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Sample records for c8 diazocine turn

  1. 26 CFR 301.6231(c)-8 - Prompt assessment.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Prompt assessment. 301.6231(c)-8 Section 301.6231(c)-8 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) PROCEDURE AND ADMINISTRATION PROCEDURE AND ADMINISTRATION Assessment In General § 301.6231(c)-8 Prompt assessment. (a) In general. The treatment of items as...

  2. A general synthesis of C8-arylpurine phosphoramidites.

    Science.gov (United States)

    Vongsutilers, Vorasit; Daft, Jonathan R; Shaughnessy, Kevin H; Gannett, Peter M

    2009-09-02

    A general scheme for the synthesis of C8-arylpurine phosphoramidites has been developed. C8-Arylation of C8-bromo-2'-deoxyguanosine is the key step and has been achieved through the use of a Suzuki coupling. Since the coupling reaction is conducted under aqueous conditions, it is unnecessary to protect and then deprotect the hydroxyl groups, thus saving several steps and improving overall yields. Once the C8-arylgroup is introduced, the glycosidic bond becomes very sensitive to acid catalyzed cleavage. Protection of the amino groups as the corresponding N,N-dimethylformamidine derivative improves stability of the derivatives. Synthetic C8-arylpurines were successfully used to prepare synthetic oligonucleotides.

  3. A General Synthesis of C8-Arylpurine Phosphoramidites

    Directory of Open Access Journals (Sweden)

    Vorasit Vongsutilers

    2009-09-01

    Full Text Available A general scheme for the synthesis of C8-arylpurine phosphoramidites has been developed. C8-Arylation of C8-bromo-2′-deoxyguanosine is the key step and has been achieved through the use of a Suzuki coupling. Since the coupling reaction is conducted under aqueous conditions, it is unnecessary to protect and then deprotect the hydroxyl groups, thus saving several steps and improving overall yields. Once the C8-arylgroup is introduced, the glycosidic bond becomes very sensitive to acid catalyzed cleavage. Protection of the amino groups as the corresponding N,N-dimethylformamidine derivative improves stability of the derivatives. Synthetic C8-arylpurines were successfully used to prepare synthetic oligonucleotides.

  4. Taking Turns

    Science.gov (United States)

    Hopkins, Brian

    2010-01-01

    Two people take turns selecting from an even number of items. Their relative preferences over the items can be described as a permutation, then tools from algebraic combinatorics can be used to answer various questions. We describe each person's optimal selection strategies including how each could make use of knowing the other's preferences. We…

  5. Turned on/turned off

    DEFF Research Database (Denmark)

    Petersen, Eva Bendix

    2016-01-01

    position, it attempts to sense into the lived experience of being subject to, and of, turns in social theory. As a whole the paper seeks to work with and allow for multiplicity in tone, focus, researcher positioning, reader positioning, and more, to see what knowledge that does not seek confident closure...

  6. Tight Turns

    Directory of Open Access Journals (Sweden)

    Jenifer Sutherland

    2013-01-01

    Full Text Available The plain text was task-oriented in a roundabout way, providing detailed instructions for how NOT to build an elaborate sequence of bridges, each one bound to produce, according to chapters one through twenty-three, disastrous results. Graphic novels disguised as illuminated letters twisted the tent-dwelling decipherer into painful self-recognition. The flashlight followed the phases of the moon. Meanwhile one strand of marginalia, written in anxious back-slant, pleaded for some kind of adjustable form for managing the confluence, especially during flood season. I like what we came up with. 'We' is a little big word. In fact the tent turns out to be one of those Borgesian core-tech structures allowing for astonishing internal expansion. There's not much we didn't get in there and not much in there that didn't get us. So I suppose that's it. This tent. This confluence. These children who found me here, turned text into life and made life home.

  7. Preparation, characterization and biological activity of C8-substituted cytokinins.

    Science.gov (United States)

    Zahajská, Lenka; Nisler, Jaroslav; Voller, Jiří; Gucký, Tomáš; Pospíšil, Tomáš; Spíchal, Lukáš; Strnad, Miroslav

    2017-03-01

    Naturally occurring cytokinins are adenine-based plant hormones. Although, the effect of various substituents at positions N1, C2, N3, N6, N7, or N9 on the biological activity of cytokinins has been studied, the C8-substituted compounds have received little attention. Here, we report the synthesis and in vitro biological testing of thirty-one cytokinin derivatives substituted at the C8 position of the adenine skeleton and twenty-seven compounds which served as their N9-tetrahydropyranyl protected precursors. The cytokinin activity of all the compounds was determined in classical cytokinin biotests (wheat leaf senescence, Amaranthus and tobacco callus assays). With some exceptions, the compounds with a N9-tetrahydropyranyl group were generally less active than their de-protected analogs. The latter were further tested for their ability to activate the Arabidopsis cytokinin receptors AHK3 and CRE1/AHK4 in bacterial receptor activation assays. Using this approach, we identified derivatives bearing short aliphatic chains and retaining high cytokinin activity. Such compounds are suitable candidates for fluorescence labeling or as protein-affinity ligands. We further found that some C8-substituted cytokinins exhibited no or lower cytotoxicity toward tobacco cells when compared to their parent compound. Therefore, we also present and discuss the cytotoxicity of all the compounds against three normal human cell lines. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Role of cytochrome P450 2C8*3 (CYP2C8*3) in paclitaxel metabolism and paclitaxel-induced neurotoxicity

    DEFF Research Database (Denmark)

    Lee, Mi-Young; Apellániz-Ruiz, María; Johansson, Inger

    2015-01-01

    AIM: The CYP2C8*3 allele has been suggested as a risk factor for paclitaxel-induced neuropathy but the data hitherto published are conflicting. MATERIALS & METHODS: In total 435 patients were investigated with respect to maximum neuropathy grade and accumulated paclitaxel dose. The enzymatic...... properties of CYP2C8.3 variant were analyzed using heterologous mammalian HEK293 cell expression system. RESULTS: No significant association between CYP2C8*3 allele and neuropathy was found, although a trend was observed. The paclitaxel and amodiaquine metabolism by CYP2C8.3 were found similar to CYP2C8.......1, whereas CYP2C8.3 was more efficient in the metabolism of rosiglitazone. CONCLUSION: These results indicate a difference in substrate specificity between CYP2C8.1 and CYP2C8.3; however, the CYP2C8*3 allele has no major impact on paclitaxel metabolism in vitro or of paclitaxel-induced neuropathy in vivo...

  9. 26 CFR 1.381(c)(8)-1 - Installment method.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Installment method. 1.381(c)(8)-1 Section 1.381(c)(8)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Insolvency Reorganizations § 1.381(c)(8)-1 Installment method. (a) Carryover...

  10. Nqrs Data for C8H9LiO6 [C8H5LiO4·2(H2O)] (Subst. No. 1093)

    Science.gov (United States)

    Chihara, H.; Nakamura, N.

    This document is part of Subvolume A `Substances Containing Ag … C10H15' of Volume 48 `Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III `Condensed Matter'. It contains an extract of Section `3.2 Data tables' of the Chapter `3 Nuclear quadrupole resonance data' providing the NQRS data for C8H9LiO6 [C8H5LiO4·2(H2O)] (Subst. No. 1093)

  11. The Digital Turn

    NARCIS (Netherlands)

    Westera, Wim

    2013-01-01

    Westera, W. (2013, 22 May). The Digital Turn. How the internet transforms our existence. Invited presentation at the symposium "Onderwijsvernieuwen in crisistijd", Heerlen, The Netherlands: Open Universiteit.

  12. 75 FR 8796 - Civil Penalties Under ERISA Section 502(c)(8)

    Science.gov (United States)

    2010-02-26

    ... Section 502(c)(8) AGENCY: Employee Benefits Security Administration, Labor. ACTION: Final rule. SUMMARY... civil penalties by the Department of Labor under section 502(c)(8) of the Employee Retirement Income... model notice for plans in critical status. See 73 FR 15688 (Mar. 25, 2008). However, section 102(b)(1)(C...

  13. Review Essay: Turn, Turn, Turn Around—Till Categories Blur

    Directory of Open Access Journals (Sweden)

    Lars Allolio-Näcke

    2008-01-01

    Full Text Available I begin this review by introducing the book and discussing its manifest content chapter by chapter (see 2.1, focusing particularly on the author's argumentation concerning the development of new orientations in cultural studies and on how, in relation to the turns discussed, the names of the researchers and central categories involved are collected. In a second step, I give a close reading of the book's latent content, which I consider to be more important (see 2.2. In this context I discuss several questions of scientific politics—especially the issue of hegemonic claims. Thirdly, I read the book from the critical standpoint of a psychologist, a sociologist and a theologian and show the shortcomings of BACHMANN-MEDICK's outsider perspective on these disciplines. In this regard I read the book again and provide a critique of the quality of the author's scientific performance (see 3. Finally, I state the reasons I do not recommend reading this book (see 4. URN: urn:nbn:de:0114-fqs0801266

  14. C8 cross transfer for the treatment of caudal brachial plexus avulsion in three dogs.

    Science.gov (United States)

    Moissonnier, Pierre; Carozzo, Claude; Thibaut, Jean-Laurent; Escriou, Catherine; Hidalgo, Antoine; Blot, Stéphane

    2017-01-01

    To evaluate the cervical nerve 8 cross-transfer technique (C8CT) as a part of surgical treatment of caudal brachial plexus avulsion (BPA) in the dog. Case series. Client-owned dogs suspected to have caudal BPA based on neurological examination and electrophysiological testing (n = 3). The distal stump of the surgically transected contralateral C8 ventral branch (donor) was bridged to the proximal stump of the avulsed C8 ventral branch (recipient) and secured with 9-0 polypropylene suture under an operating microscope. A carpal panarthrodesis was performed on the injured limb after C8CT. Surgical exploration confirmed avulsion of nerve roots C7, C8, and T1 in all cases. There was no evidence of an iatrogenic effect on the donor forelimb. Gradual improvement in function of the affected forelimb occurred in all dogs, with eventual recovery of voluntary elbow extension. Reinnervation was evident in EMG recordings 6 months postoperatively in all three dogs. Stimulation of the donor C8 ventral branch led to motor evoked potentials in the avulsed side triceps brachialis and radial carpus extensor muscles. Variable functional outcome was observed in the 3 dogs during clinical evaluation 3-4 years after surgery. Digital abrasion wounds, distal interphalangeal infectious arthritis, and self-mutilation necessitated distal phalanx amputation of digits 3 and 4 in 2 dogs. C8CT provided partial reconnection of the donor C8 ventral branch to the avulsed brachial plexus in the 3 dogs of this series. Reinnervation resulted in active elbow extension and promoted functional recovery in the affected limb. © 2017 The American College of Veterinary Surgeons.

  15. Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development.

    Science.gov (United States)

    Simeone, A; Mavilio, F; Acampora, D; Giampaolo, A; Faiella, A; Zappavigna, V; D'Esposito, M; Pannese, M; Russo, G; Boncinelli, E

    1987-07-01

    Two human cDNA clones (HHO.c1.95 and HHO.c8.5111) containing a homeobox region have been characterized, and the respective genomic regions have been partially analyzed. Expression of the corresponding genes, termed c1 and c8, was evaluated in different organs and body parts during human embryonic/fetal development. HHO.c1.95 apparently encodes a 217-amino acid protein containing a class I homeodomain that shares 60 out of 61 amino acid residues with the Antennapedia homeodomain of Drosophila melanogaster. HHO.c8.5111 encodes a 153-amino acid protein containing a homeodomain identical to that of the frog AC1 gene. Clones HHO.c1 and HHO.c8 detect by blot-hydridization one and two specific polyadenylylated transcripts, respectively. These are differentially expressed in spinal cord, backbone rudiments, limb buds (or limbs), heart, and skin of human embryos and early fetuses in the 5- to 9-week postfertilization period, thus suggesting that the c1 and c8 genes play a key role in a variety of developmental processes. Together, the results of the embryonic/fetal expression of c1 and c8 and those of two previously analyzed genes (c10 and c13) indicate a coherent pattern of expression of these genes in early human ontogeny.

  16. Hydrodynamics of Turning Flocks.

    Science.gov (United States)

    Yang, Xingbo; Marchetti, M Cristina

    2015-12-18

    We present a hydrodynamic model of flocking that generalizes the familiar Toner-Tu equations to incorporate turning inertia of well-polarized flocks. The continuum equations controlled by only two dimensionless parameters, orientational inertia and alignment strength, are derived by coarse-graining the inertial spin model recently proposed by Cavagna et al. The interplay between orientational inertia and bend elasticity of the flock yields anisotropic spin waves that mediate the propagation of turning information throughout the flock. The coupling between spin-current density to the local vorticity field through a nonlinear friction gives rise to a hydrodynamic mode with angular-dependent propagation speed at long wavelengths. This mode becomes unstable as a result of the growth of bend and splay deformations augmented by the spin wave, signaling the transition to complex spatiotemporal patterns of continuously turning and swirling flocks.

  17. Controlling of the optical properties of the solutions of the PTCDI-C8 organic semiconductor

    Science.gov (United States)

    Erdoğan, Erman; Gündüz, Bayram

    2016-09-01

    N,N'-Dioctyl-3,4,9,10 perylenedicarboximide (PTCDI-C8) organic semiconductor have vast applications in solar cells, thermoelectric generators, thin film photovoltaics and many other optoelectronic devices. These applications of the materials are based on their spectral and optical properties. The solutions of the PTCDI-C8 for different molarities were prepared and the spectral and optical mesaurements were analyzed. Effects of the molarities on optical properties were investigated. Vibronic structure has been observed based on the absorption bands of PTCDI-C8 semiconductor with seven peaks at 2.292, 2.451, 2.616, 3.212, 3.851, 4.477 and 4.733 eV. The important spectral parameteres such as molar/mass extinction coefficients, absorption coefficient of the PTCDI-C8 molecule were calculated. Optical properties such as angle of incidence/refraction, optical band gap, real and imaginary parts of dielectric constant, loss factor and electrical susceptibility of the the PTCDI-C8 were obtained. Finally, we discussed these parameters for optoelectronic applications and compared with related parameters in literature.

  18. Turning lead into gold

    DEFF Research Database (Denmark)

    Jensen, Steffen Moltrup Ernø

    For years the field of entrepreneurship has been blinded by the alchemical promise of turning lead into gold, of finding the ones most likely to become the next Branson, Zuckerberg or Gates. The promise has been created in the midst of political and scientific agendas where certain individuals...

  19. Turning Desirements into Requirements

    Science.gov (United States)

    2015-09-01

    carrier op- erations now leads to the two additional requirements to limit aircraft weight and limit aircraft size. A vivid example involves a missile...with worthy performance. None of these communications steps are easy. The abilities to innovate and to imagine often begin tortuous processes to turn

  20. Structural analysis of the indium-stabilized GaAs(001)-c(8×2) surface

    DEFF Research Database (Denmark)

    Lee, T.-L.; Kumpf, C.; Kazimirov, A.

    2002-01-01

    The indium-stabilized GaAs(001)-c(8x2) surface was investigated by surface x-ray diffraction and x-ray standing waves. We find that the reconstruction closely resembles the c(8x2) structure described by the recently proposed unified model for clean III-V semiconductor surfaces [Kumpf , Phys. Rev...... different due to the lateral strain induced by the lattice mismatch. This structural difference explains why the ladder-type pattern observed previously by scanning tunneling microscopy only appears for the In/GaAs(001) and InAs/GaAs(001) surfaces, but not for the InAs clean surface. The structural model we...... propose for the In-stabilized GaAs(001)-c(8x2) surface, which fully agrees with the scanning tunneling microscopy results, should therefore generally apply to strained InAs(001) surfaces....

  1. Impact of CYP2C8*3 on paclitaxel clearance in ovarian cancer patients

    DEFF Research Database (Denmark)

    Bergmann, Troels Korshøj; Vach, Werner; Gréen, Henrik

    Background Toxicity and therapeutic effects of paclitaxel vary greatly between patients and remain a clinically relevant problem with regard to the handling of dose delay/reduction or termination of treatment. We investigated the notion that single nucleotide polymorphisms (SNPs) in CYP2C8 could...... be partly responsible for this variation. Paclitaxel is mainly metabolized by CYP2C8; SNPs have been investigated in this context before but conclusions are still lacking. We present a prospective study of paclitaxel clearance (CL) in 93 Caucasian females with epithelial ovarian cancer with regard...... to the CYP2C8 *1b, *1c, *3 and *4 genotypes. Material and methods All patients were diagnosed with primary ovarian/peritoneal cancer and received 175mg/m2 paclitaxel over 3 hrs plus carboplatin (AUC5-6) q3w. All patients gave written and verbal consent. The study was approved by ethics committees in Denmark...

  2. Distribution of human CYP2C8*2 allele in three different African populations

    Directory of Open Access Journals (Sweden)

    Paganotti Giacomo M

    2012-04-01

    Full Text Available Abstract Background The aim of this study was to investigate cytochrome P450 2C8*2 (CYP2C8*2 distribution and allele frequency in three populations from West and East Africa exposed to Plasmodium falciparum malaria. CYP2C8 enzyme is involved in the metabolism of the anti-malarials amodiaquine and chloroquine. The presence of the CYP2C8*2 defective allele has been recently associated to higher rate of chloroquine-resistant malaria parasites. Methods A total of 503 young subjects were genotyped for the single nucleotide polymorphism rs11572103 (A/T. Eighty-eight were from southern Senegal, 262 from eastern Uganda and 153 from southern Madagascar. The PCR-RFLP technique was used to discriminate the wild-type (A from the defective allele (T. Results A CYP2C8*2 (T allele frequency of 0.222 ± 0.044 was detected in Senegal, 0.105 ± 0.019 in Uganda and 0.150 ± 0.029 in Madagascar. Conclusions This study demonstrated that CYP2C8*2 allele is widespread in Africa. This allele occurs at different frequency in West and East Africa, being higher in Senegal than in Uganda and Madagascar. These data indicate that an important fraction of the populations analysed has a decreased enzymatic activity, thus being at higher risk for drug accumulation with two possible consequences: i an exacerbation of drug-associated adverse side effects; ii an increase of drug-resistance selection pressure on P. falciparum parasites.

  3. Optimizing turning for locomotion

    Science.gov (United States)

    Burton, Lisa; Hatton, Ross; Choset, Howie; Hosoi, A. E.

    2012-02-01

    Speed and efficiency are common and often adequate metrics to compare locomoting systems. These metrics, however, fail to account for a system's ability to turn, a key component in a system's ability to move a confined environment and an important factor in optimal motion planning. To explore turning strokes for a locomoting system, we develop a kinematic model to relate a system's shape configuration to its external velocity. We exploit this model to visualize the dynamics of the system and determine optimal strokes for multiple systems, including low Reynolds number swimmers and biological systems dominated by inertia. Understanding how shape configurations are related to external velocities enables a better understanding of biological and man made systems. Using these tools, we can justify biological system motion and determine optimal shape configurations for robots to maneuver through difficult environments.

  4. Diamond turning of glass

    Energy Technology Data Exchange (ETDEWEB)

    Blackley, W.S.; Scattergood, R.O.

    1988-12-01

    A new research initiative will be undertaken to investigate the critical cutting depth concepts for single point diamond turning of brittle, amorphous materials. Inorganic glasses and a brittle, thermoset polymer (organic glass) are the principal candidate materials. Interrupted cutting tests similar to those done in earlier research are Ge and Si crystals will be made to obtain critical depth values as a function of machining parameters. The results will provide systematic data with which to assess machining performance on glasses and amorphous materials

  5. Hungary's U-Turn

    OpenAIRE

    Kornai, János

    2015-01-01

    For two decades Hungary, like the other Eastern European countries, followed a general policy of establishing and strengthening the institutions of democracy, rule of law, and a market economy based on private property. However, since the elections of 2010, when Viktor Orbán's Fidesz party came to power, Hungary has made a dramatic U-turn. This article investigates the different spheres of society: political institutions, the rule of law, and the influence of state and market on one another, ...

  6. Impact of CYP2C8*3 on paclitaxel clearance

    DEFF Research Database (Denmark)

    Bergmann, T K; Brasch-Andersen, C; Gréen, H

    2011-01-01

    The primary purpose of this study was to evaluate the effect of CYP2C8*3 and three genetic ABCB1 variants on the elimination of paclitaxel. We studied 93 Caucasian women with ovarian cancer treated with paclitaxel and carboplatin. Using sparse sampling and nonlinear mixed effects modeling...

  7. Data of evolutionary structure change: 15C8H-32C2B [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available ain>H 15C8H FNIKD-TYMHW ...> GGG- EEEEture> ATOM 1815 CA PHE H 27 28.7...tryIDChain>32C2B YSISSDYAWNW ucture> EEture...pdbChain> 32C2B GYISY-SGSTS >EEEE - EEE...ce>AQIDPANGNTK >EEEE EEE> ATOM 2

  8. Palladium-Catalyzed Regioselective C8-H Amination of 1-Naphthylamine Derivatives with Aliphatic Amines.

    Science.gov (United States)

    Li, Zexian; Sun, Suyan; Qiao, Huijie; Yang, Fan; Zhu, Yu; Kang, Jianxun; Wu, Yusheng; Wu, Yangjie

    2016-09-16

    A simple and facile protocol for palladium-catalyzed picolinamide-directed C8-H amination of 1-naphthylamine derivatives with simple secondary aliphatic amines was developed, thereby providing a new route to 1,8-naphthalenediamine derivatives. It is noteworthy that the picolinamide moiety as a bidentate directing group may play a key role in this regioselective transformation.

  9. NEHRP turns 40

    Science.gov (United States)

    Leith, William S.

    2017-01-01

    This year, the National Earthquake Hazards Reduction Program (NEHRP) turns 40, four decades since the Earthquake Hazards Reduction Act of 1977 was enacted establishing the Program, spurring numerous federal, state, and community actions to reduce earthquake losses in the U.S.A. and its territories and setting a standard for earthquake loss‐reduction projects internationally. Four agencies are partners in NEHRP: the Federal Emergency Management Agency (FEMA), the National Institute of Standards and Technology (NIST, the lead agency), the National Science Foundation (NSF), and the U.S. Geological Survey (USGS).

  10. The Affective Turn

    Directory of Open Access Journals (Sweden)

    Alí Lara

    2013-11-01

    Full Text Available In the last decade studies on affect and emotions have become relevant in the social sciences. This is not just a fad guideline, but instead a simultaneous reader of public life changes and subjective experience, from which it is also being transformed the knowledge production. Such a trend has been known as ‘The Affective Turn’ within the Anglophone Academy. Here we will translate it as ‘El Giro Afectivo’. This turn, so far, has not dabbled in the social science literature that is written in Spanish. This paper draws on a singular panorama of discussions about contemporary social studies of affect and emotion, and it’s vertebrate by some of its expressions in the contemporary academy.

  11. Fermilab turns 50! Congratulations!

    CERN Multimedia

    Staff Association

    2017-01-01

    This year Fermilab turns 50 and the celebrations are ongoing. The ties between CERN and Fermilab are numerous and have been ranging from competition between two labs at the forefront of their field, e.g. with the chase of the top quark, finally discovered by Fermilab, to outright collaboration, e.g. on LHC low-beta quadrupole magnet development and production and in the CMS collaboration. In June, in the name of the CERN staff and scientific community, the CERN Staff Association sent a message to the Fermilab staff and scientific community, through Dr. Nigel Lockyer, Fermilab Director. The letter, and the assurance from Nigel Lockyer that the message has been passed onto the Fermilab community can be found on our website. Congratulations to Fermilab on its fiftieth Anniversary, and to the staff and collaborators who made this laboratory through their hard work, dedication and vision!

  12. A Quasar Turns On

    Science.gov (United States)

    Kohler, Susanna

    2017-02-01

    The intermediate Palomar Transient Factory (iPTF) has discovered a quasar the brightly-shining, active nucleus of a galaxy abruptly turning on in what appears to be the fastest such transition ever seen in such an object.A Rapid TransitionQuasars are expected to show variations in brightness on timescales of hours to millions of years, but its not often that we get to study their major variability in real time! So far, weve discovered only a dozen changing-look quasars active galactic nuclei that exhibit major changes in their spectral class and brightness between observations. Roughly half of these were quasars that turned on and half were quasars that turned off, generally on timescales of maybe 5 or 10 years.The dramatic change in spectrum of iPTF 16bco between the archival SDSS data from 2004 (bottom) and the follow-up spectroscopy from Keck 2+DEIMOS in 2016 (top). [Adapted from Gezari et al. 2017]In June 2016, however, a team of scientists led by Suvi Gezari (University of Maryland) discovered iPTF 16bco, a nuclear transient that wasnt there the last time Palomar checked in 2012. A search through archival Sloan Digital Sky Survey and GALEX data in addition to some follow-up X-ray imaging and spectroscopic observations told the team what they needed to know: iPTF 16bco is a quasar that only just turned on within the 500 days preceding the iPTF observations.This source, in fact, is a 100-million-solar-mass black hole located at the center of a galaxy at a redshift of z= 0.237. In just over a year, the source changed classification from a galaxy with weak narrow-line emission to a quasar with characteristic strong, broad emission lines and a ten-fold increase in continuum brightness! What caused this sudden transition?Instabilities at Fault?iPTF 16bco and the other known changing-look quasars with disappearing (red circles) and appearing (blue circles) broad-line emission. [Adapted from Gezari et al. 2017]Gezari and collaborators used the large number of recent

  13. Lattice Calibration with Turn-By-Turn BPM Data

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Xiaobiao; /SLAC; Sebek, James; /SLAC

    2012-07-02

    Turn-by-turn beam position monitor (BPM) data from multiple BPMs are fitted with a tracking code to calibrate magnet strengths in a manner similar to the well known LOCO code. Simulation shows that this turn-by-turn method can be a quick and efficient way for optics calibration. The method is applicable to both linacs and ring accelerators. Experimental results for a section of the SPEAR3 ring is also shown.

  14. Turn by Turn Measurements at the KEK-ATF

    CERN Document Server

    Renier, Y; Tomas, R; Wendt, M; Eddy, N; Kubo, K; Kuroda, S; Naito, T; Okugi, T; Terunuma, N; Urakawa, J

    2013-01-01

    The ATF damping ring has been upgraded with new read-out electronics for the beam position monitors (BPM), capable to acquire the beam orbits on a turn-by-turn basis, as well as in a high resolution averaging mode. The new BPM system allows to improve optic corrections and to achieve an even smaller vertical emittance (<2pm). Experimental results are presented based on turn-by-turn beam orbit measurements in the ring, for estimating the β functions and dispersion along the lattice. A fast method to measure spectral line amplitude in a few turns is also presented, including the evaluation of chromaticity.

  15. Synthesis and glycosidase inhibitory activity of new hexa-substituted C8-glycomimetics

    Directory of Open Access Journals (Sweden)

    Prangé Thierry

    2005-10-01

    Full Text Available Text abstract Background Glycosidases are involved in several metabolic pathways and the development of inhibitors is an important challenge towards the treatment of diseases, such as diabetes, cancer and viral infections including AIDS. Thus, inhibition of intestinal α-glucosidases can be used to treat diabetes through the lowering of blood glucose levels, and α-glucosidase inhibitors are being marketed against type 2 (non-insulinodependent mellitus diabetes (i.e.: Glyset® or Diastabol®, Basen® and Glucor® or Precose®. Results In that context, new C8-carbasugars and related aminocyclitols have been targeted in order to study the effect of the enhanced flexibility and of the new spatial distribution displayed by these structures on their adaptability in the active site of the enzymes. The synthesis of these new C8-glycomimetics is described from enantiomerically pure C2-symmetrical polyhydroxylated cyclooctenes. Their obtention notably involved a syn-dihydroxylation, and more extended functionalization through formation of a cis-cyclic sulfate followed by amination and subsequent reductive amination. This strategy involving the nucleophilic opening of a cis-cyclic sulfate by sodium azide is to our knowledge the first example in C8-series. It revealead to be an efficient alternative to the nucleoplilic opening of an epoxide moiety which proved unsuccessful in this particular case, due to the hindered conformation of such epoxides as demonstrated by X-ray cristallographic analysis. Conclusion The biological activity of the synthesized glycomimetics has been evaluated towards 24 commercially available glycosidases. The weak observed activities can probably be related to the spatial disposition of the hydroxy and amino groups which depart too much from that realized in glycomimetics such as valiolamine, voglibose and valienamine. Nevertheless, the synthetic strategy described here is efficient and general, and could be extended to increase

  16. On the role of cytochrome c8 in photosynthetic electron transfer of the purple non-sulfur bacterium Rhodoferax fermentans

    DEFF Research Database (Denmark)

    Hochkoeppler, Alejandro; Ciurli, Stefano; Kofod, Pauli

    1997-01-01

    of +285 mV. Partial analysis of the N-terminus amino-acid sequence shows a high similarity with cytochromes of c8 type (formerly called Pseudomonas cytochrome c-551 type). Time-resolved spectrophotometric studies show that this cytochrome c8 reduces the tetraheme subunit of the photosynthetic reaction...... center, in a fast (sub-ms) and a slow (ms) phase. Competition experiments in the presence of both cytochrome c8 and high potential iron-sulfur protein (HiPIP), isolated from the same microorganism, show that cytochrome c8 oxidation is decreased upon addition of HiPIP. These observations suggest...

  17. Nerve transfer for sensory reconstruction of C8-T1 dermatomes in tetraplegia.

    Science.gov (United States)

    Bertelli, Jayme A; Ghizoni, Marcos F

    2016-11-01

    Absence of sensation in C8-T1 dermatome is a common finding in midcervical spinal cord injury. The goal was to restore sensation on the C8-T1 dermatomes by transferring sensory nerves with afferents on C5-C6 roots. A mean 10 months post spinal cord injury, we operated on 10 upper limbs from 5 tetraplegics averaging 23 years old. Cutaneous branches of the median nerve were transferred to the palm to the ulnar proper digital nerve of the little finger. In two patients, the lateral antebrachial cutaneous nerve was also transferred to the medial antebrachial cutaneous nerve. At a mean 20 months after surgery, on the ulnar side of the hand and little finger, all patients were able to perceive 19.3 g Semmes-Weinstein monofilament pressure. Nociception was restored on the medial side of the elbow, forearm, and hand. Faulty location was a common finding, but not as a major complaint. Sensory nerve transfers should be incorporated into the reconstruction of the upper limb in tetraplegics. © 2015 Wiley Periodicals, Inc. Microsurgery 36:637-641, 2016. © 2016 Wiley Periodicals, Inc.

  18. Clinical characteristics of rod and cone photoreceptor dystrophies in patients with mutations in the C8orf37 gene

    NARCIS (Netherlands)

    Huet, R.A.C. van; Estrada-Cuzcano, A.; Banin, E.; Rotenstreich, Y.; Hipp, S.; Kohl, S.; Hoyng, C.B.; Hollander, A.I. den; Collin, R.W.J.; Klevering, B.J.

    2013-01-01

    PURPOSE: To provide the clinical features in patients with retinal disease caused by C8orf37 gene mutations. METHODS: Eight patients--four diagnosed with retinitis pigmentosa (RP) and four with cone-rod dystrophy (CRD), carrying causal C8orf37 mutations--were clinically evaluated, including

  19. Preliminary safety assessment of C-8 xylitol monoester and xylitol phosphate esters.

    Science.gov (United States)

    Silveira, J E P S; Pereda, M C V; Nogueira, C; Dieamant, G; Cesar, C K M; Assanome, K M; Silva, M S; Torello, C O; Queiroz, M L S; Eberlin, S

    2016-02-01

    Most of the cosmetic compounds with preservative properties available in the market pose some risks concerning safety, such as the possibility of causing sensitization. Due to the fact that there are few options, the proper development of new molecules with this purpose is needed. Xylitol is a natural sugar, and the antimicrobial properties of xylitol-derived compounds have already been described in the literature. C-8 xylitol monoester and xylitol phosphate esters may be useful for the development of skincare products. As an initial screen for safety of chemicals, the combination of in silico methods and in vitro testing can aid in prioritizing resources in toxicological investigations while reducing the ethical and monetary costs that are related to animal and human testing. This study was designed to evaluate the safety of C-8 xylitol monoester and xylitol phosphate esters regarding carcinogenicity, mutagenicity, skin and eye irritation/corrosion and sensitization through alternative methods. For the initial safety assessment, quantitative structure-activity relationship methodology was used. The prediction of the parameters carcinogenicity/mutagenicity, skin and eye irritation/corrosion and sensitization was generated from the chemical structure. The analysis also comprised physical-chemical properties, Cramer rules, threshold of toxicological concern and Michael reaction. In silico results of candidate molecules were compared to 19 compounds with preservative properties that are available in the market. Additionally, in vitro tests (Ames test for mutagenicity, cytotoxicity and phototoxicity tests and hen's egg test--chorioallantoic membrane for irritation) were performed to complement the evaluation. In silico evaluation of both molecules presented no structural alerts related to eye and skin irritation, corrosion and sensitization, but some alerts for micronucleus and carcinogenicity were detected. However, by comparison, C-8 xylitol monoester, xylitol

  20. Synthesis of the C8’-epimeric thymine pyranosyl amino acid core of amipurimycin

    Directory of Open Access Journals (Sweden)

    Pramod R. Markad

    2016-08-01

    Full Text Available The C8’-epimeric pyranosyl amino acid core 2 of amipurimycin was synthesized from D-glucose derived alcohol 3 in 13 steps and 14% overall yield. Thus, the Sharpless asymmetric epoxidation of allyl alcohol 7 followed by trimethyl borate mediated regio-selective oxirane ring opening with azide, afforded azido diol 10. The acid-catalyzed 1,2-acetonide ring opening in 10 concomitantly led to the formation of the pyranose ring skeleton to give 2,7-dioxabicyclo[3.2.1]octane 12. Functional group manipulation in 12 gave 21 that on stereoselective β-glycosylation afforded the pyranosyl thymine nucleoside 2 – a core of amipurimycin.

  1. Sequence-selective binding of C8-conjugated pyrrolobenzodiazepines (PBDs) to DNA.

    Science.gov (United States)

    Basher, Mohammad A; Rahman, Khondaker Miraz; Jackson, Paul J M; Thurston, David E; Fox, Keith R

    2017-11-01

    DNA footprinting and melting experiments have been used to examine the sequence-specific binding of C8-conjugates of pyrrolobenzodiazepines (PBDs) and benzofused rings including benzothiophene and benzofuran, which are attached using pyrrole- or imidazole-containing linkers. The conjugates modulate the covalent attachment points of the PBDs, so that they bind best to guanines flanked by A/T-rich sequences on either the 5'- or 3'-side. The linker affects the binding, and pyrrole produces larger changes than imidazole. Melting studies with 14-mer oligonucleotide duplexes confirm covalent attachment of the conjugates, which show a different selectivity to anthramycin and reveal that more than one ligand molecule can bind to each duplex. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Toward the Total Synthesis of Amphidinolide O: An Enantioselective Synthesis of C3-C8 Fragment

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Minho; Lee, Duckhyung [Sogang Univ., Seoul (Korea, Republic of)

    2013-07-15

    The methyl ester 4, a C3-C8 fragment of am-phidinolide O (1), was prepared enantioselectively via 11 steps in 14% overall yields. The diastereoselective Ireland-Claisen rearrangement of 5 via the corresponding (E)-enolate intermediate was used as a key step in order to implement the C4 and C5 chiral centers. Retrosynthetic analysis was described in Figure 1. Amphi-dinolide O (1) might be assembled from two intermediates 2 and 3 via esterification and ring closing metathesis as key steps. Intermediate 4, a precursor to 3 as well as the target molecule in this paper, involves the γ,δ-unsaturated ester moiety along with α,β-chiral substituents with anti-stereochemical relationship.

  3. Directional solidification of C8-BTBT films induced by temperature gradients and its application for transistors

    Science.gov (United States)

    Fujieda, Ichiro; Iizuka, Naoki; Onishi, Yosuke

    2015-03-01

    Because charge transport in a single crystal is anisotropic in nature, directional growth of single crystals would enhance device performance and reduce its variation among devices. For an organic thin film, a method based on a temperature gradient would offer advantages in throughput and cleanliness. In experiments, a temperature gradient was established in a spin-coated film of 2,7-dioctyl [1]benzothieno[3,2-b]benzothiophene (C8-BTBT) by two methods. First, a sample was placed on a metal plate bridging two heat stages. When one of the heat stages was cooled, the material started to solidify from the colder region. The melt-solid interface proceeded along the temperature gradient. Cracks were formed perpendicular to the solidification direction. Second, a line-shaped region on the film was continuously exposed to the light from a halogen lamp. After the heat stage was cooled, cracks similar to the first experiment were observed, indicating that the melt-solid interface moved laterally. We fabricated top-contact, bottom-gate transistors with these films. Despite the cracks, field-effect mobility of the transistors fabricated with these films was close to 6 cm2 /Vs and 4 cm2 /Vs in the first and second experiment, respectively. Elimination of cracks would improve charge transport and reduce performance variation among devices. It should be noted that the intense light from the halogen lamp did not damage the C8-BTBT films. The vast knowledge on laser annealing is now available for directional growth of this type of materials. The associated cost would be much smaller because an organic thin film melts at a low temperature.

  4. Secretome of the Coprophilous Fungus Doratomyces stemonitis C8, Isolated from Koala Feces.

    Science.gov (United States)

    Peterson, Robyn; Grinyer, Jasmine; Nevalainen, Helena

    2011-06-01

    Coprophilous fungi inhabit herbivore feces, secreting enzymes to degrade the most recalcitrant parts of plant biomass that have resisted the digestive process. Consequently, the secretomes of coprophilous fungi have high potential to contain novel and efficient plant cell wall degrading enzymes of biotechnological interest. We have used one-dimensional and two-dimensional gel electrophoresis, matrix-assisted laser desorption ionization-time-of-flight tandem mass spectrometry (MALDI-TOF/TOF MS/MS), and quadrupole time-of-flight liquid chromatography-tandem mass spectrometry (Q-TOF LC-MS/MS) to identify proteins from the secretome of the coprophilous fungus Doratomyces stemonitis C8 (EU551185) isolated from koala feces. As the genome of D. stemonitis has not been sequenced, cross-species identification, de novo sequencing, and zymography formed an integral part of the analysis. A broad range of enzymes involved in the degradation of cellulose, hemicellulose, pectin, lignin, and protein were revealed, dominated by cellobiohydrolase of the glycosyl hydrolase family 7 and endo-1,4-β-xylanase of the glycosyl hydrolase family 10. A high degree of specialization for pectin degradation in the D. stemonitis C8 secretome distinguishes it from the secretomes of some other saprophytic fungi, such as the industrially exploited T. reesei. In the first proteomic analysis of the secretome of a coprophilous fungus reported to date, the identified enzymes provide valuable insight into how coprophilous fungi subsist on herbivore feces, and these findings hold potential for increasing the efficiency of plant biomass degradation in industrial processes such as biofuel production in the future.

  5. Sandstone Turning by Abrasive Waterjet

    Czech Academy of Sciences Publication Activity Database

    Hlaváček, Petr; Cárach, J.; Hloch, Sergej; Vasilko, K.; Klichová, Dagmar; Klich, Jiří; Lehocká, D.

    2015-01-01

    Roč. 48, č. 6 (2015), s. 2489-2493 ISSN 0723-2632 R&D Projects: GA MŠk ED2.1.00/03.0082; GA MŠk(CZ) LO1406 Institutional support: RVO:68145535 Keywords : turning away from the jet * conventional turning towards the jet * sandstone * abrasive water jet Subject RIV: JQ - Machines ; Tools Impact factor: 2.386, year: 2015 http://www.springerprofessional.de/sandstone-turning-by-abrasive-waterjet/6038028.html

  6. A Turning Point for Literacy

    Science.gov (United States)

    Literacy Work, 1977

    1977-01-01

    Discusses the publication "A Turning Point for Literacy" edited by Leon Bataille, and based on information from the International Symposium for Literacy (1975). The author notes that the document represents the complete history and background of literacy from the point of departure in 1965 to a turning point in 1975. (TA)

  7. Turns and maneuvers during swimming

    Science.gov (United States)

    Bhalla, Amneet; Mosberg, Noah; Bale, Rahul; Patankar, Neelesh

    2011-11-01

    In this work we use fully resolved fluid dynamics computations based on an immersed body approach to study fish turns and maneuvers. We present a numerical method to control the trajectory of fish during turns and maneuvers. Fish tracking a prey is presented as an example case. Numerical simulations are carried out on spatially adaptive grid for speed and accuracy. The effect of deformation kinematics and Reynolds number (Re), on the turn radius of an undulatory swimmer, is studied. Power spent during turning at different turn radii and Re is also reported. These results can be used to quantify the cost of various maneuvers and to identify efficient maneuvers to attain the same objective, e.g., reaching a target location during prey tracking. NSF support is gratefully acknowledged.

  8. Effect of C8mimPF6 on miniemulsion polymerization for application in new latex coating products.

    Science.gov (United States)

    Hu, Binjie; Kong, Yiyang; Zheng, Rongmeihui; Dong, Jie; Choy, Kwang-Leong; Zhao, Huanhuan

    2016-08-15

    C8mimPF6, as a type of room temperature ionic liquid (RTIL) with non-volatility and a low melting point, may replace conventional coalescing agents in latex coatings, thus preventing volatile organic compound (VOC) emissions caused by coalescing agents. In this study, systematic investigations on the effect of various factors including initiator type, initiator concentration, temperature and C8mimPF6 concentration on the conversion of latex and droplet/particle size of a miniemulsion during polymerization have been conducted. The presence of C8mimPF6 has shown to have a marked effect on the reaction rate. Such an effect strongly depends on the type of initiator being used. For polymerization initiated by 2,2-azobis (isobutyronitrile) (AIBN), C8mimPF6 had a promoting effect on the reaction rate at low concentrations, but this effect might be reversed upon certain C8mimPF6 concentrations, e.g. 10 wt%. While initiated by H2O2/Vc, this promoting effect faded even at low C8mimPF6 concentrations. The different limiting factors, which determine the reaction rate with different types of initiator, may contribute to the results. For reactions initiated by hydrophobic AIBN, the reaction was dominated by kinetics. The presence of C8mimPF6 may cause an enhanced chain propagation rate and reduced chain termination rate, which may further contribute to the increase in reaction rate at lower concentrations of C8mimPF6. With hydrophilic H2O2/Vc, the resistance for the transfer of radicals into a droplet/particle might be increased significantly with increasing C8mimPF6 concentration due to a tighter interfacial structure at lower concentrations of C8mimPF6. Thus, such transfer of radicals may become a limiting step whilst the presence of C8mimPF6 increases the transfer resistance on radicals resulting in a decrease in reaction rate. The reaction temperature, which is related to the decomposition temperature of the initiator being used, was another factor affecting the conversion

  9. The role of the C8 proton of ATP in the regulation of phosphoryl transfer within kinases and synthetases

    CSIR Research Space (South Africa)

    Kenyon, CP

    2011-07-01

    Full Text Available and KIE. Effect of the concentration of ATP and C8D-ATP on the specific activity (A) and KIE (B) of Saccharomyces cerevisiae hexokinase. (A) ?black circle ? = ATP, black square? = C8D-ATP, (B) Black = KIE, Blue = KIED. The specific enzyme activity... of the residues in facilitating binding and cat- alysis associated with the C8H-ATP. Methods Enzyme source and protein expression and purification Hexokinase from Saccharomyces cerevisiae Type F-300 (Sigma, H4502), Fructose Phosphokinase (Sigma, F0137...

  10. TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS.

    Science.gov (United States)

    Noy, Peter J; Yang, Jing; Reyat, Jasmeet S; Matthews, Alexandra L; Charlton, Alice E; Furmston, Joanna; Rogers, David A; Rainger, G Ed; Tomlinson, Michael G

    2016-02-12

    A disintegrin and metalloprotease 10 (ADAM10) is a ubiquitously expressed transmembrane metalloprotease that cleaves the extracellular regions from its transmembrane substrates. ADAM10 is essential for embryonic development and is implicated in cancer, Alzheimer, and inflammatory diseases. The tetraspanins are a superfamily of 33 four-transmembrane proteins in mammals, of which the TspanC8 subgroup (Tspan5, 10, 14, 15, 17, and 33) promote ADAM10 intracellular trafficking and enzymatic maturation. However, the interaction between TspanC8s and ADAM10 has only been demonstrated in overexpression systems and the interaction mechanism remains undefined. To address these issues, an antibody was developed to Tspan14, which was used to show co-immunoprecipitation of Tspan14 with ADAM10 in primary human cells. Chimeric Tspan14 constructs demonstrated that the large extracellular loop of Tspan14 mediated its co-immunoprecipitation with ADAM10, and promoted ADAM10 maturation and trafficking to the cell surface. Chimeric ADAM10 constructs showed that membrane-proximal stalk, cysteine-rich, and disintegrin domains of ADAM10 mediated its co-immunoprecipitation with Tspan14 and other TspanC8s. This TspanC8-interacting region was required for ADAM10 exit from the endoplasmic reticulum. Truncated ADAM10 constructs revealed differential TspanC8 binding requirements for the stalk, cysteine-rich, and disintegrin domains. Moreover, Tspan15 was the only TspanC8 to promote cleavage of the ADAM10 substrate N-cadherin, whereas Tspan14 was unique in reducing cleavage of the platelet collagen receptor GPVI. These findings suggest that ADAM10 may adopt distinct conformations in complex with different TspanC8s, which could impact on substrate selectivity. Furthermore, this study identifies regions of TspanC8s and ADAM10 for potential interaction-disrupting therapeutic targeting. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  11. Lipophilicity of porphyrins and their retention in IAM, C8-C18 and HILIC chromatographic systems.

    Science.gov (United States)

    Essaid, D; Chaminade, P; Maillard, Ph; Kasselouri, A

    2015-10-10

    Porphyrins are a class of photosensitizers used in photodynamic therapy (PDT). Understanding the interaction of porphyrins with membrane cells components is important in order to improve this therapy. Many analytical methods can be used for this aim. High performance liquid chromatography (HPLC) was used for the separation of porphyrins on RP and HILIC stationary phases as well as on a biomimetic membrane IAM phase. Twenty-six tetraphenyl porphyrins (TPP) were successfully separated on an IAM column, a C18 Gravity RP column, a C8 Gravity RP column, a PolarTec RP column and a HILIC column. Stationary phases were chosen as the most appropriate to cover the study of different types of interactions. Elution was performed with a 45 min linear gradient. Obtained gradient retention times were converted to gradient chromatography hydrophobicity index (CHI) and to an apparent retention factor (kapp). The partition coefficients (logP) of the 26 compounds were measured in a 2-octanol/PBS system and estimated in silico. Correlation between kapp values was studied. Moreover, a multivariate analysis was performed to explain columns relationships. Obtained results show that porphyrins are separated mainly according to hydrophobic interactions that are relative to their structure (sugar number and the disposition around the porphyrin macrocycle). Copyright © 2015 Elsevier B.V. All rights reserved.

  12. Perfluorocarbons and Gilbert syndrome (phenotype) in the C8 Health Study Population

    Energy Technology Data Exchange (ETDEWEB)

    Fan, Hongmin [Cancer Center, School of Public Health, West Virginia University, Morgantown, WV 265050-9190 (United States); Department of Epidemiology and Statistics, School of Public Health, Hebei United University, Hebei 063000 (China); Ducatman, Alan [Department of Occupational and Environmental Health, School of Public Health, West Virginia University (United States); Department of Medicine, School of Medicine, West Virginia University (United States); Clinical Translational Science Institute, West Virginia University (United States); Zhang, Jianjun [Department of Biostatistics, School Public Health, West Virginia University (United States)

    2014-11-15

    Background: Gilbert syndrome (GS) is an inherited defect of bilirubin conjugation, most commonly caused by a gene mutation for the enzyme UGT1A. GS is known to affect the metabolism and excretion of drugs and xenobiotics. Perfluorocarbon compounds (PFCs) are bio-persistent environmental contaminants that affect metabolic regulation. In this study, we examined the associations of GS phenotype and serum PFCs in the C8 Health Study Population. Materials and methods: Using 2005–2006 data from a large PFC-exposure population survey, we compared serum PFCs concentrations between GS and non GS clinical phenotypes, in a cross sectional design, adjusting for standard risk factors, including age, BMI, smoking status, socioeconomic status and gender. Results: Among 10 PFC compounds considered, only perfluorohexanoic acid (PFHxA) was seen at a significantly higher concentration in GS men and women. Conclusion: PFHxA exposure may be associated with GS. Our findings do not support increased exposure in GS for other PFCs. - Highlights: • Most serum PFCs are not associated with clinically evident Gilbert syndrome. • However, serum perfluorohexanoic acid is positively associated. • The investigation addresses the clinical presentation, not the genetic mutation.

  13. Optical and Morphological Studies of Thermally Evaporated PTCDI-C8 Thin Films for Organic Solar Cell Applications

    Directory of Open Access Journals (Sweden)

    Ronak Rahimi

    2013-01-01

    Full Text Available PTCDI-C8 due to its relatively high photosensitivity and high electron mobility has attracted much attention in organic semiconductor devices. In this work, thin films of PTCDI-C8 with different thicknesses were deposited on silicon substrates with native silicon dioxide using a vacuum thermal evaporator. Several material characterization techniques have been utilized to evaluate the structure, morphology, and optical properties of these films. Their optical constants (refractive index and extinction coefficient have been extracted from the spectroscopic ellipsometry (SE. X-ray reflectivity (XRR and atomic force microscopy (AFM were employed to determine the morphology and structure as well as the thickness and roughness of the PTCDI-C8 thin films. These films revealed a high degree of structural ordering within the layers. All the experimental measurements were performed under ambient conditions. PTCDI-C8 films have shown to endure ambient condition which allows pots-deposition characterization.

  14. Turning collectors for solar radiation

    Science.gov (United States)

    Barak, Amitzur Z.

    1976-01-01

    A device is provided for turning a solar collector about the polar axis so that the collector is directed toward the sun as the sun tracks the sky each day. It includes two heat-expansive elements and a shadow plate. In the morning a first expansive element is heated, expands to turn the collector to face the sun, while the second expansive element is shaded by the plate. In the afternoon the second element is heated, expands to turn the collector to face the sun, while the first is shaded by the plate.

  15. Novel C8-linked pyrrolobenzodiazepine (PBD)-heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box.

    Science.gov (United States)

    Brucoli, Federico; Hawkins, Rachel M; James, Colin H; Wells, Geoff; Jenkins, Terence C; Ellis, Tom; Hartley, John A; Howard, Philip W; Thurston, David E

    2011-06-15

    A series of novel DNA-interactive C8-linked pyrrolobenzodiazepine (PBD)-heterocycle polyamide conjugates has been synthesised to explore structure/sequence-selectivity relationships. One conjugate (2d) has a greater selectivity and DNA binding affinity for inverted CCAAT sequences within the Topoisomerase IIα promoter than the known C8-bis-pyrrole PBD conjugate GWL-78 (1b). Copyright © 2011 Elsevier Ltd. All rights reserved.

  16. Turning around Newton's Second Law

    Science.gov (United States)

    Goff, John Eric

    2004-01-01

    Conceptual and quantitative difficulties surrounding Newton's second law often arise among introductory physics students. Simply turning around how one expresses Newton's second law may assist students in their understanding of a deceptively simple-looking equation.

  17. What 'empirical turn in bioethics'?

    Science.gov (United States)

    Hurst, Samia

    2010-10-01

    Uncertainty as to how we should articulate empirical data and normative reasoning seems to underlie most difficulties regarding the 'empirical turn' in bioethics. This article examines three different ways in which we could understand 'empirical turn'. Using real facts in normative reasoning is trivial and would not represent a 'turn'. Becoming an empirical discipline through a shift to the social and neurosciences would be a turn away from normative thinking, which we should not take. Conducting empirical research to inform normative reasoning is the usual meaning given to the term 'empirical turn'. In this sense, however, the turn is incomplete. Bioethics has imported methodological tools from empirical disciplines, but too often it has not imported the standards to which researchers in these disciplines are held. Integrating empirical and normative approaches also represents true added difficulties. Addressing these issues from the standpoint of debates on the fact-value distinction can cloud very real methodological concerns by displacing the debate to a level of abstraction where they need not be apparent. Ideally, empirical research in bioethics should meet standards for empirical and normative validity similar to those used in the source disciplines for these methods, and articulate these aspects clearly and appropriately. More modestly, criteria to ensure that none of these standards are completely left aside would improve the quality of empirical bioethics research and partly clear the air of critiques addressing its theoretical justification, when its rigour in the particularly difficult context of interdisciplinarity is what should be at stake.

  18. The role of the C8 proton of ATP in the regulation of phosphoryl transfer within kinases and synthetases

    Directory of Open Access Journals (Sweden)

    Nkosi Thokozani C

    2011-07-01

    Full Text Available Abstract Background The kinome comprises functionally diverse enzymes, with the current classification indicating very little about the extent of conserved regulatory mechanisms associated with phosphoryl transfer. The apparent Km of the kinases ranges from less than 0.4 μM to in excess of 1000 μM for ATP. It is not known how this diverse range of enzymes mechanistically achieves the regulation of catalysis via an affinity range for ATP varying by three-orders of magnitude. Results We have demonstrated a previously undiscovered mechanism in kinase and synthetase enzymes where the overall rate of reaction is regulated via the C8-H of ATP. Using ATP deuterated at the C8 position (C8D-ATP as a molecular probe it was shown that the C8-H plays a direct role in the regulation of the overall rate of reaction in a range of kinase and synthetase enzymes. Using comparative studies on the effect of the concentration of ATP and C8D-ATP on the activity of the enzymes we demonstrated that not only did C8D-ATP give a kinetic isotope effect (KIE but the KIE's obtained are clearly not secondary KIE effects as the magnitude of the KIE in all cases was at least 2 fold and in most cases in excess of 7 fold. Conclusions Kinase and synthetase enzymes utilise C8D-ATP in preference to non-deuterated ATP. The KIE obtained at low ATP concentrations is clearly a primary KIE demonstrating strong evidence that the bond to the isotopically substituted hydrogen is being broken. The effect of the ATP concentration profile on the KIE was used to develop a model whereby the C8H of ATP plays a role in the overall regulation of phosphoryl transfer. This role of the C8H of ATP in the regulation of substrate binding appears to have been conserved in all kinase and synthetase enzymes as one of the mechanisms associated with binding of ATP. The induction of the C8H to be labile by active site residues coordinated to the ATP purine ring may play a significant role in explaining the

  19. The effects of human CYP2C8 genotype and fluvoxamine on the pharmacokinetics of rosiglitazone in healthy subjects

    DEFF Research Database (Denmark)

    Pedersen, Rasmus S; Damkier, Per; Brosen, Kim

    2006-01-01

    AIMS: To determine the effect of CYP2C8 genotype and of fluvoxamine on the pharmacokinetics of rosiglitazone. METHODS: Twenty-three healthy subjects with the following genotypes were included in a two-phase, open-label, cross-over trial: CYP2C8*3/ *3 (n = 3), CYP2C8*1/ *3 (n = 10) and CYP2C8*1/ *1...... (n = 10). In Phase A, the subjects were given 4 mg rosiglitazone as a single oral dose. In Phase B, the subjects were treated with multiple oral doses of 50 mg fluvoxamine maleate for 3 days prior to the single oral administration of 4 mg rosiglitazone. Plasma concentrations of rosiglitazone...... and relative amounts of N-desmethylrosiglitazone were measured in both phases for 24 h after drug administration. RESULTS: The pharmacokinetics of rosiglitazone and N-desmethylrosiglitazone were not significantly different between the CYP2C8 genotypic groups. Fluvoxamine caused a statistically significant (P...

  20. A novel C8orf37 splice mutation and genotype-phenotype correlation for cone-rod dystrophy.

    Science.gov (United States)

    Rahner, Nils; Nuernberg, Gudrun; Finis, David; Nuernberg, Peter; Royer-Pokora, Brigitte

    2016-09-01

    To identify the disease-causing mutation in a consanguineous family of Morrocan origin with syndromic autosomal recessive (ar) cone-rod dystrophy (CRD) in two patients and describe genotype-phenotype correlations. Genome-wide homozygosity mapping and direct sequencing of C8orf37, located in a homozygous interval, was performed in the family. mRNA analysis revealed the effect of the newly identified splice-site mutation. For a comparative analysis phenotypic and genetic data of C8orf37 mutations were extracted from published cases. The new splice-site mutation c.155+2T>C identified in the family results in a skipping of 82 bp. The CRD phenotypes of our patients were consistent with previous reports. Non-ocular findings in our patients and two previously described patients were postaxial polydactyly present at birth. Both families with additional postaxial polydactyly had splice site mutations affecting intron 1 of C8orf37, one at the slice donor and one at the splice acceptor site. This report extends the genotypic spectrum of C8orf37-associated retinal dystrophies and demonstrates for the first time a genotype-phenotype correlation between an arCRD-polydactyly-association and truncating germline mutations affecting the N-terminal region of the protein. Furthermore, our findings underline the ciliary function of C8orf37 protein.

  1. Synthesis, properties, and NMR studies of a C8-phenylguanine modified oligonucleotide that preferentially adopts the Z DNA conformation.

    Science.gov (United States)

    Gannett, Peter M; Heavner, Sue; Daft, Jonathan R; Shaughnessy, Kevin H; Epperson, Jon D; Greenbaum, Nancy L

    2003-10-01

    Carcinogenic aryl hydrazines produce C8-arylated purine adducts. The effect of these adducts on DNA conformation and their role in hydrazine carcinogenesis are unknown. Here, we describe a new synthetic route to produce these adducts that is also compatible with the synthesis of the corresponding phosphoramidites needed for oligonucleotide synthesis. Two oligonucleotides were prepared, an unmodified oligonucleotide, d((5)(')CGCGCGCGCG(3)(')), and a C8-phenylguanine modified oligonucleotide, d((5)(')CGCGCGCGCG(3)(')) (G = 8-phenylguanine). These oligonucleotides were compared using thermal denaturation, circular dichroism, NMR, and molecular modeling. The phenyl modification destabilizes the B DNA form and stabilizes the Z DNA form such that the B:Z ratio is near one under physiological conditions. In light of recent studies that show a role for Z DNA in gene expression and cell transformation, Z DNA stabilization by C8-arylguanine formation from aryl hydrazines may be relevant to their role in carcinogenesis.

  2. The Physics of Ski Turns

    Science.gov (United States)

    Shonle, John I.; Nordick, Douglas L.

    1972-01-01

    Describes the application of basic dynamics of rotations to the case of turning on skis, first without and then with external torques. Various elements are combined in different techniques and suggestions for further extensions and a list of laboratory exercises based on skiing are included. (DF)

  3. The Philosophy of Turning Points

    DEFF Research Database (Denmark)

    Turcan, Romeo V.

    2013-01-01

    This paper introduces and discusses the concept of turning points from the ontological, epistemological, and methodological perspectives, applying it to the de-internationalization phenomenon to exemplify its deployment. As a concept that adds to the variance and complexity of the international b...... of a generalizable international business and management theory....

  4. Professional Employees Turn to Unions

    Science.gov (United States)

    Chamot, Dennis

    1976-01-01

    White-collar and professional employees are increasingly turning to unions to combat their loss of independence as employees of large organizations. Managers should realize that they and professional employees have different viewpoints about job situations and that the current trend toward white-collar unionism is apt to continue. (JG)

  5. Hamilton's theory of turns revisited

    Indian Academy of Sciences (India)

    Hamilton's theory of turns, arising out of his profound and more general theory of quaternions, gives a beautiful geometric visualization of the elements of the groups. SO(3) and SU(2), and of their noncommutative composition laws [1]. Thus, group elements can be pictured as equivalence classes of directed great circle arcs ...

  6. Hamilton's theory of turns revisited

    Indian Academy of Sciences (India)

    We present a new approach to Hamilton's theory of turns for the groups (3) and (2) which renders their properties, in particular their composition law, nearly trivial and immediately evident upon inspection. We show that the entire construction can be based on binary rotations rather than mirror reflections.

  7. Turn Management or Impression Management?

    NARCIS (Netherlands)

    ter Maat, Mark; Heylen, Dirk K.J.; Ruttkay, Z.M.; Kipp, M.; Nijholt, Antinus; Vilhjálmsson, H.H.

    2009-01-01

    We look at how some basic choices in the management of turns influence the impression that people get from an agent. We look at scales concerning personality, emotion and interpersonal stance. We do this by a person perception study, or rather an agent perception study, using simulated conversations

  8. Human blood and plasma partition coefficients for C4-C8 n-alkanes, isoalkanes, and 1-alkenes.

    Science.gov (United States)

    Mochalski, Paweł; King, Julian; Kupferthaler, Alexander; Unterkofler, Karl; Hinterhuber, Hartmann; Amann, Anton

    2012-06-01

    Human blood:air and plasma:air partition coefficients for C(4)-C(8) n-alkanes, isoalkanes, and 1-alkenes were determined using multiple headspace extraction coupled with solid phase microextraction and gas chromatography. Mean blood:air partition coefficients expressed in the form of dimensionless blood-to-air concentration ratio (g/mL(b)/g/mL(a)) were 0.183, 0.416, 1.08, 2.71, and 5.77 for C(4)-C(8) n-alkanes; 0.079, 0.184, 0.473, 1.3, and 3.18 for C(4)-C(8) isoalkanes; and 0.304, 0.589, 1.32, 3.5, and 7.01 for C(4)-C(8) 1-alkenes, respectively (n = 8). The reported partition coefficient values increased exponentially with boiling points, molecular weights, and the carbon atoms in the particle. The solubility of 1-alkenes in blood was higher than in plasma, whereas the blood:air and plasma:air partition coefficients of n-alkanes and isoalkanes did not differ significantly. Consequently, additional interactions of 1-alkenes with whole blood seem to occur. The presented findings are expected to be particularly useful for assessing the uptake, distribution, and elimination of hydrocarbons in human organism.

  9. CYP2C8 but not CYP3A4 is important in the pharmacokinetics of montelukast

    Science.gov (United States)

    Karonen, Tiina; Neuvonen, Pertti J; Backman, Janne T

    2012-01-01

    AIM According to product information, montelukast is extensively metabolized by CYP3A4 and CYP2C9. However, CYP2C8 was also recently found to be involved. Our aim was to study the effects of selective CYP2C8 and CYP3A4 inhibitors on the pharmacokinetics of montelukast. METHODS In a randomized crossover study, 11 healthy subjects ingested gemfibrozil 600 mg, itraconazole 100 mg (first dose 200 mg) or both, or placebo twice daily for 5 days, and on day 3, 10 mg montelukast. Plasma concentrations of montelukast, gemfibrozil, itraconazole and their metabolites were measured up to 72 h. RESULTS The CYP2C8 inhibitor gemfibrozil increased the AUC(0,∞) of montelukast 4.3-fold and its t1/2 2.1-fold (P montelukast primary metabolite M6, reduced the AUC and Cmax of the secondary (major) metabolite M4 by more than 90% (P montelukast or its M6 and M4 metabolites, but markedly reduced the AUC and Cmax of M5a and M5b (P montelukast did not differ from those of gemfibrozil alone. CONCLUSIONS CYP2C8 is the dominant enzyme in the biotransformation of montelukast in humans, accounting for about 80% of its metabolism. CYP3A4 only mediates the formation of the minor metabolite M5a/b, and is not important in the elimination of montelukast. Montelukast may serve as a safe and useful CYP2C8 probe drug. PMID:21838784

  10. Diamond turning machine controller implementation

    Energy Technology Data Exchange (ETDEWEB)

    Garrard, K.P.; Taylor, L.W.; Knight, B.F.; Fornaro, R.J.

    1988-12-01

    The standard controller for a Pnuemo ASG 2500 Diamond Turning Machine, an Allen Bradley 8200, has been replaced with a custom high-performance design. This controller consists of four major components. Axis position feedback information is provided by a Zygo Axiom 2/20 laser interferometer with 0.1 micro-inch resolution. Hardware interface logic couples the computers digital and analog I/O channels to the diamond turning machine`s analog motor controllers, the laser interferometer, and other machine status and control information. It also provides front panel switches for operator override of the computer controller and implement the emergency stop sequence. The remaining two components, the control computer hardware and software, are discussed in detail below.

  11. Opposed turns at signalized intersections

    Energy Technology Data Exchange (ETDEWEB)

    Akcelik, R.

    1989-06-01

    The 1985 Highway Capacity Manual (HCM) brought the U.S. and Australian methodologies for signalized intersections closer together. An important element in this methodology is the techniques used for the estimation of opposed (permissive) turn saturation flows. Although the basic modeling philosophies of the HCM and Australian methods are similar, there are significant differences in the procedures used and therefore in the results from the two methods. In particular, the latest methodology employed in the SIDRA software has eliminated the use of opposed turn adjustment factors for lane groups and adopted an explicit and direct method of modeling individual lanes. The purpose of this paper is to bring these new methods to the attention of the U.S. researchers since it is understood that efforts are being made to improve the 1985 HCM method.

  12. Diamond turning of thermoplastic polymers

    Energy Technology Data Exchange (ETDEWEB)

    Smith, E.; Scattergood, R.O.

    1988-12-01

    Single point diamond turning studies were made using a series of thermoplastic polymers with different glass transition temperatures. Variations in surface morphology and surface roughness were observed as a function of cutting speed. Lower glass transition temperatures facilitate smoother surface cuts and better surface finish. This can be attributed to the frictional heating that occurs during machining. Because of the very low glass transition temperatures in polymeric compared to inorganic glasses, the precision machining response can be very speed sensitive.

  13. Right turn on red (RTOR)

    OpenAIRE

    Vovk, Žiga

    2013-01-01

    The subject of this thesis is introducing the principle of law permitting right turn on red (in further RTOR) and seeking procedures for better level of service in traffic intersections. In the first part, the work talks about history and usage of the RTOR around the world. Afterwards it focuses on research data from and about traffic accidents, benefits and disadvantages, and dangerous situations occurred because of the RTOR. Thesis concludes with principles of RTOR adjusted for Slovenia inc...

  14. The affective turn in ethnomusicology

    Directory of Open Access Journals (Sweden)

    Hofman Ana

    2015-01-01

    Full Text Available The affective turn, which has already questioned dominant paradigms in many disciplinary fields including cultural studies, philosophy, political theory, anthropology, psychology and neuroscience, has started to attract more attention in the field of ethnomusicology, becoming a particularly vibrant stream of thought. Drawing on the voices that call for the historicisation of and critical deliberation on the field of affect studies, the article strives to show how theories of affect might expand dominant paradigms in ethnomusicology and also points to their limitations.

  15. [Cu(C8H16N4O2)0.5[N(CN)2

    Science.gov (United States)

    Zhang, Bing; Kou, Hui-Zhong; He, Yi; Wang, Hong-Gen; Cui, Ai-Li

    2004-07-01

    A new polymeric copper complex, viz. catena-poly[[[mu-N,N'-bis(3-aminopropyl)oxamidato-kappa6N,N',O:N",N"',O']dicopper(II)]-di-mu-dicyanamido-1:1'kappa2N1:N5;2:2'kappa2N1:N5], [Cu2(C8H16N4O2)(C2N3)2]n or [Cu(oxpn)0.5[N(CN)2

  16. Similarity and Scaling of Turbulent Flame Speeds for Expanding Premixed Flames of C4-C8 n -alkanes

    Science.gov (United States)

    Wu, Fujia; Saha, Abhishek; Chaudhuri, Swetaprovo; Yang, Sheng; Law, Chung K.

    2013-11-01

    We experimentally investigated the propagation speed of constant-pressure expanding flames in near isotropic turbulence using a dual-chamber, fan-stirred vessel. The motivation is to test whether the fuel similarity concept among C4-C8 n-alkanes on laminar flames also holds for turbulent flames. Previously it was found that the laminar flame speed and Markstein length are almost identical for C4-C8 n-alkanes. If this fuel similarity concept can also be shown for turbulent flames, it will suggest a canonical flame structure for large hydrocarbon fuels, i . e . , large fuels always decompose to small C0-C4 fuel fragments before being oxidized, and would significantly simplify the description of the flames. Preliminary results show that in the flamelet and thin-reaction zone, turbulent flame speeds of C4-C8 n-alkanes are indeed largely similar at various conditions, thereby suggesting the fuel similarity for turbulent flames. In addition, it is found that the normalized turbulent flame speed also approximately scales with the square root of an appropriately-defined Reynolds number recently found for C0-C4 fuels. This work was supported by the AFOSR under the technical monitoring of Dr. Chiping Li.

  17. Preliminary Study of High Resolution HPLC Analytical Method for Sedimentary Pigments Based on Coupled C8 Columns

    Science.gov (United States)

    Yao, P.; Yu, Z.; Deng, C.; Liu, S.; Zhao, J.

    2008-05-01

    The pigments in marine water columns can provide accurate estimates of community composition and abundance of phytoplankton. In addition, the sedimentary pigments, especially the derivatives of chlorophyll such as pyrophaeophytins, pyrophaeophorbides and steryl chlorin esters (SCEs) formed during early diagenesis can also provide information on the primary producer community and the changes in paleoproductivity. Accordingly, analysis of pigments and their derivatives is of great importance for oceanography, limnology and geochemistry. Many methods have been developed for the separation of chlorophylls, carotenoids and their derivatives derived from phytoplankton and water column samples using high-performance liquid chromatography (HPLC). Methods widely cited in the literatures include those developed by Wright et al. (1991) and Zapata et al. (2000). Both methods use reversed-phase columns, but C18 column was employed in Wright et al. (1991) and C8 column in Zapata et al. (2000). However, evident coelutions are observed in published works. This will particularly cause problematic identification and quantification in dealing with sedimentary pigments which are highly complex and often display a broad range in polarity. Clearly, it is necessary to improve the separation of the complex pigments if the information carried by the pigments is to be used fully. Coupled C18 columns were used in the HPLC method developed by Airs et al. (2001) for the analysis of complex pigment distributions. Improved chromatographic resolution, more pigment components and novel bacteriochlorophyll derivatives were obtained by this method. It indicates a new road for HPLC method development. C8 column has shorter carbon chains than that of C18 column and can provide less retention of apolar compounds which is of particular advantaged to hydrophobic chlorophyll a, b and their derivatives. That is one of the reasons why the C8 method developed by Zapata et al. (2000) is admittedly better than

  18. Aromaticity, optical properties and zero field splitting of homo- and hetero-bimetallic (C8H8)M(μ2-,η8═C8H8)M(C8H8) where M = Ti, Zr, Th Complexes.

    Science.gov (United States)

    Páez-Hernández, Dayán; Arratia-Pérez, Ramiro

    2012-07-19

    This work presents a relativistic calculation of electron delocalization, optical properties, and zero field splitting in a group of molecules with the structure (C(8)H(8))M(μ(2)-,η(8)═C(8)H(8))M(C(8)H(8)), where M = Ti, Zr and Th. Additionally we also studied the heterobimetallic combinations (Ti-Th and Zr-Th). The molecular properties are discussed based on their electronic structure and the influence of the electron mobility in metal-metal communication. Nucleus independent chemical shift (NICS) was determined via the gauge-including-atomic-orbital (GIAO) method with the OPBE functional. The time-dependent density functional theory (TDDFT) was employed to calculate excitation energies, and the electronic transitions over 500 nm are presented with the objective to analyze the transition metal role as an antenna effect in the absorption band in the near-IR region. Finally the ZFS was calculated using Pederson-Khana and coupled perturbed DFT approaches implemented in the ORCA code. The contributions to spin-spin coupling (SS) and spin-orbit coupling (SOC) were analyzed, and the spin-density over the metal centers is discussed employing our scheme of metal-metal communication. Our aim is to determine the influence of the electronic structure over the optical and magnetic properties in a group of model compounds to understand the transition metals effect over these properties.

  19. Turning CSR on it's head

    DEFF Research Database (Denmark)

    Kampf, Constance Elizabeth

    their ecological footprint. Then CarrotMob members use social media to recruit as many customers as possible to shop at that time, thus increasing both profits and available resources for the business to engage in sustainability. As sustainability and CSR are enacted differently in the US and EU (Matten and Moon....... However, from a technology perspective, Howe (2009) argues that the boundaries of the firm are becoming porous, and through social media people are contributing some of their best energy for free. These technology empowered stakeholders can be resources for strategy when the firm is seen as having porous......, rather than impermeable boundaries. Thus, social and mobile media can be approached as a force that works at further eroding boundaries between the firm and technology empowered individuals equipped with their personal agendas and social media capital. As an example of social media turning tradition...

  20. Visualisation turns down energy demand

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Ole Michael [Danish Building and Urban Research, Hoersholm (Denmark)

    2003-07-01

    After many energy saving campaigns, Danish families give the impression that they are conscious of energy consumption. Children have learned to turn off the light and adults to buy low-energy bulbs and household appliances. Questioned about their energy consumption and its fluctuations, the same people nevertheless confess to not really knowing. You pay your energy bill but pay no attention to the current consumption, or its level. Unlike other types of consumption, energy consumption is an almost invisible type of consumption. Nevertheless, as a secondary consumption it is much affected by primary consumption in the form of white goods, appliances, cars, food etc., the main purpose of which usually is visibility. This paper presents the result of an experiment to make the energy consumption visible. Meters in the flats showing actual electricity, heat and water consumption confront tenants with the consequences of their own behaviour. The experiment also investigates different set-ups concerning information and communication about energy consumption. Monthly consumption and levels of consumption compared within the neighbourhood are elements of this information. Also quarterly eco-accounting, with key-figures of consumption and environmental considerations like CO{sub 2} emission, are part of the information set-up. Within the first year of visualisation one case shows a 9% reduction of heat and a 22% reduction of electricity. The other cases seem to follow the same tendency. The philosophy of the experiment is that you must know your position in order to change it. You must know about the level of your own energy consumption in order to turn down energy demand. The visible meters are elements in 'Urban Ecological Renewal of a Housing Block' (Hedebygade Block) in a central district of Copenhagen.

  1. Next speakers plan their turn early and speak after turn-final "go-signals"

    NARCIS (Netherlands)

    Barthel, M.; Meyer, A.S.; Levinson, S.C.

    2017-01-01

    In conversation, turn-taking is usually fluid, with next speakers taking their turn right after the end of the previous turn. One reason for this fluency is early content planning of the next turn, if possible while the current turn is still coming in, as found by Barthel et al. (2016) using the

  2. William Friedman, Geneticist Turned Cryptographer.

    Science.gov (United States)

    Goldman, Irwin L

    2017-05-01

    William Friedman (1891-1969), trained as a plant geneticist at Cornell University, was employed at Riverbank Laboratories by the eccentric millionaire George Fabyan to work on wheat breeding. Friedman, however, soon became intrigued by and started working on a pet project of Fabyan's involving the conjecture that Francis Bacon, a polymath known for the study of ciphers, was the real author of Shakespeare's plays. Thus, beginning in ∼1916, Friedman turned his attention to the so called "Baconian cipher," and developed decryption techniques that bore similarity to approaches for solving problems in population genetics. His most significant, indeed pathbreaking, work used ideas from genetics and statistics, focusing on analysis of the frequencies of letters in language use. Although he had transitioned from being a geneticist to a cryptographer, his earlier work had resonance in his later pursuits. He soon began working directly for the United States government and produced solutions used to solve complex military ciphers, in particular to break the Japanese Purple code during World War II. Another important legacy of his work was the establishment of the Signal Intelligence Service and eventually the National Security Agency. Copyright © 2017 by the Genetics Society of America.

  3. Notes on the Spatial Turn

    Directory of Open Access Journals (Sweden)

    Stipe Grgas

    2012-06-01

    Full Text Available On the basis of ever-mounting evidence, amongst which is the “zone” problematic of the Zadar conference that occassioned these notes, it can be concluded that the spatial turn has insinuated itself as an all-pervading heuristic tool throughout the humanities and the social sciences. The extent to which space and spatiality have usurped the central stage in the various branches of reasearch can be gauged by admonishments that what we are witnessing is a new fundamentalism that has simply inverted the terms of the dualism of time and space (May and Thrift 2001: “Introduction”. According to Michael Dear the sway of space is manifested in multifold ways: in the ubiquity of spatial analysis in social theories and practices; in the explosion of publications devoted to the exploration of the interface of the social and the spatial; in the reintegration of human geography into various domains of knowledge; in the focus given to difference and the consequent diversification of theoretical and empirical practices; in a theoretically informed exploration of the relation between geographical knowledge and social action; and, finally, in the unprecedented proliferation of research agendas and publications pertaining to these isuuses (Dear 2001: 24. Two recent collections of papers are indicative of the ubiquity of spatial issues in scholarly work.

  4. Efficient control of the rheological and surface properties of surfactant solutions containing C8-C18 fatty acids as cosurfactants.

    Science.gov (United States)

    Mitrinova, Z; Tcholakova, S; Popova, Z; Denkov, N; Dasgupta, Bivash R; Ananthapadmanabhan, K P

    2013-07-02

    Systematic experimental study is performed about the effects of chain length (varied between C8 and C18) and concentration of fatty acids (FAc), used as cosurfactants to the mixture of the anionic surfactant SLES and the zwitterionic surfactant CAPB. The following properties are studied: bulk viscosity of the concentrated solutions (10 wt % surfactants), dynamic and equilibrium surface tensions, surface modulus, and foam rheological properties for the diluted foaming solutions (0.5 wt % surfactants). The obtained results show that C8-C10 FAc induce formation of wormlike micelles in the concentrated surfactant solutions, which leads to transformation of these solutions into viscoelastic fluids with very high apparent viscosity. The same FAc shorten the characteristic adsorption time of the diluted solutions by more than 10 times. In contrast, C14-C18 FAc have small effect on the viscosity of the concentrated solutions but increase the surface modulus above 350 mN/m, which leads to higher friction inside sheared foams and to much smaller bubbles in the formed foams. The intermediate chain C12 FAc combines some of the properties seen with C10 FAc and other properties seen with C14 FAc. These results clearly demonstrate how appropriate cosurfactants can be used for efficient control of the rheological properties of concentrated surfactant solutions and of some important foam attributes, such as bubble size and foam rheology.

  5. 32 CFR 636.23 - Turning movements.

    Science.gov (United States)

    2010-07-01

    ... Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL... movements. (a) U-turns are prohibited on all streets in the cantonment area. (b) Right-turns will be made from a position as close to the right edge or right curb of the roadway as possible. (c) Left-turns...

  6. Competitive CH Activation in (Pentamethylcyclopentadienyl)(cyclooctatetraene)alkylzirconium Compounds Cp*Zr(COT)R. Selective Formation of Fulvene or Cyclooctatrienyne Ligands. Molecular Structure of Cp*Zr(μ-η8 : η2-C8H6)ZrCp*(η4-C8H8), a Dinuclear Zwitt

    NARCIS (Netherlands)

    Sinnema, Piet-Jan; Meetsma, Auke; Teuben, Jan H.

    1993-01-01

    Thermolysis of Cp*Zr(COT)R (Cp* = η5-C5Me5, COT = η8-C8H8, R = CH2SiMe3, Me) proceeds via a double hydrogen abstraction from a cyclooctatetraene ligand to give RH and Cp*Zr(μ-η8:η2-C8H6)ZrCp*(η4-C8H8) as the kinetic product. Cp*Zr(μ-η8:η2-C8H6)ZrCp*(η4-C8H8) undergoes a thermally induced hydrogen

  7. Interfacial chemical and electronic structure of cobalt deposition on 2,7-dioctyl[1]benzothieno[3,2-b]benzothiophene (C8-BTBT)

    Science.gov (United States)

    Zhu, Menglong; Lyu, Lu; Niu, Dongmei; Zhang, Hong; Zhang, Yuhe; Liu, Peng; Gao, Yongli

    2017-04-01

    Interfacial chemical and electronic structure of Co deposition on 2,7-dioctyl[1]benzothieno[3,2-b]benzothiophene(C8-BTBT) was investigated by ultraviolet photoemission spectroscopy (UPS) and X-ray photoemission spectroscopy (XPS). Chemical reaction of cobalt with C8-BTBT at the interface is confirmed by a new component of S 2s peak which is electron-rich compared to the original one of C8-BTBT molecules. Intensity evolution of the core level in XPS indicates that the adsorption of Co atoms is mainly at the surface without deeper diffusion into C8-BTBT layer. Initial deposition of Co atoms downward shifts the core levels of C8-BTBT by electron transfer from isolated Co atoms or clusters to the C8-BTBT. Further deposition of Co upward shifts the core levels of C8-BTBT because of the neutralization of the thicker metal Co film. Our investigation suggests an inert buffer layer inserted to protect organic layer from reaction or decomposition and to lower the carrier barriers for both the electron and hole to improve the performance of Co/C8-BTBT-based OFETs.

  8. Interfacial chemical and electronic structure of cobalt deposition on 2,7-dioctyl[1]benzothieno[3,2-b]benzothiophene (C8-BTBT)

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Menglong; Lyu, Lu [Institute of Super-Microstructure and Ultrafast Process in Advanced Materials, School of Physics and Electronics, Central South University, Changsha, Hunan 410083 (China); Hunan Key Laboratory for Super-Microstructure and Ultrafast Process, School of Physics and Electronics, Central South University, Changsha, Hunan 410083 (China); Niu, Dongmei, E-mail: mayee@csu.edu.cn [Institute of Super-Microstructure and Ultrafast Process in Advanced Materials, School of Physics and Electronics, Central South University, Changsha, Hunan 410083 (China); Hunan Key Laboratory for Super-Microstructure and Ultrafast Process, School of Physics and Electronics, Central South University, Changsha, Hunan 410083 (China); Zhang, Hong; Zhang, Yuhe; Liu, Peng [Institute of Super-Microstructure and Ultrafast Process in Advanced Materials, School of Physics and Electronics, Central South University, Changsha, Hunan 410083 (China); Hunan Key Laboratory for Super-Microstructure and Ultrafast Process, School of Physics and Electronics, Central South University, Changsha, Hunan 410083 (China); Gao, Yongli, E-mail: ygao@pas.rochester.edu [Institute of Super-Microstructure and Ultrafast Process in Advanced Materials, School of Physics and Electronics, Central South University, Changsha, Hunan 410083 (China); Hunan Key Laboratory for Super-Microstructure and Ultrafast Process, School of Physics and Electronics, Central South University, Changsha, Hunan 410083 (China); Department of Physics and Astronomy, University of Rochester, Rochester NY14627 (United States)

    2017-04-30

    Highlights: • Chemical reaction and band bending at the interface are confirmed by the UPS and XPS. • Co atoms mostly accumulate at or near the interface and penetration into sublayer is weak. • The electron and hole barriers are too high and interfacial buffer layer is needed for device design. - Abstract: Interfacial chemical and electronic structure of Co deposition on 2,7-dioctyl[1]benzothieno[3,2-b]benzothiophene(C8-BTBT) was investigated by ultraviolet photoemission spectroscopy (UPS) and X-ray photoemission spectroscopy (XPS). Chemical reaction of cobalt with C8-BTBT at the interface is confirmed by a new component of S 2s peak which is electron-rich compared to the original one of C8-BTBT molecules. Intensity evolution of the core level in XPS indicates that the adsorption of Co atoms is mainly at the surface without deeper diffusion into C8-BTBT layer. Initial deposition of Co atoms downward shifts the core levels of C8-BTBT by electron transfer from isolated Co atoms or clusters to the C8-BTBT. Further deposition of Co upward shifts the core levels of C8-BTBT because of the neutralization of the thicker metal Co film. Our investigation suggests an inert buffer layer inserted to protect organic layer from reaction or decomposition and to lower the carrier barriers for both the electron and hole to improve the performance of Co/C8-BTBT-based OFETs.

  9. Conformational Preference and Fluorescence Response of a C-Linked C8-Biphenyl-Guanine Lesion in the NarI Mutational Hotspot: Evidence for Enhanced Syn Adduct Formation.

    Science.gov (United States)

    Berger, Florence D; Sturla, Shana J; Kung, Ryan W; Montina, Tony; Wetmore, Stacey D; Manderville, Richard A

    2018-01-16

    Aromatic chemical carcinogens can undergo enzymatic transformations to produce a range of electrophilic species that attach covalently to the C8-site of 2'-deoxyguanosine (dG) to afford C8-dG adducts. The most studied C8-dG adducts are formed from arylamines and contain a N-linkage separating the dG from the C8-aryl moiety. Other carcinogenic species result in direct aryl ring attachment to the dG moiety, resulting in C-linked adducts. The resulting C-linked adducts have reduced conformational flexibility compared to the corresponding N-linked C8-dG adducts, which can alter their orientation in the DNA duplex. Described herein are structural studies of a fluorescent C-linked 4-fluorobiphenyl-dG (FBP-dG) that has been incorporated into the reiterated G3-postion of the 12-mer NarI sequence and those containing other 5'-flanking nucleobases. FBP-dG displays a strong preference for adopting a syn conformation in the fully paired NarI duplex to produce an intercalated structure that exhibits stacking interactions between the C-linked biphenyl and the flanking bases. FBP-dG is also shown to significantly stabilize the slippage mutagenic intermediate (SMI) duplex containing the lesion and 5'-flanking base within a 2-base bulge. FBP-dG exhibits fluorescence sensitivity to SMI duplex formation that can readily distinguish it from the fully paired duplex. Molecular dynamics simulations and optical spectroscopy for the NarI oligonucleotides containing the C-linked FBP-dG predict increased rigidity of the biphenyl in the syn conformation. The greater propensity to generate the promutagenic syn conformation for the C-linked FBP-dG adduct compared to the N-linked 4-aminobiphenyl-dG adduct (ABP-dG) suggests greater mutagenicity for the C-linked analogue. These results highlight the effect of the adduct linkage type on the conformational properties of adducted DNA. The turn-on emission response of FBP-dG in the SMI duplex may be a powerful tool for monitoring SMI formation in the

  10. Quantitative analysis of reinforcing phase in AlSi11/CrFe30C8 composite castings

    Directory of Open Access Journals (Sweden)

    A. Dulęba

    2011-07-01

    Full Text Available In this paper assessment of the morphology and segregation of the reinforcing phase based on optical quantitative analysis was achieved. Microscopic observation of AlSi11/CrFe30C8 composite gravity castings was carried out in electromagnetic field. The purpose of investigation was the analysis of current frequency influence supplying the inductor of electromagnetic field on segregation, quantity and morphology of reinforcement phase in aluminum matrix composite. Technological conception of investigations was based on assumption that chromium-iron matrix of particles dissolved in aluminum composite matrix and carbide phases became actual reinforcement of the composite. Gravity segregation was analyzed. Graphs containing distribution of reinforcing phase in metal matrix were shown.

  11. Analysis of the Functional Polymorphism in the Cytochrome P450 CYP2C8 Gene rs11572080 with Regard to Colorectal Cancer Risk

    Science.gov (United States)

    Ladero, José M.; Agúndez, José A. G.; Martínez, Carmen; Amo, Gemma; Ayuso, Pedro; García-Martín, Elena

    2012-01-01

    In addition to the known effects on drug metabolism and response, functional polymorphisms of genes coding for xenobiotic-metabolizing enzymes (XME) play a role in cancer. Genes coding for XME act as low-penetrance genes and confer modest but consistent and significant risks for a variety of cancers related to the interaction of environmental and genetic factors. Consistent evidence supports a role for polymorphisms of the cytochrome P450 CYP2C9 gene as a protecting factor for colorectal cancer susceptibility. It has been shown that CYP2C8 and CYP2C9 overlap in substrate specificity. Because CYP2C8 has the common functional polymorphisms rs11572080 and rs10509681 (CYP2C8*3), it could be speculated that part of the findings attributed to CYP2C9 polymorphisms may actually be related to the presence of polymorphisms in the CYP2C8 gene. Nevertheless, little attention has been paid to the role of the CYP2C8 polymorphism in colorectal cancer. We analyzed the influence of the CYP2C8*3 allele in the risk of developing colorectal cancer in genomic DNA from 153 individuals suffering colorectal cancer and from 298 age- and gender-matched control subjects. Our findings do not support any effect of the CYP2C8*3 allele (OR for carriers of functional CYP2C8 alleles = 0.50 (95% CI = 0.16–1.59; p = 0.233). The absence of a relative risk related to CYP2C8*3 did not vary depending on the tumor site. We conclude that the risk of developing colorectal cancer does not seem to be related to the commonest functional genetic variation in the CYP2C8 gene. PMID:23420707

  12. Do vehicular emissions dominate the source of C6-C8 aromatics in the megacity Shanghai of eastern China?

    Science.gov (United States)

    Wang, Hongli; Wang, Qian; Chen, Jianmin; Chen, Changhong; Huang, Cheng; Qiao, Liping; Lou, Shengrong; Lu, Jun

    2015-01-01

    The characteristic ratios of volatile organic compounds (VOCs) to i-pentane, the indicator of vehicular emissions, were employed to apportion the vehicular and non-vehicular contributions to reactive species in urban Shanghai. Two kinds of tunnel experiments, one tunnel with more than 90% light duty gasoline vehicles and the other with more than 60% light duty diesel vehicles, were carried out to study the characteristic ratios of vehicle-related emissions from December 2009 to January 2010. Based on the experiments, the characteristic ratios of C6-C8 aromatics to i-pentane of vehicular emissions were 0.53 ± 0.08 (benzene), 0.70 ± 0.12 (toluene), 0.41 ± 0.09 (m,p-xylenes), 0.16 ± 0.04 (o-xylene), 0.023 ± 0.011 (styrene), and 0.15 ± 0.02 (ethylbenzene), respectively. The source apportionment results showed that around 23.3% of C6-C8 aromatics in urban Shanghai were from vehicular emissions, which meant that the non-vehicular emissions had more importance. These findings suggested that emission control of non-vehicular sources, i.e. industrial emissions, should also receive attention in addition to the control of vehicle-related emissions in Shanghai. The chemical removal of VOCs during the transport from emissions to the receptor site had a large impact on the apportionment results. Generally, the overestimation of vehicular contributions would occur when the VOC reaction rate constant with OH radicals (kOH) was larger than that of the vehicular indicator, while for species with smaller kOH than the vehicular indicator, the vehicular contribution would be underestimated by the method of characteristic ratios. Copyright © 2014. Published by Elsevier B.V.

  13. Impact of Exposure Uncertainty on the Association between Perfluorooctanoate and Preeclampsia in the C8 Health Project Population.

    Science.gov (United States)

    Avanasi, Raghavendhran; Shin, Hyeong-Moo; Vieira, Verónica M; Savitz, David A; Bartell, Scott M

    2016-01-01

    Uncertainty in exposure estimates from models can result in exposure measurement error and can potentially affect the validity of epidemiological studies. We recently used a suite of environmental models and an integrated exposure and pharmacokinetic model to estimate individual perfluorooctanoate (PFOA) serum concentrations and assess the association with preeclampsia from 1990 through 2006 for the C8 Health Project participants. The aims of the current study are to evaluate impact of uncertainty in estimated PFOA drinking-water concentrations on estimated serum concentrations and their reported epidemiological association with preeclampsia. For each individual public water district, we used Monte Carlo simulations to vary the year-by-year PFOA drinking-water concentration by randomly sampling from lognormal distributions for random error in the yearly public water district PFOA concentrations, systematic error specific to each water district, and global systematic error in the release assessment (using the estimated concentrations from the original fate and transport model as medians and a range of 2-, 5-, and 10-fold uncertainty). Uncertainty in PFOA water concentrations could cause major changes in estimated serum PFOA concentrations among participants. However, there is relatively little impact on the resulting epidemiological association in our simulations. The contribution of exposure uncertainty to the total uncertainty (including regression parameter variance) ranged from 5% to 31%, and bias was negligible. We found that correlated exposure uncertainty can substantially change estimated PFOA serum concentrations, but results in only minor impacts on the epidemiological association between PFOA and preeclampsia. Avanasi R, Shin HM, Vieira VM, Savitz DA, Bartell SM. 2016. Impact of exposure uncertainty on the association between perfluorooctanoate and preeclampsia in the C8 Health Project population. Environ Health Perspect 124:126-132; http://dx.doi.org/10

  14. Realistic page-turning of electronic books

    Science.gov (United States)

    Fan, Chaoran; Li, Haisheng; Bai, Yannan

    2014-01-01

    The booming electronic books (e-books), as an extension to the paper book, are popular with readers. Recently, many efforts are put into the realistic page-turning simulation o f e-book to improve its reading experience. This paper presents a new 3D page-turning simulation approach, which employs piecewise time-dependent cylindrical surfaces to describe the turning page and constructs smooth transition method between time-dependent cylinders. The page-turning animation is produced by sequentially mapping the turning page into the cylinders with different radii and positions. Compared to the previous approaches, our method is able to imitate various effects efficiently and obtains more natural animation of turning page.

  15. Mechanics of the Fouetté turn.

    Science.gov (United States)

    Imura, Akiko; Yeadon, M R

    2010-12-01

    The Fouetté turn in classical ballet is performed repeatedly on one leg with swinging of the free limbs, producing a continued sequence of turns with one turn leading into the next. The purpose of this study was to determine the possible time history profiles of the twisting torque between the supporting leg and the remainder of the body that will allow continued performances of the Fouetté turn. Simulations were performed using a model which comprised the supporting leg and the remainder of the body to find torque profiles that maintain the initial angular velocity so that the state after one revolution is the same as the initial state. The solution space of torque profiles was determined for various rotation times and coefficients of friction between foot and floor. As the time for one revolution became shorter the solution space became smaller and for a given turn time there was a lower limit on the coefficient of friction. As the frictional coefficient became smaller the solution space became smaller and for a given coefficient there was a lower limit on the turn time. Turns of a given tempo can be performed on floors with different friction by modifying the twisting torque profile. When a turn is completed with a net change in angular velocity this can be compensated for in the next turn by adjusting the twisting torque profile. Copyright © 2010 Elsevier B.V. All rights reserved.

  16. Investigation of the in vitro toxicological properties of the synthetic cannabimimetic drug CP-47,497-C8

    Energy Technology Data Exchange (ETDEWEB)

    Koller, Verena J., E-mail: verena.koller@meduniwien.ac.at [Institute of Cancer Research, Department of Internal Medicine 1, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8A, 1090 Vienna (Austria); Auwärter, Volker, E-mail: volker.auwaerter@uniklinik-freiburg.de [Institute of Forensic Medicine, University Medical Center Freiburg, Albertstraße 9, 79104 Freiburg (Germany); Grummt, Tamara, E-mail: tamara.grummt@uba.de [German Federal Environmental Agency, Heinrich-Heine-Str., 12, 08645 Bad Elster (Germany); Moosmann, Bjoern, E-mail: bjoern.moosmann@uniklinik-freiburg.de [Institute of Forensic Medicine, University Medical Center Freiburg, Albertstraße 9, 79104 Freiburg (Germany); Mišík, Miroslav, E-mail: miroslav.misik@meduniwien.ac.at [Institute of Cancer Research, Department of Internal Medicine 1, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8A, 1090 Vienna (Austria); Knasmüller, Siegfried, E-mail: siegfried.knasmueller@meduniwien.ac.at [Institute of Cancer Research, Department of Internal Medicine 1, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8A, 1090 Vienna (Austria)

    2014-06-01

    Cannabicyclohexanol (CP-47,497-C8) is a representative of a group of cannabimimetic cyclohexylphenols which is added to herbal mixtures as a cannabis substitute since 2008. Although in the beginning CP-47,497-C8 was the main ingredient of “Spice” and similar products, it was partly replaced by aminoalkylindole-type cannabinoid receptor agonists like JWH-018, JWH-073 or JWH-250, but never completely disappeared from the market. Since information on its toxicological properties is scarce, we investigated the effects of the drug in human derived cell lines. The cytotoxic effects were studied in a panel of assays (SRB, XTT, LDHe and NR tests) in a buccal derived (TR146) and a liver derived (HepG2) cell line. The strongest effects were seen in the two former assays at levels ≥ 7.5 μM indicating that the compound interferes with protein synthesis and causes membrane damage. In additional comet assays, DNA damage was detected at levels ≥ 10 μM. Experiments with lesion specific enzymes showed that these effects are not due to oxidative damage of DNA bases. The negative findings obtained in Salmonella/microsome assays and the positive results of micronucleus tests with the cell lines indicate that the compound does not cause gene mutations but acts on the chromosomal level. In contrast to other synthetic cannabinoids, no indication for estrogenic/antiestrogenic properties was seen in a luciferase assay with bone marrow derived U2-OS cells. In conclusion, our findings show that the drug has only weak cytotoxic properties. However, the induction of chromosomal damage indicates that it may cause adverse effects in users due to its impact on the stability of the genetic material. - Highlights: • We tested the toxic properties of a synthetic cannabinoid. • Acute cytotoxic effects were detected with doses ≥ 7 μM. • No hormonal effects were found. • DNA damage was detected at levels ≥ 10 μM in comet assay and micronucleus tests. • Effects in directly

  17. Do benzodiazepines mimic reverse-turn structures?

    Science.gov (United States)

    Hata, Masayuki; Marshall, Garland R.

    2006-05-01

    The role of benzodiazepine derivatives (BZD) as a privileged scaffold that mimics β-turn structures (Ripka et al. (1993) Tetrahedron 49:3593-3608) in peptide/protein recognition was reexamined in detail. Stable BZD ring conformers were determined with MM3, and experimental reverse-turn structures were extracted from the basis set of protein crystal structures previously defined by Ripka et al. Ideal β-turns were also modeled and similarly compared with BZD conformers. Huge numbers of conformers were generated by systematically scanning the torsional degrees of freedom for BZDs, as well as those of ideal β-turns for comparison. Using these structures, conformers of BZDs were fit to experimental structures as suggested by Ripka et al., or modeled classical β-turn conformers, and the root-mean-square deviation (RMSD) values were calculated for each pairwise comparison. Pairs of conformers with the smallest RMSD values for overlap of the four α-β side-chain orientations were selected. All overlaps of BZD conformers with experimental β-turns yielded one or more comparisons where the least RMSD was significantly small, 0.48-0.86 Å, as previously suggested. Utilizing a different methodology, the overall conclusion that benzodiazepines could serve as reverse-turn mimetics of Ripka et al. is justified. The least RMSD values for the overlap of BZDs and modeled classical β-turns were also less than 1 Å. When comparing BZDs with experimental or classical β-turns, the set of experimental β-turns selected by Ripka et al. fit the BZD scaffolds better than modeled classical β-turns; however, all the experimental β-turns did not fit a particular BZD scaffold better. A single BZD ring conformation, and/or chiral orientation, can mimic some, but not all, of the experimental β-turn structures. BZD has two central ring conformations and one chiral center that explains why the four variations of the BZD scaffold can mimic all types of β-turn structure examined. It was

  18. Equipment and modifications that enabled infant child-care by a mother with C8 tetraplegia: a case report.

    Science.gov (United States)

    Cowley, Kristine C

    2007-01-01

    In the past, rehabilitative effort after spinal cord injury has focused on maximizing physical functioning related to activities of daily living and self-care, with less emphasis on issues such as care-giving. The number of women becoming pregnant and rearing children after spinal cord injury has increased in recent years, but descriptions of equipment and modifications used in child-care are scarce. Equipment and techniques that enable physical independence in providing infant-care by persons with low-level tetraplegia has not previously been described. This case report describes the modified equipment and physical strategies used by a mother with C8 tetraplegia to physically care for her young infants. Relevant issues of physical function were identified, potential sources for equipment and techniques were reviewed, and then the equipment and technique solutions were formulated. Attachment arms and brackets were made so that a lightweight stroller could be attached directly to the mother's manual wheelchair, a crib was modified with sliding Lexan doors so that it could be accessed at wheelchair level, and a table with sides was designed and built to act as a play surface where the mother could independently place an infant. All other pieces of baby-care equipment were commercially available and the mother developed strategies for their use without modification. With the exception of bathing, using the tools and techniques described, this mother was able to achieve physical independence in providing her children's infant care.

  19. performance characteristics of a cam turning attachment

    African Journals Online (AJOL)

    Dr Obe

    ABSTRACT. A modification of a cylindrical turning unit has been done to give a non- cylindrical turning attachment for production of irregular shapes, like cams on the lathe machine. To assess the performance of the attachment, cutting forces have been measured using a 'Sigma' Cutting Tool. Dynamometer. Furthermore ...

  20. Separation of chlorophylls and carotenoids from marine phytoplankton: a new HPLC method using a reversed phase C8 column and pyridine-containing mobile phases

    National Research Council Canada - National Science Library

    Manuel Zapata; Francisco Rodríguez; José L. Garrido

    2000-01-01

    A high-performance liquid chromatographic (HPLC) method based on a reversed-phase C8 column and pyridine-containing mobile phases was developed for the simultaneous separation of chlorophylls and carotenoids...

  1. Interface electronic structure and morphology of 2,7-dioctyl[1]benzothieno[3,2-b]benzothiophene (C8-BTBT) on Au film

    Science.gov (United States)

    Wang, Shitan; Niu, Dongmei; Lyu, Lu; Huang, Yingbao; Wei, Xuhui; Wang, Can; Xie, Haipeng; Gao, Yongli

    2017-09-01

    The interfacial electronic structure and morphology of 2,7-dioctyl[1]benzothieno[3,2-b]benzothiophene(C8-BTBT) on polycrystalline Au film was investigated with photoemission spectroscopy (PES), atomic force microscopy (AFM) and grazing incidence X-ray diffraction (GIXRD). The transport barriers of holes and electrons at the interface are 1.72 eV and 2.12 eV, respectively, from the UPS measurement. There is no chemical reaction of C8-BTBT with Au from the XPS investigation of core levels Au 4f, C 1s and S 2p. The upmost molecules adopt a standing up configuration deduced from the diffraction peaks in GIXRD and the step height in AFM. Increasing order of the upright orientation of C8-BTBT molecules with film growth result in decreasing work function of the C8-BTBT thin film by forming an outward pointing dipole layer with the ordered end Csbnd H bonds.

  2. Kantian Turning Point in Gadamer's Philosophical Hermeneutics

    Directory of Open Access Journals (Sweden)

    Kristína Bosáková

    2016-11-01

    Full Text Available The paper is treating the theme of a Kantian turning-point in the philosophical hermeneutics of H.- G. Gadamer based on of the harmonic relationship between metaphysics and science in Kantian philosophy from the point of view of the philosophical hermeneutics of Gadamer. The philosophical work of Kant had such an influence on Gadamer that without exaggerating we can talk about the Kantian turning-point in Gadamerian hermeneutics. Grondin, a former student of Gadamer, is talking about Kantian turning-point on the field of aesthetics, but in reality Kantian turning-point means much more than a mere change in the reception of the concept of judgement. It is a discovery of harmonical relationship between the beauty and the moral, between the reason and the sensitivity, between the modern sciences and the metaphysical tradition in the Kantian philosophy, made by Gadamer. This is what we call the Kantian turning-point in Gadamerian hermeneutics.

  3. COMPETITIVE CH ACTIVATION IN (PENTAMETHYLCYCLOPENTADIENYL)(CYCLOOCTATETRAENE)ALKYLZIRCONIUM COMPOUNDS CP-ASTERISK-ZR(COT)R - SELECTIVE FORMATION OF FULVENE OR CYCLOOCTATRIENYNE LIGANDS - MOLECULAR-STRUCTURE OF CP-ASTERISK-ZR(MU-ETA-8-ETA-2-C8H6)ZRCP-ASTERISK(ETA-4-C8H8), A DINUCLEAR ZWITTERIONIC ZIRCONIUM COMPLEX WITH A BRIDGING CYCLOOCTARIENYNE LIGAND

    NARCIS (Netherlands)

    SINNEMA, PJ; MEETSMA, A; TEUBEN, JH

    Thermolysis of Cp*Zr(COT)R (Cp* = eta5-C5Me5, COT = eta8-C8H8, R = CH2SiMe3, Me) proceeds via a double hydrogen abstraction from a cyclooctatetraene ligand to give RH and Cp*Zr(mu-eta8:eta2-C8H6)ZrCp*(eta4-C8H8) as the kinetic product. Cp*Zr(mu-eta8:eta2-C8H6) undergoes a thermally induced hydrogen

  4. Measurement uncertainty assessment of magnesium trisilicate column for determination of Sudan colorants in food by HPLC using C8 column.

    Science.gov (United States)

    Chen, Ying; He, Chao; Cheng, Jing-Jun; Huang, Wen-Yao; Shao, Sheng-Wen; Jiang, Ya-Ping; Dai, Ling-Feng; Liu, Jia-Fa; Song, Yi

    2016-10-01

    This study aimed to conduct measurement uncertainty assessment of a new method for determination of Sudan colorants (Sudan I, II, III and IV) in food by high performance liquid chromatography (HPLC). Samples were extracted with organic solvents (hexane, 20% acetone) and first purified by magnesium trisilicate (2MgO·3SiO2). The Sudan colorants (Sudan I-IV) were also initially separated on C8 by gradient elution using acetonitrile and 0.1% (v/v) formic acid aqueous solution as the mobile phases and detected with diode-array detector (DAD). The uncertainty of mathematical model of Sudan I, II, III and IV is based on EURACHEM guidelines. The sources and components of uncertainty were calculated. The experiment gave a good linear relationship over the concentration from 0.4 to 4.0 μg/mL and spiked recoveries were from 74.0% to 97.5%. The limits of determination (LOD) were 48, 61, 36, 58 μg/kg for the four analytes, respectively. The total uncertainty of Sudan colorants (Sudan I, II, III and IV) was 810±30.8, 790±28.4, 750±27.0, 730±50.0 μg/kg, respectively. The recovery uncertainty was the most significant factor contributing to the total uncertainty. The developed method is simple, rapid, and highly sensitive. It can be used for the determination of trace Sudan dyes in food samples. The sources of uncertainty have been identified and uncertainty components have been simplified and considered.

  5. Understanding the Function of Genes Involved in Inherited Retinal Degeneration-Insights into the Pathogenesis and Function of C8ORF37

    Science.gov (United States)

    Sharif, Ali Sakawa

    Inherited retinal degenerative diseases (IRD) are a group of disorders that lead to progressive deterioration of mainly the photoreceptors. Retinitis pigmentosa (RP) and cone-rod dystrophy (CRD) are two forms of IRDs. RP is the most common form of IRD and is due to rod photoreceptor degeneration followed by cone photoreceptor loss. CRD, on the other hand, is characterized by the loss of cones or the concurrent degeneration of both cones and rods. Both RP and CRD are presently incurable. More than 200 genes have been identified to cause IRDs and the functions of many of these genes remain unclear. Mutations in a novel gene, C8ORF37, were identified to cause recessive, severe, and early-onset RP and CRD. I, therefore, pioneered in characterizing the role of C8ORF37 in the retina. This dissertation is comprised of four chapters that is organized as follows: (1) summary of an ocular disorder (2) a genetic model of a retinal disorder (3) biochemical/proteomic analysis of C8ORF37 (4) potential clinical applications. A summary of ocular disorders is discussed in Chapter 1, with an emphasis on CRD. Chapter 2 focuses on the generation and characterization of C8orf37 mutant mouse models that recapitulate the retinal pathologies observed in human patients. In C8orf37 knockout retinas, the outer segment (OS) was nonuniform, swollen, and wider in width when compared to the controls. Moreover, many OS membrane proteins were reduced in the retina of C8orf37 knockout, including CNGB1 and RDS, proteins essential for OS disc morphogenesis and alignment. Our findings shed new light on the pathogenesis underlying retinal dysfunction and degeneration in C8ORF37-deficient patients. To determine the function of a novel protein, a powerful approach is by identifying its binding partners. In Chapter 3, I discuss GST pull-down using bovine retinal lysates, yeast-two-hybrid, and immunoprecipitation with mouse retinal lysate in order to identify C8ORF37-interacting proteins. Our pull

  6. 14 CFR 23.203 - Turning flight and accelerated turning stalls.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Turning flight and accelerated turning stalls. 23.203 Section 23.203 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... a 30 degree bank. Reduce speed by steadily and progressively tightening the turn with the elevator...

  7. Next Speakers Plan Their Turn Early and Speak after Turn-Final "Go-Signals".

    Science.gov (United States)

    Barthel, Mathias; Meyer, Antje S; Levinson, Stephen C

    2017-01-01

    In conversation, turn-taking is usually fluid, with next speakers taking their turn right after the end of the previous turn. Most, but not all, previous studies show that next speakers start to plan their turn early, if possible already during the incoming turn. The present study makes use of the list-completion paradigm (Barthel et al., 2016), analyzing speech onset latencies and eye-movements of participants in a task-oriented dialogue with a confederate. The measures are used to disentangle the contributions to the timing of turn-taking of early planning of content on the one hand and initiation of articulation as a reaction to the upcoming turn-end on the other hand. Participants named objects visible on their computer screen in response to utterances that did, or did not, contain lexical and prosodic cues to the end of the incoming turn. In the presence of an early lexical cue, participants showed earlier gaze shifts toward the target objects and responded faster than in its absence, whereas the presence of a late intonational cue only led to faster response times and did not affect the timing of participants' eye movements. The results show that with a combination of eye-movement and turn-transition time measures it is possible to tease apart the effects of early planning and response initiation on turn timing. They are consistent with models of turn-taking that assume that next speakers (a) start planning their response as soon as the incoming turn's message can be understood and (b) monitor the incoming turn for cues to turn-completion so as to initiate their response when turn-transition becomes relevant.

  8. Cellular Reprogramming–Turning the Clock Back

    Indian Academy of Sciences (India)

    Cellular Reprogramming - Turning the Clock Back - Nobel Prize in Physiology or Medicine, 2012. Deepa Subramanyam ... Keywords. Embryonic stem cells; pluripotency; reprogramming; differentiation; Nobel Prize 2012. ... National Centre for Cell Science University of Pune Campus Ganeshkhind Pune 411 007, India.

  9. Page turning solutions for musicians: a survey.

    Science.gov (United States)

    Wolberg, George; Schipper, Irene

    2012-01-01

    Musicians have long been hampered by the challenge in turning sheet music while their hands are occupied playing an instrument. The sight of a human page turner assisting a pianist during a performance, for instance, is not uncommon. This need for a page turning solution is no less acute during practice sessions, which account for the vast majority of playing time. Despite widespread appreciation of the problem, there have been virtually no robust and affordable products to assist the musician. Recent progress in assistive technology and electronic reading devices offers promising solutions to this long-standing problem. The objective of this paper is to survey the technology landscape and assess the benefits and drawbacks of page turning solutions for musicians. A full range of mechanical and digital page turning products are reviewed.

  10. Derrida’s Turn to Franciscan Philosophy

    Directory of Open Access Journals (Sweden)

    Marko Zlomislic

    2008-12-01

    Full Text Available Contemporary French philosophers such as Levinas, Bataille, and Derrida, along with the existentialists Kierkegaard and Nietzsche have all made use of Franciscan insights in order to safeguard the ipseity that cannot be reduced or totalized. In keeping with the taste that concerns me, this paper will examine Derrida’s turn to the poetry of Gerard Manley Hopkins and how such a turn may place Derrida within a catholic and Franciscan tradition.

  11. The Role of CYP2C8 and CYP2C9 Genotypes in Losartan-Dependent Inhibition of Paclitaxel Metabolism in Human Liver Microsomes.

    Science.gov (United States)

    Mukai, Yuji; Senda, Asuna; Toda, Takaki; Eliasson, Erik; Rane, Anders; Inotsume, Nobuo

    2016-06-01

    The aim of the present study was to further investigate a previously identified metabolic interaction between losartan and paclitaxel, which is one of the marker substrates of CYP2C8, by using human liver microsomes (HLMs) from donors with different CYP2C8 and CYP2C9 genotypes. Although CYP2C8 and CYP2C9 exhibit genetic linkage, previous studies have yet to determine whether losartan or its active metabolite, EXP-3174 which is specifically generated by CYP2C9, is responsible for CYP2C8 inhibition. Concentrations of 6α-hydroxypaclitaxel and EXP-3174 were measured by high-performance liquid chromatography after incubations with paclitaxel, losartan or EXP-3174 in HLMs from seven donors with different CYP2C8 and CYP2C9 genotypes. The half maximal inhibitory concentration (IC50 ) values were not fully dependent on CYP2C8 genotypes. Although the degree of inhibition was small, losartan significantly inhibited the production of 6α-hydroxypaclitaxel at a concentration of 1 μmol/L in only HL20 with the CYP2C8*3/*3 genotype. HLMs with either CYP2C9*2/*2 or CYP2C9*1/*3 exhibited a lower losartan intrinsic clearance (Vmax /Km ) than other HLMs including those with CYP2C9*1/*1 and CYP2C9*1/*2. Significant inhibition of 6α-hydroxypaclitaxel formation by EXP-3174 could only be found at levels that were 50 times higher (100 μmol/L) than the maximum concentration generated in the inhibition study using losartan. These results suggest that the metabolic interaction between losartan and paclitaxel is dependent on losartan itself rather than its metabolite and that the CYP2C8 inhibition by losartan is not affected by the CYP2C9 genotype. Further study is needed to define the effect of CYP2C8 genotypes on losartan-paclitaxel interaction. © 2015 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).

  12. Dietary Caprylic Acid (C8:0 Does Not Increase Plasma Acylated Ghrelin but Decreases Plasma Unacylated Ghrelin in the Rat.

    Directory of Open Access Journals (Sweden)

    Fanny Lemarié

    Full Text Available Focusing on the caprylic acid (C8:0, this study aimed at investigating the discrepancy between the formerly described beneficial effects of dietary medium chain fatty acids on body weight loss and the C8:0 newly reported effect on food intake via ghrelin octanoylation. During 6 weeks, Sprague-Dawley male rats were fed with three dietary C8:0 levels (0, 8 and 21% of fatty acids in three experimental conditions (moderate fat, caloric restriction and high fat. A specific dose-response enrichment of the stomach tissue C8:0 was observed as a function of dietary C8:0, supporting the hypothesis of an early preduodenal hydrolysis of medium chain triglycerides and a direct absorption at the gastric level. However, the octanoylated ghrelin concentration in the plasma was unchanged in spite of the increased C8:0 availability. A reproducible decrease in the plasma concentration of unacylated ghrelin was observed, which was consistent with a decrease in the stomach preproghrelin mRNA and stomach ghrelin expression. The concomitant decrease of the plasma unacylated ghrelin and the stability of its acylated form resulted in a significant increase in the acylated/total ghrelin ratio which had no effect on body weight gain or total dietary consumption. This enhanced ratio measured in rats consuming C8:0 was however suspected to increase (i growth hormone (GH secretion as an increase in the GH-dependent mRNA expression of the insulin like growth Factor 1 (IGF-1 was measured (ii adipocyte diameters in subcutaneous adipose tissue without an increase in the fat pad mass. Altogether, these results show that daily feeding with diets containing C8:0 increased the C8:0 level in the stomach more than all the other tissues, affecting the acylated/total ghrelin plasma ratio by decreasing the concentration of circulating unacylated ghrelin. However, these modifications were not associated with increased body weight or food consumption.

  13. Dietary Caprylic Acid (C8:0) Does Not Increase Plasma Acylated Ghrelin but Decreases Plasma Unacylated Ghrelin in the Rat

    Science.gov (United States)

    Lemarié, Fanny; Beauchamp, Erwan; Dayot, Stéphanie; Duby, Cécile; Legrand, Philippe; Rioux, Vincent

    2015-01-01

    Focusing on the caprylic acid (C8:0), this study aimed at investigating the discrepancy between the formerly described beneficial effects of dietary medium chain fatty acids on body weight loss and the C8:0 newly reported effect on food intake via ghrelin octanoylation. During 6 weeks, Sprague-Dawley male rats were fed with three dietary C8:0 levels (0, 8 and 21% of fatty acids) in three experimental conditions (moderate fat, caloric restriction and high fat). A specific dose-response enrichment of the stomach tissue C8:0 was observed as a function of dietary C8:0, supporting the hypothesis of an early preduodenal hydrolysis of medium chain triglycerides and a direct absorption at the gastric level. However, the octanoylated ghrelin concentration in the plasma was unchanged in spite of the increased C8:0 availability. A reproducible decrease in the plasma concentration of unacylated ghrelin was observed, which was consistent with a decrease in the stomach preproghrelin mRNA and stomach ghrelin expression. The concomitant decrease of the plasma unacylated ghrelin and the stability of its acylated form resulted in a significant increase in the acylated/total ghrelin ratio which had no effect on body weight gain or total dietary consumption. This enhanced ratio measured in rats consuming C8:0 was however suspected to increase (i) growth hormone (GH) secretion as an increase in the GH-dependent mRNA expression of the insulin like growth Factor 1 (IGF-1) was measured (ii) adipocyte diameters in subcutaneous adipose tissue without an increase in the fat pad mass. Altogether, these results show that daily feeding with diets containing C8:0 increased the C8:0 level in the stomach more than all the other tissues, affecting the acylated/total ghrelin plasma ratio by decreasing the concentration of circulating unacylated ghrelin. However, these modifications were not associated with increased body weight or food consumption. PMID:26196391

  14. Dynamics of the reaction of C2 with C6H2: an implication for the formation of interstellar C8H.

    Science.gov (United States)

    Sun, Yi-Lun; Huang, Wen-Jian; Chin, Chih-Hao; Lee, Shih-Huang

    2014-11-21

    The reaction C2 + C6H2 → C8H + H was investigated for the first time. Reactant C2 (C6H2) was synthesized from 1% C3F6/He (5% C2H2/He) by pulsed high-voltage discharge. We measured the translational-energy distribution, the angular distribution, and the photoionization spectrum of product C8H in a crossed molecular-beam apparatus using synchrotron vacuum-ultraviolet ionization. This reaction released average translational energy of 8.5 kcal mol(-1) corresponding to a fraction of 0.37 in translation. C8H was identified as octatetranyl based on the maximal translational-energy release 23 ± 2 kcal mol(-1) and the ionization threshold 8.9 ± 0.2 eV. Kinematic constraints can qualitatively account for the nearly isotropic angular distribution. The quantum-chemical calculations indicate that the exothermic reactions C2 (X (1)Σg (+)/a (3)Πu) + HC6H → C8H + H can proceed without entrance and exit barriers, implying the importance in the cold interstellar medium. This work verifies that interstellar C8H can be formed through the C2 + C6H2 reaction.

  15. Bodily-visual practices and turn continuation.

    Science.gov (United States)

    Ford, Cecilia E; Thompson, Sandra A; Drake, Veronika

    2012-01-01

    This paper considers points in turn construction where conversation researchers have shown that talk routinely continues beyond possible turn completion, but where we find bodily-visual behavior doing such turn extension work. The bodily-visual behaviors we examine share many features with verbal turn extensions, but we argue that embodied movements have distinct properties that make them well-suited for specific kinds of social action, including stance display and by-play in sequences framed as subsidiary to a simultaneous and related verbal exchange. Our study is in line with a research agenda taking seriously the point made by Goodwin (2000a, b, 2003), Hayashi (2003, 2005), Iwasaki (2009), and others that scholars seeking to account for practices in language and social interaction do themselves a disservice if they privilege the verbal dimension; rather, as suggested in Stivers/Sidnell (2005), each semiotic system/modality, while coordinated with others, has its own organization. With the current exploration of bodily-visual turn extensions, we hope to contribute to a growing understanding of how these different modes of organization are managed concurrently and in concert by interactants in carrying out their everyday social actions.

  16. Inhibition of Human Cytochrome P450 2c8-catalyzed Amodiaquine N-desethylation: Effect of Five Traditionally and Commonly Used Herbs.

    Science.gov (United States)

    Muthiah, Yasotha Devi; Ong, Chin Eng; Sulaiman, Siti Amrah; Ismail, Rusli

    2016-01-01

    In Southeast Asia and many parts of the world, herbal products are increasingly used in parallel with modern medicine. This study aimed to investigate the effects of herbs commonly used in Southeast Asia on activity of cytochrome P450 2C8 (CYP2C8), an important human hepatic enzyme in drug metabolism. The selected herbs, such as Eurycoma longifolia Jack (ELJ), Labisia pumila (LP), Echinacea purpurea (EP), Andrographis paniculata (AP), and Ginkgo biloba (GB), were subjected to inhibition studies using an in vitro CYP2C8 activity marker, amodiaquine N-desethylase assay. Inhibition parameters, inhibitory concentration 50% (IC50), and Ki values were determined to study the potency and mode of inhibition. All herbs inhibited CYP2C8 with the following order of potency: LP > ELJ > GB > AP > EP. LP and ELJ inhibited potently at Ki's of 2 and 4 times the Ki of quercetin, the positive control. The inhibition by LP was uncompetitive in nature as compared to competitive or mixed type inhibition observed with other herbs. GB exhibited moderate inhibitory effect at a Ki6 times larger than quercetin Ki. AP and EP, on the other hand, showed only weak inhibition. The herbs we chose represented the more commonly used herbs in Southeast Asia where collision of tradition and modernization in healthcare, if not properly managed, may lead to therapeutic misadventures. We conclude that concurrent consumption of some herbs, in particular, LP and ELJ, may have relevance in drug-herb interactions via CYP2C8 inhibition in vivo. Herbs are increasingly used in parallel with modern medicines nowadays. In this study five commonly used herbs in Southeast Asia region, ELJ, LP, EP, AP and GB, were investigated for their in vitro inhibitory potency on CYP2C8, an important drug-metaboliz-ing human hepatic enzyme. All herbs inhibited CYP2C8 activity marker, amodiaquine N-desethylation, with potency order of LP > ELJ > GB >AP > EP. LP, ELJ and GB exhibited Ki values of 2, 4 and 6 times the Ki of

  17. Turning points in the history of mathematics

    CERN Document Server

    Grant, Hardy

    2015-01-01

    This book explores some of the major turning points in the history of mathematics, ranging from ancient Greece to the present, demonstrating the drama that has often been a part of its evolution. Studying these breakthroughs, transitions, and revolutions, their stumbling-blocks and their triumphs, can help illuminate the importance of the history of mathematics for its teaching, learning, and appreciation. Some of the turning points considered are the rise of the axiomatic method (most famously in Euclid), and the subsequent major changes in it (for example, by David Hilbert); the “wedding,” via analytic geometry, of algebra and geometry; the “taming” of the infinitely small and the infinitely large; the passages from algebra to algebras, from geometry to geometries, and from arithmetic to arithmetics; and the revolutions in the late nineteenth and early twentieth centuries that resulted from Georg Cantor’s creation of transfinite set theory. The origin of each turning point is discussed, along with...

  18. Market turning points forecasting using wavelet analysis

    Science.gov (United States)

    Bai, Limiao; Yan, Sen; Zheng, Xiaolian; Chen, Ben M.

    2015-11-01

    Based on the system adaptation framework we previously proposed, a frequency domain based model is developed in this paper to forecast the major turning points of stock markets. This system adaptation framework has its internal model and adaptive filter to capture the slow and fast dynamics of the market, respectively. The residue of the internal model is found to contain rich information about the market cycles. In order to extract and restore its informative frequency components, we use wavelet multi-resolution analysis with time-varying parameters to decompose this internal residue. An empirical index is then proposed based on the recovered signals to forecast the market turning points. This index is successfully applied to US, UK and China markets, where all major turning points are well forecasted.

  19. CONNECTION OF TURN AHEAD AND TURN BACK WITH MOTORIC ABILITIES OF THE FIFTH GRADE STUDENTS

    Directory of Open Access Journals (Sweden)

    Jovica Petković

    2006-06-01

    Full Text Available The research is done for the purpose of determination and defining of the level of connection between some motoric abilities with success in realization of programmed contents from the area of gymnastics (turn ahead and turn back. The research is done on the sample of fifty one students from the fifth grade of Elementary School, on ten motoric tests and on two specific motoric assignments – turn ahead and turn back. The results of this research clearly point that there exist the multitude of statistically important coefficients of correlation between treated motoric abilities and applied motoric assignments.

  20. C8-Selective Acylation of Quinoline N-Oxides with α-Oxocarboxylic Acids via Palladium-Catalyzed Regioselective C-H Bond Activation.

    Science.gov (United States)

    Chen, Xiaopei; Cui, Xiuling; Wu, Yangjie

    2016-08-05

    A facile and efficient protocol for palladium-catalyzed C8-selective acylation of quinoline N-oxides with α-oxocarboxylic acids has been developed. In this approach, N-oxide was utilized as a stepping stone for the remote C-H functionalization. The reactions proceeded efficiently under mild reaction conditions with excellent regioselectivity and broad functional group tolerance.

  1. Conserved phosphoryl transfer mechanisms within kinase families and the role of the C8 proton of ATP in the activation of phosphoryl transfer

    Directory of Open Access Journals (Sweden)

    Kenyon Colin P

    2012-03-01

    Full Text Available Abstract Background The kinome is made up of a large number of functionally diverse enzymes, with the classification indicating very little about the extent of the conserved kinetic mechanisms associated with phosphoryl transfer. It has been demonstrated that C8-H of ATP plays a critical role in the activity of a range of kinase and synthetase enzymes. Results A number of conserved mechanisms within the prescribed kinase fold families have been identified directly utilizing the C8-H of ATP in the initiation of phosphoryl transfer. These mechanisms are based on structurally conserved amino acid residues that are within hydrogen bonding distance of a co-crystallized nucleotide. On the basis of these conserved mechanisms, the role of the nucleotide C8-H in initiating the formation of a pentavalent intermediate between the γ-phosphate of the ATP and the substrate nucleophile is defined. All reactions can be clustered into two mechanisms by which the C8-H is induced to be labile via the coordination of a backbone carbonyl to C6-NH2 of the adenyl moiety, namely a "push" mechanism, and a "pull" mechanism, based on the protonation of N7. Associated with the "push" mechanism and "pull" mechanisms are a series of proton transfer cascades, initiated from C8-H, via the tri-phosphate backbone, culminating in the formation of the pentavalent transition state between the γ-phosphate of the ATP and the substrate nucleophile. Conclusions The "push" mechanism and a "pull" mechanism are responsible for inducing the C8-H of adenyl moiety to become more labile. These mechanisms and the associated proton transfer cascades achieve the proton transfer via different family-specific conserved sets of amino acids. Each of these mechanisms would allow for the regulation of the rate of formation of the pentavalent intermediate between the ATP and the substrate nucleophile. Phosphoryl transfer within kinases is therefore a specific event mediated and regulated via the

  2. The dynamic turn in quantum logic

    NARCIS (Netherlands)

    Baltag, Alexandru; Smets, Sonja

    In this paper we show how ideas coming from two areas of research in logic can reinforce each other. The first such line of inquiry concerns the "dynamic turn" in logic and especially the formalisms inspired by Propositional Dynamic Logic (PDL); while the second line concerns research into the

  3. Leadership Helps Turn around a Troubled School

    Science.gov (United States)

    Sheppard, Von

    2013-01-01

    The author tells how he employed leadership skills to help turn around a failing school loaded with at-risk students. Dayton's Bluff Elementary School was one of the worst in St. Paul when Von Sheppard took over as principal in 2001. Changing the staff and attitudes at the largely low-income, minority majority school in a tough neighborhood helped…

  4. Train turn restrictions and line plan performance

    DEFF Research Database (Denmark)

    Burggraeve, Sofie; Bull, Simon Henry; Lusby, Richard Martin

    In this paper we study the impact of the `turn conditions' in end stations on the performance of a line plan. If trains have to turn on their platform in an end station, the yoccupy the platform for several minutes. A more preferred option, from a timetabling point of view, would be that a train...... disappears from the platform in its end station after dwelling and only appears again when departing for a subsequent trip. In this case, the train will not interfere with other trains that dwell on the platform during the time between these events. However, this option is only possible if the train can stay...... in a exible and large enough shunt. Starting from a given line plan, we compare two timetables, one where trains have to turn on their platform and one where trains can turn in a shunt. We evaluate the impact on the performance of the line plan by its feasibility for timetabling,the minimum overall buffer...

  5. Face to Face Turning A New Leaf

    Indian Academy of Sciences (India)

    Face to Face. Thissectionfeaturesconversationswithpersonalitiesrelated to science, highlighting the factors and circumstances that guided them in making the career choice to be a scientist. Turning A New Leaf. H Y Mohan Ram talks to Sujata Varadarajan. Prof. H Y Mohan Ram is a man of myriad interests and talents and is ...

  6. Strategy in Generative Planning of Turning Processes

    NARCIS (Netherlands)

    van Houten, Frederikus J.A.M.; Kals, H.J.J.

    1986-01-01

    This paper reports on the process and operations planning system ROUND and the strategies which underlie the decision making processes in the planning of turning operations. At first, an outline is given about the environment for which generative systems like ROUND are being developed. The

  7. Business Intelligence: Turning Knowledge into Power

    Science.gov (United States)

    Endsley, Krista

    2009-01-01

    Today, many school districts are turning to business intelligence tools to retrieve, organize, and share knowledge for faster analysis and more effective, guided decision making. Business intelligence (BI) tools are the technologies and applications that gather and report information to help an organization's leaders make better decisions. BI…

  8. The experience turn as ‘bandwagon’

    DEFF Research Database (Denmark)

    Fuglsang, Lars; Eide, Dorthe

    2013-01-01

    This paper uses the bandwagon metaphor to analyse, in two rural contexts, how small tourism firms become engaged in the idea of the experience economy and how the idea is turned into practice through network formation and innovation. In developing a practice-based approach we use the bandwagon...

  9. Efficacy of piroxicam for postoperative pain after lower third molar surgery associated with CYP2C8*3 and CYP2C9

    Directory of Open Access Journals (Sweden)

    Calvo AM

    2017-07-01

    Full Text Available Adriana Maria Calvo, Paulo Zupelari-Gonçalves, Thiago José Dionísio, Daniel Thomas Brozoski, Flávio Augusto Faria, Carlos Ferreira Santos Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, São Paulo, Brazil Objective: Nonsteroidal anti-inflammatory drugs (NSAIDs are metabolized by the cytochrome P450 enzymes (CYPs, predominantly CYP2C8 and CYP2C9. The aim of this study was to evaluate the possible association of polymorphisms in the CYP2C8*3 and CYP2C9 genes with the clinical efficacy of oral piroxicam (20 mg daily for 4 days after lower third molar surgeries with regard to postoperative pain, swelling, trismus, adverse reactions, need for rescue medication and the volunteer’s overall satisfaction. Materials and methods: For this purpose, 102 volunteers were genotyped for CYP2C8*3 and CYP2C9 polymorphisms. Briefly, genomic DNA was isolated from saliva collected from volunteers subjected to invasive lower third molar surgeries, and the preoperative, intraoperative and postoperative parameters were collected and analyzed. Results: An equal amount of piroxicam sufficiently managed postoperative pain and inflammatory symptoms, with visual analog pain scores typically <40 mm for all genotypes investigated. Furthermore, only two out of 102 volunteers heterozygous for CYP2C8*3 and CYP2C9*3 reported adverse side effects. Conclusion: In general, slow metabolizers of piroxicam, who were volunteers with mutant alleles, were indifferent from normal metabolizers with the wild-type alleles and therefore did not require specialized piroxicam doses to manage postoperative pain and inflammation. Keywords: piroxicam, lower third molar surgery, P450, CYP2C8, CYP2C9, pharmacogenetics 

  10. -and -turns in proteins revisited: A new set of amino acid turn ...

    Indian Academy of Sciences (India)

    -turns (7153) and -turns (911) extracted from these proteins were used to derive a revised set of type-dependent amino acid positional preferences and potentials. Compared with previous results, the preference for proline, methionine and tryptophan has increased and the preference for glutamine, valine, glutamic acid ...

  11. Driving simulator study of J-Turn acceleration/deceleration lane and U-turn spacing.

    Science.gov (United States)

    2016-11-01

    Carlos Sun : http://orcid.org/0000-0002-8857-9648 : The J-turn, also known as RCUT (Restricted Crossing U-Turn) and Superstreet, is an innovative geometric design that can improve intersection safety. Even though this design has been in use in severa...

  12. Immediate Effects of Clock-Turn Strategy on the Pattern and Performance of Narrow Turning in Persons With Parkinson Disease.

    Science.gov (United States)

    Yang, Wen-Chieh; Hsu, Wei-Li; Wu, Ruey-Meei; Lin, Kwan-Hwa

    2016-10-01

    Turning difficulty is common in people with Parkinson disease (PD). The clock-turn strategy is a cognitive movement strategy to improve turning performance in people with PD despite its effects are unverified. Therefore, this study aimed to investigate the effects of the clock-turn strategy on the pattern of turning steps, turning performance, and freezing of gait during a narrow turning, and how these effects were influenced by concurrent performance of a cognitive task (dual task). Twenty-five people with PD were randomly assigned to the clock-turn or usual-turn group. Participants performed the Timed Up and Go test with and without concurrent cognitive task during the medication OFF period. The clock-turn group performed the Timed Up and Go test using the clock-turn strategy, whereas participants in the usual-turn group performed in their usual manner. Measurements were taken during the 180° turn of the Timed Up and Go test. The pattern of turning steps was evaluated by step time variability and step time asymmetry. Turning performance was evaluated by turning time and number of turning steps. The number and duration of freezing of gait were calculated by video review. The clock-turn group had lower step time variability and step time asymmetry than the usual-turn group. Furthermore, the clock-turn group turned faster with fewer freezing of gait episodes than the usual-turn group. Dual task increased the step time variability and step time asymmetry in both groups but did not affect turning performance and freezing severity. The clock-turn strategy reduces turning time and freezing of gait during turning, probably by lowering step time variability and asymmetry. Dual task compromises the effects of the clock-turn strategy, suggesting a competition for attentional resources.Video Abstract available for more insights from the authors (see Supplemental Digital Content 1, http://links.lww.com/JNPT/A141).

  13. Effect of turning angle on performance of 2-D turning diffuser via Asymptotic Computational Fluid Dynamics

    Science.gov (United States)

    Khong, Y. T.; Nordin, N.; Seri, S. M.; Mohammed, A. N.; Sapit, A.; Taib, I.; Abdullah, K.; Sadikin, A.; Razali, M. A.

    2017-09-01

    The present work aims to numerically investigate the effect of varying turning angle, ϕ = 30° - 90° on the performance of 2-D turning diffuser and to develop the performance correlations via integrating the turning angle using Asymptotic Computational Fluid Dynamics (ACFD) technique. Standard k-ε adopting enhanced wall treatment of y+ ≈ 1.1 appeared as the best validated model to represent the actual cases with deviation of ±4.7%. Results show that the pressure recovery, Cp and flow uniformity, σout are distorted of respectively 37% and 28% with the increment of turning angle from 30° to 90°. The flow separation starts to emerge within the inner wall, S=0.91Lin/W1 when 45° turning diffuser is applied and its scale is enlarged by further increasing the turning angle. The performance correlations of 2-D turning diffuser are successfully developed with deviation to the full CFD solution approximately of ±7.1%.

  14. Measurement of tool forces in diamond turning

    Energy Technology Data Exchange (ETDEWEB)

    Drescher, J.; Dow, T.A.

    1988-12-01

    A dynamometer has been designed and built to measure forces in diamond turning. The design includes a 3-component, piezoelectric transducer. Initial experiments with this dynamometer system included verification of its predicted dynamic characteristics as well as a detailed study of cutting parameters. Many cutting experiments have been conducted on OFHC Copper and 6061-T6 Aluminum. Tests have involved investigation of velocity effects, and the effects of depth and feedrate on tool forces. Velocity has been determined to have negligible effects between 4 and 21 m/s. Forces generally increase with increasing depth of cut. Increasing feedrate does not necessarily lead to higher forces. Results suggest that a simple model may not be sufficient to describe the forces produced in the diamond turning process.

  15. When attempts at robbing prey turn fatal

    Science.gov (United States)

    Dejean, Alain; Corbara, Bruno; Azémar, Frédéric; Carpenter, James M.

    2012-07-01

    Because group-hunting arboreal ants spread-eagle insect prey for a long time before retrieving them, these prey can be coveted by predatory flying insects. Yet, attempting to rob these prey is risky if the ant species is also an effective predator. Here, we show that trying to rob prey from Azteca andreae workers is a fatal error as 268 out of 276 potential cleptobionts (97.1 %) were captured in turn. The ant workers hunt in a group and use the "Velcro®" principle to cling firmly to the leaves of their host tree, permitting them to capture very large prey. Exceptions were one social wasp, plus some Trigona spp. workers and flies that landed directly on the prey and were able to take off immediately when attacked. We conclude that in this situation, previously captured prey attract potential cleptobionts that are captured in turn in most of the cases.

  16. Turning Mechanics During Swimming by Oblate Hydromedusae

    Science.gov (United States)

    Costello, J.; Colin, S.; Sutherland, K.; Gemmell, B. J.

    2016-02-01

    Maneuverability is critical to the success of many species. Selective forces acting over millions of years have resulted in a range of capabilities currently unmatched by machines. Thus, understanding animal control of fluids for maneuvering has both biological and engineering applications. Medusae are radially symmetrical swimmers that must use asymmetric body motions to change direction during turning maneuvers. But what types of asymmetric motions are useful and how do they interact with surrounding fluids to generate rotational forces? We used high speed digital particle image velocimetry (DPIV) to investigate comparative swimming patterns of three hydromedusan species (Aequorea victoria, Clytia gregaria and Mitrocoma cellularia). We provide evidence for consistent animal-fluid interactions that underlie turning mechanics of oblate hydromedusae and provide new insights into the modulation and control of vorticity for low-speed animal maneuvering.

  17. Dynamics of a steel turning process

    Science.gov (United States)

    Litak, Grzegorz; Rusinek, Rafał

    This paper explores the cutting force oscillations. Forces have been measured during the stainless steel turning. We provide the results of standard statistical analysis of the corresponding time series together with their recurrence properties. We claim that the system, which is initially in a regular vibration region for some fairly larger cutting depth, is unstable to chaotic oscillation appearance. This could have the important implication to the process control procedure.

  18. Turning neurons into a nervous system.

    Science.gov (United States)

    Grove, Elizabeth A

    2008-07-01

    The RIKEN Center for Developmental Biology recently held its 2008 Symposium ;Turning Neurons into a Nervous System' in Kobe, Japan. The program, organized by Masatoshi Takeichi, Joshua Sanes, Hideki Enomoto and Raj Ladher, provided a rich sampling from current work in developmental neurobiology. Researchers from Japan, Europe and the USA gathered at this meeting to share insights into neural development and to admire the opening of the cherry blossom season.

  19. Rekayasa Cnc Turning Sebagai Media Pembelajaran Cnc

    OpenAIRE

    Purwoko, Bambang Setiyo Hari

    2016-01-01

    Engineering CNC Turning aims; (1) produce a prototype, which is capable of a teaching aids, and resources of CNC programming. Engineering conducted following the procedures Research and Development (R & D) expressed Borg and Gall. Starting with a needs study of teaching aids/media of CNC programming; defining products (define); designing a system and form (design); develop products and test its performance (develop); and the revision/ improvement of product performance (revise). Results of th...

  20. Turning points in climate change adaptation

    Directory of Open Access Journals (Sweden)

    Saskia Elisabeth. Werners

    2015-12-01

    Full Text Available Concerned decision makers increasingly pose questions as to whether current management practices are able to cope with climate change and increased climate variability. This signifies a shift in the framing of climate change from asking what its potential impacts are to asking whether it induces policy failure and unacceptable change. In this paper, we explore the background, feasibility, and consequences of this new framing. We focus on the specific situation in which a social-political threshold of concern is likely to be exceeded as a result of climate change, requiring consideration of alternative strategies. Action is imperative when such a situation is conceivable, and at this point climate change becomes particularly relevant to decision makers. We call this situation an "adaptation turning point." The assessment of adaptation turning points converts uncertainty surrounding the extent of a climate impact into a time range over which it is likely that specific thresholds will be exceeded. This can then be used to take adaptive action. Despite the difficulty in identifying adaptation turning points and the relative newness of the approach, experience so far suggests that the assessment generates a meaningful dialogue between stakeholders and scientists. Discussion revolves around the amount of change that is acceptable; how likely it is that unacceptable, or more favorable, conditions will be reached; and the adaptation pathways that need to be considered under these circumstances. Defining and renegotiating policy objectives under climate change are important topics in the governance of adaptation.

  1. FCC-hh turn-around cycle

    CERN Document Server

    Alemany Fernandez, Reyes; Bartmann, Wolfgang; Buffat, Xavier; Niemi, Arto; Schulte, Daniel; Solfaroli Camillocci, Matteo; Stoel, Linda

    2016-01-01

    The turn-around cycle time of a collider is defined as the time spent between the end of stable beams and the start of the next stable beams period, and its calculation is of fundamental importance. On one side it is a crucial ingredient for the computation of the optimal time spent in luminosity production, which defines the integrated luminosity per fill or store. On the other side, combined with the availability and reliability of the machine, it allows to perform a detailed breakdown of the operational performance of the collider over an operational season, i.e. percentage of time in stable beams and beam in the machine with respect to down time. This paper presents a preliminary operational cycle definition for the hadron-hadron Future Circular Collider, as a base line for estimating the corresponding turn-around time. The cycle definition is based on the Large Hadron Collider (LHC) operational cycle. Two turn-around times are presented, the theoretical one and a more realistic one based on the LHC exper...

  2. Effect of concomitant artesunate administration and cytochrome P4502C8 polymorphisms on the pharmacokinetics of amodiaquine in Ghanaian children with uncomplicated malaria

    DEFF Research Database (Denmark)

    Adjei, George O; Kristensen, Kim; Goka, Bamenla Q

    2008-01-01

    implications for weight-based dosing of higher-body-weight children with AQ. The pharmacokinetics of artemisinin combination therapies should be studied in malaria patients, because the rapid parasite clearance caused by the artemisinin may affect the kinetics of the partner drug and the combination.......Artesunate (AS) is used in combination with amodiaquine (AQ) as first-line treatment for uncomplicated malaria in many countries. We investigated the effect of concomitant AS administration on the pharmacokinetics of AQ and compared concentrations of desethylamodiaquine (DEAQ), the main metabolite...... of AQ, in plasma between patients with different variants of the cytochrome P4502C8 (CYP2C8) gene. A two-compartment model was fitted to 169 plasma DEAQ concentrations from 103 Ghanaian children aged 1 to 14 years with uncomplicated malaria treated either with AQ alone (n = 15) or with AS plus AQ (n...

  3. Molecular-scale observation of YD2-o-C8 self-assembled monolayer on TiO2 (1 1 0)

    Science.gov (United States)

    Li, Ya-Juan; Sun, Lei; Jiang, Lei; Zhou, Qin; Ma, Zhi-Bo; Yang, Xue-Ming; Deng, Wei-Qiao

    2017-11-01

    The self-assembled monolayer (SAM) on TiO2 nanocrystal surface plays an important role in the processes of photoelectric conversion in dye sensitized solar cells (DSSCs). The SAM of dye YD2-o-C8, which was the best dye for DSSCs, has been observed by scanning tunneling microscope (STM) at molecular scale for the first time. The observation results showed that different morphologies of YD2-o-C8 SAM can be formed with or without chenodeoxycholic acid (cheno), which determined their corresponding photovoltaic cell efficiencies. The density functional theory (DFT) calculations explored the reason that was caused by the reduced electron coupling between side-to-side dimers separated by cheno molecules.

  4. Experimental and mechanistic analysis of the palladium-catalyzed oxidative C8-selective C-H homocoupling of quinoline N-oxides.

    Science.gov (United States)

    Stephens, David E; Lakey-Beitia, Johant; Chavez, Gabriel; Ilie, Carla; Arman, Hadi D; Larionov, Oleg V

    2015-06-11

    A novel site-selective palladium-catalyzed oxidative C8-H homocoupling reaction of quinoline N-oxides has been developed. The reaction affords substituted 8,8'-biquinolyl N,N'-dioxides that can be readily converted to a variety of functionalized 8,8'-biquinolyls. Mechanistic studies point to the crucial role of the oxidant and a non-innocent behavior of acetic acid as a solvent.

  5. Are Cytochrome P450 CYP2C8 and CYP2C9 Polymorphisms Associated with Ibuprofen Response in Very Preterm Infants?

    Science.gov (United States)

    Médard, Yves; Jacqz-Aigrain, Evelyne; Decobert, Fabrice; Barre, Jérome; Alberti, Corinne; Aujard, Yannick

    2010-01-01

    Background Patent ductus arteriosus (PDA) in extremely preterm infants remains a challenging condition with conflicting treatment strategies. Ibuprofen is currently used to treat PDA with ductal closure failure rate up to 40%. We test the hypothesis that cytochrome P450 CYP2C8/2C9 polymorphisms may predict ibuprofen response. Methodology/Principal Findings We studied extremely preterm neonates with haemodynamically significant PDA and treated with ibuprofen. One or two variant CYP2C8 and/or 2C9 alleles were found in 17% of the population, most of them were from Caucasian ethnicity (67–74%). Response to ibuprofen and clinical course of infants carrying variants CYP2C8 and CYP2C9 were similar. Comparing infants with wild type or variant CYP2C8 and CYP2C9 genotypes, response rate to ibuprofen was significantly higher in wild type than in mutated carriers in univariate analysis (73% versus 52%, p = 0.04). Comparing responders (ductus closure; n = 75) and non-responders (surgical ligation; n = 36), the only two factors significantly associated with the response to ibuprofen using multivariate analysis were higher gestational age and non Caucasian ethnicity but not CYP2C polymorphism. Conclusions CYP2C polymorphism was not associated with PDA response to ibuprofen and this factor appears not appropriate to optimize the ductal closure rate by modulating ibuprofen dosing strategy. This study points out the role for ethnicity in the interindividual variability of response to ibuprofen in extremely preterm infants. PMID:20808793

  6. Lattice modeling and calibration with turn-by-turn orbit data

    Directory of Open Access Journals (Sweden)

    Xiaobiao Huang

    2010-11-01

    Full Text Available A new method that explores turn-by-turn beam position monitor (BPM data to calibrate lattice models of accelerators is proposed. The turn-by-turn phase space coordinates at one location of the ring are first established using data from two BPMs separated by a simple section with a known transfer matrix, such as a drift space. The phase space coordinates are then tracked with the model to predict positions at other BPMs, which can be compared to measurements. The model is adjusted to minimize the difference between the measured and predicted orbit data. BPM gains and rolls are included as fitting variables. This technique can be applied to either the entire or a section of the ring. We have tested the method experimentally on a part of the SPEAR3 ring.

  7. Understanding the Electronic Structures and Absorption Properties of Porphyrin Sensitizers YD2 and YD2-o-C8 for Dye-Sensitized Solar Cells

    Science.gov (United States)

    Han, Li-Heng; Zhang, Cai-Rong; Zhe, Jian-Wu; Jin, Neng-Zhi; Shen, Yu-Lin; Wang, Wei; Gong, Ji-Jun; Chen, Yu-Hong; Liu, Zi-Jiang

    2013-01-01

    The electronic structures and excitation properties of dye sensitizers determine the photon-to-current conversion efficiency of dye sensitized solar cells (DSSCs). In order to understand the different performance of porphyrin dye sensitizers YD2 and YD2-o-C8 in DSSC, their geometries and electronic structures have been studied using density functional theory (DFT), and the electronic absorption properties have been investigated via time-dependent DFT (TDDFT) with polarizable continuum model for solvent effects. The geometrical parameters indicate that YD2 and YD2-o-C8 have similar conjugate length and charge transfer (CT) distance. According to the experimental spectra, the HSE06 functional in TDDFT is the most suitable functional for describing the Q and B absorption bands of porphyrins. The transition configurations and molecular orbital analysis suggest that the diarylamino groups are major chromophores for effective CT excitations (ECTE), and therefore act as electron donor in photon-induced electron injection in DSSCs. The analysis of excited states properties and the free energy changes for electron injection support that the better performance of YD2-o-C8 in DSSCs result from the more excited states with ECTE character and the larger absolute value of free energy change for electron injection. PMID:24152435

  8. Understanding the Electronic Structures and Absorption Properties of Porphyrin Sensitizers YD2 and YD2-o-C8 for Dye-Sensitized Solar Cells

    Directory of Open Access Journals (Sweden)

    Zi-Jiang Liu

    2013-10-01

    Full Text Available The electronic structures and excitation properties of dye sensitizers determine the photon-to-current conversion efficiency of dye sensitized solar cells (DSSCs. In order to understand the different performance of porphyrin dye sensitizers YD2 and YD2-o-C8 in DSSC, their geometries and electronic structures have been studied using density functional theory (DFT, and the electronic absorption properties have been investigated via time-dependent DFT (TDDFT with polarizable continuum model for solvent effects. The geometrical parameters indicate that YD2 and YD2-o-C8 have similar conjugate length and charge transfer (CT distance. According to the experimental spectra, the HSE06 functional in TDDFT is the most suitable functional for describing the Q and B absorption bands of porphyrins. The transition configurations and molecular orbital analysis suggest that the diarylamino groups are major chromophores for effective CT excitations (ECTE, and therefore act as electron donor in photon-induced electron injection in DSSCs. The analysis of excited states properties and the free energy changes for electron injection support that the better performance of YD2-o-C8 in DSSCs result from the more excited states with ECTE character and the larger absolute value of free energy change for electron injection.

  9. A novel fluorescent "Turn-Off/Turn-On" system for the detection of acid phosphatase activity.

    Science.gov (United States)

    Guo, Pu; Yan, Shengyong; Zhou, Yimin; Wang, Changcheng; Xu, Xiaowei; Weng, Xiaocheng; Zhou, Xiang

    2013-06-21

    Acid phosphatase (ACP) can be sensitively, conveniently and efficiently detected via a new fluorescent "Turn-Off/Turn-On" system. Inexpensive (NaPO(3))(6) is carefully introduced into this system as a quencher of the aggregation-caused quenching (ACQ) probe. In our method, the limit of detection (LOD) is quite low for detecting ACP, which is an important biomarker and indication of several diseases.

  10. Atmospheric histories and growth trends of C4F10, C5F12, C6F14, C7F16 and C8F18

    Directory of Open Access Journals (Sweden)

    R. F. Weiss

    2012-05-01

    Full Text Available Atmospheric observations and trends are presented for the high molecular weight perfluorocarbons (PFCs: decafluorobutane (C4F10, dodecafluoropentane (C5F12, tetradecafluorohexane (C6F14, hexadecafluoroheptane (C7F16 and octadecafluorooctane (C8F18. Their atmospheric histories are based on measurements of 36 Northern Hemisphere and 46 Southern Hemisphere archived air samples collected between 1973 to 2011 using the Advanced Global Atmospheric Gases Experiment (AGAGE "Medusa" preconcentration gas chromatography-mass spectrometry systems. A new calibration scale was prepared for each PFC, with estimated accuracies of 6.8% for C4F10, 7.8% for C5F12, 4.0% for C6F14, 6.6% for C7F16 and 7.9% for C8F18. Based on our observations the 2011 globally averaged dry air mole fractions of these heavy PFCs are: 0.17 parts-per-trillion (ppt, i.e., parts per 1012 for C4F10, 0.12 ppt for C5F12, 0.27 ppt for C6F14, 0.12 ppt for C7F16 and 0.09 ppt for C8F18. These atmospheric mole fractions combine to contribute to a global average radiative forcing of 0.35 mW m−2, which is 6% of the total anthropogenic PFC radiative forcing (Montzka and Reimann, 2011; Oram et al., 2012. The growth rates of the heavy perfluorocarbons were largest in the late 1990s peaking at 6.2 parts per quadrillion (ppq, i.e., parts per 1015 per year (yr for C4F10, at 5.0 ppq yr−1 for C5F12 and 16.6 ppq yr−1 for C6F14 and in the early 1990s for C7F16 at 4.7 ppq yr−1 and in the mid 1990s for C8F18 at 4.8 ppq yr−1. The 2011 globally averaged mean atmospheric growth rates of these PFCs are subsequently lower at 2.2 ppq yr−1 for C4F10, 1.4 ppq yr−1 for C5F12, 5.0 ppq yr−1 for C6F14, 3.4 ppq yr−1 for C7F16 and 0.9 ppq yr−1 for C8F18. The more recent slowdown in the growth rates suggests that emissions are declining as compared to the 1980s and 1990s.

  11. Turning the Appliance Market Around towards A++

    DEFF Research Database (Denmark)

    Nørgaard, Jørgen; Brange, Birgitte; Guldbrandsen, Tom

    2007-01-01

    energy efficient model within their specification, and 4) in the website are also listed the shops, where consumers can get the appliances at lowest prices. The latter was the most innovative and maybe also the most effective measure in the package. Results showed up as a permanent U-turn of the market...... in the course of a few years. Where models C, D, E earlier dominated the market, the A, A+ and A++, came to dominate as the standard models in stock. Consequently, their prices dropped significantly. The theory of a rational market behavior is based on some assumptions, one being that full information...

  12. The turn-around of Uninor

    OpenAIRE

    Gooderham, Paul N.; Ulset, Svein

    2013-01-01

    On October 29, 2008, Telenor of Norway announced its plans to enter the Indian mobile telecom market. Despite a strong start, revenue did not grow in line with business projections. In a highly congested market, price war caused rapidly shrinking margins. Something radical had to be done and quickly. A new cost-focused management team, headed by Telenor’s Asia chief Sigve Brekke, was appointed. In record time, they managed to turn Uninor into a dedicated ultra-low-cost basic services provide...

  13. Hatchability of chicken eggs as influenced by turning frequency in ...

    African Journals Online (AJOL)

    An experiment was conducted to determine the influence of turning frequency of chicken eggs on hatchability in hurricane lantern incubator. There were four treatments in which eggs were not turned in treatment one (control), those in treatment two were turned once daily (morning), treatment three turned twice daily ...

  14. Curious terminal turn of rolling rings

    CERN Document Server

    Jalali, Mir Abbas; Alam, Reza

    2014-01-01

    We report an unexpected reverse spiral turn in the final stage of the motion of rolling rings. It is well known that spinning disks have definite centers of rotation until they stop. While a spinning ring starts its motion with a similar kinematics, moving along a cycloidal path prograde with the direction of its rigid body rotation, the mean trajectory of its center of mass develops an inflection point so that the ring makes a spiral turn and revolves in a retrograde direction around a new center. Using high speed imaging and numerical simulations of models featuring a rolling rigid body, we show that the hollow geometry of a ring tunes the rotational air drag resistance so that the frictional force at the contact point with the ground changes its direction at the inflection point and puts the ring on a retrograde spiral trajectory. Our findings have potential applications in designing topologically new surface-effect flying objects capable of performing complex reorientation and translational maneuvers.

  15. ββ- and γγ-turns in proteins revisited: A new set of amino acid turn ...

    Indian Academy of Sciences (India)

    The number of β-turns in a representative set of 426 protein three-dimensional crystal structures selected from the re- cent Protein Data Bank has nearly doubled and the number of γ-turns in a representative set of 320 proteins has in- creased over seven times since the previous analysis. β-turns (7153) and γ-turns (911) ...

  16. K2C8 METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  17. Determinants of Cytochrome P450 2C8 Substrate Binding: Structures of Complexes With Montelukast, Troglitazone, Felodipine And 9-CIS-Retinoic Acid

    Energy Technology Data Exchange (ETDEWEB)

    Schoch, G.A.; Yano, J.K.; Dansette, P.M.; Stout, C.D.; Johnson, E.F.

    2009-05-27

    Although a crystal structure and a pharmacophore model are available for cytochrome P450 2C8, the role of protein flexibility and specific ligand-protein interactions that govern substrate binding are poorly understood. X-ray crystal structures of P450 2C8 complexed with montelukast (2.8 {angstrom}), troglitazone (2.7 {angstrom}), felodipine (2.3 {angstrom}), and 9-cis-retinoic acid (2.6 {angstrom}) were determined to examine ligand-protein interactions for these chemically diverse compounds. Montelukast is a relatively large anionic inhibitor that exhibits a tripartite structure and complements the size and shape of the active-site cavity. The inhibitor troglitazone occupies the upper portion of the active-site cavity, leaving a substantial part of the cavity unoccupied. The smaller neutral felodipine molecule is sequestered with its dichlorophenyl group positioned close to the heme iron, and water molecules fill the distal portion of the cavity. The structure of the 9-cis-retinoic acid complex reveals that two substrate molecules bind simultaneously in the active site of P450 2C8. A second molecule of 9-cis-retinoic acid is located above the proximal molecule and can restrain the position of the latter for more efficient oxygenation. Solution binding studies do not discriminate between cooperative and noncooperative models for multiple substrate binding. The complexes with structurally distinct ligands further demonstrate the conformational adaptability of active site-constituting residues, especially Arg-241, that can reorient in the active-site cavity to stabilize a negatively charged functional group and define two spatially distinct binding sites for anionic moieties of substrates.

  18. Conserved phosphoryl transfer mechanisms within kinase families and the role of the C8 proton of ATP in the activation of phosphoryl transfer

    CSIR Research Space (South Africa)

    Kenyon, CP

    2012-03-01

    Full Text Available , with the concomitant re-protonation of C8. Groups 8 There is only one member in each of Group 8, Group 9, Group 10 and Group 11 kinases. Group 8 consists of ribo- flavin kinase from Schizosaccharomyces pombe and Homo sapiens (flavokinase family) (Additional file 1... 3) in that the latter two are pyrophosphotrans- ferases transferring a pyrophosphate group from a nucleo- side triphosphate, such as ATP to the hydroxyl of thiamine. All enzymes in Group 7 are homo-dimeric, with the active site comprising amino...

  19. Heat of Mixing and Solution of 2-Methylpropan-2-ol C4H10O + C8H18 Octane (HMSD1111, LB3995_H)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Heat of Mixing and Solution of 2-Methylpropan-2-ol C4H10O + C8H18 Octane (HMSD1111, LB3995_H)' providing data from direct low-pressure calorimetric measurement of molar excess enthalpy at variable mole fraction and constant temperature.

  20. Volumetric Properties of the Mixture Cyclohexane C6H12 + C8H18O Dibutyl ether (VMSD1111, LB4006_V)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexane C6H12 + C8H18O Dibutyl ether (VMSD1111, LB4006_V)' providing data from direct low-pressure measurement of mass density at variable mole fraction and constant temperature, in the single-phase region(s).

  1. Volumetric Properties of the Mixture Cyclohexane C6H12 + C8H19N Dibutylamine (VMSD1212, LB3457_V)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexane C6H12 + C8H19N Dibutylamine (VMSD1212, LB3457_V)' providing data by calculation of molar excess volume from low-pressure density measurements at variable mole fraction and constant temperature.

  2. Volumetric Properties of the Mixture Cyclohexane C6H12 + C8H19N Dibutylamine (VMSD1111, LB3494_V)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexane C6H12 + C8H19N Dibutylamine (VMSD1111, LB3494_V)' providing data from direct low-pressure measurement of mass density at variable mole fraction and constant temperature, in the single-phase region(s).

  3. Volumetric Properties of the Mixture Cyclohexane C6H12 + C8H18O Dibutyl ether (VMSD1212, LB4004_V)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexane C6H12 + C8H18O Dibutyl ether (VMSD1212, LB4004_V)' providing data by calculation of molar excess volume from low-pressure density measurements at variable mole fraction and constant temperature.

  4. Volumetric Properties of the Mixture Cyclohexane C6H12 + C8H10 1,3-Dimethylbenzene (VMSD1111, LB3592_V)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexane C6H12 + C8H10 1,3-Dimethylbenzene (VMSD1111, LB3592_V)' providing data from direct low-pressure measurement of mass density at variable mole fraction and constant temperature, in the single-phase region(s).

  5. Volumetric Properties of the Mixture Hex-1-ene C6H12 + C8H10 1,2-Dimethylbenzene (VMSD1212, LB4577_V)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Hex-1-ene C6H12 + C8H10 1,2-Dimethylbenzene (VMSD1212, LB4577_V)' providing data by calculation of molar excess volume from low-pressure density measurements at variable mole fraction and constant temperature.

  6. Volumetric Properties of the Mixture Hex-1-ene C6H12 + C8H10 1,2-Dimethylbenzene (VMSD1111, LB5004_V)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Hex-1-ene C6H12 + C8H10 1,2-Dimethylbenzene (VMSD1111, LB5004_V)' providing data from direct low-pressure measurement of mass density at variable mole fraction and constant temperature, in the single-phase region(s).

  7. Volumetric Properties of the Mixture Cyclohexane C6H12 + C8H10 1,3-Dimethylbenzene (VMSD1212, LB3593_V)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexane C6H12 + C8H10 1,3-Dimethylbenzene (VMSD1212, LB3593_V)' providing data by calculation of molar excess volume from low-pressure density measurements at variable mole fraction and constant temperature.

  8. Heat of Mixing and Solution of Cyclohexane C6H12 + C8H10 1,4-Dimethylbenzene (HMSD1111, LB3677_H)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Heat of Mixing and Solution of Cyclohexane C6H12 + C8H10 1,4-Dimethylbenzene (HMSD1111, LB3677_H)' providing data from direct low-pressure calorimetric measurement of molar excess enthalpy at variable mole fraction and constant temperature.

  9. MEDIACRACY TURNS INTO A SYNONYM OF MEDIOCRITY?

    Directory of Open Access Journals (Sweden)

    Valentina CHIPER

    2014-11-01

    Full Text Available The link between freedom of speech and democracy is based on ideological legitimacy report. A new phenomenon which is worth noticing is the conversion of the freedom of expression from a freedom seen in certain aspects as a solitary freedom into a communication of the masses. Another challenge is prompted by the change of the traditional communication system at the dawn of technology, Internet and its various applications, as well as of the channels used. A weak point is the change in the values scale. If a journalist or a book is deemed good or valuable in terms of competence and ideas, these values are now unfortunately inspired by what we watch on TV. In this train of thoughts, reliable opinion leaders are no longer the same. Mediacracy turns into a synonym of mediocrity with affectivity and emotion prevailing over reason and instead of the communication of thoughts and opinions.

  10. Turned Back: Mad Men as Intermedial Melodrama

    Directory of Open Access Journals (Sweden)

    Monique Rooney

    2012-09-01

    Full Text Available This essay draws on definitions of gesture (Giorgio Agamben and Peter Brooks and catachresis (Peter Brooks, Jacques Derrida to examine the primacy of non-verbal signifiers as communicators of meaning in AMC’s Mad Men. Beginning with an analysis of Mad Men’s credit sequence, it draws attention to Mad Men’s use of gesture and catachresis in relation to melodrama’s privileging of non-verbal and naturalistic expression and its persistence as an intermedial mode that has moved back and forth between various media (theatre, novel, cinema, television and now digital formats. It argues that Mad Men’s melodramatic aesthetic is one that obliquely, and via a gestural and rhetorical ‘turned back’, communicates its relation to the past and the present.

  11. Turning Video Resource Management into Cloud Computing

    Directory of Open Access Journals (Sweden)

    Weili Kou

    2016-07-01

    Full Text Available Big data makes cloud computing more and more popular in various fields. Video resources are very useful and important to education, security monitoring, and so on. However, issues of their huge volumes, complex data types, inefficient processing performance, weak security, and long times for loading pose challenges in video resource management. The Hadoop Distributed File System (HDFS is an open-source framework, which can provide cloud-based platforms and presents an opportunity for solving these problems. This paper presents video resource management architecture based on HDFS to provide a uniform framework and a five-layer model for standardizing the current various algorithms and applications. The architecture, basic model, and key algorithms are designed for turning video resources into a cloud computing environment. The design was tested by establishing a simulation system prototype.

  12. Turning assistive machines into assistive robots

    Science.gov (United States)

    Argall, Brenna D.

    2015-01-01

    For decades, the potential for automation in particular, in the form of smart wheelchairs to aid those with motor, or cognitive, impairments has been recognized. It is a paradox that often the more severe a person's motor impairment, the more challenging it is for them to operate the very assistive machines which might enhance their quality of life. A primary aim of my lab is to address this confound by incorporating robotics autonomy and intelligence into assistive machines turning the machine into a kind of robot, and offloading some of the control burden from the user. Robots already synthetically sense, act in and reason about the world, and these technologies can be leveraged to help bridge the gap left by sensory, motor or cognitive impairments in the users of assistive machines. This paper overviews some of the ongoing projects in my lab, which strives to advance human ability through robotics autonomy.

  13. Introduction: The Participatory Turn in Urbanism

    Directory of Open Access Journals (Sweden)

    Maroš Krivý

    2014-08-01

    Full Text Available This issue of Footprint examines the recent participatory turn in urban planning and urban design. It discusses the co-opting of participatory processes by planning departments, the systematic disregard of inequalities, and the empowering of the market resulting from the ‘anti-statism’ present in many participatory schemes.What is the relationship between the institutionalisation of participation and the practices of autonomy, self-organisation, and inclusion? When and how does genuine empowerment of collectives take place? Does the demand for the empowerment of local organisations and communities strengthen the market forces at the expense of central government?This issue attempts to problematise ‘participation’, to call attentions to some of its shortcomings, deficits, and limitations, not in order to necessarily bypass the demand for the democratisation of the urban, but in order to rectify and strengthen it.

  14. Restricted access magnetic core-mesoporous shell microspheres with C8-modified interior pore walls for the identification of 20(S)-protopanaxadiol metabolites in rat plasma using UPLC-Q-TOF-MS/MS.

    Science.gov (United States)

    Ling, Jin; Yu, Yingjia; Feng, Jianan; Xu, Changjiang; Jiang, Jiebing; Wang, Liping; Long, Jiakun; Li, Yan; Duan, Gengli

    2017-06-01

    In the present study, a novel sample preparation method based on magnetic core-mesoporous shell microspheres with C8-modified interior pore walls (C8-Fe3O4@mSiO2) was established for the identification of 20(S)-protopanaxadiol (PPD) metabolites in rat plasma by UPLC-Q-TOF-MS/MS analysis. C8-Fe3O4@mSiO2 allowed selective extraction of PPD metabolites from rat plasma by excluding macromolecules in the plasma owing to size exclusion effect. Five extraction conditions including the amount of C8-Fe3O4@mSiO2 microspheres used, extraction time, elution solvents, elution volume, and elution time were investigated and optimized. The present method was compared with two conventional sample preparation methods: protein precipitation and C8 solid phase extraction (C8-SPE). Our method provided higher UPLC intensity of result than protein precipitation method. While the resulting intensity of our method and that of C8-SPE were not significantly different, it consumed less processing time (15min 55s for C8-Fe3O4@mSiO2, and 27min 30s for C8-SPE). Finally, the proposed method was successfully applied in the identification of PPD metabolites in vivo, in which a total of 17 metabolites and the parent drug were identified in rat plasma. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. Turn me on! Using the “Internet of Things” to turn things on and off

    CSIR Research Space (South Africa)

    Butgereit, L

    2011-10-01

    Full Text Available to the Internet. There are many examples of things posting their status on Twitter and allowing uni-directional access. TurnMeOn is an example of allowing bidirectional access between people and things using Internet protocols. Users can query the status of a...

  16. Why Critical Literacy Should Turn to "The Affective Turn": Making a Case for Critical Affective Literacy

    Science.gov (United States)

    Anwaruddin, Sardar M.

    2016-01-01

    The central argument of this essay is that critical literacy with a rationalistic bent may not enable us to cope with ethical dilemmas in our responsiveness to human sufferings. I argue that critical literacy education would benefit from turning to the recent scholarship on affect/emotion studies. I draw upon the works of Sara Ahmed--one of the…

  17. Assessing lexical, syntactic, and conceptual turn-by-turn alignment in conversations involving conflict and deception

    DEFF Research Database (Denmark)

    Duran, Nicholas; Fusaroli, Riccardo; Paxton, Alexandra

    2015-01-01

    -based NLP tools, the procedure begins by taking conversational partners' turns and converting each into a lemmatized sequence of words, assigning part-of-speech tags and computing high-dimensional semantic vectors per each utterance. Words and part-of-speech tags are further sequenced into n-g! rams...

  18. Now, It's Your Turn: How You Can Take Medicine Safely

    Science.gov (United States)

    ... turn Javascript on. Feature: Taking Medicines Safely Now, It's Your Turn: How You Can Take Medicine Safely ... medicine. The pharmacist has filled the prescription. Now it's up to you to take the medicine safely. ...

  19. Turning Gravitationally Lensed Supernovae into Cosmological Probes

    Science.gov (United States)

    Roberts-Pierel, Justin

    2017-08-01

    Recent HST observations have been critically important for twolandmark discoveries of gravitationally lensed supernovae: the firstmultiply-imaged SN, Refsdal, and the first Type Ia SN resolved intomultiple images, SN iPTF16geu. Fitting the multiple light curves ofsuch objects can deliver measurements of the lensing time delays,which in turn provide precise tests of lens models or uniqueconstraints on the Hubble constant and other cosmological parameters.For both of these SNe, initial constraints on the time delays havebeen limited by the need to account for subtle microlensingeffects. We will perform a complete reanalysis of both SN Refsdal andSN iPTF16geu, in order to refine estimates of their lensingmagnifications and time delays. Our work will improve upon previousefforts by revising the data processing and photometry, and includingthe significant yet previously ignored effects ofmicrolensing. Additionally, we will develop a publicly availablesoftware package in the course of this work, optimized specificallyfor multiply-imaged SNe. This software will be an important tool inthe next decade, supporting precise time delay measurements of tens tohundreds of lensed SNe to be found with LSST and WFIRST.

  20. Cosmopolitan Pluralism: Beyond the Cultural Turn

    Directory of Open Access Journals (Sweden)

    Stephanie Lawson

    2011-11-01

    Full Text Available The ‘cultural turn’ has had a profound influence across the humanities and social sciences in the last few decades. In calling into question the universalist basis on which conventional methodological and normative assumptions have been based, the cultural turn has focused on the extent to which specificity and particularity underpin what we can know, how we can know it, and how this affects our being-in-the world. This has opened the way to a range of insights, from issues of pluralism and difference, both within political communities and between them, to the instability if not impossibility of foundations for knowledge. Too few studies embracing this ‘cultural turn’, however, pay more than cursory attention to the culture concept itself. This article suggests that conceptions of culture derived mainly from the discipline of anthropology dominate in political studies, including international relations, while humanist conceptions have been largely ignored or rejected. It argues further that we would do well to reconsider what humanist ideas can contribute to how ‘culture’ is both conceptualized and deployed in political thought and action, especially in countering the overparticularization of social and political phenomena that marks contemporary culturalist approaches.

  1. IMPLEMENTATION PRINCIPLES – TURNING INTENTIONS INTO OUTCOMES

    Directory of Open Access Journals (Sweden)

    N. Faull

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: Companies sometimes fail to take effective action even when they know what they should do. Recent research shows that this surprising situation is more common than one would expect. How can the track record of companies in achieving the outcomes targeted by manufacturing strategy be improved? This article proposes a set of eight principles to improve the chances of taking effective action to turn intentions into outcomes. Rooted in the literature, the principles have also surfaced in case based research and commented on in the context of international consulting activities.

    AFRIKAANSE OPSOMMING: Dit gebeur partykeer dat maatskappye nie doelgerig optree nie, ook al weet hulle wat hulle moet doen. Onlangse navorsing dui aan dat so 'n verrassende situasie meer algemeen is as wat mens sou verwag. Hoe kan die baanrekord van maatskapye verbeter word om doelwitte wat in bedryfsstrategie gestel word werklik te beryk? Hierdie artikel stel ‚n reeks van agt beginsels voor om die kans dat effektiewe aksie geneem word om wense in uitslae te omskep, te verbeter. Die beginsels, gewortel in die literatuur, het ook in gevallestudie-gebaseerde navorsing ter sprake gekom en word hier bespreek in die konteks van internasionale raadgewende werk.

  2. Synthesis and Structure of [DB24C8)Na][Cd(SCN)3. Formation of a novel linear Cd...Cd...Cd chain with a mer-CdN3S3 coordination confirmation and new coiled [(DB24C8)Na]+ cation.

    Science.gov (United States)

    Zhang, H; Wang, X; Zelmon, D E; Teo, B K

    2001-03-26

    We report herein a novel coordination solid, [(DB24C8)Na][Cd(SCN)3] (6) (DB24C8 denotes dibenzo-24-crown-8), which exhibits a new type of [Cd(SCN)3-]infinity chain with two unusual stereochemical characteristics: (1) a mer-CdN3S3 coordination and (2) a linear Cd chain with a Cd...Cd...Cd angle of 180 degrees. In addition, the [(DB24C8)Na]+ monocation adopts a new structural type-a coiled structure-for the combination of crown ether DB24C8 and alkali metal Na+. The title compound crystallizes in a monoclinic unit cell of C2/c space group symmetry with lattice parameters a = 16.110(8) A, b = 20.380(5) A, c = 11.01(1) A, beta = 119.87(3) degrees, and Z = 4. The arrangement of the [Cd(SCN)3-](infinity) chains in the crystal lattice in the title compound is approximately hexagonal, creating triangular channels which are filled with [(DB24C8)Na]+ monocations. It was previously reasoned by us that the coiled [(DB24C8)Na]+ monocation, which lacks inversion or mirror symmetries, should enhance the tendency for the formation of the noncentrosymmetric space group of the title crystal, making it a potential second-order nonlinear optical crystal. Interestingly, however, the title compound crystallizes in a centrosymmetric space group (C2/c) and gives rise to no second harmonic generation (SHG). Previously known [Cd(SCN)3-](infinity) chains adopt fac-CdN3S3 coordination and a zigzag Cd chain configuration with a Cd...Cd...Cd angle of 165 degrees. The zigzag chains can align in either parallel or antiparallel fashion, resulting in efficient or no SHG effects, respectively. The linear Cd.Cd.Cd chain configuration observed in the title compound, on the other hand, makes it indistinguishable between parallel and antiparallel alignments. It is concluded that, to ensure the formation of noncentrosymmetric space groups, it is necessary to employ optically pure chiral cations as spacers and/or controllers. Furthermore, to enhance the nonlinear optical responses, [Cd(SCN)3-]infinity

  3. History of Education in Canada: Historiographic "Turns" and Widening Horizons

    Science.gov (United States)

    Bruno-Jofré, Rosa

    2014-01-01

    This paper explores major historiographic "turns" in history of education with a focus, although not exclusively, on English-speaking Canada. It addresses the transformative intellectual impact of the turn toward social history on the history of education, the impact of cultural history and the linguistic turn, the reception of Michel…

  4. Turn Openings in Academic Talk: Where Goals and Roles Intersect

    Science.gov (United States)

    Evison, Jane

    2013-01-01

    This study uses Corpus Linguistic (CL) techniques to explore multiple turn openings in conjunction with comparative measures of turn-initial priming (the proportion of occurrences of a form that are turn-initial). Using a benchmark corpus of casual conversation as a point of comparison, six frequent items which have a particularly strong affinity…

  5. 33 CFR 164.42 - Rate of turn indicator.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Rate of turn indicator. 164.42...) PORTS AND WATERWAYS SAFETY NAVIGATION SAFETY REGULATIONS § 164.42 Rate of turn indicator. Each vessel of... turn indicator. ...

  6. Tomographic reconstruction of transverse phase space from turn-by-turn profile data

    CERN Document Server

    Hancock, S; Lindroos, M

    1999-01-01

    Tomographic methods have the potential for useful application in beam diagnostics. The tomographic reconstruction of transverse phase space density from turn-by-turn profile data has been studied with particular attention to the effects of dispersion and chromaticity. It is shown that the modified Algebraic Reconstruction Technique (ART) that deals successfully with the problem of non-linear motion in the longitudinal plane cannot, in general, be extended to cover the transverse case. Instead, an approach is proposed in which the effect of dispersion is deconvoluted from the measured profiles before the phase space picture is reconstructed using either the modified ART algorithm or the inverse Radon Transform. This requires an accurate knowledge of the momentum distribution of the beam and the modified ART reconstruction of longitudinal phase space density yields just such information. The method has been tested extensively with simulated data.

  7. Model-independent analysis of the Fermilab Tevatron turn-by-turn beam position monitor measurements

    Energy Technology Data Exchange (ETDEWEB)

    Petrenko, A.V.; /Novosibirsk, IYF; Valishev, A.A.; Lebedev, V.A.; /Fermilab

    2011-09-01

    Coherent transverse beam oscillations in the Tevatron were analyzed with the model-independent analysis (MIA) technique. This allowed one to obtain the model-independent values of coupled betatron amplitudes, phase advances, and dispersion function around the ring from a single dipole kick measurement. In order to solve the MIA mode mixing problem which limits the accuracy of determination of the optical functions, we have developed a new technique of rotational MIA mode untangling. The basic idea is to treat each beam position monitor (BPM) as two BPMs separated in a ring by exactly one turn. This leads to a simple criterion of MIA mode separation: the betatron phase advance between any BPM and its counterpart shifted by one turn should be equal to the betatron tune and therefore should not depend on the BPM position in the ring. Furthermore, we describe a MIA-based technique to locate vibrating magnets in a storage ring.

  8. Turned On / Turned Off: Speculating on the Microchip-based Contraceptive Implant

    DEFF Research Database (Denmark)

    Homewood, Sarah; Heyer, Clint

    2017-01-01

    For over 50 years, hormone-based contraceptives have allowed women to control their fertility, thus reconfiguring society and how women relate to their body. On the horizon are long-life microchip-based implanted contraceptives that can be turned on and off, which may further the societal...... discussions around security, relationships and hormones. Drawing from the outcomes of the workshop, we produce a speculative design in the form of a film and physical mock-ups....

  9. Synthesis of the northern sector (C8-C19) of rapamycin via Chan rearrangement and oxidation of an α-acyloxyacetate

    Science.gov (United States)

    Jeffrey, Scott C.

    2009-01-01

    Two routes to the masked tricarbonyl segment of the immunosuppressant rapamycin comprising C8-C19 were explored beginning from D-xylose. The first approach employed a protected form of 2,4,5-trihydroxypentanol to obtain dithiane 43, which failed to react with dimethyl oxalate to give a 1,2,3-tricarbonyl unit corresponding to the northern sector of rapamycin. A second approach employing carboxylic acid 61 derived from 43 utilized base-mediated (Chan) rearrangement of α-acyloxyacetate 62 with trapping of the resultant enediolate as bis silyl ether 63. Epoxidation of this diene afforded masked tri-keto ester 65 which underwent acid-catalyzed methanolysis to produce cyclic ketal 67. PMID:20161171

  10. CINÉTICA DE CRAQUEAMENTO DE HIDROCARBONETOS (C8) UTILIZANDO MICROPIRÓLISE EM TUBO DE VIDRO SELADO APLICAÇÃO EM MODELAGEM GEOQUÍMICA

    OpenAIRE

    Regina Binotto

    2010-01-01

    Um dos problemas fundamentais em modelagem de sistemas petrolíferos relacionado à Exploração de Petróleo é estimar os limites de tempo e extensão da geração de petróleo em bacias sedimentares. O objetivo deste trabalho é medir os parâmetros cinéticos de craqueamento das frações mais leves do óleo (C8) para gás, visando identificar as condições geológicas extremas para sua preservação. Para isso foi desenvolvido um método utilizando a micropirólise em tubo de vidro selado, MSSV ...

  11. Observation of ZnO nanoparticles outside pores of nano Zn 4O(C 8H 4O 4) 3 metal-organic framework

    Science.gov (United States)

    Zhang, Lei; Hu, Yun Hang

    2011-03-01

    It was recognized that ZnO can be formed during synthesizing nano Zn 4O(C 8H 4O 4) 3 metal-organic framework (nano MOF-5). Furthermore, it is generally accepted that the ZnO is dispersed inside the pores of MOF-5. However, herein, the measurements of X-ray powder diffraction (XRD) and transmission electron microscopy (TEM) showed that the crystal particle sizes of ZnO in MOF-5 are in the range of 5-18 nm, which are larger than the pore size of MOF-5 (1.3 nm). This clearly demonstrates that those ZnO nanoparticles are located outside the pores of MOF-5.

  12. Carrier recombination spatial transfer by reduced potential barrier causes blue/red switchable luminescence in C8 carbon quantum dots/organic hybrid light-emitting devices

    Directory of Open Access Journals (Sweden)

    Xifang Chen

    2016-04-01

    Full Text Available The underlying mechanism behind the blue/red color-switchable luminescence in the C8 carbon quantum dots (CQDs/organic hybrid light-emitting devices (LEDs is investigated. The study shows that the increasing bias alters the energy-level spatial distribution and reduces the carrier potential barrier at the CQDs/organic layer interface, resulting in transition of the carrier transport mechanism from quantum tunneling to direct injection. This causes spatial shift of carrier recombination from the organic layer to the CQDs layer with resultant transition of electroluminescence from blue to red. By contrast, the pure CQDs-based LED exhibits green–red electroluminescence stemming from recombination of injected carriers in the CQDs.

  13. Synthesis and structure-activity relationship study of FD-891: importance of the side chain and C8-C9 epoxide for cytotoxic activity against cancer cells.

    Science.gov (United States)

    Itagaki, Tomohiro; Kawamata, Ayano; Takeuchi, Miho; Hamada, Keisuke; Iwabuchi, Yoshiharu; Eguchi, Tadashi; Kudo, Fumitaka; Usui, Takeo; Kanoh, Naoki

    2016-04-01

    Unified synthesis of FD-891 analogs and their structure-activity relationship are described. By using stereoselective allylation/crotylation and Evans aldol chemistry, six side-chain fragments having different length and terminus were synthesized. These fragments were coupled with a macrolactone fragment, improved synthesis of which was also developed here, to generate FD-891 and five truncated analogs. These synthetic compounds as well as three analogs obtained from fermentation of gene-disrupted Streptomyces graminofaciens mutants were tested for in vitro cytotoxic activity against HeLa cells. As a result, coexistence of the C8-C9 epoxide and side-chain terminus was found to be critical for the cytotoxic activity.

  14. Three-dimensional topographic index applied to the prediction of acyclic C5-C8 alkenes Kováts retention indices on polydimethylsiloxane and squalane columns.

    Science.gov (United States)

    Ren, Yueying; Liu, Huanxiang; Yao, Xiaojun; Liu, Mancang

    2007-06-29

    A novel approach is described for the prediction of gas chromatographic Kováts retention indices of 150 acyclic C5-C8 alkenes on two stationary phases (polydimethylsiloxane, PDMS, and squalane, SQ). The heuristic method was used to build multiple linear regression models using descriptors calculated by MODLESLAB software and CODESSA program. The resulting quantitative structure-retention relationship (QSRR) models were well-correlated, with predictive R2 values of 0.970 and 0.958 for retention indices on PDMS and SQ columns, respectively. 1Omegap, a three-dimensional (3D) topographic index, was found to play the most important role in the description of the chromatographic retention behavior of the alkenes in these two stationary phases. Moreover, this index could completely distinguish different isomers of alkene. Therefore, it can also be extended to distinguish different isomers of other compounds so that can well describe their quantitative structure-retention relationships.

  15. Turn-Based War Chess Model and Its Search Algorithm per Turn

    Directory of Open Access Journals (Sweden)

    Hai Nan

    2016-01-01

    Full Text Available War chess gaming has so far received insufficient attention but is a significant component of turn-based strategy games (TBS and is studied in this paper. First, a common game model is proposed through various existing war chess types. Based on the model, we propose a theory frame involving combinational optimization on the one hand and game tree search on the other hand. We also discuss a key problem, namely, that the number of the branching factors of each turn in the game tree is huge. Then, we propose two algorithms for searching in one turn to solve the problem: (1 enumeration by order; (2 enumeration by recursion. The main difference between these two is the permutation method used: the former uses the dictionary sequence method, while the latter uses the recursive permutation method. Finally, we prove that both of these algorithms are optimal, and we analyze the difference between their efficiencies. An important factor is the total time taken for the unit to expand until it achieves its reachable position. The factor, which is the total number of expansions that each unit makes in its reachable position, is set. The conclusion proposed is in terms of this factor: Enumeration by recursion is better than enumeration by order in all situations.

  16. Absolute bioavailability of evacetrapib in healthy subjects determined by simultaneous administration of oral evacetrapib and intravenous [13C8]‐evacetrapib as a tracer

    Science.gov (United States)

    Aburub, Aktham; Ward, Chris; Hinds, Chris; Czeskis, Boris; Ruterbories, Kenneth; Suico, Jeffrey G.; Royalty, Jane; Ortega, Demetrio; Pack, Brian W.; Begum, Syeda L.; Annes, William F.; Lin, Qun; Small, David S.

    2015-01-01

    This open‐label, single‐period study in healthy subjects estimated evacetrapib absolute bioavailability following simultaneous administration of a 130‐mg evacetrapib oral dose and 4‐h intravenous (IV) infusion of 175 µg [13C8]‐evacetrapib as a tracer. Plasma samples collected through 168 h were analyzed for evacetrapib and [13C8]‐evacetrapib using high‐performance liquid chromatography/tandem mass spectrometry. Pharmacokinetic parameter estimates following oral and IV doses, including area under the concentration‐time curve (AUC) from zero to infinity (AUC[0‐∞]) and to the last measureable concentration (AUC[0‐tlast]), were calculated. Bioavailability was calculated as the ratio of least‐squares geometric mean of dose‐normalized AUC (oral : IV) and corresponding 90% confidence interval (CI). Bioavailability of evacetrapib was 44.8% (90% CI: 42.2–47.6%) for AUC(0‐∞) and 44.3% (90% CI: 41.8–46.9%) for AUC(0‐tlast). Evacetrapib was well tolerated with no reports of clinically significant safety assessment findings. This is among the first studies to estimate absolute bioavailability using simultaneous administration of an unlabeled oral dose with a 13C‐labeled IV microdose tracer at about 1/1000th the oral dose, with measurement in the pg/mL range. This approach is beneficial for poorly soluble drugs, does not require additional toxicology studies, does not change oral dose pharmacokinetics, and ultimately gives researchers another tool to evaluate absolute bioavailability. PMID:26639670

  17. Effectiveness of Higher Fatty Acids C8, C10 and C12, Dimethyl Dicarbonate and Sulphur Dioxide for Inhibition of Re-fermentation and Malolactic Activities in Wine

    Directory of Open Access Journals (Sweden)

    Mojmír Baroň

    2014-01-01

    Full Text Available The issue of preventing the re-fermentation and protection against undesirable malolactic fermentation (MLF in order to safe content of acids in wine is very complicated. In this paper the saturated higher fatty acids (HFA – C8, C10 and C12, dimethyldicarbonate (DMDC and sulphur dioxide (SO2 were tested. The re-fermentation test showed the strongest inhibition power at ratio 2:8, 1:9 and 0:10 as C8:C10 acids – 65 days without re-fermentation. MLF experiments confirmed that addition of SO2 into the fermenting media causes rapid inhibition of lactic acid bacteria metabolic activity. Malic acid concentrations were proportionally decreasing during 6 days of experiment and at the end the content of this acid varied between 0.16 and 0.22 g/L, the only exception formed a variant with the addition of SO2 (1.57 g/L of malic acid. After calculation of the average consumption rate of malic acid, the results showed the inhibition power – SO2 (81.05% followed by variant of 40 mg/L mixture of HFA (40.76%, a variant of 200 mg/L of DMDC (31.98% and a variant of 20 mg/L mixture of HFA (12.59%. The addition of HFA can significantly reduce the dosage of other preservatives, especially SO2. Based on results, this method can be recommend in the production of wines with residual sugar and also wines made from over-mature material to prevent undesirable MLF.

  18. Revisiting GNRA and UNCG folds: U-turns versus Z-turns in RNA hairpin loops.

    Science.gov (United States)

    D'Ascenzo, Luigi; Leonarski, Filip; Vicens, Quentin; Auffinger, Pascal

    2017-03-01

    When thinking about RNA three-dimensional structures, coming across GNRA and UNCG tetraloops is perceived as a boon since their folds have been extensively described. Nevertheless, analyzing loop conformations within RNA and RNP structures led us to uncover several instances of GNRA and UNCG loops that do not fold as expected. We noticed that when a GNRA does not assume its "natural" fold, it adopts the one we typically associate with a UNCG sequence. The same folding interconversion may occur for loops with UNCG sequences, for instance within tRNA anticodon loops. Hence, we show that some structured tetranucleotide sequences starting with G or U can adopt either of these folds. The underlying structural basis that defines these two fold types is the mutually exclusive stacking of a backbone oxygen on either the first (in GNRA) or the last nucleobase (in UNCG), generating an oxygen-π contact. We thereby propose to refrain from using sequences to distinguish between loop conformations. Instead, we suggest using descriptors such as U-turn (for "GNRA-type" folds) and a newly described Z-turn (for "UNCG-type" folds). Because tetraloops adopt for the largest part only two (inter)convertible turns, we are better able to interpret from a structural perspective loop interchangeability occurring in ribosomes and viral RNA. In this respect, we propose a general view on the inclination for a given sequence to adopt (or not) a specific fold. We also suggest how long-noncoding RNAs may adopt discrete but transient structures, which are therefore hard to predict. © 2017 D'Ascenzo et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  19. Transparent lattice characterization with gated turn-by-turn data of diagnostic bunch train

    Science.gov (United States)

    Li, Yongjun; Cheng, Weixing; Ha, Kiman; Rainer, Robert

    2017-11-01

    Methods of characterization of a storage ring's lattice have traditionally been intrusive to routine operations. More importantly, the lattice seen by particles can drift with the beam current due to collective effects. To circumvent this, we have developed a novel approach for dynamically characterizing a storage ring's lattice that is transparent to operations. Our approach adopts a dedicated filling pattern which has a short, separate diagnostic bunch train (DBT). Through the use of a bunch-by-bunch feedback system, the DBT can be selectively excited on demand. Gated functionality of a beam position monitor system is capable of collecting turn-by-turn data of the DBT, from which the lattice can then be characterized after excitation. As the DBT comprises only about one percent of the total operational bunches, the effects of its excitation are negligible to users. This approach allows us to localize the distributed quadrupolar wakefields generated in the storage ring vacuum chamber during beam accumulation. While effectively transparent to operations, our approach enables us to dynamically control the beta beat and phase beat, and unobtrusively optimize performance of the National Synchrotron Light Source-II accelerator during routine operations.

  20. Transparent lattice characterization with gated turn-by-turn data of diagnostic bunch train

    Directory of Open Access Journals (Sweden)

    Yongjun Li

    2017-11-01

    Full Text Available Methods of characterization of a storage ring’s lattice have traditionally been intrusive to routine operations. More importantly, the lattice seen by particles can drift with the beam current due to collective effects. To circumvent this, we have developed a novel approach for dynamically characterizing a storage ring’s lattice that is transparent to operations. Our approach adopts a dedicated filling pattern which has a short, separate diagnostic bunch train (DBT. Through the use of a bunch-by-bunch feedback system, the DBT can be selectively excited on demand. Gated functionality of a beam position monitor system is capable of collecting turn-by-turn data of the DBT, from which the lattice can then be characterized after excitation. As the DBT comprises only about one percent of the total operational bunches, the effects of its excitation are negligible to users. This approach allows us to localize the distributed quadrupolar wakefields generated in the storage ring vacuum chamber during beam accumulation. While effectively transparent to operations, our approach enables us to dynamically control the beta beat and phase beat, and unobtrusively optimize performance of the National Synchrotron Light Source-II accelerator during routine operations.

  1. The turning point in the number of traffic fatalities

    DEFF Research Database (Denmark)

    Brüde, Ulf; Elvik, Rune

    2015-01-01

    The number of traffic fatalities reached a peak in many highly motorised countries around 1970. Some previous studies have suggested that the turning point in the number of traffic fatalities was inevitable and did not reflect a change in the underlying trends influencing the number of traffic...... fatalities. Other studies suggest that trends in traffic growth and fatality rate changed from before to after the turning point. This paper proposes two hypotheses about the turning point in the number of traffic fatalities. One hypothesis is that the long-term trends in traffic growth and fatality rate...... were the same before and after the turning point. The other hypothesis is that the long-term trends in traffic growth and fatality rate were different before and after the turning point was reached, in particular that the annual percentage decline in fatality rate became greater after the turning point...

  2. Analysis of a turning point problem in flight trajectory optimization

    Science.gov (United States)

    Gracey, C.

    1989-01-01

    The optimal control policy for the aeroglide portion of the minimum fuel, orbital plane change problem for maneuvering entry vehicles is reduced to the solution of a turning point problem for the bank angle control. For this problem a turning point occurs at the minimum altitude of the flight, when the flight path angle equals zero. The turning point separates the bank angle control into two outer solutions that are valid away from the turning point. In a neighborhood of the turning point, where the bank angle changes rapidly, an inner solution is developed and matched with the two outer solutions. An asymptotic analysis of the turning point problem is given, and an analytic example is provided to illustrate the construction of the bank angle control.

  3. Anticipation in turn-taking: mechanisms and information sources

    Directory of Open Access Journals (Sweden)

    Carina eRiest

    2015-02-01

    Full Text Available During conversations participants alternate smoothly between speaker and hearer roles with only brief pauses and overlaps. There are two competing types of accounts about how conversationalists accomplish this: (a the signalling approach and (b the anticipatory (‘projection’ approach. We wanted to investigate, first, the relative merits of these two accounts, and second, the relative contribution of semantic and syntactic information to the timing of next turn initiation. We performed three button-press experiments using turn fragments taken from natural conversations to address the following questions: (a Is turn-taking predominantly based on anticipation or on reaction, and (b what is the relative contribution of semantic and syntactic information to accurate turn-taking. In our first experiment we gradually manipulated the information available for anticipation of the turn end (providing information about the turn end in advance to completely removing linguistic information. The results of our first experiment show that the distribution of the participants’ estimation of turn-endings for natural turns is very similar to the distribution for pure anticipation. We conclude that listeners are indeed able to anticipate a turn-end and that this strategy is predominantly used in turn-taking. In Experiment 2 we collected purely reacted responses. We used the distributions from Experiments 1 and 2 together to estimate a new dependent variable called Reaction Anticipation Proportion (RAP. We used this variable in our third experiment where we manipulated the presence vs absence of semantic and syntactic information by low-pass filtering open-class and closed class words in the turn. The results suggest that for turn-end anticipation, both semantic and syntactic information are needed, but that the semantic information is a more important anticipation cue than syntactic information.

  4. Anticipation in turn-taking: mechanisms and information sources.

    Science.gov (United States)

    Riest, Carina; Jorschick, Annett B; de Ruiter, Jan P

    2015-01-01

    During conversations participants alternate smoothly between speaker and hearer roles with only brief pauses and overlaps. There are two competing types of accounts about how conversationalists accomplish this: (a) the signaling approach and (b) the anticipatory ('projection') approach. We wanted to investigate, first, the relative merits of these two accounts, and second, the relative contribution of semantic and syntactic information to the timing of next turn initiation. We performed three button-press experiments using turn fragments taken from natural conversations to address the following questions: (a) Is turn-taking predominantly based on anticipation or on reaction, and (b) what is the relative contribution of semantic and syntactic information to accurate turn-taking. In our first experiment we gradually manipulated the information available for anticipation of the turn end (providing information about the turn end in advance to completely removing linguistic information). The results of our first experiment show that the distribution of the participants' estimation of turn-endings for natural turns is very similar to the distribution for pure anticipation. We conclude that listeners are indeed able to anticipate a turn-end and that this strategy is predominantly used in turn-taking. In Experiment 2 we collected purely reacted responses. We used the distributions from Experiments 1 and 2 together to estimate a new dependent variable called Reaction Anticipation Proportion. We used this variable in our third experiment where we manipulated the presence vs. absence of semantic and syntactic information by low-pass filtering open-class and closed class words in the turn. The results suggest that for turn-end anticipation, both semantic and syntactic information are needed, but that the semantic information is a more important anticipation cue than syntactic information.

  5. Eye movements differ between ictal ipsilateral and contralateral head turning.

    Science.gov (United States)

    Baysal-Kirac, Leyla; Rémi, Jan; Loesch, Anna Mira; Hartl, Elisabeth; Vollmar, Christian; Noachtar, Soheyl

    2015-08-01

    This study evaluated the relation of head and eye movements during ictal ipsilateral and contralateral head turning in patients with focal epilepsies with regard to lateralization of the epileptogenic zone. We reviewed our database and identified patients with ictal head turning ipsilateral and contralateral to the seizure onset as defined by ictal EEG. Twenty-seven seizures of 19 consecutive patients with ipsilateral and 40 seizures of 32 patients with contralateral head turning were investigated. Twenty-four patients had temporal lobe epilepsy (TLE), and 27 patients had extratemporal or multifocal epilepsy. Eye movement in the same direction preceded contralateral head turning in 90% (36 of 40 seizures) of the seizures, but this was the case in only 33% (9 of 27 seizures) of the ipsilateral ictal head turning. In contrary, head turning preceded the eye movements in 67% (18 of 27 seizures) of the ipsilateral ictal head turning and in only 10% of the contralateral head turning (p eye movements is different in ictal ipsilateral and contralateral head turning movements which likely reflects different spread patterns of epileptic activity associated with activation of different generators. The analysis of eye movements adds to the lateralization of ictal head movements. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Injection Matching Studies using Turn by Turn Beam Profile Measurements in the CERN PS

    CERN Document Server

    Benedikt, Michael; Dutriat, C; Jansson, A; Giovannozzi, Massimo; Martini, M; Raich, U

    2001-01-01

    The very small emittance beam needed for the LHC requires that the emittance blow-up in its injector machines must be kept to a minimum. Mismatch upon the beam transfer from one machine to the next is a potential source of such blow-up. The CERN PS ring is equipped with 3 Secondary Emission Grids (SEM-Grids) which are used for emittance measurement at injection. One of these has been converted to a multi-turn mode, in which several tens of consecutive beam passages can be observed. This allows the study of mismatch between the PS-Booster and the PS. This paper describes the instrument and experimental results obtained during the last year.

  7. CONNECTION OF TURN AHEAD AND TURN BACK WITH MOTORIC ABILITIES OF THE FOURTH GRADE OF HIGH SCHOOL

    Directory of Open Access Journals (Sweden)

    Jovica Petković

    2008-08-01

    Full Text Available The research is done for the purpose of determination and defining of the level of connection between some motoric abilities with success in realization of programmed contents from the area of gymnastics (turn ahead and turn back. The research is done on the sample of fifty students from the fourth grade of High School, on ten motoric tests and on two specific motoric assignments – turn ahead and turn back. The results of this research clearly point that there exist the multitude of statistically important coefficients of correlation between treated motoric abilities and applied motoric assignments.

  8. X-Ray study of hetero ring flexibility in norbornane, norbornene-fused 1,3-oxazin-2-thiones Structure of 5,8-methano- r-4-phenyl-c-4a, c-5,6,7, c-8, c- 8a-hexahydro-4H- 1 ,3-benzoxazin-2 (3H)-thione

    Science.gov (United States)

    Kálmán, A.; Argay, Gy.; Stájer, G.; Bernáth, G.

    1991-08-01

    The structure of S,8-methano- r-4-phenyl c4a, c5,6,7 c8 c8ahexahydro4 H 1,3 -benzoxazin- 2 (3 H)-thione (C 15H 17N0S, M r=259.37) has been established by X-ray crystallography from diffractometer data: it crystallizes in the monoclinic space group P2 1/n with a=6.150(2) Å, b=9.655(1) Å, c=22.093(4) Å,β=96.75(2)† V=1302.7(8) Å 3,4,D c=1.32gcm -3and p( Cu K) =20.4cm -. The structure has been solved by direct methods, refined to R=0.050 for 2193 observed reflections. The X-ray analysis substantiated the structure: the NMR spectra in- dicated that the 4-phenyl group assumes an exo-equatorial position. The puckering parameters of D. Cremer, J.A. Pople, J. Am. Chem. Soc., 97 (1975), 1354 (ref.1), of the distorted hetero ring (a transitional form between E 4-envelope, ( 5S 4-screw-boat) show that, depending on the positions of the hetero atoms, both the norbornane, norbornene skeletons markedly alter the characteristic transitional ( 5E/ 5H 6) shape of the 1,3-oxazine ring observed in other saturated, partly saturated l,3-benzoxazin-2-ones, analogous thiones.

  9. The evolution of cooperative turn-taking in animal conflict

    NARCIS (Netherlands)

    Franz, Mathias; van der Post, Daniel; Schuelke, Oliver; Ostner, Julia

    2011-01-01

    Background: A fundamental assumption in animal socio-ecology is that animals compete over limited resources. This view has been challenged by the finding that individuals might cooperatively partition resources by " taking turns". Turn-taking occurs when two individuals coordinate their agonistic

  10. Quasi-Automatic Monitoring System For Turning Operation Using ...

    African Journals Online (AJOL)

    This work discusses the generation of a quasi monitoring system intended for an operator to change cutting tool during turning operation. The monitoring system uses the effects of turning va riables on acoustic emission signal responses and factorial experimental design approach. In cutting operations, acoustic emission ...

  11. Experimentation and Prediction of Temperature Rise in Turning ...

    African Journals Online (AJOL)

    Experimentation and Prediction of Temperature Rise in Turning Process using Response Surface Methodology. ... Reducing the temperature rise during turning operation improves the quality of the product and reduces tool wear. Experiments are conducted as per the Design of Experiments (DoE) of Response Surface ...

  12. Density of Plutonium Turnings Generated from Machining Activities

    Energy Technology Data Exchange (ETDEWEB)

    Gonzales, John Robert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Vigil, Duane M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Jachimowski, Thomas A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Archuleta, Alonso [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Arellano, Gerald Joseph [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Melton, Vince Lee [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-10-20

    The purpose of this project was to determine the density of plutonium (Pu) turnings generated from the range of machining activities, using both surrogate material and machined Pu turnings. Verify that 500 grams (g) of plutonium will fit in a one quart container using a surrogate equivalent volume and that 100 grams of Pu will fit in a one quart Savy container.

  13. Performance Characteristics of a Cam Turning Attachment | Tuleun ...

    African Journals Online (AJOL)

    A modification of a cylindrical turning unit has been done to give a non-cylindrical turning attachment for production of irregular shapes, like cams on the lathe machine. To assess the performance of the attachment, cutting forces have been measured using a 'Sigma' Cutting Tool Dynamometer. Furthermore, the effect of ...

  14. Fast Turn-off Mine Transient Electromagnetic Transmitter System

    Directory of Open Access Journals (Sweden)

    ZHENG Xiao-Liang

    2014-05-01

    Full Text Available For solving problems such as short turn-off time, high linear degree of falling edge, measurement of turn-off time and influence of primary signals for transient electromagnetic transmitter, and restrictions because of the environmental conditions of underground coal mine, this thesis aims at designing a new transient electromagnetic transmitter system suitable for coal mine. Supported by damping absorption circuit, such system applies small volume, sectional transmitting coil, with features of short turn-off time, high linear degree of current falling edge. It uses the transmitter monitoring circuit, which accurately measures turn-off time and simultaneously records the current value changes after turn-off, thus to eliminate the influence of primary field as well as to restore earlier secondary field signals for reference and finally to improve the ability to detect the shallow structure. It turns out that the new system has a shorter turn-off time, a higher linear degree of current falling and more accurate data record of turn-off current.

  15. Optimizing feed force for turned parts through the Taguchi technique

    Indian Academy of Sciences (India)

    Abstract. The objective of the paper is to obtain an optimal setting of turning process parameters (cutting speed, feed rate and depth of cut) resulting in an optimal value of the feed force when machining EN24 steel with TiC-coated tungsten- carbide inserts. The effects of the selected turning process parameters on feed force.

  16. Human Rights Education and the Post Secular Turn

    Science.gov (United States)

    Bowie, Bob

    2012-01-01

    This article questions whether human rights education (HRE) scholarship is responding adequately to the post secular turn in thinking about the place and nature of religion in society. Here the post secular turn is used to describe the discrediting of secularisation theory, the recognition of religion as an enduring and pervasive global cultural…

  17. Cutting forces during turning with variable depth of cut

    Directory of Open Access Journals (Sweden)

    M. Sadílek

    2016-03-01

    The proposed research for the paper is an experimental work – measuring cutting forces and monitoring of the tool wear on the cutting edge. It compares the turning where standard roughing cycle is used and the turning where the proposed roughing cycle with variable depth of cut is applied.

  18. Seasonal contributions to size-resolved n-alkanes (C8-C40) in the Shanghai atmosphere from regional anthropogenic activities and terrestrial plant waxes.

    Science.gov (United States)

    Lyu, Yan; Xu, Tingting; Yang, Xin; Chen, Jianmin; Cheng, Tiantao; Li, Xiang

    2017-02-01

    Size-resolved aerosol samples from the Shanghai atmosphere were analyzed for normal alkanes (n-alkanes, C8-C40) by comprehensive two-dimensional gas chromatography-flame ionization detection and gas chromatography-triple quadruple mass spectroscopy to study their size distribution and contributions from potential regional sources based on a one-year (2012-2013) sampling campaign. The n-alkane concentrations ranged from 62.3 to 398.5ngm-3, with an annual average of 227.6ngm-3. Particle-associated n-alkanes exhibited a bimodal distribution with one peak in the accumulation-mode size range and the other in the coarse-mode size range. As the carbon number increased, the peak in the accumulation mode intensified and the peak in the coarse mode weakened, in accordance with variation of their corresponding volatilities. Source indices (carbon preference index, average chain length, odd-even carbon number preference, unresolved to resolved n-alkanes ratio, and plant wax n-alkanes ratio) indicated that the n-alkane source profile shifted from an anthropogenic-dominated pattern in winter and spring to a terrestrial plant wax-influenced pattern in summer and autumn. Further trajectory cluster analysis and potential source contribution function modeling showed that anthropogenic activities were mainly in the North China Plain and East China and that terrestrial plant waxes originated in Anhui, Zhejiang, and Jiangxi Provinces. The results of our study provide useful information for evaluating the influence of anthropogenic and biogenic activities on the atmospheric transport of important secondary organic aerosol precursors to megacities in East Asia. Copyright © 2016. Published by Elsevier B.V.

  19. Alternate Reductants with VB12 to Transform C8 and C6 Perfluoroalkyl Sulfonates: Limitations and Insights into Isomer-Specific Transformation Rates, Products and Pathways.

    Science.gov (United States)

    Park, Saerom; de Perre, Chloe; Lee, Linda S

    2017-12-05

    Previous studies evaluating Vitamin B12 (VB12) with Ti(III)-citrate for potential use in in situ remediation of perfluorooctanesulfonate (PFOS) found that linear (L)-PFOS was unaltered. We explored if alternate reductants could overcome this limitation with a primary focus on nanoscale zerovalent zinc (nZn 0 ). Transformation over time with VB12-nZn 0 was quantified at 22, 70, and 90 °C for PFOS, at 70 °C for perfluorohexanesulfonate (PFHxS), and VB12-nFe 0 and VB12-Pd 0 /nFe 0 at 70 °C for PFOS. Only branched (br-) isomers were transformed generating F - (no SO 4 2- ) and polyfluoroalkyl intermediates/products. The absence of L-PFOS transformation by VB12 appears to be due to the inability of L-perfluoroalkyl sulfonates to complex with VB12 and not an activation energy issue that can be overcome by stronger reductants/catalysts. At 90 °C, 95% of br-PFOS isomers were transformed within 5 days. Isomer-specific removal rates were positively correlated to the br-CF 3 's proximity to the terminal CF 3 . Br-PFHxS transformation was approximately two times slower with less defluorination than br-PFOS. C8/C7 and C6/C5 polyfluorinated sulfonates from br-PFOS and br-PFHxS, respectively, were identified as both intermediates and apparent dead-end products. Pathways included 4 F replaced by 2 H and a C═C bond, and serial F replacement by H with up to 12 F atoms removed from br-PFOS.

  20. Translesion synthesis past guanine(C8)-thymine(N3) intrastrand cross-links catalyzed by selected A- and Y-family polymerases.

    Science.gov (United States)

    Lee, Young-Ae; Lee, Yuan-Cho; Geacintov, Nicholas E; Shafirovich, Vladimir

    2016-05-24

    Oxidatively generated guanine radicals in DNA can undergo various nucleophilic reactions including the formation of C8-guanine cross-links with adjacent or nearby N3-thymines in DNA in the presence of O2. These G[8-3]T lesions have been identified in the DNA of human cells exposed to oxidative stress, and are most likely genotoxic if not removed by cellular defence mechanisms. The abilities of several representative polymerases to bypass the G[8-3]T lesions in two different sequence contexts, G*T* and G*CT*, were assessed in vitro. The polymerase BF (bacillus fragment) from Bacillus stearothermophilus, the Y-family archaeal polymerases Dpo4 from Sulfolobus sulfataricus P2, and human DNA pol κ and pol η were selected for the study. The A-family polymerase BF was strongly blocked, while relatively weak translesion synthesis was observed in the case of Y-family polymerases Dpo4 and pol κ. Primer extension catalyzed by pol η was also partially stalled at various positions at or near the G[8-3]T cross-linked bases, but a significant and distributive primer extension was observed beyond the sites of the lesions with the efficiency being consistently greater in the case of G*CT* than in the case of G*T* lesions. The results obtained with pol η are compared with translesion synthesis past other intrastrand cross-linked lesions with previously published results of others that include the isomeric G[8-5m]T lesions generated by ionizing radiation, the cis-syn cyclobutane pyrimidine dimer and the 6-4 photoproduct generated by UV irradiation, and the Pt-G*G* lesions derived from the reactions of the chemotherapeutic agent cisplatin with DNA.

  1. Experience sharing, emotional reciprocity, and turn-taking

    Directory of Open Access Journals (Sweden)

    Melisa eStevanovic

    2015-04-01

    Full Text Available In this perspective article, we consider the relationship between experience sharing and turn-taking. There is much evidence suggesting that human social interaction is permeated by two temporal organizations: (1 the sequential framework of turn-taking and (2 the concurrent framework of emotional reciprocity. From this perspective, we introduce two alternative hypotheses about how the relationship between experience sharing and turn-taking could be viewed. According to the first hypothesis, the home environment of experience sharing is in the concurrent framework of emotional reciprocity, while the motivation to share experiences is in tension with the sequential framework of turn-taking. According to the second hypothesis, then again, people’s inclination to coordinate their actions in terms of turn-taking is motivated precisely by their propensity to share experiences. We consider theoretical and empirical ideas in favor of both of these hypotheses and discuss their implications for future research.

  2. Galpha(q) and phospholipase C-beta: turn on, turn off, and do it fast.

    Science.gov (United States)

    Ross, Elliott M

    2011-02-08

    Heterotrimeric G proteins and G protein-coupled receptors represent conserved protein families with origins in the prokaryotes, but the various G protein-regulated effectors are heterogeneous in structure and function. The effectors apparently evolved ways to listen to G proteins late in their evolutionary histories. The structure of a complex between the effector protein phospholipase C-β3 (PLC-β3) and its activator, Gα(q), suggests that several effectors independently evolved a structurally similar helix-turn-helix segment for G protein recognition. PLC-βs are also guanosine triphosphatase (GTPase)-activating proteins (GAPs) for the G(q) that activates them. In a second example of convergent evolution, the GAP activity of these proteins depends on a flexible asparagine-containing loop that resembles the GAP site on RGS proteins, another family of G protein GAPs. Together, these two sites are proposed to cooperate to enable fast binding to activated Gα(q), followed by fast deactivation. This cycle allows rapid sampling of the activation state of G(q)-coupled receptors while providing efficient signal transduction.

  3. Synchrotron-Based Highest Resolution FTIR Spectroscopy of Azulene, Naphthalene (C_{10}H_8), Indole (C_{8}H_6N) and Biphenyl (C_{12}H_{10})

    Science.gov (United States)

    Albert, S.; Quack, M.; Lerch, Ph.

    2013-06-01

    Great progress has been made in resolution (Δν≤ 20 MHz) and sensitivity in the field of high resolution Fourier transform infrared (FTIR) spectroscopy over the last decade. In particular, the use of synchrotron sources such as the Swiss Light Source (SLS) have overcome one of the disadvantages of high resolution FTIR spectroscopy, the problem of noise related to modest signal strength with broad band coverage from weak light sources. FTIR spectroscopy with synchrotron sources now makes it possible to investigate scientific questions of fundamental physics and astrophysics. One of the great challenges of astronomical infrared spectroscopy is the identification of the Unidentified Infrared Bands (UIBs) found in several interstellar objects. Polycyclic Aromatic Hydrocarbons (PAHs) have been proposed to be the carrier of the UIBs For that reason we have started to investigate with our ETH-SLS interferometer the rotationally resolved FTIR spectra of the bicyclic molecules naphthalene (C_{10}H_8)^d and azulene (C_{10}H_8) as a simple prototypical spectrum for a PAH infrared spectrum and of indole (C_{8}H_6N) as a prototype of a bicyclic heteroaromatic system. We have analysed in high resolution the ν_{46} band of naphthalene, the ν_{35} and 2ν_{40} bands of indole as well as the ν_{44} band of azulene. We have found a coincidence between the ν_{46} fundamental of naphthalene and the UIB at 12.78 μm. A comparison of the biphenyl FTIR spectrum with the UIBs in the range 13 to 15 μm illustrates a coincidence between the UIBs at 13.6 μm and 14.2 μm with the major biphenyl bands. S. Albert, K. Keppler Albert and M. Quack, Trend in Optics and Photonics 2003, 84, 177-180. S. Albert and M. Quack, ChemPhysChem, 2007, 8, 1271-1281. S. Albert, K. Keppler Albert and M. Quack, High Resolution Fourier Transform Infrared Spectroscopy in Handbook of High Resolution Spectroscopy, Vol. 2 (Eds. M. Quack and F. Merkt), Wiley, Chicester 2011, 965-1021. S. Albert, K.K. Albert, Ph

  4. Diamond turning of Si and Ge single crystals

    Energy Technology Data Exchange (ETDEWEB)

    Blake, P.; Scattergood, R.O.

    1988-12-01

    Single-point diamond turning studies have been completed on Si and Ge crystals. A new process model was developed for diamond turning which is based on a critical depth of cut for plastic flow-to-brittle fracture transitions. This concept, when combined with the actual machining geometry for single-point turning, predicts that {open_quotes}ductile{close_quotes} machining is a combined action of plasticity and fracture. Interrupted cutting experiments also provide a meant to directly measure the critical depth parameter for given machining conditions.

  5. Observation of diamond turned OFHC copper using Scanning Tunneling Microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Grigg, D.A.; Russell, P.E.; Dow, T.A.

    1988-12-01

    Diamond turned OFHC copper samples have been observed within the past few months using the Scanning Tunneling Microscope. Initial results have shown evidence of artifacts which may be used to better understand the diamond turning process. The STM`s high resolution capability and three dimensional data representation allows observation and study of surface features unobtainable with conventional profilometry systems. Also, the STM offers a better quantitative means by which to analyze surface structures than the SEM. This paper discusses findings on several diamond turned OFHC copper samples having different cutting conditions. Each sample has been cross referenced using STM and SEM.

  6. APPLIANCE OF COMPETITORS TECHNIQUES IN LEADING THE SKIES IN TURNING

    Directory of Open Access Journals (Sweden)

    Rašid Hadžić

    2009-11-01

    Full Text Available Competitors techniques in skiing characterize driving on edges, without gliding in certain fazes of turning. Today that characteristic is more and more present in all di- scipline, (downhill, super G, giant slalom and slalom so we can talk about appliance of basic technique of leading skies on all disciplines, with differences in position of skies in amplitude of moving and frequencies of changes of edges. From that point of view we distinct three typical shape of moving in turning, which have mutual distinction in influence on ski loading, and that has influence on tur- ning line and acceleration or checking in certain fazes of turning.

  7. A Multi-Turn Measurement System for the CERN PS

    CERN Document Server

    Angoletta, Maria Elena

    2002-01-01

    Multi-turn beam position measurements on one or more pickups provide very important information needed to derive machine optics parameters. A variety of analyses is possible, such as determination of phase advance, detuning with amplitude, and most important, the exploration of phase space. In this paper we present a new multi-turn acquisition system for the CERN Proton Synchrotron based on a CompactPCI fast digitiser and a new general object-oriented visualisation and analysis tool for the acquired multi-turn data.

  8. The ontological turn meets the certainty of death.

    Science.gov (United States)

    McDonald, Maryon

    2017-08-01

    The 'ontological turn' involves some anthropological points of long standing but the approaches recently coordinated into this turn have been presented as a 'call to arms', as shaking up 'mono-realist singularities' and as inherently political. This fighting talk has no doubt made important contributions to anthropology and insights from the ontological turn can help in anthropological understandings of medical practices. However, this paper contends that this helpfulness is also limited and that a call to arms may be inappropriate. This point is made through an ethnographic understanding of medical concern about the diagnosis of death.

  9. ANALYSIS OF CHIP FORMATION DURING HARD TURNING THROUGH ACOUSTIC EMISSION

    Directory of Open Access Journals (Sweden)

    Miroslav Neslušan

    2012-01-01

    Full Text Available The paper deals with analysis of chip formation and related aspects of the chip formation during turning hardened steel 100Cr6. The paper draws a comparison of some aspects of the chip formation between turning annealed and hardened roll bearing steel. The results of the analysis show that there is the formation of a segmented chip in the case of hard turning. Frequency of segmentation is very high. A conventional piezoelectric dynamometer limits the frequency response to about 3.5 kHz. On the other hand, the frequency of process fluctuation may by obtained by using accelerometers or acoustic emission. This paper reports about the dynamic character of cutting process when hard turning and correlation among the calculated segmentation frequencies and the experimental analysis.

  10. Models and Algorithms for Tracking Target with Coordinated Turn Motion

    Directory of Open Access Journals (Sweden)

    Xianghui Yuan

    2014-01-01

    Full Text Available Tracking target with coordinated turn (CT motion is highly dependent on the models and algorithms. First, the widely used models are compared in this paper—coordinated turn (CT model with known turn rate, augmented coordinated turn (ACT model with Cartesian velocity, ACT model with polar velocity, CT model using a kinematic constraint, and maneuver centered circular motion model. Then, in the single model tracking framework, the tracking algorithms for the last four models are compared and the suggestions on the choice of models for different practical target tracking problems are given. Finally, in the multiple models (MM framework, the algorithm based on expectation maximization (EM algorithm is derived, including both the batch form and the recursive form. Compared with the widely used interacting multiple model (IMM algorithm, the EM algorithm shows its effectiveness.

  11. Extended phenotype: nematodes turn ants into bird-dispersed fruits

    DEFF Research Database (Denmark)

    Hughes, D P; Kronauer, D J C; Boomsma, J J

    2008-01-01

    A recent study has discovered a novel extended phenotype of a nematode which alters its ant host to resemble ripe fruit. The infected ants are in turn eaten by frugivorous birds that disperse the nematode's eggs.......A recent study has discovered a novel extended phenotype of a nematode which alters its ant host to resemble ripe fruit. The infected ants are in turn eaten by frugivorous birds that disperse the nematode's eggs....

  12. Performances of cutting fluids in turning. Vegetable based oil - RV

    DEFF Research Database (Denmark)

    Axinte, Dragos Aurelian; Belluco, Walter

    1999-01-01

    Scope of the present measurement campaign is the evaluation of the cutting fluid performance. The report presents the standard routine and the results obtained when turning stainless steel and brass with a commercial vegetable based oil called RV. The methods were developed to be applicable...... in normal workshop conditions using common equipment for turning as well as in a test laboratory. The evaluation tests can be carried out using the desired number of repetitions in terms of workpiece materials and tools....

  13. Performances of cutting fluids in turning. Mineral oil - RM

    DEFF Research Database (Denmark)

    Axinte, Dragos Aurelian; Belluco, Walter

    1999-01-01

    Scope of the present measurement campaign is the evaluation of the cutting fluid performance. The report presents the standard routine and the results obtained when turning stainless steel and brass with a commercial vegetable based oil called RM. The methods were developed to be applicable...... in normal workshop conditions using common equipment for turning as well as in a test laboratory. The evaluation tests can be carried out using the desired number of repetitions in terms of workpiece materials and tools....

  14. NEUROPSYCHOLOGICAL PREDICTORS OF SAFETY IN URBAN LEFT-TURN SCENARIOS.

    Science.gov (United States)

    Dawson, Jeffrey D; Yu, Lixi; Chen, Kuan-Hua; Rusch, Michelle; Johnson, Amy M; Aksan, Nazan S; Sunda, Takashi; Hiramatsu, Machiko; Anderson, Steven W; Rizzo, Matthew

    2013-06-01

    Left turns at urban intersections can be dangerous, especially when views are obstructed or pedestrians are present. Impairments in driver vision, motor, and cognition functions may further increase left-turn risk. We examined this problem in a simulated environment that included left-turn scenarios to study the driving behaviors of 28 drivers, ages 37 to 88 years, six of whom had "Useful Field of View" (UFOV) impairments. Subjects also completed a battery of neuropsychological tests. The simulated drive included an urban section with six left turns in three types of scenarios: 1) a semi truck blocking the view of oncoming traffic, 2) a lead vehicle obstruction, and 3) a pedestrian crossing ahead of the turning driver. Results showed a mean (SD) of 1.46 (1.60) collisions per driver (range 0 to 7), 83% of which occurred at intersections with semi trucks. Far visual acuity, contrast sensitivity, UFOV, Mini Mental State Examination, Trail-Making Test Part B, the Wisconsin Card Sort task, and age were all associated with the total number of collisions (Pearson correlation magnitudes between 0.37 to 0.77; p-values<0.05). Spearman correlations were less significant. Findings indicate that visual obstruction by on oncoming semi-truck is a particularly dangerous left-turn situation.

  15. Thermal properties of Zn2(C8H4O4)2?C6H12N2 metal-organic framework compound and mirror symmetry violation of dabco molecules

    OpenAIRE

    Kozlova, Svetlana G.; Gabuda, Svyatoslav P.

    2017-01-01

    Thermal properties of Zn2(C8H4O4)2?C6H12N2 metal-organic framework compound at 8?300?K suggest the possibility of subbarrier tunnelling transitions between left-twisted (S) and right-twisted (R) forms of C6H12N2 dabco molecules with D3 point symmetry. The data agree with those obtained for the temperature behavior of nuclear spin-lattice relaxation times. It is shown that there is a temperature range where the transitions are stopped. Therefore, Zn2(C8H4O4)2?C6H12N2 and related compounds are ...

  16. Effect of transmitter turn-off time on transient soundings

    Science.gov (United States)

    Fitterman, D.V.; Anderson, W.L.

    1987-01-01

    A general procedure for computing the effect of non-zero turn-off time on the transient electromagnetic response is presented which can be applied to forward and inverse calculation methods for any transmitter-receiver configuration. We consider in detail the case of a large transmitter loop which has a receiver coil located at the center of the loop (central induction or in-loop array). For a linear turn-off ramp of width t0, the voltage response is shown to be the voltage due to an ideal step turn-off averaged over windows of width t0. Thus the effect is similar to that obtained by using averaging windows in the receiver. In general when time zero is taken to be the end of the ramp, the apparent resistivity increases for a homogeneous half-space over a limited time range. For time zero taken to be the start of the ramp the apparent resistivity is affected in the opposite direction. The effect of the ramp increases with increasing t0 and first-layer resistivity, is largest during the intermediate stage, and decreases with increasing time. It is shown that for a ramp turn-off, there is no effect in the early and late stages. For two-layered models with a resistive first layer (??1>??2), the apparent resistivity is increased in the intermediate stage. When the first layer is more conductive than the second layer (??1geoelectrical section on the turn-off effect. Neglecting the turn-off ramp will affect data interpretation as shown by field examples; the influence is the greatest on near-surface layer parameters. ?? 1987.

  17. Evaluation of cutting force uncertainty components in turning

    DEFF Research Database (Denmark)

    Axinte, Dragos Aurelian; Belluco, Walter; De Chiffre, Leonardo

    2000-01-01

    A procedure is proposed for the evaluation of those uncertainty components of a single cutting force measurement in turning that are related to the contributions of the dynamometer calibration and the cutting process itself. Based on an empirical model including errors form both sources......, the uncertainty for a single measurement of cutting force is presented, and expressions for the expected uncertainty vs. cutting parameters are proposed. This approach gives the possibility of evaluating cutting force uncertainty components in turning, for a defined range of cutting parameters, based on few...

  18. What happens when I turn on the TV set?

    OpenAIRE

    Nyre, Lars

    2007-01-01

    In a little known manuscript from 1998 Paddy Scannell asks some dumbfoundingly basic questions about the electronic media: ‘What happens when you turn on your television set? What is the meaning of television?’ The present article presents Scannell’s Heideggerian analysis of the act of turning on the TV set, and relates it to his other writings and lectures. The article doesn’t present Scannell’s work in its full breadth, but focuses on the technological dimension of mass communication. I als...

  19. Spatial turn and animation practices inspired by cultural anthropology

    Directory of Open Access Journals (Sweden)

    Agnieszka Wieszaczewska

    2016-09-01

    Full Text Available Spatial turn is one of the cultural turns, which have recently occurred in the humanities. It stresses the importance of issues such as space and place and can be successfully used as a theoretical perspective gaining use in thought over issues such as globalisation, transnationality, mapping but also education. In the discourses of pedagogical science space and place are considered through their multidimensional impact on education and learning. As significant concepts rooting pedagogy or pedagogy of borderland. The pedagogical reflection on space could be also used in the field of animation practices, especially in activities, which are related to place somehow colonised.

  20. A Cognitive Analysis of Truck Drivers’ Right-hand Turns

    DEFF Research Database (Denmark)

    Sieker, Tobias Grønborg; G. Skulason, Thorgeir; Sletting, Kristian

    2015-01-01

    This paper presents an investigation of truck drivers’ performance during right-hand turns performed in intersections with traffic lights in order to elicit the truck drivers’ domain, decision-making processes, and the strategies used while executing the turn. To gain knowledge about this, a truck...... driving instructor is interviewed, and four truck drivers are observed and interviewed. This results in a cognitive work analysis with the phases work domain analysis, control task analysis and strategies analysis. Through this study it is indicated that many different types of information are sought...

  1. Characterization of jellyfish turning using 3D-PTV

    Science.gov (United States)

    Xu, Nicole; Dabiri, John

    2017-11-01

    Aurelia aurita are oblate, radially symmetric jellyfish that consist of a gelatinous bell and subumbrellar muscle ring, which contracts to provide motive force. Swimming is typically modeled as a purely vertical motion; however, asymmetric activations of swim pacemakers (sensory organs that innervate the muscle at eight locations around the bell margin) result in turning and more complicated swim behaviors. More recent studies have examined flow fields around turning jellyfish, but the input/output relationship between locomotive controls and swim trajectories is unclear. To address this, bell kinematics for both straight swimming and turning are obtained using 3D particle tracking velocimetry (3D-PTV) by injecting biocompatible elastomer tags into the bell, illuminating the tank with ultraviolet light, and tracking the resulting fluorescent particles in a multi-camera setup. By understanding these kinematics in both natural and externally controlled free-swimming animals, we can connect neuromuscular control mechanisms to existing flow measurements of jellyfish turning for applications in designing more energy efficient biohybrid robots and underwater vehicles. NSF GRFP.

  2. Turning shopping habits of young consumers into green

    NARCIS (Netherlands)

    Bialkova, Svetlana; van 't Erve, Sanne; van Hoof, Joris Jasper; Pruyn, Adriaan T.H.; Bigné, Enrique

    2014-01-01

    Consumers have strong shopping habits, and although being aware of sustainable issues, they hardly do green shopping. Therefore, a challenging question is: how to break the old shopping habits and turn those into green? The current study addresses this question looking at barriers and potential

  3. Optimization of turning process parameters by using grey-Taguchi

    African Journals Online (AJOL)

    DR OKE

    By applying Taguchi method the quality of manufactured goods, and engineering designs are developed by studying variations. In this work, an attempt has been made to solve the correlated multiple criteria optimization problem of turning process by considering three different process parameters viz. cutting-speed, feed ...

  4. Turn me on 100 easy ways to use solar energy

    CERN Document Server

    Kodis, Michelle

    2009-01-01

    HERE COMES THE SUN! With page after page of creative and innovative ideas for using this limitless form of energy, as well as thoughtfully compiled lists of useful resources, Turn Me On is an introductory guide to understanding the exciting advances in a progressing technology that harnesses the boundless power of the sun to bring us clean, renewable energy.

  5. On Kinesic Triadic Relations in Turn-Taking

    Science.gov (United States)

    Pike, Kenneth L.

    1975-01-01

    This article discusses three characteristics useful in defining the relations between speakers in the turn-taking aspects of conversation: the derivational history of personal relationships, stop-action pseudo-history versus dynamic compacted posing, and the criss-crossing of verbal versus kinetic axes. (Available from Semiotica, Co-Libri, P.O.…

  6. Thresholds, tipping and turning points for sustainability under climate change

    NARCIS (Netherlands)

    Werners, S.; Pfenninger, S.; van Slobbe, E.; Haasnoot, Marjolijn; Kwakkel, J.; Swart, R.J.

    2014-01-01

    We review four bodies of literature that suggest that thresholds, tipping and turning points are important focal points for sustainability under climate change that can help bridge the science–policy interface. For decision-makers a critical threshold is reached, the moment that climate change

  7. Optimization of turning process parameters by using grey-Taguchi ...

    African Journals Online (AJOL)

    The main objective of this study is to improve toughness and hardness of engineering material by changing the machining parameters of turning process. By applying Taguchi method the quality of manufactured goods, and engineering designs are developed by studying variations. In this work, an attempt has been made to ...

  8. Turn vs. Shape: Teachers Cope with Incompatible Perspectives on Angle

    Science.gov (United States)

    Kontorovich, Igor'; Zazkis, Rina

    2016-01-01

    This study is concerned with tensions between the two different perspectives on the concept of angle: angle as a static shape and angle as a dynamic turn. The goal of the study is to explore how teachers cope with these tensions. We analyze scripts of 16 in-service secondary mathematics teachers, which feature a dialogue between a teacher and…

  9. L&D Manual Turn Lane Storage Validation/Update

    Science.gov (United States)

    2012-08-01

    Queuing occurs at intersections mostly due to overflow or inadequacy of turn bays. The ODOT L&D : Manual Volume 1 has storage requirements for both signalized and unsignalized intersections. Figures : 401-9E and 401-10E of the L&D Manual provide the ...

  10. Turning Points of the Spherical Pendulum and the Golden Ratio

    Science.gov (United States)

    Essen, Hanno; Apazidis, Nicholas

    2009-01-01

    We study the turning point problem of a spherical pendulum. The special cases of the simple pendulum and the conical pendulum are noted. For simple initial conditions the solution to this problem involves the golden ratio, also called the golden section, or the golden number. This number often appears in mathematics where you least expect it. To…

  11. Social and Emotional Turn Taking for Embodied Conversational Agents

    NARCIS (Netherlands)

    Bruijnes, Merijn

    2012-01-01

    In this doctoral consortium paper I describe the theme of my research, the model-based generation of consistent emotional turn taking behavior in virtual human conversations and the evaluation of this behavior. My goal is to investigate and generate convincing social behavior in embodied

  12. Beyond 100 Tesla: Scientific experiments using single-turn coils

    Science.gov (United States)

    Portugall, Oliver; Solane, Pierre Yves; Plochocka, Paulina; Maude, Duncan K.; Nicholas, Robin J.

    2013-01-01

    Current opportunities and recent examples for research in magnetic fields well above 100 T using single-turn coils are discussed. After a general introduction into basic principles and technical constraints associated with the generation of Megagauss fields we discuss data obtained at the LNCMI Toulouse, where such fields are routinely used for scientific applications.

  13. Stable Food Crops Turning Into Commercial Crops: Case Studies Of ...

    African Journals Online (AJOL)

    Stable Food Crops Turning Into Commercial Crops: Case Studies Of Teff, Wheat And Rice In Ethiopia. ... attention is needed to female headed households in the process of commercial transformation of subsistence agriculture. The development and institutionalization of marketing extension warrants due consideration.

  14. Using Facebook Data to Turn Introductory Statistics Students into Consultants

    Science.gov (United States)

    Childers, Adam F.

    2017-01-01

    Facebook provides businesses and organizations with copious data that describe how users are interacting with their page. This data affords an excellent opportunity to turn introductory statistics students into consultants to analyze the Facebook data using descriptive and inferential statistics. This paper details a semester-long project that…

  15. Getting 'Entangled': Reflexivity and the 'Critical Turn' in Tourism Studies

    NARCIS (Netherlands)

    Ateljevic, I.; Harris, C.; Wilson, E.; Collins, F.L.

    2005-01-01

    Reflecting a broader postmodern shift to unmask the cultural politics of research and knowledge-making in academia, tourism studies as a field is demonstrating a notable `critical turn¿ ¿ a shift in thought that serves to provide and legitimise a space for more interpretative and critical modes of

  16. Diamond turning and polishing tests on new RSP aluminium alloys

    NARCIS (Netherlands)

    Horst, R. ter; Haan, M. de; Gubbels, G.P.H.; Senden, R.; Venrooy, B.W.H. van; Hoogstrate, A.M.

    2012-01-01

    For years now conventional aluminium 6061 T6 has widely been used for mirrors in astronomical instruments, being diamond turned or since a few years also being optically polished. This allows the development of optical systems that can be tested and operated at any temperature, without being

  17. Turning Sunlight into Electricity-Inorganic Solar Cells and Beyond

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 16; Issue 12. Turning Sunlight into Electricity - Inorganic Solar Cells and Beyond. A K Shukla. Volume 16 Issue 12 December 2011 pp 1294-1302. Fulltext. Click here to view fulltext PDF. Permanent link:

  18. Ten-metre walk, with or without a turn?

    NARCIS (Netherlands)

    van Herk, IEH; Arendzen, J. Hans; Rispens, P

    Objective: To compare results obtained using different procedures to measure 10-metre walking time. Design: Walking was limed over a straight 10 m, and over 5 m with return, Further, the time taken to turn was measured directly. Setting: Rehabilitation department of a university hospital. Subjects:

  19. Student Wellbeing and the Therapeutic Turn in Education

    Science.gov (United States)

    Wright, Katie

    2014-01-01

    This article considers current concerns with promoting student mental health and wellbeing against the backdrop of critiques of the "therapeutic turn" in education. It begins by situating accounts of "therapeutic education" within broader theorisation of therapeutic culture. In doing so, the importance of this work is…

  20. Spanish and American Turn-Taking Styles: A Comparative Study.

    Science.gov (United States)

    Berry, Anne

    A comparative study of turn-taking in North American and Spanish conversation investigated (1) differences in styles for the two cultures and (2) any resulting misinterpretation of communicative intentions. Data for the first were drawn from two dinner parties, one with four American women, conducted in English, and one with four Spanish-speaking…

  1. Freeform turning lathe with direct drives and aerostatic bearing

    Science.gov (United States)

    Guan, Chao-liang; Dai, Yi-fan; Yin, Zi-qiang; Yang, Fan

    2009-05-01

    More and more precision freeform parts are required by defense technology and national economy today and in the future. The applications of freeform parts have traditionally conformed to the limitations imposed by practical limits on high effective fabricating technology. Single point diamond turning is one of the important methods of machining freeform surface parts. Generally speaking, optical freeform surfaces have complex geometrical surface shapes and require ultra smooth surface (roughness down to 10nm) and high form accuracy (form accuracy down to several ten nanometers). So, the ultra precision turning lathe must improve the motion accuracy, dynamic stiffness and bandwidth of every axis. Direct drive technology combined with aerostatic bearing do not affect by frication and eliminate the micro-backlash and creeping; reduce the number of transmission element, shorten the transmitted chains and be propitious to improve dynamic stiffness and bandwidth. This paper presents a ultra precision diamond turning lathe with linear motor and aerostatic guide drive system. Combined with the lathe a FTS (Fast Tool Servo) system driven by voice coil actor is use to machining free form surface. The turning experiments show that this lathe can satisfy the requirement of machine freeform surface.

  2. Cutting power prediction model for turning of GFRP composites ...

    African Journals Online (AJOL)

    user

    Glass fiber reinforced plastic (GFRP) composite materials are replacing traditional engineering materials owing to their superior properties ... highly corrosive industrial applications. They are ... (2000) turning operation is one of the most important operation used for machine elements construction in manufacturing industries ...

  3. The turning of the wind in the atmospheric boundary layer

    DEFF Research Database (Denmark)

    Pena Diaz, Alfredo; Gryning, Sven-Erik; Floors, Rogier Ralph

    2014-01-01

    Here we use accurate observations of the wind speed vector to analyze the behavior with height of the wind direction. The observations are a combination of tall meteorological mast and long-range wind lidar measurements covering the entire atmospheric boundary layer. The observations were performed...... winds underpredict the turning of the wind and the boundary-layer winds in general....

  4. Statistics of transverse mode turn-on dynamics in VCSEL's

    OpenAIRE

    Dellunde i Clavé, Jaume; Torrent, M. C. (Maria Carme); Sancho, José M.; Shore, K. A.

    1997-01-01

    The turn-on process of a multimode VCSEL is investigated from a statistical point of view. Special attention is paid to quantities such as time jitter and bit error rate. The single-mode performance of VCSEL¿s during current modulation is compared to that of edge-emitting lasers.

  5. The Effect of Organic Matter Content and Turning Cycle on ...

    African Journals Online (AJOL)

    Composting is an old technology and farmers have applied it in sustainable agriculture. In municipal solid waste management, composting can form part of an integrated system in handling waste for disposal. This study investigated the effect of organic matter content and turning cycle on the composting process of ...

  6. Optimization of surface integrity in dry hard turning using RSM

    Indian Academy of Sciences (India)

    This paper investigates the effect of different cutting parameters (cutting speed, feed rate, and depth of cut) on surface integrity defined in terms of surface roughness and microhardness in dry hard turning process. The workpiece material used was hardened alloy steel AISI 52100 and it was machined on a CNC lathe with ...

  7. Bumblebee Homing: The Fine Structure of Head Turning Movements.

    Directory of Open Access Journals (Sweden)

    Norbert Boeddeker

    Full Text Available Changes in flight direction in flying insects are largely due to roll, yaw and pitch rotations of their body. Head orientation is stabilized for most of the time by counter rotation. Here, we use high-speed video to analyse head- and body-movements of the bumblebee Bombus terrestris while approaching and departing from a food source located between three landmarks in an indoor flight-arena. The flight paths consist of almost straight flight segments that are interspersed with rapid turns. These short and fast yaw turns ("saccades" are usually accompanied by even faster head yaw turns that change gaze direction. Since a large part of image rotation is thereby reduced to brief instants of time, this behavioural pattern facilitates depth perception from visual motion parallax during the intersaccadic intervals. The detailed analysis of the fine structure of the bees' head turning movements shows that the time course of single head saccades is very stereotypical. We find a consistent relationship between the duration, peak velocity and amplitude of saccadic head movements, which in its main characteristics resembles the so-called "saccadic main sequence" in humans. The fact that bumblebee head saccades are highly stereotyped as in humans, may hint at a common principle, where fast and precise motor control is used to reliably reduce the time during which the retinal images moves.

  8. Turning Sunlight into Electricity-Inorganic Solar Cells and Beyond

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 7. Turning Sunlight into Electricity - Inorganic Solar Cells and Beyond. A K Shukla. General Article Volume 11 Issue 7 July 2006 pp 42-50. Fulltext. Click here to view fulltext PDF. Permanent link:

  9. Understanding the Linguistic Turn and the Quest for Meaning ...

    African Journals Online (AJOL)

    Although the linguistic turn is usually described in historical terms this article aims at combing the significant historical transitions with systematic philosophical considerations. Against the background of earlier rationalistic and empiricist trends particular attention is given to the successive epistemic ideals manifest in the ...

  10. Body saccades of Drosophila consist of stereotyped banked turns

    NARCIS (Netherlands)

    Muijres, F.T.; Elzinga, M.J.; Iwasaki, N.A.; Dickinson, M.H.

    2015-01-01

    The flight pattern of many fly species consists of straight flight segments interspersed with rapid turns called body saccades, a strategy that is thought to minimize motion blur. We analyzed the body saccades of fruit flies (Drosophila hydei), using high-speed 3D videography to track body and wing

  11. Online Memorials 2.0: When Mourning Turns Social

    DEFF Research Database (Denmark)

    Gotved, Stine

    This paper investigates the turn from individual to social online mourning rituals and introduces a research project that follows a new memorial platform where the best from both sides are sought combined. The Danish online memorial site from 2000, mindet.dk, is about to launch in a version 2...

  12. Postcolonial turn : re-imagining anthropology and Africa

    NARCIS (Netherlands)

    Devisch, R.; Nyamnjoh, F.

    2011-01-01

    This book is a reflection on the mental decolonization of the postcolonialist turn in Africanist scholarship and is simultaneously a tribute to the late Professor Archibald Mafeje. A number of the articles, including the Introduction by A. Olukoshi and F. Nyamnjoh, are reprinted from the Codesria

  13. CNC Turning Technician. A Competency-Based Instructional System.

    Science.gov (United States)

    Sloan, Kelly; Hilley, Robert

    This competency-based curriculum guide for instructing students in using computer numerically controlled (CNC) turning machines is one of a series of instructional guides for the machinist field developed in Oklahoma. Although developed jointly with Baxter Technologies Corporation and oriented toward the Baxter Vo-Tec 2000 Future Builder CNC…

  14. A Rhetoric of Turns: Signs and Symbols in Education

    Science.gov (United States)

    Rutten, Kris; Soetaert, Ronald

    2014-01-01

    In our research and teaching we explore the value and the place of rhetoric in education. From a theoretical perspective we situate our work in different disciplines, inspired by major "turns": linguistic, cultural, anthropological/ethnographic, interpretive, semiotic, narrative, literary, rhetorical etc. In this article we engage in the…

  15. Turn around management of open-cast lignite mines in Kosovo; Turn Around Management der Braunkohletagebaue im Kosovo

    Energy Technology Data Exchange (ETDEWEB)

    Hoehna, U. [Vattenfall Europe Mining AG, Cottbus (Germany). Vattenfall Mining Consulting

    2008-03-15

    In their cooperation in turn around management of KEK, Vattenfall Europe Mining Consulting made an important contribution to supporting the Kosovo. In spite of limited resources and a short time available, many practical steps were taken, and effective, sustainable and safe operation of the open-cast mine was achieved. (orig.)

  16. Palladium-Catalyzed C8-Selective C-H Arylation of Quinoline N-Oxides: Insights into the Electronic, Steric and Solvation Effects on the Site-Selectivity by Mechanistic and DFT Computational Studies.

    Science.gov (United States)

    Stephens, David E; Lakey-Beitia, Johant; Atesin, Abdurrahman C; Ateşin, Tülay A; Chavez, Gabriel; Arman, Hadi D; Larionov, Oleg V

    2015-01-02

    We report herein a palladium-catalyzed C-H arylation of quinoline N-oxides that proceeds with high selectivity in favor of the C8-isomer. This site-selectivity is unusual for palladium, since all of the hitherto described methods of palladium-catalyzed C-H functionalization of quinoline N-oxides are highly C2-selective. The reaction exhibits a broad synthetic scope with respect to quinoline N-oxides and iodoarenes and can be significantly accelerated to sub-hour reaction times under microwave irradiation. The C8-arylation method can be carried out on gram scale and has excellent functional group tolerance. Mechanistic and Density Functional Theory (DFT) computational studies provide evidence for the cyclopalladation pathway and describe key parameters influencing the site-selectivity.

  17. The role of genetic variants in CYP2C8, LPIN1, PPARGC1A and PPARγ on the trough steady-state plasma concentrations of rosiglitazone and on glycosylated haemoglobin A1c in type 2 diabetes

    DEFF Research Database (Denmark)

    Stage, Tore B; Christensen, Mette M H; Feddersen, Søren

    2013-01-01

    events, mainly oedema, in patients with type 2 diabetes mellitus (T2D). METHODS: The data used in this study were obtained from the South Danish Diabetes Study including 371 T2D patients with a focus on the 187 patients who were treated with rosiglitazone. The study was a placebo-controlled, partly...... of CYP2C8*3 (n=32) (rs10509681 and rs11572080) had a statistically significantly lower mean C(ss,min) than wild types (n=106), and they also had a statistically significantly lower mean absolute difference in HbA1c during rosiglitazone treatment. Finally, the carriers of CYP2C8*3 had a lower odds ratio...

  18. Chimeric antibody c.8B6 to O-acetyl-GD2 mediates the same efficient anti-neuroblastoma effects as therapeutic ch14.18 antibody to GD2 without antibody induced allodynia.

    Directory of Open Access Journals (Sweden)

    Mickaël Terme

    Full Text Available BACKGROUND: Anti-GD2 antibody is a proven therapy for GD2-positive neuroblastoma. Monoclonal antibodies against GD2, such as chimeric mAb ch14.18, have become benchmarks for neuroblastoma therapies. Pain, however, can limit immunotherapy with anti-GD2 therapeutic antibodies like ch14.18. This adverse effect is attributed to acute inflammation via complement activation on GD2-expressing nerves. Thus, new strategies are needed for the development of treatment intensification strategies to improve the outcome of these patients. METHODOLOGY/PRINCIPAL FINDINGS: We established the mouse-human chimeric antibody c.8B6 specific to OAcGD2 in order to reduce potential immunogenicity in patients and to fill the need for a selective agent that can kill neuroblastoma cells without inducing adverse neurological side effects caused by anti-GD2 antibody immunotherapy. We further analyzed some of its functional properties compared with anti-GD2 ch14.18 therapeutic antibody. With the exception of allodynic activity, we found that antibody c.8B6 shares the same anti-neuroblastoma attributes as therapeutic ch14.18 anti-GD2 mAb when tested in cell-based assay and in vivo in an animal model. CONCLUSION/SIGNIFICANCE: The absence of OAcGD2 expression on nerve fibers and the lack of allodynic properties of c.8B6-which are believed to play a major role in mediating anti-GD2 mAb dose-limiting side effects-provide an important rationale for the clinical application of c.8B6 in patients with high-risk neuroblastoma.

  19. Preparação, caracterização e aplicação de fases estacionárias tipo C8 modificadas por óxidos metálicos para cromatografia líquida

    Directory of Open Access Journals (Sweden)

    Karen Goraieb

    2013-01-01

    Full Text Available This work describes three C8-stationary phases for high performance liquid chromatography based on silica metallized with ZrO2, TiO2 or Al2O3 layers, having poly(methyloctylsiloxane immobilized onto their surfaces. The stationary phases were characterized using XRF, XAS, FTIR, SEM and elemental analysis to determine the physical characteristics of the oxide and polysiloxane layers formed on the surfaces and chromatographically to evaluate the separation parameters. The results show the changes on the silica surface and allowed proposing a structure for the oxide layer, being observed tetrahedral and octahedral structures, what is completely new in the literature. The formation of a homogeneous layer of metallic oxide (TiO2 and ZrO2 was observed on the silica. The C8-titanized and C8-aluminized stationary phases presented good chromatographic performances, with good values of asymmetry and efficiency. All stationary phase presented few loss of the polymeric layer after the HPLC, indicating that this layer is well attached on the metalized support.

  20. Synthesis, crystal structures and properties of cis- and trans-isomers of [Pt{C 6H 4-4R 1-1-[C 8H 4N-3'-NOMe]}Cl 2(dmso)] (R 1 = H or Cl)

    Science.gov (United States)

    López, Concepción; Moya, Carlos; Basu, Pradipta K.; González, Asensio; Solans, Xavier; Font-Bardía, Mercè; Calvet, Teresa; Lalinde, Elena; Teresa Moreno, M.

    2011-07-01

    The study of the reactivity of the 3-methoxyimino-2-phenyl-3 H-indoles C 6H 4-4R 1-1-[C 8H 4N-3'-NOMe] [R 1 = Cl ( 1a) or H ( 1b)] with cis-[PtCl 2(dmso) 2] has allowed the isolation of trans-[Pt{C 6H 4-4R 1-1-[C 8H 4N-3'-NOMe]}Cl 2(dmso)] [R 1 = Cl ( 2a) or H ( 2b)] and cis-[Pt{C 6H 4-4R 1-1-[C 8H 4N-3'-NOMe]}Cl 2(dmso)]·CH 2Cl 2 [R 1 = Cl ( 3a) or H ( 3b)]. Their crystal structures confirm: (a) the existence of a Pt sbnd N indole bond, (b) the relative arrangement of the Cl - ligands ( trans in 2a and 2b or cis in 3a and 3b) and (c) the anti- ( E) configuration of the oxime. A comparative study of the spectroscopic and photo-optical properties of ligands and their platinum(II) complexes ( 2a, 2b, 3a and 3b) is also reported.

  1. Fluid dynamics of forward swimming and turning for jellyfish

    Science.gov (United States)

    Miller, Laura

    2012-11-01

    Jellyfish propel themselves through the water through periodic contractions of their elastic bells. Some jellyfish, such as the box jellyfish Tripedalia cystophora and the upside down jellyfish Cassiopea xamachana, can perform turns via asymmetric contractions of the bell and by generating asymmetries in the outflow opening of the bell. The fluid dynamics of jellyfish forward propulsion and turning is explored here using the immersed boundary method. The 2D and 3D Navier-Stokes equations are coupled to the motion of a simplified jellyfish represented by an elastic boundary. An adaptive and parallelized version of the immersed boundary method (IBAMR) is used to resolve the detailed structure of the vortex wake. The asymmetric contraction and structure of the jellyfish generates asymmetries in the starting and stopping vortices. This creates a diagonal jet and a net torque acting on the jellyfish.

  2. Performances of cutting fluids in turning. Formulated oil - E

    DEFF Research Database (Denmark)

    Axinte, Dragos A.; Steffanato, Simone

    Tool life is a parameter closely connected to the lubricating effect of a cutting fluid. Long tool life in turning corresponds to good lubrication and a process with good lubrication is preferred, since it normally results in lower tool wear and better surface quality. Cutting forces are mainly i...... important for understanding the mechanism of the cutting process itself and to perform in this way data about the influence of the cutting fluids.......Tool life is a parameter closely connected to the lubricating effect of a cutting fluid. Long tool life in turning corresponds to good lubrication and a process with good lubrication is preferred, since it normally results in lower tool wear and better surface quality. Cutting forces are mainly...

  3. Welcome to the revolution: The sensory turn and art history

    Directory of Open Access Journals (Sweden)

    Jenni Lauwrens

    2012-12-01

    Full Text Available Discourses concerned with the sensorially embodied subject have emerged since the 1990s in various disciplines including history, anthropology, sociology, geography, film studies and literary studies. The purpose of this article is to bring the conversation regarding audiences’ embodied engagement in culture closer to art history by investigating the implications of what has been termed the sensory turn for this discipline. One of the accusations lodged against art history by supporters of the multi-sensoriality of embodied human experience is its alleged ocularcentrism, the implication of which is a detached autonomous subject. In this article, the sensory turn is defined and contextualized, particularly in light of the body of criticism targeted at art history’s emphasis on the visual. The proposed ways in which art historians might usefully deal with audience’s embodied experiences of not only immersive installation works of art, but also artworks in traditional media, such as painting and photography, are teased apart.

  4. The spatial turn: geographical approaches in the history of science.

    Science.gov (United States)

    Finnegan, Diarmid A

    2008-01-01

    Over the past decade or so a number of historians of science and historical geographers, alert to the situated nature of scientific knowledge production and reception and to the migratory patterns of science on the move, have called for more explicit treatment of the geographies of past scientific knowledge. Closely linked to work in the sociology of scientific knowledge and science studies and connected with a heightened interest in spatiality evident across the humanities and social sciences this 'spatial turn' has informed a wide-ranging body of work on the history of science. This discussion essay revisits some of the theoretical props supporting this turn to space and provides a number of worked examples from the history of the life sciences that demonstrate the different ways in which the spaces of science have been comprehended.

  5. A Turn-Projected State-Based Conflict Resolution Algorithm

    Science.gov (United States)

    Butler, Ricky W.; Lewis, Timothy A.

    2013-01-01

    State-based conflict detection and resolution (CD&R) algorithms detect conflicts and resolve them on the basis on current state information without the use of additional intent information from aircraft flight plans. Therefore, the prediction of the trajectory of aircraft is based solely upon the position and velocity vectors of the traffic aircraft. Most CD&R algorithms project the traffic state using only the current state vectors. However, the past state vectors can be used to make a better prediction of the future trajectory of the traffic aircraft. This paper explores the idea of using past state vectors to detect traffic turns and resolve conflicts caused by these turns using a non-linear projection of the traffic state. A new algorithm based on this idea is presented and validated using a fast-time simulator developed for this study.

  6. Analysis of the influence of tool dynamics in diamond turning

    Energy Technology Data Exchange (ETDEWEB)

    Fawcett, S.C.; Luttrell, D.E.; Keltie, R.F.

    1988-12-01

    This report describes the progress in defining the role of machine and interface dynamics on the surface finish in diamond turning. It contains a review of literature from conventional and diamond machining processes relating tool dynamics, material interactions and tool wear to surface finish. Data from experimental measurements of tool/work piece interface dynamics are presented as well as machine dynamics for the DTM at the Center.

  7. The performative turn at Inhotim: installation art and Baudelairean modernity

    OpenAIRE

    Lauren S. Weingarden

    2013-01-01

    This article explores the participatory turn in installation art as part of a trajectory from Baudelairean modernity to twentyfirst-century postmodernity, as represented at Inhotim, the outdoor contemporary art museum and botanical gardens in Brumadinho, MG. In his 1862 essay “The Painter of ModernLife,” Charles Baudelaire defined modernity as fleeting, transitory and fragmentary. Baudelairean modernity initiated a breakdown of boundaries between art and life and between high art aesthetics a...

  8. Turning the tide : tidal power in the UK

    OpenAIRE

    Sustainable Development Commission

    2007-01-01

    Contents: Turning the tide : tidal power in the UK -- Executive summary -- Tidal power in the UK : research report 1 : UK tidal resource assessment -- Tidal power in the UK : research report 2 : tidal technologies overview -- Tidal power in the UK : research report 3 : Severn barrage proposals -- Tidal power in the UK : research report 4 : Severn non-barrage options -- Tidal power in the UK : research report 5 : UK case studies. Summarised in the Welsh language version of the executive ...

  9. Turning conditions of Ck 45 steel with alternate hardness zones

    OpenAIRE

    A. Stoić; J. Kopač; T. Ergić; M. Duspar

    2009-01-01

    Purpose: of this paper is investigation of dynamic impacts on cutting edge during machining of locally hardened steel. Alteration of hardness on a single work piece is a source of impact on tool, which could lead to breakage of cutting tool and work piece surface damage in turning. Influence of material properties (primary hardness) is important when work piece is hardened locally by induction and part of material is soft annealed.Design/methodology/approach: Experimental tests of cutting out...

  10. Machining parameter optimization in turning process for sustainable manufacturing

    OpenAIRE

    S. G. Dambhare; S. J. Deshmukh; A. B. Borade

    2015-01-01

    There is an increase in awareness about sustainable manufacturing process. Manufacturing industries are backbone of a country’s economy. Although it is important but there is a great concern about consumption of resources and waste creation. The primary aim of this study was to explore sustainability concern in turning process in an Indian machining industry. The effect of cutting parameters, Speed/Feed/Depth of Cut, the machining environment, Dry/MQL/Wet, and the type of cutting tool on sust...

  11. Online Memorials 2.0: When Mourning Turns Social

    DEFF Research Database (Denmark)

    Gotved, Stine

    This paper investigates the turn from individual to social online mourning rituals and introduces a research project that follows a new memorial platform where the best from both sides are sought combined. The Danish online memorial site from 2000, mindet.dk, is about to launch in a version 2.0, .......0, where the mourners in a dedicated space can use their sharing skills to co-construct the memorial....

  12. [Amazing health rates in turn-of-the-century Majorca].

    Science.gov (United States)

    Bujosa, F

    1998-01-01

    Majorca's mortality rates in the turn of the century were the lowest of Spain and nearer to those of the northern European countries than to Mediterranean ones and therefore their amazing quality. This paper seeks to contribute to solve that riddle and, as a first step, it reviews the island's demographic conditions and its economic, political and social and cultural context, including the analysis of the development of medical sciences and the sanitary reform of the city of Palma proposed by Eusebio Estada.

  13. The Digital Turn in the French Audiovisual Model

    OpenAIRE

    Olivier Alexandre

    2016-01-01

    This article deals with the digital turn in the French audiovisual model. An organizational and legal system has evolved with changing technology and economic forces over the past thirty years. The high-income television industry served as the key element during the 1980s to compensate for a shifting value economy from movie theaters to domestic screens and personal devices. However, the growing competition in the TV sector and the rise of tech companies have initiated a disruption process. A...

  14. GA based CNC turning center exploitation process parameters optimization

    Directory of Open Access Journals (Sweden)

    Z. Car

    2009-01-01

    Full Text Available This paper presents machining parameters (turning process optimization based on the use of artificial intelligence. To obtain greater efficiency and productivity of the machine tool, optimal cutting parameters have to be obtained. In order to find optimal cutting parameters, the genetic algorithm (GA has been used as an optimal solution finder. Optimization has to yield minimum machining time and minimum production cost, while considering technological and material constrains.

  15. Homer regulates calcium signalling in growth cone turning

    Directory of Open Access Journals (Sweden)

    Thompson Michael JW

    2009-08-01

    Full Text Available Abstract Background Homer proteins are post-synaptic density proteins with known functions in receptor trafficking and calcium homeostasis. While they are key mediators of synaptic plasticity, they are also known to function in axon guidance, albeit by mechanisms that are yet to be elucidated. Homer proteins couple extracellular receptors – such as metabotropic glutamate receptors and the transient receptor potential canonical family of cation channels – to intracellular receptors such as inositol triphosphate and ryanodine receptors on intracellular calcium stores and, therefore, are well placed to regulate calcium dynamics within the neural growth cone. Here we used growth cones from dorsal root ganglia, a well established model in the field of axon guidance, and a growth cone turning assay to examine Homer1 function in axon guidance. Results Homer1 knockdown reversed growth cone turning from attraction to repulsion in response to the calcium-dependent guidance cues brain derived neurotrophic factor and netrin-1. Conversely, Homer1 knockdown had no effect on repulsion to the calcium-independent guidance cue Semaphorin-3A. This reversal of attractive turning suggested a requirement for Homer1 in a molecular switch. Pharmacological experiments confirmed that the operational state of a calcium-calmodulin dependent protein kinase II/calcineurin phosphatase molecular switch was dependent on Homer1 expression. Calcium imaging of motile growth cones revealed that Homer1 is required for guidance-cue-induced rise of cytosolic calcium and the attenuation of spontaneous cytosolic calcium transients. Homer1 knockdown-induced calcium transients and turning were inhibited by antagonists of store-operated channels. In addition, immunocytochemistry revealed the close association of Homer1 with the store-operated proteins TRPC1 and STIM1 within dorsal root ganglia growth cones. Conclusion These experiments provide evidence that Homer1 is an essential

  16. Fuzzy Linguistic Optimization on Surface Roughness for CNC Turning

    Directory of Open Access Journals (Sweden)

    Tian-Syung Lan

    2010-01-01

    Full Text Available Surface roughness is often considered the main purpose in contemporary computer numerical controlled (CNC machining industry. Most existing optimization researches for CNC finish turning were either accomplished within certain manufacturing circumstances or achieved through numerous equipment operations. Therefore, a general deduction optimization scheme is deemed to be necessary for the industry. In this paper, the cutting depth, feed rate, speed, and tool nose runoff with low, medium, and high level are considered to optimize the surface roughness for finish turning based on L9(34 orthogonal array. Additionally, nine fuzzy control rules using triangle membership function with respective to five linguistic grades for surface roughness are constructed. Considering four input and twenty output intervals, the defuzzification using center of gravity is then completed. Thus, the optimum general fuzzy linguistic parameters can then be received. The confirmation experiment result showed that the surface roughness from the fuzzy linguistic optimization parameters is significantly advanced compared to that from the benchmark. This paper certainly proposes a general optimization scheme using orthogonal array fuzzy linguistic approach to the surface roughness for CNC turning with profound insight.

  17. What Happens Before a Southward IMF Turning Reaches the Magnetopause?

    Science.gov (United States)

    Samsonov, A. A.; Sibeck, D. G.; Dmitrieva, N. P.; Semenov, V. S.

    2017-09-01

    Previous observations have shown a ˜10-15 min time delay in the ionospheric response to solar wind directional discontinuities marked by either southward or northward interplanetary magnetic field (IMF) turnings. We have studied one southward IMF turning observed by Time History of Events and Macroscale Interactions during Substorms (THEMIS) and GOES in the dayside magnetosphere. Using a global MHD model, we have reproduced the magnetopause motion in this event. We find that the observed delay in the ground response can be completely explained by deceleration of the directional discontinuity in the subsolar magnetosheath. We show that the speed of the discontinuity significantly decreases in the vicinity of the magnetopause where the magnetic barrier formed during the previous northward IMF interval. The southward turning can reach the magnetopause only after complete disruption of the magnetic barrier. The disruption or dissipation occurs via magnetosheath reconnection, as confirmed by high-speed jets in the magnetosheath. The magnetopause moves sunward as the directional discontinuity transits the magnetosheath. This sunward motion is followed by the earthward motion when the discontinuity strikes the magnetopause and magnetopause reconnection begins.

  18. Turning points in long distance grandparent-grandchild relationships.

    Science.gov (United States)

    Bangerter, Lauren R; Waldron, Vincent R

    2014-04-01

    This study examines changes in long-distance relationships between grandparents and their adolescent grandchildren by identifying relational turning points and trajectories. Qualitative analysis of data collected from interviews with grandparents yielded 100 unique turning points. Constant comparative analysis revealed eight distinct categories of relational turning points; Spending Time Together, Family Relational Dynamics, Geographic Distance, Lack of Relational Investment, Use of Technology, Relational Investment, Lack of Free Time, and Grandchild Gaining Independence. These varied in the degree to which they positively or negatively impacted relational closeness. Application of the Retrospective Interview Technique (RIT) yielded five distinctive relational trajectories: Decrease in Closeness, Increase in Closeness, Multidimensional Changes in Closeness, Minimal Changes in Closeness, and Consistent Relational Closeness. The results expose the communicative challenges faced by long-distance-grandparents, the diversity of these relationships, and the ways in which grandparenting bonds change over time. Implications for an enriched understanding of grandparenting relationships and practical applications for families are explored. Copyright © 2014 Elsevier Inc. All rights reserved.

  19. Leibniz, Lefebvre and the spatial turn in law

    Directory of Open Access Journals (Sweden)

    Isolde de Villiers

    2016-02-01

    Full Text Available This contribution takes as its point of departure the spatial turn in law and the notion of spatial justice. It traces the term ‘spatial justice’ as introduced through the Spatial Planning and Land Use Management Act and it looks at the underlying view of space that has influenced the spatial turn in law. It furthermore investigates the ways in which the spatial turn in law has been influenced by the thinking of Henri Lefebvre, who relies on a Leibnizian conception of space. Lastly the link between Leibniz and legal positivism is considered in order to reach the final conclusion in the form of a caution against merely adding the language of spatial justice to an approach to space that remains caught up in abstract space. This will only further entrench existing fault lines in society. For this conclusion the work of Roger Berkowitz is central. Berkowitz argues convincingly that the work of Leibniz was central in the development of legal positivism, despite Leibniz in general being considered as a natural law thinker. The same applies to spatial justice theory, where the work of Leibniz is central: it may present the possibilities of another law – the law as it ought to be. The law conceptualised as ‘ought’ instead of ‘is’ would promote reconciliation. Alternatively, spatial justice can simply present the law as it ‘is’ and reconfirm and deepen the chasms in our world.

  20. Surface Corrosion Resistance in Turning of Titanium Alloy

    Directory of Open Access Journals (Sweden)

    Rui Zhang

    2015-01-01

    Full Text Available This work addresses the issues associated with implant surface modification. We propose a method to form the oxide film on implant surfaces by dry turning to generate heat and injecting oxygen-rich gas at the turning-tool flank. The morphology, roughness, composition, and thickness of the oxide films in an oxygen-rich atmosphere were characterized using scanning electron microscopy, optical profiling, and Auger electron spectroscopy. Electrochemical methods were used to study the corrosion resistance of the modified surfaces. The corrosion resistance trends, analyzed relative to the oxide film thickness, indicate that the oxide film thickness is the major factor affecting the corrosion resistance of titanium alloys in a simulated body fluid (SBF. Turning in an oxygen-rich atmosphere can form a thick oxide film on the implant surface. The thickness of surface oxide films processed at an oxygen concentration of 80% was improved to 4.6 times that of films processed at an oxygen concentration of 21%; the free corrosion potential shifted positively by 0.357 V, which significantly improved the corrosion resistance of titanium alloys in the SBF. Therefore, the proposed method may (partially replace the subsequent surface oxidation. This method is significant for biomedical development because it shortens the process flow, improves the efficiency, and lowers the cost.

  1. Turning Rate Dynamics of Zebrafish Exposed to Ethanol

    Science.gov (United States)

    Mwaffo, Violet; Porfiri, Maurizio

    2015-06-01

    Zebrafish is emerging as a species of choice in alcohol-related pharmacological studies. In these studies, zebrafish are often exposed to acute ethanol treatments and their activity scored during behavioral assays. Computational modeling of zebrafish behavior is expected to positively impact these efforts by offering a predictive toolbox to plan hypothesis-driven studies, reduce the number of subjects, perform pilot trials, and refine behavioral screening. In this work, we demonstrate the use of the recently proposed jump persistent turning walker to model the turning rate dynamics of zebrafish exposed to acute ethanol administration. This modeling framework is based on a stochastic mean reverting jump process to capture the sudden and large changes in orientation of swimming zebrafish. The model is calibrated on an available experimental dataset of 40 subjects, tested at different ethanol concentrations. We demonstrate that model parameters are modulated by ethanol administration, whereby both the relaxation rate and jump frequency of the turning rate dynamics are influenced by ethanol concentration. This effort offers a first evidence for the possibility of complementing zebrafish pharmacological research with computational modeling of animal behavior.

  2. Magnetic Circuit Analyses and Turning Chatter Suppression Based on a Squeeze-Mode Magnetorheological Damping Turning Tool

    Directory of Open Access Journals (Sweden)

    Yongliang Zhang

    2015-01-01

    Full Text Available As a smart material, magnetorheological fluid (MRF has been utilized in fields including civil engineering and automotive engineering, and so on. In this study, the MR damping turning tool based on the squeeze-mode was developed to improve the vibration resistance of the tool system on the lathe. The 3D magnetic circuit simulations of the damper were performed. The influences of damper structural parameters, such as coil positions, plate thicknesses, and others, on the magnetic induction strength were investigated. Orthogonal experiments were carried out and the optimal combination of damper parameters was determined. The chatter suppressive experiments were carried out to evaluate the performance of the MR damping turning tool.

  3. A Bunch-By-Bunch and Turn-By-Turn Instrumentation Hardware Upgrade for CESR-c

    CERN Document Server

    Palmer, Mark A; Strohman, Charles R; Tanke, Eugene

    2005-01-01

    A key factor in the colliding beam performance of the Cornell Electron Storage Ring (CESR) is the impact of parasitic beam-beam interactions between bunches in the two beams as they follow their electrostatically separated orbits in a single vacuum chamber. In order to better investigate the differential performance of bunches in CESR, instrumentation electronics has been developed to allow acquisition of turn-by-turn data from multiple bunches simultaneously. The electronics consists of a standardized digital board centered around an Analog Devices TigerSHARC family digital signal processor, a communications interface, and an interface to the CESR Precision Timing System. Mated to these components is an analog front end and digitizer board which is customized for the particular diagnostic device of interest. Front ends have been developed for beam position monitor, luminosity monitor, and beam profile monitor applications. We describe the design and characterization of this new hardware.

  4. Medium dependent dual turn on/turn off fluorescence sensing for Cu2+ions using AMI/SDS assemblies.

    Science.gov (United States)

    Gujar, Varsha B; Ottoor, Divya

    2017-02-15

    Behavior of Amiloride (AMI) as a metal ion sensor in anionic surfactant assemblies of varying concentrations at different pH is depicted in this work. From a non-sensor fluorophore, AMI has been transformed in to a tunable fluorosensor for Cu 2+ ions in various SDS concentrations. At premicellar concentration of SDS, ion-pair complex is expected to be formed between AMI and SDS due to electrostatic interactions between them. However at CMC concentrations of SDS, fluorescence intensity of AMI is greatly enhanced with red shift in emission, due to the incorporation of AMI molecule in the hydrophobic micellar interface. The behavior of metal sensing by AMI-SDS assemblies gives rise to several interesting observations. Micellation of SDS has been greatly enhanced by increasing copper ion concentrations, as these counter ions screens the charge on monomers of SDS which lead to the aggregation at premicellar concentrations only. Concentrations and pH dependent discrete trends of interactions between SDS-AMI and SDS-Cu 2+ ions, have given tunable fluorescence responses (fluorescence turn on/turn off) of AMI for added Cu 2+ ions. The electrostatic interaction between the metal cations and the anionic surfactants is the driving force for bringing the metal ions near to the vicinity of micelle where AMI resides. Thus, a comprehensive understanding of the mechanism related to the 'turn on-turn off' fluorescence response of AMI with respect to pH and SDS concentration for effective Cu 2+ ion sensing is illustrated in this work. Copyright © 2016 Elsevier B.V. All rights reserved.

  5. Simulation of turn-by-turn passage of protons through the H-minus stripping foil in booster

    Energy Technology Data Exchange (ETDEWEB)

    Gardner, C. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2017-07-06

    Equations for transverse emittance growth due to multiple passes of circulating proton beam through the H-minus stripping foil in Booster were developed in [1]. These were based on simple principles of statistics and simple assumptions about the initial distribution of particles incident on the foil. It was assumed there that the foil dimensions and position of the incoming beam are such that all particles hit the foil on every turn around the machine. In the present note we assume only that all incoming H-minus ions from Linac hit the foil and are stripped of their electrons. The resulting protons circulate indefinitely around the machine. Setups in which the foil width is reduced so that not all protons hit the foil on every turn are studied here by simulation. The aim is to determine the effectiveness of such setups in reducing the emittance growth of circulating proton beam during the injection of H-minus beam. The simulations also serve as a check of the equations developed in [1], and vice versa. The particulars of the simulation setup are given in Sections 1 through 11. Figures 1 through 12 show simulation results for the case in which all particles hit the foil on every turn. The results are in good agreement with those obtained from the equations of reference [1]. Figures 13 through 19 show simulation results for various setups in which the foil width is reduced. These results are summarized in Section 12. In all gures the horizontal axis gives the turn number. The unit of the vertical axis is micrometers ( m) in all plots of emittance.

  6. Serials cataloging at the turn of the century

    CERN Document Server

    Williams, James W

    2014-01-01

    An overview of the research topics and trends that have appeared over the last five years, Serials Cataloging at the Turn of the Century doesn't just tell you that there has been a lot of change--that the information environment is something of a chameleon, always beguiling and slipping out of grasp. Instead, it gives you the plain facts on the specific challenges serials catalogers have been facing and how they're meeting adversity head-on, ready to gain the advantage in the rumble with proliferating information and formats.Comprehensive, resource-packed, and easy-to-digest, Serials Catalogin

  7. Resonant Multi-Turn Extraction Principle and Experiments

    CERN Document Server

    Gilardoni, S S; Martini, M; Métral, E; Scaramuzzi, P; Steerenberg, R; Muller, AS

    2006-01-01

    Recently a novel approach to perform multi-turn extraction was proposed based on beam splitting in the transverse phase space by means of trapping inside stable islands. In addition to numerical simulations, aimed at assessing the feasibility of the proposed technique, an experimental campaign was launched since the year 2002 at the CERN Proton Synchrotron. During the year 2004 run, a high-intensity single-bunch beam was successfully split and the generated beamlets separated without any measurable losses. The underlying principle will be presented and discussed in details in this paper, as well as the latest experimental results and future applications.

  8. Resonant multi-turn extraction: Principle and experiments

    CERN Document Server

    Gilardoni, S S; Martini, M; Métral, E; Scaramuzzi, P; Steerenberg, R; Müller, A S

    2006-01-01

    Recently, a novel approach to perform multi-turn extraction was proposed based on beam splitting in the transverse phase space by means of trapping inside stable islands. In addition to numerical simulations, aimed at assessing the feasibility of the proposed technique, an experimental campaign was launched since the year 2002 at the CERN Proton Synchrotron. During the year 2004 run, a high-intensity single-bunch beam was successfully split and the generated beamlets separated without any measurable losses. The underlying principle will be presented and discussed in details in this paper, as well as the latest experimental results and future applications.

  9. Big data analytics turning big data into big money

    CERN Document Server

    Ohlhorst, Frank J

    2012-01-01

    Unique insights to implement big data analytics and reap big returns to your bottom line Focusing on the business and financial value of big data analytics, respected technology journalist Frank J. Ohlhorst shares his insights on the newly emerging field of big data analytics in Big Data Analytics. This breakthrough book demonstrates the importance of analytics, defines the processes, highlights the tangible and intangible values and discusses how you can turn a business liability into actionable material that can be used to redefine markets, improve profits and identify new business opportuni

  10. Turn and jump: how time & place fell apart

    CERN Document Server

    Mansfield, Howard

    2013-01-01

    Before Thomas Edison, light and fire were thought to be one and the same. Turns out, they were separate things altogether. This book takes a similar relationship, that of time and place, and shows how they, too, were once inseparable. Time keeping was once a local affair, when small towns set their own pace according to the rising and setting of the sun. Then, in 1883, the expanding railroads necessitated the creation of Standard Time zones, and communities became linked by a universal time. Here Howard Mansfield explores how our sudden interconnectedness, both physically, as through the railroad, and through inventions like the telegraph, changed our concept of time and place forever.

  11. Geometry of single-point turning tools and drills

    CERN Document Server

    Astakhov, Viktor P

    2010-01-01

    Tools for metal cutting have many shapes and features, each of which is described by its angles or geometries. The selection of the right cutting tool geometry is critical because it directly affects the integrity of the machined surface, tool life, power needed for machining, and thus the overall machining efficiency. ""Geometry of Single-Point Turning Tools and Drills"" outlines clear objectives of cutting tool geometry selection and optimization, using multiple examples to provide a thorough explanation. The establishment of clear bridges between cutting theory, tool geometry, and shop prac

  12. Why nature doesn't turn off neurosis.

    Science.gov (United States)

    Badalamenti, Anthony F

    2013-03-01

    This paper develops an integration of psychoanalytic and wisdom tradition concepts to answer the question as to why nature does not turn off neurosis, The proposed answer is that nature wants a person to exploit the neurosis for two gains, one being the increase in adaptive capacity resulting from releasing it and the second involving the difficulty in the release itself, the latter related to gains proffered by the world's wisdom traditions. These see a movement from the psyche's creation by passive, unconscious means of finite promise rooted in parental love to creation by active, consciously chosen means of unlimited promise involving a direct relationship with nature and the Cosmos.

  13. Tool life of ceramic wedges during precise turning of tungsten

    Directory of Open Access Journals (Sweden)

    Legutko Stanislaw

    2017-01-01

    Full Text Available Properties, application and machinability of tungsten and its alloys have been demonstrated. The comparison of the tool life and wear of the wedges made of SiAlON and whisker ceramics during the precise turning at different cutting parameters have been presented. The CNC lathe DMG CTX 310 Ecoline and tungsten of 99.7 % purity were used during the experiments. Only the wedge of whisker ceramics has proved to be sufficiently suitable and only for relatively low cutting speeds.

  14. The embodied turn in research on language and social interaction

    DEFF Research Database (Denmark)

    Nevile, Maurice

    2015-01-01

    I use the term the embodied turn to mean the point when interest in the body became established among researchers on language and social interaction, exploiting the greater ease of video-recording. This review paper tracks the growth of "embodiment" in over 400 papers published in Research...... on Language and Social Interaction from 1987-2013. I consider closely two areas where analysts have confronted challenges, and how they have responded: settling on precise and analytically helpful terminology for the body; and transcribing and representing the body, particularly its temporality and manner....

  15. Convective heat transfer in ribbed channels with a 180 turn

    Energy Technology Data Exchange (ETDEWEB)

    Astarita, T.; Cardone, G.; Carlomagno, G.M. [University of Naples Federico II, DETEC, P. le Tecchio, 80-80125 Naples (Italy)

    2002-07-01

    Detailed quantitative maps of the heat transfer distribution near a 180 sharp turn of a square channel with rib turbulators are measured by means of infrared thermography associated with the heated-thin-foil technique. Air flows into the channel where ribs are mounted on two opposite walls and placed at 60 with respect to its axis. Two rib pitches, two different rib arrangements and two heating conditions are investigated. Results are presented in terms of local and averaged Nusselt numbers which are normalized with the classical Dittus and Boelter correlation for three different Reynolds numbers. (orig.)

  16. GIS: A Spatial Turn in the Health Science?

    DEFF Research Database (Denmark)

    Schipperijn, Jasper; Ejstrud, Bo; Troelsen, Jens

    2013-01-01

    In recent years health science seems to have taken a “spatial turn” with a renewed interest in spatially oriented research. There are a number of reasons behind this rediscovery of “the power of maps”. One of the predominant drivers has been the development of Geographical Information Systems (GIS...... of the available GIS data. With the increased use of GIS, the limitations of existing GIS data are becoming more apparent. However, we expect that methodological and technical developments will increase the usefulness and validity of using GIS-derived environmental parameters in health research, which in turn...

  17. 77 FR 72747 - Alkyl(C8

    Science.gov (United States)

    2012-12-06

    ... ) dimethylamidopropylamines in food as using the I-Dietary Exposure Evaluation Model (I-DEEM). I-DEEM is a highly conservative..., LLC, submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting..., food manufacturer, or pesticide manufacturer. The following list of North American Industrial...

  18. Effects of cutting parameters during turning 100C6 steel

    Directory of Open Access Journals (Sweden)

    Chibane H.

    2010-06-01

    Full Text Available The objective of the paper is to evaluate the effects of cutting parameters in terms of cutting speed, depth of cut and feed rate on the influence of the surface roughness, consumed power, cutting time and tool vibrations during turning process. The material chosen in this case was 100C6 steel in dry conditions. The effects of the selected process parameters have been investigated using full factorial design of experiments (33 and the multiple linear regression (MLR. Thus, first-order empirical models were established. Analysis of variance (ANOVA was employed to check the validity of the developed models within the limits of the factors that were being investigated and to test the significance of the above parameters. Results indicate that the feed rate is the only significant factor affecting the surface roughness. The cutting speed and feed rate are the most influential factors on cutting time. Estimated tool vibrations are functions of cutting speed, feed rate and depth of cut in decreasing order. Finally, the models obtained can be used for determination of optimal settings of cuttings parameters and this methodology should help us to obtain the best process parameters for dry turning of 100C6 steel.

  19. Body Segment Parameters During GS Turn in Recreational Skiers

    Directory of Open Access Journals (Sweden)

    Mijo Curic

    2017-06-01

    Full Text Available Study aim was to analyze the kinematic parameters of the body of the examinees, without competitive experience in skiing, in order to determine the competitive efficiency. The participants in this research were 23 male students from the Faculty of physical education and sport, aged 22±6 months, who attended the classes in the subject alpine skiing. Examinees were divided into two categories, according to duration of the course run, in order to determine whether there is the differences in body segment parameters during giant slalom turn. Using Independent Samples t-test we see that the examinees differ on a statistically significant level in variables duration of the turn p=0.000, duration of the course run p=0.000 and inclination of the body p=0.030, and that the differences are in favor of faster examinees. The analysis of the results in this research has shown that there is a relation between the measured body segment parameters and duration of the course run, or that the technique of skiing has a direct impact on the competition in alpine skiing.

  20. Improved Turn-on Characteristics of Fast High Current Thyristors

    CERN Document Server

    Ducimetière, L; Vossenberg, Eugène B

    1999-01-01

    The beam dumping system of CERN's Large Hadron Collider (LHC) is equipped with fast solid state closing switches, designed for a hold-off voltage of 30 kV and a quasi half sine wave current of 20 kA, with 3 ms rise time, a maximum di/dt of 12 kA/ms and 2 ms fall time. The design repetition rate is 20 s. The switch is composed of ten Fast High Current Thyristors (FHCT’s), which are modified symmetric 4.5 kV GTO thyristors of WESTCODE. Recent studies aiming at improving the turn-on delay, switching speed and at decreasing the switch losses, have led to test an asymmetric not fully optimised GTO thyristor of WESTCODE and an optimised device of GEC PLESSEY Semiconductor (GPS), GB. The GPS FHCT, which gave the best results, is a non irradiated device of 64 mm diameter with a hold-off voltage of 4.5 kV like the symmetric FHCT. Tests results of the GPS FHCT show a reduction in turn-on delay of 40 % and in switching losses of almost 50 % with respect to the symmetric FHCT of WESTCODE. The GPS device can sustain an i...

  1. Machining parameter optimization in turning process for sustainable manufacturing

    Directory of Open Access Journals (Sweden)

    S. G. Dambhare

    2015-09-01

    Full Text Available There is an increase in awareness about sustainable manufacturing process. Manufacturing industries are backbone of a country’s economy. Although it is important but there is a great concern about consumption of resources and waste creation. The primary aim of this study was to explore sustainability concern in turning process in an Indian machining industry. The effect of cutting parameters, Speed/Feed/Depth of Cut, the machining environment, Dry/MQL/Wet, and the type of cutting tool on sustainability factors under study were observed. Analysis of Variance (ANOVA was used to analyse the data obtained from experimentation in a small scale machining industry. The process is modelled mathematically using response surface methodology (RSM.The economic and environmental aspect like surface roughness, material removal rate and energy consumption were considered as sustainability factors. The model helps to understand the effect of the cutting parameters and conditions on surface finish, energy consumption, and material removal rate. The process was optimized for minimum power consumption considering environmental concern as prime importance. Studies suggest that the cutting environment and tool type influenced on the power consumption during turning process. Extended form of the proposed model could be useful to predict the environmental impact due to machining process, which would bring environmental concern into conventional machining.

  2. Energy-Based Analysis of Ultrasonically Assisted Turning

    Directory of Open Access Journals (Sweden)

    G.A. Volkov

    2011-01-01

    Full Text Available The process of ultrasonically-assisted turning (UAT is a superposition of vibration of a cutting tool on its standard movement in conventional turning (CT. The former technique has several advantages compared with the latter, one of the main being a significant decrease in the level of cutting forces. In this paper the effects observed in UAT are analysed employing ideas of dynamic fracture mechanics. The active stage of loading duration depends heavily on ultrasonic frequency and the cutting speed; he application of the fracture criterion based on the notion of incubation time makes it possible to calculate a dependence of this duration on its threshold amplitude. An estimation of energy, necessary to create a threshold pulse in the material, is made by solving the contact Hertz problem. The obtained time dependence of energy has a marked minimum. Thus, the existence of energy-efficient loading duration is demonstrated. This explains the decrease in the cutting force resulting from superimposed ultrasonic vibration. The obtained results are in agreement with experiments on ultrasonic assisted machining of aluminium and Inconel 718 alloy.

  3. Beyond Cultural History? The Material Turn, Praxiography, and Body History

    Directory of Open Access Journals (Sweden)

    Iris Clever

    2014-10-01

    Full Text Available The body came to be taken seriously as a topic of cultural history during the “corporeal” or “bodily” turn in the 1980s and 1990s. Soon, however, critique was raised against these studies’ conceptualization of the body as discursively shaped and socially disciplined: individual bodily agency and feeling were felt to be absent in the idea of the material body. This article critically analyzes new approaches in the field of body history, particularly the so-called “material turn”. It argues that the material turn, especially in the guise of praxiography, has a lot to offer historians of the body, such as more attention to material practices, to different kinds of actors and a more open eye to encounters. Potential problems of praxiographical analyses of the body in history include the complicated relationship between discourses and practices and the neglect of the political and feminist potential of deconstructive discourse analyses. However, a focus on the relationship between practices of knowledge production and the representation of the body may also provide new ways of opening up historical power relations.

  4. SURFACE INTEGRITY EVALUATION OF TURNING WITH AUTO-ROTATING TOOL

    Directory of Open Access Journals (Sweden)

    Jozef Struharnansky

    2016-09-01

    Full Text Available The technical practice requirements comes to have increased demands on higher productivity, speed and quality of the machining process of various materials. Hard to machine materials, whose machining led to the development of turning with rotating cutting edge are not an exception. The machining process of auto-rotating tool is more complicated than the conventional process of turning, especially for the process of reshaping cutting layers into chips. There is a significant load in the system, that may affect the life of the cutting edge of the tool as well as the whole system and also in the final extent of the qualitative parameters of the workpiece (product / product. The article specifies the knowledge and findings of measurement in machining material 100Cr6 with an auto-rotating tool. The measurements were conducted to evaluate the integrity of the surface (roughness of the workpiece to the impacts of cutting conditions, in particular the feed and the cutting edge inclination. It also analyzes the presence (size, character, action of residual stresses concentrated in the surface layers of the workpiece by changing the cutting conditions.

  5. Development of a Low Cost MQL Setup for Turning Operations

    Directory of Open Access Journals (Sweden)

    Islam Sumaiya

    2017-01-01

    Full Text Available In this study, the effect of MQL application on the tool wear, surface roughness and chip formation in turning Aluminum alloy 6061 is investigated. Experiments were carried out by plain turning of an Aluminum bar with varying depth of cut, cutting speeds (spindle speed and cutting environments (Dry, Wet and MQL. A newly designed, cost efficient and portable MQL setup was developed for this study. For each experimental trial, five passes were carried out in order to promote the formation of tool wear. After each pass, the tool surface was examined under a microscope and the surface roughness was measured using a stylus based surface tester. The extent of tool wear from each pass is measured by using ImageJ software. Chips were collected after the five passes and were physically examined. The newly designed MQL delivery system was successful in delivering a fine mist of lubricant at the cutting point. MQL lubrication provided lower surface roughness and tool wear values compared to wet and dry conditions due to effective temperature reduction and improved lubrication penetration of cutting zones, as well as better chip flushing. Chip formed under MQL conditions had reduced chip thickness due to reduced temperatures. MQL was found to have the greatest positive impact on tool wear and surface roughness parameters based on ANOVA results.

  6. NetTurnP – Neural Network Prediction of Beta-turns by Use of Evolutionary Information and Predicted Protein Sequence Features

    DEFF Research Database (Denmark)

    Petersen, Bent; Lundegaard, Claus; Petersen, Thomas Nordahl

    2010-01-01

    is the highest reported performance on a two-class prediction of β-turn and not-β-turn. Furthermore NetTurnP shows improved performance on some of the specific β-turn types. In the present work, neural network methods have been trained to predict β-turn or not and individual β-turn types from the primary amino......β-turns are the most common type of non-repetitive structures, and constitute on average 25% of the amino acids in proteins. The formation of β-turns plays an important role in protein folding, protein stability and molecular recognition processes. In this work we present the neural network method...... NetTurnP, for prediction of two-class β-turns and prediction of the individual β-turn types, by use of evolutionary information and predicted protein sequence features. It has been evaluated against a commonly used dataset BT426, and achieves a Matthews correlation coefficient of 0.50, which...

  7. The management of turn transition in signed interaction through the lens of overlaps

    OpenAIRE

    Simone eGirard-Groeber

    2015-01-01

    There have been relatively few studies on sign language interaction carried out within the framework of conversation analysis (CA). Therefore, questions remain open about how the basic building blocks of social interaction such as turn, turn construction unit (TCU) and turn transition relevance place (TRP) can be understood and analysed in sign language interaction. Recent studies have shown that signers regularly fine-tune their turn-beginnings to potential completion points of turns (De Vos...

  8. Super paramagnetic core-shells anchored onto silica grafted with C8/NH2nano-particles for ultrasound-assisted magnetic solid phase extraction of imipramine and desipramine from plasma.

    Science.gov (United States)

    Ahmadi, Farhad; Mahmoudi-Yamchi, Tahereh; Azizian, Homa

    2018-03-01

    In current work the Fe 3 O 4 magnetic nano-particles anchored to core-shells of SiO 2 which grafted by C 8 /NH 2 dual mixed groups, have been synthesized. The magnetic nano-particles were characterized by scanning electron microscopy, X-ray diffraction spectroscopy, and zeta-potential reader. The resulted nano-particles have spherical structure with diameters in the range of 105 to 110 nm. A magnetic solid phase extraction method was developed for extraction of imipramine and desipramine from human plasma samples under ultrasonic conditions by using of prepared NPs as sorbent. The MNPs were dispersion in plasma under sonicated conditions, accumulated by an external magnetic field and washed with Briton-Robinson buffer-acetonitrile solution (0.05 mol l -1 , pH = 5, 10%V/V). The drugs were removed by methanol and quantified by gas chromatography. The calibration curves (correlation coefficient > 0.99) for IMP and DES were linear in the concentration range of 0.005 to 5 and 0.01 to 4 μg ml -1 , respectively. The LOD, LOQ, intra and inter-day precision values were measured too. The proposed Fe 3 O 4 /SiO 2 /C 8 /NH 2 MNPs could be applied for 3.0 times. Copyright © 2018. Published by Elsevier B.V.

  9. Pharmacokinetic (PK) drug interaction studies of cabozantinib: Effect of CYP3A inducer rifampin and inhibitor ketoconazole on cabozantinib plasma PK and effect of cabozantinib on CYP2C8 probe substrate rosiglitazone plasma PK.

    Science.gov (United States)

    Nguyen, Linh; Holland, Jaymes; Miles, Dale; Engel, Caroline; Benrimoh, Natacha; O'Reilly, Terry; Lacy, Steven

    2015-09-01

    Cabozantinib is a small-molecule tyrosine kinase inhibitor that has been approved for the treatment of patients with progressive, metastatic medullary thyroid cancer. In vitro data indicate that (1) cytochrome P450 (CYP) 3A4 is the primary CYP isoenzyme involved in the metabolism of cabozantinib, and (2) CYP2C8 is the CYP isoenzyme most potently inhibited by cabozantinib with potential for in vivo inhibition at clinically relevant plasma exposures. Pharmacokinetic (PK) drug-drug interactions (DDIs) were evaluated clinically between cabozantinib and (1) a CYP3A inducer (rifampin) in healthy volunteers, (2) a CYP3A inhibitor (ketoconazole) in healthy volunteers, and (3) a CYP2C8 substrate (rosiglitazone) in patients with solid tumors. Compared with cabozantinib given alone, coadministration with rifampin resulted in a 4.3-fold higher plasma clearance (CL/F) of cabozantinib and a 77% decrease in cabozantinib plasma AUC0-inf , whereas coadministration with ketoconazole decreased cabozantinib CL/F by 29% and increased cabozantinib AUC0-inf by 38%. Chronic coadministration with cabozantinib resulted in no significant effect on rosiglitazone plasma Cmax , AUC0-24 , or AUC0-inf . In summary, chronic use of strong CYP3A inducers and inhibitors should be avoided when cabozantinib is administered, and cabozantinib at clinically relevant exposures is not anticipated to markedly affect the PK of concomitant medications via CYP enzyme inhibition. © 2015, The American College of Clinical Pharmacology.

  10. The correlations of the electronic structure and film growth of 2,7-diocty[1]benzothieno[3,2-b]benzothiophene (C8-BTBT) on SiO2.

    Science.gov (United States)

    Lyu, Lu; Niu, Dongmei; Xie, Haipeng; Zhao, Yuan; Cao, Ningtong; Zhang, Hong; Zhang, Yuhe; Liu, Peng; Gao, Yongli

    2017-01-04

    Combining ultraviolet photoemission spectroscopy (UPS), X-ray photoemission spectroscopy (XPS), atomic force microscopy (AFM) and small angle X-ray diffraction (SAXD) measurements, we perform a systematic investigation on the correlations of the electronic structure, film growth and molecular orientation of 2,7-diocty[1]benzothieno[3,2-b]benzothiophene (C8-BTBT) on silicon oxide (SiO2). AFM analysis reveals a phase transition of disorderedly oriented molecules in clusters in thinner films to highly ordered standing-up molecules in islands in thicker films. SAXD peaks consistently support the standing-up configuration in islands. The increasing ordering of the molecular orientation with film thickness contributes to the changing of the shape and lowering of the leading edge of the highest occupied molecular orbital (HOMO). The end methyl of the highly ordered standing molecules forms an outward pointing dipole layer which makes the work function (WF) decrease with increasing thickness. The downward shift of the HOMO and a decrease of WF result in unconventional downward band bending and decreased ionization potential (IP). The correlations of the orientation ordering of molecules, film growth and interface electronic structures provide a useful design strategy to improve the performance of C8-BTBT thin film based field effect transistors.

  11. NetTurnP--neural network prediction of beta-turns by use of evolutionary information and predicted protein sequence features.

    Directory of Open Access Journals (Sweden)

    Bent Petersen

    Full Text Available UNLABELLED: β-turns are the most common type of non-repetitive structures, and constitute on average 25% of the amino acids in proteins. The formation of β-turns plays an important role in protein folding, protein stability and molecular recognition processes. In this work we present the neural network method NetTurnP, for prediction of two-class β-turns and prediction of the individual β-turn types, by use of evolutionary information and predicted protein sequence features. It has been evaluated against a commonly used dataset BT426, and achieves a Matthews correlation coefficient of 0.50, which is the highest reported performance on a two-class prediction of β-turn and not-β-turn. Furthermore NetTurnP shows improved performance on some of the specific β-turn types. In the present work, neural network methods have been trained to predict β-turn or not and individual β-turn types from the primary amino acid sequence. The individual β-turn types I, I', II, II', VIII, VIa1, VIa2, VIba and IV have been predicted based on classifications by PROMOTIF, and the two-class prediction of β-turn or not is a superset comprised of all β-turn types. The performance is evaluated using a golden set of non-homologous sequences known as BT426. Our two-class prediction method achieves a performance of: MCC=0.50, Qtotal=82.1%, sensitivity=75.6%, PPV=68.8% and AUC=0.864. We have compared our performance to eleven other prediction methods that obtain Matthews correlation coefficients in the range of 0.17-0.47. For the type specific β-turn predictions, only type I and II can be predicted with reasonable Matthews correlation coefficients, where we obtain performance values of 0.36 and 0.31, respectively. CONCLUSION: The NetTurnP method has been implemented as a webserver, which is freely available at http://www.cbs.dtu.dk/services/NetTurnP/. NetTurnP is the only available webserver that allows submission of multiple sequences.

  12. Chip breaking for an automated accurate turning system

    Energy Technology Data Exchange (ETDEWEB)

    Burnham, M.W. (BDM Corp., Albuquerque, NM (USA)); Abbatiello, L.A. (Oak Ridge Y-12 Plant, TN (USA))

    1988-01-01

    Based upon a survey of chip breakup information, the various methods have been evaluated for application to automated accurate turning systems. Many chip breaking methods work well on shafts or cylinders but fail to break chips for an entire inside or outside contouring cut. Many metals produce straight or snarled chip forms at small depths of cut, feed rates, or moderate surface speeds. These chip forms can be a cause of workpiece and tool damage. Such forms also interfere with on-machine gaging, part transfer, and tool change. Often the chip wraps around the tool holder and is difficult to remove even in manual operation. Computer analysis now makes it possible to get the most of each types of chip breaking system. Reliable ship breaking is urgently needed for automated systems, especially those operating in an unmanned mode. 83 refs., 10 figs., 2 tabs.

  13. Chip breaking and control for a precision automated turning system

    Energy Technology Data Exchange (ETDEWEB)

    Burnham, M.W. (BDM International, Inc., McLean, VA (USA)); Abbatiello, L.A. (Martin Marietta Energy Systems, Inc., Oak Ridge, TN (USA))

    1990-01-01

    Chip breaking and control is essential to automatic operation of precision turning systems. Failure to transfer parts and system jams can occur if chip fragments are not continuously removed. Surface damage and tool breakage also result from chips that are permitted to wrap around the tool. Also, with increasing environmental concerns, chip handling and recycling are becoming major issues in manufacturing. New information on a variety of mechanisms for breaking chips and methods for removal from the system are discussed. Some of the chip breaking methods are evaluated for the range of cutting in which they are effective. Chip curl and chip breaking analyzed carefully by Nakayama and others is expanded to more fully understand the ways in which chips can be broken. 23 figs.

  14. The Digital Turn in the French Audiovisual Model

    Directory of Open Access Journals (Sweden)

    Olivier Alexandre

    2016-07-01

    Full Text Available This article deals with the digital turn in the French audiovisual model. An organizational and legal system has evolved with changing technology and economic forces over the past thirty years. The high-income television industry served as the key element during the 1980s to compensate for a shifting value economy from movie theaters to domestic screens and personal devices. However, the growing competition in the TV sector and the rise of tech companies have initiated a disruption process. A challenged French conception copyright, the weakened position of TV channels and the scaling of content market all now call into question the sustainability of the French model in a digital era.

  15. Stability Analysis of Radial Turning Process for Superalloys

    Science.gov (United States)

    Jiménez, Alberto; Boto, Fernando; Irigoien, Itziar; Sierra, Basilio; Suarez, Alfredo

    2017-09-01

    Stability detection in machining processes is an essential component for the design of efficient machining processes. Automatic methods are able to determine when instability is happening and prevent possible machine failures. In this work a variety of methods are proposed for detecting stability anomalies based on the measured forces in the radial turning process of superalloys. Two different methods are proposed to determine instabilities. Each one is tested on real data obtained in the machining of Waspalloy, Haynes 282 and Inconel 718. Experimental data, in both Conventional and High Pressure Coolant (HPC) environments, are set in four different states depending on materials grain size and Hardness (LGA, LGS, SGA and SGS). Results reveal that PCA method is useful for visualization of the process and detection of anomalies in online processes.

  16. The Turn to Precarity in Twenty-First Century Fiction

    Directory of Open Access Journals (Sweden)

    Morrison Jago

    2014-01-01

    Full Text Available Recent years have seen several attempts by writers and critics to understand the changed sensibility in post-9/11 fiction through a variety of new -isms. This essay explores this cultural shift in a different way, finding a ‘turn to precarity’ in twenty-first century fiction characterised by a renewal of interest in the flow and foreclosure of affect, the resurgence of questions about vulnerability and our relationships to the other, and a heightened awareness of the social dynamics of seeing. The essay draws these tendencies together via the work of Judith Butler in Frames of War, in an analysis of Trezza Azzopardi’s quasi-biographical study of precarious life, Remember Me.

  17. Level crossings and turning points of random hyperbolic polynomials

    Directory of Open Access Journals (Sweden)

    K. Farahmand

    1999-01-01

    Full Text Available In this paper, we show that the asymptotic estimate for the expected number of K-level crossings of a random hyperbolic polynomial a1sinhx+a2sinh2x+⋯+ansinhnx, where aj(j=1,2,…,n are independent normally distributed random variables with mean zero and variance one, is (1/πlogn. This result is true for all K independent of x, provided K≡Kn=O(n. It is also shown that the asymptotic estimate of the expected number of turning points for the random polynomial a1coshx+a2cosh2x+⋯+ancoshnx, with aj(j=1,2,…,n as before, is also (1/πlogn.

  18. EXPERIMENTAL VALIDATION OF CUMULATIVE SURFACE LOCATION ERROR FOR TURNING PROCESSES

    Directory of Open Access Journals (Sweden)

    Adam K. Kiss

    2016-02-01

    Full Text Available The aim of this study is to create a mechanical model which is suitable to investigate the surface quality in turning processes, based on the Cumulative Surface Location Error (CSLE, which describes the series of the consecutive Surface Location Errors (SLE in roughing operations. In the established model, the investigated CSLE depends on the currently and the previously resulted SLE by means of the variation of the width of cut. The phenomenon of the system can be described as an implicit discrete map. The stationary Surface Location Error and its bifurcations were analysed and flip-type bifurcation was observed for CSLE. Experimental verification of the theoretical results was carried out.

  19. Forecasting Macedonian Business Cycle Turning Points Using Qual Var Model

    Directory of Open Access Journals (Sweden)

    Petrovska Magdalena

    2016-09-01

    Full Text Available This paper aims at assessing the usefulness of leading indicators in business cycle research and forecast. Initially we test the predictive power of the economic sentiment indicator (ESI within a static probit model as a leading indicator, commonly perceived to be able to provide a reliable summary of the current economic conditions. We further proceed analyzing how well an extended set of indicators performs in forecasting turning points of the Macedonian business cycle by employing the Qual VAR approach of Dueker (2005. In continuation, we evaluate the quality of the selected indicators in pseudo-out-of-sample context. The results show that the use of survey-based indicators as a complement to macroeconomic data work satisfactory well in capturing the business cycle developments in Macedonia.

  20. Wittgenstein and the linguistic turn in social theory

    DEFF Research Database (Denmark)

    Hermansen, Jens Christian

    Historically, the influence of philosopher Peter Winch on the readings of Wittgenstein in the social sciences has been enormous. Though this paper deals mainly with what Winch took to be the implications for the social sciences of Wittgenstein's late philosophy as well as the later critique...... of Winch in social theory, the wider and more recent influence of Wittgenstein in areas such as technology and science studies, social theory, feminist and gender studies and conversation and discourse analysis is also considered. Historically, the readings of Wittgenstein in the social sciences have taken......) and (c) language is an inherently social phenomenon (the social thesis). What the readings of Wittgenstein have disagreed on is what these theses involve and to which extent the social sciences ought to buy into them. According to what I shall call the critical turn i.e. the orthodox critique...

  1. Adenosine induces growth-cone turning of sensory neurons.

    Science.gov (United States)

    Grau, Benjamin; Eilert, John-Christian; Munck, Sebastian; Harz, Hartmann

    2008-12-01

    The formation of appropriate connections between neurons and their specific targets is an essential step during development and repair of the nervous system. Growth cones are located at the leading edges of the growing neurites and respond to environmental cues in order to be guided to their final targets. Directional information can be coded by concentration gradients of substrate-bound or diffusible-guidance molecules. Here we show that concentration gradients of adenosine stimulate growth cones of sensory neurons (dorsal root ganglia) from chicken embryos to turn towards the adenosine source. This response is mediated by adenosine receptors. The subsequent signal transduction process involves cAMP. It may be speculated that the in vivo function of this response is concerned with the formation or the repair and regeneration of the peripheral nervous system.

  2. Multi-turn tracking of collision products at the LHC

    CERN Document Server

    Marsili, Aurelien; Cerutti, Francesco; Esposito, Luigi Salvatore; Redaelli, Stefano

    2014-01-01

    The luminosity expected at the interaction points in LHC at 7 TeV will be unprecedented, up to 1034 cm-2 s-1. Part of the debris produced by the collisions is lost locally immediately downstream the Interaction Point (IP), in the matching section and dispersion suppressor. In this paper, the dynamics of collision debris protons is discussed. First, the loss distributions close to the collision points, simulated with two codes—SixTrack and FLUKA — are compared for different layout configurations. Then, SixTrack is used to simulate the fraction of protons that have undergone inelastic interactions with smaller energy and and betatron offsets, which could travel for several turns around the ring and might be lost in other collimation insertions. A preliminary comparison is made between theresulting loss distribution and measurements.

  3. What turns assistive into restorative brain-machine interfaces?

    Directory of Open Access Journals (Sweden)

    Alireza Gharabaghi

    2016-10-01

    Full Text Available Brain-machine interfaces (BMI may support motor impaired patients during activities of daily living by controlling external devices such as prostheses (assistive BMI. Moreover, BMIs are applied in conjunction with robotic orthoses for rehabilitation of lost motor function via neurofeedback training (restorative BMI. Using assistive BMI in a rehabilitation context does not automatically turn them into restorative devices. This perspective article suggests key features of restorative BMI and provides the supporting evidence:In summary, BMI may be referred to as restorative tools when demonstrating subsequently (i operant learning and progressive evolution of specific brain states/dynamics, (ii correlated modulations of functional networks related to the therapeutic goal, (iii subsequent improvement in a specific task, and (iv an explicit correlation between the modulated brain dynamics and the achieved behavioral gains. Such findings would provide the rationale for translating BMI-based interventions into clinical settings for reinforcement learning and motor rehabilitation following stroke.

  4. Turning the Ship: The Transformation of DESY, 1993-2009

    Science.gov (United States)

    Heinze, Thomas; Hallonsten, Olof; Heinecke, Steffi

    2017-09-01

    This article chronicles the most recent history of the Deutsches Elektronen-Synchrotron (DESY) located in Hamburg, Germany, with particular emphasis on how this national laboratory founded for accelerator-based particle physics shifted its research program toward multi-disciplinary photon science. Synchrotron radiation became DESY's central experimental research program through a series of changes in its organizational, scientific, and infrastructural setup and the science policy context. Furthermore, the turn toward photon science is part of a broader transformation in the late twentieth century in which nuclear and particle physics, once the dominating fields in national and international science budgets, gave way to increasing investment in the materials sciences and life sciences. Synchrotron radiation research took a lead position on the experimental side of these growing fields and became a new form of big science, generously funded by governments and with user communities expanding across both academia and industry.

  5. Refugees and Europe: a dilemma or a turning point?

    Directory of Open Access Journals (Sweden)

    Helgard Mahrdt

    2015-04-01

    Full Text Available Europe is facing a wave of refugees and migrants. To solve the many inherent problems is primarily a practical political task. However, there are existential experiences, democratic values, human attitudes, and political principles involved, and I am going to look particularly to the following three aspects of the refugee crisis, 1 the existential (I refer to the philosopher Martin Heidegger and to the political thinker Hannah Arendt, 2 the political (I turn to the EU’s steps for a common refugee policy, and 3 the legal (I refer to Immanuel Kant’s notion of hospitality and Seyla Benhabib’s notes on Human Rights. Finally, I will make a concluding remark on education’s task (I refer to Hannah Arendt’s and Aristotle’s notion of philia.

  6. STABILITY ANALYSIS OF RADIAL TURNING PROCESS FOR SUPERALLOYS

    Directory of Open Access Journals (Sweden)

    Alberto JIMÉNEZ

    2017-07-01

    Full Text Available Stability detection in machining processes is an essential component for the design of efficient machining processes. Automatic methods are able to determine when instability is happening and prevent possible machine failures. In this work a variety of methods are proposed for detecting stability anomalies based on the measured forces in the radial turning process of superalloys. Two different methods are proposed to determine instabilities. Each one is tested on real data obtained in the machining of Waspalloy, Haynes 282 and Inconel 718. Experimental data, in both Conventional and High Pressure Coolant (HPC environments, are set in four different states depending on materials grain size and Hard-ness (LGA, LGS, SGA and SGS. Results reveal that PCA method is useful for visualization of the process and detection of anomalies in online processes.

  7. The Illiberal Turn or Swerve in Central Europe?

    Directory of Open Access Journals (Sweden)

    Lenka Bustikova

    2017-12-01

    Full Text Available Scholars are coming to terms with the fact that something is rotten in the new democracies of Central Europe. The corrosion has multiple symptoms: declining trust in democratic institutions, emboldened uncivil society, the rise of oligarchs and populists as political leaders, assaults on an independent judiciary, the colonization of public administration by political proxies, increased political control over media, civic apathy, nationalistic contestation and Russian meddling. These processes signal that the liberal-democratic project in the so-called Visegrad Four (the Czech Republic, Hungary, Poland and Slovakia has been either stalled, diverted or reversed. This article investigates the “illiberal turn” in the Visegrad Four (V4 countries. It develops an analytical distinction between illiberal “turns” and “swerves”, with the former representing more permanent political changes, and offers evidence that Hungary is the only country in the V4 at the brink of a decisive illiberal turn.

  8. Mapping the Glocal Turn: Literature Streams, Scholarship Clusters and Debates

    Directory of Open Access Journals (Sweden)

    Victor Roudometof

    2015-12-01

    Full Text Available Based on a bibliographical survey, this article presents evidence of a silent glocal turn in 21st century academia. Several terms compete for describing the newfound situations of hybridity and fusion in the world, and glocalization is a new term that offers a high level of precision in comparison to other contenders. Three specific clusters of inter-disciplinary scholarship are identified as cutting edge areas of research: the study of consumer culture, the field of urban studies and the study of management and/or organizations. Within these areas, glocalization is employed in varied and often contested ways according to specific research agendas. Glocalization thus has become a contested term. The article identifies and describes three debates that involve contrasting appropriations of glocalization. First, there is a contrast between geographical and social interpretations of glocalization, which in turn are based on contrasting definitions of space (geographical versus social. Second, there is a debate over the extent to which glocalization is sufficiently incorporated into global studies, or whether glocal studies should be defined separately from global studies. Third, there is a contrast between homogenization versus hybridization advocates in cross-cultural management and the social sciences. Although often cast as a conflict between proponents of globalization versus proponents of glocalization, this particular debate might be transcended in favor of more inclusive perspectives that suggest a “both/end” solution over an “either/or” interpretation of the opposing views. Glocalization is a recent addition to the vocabulary of 21st century humanities and social sciences. Its employment is also part of a broader wave of interest in the glocal that is not contained within these fields but, rather, extends further into information-communication technology (ICT, medicine and environmental science. To mention one such example, it is not

  9. Turning the Ship: The Transformation of DESY, 1993-2009

    Science.gov (United States)

    Heinze, Thomas; Hallonsten, Olof; Heinecke, Steffi

    2017-12-01

    This article chronicles the most recent history of the Deutsches Elektronen-Synchrotron (DESY) located in Hamburg, Germany, with particular emphasis on how this national laboratory founded for accelerator-based particle physics shifted its research program toward multi-disciplinary photon science. Synchrotron radiation became DESY's central experimental research program through a series of changes in its organizational, scientific, and infrastructural setup and the science policy context. Furthermore, the turn toward photon science is part of a broader transformation in the late twentieth century in which nuclear and particle physics, once the dominating fields in national and international science budgets, gave way to increasing investment in the materials sciences and life sciences. Synchrotron radiation research took a lead position on the experimental side of these growing fields and became a new form of big science, generously funded by governments and with user communities expanding across both academia and industry.

  10. Turning the LHC ring into a new physics search machine

    Science.gov (United States)

    Orava, Risto

    2017-03-01

    The LHC Collider Ring is proposed to be turned into an ultimate automatic search engine for new physics in four consecutive phases: (1) Searches for heavy particles produced in Central Exclusive Process (CEP): pp → p + X + p based on the existing Beam Loss Monitoring (BLM) system of the LHC; (2) Feasibility study of using the LHC Ring as a gravitation wave antenna; (3) Extensions to the current BLM system to facilitate precise registration of the selected CEP proton exit points from the LHC beam vacuum chamber; (4) Integration of the BLM based event tagging system together with the trigger/data acquisition systems of the LHC experiments to facilitate an on-line automatic search machine for the physics of tomorrow.

  11. Turning toward dissonance: lessons from art, music, and literature.

    Science.gov (United States)

    Makowski, Suzana K E; Epstein, Ronald M

    2012-02-01

    Conflict and chaos are prevalent in health care, and perhaps especially in palliative care. Typically, our point of entry into our patients' lives is often at the moment of conflict, discord, or intense suffering. Despite this, little in our formal training as clinicians teaches us how to be present for this suffering. Much has been written about the process of communication with regard to giving bad news, handling family meeting conflicts, and negotiating shifting goals of care, but little has been addressed about how to train the clinician to be present with the dissonance and suffering. In this paper, we explore how music, art, and literature teach us how to stay in moments of tension. In turn, lessons on how to learn to lean into the dissonance of many palliative care encounters are extrapolated. Copyright © 2012 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.

  12. Design and performance of a small precision CNC turning machine

    Energy Technology Data Exchange (ETDEWEB)

    Donaldson, R.R.; Thompson, D.C.

    1986-02-26

    This paper describes the design of a CNC turning machine that is capable of machining workpieces up to 100 mm in diameter with a high contour accuracy and a very low surface roughness. Two nearly identical machines have been built and put into operation using this design, one for serial parts manufacture and the other for research into improving the accuracy of single-point machining; information based on this operational experience is also presented. The first machine has demonstrated an accuracy of 0.1 ..mu..m peak-to-valley on contoured workpieces, while the second machine has produced surface roughnesses of 1 nm rms in flat facing of electroless nickel with a diamond tool.

  13. Het Nationaal Historisch Museum en de emotional turn

    Directory of Open Access Journals (Sweden)

    P. van de Laar

    2009-01-01

    Full Text Available The Dutch National History Museum and the ‘Emotional Turn’Recent discussions about the Dutch National History Museum (NHM should not be restricted to issues put forward by professional historians, be it the importance of a historical canon or nuanced historical debates. Two major, strongly intertwined developments will have to be considered. Firstly, the emotional turn in recent heritage discussions and, secondly, the increasing multi-medialisation of our daily lives. These 21st century developments call for a redefinition of the tasks of a museum for cultural history and a new paradigm in history museums. Traditional collection-driven museums will not be able to satisfy the challenges of the emotional and digital requirements. The NHM should aim to be at the cutting edge of new museum practises.

  14. Turned versus anodised dental implants: a meta-analysis.

    Science.gov (United States)

    Chrcanovic, B R; Albrektsson, T; Wennerberg, A

    2016-09-01

    The aim of this meta-analysis was to test the null hypothesis of no difference in the implant failure rates, marginal bone loss (MBL)and post-operative infection for patients being rehabilitated by turned versus anodised-surface implants, against the alternative hypothesis of a difference. An electronic search without time or language restrictions was undertaken in November 2015. Eligibility criteria included clinical human studies, either randomised or not. Thirty-eight publications were included. The results suggest a risk ratio of 2·82 (95% CI 1·95-4·06, P implants, when compared to anodised-surface implants. Sensitivity analyses showed similar results when only the studies inserting implants in maxillae or mandibles were pooled. There were no statistically significant effects of turned implants on the MBL (mean difference-MD 0·02, 95%CI -0·16-0·20; P = 0·82) in comparison to anodised implants. The results of a meta-regression considering the follow-up period as a covariate suggested an increase of the MD with the increase in the follow-up time (MD increase 0·012 mm year(-1) ), however, without a statistical significance (P = 0·813). Due to lack of satisfactory information, meta-analysis for the outcome 'post-operative infection' was not performed. The results have to be interpreted with caution due to the presence of several confounding factors in the included studies. © 2016 John Wiley & Sons Ltd.

  15. Ramping turn-to-turn loss and magnetization loss of a No-Insulation (RE)Ba2Cu3Ox high temperature superconductor pancake coil

    Science.gov (United States)

    Wang, Y.; Song, H.; Yuan, W.; Jin, Z.; Hong, Z.

    2017-03-01

    This paper is to study ramping turn-to-turn loss and magnetization loss of a no-insulation (NI) high temperature superconductor (HTS) pancake coil wound with (RE)Ba2Cu3Ox (REBCO) conductors. For insulated (INS) HTS coils, a magnetization loss occurs on superconducting layers during a ramping operation. For the NI HTS coil, additional loss is generated by the "bypassing" current on the turn-to-turn metallic contacts, which is called "turn-to-turn loss" in this study. Therefore, the NI coil's ramping loss is much different from that of the INS coil, but few studies have been reported on this aspect. To analyze the ramping losses of NI coils, a numerical method is developed by coupling an equivalent circuit network model and a H-formulation finite element method model. The former model is to calculate NI coil's current distribution and turn-to-turn loss, and the latter model is to calculate the magnetization loss. A test NI pancake coil is wound with REBCO tapes and the reliability of this model is validated by experiments. Then the characteristics of the NI coil's ramping losses are studied using this coupling model. Results show that the turn-to-turn loss is much higher than the magnetization loss. The NI coil's total ramping loss is much higher than that of its insulated counterpart, which has to be considered carefully in the design and operation of NI applications. This paper also discusses the possibility to reduce NI coil's ramping loss by decreasing the ramping rate of power supply or increasing the coil's turn-to-turn resistivity.

  16. Stuck with/in a 'turn': Can we metaphorize better in Science and Technology Studies?

    Science.gov (United States)

    Vasileva, Bistra

    2015-06-01

    This contribution encourages loosening the cast-iron mould of the 'turn' metaphor that the practices of general and ontology-related turn-talking/making in Science and Technology Studies forge and fortify. Could framing novel themes and thinking in terms of 'turn' be as good as fettering? Not specific to the 'ontological turn' or 'turn to ontology', but haunting Science and Technology Studies across the board to signify supposed tidal change, the metaphor warrants dissection. Thus, this commentary expounds four distinct yet not unrelated versions of 'turn'--rotation, change of course/direction, change in general and occasion/opportunity to act--together with the worlds they beget. Then, the operation of these 'turns' in the debates on the 'ontological turn' is pursued. Enactments of the first three modes/moulds of 'turn', all entailing and tainted by the inexorable directedness of change the coupled 'turn to' framing imparts, either debunk or qualify the extent of the professed 'turn', with the effect of betraying its conceptual and methodological offerings. The fourth version, less substitutable with 'turn to' and thus less infected by intransigent directedness, escapes the rigidity that diminishes the value of ontology-minded studies. Clear of either a resolution to the debate or an alternative trope to cure the maladies of 'turn', the conclusion wishes to open space for pondering how to metaphorize more consciously and judiciously evolution and innovation in Science and Technology Studies.

  17. Prediction of Turn-Ends Based on Anticipation of Upcoming Words

    Science.gov (United States)

    Magyari, Lilla; de Ruiter, J. P.

    2012-01-01

    During conversation listeners have to perform several tasks simultaneously. They have to comprehend their interlocutor’s turn, while also having to prepare their own next turn. Moreover, a careful analysis of the timing of natural conversation reveals that next speakers also time their turns very precisely. This is possible only if listeners can predict accurately when the speaker’s turn is going to end. But how are people able to predict when a turn-ends? We propose that people know when a turn-ends, because they know how it ends. We conducted a gating study to examine if better turn-end predictions coincide with more accurate anticipation of the last words of a turn. We used turns from an earlier button-press experiment where people had to press a button exactly when a turn-ended. We show that the proportion of correct guesses in our experiment is higher when a turn’s end was estimated better in time in the button-press experiment. When people were too late in their anticipation in the button-press experiment, they also anticipated more words in our gating study. We conclude that people made predictions in advance about the upcoming content of a turn and used this prediction to estimate the duration of the turn. We suggest an economical model of turn-end anticipation that is based on anticipation of words and syntactic frames in comprehension. PMID:23112776

  18. Muscular Control of Turning and Maneuvering in Jellyfish Bells

    Science.gov (United States)

    Hoover, Alexander; Miller, Laura; Griffith, Boyce

    2014-11-01

    Jellyfish represent one of the earliest and simplest examples of swimming by a macroscopic organism. Contractions of an elastic bell that expels water are driven by coronal swimming muscles. The re-expansion of the bell is passively driven by stored elastic energy. A current question in jellyfish propulsion is how the underlying neuromuscular organization of their bell allows for maneuvering. Using an immersed boundary framework, we will examine the mechanics of swimming by incorporating material models that are informed by the musculature present in jellyfish into a model of the elastic jellyfish bell in three dimensions. The fully-coupled fluid structure interaction problem is solved using an adaptive and parallelized version of the immersed boundary method (IBAMR). We then use this model to understand how variability in the muscular activation patterns allows for complicated swimming behavior, such as steering. We will compare the results of the simulations with the actual turning maneuvers of several species of jellyfish. Numerical flow fields will also be compared to those produced by actual jellyfish using particle image velocimetry (PIV).

  19. Strangulated Femoral Hernia Turned to Be Peritoneal Cyst

    Directory of Open Access Journals (Sweden)

    Dionysios Dellaportas

    2012-01-01

    Full Text Available Introduction. A peritoneal inclusion cyst is a very rare mesenteric cyst of mesothelial origin usually asymptomatic. A rare case of an 82-year-old white Caucasian female with a femoral hernia containing a large peritoneal inclusion cyst, mimicking strangulated hernia, is presented herein. Case Presentation. The patient was admitted to our hospital suffering from a palpable groin mass on the right, which became painful and caused great discomfort for the last hours. Physical examination revealed a tender and tense, irreducible groin mass. An inguinal operative approach was selected and the mass was found protruding through the femoral ring. After careful dissection it turned out to be a large unilocular cyst, containing serous fluid, probably originating from the peritoneum. McVay procedure was used to reapproximate the femoral ring. Histologic examination showed a peritoneal inclusion cyst. Discussion. Peritoneal inclusion cysts are usually asymptomatic but occasionally present with various, nonspecific symptoms according to their size. Our case highlights that high index of clinical suspicion and careful exploration during repair of a hernia is mandatory in order to reach the correct diagnosis about hernia’s contents.

  20. An industrial tool wear monitoring system for interrupted turning

    Science.gov (United States)

    Scheffer, C.; Heyns, P. S.

    2004-09-01

    An effective wear-monitoring system for machine tool inserts could yield significant cost savings for manufacturers. Over the years, various methods have been proposed to achieve tool condition monitoring (TCM), and recently sensor-based approaches for indirectly estimating tool wear have become highly popular. One difficulty with collecting sensory information from machine tools is that the signal-to-noise ratio of useful information about the tool wear is extremely poor. This problem can be overcome by using advanced signal-processing methods and also by fusing the information obtained from numerous sensors into a single modelling or decision-making scheme such as neural networks (NNs). Neural networks are known for their capacity to solve problems effectively in cases where theoretical/analytical models cannot be established. Furthermore, NNs can handle noisy and incomplete data such as that typically obtained from machining operations. Although numerous authors have proposed the NN approach for TCM, various problems still hamper a practical method of applying the technique for industrial use. This paper proposes a technique which should overcome these difficulties. A cost-effective and reliable tool condition monitoring system (TCMS) was developed, utilising the advantages of NNs for a typical industrial machining operation. The operation considered is interrupted turning (facing and boring) of Aluminium alloy components for the automotive industry. The development and implementation of various hardware and software components for the proposed technique are described in this paper. The main advantages of the technique are its accuracy, reliability and cost-effectiveness.

  1. The Democratic Turn in the Secularism-Religion Debate

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    Diego Bermejo

    2017-11-01

    Full Text Available The revival of the religion in the new context of a global world-society, which is as modern as religious, doesn´t happen only as a sociological result of the dismantling of the postcolonial world –which denies the secularist forecast of the religion decline and provides the pluralism phenomenon with an unthought-of ethical and political complexity and virtuality– , but as a result of the modern reason crisis too, that makes reason rationally unable to justify political life relying on a rationalist ethical monism. The rationalist last foundation crisis affects as much the fundamentalist religious claims –which pretend to interpret the so called “religion resurgence or religion revival” in a “postsecular society” in a rapidly triumphal way, as the secularist claims which pretend to deny the religion any ethical and political virtuality in the public sphere. The democratic turn, antiauthoritarian and antidogmatic, coherently demanded within the context of the modern reason crisis by three well-known representatives of the postmetaphysical, hermeneutical and pragmatist philosophy, such as Vattimo, Habermas and Rorty, replaces the debate between secularism and religion on the basis of true questions with the other on the basis of solidarity questions.

  2. The Development of Philosophy and Its Fundamental Informational Turn

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    Kun Wu

    2015-10-01

    Full Text Available Through the rescientification of philosophy and the philosophization of science, an entirely new concept of science and philosophy as part of general human knowledge is developing. In this concept, science and philosophy become intrinsically integrated and unified, forming dynamic feedback-loops which lead to further mutual transformation and integration. This development is taking place in the face of two kinds of dogmatism: one is naturalistic dogmatism, the other the dogmatism of consciousness philosophy. These two kinds of dogmatism are an inevitable consequence of the method of segmentation of the field of existence in traditional philosophy namely: existence = matter + Spirit (mind. The development of the Science and Philosophy of Information reveals a world of information-by-itself lying between the worlds of matter and Sprit, and re-interprets the essence of the Spiritual world in the sense of prior information activities. Accordingly, we can describe the movements from matter to Spirit, and from Spirit to matter in these activities as processes, eliminating their dualistic separation, and achieve an informational turn in philosophy, the first truly fundamental one.

  3. Complement in disease: a defence system turning offensive.

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    Ricklin, Daniel; Reis, Edimara S; Lambris, John D

    2016-07-01

    Although the complement system is primarily perceived as a host defence system, a more versatile, yet potentially more harmful side of this innate immune pathway as an inflammatory mediator also exists. The activities that define the ability of the complement system to control microbial threats and eliminate cellular debris - such as sensing molecular danger patterns, generating immediate effectors, and extensively coordinating with other defence pathways - can quickly turn complement from a defence system to an aggressor that drives immune and inflammatory diseases. These host-offensive actions become more pronounced with age and are exacerbated by a variety of genetic factors and autoimmune responses. Complement can also be activated inappropriately, for example in response to biomaterials or transplants. A wealth of research over the past two decades has led to an increasingly finely tuned understanding of complement activation, identified tipping points between physiological and pathological behaviour, and revealed avenues for therapeutic intervention. This Review summarizes our current view of the key activating, regulatory, and effector mechanisms of the complement system, highlighting important crosstalk connections, and, with an emphasis on kidney disease and transplantation, discusses the involvement of complement in clinical conditions and promising therapeutic approaches.

  4. AE Monitoring of Diamond Turned Rapidly Soldified Aluminium 443

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    Onwuka, G.; Abou-El-Hossein, K.; Mkoko, Z.

    2017-05-01

    The fast replacement of conventional aluminium with rapidly solidified aluminium alloys has become a noticeable trend in the current manufacturing industries involved in the production of optics and optical molding inserts. This is as a result of the improved performance and durability of rapidly solidified aluminium alloys when compared to conventional aluminium. Melt spinning process is vital for manufacturing rapidly solidified aluminium alloys like RSA 905, RSA 6061 and RSA 443 which are common in the industries today. RSA 443 is a newly developed alloy with few research findings and huge research potential. There is no available literature focused on monitoring the machining of RSA 443 alloys. In this research, Acoustic Emission sensing technique was applied to monitor the single point diamond turning of RSA 443 on an ultrahigh precision lathe machine. The machining process was carried out after careful selection of feed, speed and depths of cut. The monitoring process was achieved with a high sampling data acquisition system using different tools while concurrent measurement of the surface roughness and tool wear were initiated after covering a total feed distance of 13km. An increasing trend of raw AE spikes and peak to peak signal were observed with an increase in the surface roughness and tool wear values. Hence, acoustic emission sensing technique proves to be an effective monitoring method for the machining of RSA 443 alloy.

  5. The Effects of Structured Turn-Taking on Disfluencies: A Case Study.

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    Winslow, Mary; Guitar, Barry

    1994-01-01

    This study examined the effects of structured conversational turn-taking on disfluencies and speech rate of a boy (age 5) who stuttered, based on dinner-time conversations in the subject's home. Results indicated that disfluencies decreased when structured conversational turn-taking was instituted and increased when turn-taking conditions were not…

  6. Study on Turn-to-turn Short Circuit On一line Monitoring System for Dry一type Ai r一core Reactor

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    GAO Zi-wei

    2017-04-01

    Full Text Available The change of current value caused by turn-to-turn short circuit of dry-type air-core reactor is so little that failure detection is difficult to be carried out. In order to solve this problem,a new on-line monitoring system based on impedance variation of turn-to-turn short circuit is proposed. The numerical method is applied to analyze the variation of equivalent resistance and equivalent reactance when dry-type air-core reactor winding short circuit happens in different places,and the monitoring method based on harmonic analysis method and quasi- synchronization sampling method is analyzed by theory. The hardware system,which takes single-chip microcomputer as the core of data processing and logic control,completes data acquisition of voltage signal and current signal of the reactor. In the respect of software design,the impedance variation will be uploaded to the PC after it has been calculated by using the above monitoring method,and then monitoring of turn-to-turn short circuit fault will be realized. Finally,the design of on-line monitoring system is studied by testing. The research result shows that,the equivalent resistance increases and the equivalent reactance decreases when turn-to-turn short circuit occurs,and the variation of equivalent resistance is more obvious than equivalent reactance. The experiment results prove that this monitoring method is true and the on-line monitoring system is feasible.

  7. Housing the "Other" Half: American Studies' Global Urban Turn

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    David Faflik

    2010-03-01

    Full Text Available

    Over the course of its short lifetime, the discipline of American studies has utilized a series of self-defining metaphors. With each successive paradigm shift in the field, each of these disciplinary figures, in turn, has been found wanting, and so replaced. American studies’ current, if not consensual, metaphor—the “border”—resembles not a few of its predecessors in that it is spatial in nature and effectively doubles as a figuration of the greater nation. The premise of this paper is that the “border,” like the figures that came before it, has outlived its serviceable purpose for a discipline that continues to evolve.

    This essay proposes the global city, or, more accurately, the global slum, as a post-“border” metaphor peculiarly adapted to the principled transnationalism that now defines American studies for many subscribing students and professionals. On the one hand, the urban has become a prevailing demographic fact in this, the new century. Thus, the multiethnic, multinational world metropolis recommends itself as a more-than-metaphor for the dynamic cultural contact that typifies ascendant hemispheric conceptions of the Americas. On the other hand, the figure of the peripheral city similarly, and spatially, evokes the majority “center” and minority “margin” model of American studies that critics would claim inhibits total global integration among the discipline’s geoculturally diverse practitioners, many of whom reside outside the continental United States. This essay conceptually deploys the world city to explore beyond these professional/territorial “borders.” Its three condensed case studies—first, of Gilded Age Manhattan, second, of the modern Turkish metropolis, and third, of a reunified Germany’s ethnic ghetto—constitute a brisk figurative exercise in “marginal” urban migration, wherein resides an alternate model, and metaphor, of American studies praxis today.

  8. The performative turn at Inhotim: installation art and Baudelairean modernity

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    Lauren S. Weingarden

    2013-12-01

    Full Text Available This article explores the participatory turn in installation art as part of a trajectory from Baudelairean modernity to twentyfirst-century postmodernity, as represented at Inhotim, the outdoor contemporary art museum and botanical gardens in Brumadinho, MG. In his 1862 essay “The Painter of ModernLife,” Charles Baudelaire defined modernity as fleeting, transitory and fragmentary. Baudelairean modernity initiated a breakdown of boundaries between art and life and between high art aesthetics and popular culture, which continues in the work of installation artists. In the sites of installation art, the spectator is compelled to extend – rather than complete – the work of art in his/her own time, prior experiential encounters and transformative after thoughts.The shift from the isolated work of art to the experiential one notonly complicates how and where works of art are viewed, but also radicalizes the materials that constitute the work of art – whether those materials are extracted from the quotidian sphere or complex technologies, each undergoes a process of defamiliarization and reactivation to produce the transformative aesthetic experience.The individual installations in Inhotim’s “outdoor museum” engage the spectator in a dynamic/participatory experience with spatial,temporal and material relationships that define the very essence of art’s reciprocity, or contrast with the natural and man-madeworlds. It is the rarefied setting of Inhotim’s botanical gardens that makes the participatory and transformative experience central to the aesthetic encounter with installation art.

  9. Aerodynamic drag modeling of alpine skiers performing giant slalom turns.

    Science.gov (United States)

    Meyer, Frédéric; Le Pelley, David; Borrani, Fabio

    2012-06-01

    Aerodynamic drag plays an important role in performance for athletes practicing sports that involve high-velocity motions. In giant slalom, the skier is continuously changing his/her body posture, and this affects the energy dissipated in aerodynamic drag. It is therefore important to quantify this energy to understand the dynamic behavior of the skier. The aims of this study were to model the aerodynamic drag of alpine skiers in giant slalom simulated conditions and to apply these models in a field experiment to estimate energy dissipated through aerodynamic drag. The aerodynamic characteristics of 15 recreational male and female skiers were measured in a wind tunnel while holding nine different skiing-specific postures. The drag and the frontal area were recorded simultaneously for each posture. Four generalized and two individualized models of the drag coefficient were built, using different sets of parameters. These models were subsequently applied in a field study designed to compare the aerodynamic energy losses between a dynamic and a compact skiing technique. The generalized models estimated aerodynamic drag with an accuracy of between 11.00% and 14.28%, and the individualized models estimated aerodynamic drag with an accuracy between 4.52% and 5.30%. The individualized model used for the field study showed that using a dynamic technique led to 10% more aerodynamic drag energy loss than using a compact technique. The individualized models were capable of discriminating different techniques performed by advanced skiers and seemed more accurate than the generalized models. The models presented here offer a simple yet accurate method to estimate the aerodynamic drag acting upon alpine skiers while rapidly moving through the range of positions typical to turning technique.

  10. Neutrophils Turn Plasma Proteins into Weapons against HIV-1.

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    Cornelia Speth

    Full Text Available As a consequence of innate immune activation granulocytes and macrophages produce hypochlorite/hypochlorous acid (HOCl via secretion of myeloperoxidase (MPO to the outside of the cells, where HOCl immediately reacts with proteins. Most proteins that become altered by this system do not belong to the invading microorganism but to the host. While there is no doubt that the myeloperoxidase system is capable of directly inactivating HIV-1, we hypothesized that it may have an additional indirect mode of action. We show in this article that HOCl is able to chemically alter proteins and thus turn them into Idea-Ps (Idea-P = immune defence-altered protein, potent amyloid-like and SH-groups capturing antiviral weapons against HIV-1. HOCl-altered plasma proteins (Idea-PP have the capacity to bind efficiently and with high affinity to the HIV-1 envelope protein gp120, and to its receptor CD4 as well as to the protein disulfide isomerase (PDI. Idea-PP was able to inhibit viral infection and replication in a cell culture system as shown by reduced number of infected cells and of syncytia, resulting in reduction of viral capsid protein p24 in the culture supernatant. The unmodified plasma protein fraction had no effect. HOCl-altered isolated proteins antithrombin III and human serum albumin, taken as representative examples of the whole pool of plasma proteins, were both able to exert the same activity of binding to gp120 and inhibition of viral proliferation. These data offer an opportunity to improve the understanding of the intricacies of host-pathogen interactions and allow the generation of the following hypothetical scheme: natural immune defense mechanisms generate by posttranslational modification of plasma proteins a potent virucidal weapon that immobilizes the virus as well as inhibits viral fusion and thus entry into the host cells. Furthermore simulation of this mechanism in vitro might provide an interesting new therapeutic approach against

  11. The Timed 180° Turn Test for Assessing People with Hemiplegia from Chronic Stroke

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    Regan L. Robinson

    2018-01-01

    Full Text Available Background. Turning is ubiquitous in activities of daily living. For people with hemiplegia, persistent impairments in strength, balance, and coordination will affect their ability to turn safely. Consequently, turning retraining should be addressed in rehabilitation programs. To measure turning for these individuals, a reliable clinical tool is required. Objective. To investigate (i the intrarater, interrater, and test-retest reliability of the timed 180° turn test; (ii the correlation of the timed 180° turn test with other measures of stroke-specific impairments; and (iii the cut-off time that best discriminates individuals with hemiplegia from chronic stroke and healthy older adults. Methods. 33 individuals with hemiplegia due to chronic stroke and 32 healthy elderly individuals participated in this cross-sectional study. The timed 180° turn test was administered along with other measures of stroke-specific impairment. Results. The timed 180° turn test demonstrated excellent intrarater, interrater, and test-retest reliability in individuals with hemiplegia from chronic stroke. The timed 180° turn test (times significantly correlated with the Fugl-Meyer Assessment of the Lower Extremities (FMA-LE, affected ankle plantar flexion strength, the 5-Times-Sit-To-Stand test, the Berg Balance Scale (BBS, and the Timed Up and Go (TUG test. Conclusion. The timed 180° turn test is a reliable clinical tool to assess the turning ability of subjects with hemiplegia from chronic stroke.

  12. Identification and yields of 1,4-hydroxynitrates formed from the reactions of C8-C16 n-alkanes with OH radicals in the presence of NO(x).

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    Yeh, Geoffrey K; Ziemann, Paul J

    2014-09-25

    A series of C8-C16 n-alkanes were reacted with OH radicals in the presence of NOx in an environmental chamber and particulate 1,4-hydroxynitrate reaction products were collected by filtration, extracted, and analyzed by high-performance liquid chromatography with UV absorption and electron ionization mass spectrometry (HPLC/UV/MS). Observed mass spectral patterns can be explained by using proposed ion fragmentation mechanisms, permitting the identification of each hydroxynitrate isomer. Reversed-phase retention of these compounds was dictated by the length of the longer of two alkyl chains attached to the 1,4-hydroxynitrate subunit. 1,4-Hydroxynitrates were quantified in particles using an authentic analytical standard for calibration, and the results were combined with gas chromatography measurements of the n-alkanes to determine the molar yields. Yields based on analyses of particles increased with increasing carbon number from 0.00 for C8 to an average plateau value of 0.130 ± 0.008 for C14-C16, due primarily to corresponding increases in gas-to-particle partitioning. The value at the plateau, where essentially all 1,4-hydroxynitrates were in particles, was equal to the average total yield of C14-C16 1,4-hydroxynitrates. The average branching ratio for the formation of C14-C16 1,4-hydroxynitrates from the reaction of NO with the corresponding 1,4-hydroxyperoxy radicals was 0.184 ± 0.011. This value is ∼20% higher than the plateau value of 0.15 for reactions of secondary 1,2-hydroxyperoxy radicals and ∼40% lower than the plateau value of 0.29 for reactions of secondary alkyl peroxy radicals, both of which were reported previously. The branching ratios determined here were used with values reported previously to calculate the yields of C7-C18 alkyl nitrates, 1,4-hydroxynitrates, and 1,4-hydroxycarbonyls, the three products formed from the reactions of these n-alkanes.

  13. Perfluoroalkyl Substances, Sex Hormones, and Insulin-like Growth Factor-1 at 6-9 Years of Age: A Cross-Sectional Analysis within the C8 Health Project.

    Science.gov (United States)

    Lopez-Espinosa, Maria-Jose; Mondal, Debapriya; Armstrong, Ben G; Eskenazi, Brenda; Fletcher, Tony

    2016-08-01

    Exposure to some perfluoroalkyl substances (PFAS), such as perfluorohexane sulfonate (PFHxS), perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), and perfluorononanoic acid (PFNA), may alter levels of sex hormones and insulin-like growth factor-1 (IGF-1) in animals. Human studies on this topic are scarce, and none have been conducted in young children. We investigated the relationship between levels of PFAS and estradiol, total testosterone, and IGF-1 in 2,292 children (6-9 years of age) from the C8 Health Project who lived near a chemical plant in the Mid-Ohio Valley (USA) with local contamination from PFOA. Serum samples were collected in 2005-2006 and analyzed for PFAS, sex hormones, and IGF-1. Results from regression models were expressed as the adjusted percentage difference (95% CI) per sex-specific interquartile range (IQR) increment of each PFAS serum concentration. Analyses by PFAS quartiles were also conducted. Median concentrations of PFHxS, PFOA, PFOS, and PFNA were 8, 35, 22, and 1.7 ng/mL in boys and 7, 30, 21, and 1.7 ng/mL in girls. In boys, PFOA concentrations were significantly associated with testosterone levels (-4.9%; 95% CI: -8.7, -0.8%); PFOS with estradiol (-4.0%; 95% CI: -7.7, -0.1%), testosterone (-5.8%; 95% CI: -9.4, -2.0%), and IGF-1 (-5.9%; 95% CI: -8.3, -3.3%); and PFNA with IGF-1 (-3.5%; 95% CI: -6.0, -1.0%). In girls, significant associations were found between PFOS and testosterone (-6.6%; 95% CI: -10.1, -2.8%) and IGF-1 (-5.6%; -8.2, -2.9%); and PFNA and IGF-1 (-3.8%; 95% CI: -6.4, -1.2%). In both sexes, the magnitudes of the associations decreased monotonically across quartiles for both testosterone and IGF-1 in relation to PFOS, and for IGF-1 and PFNA in girls. To our knowledge, this is the first study suggesting that PFAS are associated with lower levels of IGF-1 and sex hormones in young children. Lopez-Espinosa MJ, Mondal D, Armstrong BG, Eskenazi B, Fletcher T. 2016. Perfluoroalkyl substances, sex hormones, and

  14. High speed turning of compacted graphite iron using controlled modulation

    Science.gov (United States)

    Stalbaum, Tyler Paul

    class of industrial machining applications. This study's approach is by series of high speed turning tests of CGI with CBN tools, comparing conventional machining to MAM for similar parameters otherwise, by tool wear measurements and machinability observations.

  15. Latin America: the Right Storm for the Left Turn

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    Victor Lazarevich Jeifets

    2015-12-01

    Full Text Available The article deals with the analysis of the challenges for the Latin American left-wing governments throughout the electoral campaigns of 2014-2015. Up to the moment these electoral campaigns and their results were not researched and analyzed in the scientific literature. However, it was not the only aim of the article. The authors consider necessary to explain how the achievements made by the Left-Wing political forces may affect and determine the general political situation and international panorama of the region. Consequently, the special attention is paid to the analysis of the electoral rallies in some key countries for the Left-Wing block as whole. These countries are Brazil, Uruguay, Chile and Salvador as they represent different patterns of Left-Wing turn in the region. As almost all of them form part of some Latin American subregional integration groups, the authors also make some prospects about the possible shifts in the system of international relations in the region as a consequence of these electoral campaigns. Within the marks of the article the authors analyze possible transformations of South American Common market (MERCOSUR and the Bolivarian Alliance for Americas (ALBA and explain how the results of elections of 2014 would affect the envolvement of some Leftist governments into these integration groups. According to authors’ criteria, the Pirric triumph in Salvador should inevitably put in question the plans of Salvadoran close envolvement into the ALBA. Additionally, the visible weakening of Leftist government in Brazil will bring the redetermining of its relationship with the USA and can also affect Brazil’s leading role in the Mercosur. The authors confront the statistical data and the results of elections with the known facts of political behavior of Left-Wing governments in respect of the economical and political integration and relationship with the USA, China and Russia. The main object of the research was to

  16. ω-Turn: a novel β-turn mimic in globular proteins stabilized by main-chain to side-chain C−H···O interaction.

    Science.gov (United States)

    Dhar, Jesmita; Chakrabarti, Pinak; Saini, Harpreet; Raghava, Gajendra Pal Singh; Kishore, Raghuvansh

    2015-02-01

    Mimicry of structural motifs is a common feature in proteins. The 10-membered hydrogen-bonded ring involving the main-chain C − O in a β-turn can be formed using a side-chain carbonyl group leading to Asx-turn. We show that the N − H component of hydrogen bond can be replaced by a C(γ) -H group in the side chain, culminating in a nonconventional C − H···O interaction. Because of its shape this β-turn mimic is designated as ω-turn, which is found to occur ∼ three times per 100 residues. Three residues (i to i + 2) constitute the turn with the C − H···O interaction occurring between the terminal residues, constraining the torsion angles ϕi + 1, ψi + 1, ϕi + 2 and χ'1(i + 2) (using the interacting C(γ) atom). Based on these angles there are two types of ω-turns, each of which can be further divided into two groups. C(β) -branched side-chains, and Met and Gln have high propensities to occur at i + 2; for the last two residues the carbonyl oxygen may participate in an additional interaction involving the S and amino group, respectively. With Cys occupying the i + 1 position, such turns are found in the metal-binding sites. N-linked glycosylation occurs at the consensus pattern Asn-Xaa-Ser/Thr; with Thr at i + 2, the sequence can adopt the secondary structure of a ω-turn, which may be the recognition site for protein modification. Location between two β-strands is the most common occurrence in protein tertiary structure, and being generally exposed ω-turn may constitute the antigenic determinant site. It is a stable scaffold and may be used in protein engineering and peptide design. © 2014 Wiley Periodicals, Inc.

  17. Synthesis of oligonucleotides containing novel G-clamp analogue with C8-tethered group in phenoxazine ring: Implication to qPCR detection of the low-copy Kemerovo virus dsRNA.

    Science.gov (United States)

    Varizhuk, Anna M; Zatsepin, Timofei S; Golovin, Andrey V; Belyaev, Evgeny S; Kostyukevich, Yury I; Dedkov, Vladimir G; Shipulin, German A; Shpakovski, George V; Aralov, Andrey V

    2017-07-15

    Nowadays modified oligonucleotides are widely used in diagnostics and as novel therapeutics. Introduction of modified or unnatural residues into oligonucleotides allows fine tuning of their binding properties to complementary nucleic acids and leads to improved stability both in vitro and in vivo. Previously it was demonstrated that insertion of phenoxazine nucleotides with various groups in C9-position into oligonucleotides leads to a significant increase of duplex stability with complementary DNA and RNA. Here the synthesis of a novel G-clamp nucleoside analogue (G8AE-clamp) bearing 2-aminoethyl tether at C8-atom is presented. Introduction of such modified residues into oligonucleotides lead to enhanced specificity of duplex formation towards complementary DNA and RNA targets with increased thermal and 3'-exonuclease stability. According to CD-spectroscopy studies G8AE-clamp does not substantially disrupt helix geometry. Primers containing G8AE-clamp demonstrated superior sensitivity in qPCR detection of dsRNA of Kemerovo virus in comparison to native oligonucleotides. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Egg turning behavior and incubation temperature in Forster’s terns in relation to mercury contamination

    Science.gov (United States)

    Taylor, Gregory T.; Ackerman, Joshua T.; Shaffer, Scott A.

    2018-01-01

    Egg turning behavior is an important determinant of egg hatchability, but it remains relatively understudied. Here, we examined egg turning rates and egg temperatures in Forster’s terns (Sterna forsteri). We used artificial eggs containing a data logger with a 3-D accelerometer, a magnetometer, and a temperature thermistor to monitor parental incubation behavior of 131 tern nests. Overall, adults turned their eggs an average (±SD) of 3.8 ± 0.8 turns h-1, which is nearly two times higher than that of other seabirds. Egg turning rates increased with nest initiation date. We also examined egg turning rates and egg temperatures in relation to egg mercury contamination. Mercury contamination has been shown to be associated with reduced egg hatchability, and we hypothesized that mercury may decrease egg hatchability via altered egg turning behavior by parents. Despite the high variability in egg turning rates among individuals, the rate of egg turning was not related to mercury concentrations in sibling eggs. These findings highlight the need for further study concerning the potential determinants of egg turning behavior.

  19. Kinetic analysis of ski turns based on measured ground reaction forces.

    Science.gov (United States)

    Vaverka, Frantisek; Vodickova, Sona; Elfmark, Milan

    2012-02-01

    The objective of this study was to devise a method of kinetic analysis of the ground reaction force that enables the durations and magnitudes of forces acting during the individual phases of ski turns to be described exactly. The method is based on a theoretical analysis of physical forces acting during the ski turn. Two elementary phases were defined: (1) preparing to turn (initiation) and (2) actual turning, during which the center of gravity of the skier-ski system moves along a curvilinear trajectory (steering). The starting point of the turn analysis is a dynamometric record of the resultant acting ground reaction force applied perpendicularly on the ski surface. The method was applied to six expert skiers. They completed a slalom course comprising five gates arranged on the fall line of a 26° slope at a competition speed using symmetrical carving turns (30 evaluated turns). A dynamometric measurement system was placed on the carving skis (168 cm long, radius 16 m, data were recorded at 100 Hz). MATLAB procedures were used to evaluate eight variables during each turn: five time variables and three force variables. Comparison of the turn analysis results between individuals showed that the method is useful for answering various research questions associated with ski turns.

  20. The "symmetrical turn" in the study of colective action

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    Israel Rodríguez Giralt

    2008-11-01

    Full Text Available Conceptualising and understanding forms of collective action is one of the historic preoccupations of social thought. Good evidence of this can be found in the long line of disputes and polemics that runs through the history of thought about these social phenomena. It shows the difficulty social sciences have faced, and continue to face, when it comes to defining, explaining and delineating a phenomena as ephemeral and liminal as this one.In this context, I propose that a discussion of the implications an STS focus could have for the analysis of contemporary collective action. The main hypothesis I develop states that the conceptual and methodological baggage that goes with the Actor-Network theory (ANT, and its shaping into what has been called the 'symmetrical turn' in the social sciences, become a fundamental resource for renewing and enriching the analysis of collective action. For this, I will bring together two main contributions: its alternative understanding of social action (to explain the social it is necessary to  leave the exclusive concern with social relations aside and take into account the non-human actors, such as the technical procedures in which they are involved; and its original definition of the “collective” (the collective is basically an aggregate of humans and non-humans, without predefined borders, it is just the relational product created by the constant and precarious commitment between heterogeneous elements. Both contributions, I affirm, allow the opening of an interesting discussion about agency and the possibility of articulating a new theory of collective action that differs from the dominant traditions in that it considers and assumes the heterogeneous and relational character of all social actors, and, as such, it also assumes that all social action is the emergent effect, the interactive product of those hybrid collectives in action. To give an example of the fertility of this approach, I focus on an

  1. Investigation on quench initiation and propagation characteristics of GdBCO coil co-wound with a stainless steel tape as turn-to-turn metallic insulation.

    Science.gov (United States)

    Kim, Y G; Song, J B; Choi, Y H; Yang, D G; Kim, S G; Lee, H G

    2016-11-01

    This paper investigates the quench initiation and propagation characteristics of a metallic insulation (MI) coil by conducting thermal quench tests for a GdBCO single-pancake coil co-wound with a stainless steel tape as the turn-to-turn MI. The test results confirmed that the MI coil exhibited superior thermal and electrical stabilities compared to the conventional coils co-wound with organic insulation material because the operating current could flow along the radial direction due to the existence of a turn-to-turn contact when a local hot spot was generated. The results of the quench test at a heater current (Ih) of 12, 13, and 14 A indicate that the MI coil possesses a self-protecting characteristic resulting from the "current bypass" through the turn-to-turn contact. However, the test coil was not self-protecting at Ih = 15 A because the Joule heat energy generated by the radial current flow was not completely dissipated due to the characteristic resistance of the metallic insulation tape and the non-superconducting materials, including the substrate, stabilizer, and buffer layers within the high-temperature superconductor (HTS) tape. Even though the MI coil possesses superior thermal and electrical stability relative to those of conventional HTS coils co-wound with an organic material as turn-to-turn insulation, it is essential to consider the critical role of the Joule heat energy resulting from the operating current and stored magnetic energy as well as the characteristic resistances in order to further develop self-protective 2G HTS magnets.

  2. Thermal effects and dynamical hysteresis in the turn-on and turn-off of vertical-cavity surface-emitting lasers.

    Science.gov (United States)

    Hong, Yanhua; Masoller, Cristina; Torre, Maria S; Priyadarshi, Sanjay; Qader, Abdulqader A; Spencer, Paul S; Shore, K Alan

    2010-11-01

    Thermal effects and dynamical hysteresis in VCSELs under dc modulation have been experimentally studied. The results show that the VCSEL turn-on and turn-off currents can display both positive hysteresis and negative hysteresis, depending on the current modulation frequency and on the substrate temperature. Numerical simulations of semiconductor laser rate equations, extended to take into account thermal effects, show a good agreement with the observations.

  3. Correcting false positive medium-chain acyl-CoA dehydrogenase deficiency results from newborn screening; synthesis, purification, and standardization of branched-chain C8 acylcarnitines for use in their selective and accurate absolute quantitation by UHPLC-MS/MS.

    Science.gov (United States)

    Minkler, Paul E; Stoll, Maria S K; Ingalls, Stephen T; Hoppel, Charles L

    2017-04-01

    While selectively quantifying acylcarnitines in thousands of patient samples using UHPLC-MS/MS, we have occasionally observed unidentified branched-chain C8 acylcarnitines. Such observations are not possible using tandem MS methods, which generate pseudo-quantitative acylcarnitine "profiles". Since these "profiles" select for mass alone, they cannot distinguish authentic signal from isobaric and isomeric interferences. For example, some of the samples containing branched-chain C8 acylcarnitines were, in fact, expanded newborn screening false positive "profiles" for medium-chain acyl-CoA dehydrogenase deficiency (MCADD). Using our fast, highly selective, and quantitatively accurate UHPLC-MS/MS acylcarnitine determination method, we corrected the false positive tandem MS results and reported the sample results as normal for octanoylcarnitine (the marker for MCADD). From instances such as these, we decided to further investigate the presence of branched-chain C8 acylcarnitines in patient samples. To accomplish this, we synthesized and chromatographically characterized several branched-chain C8 acylcarnitines (in addition to valproylcarnitine): 2-methylheptanoylcarnitine, 6-methylheptanoylcarnitine, 2,2-dimethylhexanoylcarnitine, 3,3-dimethylhexanoylcarnitine, 3,5-dimethylhexanoylcarnitine, 2-ethylhexanoylcarnitine, and 2,4,4-trimethylpentanoylcarnitine. We then compared their behavior with branched-chain C8 acylcarnitines observed in patient samples and demonstrated our ability to chromographically resolve, and thus distinguish, octanoylcarnitine from branched-chain C8 acylcarnitines, correcting false positive MCADD results from expanded newborn screening. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Stepping in Place While Voluntarily Turning Around Produces a Long-Lasting Posteffect Consisting in Inadvertent Turning While Stepping Eyes Closed

    Directory of Open Access Journals (Sweden)

    Stefania Sozzi

    2016-01-01

    Full Text Available Training subjects to step in place on a rotating platform while maintaining a fixed body orientation in space produces a posteffect consisting in inadvertent turning around while stepping in place eyes closed (podokinetic after-rotation, PKAR. We tested the hypothesis that voluntary turning around while stepping in place also produces a posteffect similar to PKAR. Sixteen subjects performed 12 min of voluntary turning while stepping around their vertical axis eyes closed and 12 min of stepping in place eyes open on the center of a platform rotating at 60°/s (pretests. Then, subjects continued stepping in place eyes closed for at least 10 min (posteffect. We recorded the positions of markers fixed to head, shoulder, and feet. The posteffect of voluntary turning shared all features of PKAR. Time decay of angular velocity, stepping cadence, head acceleration, and ratio of angular velocity after to angular velocity before were similar between both protocols. Both postrotations took place inadvertently. The posteffects are possibly dependent on the repeated voluntary contraction of leg and foot intrarotating pelvic muscles that rotate the trunk over the stance foot, a synergy common to both protocols. We propose that stepping in place and voluntary turning can be a scheme ancillary to the rotating platform for training body segment coordination in patients with impairment of turning synergies of various origin.

  5. Plant breeding in the turn of the millennium

    Directory of Open Access Journals (Sweden)

    Aluízio Borém

    1998-01-01

    Full Text Available The transition from hunting and gathering to farming happened about 10,000 years ago, independently and diffusely in several places in the world. Plant breeders were responsible for genetic progress in a number of crop species. It included hybrids, the introgression of wild species genes and also the Green Revolution, which started in the 1960's with the cereals. The varieties developed by breeding, along with the use of new crop technology (fertilization, soil tillage, etc. changed the status of some countries from importers to exporters of food. In the turn of the millennium,, plant breeding, faces new challenges in a globalized world, but it has new tools to deal with them. Notwithstanding the present contributions of plant breeding and crop management, its future contributions may be even greater. The partnership being developed between plant breeding and biotechnology will assure a more consistent and predictable genetic progress. Current contributions of biotechnology have arrived for many crops in different places of the world. Varieties developed by transformation are grown in large acreage in some countries. Some concerns have also arisen from the use of GMOs. For example, the introgression of a gene for insect resistance 4 into many different species could result in an undesirable endemic risk, here called interespecific biotechnological vulnerability. Another concern is that biotechnology race may create yield plateaus in programs using genes pyramiding for all new traits made available by biotechnology, resulting in what is called genetic gridlock. Nevertheless, the benefits of using biotechnology will substantially enhance the contributions of plant breeding to human lifeA transição da fase de coleta e caça para a agricultura ocorreu há cerca de dez mil anos independentemente e em vários locais no mundo. Naquela época iniciou-se a domesticação da maioria das espécies cultivadas, dando início às atividades agrícolas. Os

  6. The additive effect of turn-taking cues in human and synthetic voice

    OpenAIRE

    2010-01-01

    Abstract A previous line of research suggests that interlocutors identify appropriate places to speak by cues in the behaviour of the preceding speaker. If used in combination, these cues have an additive effect on listeners? turn-taking attempts. The present study further explores these findings by examining the effect of such turn-taking cues experimentally. The objective is to investigate the possibilities of generating turn-taking cues with a synthetic voice. Thus, in addition ...

  7. Decision-Making and Turn Alternation in Pill Bugs (Armadillidium Vulgare)

    OpenAIRE

    Moriyama, Tohru

    1999-01-01

    Twelve pill bugs (Armadillidium vulgare, Isopoda, Cmstacean) were examined in 200 successive T-mazes. When obstacles are present, A. vulgare tend to move by means of turn alternation, which is generally considered an innate adaptive behavior. With a decrease in air moisture, the bugs have a tendency to increase their turn alternation rate. However, in such long successive T-mazes as in this study, continued turn alternation should actually accelerate the bugs' desiccation. This fact implies t...

  8. Turning Vanes in Exhaust Duct Flow: Study for Energy Efficiency, Optimization and Pressure Drop Mitigation

    Science.gov (United States)

    2014-09-01

    gas-turbine engine design, and while they are called guide vanes they serve a similar purpose to those turning vanes used by the heating, venting...effect of the application of a turning vane placed in the 90o bend for the same inlet and outlet boundary conditions that were applied to give the...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited TURNING VANES IN

  9. Head-turning asymmetry: A novel lateralization in rats predicts susceptibility to behavioral despair.

    Science.gov (United States)

    Soyman, Efe; Yilmaz, Guzin Duygu; Canbeyli, Resit

    2017-10-16

    Behavioral markers of laterality reflecting underlying neurobiological asymmetries between the cerebral hemispheres are related to differential susceptibility to mood disorders. In the present study, we investigated the strength and consistency of a novel behavioral lateralization, head-turning asymmetry, and its relation to behavioral despair in adult female Wistar rats. Head-turning biases were determined in a test where water-deprived rats had to turn their head to right or left to gain access to a water dispenser. This procedure was administered 4 times over 8days. Four days after the head-turning test, rats were subjected to two forced swim tests separated by 24h to examine the relationship between head-turning asymmetry and behavioral despair. Rats were administered one more head-turning test session after the second swim test to determine whether behavioral despair induction altered head-turning direction preferences. Results revealed significant correlations among head-turning test sessions indicating head-turning direction preference as measured with our method is a consistent behavioral lateralization. Although most rats were strongly lateralized, there was no bias in either direction at the population level. Importantly, we found that while rats with a left head-turning bias showed a significant increase in the duration of immobility from the first to the second swim test, right-biased rats performed similarly in the two swim tests. Behavioral despair induction did not change head-turning direction preferences. The present findings show that head-turning asymmetries are predictive of mood disorders in rats and may serve as the basis to elucidate the mechanisms relating hemispheric asymmetries to depression in humans. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Perfluoroalkyl Substances, Sex Hormones, and Insulin-like Growth Factor-1 at 6–9 Years of Age: A Cross-Sectional Analysis within the C8 Health Project

    Science.gov (United States)

    Lopez-Espinosa, Maria-Jose; Mondal, Debapriya; Armstrong, Ben G.; Eskenazi, Brenda; Fletcher, Tony

    2016-01-01

    Background: Exposure to some perfluoroalkyl substances (PFAS), such as perfluorohexane sulfonate (PFHxS), perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), and perfluorononanoic acid (PFNA), may alter levels of sex hormones and insulin-like growth factor-1 (IGF-1) in animals. Human studies on this topic are scarce, and none have been conducted in young children. Objectives: We investigated the relationship between levels of PFAS and estradiol, total testosterone, and IGF-1 in 2,292 children (6–9 years of age) from the C8 Health Project who lived near a chemical plant in the Mid-Ohio Valley (USA) with local contamination from PFOA. Methods: Serum samples were collected in 2005–2006 and analyzed for PFAS, sex hormones, and IGF-1. Results from regression models were expressed as the adjusted percentage difference (95% CI) per sex-specific interquartile range (IQR) increment of each PFAS serum concentration. Analyses by PFAS quartiles were also conducted. Results: Median concentrations of PFHxS, PFOA, PFOS, and PFNA were 8, 35, 22, and 1.7 ng/mL in boys and 7, 30, 21, and 1.7 ng/mL in girls. In boys, PFOA concentrations were significantly associated with testosterone levels (–4.9%; 95% CI: –8.7, –0.8%); PFOS with estradiol (–4.0%; 95% CI: –7.7, –0.1%), testosterone (–5.8%; 95% CI: –9.4, –2.0%), and IGF-1 (–5.9%; 95% CI: –8.3, –3.3%); and PFNA with IGF-1 (–3.5%; 95% CI: –6.0, –1.0%). In girls, significant associations were found between PFOS and testosterone (–6.6%; 95% CI: –10.1, –2.8%) and IGF-1 (–5.6%; –8.2, –2.9%); and PFNA and IGF-1 (–3.8%; 95% CI: –6.4, –1.2%). In both sexes, the magnitudes of the associations decreased monotonically across quartiles for both testosterone and IGF-1 in relation to PFOS, and for IGF-1 and PFNA in girls. Conclusions: To our knowledge, this is the first study suggesting that PFAS are associated with lower levels of IGF-1 and sex hormones in young children. Citation: Lopez

  11. A Hirshfeld surface analysis, crystal structure and infrared characterization of a new organic cyclohexaphosphate, (C8H12N)4(Li)2(P6O18)(H2O)6

    Science.gov (United States)

    Khedhiri, L.; Ferretti, V.; Jelsch, C.; Rzaigui, M.; Ben Nasr, C.

    2017-04-01

    Single crystals of a new organic cyclohexaphosphate (C8H12N)4(Li)2(P6O18)(H2O)6 prepared by an acid/base reaction between cyclohexaphosphoric acid H6P6O18 and 2,6-dimethylaniline, have been successfully grown by slow evaporation technique at room temperature. This compound was characterized using X-ray diffraction (XRD) and FT-IR spectroscopy. The results show that the title compound was phased with a triclinic structure and P-1 space group. The crystal structure was solved by using 5203 independent reflections with a final R value of 0.031. The P6O18 ring is centrosymmetrical. Its main geometrical features are those commonly observed in others cyclohexaphosphates. The atomic arrangement of this compound can be described by an organization in a three-dimensional framework, built up from alternated organic and inorganic species. Adjacent P6O18 rings are linked via corner-sharing by LiO4 tetrahedra, generating anionic [Li2(P6O18)(H2O)]4- layers parallel to (110). Charge balance is achieved by the protonated amine which is trapped in the interlayer space and interacts with the organic framework through strong and medium hydrogen bonding. An extensive network of Nsbnd H⋯O and Osbnd H⋯O hydrogen-bonding interactions link the components into a three-dimensional network and additional stabilization is provided by weak Csbnd H⋯O hydrogen bonds. Intermolecular interactions were investigated by Hirshfeld surfaces. The vibrational absorption bands were identified by infrared spectroscopy. The stretching modes of P6O18 ring and band assignments are described.

  12. Characterization of the antifungal activity of Lactobacillus harbinensis K.V9.3.1Np and Lactobacillus rhamnosus K.C8.3.1I in yogurt.

    Science.gov (United States)

    Delavenne, Emilie; Cliquet, Sophie; Trunet, Clément; Barbier, Georges; Mounier, Jérôme; Le Blay, Gwenaëlle

    2015-02-01

    Few antifungal protective cultures adapted to fermented dairy products are commercially available because of the numerous constraints linked to their market implementation. Consumer's demand for naturally preserved food products is growing and the utilization of lactic acid bacteria is a promising way to achieve this goal. In this study, using a 2(5-1) factorial fractional design, we first evaluated the effects of fermentation time, of initial sucrose concentration and of the initial contamination amount of a spoilage yeast, on antifungal activities of single and mixed cultures of Lactobacillus rhamnosus K.C8.3.1I and Lactobacillus harbinensis K.V9.3.1Np in yogurt. L. harbinensis K.V9.3.1Np, the most relevant strain with regard to antifungal activity was then studied to determine its minimal inhibitory inoculation rate, its antifungal stability during storage and its impact on yogurt organoleptic properties. We showed that L. harbinensis K.V9.3.1Np maintained a stable antifungal activity over time, which was not affected by initial sucrose, nor by a reduction of the fermentation time. This inhibitory activity was an all-or-nothing phenomenon. Once L. harbinensis K.V9.3.1Np reached a population of ∼ 2.5 × 10(6) cfu/g of yogurt at the time of contamination, total inhibition of the yeast was achieved. We also showed that an inoculation rate of 5 × 10(6) cfu/ml in milk had no detrimental effect on yogurt organoleptic properties. In conclusion, L. harbinensis K.V9.3.1Np is a promising antifungal bioprotective strain for yogurt preservation. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. Efficiency of static core turn-off in a system-on-a-chip with variation

    Energy Technology Data Exchange (ETDEWEB)

    Cher, Chen-Yong; Coteus, Paul W; Gara, Alan; Kursun, Eren; Paulsen, David P; Schuelke, Brian A; Sheets, II, John E; Tian, Shurong

    2013-10-29

    A processor-implemented method for improving efficiency of a static core turn-off in a multi-core processor with variation, the method comprising: conducting via a simulation a turn-off analysis of the multi-core processor at the multi-core processor's design stage, wherein the turn-off analysis of the multi-core processor at the multi-core processor's design stage includes a first output corresponding to a first multi-core processor core to turn off; conducting a turn-off analysis of the multi-core processor at the multi-core processor's testing stage, wherein the turn-off analysis of the multi-core processor at the multi-core processor's testing stage includes a second output corresponding to a second multi-core processor core to turn off; comparing the first output and the second output to determine if the first output is referring to the same core to turn off as the second output; outputting a third output corresponding to the first multi-core processor core if the first output and the second output are both referring to the same core to turn off.

  14. Classifying Step and Spin Turns Using Wireless Gyroscopes and Implications for Fall Risk Assessments

    Directory of Open Access Journals (Sweden)

    Peter C. Fino

    2015-05-01

    Full Text Available Recent studies have reported a greater prevalence of spin turns, which are more unstable than step turns, in older adults compared to young adults in laboratory settings. Currently, turning strategies can only be identified through visual observation, either in-person or through video. This paper presents two unique methods and their combination to remotely monitor turning behavior using three uniaxial gyroscopes. Five young adults performed 90° turns at slow, normal, and fast walking speeds around a variety of obstacles while instrumented with three IMUs (attached on the trunk, left and right shank. Raw data from 360 trials were analyzed. Compared to visual classification, the two IMU methods’ sensitivity/specificity to detecting spin turns were 76.1%/76.7% and 76.1%/84.4%, respectively. When the two methods were combined, the IMU had an overall 86.8% sensitivity and 92.2% specificity, with 89.4%/100% sensitivity/specificity at slow speeds. This combined method can be implemented into wireless fall prevention systems and used to identify increased use of spin turns. This method allows for longitudinal monitoring of turning strategies and allows researchers to test for potential associations between the frequency of spin turns and clinically relevant outcomes (e.g., falls in non-laboratory settings.

  15. Turn-taking in Human Communication--Origins and Implications for Language Processing.

    Science.gov (United States)

    Levinson, Stephen C

    2016-01-01

    Most language usage is interactive, involving rapid turn-taking. The turn-taking system has a number of striking properties: turns are short and responses are remarkably rapid, but turns are of varying length and often of very complex construction such that the underlying cognitive processing is highly compressed. Although neglected in cognitive science, the system has deep implications for language processing and acquisition that are only now becoming clear. Appearing earlier in ontogeny than linguistic competence, it is also found across all the major primate clades. This suggests a possible phylogenetic continuity, which may provide key insights into language evolution. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Experimental investigation of the ultra-precision turning capability of PVD ZnSe

    Science.gov (United States)

    Li, Wei-hao; Yang, Kun; Wang, Peng; Zhang, Gao-feng; Liu, Dan-dan

    2016-10-01

    ZnSe is widely used in infrared optical systems because of the good optical characteristics in 0.5 22μm and the good processability. Physical Vapor Deposition(PVD) of ZnSe is good at no pollution in production process, lower price, etc. Infrared optical parts should be made by single point diamond turning or single point diamond fly-cutting after the experimental investigation of the ultra-precision turning capability of PVD ZnSe. The orthogonal experiment of ultra-precision turning PVD ZnSe was done at first, then the smooth turning surface and the rough turning surface were observed by metallographic microscope and 3D profilometer, and the mechanism of the defects on the turning surface was discussed. The result shows: the quality of ultra-precision turning surface of PVD ZnSe was restricted by the grain size and the distribution of the grain which could easily cause the variegated macula at the grain size, rising the spindle speed, reducing the feed rate and reducing the cut depth could make the quality of ultra-precision turning surface better and reduce the roughness Ra value lower, the roughness Ra value of the smooth turning surface was reached 3 4nm which is enough to the infrared optical image systems currently by using the optimization of parameters.

  17. Effect of turning parameters on metal removal and tool wear rates of ...

    African Journals Online (AJOL)

    Therefore, optimum machining parameters suitable for turning operations must be selected in other to obtain the desired quality of the finished product at reduced machining time and cost. The present study was carried out on AISI 1018 low carbon steel during turning operation to reduce tooling costs as a result of tool wear ...

  18. Differences of Ballet Turns ("Pirouette") Performance between Experienced and Novice Ballet Dancers

    Science.gov (United States)

    Lin, Chia-Wei; Chen, Shing-Jye; Su, Fong-Chin; Wu, Hong-Wen; Lin, Cheng-Feng

    2014-01-01

    Purpose: This study investigated the different postural control strategies exhibited by experienced and novice dancers in ballet turns ("pirouettes"). Method: Thirteen novice and 13 experienced dancers performed ballet turns with dominant-leg support. The peak push force was measured in the double-leg support phase. The inclination…

  19. Possibilities in the Boy Turn? Comparative Lessons from Australia and Iceland

    Science.gov (United States)

    Johannesson, Ingolfur Asgeir; Lingard, Bob; Mills, Martin

    2009-01-01

    Recognising that there is now a globalised educational discourse about "failing boys" circulating in the privileged nations of the global north, this article provides a comparative perspective on educational policy responses to the "boy turn" in Australia and Iceland. Specificities of the responses to the boy turn in the two…

  20. effect of turning parameters on metal removal and tool wear rates

    African Journals Online (AJOL)

    user

    The quality of machined parts and tooling costs are major challenges encountered during the turning process. Therefore, optimum machining parameters suitable for turning operations must be selected in other to obtain the desired quality of the finished product at reduced machining time and cost. The present study was ...

  1. How turn-taking strategies influence users’ impressions of an agent

    NARCIS (Netherlands)

    ter Maat, Mark; Truong, Khiet Phuong; Heylen, Dirk K.J.; Allbeck, Jan; Badler, Norman; Bickmore, Timothy; Pelachaud, Catherine; Safonova, Alla

    Different turn-taking strategies of an agent influence the impression that people have of it. We recorded conversations of a human with an interviewing agent, controlled by a wizard and using a particular turn-taking strategy. A questionnaire with 27 semantic differential scales concerning

  2. Gramicidin S derivatives containing cis- and trans-morpholine amino acids (MAAS) as turn mimetics

    NARCIS (Netherlands)

    Kapoerchan, V.V.; Spalburg, E.; Neeling, A.J. de; Mars-Groenendijk, R.H.; Noort, D.; Otero, J.M. de; Ferraces-Casais, P.; Llamas-Saiz, A.L.; Raaij, M.J. van; Doorn, J. van; Marel, G.A. van der; Overkleeft, H.S.; Overhand, M.

    2010-01-01

    The cyclic decapeptide gramicidin S (GS) was used as a model for the evaluation of four turn mimetics. For this purpose, one of the D-Phe-Pro two-residue turn motifs in the rigid cyclic β-hairp0in structure of GS was replaced with morpholine amino acids (MAA 2-5), differing in stereochemistry and

  3. Gramicidin S derivatives containing cis- and trans-morpholine amino acids (MAAs) as turn mimetics

    NARCIS (Netherlands)

    Kapoerchan, V.V.; Spalburg, E.; Neeling, de A.J.; Mars-Groenendijk, R.H.; Noort, D.; Otero, J.M.; Ferraces-Casais, P.; Llamas-Saiz, A.L.; Raaij, van M.J.; Doorn, van J.; Marel, van der G.A.; Overkleeft, H.S.; Overhand, M.

    2010-01-01

    The cyclic decapeptide gramicidin S (GS) was used as a model for the evaluation of four turn mimetics. For this purpose, one of the D-Phe-Pro two-residue turn motifs in the rigid cyclic -hairpin structure of GS was replaced with morpholine amino acids (MAA 2-5), differing in stereochemistry and

  4. Estimation Method for Turn-off Collector Voltage of IGBTs Using Emitter-auxiliary Inductor

    DEFF Research Database (Denmark)

    Luo, Haoze; Iannuzzo, Francesco; Blaabjerg, Frede

    2016-01-01

    of high-voltage and high-power IGBT module, there exists an emitter-auxiliary inductor between the power emitter and Kelvin emitter. The same variable dic/dt during turn-off transition will also induce a measurable voltage veE across the emitter-auxiliary inductor LeE. As a result, the hazardous turn...

  5. Computational models of social and emotional turn-taking for embodied conversational agents: a review

    NARCIS (Netherlands)

    op den Akker, Hendrikus J.A.; Bruijnes, Merijn

    2012-01-01

    The emotional involvement of participants in a conversation not only shows in the words they speak and in the way they speak and gesture but also in their turn-taking behavior. This paper reviews research into computational models of embodied conversational agents. We focus on models for turn-taking

  6. Turning Points during the Life of Student Project Teams: A Qualitative Study

    Science.gov (United States)

    Raes, Elisabeth; Kyndt, Eva; Dochy, Filip

    2015-01-01

    In this qualitative study a more flexible alternative of conceptualising changes over time in teams is tested within student project teams. The conceptualisation uses turning points during the lifespan of a team to outline team development, based on work by Erbert, Mearns, & Dena (2005). Turning points are moments that made a significant…

  7. You cannot speak and listen at the same time: a probabilistic model of turn-taking.

    Science.gov (United States)

    Donnarumma, Francesco; Dindo, Haris; Iodice, Pierpaolo; Pezzulo, Giovanni

    2017-04-01

    Turn-taking is a preverbal skill whose mastering constitutes an important precondition for many social interactions and joint actions. However, the cognitive mechanisms supporting turn-taking abilities are still poorly understood. Here, we propose a computational analysis of turn-taking in terms of two general mechanisms supporting joint actions: action prediction (e.g., recognizing the interlocutor's message and predicting the end of turn) and signaling (e.g., modifying one's own speech to make it more predictable and discriminable). We test the hypothesis that in a simulated conversational scenario dyads using these two mechanisms can recognize the utterances of their co-actors faster, which in turn permits them to give and take turns more efficiently. Furthermore, we discuss how turn-taking dynamics depend on the fact that agents cannot simultaneously use their internal models for both action (or messages) prediction and production, as these have different requirements-or, in other words, they cannot speak and listen at the same time with the same level of accuracy. Our results provide a computational-level characterization of turn-taking in terms of cognitive mechanisms of action prediction and signaling that are shared across various interaction and joint action domains.

  8. Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation

    DEFF Research Database (Denmark)

    Hauge, Camilla; Antal, Torben L; Hirschberg, Daniel

    2007-01-01

    investigated the role of the third, so-called turn motif phosphate, also located in the tail, in the AGC kinases PKB, S6K, RSK, MSK, PRK and PKC. We report cooperative action of the HM phosphate and the turn motif phosphate, because it binds a phosphoSer/Thr-binding site above the glycine-rich loop within...

  9. Toward Real-Time Automated Detection of Turns during Gait Using Wearable Inertial Measurement Units

    Directory of Open Access Journals (Sweden)

    Domen Novak

    2014-10-01

    Full Text Available Previous studies have presented algorithms for detection of turns during gait using wearable sensors, but those algorithms were not built for real-time use. This paper therefore investigates the optimal approach for real-time detection of planned turns during gait using wearable inertial measurement units. Several different sensor positions (head, back and legs and three different detection criteria (orientation, angular velocity and both are compared with regard to their ability to correctly detect turn onset. Furthermore, the different sensor positions are compared with regard to their ability to predict the turn direction and amplitude. The evaluation was performed on ten healthy subjects who performed left/right turns at three amplitudes (22, 45 and 90 degrees. Results showed that turn onset can be most accurately detected with sensors on the back and using a combination of orientation and angular velocity. The same setup also gives the best prediction of turn direction and amplitude. Preliminary measurements with a single amputee were also performed and highlighted important differences such as slower turning that need to be taken into account.

  10. The effects of processing and sequence organization on the timing of turn taking: a corpus study

    Science.gov (United States)

    Roberts, Seán G.; Torreira, Francisco; Levinson, Stephen C.

    2015-01-01

    The timing of turn taking in conversation is extremely rapid given the cognitive demands on speakers to comprehend, plan and execute turns in real time. Findings from psycholinguistics predict that the timing of turn taking is influenced by demands on processing, such as word frequency or syntactic complexity. An alternative view comes from the field of conversation analysis, which predicts that the rules of turn-taking and sequence organization may dictate the variation in gap durations (e.g., the functional role of each turn in communication). In this paper, we estimate the role of these two different kinds of factors in determining the speed of turn-taking in conversation. We use the Switchboard corpus of English telephone conversation, already richly annotated for syntactic structure speech act sequences, and segmental alignment. To this we add further information including Floor Transfer Offset (the amount of time between the end of one turn and the beginning of the next), word frequency, concreteness, and surprisal values. We then apply a novel statistical framework (“random forests”) to show that these two dimensions are interwoven together with indexical properties of the speakers as explanatory factors determining the speed of response. We conclude that an explanation of the of the timing of turn taking will require insights from both processing and sequence organization. PMID:26029125

  11. CNC Turning Center Advanced Operations. Computer Numerical Control Operator/Programmer. 444-332.

    Science.gov (United States)

    Skowronski, Steven D.; Tatum, Kenneth

    This student guide provides materials for a course designed to introduce the student to the operations and functions of a two-axis computer numerical control (CNC) turning center. The course consists of seven units. Unit 1 presents course expectations and syllabus, covers safety precautions, and describes the CNC turning center components, CNC…

  12. The role of the clause for turn-taking in Dutch conversations

    NARCIS (Netherlands)

    Huiskes, M.

    2010-01-01

    In spontaneous conversations, interactants are able to place new turns at the boundary of a foregoing turn without any noticeable gap or overlap. This suggests that interactions are made up of clearly identifiable units that are oriented to by the participants. It also shows that these interactional

  13. A new method of on-line turned surface monitoring by digital image processing

    Directory of Open Access Journals (Sweden)

    Mai Qingqun

    2016-01-01

    Full Text Available A machined surface can be seen as a replica of the geometric outline of the cutting tool nose during the process of cylindrical turning, and the texture of the machined surface varies along with the tool wear. A new method of on-line turned surface monitoring is proposed in this paper by studying the grey value characteristics of the turned surface digital image. The regularity of the surface image is judged and analysed by using wavelet transform, fractal analysis, and discreteness analysis of the wavelength of the texture contour. The average wave contour, which can reflect processing state and the condition of the turned surface, is extracted from the regular texture image. Experimental results show that the turned surface condition can be monitored on-line effectively with the presented method.

  14. Stochastic User Equilibrium Traffic Assignment with Turn-delays in Intersections

    DEFF Research Database (Denmark)

    Nielsen, Otto Anker; Simonsen, Nikolaj; Frederiksen, Rasmus Dyhr

    1997-01-01

    Turn-delays in intersections contribute significant to travel times and thus route choices in urban networks. However, turns are difficult to handle in traffic assignment models due to the asymmetric Jacobian in the cost functions. The paper describes a model where turn delays have been included...... in the solution algorithm of Sto-chastic User Equilibrium traffic assignment (SUE). When the Jacobian is symme-tric, SUE minimises the road users' 'perceived travel resistance’s'. This equals a probit-model where the links cost-functions are traffic dependent. Hereby, overlap-ping routes are handled...... on a full-scale network. Therefore, an essential part of the paper presents practical tests of convergence. Both geometric delays and delays caused by other turns are considered for each turn. Signalised and non-signalised intersec-tions are handled in different ways, as are roundabouts. In signalised...

  15. The use of turning tasks in clinical gait analysis for children with cerebral palsy.

    Science.gov (United States)

    Dixon, Philippe C; Stebbins, Julie; Theologis, Tim; Zavatsky, Amy B

    2016-02-01

    Turning while walking is a crucial component of locomotion that is performed using an outside (step) or inside (spin) limb strategy. The aims of this paper were to determine how children with cerebral palsy perform turning maneuvers and if specific kinematic and kinetic adaptations occur compared to their typically developing peers. Motion capture data from twenty-two children with cerebral palsy and fifty-four typically developing children were collected during straight and 90° turning gait trials. Experimental data were used to compute spatio-temporal parameters, margin of stability, ground reaction force impulse, as well as joint kinematics and kinetics. Both child groups preferred turning using the spin strategy. The group of children with cerebral palsy exhibited the following adaptations during turning gait compared to the typically developing group: stride length was decreased across all phases of the turn with largest effect size for the depart phase (2.02), stride width was reduced during the turn phase, but with a smaller effect size (0.71), and the average margin of stability during the approach phase of turning was reduced (effect size of 0.98). Few overall group differences were found for joint kinematic and kinetic measures; however, in many cases, the intra-subject differences between straight walking and turning gait were larger for the majority of children with cerebral palsy than for the typically developing children. In children with cerebral palsy, turning gait may be a better discriminant of pathology than straight walking and could be used to improve the management of gait abnormalities. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. The management of turn transition in signed interaction through the lens of overlaps

    Directory of Open Access Journals (Sweden)

    Simone eGirard-Groeber

    2015-06-01

    Full Text Available There have been relatively few studies on sign language interaction carried out within the framework of conversation analysis (CA. Therefore, questions remain open about how the basic building blocks of social interaction such as turn, turn construction unit (TCU and turn transition relevance place (TRP can be understood and analysed in sign language interaction. Recent studies have shown that signers regularly fine-tune their turn-beginnings to potential completion points of turns (De Vos, Torreira & Levinson, 2015; Groeber, 2014; Groeber & Pochon-Berger, 2014. Moreover, signers deploy practices for overlap resolution as in spoken interaction (McCleary & Leite, 2013. While these studies have highlighted the signers’ orientation to the ‘one-at-a-time’ principle described by Sacks et al., (1974, the present article adds to this line of research by investigating in more detail those sequential environments where overlaps occur. The contribution provides an overview of different types of overlap with a focus of the overlap’s onset with regard to a current signer’s turn. On the basis of a 33-minute video-recording of a multi-party interaction between 4 female signers in Swiss German Sign Language (DSGS, the paper provides evidence for the orderliness of overlapping signing. Furthermore, the contribution demonstrates how participants collaborate in the situated construction of turns as a dynamic and emergent gestalt and how they interactionally achieve turn transition. Thereby the study adds to recent research in spoken and in signed interaction that proposes to rethink turn boundaries and turn transition as flexible and interactionally achieved.

  17. The management of turn transition in signed interaction through the lens of overlaps.

    Science.gov (United States)

    Girard-Groeber, Simone

    2015-01-01

    There have been relatively few studies on sign language interaction carried out within the framework of conversation analysis (CA). Therefore, questions remain open about how the basic building blocks of social interaction such as turn, turn construction unit (TCU) and turn transition relevance place (TRP) can be understood and analyzed in sign language interaction. Recent studies have shown that signers regularly fine-tune their turn-beginnings to potential completion points of turns (Groeber, 2014; Groeber and Pochon-Berger, 2014; De Vos et al., 2015). Moreover, signers deploy practices for overlap resolution as in spoken interaction (McCleary and Leite, 2013). While these studies have highlighted the signers' orientation to the "one-at-a-time" principle described by Sacks et al. (1974), the present article adds to this line of research by investigating in more detail those sequential environments where overlaps occur. The contribution provides an overview of different types of overlap with a focus of the overlap's onset with regard to a current signer's turn. On the basis of a 33-min video-recording of a multi-party interaction between 4 female signers in Swiss German Sign Language (DSGS), the paper provides evidence for the orderliness of overlapping signing. Furthermore, the contribution demonstrates how participants collaborate in the situated construction of turns as a dynamic and emergent gestalt and how they interactionally achieve turn transition. Thereby the study adds to recent research in spoken and in signed interaction that proposes to rethink turn boundaries and turn transition as flexible and interactionally achieved.

  18. A method for simultaneous linear optics and coupling correction for storage rings with turn-by-turn beam position monitor data

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Xi [Brookhaven National Laboratory, Upton, Long Island, NY 11973 (United States); Huang, Xiaobiao, E-mail: xiahuang@slac.stanford.edu [SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States)

    2016-08-21

    We propose a method to simultaneously correct linear optics errors and linear coupling for storage rings using turn-by-turn (TbT) beam position monitor (BPM) data. The independent component analysis (ICA) method is used to isolate the betatron normal modes from the measured TbT BPM data. The betatron amplitudes and phase advances of the projections of the normal modes on the horizontal and vertical planes are then extracted, which, combined with dispersion measurement, are used to fit the lattice model. The fitting results are used for lattice correction. The method has been successfully demonstrated on the NSLS-II storage ring.

  19. A method for simultaneous linear optics and coupling correction for storage rings with turn-by-turn beam position monitor data

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Xi; Huang, Xiaobiao

    2016-08-01

    We propose a method to simultaneously correct linear optics errors and linear coupling for storage rings using turn-by-turn (TbT) beam position monitor (BPM) data. The independent component analysis (ICA) method is used to isolate the betatron normal modes from the measured TbT BPM data. The betatron amplitudes and phase advances of the projections of the normal modes on the horizontal and vertical planes are then extracted, which, combined with dispersion measurement, are used to fit the lattice model. The fitting results are used for lattice correction. The method has been successfully demonstrated on the NSLS-II storage ring.

  20. A method for simultaneous linear optics and coupling correction for storage rings with turn-by-turn beam position monitor data

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Xi [Brookhaven National Lab. (BNL), Upton, NY (United States); Huang, Xiaobiao [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2016-08-01

    We propose a method to simultaneously correct linear optics errors and linear coupling for storage rings using turn-by-turn (TbT) beam position monitor (BPM) data. The independent component analysis (ICA) method is used to isolate the betatron normal modes from the measured TbT BPM data. The betatron amplitudes and phase advances of the projections of the normal modes on the horizontal and vertical planes are then extracted, which, combined with dispersion measurement, are used to fit the lattice model. Furthermore, the fitting results are used for lattice correction. Our method has been successfully demonstrated on the NSLS-II storage ring.

  1. Computation of the Coupling Resonance Driving term f1001 and the coupling coefficient C from turn-by-turn single-BPM data.

    CERN Document Server

    Franchi, A; Vanbavinkhove, G; CERN. Geneva. BE Department

    2010-01-01

    In this note we show how to compute the Resonance Driving Term (RDT) f1001, the local resonance term chi 1010 and the coupling coefficient C from the spectrum of turn-by-turn single-BPM data. The harmonic analysis of real coordinate x(y) is model independent, conversely to the the analysis of the complex Courant-Snyder coordinate hx,- = x-ipx. From the computation of f1001 along the ring is closely related to the global coupling coefficient C, but it is affected by an intrinsic error, discussed in this note.

  2. Investigation of flame driving and flow turning in axial solid rocket instabilities

    Science.gov (United States)

    Zinn, Ben T.; Daniel, Brady R.; Matta, Lawrence M.

    1993-08-01

    An understanding of the processes responsible for driving and damping acoustic oscillations in solid rocket motors is necessary for developing practical design methods that eliminate or reduce the occurrence combustion instabilities. While state of the art solid rocket stability prediction methods generally account for the flow turning loss, the magnitude and characteristics of this loss have never been fully investigated. Results of an investigation of the role of the flow turning loss in the stability of solid rockets and its dependence upon motor design and operating parameters are described. A one dimensional acoustic stability equation that verifies that the flow turning loss term is appropriately included in the one dimensional stability formulation was derived for a chamber with a constant mean temperature and pressure by an approach independent from that of Culick. This study was extended providing the background and expressions needed to guide an experimental study of the flow turning loss in the presence of mean temperature and density gradients. This allows the study of combustion systems in which mean temperature gradients and heat losses are significant. The relevant conservation equations were solved numerically for the experimental configuration in order to predict the behavior of the flow turning loss and to assist in the analysis of experimental results. Experiments performed, with and without combustion, showed that the flow turning loss strongly depends upon the propellant burning rate and the location of the flow turning region relative to the standing pressure wave.

  3. Prosodic Variation and Segmental Reduction and Their Roles in Cuing Turn Transition in Swedish.

    Science.gov (United States)

    Zellers, Margaret

    2017-09-01

    Prosody has often been identified alongside syntax as a cue to turn hold or turn transition in conversational interaction. However, evidence for which prosodic cues are most relevant, and how strong those cues are, has been somewhat scattered. The current study addresses prosodic cues to turn transition in Swedish. A perception study looking closely at turn changes and holds in cases where the syntax does not lead inevitably to a particular outcome shows that Swedish listeners are sensitive to duration variations, even in the very short space of the final unstressed syllable of a turn, and that they may use pitch cues to a lesser extent. An investigation of production data indicates that duration, and to some extent segmental reduction, demonstrate consistent variation in relation to the types of turn boundaries they accompany, while fundamental frequency and glottalization do not. Taken together, these data suggest that duration may be the primary cue to turn transition in Swedish conversation, rather than fundamental frequency, as some other studies have suggested.

  4. As the egg turns: monitoring egg attendance behavior in wild birds using novel data logging technology.

    Science.gov (United States)

    Shaffer, Scott A; Clatterbuck, Corey A; Kelsey, Emma C; Naiman, Alex D; Young, Lindsay C; VanderWerf, Eric A; Warzybok, Pete; Bradley, Russell; Jahncke, Jaime; Bower, Geoff C

    2014-01-01

    Egg turning is unique to birds and critical for embryonic development in most avian species. Technology that can measure changes in egg orientation and temperature at fine temporal scales (1 Hz) was neither readily available nor small enough to fit into artificial eggs until recently. Here we show the utility of novel miniature data loggers equipped with 3-axis (i.e., triaxial) accelerometers, magnetometers, and a temperature thermistor to study egg turning behavior in free-ranging birds. Artificial eggs containing egg loggers were deployed in the nests of three seabird species for 1-7 days of continuous monitoring. These species (1) turned their eggs more frequently (up to 6.5 turns h(-1)) than previously reported for other species, but angular changes were often small (1-10° most common), (2) displayed similar mean turning rates (ca. 2 turns h(-1)) despite major differences in reproductive ecology, and (3) demonstrated distinct diurnal cycling in egg temperatures that varied between 1.4 and 2.4 °C. These novel egg loggers revealed high-resolution, three-dimensional egg turning behavior heretofore never measured in wild birds. This new form of biotechnology has broad applicability for addressing fundamental questions in avian breeding ecology, life history, and development, and can be used as a tool to monitor birds that are sensitive to disturbance while breeding.

  5. As the egg turns: monitoring egg attendance behavior in wild birds using novel data logging technology.

    Directory of Open Access Journals (Sweden)

    Scott A Shaffer

    Full Text Available Egg turning is unique to birds and critical for embryonic development in most avian species. Technology that can measure changes in egg orientation and temperature at fine temporal scales (1 Hz was neither readily available nor small enough to fit into artificial eggs until recently. Here we show the utility of novel miniature data loggers equipped with 3-axis (i.e., triaxial accelerometers, magnetometers, and a temperature thermistor to study egg turning behavior in free-ranging birds. Artificial eggs containing egg loggers were deployed in the nests of three seabird species for 1-7 days of continuous monitoring. These species (1 turned their eggs more frequently (up to 6.5 turns h(-1 than previously reported for other species, but angular changes were often small (1-10° most common, (2 displayed similar mean turning rates (ca. 2 turns h(-1 despite major differences in reproductive ecology, and (3 demonstrated distinct diurnal cycling in egg temperatures that varied between 1.4 and 2.4 °C. These novel egg loggers revealed high-resolution, three-dimensional egg turning behavior heretofore never measured in wild birds. This new form of biotechnology has broad applicability for addressing fundamental questions in avian breeding ecology, life history, and development, and can be used as a tool to monitor birds that are sensitive to disturbance while breeding.

  6. The turning point in the number of traffic fatalities: two hypotheses about changes in underlying trends.

    Science.gov (United States)

    Brüde, Ulf; Elvik, Rune

    2015-01-01

    The number of traffic fatalities reached a peak in many highly motorised countries around 1970. Some previous studies have suggested that the turning point in the number of traffic fatalities was inevitable and did not reflect a change in the underlying trends influencing the number of traffic fatalities. Other studies suggest that trends in traffic growth and fatality rate changed from before to after the turning point. This paper proposes two hypotheses about the turning point in the number of traffic fatalities. One hypothesis is that the long-term trends in traffic growth and fatality rate were the same before and after the turning point. The other hypothesis is that the long-term trends in traffic growth and fatality rate were different before and after the turning point was reached, in particular that the annual percentage decline in fatality rate became greater after the turning point than before. Such a change would suggest that road safety policy became more effective. Analysis of data for six countries (Denmark, Great Britain, Netherlands, Norway, Sweden, United States) lends stronger support to the latter hypothesis than to the former. The lesson for policy makers, in particular in countries where the number of traffic fatalities is still growing, is that they should not expect a turning point to be reached without policy interventions. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. Band spreading in two-dimensional microchannel turns for electrophoretic or electroosmotic species transport

    Energy Technology Data Exchange (ETDEWEB)

    S. K. Griffiths; R. H. Nilson

    2000-03-01

    Analytical and numerical methods are employed to investigate species transport by electrophoretic or electroosmotic motion in the curved geometry of a two-dimensional turn. Closed-form analytical solutions describing the turn-induced diffusive and dispersive spreading of a species band are presented for both the low and high Peclet number limits. The authors find that the spreading due to dispersion is proportional to the product of the turn included angle and the Peclet number at low Peclet numbers. It is proportional to the square of the included angle and independent of the Peclet number when the Peclet number is large. A composite solution applicable to all Peclet numbers is constructed from these limiting behaviors. Numerical solutions for species transport in a turn are also presented over a wide range of the included angle and the mean turn radius. Based on comparisons between the analytical and numerical results, the authors find that the analytical solutions provide very good estimates of both dispersive and diffusive spreading provided that the mean turn radius exceeds the channel width. These new solutions also agree well with data from a previous study. Optimum conditions minimizing total spreading in a turn are presented and discussed.

  8. Muscle activity in the slalom turn of alpine skiing and in-line skating.

    Science.gov (United States)

    Zeglinksi, C M; Swanson, S C; Self, B P; Greenwald, R M

    1998-10-01

    The electromyographic (EMG) activity of seven muscles of the trunk and lower extremity in five male masters level ski racers during a slalom turn in both alpine skiing and in-line skating was recorded using a telemetry system. Measurements were made on separate testing days using slopes commonly used in each activity (24 slope alpine skiing, 5 in-line skating). Qualitative video recorded at 60 Hz was analyzed to partition the turning cycle in both slalom skiing and in-line skating into initiation and turning phases. The EMG data from each turning cycle were normalized to standard isometric contractions (SIC's) for each muscle in order to quantitatively compare the amplitude characteristics of each phase of the turning cycle in both slalom skiing and in-line skating. The turning phase of in-line skating was found to be significantly longer (55%) than in slalom skiing, most likely due to significantly lower subject velocities recorded during in-line skating (8.5 m/s vs 10.2 m/s). All muscles were active at moderate to high levels (48-172% of SIC) during each phase of the turning cycle in both slalom skiing and in-line skating. The EMG amplitude characteristics were similar for six of the muscles in both slalom skiing and in-line skating for each of the turning phases. Only the erector spinae displayed significantly higher average and peak amplitudes in slalom skiing for both phases. It is concluded that the muscle activity patterns associated with the slalom turn of in-line skating are similar but notably more quasi-static than in slalom skiing.

  9. Latching/Rush-Through as a Turn-Holding Device and Its Functions in Retrospectively Oriented Pre-Emptive Turn Continuation: Findings from Mandarin Conversation

    Science.gov (United States)

    Zhang, Wei

    2012-01-01

    This article offers an interactional account of turn continuations in Chinese conversation, which are characterized as (a) being effected by latching/rush-through, (b) being clauses with predicates, either main or adverbial, and (c) taking a retrospective orientation in the kind of interactional work they do. Close examination reveals that while,…

  10. Application of the H∞ filter in high speed turn maneuvering target tracking algorithm

    Science.gov (United States)

    Lei, Zhenda; Ma, Chuncao; Sun, Hongwei; Han, Yu

    2016-04-01

    High speed, low flying and high Maneuvering, Good methods are needed in high speed Turn maneuvering tracking algorithm. An adaptive version of the H∞ filter which has a practical real-time implementations developed in the paper and it is demonstrated that it has superior worst case performance when compared with the standard Kaman filter to target tracking. when used in turn maneuvering tracking algorithm, the new filter yields improved worst-case performance in the case of model uncertainties. The simulation results indicate that the real-tine maneuvering target turn tracking algorithm can maintain track under severe correlates maneuvers.

  11. An electrochemical cell for the efficient turn around of wafer working electrodes.

    Science.gov (United States)

    Wozniak, Nicholas R; Frey, Alyssa A; Osterbur, Lucas W; Boman, Timothy S; Hampton, Jennifer R

    2010-03-01

    We present a new design for an electrochemical cell for use with wafer working electrodes. The key feature of the design is the use of half turn thumb screws to form a liquid-tight seal between an o-ring and the sample surface. The assembly or disassembly of the cell requires a half turn of each thumb screw, which facilitates the quick turn around of wafer samples. The electrochemical performance of the cell is demonstrated by cyclic voltammetry and double step chronoamperometry measurements of the ferricyanide/ferrocyanide couple.

  12. Investigation of the flow turning loss in unstable solid propellant rocket motors

    Science.gov (United States)

    Matta, Lawrence Mark

    The goal of this study was to improve the understanding of the flow turning loss, which contributes to the damping of axial acoustic instabilities in solid propellant rocket motors. This understanding is needed to develop practical methods for designing motors that do not exhibit such instabilities. The flow turning loss results from the interaction of the flow of combustion products leaving the surface of the propellant with the acoustic field in an unstable motor. While state of the art solid rocket stability models generally account for the flow turning loss, its magnitude and characteristics have never been fully investigated. This thesis describes a combined theoretical, numerical, and experimental investigation of the flow turning loss and its dependence upon various motor design and operating parameters. First, a one dimensional acoustic stability equation that verifies the existence of the flow turning loss was derived for a chamber with constant mean pressure and temperature. The theoretical development was then extended to include the effects of mean temperature gradients to accommodate combustion systems in which mean temperature gradients and heat losses are significant. These analyses provided the background and expressions necessary to guide an experimental study. The relevant equations were then solved for the developed experimental setup to predict the behavior of the flow turning loss and the other terms of the developed acoustic stability equation. This was followed by and experimental study in which the flow turning region of an unstable solid propellant rocket motor was simulated. The setup was used, with and without combustion, to determine the dependence of the flow turning loss upon operating conditions. These studies showed that the flow turning loss strongly depends upon the gas velocity at the propellant surface and the location of the flow turning region relative to the standing acoustic wave. The flow turning loss measured in the

  13. An electrochemical cell for the efficient turn around of wafer working electrodes

    Science.gov (United States)

    Wozniak, Nicholas R.; Frey, Alyssa A.; Osterbur, Lucas W.; Boman, Timothy S.; Hampton, Jennifer R.

    2010-03-01

    We present a new design for an electrochemical cell for use with wafer working electrodes. The key feature of the design is the use of half turn thumb screws to form a liquid-tight seal between an o-ring and the sample surface. The assembly or disassembly of the cell requires a half turn of each thumb screw, which facilitates the quick turn around of wafer samples. The electrochemical performance of the cell is demonstrated by cyclic voltammetry and double step chronoamperometry measurements of the ferricyanide/ferrocyanide couple.

  14. A novel method for calculating the energy cost of turning during running

    Directory of Open Access Journals (Sweden)

    Hatamoto Y

    2013-05-01

    Full Text Available Yoichi Hatamoto,1 Yosuke Yamada,2 Tatsuya Fujii,3 Yasuki Higaki,3 Akira Kiyonaga,3 Hiroaki Tanaka31Graduate School of Sports and Health Science, Fukuoka University, Nanakuma Jonan-ku Fukuoka, Japan; 2The Fukuoka University Institute for Physical Activity, Nanakuma Jonan-ku Fukuoka, Japan; 3Faculty of Sports and Health Science, Fukuoka University, Nanakuma Jonan-ku Fukuoka, JapanAbstract: Although changes of direction are one of the essential locomotor patterns in ball sports, the physiological demand of turning during running has not been previously investigated. We proposed a novel approach by which to evaluate the physiological demand of turning. The purposes of this study were to establish a method of measuring the energy expenditure (EE of a 180° turn during running and to investigate the effect of two different running speeds on the EE of a 180° turn. Eleven young, male participants performed measurement sessions at two different running speeds (4.3 and 5.4 km/hour. Each measurement session consisted of five trials, and each trial had a different frequency of turns. At both running speeds, as the turn frequency increased the gross oxygen consumption (V · O2 also increased linearly (4.3 km/hour, r = 0.973; 5.4 km/hour, r = 0.996. The V · O2 of a turn at 5.4 km/hour (0.55 [SD 0.09] mL/kg was higher than at 4.3 km/hour (0.34 [SD 0.13] mL/kg (P < 0.001. We conclude that the gross V · O2 of running at a fixed speed with turns is proportional to turn frequency and that the EE of a turn is different at different running speeds. The Different Frequency Accumulation Method is a useful tool for assessing the physiological demands of complex locomotor activity.Keywords: energy expenditure, turning, turn frequency, running speed, V · O2, heart rate

  15. Novel T-Z source inverter with high voltage gain and reduced transformer turn ratio

    DEFF Research Database (Denmark)

    Mostaan, Ali; Sharifi Malfejani, Saeed; Soltani, Mohsen

    2015-01-01

    Novel voltage source inverter based on the Z source inverter structure is introduced in this paper. In this new inverter, two inductors of the impedance network in conventional Z source inverter are replaced with two transformers or coupled inductors, but unlike the T-Z source inverter that it......'s voltage gain is raised with increasing the transformers turn ratio, the voltage gain in the proposed inverter is raised with lowering the transformer turn ratio. Therefore, transformers with lower turn ratio are required in the proposed inverter in compare with T- Z source inverter that can lead to lower...

  16. Efficiency analysis of the speed turns in the crawl stroke swimming.

    Directory of Open Access Journals (Sweden)

    Savchenko M.I.

    2011-02-01

    Full Text Available Contemporary approaches to improving technique of the speed in the crawl stroke swimming, namely roll-forward turn were considered in the paper. The performance efficiency is defined by the time covering 15 meter distance. The students of the sports mastering group aged 16-20 took part in the experiment. The video recordings of the Ukrainian, European and World Championships and Deflympic Games, and also chronometration during the department trainings served as the experimental data. The research showed that white improving the technical level of turns performance, the attention should be paid to the exact performance of all the elements of the turns.

  17. Tool life of diamond inserts after laser assisted turning of cemented carbides

    Directory of Open Access Journals (Sweden)

    Kieruj Piotr

    2017-01-01

    Full Text Available The paper presents results and discussion on parameters influence on tool life when turning laser cladded cemented carbides under laser assisted machining (LAM conditions. The layers are known as Technolase 30S. This material is widely recognized as hard-to-cut. The experimental investigation was carried out with diamond inserts. The laser power density, feed rate and laser scanning speed were analysed. Flank wear (VBc indicator was measured and cutting tool life was calculated. It was proved that Technolase 30S can be machined with LAM technology. The laser enhanced turning is more efficient than conventional turning and grinding.

  18. Tight turns

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    The Italian National Institute for Nuclear Physics (INFN) has successfully tested the first model of a new fast-ramping curved dipole magnet. This is great news for CERN, which sees the advance as holding potential for the future of the SPS.   The first model of a new fast-ramping curved dipole magnet being prepared for cryogenic testing at the LASA laboratory (INFN Milano, Italy). On 16 July INFN introduced an innovative dipole magnet. With a length of some 4 metres, it can produce a 4.5 Tesla magnetic field and achieve a tighter bend than ever before (the bending radius has been squeezed to a remarkable 66.7 metres). This new magnet was designed in the first instance for GSI’s SIS300 synchrotron (in Germany), which will require 60 dipoles of this type. "Achieving such a tight bend demanded a major R&D effort," stressed Pasquale Fabbricatore, the spokesman of the INFN collaboration responsible for the magnet’s development. "We had to not o...

  19. Very High Load Capacity Air Bearing Spindle for Large Diamond Turning Machines Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Diamond turning is able to produce highly aspheric visible quality optics which can be easily aligned. Very large optical systems such as OWL and EUSO are impossible...

  20. State-of-the-art literature review on permissive/protected left-turn control.

    Science.gov (United States)

    2013-06-01

    In spring 2010, the Illinois Department of Transportation initiated an areawide implementation to integrate the : flashing yellow arrow as the display for the left-turn permissive interval at more than 100 intersections operating : with protected/per...

  1. Vehicle kinematics in turns and the role of cornering lamps in driver vision.

    Science.gov (United States)

    2010-11-01

    "SAE Recommended Practice J852 and ECE Regulations 119 and 48 for cornering lamps : were compared. Photometric points described in each specification were then compared : to naturalistic low-speed turn trajectories produced by 87 drivers. Future loca...

  2. The right way to kiss: directionality bias in head-turning during kissing

    National Research Council Canada - National Science Library

    A K M Rezaul Karim; Michael J Proulx; Alexandra A de Sousa; Chhanda Karmaker; Arifa Rahman; Fahria Karim; Naima Nigar

    2017-01-01

    .... We investigated head-turning bias in both kiss initiators and kiss recipients for lip kissing, and took into consideration differences due to sex and handedness, in 48 Bangladeshi heterosexual married couples...

  3. Method And Apparatus For Reducing Sample Dispersion In Turns And Junctions Of Micro-Channel Systems

    Science.gov (United States)

    Griffiths, Stewart K. , Nilson, Robert H.

    2004-05-11

    What is disclosed pertains to improvement in the performance of microchannel devices by providing turns, wyes, tees, and other junctions that produce little dispersion of a sample as it traverses the turn or junction. The reduced dispersion results from contraction and expansion regions that reduce the cross-sectional area over some portion of the turn or junction. By carefully designing the geometries of these regions, sample dispersion in turns and junctions is reduced to levels comparable to the effects of ordinary diffusion. The low dispersion features are particularly suited for microfluidic devices and systems using either electromotive force, pressure, or combinations thereof as the principle of fluid transport. Such microfluidic devices and systems are useful for separation of components, sample transport, reaction, mixing, dilution or synthesis, or combinations thereof.

  4. 77 FR 4989 - Turning Point Solar LLC: Notice of Availability of an Environmental Assessment

    Science.gov (United States)

    2012-02-01

    ... photovoltaic panels mounted on fixed solar racking equipment and the construction of access roads, a powerhouse...) ground- mounted solar photovoltaic generating facility in Noble County, Ohio. Turning Point Solar LLC is...

  5. L&D Manual Turn Lane Storage Validation/Update : Executive Summary Report

    Science.gov (United States)

    2012-08-01

    The formation of queues on a highway facility is a sign of the presence of operationally : inefficient sections of the facility. Queuing occurs at intersections in large part due to overflow : or inadequacy of turn bays, inadequate capacity, or poor ...

  6. Turn-key Near-Infrared Photon-Counting Detector Module for LIDAR Applications Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to design and deliver a turn-key photon counting detector module for near-infrared wavelengths, based on large-area InGaAs/InP avalanche photodiodes...

  7. A Modest POPSCI Proposal: Turn The ISS Into A $2 Million-A-Night Space Hotel

    National Research Council Canada - National Science Library

    Dawn Stover

    2004-01-01

    If the International Space Station (ISS) is completed in 2010 and then becomes obsolete due to rapidly advancing space exploration capabilities, NASA should turn the ISS into the world's most exclusive hotel...

  8. Spatiotemporal and Kinematic Parameters Relating to Oriented Gait and Turn Performance in Patients with Chronic Stroke

    National Research Council Canada - National Science Library

    Bonnyaud, Céline; Pradon, Didier; Vuillerme, Nicolas; Bensmail, Djamel; Roche, Nicolas

    2015-01-01

    ... and therefore may help to guide rehabilitation. The aim of this study was thus to determine the spatiotemporal and kinematic parameters which were most related to the walking and turning sub-tasks of TUG performance in stroke patients...

  9. Study on BTT Coordinated Turn Autopilot Design for Reentry Gliding Vehicle

    Science.gov (United States)

    Qiang, Li; Yongtao, Shui; Yonghai, Wang; Gang, Wang; Xuguo, Qin

    2017-09-01

    Two-loop acceleration yaw-autopilot with a PI compensator and the engineering approximation of sideslip angle rate feedback for autopilot inner-loop are put forward accounted for BTT coordinated turn control of reentry gliding vehicle. The effect of turning acceleration to body-frame yaw channel is analyzed deeply, two-loop acceleration yaw-autopilot with a PI compensator is advanced to ensure system rapidity and stability based on minimum output by turning acceleration. The convergence essence of sideslip angle rate feedback is presented, furthermore, the engineering implementation composed by yaw angle rate and feedforward compensator is presented. Finally, the simulation results show that the autopilot design can make sideslip angle to be zero fast, improve the performance of coordinated turn. The design has certain robustness and application value.

  10. Emotions and Social Sciences in 20th century: The Prequel of Affective Turn

    Directory of Open Access Journals (Sweden)

    Giazú Enciso Domínguez

    2014-02-01

    Full Text Available The Affective Turn is an innovative movement that is transforming the production of knowledge based on the study of affect and emotion. To understand the current role of emotions, we proposed a 'prequel. Telling what happened with emotions within the social sciences before the Affective Turn, and before the twentieth century. In this work we explain the present from the past, we tell the story before The History, we pay a debt to a previous work: The Affective Turn. We articulate the prequel through seven approaches: Socialconstructionism, Discursive Social Psychology, Cultural Studies of Emotions, Emocionologies, Interpretative Sociology, Sociolinguistic of Emotions and Feminist Studies of emotions. We review the interests of each approach, their schools, their past, and give hints about not only the present but the future(s of the Affective Turn, in social science and academy as well.

  11. Decision tree learning for detecting turning points in business process orientation: a case of Croatian companies

    Directory of Open Access Journals (Sweden)

    Ljubica Milanović Glavan

    2015-03-01

    Full Text Available Companies worldwide are embracing Business Process Orientation (BPO in order to improve their overall performance. This paper presents research results on key turning points in BPO maturity implementation efforts. A key turning point is defined as a component of business process maturity that leads to the establishment and expansion of other factors that move the organization to the next maturity level. Over the past few years, different methodologies for analyzing maturity state of BPO have been developed. The purpose of this paper is to investigate the possibility of using data mining methods in detecting key turning points in BPO. Based on survey results obtained in 2013, the selected data mining technique of classification and regression trees (C&RT was used to detect key turning points in Croatian companies. These findings present invaluable guidelines for any business that strives to achieve more efficient business processes.

  12. Diamond Turned Super Alloy Mandrel for Slump Forming X-Ray Observatory (IXO) Mirrors Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Diamond turning is proven to be able to quickly produce highly aspheric grazing incidence optical contours to visible wavelength tolerances with extremely smooth...

  13. Aerodynamics in arbitrarily accelerating frames: application to high-g turns

    CSIR Research Space (South Africa)

    Gledhill, Irvy MA

    2010-09-01

    Full Text Available Fifth-generation missilies accelerate up to 100 g in turns, and higher accelerations are expected as agility increases. The authors have developed the theory of aerodynamics for arbitrary accelerations, and have validated modelling in a...

  14. Aerodynamics in arbitrarily accelerating frames: application to high-g turns

    CSIR Research Space (South Africa)

    Gledhill, Irvy MA

    2010-09-01

    Full Text Available Fifth-generation missiles accelerate up to 100 g in turns, and higher accelerations are expected as agility increases. The auhtors have developed the theory of aerodynamics for arbitrary accelerations, and have validated modelling in a Computational...

  15. Turning points in the progression of obsessive relational intrusion and stalking.

    Science.gov (United States)

    Mumm, Sai Sato; Cupach, William R

    2010-01-01

    This study examined the critical events defining the temporal progression of unwanted relationship pursuit. Retrospective interviews elicited the experiences of 42 victims of obsessive relational intrusion (ORI) and its extreme manifestation, stalking. Participants described turning points within their ORI experiences, and constructed graphs representing the progression of turning points over time in terms of changes in perceived severity. Inductive data analysis revealed 17 distinct turning point types. Some turning point types were associated with increases in ORI severity and others were associated with decreases. Five temporal trajectories of ORI progression also were identified. Results indicate that ORI does not necessarily progress along linear and continuous paths. Some findings support coping advice commonly given to victims of ORI and stalking.

  16. Zwrot w myśli Heideggera (THE TURN IN HEIDEGGER'S THOUGHT

    Directory of Open Access Journals (Sweden)

    Małgorzata Kwietniewska

    2007-06-01

    Full Text Available The main problem discussed in the article is the concept of the turn in Heidegger's philosophy. Numerous commentators have interpreted the turn as a mark of a radical change in the philosopher's interests after 1930. Heidegger, however, often seems to imply that the concept refers both to his own discourse and to a supraindividual change in the very metaphysical thought. This difficulty can be resolved only after a careful examination of Heidegger's enterprise of 'overcoming metaphysics' as well as his putting into question of the traditional philosophical paradigm. It is this perspective that allows the speculative meaning of the term 'turn' to be clearly seen. The meaning reveals the following paradox: that the turn both is and is not. In a way, the paradox forms a credo of Heidegger's postmetaphysical work.Other author's publications:

  17. Inter-hospital communications and transport: turning one-way funnels into two-way networks

    National Research Council Canada - National Science Library

    Rokos, Ivan C; Sanddal, Nels D; Pancioli, Arthur M; Wolff, Catherine; Gaieski, David F

    2010-01-01

    ... of patients between and among acute care settings. The subtitle, "Turning Funnels Into Two-way Networks," is descriptive of the approach that the workgroup took by exploring how and when smaller facilities in suburban, rural, and frontier areas...

  18. Suppressing the turn-off-induced pulsations in VCSELs using an elevated oxide-layer structure.

    Science.gov (United States)

    Kim, Taeyong; Kim, Sang-Bae

    2010-01-18

    We have demonstrated that, in elevated oxide-layer vertical-cavity surface-emitting lasers (VCSELs) where the spacing between 1-lambda cavity and oxide layer is 9lambda/4, a variety of turn-off-induced abnormalities such as secondary pulsations, bumps and tails is effectively suppressed. Compared are turn-off transient responses of conventional and elevated oxide-layer VCSELs with the oxide-aperture diameter of approximately 6.6 microm. The "on"- and "off"-current dependence of the turn-off-induced transient responses and bit rate dependence of the timing jitters show that the elevated oxide-layer structure effectively suppresses the turn-off-induced pulsations to less than half of the conventional one, which enables the VCSEL transmitter to operate without deleterious effects by the turnoff-induced pulsation.

  19. Same menu, seperate tables : the institutionalist turn in political science and the study of European integration

    OpenAIRE

    Aspinwall, Mark D.; Schneider, Gerald

    2000-01-01

    Recent research on European integration has largely profited from the institutionalist turn in political science. Theoretical progress has, however, been hampered by the diverse understandings of this new research tradition. This paper tries to tackle the conceptual diversity in a positive way. We first analyze the neo-institutionalist turn in political science and European studies and then move on to a detailed analysis and comparison of the three competing approaches sociological, histori...

  20. Is there a spillover effect of a right turn on red permission for bicyclists?

    OpenAIRE

    De Ceunynck, Tim; Daniels, Stijn; Vanderspikken, B.; Brijs, Kris; Hermans, Elke; Brijs, Tom; Wets, Geert

    2014-01-01

    Some countries allow bicyclists to perform a right turn on red (RTOR) at a number of signalized intersections to promote cycling by reducing the required physical effort and trip time. Implementation of this law could lead to both local and supralocal effects on road safety. Using an experimental survey approach, this study explores whether a so-called ‘spillover effect’ of the measure can be expected. This effect implies that allowing bicyclists to turn right on red at some places causes ...

  1. Cutting Mechanics and Surface Finish for Turning with Differently Shaped CBN Tools

    OpenAIRE

    Żak Krzysztof

    2017-01-01

    In this paper, the basic cutting characteristics such as cutting forces, cutting power and its distribution, specific cutting energies were determined taking into account variable tool corner radius ranging from 400 to 1200 µm and constant cutting parameters typical for hard turning of a hardened 41Cr4 alloy steel of 55±1 HRC hardness. Finish turning operations were performed using chamfered CBN tools. Moreover, selected roughness profiles produced for different tool corner radius were compar...

  2. Interconversion of molecular face-rotating polyhedra through turning inside out.

    Science.gov (United States)

    Wang, Yu; Fang, Hongxun; Zhang, Wei; Zhuang, Yongbin; Tian, Zhongqun; Cao, Xiaoyu

    2017-08-08

    We report the post-synthesis interconversion of two enantiomeric organic cages through turning inside out. By scrutinizing the thermodynamics and kinetics, we are able to control the racemization rate by various reaction conditions and reveal that the turning-inside-out interconversion is realized through a partial disassembly pathway. The kinetics investigation also provides insight into the dynamic essence of imine chemistry using different solvents and catalysts.

  3. Turn Motors Off When Not in Use - Motor Tip Sheet #10

    Energy Technology Data Exchange (ETDEWEB)

    None

    2008-07-01

    Motors use no energy when turned off. Reducing motor operating time by just 10% usually saves more energy than replacing a standard efficiency motor with a NEMA Premium® efficiency motor. In fact, given that 97% of the life cycle cost of purchasing and operating a motor is energy-related, turning a motor off 10% of the time could reduce energy costs enough to purchase three new motors.

  4. As the Egg Turns: Monitoring Egg Attendance Behavior in Wild Birds Using Novel Data Logging Technology

    OpenAIRE

    Shaffer, Scott A.; Clatterbuck, Corey A.; Kelsey, Emma C.; Naiman, Alex D.; Young, Lindsay C.; VanderWerf, Eric A.; Warzybok, Pete; Bradley, Russell; Jahncke, Jaime; Bower, Geoff C.

    2014-01-01

    Egg turning is unique to birds and critical for embryonic development in most avian species. Technology that can measure changes in egg orientation and temperature at fine temporal scales (1 Hz) was neither readily available nor small enough to fit into artificial eggs until recently. Here we show the utility of novel miniature data loggers equipped with 3-axis (i.e., triaxial) accelerometers, magnetometers, and a temperature thermistor to study egg turning behavior in free-ranging birds. Art...

  5. Educating the community about violence through a gun turn-in program.

    Science.gov (United States)

    Yurk, R; Jaramillo, L; Erwin, L L; Rendleman, N J

    2001-10-01

    The Ceasefire Oregon gun turn in program was initiated to educate the community regarding violence through a gun turn-in program with voluntary surrender of firearms, educational efforts about violence, and institution of public safety policies. The community board of directors was composed of multiple community leadership organizations. A multi-intervention education, outreach and media program consisting of distribution of brochures, presentations, school education programs, and workshops was implemented throughout the year in addition to the gun turn-in program held in May for two days. A survey was administered to participants in the program at the turn-in sites. The cumulative total for guns turned in years 1994 to 1999 was 4,345. Half of the respondents reported possession of a gun at home. The most common reasons for participating in the gun turn in were obtaining gift certificates and not wanting the gun any more. A successful community grassroots program, Ceasefire Oregon has shown sustainability over six years with increased participation secondary to education, advertising and incentives. Community and statewide efforts can assist with building the infrastructure for programs, however more tools for quantitative performance program evaluation would facilitate measuring the impact on the community.

  6. Effect of Brief Northward Turning in IMF Bz in an MHD Simulation

    Science.gov (United States)

    Pham, K. H.; Lopez, R. E.; Bruntz, R. J.

    2015-12-01

    While the solar wind is typically highly variable, most MHD simulation studies use idealized steady state conditions to study the magnetosphere-ionosphere coupling. To better understand the effect of variable solar wind conditions, we have conducted a variety of numerical experiments using the Lyon-Fedder-Mobarry (LFM) global magnetohydrodynamic simulation. The solar wind input into the LFM simulation has been configured to contain an interplanetary magnetic field (IMF) that starts at a steady southward IMF and suddenly turns northward for a brief period of time before turning back into a steady southward IMF. The height of the brief northward turning and the period of northward turning has been varied for each simulation run. Classically, the period of northward will greatly reduce energy dissipation in the ionosphere. When the northward IMF is flipped back to southward, the reduced dissipation lingers and causes the period of southward immediately following the northward IMF turning to also have less dissipation. With larger northward IMF magnitudes, the dissipation during southward is also correspondingly lower. We will present a detailed analysis of the magnetic topology for the period of southward immediately following the northward IMF turning and discuss a possible cause for this reduction in energy dissipation.

  7. Method and apparatus for reducing sample dispersion in turns and junctions of microchannel systems

    Science.gov (United States)

    Griffiths, Stewart K.; Nilson, Robert H.

    2001-01-01

    The performance of microchannel devices is improved by providing turns, wyes, tees, and other junctions that produce little dispersions of a sample as it traverses the turn or junction. The reduced dispersion results from contraction and expansion regions that reduce the cross-sectional area over some portion of the turn or junction. By carefully designing the geometries of these regions, sample dispersion in turns and junctions is reduced to levels comparable to the effects of ordinary diffusion. A numerical algorithm was employed to evolve low-dispersion geometries by computing the electric or pressure field within candidate configurations, sample transport through the turn or junction, and the overall effective dispersion. These devices should greatly increase flexibility in the design of microchannel devices by permitting the use of turns and junctions that do not induce large sample dispersion. In particular, the ability to fold electrophoretic and electrochrornatographic separation columns will allow dramatic improvements in the miniaturization of these devices. The low-lispersion devices are particularly suited to electrochromatographic and electrophoretic separations, as well as pressure-driven chromatographic separation. They are further applicable to microfluidic systems employing either electroosrnotic or pressure-driven flows for sample transport, reaction, mixing, dilution or synthesis.

  8. Safety evaluation of signalized intersections with left-turn waiting area in China.

    Science.gov (United States)

    Jiang, Xinguo; Zhang, Guopeng; Bai, Wei; Fan, Wenbo

    2016-10-01

    In recent years the metropolitans in China have seen the surging installations of the left-turn waiting area (LWA) at the signalized intersections. The design allows the left-turning vehicles to enter the intersection at the onset of the through green phase (of the same approach) and wait for the exclusive left-turn signal at the LWA. The LWA layout can effectively reduce the probability of stranded and queue overflow of the left-turn vehicles, but no study is conducted yet to assess the safety performance of the signalized intersections with LWA. The paper adopts the traffic conflict technique (represented by post-encroachment time), compares the discrepancy of conflict types between intersections with LWA and without, and develops the severity models to identify the contributing factors for the left-turn conflicts. Results demonstrate that the left-turn volume, driving outside the LWA, running red light, the presence of secondary conflicts, and the rear-end conflicts significantly increase the severities of traffic conflicts at the LWA. The findings serve to provide recommendations to revise the current design standard of the LWA (GB5768-2009) and consequently improve the safety operations of signalized intersections with LWA in China. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. Structure of the K-turn U4 RNA: a combined NMR and SANS study.

    Science.gov (United States)

    Falb, Melanie; Amata, Irene; Gabel, Frank; Simon, Bernd; Carlomagno, Teresa

    2010-10-01

    K-turn motifs are universal RNA structural elements providing a binding platform for proteins in several cellular contexts. Their characteristic is a sharp kink in the phosphate backbone that puts the two helical stems of the protein-bound RNA at an angle of 60°. However, to date no high-resolution structure of a naked K-turn motif is available. Here, we present the first structural investigation at atomic resolution of an unbound K-turn RNA (the spliceosomal U4-Kt RNA) by a combination of NMR and small-angle neutron scattering data. With this study, we wish to address the question whether the K-turn structural motif assumes the sharply kinked conformation in the absence of protein binders and divalent cations. Previous studies have addressed this question by fluorescence resonance energy transfer, biochemical assays and molecular dynamics simulations, suggesting that the K-turn RNAs exist in equilibrium between a kinked conformation, which is competent for protein binding, and a more extended conformation, with the population distribution depending on the concentration of divalent cations. Our data shows that the U4-Kt RNA predominantly assumes the more extended conformation in the absence of proteins and divalent cations. The internal loop region is well structured but adopts a different conformation from the one observed in complex with proteins. Our data suggests that the K-turn consensus sequence does not per se code for the kinked conformation; instead the sharp backbone kink requires to be stabilized by protein binders.

  10. Composting of tobacco plant waste by manual turning and forced aeration system

    Directory of Open Access Journals (Sweden)

    Nonglak Saithep

    2009-05-01

    Full Text Available The efficiency of tobacco plant waste composting, by the manual turning and the forced aeration system, was compared. Tobacco plant waste, cow manure, urea fertiliser, and a compost inoculum mixture at a 100:10:0.2:0.01 ratio respectively, with 60% (w/v moisture content, were set up in piling forms. The piles of the manual turning system were provided with turning aeration by hand at intervals of 7 days during the composting process. For the forced aeration system, each pile was aerated by a 3-HP air pump with a flow rate of 19 litres min-1 for 15 minutes every morning and evening. The completely randomised design of turned and force-aerated piles was performed in triplicate. The composting activity of both systems during the composting period was measured by several parameters: temperature, pH, moisture content, C/N ratio, growth of microorganisms, cellulase activity, and nicotine degradation in the set-up piles. Both systems had similar temperature, pH, and moisture content conditions in the piles during the composting process. However, the forced aeration system was more advantageous for the growth of mesophilic and thermophilic microorganisms, for cellulase activity from cellulase-producing microorganisms, and for nicotine degradation, when compared to the manual turning system. In conclusion, the forced aeration system was more efficient than the manual turning system in composting and is a viable alternative method for the composting process.

  11. A prospective randomized study of the efficacy of "Turning Point," an inpatient violence intervention program.

    Science.gov (United States)

    Loveland-Jones, Catherine; Ferrer, Lucas; Charles, Scott; Ramsey, Frederick; van Zandt, Andrea; Volgraf, Jill; Santora, Thomas; Pathak, Abhijit; Dujon, Jay; Sjoholm, Lars; Rappold, Joseph; Goldberg, Amy

    2016-11-01

    From 2002 to 2011, there were more than 17,000 shootings in Philadelphia. "Turning Point," Temple University Hospital's inpatient violence intervention program, takes advantage of the teachable moment that occurs after violent injury. In addition to receiving traditional social work services, Turning Point patients watch their trauma bay resuscitation video and a movie about violence, meet with a gunshot wound survivor and an outpatient case manager, and also undergo psychiatric assessment. The purpose of this study was to determine the efficacy of Turning Point in changing attitudes toward guns and violence among victims of penetrating trauma. This prospective randomized study was conducted from January 2012 to January 2014. Patients who sustained a gunshot or stab wound were randomized to standard of care, which involved traditional social work services only, or Turning Point. The Attitudes Toward Guns and Violence Questionnaire was administered to assess attitude change. Analysis was performed with repeated-measures analysis of variance. A p violence. Turning Point is effective in changing attitudes toward guns and violence among victims of penetrating trauma. Longer follow-up is necessary to determine if this program can truly be a turning point in patients' lives. Therapeutic/care management study, level II.

  12. Phosphonate O-deethylation of [4-(4-bromo-2-cyano-phenylcarbamoyl) benzyl]-phosphonic acid diethyl ester, a lipoprotein lipase-promoting agent, catalyzed by cytochrome P450 2C8 and 3A4 in human liver microsomes.

    Science.gov (United States)

    Morioka, Yujiro; Otsu, Makiko; Naito, Shinsaku; Imai, Teruko

    2002-03-01

    NO-1886 ([4-(4-bromo-2-cyano-phenylcarbamoyl) benzyl]-phosphonic acid diethyl ester) increases lipoprotein lipase activity, resulting in a reduction in plasma triglycerides and an increase in high-density lipoprotein cholesterol. The metabolism of NO-1886 in human liver was investigated in the present study. Ester cleavage of NO-1886 from diethyl phosphonate to monoethyl phosphonate was the major metabolic pathway catalyzed by cytochrome P450. In addition, the minor metabolic pathway in human liver was the hydrolysis of the amide bond of NO-1886 by a specific cytosolic esterase. Eadie-Hofstee plots of phosphonate O-deethylation of NO-1886 in human liver microsomes showed a biphasic curve, indicating low- and high-K(m) components. Inhibition experiments with chemical inhibitors and antibodies against various cytochrome P450 isoforms suggested the involvement of CYP2C8 and CYP3A in the phosphonate O-deethylation. Recombinant CYP3A4 and CYP2C8 expressed in baculovirus-infected insect cells and human lymphoblastoid cells exhibited a high activity for phosphonate O-deethylation of NO-1886. The recombinant cytochrome P450 enzymes indicated that CYP2C8 and CYP3A4 were responsible for the low- and high-K(m) components in human liver microsomes, respectively. The selectivity of CYP2C8 in catalyzing phosphonate O-deethylation indicates that coadministration of drugs that are metabolized by the same enzyme requires careful consideration.

  13. Non-uniform ramping losses and thermal optimization with turn-to-turn resistivity grading in a (RE)Ba2Cu3Ox magnet consisting of multiple no-insulation pancake coils

    Science.gov (United States)

    Wang, Yawei; Zhang, Min; Yuan, Weijia; Hong, Zhiyong; Jin, Zhijian; Song, Honghai

    2017-08-01

    This paper presents a study on the ramping losses of a high temperature superconductor (HTS) magnet consisting of multiple no-insulation (NI) (RE)Ba2Cu3Ox coils. The (RE)Ba2Cu3Ox (REBCO) conductor is the second generation HTS thin tape, where RE stands for rare-earth. During a ramping operation of the NI HTS magnet, losses are generated both across turn-to-turn resistances and inside superconducting layers. The former comes with radial current, which is called "turn-to-turn loss;" the latter one is induced by flux creep and jump, called "magnetization loss." The modeling and experimental studies on the ramping losses have been reported on single NI pancake coils in the previous part. In a HTS magnet consisting of multiple NI coils, the electromagnetic coupling between coils has a considerable influence on the distribution of ramping losses. Here, the experimentally validated model is used to investigate a HTS magnet consisting of 14 single pancake REBCO coils. The results show that both the turn-to-turn loss and the magnetization loss present a significant non-uniform distribution among the coils. The highest turn-to-turn loss occurs on the middle coils of the magnet, while the highest magnetization loss happens on the end coils. The non-uniform distribution of ramping losses can result in a considerable temperature difference among coils in the NI HTS magnet. It leads to an additional quench risk on the magnet and requires more attention in design. The distribution of the turn-to-to-turn loss can be optimized by adjusting the turn-to-turn resistivity. A much more uniform turn-to-turn loss distribution among coils is achieved by applying a graded turn-to-turn resistivity on the multiple coils.

  14. Extended turn construction and test question sequences in the conversations of three speakers with agrammatic aphasia

    Science.gov (United States)

    Beckley, Firle; Best, Wendy; Johnson, Fiona; Edwards, Susan; Maxim, Jane

    2013-01-01

    The application of Conversation Analysis (CA) to the investigation of agrammatic aphasia reveals that utterances produced by speakers with agrammatism engaged in everyday conversation differ significantly from utterances produced in response to decontextualised assessment and therapy tasks. Early studies have demonstrated that speakers with agrammatism construct turns from sequences of nouns, adjectives, discourse markers and conjunctions, packaged by a distinct pattern of prosody. This article presents examples of turn construction methods deployed by three people with agrammatism as they take an extended turn, in order to recount a past event, initiate a discussion or have a disagreement. This is followed by examples of sequences occurring in the talk of two of these speakers that result in different, and more limited, turn construction opportunities, namely “test” questions asked in order to initiate a new topic of talk, despite the conversation partner knowing the answer. The contrast between extended turns and test question sequences illustrates the effect of interactional context on aphasic turn construction practices, and the potential of less than optimal sequences to mask turn construction skills. It is suggested that the interactional motivation for test question sequences in these data are to invite people with aphasia to contribute to conversation, rather than to practise saying words in an attempt to improve language skills. The idea that test question sequences may have their origins in early attempts to deal with acute aphasia, and the potential for conversation partnerships to become “stuck” in such interactional patterns after they may have outlived their usefulness, are discussed with a view to clinical implications. PMID:23848370

  15. Dance for Parkinson's-The effects on whole body co-ordination during turning around.

    Science.gov (United States)

    Hulbert, Sophia; Ashburn, Ann; Roberts, Lisa; Verheyden, Geert

    2017-06-01

    To investigate the effects of ballroom and Latin American dancing classes on turning in people with Parkinson's. This study employed a randomised, controlled, experimental design. Dance classes were performed in a community dance centre in Southern England and all assessments took place a gait laboratory. Twenty-seven people with mild-moderate Parkinson's participated. Participants were randomly allocated to receive either 20, 1-h dancing classes over 10 weeks (n=15), or a 'usual care' control group (n=12). Twelve, 180° on-the-spot turns to the predicted/un-predicted and preferred/un-preferred direction were analysed for each participant, using 3-dimensional motion analysis before and after the intervention period, alongside clinical measures. Movement of the head, pelvis, and feet during turning in people with Parkinson's are affected by dancing with tighter coupling of body segments. Significant 4-way interactions between the groups, over time and turn style, with longer latency of the head (p=0.008) and greater rotation in the pelvis (p=0.036), alongside a trend of slower movement of the first (p=0.063) and second (p=0.081) foot in controls were shown, with minimal change in dancers. All interactions were affected by the type of turn. No significant differences were found in the centre of mass displacement, turn time or clinical measures. Those who danced were better able to coordinate their axial and perpendicular segments and surprisingly became more 'en bloc' in their turning behaviour, suggesting this may be a beneficial adaptation, rather than a maladaptive result of Parkinson's, as previously suggested. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Suspending the next turn as a form of repair initiation: evidence from Argentine Sign Language

    Directory of Open Access Journals (Sweden)

    Elizabeth eManrique

    2015-09-01

    Full Text Available Practices of other-initiated repair deal with problems of hearing or understanding what another person has said in the fast-moving turn-by-turn flow of conversation. As such, other-initiated repair plays a fundamental role in the maintenance of intersubjectivity in social interaction. This study finds and analyses a special type of other-initiated repair that is used in turn-by-turn conversation in a sign language: Argentine Sign Language (Lengua de Señas Argentina or LSA. We describe a type of response termed a ‘freeze-look’, which occurs when a person has just been asked a direct question: instead of answering the question in the next turn position, the person holds still while looking directly at the questioner. In these cases it is clear that the person is aware of having just been addressed and is not otherwise accounting for their delay in responding (e.g., by displaying a ‘thinking’ face or hesitation, etc.. We find that this behavior functions as a way for an addressee to initiate repair by the person who asked the question. The ‘freeze-look’ results in the questioner ‘re-doing’ their action of asking a question, for example by repeating or rephrasing it. Thus we argue that the ‘freeze-look’ is a practice for other-initiation of repair. In addition, we argue that it is an ‘off-record’ practice, thus contrasting with known on-record practices such as saying ‘Huh?’ or equivalents. The findings aim to contribute to research on human understanding in everyday turn-by-turn conversation by looking at an understudied sign language, with possible implications for our understanding of visual bodily communication in spoken languages as well.

  17. Locomotion pattern and foot pressure adjustments during gentle turns in healthy subjects.

    Science.gov (United States)

    Peyer, Kathrin E; Brassey, Charlotte A; Rose, Kayleigh A; Sellers, William I

    2017-07-26

    People suffering from locomotor impairment find turning manoeuvres more challenging than straight-ahead walking. Turning manoeuvres are estimated to comprise a substantial proportion of steps taken daily, yet research has predominantly focused on straight-line walking, meaning that the basic kinetic, kinematic and foot pressure adaptations required for turning are not as well understood. We investigated how healthy subjects adapt their locomotion patterns to accommodate walking along a gently curved trajectory (radius 2.75m). Twenty healthy adult participants performed walking tasks at self-selected speeds along straight and curved pathways. For the first time for this mode of turning, plantar pressures were recorded using insole foot pressure sensors while participants' movements were simultaneously tracked using marker-based 3D motion capture. During the steady-state strides at the apex of the turn, the mean operating point of the inside ankle shifted by 1 degree towards dorsiflexion and that for the outside ankle shifted towards plantarflexion. The largest change in relative joint angle range was an increase in hip rotation in the inside leg (>60%). In addition, the inside foot was subject to a prolonged stance phase and a 10% increase in vertical force in the posteromedial section of the foot compared to straight-line walking. Most of the mechanical change required was therefore generated by the inside leg with hip rotation being a major driver of the gentle turn. This study provides new insight into healthy gait during gentle turns and may help us to understand the mechanics behind some forms of impairment. Copyright © 2017. Published by Elsevier Ltd.

  18. Suspending the next turn as a form of repair initiation: evidence from Argentine Sign Language

    Science.gov (United States)

    Manrique, Elizabeth; Enfield, N. J.

    2015-01-01

    Practices of other-initiated repair deal with problems of hearing or understanding what another person has said in the fast-moving turn-by-turn flow of conversation. As such, other-initiated repair plays a fundamental role in the maintenance of intersubjectivity in social interaction. This study finds and analyses a special type of other-initiated repair that is used in turn-by-turn conversation in a sign language: Argentine Sign Language (Lengua de Señas Argentina or LSA). We describe a type of response termed a “freeze-look,” which occurs when a person has just been asked a direct question: instead of answering the question in the next turn position, the person holds still while looking directly at the questioner. In these cases it is clear that the person is aware of having just been addressed and is not otherwise accounting for their delay in responding (e.g., by displaying a “thinking” face or hesitation, etc.). We find that this behavior functions as a way for an addressee to initiate repair by the person who asked the question. The “freeze-look” results in the questioner “re-doing” their action of asking a question, for example by repeating or rephrasing it. Thus, we argue that the “freeze-look” is a practice for other-initiation of repair. In addition, we argue that it is an “off-record” practice, thus contrasting with known on-record practices such as saying “Huh?” or equivalents. The findings aim to contribute to research on human understanding in everyday turn-by-turn conversation by looking at an understudied sign language, with possible implications for our understanding of visual bodily communication in spoken languages as well. PMID:26441710

  19. Kinematics of rotation in place during defense turning in the crayfish Procambarus clarkii.

    Science.gov (United States)

    Copp, N H; Jamon, M

    2001-02-01

    The kinematic patterns of defense turning behavior in freely behaving specimens of the crayfish Procambarus clarkii were investigated with the aid of a video-analysis system. Movements of the body and all pereiopods, except the chelipeds, were analyzed. Because this behavior approximates to a rotation in place, this analysis extends previous studies on straight and curve walking in crustaceans. Specimens of P. clarkii responded to a tactile stimulus on a walking leg by turning accurately to face the source of the stimulation. Angular velocity profiles of the movement of the animal's carapace suggest that defense turn responses are executed in two phases: an initial stereotyped phase, in which the body twists on its legs and undergoes a rapid angular acceleration, followed by a more erratic phase of generally decreasing angular velocity that leads to the final orientation. Comparisons of contralateral members of each pair of legs reveal that defense turns are affected by changes in step geometry, rather than by changes in the timing parameters of leg motion, although inner legs 3 and 4 tend to take more steps than their outer counterparts during the course of a response. During the initial phase, outer legs 3 and 4 exhibit larger stance amplitudes than their inner partners, and all the outer legs produce larger stance amplitudes than their inner counterparts during the second stage of the response. Also, the net vectors of the initial stances, particularly, are angled with respect to the body, with the power strokes of the inner legs produced during promotion and those of the outer legs produced during remotion. Unlike straight and curve walking in the crayfish, there is no discernible pattern of contralateral leg coordination during defense turns. Similarities and differences between defense turns and curve walking are discussed. It is apparent that rotation in place, as in defense turns, is not a simple variation on straight or curve walking but a distinct

  20. A-minor tertiary interactions in RNA kink-turns. Molecular dynamics and quantum chemical analysis.

    Science.gov (United States)

    Réblová, Kamila; Šponer, Judit E; Špačková, Naďa; Beššeová, Ivana; Šponer, Jiří

    2011-12-01

    The RNA kink-turn is an important recurrent RNA motif, an internal loop with characteristic consensus sequence forming highly conserved three-dimensional structure. Functional arrangement of RNA kink-turns shows a sharp bend in the phosphodiester backbone. Among other signature interactions, kink-turns form A-minor interaction between their two stems. Most kink-turns possess extended A-minor I (A-I) interaction where adenine of the second A•G base pair of the NC-stem interacts with the first canonical pair of the C-stem (i.e., the receptor pair) via trans-sugar-edge/sugar-edge (tSS) and cis-sugar-edge/sugar-edge (cSS) interactions. The remaining kink-turns have less compact A-minor 0 (A-0) interaction with just one tSS contact. We show that kink-turns with A-I in ribosomal X-ray structures keep G═C receptor base pair during evolution while the inverted pair (C═G) is not realized. In contrast, kink-turns with A-0 in the observed structures alternate G═C and C═G base pairs in sequences. We carried out an extended set (~5 μs) of explicit-solvent molecular dynamics simulations of kink-turns to rationalize this structural/evolutionary pattern. The simulations were done using a net-neutral Na(+) cation atmosphere (with ~0.25 M cation concentration) supplemented by simulations with either excess salt KCl atmosphere or inclusion of Mg(2+). The results do not seem to depend on the treatment of ions. The simulations started with X-ray structures of several kink-turns while we tested the response of the simulated system to base substitutions, modest structural perturbations and constraints. The trends seen in the simulations reveal that the A-I/G═C arrangement is preferred over all three other structures. The A-I/C═G triple appears structurally entirely unstable, consistent with the covariation patterns seen during the evolution. The A-0 arrangements tend to shift toward the A-I pattern in simulations, which suggests that formation of the A-0 interaction is

  1. Effects of auditory cues on gait initiation and turning in patients with Parkinson's disease.

    Science.gov (United States)

    Gómez-González, J; Martín-Casas, P; Cano-de-la-Cuerda, R

    2016-12-08

    To review the available scientific evidence about the effectiveness of auditory cues during gait initiation and turning in patients with Parkinson's disease. We conducted a literature search in the following databases: Brain, PubMed, Medline, CINAHL, Scopus, Science Direct, Web of Science, Cochrane Database of Systematic Reviews, Cochrane Library Plus, CENTRAL, Trip Database, PEDro, DARE, OTseeker, and Google Scholar. We included all studies published between 2007 and 2016 and evaluating the influence of auditory cues on independent gait initiation and turning in patients with Parkinson's disease. The methodological quality of the studies was assessed with the Jadad scale. We included 13 studies, all of which had a low methodological quality (Jadad scale score≤2). In these studies, high-intensity, high-frequency auditory cues had a positive impact on gait initiation and turning. More specifically, they 1) improved spatiotemporal and kinematic parameters; 2) decreased freezing, turning duration, and falls; and 3) increased gait initiation speed, muscle activation, and gait speed and cadence in patients with Parkinson's disease. We need studies of better methodological quality to establish the Parkinson's disease stage in which auditory cues are most beneficial, as well as to determine the most effective type and frequency of the auditory cue during gait initiation and turning in patients with Parkinson's disease. Copyright © 2016 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  2. Reduced turning frequency and delayed poultry manure addition reduces N loss from sugarcane compost.

    Science.gov (United States)

    Bryndum, S; Muschler, R; Nigussie, A; Magid, J; de Neergaard, A

    2017-07-01

    Composting is an effective method to recycle biodegradable waste as soil amendment in smallholder farming systems. Although all essential plant nutrients are found in compost, a substantial amount of nitrogen is lost during composting. This study therefore investigated the potential of reducing N losses by (i) delaying the addition of nitrogen-rich substrates (i.e. poultry manure), and (ii) reducing the turning frequency during composting. Furthermore, we tested the effect of compost application method on nitrogen mineralization. Sugarcane-waste was composted for 54days with addition of poultry manure at the beginning (i.e. early addition) or after 21days of composting (delayed addition). The compost pile was then turned either every three or nine days. Composts were subsequently applied to soil as (i) homogeneously mixed, or (ii) stratified, and incubated for 28days to test the effect of compost application on nitrogen mineralization. The results showed that delayed addition of poultry manure reduced total nitrogen loss by 33% and increased mineral nitrogen content by >200% compared with early addition. Similarly, less frequent turning reduced total N loss by 12% compared with frequent turning. Stratified placement of compost did not enhance N mineralization compared to a homogeneous mixing. Our results suggested that simple modifications of the composting process (i.e. delayed addition and/or turning frequency) could significantly reduce N losses and improve the plant-nutritional value of compost. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Effect of the starting and turning performances on the subsequent swimming parameters of elite swimmers.

    Science.gov (United States)

    Veiga, Santiago; Roig, Andreu

    2017-03-01

    In the present research, we examined the effect of the starting and turning performances on the subsequent swimming parameters by (1) comparing the starting and turning velocities with the swimming parameters on the emersion and mid-pool segments and (2) by relating the individual behaviour of swimmers during the start and turns with subsequent behaviour on each swimming lap. One hundred and twelve 100 m performances on the FINA 2013 World Swimming Championships were analysed by an image-processing system (InThePool 2.0®). At the point of the start emersion, the swimming parameters of the 100-m elite swimmers were substantially greater than the mid-pool parameters, except on the breaststroke races. On the other hand, no diminution in the swimming parameters was observed between the turn emersion and the mid-pool swimming, except on the butterfly and backstroke male races. Changes on the surface swimming kinematics were not generally related to the starting or turning parameters, although male swimmers who develop faster starts seem to achieve faster velocities at emersion. Race analysts should be aware of a transfer of momentum when swimmers emerge from underwater with implications on the subsequent swimming kinematics, especially for male swimmers who employ underwater undulatory techniques.

  4. Looking for an accident: glider pilots' visual management and potentially dangerous final turns.

    Science.gov (United States)

    Jarvis, Steve; Harris, Don

    2007-06-01

    Accidents caused by spinning from low turns continue to kill glider pilots despite the introduction of specific exercises aimed at increasing pilot awareness and recognition of this issue. In-cockpit video cameras were used to analyze flying accuracy and log the areas of visual interest of 36 qualified glider pilots performing final turns in a training glider. Pilots were found to divide their attention between four areas of interest: the view directly ahead; the landing area (right); the airspeed indicator; and an area between the direct ahead view and the landing area. The mean fixation rate was 85 shifts per minute. Significant correlations were found between over-use of rudder and a lack of attention to the view ahead, as well as between the overall fixation rate and poorer coordination in the turn. The results provide some evidence that a relationship exists between pilots' visual management and making turns in a potentially dangerous manner. Pilots who monitor the view ahead for reasonable periods during the final turn while not allowing their scan to become over-busy are those who are most likely to prevent a potential spin.

  5. Timing in turn-taking and its implications for processing models of language

    Science.gov (United States)

    Levinson, Stephen C.; Torreira, Francisco

    2015-01-01

    The core niche for language use is in verbal interaction, involving the rapid exchange of turns at talking. This paper reviews the extensive literature about this system, adding new statistical analyses of behavioral data where they have been missing, demonstrating that turn-taking has the systematic properties originally noted by Sacks et al. (1974; hereafter SSJ). This system poses some significant puzzles for current theories of language processing: the gaps between turns are short (of the order of 200 ms), but the latencies involved in language production are much longer (over 600 ms). This seems to imply that participants in conversation must predict (or ‘project’ as SSJ have it) the end of the current speaker’s turn in order to prepare their response in advance. This in turn implies some overlap between production and comprehension despite their use of common processing resources. Collecting together what is known behaviorally and experimentally about the system, the space for systematic explanations of language processing for conversation can be significantly narrowed, and we sketch some first model of the mental processes involved for the participant preparing to speak next. PMID:26124727

  6. Taking turns across channels: Conversation-analytic tools in animal communication.

    Science.gov (United States)

    Fröhlich, Marlen

    2017-05-10

    In the quest to bridge the gulf between the fields of linguistics and animal communication, interest has recently been drawn to turn-taking behavior in social interaction. Vocal turn-taking is the core form of language usage in humans, and has been examined in numerous species of birds and primates. Recent studies on great apes have shown that they engage in a bodily form, gestural turn-taking, to achieve mutual communicative goals. However, most studies on turn-taking neglected the fact that signals are prevalently perceived and produced in a multimodal format. Here, I propose that research on animal communication may benefit a more holistic and dynamic approach: studying turn-taking using a multimodal, conservation-analytic framework. I will discuss recent comparative research that implemented this approach via a specific set of parameters. In sum, I argue that a conversation-analytic framework might help substantially to pinpoint the ways in which crucial components of language are embodied in the 'human interaction engine'. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Surface quality and topographic inspection of variable compliance part after precise turning

    Science.gov (United States)

    Nieslony, P.; Krolczyk, G. M.; Wojciechowski, S.; Chudy, R.; Zak, K.; Maruda, R. W.

    2018-03-01

    The paper presents the problem of precise turning of the mould parts with variable compliance and demonstrates a topographic inspection of the machined surface quality. The study was conducted for the cutting tools made of cemented carbide with coatings, in a range of variable cutting parameters. The long shaft with special axial hole, made of hardened 55NiCrMoV6 steel was selected as a workpiece. The carried out study included the stiffness measurement of the machining system, as well as the investigation of cutting force components. In this context, the surface topography parameters were evaluated using the stylus profile meter and analysed. The research revealed that the surface topography, alongside the 3D functional parameters, and PSD influences the performance of the machined surface. The lowest surface roughness parameters values, equalled to Sa = 1 μm and Sz = 4.3 μm have been obtained during turning with cutting speed vc = 90 m/min. The stable turning of variable compliance part affects the surface texture formation with a unidirectional perpendicular, anisotropic structure. Nevertheless, in case of unstable turning, the characteristic chatter marks are observed, and process dynamics has greater contribution in formation of surface finish than turning kinematics and elastic plastic deformation of workpiece.

  8. Travel Time Model for Right-Turning Vehicles of Secondary Street at Unsignalized Intersections

    Directory of Open Access Journals (Sweden)

    Feng Yu-Qin

    2013-01-01

    Full Text Available The travel time of right-turning vehicles on secondary street at unsignalized intersection is discussed in this paper. Under the assumption that the major-street through vehicles’ headway follows Erlang distribution and secondary-street right-turning vehicles’ headway follows Poisson distribution. The right-turning vehicles travel time model is established on the basis of gap theory and M/G/1 queue theory. Comparison is done with the common model based on the assumption that the major-street vehicles’ headway follows Poisson distribution. An intersection is selected to verify each model. The results show that the model established in this paper has stronger applicability, and its most relative error is less than 15%. In addition, the sensitivity analysis has been done. The results show that right-turning flow rate and major-street flow rate have a significant impact on the travel time. Hence, the methodology for travel time of right-turning vehicles at unsignalized intersection proposed in this paper is effective and applicable.

  9. SEARCHING FOR CRITERIA IN EVALUATING THE MONOFIN SWIMMING TURN FROM THE PERSPECTIVE OF COACHING AND IMPROVING TECHNIQUE

    Directory of Open Access Journals (Sweden)

    Marek Rejman

    2008-03-01

    Full Text Available This study aims to analysise the selected kinematic parameters of the monofin swimming turn. The high complexity of performing turns is hindered by the large surface of the monofin, which disturbs control and sense of the body in water. A lack of objective data available on monofin swimming turns has resulted in field research connected with the specification of parameters needed for the evaluation of the technique. Therefore, turns observed in elite swimmers contain underlying conclusions for objective criteria, ensuring the highest level of coaching and the improving of turns in young swimmers. Six, high level, male swimmers participated in the study. The subject of the analysis was the fastest turn, from one out of three trial turns made after swimming a distance of 25 m. Images of the turns were collected from two cameras located under water in accordance with the procedures of the previous analyses of freestyle turns. The images were digitized and analysed by the SIMI®- Movement Analysis System. The interdependency of the total turn time and the remaining recorded parameters, constituted the basis for analysis of the kinematic parameters of five turn phases. The interdependency was measured using r- Pearson's correlation coefficients. The novel character of the subject covered in this study, forced interpretation of the results on the basis of turn analyses in freestyle swimming. The results allow for the creation of a diagram outlinig area of search for an effective and efficient monofin swimming turn mechanism. The activities performed from the moment of wall contact until the commencement of stroking seem to be crucial for turn improvement. A strong belief has resulted that, the correct monofin swimming turn, is more than just a simple consequence of the fastest performance of all its components. The most important criteria in evaluating the quality of the monofin swimming turn are: striving for the optimal extension of wall contact

  10. The spatiotemporal constraint on the swimmer’s decision-making of turning

    Directory of Open Access Journals (Sweden)

    Thiago A. Costa de Oliveira

    2014-09-01

    Full Text Available This study investigated the swimmer’s decision-making process for turning, based on spatiotemporal informational variables. The men and women 50-metre front crawl and backstroke events were selected and analyzed using TACTO software. Participants included 120 adults of both genders aged between 20 and 70 years. The distance to the pool wall at which the swimmers initiated the turn was analyzed with regards to velocity and variability of previous displacement. These factors were split into four groups adopting, quartiles as the cut-off points. Results showed that for all conditions, the swimmers who showed a higher velocity and a lower variability of displacement decided to initiate the turn at a greater distance to the pool wall. Furthermore, the greater distance seemed to be associated with a more successful performance. These results suggest that swimmers should be attuned to spatiotemporal and spatial information in order to maximize their performance.

  11. Characterization of vibratory turning in cutting zone using a pneumatic quick-stop device

    Directory of Open Access Journals (Sweden)

    Saeid Amini

    2017-04-01

    Full Text Available Shear angle and sticking length are two crucial parameters in mechanics of metal cutting. These two parameters directly influence machinability factors such as cutting forces. Thus, shear angle and sticking length were investigated in vibratory turning process by using a pneumatic quick-stop device which was designed and fabricated, in this study. After preparation of ultrasonic assisted turning set-up, experimental tests have been carried out on two types of steel: AISI-1060 and AISI 304. Accordingly, the process of chip formation in each particular cutting test was quickly stopped when deformed chip was still in contact with workpiece. As a result, it was revealed that added linear vibration leads the turning operation to be improved by increase of shear angle and decrease of sticking length. Moreover, the effect of ultrasonic vibration on cutting force and chip micro-hardness is evaluated.

  12. Language, Space, Power: Reflections on Linguistic and Spatial Turns in Urban Research

    DEFF Research Database (Denmark)

    Vuolteenaho, Jani; Ameel, Lieven; Newby, Andrew

    2012-01-01

    first illustrate approaches characteristic of structuralism-inspired urban semiotics and postructuralism-affected discussions of the postmodern urban condition. In these research fronts, that were extremely fashionable in the late twentieth century, language was adopted as a pivotal metaphorical model......Seeking to locate the case studies of Language, Space and Power: Urban Entanglements in the context of recent academic history, this introductory article explores the manifestations and legacies of the so-called linguistic and spatial turns in urban research. With regard to the linguistic turn, we...... to conceptualise the power-embeddedness of urban spaces, processes and identities. More recently, however, the ramifications of the linguistic turn across urban research have proliferated as a result of approaches in which specific place-bound language practices and language-based representations about cities have...

  13. Investigation of variable spindle speed in slow tool servo-based turning of noncircular optical components

    Science.gov (United States)

    Huang, Weihai; Yu, Deping; Chen, Dongsheng; Zhang, Min; Liu, Jinguang; Yao, Jin

    2016-10-01

    Ultra-precision noncircular optical components, e.g. hyperbolic quadrupole in mass spectrometer, can be machined by diamond turning assisted by slow tool servo (STS). However, the bandwidth of STS is usually small, which limits the STS's capability in following the required tool path, leading to a large form error. To reduce the form error, this paper proposes an approach to apply variable spindle speed (VSS) to STS-based turning. Design of the VSS trajectory based on the noncircular profile of the optical component was investigated in detail. To validate the proposed approach, simulation on the application of VSS in the STS-based turning process was established and applied to the machining of typical noncircular optical components. Simulation results show that the proposed approach is effective in reducing the requirement on the bandwidth of the STS, resulting in higher form accuracy of the machined noncircular optical components.

  14. Optimization of machining parameters of turning operations based on multi performance criteria

    Directory of Open Access Journals (Sweden)

    N.K.Mandal

    2013-01-01

    Full Text Available The selection of optimum machining parameters plays a significant role to ensure quality of product, to reduce the manufacturing cost and to increase productivity in computer controlled manufacturing process. For many years, multi-objective optimization of turning based on inherent complexity of process is a competitive engineering issue. This study investigates multi-response optimization of turning process for an optimal parametric combination to yield the minimum power consumption, surface roughness and frequency of tool vibration using a combination of a Grey relational analysis (GRA. Confirmation test is conducted for the optimal machining parameters to validate the test result. Various turning parameters, such as spindle speed, feed and depth of cut are considered. Experiments are designed and conducted based on full factorial design of experiment.

  15. Vital New Matters: The Speculative Turn in the Study of Religion and Gender

    Directory of Open Access Journals (Sweden)

    Paul Reid-Bowen

    2011-08-01

    Full Text Available This article provides an introduction to a new trend in continental philosophy, the turn toward metaphysics, realism and speculative philosophy.  This stands in sharp contrast with the anitrealist and correlationist traditions that have held sway since Kant’s Copernican Revolution in 1781.  It is claimed that the study of religion and gender has been shaped by the antirealist legacy of Kant, but there are good reasons for taking account of the new ‘speculative turn’.  Two examples from the leading exponent of this turn, speculative realism, are introduced, and some provisional notes toward applying these to the gender-critical turn in the study of religion are considered.  Research notes on the current state of the Goddess movement serve as a test case for the introduction of an object-oriented ontology into religious and gender studies.

  16. Physical Modeling of Contact Processes on the Cutting Tools Surfaces of STM When Turning

    Science.gov (United States)

    Belozerov, V. A.; Uteshev, M. H.

    2016-08-01

    This article describes how to create an optimization model of the process of fine turning of superalloys and steel tools from STM on CNC machines, flexible manufacturing units (GPM), machining centers. Creation of the optimization model allows you to link (unite) contact processes simultaneously on the front and back surfaces of the tool from STM to manage contact processes and the dynamic strength of the cutting tool at the top of the STM. Established optimization model of management of the dynamic strength of the incisors of the STM in the process of fine turning is based on a previously developed thermomechanical (physical, heat) model, which allows the system thermomechanical approach to choosing brands STM (domestic and foreign) for cutting tools from STM designed for fine turning of heat resistant alloys and steels.

  17. Futbola turnīru vadības sistēma

    OpenAIRE

    Maksimčuks, Vladislavs

    2012-01-01

    Kvalifikācijas darbs apraksta izstrādātu „Futbola turnīru vadības sistēmu”, kas ir neliela resursu vadības sistēma. Tā nodrošina lietotājam centralizētu svarīgāko resursu uzskaiti, kas nepieciešami organizējot ikvienu futbola turnīru. Programmatūras pamatā ir klasifikatori, kurus ir iespējams apskatīt, pievienot jaunus ierakstus, labot vai dzēst esošos, kā arī katram no tiem ir dažādas specifiskās funkcijas. Atslēgvārdi: turnīru organizēšana, resursu vadības sistēma, RVS, C# .NET, MS SQL....

  18. The Need of the Revision of Passenger Ships’ Stability Criterion on Account of Turning

    Directory of Open Access Journals (Sweden)

    Zbigniew Szozda

    2014-09-01

    Full Text Available The angle of heel on account of turning is one of the mandatory stability criteria for passenger ships. Formula used for calculations of this criterion contained in the International Code on Intact Stability [13] is criticized at present. Agendas of the Sub-committee on Ship Design and Construction (SDC for the first (2014 and the second (2015 sessions contain the item on revision of this criterion and corresponding regulation. The paper presents some shortcomings of the criterion. Turning tests of a freely maneuvering model of a passenger ship have been executed aiming at gathering data for the future discussion and its facilitation. The paper presents results of the tests together with preliminary conclusions that confirm the need of the revision of the regulation and put forward concerns on application of such values as initial metacentric height (GMo and righting lever curve (GZ(? calculated for a ship laying still for calculation of a ship’s heel caused by turn.

  19. Exploring Factors Impacting Paths of Left-Turning Vehicles from Minor Road Approach at Unsignalized Intersections

    Directory of Open Access Journals (Sweden)

    Guoqiang Zhang

    2016-01-01

    Full Text Available At unsignalized intersections, left-turning vehicles from minor road approach are more likely to be involved in traffic conflicts and traffic crashes and are one of the most leading factors impacting traffic efficiency and capacity. The authors of the paper observed that some drivers behaved illegally and dangerously while performing left turns from minor road approach, resulting in abnormal trajectories at unsignalized intersections. By applying binary logistic analysis, a probability prediction model was developed to explore various factors affecting probability of normal path taken by drivers while turning left from minor road approach. Based upon the model, measures such as lowering running speeds of vehicles on major road or minor road and adding more lanes on minor road can be used to encourage more drivers to take normal vehicle paths, which is helpful for the improvement of traffic safety, efficiency, and capacity. Results of the paper can be used for the guidance of design and management of unsignalized intersections.

  20. Spatiotemporal and Kinematic Parameters Relating to Oriented Gait and Turn Performance in Patients with Chronic Stroke.

    Directory of Open Access Journals (Sweden)

    Céline Bonnyaud

    Full Text Available The timed up and go test (TUG is a functional test which is increasingly used to evaluate patients with stroke. The outcome measured is usually global TUG performance-time. Assessment of spatiotemporal and kinematic parameters during the Oriented gait and Turn sub-tasks of the TUG would provide a better understanding of the mechanisms underlying patients' performance and therefore may help to guide rehabilitation. The aim of this study was thus to determine the spatiotemporal and kinematic parameters which were most related to the walking and turning sub-tasks of TUG performance in stroke patients.29 stroke patients carried out the TUG test which was recorded using an optoelectronic system in two conditions: spontaneous and standardized condition (standardized foot position and instructed to turn towards the paretic side. They also underwent a clinical assessment. Stepwise regression was used to determine the parameters most related to Oriented gait and Turn sub-tasks. Relationships between explanatory parameters of Oriented gait and Turn performance and clinical scales were evaluated using Spearman correlations.Step length and cadence explained 82% to 95% of the variance for the walking sub-tasks in both conditions. Percentage single support phase and contralateral swing phase (depending on the condition respectively explained 27% and 56% of the variance during the turning sub-task in the spontaneous and standardized conditions.Step length, cadence, percentage of paretic single support phase and non-paretic swing phase, as well as dynamic stability were the main parameters related to TUG performance and they should be targeted in rehabilitation.