainable Development Goals (SDGs) and 169 targets adopted by the UNGeneral Assembly in September 2015. The SDGs provide new opportunities for an ambitious and integrated environmental policy worldwide and in the EU. Among the many relevant targets that directly or indirectly address soils (such as goals on zero hunger, well being, clean energy, climate change, water and sustainable cities), target 15.3 that aims to achieve "a land degradation-neutral world" by 2030 is the most relevant. The concept of "Land Degradation Neutrality" (LDN) is not only about halting the loss of healthy and fertile land, but also actively reversing degradation by restoring land in order to counterbal-ance losses that cannot be avoided. It is a very ambitious target but due to a lack of balancing mechanisms for degradation and restoration in most countries also a new concept. Land Degra-dation Neutrality therefore both needs a scientific conceptual framework as well as a political debate about its implementation and development of instruments. In the EU and its Member States, this debate can also serve as a catalyst to revive the discussion on a common soil policy in Europe after the withdrawal of the proposal for a soil framework directive in 2014. To analyze options for the implementation of target 15.3 in Germany and Europe the research project "Implementing the Sustainable Development Goals on Soils in Germany" (http://ecologic.eu/12876) is currently carried out by the Ecologic Institute on behalf of the Ger-man Environment Agency (UBA) and the German Federal Environment Ministry (BMUB). The project will run until spring 2017 and the session "European Environmental Policies and Sustainability" at the EGU will be an ideal opportunity to present the final

  11. Ouabaina como Hormona

    OpenAIRE

    J. Hernando Ordoñez

    1996-01-01

    Comentario sobre su origen endógeno y sus aplicaciones terapéuticas

    Pocas drogas han sido más estudiadas que el grupo de los digitálicos, estrofantinas y ouabaina, cuyo estudio es objeto del presente trabajo.

    La ouabaina empezó a ser estudiada desde el siglo pasado. La primera referencia conocida corresponde a Pelikan, 1865 (1), como veneno que empleaban para las flechas en Gabón (Africa). (.)

  12. Hoy como ayer

    Directory of Open Access Journals (Sweden)

    Rodríguez M.

    2010-06-01

    Full Text Available Leyendo el artículo titulado “Los medicamentos baratos” de la revista La Farmacia Española, publicada en Madrid el jueves 21 de diciembre de 1893, uno se pregunta cómo puede ser que se reconozca la situación como si fuera de ahora mismo, cómo puede ser que estemos igual que hace más de cien años. Entonces eran los descuentos que se empezaban a extender en las farmacias, francesas sobre todo, y que amenazaban el prestigio profesional de todo el colectivo. Con frases como éstas se define la situación que se presentaba en aquel momento: “…el desprestigio de que vaya por unos cuantos desnaturalizándose el ejercicio de la farmacia en tal forma que se convierta en un comercio impuro y de la peor estofa; pero conviene mucho combatir con mano firme la tendencia a la baratería, tanto más cuanto que no puede dudarse que significa un rebajamiento a todas luces nocivo y que supone una desorganización que nos llevaría en breve a la más completa ruina, y lo que creo aún más grave, a la desmoralización y el desorden, que no se compadecen en modo alguno con lo que en realidad es hoy y ha sido siempre el ejercicio de una profesión genuinamente científica como lo es la de la farmacia”. La propuesta que se hacía para controlar la situación era “la limitación de farmacias, con vigilancia estrecha del Estado y tarifa uniforme oficial”, así como “hace falta mucha inteligencia y mucha unión, hace falta que nadie permanezca indiferente, que todos y cada uno pongan de su parte lo que puedan”. Nuestra profesión mezcla una doble vertiente sanitaria y comercial que no siempre es fácil mantener equilibrada y, por lo que se ve, esto ha ocurrido así desde siempre. El problema que existe hoy en día es la mercantilización de la farmacia, un desplazamiento de establecimiento sanitario hacia una simple empresa.

  13. O ensaio como narrativa

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    Pedro Duarte

    2016-02-01

    Full Text Available O artigo tenta demonstrar que todos os textos, mesmo aqueles cuja natureza é teórica, têm alguma forma de narrativa. Nem sempre são personagens que os ocupam, podem ser ideias, mas mesmo assim há um enredo conceitual que se passa. Modernamente, a forma dessa narrativa foi sobretudo o sistema, com a pretensão totalizadora presente, por exemplo, na filosofia de Hegel. Contemporaneamente, porém, a forma do ensaio – surgida ainda na era moderna – ganha destaque por sua forma descontínua de narrar. O objetivo do artigo é apontar que, se o ensaio é uma forma, como explicitaram Lukács, Benjamin e Adorno, ele é também uma forma de narrar – ainda que de narrar conceitualmente objetos da cultura.

  14. La Justicia como virtud

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    Martínez-Sicluna y Sepúlveda, Consuelo

    2003-07-01

    Full Text Available El sentimiento de la justicia representa el hábito de conducta por el que nos vemos obligados, en cualquier relación, a dar a cada uno lo suyo. Ahora bien, esta disposición del espíritu se inscribe en las coordenadas que definen al hombre: verdad, libertad y bien. El hombre como ser racional y por tanto libre: el único ser que se determina a sí mismo y que alcanza en el bien el sentido de su proyección personal, esto es, la perfección. Dar a cada uno lo suyo es dar al sujeto el reconocimiento de este fundamento ontológico.

  15. Como comunicar la Alegria

    Directory of Open Access Journals (Sweden)

    Pablo Portales

    2015-01-01

    Full Text Available Se ofrece un amplio análisis sobre la industria electoral, recordando que un candidato a presidente es "un producto para la venta". Se Desmenuzan las estrategias utilizadas en el plebiscito chileno,las elecciones norteamericanas con el NO a BUSH. El Mercadeo Social es una nueva metodología utilizada en proyectos de desarrollo a nivel de campo por ello se hace un esclarecimiento y clarifica el vínculo con la comunicación. Se agrega temas como: Los modelos de recepción de mensajes cuyos marcos conceptuales y metodologías aún no se han adaptado al potencial de esta línea de trabajo.Se analiza la agonía de las radios mineras en Bolivia en la que 42 años de historia y heroísmo se desmoronan.

  16. El inquisidor como profesor

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    Adriano PROSPERI

    2009-12-01

    Full Text Available Giovanni Botero, en una célebre página de su Ragion di stato, se detuvo sobre el tema de la fuerza de la religión en los gobiernos. Esta función de la religión cristiana —para Botero, católica— es garante del orden público y se presenta también como opuesta a la generadora de desorden de Lutero y Calvino, quienes siembran por todo cizañas y revoluciones de estados y ruinas de los reinos. Estamos en los orígenes del esquema historiografía de la periodización de la Edad Moderna que confió precisamente a la Reforma el papel de nodriza de las revoluciones que nacieron en Europa.

  17. La persona como creatura

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    Emmanuel Housset

    2010-01-01

    Full Text Available El artículo de Emmanuel Housset implica un esfuerzo de rehabilitación del concepto «persona» para la filosofía contemporánea y la fenomenología. Para ello el autor busca mostrar cómo poco a poco «persona» tomó otra significación que la de «personaje» o sujeto de derecho. Es en autores como san Agustín y santo Tomás de Aquino que se halla un acceso diferente que pone el énfasis más bien en su carácter relacional y responsivo de la persona, antes que en su dimensión autónoma y autotélica. Tal dimensión aparece, según Housset, junto con la idea de persona como creatura y en oposición a la de individuo racional dueño de sí. La dimensión afectiva, la personalidad despertada por las diversas figuras de la alteridad son algunas de las dimensiones de la persona que examina el autor a partir del examen de la carne, las pasiones, la memoria, la historicidad y el amor alteridad.Emmanuel Housset's paper is an effort to revitalize the concept of 'person' for contemporary philosophy and phenomenology To this end the author looks to show how little by little the understanding of 'person' took on a different meaning to that of 'character' or "right bearing individual". It is in authors such as St. Augustine and St. Thomas Aquinas that a different approach is found, one that puts emphasis on the relational and responsive character of a person, rather than on the autonomous and auto telic dimension. According to Housset, such a dimension appears together with the idea of the person as a creation, and in opposition to the idea of the rational individual, that is his own master. The emotional dimension and the personality that is awoken by the many figures of alterity are some of the dimensions of the person that the author analyzes, based on examining the flesh, passions, memory historicity and love.

  18. El signo como emblema

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    Sáez, Carlos

    2003-06-01

    Full Text Available The aim of this article is to study the signs and symbols that appear in the hispanic medieval documents and manuscripts. These signs and symbols have usually been considered simply as mere elements to validate the charters. However, these alements were useful as a mean of visual communication between the high classes, able to generate charters, and the rest of medieval society—the majority illiterate— who received those charters. Because of their inability of understand an alphabetical code, they needed the graphic help to comprehend the message. Besides this, the article deals with non diplomatic signs and their function.

    Este artículo se centra en los signos o símbolos presentes en los documentos y manuscritos medievales hispanos, que habitualmente han sido tratados como meros elementos de validación de los diplomas. Pero estos elementos servían también de nexos de comunicación visual entre las clases poderosas, capaces de producir escritos, y los demás miembros de la sociedad medieval, receptores y destinatarios de tales escritos, en su mayoría analfabetos. Precisamente por esta razón, su incapacidad de descifrar un código alfabético, necesitan de auxilio gráfico para acercarse a la comprensión del mensaje. Asimismo, tratamos de los signos no diplomáticos y de su función.

  19. O analista como testemunha

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    Jô Gondar

    2016-04-01

    Full Text Available Resumo A proposta deste artigo é pensar o lugar da testemunha como um lugar terceiro que o analista, na clínica do traumático, é capaz de sustentar. Nos sonhos traumáticos, segundo Ferenczi, já existe a convocação de um terceiro. Não se trata da testemunha da esfera do Direito, tampouco do lugar do pai ou da Lei simbólica. Trata-se de um terceiro espaço que pode ser chamado de potencial, espaço intersticial, indeterminado e informe no qual circula - e aos poucos ganha forma -, algo que a princípio seria incomunicável. Esse espaço permite e suporta a literalidade da narrativa testemunhal, seus titubeios, paradoxos e silêncios. Mais do que uma teoria do trauma, a noção de espaço potencial seria a grande contribuição da psicanálise às pesquisas teóricas e clínicas com sobreviventes de campos de extermínio, de situações de tortura e de violência.

  20. Arte como espelho

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    Pedro Süssekind

    2016-12-01

    Full Text Available Este artigo tem como ponto de partida o exemplo da relação espelhada entre um livro e uma pintura de mesmo nome: o retrato que Lucian Freud fez do crítico de arte Martin Gayford e o diário que esse crítico escreveu sobre seu retratista, ambas as obras chamadas Homem com cachecol azul. A partir do exemplo, discuto a metáfora do espelho para caracterizar a arte, recorrendo para isso à teoria da representação artísticas elaborada pelo filósofo norte-americano Arthur Danto no artigo “O mundo da arte”, de 1964, e no primeiro capítulo do livro A transfiguração do lugar-comum, de 1981. Recorro, por fim, a dois exemplos artísticos de espelhamento na representação analisados por Danto em O abuso da beleza, de 2003, um quadro holandês do século dezessete e um poema de Rainer Maria Rilke.

  1. El riesgo como oportunidad

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    Daniela Gargantini

    2003-01-01

    Full Text Available Durante los últimos años el crecimiento mundial de catástrofes naturales ha ido en franco aumento. Sin embargo, desde un enfoque sistémico puede verificarse que la gran mayoría de los desastres se origina en los países en desarrollo (entre ellos los latinoamericanos, siendo las pérdidas en ellos significativamente más altas que en los países industrializados. Bajo esta postura los desastres no son sólo naturales sino socio- naturales, enfatizando la estrecha relación de causalidad entre modelos de desarrollo y urbanización y procesos de generación de riesgos, al incrementar la vulnerabilidad de los sectores más desprotegidos. El desastre pone en evidencia así una situación (la pobreza y segregación urbana ya existente, pero no considerada hasta el momento de la catástrofe. Frente a este panorama el desastre aparece como oportunidad que precipita tres catalizadores de políticas habitacionales: tierra, asistencia técnica y financiamiento, incrementando la celeridad y la creatividad de las respuestas. El interrogante que surge es por qué esperar el desastre para ponerlos en marcha, cuando ninguno de ellos es estrictamente dependiente de la situación de riesgo, sino sujeto de luchas de poder.

  2. Endomarketing: como diferencial competitivo

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    Karin Birck

    2013-05-01

    Full Text Available Atualmente, com a profissionalização das empresas e com a grande concorrência no mercado, observa-se uma demanda cada vez maior de gestores comprometidos com o bem-estar pessoal e profissional de seus colaboradores. E, com esse intuito, de apresentar algumas idéias básicas de gestão voltadas à aplicação nas mais diversas técnicas de Endomarketing. Demonstra assim, a importância da utilização de feedback, tanto por parte dos colaboradores quanto dos gestores, destacando a importância de trabalhos de motivação, do clima organizacional favorável e de uma comunicação interna eficaz e a necessidade ímpar de tratar o colaborador como o diferencial dentro de uma empresa. Desta forma, foi realizada uma pesquisa bibliográfica que auxiliará e dará subsídios que lhe permitam retribuir em ações e atitudes de sucesso e, também, fazer um confronto de idéias, onde os autores apresentam suas mais diversas opiniões. Contudo, valendo-se, muitas vezes, de narrativas de experiências de outros gestores e até mesmo de suas próprias, tirando cada um suas próprias conclusões.

  3. Ouabaina como Hormona

    Directory of Open Access Journals (Sweden)

    J. Hernando Ordoñez

    1996-04-01

    Full Text Available

    Comentario sobre su origen endógeno y sus aplicaciones terapéuticas

    Pocas drogas han sido más estudiadas que el grupo de los digitálicos, estrofantinas y ouabaina, cuyo estudio es objeto del presente trabajo.

    La ouabaina empezó a ser estudiada desde el siglo pasado. La primera referencia conocida corresponde a Pelikan, 1865 (1, como veneno que empleaban para las flechas en Gabón (Africa. (.

    (. Vinieron luego los trabajos de Fraser, 1869, (2, 3, 6, Polaillon, 1871 (4, Amaud, 1888 (5, Vaquez y Lutembacher, 1917 (7, Stoll, 1939 (8, Lapicque, 1929 (9, Wiggers, 1927 (10, Ytantos otros (11, 12, 13. En la obra de Kisch (14 aparecen más de 700 referencias bibliográficas sobre el particular.

    Ouabaina de origen endógeno. Purificación
    Durante muchos años se conoció la ouabaina como de origen vegetal, elaborada por las plantas Strophanthus Glaber(k-estrofantina,AcocantheraOuabaio(Ouabaina yStrophanthus Kombe (k-estrofantina y kestrofantósido. Una propiedad común a todos los digitálicos, estrofantina y ouabaina es que todos son inhibidores de la bomba de Na-K, encargada de regular la salida de Na y la entrada de K celular.

    Estudiando los inhibido res de esta bomba han encontrado en años recientes resultados extraordinarios en relación con el origen endógeno de algunos de estos inhibidores, entre ellos la ouabaina. Por considerarlos de extrema importancia y actualidad científica me permito citar algunos de ellos. Hamlyn y Manunta (15, 16, 17, 18, Y 19 hicieron estudios sobre el particular y lograron identificar en el plasma humano un compuesto igual a la ouabaina. Estos hallazgos fueron confirmados después por otros autores (20, 21, 22, 23 Y24.

    Ham bl yn (19 da varios argumentos que ponen en evidencia que el compuesto químico encontrado es ouabaina pura, y, lo que es más interesante, que tiene un origen endógeno. a Por espectroscopia de alta resoluci

  4. O direito como imperativo

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    Cloter Miglioriani

    1988-08-01

    Full Text Available We have examined one of the facets which Law presents to society, looking at the theme through a brief history of Law, in which Roman Law stands out, up to modem times, comparing current juridical systems such as the Continental System, Common Law, and Soviet Law. We have looked at Law from the viewpoint of society 's need to have basic mies for living together, with the juridical ruZe being one of the most important. We have highlighted the views of Hart and Kelsen on the foundations of the validity of Law. We have also considered the obligatoriness of Law; giving the point of view of tadbruch who, explaining his ''Theory of the Obligatoriness of Law ", concluded that the obligatoriness of Law can only be withdraw when there is a Clash between morals, law, use and social conventions. We have looked at the notion of the imperativeness of Law the central theme of the work -drawing on the views of Miguel Reale, for whom the juridical nonn cannot be reduced to a "command of a volitional nature", but rather the obligatory character of the juridical nonn arises from the pressure of social values. Del Vecchio, who is also quoted, recognized that imperativeness exists in the juridical norm, whether it is preceptive (a positive command or permissive. Also mentioned is the opinion of Tercio Sampaio Ferraz, for whom the juridical norm has imperativeness to the extent that the imposition of behaviour is unconditionally guaranteed. Foi feita a abordagem de uma das facetas com que o Direito se apresenta à sociedade, enfocando o tema a partir de um brevíssimo histórico do Direito, onde revela a fase romana, até os períodos modernos, com comparações dos sistemas jurídicos hodiernos, como o sistema continental, o da Commum Law e o soviético. Foi enfocado o Direito em face da necessidade sociedade em ter básicas de convivência, despontando a regra jurídica como das mais importantes. Foi dado destaque às posições de Hart e Kelsen, sobre os

  5. Producción de endoproteasa ácida extracelular (mrAE) por el hongo fitopatógeno Moniliophthora roreri cultivado en el sistema de fermentación en el estado sólido con bagazo de caña de azúcar como sustrato.

    OpenAIRE

    Soberano Mayo, María Isabel

    2012-01-01

    Las proteasas son enzimas industriales muy importantes y comprenden alrededor del 60% de las enzimas comerciales en el mundo. Dos terceras partes de estas proteasas son de fuentes microbianas, principalmente de origen fúngico. El presente trabajo tuvo como objetivos estudiar la cinética de producción de enzima endoproteasa ácida extracelular (mrAe) del hongo fitopatógeno Moniliophthora roreri MRO1, cultivado en sistema de fermentación en estado sólido (FES), utilizando como sustrato inductor ...

  6. Impact of seawater [Ca

    NARCIS (Netherlands)

    Mewes, A.; Langer, G.; Thoms, S.; Nehrke, G.; Reichart, G.J.; de Nooijer, L.J.; Bijma, J.

    2015-01-01

    Mg / Ca ratios in foraminiferal tests are routinely used as paleotemperature proxies, but on long timescales, they also hold the potential to reconstruct past seawater Mg / Ca. The impact of both temperature and seawater Mg / Ca on Mg incorporation in Foraminifera has been quantified by a number of

  7. Europa como cultura

    Directory of Open Access Journals (Sweden)

    Javier San Martín

    2012-02-01

    Full Text Available El presente texto tiene un origen muy concreto. El día 15 de marzo de 2002, con motivo de la Cumbre Europea de Barcelona, Jorge Semprún reflexionaba, en las páginas de un conocido diario madrileño, sobre el significado que para él tenía ser europeo. Para ello emprendía tres "viajes intelectuales" a Viena, Praga y Buchenwald, los tres de gran significado histórico y cultural. Dado el interés del texto y del momento, me pareció entonces oportuno glosar algunos aspectos de aquel artículo, primero, para subrayar el valor de la aportación de Semprún, luego para corregir alguna inexactitud de carácter biográfico, debida posiblemente a la rapidez de la traducción, y, tercero, para ampliar con algún comentario la valiosa contribución de Sempnín, sobre todo en lo que concierne al sentido de Europa. En este texto se toma aquel comentario como punto de partida.The origins of this text are very specific. On 15 March 2002, on the occasion of the European Summit in Barcelona, and on the pages of a well-known Madrid newspaper, Jorge Semprún reflected on the meaning that being European had for him. To do this, he embarked on three "intellectual journeys" to Vienna, Prague and Buchenwald, all three of great historical and cultural significance. Given the interest of the text and of the moment, I considered it appropriate to comment on aspects of the article -firstly, to underline the value of Semprún's contribution; secondly, to correct certain biographical inaccuracies, possibly due to a hasty translation; and thirdly, to complement Semprún's valuable contribution, essentially concerning the meaning of Europe. This text takes that comment as its starting point.

  8. El CO2 como disolvente y como reactivo

    OpenAIRE

    La Franca Pitarresi, Vincenzo Rosario

    2016-01-01

    Existen numerosas ventajas asociada con el uso de CO2 , tanto como disolvente que como reactivo, y todas se pueden resumir en cuatro categorías generales: beneficios ambiental, beneficios de salud y seguridad, beneficios en el procedimiento y beneficios químicos. Los procesos que implican el CO2 como disolvente no aumentaría las emisiones de CO2, más bien proporcionaría una oportunidad para el reciclaje de CO2 residual. Además, los esfuerzos para secuestrar el CO2 producido de los gases de co...

  9. Síntese e estudo microestrutural de perovskita do tipo La0,8Ca0,2MO3 (M = Co ou Mn com gelatina como precursor orgânico para aplicação em catálise automotiva Synthesis and microstructural characterization of La0.8Ca0.2MO3 (M = Co or Mn perovskite with gelatin as organic precursor

    Directory of Open Access Journals (Sweden)

    J. B. M. Wanderley

    2013-03-01

    Full Text Available Materiais com estrutura perovskita são potenciais catalisadores para prevenir a emissão de componentes poluentes no meio ambiente. Vários métodos têm sido propostos para a síntese desses materiais visando produzir materiais homogêneos com tamanho de partícula nanométrico. Neste trabalho os compostos manganato de lantânio e cobaltato de lantânio com substituição parcial de cálcio foram sintetizados com gelatina como agente de polimerização, visando sua utilização como catalisadores automotivos. Esse método de síntese foi utilizado porque permite a obtenção de fases cristalinas com pós homogêneos e porosos. Os pós obtidos a 300 ºC/4 h foram calcinados a 700 e 900 ºC/4 h e caracterizados pelas técnicas de análise termogravimétrica, difração de raios X e microscopia eletrônica de varredura. As perovskitas obtidas foram monofásicas, manométricas, porosas e com propriedades adequadas para aplicação em catálise automotiva.Materials with perovskite structure are potential catalysts to prevent emission of pollutants into the environment. Various methods have been proposed for the synthesis of these materials, to produce homogeneous materials with nanoscale particle size. In this work, lanthanum manganate and lanthanum cobaltate compounds with partial substitution of calcium were synthesized using gelatin as a precursor agent, aiming its use as automotive catalysts. This synthesis method was used because it allows the synthesis of crystalline phases with homogeneous and porous powders. The powders obtained at 300 °C/4 h were calcined at 700 and 900 ºC/4 h and were characterized by thermogravimetric analysis, X-ray diffraction and scanning electron microscopy. The obtained perovskites were monophasic, nanometric, porous and with suitable properties for application in automotive catalysis.

  10. Tensile and fracture behavior of boron and carbon modified Ti-15-3 alloys in aged conditions

    Energy Technology Data Exchange (ETDEWEB)

    Sarkar, R., E-mail: rajdeepsarkar@dmrl.drdo.in [Defence Metallurgical Research Laboratory, Kanchanbagh, Hyderabad 500058 (India); Ghosal, P.; Nandy, T.K. [Defence Metallurgical Research Laboratory, Kanchanbagh, Hyderabad 500058 (India); Ray, K.K. [Department of Metallurgical and Materials Engineering, Indian Institute of Technology, Kharagpur 721302 (India)

    2016-02-22

    This work illustrates the effect of boron and carbon addition on the mechanical behavior of a beta Ti alloy, Ti–15V–3Cr–3Al–3Sn (Ti-15-3), in differently aged conditions. The alloys were prepared by consumable vacuum arc melting followed by forging and hot rolling. These were subsequently solution treated and aged at different temperatures above 500 °C for 8 h. Standard tensile and plane strain fracture toughness tests were carried out to understand the mechanical behavior of the alloys and its correlation with the microstructural features characterized by scanning and transmission electron microscopy. Both the boron- and the carbon-containing alloys exhibit improved strength with comparable elongation to failure values as compared to the base Ti-15-3 alloy. The presence of TiB and TiC precipitates in a matrix of fine α with β results in lower fracture toughness (K{sub IC}) in the boron- and carbon-containing alloys as compared to the base alloy. However, at higher aging temperatures K{sub IC} improves due to more tortuous crack path because of the presence of coarse α-phase. An empirical relationship has been proposed correlating K{sub IC} with the volume fraction, size and interspacing of α in these alloys.

  11. crdi.ca

    International Development Research Centre (IDRC) Digital Library (Canada)

    et des enfants d'Afrique. INITIATIVE CONCERTÉE. Innovation pour la santé des mères et des enfants d'Afrique. Centre de recherches pour le développement international. CP Box 8500 Ottawa ON Canada K1G 3H9. Téléphone : +1 613 236 6163 • Télécopieur : +1 613 657 7749 ismea@crdi.ca | www.crdi.ca/ismea crdi.ca.

  12. INTRACELLULAR Ca2+ HOMEOSTASIS

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    Shahdevi Nandar Kurniawan

    2015-01-01

    Full Text Available Ca2+ signaling functions to regulate many cellular processes. Dynamics of Ca2+ signaling or homeostasis is regulated by the interaction between ON and OFF reactions that control Ca2+ flux in both the plasma membrane and internal organelles such as the endoplasmic reticulum (ER and mitochondria. External stimuli activate the ON reactions, which include Ca2+ into the cytoplasm either through channels in the plasma membrane or from internal storage like in ER. Most of the cells utilize both channels/sources, butthere area few cells using an external or internal source to control certain processes. Most of the Ca2+ entering the cytoplasm adsorbed to the buffer, while a smaller part activate effect or to stimulate cellular processes. Reaction OFF is pumping of cytoplasmic Ca2+ using a combination mechanism of mitochondrial and others. Changes in Ca2+ signal has been detected in various tissues isolated from animals induced into diabetes as well as patients with diabetes. Ca2+ signal interference is also found in sensory neurons of experimental animals with diabetes. Ca2+ signaling is one of the main signaling systems in the cell.

  13. A condicionalidade como zona conceitual

    Directory of Open Access Journals (Sweden)

    Taísa Peres de OLIVEIRA

    Full Text Available RESUMO Neste trabalho avaliam-se diferentes padrões de construções condicionais no português a partir dos parâmetros de condicionalidade. O objetivo principal é mostrar como a categoria está internamente organizada não apenas em termos de um núcleo prototípico, mas mostrando como os exemplares mais periféricos se relacionam a ele. As bases teóricas deste trabalho assentam-se sobre concepções funcional-cognitivistas, nos termos de Bybee (2010 e Dancygier (1998, especialmente considerando a relativa instabilidade da gramática e a fluidez da categoria. As reflexões principais apontam a condicionalidade como uma categoria bastante complexa que serve de/como abrigo de múltiplas construções.

  14. Deformation, Failure, and Fatigue Life of SiC/Ti-15-3 Laminates Accurately Predicted by MAC/GMC

    Science.gov (United States)

    Bednarcyk, Brett A.; Arnold, Steven M.

    2002-01-01

    NASA Glenn Research Center's Micromechanics Analysis Code with Generalized Method of Cells (MAC/GMC) (ref.1) has been extended to enable fully coupled macro-micro deformation, failure, and fatigue life predictions for advanced metal matrix, ceramic matrix, and polymer matrix composites. Because of the multiaxial nature of the code's underlying micromechanics model, GMC--which allows the incorporation of complex local inelastic constitutive models--MAC/GMC finds its most important application in metal matrix composites, like the SiC/Ti-15-3 composite examined here. Furthermore, since GMC predicts the microscale fields within each constituent of the composite material, submodels for local effects such as fiber breakage, interfacial debonding, and matrix fatigue damage can and have been built into MAC/GMC. The present application of MAC/GMC highlights the combination of these features, which has enabled the accurate modeling of the deformation, failure, and life of titanium matrix composites.

  15. Montagem e Imagem como Paradigma

    Directory of Open Access Journals (Sweden)

    Cesar Huapaya

    2016-01-01

    Full Text Available O pensar como montagem e imagem tornou-se um método revelador nos processos de estudos práticos e teóricos do artista e dos pesquisadores nos séculos XX e XXI. Este artigo procura articular três formas de pensar por montagem: nas obras de Bertolt Brecht, Sergei Eisenstein e Georges DidiHuberman. O filósofo e historiador da arte Georges Didi-Huberman reinaugura o debate e o exercício de pensar a antropologia da imagem e a montagem como metalinguagem e forma de conhecimento.

  16. La ciudad como ecosistema urbano

    OpenAIRE

    Higueras García, Esther

    2013-01-01

    LA CIUDAD COMO ECOSISTEMA URBANO .- La ecología y los ecosistemas .- El ecosistema urbano, definición, alcance y oportunidad .- El metabolismo urbano .- Los síntomas de la patología urbana .- Los objetivos del nuevo ecosistema urbano .- Las aportaciones de los ecobarrios

  17. Chromosome r(10(p15.3q26.12 in a newborn child: case report

    Directory of Open Access Journals (Sweden)

    Jonasson Jon

    2009-12-01

    Full Text Available Abstract Background Ring chromosome 10 is a rare cytogenetic finding. Of the less than 10 reported cases we have found in the literature, none was characterized using high-resolution microarray analysis. Ring chromosomes are frequently unstable due to sister chromatid exchanges and mitotic failures. When mosaicism is present, the interpretation of genotype-phenotype correlations becomes extremely difficult. Results We report on a newborn girl with growth retardation, microcephaly, congenital heart defects, dysmorphic features and psychomotor retardation. Karyotyping revealed a non-mosaic apparently stable ring chromosome 10 replacing one of the normal homologues in all analyzed metaphases. High-resolution oligonucleotide microarray analysis showed a de novo approximately 12.5 Mb terminal deletion 10q26.12 -> qter and a corresponding 285 kb terminal deletion of 10pter -> p15.3. Conclusion This case demonstrates that an increased nuchal translucency thickness detected by early ultrasonography should preferably lead to not only QF-PCR for the diagnosis of Down syndrome but also karyotyping. In the future, microarray analysis, which needs further evaluation, might become the method of choice. The clinical phenotype of our patient was in agreement with that of patients with a terminal 10q deletion. For the purpose of genotype-phenotype analysis, there seems to be no need for a "ring syndrome" concept.

  18. Spatial Distortion in MRI-Guided Stereotactic Procedures: Evaluation in 1.5-, 3- and 7-Tesla MRI Scanners.

    Science.gov (United States)

    Neumann, Jan-Oliver; Giese, Henrik; Biller, Armin; Nagel, Armin M; Kiening, Karl

    2015-01-01

    Magnetic resonance imaging (MRI) is replacing computed tomography (CT) as the main imaging modality for stereotactic transformations. MRI is prone to spatial distortion artifacts, which can lead to inaccuracy in stereotactic procedures. Modern MRI systems provide distortion correction algorithms that may ameliorate this problem. This study investigates the different options of distortion correction using standard 1.5-, 3- and 7-tesla MRI scanners. A phantom was mounted on a stereotactic frame. One CT scan and three MRI scans were performed. At all three field strengths, two 3-dimensional sequences, volumetric interpolated breath-hold examination (VIBE) and magnetization-prepared rapid acquisition with gradient echo, were acquired, and automatic distortion correction was performed. Global stereotactic transformation of all 13 datasets was performed and two stereotactic planning workflows (MRI only vs. CT/MR image fusion) were subsequently analysed. Distortion correction on the 1.5- and 3-tesla scanners caused a considerable reduction in positional error. The effect was more pronounced when using the VIBE sequences. By using co-registration (CT/MR image fusion), even a lower positional error could be obtained. In ultra-high-field (7 T) MR imaging, distortion correction introduced even higher errors. However, the accuracy of non-corrected 7-tesla sequences was comparable to CT/MR image fusion 3-tesla imaging. MRI distortion correction algorithms can reduce positional errors by up to 60%. For stereotactic applications of utmost precision, we recommend a co-registration to an additional CT dataset. © 2015 S. Karger AG, Basel.

  19. LA CUESTIÓN AGRARIA COMO ENFOQUE Y COMO PROBLEMA

    Directory of Open Access Journals (Sweden)

    Carlos Salgado

    2000-01-01

    Full Text Available Este ensayo trata de llamar la atención sobre los problemas del agro hoy, colocando especial énfasis en la disrupción entre las razones tecnológicas -que se asumen como ideológicas-, económicas y políticas que han inspirado el desarrollo del agro, o mejor, sobre las cuales se han basado las políticas de crecimiento agropecuario.

  20. Ca isotopes in refractory inclusions

    International Nuclear Information System (INIS)

    Niederer, F.R.; Papanastassiou, D.A.

    1984-01-01

    We report measurements of the absolute isotope abundance of Ca in Ca-Al-rich inclusions from the Allende and Leoville meteorites. Improved high precision measurements are reported also for 46 Ca. We find that nonlinear isotope effects in Ca are extremely rare in these inclusions. The absence of nonlinear effects in Ca, except for the effects in FUN inclusions, is in sharp contrast to the endemic effects in Ti. One fine-grained inclusion shows an excess of 46 Ca of (7 +- 1) per mille, which is consistent with addition of only 46 Ca or of an exotic (*) component with 46 Ca* approx. 48 Ca*. FUN inclusion EK-1-4-1 shows a small 46 Ca excess of (3.3 +- 1.0) per mille; this confirms that the exotic Ca components in EK-1-4-1 were even more deficient in 46 Ca relative to 48 Ca than is the case for normal Ca. The Ca in the Ca-Al-rich inclusions shows mass dependent isotope fractionation effects which have a range from -3.8 to +6.7 per mille per mass unit difference. This range is a factor of 20 wider than the range previously established for bulk meteorites and for terrestrial and lunar samples. Ca and Mg isotope fractionation effects in the Ca-Al-rich inclusions are common and attributed to kinetic isotope effects. (author)

  1. Molecular studies of segmental aneusomy: FISHing for the atypical cry in del(5)(p15.3).

    Science.gov (United States)

    Hodge, J C; Lawson-Yuen, A; Stoler, J M; Ligon, A H

    2007-01-01

    We report a newborn male with multiple congenital anomalies including growth retardation, hypotonia, dysmorphic facies, widely-spaced nipples, micropenis, cryptorchidism, optic nerve hypoplasia, heart disease, and a striking, high-pitched cry. Chromosome analysis revealed de novo partial trisomy 11q due to a der(5)t(5;11)(p15.3;q22). Fluorescence in situ hybridization (FISH) showed loss of the 5p telomere signal on the der(5) chromosome, indicating the infant has partial monosomy 5p in addition to partial trisomy 11q. Among cases involving trisomy 11q, an unusual cry has only been documented in the presence of a der(5)t(5p;11q). This apparent dependence of the abnormal cry on monosomy 5p suggested the same genetic mechanism that occurs in Cri du chat syndrome (CDCS) may be responsible for the atypical cry in der(5)t(5p;11q) individuals. Neither a commercial CDCS probe (LSI D5S23, D5S721) nor a series of BAC clones encompassing distal regions implicated in the CDCS-associated cat-cry were deleted in our patient. These results suggest a second cry-modifying locus maps telomeric to BAC RP11-94J21 in band 5p15.33. This locus may not only cause the abnormal cry in individuals with a der(5)t(5p;11q) but could also contribute to the phenotypic variability and discordant mapping studies observed for CDCS. Copyright (c) 2007 S. Karger AG, Basel.

  2. Los ancianos como actores sociales

    Directory of Open Access Journals (Sweden)

    Mª PIA ARENYS

    1996-01-01

    Full Text Available En este artículo se recogen las discusiones de grupo que se realizaron durante cuatro meses en Barcelona como preparación del "II congreso de la gent gran" (II congreso de ancianos de esta ciudad, en noviembre de 1993. las discusiones se llevaron a cabo en las sedes de cada distrito, previa presentación de la ponencia por parte de un técnico. los componentes de los grupos son personas mayores sensibilizadas y comprometidas que forman parte del consejo de bienestar social del ayuntamiento de Barcelona. la metodología utilizada es cualitativa para el análisis del discurso, que se ha estructurado en los siguientes puntos: bajo el epígrafe "los ancianos como ciudadanos de derechos y obligaciones" se recogen los temas de valoración de la vejez, la familia, la jubilación, las implicaciones de los ancianos como ciudadanos de derechos y deberes y las funciones sociales de los ancianos.-- sobre estos temas, los mayores expresaron sus opiniones, que se vertieron, resumidamente, en la redacción final de la ponencia. aquí se recogen y se han analizado los materiales que ofrecen una versión de primera mano sobre lo que opinan los ancianos respecto al tema de "la valoración de la vejez".

  3. La proyección como proceso y como mecanismo

    OpenAIRE

    Brusset, Bernard

    2001-01-01

    La proyección es a la vez un mecanismo elemental testimonio de la fragilidad de la organización defensiva y un proceso cuyo rol es fundamental en el funcionamiento psíquico. En este doble aspecto, la proyección guarda especificidades diferentes en la neurosis y en la psicosis al punto que se las deba considerar como fundamentalmente diferentes? O bien las diferencias de contexto, del nivel del funcionamiento psíquico, de lugar, de función pueden explicar las diferencias clínicas justificando ...

  4. El dictado como tarea comunicativa

    Directory of Open Access Journals (Sweden)

    Daniel Cassany

    2004-01-01

    Full Text Available El artículo explora las utilidades didácticas del dictado (la práctica comunicativa de oralizar o leer en voz alta un escrito para el aprendizaje funcional de una lengua materna o extranjera, en los diversos niveles de enseñanza. Después de criticar el uso tradicional de este ejercicio lingüístico, presentamos once formas diferentes de desarrollar un dictado en clase, con sus particulares contenidos, objetivos y metodologías. También analizamos con detalle la técnica más tradicional del dictado magistral, en la que el docente dicta palabra por palabra un texto al alumnado, poniendo énfasis en la ortografía; ofrecemos algunas orientaciones para incrementar el componente comunicativo de esta propuesta. Las conclusiones finales proponen entender esta técnica como un recurso metodológico variado, rico y sugerente, adaptado a cada situación de aprendizaje —y no como una práctica obligatoria y fosilizada.

  5. Como Lo Hago Yo: Myelomeningocele

    Science.gov (United States)

    Lazareff, Jorge

    2014-01-01

    Fortificación con ádico fólico es efectiva, pero aún falta conciencia en los jóvenes. La legalidad del aborto aumenta la importancia de la consulta prenatal. Realizo la cirugía bajo microcoscopio por razones didácticas. Irrigación continua para reducir la temperatura del tejido. Trato a la plaqueta como tejido viable. No suturo la plaqueta. No cierro músculo. ATB por una semana después de cirugía. Hidrocefalia: Válvula en todos los casos de ventriculomegalia. Médula anclada: Desanclar una sola vez. Chiari II: Revisar la válvula. Incluir en el seguimiento rendimiento escolar, puede indicar obstrucción de la válvula o médula anclada. PMID:24791217

  6. El investigador como educador musical y como divulgador

    Directory of Open Access Journals (Sweden)

    Suárez-Pajares, Javier

    2000-05-01

    Full Text Available La presente ponencia trataba de plantear en la Mesa redonda "Investigación aplicada a la educación musical" una serie de problemas que surgen no tanto a quienes se dedican profesionalmente a la educación musical, sino a quienes, dedicados a la investigación y al estudio de temas relacionados con la historia de la música desde perspectivas diversas, tienen finalmente que transmitirlos a una audiencia determinada, ya sea otros colegas, alumnos de universidad, u otros públicos en los que se centra el concepto "divulgación" aludido en el título.Se incide particularmente en los problemas de la educación musical universitaria para no especialistas y en la divulgación científica aplicada a la música, un campo casi yermo sobre el que hay mucho que reflexionar: desde las nuevas posibilidades para la explicación de la música que ofrecen soportes nuevos como el CD-Rom, hasta las tradicionales formas de relación con un público melómano a través de notas a programas y críticas de conciertos.

  7. Parental imprinting of human chromosome region 11p15.3-pter involved in the Beckwith-Wiedemann syndrome and various human neoplasia

    NARCIS (Netherlands)

    Mannens, M.; Hoovers, J. M.; Redeker, E.; Verjaal, M.; Feinberg, A. P.; Little, P.; Boavida, M.; Coad, N.; Steenman, M.; Bliek, J.

    1994-01-01

    Cytogenetic and DNA analyses of patients with the Beckwith-Wiedemann syndrome (BWS) enabled us to refine the localization of the syndrome at 11p15.3-pter to two distinct regions. One chromosome region (BWSCR1) is near the insulin (INS) and insulin-like growth factor 2 (IGF2) genes. The other region

  8. Diseño, implementación y evaluación de una intervención multidimensional en riesgo de caídas, fragilidad y soledad como estrategia para la promoción del envejecimiento activo y saludable // Design, implementation and evaluation of a multidimensional intervention on risk of falling, frailty and loneliness as a strategy to promote active and healthy ageing

    OpenAIRE

    Alhambra Borrás, Tamara

    2017-01-01

    El envejecimiento poblacional es uno de los cambios demográficos más significativos acaecidos en las últimas décadas a nivel mundial. En consecuencia, las sociedades modernas se enfrentan al reto de hacer frente al envejecimiento desde una nueva perspectiva. El paradigma del envejecimiento activo y saludable se ha consolidado en las últimas décadas como la respuesta a este reto. Atendiendo a este paradigma, la vejez se entiende como una nueva etapa para seguir desarrollando nuestro potencial ...

  9. Solubility of calcium in CaO-CaCl2

    International Nuclear Information System (INIS)

    Perry, G.S.; Shaw, S.J.

    1991-06-01

    The Direct Oxide Reduction (DOR) process is well established as a process to produce plutonium metal from plutonium dioxide by reaction with calcium. Calcium chloride is added to dissolve the calcium oxide produced, allowing the metal to coalesce into a button. Since calcium metal melts at 840 0 C and DOR can take place successfully below this temperature, it is likely calcium dissolved in calcium chloride reacts with the plutonium dioxide. The solubility of calcium in calcium chloride is reasonably well established but the effect of the CaO formed during the DOR process on the solubility of calcium has not been previously determined. For this reason the solubility of calcium in CaCl 2 -CaO melts at 800 o C has been studied. The solubility decreases from 2.7 mol % in CaCl 2 to 0.4 mol % in 9 mol % CaO-CaCl 2 . (author)

  10. La lengua inglesa como neolengua

    Directory of Open Access Journals (Sweden)

    Fernando BELTRÁN LLAVADOR

    2009-11-01

    Full Text Available RESUMEN: El artículo examina algunos usos y abusos de la lengua inglesa en la actualidad en el contexto de la globalización. Se define la neolengua, se ofrecen similitudes de la misma en el lenguaje publicitario en España, se trazan sus orígenes y se apuntan algunos antecedentes en la historia de la literatura inglesa, al tiempo que se ilustran ejemplos de variantes contemporáneas de la misma bajo la denominación de «nukespeak», especialmente abundantes en el discurso de los conflictos bélicos. La lengua inglesa está indisociablemente unida a complejos factores de orden económico, tecnológico y cultural que afectan a su misma morfología. Por otra parte, la presencia ubicua de la lengua inglesa, como idioma global, opera sobre las estructuras de sentimiento, pensamiento y acción de los ciudadanos en todo el mundo. Para los profesionales de la enseñanza del idioma inglés, ello comporta la obligación de discernir y resistir sus efectos potencialmente perversos al tiempo que siguen promoviendo sus valiosos beneficios culturales.ABSTRACT: Contemporary uses and abuses of the English language are examined in the context of complex issues and globalization trends. The term «newspeak» is defined, similitudes of it are found today in the language of advertising in Spain, its origins are traced back and antecedents are located in the history of English literature, while the presence of new modalities of the Orwellian reductionist language, such as «nukespeak», is illustrated within the language of warfare. The English language is inextricably bound up with economical, technological and cultural factors which affect its very morphology just as much as the pervasive influence of English as a global language affects the structures of feeling, thought and action of citizens all over the world, which poses an obligation on the part of EFL teachers to discern and resist its ill effects while they promote its still highly valuable cultural

  11. Como responder ao momento presente?

    Directory of Open Access Journals (Sweden)

    Maria Filomena Molder

    2013-12-01

    Full Text Available http://dx.doi.org/10.5007/1984-784X.2013v13n19p13 Foi com esta pergunta — já um efeito de um primeiro encontro entre Irene Pimentel e eu própria — que decidimos desafiar colegas, estudantes e funci­onários da nossa Faculdade, FCSH (Faculdade de Ciências Sociais e Huma­nas, de outras Faculdades da Universidade Nova de Lisboa, de outras Uni­versidades e todos os interessados em con­siderar e discutir em comum aquilo que se passava em Portugal e que no anúncio da Jornada de 6 de De­zembro de 2012 se descrevia como um “processo de desmantela­mento social, económico e cultural sem precedentes — pese embora tantas compara­ções, baseadas na premissa da ‘eterna repetição’ — e cujas consequências não param de exceder as previsões dos responsáveis por esse desmantelamento”. Acedendo com todo o empenho e gratidão ao convite que me foi dirigido por Humberto Brito para fazer uma resenha da Jornada a publicar no primeiro número de Forma de Vida (saúdo a revista e o título, decidi-me, no entanto, a pôr de lado a resenha, que sob a forma de “Editorial” será em breve publi­cada no blogue Responder ao Momento Presente, entre­tanto criado, conjuntamente com os textos escritos pelos nossos convidados, com as parti­cipações de pessoas que corresponderam ao nosso apelo e ainda com contri­bui­ções que se alargaram para lá da Jornada; a que se juntará uma gravação em video, também disponível no Youtube.   Texto publicado originalmente em Forma de Vida, Lisboa, n.1, fev. 2013. Agrade­cemos à autora por permitir a republicação neste número do Boletim. [N.E.

  12. Accessing the nuclear symmetry energy in Ca+Ca collisions

    Directory of Open Access Journals (Sweden)

    Chbihi A.

    2012-07-01

    Full Text Available The status of the analysis of the INDRA-VAMOS experiement performed at GANIL, using the reactions 40,48Ca+40,48Ca reactions at 35AMeV, are presented. Isotopic distributions of fragments produced in multifragmentation events provide information on the importance of the surface term contribution in the symmetry energy by comparison to AMD predictions.

  13. La sabidur?a como competencia gerencial

    OpenAIRE

    Pinzon-Barrios, Ana-Maria; Cort?s Zapata, Gabriela

    2012-01-01

    Aunque el concepto de sabidur?a ha sido ampliamente estudiado por expertos de ?reas como la filosof?a, la religi?n y la psicolog?a, a?n enfrenta limitaciones en cuanto a su definici?n y evaluaci?n. Por esto, el presente trabajo tiene como objetivo, formular una definici?n del concepto de sabidur?a que permita realizar una propuesta de evaluaci?n del concepto como competencia en los gerentes. Para esto, se realiz? un an?lisis documental de tipo cualitativo. De esta manera, se analizaron divers...

  14. Los ritmos como terapia para la impulsividad

    Directory of Open Access Journals (Sweden)

    Mónica Triviño

    2012-10-01

    Full Text Available Investigaciones recientes muestran que el uso de patrones rítmicos facilita la respuesta óptima en el tiempo, por lo que el entrenamiento mediante ritmos podría proponerse como terapia novedosa ante problemas como la impulsividad. Esto podría beneficiar a pacientes con daño prefrontal o personas con trastorno por déficit de atención e hiperactividad (TDAH, que suelen mostrar conductas impulsivas, así como dificultad para estimar el paso del tiempo.

  15. La transparencia como objetivo del desarrollo sostenible

    OpenAIRE

    Juan José Gilli

    2017-01-01

    El presente trabajo tiene por propósito precisar el significado de la transparencia en la gestión pública como una exigencia de carácter ético relacionada con la información que los agentes deben dar en el ámbito sus funciones, reconociendo al ciudadano como el dueño de la información que producen y guardan. La transparencia tiene un especial valor como herramienta para combatir la corrupción y, de esa forma, contribuir a la meta de lograr instituciones inclusivas y efectivas para el desarrol...

  16. La universidad como organización

    Directory of Open Access Journals (Sweden)

    Luis Aurelio Ordoñez Burbano

    2001-07-01

    Full Text Available El presente artículo versa sobre la unviersidad como organización y tiene como objetivo hacer una reflexión sobre la misión de la universidad colombiana en el marco de diversos entornos. Como punto de partida, se propone una precisión sobre la misión de la universidad moderna y la investigación, a diferencia de la universidad colonial y decimonónica limitada a la divulgación de conocimientos preexistentes.

  17. Carolee Schneemann. El cine como autobiografía, la artista como actriz, el cuerpo como pincel

    Directory of Open Access Journals (Sweden)

    María Barbaño González-Moreno

    2017-10-01

    Full Text Available Este trabajo analiza la relación de cine y mujer a partir de la obra fílmica de Carolee Schneemann, principalmente de su obra autobiográfica Fuses (1964-1966. Desde ella, se plantea el papel de la artista como productora, directora y protagonista principal de todas sus obras. Reflexionamos así sobre el rol del creador-director como actor que derivaría en la consecución de una obra cinematográfica de tintes necesariamente autobiográficos. Asumiendo la visión vanguardista del cine como diario personal/Entendido el cine como diario personal, Schneemann va a explorar en su obra diferentes aspectos de la identidad y la sexualidad de la mujer en un cine artístico, alternativo y de tendencia política feminista. Entendido/Asumido su cine como elemento plástico, la artista explorará de forma paralela la experimentación matérica y física a través de los cuerpos filmados así como de la propia materialidad de la película, excluyendo toda posibilidad narrativa, dramática e ilusoria de proyección del espectador en el espacio cinematográfico y el espacio privado del creador.

  18. The site of net absorption of Ca from the intestinal tract of growing pigs and effect of phytic acid, Ca level and Ca source on Ca digestibility.

    Science.gov (United States)

    González-Vega, J Caroline; Walk, Carrie L; Liu, Yanhong; Stein, Hans H

    2014-01-01

    An experiment was conducted to test the hypothesis that the standardised digestibility of Ca in calcium carbonate and Lithothamnium calcareum Ca is not different regardless of the level of dietary Ca, and that phytic acid affects the digestibility of Ca in these two ingredients to the same degree. The objectives were to determine where in the intestinal tract Ca absorption takes place and if there are measurable quantities of basal endogenous Ca fluxes in the stomach, small intestine or large intestine. Diets contained calcium carbonate or L. calcareum Ca as the sole source of Ca, 0% or 1% phytic acid and 0.4% or 0.8% Ca. A Ca-free diet was also formulated and used to measure endogenous fluxes and losses of Ca. Nine growing pigs (initial body weight 23.8 ± 1.3 kg) were cannulated in the duodenum and in the distal ileum, and faecal, ileal and duodenal samples were collected. Duodenal endogenous fluxes of Ca were greater (p calcareum Ca diets, but that was not the case if calcium carbonate was the source of Ca (interaction, p calcareum Ca was greater (p calcareum Ca. In conclusion, under the conditions of this experiment, standardised digestibility of Ca is not affected by the level of phytic acid, but may be affected by dietary Ca level depending on the Ca source. Calcium from calcium carbonate is mostly absorbed before the duodenum, but Ca from L. calcareum Ca is mostly absorbed in the jejunum and ileum.

  19. El videojuego como material educativo: La Odisea

    Directory of Open Access Journals (Sweden)

    Belén Mainer Blanco

    2012-04-01

    Full Text Available La investigación se basa en la función educativa que pueden cumplir los videojuegos, un campo que consideramos inexplorado por tres motivos principalmente: su reciente incorporación, su impopularidad educativa (el rechazo el videojuego como herramienta de aprendizaje y considerado, por el contrario, como una distracción, y la incompleta incorporación de las nuevas tecnologías de información y comunicación (TIC en el ámbito familiar y educativo. En una segunda parte, se ha realizado una aplicación práctica tomando como referencia la gran obra universal “La Odisea”, cuya intención es mostrar la utilidad del videojuego como complemento educativo.

  20. El Derecho como argumentación

    Directory of Open Access Journals (Sweden)

    Atienza, Manuel

    1999-11-01

    Full Text Available Not available

    Frente a las concepciones del Derecho como norma, como hecho o como valor (que caracterizan, respectivamente, al norrnativismo, al realismo jurídico y al iusnaturalismo, se propone aquí un cuarto enfoque que consiste en ver el Derecho como argumentación (y que cohra especial relevancia en las sociedades democráticas. Sin embargo, no hay una única forma de entender la argumentación jurídica. Aunque conectadas entre sí, en el trabajo se distinguen tres concepciones: la formal, la material y la pragmática o dialéctica; muchas cuestiones que se plantean en el ámbito de la teoría de la argumentación jurídica pueden resolverse -o aclararse- teniendo en cuenta esa triple perspectiva.

  1. Rates for some reactions involving 42Ca and 44Ca

    International Nuclear Information System (INIS)

    Cheng, C.W.; King, J.D.

    1980-01-01

    Ground-state reaction rates have been deduced from recent cross section measurements for the 42 CA(α, n) 45 Ti, 42 Ca(p, γ) 43 Sc, and 44 Ca(p, n) 44 Sc reactions. Comparison of these rates with those calculated from a statistical model of nuclear reactions. (Woosley et al) shows good agreement for the first two, but the 44 Ca(p, n) rate is more than a factor of 2 less than the theoretical prediction. Stellar reaction rates have been derived from the ground-state rates by multiplying the ground-state rates by the ratio of stellar to ground-state rates given by the statistical model. Both ground-state and stellar rates have been represented by analytic functions of the temperature. The role of these reactions in the approach to quasi-equilibrium during explosive silicon burning is discussed

  2. La sangre como espectáculo.

    Directory of Open Access Journals (Sweden)

    Rubén Darío Buitrón

    2015-01-01

    Full Text Available El autor asevera que cuando la información es concebida y tratada como una mercancía y no como un bien social, la avidez por el lucro la degenera en productos abyectos donde la sangre es espectáculo que sirve para exacerbar el morbo social, incrementar las ventas y los ingresos publicitarios. Señala que lamentablemente en el Ecuador este tipo de periodismo es una plaga muy bien vendida.

  3. Efeitos de relações CaSO4/CaCO3 na mobilidade de nutrientes no solo e no crescimento do algodoeiro

    Directory of Open Access Journals (Sweden)

    A. A. Silva

    1998-09-01

    Full Text Available O experimento, realizado em casa de vegetação no Departamento de Ciência do Solo da Universidade Federal de Lavras, teve por objetivo estudar o efeito de diferentes relações de CaSO4/CaCO3, que simulam o uso de gesso e calcário, na movimentação de nutrientes no solo e no crescimento do algodoeiro, cultivar IAC-20. As proporções de CaSO4/CaCO3 utilizadas foram: 0/100, 25/75, 50/50, 75/25 e 100/0, com base em peso equivalente, além de um tratamento-testemunha, sem aplicação de CaSO4 e CaCO3. Observou-se acentuada movimentação de cálcio e de sulfato em profundidade, como íons acompanhantes, com o aumento da relação CaSO4/CaCO3. Para o N-NO3- e Mg2+, ao contrário do N-NH4+ e K+, observou-se um acúmulo em profundidade, com a elevação da relação CaSO4/CaCO3. Neste estudo, o gesso teve pouco ou nenhum efeito sobre a acidez e Al trocável presentes nas camadas subsuperficiais. A produção de matéria seca do algodoeiro foi reduzida com o aumento da relação CaSO4/CaCO3, porém, quando comparada à do tratamento-testemunha, a aplicação de gesso aumentou-a significativamente, atestando o potencial de uso do gesso agrícola.

  4. Las leyendas regionales como intangibles territoriales

    Directory of Open Access Journals (Sweden)

    Eloy Martos Núñez

    2015-01-01

    Full Text Available El artículo examina el concepto de leyenda como intangible territorial en diversas escalas, desde la local a la regional o nacional, y su relación con la construcción de mitos étnicos y la emergencia de tradiciones translocales. Para ello, se revisan la metodología de los estudios corográficos y las nociones de ecotipo y de paisaje cultural, así como la etnografía de los territorios simbólicos a la luz de conceptos como el clásico «témenos» y modernos como el «mytho-moteur» (Abadal, 1958. Se aplican estudios de casos que evidencian cómo es el Imaginario, en interacción con factores geohistóricos del lugar, el que a menudo acota y perimetrea un territorio a través de cauces como la fabulación legendaria y los ritos paralitúgicos, como procesiones o peregrinaciones. La conclusión es que las leyendas y los arquetipos de origen étnico y genealógico reescriben tradiciones que crean identidades y se pueden proyectar en ámbitos diferentes de la vida política o recreativa, con perfiles igualmente diferentes.

  5. Propiedades nutricionales y antioxidantes de la cañihua (Chenopodium pallidicaule Aellen)

    OpenAIRE

    Bartolo Estrella, Dolly Elisa

    2013-01-01

    El objetivo de esta revisión fue detallar las propiedades nutricionales y antioxidantes de la cañihua (Chenopodium pallidicaule Aellen). La cañihua es uno de los granos andinos menos estudiados y más nutritivos, debido a su contenido y calidad proteica. Esta planta a causa de su crecimiento en condiciones climáticas extremas, como en el altiplano (4000 m.s.n.m.), probablemente ha desarrollado una protección natural contra la oxidación. Los reportes indican que la cañihua tiene una calidad pro...

  6. Transmutation of 129I and 237Np using spallation neutrons produced by 1.5, 3.7 and 7.4 GeV protons

    International Nuclear Information System (INIS)

    Ochs, M.; Schmidt, Th.; Wan, J.-S.

    1999-01-01

    Small samples of approximately 1 g of 129 I and 237 Np, two long-lived radioactive waste nuclides, were exposed to spallation neutron fluences from relatively small metal targets of lead or uranium, surrounded with a paraffin moderator 6 cm thick irradiated with 1.5, 3.7 and 7.4 GeV protons. The (n, γ) transmutation rates have been determined for the two radioactive waste nuclides. Conventional radiochemical La and U sensors and a variety of solid-state nuclear track detectors were irradiated simultaneously with secondary neutrons. The observed secondary neutron fluences appear to be systematically larger, as compared to the calculations with the well-known cascade codes (LAHET from Los Alamos and DCM-CEM from Dubna)

  7. Transmutation of 129I and 237Np using spallation neutrons produced by 1.5, 3.7 and 7.4 GeV protons

    International Nuclear Information System (INIS)

    Wan, J.-S.; Schmidt, T.Th.; Langrock, E.-J.; Vater, P.; Brandt, R.; Adam, J.; Bradnova, V.; Bamblevski, V.P.; Gelovani, L.; Gridnev, T.D.; Kalinnikov, V.G.; Krivopustov, M.I.; Kulakov, B.A.; Sosnin, A.N.; Perelygin, V.P.; Pronskikh, V.S.; Stegailov, V.I.; Tsoupko-Sitnikov, V.M.; Modolo, G.; Odoj, R.; Phlippen, P.-W.; Zamani-Valassiadou, M.; Adloff, J.C.; Debeauvais, M.; Hashemi-Nezhad, S.R.; Guo, S.-L.; Li, L.; Wang, Y.-L.; Dwivedi, K.K.; Zhuk, I.V.; Boulyga, S.F.; Lomonossova, E.M.; Kievitskaja, A.F.; Rakhno, I.L.; Chigrinov, S.E.; Wilson, W.B.

    2001-01-01

    Small samples of 129 I and 237 Np, two long-lived radwaste nuclides, were exposed to spallation neutron fluences from relatively small metal targets of lead and uranium, that were surrounded with a 6 cm thick paraffin moderator, and irradiated with 1.5, 3.7 and 7.4 GeV protons. The (n,γ) transmutation rates were determined for these nuclides. Conventional radiochemical La- and U-sensors and a variety of solid-state nuclear track detectors were irradiated simultaneously with secondary neutrons. Compared with results from calculations with well-known cascade codes (LAHET from Los Alamos and DCM/CEM from Dubna), the observed secondary neutron fluences are larger

  8. Transmutation of {sup 129}I and {sup 237}Np using spallation neutrons produced by 1.5, 3.7 and 7.4 GeV protons

    Energy Technology Data Exchange (ETDEWEB)

    Wan, J.-S.; Schmidt, T.Th.; Langrock, E.-J.; Vater, P.; Brandt, R. E-mail: brandtr@mailer.uni-marburg.de; Adam, J.; Bradnova, V.; Bamblevski, V.P.; Gelovani, L.; Gridnev, T.D.; Kalinnikov, V.G.; Krivopustov, M.I.; Kulakov, B.A.; Sosnin, A.N.; Perelygin, V.P.; Pronskikh, V.S.; Stegailov, V.I.; Tsoupko-Sitnikov, V.M.; Modolo, G.; Odoj, R.; Phlippen, P.-W.; Zamani-Valassiadou, M.; Adloff, J.C.; Debeauvais, M.; Hashemi-Nezhad, S.R.; Guo, S.-L.; Li, L.; Wang, Y.-L.; Dwivedi, K.K.; Zhuk, I.V.; Boulyga, S.F.; Lomonossova, E.M.; Kievitskaja, A.F.; Rakhno, I.L.; Chigrinov, S.E.; Wilson, W.B

    2001-05-11

    Small samples of {sup 129}I and {sup 237}Np, two long-lived radwaste nuclides, were exposed to spallation neutron fluences from relatively small metal targets of lead and uranium, that were surrounded with a 6 cm thick paraffin moderator, and irradiated with 1.5, 3.7 and 7.4 GeV protons. The (n,{gamma}) transmutation rates were determined for these nuclides. Conventional radiochemical La- and U-sensors and a variety of solid-state nuclear track detectors were irradiated simultaneously with secondary neutrons. Compared with results from calculations with well-known cascade codes (LAHET from Los Alamos and DCM/CEM from Dubna), the observed secondary neutron fluences are larger.

  9. Transmutation of 129I and 237Np using spallation neutrons produced by 1.5, 3.7 and 7.4 GeV protons

    Science.gov (United States)

    Wan, J.-S.; Schmidt, Th.; Langrock, E.-J.; Vater, P.; Brandt, R.; Adam, J.; Bradnova, V.; Bamblevski, V. P.; Gelovani, L.; Gridnev, T. D.; Kalinnikov, V. G.; Krivopustov, M. I.; Kulakov, B. A.; Sosnin, A. N.; Perelygin, V. P.; Pronskikh, V. S.; Stegailov, V. I.; Tsoupko-Sitnikov, V. M.; Modolo, G.; Odoj, R.; Phlippen, P.-W.; Zamani-Valassiadou, M.; Adloff, J. C.; Debeauvais, M.; Hashemi-Nezhad, S. R.; Guo, S.-L.; Li, L.; Wang, Y.-L.; Dwivedi, K. K.; Zhuk, I. V.; Boulyga, S. F.; Lomonossova, E. M.; Kievitskaja, A. F.; Rakhno, I. L.; Chigrinov, S. E.; Wilson, W. B.

    2001-05-01

    Small samples of 129I and 237Np, two long-lived radwaste nuclides, were exposed to spallation neutron fluences from relatively small metal targets of lead and uranium, that were surrounded with a 6 cm thick paraffin moderator, and irradiated with 1.5, 3.7 and 7.4 GeV protons. The (n,γ) transmutation rates were determined for these nuclides. Conventional radiochemical La- and U-sensors and a variety of solid-state nuclear track detectors were irradiated simultaneously with secondary neutrons. Compared with results from calculations with well-known cascade codes (LAHET from Los Alamos and DCM/CEM from Dubna), the observed secondary neutron fluences are larger.

  10. Tumor markers cancer antigen 15.3, carcinoembryonic antigen, and tissue polypeptide antigen for monitoring metastatic breast cancer during first-line chemotherapy and follow-up

    DEFF Research Database (Denmark)

    Sölétormos, G; Nielsen, D; Schiøler, V

    1996-01-01

    progressive disease, the median positive lead time was 35 days during therapy and 76 days during follow-up. Tumor marker assessment may document that a therapy is effective and ought to be continued in spite of adverse toxic effects, and that a treatment is ineffective and should be stopped to prevent......We investigated whether model systems integrating stochastic variation into criteria for marker assessment could be used for monitoring metastatic breast cancer. A total of 3989 serum samples was obtained from 204 patients receiving first-line chemotherapy and from 112 of these patients during...... follow-up. Each sample was analyzed for cancer antigen 15.3, carcinoembryonic antigen, and tissue polypeptide antigen. The efficiency for identifying progression and nonprogression was 94% during therapy and 85% during follow-up, with no false-positive marker results for progressive disease. At clinical...

  11. 15-3-2 : ナノファイバーを用いた高性能駆動材料の創出

    OpenAIRE

    平井, 利博; 高田, 素志; 木村, 睦

    2005-01-01

    We found remarkable improvement of motility of dielectric polymeric materials as artificial muscles, when carbon nanomaterial was employed as soft electrodes (reported by Islam, PD research stuff in our group). However the electrode does not have enough durability for practical use. In this research, we developed a highly elastic, endurable up to ca.800% elongation, electrode material, using ABA-type block copolymer. We also developed novel electrode deposition method, which we named “dipping...

  12. La realidad como materia novelable: Alejo Carpentier

    Directory of Open Access Journals (Sweden)

    Raquel Arias Careaga

    2007-12-01

    Full Text Available Desde que en 1897 Benito Pérez Galdós defendiera como materia prima legítima de la literatura «la vida misma, de donde el artista saca las ficciones que nos instruyen y embelesan» (Pérez Galdós, 1990: 159, el realismo como instrumento de indagación y análisis de la sociedad no ha dejado de crecer y expandirse. Realismo crítico, como este de Galdós, que implica una ampliación del concepto chato de «realidad», incluyendo en ella «recuerdos, sueños, imaginación, locura, símbolos» para contribuir a la formación de un «realismo total» (Rodríguez Puértolas, 2000, II: 93, al que se une también la asimilación de enseñanzas esenciales como la que representa la narrativa de Cervantes: La novelística de Galdós hunde sus raíces en el mejor Cervantes, como puede verse en su peculiar sentido del humor y de la ironía, en la concepción perspectivista de la realidad y en tantas otras cosas, algunas de ellas en verdad fundamentales. Así el concepto de la Naturaleza y sus relaciones dialécticas con el ser humano; así el Amor como elemento vital y animador del orden cósmico, muy alejado del idealismo vulgar romántico (Ibid., 93.

  13. A Imagem como Ruína

    Directory of Open Access Journals (Sweden)

    Míriam Volpe

    2001-12-01

    Full Text Available O dialogismo ente o filme Citizen Kane, de Orson Welles, e o poema “Kubla Khan”, de S.T. Coleridgé, é analisado, sendo evidenciados não só o tema em comum – o mito do Paraíso perdido – como também a similariedade na organização do disurso na justaposição das images, como fragmentos da memória a serem preservados.

  14. Los rincones como contextos significativos de aprendizaje

    OpenAIRE

    Sánchez Molero, María Luisa

    2016-01-01

    En el presente trabajo se pretende hacer un estudio sobre los rincones de trabajo en el aula de Educación Infantil, describiéndolos como modelo de organización del espacio y como estrategia metodológica que aboga por un aprendizaje socioconstructivista. El estudio se completa con la descripción y el análisis de los rincones de un aula específica de un centro escolar, incorporando diversas propuestas de mejora fundamentadas en el previo estudio teórico

  15. PARP-1 como regulador del ciclo celular

    OpenAIRE

    Iglesias Vázquez, Pablo

    2015-01-01

    En el presente estudio hemos querido investigar las implicaciones biológicas de la interacción PARP-1/E2F-1 en escenarios en los que el factor de transcripción E2F-1 resulta de gran importancia como son el desarrollo embrionario y la oncogénesis. En este respecto, hemos demostrado que tanto PJ34, inhibidor de la actividad enzimática de PARP, como gosipol, inhibidor de las interacciones proteína-proteína, son capaces de reducir la actividad transcripcional de E2F-1 y la proli...

  16. Dibujo infantil como medio de diagnostico

    OpenAIRE

    González Hernando, Elisa

    2015-01-01

    Con este documento se pretende demostrar la importancia que tiene el dibujo infantil en el correcto desarrollo integral de las personas. Se estudia la importancia del dibujo y su valor a la hora de utilizarlo como método de diagnóstico ante determinados aspectos que pueden determinar la vida de una persona. En definitiva lo que se desarrolla en este trabajo de Fin de Grado es el papel que juega el dibujo como herramienta para el seguimiento del desarrollo de los individuos centrándonos ...

  17. La fatiga como estado motivacional subjetivo

    OpenAIRE

    D. Cárdenas; J. Conde-González; J.C. Perales

    2017-01-01

    Actualmente no existe consenso sobre los factores que determinan la aparición de la fatiga. Hay factores que se derivan exclusivamente del esfuerzo físico, otros que dependen del esfuerzo mental que este lleva aparejado, y otros de los resultados de la tarea que se está realizando. Como consecuencia, se han desarrollado diferentes modelos explicativos que pretenden aunar las diferentes razones de su aparición. No obstante, la tendencia actual es entender la fatiga como un estado motivacion...

  18. Quitina y carboximetilquitosana como agentes desintegrantes

    OpenAIRE

    Sol A Fernández Monagas; María D Rodríguez Albadalejo; Ofelia Bilbao Revoredo; Olga M Nieto Acosta

    1998-01-01

    Se realizó un estudio comparativo de la quitina y la carboximetilquitosana como agentes desintegrantes, y se evaluó la influencia ejercida por el método empleado en la elaboración de las tabletas sobre la actividad desintegrante de ambos polímeros. La quitina presentó buenas características como agente desintegrante independientemente del método utilizado en la elaboración de las tabletas, mientras que la actividad desintegrante de la carboximetilquitosana fue afectada por el proceso de granu...

  19. Heidegger E A Técnica Moderna Como Perigo E Como Salvação

    Directory of Open Access Journals (Sweden)

    Robson Costa Cordeiro

    2014-04-01

    Full Text Available O mundo contemporâneo é marcado por uma compreensão de técnica que se ergue como tal a partir de um sentido próprio e autônomo. Este sentido pode ser caracterizado como um logos que se constitui a partir de sua própria natureza e se manifesta como tecnologia no decorrer da história. Compreender esse sentido e assumi-lo como condição de nossa existência no mundo é comprender a técnica como nossa herança e nosso envio. Nesse sentido, compreender a essência da técnica é fundamental para o mundo contemporâneo, assumindo que, nesse processo, consiste o perigo e a salvação da espécie.

  20. CaWingz user's guide

    International Nuclear Information System (INIS)

    Cha, Ben-chin.

    1994-01-01

    This document assumes that you have read and understood the Wingz user's manuals. CaWingz is an external Wingz program which, when combined with a set of script files, provides easy-to-use EPICS channel access interface functions for Wingz users. The external function run allows Wingz user to invoke any Unix processor within caWingz. Few additional functions for accessing static database field and monitoring of value change event is available for EPICS users after release 3.11. The functions, script files, and usage are briefly described in this document. The script files supplied here serve as examples only. Users are responsible for generating their own spreadsheet and script files. CaWingz communicates with IOC through channel access function calls

  1. APROVECHAMIENTO DE RESIDUOS AGROINDUSTRIALES COMO BIOCOMBUSTIBLE Y BIOREFINERÍA

    Directory of Open Access Journals (Sweden)

    DEYANIRA MUÑOZ-MUÑOZ

    Full Text Available El aprovechamiento de residuos generados en procesos agroindustriales, es de interés en el ámbito mundial. En la actualidad se investiga en biomasa lignocelulósica para obtener energía, combustibles, biomateriales y productos químicos, mediante tecnologías limpias y sistemas cerrados que permitan conservar el medio ambiente. En esta investigación, a partir de características de residuos agroindustriales típicos del Departamento del Cauca, bagacillo de caña, polvillo de fique, afrecho de yuca y sus mezclas, se evalúo el aprovechamiento como biorefinería. Se determinaron las propiedades térmicas, físicas químicas y morfológicas en siete muestras de residuos, se realizaron ensayos exploratorios de pre-tratamientos y posibles usos. Se concluye que la muestra M6 con el 9,93% de humedad, 4,12% de ceniza, 43,97% de carbono, 5,86% de hidrogeno, 0,43% nitrógeno, poder calorífico inferior de 15MJ/kg y con 22,25% de celulosa, 9,30% de hemicelulosa y 4,56% de lignina, presenta características apropiadas para ser utilizada en hornos y calderas de menor potencia para el sector rural por la cantidad de ceniza, la cual mantiene estable el poder calorífico inferior y reduce la emisión de material particulado. Por las características térmicas, físicas, químicas y morfológicas, todas las muestras de M1 a M7, pueden ser hidrolizadas, densificadas y aprovechadas como biocombustible y/o biorefinería.

  2. La biblioteca como editora de contenidos

    Directory of Open Access Journals (Sweden)

    Alonso-Arévalo, Julio

    2015-12-01

    Full Text Available Una de las características más innovadoras de la biblioteca del siglo 21 tiene que ver con la toma de una postura activa frente a la gestión y generación de contenidos. Con la llegada de la Web 2.0 las bibliotecas no sólo siguen salvaguardando y difundiendo información como han venido realizando a lo largo de su historia, también cada vez con más frecuencia crean nueva información con el objetivo de prestar los mejores servicios a sus ciudadanos, a través de recursos y servicios tales como la elaboración guías de investigación, boletines de alerta y novedades, recursos web, información a través de sus blogs, y como administradores de contenidos a través de repositorios y revistas de acceso abierto. Un paso más allá en esta dinámica tienen que ver con la biblioteca como editora y distribuidora de libros, especialmente en el ámbito local, siendo la impulsora, formadora, dinamizador y difusoras de las obras de los autores de su comunidad.

  3. A rota como memória

    Directory of Open Access Journals (Sweden)

    Patrick Fraysse

    Full Text Available No contexto de estudo do patrimônio por um ponto de vista comunicacional, este artigo permitiu-nos visualisar um objeto de comunicação por excelência « a estrada » como portador de informação a decifrar e a interpretar um documento, mas também como um repositário da memória coletiva, quer dizer um monumento. Paralelamente, a patrimonialização dos monumentos, dos conjuntos arquiteturais e sobretudo dos itinerários que os religam, dito de outra maneira, da estrada, assim como a sua documentarização (relatos de viagens, guias, bancos de dados participam de uma nova institucionalização da memória integrante também das estradas míticas como o caminho de São Tiago na França ou a famosa estrada 66 nos Estados-Unidos.

  4. La medicina tradicional como medicina ecocultural

    OpenAIRE

    Aparicio Mena, Alfonso Julio

    2005-01-01

    Los sistemas terap??uticos tradicionales responden a las culturas de los pueblos en los que surgen. En ellos, se concibe la naturaleza ??ntimamente ligada a la tradici??n. Salud es, para los miembros de las culturas tradicionales, bienestar como equilibrio entre el ser humano, la naturaleza, las creencias y la sociedad.

  5. Los patrones de asentamiento como recurso patrimonial

    Directory of Open Access Journals (Sweden)

    Antonio Lista Martín

    2012-12-01

    Full Text Available Los patrones de asentamiento son las pautas con las que distribuyen los diferentes elementos construidos, como casas, caminos, campos, espacios públicos o fábricas, y son una expresión cultural de la sociedad que los construye. Tanto el tipo de elementos, su número como su distribución, dependen del nivel tecnológico, de la estructura social y de su bagaje cultural. Se puede decir, por tanto, que en los patrones estaría reflejado el conocimiento que la sociedad tenia del medio, así como sus anhelos, prioridades e, incluso, sus malas prácticas. La presente comunicación propone que estos patrones puedan servir de base para el planeamiento territorial actual, no sólo preservando aquello que realmente tenga valor, sino incluso recreándolos o reproduciéndolos a otras escalas siempre que puedan aportar un valor añadido al territorio. El escrito plantea una pregunta: ¿Qué se debe mantener de los patrones tradicionales y qué se puede, o incluso se debe, cambiar?, y para responderla en la primera parte se analizan someramente algunos asentamientos-tipo y en la segunda se indican pautas de actuación que han aparecido como propuestas en planes de ordenación territorial en los últimos años.

  6. EL PERIODISMO CIVICO COMO COMUNICACION POLITICA

    Directory of Open Access Journals (Sweden)

    Ana María Miralles C.

    1998-01-01

    Full Text Available La autora retoma el ejercicio del periodismo cívico como el espacio en el cual la formación de la opinión pública adquiere características de un proyecto político dinámico en el que el ciudadano es el ente fundamental.

  7. Weak transitions in 44Ca

    International Nuclear Information System (INIS)

    Tauhata, L.; Marques, A.

    1972-01-01

    Energy levels and gamma radiation transitions of Ca 44 are experimentally determined, mainly the weak transition at 564 KeV and 728 KeV. The decay scheme and the method used (coincidence with Ge-Li detector) are also presented [pt

  8. Control of ciliary motility by Ca2+: Integration of Ca2+-dependent functions and targets for Ca2+ action

    International Nuclear Information System (INIS)

    Evans, T.C.

    1988-01-01

    To identify functions that regulate Ca 2+ -induced ciliary reversal in Paramecium, mutants defective in terminating depolarization-induced backward swimming were selected. Six independent recessive mutations (k-shy) comprising two complementation groups, k-shyA and k-shyB, were identified. All mutants exhibited prolonged backward swimming in depolarizing solutions. Voltage clamp studies revealed that mutant Ca 2+ current amplitudes were reduced, but could be restored to wild type levels by EGTA injection. The recovery of the mutant Ca 2+ current from Ca 2+ -dependent inactivation, and the decay of the Ca 2+ -dependent K + and Ca 2+ -dependent Na + currents after depolarization were slow in k-shy compared to wild type. To identify protein targets of Ca 2+ action, ciliary proteins that interact with calmodulin (CaM) were characterized. With a 125 I-CaM blot assay, several CaM-binding proteins were identified including axonemal, soluble, and membrane-bound polypeptides. Competitive displacement studies with unlabeled Paramecium CaM, bovine CaM, and troponinC suggested that both protein types bind CaM with high affinity and specificity. To examine the presence of CaM-binding sites in intact axonemes, a filtration binding assay was developed

  9. Ca isotopic fractionation patterns in forest ecosystems

    Science.gov (United States)

    Kurtz, A. C.; Takagi, K.

    2012-12-01

    Calcium stable isotope ratios are an emerging tracer of the biogeochemical cycle of Ca that are just beginning to see significant application to forest ecosystems. The primary source of isotopic fractionation in these systems is discrimination against light Ca during uptake by plant roots. Cycling of vegetation-fractionated Ca establishes isotopically distinct Ca pools within a forest ecosystem. In some systems, the shallow soil exchangeable Ca pool is isotopically heavy relative to Ca inputs. This has been explained by preferential removal of light Ca from the soil. In other systems, the soil exchange pool is isotopically light relative to inputs, which is explained by recycling of plant-fractionated light Ca back into soil. Thus vegetation uptake of light Ca has been called on to account for both isotopically heavy and light Ca in the shallow soil exchange pools. We interpret patterns in ecosystem δ44Ca with the aid of a simple box model of the forest Ca cycle. We suggest that the δ44Ca of exchangeable Ca in the shallow soil pool primarily reflects the relative magnitude of three key fluxes in a forest Ca cycle, 1) the flux of external Ca into the system via weathering or atmospheric deposition, 2) the uptake flux of Ca from soils into the vegetation pool, and 3) the return flux of Ca to shallow soils via remineralization of leaf litter. Two observations that emerge from our model may aid in the application of Ca isotopes to provide insight into the forest Ca cycle. First, regardless of the magnitude of both vegetation Ca uptake and isotopic fractionation, the δ44Ca of the soil exchange pool will equal the input δ44Ca unless the plant uptake and remineralization fluxes are out of balance. A second observation is that the degree to which the shallow soil exchange pool δ44Ca can differ from the input ratio is controlled by the relative rates of biological uptake and external Ca input. Significant differences between soil exchange and input δ44Ca are seen only

  10. MEMORIA VISUAL COMO PARTE DEL PROCESO LECTOR

    OpenAIRE

    Gamero-Muñiz, Antonia

    2013-01-01

    Este trabajo tiene como objetivo indagar la relación entre los movimientos sacádicos, velocidad y comprensión lectora y la memoria visual en alumnos de 2ºESO, con el propósito de contribuir a la labor docente en los apoyos del aprendizaje de una correcta lectura y tomando como fundamentación teórica la importancia de la memoria visual en el proceso lector. Se ha seleccionado una muestra de 24 niños y 21 niñas con edades comprendidas entre 13 y 15 años. Se evaluaron los movimientos sacádico...

  11. La fenomenología como atavismo

    Directory of Open Access Journals (Sweden)

    Galán, Iván

    2009-04-01

    Full Text Available This paper deals with phenomenology as a result of phenomenological freedom in its possibility of understanding a phenomenon as wild phenomenon. From this perspective, we are enabled to transcend established symbolic systems and to pose the question on the existence of a sense which is immature, not-saturated and imperfect without exception.El artículo pretende mostrar la vigencia de la fenomenología como expresión de la libertad fenomenológica, como posibilidad siempre abierta de acceder al fenómeno en cuanto fenómeno puro, registro arquitectónico en el que, saltando por sobre los sistemas simbólicos instituidos, nos es permitido plantear en toda su radicalidad la pregunta por la existencia de un sentido siempre prematuro, no saturado y jamás clausurable.

  12. O historiador como intelectual mediador da cultura

    Directory of Open Access Journals (Sweden)

    Alex Fernandes Borges

    2017-07-01

    Full Text Available O presente artigo visa analisar teoricamente a possibilidade de se qualificar o historiador, tomando por base uma tipologia ideal extraída da teoria da história de Jörn Rüsen, como um intelectual mediador, notadamente com base no conceito proposto a partir dos estudos de mediação cultural desenvolvido por Jesús Martín-Barbero e recentemente sistematizado no país por Ângela de Castro Gomes e Patrícia Hansen. Diante disso, articulou-se as hipóteses em três eixos: caracterização do intelectual mediador da cultura como uma categoria de análise compreensiva; instituição de um tipo ideal de historiador nos moldes weberianos e; a subsunção deste àquela.

  13. La Realidad Aumentada como complemento motivacional

    Directory of Open Access Journals (Sweden)

    Gazcón, Nicolás Fernando

    2016-06-01

    Full Text Available El acelerado avance de la tecnología permite que las tecnologías emergentes sean accesibles por todos los usuarios. Ejemplos de estas tecnologías son la Realidad Aumentada y la Reconstrucción 3D, que gracias a dispositivos como tabletas o teléfonos inteligentes, pueden utilizarse de manera ubicua. Éstas tienen un enorme potencial en el campo de la educación, ya sea como recurso para entender conceptos complejos, como para motivar el aprendizaje de nuevos contenidos. El desafío de estas tecnologías es integrarlas para que sean accesibles y fáciles de utilizar por los docentes y los alumnos. En este trabajo presentamos una metodología para motivar el aprendizaje tanto en tareas de campo, mediante el uso de la Reconstrucción 3D, como en el ámbito escolar mediante libros aumentados. Por medio de un caso de estudio introducimos la Reconstrucción 3D de elementos fósiles de un sitio paleontológico bonaerense, para luego incorporar estos contenidos generados en un libro aumentado. A partir de la digitalización de huellas y fósiles de sitios paleontológicos, se obtuvieron modelos 3D que se integraron en un ambiente de aprendizaje inmersivo en el aula mediante los libros aumentados. Presentamos las opiniones de docentes de distintas disciplinas, que resaltan las posibilidades de esta metodología para su inclusión en el ámbito educacional regional.

  14. EL CONFLICTO COMO CONSTRUCTOR DE CIUDAD

    Directory of Open Access Journals (Sweden)

    Twiggy Ortegón

    2012-04-01

    Full Text Available El planteamiento central de este articulo, es el de sugerir una análisis en torno a algunas de las condiciones o mecanismo necesarios para que el conflicto opere como un potenciador de la diferencia y creador de alternativas para la convivencia Se realiza una distinción del concepto, un análisis de contenidos interaccionales en dinámicas de conflicto y su relación con el contexto urbano de Bogotá, enfocándose en ámbitos escolares. En ciudades como Bogotá, las discusiones y acciones que diferentes estamentos han emprendido frente a la manera de concebir y gestionar el conflicto, desembocan en la creación de diferentes organismos como los centros de conciliación, la aplicación de fórmulas y técnicas para la solución de conflictos, el desarrollo de propuestas desde entes administrativos a nivel distrital y las nuevas disposiciones que plantea la Ley 115 sobre Gobierno Escolar y manuales de convivencia.

  15. Detailing magnetic field strength dependence and segmental artifact distribution of myocardial effective transverse relaxation rate at 1.5, 3.0, and 7.0 T.

    Science.gov (United States)

    Meloni, Antonella; Hezel, Fabian; Positano, Vincenzo; Keilberg, Petra; Pepe, Alessia; Lombardi, Massimo; Niendorf, Thoralf

    2014-06-01

    Realizing the challenges and opportunities of effective transverse relaxation rate (R2 *) mapping at high and ultrahigh fields, this work examines magnetic field strength (B0 ) dependence and segmental artifact distribution of myocardial R2 * at 1.5, 3.0, and 7.0 T. Healthy subjects were considered. Three short-axis views of the left ventricle were examined. R2 * was calculated for 16 standard myocardial segments. Global and mid-septum R2 * were determined. For each segment, an artifactual factor was estimated as the deviation of segmental from global R2 * value. The global artifactual factor was significantly enlarged at 7.0 T versus 1.5 T (P = 0.010) but not versus 3.0 T. At 7.0 T, the most severe susceptibility artifacts were detected in the inferior lateral wall. The mid-septum showed minor artifactual factors at 7.0 T, similar to those at 1.5 and 3.0 T. Mean R2 * increased linearly with the field strength, with larger changes for global heart R2 * values. At 7.0 T, segmental heart R2 * analysis is challenging due to macroscopic susceptibility artifacts induced by the heart-lung interface and the posterior vein. Myocardial R2 * depends linearly on the magnetic field strength. The increased R2 * sensitivity at 7.0 T might offer means for susceptibility-weighted and oxygenation level-dependent MR imaging of the myocardium. Copyright © 2013 Wiley Periodicals, Inc.

  16. A Devil in the Details: Matrix-Dependent 40Ca42Ca++/42Ca+ and Its Effects on Estimates of the Initial 41Ca/40Ca in the Solar System

    Science.gov (United States)

    McKeegan, K. D.; Liu, M.-C.

    2015-07-01

    Ian Hutcheon established that the molecular ion interference 40Ca42Ca++/42Ca+ on 41K+ is strongly dependent on the mineral analyzed. Correction for this "matrix effect" led to a downward revision of the initial 41Ca/40Ca of the solar system.

  17. Hemorragia alveolar como complicación del uso de trombolíticos

    Directory of Open Access Journals (Sweden)

    Alejandra González

    2011-12-01

    Full Text Available La trombolisis se usa como estrategia de reperfusión coronaria en el infarto agudo de miocardio. El sangrado es su principal complicación; la mayoría ocurre en los sitios de accesos venosos y es leve, pero también pueden presentarse hemorragia gastrointestinal, retroperitoneal, genitourinaria, pulmonar y a nivel del sistema nervioso central, episodios estos generalmente de mayor gravedad y a veces fatales. Se describe aquí el caso de un paciente que recibió terapia trombolítica con estreptoquinasa como tratamiento por un infarto de miocardio, y que posteriormente desarrolló insuficiencia respiratoria aguda, infiltrados pulmonares bilaterales, caída del hematocrito y aumento de la difusión de monóxido de carbono, cuadro compatible con diagnóstico de hemorragia alveolar.

  18. Lattice Dynamics of fcc Ca

    DEFF Research Database (Denmark)

    Stassis, C.; Zaretsky, J.; Misemer, D. K.;

    1983-01-01

    A large single crystal of FCC Ca was grown and was used to study the lattice dynamics of this divalent metal by coherent inelastic neutron scattering. The phonon dispersion curves were measured, at room temperature, along the [ξ00], [ξξ0], [ξξξ], and [0ξ1] symmetry directions. The dispersion curves...... to the propagation of elastic waves. The frequencies of the T1[ξξ0] branch for ξ between approximately 0.5 and 0.8 are slightly above the velocity-of-sound line determined from the low-frequency measurements. Since a similar effect has been observed in FCC Yb, it is natural to assume that the anomalous dispersion...... bear a striking resemblance to those of FCC Yb, which is also a divalent metal with an electronic band structure similar to that of Ca. In particular, the shear moduli c44 and (c11-c 12)/2 differ by a factor of 3.4, which implies that FCC Ca (like FCC Yb) is very anisotropic with regard...

  19. Intranets como apoyo a la gestión del conocimiento Banco Central de Costa Rica

    OpenAIRE

    Giralt Amador, Franklin

    2013-01-01

    A inicios del siglo XXI, las sociedades están experimentando cambios importantes impulsados por el acelerado desarrollo de la tecnología y su amplio campo de acción que impacta la mayoría las actividades humanas ya sea de forma directa o indirecta. Ha sido, en gran parte, la responsable de que las barreras del tiempo y de la distancia hayan caído y que, como muchos autores afirman, el mundo se haya vuelto plano. La información y el conocimiento generado se difunden a grandes ve...

  20. Radio universitaria: trabajo en red como imperativo

    Directory of Open Access Journals (Sweden)

    Tiziana Cavallo

    2014-01-01

    Full Text Available Trabajo en red es un concepto clave en la radio universitaria, tanto desde el punto de vista individual como del colectivo. A través de dos estudios de caso, enfocados en la radio universitaria de Italia y de Colombia, este artículo muestra cómo el trabajo en red ha sido decisivo para el fortalecimiento de su función, la ampliación de su impacto, la conformación de su identidad y el crecimiento de su visibilidad en las sociedades en las cuales desarrollan su labor.

  1. La fatiga como estado motivacional subjetivo

    Directory of Open Access Journals (Sweden)

    D. Cárdenas

    2017-03-01

    No obstante, la tendencia actual es entender la fatiga como un estado motivacional complejo cuyo origen tiene lugar en numerosos procesos fisiológicos y psicológicos que sirven para regular el esfuerzo y proteger al organismo de daños graves. Los objetivos de la presente revisión narrativa son analizar los diferentes enfoques existentes para el estudio y la explicación de la fatiga, establecer el vínculo con el concepto de carga de entrenamiento y justificar la importancia de evaluar las repercusiones de la carga mental para conseguir una adecuada planificación y control del proceso de entrenamiento.

  2. El cáncer como oportunidad

    OpenAIRE

    Mallo Caamaño, Rocío

    2013-01-01

    El objetivo de este proyecto es el de tratar el tema de la actitud ante el cáncer. El diagnóstico del cáncer es algo devastador para la persona diagnosticada principalmente, además de para sus allegados más cercanos. Apoyo en este trabajo la propuesta del cáncer como una oportunidad; una oportunidad para aprender de la experiencia traumática que éste supone y salir reforzados de la situación.

  3. La idea del Geocoaching como herramienta interdisciplinar

    OpenAIRE

    Grau Martínez, Sergio

    2017-01-01

    Treball Final de Grau en Mestre o Mestra d'Educació Primària. Codi: MP1040. Curs acadèmic: 2016/2017 Con este trabajo se pretende demostrar que existen alternativas activas y dinámicas que favorecen notablemente el aprendizaje significativo y la interdisciplinariedad de algunas asignaturas, en este caso, la educación física y las ciencias sociales y naturales. Para ello, en dicho trabajo se propone utilizar la idea del “geocaching” como base y herramienta para realizar una serie de sesi...

  4. La Beta 2 Microglobulina como Marcador Tumoral.

    OpenAIRE

    Saúco Márquez, Juan José

    2016-01-01

    En el presente trabajo hemos efectuado un estudio acerca del valor que tiene la Beta 2 Microglobulina para ser empleada como marcador tumoral. Esta sustancia es una microproteína que es producida por casi todas las células del organismos excepto los eritrocitos y las células trofoblásticas, es liberada a la circulación y es filtrada a nivel glomerular siendo reabsorbida por los túbulos renales en cuyas células es catabolizada y degradada ha...

  5. La indiferencia como instrumento de poder

    Directory of Open Access Journals (Sweden)

    Sergio Carlos Staude

    2014-10-01

    Full Text Available La indiferencia como respuestaante las situaciones de horror queprovoca la guerra llega a adquirirdiferentes funciones. Puede ser unindicador del resguardo necesariopara tramitar lo traumático de losacontecimientos, también un modode desmentir la responsabilidad deestos o bien ser un instrumentosiniestro de poder destinado agarantizar la eficacia de quienesejercen la violencia, neutralizar lasrespuestas del medio social y marginarlas reacciones posibles de lasvíctimas. Se destacan los recursosque aportan el psicoanálisis, lacreación ficcional del arte y, en particular,los esfuerzos de legitimaciónde la justicia para paliar los efectosiatrogénicos de la indiferencia.

  6. La entrevista como encuentro de subjetividades

    Directory of Open Access Journals (Sweden)

    Emma Ruiz Martín del Campo

    2003-01-01

    Full Text Available Se parte de la comprensión de la subjetividad como la expresión preñada de cultura de cada ser humano que se gesta en las relaciones interpersonales, primero entre el infante y las personas que le prodigan los cuidados tempranos, y después en la adolescencia y la edad adulta, con cada vez más representantes de la cultura de la socialización. En dicha interacción, la persona aprende a convivir con otros y a modelar sus impulsos, lo que le permite encontrar las formas más satisfactorias posibles de experimentarse a sí misma y tomar parte en las actividades de su entorno social. El equilibrio entre el individuo que busca satisfacer sus impulsos y necesidades y la cultura a la que pertenece es dinámico, por lo que la subjetividad se transforma a lo largo de toda la vida. Tras abundar sobre la subjetividad, se describen dos formas de orientar la entrevista a profundidad: la psicoanalítica y la etnopsicoanalítica. La entrevista psicoanalítica explora la subjetividad como tal y en ella el entrevistador actúa como un acompañante del sujeto en la progresiva comprensión de sí mismo y de su historia individual, desentrañando significados del comportamiento hasta entonces inconscientes para sí mismo, que se clarifican en la interacción. La entrevista etnopiscoanalítica busca explorar la experiencia cultural de las personas. Expertos en ciencias sociales entrenados a la vez en el descubrimiento del inconsciente se involucran en un medio cultural nuevo para ellos y a través de entrevistas y conversaciones con los integrantes de la comunidad que visitan van descubriendo formas de participación de estos en los espacios de vida social, así como las maneras que dan cuenta de símbolos y modos de reacción propios de su cultura. Cada una de estas dos formas de entrevista es ilustrada con un ejemplo que da muestra plásticamente del encuentro de las subjetividades

  7. No tomar lo real como real

    Directory of Open Access Journals (Sweden)

    Jean Baudrillard

    2015-01-01

    Full Text Available El problema de la comunicación es hoy el de los medios de comunicación. La comunicación en sí ya no tiene tanto sentido. El aparato tecnológico que debería jugar un rol de intermediario en realidad no es un intermediario sino una especie de obstáculo en la relación comunicativa. Vale decir que los medios se autonomizan como una especie de aparato autorreferencial, que se desarrolla por sí mismo y pierde de vista su finalidad y se vuelve proliferante.

  8. Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization.

    Science.gov (United States)

    Kim, Eun Young; Rumpf, Christine H; Van Petegem, Filip; Arant, Ryan J; Findeisen, Felix; Cooley, Elizabeth S; Isacoff, Ehud Y; Minor, Daniel L

    2010-12-01

    Interactions between voltage-gated calcium channels (Ca(V)s) and calmodulin (CaM) modulate Ca(V) function. In this study, we report the structure of a Ca(2+)/CaM Ca(V)1.2 C-terminal tail complex that contains two PreIQ helices bridged by two Ca(2+)/CaMs and two Ca(2+)/CaM-IQ domain complexes. Sedimentation equilibrium experiments establish that the complex has a 2:1 Ca(2+)/CaM:C-terminal tail stoichiometry and does not form higher order assemblies. Moreover, subunit-counting experiments demonstrate that in live cell membranes Ca(V)1.2s are monomers. Thus, contrary to previous proposals, the crystallographic dimer lacks physiological relevance. Isothermal titration calorimetry and biochemical experiments show that the two Ca(2+)/CaMs in the complex have different properties. Ca(2+)/CaM bound to the PreIQ C-region is labile, whereas Ca(2+)/CaM bound to the IQ domain is not. Furthermore, neither of lobes of apo-CaM interacts strongly with the PreIQ domain. Electrophysiological studies indicate that the PreIQ C-region has a role in calcium-dependent facilitation. Together, the data show that two Ca(2+)/CaMs can bind the Ca(V)1.2 tail simultaneously and indicate a functional role for Ca(2+)/CaM at the C-region site.

  9. Multiple Ca2+ sensors in secretion

    DEFF Research Database (Denmark)

    Walter, Alexander M; Groffen, Alexander J; Sørensen, Jakob Balslev

    2011-01-01

    Regulated neurotransmitter secretion depends on Ca(2+) sensors, C2 domain proteins that associate with phospholipids and soluble N-ethylmaleimide-sensitive fusion attachment protein receptor (SNARE) complexes to trigger release upon Ca(2+) binding. Ca(2+) sensors are thought to prevent spontaneous...

  10. An inhibitory effect of extracellular Ca2+ on Ca2+-dependent exocytosis.

    Directory of Open Access Journals (Sweden)

    Wei Xiong

    Full Text Available AIM: Neurotransmitter release is elicited by an elevation of intracellular Ca(2+ concentration ([Ca(2+](i. The action potential triggers Ca(2+ influx through Ca(2+ channels which causes local changes of [Ca(2+](i for vesicle release. However, any direct role of extracellular Ca(2+ (besides Ca(2+ influx on Ca(2+-dependent exocytosis remains elusive. Here we set out to investigate this possibility on rat dorsal root ganglion (DRG neurons and chromaffin cells, widely used models for studying vesicle exocytosis. RESULTS: Using photolysis of caged Ca(2+ and caffeine-induced release of stored Ca(2+, we found that extracellular Ca(2+ inhibited exocytosis following moderate [Ca(2+](i rises (2-3 µM. The IC(50 for extracellular Ca(2+ inhibition of exocytosis (ECIE was 1.38 mM and a physiological reduction (∼30% of extracellular Ca(2+ concentration ([Ca(2+](o significantly increased the evoked exocytosis. At the single vesicle level, quantal size and release frequency were also altered by physiological [Ca(2+](o. The calcimimetics Mg(2+, Cd(2+, G418, and neomycin all inhibited exocytosis. The extracellular Ca(2+-sensing receptor (CaSR was not involved because specific drugs and knockdown of CaSR in DRG neurons did not affect ECIE. CONCLUSION/SIGNIFICANCE: As an extension of the classic Ca(2+ hypothesis of synaptic release, physiological levels of extracellular Ca(2+ play dual roles in evoked exocytosis by providing a source of Ca(2+ influx, and by directly regulating quantal size and release probability in neuronal cells.

  11. Collective flow in central Ca + Ca and Nb + Nb collisions

    International Nuclear Information System (INIS)

    Fai, G.; Csernai, L.P.; Kapusta, J.I.

    1986-01-01

    Questions related to the entropy, equation of state and collective flow of nuclear matter are important to the authors understanding of high energy nuclear collisions. Completion of the analysis of exclusive measurements on central Ca + Ca and Nb + Nb collisions triggered renewed interest in these problems. In order to address the results of exclusive measurements, however, the complex multifragment final states of high energy nuclear collisions need to be incorporated in a theoretical description. The microcanonical event generator model provides statistically generated complete events that can be compared to the exclusive data on an event-by-event basis. To describe the disassembly of hot nuclear matter the model uses an approximate scheme in which the available final states are populated according to their microcanonical weight in phase space. This statistical description is front-ended with simple geometric ideas to divide the collision system into subsystems and with a prescription to share energy and momentum among the subsystems. Any physical quantity of interest is in principle calculable in the model if sufficient statistics is accumulated

  12. Guatemala como alternativa de desarrollo local

    Directory of Open Access Journals (Sweden)

    Rosa Elba Hernandez Cruz

    2015-01-01

    Full Text Available El área aledaña a la Reserva de la biósfera del Volcán Tacaná, en Chiapas México destaca por la producción de café, además de una alta diversidad de flora y fauna; sin embargo las comunidades rurales que habitan estos espacios están en constante búsqueda de alternativas productivas para mejorar sus medios de vida y cuidar el ambiente el cual está sufriendo deterioro. Ante esta situación se planteó como objetivo la integración de una red de fincas agroecoturísticas en los municipios de Cacahoatán, Tuxtla Chico, Unión Juárez en Chiapas, México y una comunidad en Guatemala. Para construir la propuesta se utilizó la metodología de modos de vida, se realizaron talleres participativos, recorridos en campo y se identificaron los productos turísticos. Se concluye, a partir del análisis de los modos de vida, que la región presenta características y oportunidades para desarrollar la red de agroecoturismo como una alternativa económica.

  13. Marañón como modelo

    Directory of Open Access Journals (Sweden)

    Gracia, Diego

    2013-02-01

    Full Text Available As a result of his consistent attitude as citizen and doctor and his “liberal spirit”, Marañón has gone down in the history of the twentieth century as an archetype. Marañón was, above all, a moralist in the Kantian sense, an autonomous person not governed by external criteria but by duty; a thinker convinced of the transforming role of the positive sciences, towards a happier and more just society through a deep intellectual reform. Marañón, like Fernando de los Rios, integrated Kraussism, neo-Kantianism and socialism and from this ideological platform sought the necessary moral change in the Spanish people.Marañón ha pasado a la historia del siglo XX como arquetipo, debido a su actitud coherente y a su “talante liberal”. Marañón fue, sobre todo, un moralista en el sentido kantiano. Una persona autónoma que no se rigió por criterios externos, sino por deber; un convencido del papel transformador de las ciencias positivas en pos de una sociedad más feliz y más justa gracias a una profunda reforma intelectual. Marañón, como Fernando de los Ríos, integró krausismo, neokantismo y socialismo y desde esa plataforma ideológica, propugnó el necesario cambio moral del pueblo español.

  14. Las comunidades locales como estructuras meso.

    Directory of Open Access Journals (Sweden)

    Ferrand, Alexis

    2002-09-01

    Full Text Available Entre el nivel micro y el nivel macro: meso. Si el nivel macro está definido por la regulación nacional, estatal o del mercado y el nivel micro por la regulación interpersonal, una agencia de regulación intermediaria de mayor importancia ha sido definida como “comunidad local” (Wellman, Fischer. Aparte de las dimensiones organizacionales (organizaciones locales, clubes, tiendas... e institucionales (poder local, partidos... locales, es posible definir algunas propiedades estructurales pertinentes de los sistemas de relaciones interpersonales privadas: uno es el grado de “cerrado” (closure local (Barnes: redes locales vs. transversales, o la “dualidad” de estos sistemas. Apoyándose en la idea de que la eficiencia de los “puentes” reside en el tipo de cliques que conectan (Lin, es posible definir tipos variados de micro-estructuras, cuyas distribuciones en diferentes localidades son indicadores sucedáneos o aproximaciones de las diferentes meso estructuras de sistemas relacionales como combinaciones de redes “locales” y “no locales”.

  15. Tecnologia como fundamento do cuidar em Neonatologia

    Directory of Open Access Journals (Sweden)

    José Antonio de Sá Neto

    2010-01-01

    Full Text Available Se trata de un artículo sobre la evolución histórica de la tecnología en neonatología, resaltando aspectos conceptuales y reflexivos sobre el impacto tecnológico en el proceso de cuidar. A pesar de que en los últimos años, la tecnología ha contribuido para mejorar la supervivencia de prematuros extremos nacidos con muy bajo peso, algunas veces da lugar a una modalidad de atención mecánica e impersonal, que se contrapone a cuestiones de índole ética y humana. Se propone una discusión crítica y reflexiva acerca del uso de la tecnología en el cuidado neonatal, destacando sus implicaciones y adecuaciones a las necesidades del recién nacido. Se concluyó que lo que determina si una tecnología es buena o mala, si deshumaniza, despersonaliza o interpreta como objeto al sujeto a cuidar, es la manera como es utilizada, convirtiéndose en imprescindible el perfeccionamiento y la actualización de los profesionales de la salud. En este ejercicio análitico es necesario reflexionar acerca de nuevas maneras de brindar cuidados, utilizando el arte, la sensibilidad y la creatividad en la adaptación y humanización de las tecnologías.

  16. Quitina y carboximetilquitosana como agentes desintegrantes

    Directory of Open Access Journals (Sweden)

    Sol A Fernández Monagas

    1998-08-01

    Full Text Available Se realizó un estudio comparativo de la quitina y la carboximetilquitosana como agentes desintegrantes, y se evaluó la influencia ejercida por el método empleado en la elaboración de las tabletas sobre la actividad desintegrante de ambos polímeros. La quitina presentó buenas características como agente desintegrante independientemente del método utilizado en la elaboración de las tabletas, mientras que la actividad desintegrante de la carboximetilquitosana fue afectada por el proceso de granulación.A comparative study of chitin and carboxymethylchitosan as disintegrating agents was wade made. The influence exerted bu tje method used in the preparation of the tablets on the disintegrating activity of both polymers was evaluated. Chitin proved to have good characteristics as a disintegrating agent independently of the method used to make tablets. The disintegrating activity of carboxymethylchitosan was affected by the granulation process.

  17. El lenguaje como instrumento de poder

    Directory of Open Access Journals (Sweden)

    MARÍA TERESA SUÁREZ GONZÁLEZ

    2009-01-01

    Full Text Available La investigación denominada 'El lenguaje como instrumento de poder' planteó dos interrogantes que permitieron, por un lado, evidenciar ¿cuáles estrategias discursivas permiten analizar la relación entre lenguaje y poder en el discurso de la segunda posesión del presidente Álvaro Uribe Vélez y, por otro, analizar las implicaciones que tienen las mencionadas estrategias en la construcción de sentido. Lo anterior con el fin de mirar cómo se ejerce poder mediante las prácticas discursivas, dado que quien emite un discurso busca, ante todo, convencer y cambiar la mentalidad de los receptores, a través de la comunicación de creencias, actitudes, valores y un sinnúmero de saberes tomados de su entorno y de la cultura, por medio de estrategias discusivas que son empleadas de manera consciente, de acuerdo con el fin que se persiga. Teniendo en cuenta lo anterior, esta ponencia presenta los resultados obtenidos en la investigación, desarrollada en la Maestría en Lingüística de la UPTC, los cuales muestran el discurso como una interacción a través de la cual se evidencian marcas de poder y se construyen los acontecimientos y las identidades de los sujetos, mediante la comunicación.

  18. Bloque de tierra comprimida como material constructivo

    Directory of Open Access Journals (Sweden)

    Óscar Javier Gutiérrez Junco

    2011-07-01

    Full Text Available La construcción con tierra es poco usada en la actualidad debido a la falta de difusión e investigación, y a que es relacionada con la pobreza; por ende, se desaprovechan muchas de sus ventajas, como la abundancia demateria prima, la localización, la disponibilidad, el reciclaje, la producción sin consumo de energía (calorífica, el bajo costo y la resistencia –con un adecuado estudio del material tierra, de la estructuración y del suelo de fundación–; otras de sus ventajas son el aislamiento térmico y acústico. Con el paso del tiempo se han mejorado las técnicas constructivas con tierra, realizando estabilizaciones e implementando el uso de maquinaria y herramienta mecánica para elaborar bloques de tierra comprimida, y así facilitar el trabajo y obtener mayor rendimiento. Este artículo presenta la tierra como material constructivo, las técnicas o sistemas constructivos, los bloques de tierra comprimida (BTC y algunos ensayos realizados a estos bloques.

  19. El manual como texto Schoolbook as text

    Directory of Open Access Journals (Sweden)

    Agustín Escolano Benito

    2012-12-01

    Full Text Available Este trabajo aborda la cuestión de la identidad del libro escolar como un género textual específico en el contexto de la manualística clásica y moderna, contextualizando los análisis en el marco de la cultura de la escuela tradicional y en la era de la revolución digital y bajo una perspectiva historiográfica y teórica. También plantea el nacimiento y primeros desarrollos de la manualística como campo intelectual y académico y sus contribuciones a la definición de la identidad del libro escolar.This paper discusses the question of identifying a coursebook as a specific text genre in the context of the classical and modern manualistics, situating the analysis within the traditional school culture and the digital revolution era, under a historical and theoretical perspective. It also covers the birth and initial development of manualistics as an intelectual and academic field and its contributions to the definition of the schoolbook identity.

  20. EVALUACIÓN AMBIENTAL PARA PROCESOS QUE USAN RESIDUOS DE LA INDUSTRIA DE LOS BIOCOMBUSTIBLES COMO MATERIAS PRIMAS

    Directory of Open Access Journals (Sweden)

    Mónica Julieth Valencia Botero

    Full Text Available La industria creciente de los biocombustibles genera grandes cantidades de residuos que tienen alto potencial para la obtención de productos con alto valor agregado. En el presente documento se lleva a cabo el análisis de ciclo de vida (ACV para el glicerol y el bagazo de caña de azúcar durante su producción y para su uso como materia prima en cuatro procesos diferentes. El objetivo fue determinar el impacto ambiental de los cuatro procesos, por medio de la cuantificación de gases de efecto invernadero (GEI asociados al ciclo de vida. Los resultados indican que las emisiones de GEI asociadas a los procesos que utilizan el glicerol como materia prima son mayores que las emisiones de GEI para los procesos que involucran bagazo de caña de azúcar, pero que el aprovechamiento del glicerol podría considerarse más eficiente, ya que las emisiones por unidad de masa en el uso del glicerol son 75% inferiores a las emisiones calculadas para los procedimientos utilizando bagazo de caña como materia prima.

  1. Divalent metal (Ca, Cd, Mn, Zn) uptake and interactions in the aquatic insect Hydropsyche sparna.

    Science.gov (United States)

    Poteat, Monica D; Díaz-Jaramillo, Mauricio; Buchwalter, David B

    2012-05-01

    Despite their ecological importance and prevalent use as ecological indicators, the trace element physiology of aquatic insects remains poorly studied. Understanding divalent metal transport processes at the water-insect interface is important because these metals may be essential (e.g. Ca), essential and potentially toxic (e.g. Zn) or non-essential and toxic (e.g. Cd). We measured accumulation kinetics of Zn and Cd across dissolved concentrations ranging 4 orders of magnitude and examined interactions with Ca and Mn in the caddisfly Hydropsyche sparna. Here, we provide evidence for at least two transport systems for both Zn and Cd, the first of which operates at concentrations below 0.8 μmol l(-1) (and is fully saturable for Zn). We observed no signs of saturation of a second lower affinity transport system at concentrations up to 8.9 μmol l(-1) Cd and 15.3 μmol l(-1) Zn. In competition studies at 0.6 μmol l(-1) Zn and Cd, the presence of Cd slowed Zn accumulation by 35% while Cd was unaffected by Zn. At extreme concentrations (listed above), Cd accumulation was unaffected by the presence of Zn whereas Zn accumulation rates were reduced by 58%. Increasing Ca from 31.1 μmol l(-1) to 1.35 mmol l(-1) resulted in only modest decreases in Cd and Zn uptake. Mn decreased adsorption of Cd and Zn to the integument but not internalization. The L-type Ca(2+) channel blockers verapamil and nifedipine and the plasma membrane Ca(2+)-ATPase inhibitor carboxyeosin had no influence on Ca, Cd or Zn accumulation rates, while Ruthenium Red, a Ca(2+)-ATPase inhibitor, significantly decreased the accumulation of all three in a concentration-dependent manner.

  2. El eco de la caída de Constantinopla en las literaturas hispánicas

    OpenAIRE

    Díaz-Mas, Paloma

    2003-01-01

    Se ofrece una panorámica de las obras literarias que recogen la caída de Constantinopla en poder de los turcos en 1453, atendiendo tanto a la literatura castellana como a la catalana, en el contexto de las literaturas románicas.

  3. Las javieradas como caso de estudio

    Directory of Open Access Journals (Sweden)

    Mª Cruz Porcal Gonzalo

    2006-01-01

    Full Text Available A pesar de su todavía modesta participación en la economía y en el empleo regional, el turismo en Navarra ha mostrado durante los últimos años un significativo dinamismo tal y como, por ejemplo, lo testimonia el incremento del número de visitantes y de las empresas turísticas. Favorecido por una serie de circunstancias de índole variada, este desarrollo turístico se sustenta en una gran diversidad geográfica y cultural patente en los paisajes, el arte, las fiestas, la gastronomía, etc. Pero Navarra es, a su vez, una región que secularmente ha otorgado un gran peso a la tradición y a las creencias religiosas. En este contexto, algunas de las numerosas acciones emprendidas por la administración regional para dinamizar el sector turístico se han encaminado a revalorizar dos importantes legados culturales: el castillo de Javier y el Camino de Santiago. Se aprecia que ambos se hallan estrechamente relacionados con el turismo cultural, el turismo religioso y las peregrinaciones, unos fenómenos que hunden sus raíces en tiempos pasados pero que continúan teniendo en la actualidad una indudable relevancia a escala mundial. La intención primordial del presente trabajo es analizar el turismo de peregrinaciones en Navarra, más concretamente, el que tiene como destino del viaje la cuna de San Francisco Javier. Con dicho afán, se realiza una reflexión conceptual previa y un breve repaso de las fiestas y tradiciones religiosas que forman parte del patrimonio cultural intangible de Navarra, haciendo particular hincapié en las romerías y en el Camino de Santiago. Al hilo de ello, se afronta, a continuación, el estudio de la peregrinación más singular y populosa de Navarra: la Javierada. Su origen, sus principales rasgos, el perfil y las motivaciones de los peregrinos, los caracteres e hitos más importantes del recorrido, las peculiaridades del destino —entendido como lugar sagrado y espacio turístico— constituyen las principales

  4. Arquitectura como percepción

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    Mañana Borrazás, Patricia

    2003-12-01

    Full Text Available This text sets out to illustrate types of basic analysis in researching a question as intrinsically human as perception. In the analysis of a construction, the aspects relative to perception allow us to access interesting information as to how a construction functions and what is implied by its different spaces, information which is in direct relation to more human, living aspects of architecture. These analyses complement formal analyses, as while these allow us to describe a construction in time and space, analyses of perception seek to stress the existing relationship between the human being and the construction, understanding architecture as a physical element to be experienced and which has been constructed to create a favourable atmosphere for certain perceptions. The study first shows the most basic elements in perception analysis and how these support a methodology that attempts to understand a construction in all its aspects (formal, social, symbolic, giving as an example a Neolithic Galician burial mound.Este texto trata de ilustrar los tipos de análisis básicos para investigar una cuestión tan intrínsecamente humana como la percepción. En el análisis de una construcción, los aspectos relativos a la percepción nos permiten acceder a una interesante información de cómo una construcción funciona y qué implican sus distintos espacios, información en directa relación con los aspectos más humanos y vivenciales de la arquitectura. Son unos análisis complementarios a los análisis formales, ya que mientras estos nos permiten describir en el espacio y en el tiempo una construcción, los análisis de percepción tratan de incidir en la relación existente entre el ser humano y la construcción, entendiendo a la arquitectura también como elemento físico a experimentar y que ha sido construido para propiciar ciertas percepciones. Se exponen en primer lugar las claves más básicas de los análisis de percepción y cómo estos se

  5. Hydrolysis of molten CaCl2-CaF2 with additions of CaO

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    Espen Olsen

    2017-10-01

    Full Text Available Calcium halide based molten salts have recently attracted interest for a number of applications such as direct reduction of oxides for metal production and as liquefying agent in cyclic sorption processes for CO2 by CaO from dilute flue gases (Ca-looping. A fundamental aspect of these melts is the possible hydrolysis reaction upon exposure to gaseous H2O forming corrosive and poisonous hydrogen halides. In this work experiments have been performed investigating the formation of HCl and HF from a molten salt consisting of a 13.8 wt% CaF2 in CaCl2 eutectic exposed to a flowing gas consisting of 10 vol% H2O in N2. Hydrolysis has been investigated as function of content of CaO and temperature. HCl and HF are shown to be formed at elevated temperatures; HCl forms to a substantially larger extent than HF. Addition of CaO has a marked, limiting effect on the hydrolysis. Thermodynamic modeling of the reaction indicates activity coefficients for CaO above unity in the system. For cyclic CO2-capture based on thermal swing, it is advisable to keep the temperature in the carbonation (absorption reactor well below 850 ℃ while maintaining a high CaO content if molten CaCl2 is employed. Similar conclusions can be drawn with regards to CaF2.

  6. Como Perseu se defendeu de Medusa?

    Directory of Open Access Journals (Sweden)

    Rose Lumertz de Freitas

    2012-04-01

    Full Text Available Na psicanálise francesa, principalmente com Lacan, o conceito de falta passou a ser de grande importância. Ao que, então, perguntamos: o que é a falta? E quando esta falta? O que acontece? O que acontece quando o não especularizável não está excluído, se fazendo, assim, especular? Quando Perseu vai ao encontro de Medusa, guiando-se por sua imagem refletida em um espelho de bronze polido, segurado por Atena, como pôde este herói defender-se de Medusa? Qual foi a forma encontrada por ele para se defender da presença do objeto que introduz a dimensão do real nu?

  7. La cultura como verdad: pobreza latinoamericana

    Directory of Open Access Journals (Sweden)

    Ana María Rocchietti

    2000-04-01

    Full Text Available El artículo parte de un balance crítico de la obra Antropología de la Pobreza, del antropólogo Oscar Lewis para analizar el concepto de pobreza en América Latina. Se argumenta que la cultura de la pobreza ofrece la posibilidad de incluir a las formaciones simbólicas de las tradiciones vivientes y a las que emergen en la existencia comunitaria de los pobres como un factor de peso en la evolución de las relaciones de fuerza entre las clases subalternas y las clases dominantes; entre los sectores populares rurales y urbanos y los gobiernos; entre las formaciones sociales nacionales y el imperialismo.

  8. Hume: a teoria social como sistema

    Directory of Open Access Journals (Sweden)

    Rolf Kuntz

    2011-12-01

    Full Text Available Hume defende na Investigação sobre o Entendimento Humano a parcimônia no uso de princípios explicativos. Tenta-se mostrar, neste artigo, como ele procurou seguir essa diretriz em seus trabalhos sobre os sentimentos morais, a história, a política e a economia. Explora-se, ao mesmo tempo, o caráter sistemático do projeto enunciado no começo do Tratado da Natureza Humana.In his Enquiry on Human Understanding Hume proposes a rule of parcimony in the use of explanatory principles. This essay is an attempt to show how the philosopher managed to follow that rule in his writings on moral sentiments, history, politics and economics. At the same time, it explores the systematic character of the project described in the presentation of the Treatise on Human Nature.

  9. Photoemission study of Ca-intercalated graphite superconductor CaC6

    International Nuclear Information System (INIS)

    Okazaki, Hiroyuki; Yoshida, Rikiya; Iwai, Keisuke; Noami, Kengo; Muro, Takayuki; Nakamura, Tetsuya; Wakita, Takanori; Muraoka, Yuji; Hirai, Masaaki; Tomioka, Fumiaki; Takano, Yoshihiko; Takenaka, Asami; Toyoda, Masahiro; Oguchi, Tamio; Yokoya, Takayoshi

    2010-01-01

    In this work, we have performed resonant photoemission studies of Ca-intercalated graphite superconductor CaC 6 . Using photon energy of the Ca 2p-3d threshold, the photoemission intensity of the peak at Fermi energy (E F ) is resonantly enhanced. This result provides spectroscopic evidence for the existence of Ca 3d states at E F , and strongly supports that Ca 3d state plays a crucial role for the superconductivity of this material with relatively high T c .

  10. El atal como ambiente de aprendizaje inclusivo

    Directory of Open Access Journals (Sweden)

    Inmaculada González Falcón

    2017-04-01

    Full Text Available En las últimas décadas la creciente llegada de población inmigrantes en España ha generado la determinación de nuevas políticas educativas de escolarización para el alumnado de origen extranjero. En la comunidad andaluza, se destaca la creación del “Aula Temporal de Aceleración Lingüística” para la promoción de la enseñanza de la lengua vehicular y la integración socioeducativa del alumnado de origen extranjero. El trabajo que aquí se presenta forma parte de proyecto nacional I+D+I (Ref. CSO2013-43266-R sobre las trayectorias de estos dispositivos. Este artículo se formula bajo un doble objetivo: por un lado, analizar las variables didácticas que se desarrollan en las ATAL de dos centros públicos de educación secundaria de la provincia onubense; y por otro, valorar las semejanzas y disonancias entre dichas aulas a través de un estudio etnográfico, explicitando de igual modo los condicionantes en cuanto a tres ejes de análisis: física-funcional, temporal y relacional. Los resultados se dirigen hacia el reconocimiento del aula como espacio de apoyo emocional y de atención personal desde la configuración de ambientes de aprendizaje. Este hecho evidencia la reflexión hacia modelos educativos que conformen un marco de actuación intercultural como generadores de la inclusión para el alumnado extranjero en los centros educativos.

  11. Taxonomia como elemento estruturante em portais corporativos

    Directory of Open Access Journals (Sweden)

    Luciane Paula Vital

    2012-01-01

    Full Text Available Este trabalho busca discutir os objetivos e requisitos necessários a um portal corporativo e de que forma a construção de uma taxonomia possibilita atingi-los, configurando-se em um modelo de representação da informação e do conhecimento nesse contexto. Apresenta a evolução das intranets em direção aos portais, construindo um ponto de acesso comum as informações organizacionais. Apresenta uma revisão sobre as funcionalidades que um portal corporativo deve apresentar. Conceitua e caracteriza os diferentes tipos de taxonomia e a forma com que organiza e representa a informação. Por fim, apresenta a taxonomia como ferramenta para a determinação de categorias conceituais e de relacionamentos semânticos de uma área, assim como, da estrutura navegacional, permitindo qualificar o processo de recuperação da informação. Palavras-chave Taxonomia. Portais Corporativos. Representação da Informação. Organização da Informação. Abstract This article discusses the objectives and requirements necessary for a corporate portal and how to build a taxonomy allows for to reach them, becoming a model of representation information and knowledge in this context. Shows the evolution of intranets into the portal, building a common access point to information organizational. Presents an overview of the features that an enterprise portal should present. Conceptualizes and describes the different types of taxonomy and the way it organizes and represents information. Finally, the taxonomy as a tool for determining the conceptual categories and semantic relationships of an area, as well as the navigational structure, allowing the process to qualify for retrieval. Keywords Taxonomy. Enterprise Portal. Information Representation. Information Organization.

  12. El paisaje como archivo del territorio

    Directory of Open Access Journals (Sweden)

    Esther Isabel Prada Llorente

    2004-09-01

    (1 Este trabajo es una parte seleccionada sobre un aspecto muy concreto, como es la escala territorial, de la tesis doctoral “Sayago, evolución histórica y proyección futura de su estructura territorial” leída en la Escuela Técnica Superior de Arquitectura de Madrid en octubre de 2002. (2 Sayago: Posible relación con yacimientos mineros de época celta derivando de la palabra céltica Salliacum. Sus formas medievales serían: Saliago, Salago, Salagu y Sayago (cfr. MARTÍN VISO, 1996. De sayo, sayal, capa o “sagum” celtibérico y lusitano de color pardo, buriel o vellorí de las ovejas llamadas negras. Se pagaban como tributos por los vencidos celtíberos a las tribus romanas. Con el “paño sayal” se confeccionaron (hasta finales del s.XIX, principios del XX, todas las prendas externas de la indumentaria sayaguesa (cfr. Del Brío Mateos, 1998. (3 Escuadro: Topónimo de origen romanizador posiblemente referido a algún tipo de parcelación romana (Informante: Juan Vicent, prehistoriador del C.S.I.C. “Ex-cuadro” o “fuera del cuadro”, según la tradición popular este poblamiento hubiera surgido a raíz de los acompañamientos que las tropas romanas necesitaban para su abastecimiento en todos los aspectos, dejando fuera del recinto en otro lugar, al conjunto de herreros, artesanos, prostitutas, etc. que constituían dicho acompañamiento

  13. O PRODUTO COMO CAUSADOR DE ACIDENTES

    Directory of Open Access Journals (Sweden)

    Widomar Carpes Jr

    2004-06-01

    Full Text Available Neste artigo analisa-se a contribuição dos produtos para a geração de acidentes, apresentando-se estatísticas de acidentes de trabalho, de trânsito e aeronáuticos. Além disso, para melhor ilustrar a relação entre produtos e a ocorrência de acidentes, alguns casos de acidentes ocorridos e divulgados pela mídia são comentados. As estatísticas e os casos comentados demonstram a importância do estudo dos acidentes envolvendo produtos, evidenciando que praticamente todos os acidentes estão relacionados com o uso de produtos industrializados. Então, se analisa histórica e criticamente as principais teorias de acidentes de trabalho, porque são as únicas teorias existentes em relação aos acidentes. Além delas, são analisados os diversos conceitos sobre o erro humano e sua ocorrência, pois estes são apontados como grandes causadores de acidentes. Nesta análise, se observa que os acidentes estão mais relacionados aos perigos ou às características perigosas dos produtos do que às atitudes e ao comportamento do usuário. Faz-se uma revisão dos conceitos associados aos acidentes, tais como perigo, risco, acidente e dano, a partir dos quais apresenta-se um fluxograma contendo os elementos necessários para a manifestação dos acidentes. Ao final, conclui-se que a participação dos produtos na ocorrência de acidentes é evidente e que o comportamento do usuário é dependente das características do produto e da situação na qual ele é utilizado.

  14. El desarrollo organizacional como facilitador del cambio

    Directory of Open Access Journals (Sweden)

    Henry Molina

    2000-01-01

    Full Text Available El Desarrollo Organizacional (DO ha surgido de las exigencias de un ambiente cambiante y del conocimiento originado por la evolución de las ciencias sociales aplicadas. Los cambios rápidos dentro del entorno organizacional han exigido procesos y estructuras organizacionales que sean mucho más flexibles y que brinden mayor capacidad de respuesta que las estructuras tradicionales. Se requieren nuevas capacidades individuales y organizacionales que puedan impulsar las iniciativas individuales y la disposición para asumir riesgos. Igualmente, debemos considerar que existen marcadas diferencias entre las características individuales de los gerentes, las características individuales de los profesionales del desarrollo organizacional, sus habilidades y conocimientos y los estilos de las intervenciones del desarrollo organizacional. Tbdas estas diferencias hacen que sea virtualmente imposible predecir con precisión el curso y los resultados de las intervenciones en las organizaciones cliente. En este documento presento un resumen de lecturas acerca del desarrollo organizacional como facilitador del cambio; y expongo un marco de referencia para la comprensión de los factores determinantes de la relación entre las intervenciones del DO y los cambios organizacionales con el fin de mejorar la predictabilidad y la efectividad de los esfuerzos de cambio de sus intervenciones. El propósito central de este documento es dotar a los agentes de cambio de conocimiento y herramientas para que comprendan las características del cambio, los métodos de aprendizaje tanto de las organizaciones como de la gente y de cómo los agentes de cambio deben diseñar sus intervenciones y posteriormente mejorar los resultados de las mismas

  15. Como reescribir funciones aleatorias multivariadas como univariadas para hacer cokrigeage. La teoría

    Directory of Open Access Journals (Sweden)

    Adrian Martínez-Vargas

    2010-03-01

    Full Text Available En el año 2005 Martínez-Vargas formuló un sistema de cokrigeage puro heterotópico para estimar una función aleatoria regionalizada (RF Z*(x definida como la combinación lineal de n RF's univariadas Zi(x, cuyos coeficientes 1i(x son indicatrices de un set disyuntivo de categorías i. Aparentemente este modelo se contradice pues asume que las covarianzas cruzadas existen en un mismo punto, a pesar de su carácter puramente heterotópico. Para evadir dicha contradicción se redefinió el set de RF Zi(x como una única RF Z(x,i, siendo los puntos (x,i y (x,j no coincidentes si i y j no son iguales. La heterotopía fue simplemente considerada como una omisión de la RF Z(x,. en los datos y en los puntos a estimar, no impuesta por el modelo; entonces el resultado es simplemente un caso particular del cokrigeage clásico. Con esta notación se reescribió el sistema de cokrigeage clásico como el sistema de krigeage de la RF univariada Z(x,i, asumiendo que esta posee un drift definido como m(x,i,j, donde los miembros fl(x,i,j de m(x,i,j pueden ser linealmente dependientes o independientes. Bajo esta notación el sistema de krigeage se reduce a un sistema univariado, la existencia de más de una variable o la presencia de heterotropía no impone la necesidad de manipulaciones extras para definir el sistema de ecuaciones de krigeage, incrementándose la eficiencia computacional.

  16. Evaluation of the potential of additives as corrosion inhibitors of CA-50 carbon steel used as reinforcement in concretes; Avaliacao da potencialidade de aditivos como inibidores de corrosao do aco carbono CA-50 usado como armadura de estruturas de concreto

    Energy Technology Data Exchange (ETDEWEB)

    Mennucci, Marina Martins

    2006-07-01

    In this work, various compounds were tested to evaluate their potential capability for their use as corrosion inhibitors of carbon steel reinforcement in concretes. The additives tested were sodium benzoate, polyethylene glycol, hexamethylenetetramine, benzotriazole and yttrium carbonate. Initially, exploratory tests were carried out to select the ones to be used as corrosion inhibitors, based on the inhibit ion efficiency determined from electrochemical tests, specifically polarization tests and electrochemical impedance spectroscopy. These tests were carried out in a solution composed of 0.01 N sodium hydroxide (NaOH) and 0.05 N potassium hydroxide (KOH) to simulate the composition of the solution inside the pores in concretes. The additive that presented the most promising potential to be used as corrosion inhibitor was benzotriazole (BTA). After the elimination of some compounds and selection of the additive with higher corrosion inhibit ion efficiency in the test medium, the effect of its concentration on the corrosion inhibition efficiency was evaluated. Sodium nitrite solutions with the same concentrations as those solutions with BTA were tested for comparison reasons. Sodium nitrite is a well established corrosion inhibitor for carbon steel reinforcement in concretes but it has been related to toxic effects. The BTA was associated to higher corrosion inhibition efficiencies than that of sodium nitrite in similar concentrations. A blackish adherent film was formed on the steel surface exposed to BTA solutions during long periods of immersion in the alkaline medium. The results suggest that BTA is a potential candidate for substitution of nitrites as corrosion inhibitor of reinforcements in concrete. (author)

  17. Ca2+/cation antiporters (CaCA: Identification, characterization and expression profiling in bread wheat (Triticum aestivum L.

    Directory of Open Access Journals (Sweden)

    Mehak Taneja

    2016-11-01

    Full Text Available The Ca2+/cation antiporters (CaCA superfamily proteins play vital function in Ca2+ ion homeostasis, which is an important event during development and defense response. Molecular characterization of these proteins has been performed in certain plants, but they are still not characterized in Triticum aestivum (bread wheat. Herein, we identified thirty four TaCaCA superfamily proteins, which were classified into TaCAX, TaCCX, TaNCL and TaMHX protein families based on their structural organization and evolutionary relation with earlier reported proteins. Since the T. aestivum comprises an allohexaploid genome, TaCaCA genes were derived from each A, B and D subgenome and homeologous chromosome (HC, except chromosome-group 1. Majority of genes were derived from more than one HCs in each family that were considered as homeologous genes (HGs due to their high similarity with each other. These HGs showed comparable gene and protein structures in terms of exon/intron organization and domain architecture. Majority of TaCaCA proteins comprised two Na_Ca_ex domains. However, TaNCLs consisted of an additional EF-hand domain with calcium binding motifs. Each TaCaCA protein family consisted of about ten transmembrane and two α-repeat regions with specifically conserved signature motifs except TaNCL, which had single α-repeat. Variable expression of most of the TaCaCA genes during various developmental stages suggested their specified role in development. However, constitutively high expression of a few genes like TaCAX1-A and TaNCL1-B indicated their role throughout the plant growth and development. The modulated expression of certain genes during biotic (fungal infections and abiotic stresses (heat, drought, salt suggested their role in stress response. Majority of TaCCX and TaNCL family genes were found highly affected during various abiotic stresses. However the role of individual gene needs to be established. The present study unfolded the opportunity

  18. Ca2+/Cation Antiporters (CaCA): Identification, Characterization and Expression Profiling in Bread Wheat (Triticum aestivum L.).

    Science.gov (United States)

    Taneja, Mehak; Tyagi, Shivi; Sharma, Shailesh; Upadhyay, Santosh Kumar

    2016-01-01

    The Ca 2+ /cation antiporters (CaCA) superfamily proteins play vital function in Ca 2+ ion homeostasis, which is an important event during development and defense response. Molecular characterization of these proteins has been performed in certain plants, but they are still not characterized in Triticum aestivum (bread wheat). Herein, we identified 34 TaCaCA superfamily proteins, which were classified into TaCAX, TaCCX, TaNCL, and TaMHX protein families based on their structural organization and evolutionary relation with earlier reported proteins. Since the T. aestivum comprises an allohexaploid genome, TaCaCA genes were derived from each A, B, and D subgenome and homeologous chromosome (HC), except chromosome-group 1. Majority of genes were derived from more than one HCs in each family that were considered as homeologous genes (HGs) due to their high similarity with each other. These HGs showed comparable gene and protein structures in terms of exon/intron organization and domain architecture. Majority of TaCaCA proteins comprised two Na_Ca_ex domains. However, TaNCLs consisted of an additional EF-hand domain with calcium binding motifs. Each TaCaCA protein family consisted of about 10 transmembrane and two α-repeat regions with specifically conserved signature motifs except TaNCL, which had single α-repeat. Variable expression of most of the TaCaCA genes during various developmental stages suggested their specified role in development. However, constitutively high expression of a few genes like TaCAX1-A and TaNCL1-B indicated their role throughout the plant growth and development. The modulated expression of certain genes during biotic (fungal infections) and abiotic stresses (heat, drought, salt) suggested their role in stress response. Majority of TaCCX and TaNCL family genes were found highly affected during various abiotic stresses. However, the role of individual gene needs to be established. The present study unfolded the opportunity for detail

  19. Measurements of natural 41Ca concentrations

    International Nuclear Information System (INIS)

    Steinhof, A.

    1989-05-01

    Atomic mass spectroscopic examinations on 41 Ca were carried out in the UNILAC accelerator. A sensitivity of about 10 -15 was achieved. This would allow the measurement of present natural 41 Ca concentrations as soon as the problem of the transmission determination is solved. In this respect suggestions were worked out and their feasibility discussed. The detection of 41 Ca-ions is especially free of background when high UNILAC-energies are applied. An estimation showed a background level corresponding with a 41 Ca concentration of less then 10 -17 referred to 40 Ca. Besides an independent concept for the electromagnetic concentration of 41 Ca with variable concentration factors was developed. After being concentrated up to 50 respectively 25 times the initial concentration in the GSI mass separator, the 41 Ca concentration of three recent deer bones found in the Odenwald was measured by atomic mass spectroscopy in the 14UD-Pelletron Tandem in Rehovot (Israel). The measured 41 Ca concentrations ranged between 10 -14 to 10 -13 with consideration of the concentration factor. A theoretical study of the 41 Ca production in the earth's surface based on cosmic radiation illustrates the influence of trace elements on the neutron flux and thus on the 41 Ca production. This influence might be a possible explanation for the observed amplitude of variation of the 41 Ca concentration in recent bones which are of decisive importance for the feasibility of 41 Ca-related dating. In this work a method is suggested that does not depend on the amplitude of variation mentioned above and which would allow the determination of the erosion rate of rocks by its 41 Ca concentrations. (orig./HP) [de

  20. Bax regulates neuronal Ca2+ homeostasis.

    Science.gov (United States)

    D'Orsi, Beatrice; Kilbride, Seán M; Chen, Gang; Perez Alvarez, Sergio; Bonner, Helena P; Pfeiffer, Shona; Plesnila, Nikolaus; Engel, Tobias; Henshall, David C; Düssmann, Heiko; Prehn, Jochen H M

    2015-01-28

    Excessive Ca(2+) entry during glutamate receptor overactivation ("excitotoxicity") induces acute or delayed neuronal death. We report here that deficiency in bax exerted broad neuroprotection against excitotoxic injury and oxygen/glucose deprivation in mouse neocortical neuron cultures and reduced infarct size, necrotic injury, and cerebral edema formation after middle cerebral artery occlusion in mice. Neuronal Ca(2+) and mitochondrial membrane potential (Δψm) analysis during excitotoxic injury revealed that bax-deficient neurons showed significantly reduced Ca(2+) transients during the NMDA excitation period and did not exhibit the deregulation of Δψm that was observed in their wild-type (WT) counterparts. Reintroduction of bax or a bax mutant incapable of proapoptotic oligomerization equally restored neuronal Ca(2+) dynamics during NMDA excitation, suggesting that Bax controlled Ca(2+) signaling independently of its role in apoptosis execution. Quantitative confocal imaging of intracellular ATP or mitochondrial Ca(2+) levels using FRET-based sensors indicated that the effects of bax deficiency on Ca(2+) handling were not due to enhanced cellular bioenergetics or increased Ca(2+) uptake into mitochondria. We also observed that mitochondria isolated from WT or bax-deficient cells similarly underwent Ca(2+)-induced permeability transition. However, when Ca(2+) uptake into the sarco/endoplasmic reticulum was blocked with the Ca(2+)-ATPase inhibitor thapsigargin, bax-deficient neurons showed strongly elevated cytosolic Ca(2+) levels during NMDA excitation, suggesting that the ability of Bax to support dynamic ER Ca(2+) handling is critical for cell death signaling during periods of neuronal overexcitation. Copyright © 2015 the authors 0270-6474/15/351706-17$15.00/0.

  1. Comparative study of anisotropic superconductivity in CaAlSi and CaGaSi

    International Nuclear Information System (INIS)

    Tamegai, T.; Uozato, K.; Kasahara, S.; Nakagawa, T.; Tokunaga, M.

    2005-01-01

    In order to get some insight into the origin of the anomalous angular dependence of H c2 in a layered intermetallic compound CaAlSi, electronic, superconducting, and structural properties are compared between CaAlSi and CaGaSi. The angular dependence of H c2 in CaGaSi is well described by the anisotropic GL model. Parallel to this finding, the pronounced lattice modulation accompanying the superstructure along the c-axis in CaAlSi is absent in CaGaSi. A relatively large specific heat jump at the superconducting transition in CaAlSi compared with CaGaSi indicates the presence of strong electron-phonon coupling in CaAlSi, which may cause the superstructure and the anomalous angular dependence of H c2

  2. Ca2+ cycling in heart cells from ground squirrels: adaptive strategies for intracellular Ca2+ homeostasis.

    Directory of Open Access Journals (Sweden)

    Xiao-Chen Li

    Full Text Available Heart tissues from hibernating mammals, such as ground squirrels, are able to endure hypothermia, hypoxia and other extreme insulting factors that are fatal for human and nonhibernating mammals. This study was designed to understand adaptive mechanisms involved in intracellular Ca(2+ homeostasis in cardiomyocytes from the mammalian hibernator, ground squirrel, compared to rat. Electrophysiological and confocal imaging experiments showed that the voltage-dependence of L-type Ca(2+ current (I(Ca was shifted to higher potentials in ventricular myocytes from ground squirrels vs. rats. The elevated threshold of I(Ca did not compromise the Ca(2+-induced Ca(2+ release, because a higher depolarization rate and a longer duration of action potential compensated the voltage shift of I(Ca. Both the caffeine-sensitive and caffeine-resistant components of cytosolic Ca(2+ removal were more rapid in ground squirrels. Ca(2+ sparks in ground squirrels exhibited larger amplitude/size and much lower frequency than in rats. Due to the high I(Ca threshold, low SR Ca(2+ leak and rapid cytosolic Ca(2+ clearance, heart cells from ground squirrels exhibited better capability in maintaining intracellular Ca(2+ homeostasis than those from rats and other nonhibernating mammals. These findings not only reveal adaptive mechanisms of hibernation, but also provide novel strategies against Ca(2+ overload-related heart diseases.

  3. A AUTOESTIMA COMO ALIADA DO PROCESSO ENSINOAPRENDIZAGEM

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    Gonçalina dos Santos

    2013-06-01

    Full Text Available O presente trabalho caracteriza-se como um desdobramento de um projeto de pesquisa da Universidade Estadual do Norte Fluminense (UENF, sobre o estudo de um olhar sobre objetos de aprendizagem como metodologia no ensino da matemática à luz da teoria dos registros de representação semiótica. Nosso trabalho visa verificar a influência da aplicação desta metodologia de ensino na autoestima dos educandos. Essa pesquisa foi desenvolvida dentro do método qualitativo e quantitativo descritivo exploratório, tendo a natureza do objeto e dos objetivos propostos neste estudo. A pesquisa foi realizada no Colégio Maria de Nazaré na Cidade do Rio de Janeiro, onde os alunos responderam o questionário de autoestima de Rosenberg (1989. A pesquisa foi composta por dois grupos um de análise experimental e outro de controle. No Brasil a temática da autoestima é pouco abordada cientificamente. Palavra fácil na psicologização das relações humanas. Por auto-estima entende-se a avaliação que o indivíduo faz de si mesmo. Expressa uma atitude de aprovação ou de repulsa de si e engloba o auto-julgamento em relação à competência e valor Em relação às pequenas diferenças apresentadas nos resultados encontrados nos grupo experimental, há dificuldade em se afirmar categoricamente a questão. Ao avaliar a média do grupo de controle no inicio da pesquisa, encontrava-se em 49,28% de autoestima, no final este mesmo grupo apresenta uma redução para 48,23%de autoestima. Já ao avaliar a média do grupo experimental no inicio da pesquisa este encontrava-se com 47,5% de autoestima, obtendo um aumento para 49,5% após a inserção do objeto de aprendizagem nas aulas.

  4. Como una enfermedad. La escritura y la filosofía según Wittgenstein

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    Michael Wood

    2010-01-01

    Full Text Available Comenzando por algunos comentarios de Giorgio Agamben sobre la relación entre la poesía y la prosa, y por su evocación de la sugerencia de Wittgenstein de que la filosofía debería ser escrita como si fuera poesía, este ensayo explora algunos de los posibles sentidos de escribir filosofía de dicha manera y concluye que el lenguaje literario, tal como se encuentra en la prosa y el pensamiento de Wittgenstein, tiene tres características esenciales: requiere y grati!ca la interpretación; utiliza modismos y otras formas retóricas como argumentación; y la forma de lo dicho es parte esencial de lo que se dice. Starting from some remarks by Giorgio Agamben on the relation between poetry and prose, and from his invocation of Wittgenstein’s recommendation that philosophy should be written as if it were poetry, this essay explores some of the possible meanings of writing philosophy in this way, and concludes that literary language, as exempli!ed in Wittgenstein’s thought and prose, has three essential features: it requires and rewards extensive in terpretation; it uses figures of speech and other rhetorical features as modes of argument; and the form of its saying is an essential part of what is said. What are the consequences for philosophy of such a de!nition?

  5. CaELEjeros: el estudiante como etnógrafo para el desarrollo de la Competencia Comunicativa Intercultural

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    Yeray González Plasencia

    2017-11-01

      Abstract: this paper offers an approach to integrate Intercultural Communicative Competence into S/FL through ethnographic practices. The objective of the proposal is to produce an audiovisual report on a specific cultural fact, taking the famous Spanish programme Callejeros as a textual model. The didactic proposal is organized in five phases: approximation, introduction, deepening, consolidation and co-evaluation, in which the student works individually, in groups and in collaboration with the teacher. Finally, it is exposed that this methodology promotes autonomous and integral learning, given that it promotes the development of both linguistic and communicative skills as well as affective, procedural and cognitive strategies. A proposal that encourage the student's critical awareness in a highly motivating framework. Keywords: intercultural communicative competence, ethnography, Spanish culture, audiovisual report.

  6. Quando um primitivo é como um orbe? Quando um primitivo é como um orbe?

    Directory of Open Access Journals (Sweden)

    J. Hillis Miller

    2008-04-01

    Full Text Available Minhas estratégias de analise textual se tornarão mais ou menos evidentes na leitura que se segue. Sua proveniência deveriam tornar-se & cia. 0 ensaio foi inicialmente pensado come parte do livro The Linguistic Moment (Princeton: Princeton University Press, 1985. Aqui, como no livro, minha preocupação maior e com aqueles momentos em poemas em que a poesia como meio de comunicação constitui problema. Interessa-me particularmente a forma pela qual as fronteiras entre a linguagem conceitual e a figurative se tornam pouco visiveis no poema "A Primitive like an Orb", da última fase da poesia de Wallace Stevens.

  7. ESPACIOS RENATURALIZADOS COMO AMBIENTES DE APRENDIZAJE

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    Yenny Rosas

    2015-12-01

    Los espacios renaturalizados, se consolidan como ambientes de aprendizaje para el ejercicio de la ciudadanía y la convivencia, a partir del desarrollo de metodologías participativas y haciendo uso de tecnologías apropiadas. Para ello se diseñaron e implementaron una serie de sesiones, con el fin de contribuir a la transformación del entorno y de permitir la conectividad ecológica presente en el ecosistema estratégico ubicado allí mismo, además de consolidar experiencias en el desarrollo de capacidades ciudadanas esenciales. Para la institución educativa se construyó, un jardín agroecológico y se sembraron árboles con fines productivos y ornamentales, permitiendo de esa manera la generación de identidad con respecto a los espacios renaturalizados, la estructura ecológica, además de reconocer las relaciones socio-ecológicas que alrededor de estos espacios se desarrollan. Entorno a la intervención, se construyeron conocimientos propios del currículo, además se identificaron las problemáticas ambientales propias de la zona, permitiendo de esa manera la armonización de la relación naturaleza-cultura y la adaptación ecosistémica al cambio climático, que requiere la ciudad de Bogotá.

  8. De como os alunos entendem os textos

    Directory of Open Access Journals (Sweden)

    Peronard Th, Marianne

    1991-01-01

    Full Text Available Nosso interesse na compreensão do texto escrito apresenta uma tendência pedagógica. Tal perspectiva guiou a seleção de nossa estrutura teórica, os limites de nosso trabalho experimental e a natureza dos instrumentos que usamos, tanto durante a avaliação das habilidades de compreensão dos alunos como durante as aplicações instrucionais. Nosso foco tem se localizado na compreensão inferencial, a qual medimos pedindo aos estudantes que verbalizassem as inferências necessárias para conbstruir uma interpretação coerente. Para garantir uma sanidade ecológica, temos nos mantido o mais próximo possível de uma situação escolar, um fato que, em resumo, parece ter sido autodestruidor. Nossos resultados mostram fracas habilidades de compreensão por parte dos sujeitos (aproximadamente 2600 alunos. Suas respostas manifestam pouco raciocínio inferencial e suas estratégias, baixa adaptação à estrutura ou conteúdo do texto. De fato a estratégia mais comum parece ser a que nós chamamos de "estratégia lexical restrita", que é mais uma "estratégia de resposta" do que uma estratégia de compreensão

  9. El budismo como una espiritualidad no religiosa

    Directory of Open Access Journals (Sweden)

    Marta Granés Bayona

    2014-09-01

    Full Text Available El budismo plantea acceder a una visión de la realidad desligada de creencias y supuestos de todo tipo. Para conseguirlo plantea una indagación libre en referencia al enclaustramiento de nuestro pensar y sentir al que nos somete el ego. El ego con sus necesidades y deseos genera un acceso a la realidad relativo a nosotros. Lo que se propone es una liberación de esta lectura para que la realidad pueda aparecer frente a nosotros de manera independiente de las imposiciones del ego, es decir, un acceso a ella ab-soluto (suelto de nosotros. El budismo es, pues, una propuesta de ‘espiritualidad no religiosa’, para la que el mismo término espiritualidad  resultaría inadecuado porque en él subyace la creencia en el ‘espíritu’. Vemos que por todo ello el mensaje budista resulta muy apropiado para las sociedades hoy presentes, bien para aquellas que están transitando de una sociedad agrícola a una industrial, que conlleva a debilitar las convicciones religiosas hasta disolverlas; bien para aquellas que están próximas o han entrado ya en las sociedades llamadas de conocimiento, innovación y cambio continuo cuya condición de movilidad impide  las creencias, porque son fijadoras, lo que arrastra como consecuencia la imposibilidad de tener religión ni espiritualidad. 

  10. Como obter vantagem competitiva utilizando business intelligence?

    Directory of Open Access Journals (Sweden)

    Avanilde Kemczinski

    2003-03-01

    Full Text Available Este artigo tem por objetivo definir Business Intelligence e identificar as tecnologias de informação e comunicação que dão suporte a este tipo de sistema de informação. Faz-se uma contextualização sobre o conceito e as tipologias de sistemas de informação (SI. Data Warehouse, Data Mart e Data Mining são os recursos tecnológicos denominados de Back-end system, utilizados para armazenar dados relevantes e extrair padrões de comportamento e tendências dos processos organizacionais. Os DSS (Decision Support Systems, EIS (Executive Information Systems e ferramentas de OLAP (On-Line Analytical Processing são caracterizados como Front-end systems para os sistemas de Business Intelligence, requerendo-se ampla funcionalidade, flexibilidade e usabilidade para que o usuário possa fazer a transformação das informações em conhecimento estratégico que apóie a tomada de decisão organizacional, objetivando a vantagem competitiva. Palavras-chave: Sistemas de Informação, Business Intelligence, Data Mining, Data Warehouse, OLAP.

  11. Daimien Hirst : el artista como preparador

    Directory of Open Access Journals (Sweden)

    Nike Verena Fakiner

    2006-01-01

    Full Text Available El cuerpo más allá de su razón biológica, es un espacio de proyección donde se escenifican las normas y los valores socioculturales y científicos. La ciencia médica constituye un régimen escópico, en cuyo marco se construye un imaginario acerca del cuerpo, que modela y normaliza la percepción que el sujeto moderno establece con él. Hirst trabaja desde el cuerpo muerto, como medio y material de trabajo, para cuestionar el posicionamiento del cuerpo en el discurso de la medicina. Para ello se sirve de imágenes corporales situadas en la frontera entre Medicina y Arte.The body, beyond its biological meaning, is a space of projection of cultural and scientific norms and values. The medicine constitutes a scopic regime, where an imaginary of body is built up which normalizes its perception by the modern subject. Hirst works with the dead body as medium and material of work, in order to question body` s position in medicine discourse. Therefore, he works with body images placed on the border line between Medicine and Art.

  12. La moneda como ofrenda en los manantiales

    Directory of Open Access Journals (Sweden)

    Manuel Abad Varela

    1992-01-01

    Full Text Available A la vista de como se han producido la mayoría de los hallazgos analizados y según se desprende de las fuentes escritas, diríamos que en la península ibérica y sobre todo en la parte Occidental se realizaron en la Antigüedad ofrendas monetales a divinidades de las aguas y fundamentalmente, por las referencias que tenemos, a las divinidades de las fuentes termales. Únicamente nos queda la duda de si la fuente de Peña Cutral en Retortillo (Reinosa, Santander es termal o no, pues si no lo fuese sería el único hallazgo dentro de una fuente no termal. Se podría entender, con ciertos reparos en algún caso, que también se hicieron arrojándolas al curso de los ríos, depositándolas en la orilla y lanzándolas a las charcas o pantanos. Por otro lado, las monedas que se han encontrado en las fuentes, en contraposición con las recogidas en los ríos, suelen estar en muy mala conservación, hasta el punto de que muchas se desintegran en las manos al estar muy atacadas por los ácidos. A juzgar por algunos de los hallazgos, se podría creer que las ofrendas más valiosas se procuró depositarlas en lugares seguros o resguardados, como es el caso de la Hermida, de la Fuente de El Sarso, del Balneario de Fortuna y podríamos recordar también el hallazgo del conocido depósito de Oñate. De acuerdo con la cronología de las monedas y según sus resultados estadísticos, la costumbre o rito de depositar o arrojar «stips» a las aguas, principalmente termales, se practicó en la península Ibérica más intensamente entre los siglos i a. C. al ii d. C. Este período coincide con el momento que más estuvo en boga el uso de las aguas termales, a juzgar por lo que se trató el tema en las fuentes escritas. Al mismo tiempo que se percibe esta moda en la vida diaria, pues Suetonio nos dice que Augusto, a pesar de que por su naturaleza enfermiza no abusaba de los baños, sin embargo, cuando necesitaba templar los nervios tomaba baños de mar o las

  13. Josep Beuys : el arte como creencia y como salvación

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    María López Ruido

    1995-01-01

    Full Text Available Joseph Beuys, nacido en Cléveris (Renania del Norte-Westfalia en 1921 y faliecido en Dusseldorf en 1986, posee una obra madura casi desde un primer momento. Superficialmente podríamos verla como el canto a sí mismo de un gran narcisista, donde sus experiencias y su persona son los grandes protagonistas. En una lectura más profunda, estos hechos personales no son más que el medio para ir más allá del yo y dar lugar a una creación plástica de trascendencia social. Tras la 2- Guerra Mundial, en la que lucha como piloto de la Luftwaffe, estudia en la Academia de Bellas Artes de Dusseldorf. Será a partir de los años 60 cuando encontremos al auténtico Beuys, escultor objetual e instalador, el creador de la plástica social, y desde sus contactos con Fluxus en 1962, el Beuys accionista. En los 70, se nos presenta el artista más claramente politizado. La educación, la incidencia social del arte, el arte como «tercera vía o vía alternativa» entre socialismo y capitalismo, la ecología serán sus materiales de trabajo.

  14. El dinero como acto de habla y como conjunto de funciones de status: aportaciones a una ontología del dinero

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    Joan González Guardiola

    2012-03-01

    Full Text Available En su polémica obra de 1995, The construction of social reality, John Searle presentaba una “nueva ontología de la realidad social” que, a menudo, utilizaba el dinero como ejemplo de sus análisis constitutivos. Uno de los aspectos que alguna crítica losó ca desarrolló con más intensidad respecto a las tesis de Searle en aquel libro era la posibilidad (que Searle negaba de que existieran objetos sociales independientes de base material (free – standing Y terms. Después de diversos artículos polémicos al respecto, Searle presentó, en el año 2010, una revisión y reexposición de sus concepciones al respecto (Making the social world, en la cual creía poder superar los elementos críticos de su anterior exposición (principalmente vinculados a algunos malentendidos respecto al alcance de la fórmula constitutiva “X cuenta como Y en C” postulando el principio según el cual “todos los hechos institucionales, y por consiguiente todas las funciones de status, son creadas por actos de habla del tipo de las “declaraciones””. El ob- jetivo del presente artículo consiste en mostrar que la reexposición de la teoría de Searle no permite llevar a cabo ningún avance en el terreno de la ontología del dinero siempre que no se modi que sustancialmente su concepción sobre la génesis del dinero, que hace surgir el dinero como objeto social a partir de la función de medio de cambio. Sin una revisión profunda del “relato genético” sobre el dinero que Searle mantenía en 1995 (muy próximo a lo que se puede considerar “análisis ortodoxo” en teoría monetaria, la nueva presentación del dinero como acto de habla aparece llena de tensiones entre el nivel constitutivo y el nivel genético, de manera que las potencialidades de una teoría del dinero como acto de habla se desvanecen.

  15. Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak

    Science.gov (United States)

    Sankaranarayanan, Rajiv; Li, Yatong; Greensmith, David J.; Eisner, David A.

    2016-01-01

    Key points Ca leak from the sarcoplasmic reticulum through the ryanodine receptor (RyR) reduces the amplitude of the Ca transient and slows its rate of decay.In the presence of β‐adrenergic stimulation, RyR‐mediated Ca leak produces a biphasic decay of the Ca transient with a fast early phase and a slow late phase.Two forms of Ca leak have been studied, Ca‐sensitising (induced by caffeine) and non‐sensitising (induced by ryanodine) and both induce biphasic decay of the Ca transient.Only Ca‐sensitising leak can be reversed by traditional RyR inhibitors such as tetracaine.Ca leak can also induce Ca waves. At low levels of leak, waves occur. As leak is increased, first biphasic decay and then slowed monophasic decay is seen. The level of leak has major effects on the shape of the Ca transient. Abstract In heart failure, a reduction in Ca transient amplitude and contractile dysfunction can by caused by Ca leak through the sarcoplasmic reticulum (SR) Ca channel (ryanodine receptor, RyR) and/or decreased activity of the SR Ca ATPase (SERCA). We have characterised the effects of two forms of Ca leak (Ca‐sensitising and non‐sensitising) on calcium cycling and compared with those of SERCA inhibition. We measured [Ca2+]i with fluo‐3 in voltage‐clamped rat ventricular myocytes. Increasing SR leak with either caffeine (to sensitise the RyR to Ca activation) or ryanodine (non‐sensitising) had similar effects to SERCA inhibition: decreased systolic [Ca2+]i, increased diastolic [Ca2+]i and slowed decay. However, in the presence of isoproterenol, leak produced a biphasic decay of the Ca transient in the majority of cells while SERCA inhibition produced monophasic decay. Tetracaine reversed the effects of caffeine but not of ryanodine. When caffeine (1 mmol l−1) was added to a cell which displayed Ca waves, the wave frequency initially increased before waves disappeared and biphasic decay developed. Eventually (at higher caffeine concentrations), the

  16. Como Lo Hago Yo: Mielomeningocele En Bolivia

    Science.gov (United States)

    Dabdoub, Carlos F.; Dabdoub, Carlos B.; Villavicencio, Ramiro; Quevedo, Germán

    2014-01-01

    Introducción: Las malformaciones del tubo neural (MTN) representan la segunda causa más frecuente de anomalías congénitas, luego de las cardiopatías. En este grupo se destaca el mielomeningocele (MMC) por su mayor incidencia, y por ser la más incapacitante y la más compleja entre todas las demás malformaciones del sistema nervioso c`entral (SNC). En Bolivia, como en muchos países de Sudamérica, los bajos niveles socio-culturales y la debilidad en el sistema sanitario, hacen que su incidencia y su morbilidad, sean mayores que en las naciones más desarrolladas. Material y Métodos: Se realizó un estudio retrospectivo y descriptivo de 70 casos de MMC, atendidos por un equipo multidisciplinario en el Hospital Universitario Japonés (HUJ) de Santa Cruz de la Sierra, entre 2008-2011. De ellos, 60 fueron intervenidos quirúrgicamente. Resultados: Se realizaron controles prenatales sólo en 27 mujeres (38.6%), diagnosticándose una disrafia espinal en apenas dos casos (7.4%). La edad de ingreso del MMC en su mayoría fue después de las 24 horas (65.6%), predominando su localización en la región lumbosacra (64.3%). De ellos, 67.2% eran abiertos, presentando un 32.9% un daño neurológico motor parcial mientras que 47.1% tenían paraplejia por debajo de la lesión. De los 70 casos, tres (4.3%) no fueron intervenidos, por presentar defectos congénitos severos o estado general grave. Las principales complicaciones posoperatorias inmediatas fueron: dehiscencia de sutura y/o infección de la herida (16.6%), fístula de líquido cefalorraquídeo (LCR) (10%) e infección del SNC (11.7%). La mortalidad general y postoperatoria fue de 7.1% y 3.3%, respectivamente. Al mes de vida presentaban hidrocefalia un 80% de los pacientes operados, colocándose una derivación ventriculoperitoneal (DVP) de presión media. De 9 pacientes que tuvieron un acompanamiento de dos o más años, seis presentaron una médula anclada, que fueron intervenidas quirúrgicamente. Conclusi

  17. La participacion ciudadana como fuente de democracia

    Directory of Open Access Journals (Sweden)

    Orlando José Cadrazco Salcedo

    2009-01-01

    Full Text Available Resumen:La Participación ciudadana es un órgano de deliberación donde confluyen todos los factores reales de poder paradecidir sobre aspectos como el plan de desarrollo, plan de ordenamiento territorial y presupuesto (atendiendo alente territorial donde se establezca , en sí este modelo es un verdadero desarrollo del concepto de democraciaparticipativa que consagra nuestra Carta Política, es un ejemplo de que la soberanía popular consagrada en elartículo tercero de la Carta va más allá del formalismo legalista y los intrincados vericuetos de la ley 134 de 1994que nunca han permitido que se ponga en marcha un verdadero desarrollo de la democracia participativa, y quepor fin salgamos de ese esquema retrogrado de la representatividad y por supuesto que a través de este modelolleguemos a un verdadero contrato social que provenga de las bases.Palabras claves:Democracia Participativa. Carta Politica, Sociedad, Participaciòn Ciudadana, Modelo Democrático, ConstituciónPolítica.Abstract:Citizen participation is a deliberative body where all the real power to decide on aspects such as the developmentplan, development plan and budget (according to the local authority where it is established, this model is itself atrue development the concept of participatory democracy enshrined in our Constitution, is an example of popularsovereignty enshrined in the third article of the Charter goes beyond the legal formalities and vericuetos the intricaciesof the law 134 of 1994 which have never been allowed to put ongoing development of a true participatorydemocracy, and they finally get out of this backward scheme of representation and of course that through this modelto create a real social contract comes from the grassroots.Keywords:Participatory Democracy. Charter Politics, Society, Politics, democratic, Constitution.

  18. Teresa Wilms Montt: la visceralidad como activismo

    Directory of Open Access Journals (Sweden)

    Cecilia Macon

    2017-07-01

    Full Text Available Es usual señalar que el debate sobre las emociones solo pasó a formar parte del feminismo en los últimos años. Sin embargo, es notoria la referencia en la literatura feminista de la primera ola al espacio de lo íntimo en términos de una colisión de emociones profundamente política que puede ser definida en términos de “visceralidad”. El presente trabajo se enmarca en un proyecto que tiene como objetivo final señalar el modo en que la transmisión de los afectos formó parte fundamental de la constitución del feminismo en América Latina. Este artículo se ocupa analizar la producción de la escritora chilena Teresa Wilms Montt, muy particularmente su primera obra, “Inquietudes sentimentales” (1917. No se trata meramente de argumentar la presencia de la dimensión emocional, sino de indagar en la especificidad de ese momento de su escritura donde la categoría de ‘intimidad” se torna central a la hora de establecer principios feministas. Son las características de su recorrido -donde entran en colisión las emociones más diversas - y el vínculo que establece con las luchas políticas del feminismo de corte anarquista las que abren la posibilidad de entender esta etapa, dando cuenta de la constitución de una geografía afectiva para el activismo latinoamericano. Una geografía marcada, centralmente por el desafío a “estructuras del sentir” patriarcales a través de intervenciones que sacan a la luz el papel politico de la visceralidad en tanto acción.

  19. Edward C. Little Water Recycling Plant, El Segundo, CA: CA0063401

    Science.gov (United States)

    Joint EPA and Los Angeles Regional Water Quality Control Board NPDES Permit and Waiver from Secondary Treatment for the West Basin Municipal Water District Edward C. Little Water Recycling Plant, El Segundo, CA: CA0063401

  20. Tuberculosis como enfermedad ocupacional Tuberculosis as occupational disease

    OpenAIRE

    Alberto Mendoza-Ticona

    2012-01-01

    Existe evidencia suficiente para declarar a la tuberculosis como enfermedad ocupacional en diversos profesionales especialmente entre los trabajadores de salud. En el Perú están normados y reglamentados los derechos laborales inherentes a la tuberculosis como enfermedad ocupacional, como la cobertura por discapacidad temporal o permanente. Sin embargo, estos derechos aún no han sido suficientemente socializados. En este trabajo se presenta información sobre el riesgo de adquirir tuberculosis ...

  1. Coupled Ca2+/H+ transport by cytoplasmic buffers regulates local Ca2+ and H+ ion signaling.

    Science.gov (United States)

    Swietach, Pawel; Youm, Jae-Boum; Saegusa, Noriko; Leem, Chae-Hun; Spitzer, Kenneth W; Vaughan-Jones, Richard D

    2013-05-28

    Ca(2+) signaling regulates cell function. This is subject to modulation by H(+) ions that are universal end-products of metabolism. Due to slow diffusion and common buffers, changes in cytoplasmic [Ca(2+)] ([Ca(2+)]i) or [H(+)] ([H(+)]i) can become compartmentalized, leading potentially to complex spatial Ca(2+)/H(+) coupling. This was studied by fluorescence imaging of cardiac myocytes. An increase in [H(+)]i, produced by superfusion of acetate (salt of membrane-permeant weak acid), evoked a [Ca(2+)]i rise, independent of sarcolemmal Ca(2+) influx or release from mitochondria, sarcoplasmic reticulum, or acidic stores. Photolytic H(+) uncaging from 2-nitrobenzaldehyde also raised [Ca(2+)]i, and the yield was reduced following inhibition of glycolysis or mitochondrial respiration. H(+) uncaging into buffer mixtures in vitro demonstrated that Ca(2+) unloading from proteins, histidyl dipeptides (HDPs; e.g., carnosine), and ATP can underlie the H(+)-evoked [Ca(2+)]i rise. Raising [H(+)]i tonically at one end of a myocyte evoked a local [Ca(2+)]i rise in the acidic microdomain, which did not dissipate. The result is consistent with uphill Ca(2+) transport into the acidic zone via Ca(2+)/H(+) exchange on diffusible HDPs and ATP molecules, energized by the [H(+)]i gradient. Ca(2+) recruitment to a localized acid microdomain was greatly reduced during intracellular Mg(2+) overload or by ATP depletion, maneuvers that reduce the Ca(2+)-carrying capacity of HDPs. Cytoplasmic HDPs and ATP underlie spatial Ca(2+)/H(+) coupling in the cardiac myocyte by providing ion exchange and transport on common buffer sites. Given the abundance of cellular HDPs and ATP, spatial Ca(2+)/H(+) coupling is likely to be of general importance in cell signaling.

  2. Cuento: Sangre de caña

    Directory of Open Access Journals (Sweden)

    Segundo Benjamín Corredor

    1967-09-01

    Full Text Available El viento se convertía en murmullo contra las hojas de los cañaverales y contra los techos semipelados del rancho. También menguaba el calor que maduraba los plantíos de caña y que hacía más efusiva la sangre de los moradores.

  3. Contabilidade gerencial como apoio ao "just in time"

    OpenAIRE

    Costa, Sérgio De Carvalho

    2010-01-01

    Descreve as técnicas da filosofia "Just in Time" e apresenta as modificações necessárias aos Sistemas Gerencias para que se tornem coerentes com a filosofia JIT, bem como meçam adequadamente a melhoria contínua da Empresa. Critica tanto o Custeio' Direto como o Custeio por Absorção, apresentando como alternativa o Custeio "ABC". Mostra como o JIT facilita o Custeio dos Produtos e destaca os aspectos estratégicos da Avaliação de Desempenho. Finalmente discorre sobre um estudo de...

  4. Impact of seawater [Ca2+] on the calcification and calcite Mg / Ca of Amphistegina lessonii

    NARCIS (Netherlands)

    Mewes, A.; Langer, G.; Thoms, S.; Nehrke, G.; Reichart, G. J.; de Nooijer, L. J.; Bijma, J.

    2015-01-01

    Mg / Ca ratios in foraminiferal tests are routinely used as paleotemperature proxies, but on long timescales, they also hold the potential to reconstruct past seawater Mg / Ca. The impact of both temperature and seawater Mg / Ca on Mg incorporation in Foraminifera has been quantified by a number of

  5. Perspectivas de la cosecha de la caña de azúcar cruda en México

    OpenAIRE

    Ortiz Laurel, Hipólito; Salgado García, Sergio; Castelán Estrada, Mepivoseth; Córdova Sánchez, Samuel

    2012-01-01

    La quema de los cañaverales predomina en la cosecha de la caña de azúcar tanto manual como mecánica. Ésta técnica de quema genera problemas de carácter ambiental, económico, tecnológico y social, por lo que urge impulsar la cosecha de caña "cruda" y simultáneamente introducir tecnologías y metodologías para el manejo y uso rentable y sustentable de los residuos de cosecha. En las pocas zonas de cosecha total mecanizada de caña "cruda", los residuos llegan a representar hasta 26% del rendimien...

  6. Ca-Dependent Folding of Human Calumenin

    Science.gov (United States)

    Mazzorana, Marco; Hussain, Rohanah; Sorensen, Thomas

    2016-01-01

    Human calumenin (hCALU) is a six EF-hand protein belonging to the CREC family. As other members of the family, it is localized in the secretory pathway and regulates the activity of SERCA2a and of the ryanodine receptor in the endoplasmic reticulum (ER). We have studied the effects of Ca2+ binding to the protein and found it to attain a more compact structure upon ion binding. Circular Dichroism (CD) measurements suggest a major rearrangement of the protein secondary structure, which reversibly switches from disordered at low Ca2+ concentrations to predominantly alpha-helical when Ca2+ is added. SAXS experiments confirm the transition from an unfolded to a compact structure, which matches the structural prediction of a trilobal fold. Overall our experiments suggest that calumenin is a Ca2+ sensor, which folds into a compact structure, capable of interacting with its molecular partners, when Ca2+ concentration within the ER reaches the millimolar range. PMID:26991433

  7. CaMKII in the Cardiovascular System: Sensing Redox States

    Science.gov (United States)

    Erickson, Jeffrey R.; He, B. Julie; Grumbach, Isabella M.; Anderson, Mark E

    2013-01-01

    The multifunctional Ca2+ and calmodulin-dependent protein kinase II (CaMKII) is now recognized to play a central role in pathological events in the cardiovascular system. CaMKII has diverse downstream targets that promote vascular disease, heart failure and arrhythmias, so improved understanding of CaMKII signaling has the potential to lead to new therapies for cardiovascular disease. CaMKII is a multimeric serine-threonine kinase that is initially activated by binding calcified calmodulin (Ca2+/CaM). Under conditions of sustained exposure to elevated Ca2+/CaM CaMKII transitions into a Ca2+/CaM-autonomous enzyme by two distinct but parallel processes. Autophosphorylation of threonine 287 in the CaMKII regulatory domain ‘traps’ CaMKII into an open configuration even after Ca2+/CaM unbinding. More recently, our group identified a pair of methionines (281/282) in the CaMKII regulatory domain that undergo a partially reversible oxidation which, like autophosphorylation, prevents CaMKII from inactivating after Ca2+/CaM unbinding. Here we review roles of CaMKII in cardiovascular disease with an eye to understanding how CaMKII may act as a transduction signal to connect pro-oxidant conditions into specific downstream pathological effects that are relevant to rare and common forms of cardiovascular disease. PMID:21742790

  8. Aretafila de Cirene: "armas de mujer" como instrumento de acción política

    Directory of Open Access Journals (Sweden)

    María Dolors Mirón Pérez

    2012-11-01

    Full Text Available La figura de Aretafila es una de las más singulares y complejas de Virtudes de mujeres, de Plutarco (ca. 50 - ca. 120 d. C., donde este presenta una serie de actuaciones de mujeres dignas de recuerdo como ejemplos de virtud femenina. A lo largo del relato, Aretafila se mueve constantemente por los bordes de la transgresión, sumergiéndose en el mundo masculino de la política, aunque mediante el empleo de típicas “armas de mujer” consideradas inquietantes por el pensamiento patriarcal clásico. El final de la historia, sin embargo, supone el “feliz” regreso al buen orden, tanto político como de género; y es mediante él que la hasta entonces transgresora Aretafila es “domesticada” y puede ser mostrada como ejemplo de virtud. Este relato también nos invita a reflexionar acerca de los mecanismos de construcción de la memoria histórica y legendaria cuando la protagonista es una mujer.

  9. Teste tuberculínico. Como optimizar?

    Directory of Open Access Journals (Sweden)

    Raquel Duarte

    2009-03-01

    Full Text Available Resumo: Os testes utilizados no diagnóstico de infecção latente pelo Mycobacterium tuberculosis, o teste tuberculínico e o doseamento do interferão gama (IGRA identificam a existência de uma resposta imunológica adaptativa de memória contra os antigénios micobacterianos. Considerando as limitações dos dois testes, a melhor solução passa por tirar proveito das melhores características de cada um. A maior parte dos autores concorda com a utilização dos dois testes, utilizando os IGRA sobretudo na confirmação da positividade do teste tuberculínico (tirando proveito da sua maior especificidade.As características operativas do teste tuberculínico dependem da prevalência da doença na comunidade e dos objectivos da sua realização (as suas características são superiores quando utilizada no âmbito de rastreio ou como teste diagnóstico. Para interpretar correctamente um teste tuberculínico, o clínico deve conhecer a epidemiologia da tuberculose na comunidade e definir correctamente as indicações para a sua realização. Abstract: The tests used in the diagnosis of tuberculosis latent infection, the tuberculin skin test (TST and the interferon-gamma assays (IGRA, identify the existence of an adaptive immune response towards mycobacterial antigens. Considering the limitations of the two tests, the best solution is to take advantage of the best characteristics of each one. Most of the authors agree to the use of the two tests, using the IGRAS in the confirmation of a positive TST (because of its higher specificity. The operative characteristics of TST depend on the prevalence of the illness in the community and the aim of its use (its operative characteristics are higher when used in the tracing scope or as a diagnostic test. To interpret correctly a TST, the physician must know the epidemiology of tuberculosis in the community and correctly define the indications for its use. Palavras-chave: Tuberculose, teste tubercul

  10. O direito como juízo

    Directory of Open Access Journals (Sweden)

    Denise Maria Weiss de Paula Machado

    1988-07-01

    Full Text Available This study presents a synthetic and personal view of the consequences arising from the notion of law as justice. For Kelsen, in this "Theory of pure law", human conduct produce facts, justly or injust1y, that become characterized as legal norms. Human behavior is determined by acts of reason, that are defined by a representative (a judge, and then are used as valid norms of justice. The conception of law is, therefore, represented by an ideal object, rational and only apprehensible through abstract processes, following the views of Kelsenians. Without any intent to criticize the "great master of Vienna", a search of the text demonstrates that a neutral ideology, concerning the comprehension and application of law, does not and can not exists law can not depart from empirical reality when following its purpose of promoting the liberty and development of society.O presente texto tem por finalidade apresentar uma visão sintética e pessoal das conseqüências decorrentes da noção do direito como juízo. Para KELSEN, em sua "Teoria pura do direito", a conduta humana produz fatos jurídicos ou injurídicos, conforme assim os caracterizam as normas jurídicas. A conduta humana é determinada por uma razão de agir, que é definida pela representação juízo que o homem tem da norma jurídica 'vigente. A concepção do direito é, pois, representada por um objeto ideal, racional e somente apreensível através de um processo de abstração, segundo a visão Kelseniana. Sem a mínima pretensão de formular críticas ao grande Mestre de Viena, procura o texto demonstrar que a neutralidade ideológica, para a compreensão e aplicação do direito, não existe e nem pode existir, eis que o direito não pode se afastar da realidade empírica, a fim de que possa alcançar sua finalidade de promover a libertação e a evolução da sociedade.

  11. El humanismo como paradigma de la enfermería como ciencia

    Directory of Open Access Journals (Sweden)

    Núñez Gómez Nicolás Arturo

    1999-12-01

    Full Text Available

    Humanism's philosophical conception is presented to development a paradigm of nursing science. The nursing from creation has been guided toward professional practice and category; of Care has been fundamental contribution. In this article our intends is to grow some fine general of reflection so that nurses contribute to development of a science called nursing and whose accent is man in their multiple dimensions.

    A partir del humanismo como concepción filosófica se presenta una propuesta para crear un paradigma de la enfermería como ciencia. Desde su creación, la enfermería se ha orientado hacia su práctica profesional y la categoría de cuidado ha sido su aporte fundamental. Este artículo se propone crear unas líneas generales de reflexión, para que las enfermeras aporten al desarrollo de una ciencia llamada enfermería y cuyo acento es el hombre en sus múltiples dimensiones.

  12. El silencio como estrategia en la obra de Juan Rulfo

    OpenAIRE

    Gómez López-Quiñones, Loreto

    2013-01-01

    Juan Rulfo utiliza el silencio como un espacio para oír y decir mejor en el contexto del México postrevolucionario. Inspirándonos en la terminología de Spivak, pretendemos mostrar el silencio de Rulfo como una estrategia de resistencia ante la representación occidental del Otro.

  13. Juvenile Hippocampal CA2 Region Expresses Aggrecan

    Directory of Open Access Journals (Sweden)

    Asako Noguchi

    2017-05-01

    Full Text Available Perineuronal nets (PNNs are distributed primarily around inhibitory interneurons in the hippocampus, such as parvalbumin-positive interneurons. PNNs are also present around excitatory neurons in some brain regions and prevent plasticity in these neurons. A recent study demonstrated that PNNs also exist around mouse hippocampal pyramidal cells, which are the principle type of excitatory neurons, in the CA2 subregion and modulate the excitability and plasticity of these neurons. However, the development of PNNs in the CA2 region during postnatal maturation was not fully investigated. This study found that a main component of PNNs, aggrecan, existed in the pyramidal cell layer of the putative CA2 subarea prior to the appearance of the CA2 region, which was defined by the CA2 marker protein regulator of G protein signaling 14 (RGS14. We also found that aggrecan immunoreactivity was more evident in the anterior sections of the CA2 area than the posterior sections, which suggests that the function of CA2 PNNs varies along the anterior-posterior axis.

  14. PGC-1α accelerates cytosolic Ca2+ clearance without disturbing Ca2+ homeostasis in cardiac myocytes

    International Nuclear Information System (INIS)

    Chen, Min; Wang, Yanru; Qu, Aijuan

    2010-01-01

    Energy metabolism and Ca 2+ handling serve critical roles in cardiac physiology and pathophysiology. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is a multi-functional coactivator that is involved in the regulation of cardiac mitochondrial functional capacity and cellular energy metabolism. However, the regulation of PGC-1α in cardiac Ca 2+ signaling has not been fully elucidated. To address this issue, we combined confocal line-scan imaging with off-line imaging processing to characterize calcium signaling in cultured adult rat ventricular myocytes expressing PGC-1α via adenoviral transduction. Our data shows that overexpressing PGC-1α improved myocyte contractility without increasing the amplitude of Ca 2+ transients, suggesting that myofilament sensitivity to Ca 2+ increased. Interestingly, the decay kinetics of global Ca 2+ transients and Ca 2+ waves accelerated in PGC-1α-expressing cells, but the decay rate of caffeine-elicited Ca 2+ transients showed no significant change. This suggests that sarcoplasmic reticulum (SR) Ca 2+ -ATPase (SERCA2a), but not Na + /Ca 2+ exchange (NCX) contribute to PGC-1α-induced cytosolic Ca 2+ clearance. Furthermore, PGC-1α induced the expression of SERCA2a in cultured cardiac myocytes. Importantly, overexpressing PGC-1α did not disturb cardiac Ca 2+ homeostasis, because SR Ca 2+ load and the propensity for Ca 2+ waves remained unchanged. These data suggest that PGC-1α can ameliorate cardiac Ca 2+ cycling and improve cardiac work output in response to physiological stress. Unraveling the PGC-1α-calcium handing pathway sheds new light on the role of PGC-1α in the therapy of cardiac diseases.

  15. Osciladores Caóticos implementados en Microcontrolador PIC18F

    Directory of Open Access Journals (Sweden)

    R. Chiu

    2014-01-01

    Full Text Available Introducción: Recientemente, los sistemas caóticos han llamado la atención de la comunidad científica internacional, debido a sus potenciales aplicaciones en varias ramas de la ciencia e ingeniería. Se han propuesto muchos trabajos con el fin de resolver algunos problemas interesantes, como la determinación de daños estructurales en los materiales o en sistemas de comunicaciones seguras. Sin embargo, la mayoría de estos trabajos se enfocan en sistemas caóticos en tiempo continuo, mientras que en muchos casos, es deseable que estos sistemas estén en el modo de tiempo discreto y puedan ser utilizados en tiempo real. Método: El presente trabajo propone la implementación experimental de tres osciladores caóticos discretizados en un microcontrolador simple. Los osciladores caóticos a implementar son muy conocidos y muy utilizados para ejemplificar posibles soluciones a diversos problemas: los osciladores de Lorenz, Rössler y Chen. Para lo cual, se utilizan tan solo un microcontrolador de bajo costo, unos cuantos resistores y un algoritmo de computación sencillo. Resultados: Se obtiene un sistema embebido de bajo costo y sencillo para implementar osciladores caóticos discretizados. Discusión o Conclusión: Se demuestra que los osciladores caóticos de Lorenz, Rössler y Chen pueden implementarse en cualquier microcontrolador de arquitectura basada en palabras de 18 bits o más. Además, se observa que el algoritmo propuesto se pude migrar de un oscilador a otro con solo sustituir el sistema caótico de ecuaciones.

  16. O território do morango no Vale do Caí/RS : análise pela perspectiva dos sistemas agroalimentares localizados

    OpenAIRE

    Suzimary Specht

    2009-01-01

    No intuito de entender como o processo produtivo do morango vem gerando um território, objetiva-se nesta pesquisa averiguar, como as abordagens do Território e dos Sistemas Agroalimentares Localizados contribuem para a interpretação e análise das relações que ocorrem no Território do Morango, no Vale do Caí. Neste sentido é importante observar, tendo por referência os estudos sobre a abordagem do Território, como as relações de poder são manifestadas, independente da escala, gerando assimetri...

  17. La enseñanza de las matemáticas: El cuento como recurso

    OpenAIRE

    Herrero Infestas, Ana Isabel

    2012-01-01

    El presente trabajo recoge los aspectos más relevantes relacionados con la temática elegida, las matemáticas y los cuentos, así como la fundamentación teórica y los antecedentes de la misma. Además, se concreta con una propuesta de intervención para las aulas de Educación Infantil (para el segundo ciclo de 3–6 años) y se vincula con las competencias propias del Título de Grado anteriormente mencionado. Este documento ha sido estructurado en cuatro capítulos y dos anexos. En el primer ca...

  18. Evaluation of Serum CEA, CA19-9, CA72-4, CA125 and Ferritin as Diagnostic Markers and Factors of Clinical Parameters for Colorectal Cancer.

    Science.gov (United States)

    Gao, Yanfeng; Wang, Jinping; Zhou, Yue; Sheng, Sen; Qian, Steven Y; Huo, Xiongwei

    2018-02-09

    Blood-based protein biomarkers have recently shown as simpler diagnostic modalities for colorectal cancer, while their association with clinical pathological characteristics is largely unknown. In this study, we not only examined the sensitivity and reliability of single/multiple serum markers for diagnosis, but also assessed their connection with pathological parameters from a total of 279 colorectal cancer patients. Our study shown that glycoprotein carcinoembryonic antigen (CEA) owns the highest sensitivity among single marker in the order of CEA > cancer antigen 72-4 (CA72-4) > cancer antigen 19-9 9 (CA19-9) > ferritin > cancer antigen 125 (CA125), while the most sensitive combined-markers for two to five were: CEA + CA72-4; CEA + CA72-4 + CA125; CEA + CA19-9 + CA72-4 + CA125; and CEA + CA19-9 + CA72-4 + CA125 + ferritin, respectively. We also demonstrated that patients who had positive preoperative serum CEA, CA19-9, or CA72-4 were more likely with lymph node invasion, positive CA125 were prone to have vascular invasion, and positive CEA or CA125 were correlated with perineural invasion. In addition, positive CA19-9, CA72-4, or CA125 was associated with poorly differentiated tumor, while CEA, CA19-9, CA72-4, CA125 levels were positively correlated with pathological tumor-node-metastasis stages. We here conclude that combined serum markers can be used to not only diagnose colorectal cancer, but also appraise the tumor status for guiding treatment, evaluation of curative effect, and prognosis of patients.

  19. Como nasceu e como morreu o "marxismo ocidental" How the "Occidental Marxism" was born and died

    Directory of Open Access Journals (Sweden)

    Domenico Losurdo

    2011-04-01

    Full Text Available Por muito tempo o “marxismo ocidental” celebrou a sua superioridade em relação ao marxismo dos países que se remetiam ao socialismo e que estavam todos situados no Oriente. Em decorrência dessa atitude arrogante, o marxismo ocidental nunca se empenhou seriamente em repensar a teoria de Marx à luz de um balanço histórico concreto: qual era o papel do Estado e da nação nesses países e no “campo socialista”? Como promover a democracia e os direitos humanos e como estimular o desenvolvimento das forças produtivas e o bem-estar das massas numa situação caracterizada pelo bloqueio capitalista? Ao invés de pôr-se essas questões difíceis, o marxismo ocidental preferiu abandonar-se à cômoda atitude autoconsolatória de quem cultiva em particular as suas utopias e rejeita, como uma contaminação, o contato com a realidade e a reflexão sobre a realidade. Disso derivou uma progressiva capitulação à ideologia dominante. Por fim, a autocelebração do marxismo ocidental desembocou na sua autodissolução. Palavras-chave: Marxismo ocidental. Campo socialista. Falta de balanço histórico. Autodissolução. For a long time the “occidental Marxism” celebrated its superiority over the Marxism established in countries located in the Orient, to where the socialism was related. Due to this arrogante attitude, the occidental Marxism has never endeavored to rethink Marx’s theory upon a concrete historical summary: what was the role of the State and Nation in these countries and in the “socialist field”? How to promote the democracy and the human rights and how to estimulate the development of the productive forces and people’s welfare within a situation featured by the capitalist interdiction? Instead of opposing to those difficult questions, the occidental Marxism preferred to remain at a comfortable and self-consolating attitude, cultivating their particular utopias and rejecting, as a contamination, the contact to and

  20. Regulated release of Ca2+ from respiring mitochondria by Ca2+/2H+ antiport.

    Science.gov (United States)

    Fiskum, G; Lehninger, A L

    1979-07-25

    Simultaneous measurements of oxygen consumption and transmembrane transport of Ca2+, H+, and phosphate show that the efflux of Ca2+ from respiring tightly coupled rat liver mitochondria takes place by an electroneutral Ca2+/2H+ antiport process that is ruthenium red-insensitive and that is regulated by the oxidation-reduction state of the mitochondrial pyridine nucleotides. When mitochondrial pyridine nucleotides are kept in a reduced steady state, the efflux of Ca2+ is inhibited; when they are in an oxidized state, Ca2+ efflux is activated. These processes were demonstrated by allowing phosphate-depleted mitochondria respiring on succinate in the presence of rotenone to take up Ca2+ from the medium. Upon subsequent addition of ruthenium red to block Ca2+ transport via the electrophoretic influx pathway, and acetoacetate, to bring mitochondrial pyridine nucleotides into the oxidized state, Ca2+ efflux and H+ influx ensued. The observed H+ influx/Ca2+ efflux ratio was close to the value 2.0 predicted for the operation of an electrically neutral Ca2+/2H+ antiport process.

  1. Reduced endogenous Ca2+ buffering speeds active zone Ca2+ signaling.

    Science.gov (United States)

    Delvendahl, Igor; Jablonski, Lukasz; Baade, Carolin; Matveev, Victor; Neher, Erwin; Hallermann, Stefan

    2015-06-09

    Fast synchronous neurotransmitter release at the presynaptic active zone is triggered by local Ca(2+) signals, which are confined in their spatiotemporal extent by endogenous Ca(2+) buffers. However, it remains elusive how rapid and reliable Ca(2+) signaling can be sustained during repetitive release. Here, we established quantitative two-photon Ca(2+) imaging in cerebellar mossy fiber boutons, which fire at exceptionally high rates. We show that endogenous fixed buffers have a surprisingly low Ca(2+)-binding ratio (∼ 15) and low affinity, whereas mobile buffers have high affinity. Experimentally constrained modeling revealed that the low endogenous buffering promotes fast clearance of Ca(2+) from the active zone during repetitive firing. Measuring Ca(2+) signals at different distances from active zones with ultra-high-resolution confirmed our model predictions. Our results lead to the concept that reduced Ca(2+) buffering enables fast active zone Ca(2+) signaling, suggesting that the strength of endogenous Ca(2+) buffering limits the rate of synchronous synaptic transmission.

  2. EnviroAtlas - Fresno, CA - Block Groups

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset is the base layer for the Fresno, CA EnviroAtlas area. The block groups are from the US Census Bureau and are included/excluded based on...

  3. La mundialización del Darwinismo como proceso y como texto

    Directory of Open Access Journals (Sweden)

    Olga Matilde Restrepo Forero

    2009-10-01

    Full Text Available El fenómeno de la difusión del Darwinismo ha sido ampliamente estudiado. No solo existe una “Industria de Darwin” que se ha ocupado de investigar cómo se produjo la obra de Darwin, sino que también existe una “Industria de la Difusión del Darwinismo”, que investiga los procesos de recepción del Darwinismo en diversas partes del mundo. En el artículo se cuestiona la separación entre los estudios que examinan la producción del Origen de las especies y los que estudian su posterior difusión, considerados como procesos completamente independientes. Con base en unos pocos ejemplos, se muestra cómo Darwin fue produciendo y modificando su obra a partir de las contribuciones que fue recogiendo en diferentes partes del mundo y a partir de las respuestas que fue recibiendo a medida que su obra era comentada y discutida. Fianlmente se examina cómo al estudiar la mundialización del darwinismo surge el problema de cómo definir el fenómeno bajo estudio, si con una perspectiva normativa, que imponga un orden en la proliferación de sentidos que surge como consecuencia de la expansión, o con una perspectiva no-esencialista que más bien sitúe al darwinismo en relación con sus diferentes usos y apropiaciones locales.

  4. 7 CFR 15.3 - Discrimination prohibited.

    Science.gov (United States)

    2010-01-01

    ..., directly or through contractual or other arrangements, utilize criteria or methods of administration which... determining the site or location of facilities, an applicant or recipient may not make selections with the... participation in the Direct Distribution Program. (ii) Discrimination in the allocation of food to eligible...

  5. 50 CFR 15.3 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... thereof, but does not include domestic poultry, dead sport-hunted birds, dead museum specimens, dead... given time (e.g., endangered, threatened, vulnerable, non-threatened, or insufficiently known... species' population or habitat over time (e.g., increasing, decreasing, at equilibrium, insufficiently...

  6. 46 CFR 194.15-3 - Responsibility.

    Science.gov (United States)

    2010-10-01

    ... scientific party embarked may supervise the safety and operation of the chemical laboratory. (b) The laboratory supervisor shall: (1) Maintain the highest standards of safe working conditions. (2) Provide... GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS HANDLING, USE, AND...

  7. 47 CFR 15.3 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... within the protected area. (r) Peripheral device. An input/output unit of a system that feeds data into... programming, but not including: (1) A circuit board that contains only a microprocessor intended to operate...

  8. 6 CFR 15.3 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... physical or mental impairment that substantially limits one or more of the individual's major life... this definition: (1) Physical or mental impairment includes: (i) Any physiological disorder or... psychological disorder such as mental retardation, organic brain syndrome, emotional or mental illness, and...

  9. 10 CFR 15.3 - Communications.

    Science.gov (United States)

    2010-01-01

    ... Secretary of the Nuclear Regulatory Commission and sent either by mail to the U.S. Nuclear Regulatory..., by electronic submission, for example, via Electronic Information Exchange, or CD-ROM. Electronic... electronic submissions can be obtained by visiting the NRC's Web site at http://www.nrc.gov/site-help/e...

  10. Ischemic damage in hippocampal CA1 is dependent on glutamate release and intact innervation from CA3

    DEFF Research Database (Denmark)

    Benveniste, H; Jørgensen, M B; Sandberg, M

    1989-01-01

    The removal of glutamatergic afferents to CA1 by destruction of the CA3 region is known to protect CA1 pyramidal cells against 10 min of transient global ischemia. To investigate further the pathogenetic significance of glutamate, we measured the release of glutamate in intact and CA3-lesioned CA...

  11. YouthCaN 2001 / Sirje Janikson

    Index Scriptorium Estoniae

    Janikson, Sirje

    2001-01-01

    Aprillis 2001 toimus keskkonnateemaline õpilaskonverents YouthCaN 2001 Ameerika Loodusajaloo Muuseumis New Yorkìs. 35 seminarist ühe viis läbi Tartu Noorte Loodusmaja geoloogia ja keskkonnaringi esindus, tutvustati loodusmaja keskkonnaprojekte ja räägiti keskkonnaalaste veebilehtede koostamise kogemustest. YouthCaN (Youth Communicating and Networking) on rahvusvaheline noorte organisatsioon, mis vahendab kogemusi ja uusi ideid elukeskkonnast huvitatud noorte hulgas

  12. BiCaSrCuO superconductors

    International Nuclear Information System (INIS)

    Polvi, V.M.; Niemi, K.J.

    1989-01-01

    BiCaSrCuO and BiPbCaSrCuO powders have been synthesized. Different research methods (SEM,EDS,XRF,SRD,DTA) have been used to characterize the bulk specimen and wires. Resistance and current density measured as a function of temperature are reported. The ceramic products contained several phases. Lead containing specimen gave the best results and the synthesis was easily reproducible

  13. El Derecho Agrario como derecho para la paz

    Directory of Open Access Journals (Sweden)

    Ricardo Zeledón Zeledón

    2015-01-01

    Full Text Available Contenido: El Derecho agrario surgido de la paz y para la consolidación de la paz, como fuente e instrumento para su cumplimiento. La visión de Carrozza como conjunto de reglas destinadas al fin de la paz, y la equidad. Explicación de un Derecho agrario vinculado a la paz por su origen en los Derechos Humanos Económicos y Sociales. Evolución del Derecho Agrario en los Derechos Humanos de la tercera generación (principalmente ambiente, desarrollo y paz, en las nuevas dimensiones del Derecho agrario del futuro. Derecho agrario como derecho para la paz y el respeto de los derechos humanos. Desarrollo sostenible y agricultura del futuro. La nueva orientación de los institutos del derecho agrario como instrumentos de paz, dirigidos a cumplir los fines de la justicia social, el desarrollo económico y el equilibrio ambiental. Desarrollo como respuesta a los problemas del ambiente, alimentario, de la pobreza, indígena y de la mujer rural. El rol de la justicia agraria y ambiental como derecho para la paz. El derecho agrario, disciplina forjada en una concepción iushumanista, acorde con los derechos humanos y la paz. El derecho agrario como derecho para la paz.

  14. Francis Bacon sob o olhar de Gilles Deleuze: a imagem como intensidade

    Directory of Open Access Journals (Sweden)

    Osvaldo Fontes Filho

    2007-12-01

    Full Text Available O ensaio de Gilles Deleuze La logique de la sensation é texto que se detém principalmente na prática e na eficácia da imagem. A pintura de Francis Bacon é ali tomada como paradigma de modernidade ao investir contra os clichês expressivos e ao produzir imagem junto à brutalidade dos fatos, como um contra-efeito do narrativo. Em uma obra que conjura todo modelo a representar, toda história a contar, “alguma coisa se passa”, explica Deleuze, “que define o funcionamento da pintura”. Algo se passa, tem lugar: o acontecimento de uma catástrofe e de uma histeria no ato de pintura que acomete a Figura de modo a transmitir uma potencial violência de reação e de expressão. O “Bacon” de Deleuze apresenta a realidade vivida em uma nova e não-convencional ordem de sensação. Neste artigo, são comentados os modos como o filósofo interpreta os atos físicos da pintura de Bacon — marcas aleatórias, varredura da massa pictural, escansão das superfícies —, procedimentos que introduzem no mundo visual da figuração a variedade caótica dos fatos e sentidos. Mostra-se como as faces e as figuras contorcidas, distorcidas, escorchadas de Bacon recebem uma voz conceitual complementar no texto de Deleuze. Consequentemente, focaliza-se a disposição de alguns conceitos do filósofo: diagrama, Figura, diferença, espaço háptico. Locados no espaço afetivo ou na “lógica da sensação” da pintura baconiana, esses conceitos atribuem legitimidade ao entrelaçamento e à co-implicação entre arte e filosofia. Uma última observação dá conta do fato de a prática da imagem em Bacon, apresentada por Deleuze no palco de uma modernidade particularmente solapada por um “dilúvio anestésico de imagens reprimindo a possibilidade de pensar”, evidenciar para o filósofo os rumos necessariamente sinuosos, “reptilíneos”, do pensamento moderno. Tanto o conceito como a forma criam por catástrofe, por conflagração, por varia

  15. Study on the isospin equilibration phenomenon in nuclear reactions 40Ca + 40Ca , 40Ca + 46Ti , 40Ca + 48Ca , 48Ca + 48Ca at 25 MeV/nucleon by using the CHIMERA multidetector

    Science.gov (United States)

    Martorana, N. S.; Auditore, L.; Berceanu, I.; Cardella, G.; Chatterjee, M. B.; De Luca, S.; De Filippo, E.; Dell'Aquila, D.; Gnoffo, B.; Lanzalone, G.; Lombardo, I.; Maiolino, C.; Norella, S.; Pagano, A.; Pagano, E. V.; Papa, M.; Pirrone, S.; Politi, G.; Porto, F.; Quattrocchi, L.; Rizzo, F.; Russotto, P.; Trifirò, A.; Trimarchi, M.; Verde, G.; Vigilante, M.

    2017-11-01

    We report on the results obtained by studying nuclear reactions between isotopes of Ca and Ti at 25 MeV/nucleon. We used the multidetector CHIMERA to detect charged reaction products. In particular, we studied two main effects: the isospin diffusion and the isospin drift. In order to study these processes we performed a moving-source analysis on kinetic energy spectra of the isobar nuclei ^{3H} and ^{3He} . This method allows to isolate the emission from the typical sources produced in reactions at Fermi energy: projectile like fragment (PLF), target like fragment (TLF), and mid-velocity (MV) emission. The obtained results are compared to previous experimental investigations and to simulations obtained with CoMD-II model.

  16. La Seguridad ciudadana como función del Estado

    OpenAIRE

    Ridaura Martínez, María Josefa

    2014-01-01

    Este trabajo se centra en uno de los temas medulares de la organización del Estado como es la garantía de la seguridad, y tiene como objeto reivindicar, al calor la reciente sacudida legislativa en materia, la función de la Seguridad ciudadana como una función pública a desarrollar por las Fuerzas y Cuerpos de Seguridad; en tanto que exigencia constitucional, presupuesto de la salvaguarda de los derechos fundamentales y de las libertades públicas.

  17. El anisakis y sus enfermedades como enfermedad profesional

    OpenAIRE

    Vicente Pardo, José Manuel

    2016-01-01

    El anisakis es un parásito complejo de los animales marinos. El hombre no es el hospedador adecuado, ya que en él la larva L3 no puede completar su ciclo vital, siendo por tanto un hospedador accidental u ocasional, que se interpone en el ciclo vital del nemátodo, y al que el anisakis le puede causar tanto la parasitación como la alergia, cuando ingiere pescado o cefalópodos crudos o poco cocinados: tales como sushi, sashimi, ceviche gravlax noruego, lomi-lomi hawaiano, así como pescados en e...

  18. Present trophic conditions of the Como and Lecco basins of lake Como; Attuali condizioni trofiche dei bacini di Como e Lecco del Lario

    Energy Technology Data Exchange (ETDEWEB)

    Mosello, R.; Brizzio, M.C. [Consiglio Nazionale delle Ricerche, Verbania (Italy). Ist. Italiano di Idrobiologia; Garibaldi, L. [Milan Univ. La Bicocca, Milan (Italy). Dipt. di Scienze dell' Ambiente; Buzzi, P. [Azienda Sanitaria Locale, Lecco (Italy). Unita' Operativa Fisica e Tutela Ambiente; Colzani, L.; Pizzotti, E. [Azienda Sanitaria Locale, Como (Italy). Unita' Operativa Chimica; Mocellin, D. [Azienda Sanitaria Locale, Sondrio (Italy). Unita' Operativa Chimica

    1999-12-01

    Monthly measurements of temperature, water chemistry and phytoplankton performed from september 1997 to August 1998 in lake basins close the towns of Como and Lecco (Italy) are presented and discussed. Chemical variables show a high trophic level in both stations, more pronounced in the Como station due to unfavourable hydrological conditions and to urban and industrial sources of pollution, which show the predominance of Oscillatoria rubescens. [Italian] Il presente lavoro riporta i risultati di un'indagine condotta con campionamenti mensili dal settembre 1997 all'agosto 1998 nei bacini di Como e Lecco. Le variabili chimiche analizzate evidenziano, per entrambe le stazioni considerate, un elevato livello di trofia piu' pronunciato nella stazione di Come a causa di sfavorevoli condizioni idrologiche e per la presenza di sorgenti di inquinamento urbano e industriale, confermato dalla predominanza di Oscillatoria rubescens.

  19. Ca(2+-dependent regulation of the Ca(2+ concentration in the myometrium mitochondria. II. Ca(2+ effects on mitochondria membranes polarization and [Ca(2+](m

    Directory of Open Access Journals (Sweden)

    L. G. Babich

    2017-06-01

    Full Text Available It is known that Ca2+ accumulation in the mitochondria undergoes complex regulation by Ca2+ itself. But the mechanisms of such regulation are still discussed. In this paper we have shown that Ca ions directly or indirectly regulate the level of myometrium mitochondria membranes polarization. The additions of 100 µM Ca2+ were accompanied by depolarization of the mitochondria membranes. The following experiments were designed to study the impact of Ca2+ on the myometrium mitochondria [Ca2+]m. Isolated myometrium mitochondria were preincubated without or with 10 μM Са2+ followed by 100 μM Са2+ addition. Experiments were conducted in three mediums: without ATP and Mg2+ (0-medium, in the presence of 3 mM Mg2+ (Mg-medium and 3 mM Mg2+ + 3 mM ATP (Mg,ATP-medium. It was shown that the effects of 10 μM Са2+ addition were different in different mediums, namely in 0- and Mg-medium the [Ca2+]m values increased, whereas in Mg,ATP-medium statistically reliable changes were not registered. Preincubation of mitochondria with 10 μM Са2+ did not affect the [Ca2+]m value after the addition of 100 μM Са2+. The [Ca2+]m values after 100 μM Са2+ addition were the same in 0- and Mg,ATP-mediums and somewhat lower in Mg-medium. Preliminary incubation of mitochondria with 10 μM Са2+ in 0- and Mg-mediums reduced changes of Fluo 4 normalized fluorescence values that were induced by 100 μM Са2+ additions, but in Mg,ATP-medium such differences were not recorded. It is concluded that Са2+ exchange in myometrium mitochondria is regulated by the concentration of Ca ions as in the external medium, so in the matrix of mitochondria. The medium composition had a significant impact on the [Са2+]m values in the absence of exogenous cation. It is suggested that light increase of [Са2+]m before the addition of 100 μM Са2+ may have a positive effect on the functional activity of the mitochondria.

  20. Influence of ER leak on resting cytoplasmic Ca2+ and receptor-mediated Ca2+ signalling in human macrophage.

    Science.gov (United States)

    Layhadi, Janice A; Fountain, Samuel J

    2017-06-03

    Mechanisms controlling endoplasmic reticulum (ER) Ca 2+ homeostasis are important regulators of resting cytoplasmic Ca 2+ concentration ([Ca 2+ ] cyto ) and receptor-mediated Ca 2+ signalling. Here we investigate channels responsible for ER Ca 2+ leak in THP-1 macrophage and human primary macrophage. In the absence of extracellular Ca 2+ we employ ionomycin action at the plasma membrane to stimulate ER Ca 2+ leak. Under these conditions ionomycin elevates [Ca 2+ ] cyto revealing a Ca 2+ leak response which is abolished by thapsigargin. IP 3 receptors (Xestospongin C, 2-APB), ryanodine receptors (dantrolene), and translocon (anisomycin) inhibition facilitated ER Ca 2+ leak in model macrophage, with translocon inhibition also reducing resting [Ca 2+ ] cyto . In primary macrophage, translocon inhibition blocks Ca 2+ leak but does not influence resting [Ca 2+ ] cyto . We identify a role for translocon-mediated ER Ca 2+ leak in receptor-mediated Ca 2+ signalling in both model and primary human macrophage, whereby the Ca 2+ response to ADP (P2Y receptor agonist) is augmented following anisomycin treatment. In conclusion, we demonstrate a role of ER Ca 2+ leak via the translocon in controlling resting cytoplasmic Ca 2+ in model macrophage and receptor-mediated Ca 2+ signalling in model macrophage and primary macrophage. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. El trabajo de campo como proceso. La "etnografía colaborativa" como perspectiva analítica

    Directory of Open Access Journals (Sweden)

    Leticia Katzer

    2011-10-01

    Full Text Available El presente artículo contiene una serie de reflexiones elaboradas al poner en diálogo experiencias de campo en el marco de investigaciones individuales; una, con indígenas adscriptos como Huarpes, en el noreste de la provincia de Mendoza; la otra, con indígenas adscriptos como Qom. Éstas reflexiones intentan contribuir a desnaturalizar y visibilizar la complejidad de los contextos de interacción, considerando que abarcan distintas dimensiones y aspectos —tales como posición de los interlocutores en la estructura social, expectativas individuales, experiencias y relaciones previas de los sujetos, y recursos materiales y simbólicos en intermediación—, enfatizando así el carácter situacional y dinámico de esas relaciones de interlocución.A la luz de los actuales debates de la crítica cultural y en un intento por contribuir a los estudios de la Etnografía Colaborativa, el objetivo de este artículo es exponer y describir comparativamente lo que entendemos como performances de campo, situando como objeto de análisis la experiencia etnográfica en sí misma. Entendiendo el trabajo etnográfico como proceso y texto, identificamos tres grandes nudos críticos, reunidos en tres escenas etnográficas, que analizamos como una red multisituada de mediaciones e interrelaciones.

  2. Prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma

    Science.gov (United States)

    Wang, Wei; Chen, Xiao-Long; Zhao, Shen-Yu; Xu, Yu-Hui; Zhang, Wei-Han; Liu, Kai; Chen, Xin-Zu; Yang, Kun; Zhang, Bo; Chen, Zhi-Xin; Chen, Jia-Ping; Zhou, Zong-Guang; Hu, Jian-Kun

    2016-01-01

    The prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma (GC) has been widely reported and is still under debate. Here, we evaluated the prognostic significance of preoperative serum CA125, CA19-9 and CEA in patients with GC. 1692 patients with GC who underwent gastrectomy were divided into the training (from January 2005 to December 2011, n = 1024) and the validation (from January 2012 to December 2013, n = 668) cohorts. Positive groups of CA125 (> 13.72 U/ml), CA19-9 (> 23.36 U/ml) and CEA (> 4.28 ng/ml) were significantly associated with more advanced clinicopathological traits and worse outcomes than that of negative groups (all P tumor size (P tumor markers (NPTM) were more accurate in prognostic prediction than TNM stage alone. Our findings suggested that elevated preoperative serum CA125, CA19-9 and CEA were associated with more advanced clinicopathological traits and less favorable outcomes. In addition, CA125 as an independent prognostic factor should be further investigated. Nomogram based on NPTM could accurately predict the prognosis of GC patients. PMID:27097114

  3. Electronic structures and magnetism of CaFeAsH and CaFeAsF

    International Nuclear Information System (INIS)

    Wang Guangtao; Shi Xianbiao; Liu Haipeng; Liu Qingbo

    2015-01-01

    We studied the electronic structures, magnetism, and Fermi surface (FS) nesting of CaFeAsH and CaFeAsF by first-principles calculations. In the nonmagnetic (NM) states, we found strong FS nesting, which induces magnetic instability and a spin density wave (SDW). Our calculations indicate that the ground state of CaFeAsH and CaFeAsF is the stripe antiferromagnetic state. The calculated bare susceptibility χ 0 (q) peaked at the M-point and was clearly suppressed and became slightly incommensurate with both electron doping and hole doping for both materials. (author)

  4. Study of 40Ca-40Ca elastic scattering at intermediate energy

    International Nuclear Information System (INIS)

    Kumar, Ashok; Srivastava, B.B.

    1980-01-01

    The differential cross sections for 40 Ca- 40 Ca elastic scattering have been calculated at laboratory incident energy of 240 MeV using a sharp cut off of the partial waves below a critical angular momentum, 1sub(c)' to account for absorption. The effective 40 Ca- 40 Ca potential is taken to be the sum of a real nuclear potential and the Coulomb potential. The calculated differential cross sections which are in fair agreement with the experimental data are presented and discussed. (author)

  5. Impact parameter determination for 40Ca + 40Ca reactions using a neural network

    International Nuclear Information System (INIS)

    Haddad, F.; Hagel, K.; Li, J.; Mdeiwayeh, N.; Natowitz, J.B.; Wada, R.; Xiao, B.; David, C.; Freslier, M.; Aichelin, J.

    1995-01-01

    A neural network is used for the impact parameter determination in 40 Ca + 40 Ca reactions at energies between 35 and 70 AMeV. A special attention is devoted to the effect of experimental constraints such as the detection efficiency. An overall improvement of the impact parameter determination of 25% is obtained with the neural network. The neural network technique is then used in the analysis of the Ca+Ca data at 35 AMeV and allows separation of three different class of events among the selected 'complete' events. (authors). 8 refs., 5 figs

  6. Mg/Ca of Continental Ostracode Shells

    Science.gov (United States)

    Ito, E.; Forester, R. M.; Marco-Barba, J.; Mezquita, F.

    2007-12-01

    Marine ionic chemistry is thought to remain constant. This, together with the belief that marine calcifiers partition Mg/Ca in a systematic manner as functions of temperature (and Mg/Ca) of water forms the basis of the Mg/Ca thermometer. In continental settings both of these assumptions are usually not true. Continental waters contain a wide variety of solutes in absolute and relative ion concentrations. Hence, waters with identical Mg/Ca may have very different concentrations of Mg and Ca and very different anions. Here we use two examples to focus on the effects of ion chemistry on Mg/Ca partitioning in continental ostracode shells and we ignore the complexities of solute evolution, which can change Mg/Ca over timescales of minutes to millennia. Palacios-Fest and Dettman (2001) conducted a monthly study of ,Cypridopsis vidua at El Yeso Lake in Sonora, Mexico. They established a relation between temperature and average shell Mg/Ca using regression analyses on averaged data. When their Mg/Ca-temperature relation is applied to monthly ,C. vidua data from Page Pond near Cleveland, Ohio, water temperatures of -8 to -1°C are obtained. The observed Mg/Ca ranges for El Yeso Lake (0.31 to 0.46) and Page Pond (0.33 to 0.46) are similar, as are their specific conductivities (700 to 850μS for El Yeso Lake; 400 to 600μS for Page Pond). However, [Ca] is 140-260 mg/L for El Yeso, but only 70-90 mg/L for Page Pond. Page Pond data, in fact, shows a good temperature shell Mg/Ca relation for .C. vidua, but the relation is different from that at El Yeso. Hence, shell Mg/Ca is a multi-valued, family of curves function of temperature and Mg/Ca of water that depends on the [Mg] and [Ca] values in water and perhaps other factors. Our second example comes from sites near Valencia, Spain and involves shell data for ,Cyprideis torosa, an estuarine ostracode that is tolerant of a wide range of salinity and can live in continental waters as long as the carbonate alkalinity to Ca ratio is

  7. Physical conditions in CaFe interstellar clouds

    OpenAIRE

    Gnacinski, P.; Krogulec, M.

    2007-01-01

    Interstellar clouds that exhibit strong Ca I and Fe I lines were called CaFe clouds. The ionisation equilibrium equations were used to model the column densities of Ca II, Ca I, K I, Na I, Fe I and Ti II in CaFe clouds. The chemical composition of CaFe clouds is that of the Solar System and no depletion of elements onto dust grains is seen. The CaFe clouds have high electron densities n=1 cm^-3 that leads to high column densities of neutral Ca and Fe.

  8. Absolute Ca Isotopic Measurement Using an Improved Double Spike Technique

    Directory of Open Access Journals (Sweden)

    Jason Jiun-San Shen

    2009-01-01

    Full Text Available A new vector analytical method has been developed in order to obtain the true isotopic composition of the 42Ca-48Ca double spike. This is achieved by using two different sample-spike mixtures combined with the double spike and natural Ca data. Be cause the natural sample (two mixtures and the spike should all lie on a single mixing line, we are able to con strain the true isotopic composition of our double spike using this new approach. Once the isotopic composition of the Ca double spike is established, we are able to obtain the true Ca isotopic composition of the NIST Ca standard SRM915a, 40Ca/44Ca = 46.537 ± 2 (2sm, n = 55, 42Ca/44Ca = 0.31031 ± 1, 43Ca/44Ca = 0.06474 ± 1, and 48Ca/44Ca = 0.08956 ± 1. De spite an off set of 1.3% in 40Ca/44Ca between our result and the previously re ported value (Russell et al. 1978, our data indicate an off set of 1.89__in 40Ca/44Ca between SRM915a and seawater, entirely consistent with the published results.

  9. La reforma agraria como factor del desarrollo regional

    Directory of Open Access Journals (Sweden)

    José Ambrósio Ferreira Neto

    2017-01-01

    Full Text Available Este trabajo debate la reforma agraria brasilera como instrumento de desarrollo regional, discutiendo la política actual de asentamientos rurales y su importancia en los procesos de interacción con las dinámicas locales y regionales, investigando las transformaciones que esos proyectos pueden provocar en los municipios donde están inmersos. El trabajo toma como punto central de discusión los argumentos de Polanyi sobre los factores de producción, tierra, capital y trabajo, y de Amartya Sen sobre libertad como factor de desarrollo. La discusión emprendida defiende la reforma agraria como forma de conceder oportunidades y una condición de agentes a sus beneficiarios. Argumentamos que el acceso a la tierra, y a los medios de producción, garantiza al trabajador el control sobre su fuerza de trabajo.

  10. Quests em World Of Warcraft como estrutura narrativa seriada

    Directory of Open Access Journals (Sweden)

    Jônatas Kerr de Oliveira

    2010-10-01

    Full Text Available Assumindo que as quests em World of Warcraft funcionam como uma estrutura narrativa dentro do jogo, busca-se verificar se esta estrutura apresenta características que possam caracterizá-la como uma narrativa seriada. Para tal, é feita uma análise das principais características da narrativa seriada televisiva, assim como da estrutura de quests, para verificar a viabilidade de tal aproximação. Sendo a estrutura narrativa de quests em MMORPGs uma estrutura narrativa seriada, abre-se um grande leque de possibilidades, tanto para as análises teóricas dos videogames, utilizando o ferramental adaptado, como para os game designers utilizarem este referencial para acrescer detalhes aos mundos ficcionais criados.

  11. La importancia del patrocinio deportivo : el surf como última tendencia

    OpenAIRE

    Lvov a Zemlianskaia,Victoria

    2015-01-01

    Se pretende dar a conocer el motivo del constante incremento del patrocinio deportivo, concretamente en el mundo del surf. Esta estrategia de marketing es empleada por muchas marcas como clave del éxito en la diferenciación

  12. Como Podar Arboles (Spanish Version), How to Prune Trees

    Science.gov (United States)

    Maureen McDonough; Russell; Lisa Burban; Lee Nancarrow; United States Department of Agriculture, Forest Service, Northeastern Area, State and Private Forestry

    2004-01-01

    Introduccion, El proposito de la poda es tener plantas fuertes, sanas y atractivas. Esta meta se puede alcanzar sabiendo como, cuando y por que podar, y siguiendo unos cuantos principios muy sencillos.

  13. UNIVERSIDADE CORPORATIVA COMO ALAVANCA DA VANTAGEM COMPETITIVA

    Directory of Open Access Journals (Sweden)

    Maria Elisabeth Pereira Kraemer

    2004-05-01

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    RESUMO

    A educação formal para o trabalho, em nível superior, começa a enfrentar uma concorrência inusitada: as universidades corporativas, surgidas das experiências de programas de treinamento e desenvolvimento profissionais corporativos e da constatação de que a universidade não prepara adequadamente para o trabalho. O conceito de universidade corporativa surgiu nos EUA, em 1995, quando a General Eletric criou a Cotronville. Mas foi só a partir da década de 80 que se assistiu a um aumento considerável destes novos espaços de formação. Outro componente que contribuiu para o rápido crescimento das universidades corporativas é a necessidade de contínua aprendizagem, como conseqüência das vertiginosas mudanças no mundo do trabalho, em razão dos avanços tecnológicos permanentes e do processo de globalização da economia. As universidades corporativas surgem como solução para o alinhamento das iniciativas de treinamento com a estratégia da organização e de criação de vantagem competitiva, por meio de aprendizado permanente.

    Palavras-chave: avanços tecnológicos, universidade corporativa, vantagem competitiva

     

    ABSTRACT

    The formal education for the work in superior level

  14. LOS ACTORES DEL ESCENARIO PEDAGÓGICO COMO COMPONENTE DEL MODELO PEDAGÓGICO PARA INDISCIPLINAR EL DERECHO COMO CIENCIA

    Directory of Open Access Journals (Sweden)

    Jorge Eduardo Vásquez Santamaría

    2011-01-01

    Full Text Available Resultado del escenario pedagógico como plataforma inicial problematizadora a partir de la cual se identifican y describen fundamentos orientadores tradicionales y no tradicionales que permitan reevaluar el Derecho para acreditarlo como ciencia social, se exponen los resultados obtenidos en el trabajo de campo adelantado con abogados docentes y estudiantes de Derecho como sus actores pedagógicos, quienes representan los elementos “Quién” y “A quién” del modelo pedagógico, en este caso primordialmente tradicionalista, imperante en los currículos de los programas de Derecho deColombia.

  15. El antropomorfismo como generador de amor a la marca

    OpenAIRE

    Peláez Muñoz, Jenny

    2017-01-01

    Tradicionalmente el concepto de amor se ha considerado como un sentimiento que pertenece exclusivamente al ámbito de los seres humanos y que no puede ser aplicado a cosas ordinarias como un producto o una marca. Sin embargo, esta idea ha sido cuestionada por la literatura de marketing dado que diferentes estudios reconocen que los individuos pueden sentir amor hacia ideas, actividades, aficiones, animales y objetos (ver Fournier, 1998; Ahuvia et al., 2009). Los estudios académicos sobre marca...

  16. Pesquisa como instrumento da prática

    Directory of Open Access Journals (Sweden)

    Maura Maria Guimarães de Almeida

    1995-06-01

    Full Text Available O trabalho aborda a utilização da pesquisa como instrumento da prática profissional da enfermaria na área de assistência, administração e ensino. Situa a ciência como processo. Ressalta a responsabilidade da enfermeira na produção da conhecimento científico. Destaca os fatores que dificultam e facilitam a pesquisa, além dos aspectos éticos envolvidos.

  17. El buen entrenador como experto adaptativo que lidera al grupo

    Directory of Open Access Journals (Sweden)

    Sergio Jim\\u00E9nez S\\u00E1iz

    2010-01-01

    expertos en baloncesto, siguiendo los criterios de la literatura específica. Los resultados reflejan que los entrenadores destacan la capacidad de adaptación al contexto que les rodea, como algo prioritario para alcanzar el éxito como entrenadores. Los entrevistados subrayan que no abandonan su modelo de entrenamiento cuando cambian de contexto, sino que lo adaptan a una situación distinta.

  18. LAS CIUDADES COMO TERRITORIO DE LA EDUCACIÓN INTEGRAL

    Directory of Open Access Journals (Sweden)

    Maria Silvia Serra

    2015-12-01

    Full Text Available RESUMEN: Habitar las ciudades es un proceso en el que se encuentran anudadas cuestiones materiales y simbólicas. Este lazo debe ser atendido y puesto en valor en términos históricos y culturales ya que forma parte de nuestro aprendizaje como sujetos urbanos. En este sentido, tal como afirma Andreas Huyssen (2002: 191 "...la ciudad funciona como un tipo de prisma" que permite "enfocar" una multiplicidad de temáticas que no están solo ligadas al urbanismo o a la arquitectura, sino también a experiencias culturales y construcciones simbólicas que articulan el hecho concreto de vivir en las ciudades. Es así que, siguiendo a este autor, podemos afirmar que la ciudad es un texto que puede ser leído como un verdadero espacio de signos. Una casa, un barrio, un edificio, los espacios públicos, las calles y veredas, los monumentos son reservorios de un tiempo y una memoria que requieren de una multiplicidad de lecturas para transformarse en escenarios de aprendizajes integradores. Cuestionar a la ciudad como territorio de la educación integral así como reconocer las cuestiones centrales que se ponen a prueba cuando esto se postula como una política pública son los objetivos principales del presente artículo, para lo cual proponemos un recorrido a partir de considerar conceptos nodales como los de educación integral y pedagogía urbana.

  19. Derivados de pirazol bivalentes como inhibidores de ingesta

    OpenAIRE

    Rodríguez de Fonseca, Fernando; Jagerovic, Nadine; Fernández Fernández, Cristina; Bermúdez-Silva, Francisco Javier; Goya, Pilar

    2011-01-01

    Derivados de pirazol bivalentes como inhibidores de ingesta. Nuevos derivados alquílicos y cicloalquílicos disustituidos por pirazol-3-carboxamidas, así como su procedimiento de obtención. Estos compuestos presentan propiedades, entre otras, para la inducción de saciedad y control de la ingesta, modulación de la grasa corporal y regulación del metabolismo lipídico.

  20. EL APRENDIZAJE ORGANIZACIONAL COMO FACILITADOR DE RELACIONES SOCIALES RESPONSABLES

    Directory of Open Access Journals (Sweden)

    Eliecer Mayorca Capataz

    2014-08-01

    Full Text Available La importancia que tienen las relaciones sociales y el aprendizaje en la vida del ser humano: ser social, ser de relaciones, un ser abierto que se define por las relaciones con los demás, se considera imprescindible, abordar el tema para favorecer el desarrollo integral de la personas. Ello supone que, la vida para su permanente desarrollo implica en la persona, articular un entramado de relaciones, mediante la experiencia de aprendizaje y el reconocimiento de los valores fundamentales como el respeto por la humanidad, en un todo interrelacionado, en el que, de alguna forma, remite el actuar de las personas, a su racionalidad, a su espontaneidad, a la forma como se comunica y trabaja con los otros, a la manera constante de aprender, de buscar la calidad de vida, de amar su oficio como forma de influencia positiva, y establecer relaciones socialmente responsables. Para ello, se estableció como objetivo: realizar un análisis conceptual del aprendizaje organizacional como facilitador de las relaciones sociales responsables en la organización. Metodológicamente, el trabajo es de carácter documental y bibliográfico, soportadas en investigaciones previas; y como reflexión se estableció que el centro para aprender y relacionarse es el hombre.

  1. Indianización como proceso y como discurso en Chiapas, México

    Directory of Open Access Journals (Sweden)

    ALEJANDRO GARCÍA GUERRERO

    2002-01-01

    Full Text Available ESTE ENSAYO BUSCA COMPRENDER UN PROCESO SOCIAL EN EL QUE LOS indígenas mayas del centro de Chiapas, México, muestran su avance territorial, demográfico, laboral y político por medio del discurso de sus líderes. Se trata de un movimiento étnico que integra las dos dimensiones del proceso de globalización: la homogeneización y la heterogeneización cultural mundial. La perspectiva adoptada integra el análisis del discurso desde un punto de vista flexible y comprensivo de la producción cultural con el análisis del proceso de indianización regional como un sistema interétnico complejo, en el sentido melucciano de sistema. El objetivo principal es explicar cómo los líderes indígenas utilizan el discurso -para persuadir a sus huestes y a los otros- construyendo uno de identidad basado en un pasado significativo ordenado en y para el presente político.

  2. Factores de competitividad de la agroindustria de la caña de azúcar en México

    Directory of Open Access Journals (Sweden)

    Noé Aguilar Rivera

    2011-01-01

    Full Text Available La industria azucarera de México integra actividades agrícolas de crecimiento, cosecha y transporte de caña a la producción de azúcar estándar y refinada, con otros productos y subproductos. Para competir en una economía global, es importante establecer criterios de desempeño para reducir costos de producción en términos de competitividad técnica, productividad y eficiencia en aspectos como rendimientos, caña de azúcar y agroindustrial por hectárea y de fábrica. En este artículo se discuten algunos indicadores de competitividad económica y técnica de la industria de caña de azúcar mexicana, con metodologías de benchmarking y diamante de Porter. Los resultados mostraron que son numerosos los factores técnicos y económicos que limitan el crecimiento, debido a que la industria mexicana se ha mantenido no competitiva y requiere mejorar e innovar en la reducción de costos, sobre todo en materia prima, cosecha y transporte. También está la diversificación, con base en los subproductos, como residuos de cosecha, bagazo, melazas, lodo de filtros y vinazas; esto es de gran importancia como fuente renovable de energía y materias primas.

  3. The destiny of Ca(2+) released by mitochondria.

    Science.gov (United States)

    Takeuchi, Ayako; Kim, Bongju; Matsuoka, Satoshi

    2015-01-01

    Mitochondrial Ca(2+) is known to regulate diverse cellular functions, for example energy production and cell death, by modulating mitochondrial dehydrogenases, inducing production of reactive oxygen species, and opening mitochondrial permeability transition pores. In addition to the action of Ca(2+) within mitochondria, Ca(2+) released from mitochondria is also important in a variety of cellular functions. In the last 5 years, the molecules responsible for mitochondrial Ca(2+) dynamics have been identified: a mitochondrial Ca(2+) uniporter (MCU), a mitochondrial Na(+)-Ca(2+) exchanger (NCLX), and a candidate for a mitochondrial H(+)-Ca(2+) exchanger (Letm1). In this review, we focus on the mitochondrial Ca(2+) release system, and discuss its physiological and pathophysiological significance. Accumulating evidence suggests that the mitochondrial Ca(2+) release system is not only crucial in maintaining mitochondrial Ca(2+) homeostasis but also participates in the Ca(2+) crosstalk between mitochondria and the plasma membrane and between mitochondria and the endoplasmic/sarcoplasmic reticulum.

  4. Selectividad de caña de azúcar en bovinos

    Directory of Open Access Journals (Sweden)

    E. M. Aranda

    2009-01-01

    Full Text Available Se condujo este trabajo con el objetivo de conocer la aceptación del forraje de caña de azúcar integral en la dieta con base de pasto para bovinos adultos fistulados en rumen y duodeno estabulados; para ello, se ofreció pasto estrella africana (Cynodon plectostachyus y caña de azúcar (Saccharum officinarum mezclada con 1% de urea a voluntad, por separado. Se midió la composición de los alimentos, consumo de materia seca, pH ruminal y duodenal. Se utilizaron técnicas de la estadística descriptiva, como la media aritmética y error estándar. La proteína, paredes celulares y hemicelulosa fueron mayores para el pasto estrella. El consumo de MS fue de 46.6 y 38.1% para la caña de azúcar y el pasto, respectivamente; el pH ruminal tuvo valores de 7.3, disminuyendo a 6.7 a las 12 h.; y el pH de la digesta duodenal osciló de 3.7 a 4.7. Se concluye que hubo mayor aceptación por la caña de azúcar y el pH ruminal no indica valores que afecten la celulólisis ruminal.

  5. La prevención de caídas recurrentes en el paciente anciano

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    Miriam Bella Beorlegui

    Full Text Available RESUMEN Las caídas son “acontecimientos involuntarios que hacen perder el equilibrio y dar con el cuerpo en la tierra u otra superficie firme que lo detenga”. Las caídas recurrentes (presencia de dos o más caídas en un año constituyen un problema frecuente en centros residenciales, y predisponen a las personas mayores a sufrir incapacidad, dependencia y múltiples enfermedades. La aplicación de medidas de prevención puede disminuir notablemente su incidencia y, por tanto, sus consecuencias. El objetivo de este trabajo es identificar qué intervenciones de enfermería pueden ayudar a prevenir caídas recurrentes en las personas mayores institucionalizadas, y minimizar el impacto emocional que ocasionan estos episodios. Para ello, se desarrolla un caso clínico y, tras el análisis de la evidencia científica, se proponen intervenciones para evitar la recurrencia de un episodio de caída y sus consecuencias. El análisis de este caso se estructura en valoración de riesgo de caídas recurrentes e intervenciones de prevención de las mismas. Y, a su vez, cada apartado se divide en aspectos físicos y emocionales. La literatura especializada refleja que la valoración del riesgo de caídas es clave para implantar un plan de cuidados. Conocer los factores de riesgo intrínsecos y extrínsecos ayudará a los profesionales a diseñar intervenciones de prevención. Asimismo, se ha identificado el impacto emocional que producen las caídas en los pacientes y se proponen algunas intervenciones para aliviarlo. Este trabajo refuerza la importancia de realizar una adecuada valoración de enfermería a las personas mayores en riesgo de sufrir caídas recurrentes, a través de diferentes instrumentos para detectar las áreas específicas de intervención. Se concluye con la necesidad de protocolizar esta valoración, tanto física como emocional, para poder individualizarla posteriormente con cada paciente.

  6. Changes in the expression of serum markers CA242, CA199, CA125, CEA, TNF-α and TSGF after cryosurgery in pancreatic cancer patients.

    Science.gov (United States)

    Zhou, Gang; Niu, Lizhi; Chiu, David; He, Lihua; Xu, Kecheng

    2012-07-01

    The presence of serum tumor markers, carbohydrate antigen 242 (CA242), carbohydrate antigen 199 (CA199), carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), tumor-supplied group of factors (TSGF) and tumor necrosis factor-α (TNF-α), is closely associated with invasion and metastasis of many malignancies. The expression of these markers were measured in serum taken from 37 pancreatic cancer patients prior to treatment. Levels of CA242, CA199, CA125, CEA and TNF-α expression correlated with tumor size, clinical stage, tumor differentiation, lymph node and liver metastasis (P markers were significantly reduced compared with levels prior to cryosurgery (P 0.05). Thus, cryosurgery is more effective than chemotherapy for decreasing CA242, CA199, CA125, CEA, TSGF and TNF-α serum levels in these patients.

  7. Estilos parentais como fator de proteção ao consumo de tabaco entre adolescentes brasileiros

    Directory of Open Access Journals (Sweden)

    Cláudia S. Tondowski

    2015-12-01

    Full Text Available Resumo O objetivo foi analisar a associação entre o uso de tabaco (no mês e frequente com os estilos parentais e o comportamento de fumar dos pais, em uma amostra de estudantes do Ensino Médio. Foram avaliados 17.246 estudantes do Ensino Médio de escolas públicas e privadas das 27 capitais brasileiras. A prevalência do uso de tabaco na vida foi de 25,2%, 15,3% no ano, 8,6% no mês, e 3,2% para uso frequente. Em relação aos estilos parentais, 39,2% dos pais foram classificados como negligentes, 33,3% autoritativos, 15,6% como indulgentes e 11,9% autoritários. Comparados a estudantes com pais autoritativos, filhos de pais negligentes ou indulgentes tiveram maior chance de relatar o uso no último mês ou frequente de tabaco. Observou-se uma associação entre o estilo parental e uso de cigarros por estudantes do Ensino Médio. O estilo parental autoritativo foi associado à proteção ao uso de tabaco no mês e frequente entre os adolescentes.

  8. Ventral tegmental area disruption selectively affects CA1/CA2 but not CA3 place fields during a differential reward working memory task.

    Science.gov (United States)

    Martig, Adria K; Mizumori, Sheri J Y

    2011-02-01

    Hippocampus (HPC) receives dopaminergic (DA) projections from the ventral tegmental area (VTA) and substantia nigra. These inputs appear to provide a modulatory signal that influences HPC dependent behaviors and place fields. We examined how efferent projections from VTA to HPC influence spatial working memory and place fields when the reward context changes. CA1 and CA3 process environmental context changes differently and VTA preferentially innervates CA1. Given these anatomical data and electrophysiological evidence that implicate DA in reward processing, we predicted that CA1 place fields would respond more strongly to both VTA disruption and changes in the reward context than CA3 place fields. Rats (N = 9) were implanted with infusion cannula targeting VTA and recording tetrodes aimed at HPC. Then they were tested on a differential reward, win-shift working memory task. One recording session consisted of 5 baseline and 5 manipulation trials during which place cells in CA1/CA2 (N = 167) and CA3 (N = 94) were recorded. Prior to manipulation trials rats were infused with either baclofen or saline and then subjected to control or reward conditions during which the learned locations of large and small reward quantities were reversed. VTA disruption resulted in an increase in errors, and in CA1/CA2 place field reorganization. There were no changes in any measures of CA3 place field stability during VTA disruption. Reward manipulations did not affect performance or place field stability in CA1/CA2 or CA3; however, changes in the reward locations "rescued" performance and place field stability in CA1/CA2 when VTA activity was compromised, perhaps by trigging compensatory mechanisms. These data support the hypothesis that VTA contributes to spatial working memory performance perhaps by maintaining place field stability selectively in CA1/CA2. Copyright © 2009 Wiley-Liss, Inc.

  9. Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas

    DEFF Research Database (Denmark)

    Gustavsson, Natalia; Wei, Shun-Hui; Hoang, Dong Nhut

    2009-01-01

    Hormones such as glucagon are secreted by Ca(2+)-induced exocytosis of large dense-core vesicles, but the mechanisms involved have only been partially elucidated. Studies of pancreatic beta-cells secreting insulin revealed that synaptotagmin-7 alone is not sufficient to mediate Ca(2+)-dependent i...

  10. Capture reactions of 40Ca and 48Ca with targets of 197Au and 208Pb

    International Nuclear Information System (INIS)

    Stokstad, R.; Chan, Y.; Chavez, E.

    1988-03-01

    The reactions of 40 Ca and 48 Ca with targets of 197 Au and 208 Pb have been measured in the region from below the interaction barrier to about twice the barrier energy. The fission-like fragments were detected in a pair of position-sensitive, multi-wire proportional counters and were identified from measurements of position and time using two-body kinematics. In the region above the barrier the cross sections for capture are less than those given by the touching condition, indicating that an /open quotes/extra push/close quotes/ is required to induce capture. The observations for 40 Ca and 48 Ca show different fissilities for the onset of the extra push and indicate that charge equilibration may be an important factor governing capture reactions. Below the barrier the cross sections show an enhancement relative to the prediction for a one dimensional barrier. The enhancements are larger for 40 Ca than for 48 Ca (for both targets) and this is in qualitative agreement with predictions based on the coupling of the relative motion to low-lying collective states. Both above and below the barrier, we find that the change in the light partner, from 48 Ca to 40 Ca, has a larger effect on the cross sections than the change from 208 Pb to 197 Au, after correction for the change in the Coulomb barrier. 16 refs., 7 figs

  11. Intercellular Ca2+ Waves: Mechanisms and Function

    Science.gov (United States)

    Sanderson, Michael J.

    2012-01-01

    Intercellular calcium (Ca2+) waves (ICWs) represent the propagation of increases in intracellular Ca2+ through a syncytium of cells and appear to be a fundamental mechanism for coordinating multicellular responses. ICWs occur in a wide diversity of cells and have been extensively studied in vitro. More recent studies focus on ICWs in vivo. ICWs are triggered by a variety of stimuli and involve the release of Ca2+ from internal stores. The propagation of ICWs predominately involves cell communication with internal messengers moving via gap junctions or extracellular messengers mediating paracrine signaling. ICWs appear to be important in both normal physiology as well as pathophysiological processes in a variety of organs and tissues including brain, liver, retina, cochlea, and vascular tissue. We review here the mechanisms of initiation and propagation of ICWs, the key intra- and extracellular messengers (inositol 1,4,5-trisphosphate and ATP) mediating ICWs, and the proposed physiological functions of ICWs. PMID:22811430

  12. Fusion dynamics in 40Ca induced reactions

    International Nuclear Information System (INIS)

    Prasad, E.; Hinde, D.J.; Williams, E.

    2017-01-01

    Synthesis of superheavy elements (SHEs) and investigation of their properties are among the most challenging research topics in modern science. A non-compound nuclear process called quasi fission is partly responsible for the very low production cross sections of SHEs. The formation and survival probabilities of the compound nucleus (CN) strongly depend on the competition between fusion and quasi fission. A clear understanding of these processes and their dynamics is required to make reliable predictions of the best reactions to synthesise new SHEs. All elements beyond Nh are produced using hot fusion reactions and beams of 48 Ca were used in most of these experiments. In this context a series of fission measurements have been carried out at the Australian National University (ANU) using 40;48 Ca beams on various targets ranging from 142 Nd to 249 Cf. Some of the 40 Ca reactions will be discussed in this symposium

  13. Applicative Value of Serum CA19-9, CEA, CA125 and CA242 in Diagnosis and Prognosis for Patients with Pancreatic Cancer Treated by Concurrent Chemoradiotherapy.

    Science.gov (United States)

    Gu, Yu-Lei; Lan, Chao; Pei, Hui; Yang, Shuang-Ning; Liu, Yan-Fen; Xiao, Li-Li

    2015-01-01

    To evaluate the application value of serum CA19-9, CEA, CA125 and CA242 in diagnosis and prognosis of pancreatic cancer cases treated with concurrent chemotherapy. 52 patients with pancreatic cancer, 40 with benign pancreatic diseases and 40 healthy people were selected. The electrochemiluminescence immunoassay method was used for detecting levels of CA19-9, CEA and CA125, and a CanAg CA242 enzyme linked immunoassay kit for assessing the level of CA242. The Kaplan-Meier method was used for analyzing the prognostic factors of patients with pancreatic cancer. The Cox proportional hazard model was applied for analyzing the hazard ratio (HR) and 95% confidential interval (CI) for survival time of patients with pancreatic cancer. The levels of serum CA19-9, CEA, CA125 and CA242 in patients with pancreatic cancer were significantly higher than those in patients with benign pancreatic diseases and healthy people (PCEA. The specificity of CA242 is the highest, followed by CA125, CEA and CA19-9. The sensitivity and specificity of joint detection of serum CA19-9, CEA, CA125and CA242 were 90.4% and 93.8%, obviously higher than single detection of those markers in diagnosis of pancreatic cancer. The median survival time of 52 patients with pancreatic cancer was 10 months (95% CI7.389~12.611).. Patients with the increasing level of serum CA19-9, CEA, CA125, CA242 had shorter survival times (P=0.047. 0.043, 0.0041, 0.029). COX regression analysis showed that CA19-9 was an independent prognostic factor for patients with pancreatic cancer (P=0.001, 95%CI 2.591~38.243). The detection of serum tumor markers (CA19.9, CEA, CA125 and CA242) is conducive to the early diagnosis of pancreatic cancer and joint detection of tumor markers helps improve the diagnostic efficiency. Moreover, CA19-9 is an independent prognostic factor for patients with pancreatic cancer.

  14. ÓXIDO NÍTRICO E DINÂMICA DE CA2+ EM CARDIOMIÓCITOS: INFLUÊNCIA DA CAPACIDADE DE EXERCÍCIO

    Directory of Open Access Journals (Sweden)

    Lucas Rios Drummond

    2016-02-01

    Full Text Available RESUMO Introdução: A capacidade intrínseca para o exercício aeróbico está relacionada com o inotropismo cardíaco. Por outro lado, a participação do óxido nítrico (NO como mensageiro intracelular sobre a dinâmica do Ca2+ ainda permanece desconhecida em ratos com diferentes capacidades intrínsecas para o exercício. Objetivo: Avaliar se o NO modula diferentemente o transiente intracelular de Ca2+ e liberações espontâneas de Ca2+(sparks em cardiomiócitos de ratos com diferentes capacidades intrínsecas para o exercício. Métodos: Ratos machos Wistar foram selecionados como desempenho padrão (DP e alto desempenho (AD, de acordo com a capacidade de exercício até a fadiga, mensurada através de teste de esforço progressivo em esteira. Os cardiomiócitos dos ratos foram utilizados para determinar o transiente intracelular de Ca2+ e Ca2+sparks em microscópio confocal. Para estimar a contribuição do NO foi utilizado o inibidor das sínteses do NO (L-NAME, 100 µM. Os dados foram analisados através de ANOVA two-way seguido do pós-teste de Tukey e apresentados como médias ± EPM. Resultados: Os cardiomiócitos de ratos AD exibiram aumentos na amplitude do transiente de Ca2+ em comparação aos DP. Entretanto, o L-NAME aumentou a amplitude do transiente de Ca2+ somente em ratos DP. Não foram encontradas diferenças na constante de tempo de decaimento do transiente de Ca2+ (t em cardiomiócitos de ratos com DP e AP, contudo, a administração do L-NAME diminuiu o t em cardiomiócitos em ambos os grupos. cardiomiócitos de ratos AD apresentaram menor amplitude e frequência de Ca2+sparks em comparação ao grupo DP. A administração de L-NAME aumentou a amplitude de Ca2+sparks em cardiomiócitos do grupo AD. Conclusão: O NO modula o transiente de Ca2+ e as sparks de Ca2+ em cardiomiócitos de ratos com diferentes capacidades intrínsecas para o exercício.

  15. Study on Ca2+ antagonistic effect and mechanism of Chinese herbal drugs using 45Ca

    International Nuclear Information System (INIS)

    Yang Yuanyou; Liu Ning; Mo Shangwu; Qiu Mingfeng; Jin Jiannan; Liao Jiali

    2002-01-01

    The Ca 2+ antagonistic effect and mechanism of Chinese herbal drugs are studied by using 45 Ca. The results indicate that potential-dependent Ca 2+ channel (PDC) and receptor-operated Ca 2+ channel (ROC) in cell membranes of smooth muscle can be blocked by several Chinese herbal drugs, including as Crocus sativus L., Carthamus L., Di-ao-xin-xue-kang (DAXXG) and Ginkgo biloba L. leaves. Among them Crocus sativus L. has the strongest antagonistic effect on Ca 2+ channel, while Ginkgo biloba L. leaves has no obvious effect. The whole prescription and the other functional drugs have significant effect on ROC and PDC. The compositions extracted by hexane have the strongest antagonistic. The wrinkled giant hyssop have five active compositions and Pei-lan have two active compositions

  16. Propuesta para la optimización de los procesos de gestión de recuperación de cartera de fianzas en el departamento de cobranzas de Sul América Compañía de Seguros del Ecuador C.A.

    OpenAIRE

    Plaza Loza, Fabricio Gonzalo

    2011-01-01

    A través del presente trabajo de tesis se busca mejorar e implementar procesos en el campo de cobranzas en Latina Seguros y Reaseguros C.A, antes conocida como Sul América Compañía de Seguros del Ecuador C.A.

  17. MIGRAÇÃO COMO CRIME, ÊXODO COMO LIBERDADE

    Directory of Open Access Journals (Sweden)

    Aryadne Bittencourt Waldely

    Full Text Available Resumo O tratamento securitário dispensado à migração – e aos deslocamentos em geral, incluindo o refúgio – não é excepcional nem secundário. Se a criminalização aparece como evento extraordinário, isso quer dizer apenas que as práticas de securitização não se limitam à punição e que não são exclusivas das instituições de repressão. Ao contrário, estão espalhadas por diversos dispositivos institucionais, práticas e discursos. No caso dos migrantes, refugiados e deslocados em geral, o que está em questão não é exatamente reprimir ou interditar, mas classificar os fluxos, os atos e os sujeitos e docilizar os corpos. E é a fuga em si mesma – seja o deslocamento voluntário ou não – que se torna objeto de tais dispositivos. Neste sentido, é preciso analisar e qualificar os eventos em relação à sua potência e à sua importância política: a criminalização e todos os atos de repressão, docilização e captura são reativos e secundários em relação à fuga; enquanto a fuga é o ato primeiro, o movimento antecedente e capaz de produzir liberdade, justiça e direitos.

  18. Large conductance Ca2+-activated K+ (BK channel: Activation by Ca2+ and voltage

    Directory of Open Access Journals (Sweden)

    RAMÓN LATORRE

    2006-01-01

    Full Text Available Large conductance Ca2+-activated K+ (BK channels belong to the S4 superfamily of K+ channels that include voltage-dependent K+ (Kv channels characterized by having six (S1-S6 transmembrane domains and a positively charged S4 domain. As Kv channels, BK channels contain a S4 domain, but they have an extra (S0 transmembrane domain that leads to an external NH2-terminus. The BK channel is activated by internal Ca2+, and using chimeric channels and mutagenesis, three distinct Ca2+-dependent regulatory mechanisms with different divalent cation selectivity have been identified in its large COOH-terminus. Two of these putative Ca2+-binding domains activate the BK channel when cytoplasmic Ca2+ reaches micromolar concentrations, and a low Ca2+ affinity mechanism may be involved in the physiological regulation by Mg2+. The presence in the BK channel of multiple Ca2+-binding sites explains the huge Ca2+ concentration range (0.1 μM-100 μM in which the divalent cation influences channel gating. BK channels are also voltage-dependent, and all the experimental evidence points toward the S4 domain as the domain in charge of sensing the voltage. Calcium can open BK channels when all the voltage sensors are in their resting configuration, and voltage is able to activate channels in the complete absence of Ca2+. Therefore, Ca2+ and voltage act independently to enhance channel opening, and this behavior can be explained using a two-tiered allosteric gating mechanism.

  19. Cardiac microvascular endothelial cells express a functional Ca+ -sensing receptor.

    Science.gov (United States)

    Berra Romani, Roberto; Raqeeb, Abdul; Laforenza, Umberto; Scaffino, Manuela Federica; Moccia, Francesco; Avelino-Cruz, Josè Everardo; Oldani, Amanda; Coltrini, Daniela; Milesi, Veronica; Taglietti, Vanni; Tanzi, Franco

    2009-01-01

    The mechanism whereby extracellular Ca(2+) exerts the endothelium-dependent control of vascular tone is still unclear. In this study, we assessed whether cardiac microvascular endothelial cells (CMEC) express a functional extracellular Ca(2+)-sensing receptor (CaSR) using a variety of techniques. CaSR mRNA was detected using RT-PCR, and CaSR protein was identified by immunocytochemical analysis. In order to assess the functionality of the receptor, CMEC were loaded with the Ca(2+)-sensitive fluorochrome, Fura-2/AM. A number of CaSR agonists, such as spermine, Gd(3+), La(3+) and neomycin, elicited a heterogeneous intracellular Ca(2+) signal, which was abolished by disruption of inositol 1,4,5-trisphosphate (InsP(3)) signaling and by depletion of intracellular stores with cyclopiazonic acid. The inhibition of the Na(+)/Ca(2+) exchanger upon substitution of extracellular Na(+) unmasked the Ca(2+) signal triggered by an increase in extracellular Ca(2+) levels. Finally, aromatic amino acids, which function as allosteric activators of CaSR, potentiated the Ca(2+) response to the CaSR agonist La(3+). These data provide evidence that CMEC express CaSR, which is able to respond to physiological agonists by mobilizing Ca(2+) from intracellular InsP(3)-sensitive stores. Copyright 2008 S. Karger AG, Basel.

  20. The hippocampal CA2 ensemble is sensitive to contextual change.

    Science.gov (United States)

    Wintzer, Marie E; Boehringer, Roman; Polygalov, Denis; McHugh, Thomas J

    2014-02-19

    Contextual learning involves associating cues with an environment and relating them to past experience. Previous data indicate functional specialization within the hippocampal circuit: the dentate gyrus (DG) is crucial for discriminating similar contexts, whereas CA3 is required for associative encoding and recall. Here, we used Arc/H1a catFISH imaging to address the contribution of the largely overlooked CA2 region to contextual learning by comparing ensemble codes across CA3, CA2, and CA1 in mice exposed to familiar, altered, and novel contexts. Further, to manipulate the quality of information arriving in CA2 we used two hippocampal mutant mouse lines, CA3-NR1 KOs and DG-NR1 KOs, that result in hippocampal CA3 neuronal activity that is uncoupled from the animal's sensory environment. Our data reveal largely coherent responses across the CA axis in control mice in purely novel or familiar contexts; however, in the mutant mice subject to these protocols the CA2 response becomes uncoupled from CA1 and CA3. Moreover, we show in wild-type mice that the CA2 ensemble is more sensitive than CA1 and CA3 to small changes in overall context. Our data suggest that CA2 may be tuned to remap in response to any conflict between stored and current experience.

  1. Clinical Value of Combined Detection of PG-I, CA72-4 and TSGF in the Diagnosis of Gastric Carcinoma

    International Nuclear Information System (INIS)

    Dai Feng; Wu Jiayin

    2010-01-01

    To explore the clinical significance of combined detection of serum pepsinogen I(PG-I), carbohydrate antigen 72-4 (CA72-4) and tumor supplied group of factor(TSGF) in patients with gastric carcinoma, the serum PG-I, CA72-4 and TSGF in patients with gastric carcinoma, chronic superficial gastritis, chronic atrophic gastritis,gastric ulcer and normal controls were detected by immunoradiometric assay, electrochemluminescence immunoassay and biochemical colorimetry respectively. The results showed that the serum level of PG-I (36.76±10.16 ug/L) in patients with gastric carcinoma was remarkably lower than that in controls, and the serum levels of CA72-4 (5.92±2.53 U/ml) and TSGF (107±15.3 U/ml) in patients with gastric carcinoma were significantly higher than those in other groups. The positive rates of PG-I, CA72-4 and TSGF in patients with gastric carcinoma were 42.85%, 42.85% and 45.71% respectively. The positive rate of combined detection was 80%. The serum levels of PG-I, CA72-4 and TSGF are related to the biology behavior of gastric carcinoma. The detection of serum PG-I, CA72-4 and TSGF would help to judge the metastasis and prognosis of gastric carcinoma. The combined detection of the three marks could increase the diagnosis accuracy of gastric carcinoma. (authors)

  2. PROHEXADIONA-CA, UNA ALTERNATIVA EN LA PRODUCCIÓN DE TOMATE DE CÁSCARA (Physalis ixocarpa Brot.

    Directory of Open Access Journals (Sweden)

    H. Ramírez

    2010-01-01

    Full Text Available El tomate de cáscara, por su superficie cultivada y su constante aumento en el consumo per capita, se considera una de las principales hortalizas en México. Se cultiva en cualquier región del país, aunque con una producción media nacional por debajo de su potencial. Prohexadiona de Ca (P-Ca, es un retardante del crecimiento señalado recientemente como una alternativa prometedora en la horticultura moderna, principalmente para mejorar la producción y calidad del producto cosechado. Con base en lo anterior, se evaluaron los efectos de P-Ca sobre el crecimiento vegetativo y productivo; así como las propiedades químicas del fruto en tomate de cáscara. Se realizaron dos aplicaciones de P-Ca a diferentes dosis (0, 125, 175 y 200 mg·litro-1. La primera se realizó cuando las plantas presentaron primordios florales y la segunda 20 días después. Con un diseño en bloques completos al azar y una comparación de medias con la prueba DMS a una P¿0.05, se demostró que P-Ca redujo significativamente la altura de la planta, aumentó notablemente el número de frutos, el rendimiento por planta (200 mg·litro-1, el contenido de vitamina C en frutos (175 y 200 mg·litro-1 y la actividad enzimática catalasa (175 mg·litro-1. Las variables de tamaño y peso de fruto, el contenido de proteína, la actividad enzimática peroxidasa y el contenido mineral en fruto no fueron afectados por P-Ca.

  3. LA CTE "OTTO PARELLADA" (TALLAPIEDRA COMO BASE MATERIAL DE ESTUDIO

    Directory of Open Access Journals (Sweden)

    Alberto E Calvo González

    2011-03-01

    Full Text Available Se presenta el análisis de las posibilidades que tiene la CTE" Otto Parellada" como elemento fundamental en la formación de ingenieros electricistas, así como para otras especialidades.Se expone el modo en que actualmente se le aprovecha para la carrera de Ingeniería Eléctrica en ladisciplina de Centrales Termoeléctricas, así como para la carrera de Ingeniería Mecánica en la asignatura homónimadel 1er. año. Se exponen otras posibilidades de la planta que podrían ser explotadas aún por otras carreras comoArquitectura, al tener características que la avalan como Patrimonio Industrial.  In this paper is presented the analysis of the possibilities like fundamental element that Otto Parellada SteamPower Plant has for the electrical, as well as other specialties engineers' syllabus. The way that at present time isused for the electrical engineers education, in the thermal engineering subjects is exposed, as well as for themechanical engineering in the 1st year. Other possibilities of the plant that could still be exploited by otherscareers like architecture, due to the characteristic that endorse it as Industrial Patrimony are also exposed.

  4. A montagem cinematográfica como ato criativo

    Directory of Open Access Journals (Sweden)

    Maria Dora Genis Mourão

    2006-06-01

    Full Text Available O foco deste trabalho é refletir sobre a montagem cinematográfica como ato criativo, não a montagem pensada como simples agenciadora de planos, mas como criadora de sentidos. É na maneira como o cinema articula e aproxima as imagens e os sons que verificamos sua transformação em discurso. Criam-se novos sentidos, uma nova lógica onde os significados não são transparentes, nascida da associação de fragmentos. Justapõem-se duas realidades: a da vida propriamente dita e a do filme, a do discurso e, ainda dentro do filme, a justaposição de planos determinando novas leituras das Imagens. Partindo dos princípios da teoria da montagem cinematográfica de S. M. Eisenstein, faremos um rápido panorama de como o cinema, no decorrer de sua história, foi influenciado pelos conceitos desenvolvidos em sua teoria.

  5. Aprendizagem como/na prática

    Directory of Open Access Journals (Sweden)

    Jean Lave

    2015-12-01

    Full Text Available ResumoEste artigo considera como o estudo da cultura e da aprendizagem pode ser de particular relevância para o campo da antropologia sociocultural em geral. O termo mais importante na expressão “cultura & aprendizagem” talvez seja o logograma “&” – ou seja, coloca-se a questão sobre o que conecta cultura e aprendizagem, perguntando-se como esses termos estão relacionados. Como devemos compreender cultura e aprendizagem como instâncias produtoras delas próprias, e uma da outra, na prática? Recalibrando em termos relacionais, podemos dizer que não é possível abordar a “aprendizagem” ou “cultura e aprendizagem” sem o seu emaranhamento na vida político-econômica, nas lutas e disputas históricas, em suas coerências e incoerências, e na produção relacional e histórica da vida cotidiana. Através das lentes da teoria da prática social, os estudos etnográficos sobre aprendizagem na prática oferecem diferentes entendimentos sobre como certa vida e certas disputas e incoerências são produzidas.

  6. Numerical model of Ca(OH)

    NARCIS (Netherlands)

    Koster, T.; Peelen, W.; Larbi, J.; Rooij, M. de; Polder, R.

    2010-01-01

    A mathematical model is being developed to describe a repair method in concrete, called cathodic protection (CP). The model is in principle also useful to describe electrodeposition in concrete, e.g. the process of re-precipitation of Ca(OH)2 invoked by an electrical current. In CP, the

  7. Gene of the month: PIK3CA.

    Science.gov (United States)

    Lai, K; Killingsworth, M C; Lee, C S

    2015-04-01

    PIK3CA encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) which through its role in the PI3K/Akt pathway is important for the regulation of important cellular functions such as proliferation, metabolism and protein synthesis, angiogenesis and apoptosis. Mutations in PIK3CA are known to be involved in a wide range of human cancers and mutant PIK3CA is thought to act as an oncogene. The specific PIK3CA inhibitor, NVP-BYL719, has displayed promising results in cancer therapy and is currently under clinical trials. Furthermore, PI3K regulates autophagy, a cellular process that recycles proteins and organelles through lysosomal degradation and has recently been recognised as an attractive therapeutic target due to its pro- and anti-cancer properties. Several studies have attempted to investigate the effects of combining the inhibition of both PI3K and autophagy in cancer therapy, and an in vivo model has demonstrated that the combined use of a concomitant PI3K and autophagy inhibitor induced apoptosis in glioma cells. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  8. Exchange stiffness of Ca-doped YIG

    Science.gov (United States)

    Avgin, I.; Huber, D. L.

    1994-05-01

    An effective medium theory for the zero-temperature exchange stiffness of uncompensated Ca-doped YIG is presented. The theory is based on the assumption that the effect of the Ca impurities is to produce strong, random ferromagnetic interactions between spins on the a and d sublattices. In the simplest version of the theory, a fraction, x, of the ad exchange integrals are large and positive, x being related to the Ca concentration. The stiffness is calculated as function of x for arbitrary perturbed ad exchange integral, Jxad. For Jxad≳(1/5)‖8Jaa+3Jdd‖, with Jaa and Jdd denoting the aa and dd exchange integrals, respectively, there is a critical concentration, Xc, such that when x≳Xc, the stiffness is complex. It is suggested that Xc delineates the region where there are significant departures from colinearity in the ground state of the Fe spins. Extension of the theory to a model where the Ca doping is assumed to generate Fe4+ ions on the tetrahedral sites is discussed. Possible experimental tests of the theory are mentioned.

  9. Ca teos report in register N 13377

    International Nuclear Information System (INIS)

    Pena, S; Arrighetti, R.

    2011-01-01

    This work is about a report about ca teos carried out in register N 13377 in the department of Canelones to know the depth of the field. The drilling done allowed to identify granite and clay. This granite outcrops are developed in the east of the middle course of the stream Pando

  10. literacy.ca EXPRESS. April 2010

    Science.gov (United States)

    Movement for Canadian Literacy, 2010

    2010-01-01

    This issue of "literacy.ca EXPRESS" focuses on poverty. The articles included in this issue are: (1) Poverty Overview; (2) Tony's Story; (3) LAN (Learner Advisory Network) Member's Story (Dianne Smith); (4) Linking Adult Literacy to Poverty Reduction; (5) MCL (Movement for Canadian Literacy) Update; (6) Highlights from the LAN; (7) Good…

  11. The study of skeletal calcium metabolism with 41Ca and 45Ca

    Science.gov (United States)

    Freeman, Stewart P. H. T.; Beck, Belinda; Bierman, June M.; Caffee, Marc W.; Heaney, Robert P.; Holloway, Leah; Marcus, Robert; Southon, John R.; Vogel, John S.

    2000-10-01

    The living skeleton can be labeled for life by the administration of radiologically trivial amounts of 41Ca tracer. After initial elimination of tracer from the readily exchangeable calcium pools subsequent skeletal calcium turnover maintains and modulates the urine 41Ca content. Uniquely, bone calcium metabolism may then be studied with tracer in near equilibrium with the body's calcium and resorbing calcium directly measured by accelerator mass spectrometry (AMS) of excreta. Our experiments with 25 41Ca labeled subjects demonstrate excellent diurnal stability and remarkable response to intervention of the urine signal. Thus the tracer method may prove a competitive means of measuring the effects of antiresorptive osteoporosis treatments, for therapy development or even clinical monitoring. Novel studies of long-term skeletal evolution are also possible. We realize that routinely administered short-lived calcium radiotracers contain 41Ca impurities and that thousands of experimental participants have been historically inadvertently 41Ca labeled. The 41Ca urine index might now rapidly further be characterized by contemporary measurements of these one-time subjects, and with their by now thoroughly skeleton-equilibrated tracer they might be ideal participants in other new experiments. We are also investigating 45Ca AMS. It may prove preferable to label the skeleton with this radiotracer already familiar to bioscientists, but new to AMS.

  12. The correlation characteristics of sup 9 Be(d, p gamma) sup 1 sup 0 Be reaction at E sub d = 15.3 MeV and structure of sup 1 sup 0 Be nucleus

    CERN Document Server

    Zelenskaya, N S; Lebedev, V M; Orlova, N V; Spasskij, A V

    2001-01-01

    The results of measurements of double differential cross sections of the sup 9 Be(d, p gamma) sup 1 sup 0 Be reaction at E sub d = 15.3 MeV in the forward hemisphere proton ejection angles are presented. The modelless restoration of all even spin-tensor components of the density matrix of the 2 sup + (3.37 MeV) state of residual nucleus is reduced. The angular dependences of magnetic substate population and moment orientation tensor components for this state are also obtained. The experimental results are compared with calculations incorporating the neutron stripping mechanism by coupled-channel method. A large sensitivity of the calculated correlation characteristics to wave functions of nuclei participating in reaction, especially for nucleus sup 1 sup 0 Be is pointed out. It is demonstrated that taking the multistep processes into account is important for the investigated reaction

  13. Mg-Ca Alloys Produced by Reduction of CaO: Understanding of ECO-Mg Alloy Production

    Science.gov (United States)

    Jung, In-Ho; Lee, Jin Kyu; Kim, Shae K.

    2017-04-01

    There have been long debates about the environment conscious (ECO) Mg technology which utilizes CaO to produce Ca-containing Mg alloys. Two key process technologies of the ECO-Mg process are the chemical reduction of CaO by liquid Mg and the maintenance of melt cleanliness during the alloying of Ca. Thermodynamic calculations using FactSage software were performed to explain these two key issues. In addition, an experimental study was performed to compare the melt cleanliness of the Ca-containing Mg alloys produced by the conventional route with metallic Ca and the ECO-Mg route with CaO.

  14. DA-6034 Induces [Ca(2+)]i Increase in Epithelial Cells.

    Science.gov (United States)

    Yang, Yu-Mi; Park, Soonhong; Ji, Hyewon; Kim, Tae-Im; Kim, Eung Kweon; Kang, Kyung Koo; Shin, Dong Min

    2014-04-01

    DA-6034, a eupatilin derivative of flavonoid, has shown potent effects on the protection of gastric mucosa and induced the increases in fluid and glycoprotein secretion in human and rat corneal and conjunctival cells, suggesting that it might be considered as a drug for the treatment of dry eye. However, whether DA-6034 induces Ca(2+) signaling and its underlying mechanism in epithelial cells are not known. In the present study, we investigated the mechanism for actions of DA-6034 in Ca(2+) signaling pathways of the epithelial cells (conjunctival and corneal cells) from human donor eyes and mouse salivary gland epithelial cells. DA-6034 activated Ca(2+)-activated Cl(-) channels (CaCCs) and increased intracellular calcium concentrations ([Ca(2+)]i) in primary cultured human conjunctival cells. DA-6034 also increased [Ca(2+)]i in mouse salivary gland cells and human corneal epithelial cells. [Ca(2+)]i increase of DA-6034 was dependent on the Ca(2+) entry from extracellular and Ca(2+) release from internal Ca(2+) stores. Interestingly, these effects of DA-6034 were related to ryanodine receptors (RyRs) but not phospholipase C/inositol 1,4,5-triphosphate (IP3) pathway and lysosomal Ca(2+) stores. These results suggest that DA-6034 induces Ca(2+) signaling via extracellular Ca(2+) entry and RyRs-sensitive Ca(2+) release from internal Ca(2+) stores in epithelial cells.

  15. New limits on 2β processes in 40Ca and 46Ca by using low radioactive CaF2(Eu) crystal scintillators

    International Nuclear Information System (INIS)

    Belli, P.; Bernabei, R.; Dai, C.J.

    2001-01-01

    The development of highly radiopure CaF 2 (Eu) crystal scintillators has been performed aiming at a substantial sensitivity enhancement of the 2β decay investigation and of the search for dark matter particles with spin-dependent (SD) interaction. The results of CaF 2 (Eu) background measurements and simulation are presented. New and highly improved T 1/2 limits on the 2β decay of 46 Ca and the double electron capture of 40 Ca are obtained

  16. Los portales educativos como fuente de recursos materiales

    Directory of Open Access Journals (Sweden)

    Felipe Gértrudix Barrio

    2012-04-01

    Full Text Available Los portales educativos por sus características como “distribuidores” de información y “almacenes” de recursos, constituyen para la escuela actual un soporte ideal y eficiente de información relacionado con el mundo educativo. Por otro lado, los portales temáticos educativos, como referente específico de una materia, suponen la plataforma ideal en el que los miembros de un colectivo (profesores, maestros, educadores y familias puedan establecer un punto de encuentro para participar, reflexionar, así como cooperar en la actividad docente incentivando nuevas formas de trabajo en el aula. En este sentido presentamos un ejemplo de portal temático educativo dedicado a la educación musical: MOS.

  17. A verdade como um problema epistemológico

    Directory of Open Access Journals (Sweden)

    Geilson Fernandes de Oliveira

    2016-07-01

    Full Text Available O presente ensaio é fruto das discussões realizadas durante a disciplina de mestrado Epistemologia das Ciências Sociais e Humanas. Aqui, objetivamos discutir sobre a verdade como um problema epistemológico. Assim, a partir do conceitual teórico utilizado durante a disciplina, entre os quais destacamos Michel Foucault, Norbert Elias, Friedrich Nietzsche e Pierre Bourdieu, tecemos considerações sobre as concepções de verdade no pensamento social contemporâneo, bem como no que diz respeito as rupturas que favoreceram a emergência de seu estado corrente – concepção da verdade como produção social e histórica. Consonante a esta discussão, realizamos ainda uma breve discussão sobre as relações de poder e saber que favorecem a constituição da verdade.

  18. O SERTÃO COMO FORMA DE PENSAMENTO

    Directory of Open Access Journals (Sweden)

    Willi Bolle

    1998-10-01

    Full Text Available Focalizando um micromodelo do sertão, o "Liso do Sussuarão", este ensaio es tuda a construção da paisagem em Grande sertão: veredas como componente de um retrato do Brasil. Partindo do confronto entregeografia inventada e geografia rea l, examina-se a tese rosiana do sertãocomo um "pensamento" que "se forma mais forte do que o poder do lugar", comparando essa tese com o paradigma dos viajantes naturalistas, o determinismo positivista de Euclides da Cunha e a nova historiografia. Como traço estilístico dominante é detectado um modo de escreverque S€ pode chamar de "poética da dissolução", pela qual o romance de Rosa se configura como um poderoso dissolvente de outros tipos de discursos sobre o Brasil.

  19. La subjetividad como superación del reproductivismo

    Directory of Open Access Journals (Sweden)

    Gabriela Yamila Gómez

    2013-01-01

    Full Text Available El artículo tiene como objetivo recuperar la esfera de lo subjetivo como eje de la teoría y de la investigación social. Se proponen dos argumentos principales: a el abordaje de la subjetividad no equivale a subjetivismo; y b tampoco equivale a una mirada microsociológica que no dé cuenta de los procesos sociales generales. Partiendo de estas dos premisas, el estudio del mundo de la vida experimentado y realizado por los sujetos permitirá superar el reproductivismo, comprendiendo la relación entre las condiciones objetivas y subjetivas, así como la posibilidad y existencia del cambio social.

  20. LA PARTICIPACION EN LA SOCIEDAD COMO BASE DEL DESARROLLO

    Directory of Open Access Journals (Sweden)

    María Cecilia Múnera López

    2012-11-01

    Full Text Available A explicação dela participação na sociedade como a base para o desenvolvimento é o resultado dum processo longo de pesquisa, que no âmbito da teoria fundamentada, tem chegado a aspetos essenciais de ordem conceitual e metodológica, que sustentam o desenvolvimento e a participação. Assim, este artigo apresenta o desenvolvimento desde uma perspectiva resignificada, entendida como uma construção sociocultural múltipla, histórica e territorialmente determinada. De acordo com tal renovação teórica, se apresenta uma forma tipológica de participação, chamada "participação sinérgica", como uma opção plausível para impactar positivamente o desenvolvimento.

  1. LA UTOPÍA FEMINISTA COMO TRANSGRESIÓN

    Directory of Open Access Journals (Sweden)

    Maria Luisa Femenias

    2013-04-01

    Full Text Available Resumen Tal como sucede –según lo enunció Kate Millet hace más de cincuenta años- respecto de las vanguardias literarias de comienzos del siglo XX, las estudiosas actuales de la literatura utópica reconocen que el esquema tradicional seguido por los escritores varones es “utópico” en todos sus aspectos, menos en la deconstrucción de los roles de sexo-género. Sobre este marco general, revisaré la noción de “utopía feminista” como transgresión al modelo canónico y, a su vez, desafío al orden social considerado “natural”. Para ello, examinaré algunos problemas vinculados a la caracterización de la literatura utópica como tal, y el frecuente abandono de sus fundamentos filosóficos.

  2. Effects of Ca on microstructure, mechanical and corrosion properties and biocompatibility of Mg-Zn-Ca alloys.

    Science.gov (United States)

    Yin, Ping; Li, Nian Feng; Lei, Ting; Liu, Lin; Ouyang, Chun

    2013-06-01

    Zn and Ca were selected as alloying elements to develop an Mg-Zn-Ca alloy system for biomedical application due to their good biocompatibility. The effects of Ca on the microstructure, mechanical and corrosion properties as well as the biocompatibility of the as-cast Mg-Zn-Ca alloys were studied. Results indicate that the microstructure of Mg-Zn-Ca alloys typically consists of primary α-Mg matrix and Ca₂Mg₆Zn₃/Mg₂Ca intermetallic phase mainly distributed along grain boundary. The yield strength of Mg-Zn-Ca alloy increased slightly with the increase of Ca content, whilst its tensile strength increased at first and then decreased. Corrosion tests in the simulated body fluid revealed that the addition of Ca is detrimental to corrosion resistance due to the micro-galvanic corrosion acceleration. In vitro hemolysis and cytotoxicity assessment disclose that Mg-5Zn-1.0Ca alloy has suitable biocompatibility.

  3. Reassigning the CaH+ 11Σ → 21Σ vibronic transition with CaD+

    Science.gov (United States)

    Condoluci, J.; Janardan, S.; Calvin, A. T.; Rugango, R.; Shu, G.; Sherrill, C. D.; Brown, K. R.

    2017-12-01

    We observe vibronic transitions in CaD+ between the 11Σ and 21Σ electronic states by resonance enhanced multiphoton photodissociation spectroscopy in a Coulomb crystal. The vibronic transitions are compared with previous measurements on CaH+. The result is a revised assignment of the CaH+ vibronic levels and a disagreement with multi-state-complete-active-space second-order perturbation theory theoretical calculations by approximately 700 cm-1. Updated high-level coupled-cluster calculations that include core-valence correlations reduce the disagreement between theory and experiment to 300 cm-1.

  4. Mg and Ca isotope fractionation during CaCO3 biomineralisation

    International Nuclear Information System (INIS)

    Chang, Veronica T.-C.; Williams, R.J.P.; Makishima, Akio; Belshawl, Nick S.; O'Nions, R. Keith

    2004-01-01

    The natural variation of Mg and Ca stable isotopes of carbonates has been determined in carbonate skeletons of perforate foraminifera and reef coral together with Mg/Ca ratios to assess the influence of biomineralisation processes. The results for coral aragonite suggest its formation, in terms of stable isotope behaviour, approximates to inorganic precipitation from a seawater reservoir. In contrast, results for foraminifera calcite suggest a marked biological control on Mg isotope ratios presumably related to its low Mg content compared with seawater. The bearing of these observations on the use of Mg and Ca isotopes as proxies in paleoceanography is considered

  5. Thermoluminescence of CaCO3:Dy and CaCO3:Mn

    International Nuclear Information System (INIS)

    Bapat, V.N.; Nambi, K.S.V.

    1976-01-01

    CaCO 3 samples doped with Dy and Mn were prepared in the laboratory by co-precipitation techniques. Thermoluminescence and emission spectra of these phosphors were studied and were compared with those of the naturally occuring calcite and undoped CaCO 3 samples. Dy-doping seems to give a more efficient phosphor and indicates a possibility of getting a better phosphor by a judicious choice of a rare earth doping of CaCO 3 . Interesting result have been obtained on the TL glow curve variations of these phosphors with different temperature treatments prior to irradiation. (author)

  6. Turismo musical y patrimonio cultural como recursos educativos

    OpenAIRE

    Ramos Ahijado, Sonsoles; Botella Nicolás, Ana María

    2017-01-01

    La música es el más singular tipo de patrimonio cultural, que motiva desplazamientos turísticos, ya que para muchos viajeros cumple un rol importante en sus itinerarios. El turismo y el consumo cultural adquieren de este modo una gran relevancia, como fuente de riqueza y seña de identidad de la sociedad. En este artículo forma parte de una investigación de mayores dimensiones sobre la música como recurso para la promoción turística. Así, teniendo presente las nuevas tendencias del interés tur...

  7. Historia como interrupción del tiempo

    OpenAIRE

    Aguilera Pedrosa, Antonio

    2006-01-01

    Frente a un concepto de presente como transición y a otro como repetición, Benjamín elabora uno donde el tiempo se detiene, clave para entender su concepto de historia. La interpretación habitual que separa tiempo histórico de tiempo físico quiere facilitar la comprensión de Benjamin, pero al precio de olvidar ciertas paradojas: la misma detención, la reversibilidad del tiempo, la redención del pasado entero, la invocación de la teología, la posibilidad de un cambio respecto al tiempo natural...

  8. Pegada Hídrica como Indicador de Sustentabilidade Ambiental1

    OpenAIRE

    Kettrin Farias Bem Maracajá; Vicente de Paulo Rodrigues da Silva; José Dantas Neto; niversidade Federal de Campina Grande

    2012-01-01

    O conceito de pegada hídrica tem sido recentemente introduzido como um importante indicador do consumo de água humano, na tentativa de minimizar os impactos ambientais. Esse trabalho aborda o conceito da pegada hídrica como um indicador de sustentabilidade, com vistas o uso racional dos recursos hídricos. Nos últimos anos, a escassez de alguns recursos naturais vem sendo bastante discutido em todo o mundo e quanto à água a preocupação é ainda maior em face do uso desordenado na irrig...

  9. El Leasing como herramienta de financiación

    OpenAIRE

    Chorén, María Cecilia

    2015-01-01

    El siguiente trabajo de investigación es planteado para ser utilizado por las Pymes para evaluar la oportunidad de aplicar el Leasing frente a una posibilidad de inversión en activos fijos; ya que hoy en día es tenido en cuenta en los países desarrollados como la herramienta de financiamiento más conveniente y perfecto que existe debido a sus amplios beneficios. Este trabajo tiene como objetivo primordial establecer las ventajas impositivas, jurídicas, financieras y operativas para que las...

  10. La comunicación, como herramienta de productividad

    Directory of Open Access Journals (Sweden)

    Lic. Johnny Vargas D.

    1998-01-01

    Full Text Available En el ámbito corporativo o empresarial está cobrando auge la comunicación y ya se concibe al gerente moderno como "el gran comunicador", dejando a sus asesores inmediatos la realización de tareas más especializadas. En las empresas contemporáneas, el personal requiere tener información oficializada que le permite comprender su diario quehacer y le oriente productiva y personalmente. Un sistema de comunicación integral en el ámbito empresarial es otro componente de la producción, tan importante como la materia prima o los recursos financieros.

  11. Modelo para sistemas da qualidade como base da estrategia competitiva

    OpenAIRE

    Marco Antonio Silveira

    1999-01-01

    Resumo: Vários autores propõem a empresa como um sistema em transformação, sendo que esse enfoque sistêmico parece oferecer um meio efetivo de prover as capacidades estratégicas que são valorizadas pelos mercados atuais. Por outro lado, vem crescendo a consciência para o enfoque da qualidade como base da estratégia competitiva, onde esta é associada à lucratividade e incluída no processo de planejamento estratégico, tornando-se um instrumento eficaz de concorrência que, para fazer frente à di...

  12. Octadecanoides como reguladores de la defensa de las plantas

    OpenAIRE

    G. Camarena Gutiérrez

    2002-01-01

    En años recientes muchas moléculas lipoides muy potentes han sido identificadas, comprenden compuestos lipofílicos no derivados de lípidos como los brasinoesteroides triterpenoides, otros que parcialmente son de origen lipídico como los lipo-oligosacáridos, factores de nodulación de especies de Rhizobium que pueden tener parientes endógenos en las plantas, y un tercer grupo, los octadecanoides, cuyas estructuras son derivadas de ácidos grasos vegetales. Las señales mediadas por lípid...

  13. Lazer como pratica educativa : as possibilidades para o desenvolvimento humano

    OpenAIRE

    Maira Ivone Lombardi

    2005-01-01

    Resumo: Os objetivos principais deste trabalho consistem em conhecer as inter-relações existentes entre lazer, educação, animação sociocultural e desenvolvimento humano integral e quais as possibilidades de se contribuir para a emancipação do indivíduo na sociedade, utilizando o lazer como prática educativa. Já os objetivos mais específicos são fundamentais à proposição de que o lazer como prática educativa, com base nos seis conteúdos culturais do lazer, pode contribuir para a formação de um...

  14. La prosodia como identificador biométrico

    OpenAIRE

    Farrús i Cabeceran, Mireia

    2011-01-01

    La biometría tiene como objetivo el reconocimiento de personas mediante uno o más identificadores biométricos como la voz, la cara o las huellas dactilares, entre otros. Gracias a la buena aceptación social y el poco intrusismo en los individuos, la voz ha sido, tradicionalmente, uno de los identificadores más utilizados en los sistemas biométricos. Estos sistemas de reconocimiento basados en la voz utilizan, habitualmente, características relacionadas con el espectro de la voz. No obstante, ...

  15. Los youtubers como nuevos referentes sociales de los nativos digitales

    OpenAIRE

    Arias Delgado, Clara

    2017-01-01

    El presente Trabajo Fin de Grado estudia la capacidad de influencia de los ‘youtubers’ españoles con más suscriptores en España y como el consumo de esta plataforma afecta y modifica las pautas tradicionales de consumo digital de los más jóvenes. Para abordar el estudio se ha realizado un exhaustivo análisis basado en los vídeos producidos por 10 youtubers tomados como muestra durante el mes de octubre de 2016. A través del presente estudio se pretende abordar la capacidad de los youtubers pa...

  16. Limitaciones del IMC como indicador exclusivo de estado nutricional

    OpenAIRE

    Moreno Romero, Susana; Dipierri, José Edgardo; Marrodán, María D.

    2007-01-01

    El presente trabajo tiene como objetivo determinar el potencial diagnóstico y las limitaciones del uso del Índice de Masa Corporal como único indicador del estado nutricional. Para ello se analizó una muestra constituida por 2155 sujetos de ambos sexos, con edades comprendidas entre los 6 y 18 años y pertenecientes a tres poblaciones jujeñas que difieren en ubicación altitudinal y nivel socieconómico (NSE): 1.) Susques, localidad rural situada a 3675 m.s.n.m; 2.) Alto Comedero, barrio perifér...

  17. La religión como asignatura no confesional

    OpenAIRE

    Rodríguez Acevedo, Cruz Javier

    2016-01-01

    Las Constituciones de los estados de la Organización de Seguridad y Cooperación Europea (OSCE) establecen como derecho fundamental la educación de sus ciudadanos o nacionales. En el contexto del correlativo deber estatal de facilitar una enseñanza integral, se discute si el estado se debe de ocupar de la enseñanza de la religión como asignatura. A este propósito en els eno de la OSCE se elaboró un documento, "Los principios orientadores de Toledo sobre la enseñanza acerca de las religiones y ...

  18. El rasgo invariante como respuesta subjetiva en el autismo

    OpenAIRE

    Torres, Mónica Miriam

    2015-01-01

    Trascendiendo las diversas presentaciones posibles del autismo, ya la psiquiatría clásica recortaba rasgos constantes, invariantes que se desplegaban en todos los casos. Estos fenómenos en cuestión fueron considerados desde la fundación del cuadro clínico por Leo Kanner en 1943, como gravísimos trastornos. A pesar de que además de aparecer de manera drástica impregnando el cuadro también surgían en otros casos al modo de rasgos discretos y sutiles - como lo mencionaba Hans Asperger en las des...

  19. Factores de riesgo y consecuencias de las caídas en los residentes de un Centro Geriátrico Asistido.

    OpenAIRE

    García Gollarte, J. F.; Antón, C.; Espejo Tort, Begoña

    1994-01-01

    Estudio Realizado sobre el fenómeno de las caídas con una muestro de 79 ancianos de un Centro Geriátrico Asistido para valorar la incidencia de determinados factores de riesgo intrínsecos y extrínsecos, así como sus consecuencias físicas y psíquicas (síndrome post-caída), evolución y tratamiento. El 80% de los ancianos sufrieron alguna caída. Las pruebas estadísticas realizadas mostraron que los ancianos que consumen benzodiacepinas e hipnóticos presentan mayor número de caídas que los que no...

  20. Evaluación del riesgo de caídas en las personas mayores: ¿cómo hacerlo?

    Directory of Open Access Journals (Sweden)

    Lucélia Terra Jonas

    Full Text Available Este artículo de reflexión es fruto de cuestionamientos sobre la evaluación del riesgo de caídas en personas ancianas y sobre los instrumentos disponibles para su medición. Tiene como propósito reflejar la necesidad de elaborar un instrumento evaluativo del riesgo de caídas en personas ancianas. Dicho instrumento podrá facilitar la identificación de los factores de riesgo de caídas y, a partir de ello, la propuesta de intervenciones efectivas en la prevención de caídas en personas ancianas, con el objetivo de preservar su calidad de vida, el mantenimiento de su seguridad, la no institucionalización y, en consecuencia, la reducción de costos para la atención secundaria y terciaria.

  1. Mejoramiento de Vivienda como Estrategia de Control de la Enfermedad de Chagas.

    Directory of Open Access Journals (Sweden)

    Victor Manuel Ángulo

    2000-08-01

    Full Text Available

    El Proceso en Colombia.

    La Constitución Política de 1991 en el artículo 51 estableció que todos los colombianos tienen derecho a una vivienda digna. Para dar cum-plimiento a este mandato se instituyó la ley 3 de 1991 que creó el subsidio de vivienda y el sistema SISBEN. El desarrollo estatutario de esta ley dejó en manos de la Red de Solidaridad Social (RSS y la Caja Agraria (CA la metodología para que las comunidades de los diferentes entes territoriales puedan acceder a los recursos del subsidio. Esta metodología permite a la colectividad formular los proyectos destinados a la consecución de recursos para los departamentos o regiones y concertar en una mesa colegiada de alcaldes, la focalización de éstos.

    Por otro lado, en 1994 se comenzó a diseñar el plan para la elaboración del Programa Nacional de Promoción, Prevención y Control de la Enfermedad de Chagas, al tiempo que en el departamento de Santander a través del CINTROP-UIS y la Secretaría de Salud, se realizaban estudios sobre la situación de infestación domiciliaria por triatominos y las características físicas de las viviendas en las comunidades rurales, con el fin de ejecutar un proyecto que le permitiera evaluar las estrategias de control del vector.

    Estos estudios mostraron la alta prevalencia de infestación domiciliaria por triatominos que aún existe en amplias zonas rurales. De igual manera, se pudo conocer la influencia que tiene la calidad de la vivienda como factor de riesgo para la domiciliación de triatominos. El desarrollo de la ley de descentralización municipal y el enfoque intersectorial e interinstitucional permitieron incluir dentro de la evaluación de estrate-gias para el control de triatominos, el mejoramiento de vivienda y dentro de los proyectos de mejoramiento de vivienda el concepto de salud: vivienda buena, salud para la familia.

    Los alcaldes como responsables de la focali-zación de los

  2. Danzas como tradición y como disputa: la ilusión comunitaria china en el Soconusco chiapaneco

    OpenAIRE

    Lisbona Guillén, Miguel

    2015-01-01

    Referir la impronta dejada por los inmigrantes chinos que llegaron a Chiapas a finales del siglo XIX y principios del XX parece algo manido para quien conoce el estado y, muy especialmente, su región costera: el Soconusco. Sin embargo, lo obvio, por perceptible, como puede ser la existencia de una tradición gastronómica conocida como comida china, y convertida en marca de identidad en la región, no significa que la construcción de "lo chino" o de una "comunidad china" por parte de los hijos o...

  3. Tecidos moles (não resistentes: como se fossilizam?

    Directory of Open Access Journals (Sweden)

    Silvia Regina Gobbo

    2015-06-01

    Full Text Available A preservação de tecidos moles (não resistentes desperta atenção pela qualidade dos fósseis preservados, e pela raridade. Este trabalho faz ampla revisão do assunto, desfaz alguns dos mitos correntes sobre fossilização destes materiais, como anaerobiose e soterramento rápido, bem como assinala a relevância do papel da replicagem de estruturas morfológicas por colônias microbianas. No âmbito dos fatores que influenciam a preservação de tecidos não resistentes estão pH, processos de decomposição, soterramento rápido e mineralização rápida por meio de carbonatos ou fosfatos. É possível citar exemplos de fácies sedimentares nas quais há preservação de tecidos não resistentes, como os folhelhos pirobetuminosos, calcários litográficos, folhelhos e diatomitos. Destaca-se o papel das colônias microbianas, tanto na forma de microesferas, como aquelas não-esferulíticas. Os três mitos principais que se procurou desfazer no artigo são: (1 a presença de oxigênio; (2 o soterramento rápido e (3 as colônias microbianas.

  4. Pegada Hídrica como Indicador de Sustentabilidade Ambiental1

    Directory of Open Access Journals (Sweden)

    Kettrin Farias Bem Maracajá

    2012-08-01

    Full Text Available O conceito de pegada hídrica tem sido recentemente introduzido como um importante indicador do consumo de água humano, na tentativa de minimizar os impactos ambientais. Esse trabalho aborda o conceito da pegada hídrica como um indicador de sustentabilidade, com vistas o uso racional dos recursos hídricos. Nos últimos anos, a escassez de alguns recursos naturais vem sendo bastante discutido em todo o mundo e quanto à água a preocupação é ainda maior em face do uso desordenado na irrigação, bem como pela poluição da água potável através da indústria e agricultura. Partindo dessa análise, a pegada hídrica surge como um indicador de sustentabilidade da água doce em seus diferentes tipos de consumo para que seja utilizada de forma consciente. Com base na revisão da literatura sobre o tema abordado, conclui-se que para a redução da pegada hídrica se deve tomar medidas de controle do uso direto e indireto da água doce principalmente na agricultura irrigada.

  5. La dimensión cultural como catalizadora del desarrollo

    OpenAIRE

    Duque Escobar, Gonzalo

    2011-01-01

    Cuando se enuncia el desarrollo sostenible, se expresa en términos de tres pilares: el ecológico, el social y el económico, por lo que la cultura como campo que abarca a la ciencia, donde naturaleza y sociedad son variables culturales con relaciones dialécticas, siempre ha escapado.

  6. ECMO como puente a decisión

    Directory of Open Access Journals (Sweden)

    Charles E. Juvin-Bouvier

    2017-09-01

    La ECMO es una herramienta fundamental en el manejo del shock cardiogénico refractario para ganar tiempo con vistas a decidir una actitud definitiva pero puede condicionar situaciones de peligro vital como la hemorragia secundaria a la anticoagulación que requiere el dispositivo.

  7. La Evaluación como Medio de Aprendizaje

    Directory of Open Access Journals (Sweden)

    Camilo Díaz Rosero

    2017-12-01

    de 1992. Conclusiones: La educación superior al ser considerada como un servicio, reporta altas ganancias económicas y proliferación de instituciones de dudosa calidad, por lo que el Gobierno debe estar atento y ser más riguroso en su regulación.

  8. Tuberculosis como enfermedad ocupacional Tuberculosis as occupational disease

    Directory of Open Access Journals (Sweden)

    Alberto Mendoza-Ticona

    2012-06-01

    Full Text Available Existe evidencia suficiente para declarar a la tuberculosis como enfermedad ocupacional en diversos profesionales especialmente entre los trabajadores de salud. En el Perú están normados y reglamentados los derechos laborales inherentes a la tuberculosis como enfermedad ocupacional, como la cobertura por discapacidad temporal o permanente. Sin embargo, estos derechos aún no han sido suficientemente socializados. En este trabajo se presenta información sobre el riesgo de adquirir tuberculosis en el lugar de trabajo, se revisan las evidencias para declarar a la tuberculosis como enfermedad ocupacional en trabajadores de salud y se presenta la legislación peruana vigente al respecto.There is enough evidence to declare tuberculosis as an occupational disease among healthcare workers. In Peru, there are regulations granting employment rights regarding tuberculosis as an occupational disease, such as healthcare coverage for temporary or permanent disability. However, these rights have not been sufficiently socialized. This study presents information on the risk of acquiring tuberculosis in the workplace, and a review of the evidence to declare tuberculosis as an occupational disease among health care workers, presenting the current Peruvian law related.

  9. Limitaciones del IMC como indicador exclusivo de estado nutricional

    Directory of Open Access Journals (Sweden)

    Moreno Romero, Susana

    2007-01-01

    Full Text Available El presente trabajo tiene como objetivo determinar el potencial diagnóstico y las limitaciones del uso del Índice de Masa Corporal como único indicador del estado nutricional. Para ello se analizó una muestra constituida por 2155 sujetos de ambos sexos, con edades comprendidas entre los 6 y 18 años y pertenecientes a tres poblaciones jujeñas que difieren en ubicación altitudinal y nivel socieconómico (NSE: 1. Susques, localidad rural situada a 3675 m.s.n.m; 2. Alto Comedero, barrio periférico de San Salvador de Jujuy (1250 m.s.n.m. de NSE bajo; y 3. José Hernández, muestra representativa del estrato SE elevado de la misma capital. Se tomaron las medidas directas de talla, peso, perímetro braquial y pliegues de grasa subcutánea tricipital y subescapular, entre otras. A partir de éstas, se calculó el IMC y las áreas tisulares del brazo. Se establecieron las categorías nutricionales en función de los percentilos establecidos por el NHANES I y II para la talla, IMC, área magra y grasa del brazo y pliegues tricipital y subescapular. Al comparar los resultados obtenidos para cada variable se comprueba como el uso exclusivo del IMC enmascara importantes patologías nutricionales, tanto por defecto como por exceso.

  10. El etanol como materia prima petroquímica

    Directory of Open Access Journals (Sweden)

    Luis M. Carballo

    1981-07-01

    Full Text Available En este trabajo se presentan los aspectos relevantes de un programa a de investigación, aprobado por el CINDEC y COLCIENCIAS, sobre el desarrollo y estudio cinético de catalizadores para algunas reacciones químicas en las que el etanol está involucrado como reactante.

  11. Procalcitonina como marcador de sepsis en niños

    Directory of Open Access Journals (Sweden)

    Diana González Rangel

    2016-04-01

    Conclusión. La procalcitonina tiene un buen rendimiento diagnóstico como marcador de sepsis en niños —con mayor utilidad cuando toma valores negativos— y buen valor pronóstico al relacionarse con mortalidad.

  12. Diagnostic significance of tumor markers CEA, CA50 and CA19-9 for colorectal cancer

    International Nuclear Information System (INIS)

    Chen Yumei; Huang Gang

    2005-01-01

    Objective: To investigate the expression and diagnostic significance of three serum tumor markers (CEA, CA50, CA19-9) in patients with colorectal cancer, with special emphasis on their combined assay. Methods: Serum CEA, CA19-9 levels (with chemiluminescence immunoassay) and CA50 levels (with immunoradiometric assay) were determined in 94 patients with colorectal cancer, 20 patients with benign colorectal disorders and 37 controls. Results: The expressions of the serum tumor markers were significantly higher in patients with colorectal cancer than those in patients with benign colorectal disorders and controls (P<0.05). There was no significant difference between the levels in the latter two groups. CEA assay had the highest sensitivity (57.4%) and specificity (85.9%). Combined assay of the three could enhance both the sensitivity (62.7%) and specificity (96.5%). The serum levels of the markers were significantly higher in patients with colonic cancer than those in patients with rectal cancer (P<0.05). The levels were positively correlated with the size of the growth and stage of the disease. Serum tumor marker levels were also significantly higher in patients with metastasis (regional/distant) than those in patients without metastasis (P<0.05). Conclusion: Determination of serum CEA, CA50 and CA19-9 levels had definite value for the diagnosis and assessment of the pathology as well as biologic behavior colorectal cancer. Combined assay of the three could enhance the diagnostic sensitivity and specificity. (authors)

  13. Radiolysis of Ca14CO3

    International Nuclear Information System (INIS)

    Sanchez, M.G.A.

    1986-01-01

    The partition-ion exclusion chromatography is evaluated to analyse non-ionic organic compounds obtained from radiolysis of high specific activity Ca 14 CO 3 . The Ca 14 CO 3 was irradiated by β - decay of carbon-14 or by γ rays from a cobalt-60 source. The crystals were dissolved for qualitative and quantitative analysis of the radiolytic products. Formic and oxalic acids were produced in high yields. Glyoxylic, acetic and glycolic acids, formaldehyde and methanol were produced in low yields. Quantitative determination was carried out by liquid scintillation spectroscopy and the chemical yields (G-values) were calculated for the products. Mechanisms of product formation are proposed based on thermal annealing experiments. (Author) [pt

  14. Clustering and triaxial deformations of 40Ca

    International Nuclear Information System (INIS)

    Taniguchi, Yasutaka; Kimura, Masaaki; Kanada-En'yo, Yoshiko; Horiuchi, Hisashi

    2007-01-01

    We have studied the positive-parity states of 40 Ca using antisymmetrized molecular dynamics (AMD) and the generator coordinate method (GCM). Imposing two different kinds of constraints on the variational calculation, we have found various kinds of 40 Ca structures such as a deformed-shell structure, as well as α- 36 Ar and 12 C- 28 Si cluster structures. After the GCM calculation, we obtained a normal-deformed band and a superdeformed band together with their side bands associated with triaxial deformation. The calculated B(E2) values agreed well with empirical data. It was also found that the normal-deformed and superdeformed bands have non-negligible α- 36 Ar cluster and 12 C- 28 Si cluster components, respectively. This leads to the presence of an α- 36 Ar higher nodal band occurring above the normal-deformed band

  15. El proyecto Wiki Learning: Wikipedia como entorno de aprendizaje abierto

    Directory of Open Access Journals (Sweden)

    2016-10-01

    Full Text Available Los enfoques predominantes en el sistema educativo tradicional circunscriben las posibilidades de aprendizaje a entornos formales y cerrados. Sin embargo, las tecnologías móviles y plataformas digitales están transformando este paradigma, expandiendo las posibilidades de aprendizaje. A partir de esta condición y en el marco de la producción del conocimiento entre pares, sostenemos que Wikipedia puede ser utilizada como un entorno de aprendizaje abierto que cumple varios propósitos: a permite adquirir competencias básicas; b contribuye a la inteligencia colectiva; c acorta la brecha global de conocimiento; y, d facilita la construcción de redes globales de aprendizaje. Este estudio de caso tiene como objetivo presentar el proceso, estrategias y resultados del proyecto Wiki Learning, como modelo de aprendizaje abierto a través del uso de Wikipedia en una universidad mexicana. El proyecto abarcó desde la producción de artículos hasta talleres para el desarrollo de capacidades de profesores y estudiantes. Se realizaron encuestas a 57 docentes y 115 alumnos para identificar la percepción acerca de Wikipedia, su uso y posibilidades como herramienta educativa. Los resultados demostraron que a pesar de que todos son usuarios de Wikipedia, existe un desconocimiento general sobre su funcionamiento, estructura y comunidades, además de cierta desconfianza. Se presenta un desafío para romper el estigma y recuperar el valor de la gestión compartida del conocimiento, el propósito de la enciclopedia y su lugar como producto de la inteligencia colectiva.

  16. O jogo como ferramenta de ensino e aprendizagem em fonoaudiologia

    Directory of Open Access Journals (Sweden)

    Kelly da Silva

    2018-03-01

    Full Text Available Objetivo: descrever a percepção de discentes sobre a utilização da estratégia do jogo detetive em metodologias ativas para revisão de conteúdo. Método: 22 discentes de ambos os sexos e com média de 23 anos participaram de um jogo de tabuleiro como recurso didático-pedagógico para revisão de conteúdo de um módulo teórico-prático de um curso de graduação em Fonoaudiologia, sobre o tema Linguagem no adulto e idoso. Questões conceituais e casos clínicos foram apresentados para a resolução dos participantes, para que pudessem integrar a teoria com a prática clínica. Os participantes responderam a uma questão norteadora sobre a dinâmica proposta e os resultados foram tratados com técnica de Análise de Conteúdo. Resultados: a estratégia foi descrita como uma intervenção dinâmica, que se opõe ao modelo não participativo, sendo considerada como de eficiência consistente e significativa para a revisão do conteúdo almejado, como favorecedora para a construção do conhecimento coletivo e adequado ao propósito do módulo. Conclusão: as respostas obtidas evidenciaram a percepção positiva dos discentes da pesquisa quanto à utilização do jogo “Detetive da Linguagem” como método de ensino e aprendizagem.

  17. La agrobiodiversidad como elemento de la seguridad alimentaria y ambiental

    Directory of Open Access Journals (Sweden)

    De la Rosa Fernández, Lucía

    2016-06-01

    Full Text Available In this article, the importance and situation of the conservation of plant genetic resources for food and agriculture is reviewed, taking into consideration not only the aspects specifically related to the conservation activity but also their role as components of biodiversity and providers of ecosystem services. Special attention is drawn to ex situ collections as providers of germplasm for direct use and for plant breeding, two elements that make an essential contribution to a greater resilience of agriculture to environmental changes. In particular, the state of conservation at national and global levels of genetic resources of Fabaceae species cultivated for human food and animal feed, is examined.En el artículo se revisa la importancia y la situación de la conservación de recursos fitogenéticos para la alimentación y la agricultura, tanto en los aspectos asociados específicamente a esta actividad como en aquellos otros derivados de su faceta como componente de la biodiversidad y proveedor de servicios ecosistémicos. Se incide en la función de las colecciones ex situ como fuente de materiales tanto para su utilización directa como en programas de mejora genética, ambos elementos imprescindibles para una agricultura resiliente frente al cambio ambiental. De forma específica, se describe el estado de la conservación de germoplasma de las especies de la familia de Fabaceae tanto para utilización en alimentación humana como en alimentación animal, en el ámbito nacional e internacional.

  18. Astrocyte Ca2+ signalling: an unexpected complexity

    OpenAIRE

    Volterra, Andrea; Liaudet, Nicolas; Savtchouk, Iaroslav

    2014-01-01

    Astrocyte Ca(2+) signalling has been proposed to link neuronal information in different spatial-temporal dimensions to achieve a higher level of brain integration. However, some discrepancies in the results of recent studies challenge this view and highlight key insufficiencies in our current understanding. In parallel, new experimental approaches that enable the study of astrocyte physiology at higher spatial-temporal resolution in intact brain preparations are beginning to reveal an unexpec...

  19. 43Ca NMR in solid state

    Science.gov (United States)

    Bellot, P.-V.; Trokiner, A.; Zhdanov, Yu.; Yakubovskii, A.

    1998-02-01

    In this paper we show that 43Ca is a suitable NMR probe to study the properties of high-Tc superconducting oxides. In the normal state, we report the temperature and doping dependencies of the spin susceptibility measured by 43Ca NMR. In the superconducting state and more exactly in the mixed state, by analysing 43Ca NMR linewidth, we have studied the magnetic induction distribution due to the presence of vortices and deduced λ, the penetration depth. Dans cet article, on montre que l'isotope 43 du calcium est une bonne sonde RMN pour l'étude des propriétés des oxydes supraconducteurs à haute température. Dans l'état normal, par la détermination du déplacement de la raie, en fonction de la température, on accède à la variation thermique de la susceptibilité de spin. Dans l'état supraconducteur et plus particulièrement dans l'état mixte, la largeur de raie RMN permet d'étudier la distribution d'induction magnétique due à la présence des vortex et de déterminer λ, la longueur de pénétration.

  20. Mg,Ca-ATPase activity under irradiation

    International Nuclear Information System (INIS)

    Ladutin, V.V.; Orlova, V.V.; Lob, P.A.; Gerasiminko, I.V.; Mack, E.I.

    2003-01-01

    Full text: The influence of different doses irradiation at the Mg,Ca-ATPase activity at the rat brain has been investigated. The analyses were made at the apparatus of LKB and Carl-Ceis-Jena firm with help of reagents of Sigma and Boehringer firm. Rats decapitated after 1, 3, 6, 24 and 48 h after action of irradiation. Dose 0.206 C/kg. Erythrocytes. 1 and 3h after irradiation influence- decrease of Mg,Ca-ATPase activity to 86-87% relatively control level, 24 and 48 h - increase of activity to the control level. Dose 0.312 C/kg. Large hemispheres. 1h - decrease of ATPase activity to 90% relatively control, 3h - increase to control level, 24h - fall to 86%, after 48h small increase to 93% relatively control. Dose 9.287 C/kg. Large hemispheres. 1h - sharp fall of Mg, Ca-ATPase activity to 67 % relatively control, increase of activity to 96% after 3h and sharp fall of activity to 64% 6h after action of irradiation. Dose 9.287 C/kg. Cerebellum. 1h - sharp decrease of ATPase activity to 80%. After 3h -sharp increase to 160% relatively control level and sharp fall of ATPase activity to 47% relatively control after 6h. The mechanism of radiation pathology of active ion transport has been discussed

  1. Ca-48 targets - Home and abroad!

    Science.gov (United States)

    Greene, John P.; Carpenter, Michael; Janssens, Robert V. F.

    2018-05-01

    Using the method of reduction/distillation, high-purity films of robust and ductile calcium metal were prepared for use as targets in nuclear physics experiments. These targets, however, are extremely air-sensitive and procedures must be developed for their handling and use without exposure to the air. In most instances, the thin 48Ca target is used on a carrier foil (backing) and a thin covering film of similar material is employed to further reduce re-oxidation. Un-backed metallic targets are rarely produced due to these concerns. In addition, the low natural abundance of the isotope 48Ca provided an increased incentive for the best efficiencies available in their preparation. Here, we describe the preparation of 48Ca targets employing a gold backing and thin gold cover for use at home, Argonne National Laboratory (ANL), as well as abroad, at Osaka University. For the overseas shipments, much care and preparation were necessary to ensure good targets and safe arrival to the experimental facilities.

  2. Glucagon releases Ca2+ from a FCCP-sensitive pool

    International Nuclear Information System (INIS)

    Kraus-Friedmann, N.

    1986-01-01

    The effects of physiological levels of glucagon on Ca 2+ efflux were examined in the perfused rat liver. Two methods were used to estimate Ca 2+ efflux: (1) prior labeling of the Ca 2+ pools with 45 Ca 2+ , and (2) measurement of perfusate Ca 2+ with atomic absorption. According to both methods, glucagon administration at the physiological level evoked Ca 2+ release. In order to identify the hormone-sensitive Ca 2+ pool, a method employed by several laboratories was used. In this method, mitochondrial Ca 2+ is released by FCCP, (carbonyl-cyanide 4 (trifluoro/methoxy) phenylhydrazone), a mitochondrial uncoupler. The effect of hormones on Ca 2+ release after such uncoupler administration is measured. A decreased release is taken as an indication that the pool is entirely or partially mitochondrial. FCCP released 90 +/- 29 nmoles Ca 2+ /gr wet liver. Glucagon (5 x 10 -9 M) released 107 +/- 45 nmoles Ca 2+ /gr wet liver before and 26 +/- 9 nmoles Ca 2+ /gr wet liver after FCCP. These data indicate that glucagon releases Ca 2+ mostly from the mitochondria

  3. CaMKII in sinoatrial node physiology and dysfunction

    Directory of Open Access Journals (Sweden)

    Yuejin eWu

    2014-03-01

    Full Text Available The calcium and calmodulin dependent protein kinase II (CaMKII is present in sinoatrial node (SAN pacemaker cells and is required for physiological fight or flight SAN beating rate responses. Inhibition of CaMKII in SAN does not affect baseline heart rate, but reduces heart rate increases in response to physiological stress. CaMKII senses intracellular calcium (Ca2+ changes, oxidation status and hyperglycemia to phosphorylate substrates that regulate Ca2+-sensitive proteins, such as L-type Ca2+ channels, phospholamban (PLN, and cardiac ryanodine receptors (RyR2. All of these substrates are involved in the SAN pacemaking mechanism. Excessive CaMKII activity, as occurs under pathological conditions such as heart failure, ischemia and diabetes, can promote intracellular Ca2+ overload and reactive oxygen species (ROS production. Oxidation of CaMKII (ox-CaMKII locks CaMKII into a constitutively active configuration that contributes to SAN cell apoptosis and fibrosis. This ox-CaMKII-mediated loss of functional SAN cells contributes to sinoatrial node dysfunction (SND and sudden death. Thus, CaMKII has emerged as a central regulator of physiological SAN responses and a key determinant of SND.

  4. IP3 stimulates CA++ efflux from fusogenic carrot protoplasts

    International Nuclear Information System (INIS)

    Rincon, M.; Boss, W.F.

    1986-01-01

    Polyphosphoinositide breakdown plays an important role in signal transduction in animal cells (Berridge and Irvine, 1984, Nature, 312:315). Upon stimulation, phospholipase C hydrolyzes phosphatidylinositol 4,5-bisphosphate to inositol 1,4,5-trisphosphate (IP 3 ) and diacylglycerol both of which act as cellular second messengers. IP 3 mobilizes Ca ++ from internal stores, hence the cytosolic free Ca ++ concentration increases and those physiological activities regulated by Ca ++ are stimulated. To test if plant cells also responded to IP 3 , Ca ++ efflux studies were done with fusogenic carrot protoplasts released in EGTA. The protoplasts were preloaded with 45 Ca ++ placed in a Ca ++ -free medium, and efflux determined as 45 Ca ++ loss from the protoplasts. IP 3 (10-20μM) caused enhanced 45 Ca ++ efflux and the response was sustained for at least 15 min. In plants, as in animals, the observed IP 3 -enhanced 45 Ca ++ efflux suggested that IP 3 released Ca ++ from internal stores, and the increased free cytosolic Ca ++ activated Ca ++ pumping mechanisms which restored the Ca ++ concentration in the cytosol to the normal level

  5. The CaV2.3 R-type voltage-gated Ca2+ channel in mouse sleep architecture.

    Science.gov (United States)

    Siwek, Magdalena Elisabeth; Müller, Ralf; Henseler, Christina; Broich, Karl; Papazoglou, Anna; Weiergräber, Marco

    2014-05-01

    Voltage-gated Ca(2+) channels (VGCCs) are key elements in mediating thalamocortical rhythmicity. Low-voltage activated (LVA) CaV 3 T-type Ca(2+) channels have been related to thalamic rebound burst firing and to generation of non-rapid eye movement (NREM) sleep. High-voltage activated (HVA) CaV 1 L-type Ca(2+) channels, on the opposite, favor the tonic mode of action associated with higher levels of vigilance. However, the role of the HVA Non-L-type CaV2.3 Ca(2+) channels, which are predominantly expressed in the reticular thalamic nucleus (RTN), still remains unclear. Recently, CaV2.3(-/-) mice were reported to exhibit altered spike-wave discharge (SWD)/absence seizure susceptibility supported by the observation that CaV2.3 mediated Ca(2+) influx into RTN neurons can trigger small-conductance Ca(2+)-activated K(+)-channel type 2 (SK2) currents capable of maintaining thalamic burst activity. Based on these studies we investigated the role of CaV2.3 R-type Ca(2+) channels in rodent sleep. The role of CaV2.3 Ca(2+) channels was analyzed in CaV2.3(-/-) mice and controls in both spontaneous and artificial urethane-induced sleep, using implantable video-EEG radiotelemetry. Data were analyzed for alterations in sleep architecture using sleep staging software and time-frequency analysis. CaV2.3 deficient mice exhibited reduced wake duration and increased slow-wave sleep (SWS). Whereas mean sleep stage durations remained unchanged, the total number of SWS epochs was increased in CaV2.3(-/-) mice. Additional changes were observed for sleep stage transitions and EEG amplitudes. Furthermore, urethane-induced SWS mimicked spontaneous sleep results obtained from CaV2.3 deficient mice. Quantitative Real-time PCR did not reveal changes in thalamic CaV3 T-type Ca(2+) channel expression. The detailed mechanisms of SWS increase in CaV2.3(-/-) mice remain to be determined. Low-voltage activated CaV2.3 R-type Ca(2+) channels in the thalamocortical loop and extra

  6. Is tissue CA125 expression in epithelial ovarian adenocarcinoma heterogenic?

    DEFF Research Database (Denmark)

    Sparholt, Morten H; Høgdall, Claus K; Nedergaard, Lotte

    2013-01-01

    To evaluate if heterogeneity of tissue cancer antigen 125 (CA125) expression is present in epithelial serous adenocarcinomas. Furthermore, to investigate whether there is a correlation between levels of CA125 tissue expression, serum level of CA125, stage, and grade. A total of 10 patients...... diagnosed with serous ovarian adenocarcinomas were included. Preoperative blood samples were collected to determine serum CA125 levels. Tumor tissue from primary surgery was collected and processed for immunohistochemical analyses. CA125 was expressed in varying degrees in tumor tissues from all patients....... Mean tissue CA125 expression for each patient ranged from 36% to 98%. Intrapatient variations in tissue expression ranged from 10% to 90% point. No significant correlations between levels of CA125 tissue expression, serum level of CA125, stage, and grade were found. We found that the tissue expression...

  7. Characterization of Bacillus subtilis YfkE (ChaA): a calcium-specific Ca2+/H+ antiporter of the CaCA family.

    Science.gov (United States)

    Fujisawa, Makoto; Wada, Yuko; Tsuchiya, Takahiro; Ito, Masahiro

    2009-08-01

    YfkE, a protein from Bacillus subtilis, exhibits homology to the Ca(2+):Cation Antiporter (CaCA) Family. In a fluorescence-based assay of everted membrane vesicles prepared from Na(+)(Ca(2+))/H(+) antiporter-defective mutant Escherichia coli KNabc, YfkE exhibited robust Ca(2+)/H(+) antiport activity, with a K (m) for Ca(2+) estimated at 12.5 muM at pH 8.5 and 113 muM at pH 7.5. Neither Na(+) nor K(+) served as a substrate. Mg(2+) also did not serve as a substrate, but inhibited the Ca(2+)/H(+) antiporter activity. The Ca(2+) transport capability of YfkE was also observed directly by transport assays in everted membrane vesicles using radiolabeled (45)Ca(2+). Transcriptional analysis from the putative yfkED operon using beta-garactosidase activity as a reporter revealed that both of the yfkE and yfkD genes are regulated by forespore-specific sigma factor, SigG, and the general stress response regulator, SigB. These results suggest that YfkE may be needed for Ca(2+) signaling in the sporulation or germination process in B. subtilis. ChaA is proposed as the designation for YfkE of B. subtilis.

  8. MicroRNA-145 suppresses ROS-induced Ca2+ overload of cardiomyocytes by targeting CaMKIIδ

    International Nuclear Information System (INIS)

    Cha, Min-Ji; Jang, Jin-Kyung; Ham, Onju; Song, Byeong-Wook; Lee, Se-Yeon; Lee, Chang Yeon; Park, Jun-Hee; Lee, Jiyun; Seo, Hyang-Hee; Choi, Eunhyun; Jeon, Woo-min; Hwang, Hye Jin; Shin, Hyun-Taek

    2013-01-01

    Highlights: •CaMKIIδ mediates H 2 O 2 -induced Ca 2+ overload in cardiomyocytes. •miR-145 can inhibit Ca 2+ overload. •A luciferase assay confirms that miR-145 functions as a CaMKIIδ-targeting miRNA. •Overexpression of miR-145 regulates CaMKIIδ-related genes and ameliorates apoptosis. -- Abstract: A change in intracellular free calcium (Ca 2+ ) is a common signaling mechanism of reperfusion-induced cardiomyocyte death. Calcium/calmodulin dependent protein kinase II (CaMKII) is a critical regulator of Ca 2+ signaling and mediates signaling pathways responsible for functions in the heart including hypertrophy, apoptosis, arrhythmia, and heart disease. MicroRNAs (miRNA) are involved in the regulation of cell response, including survival, proliferation, apoptosis, and development. However, the roles of miRNAs in Ca 2+ -mediated apoptosis of cardiomyocytes are uncertain. Here, we determined the potential role of miRNA in the regulation of CaMKII dependent apoptosis and explored its underlying mechanism. To determine the potential roles of miRNAs in H 2 O 2 -mediated Ca 2+ overload, we selected and tested 6 putative miRNAs that targeted CaMKIIδ, and showed that miR-145 represses CaMKIIδ protein expression and Ca 2+ overload. We confirmed CaMKIIδ as a direct downstream target of miR-145. Furthermore, miR-145 regulates Ca 2+ -related signals and ameliorates apoptosis. This study demonstrates that miR-145 regulates reactive oxygen species (ROS)-induced Ca 2+ overload in cardiomyocytes. Thus, miR-145 affects ROS-mediated gene regulation and cellular injury responses

  9. MicroRNA-145 suppresses ROS-induced Ca{sup 2+} overload of cardiomyocytes by targeting CaMKIIδ

    Energy Technology Data Exchange (ETDEWEB)

    Cha, Min-Ji [Cardiovascular Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Jang, Jin-Kyung [College of Pharmacy, Sookmyung Women’s University, 52 HyoChangWon-Gil, Yongsan-ku, Seoul 140-742 (Korea, Republic of); Ham, Onju; Song, Byeong-Wook; Lee, Se-Yeon [Cardiovascular Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Lee, Chang Yeon; Park, Jun-Hee [Department of Integrated Omics for Biomedical Sciences, Graduate School, Yonsei University, 50 Yonsei-ro, Seodamun-gu, Seoul 120-759 (Korea, Republic of); Lee, Jiyun; Seo, Hyang-Hee [Cardiovascular Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Choi, Eunhyun [Severance Integrative Research Institute for Cerebral and Cardiovascular Disease, Yonsei University Health System, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Jeon, Woo-min [Department of Animal Resource, Sahmyook University, Seoul 139-742 (Korea, Republic of); Hwang, Hye Jin [Cardiovascular Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Shin, Hyun-Taek [College of Pharmacy, Sookmyung Women’s University, 52 HyoChangWon-Gil, Yongsan-ku, Seoul 140-742 (Korea, Republic of); and others

    2013-06-14

    Highlights: •CaMKIIδ mediates H{sub 2}O{sub 2}-induced Ca{sup 2+} overload in cardiomyocytes. •miR-145 can inhibit Ca{sup 2+} overload. •A luciferase assay confirms that miR-145 functions as a CaMKIIδ-targeting miRNA. •Overexpression of miR-145 regulates CaMKIIδ-related genes and ameliorates apoptosis. -- Abstract: A change in intracellular free calcium (Ca{sup 2+}) is a common signaling mechanism of reperfusion-induced cardiomyocyte death. Calcium/calmodulin dependent protein kinase II (CaMKII) is a critical regulator of Ca{sup 2+} signaling and mediates signaling pathways responsible for functions in the heart including hypertrophy, apoptosis, arrhythmia, and heart disease. MicroRNAs (miRNA) are involved in the regulation of cell response, including survival, proliferation, apoptosis, and development. However, the roles of miRNAs in Ca{sup 2+}-mediated apoptosis of cardiomyocytes are uncertain. Here, we determined the potential role of miRNA in the regulation of CaMKII dependent apoptosis and explored its underlying mechanism. To determine the potential roles of miRNAs in H{sub 2}O{sub 2}-mediated Ca{sup 2+} overload, we selected and tested 6 putative miRNAs that targeted CaMKIIδ, and showed that miR-145 represses CaMKIIδ protein expression and Ca{sup 2+} overload. We confirmed CaMKIIδ as a direct downstream target of miR-145. Furthermore, miR-145 regulates Ca{sup 2+}-related signals and ameliorates apoptosis. This study demonstrates that miR-145 regulates reactive oxygen species (ROS)-induced Ca{sup 2+} overload in cardiomyocytes. Thus, miR-145 affects ROS-mediated gene regulation and cellular injury responses.

  10. Polyamines mediate abnormal Ca2+ transport and Ca2+-induced cardiac cell injury in the calcium paradox

    International Nuclear Information System (INIS)

    Trout, J.J.; Koenig, H.; Goldstone, A.D.; Lu, C.Y.; Fan, C.C.

    1986-01-01

    Ca 2+ -free perfusion renders heart cells Ca 2+ -sensitive so that readmission of Ca 2+ causes a sudden massive cellular injury attributed to abnormal entry of Ca 2+ into cells (Ca paradox). Hormonal stimulation of Ca 2+ fluxes was earlier shown to be mediated by polyamines (PA). 5 min perfusion of rat heart with Ca 2+ -free medium induce a prompt 40-50% decline in levels of the PA putrescine (PUT), spermidine and spermine and their rate-regulatory synthetic enzyme ornithine decarboxylase (ODC), and readmission of Ca 2+ -containing medium abruptly ( 2+ reperfusion-induced increases in ODC and PA and also prevented increased 45 Ca 2+ uptake and heart injury, manifested by loss of contractility, release of enzymes (CPK, LDH), myoglobin and protein, and E.M. lesions (contracture bands, mitochondrial changes). 1 mM PUT negated DFMO inhibition, repleted heart PA and restored Ca 2+ reperfusion-induced 45 Ca 2+ influx and cell injury. These data indicate that the Ca 2+ -directed depletion-repletion cycle of ODC and PA triggers excessive transsarcolemmal Ca 2+ transport leading to the calcium paradox

  11. Efectividad de las actividades enfermeras en la prevención de caídas en el anciano no hospitalizado

    OpenAIRE

    González López, Judit

    2016-01-01

    Objetivo: Identificar las actividades de la intervención NIC “prevención de caídas” en el adulto mayor de 65 años no hospitalizado para evitar las mismas. Método: Se revisaron estudios publicados en los últimos diez años que analizaban los factores de riesgo en las caídas así como la eficacia de las actividades para su prevención. Las bases de datos consultadas fueron Pubmed, SciELO, Cochrane plus y LILACS. Resultados: De 168 publicaciones se seleccionaron 24 que cumplían los c...

  12. Cannabinoids disrupt memory encoding by functionally isolating hippocampal CA1 from CA3.

    Directory of Open Access Journals (Sweden)

    Roman A Sandler

    2017-07-01

    Full Text Available Much of the research on cannabinoids (CBs has focused on their effects at the molecular and synaptic level. However, the effects of CBs on the dynamics of neural circuits remains poorly understood. This study aims to disentangle the effects of CBs on the functional dynamics of the hippocampal Schaffer collateral synapse by using data-driven nonparametric modeling. Multi-unit activity was recorded from rats doing an working memory task in control sessions and under the influence of exogenously administered tetrahydrocannabinol (THC, the primary CB found in marijuana. It was found that THC left firing rate unaltered and only slightly reduced theta oscillations. Multivariate autoregressive models, estimated from spontaneous spiking activity, were then used to describe the dynamical transformation from CA3 to CA1. They revealed that THC served to functionally isolate CA1 from CA3 by reducing feedforward excitation and theta information flow. The functional isolation was compensated by increased feedback excitation within CA1, thus leading to unaltered firing rates. Finally, both of these effects were shown to be correlated with memory impairments in the working memory task. By elucidating the circuit mechanisms of CBs, these results help close the gap in knowledge between the cellular and behavioral effects of CBs.

  13. La velocidad del cambio tecnológico empresarial como estrategia para sobrevivir

    Directory of Open Access Journals (Sweden)

    Alberto Garcia Arango

    2005-01-01

    Full Text Available Encontrar un modelo que facilite el cambio estratégico de una empresa, teniendo en cuenta la ubicación sectorial dentro del ciclo de cambios estructurales y así poder modificar la velocidad de cambio para mantenerse dentro del sector y para tomar decisiones sobre estrategia tecnológica, innovación y competencia. Para ello, se realiza una síntesis histórica del sector para ubicarlo en el ciclo estructural (Fine compuesto por los estados modular, poder del proveedor, infraestructura propia, integración, competencia en nicho y complejidad organizacional. Posteriormente, se determina el estado de una empresa sobre el patrón estructural y se mide su velocidad de cambio actual para recomendar la decisión sobre el grado de innovación tecnológica requerida para mantenerse dentro del patrón de cambio sectorial. Se identificaron los factores que inciden en la velocidad de cambio empresarial (frescura línea de productos, vida de catálogo del producto o servicio y porcentaje de caída precios de los insumos y se propuso el diseño de una estrategia expresada como cadena de valor, validada con una empresa colombiana que compite en sector de telecomunicaciones de los Estados Unidos.

  14. LA INTELIGENCIA COMO CAMPO DE ACCION DE LA PEDAGOGIA

    Directory of Open Access Journals (Sweden)

    Servio Tulio Salazar Valencia

    2000-05-01

    Full Text Available Si la inteligencia se concibe como un conjunto de habilidades de pensamiento y de aprendizaje, utilizados para solucionar problemas tanto académicos como de la cotidianidad, constituye ésta un centro de especial interés para quienes hemos asumido la delicada tarea de intentar formar, y si es posible, transformar las conductas de las juventudes estudiosas de nuestro país. En el presente ensayo se critican algunos comportamientos de los docentes que, esconociendo que la inteligencia "es una extensión de algunas características biológicas fundamentales del ser" (Piaget, pretenden poseer una metodología única e irrefutable en su labor pedagógica.

  15. Os eventos programados, como alternativo do desenvolvimento do turismo

    Directory of Open Access Journals (Sweden)

    Andrés Pinassi

    2014-10-01

    Full Text Available Turismo e lazer são vistos como uma alternativa para o desenvolvimento econômico, social e cultural de uma comunidade. Ambas práticas de lazer são consolidadas como processos sócio-espaciais que podem trazer muitos impactos benéficos para os moradores de uma determinada localidade. Assim, a dinâmica de eventos programados em aldeias visa proporcionar uma alternativa oportunidades de desenvolvimento local para comunidades carentes. Nesse contexto, a pesquisa desenvolvida, em seguida, analisa o desenvolvimento de um festival especial, realizada na Provincia de Buenos Aires (Argentina. Este festival, iniciado a partir da esfera pública municipal, mostrou benefícios económicos significativos e definir um entretenimento alternativa valiosa para a população local e da área de influência.

  16. La docencia como práctica profesional

    Directory of Open Access Journals (Sweden)

    Martínez de Acosta Carmen H.

    1993-12-01

    Full Text Available

    No es fácil determinar si la actividad docente corresponde o no a una modalidad de práctica, rol, área de desempeño o ejercicio profesional como indiscriminadamente se denomina a las diferentes formas del quehacer de enfermería. Uno de los conceptos básicos de sociología es el de rol. El rol consiste en las conductas cumplidas o conductas percibidas como aceptables, referidas a una situación dada. La identificación de un rol se alcanza por medio de un proceso mutuo de validación y socialización profesional.

  17. La radio como expresión libre del Aymara.

    Directory of Open Access Journals (Sweden)

    Nestor Hugo Quiroga

    2015-05-01

    Full Text Available En el campo de los principios teóricos sobre las posibilidades educativas de la radio, es indispensable precisar algunos conceptos fundamentales como: una pedagogía de la expresión y de la comunicación; una pedagogía integral; y los sistemas abiertos de comunicación. La siguiente etapa, dentro de este análisis, es la aplicación de estos principios fundamentales a la tarea concreta de crear un sistema abierto que procese y genere intercomunicación (que, por tanto, eduque y autoeduque, en un ambiente definible como la vasta comunidad aymara, a través de un subsistema comunicador específico llamado radio.

  18. Octadecanoides como reguladores de la defensa de las plantas

    Directory of Open Access Journals (Sweden)

    G. Camarena Gutiérrez

    2002-01-01

    Full Text Available En años recientes muchas moléculas lipoides muy potentes han sido identificadas, comprenden compuestos lipofílicos no derivados de lípidos como los brasinoesteroides triterpenoides, otros que parcialmente son de origen lipídico como los lipo-oligosacáridos, factores de nodulación de especies de Rhizobium que pueden tener parientes endógenos en las plantas, y un tercer grupo, los octadecanoides, cuyas estructuras son derivadas de ácidos grasos vegetales. Las señales mediadas por lípidos son un aspecto importante de la vida de las plantas y un área de investigación en rápido crecimiento.

  19. El derecho como modelo para las ciencias naturales

    Directory of Open Access Journals (Sweden)

    Vittorio Villa

    2005-12-01

    Full Text Available El artículo comienza con una exposición del modo tradicional de entender, durante siglos, la relación entre ciencia jurídica y ciencias naturales. Describe después el cambio radical del contexto epistemológico de fondo que se ha producido en las últimas cuatro décadas. Expone luego cómo, dentro de ese cambio, va apareciendo el derecho como modelo para las ciencias naturales, en fuerza de dos tipos diversos de analogía entre el derecho y esas ciencias. La última parte está dedicada a proponer la concepción del autor sobre las razones de la elección del derecho como modelo

  20. Las directrices del costo como fuentes de ventajas competitivas.

    Directory of Open Access Journals (Sweden)

    José Reinel Bermeo Muñoz

    2005-01-01

    Full Text Available Este trabajo pretende describir con el mayor detalle y actualización posible el comportamiento de los costos dentro de una actividad de valor con base en los diez factores estructurales que influyen en el costo, denominados por Michael E. Porter (1985, como guías o directrices del costo en su libro La Ventaja Competitiva. Estas directrices actúan como fuentes directas para establecer y sostener el posicionamiento estratégico asumido por la empresa, para determinar la posición relativa de costos y para explicar, en gran parte, la generación temporal de valor en las diversas actividades desarrolladas a lo largo de la cadena de valor. Por esto constituyen uno de los fundamentos para explicar las diferencias de resultados entre empresas pertenecientes al mismo sector de actividad económica y fuentes de ventajas competitivas sostenibles.

  1. LA BIOÉTICA COMO QUEHACER FILOSÓFICO

    Science.gov (United States)

    Ferrer, Jorge José

    2009-01-01

    El artículo examina el estatuto epistemológico de la bioética como disciplina académica. El autor sostiene que el estatuto epistemológico de un discurso lo determina la pregunta fundamental que se plantea y la respuesta que se busca, focos integradores del discurso. En el caso de la bioética, la pregunta fundamental es de índole moral. La bioética es pues una disciplina ética que tiene su hogar epistemológico en la filosofía. El autor también defiende el concepto de “éticas aplicadas”. Sugiere finalmente que el método de la bioética, sobre todo la que se hace desde nuestras latitudes, debería adoptar el círculo hermenéutico como metodología para su filosofar. PMID:20463860

  2. La Persona como Eje Fundamental del Paradigma Humanista

    Directory of Open Access Journals (Sweden)

    Monserrat Georgina Aizpuru Cruces

    2012-02-01

    Full Text Available Para el desarrollo de una educación humanista es necesario centrar el paradigma pedagógico en la persona y que ésta sea concebida de una manera integral, como una totalidad. En este paradigma se desenvuelven aprendizajes significativos vivenciales, partiendo de la experiencia misma del educando, utilizando métodos activos de aprendizaje y conceptualizando a la educación como una experiencia creadora. Así mismo, es indispensable que existan programas flexibles, multi y transdisciplinarios. Por otra parte, la autoevaluación es un proceso reflexivo permanente que puede trasladarse a todos los aspectos de su vida y no sólo quedarse en el aula. Por último, los valores más importantes que promueve el modelo son el respeto, la tolerancia, la libertad, todos ellos básicos para la convivencia humana.

  3. O Corpo Queer Como "Imagem-Mentira" na Telenovela Brasileira

    Directory of Open Access Journals (Sweden)

    Juliana Ribeiro Pinto Bravo

    2016-12-01

    Full Text Available Este artigo tem o objetivo de propor a materialidade do corpo queer como um produto estilizado pela telenovela brasileira, justamente, por este corpo pertencer a um processo de montagem que prioriza na imagem a evidência de certa ausência. Dessa forma, a representação do corpo queer é um elemento visual de uma montagem ideológica coerente. Portanto, é preciso analisar as estruturas textuais televisivas, os aportes teóricos queer e as próprias definições de montagem e ausência. A partir do conceito de “Imagem-Mentira” de Didi-Huberman, nomes como John Fiske, John Hartley, Judith Butler, Michel Foucault e Jacques Rancière servirão de base teórica para a discussão.

  4. El icófono musical como portador publicitario

    Directory of Open Access Journals (Sweden)

    Manuel Gértrudix Barrio

    2012-04-01

    Full Text Available A partir del análisis semiótico dela música, entendida esta comosistema semiótico no-lingüísticoque se fundamenta en el ámbitoexpresivo, se justifica un nuevoelemento de significación que,bajo la denominación de Icofonomusical, actúa como un supersignoacústico aislado, capacitado paraactivar en el auditor, como fragmento textual, un área de significación autónoma.Desde la percepción provisoria desu naturaleza, se indaga entresus capacidades y características publicitarias, y se detectauna actualización concreta cuyovalor y funcio-nalidad es extraordinaria en el ámbito publicitarioaudiovisual: el fonotipo se revelacomo un interesante instrumentopara la identificación expresa dela marca y del producto.

  5. 77 FR 44139 - Drawbridge Operation Regulation; Sacramento River, Sacramento, CA

    Science.gov (United States)

    2012-07-27

    ... Operation Regulation; Sacramento River, Sacramento, CA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary... Sacramento, CA. The deviation is necessary to allow the community to participate in the Fleet Feet Event, Run... Tower Drawbridge, mile 59.0, Sacramento River, at Sacramento, CA. The Tower Drawbridge navigation span...

  6. 76 FR 11960 - Drawbridge Operation Regulation; Sacramento River, Sacramento, CA

    Science.gov (United States)

    2011-03-04

    ... Operation Regulation; Sacramento River, Sacramento, CA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary..., mile 59.0, at Sacramento, CA. The deviation is necessary to allow the community to participate in the... Tower Drawbridge, mile 59.0, Sacramento River, at Sacramento, CA. The Tower Drawbridge navigation span...

  7. 77 FR 22216 - Drawbridge Operation Regulation; Sacramento River, Sacramento, CA

    Science.gov (United States)

    2012-04-13

    ... Operation Regulation; Sacramento River, Sacramento, CA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary... schedule that governs the Tower Drawbridge across the Sacramento River, mile 59.0, at Sacramento, CA. The... River, at Sacramento, CA. The Tower Drawbridge navigation span provides a vertical clearance of 30 feet...

  8. 78 FR 42452 - Drawbridge Operation Regulation; Sacramento River, Sacramento, CA

    Science.gov (United States)

    2013-07-16

    ... Operation Regulation; Sacramento River, Sacramento, CA AGENCY: Coast Guard, DHS. ACTION: Notice of deviation... Sacramento, CA. The deviation is necessary to allow the bridge owner to make bridge repairs. This deviation... Sacramento, CA. The drawbridge navigation span provides 109 feet vertical clearance above Mean High Water in...

  9. 77 FR 52599 - Drawbridge Operation Regulation; Sacramento River, Sacramento, CA

    Science.gov (United States)

    2012-08-30

    ... Operation Regulation; Sacramento River, Sacramento, CA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary... regulation that governs the Tower Drawbridge across Sacramento River, mile 59.0, at Sacramento, CA. The... change to the operation of the Tower Drawbridge, mile 59.0, over Sacramento River, at Sacramento, CA. The...

  10. 76 FR 26181 - Drawbridge Operation Regulation; Sacramento River, Sacramento, CA

    Science.gov (United States)

    2011-05-06

    ... Operation Regulation; Sacramento River, Sacramento, CA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary... 59.0, at Sacramento, CA. The deviation is necessary to allow the community to participate in the Hope... Drawbridge, mile 59.0, over Sacramento River, at Sacramento, CA. The drawbridge navigation span provides a...

  11. 76 FR 11679 - Drawbridge Operation Regulation; Sacramento River, Sacramento, CA

    Science.gov (United States)

    2011-03-03

    ... Operation Regulation; Sacramento River, Sacramento, CA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary..., mile 59.0, at Sacramento, CA. The deviation is necessary to allow the community to participate in the... the Tower Drawbridge, mile 59.0, Sacramento River, at Sacramento, CA. The Tower Drawbridge navigation...

  12. 76 FR 23188 - Drawbridge Operation Regulation; Sacramento River, Sacramento, CA

    Science.gov (United States)

    2011-04-26

    ... Operation Regulation; Sacramento River, Sacramento, CA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary..., mile 59.0, at Sacramento, CA. The deviation is necessary to allow the community to participate in the... Tower Drawbridge, mile 59.0, Sacramento River, at Sacramento, CA. The Tower Drawbridge navigation span...

  13. 76 FR 79067 - Drawbridge Operation Regulation; Sacramento River, Sacramento, CA

    Science.gov (United States)

    2011-12-21

    ... Operation Regulation; Sacramento River, Sacramento, CA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary..., mile 59.0, at Sacramento, CA. The deviation is necessary to allow community celebration of New Year's... Tower Drawbridge, mile 59.0, Sacramento River, at Sacramento, CA. The Tower Drawbridge navigation span...

  14. 76 FR 20843 - Drawbridge Operation Regulation; Sacramento River, Sacramento, CA

    Science.gov (United States)

    2011-04-14

    ... Operation Regulation; Sacramento River, Sacramento, CA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary..., mile 59.0, at Sacramento, CA. The deviation is necessary to allow the community to participate in the... the Tower Drawbridge, mile 59.0, Sacramento River, at Sacramento, CA. The Tower Drawbridge navigation...

  15. 77 FR 10372 - Drawbridge Operation Regulation; Sacramento River, Sacramento, CA

    Science.gov (United States)

    2012-02-22

    ... Operation Regulation; Sacramento River, Sacramento, CA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary..., mile 59.0, at Sacramento, CA. The deviation is necessary to allow the community to participate in the... Tower Drawbridge, mile 59.0, Sacramento River, at Sacramento, CA. The Tower Drawbridge navigation span...

  16. 77 FR 10371 - Drawbridge Operation Regulation; Sacramento River, Sacramento, CA

    Science.gov (United States)

    2012-02-22

    ... Operation Regulation; Sacramento River, Sacramento, CA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary..., mile 59.0, at Sacramento, CA. The deviation is necessary to allow the bridge owner to conduct... change to the operation of the Tower Drawbridge, mile 59.0, Sacramento River, at Sacramento, CA. The...

  17. 75 FR 16006 - Drawbridge Operation Regulation; Sacramento River, Sacramento, CA

    Science.gov (United States)

    2010-03-31

    ... Operation Regulation; Sacramento River, Sacramento, CA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary..., mile 59.4, at Sacramento, CA. The deviation is necessary to allow the bridge owner to make bridge... Sacramento River, at Sacramento, CA. The I Street Drawbridge navigation span provides 109 feet vertical...

  18. 78 FR 23489 - Drawbridge Operation Regulation; Sacramento River, Sacramento, CA

    Science.gov (United States)

    2013-04-19

    ... Operation Regulation; Sacramento River, Sacramento, CA AGENCY: Coast Guard, DHS. ACTION: Notice of deviation... operating regulation that governs the Tower Drawbridge across Sacramento River, mile 59.0, at Sacramento, CA... Tower Drawbridge, mile 59.0, over Sacramento River, at Sacramento, CA. The Tower Drawbridge navigation...

  19. Ca and Mg binding induce conformational stability of Calfumirin-1 ...

    Indian Academy of Sciences (India)

    The thermal unfolding curves of wtCAF-1 monitored at neutral pH by CD spectroscopy are reversible and show ... These domains have either structurally dependent or independent Ca2+- ... that behave as a Ca2+ sensor protein, CaBP1 and.

  20. Electronic structure of Ca, Sr, and Ba under pressure.

    Science.gov (United States)

    Animalu, A. O. E.; Heine, V.; Vasvari, B.

    1967-01-01

    Electronic band structure calculations phase of Ca, Sr and Ba over wide range of atomic volumes under pressure electronic band structure calculations for fcc phase of Ca, Sr and Ba over wide range of atomic volumes under pressure electronic band structure calculations for fcc phase of Ca, Sr and Ba over wide range of atomic volumes under pressure

  1. TRPV5, the gateway to Ca2+ homeostasis.

    NARCIS (Netherlands)

    Mensenkamp, A.R.; Hoenderop, J.G.J.; Bindels, R.J.M.

    2007-01-01

    Ca2+ homeostasis in the body is tightly controlled, and is a balance between absorption in the intestine, excretion via the urine, and exchange from bone. Recently, the epithelial Ca2+ channel (TRPV5) has been identified as the gene responsible for the Ca2+ influx in epithelial cells of the renal

  2. JOGOS PAISAGÍSTICOS: MAPAS E ATLAS COMO CONCEITOS OPERATIVOS

    Directory of Open Access Journals (Sweden)

    Frederico Canuto

    2014-04-01

    Full Text Available O presente artigo coloca em discussão a produção de paisagens como prática que pode envolver diferentes agentes e percepções, não sendo estreitamente vinculado a um único olhar dito objetivo. A partir de tal discussão, mapas e atlas, instrumentos cartográficos por demais usuais, são aqui transformados em conceitos para se pensar a paisagem e sua produção na contemporaneidade levando em conta diferentes recortes epistemológicos, pontos de vista, agentes e sujeitos. Usando o conceito de espasmos advindo da critica do filósofo francês Gilles Deleuze a respeito das pinturas Francis Bacon, tais operadores serão discutidos como espaços autônomos de produção de paisagens a despeito de qualquer imagem exterior existente a priori. Serão usadas duas obras que, por sua vez, apontarão para a definição destes mesmos operadores: o trabalho artístico participativo Alter Bahnhof Vídeo Walk dos artistas Janet Cardiff e George Miller apresentado na DOCUMENTA XIII de Kassel em 2012 e o site interativo We feel Fine. An Exploration of Human Emotion, in Six Movements feito pelos designers Jonathan Harris e Sep Kamvar. E na conclusão, pretende-se discutir o mapa e atlas não como instrumentos de leitura de um real, mas eles mesmos como um real narrativo.

  3. Parte de la Naturaleza: sobre el cuerpo como potencia compositiva

    Directory of Open Access Journals (Sweden)

    Juliana Merçon

    2012-11-01

    Full Text Available http://dx.doi.org/10.5007/2175-795X.2012v30n2p473 En medio de la constelación de mitos que han contribuido a la actual crisis socioecológica,se encuentra la creencia de que somos individuos sustanciales, atomizadoso separados del entorno al cual intentamos ‘dominar’. La ignorancia con respecto anuestra interdependencia ontológica está en la base de muchas de nuestras posturas(auto destructivas y ha sido reforzada por diversos sistemas teóricos a lo largo de lahistoria occidental. Al margen de dualismos platónicos, de transcendencias judaicocristianasy del cogito cartesiano, la filosofía de Benedictus de Spinoza (1632-1677nos invita a repensar los fundamentos de la realidad compleja en la cual estamosinmersos. Mi propósito en este artículo es tejer relaciones productivas entre algunasdimensiones de su filosofía, el pensamiento ambiental y la educación. El punto departida será la concepción spinozista de cuerpo. Este será definido como potencia quese expresa a la vez como productividad (fuerza causal y sensibilidad (fuerza receptiva.El carácter esencialmente relacional y afectivo del cuerpo humano nos permitirápensarlo también como potencia compositiva. Desconstruyendo la dicotomíaentre Naturaleza y Cultura, propondré que reflexionemos sobre las composicioneshumano-tecnológicas con respecto a sus efectos sobre nuestra potencia de pensar yactuar. En conclusión, presentaré algunos comentarios sobre el rol de la educacióncomo espacio relacional, en el cual se pueden integrar de forma potenciadora lasdimensiones epistémica, ética, política y ambiental de nuestra existencia como partesinterdependientes de la Naturaleza.

  4. Utilización de pastas como alimentos funcionales

    OpenAIRE

    Martínez, Cristina S.

    2010-01-01

    Objetivo general Evaluar la aptitud de las pastas para actuar como alimentos funcionales, estudiando el efecto del agregado de diferentes ingredientes sobre su calidad tecnológica y nutricional. Objetivos específicos Objetivo I: estudiar los parámetros que definen la calidad de las pastas. Objetivo II: evaluar el efecto del almidón, del gluten y del agua sobre la calidad de las pastas frescas elaboradas con harina de trigo pan. Objetivo III:...

  5. El empowerment como predictor del compromiso organizacional en las Pymes

    OpenAIRE

    Ríos Manriquez Martha; Téllez Ramírez María del Rayo; Ferrer Guerra Julian

    2010-01-01

    La relación entre las variables de empowerment y compromiso organizacional ha sido un campo poco explorado desde la perspectiva organizacional. Esta investigación establece el nivel de influencia del empowerment queexperimentanloscolaboradores con respecto al compromiso hacia la organización para la cual laboran. Se utiliza como referencia un modelo generado con base en la descripción del empowerment en cuatro dimensiones: significado, competencia, autodeterminación e impacto; y del compromis...

  6. Chemical purification of CaCO{sub 3} and CaWO{sub 4} powders used for CaWO{sub 4} crystal production for the CRESST experiment

    Energy Technology Data Exchange (ETDEWEB)

    Trinh Thi, H.H.; Defay, X.; Erb, A.; Hampf, R.; Lanfranchi, J.C.; Langenkaemper, A.; Morgalyuk, V.; Muenster, A.; Mondragon, E.; Oppenheimer, C.; Potzel, W.; Schoenert, S.; Steiger, H.; Ulrich, A.; Wawoczny, S.; Willers, M.; Zoeller, A. [Physik-Department and Excellence Cluster Universe, Technische Universitaet Muenchen, Garching (Germany)

    2016-07-01

    CRESST (Cryogenic Rare Event Search with Superconducting Thermometers) uses CaWO{sub 4} single crystals as targets for the direct search for dark matter particles. Since several years these CaWO{sub 4} crystals are grown at the Technische Universitaet Muenchen. Thereby, commercially available CaCO{sub 3} and WO{sub 3} powders are used for the synthesis of CaWO{sub 4} powder. For the experiment low intrinsic contaminations of the crystals play a crucial role. In order to improve the radiopurity of the crystals it is necessary to reduce potential sources for radioactive backgrounds such as U and Th. In this poster we will present our studies of the chemical purification of the CaCO{sub 3} and CaWO{sub 4} powders.

  7. La tortilla como identidad culinaria y producto de consumo global

    Directory of Open Access Journals (Sweden)

    Margarita Calleja Pinedo

    2016-01-01

    Full Text Available La tortilla forma parte de la identidad culinaria de los mexicanos que viven en México o en el extranjero; es un componente básico de los antojitos, acompaña a los plati- llos festivos y es un suministro consuetudinario en la co- mida. Desde la época colonial, españoles, indios y mexica- nos produjeron en el norte del país una cultura culinaria, hoy conocida como tex-mex, que ha sido recreada por las olas constantes de migrantes, y aunque en México fue re- chazada, en Estados Unidos y en el imaginario global es reconocida como mexicana, de la que la tortilla de maíz o de trigo es un elemento identificador. A medida que las innovaciones en la comida rápida aumentan, la tortilla se ha convertido en un objeto comestible para el consumo global, desarraigado del patrimonio culinario de origen; como su cede en Shanghai, China, el caso analizado aquí.

  8. La virtualización como necesidad de cambio

    Directory of Open Access Journals (Sweden)

    Eleonora Parra de Párraga

    2002-09-01

    Full Text Available La idea básica en este artículo es efectuar un análisis sobre la realidad que viven muchas empresas, las cuales tienen un enfrentamiento temeroso y cauteloso con los cambios, aún cuando sean vistos como una necesidad de supervivencia en el mercado. La aparición de la figura del teletrabajo, la oficina virtual, el uso de las tecnologías de la información son aspectos a tratarse, además de estudiar brevemente los marcadores de productividad, y la pérdida de control que las empresas virtuales pueden acarrear a futuro. Por ello, la mayoría de estos conglomerados, ha visto como una solución a sus problemas de aceptación y permanencia en el mundo comercial la utilización de esta forma de acercamiento con el público usuario o consumidor de sus servicios o productos. Lo vital, es presentarle otras alternativas, tan atractivas entre ellas como para elegir la más conveniente, según las necesidades del momento, del propio individuo y de su entorno.

  9. El desarrollo de la marcha infantil como proceso de aprendizaje

    Directory of Open Access Journals (Sweden)

    Patricia Martín Casas

    2014-06-01

    Full Text Available El desarrollo de la marcha infantil es un proceso especialmente complejo en que el intervienen factores motores, perceptivos y cognitivos. Desde el nacimiento, el niño integra la información recibida y realiza un progresivo control cortical sobre los patrones neuromotores innatos para desarrollar diferentes formas de locomoción hasta la marcha independiente. Estas ideas no son novedosas pero se están revisando en la actualidad y han motivado numerosos cambios en el estudio del desarrollo infantil. La consideración de la adquisición de la marcha como un aprendizaje en situaciones de constante cambio permite comprender la marcha como acción, cuya realización implica la adquisición de nuevas capacidades de interacción y conocimientos. En este trabajo se exponen los principales conocimientos acerca de este proceso de aprendizaje y se propone destacar las alteraciones de la marcha como indicadores de dificultades en el desarrollo, que requieren una valoración y un abordaje terapéutico interdisciplinares.

  10. AFINAL, COMO SE FORMAM AS ESTRATÉGIAS?

    Directory of Open Access Journals (Sweden)

    Maurício Fernandes Pereira

    2007-12-01

    Full Text Available Tem havido recentemente um grande interesse por parte dos autores em entender como se desenvolve a prática da estratégia organizacional. Partindo desta tendência, o presente trabalho descreve como ocorre o processo de formação estratégica em uma organização pertencente ao terceiro setor – o SESC/SC (Serviço Social do Comércio em Santa Catarina. A criação da estratégia na organização em estudo é analisada tomando-se como base os referenciais propostos por Whittington (2002, analisando duas dimensões principais: os resultados pretendidos com as estratégias e os processos pelos quais ela acontece. Com base nos dados coletados observou-se que, na prática da organização pesquisada, as razões que levam ao estabelecimento da estratégia não estão unicamente voltadas aos aspectos econômicos. Quanto à formação das estratégias, no caso estudado, predominou a formação da estratégia da visão clássica de Whittington (2002, por meio da utilização do planejamento estratégico.

  11. Sistema cenagoso de ayapel como posible sitio Ramsar en Colombia

    Directory of Open Access Journals (Sweden)

    Tatiana Puerta Quintana

    2016-01-01

    Full Text Available Colombia, al ser parte de la Convención internacional de humedales Ramsar, tiene como tarea la gestión de los humedales del país, incluyendo aquellos ecosistemas estratégicos que cumplan con uno o más criterios según los lineamientos dispuestos por la Convención. Este artículo describe el procedimiento a seguir para postular el sistema cenagoso de Ayapel como posible sitio Ramsar en Colombia. Se consolidaron los trabajos de investigación para demostrar que el sistema cenagoso de Ayapel cumple con varios criterios establecidos por la Convención. Como resultado relevante se obtuvo el insumo base para el proceso de postulación en la Convención (Ficha Ramsar. Este es el primer paso de un proyecto marco encaminado a la gestión y conservación de un ecosistema que sufre perturbaciones y transformaciones por actividades antrópicas, del cual depende en gran medida una población humana, de fauna y flora vulnerable, asociada a la dinámica de funcionamiento y servicios ecosistémicos del humedal. Además, se muestra el proceso de socialización de la Ficha Ramsar con la comunidad directamente involucrada, la cual acoge el proyecto de manera positiva.

  12. COMO LLEGA EL MARKETING A LOS EMPRENDEDORES LATINO AMERICANOS

    Directory of Open Access Journals (Sweden)

    Jimmy Federico Telléz Figueroa

    2014-06-01

    Full Text Available Los tiempos de las ciencias puras, al parecer están en una encrucijada muy compleja. Partiendo por lo que en realidad entendemos hoy como ciencia pura. Desde los años cincuenta, cuando el Marketing nace al mundo científico, académico y practico como tal, esta ciencia en particular ha visto en su existencia la forzosa necesidad de transformarse no solo de forma sino de fondo, es decir, cambios en su forma de presentación hasta cambios conceptuales, que ya en los años setenta se tuvieron que redefinir, incluso poniendo en entredicho, si realmente el Marketing era una ciencia, o finalmente un arte, con sus planteamientos expuestos en una inevitable lectura de su zaga de Marketing Practico y Aplicado, que como todos sabemos se inicio en 1972 con la obra “El Posicionamiento” y que un par de años después revolucionaria la teoría científica de esta entre comillas ciencia, cuando aparece su postulado practico y aplicado con la obra “La Guerra de la Mercadotecnia”, perpetuando en los lectores de la época, la portada de su libro, con la imagen del tanque saliendo del maletín ejecutivo, sobre una mesa de reuniones.

  13. A estética como factor promotor da aprendizagem

    Directory of Open Access Journals (Sweden)

    Fátima Maria BEZERRA BARBOSA

    2012-02-01

    Full Text Available La reflexión filosófica sobre el arte, lo hermoso, lo bueno, lo verdadero y su capacidad de promover el desarrollo humano es un tema que remonta a Platón en la cultura occidental. Considerando que la educación debe ser entendida como un fenómeno integral, que abarca no sólo las dimensiones intelectuales sino también las dimensiones sensibles, la intuición y el raciocinio, las capacidades imaginativas y creativas, el «saber ser» y el «saber estar» parejas del «conocer» y del «saber hacer», pensamos que es incuestionable la importancia de la estética en el fenómeno educativo. El objetivo de este trabajo es demostrar la importancia de la educación estética como motor fundamental de desarrollo humano y, en este sentido, como catalizador de la motivación y del aprendizaje, para que, a través de la imaginación y de la creatividad, sea posible la innovación en la construcción de vías alternativas para un mundo más humano y placentero.

  14. Diplopia como primeiro sintoma de esclerose múltipla

    Directory of Open Access Journals (Sweden)

    Maria Auxiliadora Monteiro Frazão

    2015-04-01

    Full Text Available Objetivo: Determinar a frequência e as características clínicas das alterações da motilidade ocular extrínseca em indivíduos portadores de esclerose múltipla, residentes no estado de São Paulo, em série de casos consecutivos de 1996 a 2011. Métodos: Foram selecionados oitenta e três indivíduos com esclerose múltipla, com idade entre 17 e 59 anos. Todos foram submetidos à anamnese e exame ocular completo. Resultados: Alterações da motilidade ocular extrínseca foram encontradas em 17 ( 20,48% dos 83 indivíduos. A diplopia ocorreu como primeiro sintoma da doença em 11 (13,25% indivíduos. Conclusão: A frequência de diplopia como primeiro sintoma de esclerose múltipla é relevante. Por esse fato, é fundamental ressaltar a importância da difusão do conhecimento desse achado para a realização de diagnóstico precoce de esclerose múltipla, tanto para o oftalmologista geral, como para o médico generalista, melhorando assim o prognóstico dos pacientes que dela padecem.

  15. HABILIDADES E ATRIBUTOS DO ENFERMEIRO COMO COORDENADOR DE GRUPOS

    Directory of Open Access Journals (Sweden)

    CARLA NATALINA DA SILVA FERNANDES

    2008-01-01

    Full Text Available Coordinar grupos es una actividad cada vez más frecuente para los enfermeros, que deben tener conocimiento especí- fico para alcanzar los objetivos propuestos y para aprovechar el potencial de las personas implicadas. Se trata de una investigación teórica que tiene como objetivo discutir y reflexionar sobre algunos atributos deseables en los enfermeros como coordinadores de grupos, basado en el estudio de Godoy, literatura clásica de la Dinámica de Grupo y estudios contemporáneos publicados en periódicos especializados nacionales e internacionales. El artículo está organizado en dos momentos; en el primero se presentan algunas bases teóricas de la coordinación de grupos y, en el segundo, las cualidades deseadas en un coordinador. Estos elementos son discutidos como herramientas aprovechadas por los enfermeros en la conducción de los grupos con el propósito de realizar actividades de asistencia, formación de recursos humanos o para el desarrollo de investigaciones. La praxis de la coordinación implica un sistema de capacidades técnicas y científicas; amplio conocimiento de las relaciones interpersonales, auto conocimiento, sensibilidad y creatividad para que, en efecto, el desempeño del enfermero promueva una mayor atención de las demandas en el área de la salud.

  16. La comunicación corno quehacer y como problema

    Directory of Open Access Journals (Sweden)

    Javier Luis Mier

    2015-01-01

    Full Text Available Este número aborda la comunicación desde las tres interpretaciones más importantes: la tradicionalista, la militar y mercantilista y el arte popular tan inestable, cuestionado y cambiante. Canclini cuestiona la compartamentalización de cultura: popular y de medios y esboza los problemas que plantea la tradicional miopía de no reconocer la universalización y ubicuidad de la cultura de masas. Se agregan otros temas como: ¿Re-intelección de los medios? apuntes sobre un libro de los Mattelart, ¿"Ética" o "Deontología"?, El lenguaje del vestido y de la fiesta,Talleres de cultura Popular en Santiago de Chile, El dilema del arte popular en Bolivia,¿Sobrevivirán las artesanías aborígenes argentinas?, Los tejedores de El Tintorero, Tecnologías de computación y Tercer Mundo, La cobertura del terremoto en México, La comunicación como quehacer y como problema, la comunicación planificada sirve al desarrollo

  17. Ultrastructural and immunohistochemical localization of plasma membrane Ca2+-ATPase 4 in Ca2+-transporting epithelia

    DEFF Research Database (Denmark)

    Alexander, R Todd; Beggs, Megan R; Zamani, Reza

    2015-01-01

    role in transcellular Ca(2+) flux and investigated the localization and regulation of Pmca4 in Ca(2+)-transporting epithelia. Using antibodies directed specifically against Pmca4, we found it expressed only in the smooth muscle layer of mouse and human intestine, while pan-specific Pmca antibodies...... the cortical thick ascending limbs, macula densa, and early distal tubules as well as smooth muscle layers surrounding renal vessels. In human kidney, a similar pattern of distribution was observed, with highest PMCA4 expression in NCC positive tubules. Electron microscopy demonstrated Pmca4 localization...... in distal nephron cells at both the basolateral membrane and intracellular perinuclear compartments, but not submembranous vesicles, suggesting rapid trafficking to the plasma membrane is unlikely to occur in vivo. Pmca4 expression was not altered by perturbations in Ca(2+) balance, pointing...

  18. Tumor markers CA19-9, CA242 and CEA in the diagnosis of pancreatic cancer: a meta-analysis.

    Science.gov (United States)

    Zhang, Yimin; Yang, Jun; Li, Hongjuan; Wu, Yihua; Zhang, Honghe; Chen, Wenhu

    2015-01-01

    Pancreatic cancer has the worst prognosis and early detection is crucial for improving patient prognosis. Therefore, we performed a meta-analysis to evaluate and compare the sensitivity and specificity of single test of CA19-9, CA242, and CEA, as well as combination test in pancreatic cancer detection. We searched PubMed, Embase, Medline, and Wanfang databases for studies that evaluated the diagnostic validity of CA19-9, CA242, and CEA between January 1990 and September 2014. Data were analyzed by Meta-Disc and STATA software. A total of 21 studies including 3497 participants, which fulfilled the inclusion criteria were considered for analysis. The pooled sensitivities for CA19-9, CA242, and CEA were 75.4 (95% CI: 73.4-77.4), 67.8 (95% CI: 65.5-70), and 39.5 (95% CI: 37.3-41.7), respectively. The pooled specificities of CA19-9, CA242, and CEA were 77.6 (95% CI: 75.4-79.7), 83 (95% CI: 81-85), and 81.3 (95% CI: 79.3-83.2), respectively. Parallel combination of CA19-9+CA242 has a higher sensitivity (89, 95% CI: 80-95) without impairing the specificity (75, 95% CI: 67-82). Our meta-analysis showed that CA242 and CA19-9 have better performance in the diagnosis of pancreatic cancer than CEA. Furthermore, parallel combination test of CA19-9+CA242 could be of better diagnostic value than individual CA242 or CA19-9 test.

  19. Mechanics of Old Faithful Geyser, Calistoga, CA

    Science.gov (United States)

    Rudolph, M.L.; Manga, M.; Hurwitz, Shaul; Johnston, Malcolm J.; Karlstrom, L.; Wang, Chun-Yong

    2012-01-01

    In order to probe the subsurface dynamics associated with geyser eruptions, we measured ground deformation at Old Faithful Geyser of Calistoga, CA. We present a physical model in which recharge during the period preceding an eruption is driven by pressure differences relative to the aquifer supplying the geyser. The model predicts that pressure and ground deformation are characterized by an exponential function of time, consistent with our observations. The geyser's conduit is connected to a reservoir at a depth of at least 42 m, and pressure changes in the reservoir can produce the observed ground deformations through either a poroelastic or elastic mechanical model.

  20. Quasielastic electron scattering from 40Ca

    International Nuclear Information System (INIS)

    Williamson, C.F.; Yates, T.C.; Schmitt, W.M.; Osborn, M.; Deady, M.; Zimmerman, P.D.; Blatchley, C.C.; Seth, K.K.; Sarmiento, M.; Parker, B.; Jin, Y.; Wright, L.E.; Onley, D.S.

    1997-01-01

    Differential cross sections for quasielastic electron scattering on 40 Ca have been measured at laboratory scattering angles of 45.5 degree, 90 degree, and 140 degree with bombarding energies ranging from 130 to 840 MeV. Transverse and longitudinal response functions have been extracted for momentum transfers from 300 to 500 MeV/c. Contrary to some previously reported results, the total observed longitudinal strength agrees with the relativistic Fermi gas prediction to within ±18%. copyright 1997 The American Physical Society

  1. β-decay of 37Ca

    International Nuclear Information System (INIS)

    Trinder, W.; Adelberger, E.G.; Keller, H.; Krumbholz, K.; Rykaczewski, K.

    1994-11-01

    The β-decay of 37 Ca has been studied. The half-life was remeasured with improved precision to be 181(1) ms, and β-delayed γ-rays were observed for the first time. The surprisingly high Γ γ /Γ p values for proton-unbound states in 37 K drastically reduce former discrepancies between the Gamow-Teller strength values B(GT) measured in the 37 Ga β-decay and those deduced from the 37 Cl(p, n) 37 Ar mirror reaction. (orig.)

  2. QUANTICOL - CaSL at work

    OpenAIRE

    Galpin, Vashti; Georgoulas, Anastasis; Gilmore, Stephen; Hillston, Jane; Latella, Diego; Loreti, Michele; Massink, Mieke; Zon, Natalia

    2017-01-01

    This deliverable reports on the work completed in the final reporting period on the modelling language at the centre of the QUANTICOL framework, C ARMA . A major focus of the period has been on making modelling with C ARMA accessible to a wide audience of potential users interested in CAS, not just those already familiar with formal modelling with process algebras. To this end we have further developed the C ARMA Specification Language ( CaSL ) and the software tools that support it; we have ...

  3. Cold fusion reactions with 48Ca

    International Nuclear Information System (INIS)

    Gaeggeler, H.W.; Jost, D.T.; Tuerler, A.

    1989-04-01

    Cold fusion reactions with 48 Ca on the targets 208 Pb, 209 Bi, 197 Au, 184 W, 180 Hf are reported. The experiments were performed at the velocity filter SHIP of GSI. The maximum cross sections show a steep descent by about four orders of magnitude when going from 224 Th to 228 U as compound nuclei. Between uranium and einsteinium the cross sections stay rather low and increase by about two orders of magnitude for nobelium. For lawrencium the cross section decrease again. 7 figs., 1 tab., 38 refs

  4. Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise

    DEFF Research Database (Denmark)

    Rose, Adam John; Kiens, Bente; Richter, Erik

    2006-01-01

    Ca2+ signalling is proposed to play an important role in skeletal muscle function during exercise. Here, we examined the expression of multifunctional Ca2+-calmodulin-dependent protein kinases (CaMK) in human skeletal muscle and show that CaMKII and CaMKK, but not CaMKI or CaMKIV, are expressed...

  5. The other side of cardiac Ca2+ signaling: transcriptional control

    Directory of Open Access Journals (Sweden)

    Alejandro eDomínguez-Rodríquez

    2012-11-01

    Full Text Available Ca2+ is probably the most versatile signal transduction element used by all cell types. In the heart, it is essential to activate cellular contraction in each heartbeat. Nevertheless Ca2+ is not only a key element in excitation-contraction coupling (EC coupling, but it is also a pivotal second messenger in cardiac signal transduction, being able to control processes such as excitability, metabolism, and transcriptional regulation. Regarding the latter, Ca2+ activates Ca2+-dependent transcription factors by a process called excitation-transcription coupling (ET coupling. ET coupling is an integrated process by which the common signaling pathways that regulate EC coupling activate transcription factors. Although ET coupling has been extensively studied in neurons and other cell types, less is known in cardiac muscle. Some hints have been found in studies on the development of cardiac hypertrophy, where two Ca2+-dependent enzymes are key actors: Ca2+/Calmodulin kinase II (CaMKII and phosphatase calcineurin, both of which are activated by the complex Ca2+/ /Calmodulin. The question now is how ET coupling occurs in cardiomyocytes, where intracellular Ca2+ is continuously oscillating. In this focused review, we will draw attention to location of Ca2+ signaling: intranuclear ([Ca2+]n or cytoplasmic ([Ca2+]c, and the specific ionic channels involved in the activation of cardiac ET coupling. Specifically, we will highlight the role of the 1,4,5 inositol triphosphate receptors (IP3Rs in the elevation of [Ca2+]n levels, which are important to locally activate CaMKII, and the role of transient receptor potential channels canonical (TRPCs in [Ca2+]c, needed to activate calcineurin.

  6. Comparison of phosgene, chlorine, and hydrogen chloride as reagents for converting molten CaO.CaCl2 to CaCl2

    International Nuclear Information System (INIS)

    Fife, K.W.

    1985-01-01

    One method at Los Alamos for preparing impure plutonium metal from the impure oxide is by batch reduction with calcium metal at 850 0 C in a CaCl 2 solvent. The solvent salt from this reduction is currently discarded as low-level radioactivity waste only because it is saturated with the CaO byproduct. We have demonstrated a pyrochemical technique for converting the CaO to CaCl 2 thereby incorporating solvent recycling into the batch reduction process. We will discuss the effectiveness of HCl, Cl 2 , and COCl 2 as chlorinating agents and recycling actual spent process solvent salts. 6 refs., 8 figs

  7. Intracellular alkalinization induces cytosolic Ca2+ increases by inhibiting sarco/endoplasmic reticulum Ca2+-ATPase (SERCA.

    Directory of Open Access Journals (Sweden)

    Sen Li

    Full Text Available Intracellular pH (pHi and Ca(2+ regulate essentially all aspects of cellular activities. Their inter-relationship has not been mechanistically explored. In this study, we used bases and acetic acid to manipulate the pHi. We found that transient pHi rise induced by both organic and inorganic bases, but not acidification induced by acid, produced elevation of cytosolic Ca(2+. The sources of the Ca(2+ increase are from the endoplasmic reticulum (ER Ca(2+ pools as well as from Ca(2+ influx. The store-mobilization component of the Ca(2+ increase induced by the pHi rise was not sensitive to antagonists for either IP(3-receptors or ryanodine receptors, but was due to inhibition of the sarco/endoplasmic reticulum Ca(2+-ATPase (SERCA, leading to depletion of the ER Ca(2+ store. We further showed that the physiological consequence of depletion of the ER Ca(2+ store by pHi rise is the activation of store-operated channels (SOCs of Orai1 and Stim1, leading to increased Ca(2+ influx. Taken together, our results indicate that intracellular alkalinization inhibits SERCA activity, similar to thapsigargin, thereby resulting in Ca(2+ leak from ER pools followed by Ca(2+ influx via SOCs.

  8. F-actin-based Ca signaling-a critical comparison with the current concept of Ca signaling.

    Science.gov (United States)

    Lange, Klaus; Gartzke, Joachim

    2006-11-01

    A short comparative survey on the current idea of Ca signaling and the alternative concept of F-actin-based Ca signaling is given. The two hypotheses differ in one central aspect, the mechanism of Ca storage. The current theory rests on the assumption of Ca-accumulating endoplasmic/sarcoplasmic reticulum-derived vesicles equipped with an ATP-dependent Ca pump and IP3- or ryanodine-sensitive channel-receptors for Ca-release. The alternative hypothesis proceeds from the idea of Ca storage at the high-affinity binding sites of actin filaments. Cellular sites of F-actin-based Ca storage are microvilli and the submembrane cytoskeleton. Several specific features of Ca signaling such as store-channel coupling, quantal Ca release, spiking and oscillations, biphasic and "phasic" uptake kinetics, and Ca-induced Ca release (CICR), which are not adequately described by the current concept, are inherent properties of the F-actin system and its dynamic state of treadmilling. Copyright 2006 Wiley-Liss, Inc.

  9. Elementary properties of CaV1.3 Ca(2+) channels expressed in mouse cochlear inner hair cells.

    Science.gov (United States)

    Zampini, Valeria; Johnson, Stuart L; Franz, Christoph; Lawrence, Neil D; Münkner, Stefan; Engel, Jutta; Knipper, Marlies; Magistretti, Jacopo; Masetto, Sergio; Marcotti, Walter

    2010-01-01

    Mammalian cochlear inner hair cells (IHCs) are specialized to process developmental signals during immature stages and sound stimuli in adult animals. These signals are conveyed onto auditory afferent nerve fibres. Neurotransmitter release at IHC ribbon synapses is controlled by L-type Ca(V)1.3 Ca(2+) channels, the biophysics of which are still unknown in native mammalian cells. We have investigated the localization and elementary properties of Ca(2+) channels in immature mouse IHCs under near-physiological recording conditions. Ca(V)1.3 Ca(2+) channels at the cell pre-synaptic site co-localize with about half of the total number of ribbons present in immature IHCs. These channels activated at about 70 mV, showed a relatively short first latency and weak inactivation, which would allow IHCs to generate and accurately encode spontaneous Ca(2+) action potential activity characteristic of these immature cells. The Ca(V)1.3 Ca(2+) channels showed a very low open probability (about 0.15 at 20 mV: near the peak of an action potential). Comparison of elementary and macroscopic Ca(2+) currents indicated that very few Ca(2+) channels are associated with each docked vesicle at IHC ribbon synapses. Finally, we found that the open probability of Ca(2+) channels, but not their opening time, was voltage dependent. This finding provides a possible correlation between presynaptic Ca(2+) channel properties and the characteristic frequency/amplitude of EPSCs in auditory afferent fibres.

  10. EL TURISMO COMO SISTEMA SIGNIFICATIVO. IDEAS PARA LA GESTIÓN DE LAS EMPRESAS TURÍSTICAS

    Directory of Open Access Journals (Sweden)

    José Alberto Martínez González

    2013-06-01

    Full Text Available El turismo constituye un sistema significativo. Es un sistema porque integra de manera global y local elementos y procesos diversos que se nutren de inputs para ofrecer outputs turísticos; es significativo porque constituye un sector con un elevado impacto económico y social que está interrelacionado con otros sectores. La relación es tal que el turismo está constituyendo, ahora en tiempo de crisis, un sector acicate para otros. En la actualidad el sistema turístico es reconocido por su complejidad, por su carácter multidisciplinar, por su naturaleza caótica no lineal, así como por su necesaria sostenibilidad y responsabilidad social, aspectos que las empresas turísticas debieran considerar. El presente trabajo sintetiza las claves de la significatividad del turismo y presenta los principales modelos sistémicos que sobre el turismo se han desarrollado.

  11. Simulación de un algoritmo para controlar el nivel en tolva ante alimentación discontinua de caña

    Directory of Open Access Journals (Sweden)

    Fabricio Garelli

    2009-07-01

    Full Text Available Resumen: Los actuales métodos de control del transporte y preparación de la materia prima provocan graves problemas de discontinuidad en la alimentación al tren de molinos de caña en la industria azucarera en Cuba. La introducción masiva de la tecnología de convertidores de frecuencia para el control de velocidad de motores asincrónicos permite proponer la utilización de la velocidad de las esteras como variable manipulada para el control del nivel de la tolva. Este trabajo presenta una variante de control por velocidad considerando la altura del colchón de caña en la estera elevadora como una perturbación multiplicativa a la entrada de la planta. Se propone un algoritmo de adaptación de set-point por modo deslizante para limitar los transitorios en el nivel de caña en tolva provocados por las fluctuaciones en la alimentación de caña. El método propuesto requiere realimentar únicamente variables accesibles y es robusto ante cambios en la densidad de caña y/o ruido de medición. Su implementación es extremadamente sencilla para lazos de control por velocidad tipo PID. Palabras Clave: molienda de caña de azúcar, estera transportadora, molinos de caña, control PID, control de velocidad, modo deslizante, set-point adaptivo

  12. Tragédias nas escolas americanas: como entendê-las? Como impedir que voltem a acontecer?

    Directory of Open Access Journals (Sweden)

    Eva Paulino Bueno

    2011-05-01

    Full Text Available

    Este artigo dá uma visão histórica do direito de portar armas nos Estados Unidos, e como a existência e facilidade de obtenção de armas têm causado inúmeras tragédias em escolas. Fala também das diferentes maneiras que as pessoas reagem às tragédias e como impedir que ocorram.

  13. Production of 34S-labeled gypsum (Ca34SO4.2H2O Produção de gesso (Ca34SO4.2H2O, marcado com 34S

    Directory of Open Access Journals (Sweden)

    Alexssandra Luiza Rodrigues Molina Rossete

    2006-08-01

    Full Text Available Agricultural gypsum (CaSO4.2H2O stands out as an effective source of calcium and sulfur, and to control aluminum saturation in the soil. Labeled as 34S it can elucidate important aspects of the sulfur cycle. Ca34SO4.2H2O was obtained by chemical reaction between Ca(OH2 and H2(34SO4, performed under slow agitation. The acid was produced by ion exchange chromatography using the Dowex 50WX8 cation exchange resin and a Na2(34SO4 eluting solution. After precipitation, the precipitate was separated and dried in a ventilated oven at 60ºC. From 2.2 L H2SO4 0.2 mol L-1 and 33.6 g Ca(OH2, 73.7 ± 0.6 g Ca34SO4.2H2O were produced on average in the tests, representing a mean yield of 94.6 ± 0.8%, with 98% purity. The 34SO2 gas was obtained from Ca34SO4.2H2O in the presence of NaPO3 in a high vacuum line and was used for the isotopic determination of S in an ATLAS-MAT model CH-4 mass spectrometer.O gesso agrícola (CaSO4.2H2O destaca-se como fonte eficiente de cálcio e enxofre e na redução da saturação de alumínio no solo. O 34S como traçador isotópico pode elucidar aspectos importantes no ciclo do enxofre. Para tanto o Ca34SO4.2H2O foi obtido por reação química entre o Ca(OH2 e solução de H2(34SO4, realizada sob agitação lenta. O ácido foi produzido por cromatografia de troca iônica, utilizando resina catiônica Dowex 50WX8 e solução eluente de Na2(34SO4. Após a precipitação foi separado o precipitado e realizada a secagem em estufa ventilada à temperatura de 60ºC. Nos testes, a partir de 2,2 L de H2SO4 0,2 mol L-1 e 33,6 g de Ca(OH2, foram produzidos em média 73,7 ± 0,6 g de Ca34SO4.2H2O representando um rendimento médio de 94,6 ± 0,8%, com pureza de 98%. A partir do Ca34SO4.2H2O na presença de NaPO3, em linha de alto vácuo, obteve-se o gás 34SO2 utilizado para a determinação isotópica do S no espectrômetro de massas ATLAS-MAT modelo CH-4.

  14. Robots como ferramenta pedagógica nos primeiros anos a aprendizagem como participação

    Directory of Open Access Journals (Sweden)

    SÓNIA MATILDE PINTO CORREIA MARTINS

    2015-01-01

    Full Text Available El presente artículo describe y analiza un proyecto realizado con dos grados del 1er ciclo de enseñanza básica en Portugal (2doy 3er grado que trabajaron en conjunto con robots, tomando el aprendizaje como un fenómeno intrín-secamente relacionado a la participación en comunidades de práctica (Lave, 1996; Lave; Wenger, 1991. Se pretende caracterizar a los participantes, a la metodología de trabajo implementada, describirlos artefactos utilizados (robots y escritura de una historia y analizar la relación de los participantes con los robots, así como los patrones de participación que se relevaron con este tipo de trabajo. Se busca enfatizar e las contribuciones derivadas de la participación en ambientes sociales digitales para el aprendizaje de los alumnos, como la participación y la negociación conjunta de significados, la importancia de que los robots y la historia hayan sido “construidos” por los alumnos y la existencia de un repertorio compartido y un emprendi-miento conjunto.

  15. Chronic Loss of CA2 Transmission Leads to Hippocampal Hyperexcitability.

    Science.gov (United States)

    Boehringer, Roman; Polygalov, Denis; Huang, Arthur J Y; Middleton, Steven J; Robert, Vincent; Wintzer, Marie E; Piskorowski, Rebecca A; Chevaleyre, Vivien; McHugh, Thomas J

    2017-05-03

    Hippocampal CA2 pyramidal cells project into both the neighboring CA1 and CA3 subfields, leaving them well positioned to influence network physiology and information processing for memory and space. While recent work has suggested unique roles for CA2, including encoding position during immobility and generating ripple oscillations, an interventional examination of the integrative functions of these connections has yet to be reported. Here we demonstrate that CA2 recruits feedforward inhibition in CA3 and that chronic genetically engineered shutdown of CA2-pyramidal-cell synaptic transmission consequently results in increased excitability of the recurrent CA3 network. In behaving mice, this led to spatially triggered episodes of network-wide hyperexcitability during exploration accompanied by the emergence of high-frequency discharges during rest. These findings reveal CA2 as a regulator of network processing in hippocampus and suggest that CA2-mediated inhibition in CA3 plays a key role in establishing the dynamic excitatory and inhibitory balance required for proper network function. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. Common barrel and forward CA tracking algorithm

    Energy Technology Data Exchange (ETDEWEB)

    Mykhailo, Pugach [Goethe-Universitaet, Frankfurt (Germany); Frankfurt Institute for Advanced Studies, Frankfurt (Germany); KINR, Kyiv (Ukraine); Gorbunov, Sergey; Kisel, Ivan [Goethe-Universitaet, Frankfurt (Germany); Frankfurt Institute for Advanced Studies, Frankfurt (Germany); Collaboration: PANDA-Collaboration

    2016-07-01

    There are complex detector setups which consist of barrel (cylindrical) and forward parts, and such systems require a special approach in the registered charged particles track finding procedure. Currently the tracking procedure might be performed in both parts of such detector independently from each other, but the final goal on this direction is a creation of a combined tracking, which will work in both parts of the detector simultaneously. The basic algorithm is based on Kalman Filter (KF) and Cellular Automata (CA). And the tracking procedure in such a complex system is rather extraordinary as far as it requires 2 different models to describe the state vector of segments of the reconstructed track in the mathematical apparatus of the KF-algorithm. To overcome this specifics a mathematical apparatus of transition matrices must be developed and implemented, so that one can transfer from one track model to another. Afterwards the work of the CA is performed, which reduces to segments sorting, their union into track-candidates and selection of the best candidates by the chi-square criteria after fitting of the track-candidate by the KF. In this report the algorithm, status and perspectives of such combined tracking are described.

  17. Predictors of pretreatment CA125 at ovarian cancer diagnosis

    DEFF Research Database (Denmark)

    Babic, Ana; Cramer, Daniel W; Kelemen, Linda E

    2017-01-01

    PURPOSE: Cancer antigen 125 (CA125) is a glycoprotein expressed by epithelial cells of several normal tissue types and overexpressed by several epithelial cancers. Serum CA125 levels are mostly used as an aid in the diagnosis of ovarian cancer patients, to monitor response to treatment and detect...... in CA125 between studies and linear regression to estimate the association between epidemiologic factors and tumor characteristics and pretreatment CA125 levels. RESULTS: In age-adjusted models, older age, history of pregnancy, history of tubal ligation, family history of breast cancer, and family...... cancer recurrence. Besides tumor characteristics, CA125 levels are also influenced by several epidemiologic factors, such as age, parity, and oral contraceptive use. Identifying factors that influence CA125 levels in ovarian cancer patients could aid in the interpretation of CA125 values for individuals...

  18. Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.

    Directory of Open Access Journals (Sweden)

    Peter Rellos

    2010-07-01

    Full Text Available Long-term potentiation (LTP, a long-lasting enhancement in communication between neurons, is considered to be the major cellular mechanism underlying learning and memory. LTP triggers high-frequency calcium pulses that result in the activation of Calcium/Calmodulin (CaM-dependent kinase II (CaMKII. CaMKII acts as a molecular switch because it remains active for a long time after the return to basal calcium levels, which is a unique property required for CaMKII function. Here we describe the crystal structure of the human CaMKIIdelta/Ca2+/CaM complex, structures of all four human CaMKII catalytic domains in their autoinhibited states, as well as structures of human CaMKII oligomerization domains in their tetradecameric and physiological dodecameric states. All four autoinhibited human CaMKIIs were monomeric in the determined crystal structures but associated weakly in solution. In the CaMKIIdelta/Ca2+/CaM complex, the inhibitory region adopted an extended conformation and interacted with an adjacent catalytic domain positioning T287 into the active site of the interacting protomer. Comparisons with autoinhibited CaMKII structures showed that binding of calmodulin leads to the rearrangement of residues in the active site to a conformation suitable for ATP binding and to the closure of the binding groove for the autoinhibitory helix by helix alphaD. The structural data, together with biophysical interaction studies, reveals the mechanism of CaMKII activation by calmodulin and explains many of the unique regulatory properties of these two essential signaling molecules.This article can also be viewed as an enhanced version in which the text of the article is integrated with interactive 3-D representations and animated transitions. Please note that a web plugin is required to access this enhanced functionality. Instructions for the installation and use of the Web plugin are available in Text S1.

  19. Synthesis of Pure Ca(OH)2 Nanoparticles and Superhydrophobic Suspensions: Consolidation and Waterproofing of Architectural Heritage Materials

    Science.gov (United States)

    Madrid Mendoza, Juan Antonio

    El objetivo de esta tesis es investigar sobre la sintesis, propiedades y aplicaciones de las nanoparticulas de Ca(OH)2 para consolidar materiales patrimoniales arquitectonicos. Las nanoparticulas de Ca(OH)2 se han utilizado recientemente en la conservacion del patrimonio, aunque algunos aspectos de la sintesis no son completamente comprendidos. En el presente estudio, hemos desarrollado metodos optimizados para obtener nanoparticulas de alta pureza mediante sintesis de fase homogenea y heterogenea utilizando diferentes materiales de partida. Se han realizado del orden de cien sintesis en diferentes condiciones para comprobar la validez y fiabilidad del metodo sintetico. Los resultados confirman que la temperatura de reaccion tiene una gran influencia en el tamano y la morfologia de las nanoparticulas de Ca(OH)2. Ademas, se ha investigado la estabilidad de las nanoparticulas a lo largo del tiempo en mezclas de 2-propanol / agua, en las que se encontro que la ausencia de agua era critica para evitar la aglomeracion de Ca(OH)2. Una vez dispersas en 2-propanol, las nanoparticulas se han utilizado para consolidar sustratos reales (piedra, adobe y estuco) confirmando su alto rendimiento en terminos de consolidacion superficial y - cuando se mezcla con ciertos surfactantes - en reduccion de la absorcion de agua. Asimismo, se ha investigado el uso de nanoparticulas modificadas basadas en M(OH)2, donde M=Ca2+, Mg2+, con el objetivo de mejorar tanto la cohesion superficial como la durabilidad de los materiales patrimoniales (p. ej. piedra Tabaire). Finalmente, el tratamiento de consolidacion basado en nanoparticulas puras de Ca(OH)2 se utilizo en emplazamientos con valor patrimonial, como edificios historicos y yacimientos arqueologicos (Teatro Romano de Cartagena) obteniendo resultados satisfactorios. The aim of this thesis is to investigate on the synthesis, properties and applications of Ca(OH)2 nanoparticles to consolidate architectural heritage materials. Ca(OH)2

  20. El anisakis y sus enfermedades como enfermedad profesional

    Directory of Open Access Journals (Sweden)

    José Manuel Vicente Pardo

    Full Text Available El anisakis es un parásito complejo de los animales marinos. El hombre no es el hospedador adecuado, ya que en él la larva L3 no puede completar su ciclo vital, siendo por tanto un hospedador accidental u ocasional, que se interpone en el ciclo vital del nemátodo, y al que el anisakis le puede causar tanto la parasitación como la alergia, cuando ingiere pescado o cefalópodos crudos o poco cocinados: tales como sushi, sashimi, ceviche gravlax noruego, lomi-lomi hawaiano, así como pescados en escabeche, vinagre, desecado, ahumados, semiconservas, o en salazón que contengan este parásito en su forma de larva en estadio tres L3. Las enfermedades por anisakis constituyen un problema de salud pública, generalizado y que ha aumentado su incidencia en los últimos años. En 2012, se notificaron 20.000 casos de anisakiasis en todo el mundo. España es el segundo país con mayor número de intoxicaciones por Anisakis después de Japón. Diversos estudios en España sobre la prevalencia de la sensibilización reflejan una elevada prevalencia entre pacientes que han sufrido episodios de reacciones alérgicas. El 50 por ciento de quienes manipulan directamente el pescado presentan sensibilidad a anisakis. Siendo por tanto cada vez más común la afectación por y en el desarrollo del trabajo, constituyendo entonces procesos considerados como enfermedad profesional cuando se dan las circunstancias determinantes causales de trabajo, riesgo y exposición que para ello deben concurrir. La afección puede presentarse tanto por contacto laboral como por contacto en el consumo ordinario de pescado infestado, lo que hará difícil el estimar como causa exclusiva o consecuente la aparición de la enfermedad a consecuencia del desempeño del trabajo. Los sectores laborales de riesgo por enfermedades por anisakis, son los pescadores, pescaderos ("pescateros" y cocineros. En general todos aquellos que trabajan tanto en la captura, limpieza, manipulación, venta

  1. CaMKII determines mitochondrial stress responses in heart

    Science.gov (United States)

    Joiner, Mei-ling A.; Koval, Olha M.; Jingdong, Li; He, B. Julie; Allamargot, Chantal; Gao, Zhan; Luczak, Elizabeth D.; Hall, Duane D.; Fink, Brian D.; Chen, Biyi; Yang, Jinying; Moore, Steven A.; Scholz, Thomas D.; Strack, Stefan; Mohler, Peter J.; Sivitz, William I.; Song, Long-Sheng; Anderson, Mark E.

    2012-01-01

    Myocardial cell death is initiated by excessive mitochondrial Ca2+ entry, causing Ca2+ overload, mitochondrial permeability transition pore (mPTP) opening and dissipation of the mitochondrial inner membrane potential (ΔΨm)1,2. However, the signaling pathways that control mitochondrial Ca2+ entry through the inner membrane mitochondrial Ca2+ uniporter (MCU)3–5 are not known. The multifunctional Ca2+ and calmodulin-dependent protein kinase II (CaMKII) is activated in ischemia reperfusion (I/R), myocardial infarction (MI) and neurohumoral injury, common causes of myocardial death and heart failure, suggesting CaMKII could couple disease stress to mitochondrial injury. Here we show that CaMKII promotes mPTP opening and myocardial death by increasing MCU current (IMCU). Mitochondrial-targeted CaMKII inhibitory protein or cyclosporin A (CsA), an mPTP antagonist with clinical efficacy in I/R injury6, equivalently prevent mPTP opening, ΔΨm deterioration and diminish mitochondrial disruption and programmed cell death in response to I/R injury. Mice with myocardial and mitochondrial-targeted CaMKII inhibition are resistant to I/R injury, MI and neurohumoral injury, suggesting pathological actions of CaMKII are substantially mediated by increasing IMCU. Our findings identify CaMKII activity as a central mechanism for mitochondrial Ca2+ entry and suggest mitochondrial-targeted CaMKII inhibition could prevent or reduce myocardial death and heart failure dysfunction in response to common experimental forms of pathophysiological stress. PMID:23051746

  2. Bioetanol de la caña de azúcar

    Directory of Open Access Journals (Sweden)

    N. Aguilar-Rivera

    2007-01-01

    Full Text Available La búsqueda de la viabilidad y desarrollo de la agroindustria de la caña de azúcar es ya una política imperativa. La producción de caña y azúcar constituyen la principal agroindustria del país, con presencia en 57 ingenios azucareros, localizados en 15 estados de la república. Sin embargo, la actual ineficiencia productiva, altos costos y otras causas —como la entrada de jarabe de maíz de alta fructosa (HFCS de menor costo— han desplazado el consumo interno de azúcar de caña, principalmente en bebidas embotelladas. Todos estos factores han contribuido a la actual y prolongada crisis del sector azucarero. Por lo tanto, la industria debe reestructurarse y reducir la producción de azúcar hacia la competitividad, con la alternativa del etanol combustible en la búsqueda de un futuro para la industria azucarera en México. Con la producción de etanol (EtOH a gran escala, por parte de los ingenios azucareros, es posible visualizar un nuevo y futuro mercado de uso de energías renovables en México, oportunidades para la exportación e incrementar los beneficios ambientales y económicos a través de su uso. La flexibilidad de la producción combinada, de azúcar y etanol en los ingenios, permitirá alcanzar esquemas y objetivos ambientales como nación. Para la industria azucarera, su mayor competidesafío, en este sentido, representa disminuir los costos actuales de producción de etanol a través del uso de la ingeniería genética, uso de diferentes materias primas y la totalidad de la planta de caña de azúcar e introducir mejoras tecnológicas.

  3. Las motivaciones como factor clave de la conducta turística. Un estudio empírico en el Sureste Español

    OpenAIRE

    Beltrán Bueno, Miguel Ángel

    2014-01-01

    En estos tiempos de fuertes caídas en la demanda interna, la inversión y el gasto público, el sector turístico español ha mantenido extraordinariamente bien las cifras de empleo y de ingresos. Esto significa que, se trata de un sector muy estratégico y ha provocado que tanto empresas como instituciones públicas muestren un mayor interés por el mismo y lo conviertan en una alternativa sólida para el crecimiento y desarrollo de determinadas regiones o áreas geográficas. Desde una perspe...

  4. Producción de hidrocarburos biológicos utilizando un subproducto agroalimentario como sustrato. Production of biological hydrocarbons using and agrifood product as a sustrate

    OpenAIRE

    Barrows, Kesia; Abrego, Ubaldo; Ureña, Grimaldo; Franco, Indira

    2015-01-01

    La melaza es el residuo agroindustrial que no cristaliza resultante del procesamiento de la caña en la obtención de azúcar refinada. Tiene una amplia gama de usos destacándose, en el país, el dado en la alimentación bovina. Sin embargo, actualmente con el problema de la sostenibilidad energética el hombre debe encontrar alternativas de fuentes que sean renovables, principalmente el área de combustibles líquidos para el sector transporte y se podría encontrar una alternativa en la melaza como ...

  5. CaWRKY22 Acts as a Positive Regulator in Pepper Response to Ralstonia Solanacearum by Constituting Networks with CaWRKY6, CaWRKY27, CaWRKY40, and CaWRKY58

    OpenAIRE

    Ansar Hussain; Xia Li; Yahong Weng; Zhiqin Liu; Muhammad Furqan Ashraf; Ali Noman; Sheng Yang; Muhammad Ifnan; Shanshan Qiu; Yingjie Yang; Deyi Guan; Shuilin He

    2018-01-01

    The WRKY web, which is comprised of a subset of WRKY transcription factors (TFs), plays a crucial role in the regulation of plant immunity, however, the mode of organization and operation of this network remains obscure, especially in non-model plants such as pepper (Capsicum annuum). Herein, CaWRKY22, a member of a subgroup of IIe WRKY proteins from pepper, was functionally characterized in pepper immunity against Ralstonia Solanacearum. CaWRKY22 was found to target the nuclei, and its trans...

  6. Ab-initio calculations of the Ruddlesden-Popper phases CaMnO3, CaO(CaMnO3) and CaO(CaMnO3)2

    International Nuclear Information System (INIS)

    Cardoso, C; Borges, R P; Gasche, T; Godinho, M

    2008-01-01

    The present work reports ab-initio density functional theory calculations for the Ruddlesden-Popper phase CaO(CaMnO 3 ) n compounds. In order to study the evolution of the properties with the number of perovskite layers, a detailed analysis of the densities of states calculated for each compound and for several magnetic configurations was performed. The effect of distortions of the crystal structure on the magnetic ground state is also analysed and the exchange constants and transition temperatures are calculated for the three compounds using a mean field model. The calculated magnetic ground state structures and magnetic moments are in good agreement with experimental results and previous calculations

  7. Synthesis of Al₂Ca Dispersoids by Powder Metallurgy Using a Mg-Al Alloy and CaO Particles.

    Science.gov (United States)

    Fujita, Junji; Umeda, Junko; Kondoh, Katsuyoshi

    2017-06-28

    The elemental mixture of Mg-6 wt %Al-1 wt %Zn-0.3 wt %Mn (AZ61B) alloy powder and CaO particles was consolidated by an equal-channel angular bulk mechanical alloying (ECABMA) process to form a composite precursor. Subsequently, the precursor was subjected to a heat treatment to synthesize fine Al₂Ca particles via a solid-state reaction between the Mg-Al matrix and CaO additives. Scanning electron microscopy-energy-dispersive spectroscopy (SEM-EDS) and electron probe micro-analysis on the precursor indicated that 4.7-at % Al atoms formed a supersaturated solid solution in the α-Mg matrix. Transmission electron microscopy-EDS and X-ray diffraction analyses on the AZ61B composite precursor with 10-vol % CaO particles obtained by heat treatment confirmed that CaO additives were thermally decomposed in the Mg-Al alloy, and the solid-soluted Ca atoms diffused along the α-Mg grain boundaries. Al atoms also diffused to the grain boundaries because of attraction to the Ca atoms resulting from a strong reactivity between Al and Ca. As a result, needle-like (Mg,Al)₂Ca intermetallics were formed as intermediate precipitates in the initial reaction stage during the heat treatment. Finally, the precipitates were transformed into spherical Al₂Ca particles by the substitution of Al atoms for Mg atoms in (Mg,Al)₂Ca after a long heat treatment.

  8. Neomysin inhibits Ca2+-stimulated phosphatidylinositol hydrolysis and protects cultured rat cardiomyocytes from Ca2+-dependent cell injury

    International Nuclear Information System (INIS)

    Babson, J.R.; Dougherty, J.M.

    1991-01-01

    Exposure of cultured rat cardiomyocytes to ionomycin and extracellular Ca 2+ leads to a rapid, sustained increase in intracellular free Ca 2+ as monitored by Ca 2+ -dependent phosphorylase a activation and to a subsequent loss of cardiomyocyte viability as determined by lactate dehydrogenase (LDH) leakage. The intracellular free Ca 2+ increase coincided with a rapid hydrolysis of phosphatidylinositol that preceded cell death. Phosphatidylinositol hydrolysis was monitored by the release of radiolabeled phosphoinositides from cardiomyocytes prelabeled with [2- 3 H]-myo-inositol. Neomycin, a known inhibitor of phospholipase C, inhibited the phosphatidylinositol hydrolysis and markedly reduced the extent of cell injury. Inhibitors of other Ca 2+ -activated processes, including intracellular proteases and phospholipase A 2 , had no effect on ionomycin-mediated cell injury. These data suggest that ionomycin-induced Ca 2+ -dependent cell injury in cultured cardiomyocytes may be due in part to the stimulation of phosphatidylinositol hydrolysis, presumably catalyzed by a Ca 2+ -dependent phospholipase C

  9. O planejamento como prática do poder

    Directory of Open Access Journals (Sweden)

    Lucas Maia dos Santos

    2009-12-01

    Full Text Available

    Este texto visa apresentar uma leitura crítica acerca da prática de planejamento. Não é um esboço histórico, mas tão-somente uma interpretação do planejamento e como este está inserido na lógica de reprodução da sociedade capitalista. Argumenta para tanto que a prática de planejamento é realizada pela instituição estatal. Esta é um produto genuíno das sociedades de classes. O próprio estado tem como base social uma classe específica: a burocracia. Esta defende, dentro dos quadros da sociedade capitalista, os interesses gerais da burguesia, por mais que possa dentro de dadas circunstâncias sociais específicas opor-se a frações da burguesia, mas nunca aos interesses gerais de classe da burguesia. Defendemos que o poder é uma relação de dominação. Como tal, o planejamento é desta maneira uma manifestação da dominação de classe através da regulação do estado. A instituição estatal é desta forma responsável tanto por regularizar a prática do planejamento, quanto em muitos casos executar os planos ela própria. Assim, defende-se neste texto a necessidade de se superar as relações sociais que engendram o planejamento viabilizado pelo estado. Suprime-se assim o próprio planejamento.

  10. Etnografia como prática e experiência

    Directory of Open Access Journals (Sweden)

    José Guilherme Cantor Magnani

    2009-12-01

    Full Text Available Este artigo, a partir de alguns usos pouco ortodoxos da etnografia, fora do campo da antropologia, propõe uma discussão sobre a especificidade desse método de pesquisa, com base em pesquisas e reflexões realizadas sobre o tema no Núcleo de Antropologia Urbana da USP (NAU. Tomando como ponto de partida uma citação de Lévi-Strauss, repassa alguns autores - Goldman, Peirano, DaMatta, Favret-Saada, entre outros - para estabelecer parâmetros na busca de traços que considera específicos do fazer etnográfico e assim chega a três considerações principais: etnografia como experiência, como prática e com base numa certa noção de totalidade. O relato de uma etnografia sobre jovens surdos é apresentado para oferecer um suporte empírico àquelas conclusões.Considering some less orthodox uses of ethnography, not belonging to the anthropological field, this article proposes a discussion on the specificities of the ethnographical research method, based on reflections and researches undertaken at the Urban Anthropology Nucleus (NAU. Taking a Lévi-Strauss's quotation as its starting point, it examines the ideas of authors like Goldman, Peirano, Da Matta, Favret-Saada, among others, in order to establish parameters to guide the search for specific features in the ethnographic métier. Such a discussion leads to three considerations: ethnography as experience, as practice, and as based on a certain concept of "totality". The report of an ethnography on deaf young people is included in the article as empirical support to the conclusions.

  11. Cine interactivo como estrategia de intervención grupal

    Directory of Open Access Journals (Sweden)

    Paola Lauretti

    2009-05-01

    Full Text Available Utilizando el concepto de cine interactivo como agente motor de la relación inter e intra personal, presentamosuna experiencia con un grupo de adultos, con la finalidad de establecer el valor del cine como un recurso útil para laintervención grupal. El método de trabajo descriptivo se desarrolló en varias etapas: 1 aplicación del CuestionarioExploración de Necesidades (CEN del cual se extrajeron los principales temas a tratar; 2 selección, por parte delequipo de investigación, de aquellas películas que mejor se adaptaban a las necesidades detectadas; 3 aplicación delCuestionario Actitud frente al Cine (CAC para sus analizar su actitud antes de iniciar la experiencia; 4 proyecciónde las películas seleccionadas; 5 re aplicación del CAC dos meses después de culminado el proceso, para analizar loscambios operados con relación al cine. Los temas trabajados fueron relación de pareja y relaciones padres-hijos bajola utilización del modelo CAPAS el cual promueve el análisis de las situaciones planteadas en los siguientes pasos: C:comentario general del contenido; A: análisis del problema central; P: proceso de internalización; A: auto reflexión y S:Solución del conflicto. Los resultados apuntan hacia la importancia de considerar el cine como una estrategia valiosaen la intervención en grupos.

  12. AFINAL, COMO SE FORMAM AS ESTRATÃGIAS?

    Directory of Open Access Journals (Sweden)

    Maurício Fernandes Pereira

    2007-12-01

    Full Text Available Tem havido recentemente um grande interesse por parte dos autores em entender como se desenvolve a prática da estratégia organizacional. Partindo desta tendência, o presente trabalho descreve como ocorre o processo de formação estratégica em uma organização pertencente ao terceiro setor â o SESC/SC (Serviço Social do Comércio em Santa Catarina. A criação da estratégia na organização em estudo é analisada tomando-se como base os referenciais propostos por Whittington (2002, analisando duas dimensões principais: os resultados pretendidos com as estratégias e os processos pelos quais ela acontece. Com base nos dados coletados observou-se que, na prática da organização pesquisada, as razões que levam ao estabelecimento da estratégia não estão unicamente voltadas aos aspectos econômicos. Quanto à formação das estratégias, no caso estudado, predominou a formação da estratégia da visão clássica de Whittington (2002, por meio da utilização do planejamento estratégico.

  13. INTERPRETACIÓN CONSTITUCIONAL Y JUDICIAL. COMO LEER SENTENCIAS JUDICIALES

    Directory of Open Access Journals (Sweden)

    Sergio Rodríguez Alzate

    2010-01-01

    Full Text Available El Estado colombiano es un Estado social de derecho (así lo define el Artículo 1º de nuestra Carta Política, con el cual se busca la realización de la justicia social y la dignidad humana mediante la sujeción de las autoridades públicas a los principios, derechos y deberes sociales de orden constitucional. De allí, se desprende que sea tan importante el Derecho Constitucional, ya que es la principal rama del derecho público por cuanto participa en todos los estamentos propios de lo jurídico y especialmente de la estructura del Estado como base de todo ordenamiento institucional político, razón por la cual al entenderse como la disciplina del derecho encargada de los estudios conceptuales de los estados sociales de derecho, es vital tanto el surgimiento de la Constitución Política como de su interpretación, desde el estudio de sus fundamentos hasta la asimilación de una hermenéutica jurídica que encamine a todos los gobernados por la norma de normas. De acuerdo al concepto anteriormente señalado, se hace necesario valorar el alcance de la Interpretación Constitucional en el contexto general de la Carta Magna facilitando la exégesis judicial y su contenido crítico, llegando a una conexión explicativa de cualquier problema jurídico y extrajurídico.

  14. Mejoramiento de los procesos administrativos y de servicios en el Honorable Consejo Provincial del Cañar

    OpenAIRE

    Buestán Toral, José Remigio; Urgilés Pauta, Diego

    2006-01-01

    Como conclusión el autor manifiesta que el sistema organizacional del H. Consejo Provincial del Cañar, mantiene una estructura vertical, tadicional ya que está en función jerárquica, y no permite alcanzar efectividad y eficiencia en los principales procesos administrativos y operativos, a su vez imposibilita a sus servidores actuar en función del cliente, cumpliendo sus actividades en base a órdenes y prácticas institucionales que han sido repetitivas en cada administración

  15. Biomateriales utilizados en cirugía ortopédica como sustitutos del tejido óseo

    Directory of Open Access Journals (Sweden)

    Cristian Alexis Martinez

    2012-09-01

    Full Text Available El presente artículo analiza empleo de los biocerámicos en aplicaciones clínicas, como sustitutos óseos, desarrollos en Argentina y Europa, y los productos comerciales disponibles. Los cerámicos para este propósito son bioinertes, bioactivos o reabsorbibles. Estos se caracterizan por su biocompatibilidad, capacidad de degradación controlada, y liberación de iones biológicamente activos (Ca++ y PO4--- al medio fisiológico. Además, estos materiales presentan ventajas respecto al hueso de banco, tales como su disponibilidad, reproducibilidad de sus propiedades físicas, químicas y mecánicas; capacidad de absorción  y liberación paulatina de fármacos. Los biocerámicos constituyen un sustrato viable para cultivos celulares y el desarrollo de nuevas variantes de sustitutos óseos, que incorporen fases orgánicas.

  16. Reactivation of Rate Remapping in CA3.

    Science.gov (United States)

    Schwindel, C Daniela; Navratilova, Zaneta; Ali, Karim; Tatsuno, Masami; McNaughton, Bruce L

    2016-09-07

    The hippocampus is thought to contribute to episodic memory by creating, storing, and reactivating patterns that are unique to each experience, including different experiences that happen at the same location. Hippocampus can combine spatial and contextual/episodic information using a dual coding scheme known as "global" and "rate" remapping. Global remapping selects which set of neurons can activate at a given location. Rate remapping readjusts the firing rates of this set depending on current experience, thus expressing experience-unique patterns at each location. But can the experience-unique component be retrieved spontaneously? Whereas reactivation of recent, spatially selective patterns in hippocampus is well established, it is never perfect, raising the issue of whether the experiential component might be absent. This question is key to the hypothesis that hippocampus can assist memory consolidation by reactivating and broadcasting experience-specific "index codes" to neocortex. In CA3, global remapping exhibits attractor-like dynamics, whereas rate remapping apparently does not, leading to the hypothesis that only the former can be retrieved associatively and casting doubt on the general consolidation hypothesis. Therefore, we studied whether the rate component is reactivated spontaneously during sleep. We conducted neural ensemble recordings from CA3 while rats ran on a circular track in different directions (in different sessions) and while they slept. It was shown previously that the two directions of running result in strong rate remapping. During sleep, the most recent rate distribution was reactivated preferentially. Therefore, CA3 can retrieve patterns spontaneously that are unique to both the location and the content of recent experience. The hippocampus is required for memory of events and their spatial contexts. The primary correlate of hippocampal activity is location in space, but multiple memories can occur in the same location. To be useful

  17. Gamificación como estrategia de marketing interno

    OpenAIRE

    Ruizalba Robledo, José Luis; Navarro Lucena, Fernando; Jiménez Arenas, Sergio

    2013-01-01

    Objeto: Este estudio tiene como objetivos de una parte ofrecer elementos para crear un marco de referencia que permita la integración de la gamificación en las políticas de marketing interno y de otra analizar de manera descriptiva varios casos prácticos de empresa en los que se muestra el papel que la gamificación juega al implicar clientes y empleados con estrategias de engagement que influyan en sus comportamientos. Diseño/metodología/enfoque: Partiendo de la orientación al marketing i...

  18. El parentesco como sistema en la interfaz bio-cultural

    OpenAIRE

    G??mez Garc??a, Pedro

    2011-01-01

    Aqu??, he centrado mi investigaci??n en la descripci??n del sistema de parentesco humano como constituido por una organizaci??n espec??fica, en la que se opera una articulaci??n bio-cultural. El parentesco no consiste solo en elementos biol??gicos, o m??s exactamente gen??ticos, ni tampoco ??nicamente en los determinantes sociales o culturales. Las relaciones familiares se constituyen y desarrollan en la interfaz entre el plano biogen??tico y el sociocultural, dando lugar a la formaci??n del ...

  19. La tortilla como identidad culinaria y producto de consumo global

    OpenAIRE

    Margarita Calleja Pinedo; María Basilia Valenzuela

    2016-01-01

    Resumen: La tortilla forma parte de la identidad culinaria de los mexicanos que viven en México o en el extranjero; es un componente básico de los antojitos, acompaña a los platillos festivos y es un suministro consuetudinario en la comida. Desde la época colonial, españoles, indios y mexicanos produjeron en el norte del país una cultura culinaria, hoy conocida como tex-mex, que ha sido recreada por las olas constantes de migrantes, y aunque en México fue rechazada, en Estados Unidos y en el ...

  20. Purpura, verde, azul...la calidad como un color

    OpenAIRE

    Lorenzo Ramírez, Nuria

    2009-01-01

    El objetivo de este artículo es explicar, compartir y hacer públicos algunos pensamientos e ideas sobre la Universidad y la cultura del profesorado universitario. Se parte de la idea de que no existe armonía entre la gestión, la técnica y la cultura universitaria. Si como docentes aprendemos de la experiencia y del ambiente de trabajo, entonces cabe preguntarse por nuestras experiencias y por los conocimientos que a travcs de ellas hemos generado, para mantenerlos o rechazar...

  1. Los Balnearios como Centros de Salud Spas as health center

    Directory of Open Access Journals (Sweden)

    Manuel López Morales

    2004-03-01

    Full Text Available Los balnearios están siendo reconsiderados. Frente a estilos de vida lesivos para nuestra salud, y terapéuticas agresivas, se posicionan sólidamente las terapias naturales, como la crenoterapia. A ello contribuyen la emergencia de nuevos valores sociales relacionados con la salud. Se ofrece información técnica sobre las indicaciones y modalidades balneoterápicas.Spas are being reconsidered. Instead of unhealthy way of life and aggressive therapies, crenotherapy take sure place. The new demand for spas is a response to new values. We offer thecnics information above suitable indications and balneotherapy kinds.

  2. EL CUERPO COMO PARADIGMA TEÓRICO EN LITERATURA

    Directory of Open Access Journals (Sweden)

    Cándida Elizabeth Vivero Marín

    2008-01-01

    Full Text Available La teoría y la crítica literarias feministas toman como uno de sus ejes conceptuales al cuerpo, a fin de explicar el texto literario escrito principalmente por mujeres. Sin embargo, han dejado de lado un punto igualmente central: la función poética. Este artículo trata de traer de nueva cuenta, a la mesa de la discusión teórica, la necesidad de llegar a un equilibrio entre la función comunicativa y la función poética inherentes al texto literario.

  3. La responsabilidad social corporativa como eje de desarrollo sostenible

    OpenAIRE

    Bravo, Gissela; Plaza, Nila

    2013-01-01

    La responsabilidad social corporativa (RSC), también denominada por algunos autores como Responsabilidad Social Empresarial (RSE), es voluntaria y se sustenta en la ética. Considerar que debe ser así, para que las empresas realicen actividades limpias sin necesidad de implementar medidas desde la normativa legal. Las empresas tienen obligaciones morales con sus clientes internos, externos y la comunidad a la que se debe. Todos los propósitos de la empresa son logrados por estos grupos de inte...

  4. El conflicto familiar como fuente embrionaria de violencia social

    Directory of Open Access Journals (Sweden)

    Juan Carlos Santa Cruz

    1999-02-01

    Full Text Available Este artículo es el resultado de un estudio realizado entre 120 familias de la ciudad de Managua. La investigación revela que el ejercicio del poder en la vida familiar tiene un evidente sesgo vertical que apunta hacia el autoritarismo. En gran parte de los testimonios, se reconoce que predomina o han predominado formas violentas en la resolución de conflictos, particularmente entre padres e hijos. El conflicto, como tal, no se resuelve en el corto plazo, sino que se posterga. Mientras en el mediano plazo, favorece ciertas incertidumbres que alimentan una fuente embrionaria de violencia social.

  5. La equidad como propósito del desarrollo

    Directory of Open Access Journals (Sweden)

    Corredor Consuelo

    1995-06-01

    Full Text Available Los nocivos efectos sociales de la política seguida en el cuatrenio anterior, la persistencia de diferentes formas de violencia y el potencial democrático de la Constitución Política, que otorga un lugar central a lo social, son factores objetivos que explican la propuesta formulada en el plan de desarrollo El Salto Social, así como las expectativas y el respaldo de la opinión pública a algunas de sus iniciativas.

  6. La cultura de masas como el nuevo opio del pueblo

    OpenAIRE

    Correa García, Ramón Ignacio; Martínez Mojarro, Mª Eugenia; Martínez Mojarro, Natalia

    2001-01-01

    La cultura de masas, así como otros sistemas doctrinarios que forman parte de la vida de los ciudadanos de la sociedad actual conforman reglas de pensamiento y estilos de vida. Los autores plantean una reflexión sobre la hegemonía incontestable de los Estados Unidos y llega a la conclusión de que una realidad impuesta sutilmente consigue anestesiar la conciencia crítica de las personas a la vez que impide ver otras realidades. La cuestión final a la que se abre esta colaboración es la que se ...

  7. El duelo anticipatorio del anciano como paciente terminal

    OpenAIRE

    Ospina Velasco, Ana María

    2012-01-01

    El presente artículo tiene como objetivo ilustrar, a partir de un caso observado, algunos elementos teóricos de la literatura tanatológica , sobre el proceso de duelo del anciano enfermo, frente a la inminencia de su muerte. La clínica relacionada con aspectos del proceso de muerte, ha permitido identificar elementos o variables comunes, inherentes a dicho proceso, que son vivenciados en forma específica por los individuos, de acuerdo precisamente con sus características particul...

  8. A violência escolar como regime de visibilidade

    OpenAIRE

    Forero Londoño, Oscar Fernando; Universidad Distrital Francisco José de Caldas

    2012-01-01

    Resumen Este escrito aborda los discursos sobre la violencia escolar y los asume como regímenes de visibilidad que se construyen históricamente. Además, expone de manera esquemática cómo son asumidas las nociones de ju- ventud, cultura escolar y cultura juvenil en los estudios sobre la violencia escolar.Reflexionar sociológicamente sobre las diversas formas de definir la vio- lencia escolar y su relación con las poblaciones en condición juvenil implica asumir que las determinaciones analítica...

  9. EL PROFESOR COMO GESTOR DEL PROCESO ACADÉMICO

    Directory of Open Access Journals (Sweden)

    María Morella Colls Carrillo

    2013-03-01

    Full Text Available El presente estudio tiene como objetivo abordar los procesos de cambio que están ocurriendo en la educación superior, y el papel del profesor universitario como gestor del conocimiento en entorno del aprendizaje. En tal sentido, se analizan y discuten las percepciones de un grupo de profesores de la Universidad Nacional Experimental Simón Rodríguez en torno de las tecnologías de la información y de la comunicación (TICs y los cambios que genera su implementación en los procesos de enseñanza y del aprendizaje. El escenario es los cambios que se generan con la implementación de las tecnologías de la información y de la comunicación en los procesos de enseñanza aprendizaje. El resultado de esta investigación se traducirá en las interpretaciones conceptuales y teóricas que darán soporte a la conceptualización conforme a la nueva visión expresada en el marco legal que la fundamenta y en su pertinencia social. Como aporte se espera generar constructos teóricos sobre la actuación del profesor como gestor universitario.PALABRAS CLAVE: conocimiento; educación; comunicación; TICsTHE TEACHER AS AGENT OF THE ACADEMIC PROCESS  ABSTRACTThe present study has as objective to approach the processes of change that are happening in the superior education, and the university professor's paper as agent of the knowledge in environment of the learning. In such a sense, they are analyzed and the perceptions of a group of professors of the National Experimental University name after Simón Rodríguez in lathe of the information and of the communication technologies (ICT and the changes that generates their implementation in the teaching and learning processes. The scenario is the changes that are generated with the implementation of the technologies of the information and of the communication in the processes of teaching learning. The result of this investigation will be translated in the conceptual and theoretical interpretations that will give

  10. La violencia como estrategia, para formar liderazgo estudiantil

    OpenAIRE

    Hurtado, Eladia

    2012-01-01

    La violencia se ha trasformado en un problema de salud pública, según la asamblea Mundial de la Salud, (AMS) en el año (1996), acrecentándose en Venezuela la violencia estudiantil. La cual se ha convertido en tema de interés en los últimos años, el índice de mismo, pareciera propagarse cada día. Motivo por el cual se presenta la siguiente investigación de tipo fenomenológica de campo descriptiva, con variable como: Estrato social, consumo de alcohol o droga, consumo de cigarrillo, comunicació...

  11. Reflexos de sangue: Dracula como espelho da era vitoriana tardia

    OpenAIRE

    Marques, Cátia Sofia Guedes

    2010-01-01

    Tese de mestrado, Ciências da Cultura, Universidade de Lisboa, Faculdade de Letras, 2011 Partindo dos conhecimentos adquiridos no curso de Ciências da Cultura, esta dissertação é produto da articulação entre um documento cultural importante, como um grande clássico da literatura inglesa, Dracula, e o respectivo estudo segundo a perspectiva sociológica das Ciências Sociais. Utilizando os conceitos de género, status, classe social e representação, é possível analisar se as quatro personag...

  12. La acedia como forma de malestar en la sociedad actual

    Directory of Open Access Journals (Sweden)

    María Lucrecia Rovaletti

    2014-03-01

    Full Text Available Partiendo de la propuesta de Theunissen, se busca realizar un regreso arqueológico respecto al concepto de melancolía en la antigüedad y de acedia medieval. Con ello, se intenta reflexionar esa trama de fatiga, aburrimiento, tedio, tristeza que se entreteje en la cultura actual. Charbonneau y Legrand (2003 designan como paradepresiones a este conjunto de problemas a menudo infrasintomáticos, demasiado lábiles y poco significativos para ser denominados síntomas.

  13. “Casa Elina”: el encuentro como oportunidad

    OpenAIRE

    Saavedra, Caudia; Martinez Goya, Milagros

    2017-01-01

    El dispositivo “Casa Elina” nace en abril del año 2014, como un servicio integrado entre el Hospital Subzonal Especializado “Elina de la Serna de Montes de Oca” y la Subsecretaría de Salud Mental y Adicciones, ahora Subsecretaría de Determinantes Sociales de la Salud y la Enfermedad Física, Mental y de las Adicciones del Ministerio de Salud de la provincia de Buenos Aires. Surge con la impronta de ser un dispositivo innovador en relación al formato tradicional hospitalario, a la vez de encuad...

  14. O ENSINO DA FILOSOFIA COMO UMA TECNOLOGIA DE GOVERNAMENTALIDADE

    OpenAIRE

    Oliveira, Liliana Souza de

    2016-01-01

    * Doutora em Educação pela Universidade Federal de Santa Maria (UFSM). Professora de Filosofia no Instituto Federal Farroupilha-Campus São Vicente do Sul/RS.O ensino da filosofia como uma tecnologia de governamentalidadeResumo: O presente trabalho insere-se nas discussões sobre o ensino da Filosofia. Pretendo a partir de uma inspiração foucaultiana analisar as condições de emergência do discurso sobre a importância da Filosofia no vestibular da Universidade Federal de Santa Maria (UFSM) e as ...

  15. Las modificaciones estructurales como parte del proceso concursal

    OpenAIRE

    Giron Beckles, Jessica

    2013-01-01

    La investigación propuesta se centra en el estudio de las modificaciones estructurales de sociedades, reguladas por la Ley 3/2009 de 3 de abril, dentro del proceso concursal y tiene como propósito el realizar una labor de hermenéutica jurídica con el fin de sentar las bases para la armonización del Derecho de Sociedades y el Derecho concursal en torno al problema planteado. Busca sistematizar y dar solución a las preguntas que surgen cuando confluyen estas dos regulaciones, mediante el anális...

  16. La convergencia como oportunidad para mejorar la docencia universitaria

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    Miguel Angel ZABALZA BERAZA

    2006-01-01

    Full Text Available El proceso de convergencia hacia el EEES ha supuesto la incorporación de nuevos referentes académicos y culturales en nuestras universidades. Este artículo trata de centrarse en el análisis de aquellos que tienen que ver con la docencia y tienen como objetivo su mejora. Se analizan especialmente cinco de ellos: el aprendizaje autónomo; el modelo de formación basado en competencias; la consideración del tiempo y la carga de trabajo en los ECTS; el enfoque curricular de las enseñanzas y, finalmente, el lifelong learning.

  17. Fitoterapia como coadyuvante en el tratamiento de la obesidad

    OpenAIRE

    López-Regueiro, Sofía; Ramos Sáiz, Eva María; López-Picado, Amanda; Burgos-Alonso, Natalia; Arana-Salaberría, Ainara

    2012-01-01

    La obesidad es uno de los problemas de salud más importantes a nivel mundial debido a su relación con numerosas patologías como la diabetes mellitus tipo 2, la hipertensión y el aumento importante en el riesgo cardiovascular. La base del tratamiento es la dieta y el ejercicio físico, pero en muchos casos no es sufi ciente y es necesario combinarlo con tratamiento farmacológico. Recientemente se ha retirado sibutramina del mercado por lo que sólo se dispone de orlistat, que no está exento de c...

  18. Falares: a oralidade como elemento construtor da grande-reportagem

    OpenAIRE

    Alex Criado

    2006-01-01

    Esta tese discute a incorporação da oralidade de falantes excluídos social e culturalmente na grande-reportagem. O foco desta pesquisa é refletir como a grande-reportagem no Brasil, em sua missão de desvendamento do real, tem lidado com a questão da oralidade. Discute os desafios para a incorporação dos registros orais de pessoas com baixa escolaridade, tendo em vista o preconceito que existe na sociedade em relação aos falantes que se utilizam de modalidades diferentes da língua padrão. Prop...

  19. La ciudad como proceso de comunicación

    Directory of Open Access Journals (Sweden)

    Javier Esteinou Madrid

    2015-01-01

    Full Text Available El autor presenta algunos elementos que ayudarán a la comprensión del fenómeno comunicación-ciudad en los tiempos de la modernidad latinoamericana. Al final del siglo XX, el principal espacio donde se concentra la población de América Latina y del resto del planeta es en las ciudades, por lo que se debe estar obligado a retomar la realidad comunicación-ciudad como una prioridad para analizar y transformar dentro del ámbito de las políticas nacionales de comunicación.

  20. Revisión entre pares como instrumento de aprendizaje

    OpenAIRE

    Crespo García, Raquel; Villena Román, Julio

    2005-01-01

    Proyecto de Innovación Docente en las asignaturas de Organización de Contenidos Audiovisuales y e Inteligencia en Redes de Comunicaciones Este artículo describe la experiencia de innovación docente llevada a cabo este último curso basada en la aplicación de la metodología de revisión entre iguales como instrumento para el aprendizaje, desarrollada en las asignaturas Organización de Contenidos Audiovisuales (Ingeniería Técnica de Telecomunicación, especialidad Sonido e Imagen) durante el cu...