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Sample records for bundle dfsc peptides

  1. Hexagonally Ordered Arrays of α-Helical Bundles Formed from Peptide-Dendron Hybrids

    Energy Technology Data Exchange (ETDEWEB)

    Barkley, Deborah A. [Department; Rokhlenko, Yekaterina [Department; Marine, Jeannette E. [Department; David, Rachelle [Department; Sahoo, Dipankar [Department; Watson, Matthew D. [Department; Koga, Tadanori [Department; Department; Osuji, Chinedum O. [Department; Rudick, Jonathan G. [Department

    2017-10-24

    Combining monodisperse building blocks that have distinct folding properties serves as a modular strategy for controlling structural complexity in hierarchically organized materials. We combine an α-helical bundle-forming peptide with self-assembling dendrons to better control the arrangement of functional groups within cylindrical nanostructures. Site-specific grafting of dendrons to amino acid residues on the exterior of the α-helical bundle yields monodisperse macromolecules with programmable folding and self-assembly properties. The resulting hybrid biomaterials form thermotropic columnar hexagonal mesophases in which the peptides adopt an α-helical conformation. Bundling of the α-helical peptides accompanies self-assembly of the peptide-dendron hybrids into cylindrical nanostructures. The bundle stoichiometry in the mesophase agrees well with the size found in solution for α-helical bundles of peptides with a similar amino acid sequence.

  2. Structural Studies of Amphiphilic 4-Helix Bundle Peptides Incorporating Designed Extended Chromophores for Nonlinear Optical Biomolecular Materials

    Energy Technology Data Exchange (ETDEWEB)

    Strzalka,J.; Xu, T.; Tronin, A.; Wu, S.; Miloradovic, I.; Kuzmenko, I.; Gog, T.; Therien, M.; Blasie, K.

    2006-01-01

    Extended conjugated chromophores containing (porphinato)zinc components that exhibit large optical polarizabilities and hyperpolarizabiliites are incorporated into amphiphilic 4-helix bundle peptides via specific axial histidyl ligation of the metal. The bundle's designed amphiphilicity enables vectorial orientation of the chromophore/peptide complex in macroscopic monolayer ensembles. The 4-helix bundle structure is maintained upon incorporation of two different chromophores at stoichiometries of 1-2 per bundle. The axial ligation site appears to effectively control the position of the chromophore along the length of the bundle.

  3. Understanding Peptide Oligomeric State in Langmuir Monolayers of Amphiphilic 3-Helix Bundle-Forming Peptide-PEG Conjugates.

    Science.gov (United States)

    Lund, Reidar; Ang, JooChuan; Shu, Jessica Y; Xu, Ting

    2016-12-12

    Coiled-coil peptide-polymer conjugates are an emerging class of biomaterials. Fundamental understanding of the coiled-coil oligomeric state and assembly process of these hybrid building blocks is necessary to exert control over their assembly into well-defined structures. Here, we studied the effect of peptide structure and PEGylation on the self-assembly process and oligomeric state of a Langmuir monolayer of amphiphilic coiled-coil peptide-polymer conjugates using X-ray reflectivity (XR) and grazing-incidence X-ray diffraction (GIXD). Our results show that the oligomeric state of PEGylated amphiphiles based on 3-helix bundle-forming peptide is surface pressure dependent, a mixture of dimers and trimers was formed at intermediate surface pressure but transitions into trimers completely upon increasing surface pressure. Moreover, the interhelical distance within the coiled-coil bundle of 3-helix peptide-PEG conjugate amphiphiles was not perturbed under high surface pressure. Present studies provide valuable insights into the self-assembly process of hybrid peptide-polymer conjugates and guidance to develop biomaterials with controlled multivalency of ligand presentation.

  4. Amphiphilic Four-Helix Bundle Peptides Designed for Light-Induced Electron Transfer Across a Soft Interface

    Energy Technology Data Exchange (ETDEWEB)

    Ye,S.; Discher, B.; Strzalka, J.; Xu, T.; Wu, S.; Noy, D.; Kuzmenko, I.; Gog, T.; Blasie, K.; et al.

    2005-01-01

    A family of four-helix bundle peptides were designed to be amphiphilic, possessing distinct hydrophilic and hydrophobic domains along the length of the bundle's exterior. This facilitates their vectorial insertion across a soft interface between polar and nonpolar media. Their design also now provides for selective incorporation of electron donor and acceptor cofactors within each domain. This allows translation of the designed intramolecular electron transfer along the bundle axis into a macroscopic charge separation across the interface.

  5. Early steps of HIV-1 fusion define the sensitivity to inhibitory peptides that block 6-helix bundle formation.

    Directory of Open Access Journals (Sweden)

    Kosuke Miyauchi

    2009-09-01

    Full Text Available The HIV envelope (Env glycoprotein mediates membrane fusion through sequential interactions with CD4 and coreceptors, followed by the refolding of the transmembrane gp41 subunit into the stable 6-helix bundle (6HB conformation. Synthetic peptides derived from the gp41 C-terminal heptad repeat domain (C-peptides potently inhibit fusion by binding to the gp41 pre-bundle intermediates and blocking their conversion into the 6HB. Our recent work revealed that HIV-1 enters cells by fusing with endosomes, but not with the plasma membrane. These studies also showed that, for the large part, gp41 pre-bundles progress toward 6HBs in endosomal compartments and are thus protected from external fusion inhibitors. Here, we examined the consequences of endocytic entry on the gp41 pre-bundle exposure and on the virus' sensitivity to C-peptides. The rates of CD4 and coreceptor binding, as well as the rate of productive receptor-mediated endocytosis, were measured by adding specific inhibitors of these steps at varied times of virus-cell incubation. Following the CD4 binding, CCR5-tropic viruses recruited a requisite number of coreceptors much faster than CXCR4-tropic viruses. The rate of subsequent uptake of ternary Env-CD4-coreceptor complexes did not correlate with the kinetics of coreceptor engagement. These measurements combined with kinetic analyses enabled the determination of the lifetime of pre-bundle intermediates on the cell surface. Overall, these lifetimes correlated with the inhibitory potency of C-peptides. On the other hand, the basal sensitivity to peptides varied considerably among diverse HIV-1 isolates and ranked similarly with their susceptibility to inactivation by soluble CD4. We conclude that both the longevity of gp41 intermediates and the extent of irreversible conformational changes in Env upon CD4 binding determine the antiviral potency of C-peptides.

  6. Arginine–glycine–aspartic acid (RGD)-containing peptides inhibit the force production of mouse papillary muscle bundles via α5β1 integrin

    Science.gov (United States)

    Sarin, Vandana; Gaffin, Robert D; Meininger, Gerald A; Muthuchamy, Mariappan

    2005-01-01

    Integrins are considered to be an important mechanosensor in cardiac myocytes. To test whether integrins can influence cardiac contractile function, the force–frequency relationships of mouse papillary muscle bundles were measured in the presence or absence of a synthetic integrin-binding peptide, GRGDNP (gly–arg–gly–asp–asn–pro). Results demonstrate that in the presence of an arginine–glycine–aspartic acid (RGD)-containing synthetic peptide, contractile force was depressed significantly by, 28% at 4 Hz, 37.7% at 5 Hz and 20% at 10 Hz (n = 6, P < 0.01). Treatment of myofibres with either protease-generated fragments of denatured collagen (Type I) or denatured collagen that contain the RGD motif, also reduced force production significantly. An integrin-activating antibody for β1 integrin inhibited the force similar to synthetic RGD peptide. Function-blocking integrin antibodies for α5 and β1 integrins reversed the effect of the RGD-containing peptide, and α5 integrin also reversed the effect of proteolytic fragments of denatured collagen on contractile force, whereas experiments with function-blocking antibody for β3 integrin did not reverse the effect of RGD peptide. Force–[Ca2+]i measurements showed that the depressed rate of force generation observed in the presence of the RGD-containing peptide was associated with reduced [Ca2+]i. Data analyses further demonstrated that force per unit of Ca2+ was reduced, suggesting that the myofilament activation process was altered. In addition, inhibition of PKC enzyme using the selective, cell-permeable inhibitor Ro-32-0432, reversed the activity of RGD peptide on papillary muscle bundles. In conclusion, these data indicate that RGD peptide, acting via α5β1 integrin, depresses the force production from papillary muscle bundles, partly associated with changes in [Ca2+]i and the myofilament activation processes, that is modulated by PKCε. PMID:15718258

  7. Acentric 2-D ensembles of D-br-A electron-transfer chromophores via vectorial orientation within amphiphilic n-helix bundle peptides for photovoltaic device applications.

    Science.gov (United States)

    Koo, Jaseung; Park, Jaehong; Tronin, Andrey; Zhang, Ruili; Krishnan, Venkata; Strzalka, Joseph; Kuzmenko, Ivan; Fry, H Christopher; Therien, Michael J; Blasie, J Kent

    2012-02-14

    We show that simply designed amphiphilic 4-helix bundle peptides can be utilized to vectorially orient a linearly extended donor-bridge-acceptor (D-br-A) electron transfer (ET) chromophore within its core. The bundle's interior is shown to provide a unique solvation environment for the D-br-A assembly not accessible in conventional solvents and thereby control the magnitudes of both light-induced ET and thermal charge recombination rate constants. The amphiphilicity of the bundle's exterior was employed to vectorially orient the peptide-chromophore complex at a liquid-gas interface, and its ends were tailored for subsequent covalent attachment to an inorganic surface, via a "directed assembly" approach. Structural data, combined with evaluation of the excited state dynamics exhibited by these peptide-chromophore complexes, demonstrate that densely packed, acentrically ordered 2-D monolayer ensembles of such complexes at high in-plane chromophore densities approaching 1/200 Å(2) offer unique potential as active layers in binary heterojunction photovoltaic devices.

  8. Single Actin Bundle Rheology.

    Science.gov (United States)

    Strehle, Dan; Mollenkopf, Paul; Glaser, Martin; Golde, Tom; Schuldt, Carsten; Käs, Josef A; Schnauß, Jörg

    2017-10-24

    Bundled actin structures play an essential role in the mechanical response of the actin cytoskeleton in eukaryotic cells. Although responsible for crucial cellular processes, they are rarely investigated in comparison to single filaments and isotropic networks. Presenting a highly anisotropic structure, the determination of the mechanical properties of individual bundles was previously achieved through passive approaches observing bending deformations induced by thermal fluctuations. We present a new method to determine the bending stiffness of individual bundles, by measuring the decay of an actively induced oscillation. This approach allows us to systematically test anisotropic, bundled structures. Our experiments revealed that thin, depletion force-induced bundles behave as semiflexible polymers and obey the theoretical predictions determined by the wormlike chain model. Thickening an individual bundle by merging it with other bundles enabled us to study effects that are solely based on the number of involved filaments. These thicker bundles showed a frequency-dependent bending stiffness, a behavior that is inconsistent with the predictions of the wormlike chain model. We attribute this effect to internal processes and give a possible explanation with regard to the wormlike bundle theory.

  9. Single Actin Bundle Rheology

    Directory of Open Access Journals (Sweden)

    Dan Strehle

    2017-10-01

    Full Text Available Bundled actin structures play an essential role in the mechanical response of the actin cytoskeleton in eukaryotic cells. Although responsible for crucial cellular processes, they are rarely investigated in comparison to single filaments and isotropic networks. Presenting a highly anisotropic structure, the determination of the mechanical properties of individual bundles was previously achieved through passive approaches observing bending deformations induced by thermal fluctuations. We present a new method to determine the bending stiffness of individual bundles, by measuring the decay of an actively induced oscillation. This approach allows us to systematically test anisotropic, bundled structures. Our experiments revealed that thin, depletion force-induced bundles behave as semiflexible polymers and obey the theoretical predictions determined by the wormlike chain model. Thickening an individual bundle by merging it with other bundles enabled us to study effects that are solely based on the number of involved filaments. These thicker bundles showed a frequency-dependent bending stiffness, a behavior that is inconsistent with the predictions of the wormlike chain model. We attribute this effect to internal processes and give a possible explanation with regard to the wormlike bundle theory.

  10. Cytoskeletal bundle mechanics

    NARCIS (Netherlands)

    Bathe, Mark; Heussinger, Claus; Claessens, Mireille Maria Anna Elisabeth; Bausch, Andreas R.; Frey, Erwin

    2008-01-01

    The mechanical properties of cytoskeletal actin bundles play an essential role in numerous physiological processes, including hearing, fertilization, cell migration, and growth. Cells employ a multitude of actin-binding proteins to actively regulate bundle dimensions and cross-linking properties to

  11. The ABCDEF Implementation Bundle

    Directory of Open Access Journals (Sweden)

    Annachiara Marra

    2016-08-01

    Full Text Available Long-term morbidity, long-term cognitive impairment and hospitalization-associated disability are common occurrence in the survivors of critical illness, with significant consequences for patients and for the caregivers. The ABCDEF bundle represents an evidence-based guide for clinicians to approach the organizational changes needed for optimizing ICU patient recovery and outcomes. The ABCDEF bundle includes: Assess, Prevent, and Manage Pain, Both Spontaneous Awakening Trials (SAT and Spontaneous Breathing Trials (SBT, Choice of analgesia and sedation, Delirium: Assess, Prevent, and Manage, Early mobility and Exercise, and Family engagement. The purpose of this review is to describe the core features of the ABCDEF bundle.

  12. Bundle Branch Block

    Science.gov (United States)

    ... 2015. Bundle branch block Symptoms & causes Diagnosis & treatment Advertisement Mayo Clinic does not endorse companies or products. ... a Job Site Map About This Site Twitter Facebook Google YouTube Pinterest Mayo Clinic is a not- ...

  13. Thermodynamics of fiber bundles

    OpenAIRE

    Pride, Steven R.; Toussaint, Renaud

    2002-01-01

    A recent theory that determines the properties of disordered solids as the solid accumulates damage is applied to the special case of fiber bundles with global load sharing and is shown to be exact in this case. The theory postulates that the probability of observing a given emergent damage state is obtained by maximizing the emergent entropy as defined by Shannon subject to energetic constraints. This theory yields the known exact results for the fiber-bundle model with global load sharing a...

  14. Right bundle branch block

    DEFF Research Database (Denmark)

    Bussink, Barbara E; Holst, Anders Gaarsdal; Jespersen, Lasse

    2013-01-01

    AimsTo determine the prevalence, predictors of newly acquired, and the prognostic value of right bundle branch block (RBBB) and incomplete RBBB (IRBBB) on a resting 12-lead electrocardiogram in men and women from the general population.Methods and resultsWe followed 18 441 participants included.......5%/2.3% in women, P Right bundle branch block was associated with significantly...... increased all-cause and cardiovascular mortality in both genders with age-adjusted hazard ratios (HR) of 1.31 [95% confidence interval (CI), 1.11-1.54] and 1.87 (95% CI, 1.48-2.36) in the gender pooled analysis with little attenuation after multiple adjustment. Right bundle branch block was associated...

  15. Bundles of Banach algebras

    Directory of Open Access Journals (Sweden)

    J. W. Kitchen

    1994-01-01

    Full Text Available We study bundles of Banach algebras π:A→X, where each fiber Ax=π−1({x} is a Banach algebra and X is a compact Hausdorff space. In the case where all fibers are commutative, we investigate how the Gelfand representation of the section space algebra Γ(π relates to the Gelfand representation of the fibers. In the general case, we investigate how adjoining an identity to the bundle π:A→X relates to the standard adjunction of identities to the fibers.

  16. Buying bundles: the effects of bundle attributes on the value of bundling

    OpenAIRE

    Linthorst, M.M.; Telgen, Jan; Schotanus, Fredo

    2008-01-01

    We consider the situation in which a buyer has to find the optimal degree of bundling for buying goods and services. From a review of the literature we develop attributes associated with bundling. Each of these attributes has an effect on the value of a bundle. Combined, the attributes determine the value of a bundle. We describe how the various attributes of a bundle contribute to the value of a bundle given the context of the buying situation. Based on interviews, a further analysis of bund...

  17. Buying bundles: the effects of bundling attributes on the value of bundling

    OpenAIRE

    Linthorst, M.M.; Telgen, Jan; Schotanus, Fredo

    2008-01-01

    We consider the situation in which a buyer has to find the optimal degree of bundling for buying goods and services. From a review of the literature we develop attributes associated with bundling. Each of these attributes has an effect on the value of a bundle. Combined, the attributes determine the value of a bundle. We describe how the various attributes of a bundle contribute to the value of a bundle given the context of the buying situation. Based on interviews, a further analysis of bund...

  18. ALUMINUM BOX BUNDLING PRESS

    Directory of Open Access Journals (Sweden)

    Iosif DUMITRESCU

    2015-05-01

    Full Text Available In municipal solid waste, aluminum is the main nonferrous metal, approximately 80- 85% of the total nonferrous metals. The income per ton gained from aluminum recuperation is 20 times higher than from glass, steel boxes or paper recuperation. The object of this paper is the design of a 300 kN press for aluminum box bundling.

  19. Dynamics of flagellar bundling

    Science.gov (United States)

    Janssen, Pieter; Graham, Michael

    2010-11-01

    Flagella are long thin appendages of microscopic organisms used for propulsion in low-Reynolds environments. For E. coli the flagella are driven by a molecular motor, which rotates the flagella in a counter-clockwise motion (CCM). When in a forward swimming motion, all flagella bundle up. If a motor reverses rotation direction, the flagella unbundle and the cell makes a tumbling motion. When all motors turn in the same CC direction again, the flagella bundle up, and forward swimming continues. To investigate the bundling, we consider two flexible helices next to each other, as well as several flagella attached to a spherical body. Each helix is modeled as several prolate spheroids connected at the tips by springs. For hydrodynamic interactions, we consider the flagella to made up of point forces, while the finite size of the body is incorporated via Fax'en's laws. We show that synchronization occurs quickly relative to the bundling process. For flagella next to each other, the initial deflection is generated by rotlet interactions generated by the rotating helices. At longer times, simulations show the flagella only wrap once around each other, but only for flagella that are closer than about 4 helix radii. Finally, we show a run-and-tumble motion of the body with attached flagella.

  20. Designing cooperatively folded abiotic uni- and multimolecular helix bundles

    Science.gov (United States)

    de, Soumen; Chi, Bo; Granier, Thierry; Qi, Ting; Maurizot, Victor; Huc, Ivan

    2018-01-01

    Abiotic foldamers, that is foldamers that have backbones chemically remote from peptidic and nucleotidic skeletons, may give access to shapes and functions different to those of peptides and nucleotides. However, design methodologies towards abiotic tertiary and quaternary structures are yet to be developed. Here we report rationally designed interactional patterns to guide the folding and assembly of abiotic helix bundles. Computational design facilitated the introduction of hydrogen-bonding functionalities at defined locations on the aromatic amide backbones that promote cooperative folding into helix-turn-helix motifs in organic solvents. The hydrogen-bond-directed aggregation of helices not linked by a turn unit produced several thermodynamically and kinetically stable homochiral dimeric and trimeric bundles with structures that are distinct from the designed helix-turn-helix. Relative helix orientation within the bundles may be changed from parallel to tilted on subtle solvent variations. Altogether, these results prefigure the richness and uniqueness of abiotic tertiary structure behaviour.

  1. Bundle pricing with comparable items

    NARCIS (Netherlands)

    Grigoriev, Alexander; van Loon, Joyce; Sviridenko, Maxim; Uetz, Marc Jochen; Vredeveld, Tjark; Arge, L.; Hoffmann, M.; Welzl, E.

    2007-01-01

    We consider a revenue maximization problem where we are selling a set of items, each available in a certain quantity, to a set of bidders. Each bidder is interested in one or several bundles of items. We assume the bidders’ valuations for each of these bundles to be known. Whenever bundle prices are

  2. Bundling ecosystem services in Denmark

    DEFF Research Database (Denmark)

    Turner, Katrine Grace; Odgaard, Mette Vestergaard; Bøcher, Peder Klith

    2014-01-01

    to form synergies. We identified six distinct ecosystem service bundle types, indicating multiple interactions at a landscape level. The bundle types showed specialized areas of agricultural production, high provision of cultural services at the coasts, multifunctional mixed-use bundle types around urban...

  3. Buying bundles: the effects of bundling attributes on the value of bundling

    NARCIS (Netherlands)

    Linthorst, M.M.; Telgen, Jan; Schotanus, Fredo

    2008-01-01

    We consider the situation in which a buyer has to find the optimal degree of bundling for buying goods and services. From a review of the literature we develop attributes associated with bundling. Each of these attributes has an effect on the value of a bundle. Combined, the attributes determine the

  4. Buying bundles: the effects of bundle attributes on the value of bundling

    NARCIS (Netherlands)

    Linthorst, M.M.; Telgen, Jan; Schotanus, Fredo

    2008-01-01

    We consider the situation in which a buyer has to find the optimal degree of bundling for buying goods and services. From a review of the literature we develop attributes associated with bundling. Each of these attributes has an effect on the value of a bundle. Combined, the attributes determine the

  5. Helices and vector bundles

    CERN Document Server

    Rudakov, A N

    1990-01-01

    This volume is devoted to the use of helices as a method for studying exceptional vector bundles, an important and natural concept in algebraic geometry. The work arises out of a series of seminars organised in Moscow by A. N. Rudakov. The first article sets up the general machinery, and later ones explore its use in various contexts. As to be expected, the approach is concrete; the theory is considered for quadrics, ruled surfaces, K3 surfaces and P3(C).

  6. Bundling harvester; Nippukorjausharvesteri

    Energy Technology Data Exchange (ETDEWEB)

    Koponen, K. [Eko-Log Oy, Kuopio (Finland)

    1996-12-31

    The staring point of the project was to design and construct, by taking the silvicultural point of view into account, a harvesting and processing system especially for energy-wood, containing manually driven bundling harvester, automatizing of the harvester, and automatized loading. The equipment forms an ideal method for entrepreneur`s-line harvesting. The target is to apply the system also for owner`s-line harvesting. The profitability of the system promotes the utilization of the system in both cases. The objectives of the project were: to construct a test equipment and prototypes for all the project stages, to carry out terrain and strain tests in order to examine the usability and durability, as well as the capacity of the machine, to test the applicability of the Eko-Log system in simultaneous harvesting of energy and pulp woods, and to start the marketing and manufacturing of the products. The basic problems of the construction of the bundling harvester have been solved using terrain-tests. The prototype machine has been shown to be operable. Loading of the bundles to form sufficiently economically transportable loads has been studied, and simultaneously, the branch-biomass has been tried to be utilized without loosing the profitability of transportation. The results have been promising, and will promote the profitable utilization of wood-energy

  7. Bundled payments in orthopedic surgery.

    Science.gov (United States)

    Bushnell, Brandon D

    2015-02-01

    As a result of reading this article, physicians should be able to: 1. Describe the concept of bundled payments and the potential applications of bundled payments in orthopedic surgery. 2. For specific situations, outline a clinical episode of care, determine the participants in a bundling situation, and define care protocols and pathways. 3. Recognize the importance of resource utilization management, quality outcome measurement, and combined economic-clinical value in determining the value of bundled payment arrangements. 4. Identify the implications of bundled payments for practicing orthopedists, as well as the legal issues and potential future directions of this increasingly popular alternative payment method. Bundled payments, the idea of paying a single price for a bundle of goods and services, is a financial concept familiar to most American consumers because examples appear in many industries. The idea of bundled payments has recently gained significant momentum as a financial model with the potential to decrease the significant current costs of health care. Orthopedic surgery as a field of medicine is uniquely positioned for success in an environment of bundled payments. This article reviews the history, logistics, and implications of the bundled payment model relative to orthopedic surgery. Copyright 2015, SLACK Incorporated.

  8. Muon bundles from the Universe

    Directory of Open Access Journals (Sweden)

    Kankiewicz P.

    2018-01-01

    Full Text Available Recently the CERN ALICE experiment, in its dedicated cosmic ray run, observed muon bundles of very high multiplicities, thereby confirming similar findings from the LEP era at CERN (in the CosmoLEP project. Significant evidence for anisotropy of arrival directions of the observed high multiplicity muonic bundles is found. Estimated directionality suggests their possible extragalactic provenance. We argue that muonic bundles of highest multiplicity are produced by strangelets, hypothetical stable lumps of strange quark matter infiltrating our Universe.

  9. Lipid-peptide-polymer conjugates and nanoparticles thereof

    Science.gov (United States)

    Xu, Ting; Dong, He; Shu, Jessica

    2015-06-02

    The present invention provides a conjugate having a peptide with from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure. The conjugate also includes a first polymer covalently linked to the peptide, and a hydrophobic moiety covalently linked to the N-terminus of the peptide, wherein the hydrophobic moiety comprises a second polymer or a lipid moiety. The present invention also provides helix bundles form by self-assembling the conjugates, and particles formed by self-assembling the helix bundles. Methods of preparing the helix bundles and particles are also provided.

  10. Bundle Formation in Biomimetic Hydrogels

    NARCIS (Netherlands)

    Jaspers, Maarten; Pape, A C H; Voets, Ilja K; Rowan, Alan E; Portale, Giuseppe; Kouwer, Paul H J

    2016-01-01

    Bundling of single polymer chains is a crucial process in the formation of biopolymer network gels that make up the extracellular matrix and the cytoskeleton. This bundled architecture leads to gels with distinctive properties, including a large-pore-size gel formation at very low concentrations and

  11. Bundle Security Protocol for ION

    Science.gov (United States)

    Burleigh, Scott C.; Birrane, Edward J.; Krupiarz, Christopher

    2011-01-01

    This software implements bundle authentication, conforming to the Delay-Tolerant Networking (DTN) Internet Draft on Bundle Security Protocol (BSP), for the Interplanetary Overlay Network (ION) implementation of DTN. This is the only implementation of BSP that is integrated with ION.

  12. Fiber bundle phase conjugate mirror

    Science.gov (United States)

    Ward, Benjamin G.

    2012-05-01

    An improved method and apparatus for passively conjugating the phases of a distorted wavefronts resulting from optical phase mismatch between elements of a fiber laser array are disclosed. A method for passively conjugating a distorted wavefront comprises the steps of: multiplexing a plurality of probe fibers and a bundle pump fiber in a fiber bundle array; passing the multiplexed output from the fiber bundle array through a collimating lens and into one portion of a non-linear medium; passing the output from a pump collection fiber through a focusing lens and into another portion of the non-linear medium so that the output from the pump collection fiber mixes with the multiplexed output from the fiber bundle; adjusting one or more degrees of freedom of one or more of the fiber bundle array, the collimating lens, the focusing lens, the non-linear medium, or the pump collection fiber to produce a standing wave in the non-linear medium.

  13. Semiflexible Biopolymers in Bundled Arrangements

    Directory of Open Access Journals (Sweden)

    Jörg Schnauß

    2016-07-01

    Full Text Available Bundles and networks of semiflexible biopolymers are key elements in cells, lending them mechanical integrity while also enabling dynamic functions. Networks have been the subject of many studies, revealing a variety of fundamental characteristics often determined via bulk measurements. Although bundles are equally important in biological systems, they have garnered much less scientific attention since they have to be probed on the mesoscopic scale. Here, we review theoretical as well as experimental approaches, which mainly employ the naturally occurring biopolymer actin, to highlight the principles behind these structures on the single bundle level.

  14. MAVEN EUV Modelled Data Bundle

    Data.gov (United States)

    National Aeronautics and Space Administration — This bundle contains solar irradiance spectra in 1-nm bins from 0-190 nm. The spectra are generated based upon the Flare Irradiance Spectra Model - Mars (FISM-M)...

  15. Left bundle-branch block

    DEFF Research Database (Denmark)

    Risum, Niels; Strauss, David; Sogaard, Peter

    2013-01-01

    The relationship between myocardial electrical activation by electrocardiogram (ECG) and mechanical contraction by echocardiography in left bundle-branch block (LBBB) has never been clearly demonstrated. New strict criteria for LBBB based on a fundamental understanding of physiology have recently...

  16. MAVEN SWEA Calibrated Data Bundle

    Data.gov (United States)

    National Aeronautics and Space Administration — This bundle contains fully calibrated electron energy/angle (3D) distributions, pitch angle distributions, and omni-directional energy spectra. Tables of sensitivity...

  17. MAVEN LPW Derived Data Bundle

    Data.gov (United States)

    National Aeronautics and Space Administration — This bundle contains data which have been derived from other data products or determined by fits to other data. These are science quality data produced by the LPW...

  18. MAVEN LPW Calibrated Data Bundle

    Data.gov (United States)

    National Aeronautics and Space Administration — This bundle contains fully calibrated, science quality data produced by the LPW instrument. The data include spacecraft potential, electric field waveforms and wave...

  19. GPU Parallel Bundle Block Adjustment

    Directory of Open Access Journals (Sweden)

    ZHENG Maoteng

    2017-09-01

    Full Text Available To deal with massive data in photogrammetry, we introduce the GPU parallel computing technology. The preconditioned conjugate gradient and inexact Newton method are also applied to decrease the iteration times while solving the normal equation. A brand new workflow of bundle adjustment is developed to utilize GPU parallel computing technology. Our method can avoid the storage and inversion of the big normal matrix, and compute the normal matrix in real time. The proposed method can not only largely decrease the memory requirement of normal matrix, but also largely improve the efficiency of bundle adjustment. It also achieves the same accuracy as the conventional method. Preliminary experiment results show that the bundle adjustment of a dataset with about 4500 images and 9 million image points can be done in only 1.5 minutes while achieving sub-pixel accuracy.

  20. Twist-off purification of hair bundles.

    Science.gov (United States)

    Shin, Jung-Bum; Pagana, James; Gillespie, Peter G

    2009-01-01

    Purification of hair bundles from inner-ear organs allows biochemical analysis of bundle constituents, including proteins and lipids. We describe here the "twist-off" method of bundle isolation, where dissected inner-ear organs are embedded in agarose, then subjected to a mechanical disruption that shears off bundles and leaves them in agarose blocks. With care in the dissection and in clean-up of the isolated bundles, contamination from cell bodies can be kept to a minimum. Isolated bundles can be analyzed by a variety of techniques, including immunocytochemistry, SDS-PAGE, immunoblotting, and mass spectrometry.

  1. Principal bundles the classical case

    CERN Document Server

    Sontz, Stephen Bruce

    2015-01-01

    This introductory graduate level text provides a relatively quick path to a special topic in classical differential geometry: principal bundles.  While the topic of principal bundles in differential geometry has become classic, even standard, material in the modern graduate mathematics curriculum, the unique approach taken in this text presents the material in a way that is intuitive for both students of mathematics and of physics. The goal of this book is to present important, modern geometric ideas in a form readily accessible to students and researchers in both the physics and mathematics communities, providing each with an understanding and appreciation of the language and ideas of the other.

  2. ADE bundles over surfaces with ADE singularities

    OpenAIRE

    Chen, Yunxia; Leung, Naichung Conan

    2012-01-01

    Given a complex projective surface with an ADE singularity and p_{g}=0, we construct ADE bundles over it and its minimal resolution. Furthermore, we descibe their minuscule representation bundles in terms of configurations of (reducible) (-1)-curves.

  3. PDS4 Bundle Creation Governance Using BPMN

    Science.gov (United States)

    Radulescu, C.; Levoe, S. R.; Algermissen, S. S.; Rye, E. D.; Hardman, S. H.

    2015-06-01

    The AMMOS-PDS Pipeline Service (APPS) provides a Bundle Builder tool, which governs the process of creating, and ultimately generates, PDS4 bundles incrementally, as science products are being generated.

  4. Developing the bundled glass column

    NARCIS (Netherlands)

    Oikonomopoulou, F.; Bristogianni, T; Veer, F.A.; Nijsse, R.; da Sousa Cruz, Paulo J.

    In this paper a bundled glass column is presented as a promising solution for a completely transparent, almost dematerialized structural compressive element. The aim is to ob-tain a glass column that can safely carry loads, achieve a high visual result and be relatively eas-ily manufactured.

  5. Line bundles and flat connections

    Indian Academy of Sciences (India)

    /fulltext/pmsc/127/03/0547-0549. Keywords. Calabi–Yau threefold; torsion; cocompact lattice; unitary representation. Abstract. We prove that there are cocompact lattices Γ in S L ( 2 , C ) with the property that there are holomorphic line bundles ...

  6. Line bundles and flat connections

    Indian Academy of Sciences (India)

    Calabi–Yau threefold; torsion; cocompact lattice; unitary representation. 2000 Mathematics Subject Classification. 81T30, 14D21, 53C07. 1. Stable bundles and unitary flat connections. 1.1 Admitting flat connections. Let X be a compact connected complex manifold of complex dimension δ. Let ω be the. (1, 1)-form on X ...

  7. Chemical vapor infiltration in single fiber bundles

    Energy Technology Data Exchange (ETDEWEB)

    Devlin, D.J.; Barbero, R.S.; Currier, R.P.

    1990-01-01

    Chemical vapor infiltration (CVI) in single fiber bundles is studied under isothermal conditions. Understanding infiltration dynamics in single bundles is essential to process design and modeling efforts. Deposition of pyrolytic carbon in carbon-fiber bundles is chosen as the experimental system, with densification data obtained from thermogravimetric analysis. Data are then compared to predictions from a recently proposed CVI model for fiber bundle densification. 10 refs., 5 figs., 1 tab.

  8. Principal G-bundles on nodal curves

    Indian Academy of Sciences (India)

    Springer Verlag Heidelberg #4 2048 1996 Dec 15 10:16:45

    If Y is reducible these notions depend on parameters a = (a1,...,aI ). The study of G-bundles on Y is done by extending the notion of (generalized) parabolic vector bundles [U1] to generalized parabolic principal G-bundles (called GPGs in short) on the curve C and using the correspondence between them and principal ...

  9. Strategic and welfare implications of bundling

    DEFF Research Database (Denmark)

    Martin, Stephen

    1999-01-01

    A standard oligopoly model of bundling shows that bundling by a firm with a monopoly over one product has a strategic effect because it changes the substitution relationships between the goods among which consumers choose. Bundling in appropriate proportions is privately profitable, reduces rivals...

  10. Monosaccharide templates for de novo designed 4-alpha-helix bundle proteins: template effects in carboproteins

    DEFF Research Database (Denmark)

    Brask, Jesper; Dideriksen, J.M.; Nielsen, John

    2003-01-01

    De novo design and total chemical synthesis of proteins provide powerful approaches to critically test our understanding of protein folding, structure, and stability. The 4-alpha-helix bundle is a frequently studied structure in which four amphiphilic alpha-helical peptide strands form...

  11. The Atiyah bundle and connections on a principal bundle

    Indian Academy of Sciences (India)

    INDRANIL BISWAS. School of Mathematics, Tata Institute of Fundamental Research, Homi Bhabha Road,. Mumbai 400 005 .... (U) on A(EG)(U) and (U, g ⊕ Rd) defined by multiplication. Therefore, the sheaf A(EG) is locally free over FC∞. (M) of rank dim(g ⊕ Rd). Hence. A(EG) defines a C. ∞ vector bundle over M of rank ...

  12. Higher order jet prolongations type gauge natural bundles over vector bundles

    Directory of Open Access Journals (Sweden)

    Jan Kurek

    2004-05-01

    Full Text Available Let $rgeq 3$ and $mgeq 2$ be natural numbers and $E$ be a vector bundle with $m$-dimensional basis. We find all gauge natural bundles ``similar" to the $r$-jet prolongation bundle $J^rE$ of $E$. We also find all gauge natural bundles ``similar" to the vector $r$-tangent bundle $(J^r_{fl}(E,R_0^*$ of $E$.

  13. Multipath packet switch using packet bundling

    DEFF Research Database (Denmark)

    Berger, Michael Stubert

    2002-01-01

    The basic concept of packet bundling is to group smaller packets into larger packets based on, e.g., quality of service or destination within the packet switch. This paper presents novel applications of bundling in packet switching. The larger packets created by bundling are utilized to extend...... switching capacity by use of parallel switch planes. During the bundling operation, packets will experience a delay that depends on the actual implementation of the bundling and scheduling scheme. Analytical results for delay bounds and buffer size requirements are presented for a specific scheduling...

  14. LL-37 induces polymerization and bundling of actin and affects actin structure.

    Directory of Open Access Journals (Sweden)

    Asaf Sol

    Full Text Available Actin exists as a monomer (G-actin which can be polymerized to filaments F-actin that under the influence of actin-binding proteins and polycations bundle and contribute to the formation of the cytoskeleton. Bundled actin from lysed cells increases the viscosity of sputum in lungs of cystic fibrosis patients. The human host defense peptide LL-37 was previously shown to induce actin bundling and was thus hypothesized to contribute to the pathogenicity of this disease. In this work, interactions between actin and the cationic LL-37 were studied by optical, proteolytic and surface plasmon resonance methods and compared to those obtained with scrambled LL-37 and with the cationic protein lysozyme. We show that LL-37 binds strongly to CaATP-G-actin while scrambled LL-37 does not. While LL-37, at superstoichiometric LL-37/actin concentrations polymerizes MgATP-G-actin, at lower non-polymerizing concentrations LL-37 inhibits actin polymerization by MgCl(2 or NaCl. LL-37 bundles Mg-F-actin filaments both at low and physiological ionic strength when in equimolar or higher concentrations than those of actin. The LL-37 induced bundles are significantly less sensitive to increase in ionic strength than those induced by scrambled LL-37 and lysozyme. LL-37 in concentrations lower than those needed for actin polymerization or bundling, accelerates cleavage of both monomer and polymer actin by subtilisin. Our results indicate that the LL-37-actin interaction is partially electrostatic and partially hydrophobic and that a specific actin binding sequence in the peptide is responsible for the hydrophobic interaction. LL-37-induced bundles, which may contribute to the accumulation of sputum in cystic fibrosis, are dissociated very efficiently by DNase-1 and also by cofilin.

  15. Cadherin-23 may be dynamic in hair bundles of the model sea anemone Nematostella vectensis.

    Directory of Open Access Journals (Sweden)

    Pei-Ciao Tang

    Full Text Available Cadherin 23 (CDH23, a component of tip links in hair cells of vertebrate animals, is essential to mechanotransduction by hair cells in the inner ear. A homolog of CDH23 occurs in hair bundles of sea anemones. Anemone hair bundles are located on the tentacles where they detect the swimming movements of nearby prey. The anemone CDH23 is predicted to be a large polypeptide featuring a short exoplasmic C-terminal domain that is unique to sea anemones. Experimentally masking this domain with antibodies or mimicking this domain with free peptide rapidly disrupts mechanotransduction and morphology of anemone hair bundles. The loss of normal morphology is accompanied, or followed by a decrease in F-actin in stereocilia of the hair bundles. These effects were observed at very low concentrations of the reagents, 0.1-10 nM, and within minutes of exposure. The results presented herein suggest that: (1 the interaction between CDH23 and molecular partners on stereocilia of hair bundles is dynamic and; (2 the interaction is crucial for normal mechanotransduction and morphology of hair bundles.

  16. Cadherin-23 may be dynamic in hair bundles of the model sea anemone Nematostella vectensis.

    Science.gov (United States)

    Tang, Pei-Ciao; Watson, Glen M

    2014-01-01

    Cadherin 23 (CDH23), a component of tip links in hair cells of vertebrate animals, is essential to mechanotransduction by hair cells in the inner ear. A homolog of CDH23 occurs in hair bundles of sea anemones. Anemone hair bundles are located on the tentacles where they detect the swimming movements of nearby prey. The anemone CDH23 is predicted to be a large polypeptide featuring a short exoplasmic C-terminal domain that is unique to sea anemones. Experimentally masking this domain with antibodies or mimicking this domain with free peptide rapidly disrupts mechanotransduction and morphology of anemone hair bundles. The loss of normal morphology is accompanied, or followed by a decrease in F-actin in stereocilia of the hair bundles. These effects were observed at very low concentrations of the reagents, 0.1-10 nM, and within minutes of exposure. The results presented herein suggest that: (1) the interaction between CDH23 and molecular partners on stereocilia of hair bundles is dynamic and; (2) the interaction is crucial for normal mechanotransduction and morphology of hair bundles.

  17. Static stress analysis of CANFLEX fuel bundles

    Energy Technology Data Exchange (ETDEWEB)

    Suk, Ho Chun; Kang, Hee Young; Sim, Ki Seop; Jeong, Jang Hwan; Jun, Gi Su; Park, Ju Hwan; Lee, Che Han; Kim, Tae Hyoung [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1996-02-01

    The static stress analysis of CANFLEX bundles is performed to evaluate the fuel structural integrity during the refuelling service. The structure analysis is carried out by predicting the drag force, stress and displacements of the fuel bundle. By the comparison of strength tests and analysis results, the displacement values are well agreed within 15%. The analysis shows that the CANFLEX fuel bundle keep its structural integrity. 24 figs., 6 tabs., 12 refs. (Author) .new.

  18. Hydraulic characteristics of HANARO fuel bundles

    Energy Technology Data Exchange (ETDEWEB)

    Cho, S.; Chung, H. J.; Chun, S. Y.; Yang, S. K.; Chung, M. K. [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1997-12-31

    This paper presents the hydraulic characteristics measured by using LDV (Laser Doppler Velocimetry) in subchannels of HANARO, KAERI research reactor, fuel bundle. The fuel bundle consists of 18 axially finned rods with 3 spacer grids, which are arranged in cylindrical configuration. The effects of the spacer grids on the turbulent flow were investigated by the experimental results. Pressure drops for each component of the fuel bundle were measured, and the friction factors of fuel bundle and loss coefficients for the spacer grids were estimated from the measured pressure drops. Implications regarding the turbulent thermal mixing were discussed. Vibration test results measured by using laser vibrometer were presented. 9 refs., 12 figs. (Author)

  19. Ulrich Schur bundles on flag varieties

    OpenAIRE

    Coskun, Izzet; Costa, Laura; Huizenga, Jack; Miró-Roig, Rosa Maria; Woolf, Matthew

    2015-01-01

    In this paper, we study equivariant vector bundles on partial flag varieties arising from Schur functors. We show that a partial flag variety with three or more steps does not admit an Ulrich bundle of this form with respect to the minimal ample class. We classify Ulrich bundles of this form on two-step flag varieties F(1,n-1;n), F(2,n-1;n), F(2,n-2;n), F(k,k+1;n) and F(k,k+2;n). We give a conjectural description of the two-step flag varieties which admit such Ulrich bundles.

  20. Equivariant Ulrich bundles on flag varieties

    OpenAIRE

    Coskun, Izzet; Huizenga, Jack; Woolf, Matthew

    2015-01-01

    In this paper, we study equivariant vector bundles on partial flag varieties arising from Schur functors. We show that a partial flag variety with three or more steps does not admit an Ulrich bundle of this form with respect to the minimal ample class. We classify Ulrich bundles of this form on two-step flag varieties F(2,n;n+1), F(2,n;n+2), F(k,k+1;n), and F(k,k+2;n). We give a conjectural description of the two-step flag varieties which admit such Ulrich bundles. Our results provide counter...

  1. Axis deviation without left bundle branch block.

    Science.gov (United States)

    Patanè, Salvatore; Marte, Filippo; Mancuso, Antonia

    2010-04-15

    It has been rarely reported changing axis deviation in the presence of left bundle branch block also during atrial fibrillation and with acute myocardial infarction too. It has also been rarely reported changing axis deviation with changing bundle branch block with onset of atrial fibrillation during acute myocardial infarction. We present a case of axis deviation without left bundle branch block and without atrial fibrillation and acute myocardial infarction in a 65-year-old Italian man. To our knowledge, this is the first report of axis deviation without left bundle branch block and without atrial fibrillation and acute myocardial infarction. Copyright 2008 Elsevier Ireland Ltd. All rights reserved.

  2. Why (almost) all bundles are chiral

    Science.gov (United States)

    Kost-Smith, Zachary V.; Blackwell, Robert A.; Glaser, Matthew A.

    2014-03-01

    We examine the self assembly of bundles of achiral hard rods with distributed, short-range attractive interactions. We show that in the majority of cases the equilibrium state of the bundle is chiral, with a double twist structure. We use biased Monte Carlo techniques and cell theory to compute the free energy as a function of an appropriately defined twist order parameter, and show that the formation of spontaneously chiral bundles is driven by maximization of orientational entropy. The finite curvature of the bundle boundary permits orientational escape, in which the circumferential angular range of motion of the rods is maximized for some finite average tilt. We map out the phase diagram of bundles in terms of the density, the ratio of rod length to bundle radius, L / R , and rod aspect ratio, L / D , and find transitions between untwisted, weakly twisted, and strongly twisted states. This work helps explain the common observation of twisted macroscopic bundles, and may provide insight into observations of twist in self-assembled membranes of colloidal rods.[2] This work funded by NSF MRSEC Grant DMR-0820579.

  3. Einstein metrics on tangent bundles of spheres

    Energy Technology Data Exchange (ETDEWEB)

    Dancer, Andrew S [Jesus College, Oxford University, Oxford OX1 3DW (United Kingdom); Strachan, Ian A B [Department of Mathematics, University of Hull, Hull HU6 7RX (United Kingdom)

    2002-09-21

    We give an elementary treatment of the existence of complete Kaehler-Einstein metrics with nonpositive Einstein constant and underlying manifold diffeomorphic to the tangent bundle of the (n+1)-sphere.

  4. Dynamic bi-product bundle pricing problem

    Directory of Open Access Journals (Sweden)

    Rafiei Hamed

    2014-01-01

    Full Text Available This paper addresses bundle pricing problem of two products in a stochastic environment so as to maximize net profit of a retailer. In the considered problem, it is assumed that customers are received upon a Poisson distribution and their demands follow a bi-variant distribution function. Also, it is assumed that products are sold individually or in the form of a bundle, which are offered from an initial stock of the products. To tackle the problem, a stochastic dynamic program is developed in which optimum values of the initial stock and order quantities of every planning period are determined. Moreover, prices of the individual products and their bundle are optimized. Also, the proposed dynamic program tackles bundling/ unbundling decisions taken in every planning period. A numerical example of a two planning period horizon is considered to validate the proposed model.

  5. Is It Complete Left Bundle Branch Block? Just Ablate the Right Bundle.

    Science.gov (United States)

    Ali, Hussam; Lupo, Pierpaolo; Foresti, Sara; De Ambroggi, Guido; Epicoco, Gianluca; Fundaliotis, Angelica; Cappato, Riccardo

    2017-03-01

    Complete left bundle branch block (LBBB) is established according to standard electrocardiographic criteria. However, functional LBBB may be rate-dependent or can perpetuate during tachycardia due to repetitive concealed retrograde penetration of impulses through the contralateral bundle "linking phenomenon." In this brief article, we present two patients with basal complete LBBB in whom ablating the right bundle unmasked the actual antegrade conduction capabilities of the left bundle. These cases highlight intriguing overlap between electrophysiological concepts of complete block, linking, extremely slow, and concealed conduction. © 2016 Wiley Periodicals, Inc.

  6. Physiological mechanisms of QRS narrowing in bundle branch block patients undergoing permanent His bundle pacing.

    Science.gov (United States)

    Teng, Alexandra E; Massoud, Louis; Ajijola, Olujimi A

    2016-01-01

    His bundle pacing is increasingly used to avoid chronic right ventricular pacing, and electrically resynchronize ventricular activation by narrowing or normalizing the QRS interval in left and right bundle branch block. The mechanisms by which this occurs remain poorly understood. In this review, the proposed mechanisms and evidence supporting them are discussed. Also discussed are aspects of mechanisms that are not completely supported by the evidence. We also review the differences and physiological bases for direct vs. indirect His bundle capture, and the physiological mechanisms for QRS narrowing vs. normalization following His bundle pacing. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Biomechanics of the porcine triple bundle anterior cruciate ligament.

    Science.gov (United States)

    Kato, Yuki; Ingham, Sheila J M; Linde-Rosen, Monica; Smolinski, Patrick; Horaguchi, Takashi; Fu, Freddie H

    2010-01-01

    Several species of animals are used as a model to study human anterior cruciate ligament (ACL) reconstruction. In many animals, three bundles were clearly discernible during dissection in the ACL. However, there are few reports about the biomechanical role of each bundle in the porcine knee. The purpose of this study is to investigate the role of each of the three bundles in the porcine knee, especially the intermediate bundle. Ten porcine knees were tested using a robotic/universal forcemoment sensor system. This system applied anterior loading of 89 N at 30 degrees, 60 degrees and 90 degrees of flexion, and a combined 7 Nm valgus and 4 Nm internal tibial torque at 30 degrees and 60 degrees of flexion before and after each bundle was selectively cut. The in situ force (N) for each bundle of the ACL was measured. Both intermediate (IM) bundle and postero-lateral (PL) bundle had significantly lower in situ force than the antero-medial (AM) bundle in anterior loading. The IM and PL bundles carried a larger proportion of the force under the torsional loads than the anterior loads. But IM bundle had a significant lower in situ force during the combined torque at 60 degrees of knee flexion, when compared intact ACL. In summary, IM bundle has a subordinate role to the AM and PL bundles. AM bundle is more dominant than IM and PL bundles. The porcine knee is a suitable model for ACL studies, especially for AP stability.

  8. Stability of Picard bundle over moduli space of stable vector bundles ...

    Indian Academy of Sciences (India)

    Springer Verlag Heidelberg #4 2048 1996 Dec 15 10:16:45

    Stability of Picard bundle over moduli space of stable vector bundles of rank two over a curve. INDRANIL BISWAS and TOM ´AS L G ´OMEZ. School of Mathematics, Tata Institute of Fundamental Research, Homi Bhabha Road,. Mumbai 400 005, India. E-mail: indranil@math.tifr.res.in; tomas@math.tifr.res.in. MS received 14 ...

  9. Stability of Picard bundle over moduli space of stable vector bundles ...

    Indian Academy of Sciences (India)

    Abstract. Answering a question of [BV] it is proved that the Picard bundle on the moduli space of stable vector bundles of rank two, on a Riemann surface of genus at least three, with fixed determinant of odd degree is stable.

  10. Balance Ability and Proprioception after Single-Bundle, Single-Bundle Augmentation, and Double-Bundle ACL Reconstruction

    Directory of Open Access Journals (Sweden)

    Yubao Ma

    2014-01-01

    Full Text Available Purpose. The present study sought to determine the influences of single-bundle (SB, single-bundle augmentation (SBA, and double-bundle (DB reconstructions on balance ability and proprioceptive function. Methods. 67 patients who underwent a single- or double-bundle ACL reconstruction or a SBA using multistranded autologous hamstring tendons were included in this study with a 1-year follow-up. Body sway and knee kinesthesia (using the threshold to detect passive motion test (TTDPM were measured to indicate balance ability and proprioceptive function, respectively. Additionally, within-subject differences in anterior-posterior stability of the tibia and lower extremity muscle strength were evaluated before and after surgery. Results. At 6 and 12 months after surgery, DB reconstruction resulted in better balance and proprioceptive function than SB reconstruction (P<0.05. Although no significant difference was observed in balance ability or proprioceptive function between the SBA and DB reconstructions, knee stability was significantly better with SBA and DB reconstructions than SB reconstruction (P<0.05. No significant differences were found in quadriceps and hamstrings strength among the three reconstruction techniques. Conclusions. Our findings consider that joint stability, proprioceptive function, and balance ability were superior with SBA and DB reconstructions compared to SB reconstruction at 6 and 12 months after surgery.

  11. Graph Bundling by Kernel Density Estimation

    NARCIS (Netherlands)

    Hurter, C.; Ersoy, O.; Telea, A.

    We present a fast and simple method to compute bundled layouts of general graphs. For this, we first transform a given graph drawing into a density map using kernel density estimation. Next, we apply an image sharpening technique which progressively merges local height maxima by moving the convolved

  12. Permanent His-Bundle Pacing: Case Studies.

    Science.gov (United States)

    Vijayaraman, Pugazhendhi; Dandamudi, Gopi

    2016-12-01

    His bundle pacing (HBP) is a physiological alternative to right ventricular pacing. In addition to patients with normal His-Purkinje conduction, HBP can be valuable in patients with infranodal atrioventricular (AV) block and patients undergoing AV node ablation. The following case studies illustrate the challenges associated with HBP. © 2016 Wiley Periodicals, Inc.

  13. Fluxes, bundle gerbes and 2-Hilbert spaces

    Science.gov (United States)

    Bunk, Severin; Szabo, Richard J.

    2017-10-01

    We elaborate on the construction of a prequantum 2-Hilbert space from a bundle gerbe over a 2-plectic manifold, providing the first steps in a programme of higher geometric quantisation of closed strings in flux compactifications and of M5-branes in C-fields. We review in detail the construction of the 2-category of bundle gerbes and introduce the higher geometrical structures necessary to turn their categories of sections into 2-Hilbert spaces. We work out several explicit examples of 2-Hilbert spaces in the context of closed strings and M5-branes on flat space. We also work out the prequantum 2-Hilbert space associated with an M-theory lift of closed strings described by an asymmetric cyclic orbifold of the SU(2) WZW model, providing an example of sections of a torsion gerbe on a curved background. We describe the dimensional reduction of M-theory to string theory in these settings as a map from 2-isomorphism classes of sections of bundle gerbes to sections of corresponding line bundles, which is compatible with the respective monoidal structures and module actions.

  14. The unintended consequences of bundled payments.

    Science.gov (United States)

    Weeks, William B; Rauh, Stephen S; Wadsworth, Eric B; Weinstein, James N

    2013-01-01

    Consensus is building that episode-based bundled payments can produce substantial Medicare savings, and the Center for Medicare & Medicaid Innovation's Bundled Payment Initiative endorses this concept. The program generates potential cost savings by reducing the historic cost of time-defined episodes of care, provided through a discount. Although bundled payments can reduce waste primarily in the postacute care setting, concerns arise that, in an effort to maintain income levels that are necessary to cover fixed costs, providers may change their behaviors to increase the volume of episodes. Such actions would mitigate the savings that Medicare might have accrued and may perpetuate the fee-for-service payment mechanism, with episodes of care becoming the new service. Although bundled payments have some advantages over the current reimbursement system, true cost-savings to Medicare will be realized only when the federal government addresses the use issue that underlies much of the waste inherent in the system and provides ample incentives to eliminate capacity and move toward capitation.

  15. Capacity efficiency of recovery request bundling

    DEFF Research Database (Denmark)

    Ruepp, Sarah Renée; Dittmann, Lars; Berger, Michael Stübert

    2010-01-01

    This paper presents a comparison of recovery methods in terms of capacity efficiency. In particular, a method where recovery requests are bundled towards the destination (Shortcut Span Protection) is evaluated against traditional recovery methods. Our simulation results show that Shortcut Span...

  16. Meromorphic connections on vector bundles over curves

    Indian Academy of Sciences (India)

    Descartes,. 67084 Strasbourg Cedex, France. *Correspond author. E-mail: indranil@math.tifr.res.in; heu@math.unistra.fr. MS received 17 July 2013; revised 20 October 2013. Abstract. We give a criterion for filtered vector bundles over curves to admit a ...

  17. Anterior cruciate ligament reconstruction with double bundle versus single bundle: experimental study

    National Research Council Canada - National Science Library

    Roberto F. Mota e Albuquerque; Sandra Umeda Sasaki; Marco Martins Amatuzzi; Fabio Janson Angelini

    2007-01-01

    OBJECTIVE: To test an intra-articular reconstruction of the anterior cruciate ligament of the knee in 10 human cadavers by replacing 2 anterior cruciate ligament bundles, with the purpose of producing...

  18. Functional aspects of His bundle physiology and pathophysiology: Clinical implications.

    Science.gov (United States)

    Scherlag, Benjamin J; Lazzara, Ralph

    In this review we present evidence from many experimental studies which challenge the concept of predestination of His bundle fibers. Using both intra- and extracellular His bundle pacing in the context of atrio-ventricular block and the development of bundle branch blocks these experimental studies provide the underlying mechanisms for the recent clinical findings showing the benefits of permanent His bundle pacing. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. A case of 'Masquerading' bundle branch block: a forgotten concept.

    Science.gov (United States)

    Choudhary, Dinesh; Namboodiri, Narayanan; Tharakan, Jaganmohan A

    2014-01-01

    'Masquerading' bundle branch block (right bundle branch block in the precordial leads with left bundle branch block in frontal leads and left axis deviation) is seen most commonly with coronary artery disease and hypertension. No definite explanation is available so far for these changes. We are presenting a case of rare congenital intranuclear inclusion myopathy with congestive heart failure and 'Masquerading' bundle branch block in ECG. Copyright © 2013 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.

  20. Bundling revisited: substitute products and inter-firm discounts

    OpenAIRE

    Armstrong, Mark

    2010-01-01

    This paper extends the standard model of bundling to allow products to be substitutes and for products to be supplied by separate sellers. Whether integrated or separate, firms have an incentive to introduce bundling discounts when demand for the bundle is elastic relative to demand for stand-alone products. When products are partial substitutes, this typically gives an integrated firm a greater incentive to offer a bundle discount (relative to the standard model with additive preferences), w...

  1. Modular Design of Self-Assembling Peptide-Based Nanotubes.

    Science.gov (United States)

    Burgess, Natasha C; Sharp, Thomas H; Thomas, Franziska; Wood, Christopher W; Thomson, Andrew R; Zaccai, Nathan R; Brady, R Leo; Serpell, Louise C; Woolfson, Derek N

    2015-08-26

    An ability to design peptide-based nanotubes (PNTs) rationally with defined and mutable internal channels would advance understanding of peptide self-assembly, and present new biomaterials for nanotechnology and medicine. PNTs have been made from Fmoc dipeptides, cyclic peptides, and lock-washer helical bundles. Here we show that blunt-ended α-helical barrels, that is, preassembled bundles of α-helices with central channels, can be used as building blocks for PNTs. This approach is general and systematic, and uses a set of de novo helical bundles as standards. One of these bundles, a hexameric α-helical barrel, assembles into highly ordered PNTs, for which we have determined a structure by combining cryo-transmission electron microscopy, X-ray fiber diffraction, and model building. The structure reveals that the overall symmetry of the peptide module plays a critical role in ripening and ordering of the supramolecular assembly. PNTs based on pentameric, hexameric, and heptameric α-helical barrels sequester hydrophobic dye within their lumens.

  2. Compactifications of reductive groups as moduli stacks of bundles

    DEFF Research Database (Denmark)

    Martens, Johan; Thaddeus, Michael

    Let G be a reductive group. We introduce the moduli problem of "bundle chains" parametrizing framed principal G-bundles on chains of lines. Any fan supported in a Weyl chamber determines a stability condition on bundle chains. Its moduli stack provides an equivariant toroidal compactification of ...... studied by Losev-Manin....

  3. Turkish and Native English Academic Writers' Use of Lexical Bundles

    Science.gov (United States)

    Öztürk, Yusuf; Köse, Gül Durmusoglu

    2016-01-01

    Lexical bundles such as "on the other hand" and "as a result of" are extremely common and important in academic discourse. The appropriate use of lexical bundles typical of a specific academic discipline is important for writers and the absence of such bundles may not sound fluent and native-like. Recent studies (e.g. Adel…

  4. Quillen bundle and geometric prequantization of non-abelian ...

    Indian Academy of Sciences (India)

    In this paper we prequantize the moduli space of non-abelian vortices. We explicitly calculate the symplectic form arising from 2 metric and we construct a prequantum line bundle whose curvature is proportional to this symplectic form. The prequantum line bundle turns out to be Quillen's determinant line bundle with a ...

  5. The Bundle of His in Prosthetic Heart Valve Replacement*

    African Journals Online (AJOL)

    1973-01-27

    Jan 27, 1973 ... ventricular seplUm which transected the bundle of His. Blocks were then fashioned backwards and forwards.. to include the whole of the bundle and the AV node. as well as the bifurcation of the bundle into its left and right branches. According to Davies: in order to study the whole conduction system in an ...

  6. Real parabolic vector bundles over a real curve

    Indian Academy of Sciences (India)

    weights are integral multiples of 1/N, and the category of real -equivariant vector bundles on (Y,σY ). ... The notion of parabolic vector bundles over a compact Riemann surface was introduced by Seshadri [4] and their .... stable. If F is a direct sum of stable vector bundles having the same slope, then F is called polystable.

  7. Geometry of torus bundles in integrable Hamiltonian systems

    NARCIS (Netherlands)

    Lukina, Olga

    2008-01-01

    Thesis is concerned with global properties of Lagrangian bundles, i.e. symplectic n-torus bundles, as these occur in integrable Hamiltonian systems. It treats obstructions to triviality and concerns with classification of such bundles, as well as with manifestations of global invariants in

  8. Masquerading bundle branch block: a variety of right bundle branch block with left anterior fascicular block.

    Science.gov (United States)

    Elizari, Marcelo V; Baranchuk, Adrian; Chiale, Pablo A

    2013-01-01

    The so-called 'masquerading' type of right bundle branch block is caused by the simultaneous presence of a high-degree left anterior fascicular block often accompanied with severe left ventricular enlargement and/or fibrotic block in the anterolateral wall of the left ventricle. These conditions tend to reorient the terminal electrical forces of the QRS complex towards the left and upwards, in such a way that the characteristic slurred S wave in lead I becomes smaller or even disappears. In many cases of standard masquerading right bundle branch block, a small Q wave in lead I is present due to the initial forces of the left anterior fascicular block, which are oriented rightwards and inferiorly. However, in some cases, the Q wave in lead I also vanishes, and the mimicking of a left bundle branch block becomes perfect in standard leads. This is commonly associated with an inferior myocardial infarction or severe inferior fibrosis in cardiomyopathies. The typical QRS changes of right bundle branch block may eventually be concealed even in the right precordial leads; under such circumstances, the ECG diagnosis may be mistaken and the right bundle branch block totally missed. The masquerading right bundle branch block carries a poor prognosis, since it always implies the presence of a severe underlying heart disease.

  9. Bundling of harvesting residues and whole-trees and the treatment of bundles; Hakkuutaehteiden ja kokopuiden niputus ja nippujen kaesittely

    Energy Technology Data Exchange (ETDEWEB)

    Kaipainen, H.; Seppaenen, V.; Rinne, S.

    1996-12-31

    The conditions on which the bundling of the harvesting residues from spruce regeneration fellings would become profitable were studied. The calculations showed that one of the most important features was sufficient compaction of the bundle, so that the portion of the wood in the unit volume of the bundle has to be more than 40 %. The tests showed that the timber grab loader of farm tractor was insufficient for production of dense bundles. The feeding and compression device of the prototype bundler was constructed in the research and with this device the required density was obtained.The rate of compaction of the dry spruce felling residues was about 40 % and that of the fresh residues was more than 50 %. The comparison between the bundles showed that the calorific value of the fresh bundle per unit volume was nearly 30 % higher than that of the dry bundle. This means that the treatment of the bundles should be done of fresh felling residues. Drying of the bundles succeeded well, and the crushing and chipping tests showed that the processing of the bundles at the plant is possible. The treatability of the bundles was also excellent. By using the prototype, developed in the research, it was possible to produce a bundle of the fresh spruce harvesting residues, the diameter of which was about 50 cm and the length about 3 m, and the rate of compaction over 50 %. By these values the reduction target of the costs is obtainable

  10. A de novo designed monomeric, compact three helix bundle protein on a carbohydrate template

    DEFF Research Database (Denmark)

    Malik, Leila; Nygård, Jesper; Christensen, Niels Johan

    2015-01-01

    proteins, so called carboproteins. The hypothesis is that the template pre-organizes the secondary structure elements and directs the formation of a tertiary structure, thus achieving structural economy in the combination of peptide, linker, and template. We speculate that the structural information from...... the template could facilitate protein folding. Here we report the design and synthesis of 3-helix bundle carboproteins on deoxy-hexopyranosides. The carboproteins were analyzed by CD, AUC, SAXS, and NMR, which revealed the formation of the first compact, and folded monomeric carboprotein distinctly different...

  11. Baseline left bundle branch block with right bundle branch escape complexes in a patient with coronary artery disease, presents like an alternating bundle branch block: a case report

    Science.gov (United States)

    Bhimaraj, Arvind; Abusin, Salaheldin; Margeta, Bosko

    2008-01-01

    Alternating bundle branch block (ABBB) is a less commonly encountered phenomenon with the advent of re-perfusion therapy for acute myocardial infarction. ECGs simulating the appearance of an ABBB need to be carefully analysed. We present an ECG showing a baseline Left Bundle Branch Block(LBBB) progressing to a high grade AV block with escape complexes having a Right Bundle Branch Block (RBBB) morphology. Such an ECG can be mistaken for an ABBB if not analysed carefully. PMID:19116014

  12. Bioactive Peptides

    Directory of Open Access Journals (Sweden)

    Eric Banan-Mwine Daliri

    2017-04-01

    Full Text Available The increased consumer awareness of the health promoting effects of functional foods and nutraceuticals is the driving force of the functional food and nutraceutical market. Bioactive peptides are known for their high tissue affinity, specificity and efficiency in promoting health. For this reason, the search for food-derived bioactive peptides has increased exponentially. Over the years, many potential bioactive peptides from food have been documented; yet, obstacles such as the need to establish optimal conditions for industrial scale production and the absence of well-designed clinical trials to provide robust evidence for proving health claims continue to exist. Other important factors such as the possibility of allergenicity, cytotoxicity and the stability of the peptides during gastrointestinal digestion would need to be addressed. This review discusses our current knowledge on the health effects of food-derived bioactive peptides, their processing methods and challenges in their development.

  13. Bioactive Peptides.

    Science.gov (United States)

    Daliri, Eric Banan-Mwine; Oh, Deog H; Lee, Byong H

    2017-04-26

    The increased consumer awareness of the health promoting effects of functional foods and nutraceuticals is the driving force of the functional food and nutraceutical market. Bioactive peptides are known for their high tissue affinity, specificity and efficiency in promoting health. For this reason, the search for food-derived bioactive peptides has increased exponentially. Over the years, many potential bioactive peptides from food have been documented; yet, obstacles such as the need to establish optimal conditions for industrial scale production and the absence of well-designed clinical trials to provide robust evidence for proving health claims continue to exist. Other important factors such as the possibility of allergenicity, cytotoxicity and the stability of the peptides during gastrointestinal digestion would need to be addressed. This review discusses our current knowledge on the health effects of food-derived bioactive peptides, their processing methods and challenges in their development.

  14. Non-abelian higher gauge theory and categorical bundle

    Science.gov (United States)

    Viennot, David

    2016-12-01

    A gauge theory is associated with a principal bundle endowed with a connection permitting to define horizontal lifts of paths. The horizontal lifts of surfaces cannot be defined into a principal bundle structure. An higher gauge theory is an attempt to generalize the bundle structure in order to describe horizontal lifts of surfaces. A such attempt is particularly difficult for the non-abelian case. Some structures have been proposed to realize this goal (twisted bundle, gerbes with connection, bundle gerbe, 2-bundle). Each of them uses a category in place of the total space manifold of the usual principal bundle structure. Some of them replace also the structure group by a category (more precisely a Lie crossed module viewed as a category). But the base space remains still a simple manifold (possibly viewed as a trivial category with only identity arrows). We propose a new principal categorical bundle structure, with a Lie crossed module as structure groupoid, but with a base space belonging to a bigger class of categories (which includes non-trivial categories), that we called affine 2-spaces. We study the geometric structure of the categorical bundles built on these categories (which are a more complicated structure than the 2-bundles) and the connective structures on these bundles. Finally we treat an example interesting for quantum dynamics which is associated with the Bloch wave operator theory.

  15. SIKAP KONSUMEN TERHADAP PRODUK BUNDLING AGRIBISNIS

    Directory of Open Access Journals (Sweden)

    Didi Junaedi

    2017-04-01

    implementation to Dekalb brand hybrid corn and Round-up brand herbicide. By analyzes how consumer attitudes toward buying intention in this regard farmers as buyer and retailers as products services. The data used is primary data. Primary data is obtained using 2 kind of respondents are retailers and farmers. The data obtained by distributed 30 questionnaires for retailers and 110 farmers in Grobogan. The descriptive statistic employed to analyzed data by using multiple linear regressions with t test, F test and coefficient of determination. The result showed that on retailers respondents attribute the product bundling has no significant influence to consumer buying intention but consumer attitudes significantly influence the buying intention. On the farmers respondents showed that attributes of the product bundling and consumer attitudes positive and significant influence to buying intention.

  16. Covariance and the hierarchy of frame bundles

    Science.gov (United States)

    Estabrook, Frank B.

    1987-01-01

    This is an essay on the general concept of covariance, and its connection with the structure of the nested set of higher frame bundles over a differentiable manifold. Examples of covariant geometric objects include not only linear tensor fields, densities and forms, but affinity fields, sectors and sector forms, higher order frame fields, etc., often having nonlinear transformation rules and Lie derivatives. The intrinsic, or invariant, sets of forms that arise on frame bundles satisfy the graded Cartan-Maurer structure equations of an infinite Lie algebra. Reduction of these gives invariant structure equations for Lie pseudogroups, and for G-structures of various orders. Some new results are introduced for prolongation of structure equations, and for treatment of Riemannian geometry with higher-order moving frames. The use of invariant form equations for nonlinear field physics is implicitly advocated.

  17. Client Provider Collaboration for Service Bundling

    Directory of Open Access Journals (Sweden)

    LETIA, I. A.

    2008-04-01

    Full Text Available The key requirement for a service industry organization to reach competitive advantages through product diversification is the existence of a well defined method for building service bundles. Based on the idea that the quality of a service or its value is given by the difference between expectations and perceptions, we draw the main components of a frame that aims to support the client and the provider agent in an active collaboration meant to co-create service bundles. Following e3-value model, we structure the supporting knowledge around the relation between needs and satisfying services. We deal with different perspectives about quality through an ontological extension of Value Based Argumentation. The dialog between the client and the provider takes the form of a persuasion whose dynamic object is the current best configuration. Our approach for building service packages is a demand driven approach, allowing progressive disclosure of private knowledge.

  18. Uncovering Ecosystem Service Bundles through Social Preferences

    Science.gov (United States)

    Martín-López, Berta; Iniesta-Arandia, Irene; García-Llorente, Marina; Palomo, Ignacio; Casado-Arzuaga, Izaskun; Amo, David García Del; Gómez-Baggethun, Erik; Oteros-Rozas, Elisa; Palacios-Agundez, Igone; Willaarts, Bárbara; González, José A.; Santos-Martín, Fernando; Onaindia, Miren; López-Santiago, Cesar; Montes, Carlos

    2012-01-01

    Ecosystem service assessments have increasingly been used to support environmental management policies, mainly based on biophysical and economic indicators. However, few studies have coped with the social-cultural dimension of ecosystem services, despite being considered a research priority. We examined how ecosystem service bundles and trade-offs emerge from diverging social preferences toward ecosystem services delivered by various types of ecosystems in Spain. We conducted 3,379 direct face-to-face questionnaires in eight different case study sites from 2007 to 2011. Overall, 90.5% of the sampled population recognized the ecosystem’s capacity to deliver services. Formal studies, environmental behavior, and gender variables influenced the probability of people recognizing the ecosystem’s capacity to provide services. The ecosystem services most frequently perceived by people were regulating services; of those, air purification held the greatest importance. However, statistical analysis showed that socio-cultural factors and the conservation management strategy of ecosystems (i.e., National Park, Natural Park, or a non-protected area) have an effect on social preferences toward ecosystem services. Ecosystem service trade-offs and bundles were identified by analyzing social preferences through multivariate analysis (redundancy analysis and hierarchical cluster analysis). We found a clear trade-off among provisioning services (and recreational hunting) versus regulating services and almost all cultural services. We identified three ecosystem service bundles associated with the conservation management strategy and the rural-urban gradient. We conclude that socio-cultural preferences toward ecosystem services can serve as a tool to identify relevant services for people, the factors underlying these social preferences, and emerging ecosystem service bundles and trade-offs. PMID:22720006

  19. Twisted vector bundles on pointed nodal curves

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    DEFINITION 2.5. Let C → S be an n-pointed nodal curve over a k-scheme S and let ξ be a principal G- bundle on Cgen. A chart (U, η, ) for ξ is called balanced, if for each ... branches is via multiplication with primitive roots of unity which are inverse to each other. ...... Condition (16) implies that A0 is a block matrix of the form.

  20. Principal bundles on the projective line

    Indian Academy of Sciences (India)

    M. Senthilkumar (Newgen Imaging) 1461 1996 Oct 15 13:05:22

    LetX be a complete nonsingular curve over the algebraic closurek ofk andGa reductive group over k. Let E → X be a principal G-bundle on X. E is said to be semistable if, for every reduction of structure group EP ⊂ E to a maximal parabolic subgroup P of G, we have degree EP (p) ≤ 0, where p is the Lie algebra of P and EP ...

  1. Abelian conformal field theory and determinant bundles

    DEFF Research Database (Denmark)

    Andersen, Jørgen Ellegaard; Ueno, K.

    2007-01-01

    are up to a scale the same as the curvature of the connections constructed in [14, 16]. We study the sewing construction for nodal curves and its explicit relation to the constructed connections. Finally we construct preferred holomorphic sections of these line bundles and analyze their behaviour near...... nodal curves. These results are used in [4] to construct modular functors form the conformal field theories given in [14, 16] by twisting with an appropriate factional power of this Abelian theory....

  2. Uncovering ecosystem service bundles through social preferences.

    Directory of Open Access Journals (Sweden)

    Berta Martín-López

    Full Text Available Ecosystem service assessments have increasingly been used to support environmental management policies, mainly based on biophysical and economic indicators. However, few studies have coped with the social-cultural dimension of ecosystem services, despite being considered a research priority. We examined how ecosystem service bundles and trade-offs emerge from diverging social preferences toward ecosystem services delivered by various types of ecosystems in Spain. We conducted 3,379 direct face-to-face questionnaires in eight different case study sites from 2007 to 2011. Overall, 90.5% of the sampled population recognized the ecosystem's capacity to deliver services. Formal studies, environmental behavior, and gender variables influenced the probability of people recognizing the ecosystem's capacity to provide services. The ecosystem services most frequently perceived by people were regulating services; of those, air purification held the greatest importance. However, statistical analysis showed that socio-cultural factors and the conservation management strategy of ecosystems (i.e., National Park, Natural Park, or a non-protected area have an effect on social preferences toward ecosystem services. Ecosystem service trade-offs and bundles were identified by analyzing social preferences through multivariate analysis (redundancy analysis and hierarchical cluster analysis. We found a clear trade-off among provisioning services (and recreational hunting versus regulating services and almost all cultural services. We identified three ecosystem service bundles associated with the conservation management strategy and the rural-urban gradient. We conclude that socio-cultural preferences toward ecosystem services can serve as a tool to identify relevant services for people, the factors underlying these social preferences, and emerging ecosystem service bundles and trade-offs.

  3. Uncovering ecosystem service bundles through social preferences.

    Science.gov (United States)

    Martín-López, Berta; Iniesta-Arandia, Irene; García-Llorente, Marina; Palomo, Ignacio; Casado-Arzuaga, Izaskun; Amo, David García Del; Gómez-Baggethun, Erik; Oteros-Rozas, Elisa; Palacios-Agundez, Igone; Willaarts, Bárbara; González, José A; Santos-Martín, Fernando; Onaindia, Miren; López-Santiago, Cesar; Montes, Carlos

    2012-01-01

    Ecosystem service assessments have increasingly been used to support environmental management policies, mainly based on biophysical and economic indicators. However, few studies have coped with the social-cultural dimension of ecosystem services, despite being considered a research priority. We examined how ecosystem service bundles and trade-offs emerge from diverging social preferences toward ecosystem services delivered by various types of ecosystems in Spain. We conducted 3,379 direct face-to-face questionnaires in eight different case study sites from 2007 to 2011. Overall, 90.5% of the sampled population recognized the ecosystem's capacity to deliver services. Formal studies, environmental behavior, and gender variables influenced the probability of people recognizing the ecosystem's capacity to provide services. The ecosystem services most frequently perceived by people were regulating services; of those, air purification held the greatest importance. However, statistical analysis showed that socio-cultural factors and the conservation management strategy of ecosystems (i.e., National Park, Natural Park, or a non-protected area) have an effect on social preferences toward ecosystem services. Ecosystem service trade-offs and bundles were identified by analyzing social preferences through multivariate analysis (redundancy analysis and hierarchical cluster analysis). We found a clear trade-off among provisioning services (and recreational hunting) versus regulating services and almost all cultural services. We identified three ecosystem service bundles associated with the conservation management strategy and the rural-urban gradient. We conclude that socio-cultural preferences toward ecosystem services can serve as a tool to identify relevant services for people, the factors underlying these social preferences, and emerging ecosystem service bundles and trade-offs.

  4. Bundling harvester; Harvennuspuun automaattisen nippukorjausharvesterin kehittaeminen

    Energy Technology Data Exchange (ETDEWEB)

    Koponen, K. [Eko-Log Oy, Kuopio (Finland)

    1997-12-01

    The starting point of the project was to design and construct, by taking the silvicultural point of view into account, a harvesting and processing system especially for energy-wood, containing manually driven bundling harvester, automating of the harvester, and automated loading. The equipment forms an ideal method for entrepreneur`s-line harvesting. The target is to apply the system also for owner`s-line harvesting. The profitability of the system promotes the utilisation of the system in both cases. The objectives of the project were: to construct a test equipment and prototypes for all the project stages, to carry out terrain and strain tests in order to examine the usability and durability, as well as the capacity of the machine, to test the applicability of the Eko-Log system in simultaneous harvesting of energy and pulp woods, and to start the marketing and manufacturing of the products. The basic problems of the construction of the bundling harvester have been solved using terrain-tests. The prototype machine has been shown to be operable. Loading of the bundles to form sufficiently economically transportable loads has been studied, and simultaneously, the branch-biomass has been tried to be utilised without loosing the profitability of transportation. The results have been promising, and will promote the profitable utilisation of wood-energy. (orig.)

  5. An analytical fiber bundle model for pullout mechanics of root bundles

    Science.gov (United States)

    Cohen, D.; Schwarz, M.; Or, D.

    2011-09-01

    Roots in soil contribute to the mechanical stability of slopes. Estimation of root reinforcement is challenging because roots form complex biological networks whose geometrical and mechanical characteristics are difficult to characterize. Here we describe an analytical model that builds on simple root descriptors to estimate root reinforcement. Root bundles are modeled as bundles of heterogeneous fibers pulled along their long axes neglecting root-soil friction. Analytical expressions for the pullout force as a function of displacement are derived. The maximum pullout force and corresponding critical displacement are either derived analytically or computed numerically. Key model inputs are a root diameter distribution (uniform, Weibull, or lognormal) and three empirical power law relations describing tensile strength, elastic modulus, and length of roots as functions of root diameter. When a root bundle with root tips anchored in the soil matrix is pulled by a rigid plate, a unique parameter, ?, that depends only on the exponents of the power law relations, dictates the order in which roots of different diameters break. If ? 1, large roots break first. When ? = 1, all fibers break simultaneously, and the maximum tensile force is simply the roots' mean force times the number of roots in the bundle. Based on measurements of root geometry and mechanical properties, the value of ? is less than 1, usually ranging between 0 and 0.7. Thus, small roots always fail first. The model shows how geometrical and mechanical characteristics of roots and root diameter distribution affect the pullout force, its maximum and corresponding displacement. Comparing bundles of roots that have similar mean diameters, a bundle with a narrow variance in root diameter will result in a larger maximum force and a smaller displacement at maximum force than a bundle with a wide diameter distribution. Increasing the mean root diameter of a bundle without changing the distribution's shape increases

  6. Peptide YY.

    Science.gov (United States)

    Chandarana, Keval; Batterham, Rachel

    2008-02-01

    This review discusses recent studies examining the effects of peptide YY on energy homeostasis, highlights the emerging hedonic effects of peptide YY and evaluates the therapeutic potential of the peptide YY system. A role for exogenous PYY3-36 as an anorectic agent in obese humans and rodents has been established and weight loss effects demonstrated in obese rodents. New lines of evidence support a role for endogenous peptide YY in regulating energy homeostasis. The NPY-Y2 receptor mediates the anorectic actions of PYY3-36 with rodent studies implicating the hypothalamus, vagus and brainstem as key target sites. Functional imaging in humans has confirmed that PYY3-36 activates brainstem and hypothalamic regions. The greatest effects, however, were observed within the orbitofrontal cortex, a brain region involved in reward processing. Further evidence for a hedonic role for PYY3-36 is supported by rodent studies showing that PYY3-36 decreases the motivation to seek high-fat food. Rodent studies using selective Y2 agonists and strategies combining PYY3-36/Y2 agonists with other anorectic agents have revealed increased anorectic and weight-reducing effects. Peptide YY plays a role in the integrative regulation of metabolism. The emerging hedonic effects of peptide YY together with the weight-reducing effects observed in obese rodents suggest that targeting the peptide YY system may offer a therapeutic strategy for obesity.

  7. Influence of Bundle Diameter and Attachment Point on Kinematic Behavior in Double Bundle Anterior Cruciate Ligament Reconstruction Using Computational Model

    Directory of Open Access Journals (Sweden)

    Oh Soo Kwon

    2014-01-01

    Full Text Available A protocol to choose the graft diameter attachment point of each bundle has not yet been determined since they are usually dependent on a surgeon’s preference. Therefore, the influence of bundle diameters and attachment points on the kinematics of the knee joint needs to be quantitatively analyzed. A three-dimensional knee model was reconstructed with computed tomography images of a 26-year-old man. Based on the model, models of double bundle anterior cruciate ligament (ACL reconstruction were developed. The anterior tibial translations for the anterior drawer test and the internal tibial rotation for the pivot shift test were investigated according to variation of bundle diameters and attachment points. For the model in this study, the knee kinematics after the double bundle ACL reconstruction were dependent on the attachment point and not much influenced by the bundle diameter although larger sized anterior-medial bundles provided increased stability in the knee joint. Therefore, in the clinical setting, the bundle attachment point needs to be considered prior to the bundle diameter, and the current selection method of graft diameters for both bundles appears justified.

  8. Monopoles and Modifications of Bundles over Elliptic Curves

    Directory of Open Access Journals (Sweden)

    Andrey M. Levin

    2009-06-01

    Full Text Available Modifications of bundles over complex curves is an operation that allows one to construct a new bundle from a given one. Modifications can change a topological type of bundle. We describe the topological type in terms of the characteristic classes of the bundle. Being applied to the Higgs bundles modifications establish an equivalence between different classical integrable systems. Following Kapustin and Witten we define the modifications in terms of monopole solutions of the Bogomolny equation. We find the Dirac monopole solution in the case R × (elliptic curve. This solution is a three-dimensional generalization of the Kronecker series. We give two representations for this solution and derive a functional equation for it generalizing the Kronecker results. We use it to define Abelian modifications for bundles of arbitrary rank. We also describe non-Abelian modifications in terms of theta-functions with characteristic.

  9. Trivalent Cation Induced Bundle Formation of Filamentous fd Phages.

    Science.gov (United States)

    Korkmaz Zirpel, Nuriye; Park, Eun Jin

    2015-09-01

    Bacteriophages are filamentous polyelectrolyte viral rods infecting only bacteria. In this study, we investigate the bundle formation of fd phages with trivalent cations having different ionic radii (Al(3+) , La(3+) and Y(3+) ) at various phage and counterion concentrations, and at varying bundling times. Aggregated phage bundles were detected at relatively low trivalent counterion concentrations (1 mM). Although 10 mM and 100 mM Y(3+) and La(3+) treatments formed larger and more intertwined phage bundles, Al(3+) and Fe(3+) treatments lead to the formation of networking filaments. Energy dispersive X-ray spectroscopy (EDX) analyses confirmed the presence of C, N and O peaks on densely packed phage bundles. Immunofluorescence labelling and ELISA analyses with anti-p8 antibodies showed the presence of phage filaments after bundling. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Heat Transfer Analysis in Wire Bundles for Aerospace Vehicles

    Science.gov (United States)

    Rickman, S. L.; Iamello, C. J.

    2016-01-01

    Design of wiring for aerospace vehicles relies on an understanding of "ampacity" which refers to the current carrying capacity of wires, either, individually or in wire bundles. Designers rely on standards to derate allowable current flow to prevent exceedance of wire temperature limits due to resistive heat dissipation within the wires or wire bundles. These standards often add considerable margin and are based on empirical data. Commercial providers are taking an aggressive approach to wire sizing which challenges the conventional wisdom of the established standards. Thermal modelling of wire bundles may offer significant mass reduction in a system if the technique can be generalized to produce reliable temperature predictions for arbitrary bundle configurations. Thermal analysis has been applied to the problem of wire bundles wherein any or all of the wires within the bundle may carry current. Wire bundles present analytical challenges because the heat transfer path from conductors internal to the bundle is tortuous, relying on internal radiation and thermal interface conductance to move the heat from within the bundle to the external jacket where it can be carried away by convective and radiative heat transfer. The problem is further complicated by the dependence of wire electrical resistivity on temperature. Reduced heat transfer out of the bundle leads to higher conductor temperatures and, hence, increased resistive heat dissipation. Development of a generalized wire bundle thermal model is presented and compared with test data. The steady state heat balance for a single wire is derived and extended to the bundle configuration. The generalized model includes the effects of temperature varying resistance, internal radiation and thermal interface conductance, external radiation and temperature varying convective relief from the free surface. The sensitivity of the response to uncertainties in key model parameters is explored using Monte Carlo analysis.

  11. Isomonodromic Deformations and Very Stable Vector Bundles of Rank Two

    Science.gov (United States)

    Biswas, Indranil; Heu, Viktoria; Hurtubise, Jacques

    2017-12-01

    For the universal isomonodromic deformation of an irreducible logarithmic rank two connection over a smooth complex projective curve of genus at least two, consider the family of holomorphic vector bundles over curves underlying this universal deformation. In a previous work we proved that the vector bundle corresponding to a general parameter of this family is stable. Here we prove that the vector bundle corresponding to a general parameter is in fact very stable, meaning it does not admit any nonzero nilpotent Higgs field.

  12. Bundling Products and Services Through Modularization Strategies

    DEFF Research Database (Denmark)

    Bask, Anu; Hsuan, Juliana; Rajahonka, Mervi

    2012-01-01

    Modularity has been recognized as a powerful tool in improving the efficiency and management of product design and manufacturing. However, the integrated view on covering both, product and service modularity for product-service systems (PSS), is under researched. Therefore, in this paper our...... objective is to contribute to the PSS modularity. Thus, we describe configurations of PSSs and the bundling of products and services through modularization strategies. So far there have not been tools to analyze and determine the correct combinations of degrees of product and service modularities....

  13. Differential geometry bundles, connections, metrics and curvature

    CERN Document Server

    Taubes, Clifford Henry

    2011-01-01

    Bundles, connections, metrics and curvature are the 'lingua franca' of modern differential geometry and theoretical physics. This book will supply a graduate student in mathematics or theoretical physics with the fundamentals of these objects. Many of the tools used in differential topology are introduced and the basic results about differentiable manifolds, smooth maps, differential forms, vector fields, Lie groups, and Grassmanians are all presented here. Other material covered includes the basic theorems about geodesics and Jacobi fields, the classification theorem for flat connections, the

  14. Affine Flag Manifolds and Principal Bundles

    CERN Document Server

    Schmitt, Alexander HW

    2010-01-01

    Affine flag manifolds are infinite dimensional versions of familiar objects such as Gramann varieties. The book features lecture notes, survey articles, and research notes - based on workshops held in Berlin, Essen, and Madrid - explaining the significance of these and related objects (such as double affine Hecke algebras and affine Springer fibers) in representation theory (e.g., the theory of symmetric polynomials), arithmetic geometry (e.g., the fundamental lemma in the Langlands program), and algebraic geometry (e.g., affine flag manifolds as parameter spaces for principal bundles). Novel

  15. Vector bundles on complex projective spaces

    CERN Document Server

    Okonek, Christian; Spindler, Heinz

    1980-01-01

    This expository treatment is based on a survey given by one of the authors at the Séminaire Bourbaki in November 1978 and on a subsequent course held at the University of Göttingen. It is intended to serve as an introduction to the topical question of classification of holomorphic vector bundles on complex projective spaces, and can easily be read by students with a basic knowledge of analytic or algebraic geometry. Short supplementary sections describe more advanced topics, further results, and unsolved problems.

  16. Discontinuous conduction in mouse bundle branches is caused by bundle-branch architecture

    NARCIS (Netherlands)

    van Veen, Toon A. B.; van Rijen, Harold V. M.; van Kempen, Marjan J. A.; Miquerol, Lucile; Opthof, Tobias; Gros, Daniel; Vos, Marc A.; Jongsma, Habo J.; de Bakker, Jacques M. T.

    2005-01-01

    Background - Recordings of the electrical activity of mouse bundle branches ( BBs) suggest reduced conduction velocity ( CV) in the midseptal compared with the proximal part of the BB. The present study was performed to elucidate the mechanism responsible for this slowing of conduction. Methods and

  17. Enthalpy and void distributions in subchannels of PHWR fuel bundles

    Energy Technology Data Exchange (ETDEWEB)

    Park, J. W.; Choi, H.; Rhee, B. W. [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1998-12-31

    Two different types of the CANDU fuel bundles have been modeled for the ASSERT-IV code subchannel analysis. From calculated values of mixture enthalpy and void fraction distribution in the fuel bundles, it is found that net buoyancy effect is pronounced in the central region of the DUPIC fuel bundle when compared with the standard CANDU fuel bundle. It is also found that the central region of the DUPIC fuel bundle can be cooled more efficiently than that of the standard fuel bundle. From the calculated mixture enthalpy distribution at the exit of the fuel channel, it is found that the mixture enthalpy and void fraction can be highest in the peripheral region of the DUPIC fuel bundle. On the other hand, the enthalpy and the void fraction were found to be highest in the central region of the standard CANDU fuel bundle at the exit of the fuel channel. This study shows that the subchannel analysis is very useful in assessing thermal behavior of the fuel bundle that could be used in CANDU reactors. 10 refs., 4 figs., 2 tabs. (Author)

  18. Molybdenum-99-producing 37-element fuel bundle neutronically and thermal-hydraulically equivalent to a standard CANDU fuel bundle

    Energy Technology Data Exchange (ETDEWEB)

    Nichita, E., E-mail: Eleodor.Nichita@uoit.ca; Haroon, J., E-mail: Jawad.Haroon@uoit.ca

    2016-10-15

    Highlights: • A 37-element fuel bundle modified for {sup 99}Mo production in CANDU reactors is presented. • The modified bundle is neutronically and thermal-hydraulically equivalent to the standard bundle. • The modified bundle satisfies all safety criteria satisfied by the standard bundle. - Abstract: {sup 99m}Tc, the most commonly used radioisotope in diagnostic nuclear medicine, results from the radioactive decay of {sup 99}Mo which is currently being produced at various research reactors around the globe. In this study, the potential use of CANDU power reactors for the production of {sup 99}Mo is investigated. A modified 37-element fuel bundle, suitable for the production of {sup 99}Mo in existing CANDU-type reactors is proposed. The new bundle is specifically designed to be neutronically and thermal-hydraulically equivalent to the standard 37-element CANDU fuel bundle in normal, steady-state operation and, at the same time, be able to produce significant quantities of {sup 99}Mo when irradiated in a CANDU reactor. The proposed bundle design uses fuel pins consisting of a depleted-uranium centre surrounded by a thin layer of low-enriched uranium. The new molybdenum-producing bundle is analyzed using the lattice transport code DRAGON and the diffusion code DONJON. The proposed design is shown to produce 4081 six-day Curies of {sup 99}Mo activity per bundle when irradiated in the peak-power channel of a CANDU core, while maintaining the necessary reactivity and power rating limits. The calculated {sup 99}Mo yield corresponds to approximately one third of the world weekly demand. A production rate of ∼3 bundles per week can meet the global demand of {sup 99}Mo.

  19. Design and evaluate finned tube bundles

    Energy Technology Data Exchange (ETDEWEB)

    Ganapathy, V. [ABCO Industries, Abilene, TX (United States)

    1996-09-01

    Finned tube bundles are widely used in heat exchangers, air coolers, waste heat boilers and fired heaters where energy transfer occurs between clean flue gases and a fluid with a high heat-transfer coefficient. They have several advantages including compactness, low gas pressure drop and low weight for a given duty compared to bare tube bundles. Choosing a fin type, arrangement and fin configuration requires a thorough analysis and economic evaluation. The solution is not unique since it depends on material and labor costs. Surface areas vary widely in finned tube designs for the same duty and gas pressure drop. Therefore, decisions should not be based on surface area alone. Plant engineers and consultants should consider operating costs in their evaluation because they accrue year after year. Selecting a boiler based on initial costs alone is not prudent. The paper discusses heat transfer and gas pressure drop with finned tubes, determining fin efficiency and effectiveness,g as pressure drop, tube wall and fin top temperatures, an example calculation, the effect of fin configuration on design, the effect of inline versus staggered arrangements and solid versus serrated fins, and concerns with high fin-density designs.

  20. Development boiling to sprinkled tube bundle

    Directory of Open Access Journals (Sweden)

    Kracík Petr

    2016-01-01

    Full Text Available This paper presents results of a studied heat transfer coefficient at the surface of a sprinkled tube bundle where boiling occurs. Research in the area of sprinkled exchangers can be divided into two major parts. The first part is research on heat transfer and determination of the heat transfer coefficient at sprinkled tube bundles for various liquids, whether boiling or not. The second part is testing of sprinkle modes for various tube diameters, tube pitches and tube materials and determination of individual modes’ interface. All results published so far for water as the falling film liquid apply to one to three tubes for which the mentioned relations studied are determined in rigid laboratory conditions defined strictly in advance. The sprinkled tubes were not viewed from the operational perspective where there are more tubes and various modes may occur in different parts with various heat transfer values. The article focuses on these processes. The tube is located in a low-pressure chamber where vacuum is generated using an exhauster via ejector. The tube consists of smooth copper tubes of 12 mm diameter placed horizontally one above another.

  1. Evaluation of Single-Bundle versus Double-Bundle PCL Reconstructions with More Than 10-Year Follow-Up

    Directory of Open Access Journals (Sweden)

    Masataka Deie

    2015-01-01

    Full Text Available Background. Posterior cruciate ligament (PCL injuries are not rare in acute knee injuries, and several recent anatomical studies of the PCL and reconstructive surgical techniques have generated improved patient results. Now, we have evaluated PCL reconstructions performed by either the single-bundle or double-bundle technique in a patient group followed up retrospectively for more than 10 years. Methods. PCL reconstructions were conducted using the single-bundle (27 cases or double-bundle (13 cases method from 1999 to 2002. The mean age at surgery was 34 years in the single-bundle group and 32 years in the double-bundle group. The mean follow-up period was 12.5 years. Patients were evaluated by Lysholm scoring, the gravity sag view, and knee arthrometry. Results. The Lysholm score after surgery was 89.1±5.6 points for the single-bundle group and 91.9±4.5 points for the double-bundle group. There was no significant difference between the methods in the side-to-side differences by gravity sag view or knee arthrometer evaluation, although several cases in both groups showed a side-to-side difference exceeding 5 mm by the latter evaluation method. Conclusions. We found no significant difference between single- and double-bundle PCL reconstructions during more than 10 years of follow-up.

  2. An integral Riemann-Roch theorem for surface bundles

    DEFF Research Database (Denmark)

    Madsen, Ib Henning

    2010-01-01

    This paper is a response to a conjecture by T. Akita about an integral Riemann–Roch theorem for surface bundles.......This paper is a response to a conjecture by T. Akita about an integral Riemann–Roch theorem for surface bundles....

  3. Restriction Theorem for Principal bundles in Arbitrary Characteristic

    DEFF Research Database (Denmark)

    Gurjar, Sudarshan

    2015-01-01

    The aim of this paper is to prove two basic restriction theorem for principal bundles on smooth projective varieties in arbitrary characteristic generalizing the analogues theorems of Mehta-Ramanathan for vector bundles. More precisely, let G be a reductive algebraic group over an algebraically c...

  4. Phase Space Reduction of Star Products on Cotangent Bundles.

    NARCIS (Netherlands)

    Kowalzig, N.; Neumaier, N.; Pflaum, M.

    2005-01-01

    In this paper we construct star products on Marsden-Weinstein reduced spaces in case both the original phase space and the reduced phase space are (symplectomorphic to) cotangent bundles. Under the assumption that the original cotangent bundle $T^*Q$ carries a symplectic structure of form

  5. Monoubiquitination Inhibits the Actin Bundling Activity of Fascin.

    Science.gov (United States)

    Lin, Shengchen; Lu, Shuang; Mulaj, Mentor; Fang, Bin; Keeley, Tyler; Wan, Lixin; Hao, Jihui; Muschol, Martin; Sun, Jianwei; Yang, Shengyu

    2016-12-30

    Fascin is an actin bundling protein that cross-links individual actin filaments into straight, compact, and stiff bundles, which are crucial for the formation of filopodia, stereocillia, and other finger-like membrane protrusions. The dysregulation of fascin has been implicated in cancer metastasis, hearing loss, and blindness. Here we identified monoubiquitination as a novel mechanism that regulates fascin bundling activity and dynamics. The monoubiquitination sites were identified to be Lys247 and Lys250, two residues located in a positive charge patch at the actin binding site 2 of fascin. Using a chemical ubiquitination method, we synthesized chemically monoubiquitinated fascin and determined the effects of monoubiquitination on fascin bundling activity and dynamics. Our data demonstrated that monoubiquitination decreased the fascin bundling EC50, delayed the initiation of bundle assembly, and accelerated the disassembly of existing bundles. By analyzing the electrostatic properties on the solvent-accessible surface of fascin, we proposed that monoubiquitination introduced steric hindrance to interfere with the interaction between actin filaments and the positively charged patch at actin binding site 2. We also identified Smurf1 as a E3 ligase regulating the monoubiquitination of fascin. Our findings revealed a previously unidentified regulatory mechanism for fascin, which will have important implications for the understanding of actin bundle regulation under physiological and pathological conditions. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  6. Lexical Bundles in L1 and L2 Academic Writing

    Science.gov (United States)

    Chen, Yu-Hua; Baker, Paul

    2010-01-01

    This paper adopts an automated frequency-driven approach to identify frequently-used word combinations (i.e., "lexical bundles") in academic writing. Lexical bundles retrieved from one corpus of published academic texts and two corpora of student academic writing (one L1, the other L2), were investigated both quantitatively and qualitatively.…

  7. Lexical Bundles: Facilitating University "Talk" in Group Discussions

    Science.gov (United States)

    Heng, Chan Swee; Kashiha, Hadi; Tan, Helen

    2014-01-01

    Group discussion forms an integral language experience for most language learners, providing them with an opportunity to express themselves in a naturalistic setting. Multi-word expressions are commonly used and one of them is lexical bundles. Lexical bundles are types of extended collocations that occur more commonly than we expect; they are…

  8. A novel microbond bundle pullout technique to evaluate the ...

    Indian Academy of Sciences (India)

    2017-07-26

    Jul 26, 2017 ... to be a need to develop a microbond bundle pullout test that is comparable in all aspects to the semi-empirical resin slab/fibre bundle pullout approach [9]. The improvement of the known draw backs of the single fibre microbond pullout method [7], such as the difficulty in formulation and testing (with lack.

  9. Hair bundles are specialized for ATP delivery via creatine kinase.

    NARCIS (Netherlands)

    Shin, J.B.; Streijger, F.; Beynon, A.J.; Peters, T.; Gadzala, L.; McMillen, D.; Bystrom, C.; Zee, C.E.E.M. van der; Wallimann, T.; Gillespie, P.G.

    2007-01-01

    When stimulated strongly, a hair cell's mechanically sensitive hair bundle may consume ATP too rapidly for replenishment by diffusion. To provide a broad view of the bundle's protein complement, including those proteins participating in energy metabolism, we used shotgun mass spectrometry methods to

  10. Smooth Bundling of Large Streaming and Sequence Graphs

    NARCIS (Netherlands)

    Hurter, C.; Ersoy, O.; Telea, A.

    2013-01-01

    Dynamic graphs are increasingly pervasive in modern information systems. However, understanding how a graph changes in time is difficult. We present here two techniques for simplified visualization of dynamic graphs using edge bundles. The first technique uses a recent image-based graph bundling

  11. Computational imaging through a fiber-optic bundle

    Science.gov (United States)

    Lodhi, Muhammad A.; Dumas, John Paul; Pierce, Mark C.; Bajwa, Waheed U.

    2017-05-01

    Compressive sensing (CS) has proven to be a viable method for reconstructing high-resolution signals using low-resolution measurements. Integrating CS principles into an optical system allows for higher-resolution imaging using lower-resolution sensor arrays. In contrast to prior works on CS-based imaging, our focus in this paper is on imaging through fiber-optic bundles, in which manufacturing constraints limit individual fiber spacing to around 2 μm. This limitation essentially renders fiber-optic bundles as low-resolution sensors with relatively few resolvable points per unit area. These fiber bundles are often used in minimally invasive medical instruments for viewing tissue at macro and microscopic levels. While the compact nature and flexibility of fiber bundles allow for excellent tissue access in-vivo, imaging through fiber bundles does not provide the fine details of tissue features that is demanded in some medical situations. Our hypothesis is that adapting existing CS principles to fiber bundle-based optical systems will overcome the resolution limitation inherent in fiber-bundle imaging. In a previous paper we examined the practical challenges involved in implementing a highly parallel version of the single-pixel camera while focusing on synthetic objects. This paper extends the same architecture for fiber-bundle imaging under incoherent illumination and addresses some practical issues associated with imaging physical objects. Additionally, we model the optical non-idealities in the system to get lower modelling errors.

  12. Frobenius pull backs of vector bundles in higher dimensions

    Indian Academy of Sciences (India)

    Frobenius pull backs; instability degree, vector bundles. 1. Introduction. Let X be a nonsingular projective variety defined over an algebraically closed field k of an arbitrary characteristic, and let H be a very ample line bundle on X. Let E be a torsion free sheaf on X. Then the notion of E being stable (resp. semistable) is well- ...

  13. On Harder–Narasimhan reductions for Higgs principal bundles

    Indian Academy of Sciences (India)

    in Ramanathan's paper. The aim of this paper is to generalize the methods of Biswas and Holla to give a unified approach to the case of principal bundles with Higgs structure on smooth projective varieties as well as the case of ramified bundles on smooth curves [4] (see §2, §5 for definitions). Recall that for the case of ...

  14. [Bundle-branch block depending on the heart rate].

    Science.gov (United States)

    Apostolov, L

    1975-01-01

    Five patients are reported, admitted to the hospital, with diseases predominantly of the cardio-vascular system. During the electrocardiographic examinations bundle branch block was established, depending on heart rate. It fluctuated within the physiological limits from 50 to 90/min. In three of the patients, the bundle branch block appeared with the quickening of the heart rate (tachycardia-depending bundle branch block) and in two of the patients--the bundle branch block appeared during the slowing down of the heart action and disappeared with its quickening (bradicardia-depending bundle branch block). A brief literature review is presented and attention is paid to the possible diagnostic errors and the treatment mode of those patients with cardiac tonic and antiarrhythmic medicaments.

  15. Bundles over Quantum RealWeighted Projective Spaces

    Directory of Open Access Journals (Sweden)

    Tomasz Brzeziński

    2012-09-01

    Full Text Available The algebraic approach to bundles in non-commutative geometry and the definition of quantum real weighted projective spaces are reviewed. Principal U(1-bundles over quantum real weighted projective spaces are constructed. As the spaces in question fall into two separate classes, the negative or odd class that generalises quantum real projective planes and the positive or even class that generalises the quantum disc, so do the constructed principal bundles. In the negative case the principal bundle is proven to be non-trivial and associated projective modules are described. In the positive case the principal bundles turn out to be trivial, and so all the associated modules are free. It is also shown that the circle (coactions on the quantum Seifert manifold that define quantum real weighted projective spaces are almost free.

  16. Artificial ciliary bundles with nano fiber tip links

    CERN Document Server

    Asadnia, Mohsen; Miao, Jianmin; Triantafyllou, Michael

    2015-01-01

    Mechanosensory ciliary bundles in fishes are the inspiration for carefully engineered artificial flow sensors. We report the development of a new class of ultrasensitive MEMS flow sensors that mimic the intricate morphology of the ciliary bundles, including the stereocilia, tip links, and the cupula, and thereby achieve threshold detection limits that match the biological example. An artificial ciliary bundle is achieved by fabricating closely-spaced arrays of polymer micro-pillars with gradiating heights. Tip links that form the fundamental sensing elements are realized through electrospinning aligned PVDF piezoelectric nano-fibers that link the distal tips of the polymer cilia. An optimized synthesis of hyaluronic acid-methacrylic anhydride hydrogel that results in properties close to the biological cupula, together with drop-casting method are used to form the artificial cupula that encapsulates the ciliary bundle. In testing, fluid drag force causes the ciliary bundle to slide, stretching the flexible nan...

  17. Superconductivity in an Inhomogeneous Bundle of Metallic and Semiconducting Nanotubes

    Directory of Open Access Journals (Sweden)

    Ilya Grigorenko

    2013-01-01

    Full Text Available Using Bogoliubov-de Gennes formalism for inhomogeneous systems, we have studied superconducting properties of a bundle of packed carbon nanotubes, making a triangular lattice in the bundle's transverse cross-section. The bundle consists of a mixture of metallic and doped semiconducting nanotubes, which have different critical transition temperatures. We investigate how a spatially averaged superconducting order parameter and the critical transition temperature depend on the fraction of the doped semiconducting carbon nanotubes in the bundle. Our simulations suggest that the superconductivity in the bundle will be suppressed when the fraction of the doped semiconducting carbon nanotubes will be less than 0.5, which is the percolation threshold for a two-dimensional triangular lattice.

  18. Framework for shape analysis of white matter fiber bundles.

    Science.gov (United States)

    Glozman, Tanya; Bruckert, Lisa; Pestilli, Franco; Yecies, Derek W; Guibas, Leonidas J; Yeom, Kristen W

    2017-12-02

    Diffusion imaging coupled with tractography algorithms allows researchers to image human white matter fiber bundles in-vivo. These bundles are three-dimensional structures with shapes that change over time during the course of development as well as in pathologic states. While most studies on white matter variability focus on analysis of tissue properties estimated from the diffusion data, e.g. fractional anisotropy, the shape variability of white matter fiber bundle is much less explored. In this paper, we present a set of tools for shape analysis of white matter fiber bundles, namely: (1) a concise geometric model of bundle shapes; (2) a method for bundle registration between subjects; (3) a method for deformation estimation. Our framework is useful for analysis of shape variability in white matter fiber bundles. We demonstrate our framework by applying our methods on two datasets: one consisting of data for 6 normal adults and another consisting of data for 38 normal children of age 11 days to 8.5 years. We suggest a robust and reproducible method to measure changes in the shape of white matter fiber bundles. We demonstrate how this method can be used to create a model to assess age-dependent changes in the shape of specific fiber bundles. We derive such models for an ensemble of white matter fiber bundles on our pediatric dataset and show that our results agree with normative human head and brain growth data. Creating these models for a large pediatric longitudinal dataset may improve understanding of both normal development and pathologic states and propose novel parameters for the examination of the pediatric brain. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. Bundling of elastic filaments induced by hydrodynamic interactions

    Science.gov (United States)

    Man, Yi; Page, William; Poole, Robert J.; Lauga, Eric

    2017-12-01

    Peritrichous bacteria swim in viscous fluids by rotating multiple helical flagellar filaments. As the bacterium swims forward, all its flagella rotate in synchrony behind the cell in a tight helical bundle. When the bacterium changes its direction, the flagellar filaments unbundle and randomly reorient the cell for a short period of time before returning to their bundled state and resuming swimming. This rapid bundling and unbundling is, at its heart, a mechanical process whereby hydrodynamic interactions balance with elasticity to determine the time-varying deformation of the filaments. Inspired by this biophysical problem, we present in this paper what is perhaps the simplest model of bundling whereby two or more straight elastic filaments immersed in a viscous fluid rotate about their centerline, inducing rotational flows which tend to bend the filaments around each other. We derive an integrodifferential equation governing the shape of the filaments resulting from mechanical balance in a viscous fluid at low Reynolds number. We show that such equation may be evaluated asymptotically analytically in the long-wavelength limit, leading to a local partial differential equation governed by a single dimensionless bundling number. A numerical study of the dynamics predicted by the model reveals the presence of two configuration instabilities with increasing bundling numbers: first to a crossing state where filaments touch at one point and then to a bundled state where filaments wrap along each other in a helical fashion. We also consider the case of multiple filaments and the unbundling dynamics. We next provide an intuitive physical model for the crossing instability and show that it may be used to predict analytically its threshold and adapted to address the transition to a bundling state. We then use a macroscale experimental implementation of the two-filament configuration in order to validate our theoretical predictions and obtain excellent agreement. This long

  20. Restriction of Preferences to the Set of Consumption Bundles, In a Model with Production and Consumption Bundles

    NARCIS (Netherlands)

    Schalk, S.

    1999-01-01

    In contrast to the neo-classical theory of Arrow and Debreu, a model of a private ownership economy is presented, in which production and consumption bundles are treated separately. Each of the two types of bundles is assumed to establish a con- vex cone. Production technologies can convert

  1. Single-Bundle Versus Double-Bundle Reconstruction for Anterior Cruciate Ligament Rupture: A Meta-Analysis-Does Anatomy Matter?

    NARCIS (Netherlands)

    Eck, Carola F. Van; Kopf, Sebastian; Irrgang, James J.; Blankevoort, Leendert; Bhandari, Mohit; Fu, Freddie H.; Poolman, Rudolf W.

    2012-01-01

    Purpose: To determine whether double-bundle anterior cruciate ligament reconstruction leads to better restoration of anterior and rotational laxity and range of motion than single-bundle reconstruction. Methods: A search was performed in the Medline, Embase, CINAHL, and Cochrane databases. All

  2. Cost-effectiveness of a central venous catheter care bundle.

    Directory of Open Access Journals (Sweden)

    Kate A Halton

    Full Text Available BACKGROUND: A bundled approach to central venous catheter care is currently being promoted as an effective way of preventing catheter-related bloodstream infection (CR-BSI. Consumables used in the bundled approach are relatively inexpensive which may lead to the conclusion that the bundle is cost-effective. However, this fails to consider the nontrivial costs of the monitoring and education activities required to implement the bundle, or that alternative strategies are available to prevent CR-BSI. We evaluated the cost-effectiveness of a bundle to prevent CR-BSI in Australian intensive care patients. METHODS AND FINDINGS: A Markov decision model was used to evaluate the cost-effectiveness of the bundle relative to remaining with current practice (a non-bundled approach to catheter care and uncoated catheters, or use of antimicrobial catheters. We assumed the bundle reduced relative risk of CR-BSI to 0.34. Given uncertainty about the cost of the bundle, threshold analyses were used to determine the maximum cost at which the bundle remained cost-effective relative to the other approaches to infection control. Sensitivity analyses explored how this threshold alters under different assumptions about the economic value placed on bed-days and health benefits gained by preventing infection. If clinicians are prepared to use antimicrobial catheters, the bundle is cost-effective if national 18-month implementation costs are below $1.1 million. If antimicrobial catheters are not an option the bundle must cost less than $4.3 million. If decision makers are only interested in obtaining cash-savings for the unit, and place no economic value on either the bed-days or the health benefits gained through preventing infection, these cost thresholds are reduced by two-thirds. CONCLUSIONS: A catheter care bundle has the potential to be cost-effective in the Australian intensive care setting. Rather than anticipating cash-savings from this intervention, decision

  3. Bundling Actin Filaments From Membranes: Some Novel Players

    Directory of Open Access Journals (Sweden)

    Clément eThomas

    2012-08-01

    Full Text Available Progress in live-cell imaging of the cytoskeleton has significantly extended our knowledge about the organization and dynamics of actin filaments near the plasma membrane of plant cells. Noticeably, two populations of filamentous structures can be distinguished. On the one hand, fine actin filaments which exhibit an extremely dynamic behavior basically characterized by fast polymerization and prolific severing events, a process referred to as actin stochastic dynamics. On the other hand, thick actin bundles which are composed of several filaments and which are comparatively more stable although they constantly remodel as well. There is evidence that the actin cytoskeleton plays critical roles in trafficking and signaling at both the cell cortex and organelle periphery but the exact contribution of actin bundles remains unclear. A common view is that actin bundles provide the long-distance tracks used by myosin motors to deliver their cargo to growing regions and accordingly play a particularly important role in cell polarization. However, several studies support that actin bundles are more than simple passive highways and display multiple and dynamic roles in the regulation of many processes, such as cell elongation, polar auxin transport, stomatal and chloroplast movement, and defense against pathogens. The list of identified plant actin-bundling proteins is ever expanding, supporting that plant cells shape structurally and functionally different actin bundles. Here I review the most recently characterized actin-bundling proteins, with a particular focus on those potentially relevant to membrane trafficking and/or signaling.

  4. Aerosol retention in the flooded steam generator bundle during SGTR

    Energy Technology Data Exchange (ETDEWEB)

    Lind, Terttaliisa, E-mail: terttaliisa.lind@psi.c [Paul Scherrer Institut, Department of Nuclear Energy and Safety, 5232 Villigen (Switzerland); Dehbi, Abdel; Guentay, Salih [Paul Scherrer Institut, Department of Nuclear Energy and Safety, 5232 Villigen (Switzerland)

    2011-01-15

    Research highlights: High retention of aerosol particles in a steam generator bundle flooded with water. Increasing particle inertia, i.e., particle size and velocity, increases retention. Much higher retention of aerosol particles in the steam generator bundle flooded with water than in a dry bundle. Much higher retention of aerosol particles in the steam generator bundle than in a bare pool. Bare pool models have to be adapted to be applicable for flooded bundles. - Abstract: A steam generator tube rupture in a pressurized water reactor may cause accidental release of radioactive particles into the environment. Its specific significance is in its potential to bypass the containment thereby providing a direct pathway of the radioactivity from the primary circuit to the environment. Under certain severe accident scenarios, the steam generator bundle may be flooded with water. In addition, some severe accident management procedures are designed to minimize the release of radioactivity into the environment by flooding the defective steam generator secondary side with water when the steam generator has dried out. To extend our understanding of the particle retention phenomena in the flooded steam generator bundle, tests were conducted in the ARTIST and ARTIST II programs to determine the effect of different parameters on particle retention. The effects of particle type (spherical or agglomerate), particle size, gas mass flow rate, and the break submergence on particle retention were investigated. Results can be summarized as follows: increasing particle inertia was found to increase retention in the flooded bundle. Particle shape, i.e., agglomerate or spherical structure, did not affect retention significantly. Even with a very low submergence, 0.3 m above the tube break, significant aerosol retention took place underlining the importance of the jet-bundle interactions close to the tube break. Droplets were entrained from the water surface with high gas flow rates

  5. Dendro-dendritic bundling and shared synapses between gonadotropin-releasing hormone neurons

    Science.gov (United States)

    Campbell, Rebecca E.; Gaidamaka, Galina; Han, Seong-Kyu; Herbison, Allan E.

    2009-01-01

    The pulsatile release of gonadotropin-releasing hormone (GnRH) is critical for mammalian fertility, but the mechanisms underlying the synchronization of GnRH neurons are unknown. In the present study, the full extent of the GnRH neuron dendritic tree was visualized by patching and filling individual GnRH neurons with biocytin in acute brain slices from adult GnRH-green fluorescent protein (GFP) transgenic mice. Confocal analysis of 42 filled GnRH neurons from male and female adult mice revealed that the dendrites of the great majority of GnRH neurons (86%) formed multiple close appositions with dendrites of other GnRH neurons. Two types of interactions were encountered; the predominant interaction was one of vertical dendritic bundling where dendrites were found to wrap around each other in the same axis. The other interaction was one in which a GnRH neuron dendrite intercepted other GnRH neuron dendrites in a perpendicular fashion. Electron microscopy using pre-embedded, silver-enhanced immunogold labeling for both GnRH and GFP peptides in GnRH-GFP transgenic mice, confirmed that GnRH neuron dendrites were often immediately juxtaposed. Membrane specializations, including punctae and zonula adherens, were found connecting adjacent dendritic elements of GnRH neurons. Remarkably, individual afferent axon terminals were found to synapse with multiple GnRH neuron dendrites at sites of bundling. Together, these data demonstrate that GnRH neurons are not isolated from one another but, rather, interconnected via their long dendritic extensions. The observation of shared synaptic input to bundled GnRH neuron dendrites suggests a mechanism of GnRH neuron synchronization. PMID:19541658

  6. Dark-field illuminated reflectance fiber bundle endoscopic microscope

    Science.gov (United States)

    Liu, Xuan; Huang, Yong; Kang, Jin U.

    2011-04-01

    We propose a reflectance fiber bundle microscope using a dark-field illumination configuration for applications in endoscopic medical imaging and diagnostics. Our experiment results show that dark-field illumination can effectively suppress strong specular reflection from the proximal end of the fiber bundle. We realized a lateral resolution of 4.4 μm using the dark-field illuminated fiber bundle configuration. To demonstrate the feasibility of using the system to study cell morphology, we obtained still and video images of two thyroid cancer cell lines. Our results clearly allow differentiation of different cancer cell types.

  7. Moduli of Parabolic Higgs Bundles and Atiyah Algebroids

    DEFF Research Database (Denmark)

    Logares, Marina; Martens, Johan

    2010-01-01

    In this paper we study the geometry of the moduli space of (non-strongly) parabolic Higgs bundles over a Riemann surface with marked points. We show that this space possesses a Poisson structure, extending the one on the dual of an Atiyah algebroid over the moduli space of parabolic vector bundles....... By considering the case of full flags, we get a Grothendieck–Springer resolution for all other flag types, in particular for the moduli spaces of twisted Higgs bundles, as studied by Markman and Bottacin and used in the recent work of Laumon–Ngô. We discuss the Hitchin system, and demonstrate that all...

  8. Spatial attributes of the four-helix bundle group of bacteriocins – The high-resolution structure of BacSp222 in solution

    KAUST Repository

    Nowakowski, Michał

    2017-11-01

    BacSp222 is a multifunctional bacteriocin produced by Staphylococcus pseudintermedius strain 222, an opportunistic pathogen of domestic animals. At micromolar concentrations, BacSp222 kills Gram-positive bacteria and is cytotoxic toward mammalian cells, while at nanomolar doses, it acts as an immunomodulatory factor, enhancing nitric oxide release in macrophage-like cell lines. The bacteriocin is a cationic, N-terminally formylated, 50-amino-acid-long linear peptide that is rich in tryptophan residues.In this study, the solution structure of BacSp222 was determined and compared to the currently known structures of similar bacteriocins. BacSp222 was isolated from a liquid culture medium in a uniformly 13C- and 15N-labeled form, and NMR data were collected. The structure was calculated based on NMR-derived constraints and consists of a rigid and tightly packed globular bundle of four alpha-helices separated by three short turns.Although the amino acid sequence of BacSp222 has no significant similarity to any known peptide or protein, a 3D structure similarity search indicates a close relation to other four-helix bundle-motif bacteriocins, such as aureocin A53, lacticin Q and enterocins 7A/7B. Assuming similar functions, biology, structure and physicochemical properties, we propose to distinguish the four-helix bundle bacteriocins as a new Type A in subclass IId of bacteriocins, containing linear, non-pediocin-like peptides.

  9. Simulation of finite size effects of the fiber bundle model

    Science.gov (United States)

    Hao, Da-Peng; Tang, Gang; Xun, Zhi-Peng; Xia, Hui; Han, Kui

    2018-01-01

    In theory, the macroscopic fracture of materials should correspond with the thermodynamic limit of the fiber bundle model. However, the simulation of a fiber bundle model with an infinite size is unrealistic. To study the finite size effects of the fiber bundle model, fiber bundle models of various size are simulated in detail. The effects of system size on the constitutive behavior, critical stress, maximum avalanche size, avalanche size distribution, and increased step number of external load are explored. The simulation results imply that there is no feature size or cut size for macroscopic mechanical and statistical properties of the model. The constitutive curves near the macroscopic failure for various system size can collapse well with a simple scaling relationship. Simultaneously, the introduction of a simple extrapolation method facilitates the acquisition of more accurate simulation results in a large-limit system, which is better for comparison with theoretical results.

  10. Improved Conjugate Gradient Bundle Adjustment of Dunhuang Wall Painting Images

    Science.gov (United States)

    Hu, K.; Huang, X.; You, H.

    2017-09-01

    Bundle adjustment with additional parameters is identified as a critical step for precise orthoimage generation and 3D reconstruction of Dunhuang wall paintings. Due to the introduction of self-calibration parameters and quasi-planar constraints, the structure of coefficient matrix of the reduced normal equation is banded-bordered, making the solving process of bundle adjustment complex. In this paper, Conjugate Gradient Bundle Adjustment (CGBA) method is deduced by calculus of variations. A preconditioning method based on improved incomplete Cholesky factorization is adopt to reduce the condition number of coefficient matrix, as well as to accelerate the iteration rate of CGBA. Both theoretical analysis and experimental results comparison with conventional method indicate that, the proposed method can effectively conquer the ill-conditioned problem of normal equation and improve the calculation efficiency of bundle adjustment with additional parameters considerably, while maintaining the actual accuracy.

  11. Bundles of Norms About Teen Sex and Pregnancy.

    Science.gov (United States)

    Mollborn, Stefanie; Sennott, Christie

    2015-09-01

    Teen pregnancy is a cultural battleground in struggles over morality, education, and family. At its heart are norms about teen sex, contraception, pregnancy, and abortion. Analyzing 57 interviews with college students, we found that "bundles" of related norms shaped the messages teens hear. Teens did not think their communities encouraged teen sex or pregnancy, but normative messages differed greatly, with either moral or practical rationalizations. Teens readily identified multiple norms intended to regulate teen sex, contraception, abortion, childbearing, and the sanctioning of teen parents. Beyond influencing teens' behavior, norms shaped teenagers' public portrayals and post hoc justifications of their behavior. Although norm bundles are complex to measure, participants could summarize them succinctly. These bundles and their conflicting behavioral prescriptions create space for human agency in negotiating normative pressures. The norm bundles concept has implications for teen pregnancy prevention policies and can help revitalize social norms for understanding health behaviors. © The Author(s) 2014.

  12. Some applications on tangent bundle with Kaluza-Klein metric

    Directory of Open Access Journals (Sweden)

    Murat Altunbaş

    2017-01-01

    Full Text Available In this paper, differential equations of geodesics; parallelism, incompressibility and closeness conditions of the horizontal and complete lift of the vector fields are investigated with respect to Kaluza-Klein metric on tangent bundle.

  13. Algebraic Frobenius splitting of cotangent bundles of flag varieties

    National Research Council Canada - National Science Library

    Hague, Chuck

    2013-01-01

    Following the program of algebraic Frobenius splitting begun by Kumar and Littelmann, we use representation-theoretic techniques to construct a Frobenius splitting of the cotangent bundle of the flag...

  14. Design and synthesis of DNA four-helix bundles.

    Science.gov (United States)

    Rangnekar, Abhijit; Gothelf, Kurt V; LaBean, Thomas H

    2011-06-10

    The field of DNA nanotechnology has evolved significantly in the past decade. Researchers have succeeded in synthesizing tile-based structures and using them to form periodic lattices in one, two and three dimensions. Origami-based structures have also been used to create nanoscale structures in two and three dimensions. Design and construction of DNA bundles with fixed circumference has added a new dimension to the field. Here we report the design and synthesis of a DNA four-helix bundle. It was found to be extremely rigid and stable. When several such bundles were assembled using appropriate sticky-ends, they formed micrometre-long filaments. However, when creation of two-dimensional sheet-like arrays of the four-helix bundles was attempted, nanoscale rings were observed instead. The exact reason behind the nanoring formation is yet to be ascertained, but it provides an exciting prospect for making programmable circular nanostructures using DNA.

  15. IMPROVED CONJUGATE GRADIENT BUNDLE ADJUSTMENT OF DUNHUANG WALL PAINTING IMAGES

    Directory of Open Access Journals (Sweden)

    K. Hu

    2017-09-01

    Full Text Available Bundle adjustment with additional parameters is identified as a critical step for precise orthoimage generation and 3D reconstruction of Dunhuang wall paintings. Due to the introduction of self-calibration parameters and quasi-planar constraints, the structure of coefficient matrix of the reduced normal equation is banded-bordered, making the solving process of bundle adjustment complex. In this paper, Conjugate Gradient Bundle Adjustment (CGBA method is deduced by calculus of variations. A preconditioning method based on improved incomplete Cholesky factorization is adopt to reduce the condition number of coefficient matrix, as well as to accelerate the iteration rate of CGBA. Both theoretical analysis and experimental results comparison with conventional method indicate that, the proposed method can effectively conquer the ill-conditioned problem of normal equation and improve the calculation efficiency of bundle adjustment with additional parameters considerably, while maintaining the actual accuracy.

  16. CANFLEX fuel bundle cross-flow endurance test (test report)

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Sung Deok; Chung, C. H.; Chang, S. K.; Kim, B. D.

    1997-04-01

    As part of the normal refuelling sequence of CANDU nuclear reactor, both new and irradiated bundles can be parked in the cross-flow region of the liner tubes. This situation occurs normally for a few minutes. The fuel bundle which is subjected to the cross-flow should be capable of withstanding the consequences of cross flow for normal periods, and maintain its mechanical integrity. The cross-flow endurance test was conducted for CANFLEX bundle, latest developed nuclear fuel, at CANDU-Hot Test Loop. The test was carried out during 4 hours at the inlet cross-flow region. After the test, the bundle successfully met all acceptance criteria after the 4 hours cross-flow test. (author). 2 refs., 3 tabs.

  17. Introductory lectures on fibre bundles and topology for physicists

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, G.H.

    1978-05-01

    These lectures may provide useful background material for understanding gauge theories, particularly the nonperturbative effects such as instantons and monopoles. The mathematical language of topology and fibre bundles is introduced.

  18. Bohr--Sommerfeld Lagrangians of moduli spaces of Higgs bundles

    DEFF Research Database (Denmark)

    Biswas, Indranil; Gammelgaard, Niels Leth; Logares, Marina

    Let $X$ be a compact connected Riemann surface of genus at least two. Let $M_H(r,d)$ denote the moduli space of semistable Higgs bundles on $X$ of rank $r$ and degree $d$. We prove that the compact complex Bohr-Sommerfeld Lagrangians of $M_H(r,d)$ are precisely the irreducible components of the n......Let $X$ be a compact connected Riemann surface of genus at least two. Let $M_H(r,d)$ denote the moduli space of semistable Higgs bundles on $X$ of rank $r$ and degree $d$. We prove that the compact complex Bohr-Sommerfeld Lagrangians of $M_H(r,d)$ are precisely the irreducible components...... of the nilpotent cone in $M_H(r,d)$. This generalizes to Higgs $G$-bundles and also to the parabolic Higgs bundles....

  19. Design and synthesis of DNA four-helix bundles

    Energy Technology Data Exchange (ETDEWEB)

    Rangnekar, Abhijit; Gothelf, Kurt V [Department of Chemistry, Centre for DNA Nanotechnology (CDNA) and Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000 Aarhus C (Denmark); LaBean, Thomas H, E-mail: kvg@chem.au.dk, E-mail: thl@cs.duke.edu [Department of Chemistry, Duke University, Durham, NC 27708 (United States)

    2011-06-10

    The field of DNA nanotechnology has evolved significantly in the past decade. Researchers have succeeded in synthesizing tile-based structures and using them to form periodic lattices in one, two and three dimensions. Origami-based structures have also been used to create nanoscale structures in two and three dimensions. Design and construction of DNA bundles with fixed circumference has added a new dimension to the field. Here we report the design and synthesis of a DNA four-helix bundle. It was found to be extremely rigid and stable. When several such bundles were assembled using appropriate sticky-ends, they formed micrometre-long filaments. However, when creation of two-dimensional sheet-like arrays of the four-helix bundles was attempted, nanoscale rings were observed instead. The exact reason behind the nanoring formation is yet to be ascertained, but it provides an exciting prospect for making programmable circular nanostructures using DNA.

  20. A Discrete Theory of Connections on Principal Bundles

    OpenAIRE

    Leok, M; Marsden, JE; Weinstein, AD

    2017-01-01

    Connections on principal bundles play a fundamental role in expressing the equations of motion for mechanical systems with symmetry in an intrinsic fashion. A discrete theory of connections on principal bundles is constructed by introducing the discrete analogue of the Atiyah sequence, with a connection corresponding to the choice of a splitting of the short exact sequence. Equivalent representations of a discrete connection are considered, and an extension of the pair groupoid composition, t...

  1. On the Geometry of Cotangent Bundles of Lie Groups

    OpenAIRE

    Manga, Bakary

    2015-01-01

    Lie groups of automorphisms of cotangent bundles of Lie groups are completely characterized and interesting results are obtained. We give prominence to the fact that the Lie groups of automorphisms of cotangent bundles of Lie groups are super symmetric Lie groups. In the cases of orthogonal Lie lgebras, semi-simple Lie algebras and compact Lie algebras we recover by simple methods interesting co-homological known results. The Lie algebra of prederivations encompasses the one of derivations as...

  2. CHF prediction in rod bundles using round tube data

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Wallen F.; Veloso, Maria A.F.; Pereira, Cláubia; Costa, Antonella L., E-mail: wallenfds@yahoo.com.br, E-mail: mdora@nuclear.ufmg.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Engenharia Nuclear

    2017-07-01

    The present work concerns the use of 1995 CHF table for uniformly heated round tubes, developed jointly by Canadian and Russian researchers, for the prediction of critical heat fluxes in rod bundles geometries. Comparisons between measured and calculated critical heat fluxes indicate that this table could be applied to rod bundles provided that a suitable correction factor is employed. The tolerance limits associated with the departure from nucleate boiling ratio (DNBR) are evaluated by using statistical analysis. (author)

  3. Page 1 Moduli for bundles over curves - 325 through the ...

    Indian Academy of Sciences (India)

    (B End V, with the reduced structure. Note that C is an open subscheme in C and C is a multicone in G) End V. By the hypothesis of the lemma and assumption Mo = G, for te Twe have an isomorphism (p, Eo- ºr, We can interpret p, as a section of the fiber bundle (e. X ..) (G) with fiber G associated to the G × G. bundle Eo * Č, ...

  4. Mitotic spindle: kinetochore fibers hold on tight to interpolar bundles.

    Science.gov (United States)

    Tolić, Iva M

    2017-07-19

    When a cell starts to divide, it forms a spindle, a micro-machine made of microtubules, which separates the duplicated chromosomes. The attachment of microtubules to chromosomes is mediated by kinetochores, protein complexes on the chromosome. Spindle microtubules can be divided into three major classes: kinetochore microtubules, which form k-fibers ending at the kinetochore; interpolar microtubules, which extend from the opposite sides of the spindle and interact in the middle; and astral microtubules, which extend towards the cell cortex. Recent work in human cells has shown a close relationship between interpolar and kinetochore microtubules, where interpolar bundles are attached laterally to kinetochore fibers almost all along their length, acting as a bridge between sister k-fibers. Most of the interpolar bundles are attached to a pair of sister kinetochore fibers and vice versa. Thus, the spindle is made of modules consisting of a pair of sister kinetochore fibers and a bundle of interpolar microtubules that connects them. These interpolar bundles, termed bridging fibers, balance the forces acting at kinetochores and support the rounded shape of the spindle during metaphase. This review discusses the structure, function, and formation of kinetochore fibers and interpolar bundles, with an emphasis on how they interact. Their connections have an impact on the force balance in the spindle and on chromosome movement during mitosis because the forces in interpolar bundles are transmitted to kinetochore fibers and hence to kinetochores through these connections.

  5. Splitting 3-plane sub-bundles over the product of two real projective spaces

    Directory of Open Access Journals (Sweden)

    Maria Hermínia de Paula Leite Mello

    2003-11-01

    Full Text Available Let α be a real vector bundle of fiber dimension three over the product RP(m×RP(n which splits as a Whitney sum of line bundles. We show that the necessary and sufficient conditions for α to embed as a sub-bundle of a certain family of vector bundles β of fiber dimension m+n is the vanishing of the last three Stiefel-Whitney classes of the virtual bundle0 β−α. Among the target bundles β we consider the tangent bundle.

  6. Human peptide transporters

    DEFF Research Database (Denmark)

    Nielsen, Carsten Uhd; Brodin, Birger; Jørgensen, Flemming Steen

    2002-01-01

    Peptide transporters are epithelial solute carriers. Their functional role has been characterised in the small intestine and proximal tubules, where they are involved in absorption of dietary peptides and peptide reabsorption, respectively. Currently, two peptide transporters, PepT1 and PepT2...... to peptide transporters, as well as their role in drug delivery and in potential future drug design and targeted tissue delivery of peptides and peptidomimetics....

  7. Human Antimicrobial Peptides and Proteins

    Directory of Open Access Journals (Sweden)

    Guangshun Wang

    2014-05-01

    Full Text Available As the key components of innate immunity, human host defense antimicrobial peptides and proteins (AMPs play a critical role in warding off invading microbial pathogens. In addition, AMPs can possess other biological functions such as apoptosis, wound healing, and immune modulation. This article provides an overview on the identification, activity, 3D structure, and mechanism of action of human AMPs selected from the antimicrobial peptide database. Over 100 such peptides have been identified from a variety of tissues and epithelial surfaces, including skin, eyes, ears, mouths, gut, immune, nervous and urinary systems. These peptides vary from 10 to 150 amino acids with a net charge between −3 and +20 and a hydrophobic content below 60%. The sequence diversity enables human AMPs to adopt various 3D structures and to attack pathogens by different mechanisms. While α-defensin HD-6 can self-assemble on the bacterial surface into nanonets to entangle bacteria, both HNP-1 and β-defensin hBD-3 are able to block cell wall biosynthesis by binding to lipid II. Lysozyme is well-characterized to cleave bacterial cell wall polysaccharides but can also kill bacteria by a non-catalytic mechanism. The two hydrophobic domains in the long amphipathic α-helix of human cathelicidin LL-37 lays the basis for binding and disrupting the curved anionic bacterial membrane surfaces by forming pores or via the carpet model. Furthermore, dermcidin may serve as ion channel by forming a long helix-bundle structure. In addition, the C-type lectin RegIIIα can initially recognize bacterial peptidoglycans followed by pore formation in the membrane. Finally, histatin 5 and GAPDH(2-32 can enter microbial cells to exert their effects. It appears that granulysin enters cells and kills intracellular pathogens with the aid of pore-forming perforin. This arsenal of human defense proteins not only keeps us healthy but also inspires the development of a new generation of personalized

  8. A quantitative histopathological study of right bundle branch block complicating acute anteroseptal myocardial infarction.

    OpenAIRE

    Okabe, M; Fukuda, K; Nakashima, Y; Hiroki, T; Arakawa, K; Kikuchi, M

    1991-01-01

    The aim of the present study was to evaluate whether necrosis of the right bundle branch is responsible for development of right bundle branch block in acute myocardial infarction. Twenty patients with acute anteroseptal myocardial infarction were studied--10 with right bundle branch block (group A) and 10 without (group B)--to evaluate by serial sectioning the pathological extent of myocardial infarction surrounding the right bundle branch and also that of right bundle branch necrosis. Myoca...

  9. SCADOP: Phenomenological modeling of dryout in nuclear fuel rod bundles

    Energy Technology Data Exchange (ETDEWEB)

    Dasgupta, Arnab, E-mail: arnie@barc.gov.in; Chandraker, D.K., E-mail: dineshkc@barc.gov.in; Vijayan, P.K., E-mail: vijayanp@barc.gov.in

    2015-11-15

    Highlights: • Phenomenological model for annular flow dryout is presented. • The model evaluates initial entrained fraction using a new methodology. • The history effect in annular flow is predicted and validated. • Rod bundle dryout is predicted using subchannel methodology. • Model is validated against experimental dryout data in tubes and rod bundles. - Abstract: Analysis and prediction of dryout is of important consequence to safety of nuclear fuel clusters of boiling water type of reactors. Traditionally, experimental correlations are used for dryout predictions. Since these correlations are based on operating parameters and do not aim to model the underlying phenomena, there has been a proliferation of the correlations, each catering to some specific bundle geometry under a specific set of operating conditions. Moreover, such experiments are extremely costly. In general, changes in tested bundle geometry for improvement in thermal-hydraulic performance would require re-experimentation. Understanding and modeling the basic processes leading to dryout in flow boiling thus has great incentive. Such a model has the ability to predict dryout in any rod bundle geometry, unlike the operating parameter based correlation approach. Thus more informed experiments can be carried out. A good model can, reduce the number of experiments required during the iterations in bundle design. In this paper, a phenomenological model as indicated above is presented. The model incorporates a new methodology to estimate the Initial Entrained Fraction (IEF), i.e., entrained fraction at the onset of annular flow. The incorporation of this new methodology is important since IEF is often assumed ad-hoc and sometimes also used as a parameter to tune the model predictions to experimental data. It is highlighted that IEF may be low under certain conditions against the general perception of a high IEF due to influence of churn flow. It is shown that the same phenomenological model is

  10. Histones bundle F-actin filaments and affect actin structure.

    Science.gov (United States)

    Blotnick, Edna; Sol, Asaf; Muhlrad, Andras

    2017-01-01

    Histones are small polycationic proteins complexed with DNA located in the cell nucleus. Upon apoptosis they are secreted from the cells and react with extracellular polyanionic compounds. Actin which is a polyanionic protein, is also secreted from necrotic cells and interacts with histones. We showed that both histone mixture (histone type III) and the recombinant H2A histone bundles F-actin, increases the viscosity of the F-actin containing solution and polymerizes G-actin. The histone-actin bundles are relatively insensitive to increase of ionic strength, unlike other polycation, histatin, lysozyme, spermine and LL-37 induced F-actin bundles. The histone-actin bundles dissociate completely only in the presence of 300-400 mM NaCl. DNA, which competes with F-actin for histones, disassembles histone induced actin bundles. DNase1, which depolymerizes F- to G-actin, actively unbundles the H2A histone induced but slightly affects the histone mixture induced actin bundles. Cofilin decreases the amount of F-actin sedimented by low speed centrifugation, increases light scattering and viscosity of F-actin-histone mixture containing solutions and forms star like superstructures by copolymerizing G-actin with H2A histone. The results indicate that histones are tightly attached to F-actin by strong electrostatic and hydrophobic forces. Since both histones and F-actin are present in the sputum of patients with cystic fibrosis, therefore, the formation of the stable histone-actin bundles can contribute to the pathology of this disease by increasing the viscosity of the sputum. The actin-histone interaction in the nucleus might affect gene expression.

  11. Histones bundle F-actin filaments and affect actin structure.

    Directory of Open Access Journals (Sweden)

    Edna Blotnick

    Full Text Available Histones are small polycationic proteins complexed with DNA located in the cell nucleus. Upon apoptosis they are secreted from the cells and react with extracellular polyanionic compounds. Actin which is a polyanionic protein, is also secreted from necrotic cells and interacts with histones. We showed that both histone mixture (histone type III and the recombinant H2A histone bundles F-actin, increases the viscosity of the F-actin containing solution and polymerizes G-actin. The histone-actin bundles are relatively insensitive to increase of ionic strength, unlike other polycation, histatin, lysozyme, spermine and LL-37 induced F-actin bundles. The histone-actin bundles dissociate completely only in the presence of 300-400 mM NaCl. DNA, which competes with F-actin for histones, disassembles histone induced actin bundles. DNase1, which depolymerizes F- to G-actin, actively unbundles the H2A histone induced but slightly affects the histone mixture induced actin bundles. Cofilin decreases the amount of F-actin sedimented by low speed centrifugation, increases light scattering and viscosity of F-actin-histone mixture containing solutions and forms star like superstructures by copolymerizing G-actin with H2A histone. The results indicate that histones are tightly attached to F-actin by strong electrostatic and hydrophobic forces. Since both histones and F-actin are present in the sputum of patients with cystic fibrosis, therefore, the formation of the stable histone-actin bundles can contribute to the pathology of this disease by increasing the viscosity of the sputum. The actin-histone interaction in the nucleus might affect gene expression.

  12. Kinetically controlled transition from disordered aggregates to ordered lattices of a computationally designed peptide sequence.

    Science.gov (United States)

    Tian, Yu; Zhang, Huixi; Kiick, Kristi; Saven, Jeffrey; Pochan, Darrin

    Peptides with well-defined secondary-structures have the ability to exhibit specific, local shapes, which enables the design of complex nanostructures through intermolecular assembly. Our computationally designed coiled-coil homotetrameric peptide building block can self-assemble into 2-D nanomaterial lattices with predetermined symmetries by control of the coiled-coil bundle exterior amino acid residues. And the assemblies can be controlled kinetically. Firstly, the solution pH influences the assembly by affecting the external charged state of peptide bundles which can lead the bundles to be either repulsive or attractive to each other. At room temperature when peptides are under the least charged pH conditions, disordered aggregates are formed that slowly transformed into the desired 2-D lattice structures over long periods of time (weeks). Around neutral pH, even subtle charge differences that come from small pH changes can have an influence on the thickness of afterwards formed plates. Secondly, the solution temperature can largely eliminate the formation of disordered aggregates and accelerate the assembling of matured, desired nanomaterial plates by providing extra energy for the organization process of assembly building blocks. The ability to control the assembly process kinetically makes our peptide plate assemblies very promising templates for further applications to develop inorganic-organic hybrid materials. Funding acknowledged from NSF DMREF program under awards DMR-1234161 and DMR-1235084.

  13. Side chain packing below the fusion peptide strongly modulates triggering of the Hendra virus F protein.

    Science.gov (United States)

    Smith, Everett Clinton; Dutch, Rebecca Ellis

    2010-10-01

    Triggering of the Hendra virus fusion (F) protein is required to initiate the conformational changes which drive membrane fusion, but the factors which control triggering remain poorly understood. Mutation of a histidine predicted to lie near the fusion peptide to alanine greatly reduced fusion despite wild-type cell surface expression levels, while asparagine substitution resulted in a moderate restoration in fusion levels. Slowed kinetics of six-helix bundle formation, as judged by sensitivity to heptad repeat B-derived peptides, was observed for all H372 mutants. These data suggest that side chain packing beneath the fusion peptide is an important regulator of Hendra virus F triggering.

  14. An in vitro biomechanical comparison of anterior cruciate ligament reconstruction: single bundle versus anatomical double bundle techniques

    Directory of Open Access Journals (Sweden)

    Sandra Umeda Sasaki

    2008-01-01

    Full Text Available INTRODUCTION: Anterior cruciate ligament ruptures are frequent, especially in sports. Surgical reconstruction with autologous grafts is widely employed in the international literature. Controversies remain with respect to technique variations as continuous research for improvement takes place. One of these variations is the anatomical double bundle technique, which is performed instead of the conventional single bundle technique. More recently, there has been a tendency towards positioning the two bundles through double bone tunnels in the femur and tibia (anatomical reconstruction. OBJECTIVES: To compare, through biomechanical tests, the practice of anatomical double bundle anterior cruciate ligament reconstruction with a patellar graft to conventional single bundle reconstruction with the same amount of patellar graft in a paired experimental cadaver study. METHODS: Nine pairs of male cadaver knees ranging in age from 44 to 63 years were randomized into two groups: group A (single bundle and group B (anatomical reconstruction. Each knee was biomechanically tested under three conditions: intact anterior cruciate ligament, reconstructed anterior cruciate ligament, and injured anterior cruciate ligament. Maximum anterior dislocation, rigidity, and passive internal tibia rotation were recorded with knees submitted to a 100 N horizontal anterior dislocation force applied to the tibia with the knees at 30, 60 and 90 degrees of flexion. RESULTS: There were no differences between the two techniques for any of the measurements by ANOVA tests. CONCLUSION: The technique of anatomical double bundle reconstruction of the anterior cruciate ligament with bone-patellar tendon-bone graft has a similar biomechanical behavior with regard to anterior tibial dislocation, rigidity, and passive internal tibial rotation.

  15. Effects of different initial bundle tensioning strategies on the outcome of double-bundle ACL reconstruction: a cohort study

    Directory of Open Access Journals (Sweden)

    Muneta Takeshi

    2011-07-01

    Full Text Available Abstract Background This study was performed to investigate the effects of different strategies and initial tension applied to each one of the bundles, antero-medial (AM and postero-lateral (PL, on clinical outcome in double bundle (DB ACL reconstruction. Methods One hundred fifty-one primary unilateral DB ACL reconstructions performed by a single surgeon from 1994 through 2002 were included in the study with a follow-up of at least 24 months. They were divided in the following 3 groups: Group I - Higher initial tension applied manually in the AM bundle compared to PL. II - Higher tension applied in the PL bundle compared to AM. III - The 2 bundles were attempted to be equally tensioned. All fixations were performed in 30 degrees of flexion. Group I = 59 patients, group II = 53 patients and group III = 39 patients. The groups had no statistical differences concerning demographic distribution. Clinical outcome was retrospectively evaluated by use of knee range of motion, manual knee laxity tests, KT-1000, Lysholm knee scale, subjective recovery scale and sports performance recovery scale. The differences of data were analyzed among the three groups. Results Group I showed a significant extension deficit compared with groups II and III. ANOVA revealed a significant difference of anterior laxity measured by the KT-1000 (average KT difference of 2.1, 2.1 and 1.2 mm in Group I, II and III, respectively. A statistical difference was found among the three groups regarding subjective and sports performance recovery scales with Group II showing higher scores in recovery than Group I. Conclusions The current clinical study does not recommend manual maximum of initial tension applied to the anteromedial or posterolateral bundles with graft tension imbalance at 30 degrees of flexion in double-bundle ACL reconstruction to achieve a better clinical outcome.

  16. Antimicrobial peptides in action

    NARCIS (Netherlands)

    Leontiadou, Hari; Mark, Alan E.; Marrink, Siewert J.

    2006-01-01

    Molecular dynamics simulations of the magainin MG-H2 peptide interacting with a model phospholipid membrane have been used to investigate the mechanism by which antimicrobial peptides act. Multiple copies of the peptide were randomly placed in solution close to the membrane. The peptide readily

  17. The 2-Hilbert space of a prequantum bundle gerbe

    Science.gov (United States)

    Bunk, Severin; Sämann, Christian; Szabo, Richard J.

    We construct a prequantum 2-Hilbert space for any line bundle gerbe whose Dixmier-Douady class is torsion. Analogously to usual prequantization, this 2-Hilbert space has the category of sections of the line bundle gerbe as its underlying 2-vector space. These sections are obtained as certain morphism categories in Waldorf’s version of the 2-category of line bundle gerbes. We show that these morphism categories carry a monoidal structure under which they are semisimple and abelian. We introduce a dual functor on the sections, which yields a closed structure on the morphisms between bundle gerbes and turns the category of sections into a 2-Hilbert space. We discuss how these 2-Hilbert spaces fit various expectations from higher prequantization. We then extend the transgression functor to the full 2-category of bundle gerbes and demonstrate its compatibility with the additional structures introduced. We discuss various aspects of Kostant-Souriau prequantization in this setting, including its dimensional reduction to ordinary prequantization.

  18. Improvements to Wire Bundle Thermal Modeling for Ampacity Determination

    Science.gov (United States)

    Rickman, Steve L.; Iannello, Christopher J.; Shariff, Khadijah

    2017-01-01

    Determining current carrying capacity (ampacity) of wire bundles in aerospace vehicles is critical not only to safety but also to efficient design. Published standards provide guidance on determining wire bundle ampacity but offer little flexibility for configurations where wire bundles of mixed gauges and currents are employed with varying external insulation jacket surface properties. Thermal modeling has been employed in an attempt to develop techniques to assist in ampacity determination for these complex configurations. Previous developments allowed analysis of wire bundle configurations but was constrained to configurations comprised of less than 50 elements. Additionally, for vacuum analyses, configurations with very low emittance external jackets suffered from numerical instability in the solution. A new thermal modeler is presented allowing for larger configurations and is not constrained for low bundle infrared emissivity calculations. Formulation of key internal radiation and interface conductance parameters is discussed including the effects of temperature and air pressure on wire to wire thermal conductance. Test cases comparing model-predicted ampacity and that calculated from standards documents are presented.

  19. Anatomy of an Oligourea Six-Helix Bundle.

    Science.gov (United States)

    Lombardo, Caterina M; Collie, Gavin W; Pulka-Ziach, Karolina; Rosu, Frederic; Gabelica, Valerie; Mackereth, Cameron D; Guichard, Gilles

    2016-08-24

    Non-natural synthetic oligomers that adopt well-defined secondary structures (i.e., foldamers) represent appealing components for the fabrication of bioinspired self-assembled architectures at the nanometer scale. Recently, peptidomimetic N,N'-linked oligourea helices have been designed de novo with the ability to fold into discrete helix bundles in aqueous conditions. In order to gain better insight into the determinants of oligourea helix bundle formation, we have investigated the sequence-to-structure relationship of an 11-mer oligourea previously shown to assemble into a six-helix bundle. Using circular dichroism, NMR spectroscopy, native mass-spectrometry and X-ray crystallography, we studied how bundle formation was affected by systematic replacement of the hydrophobic surface of the oligourea helix with either polar or different hydrophobic side chains. The molecular information gathered here has revealed several key requirements for foldamer bundle formation in aqueous conditions, and provides valuable insight toward the development of foldamer quaternary assemblies with improved (bio)physical properties and divergent topologies.

  20. Ecosystem service bundles for analyzing tradeoffs in diverse landscapes

    Science.gov (United States)

    Raudsepp-Hearne, C.; Peterson, G. D.; Bennett, E. M.

    2010-01-01

    A key challenge of ecosystem management is determining how to manage multiple ecosystem services across landscapes. Enhancing important provisioning ecosystem services, such as food and timber, often leads to tradeoffs between regulating and cultural ecosystem services, such as nutrient cycling, flood protection, and tourism. We developed a framework for analyzing the provision of multiple ecosystem services across landscapes and present an empirical demonstration of ecosystem service bundles, sets of services that appear together repeatedly. Ecosystem service bundles were identified by analyzing the spatial patterns of 12 ecosystem services in a mixed-use landscape consisting of 137 municipalities in Quebec, Canada. We identified six types of ecosystem service bundles and were able to link these bundles to areas on the landscape characterized by distinct social–ecological dynamics. Our results show landscape-scale tradeoffs between provisioning and almost all regulating and cultural ecosystem services, and they show that a greater diversity of ecosystem services is positively correlated with the provision of regulating ecosystem services. Ecosystem service-bundle analysis can identify areas on a landscape where ecosystem management has produced exceptionally desirable or undesirable sets of ecosystem services. PMID:20194739

  1. Syntheses of Nanostructure Bundles Based on Semiconducting Metal Silicides

    Science.gov (United States)

    Li, Wen; Ishikawa, Daisuke; Tatsuoka, Hirokazu

    2013-08-01

    A variety of nanostructure bundles and arrays based on semiconducting metal silicides have been synthesized using abundant and non-toxic starting materials. Three types of fabrication techniques of the nanostructure bundles or arrays, including direct growth, template synthesis using natural nanostructured materials and template synthesis using artificially fabricated nanostructured materials are demonstrated. CrSi2 nanowire bundles were directly grown by the exposure of Si substrates to CrCl2 vapor at atmospheric pressure. A hexagonal MoSi2 nanosheet, Mg2Si/MgO composite nanowire and Mg2Si nanowire bundles and MnSi1.7 nanowire array were synthesized using a MoS2 layered material, a SiOx nanofiber bundle, a Si nanowire array, and a Si nanowire array as the templates, respectively. Additionally, the fabrication phenomenon and structural properties of the nanostructured semiconducting metal silicides were investigated. These reactions provided the low-cost and controllable synthetic techniques to synthesize large scale and one-dimensional semiconducting metal silicides for thermoelectric applications.

  2. A prospective comparative study of clinical and functional outcomes between anatomic double bundle and single bundle hamstring grafts for arthroscopic anterior cruciate ligament reconstruction.

    Science.gov (United States)

    Morey, Vivek M; Nag, Hira Lal; Chowdhury, Buddhadev; Sankineani, Sukesh Rao; Naranje, Sameer M

    2015-09-01

    Despite a number of studies comparing postoperative stability and function after anatomic single bundle and double bundle anterior cruciate ligament reconstruction, it remains unclear whether double bundle reconstruction has better functional outcome than single bundle anterior cruciate ligament reconstruction. To compare the subjective functional outcome as well as clinical stability in patients treated with either anatomic single bundle or anatomic double bundle anterior cruciate ligament (ACL) reconstruction. We hypothesized that there would be no difference in the postoperative functional outcome and clinical stability between anatomical double bundle anterior cruciate ligament reconstructions when compared to single bundle anterior cruciate ligament reconstructions. We prospectively followed 40 patients out of which, 20 patients were operated for anatomic single bundle ACL reconstruction and other 20 patients underwent anatomic double bundle ACL reconstruction. Patient evaluation using the laxity tests and outcome scales was done preoperatively and at 12, 24 and 48 months after the surgery. Clinical stability was assessed by Lachman test, Pivot shift test and Delhi active test. Functional outcome was assessed by International Knee Documentation Committee (IKDC), Lysholm and Modified Cincinnati scores. Patients in both groups were evaluated at regular intervals for a minimum period of 48 months (mean 51 months, range 48-56 months). For all subjective scores, double bundle group patients reported statistically significant higher scores compared to single bundle group patients. Graded stability results of the Lachman, and Pivot shift tests were significantly higher in the anatomically reconstructed double bundle patient group. We suggest that functional outcome and clinical stability may be better with anatomical double bundle anterior cruciate ligament reconstruction as compared to anatomical single bundle anterior cruciate ligament reconstruction. Copyright

  3. Different effects of implanting vascular bundles and sensory nerve tracts on the expression of neuropeptide receptors in tissue-engineered bone in vivo

    Energy Technology Data Exchange (ETDEWEB)

    Chen Siyuan; Qin Junjun; Wang Le; Mu Tianwang; Jin Dan; Jiang Shan; Zhao Peiran [Department of Orthopaedic and Trauma, Nanfang Hospital, Southern Medical University, Guangzhou 510515 (China); Pei Guoxian, E-mail: easonfaye_2001@qq.co [Department of Orthopaedic Surgery, Xijing Hospital, The Fourth Military Medical University, Xi' an 710032 (China)

    2010-10-01

    We investigated whether implantation of vascular bundles or sensory nerves affected the expression of calcitonin gene-related peptide type I receptor (CGRP1R) and neuropeptide Y1 receptor (NPY1R) in tissue-engineered bone. We implanted osteogenically induced bone marrow mesenchymal stem cells (BMSCs) with {beta}-tricalcium phosphate ({beta}-TCP) as the scaffold material either with sensory nerve tracts (group I, n = 18), vascular bundles (group II, n = 18) or alone (group III, n = 18) to repair a 1.2 cm femur defect in the rabbit. Better osteogenesis was observed by x-ray and histology in groups I and II than in group III at 4, 8 and 12 weeks. Within the new bone, the mRNA levels of the two neuropeptide receptors determined by real-time PCR increased through week 8, and then gradually decreased (P < 0.05). Expression of the neuropeptide receptors determined by immunohistochemistry was lowest at 4 weeks (P < 0.05) and was higher in group II than in group I (P < 0.05). Expression was significantly higher in groups I and II than in group III at all time points. We conclude that implanting vascular bundles into tissue-engineered bone can significantly improve the early expression of CGRP1R and NPY1R. In contrast, implantation of sensory nerves did not show the same dramatic effect as implantation of vascular bundles.

  4. Collagen mimetic peptide discs promote assembly of a broad range of natural protein fibers through hydrophobic interactions.

    Science.gov (United States)

    McGuinness, Kenneth; Nanda, Vikas

    2017-07-19

    Collagen mimetic peptides that alone formed two-dimensional nanoscale discs driven by hydrophobic interactions were shown in electron microscopy studies to also co-assemble with natural fibrous proteins to produce discs-on-a-string (DoS) nanostructures. In most cases, peptide discs also facilitated bundling of the protein fibers. This provides insight into how synthetic and natural proteins may be combined to develop multicomponent, multi-dimensional architectures at the nanoscale.

  5. Single-Phase Bundle Flows Including Macroscopic Turbulence Model

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seung Jun; Yoon, Han Young [KAERI, Daejeon (Korea, Republic of); Yoon, Seok Jong; Cho, Hyoung Kyu [Seoul National University, Seoul (Korea, Republic of)

    2016-05-15

    To deal with various thermal hydraulic phenomena due to rapid change of fluid properties when an accident happens, securing mechanistic approaches as much as possible may reduce the uncertainty arising from improper applications of the experimental models. In this study, the turbulence mixing model, which is well defined in the subchannel analysis code such as VIPRE, COBRA, and MATRA by experiments, is replaced by a macroscopic k-e turbulence model, which represents the aspect of mathematical derivation. The performance of CUPID with macroscopic turbulence model is validated against several bundle experiments: CNEN 4x4 and PNL 7x7 rod bundle tests. In this study, the macroscopic k-e model has been validated for the application to subchannel analysis. It has been implemented in the CUPID code and validated against CNEN 4x4 and PNL 7x7 rod bundle tests. The results showed that the macroscopic k-e turbulence model can estimate the experiments properly.

  6. Symposium on Singularities, Representation of Algebras, and Vector Bundles

    CERN Document Server

    Trautmann, Günther

    1987-01-01

    It is well known that there are close relations between classes of singularities and representation theory via the McKay correspondence and between representation theory and vector bundles on projective spaces via the Bernstein-Gelfand-Gelfand construction. These relations however cannot be considered to be either completely understood or fully exploited. These proceedings document recent developments in the area. The questions and methods of representation theory have applications to singularities and to vector bundles. Representation theory itself, which had primarily developed its methods for Artinian algebras, starts to investigate algebras of higher dimension partly because of these applications. Future research in representation theory may be spurred by the classification of singularities and the highly developed theory of moduli for vector bundles. The volume contains 3 survey articles on the 3 main topics mentioned, stressing their interrelationships, as well as original research papers.

  7. Narrow muon bundles from muon pair production in rock

    CERN Document Server

    Kudryavtsev, V A; Spooner, N J C

    1999-01-01

    We revise the process of muon pair production by high-energy muons in rock using the recently published cross-section. The three- dimensional Monte Carlo code MUSIC has been used to obtain the characteristics of the muon bundles initiated via this process. We have compared them with those of conventional muon bundles initiated in the atmosphere and shown that large underground detectors, capable of collecting hundreds of thousands of multiple muon events, can discriminate statistically muon induced bundles from conventional ones. However, we find that the enhancement of the measured muon decoherence function over that predicted at small distances, recently reported by the MACRO experiment, cannot be explained by the effect of muon pair production alone, unless its cross-section is underestimated by a factor of 3. (20 refs).

  8. Product bundling as a customer loyalty strategy; Kundenbindung durch Produktbuendel

    Energy Technology Data Exchange (ETDEWEB)

    Wolf, H.G. [Arthur Andersen Business Consulting GmbH, Duesseldorf (Germany)

    2000-12-01

    In the deregulated market in electricity, all marketers and energy-related service providers are competing not only for new customers, but also for customer loyalty. The article sets out concepts and strategies developed by a business consulting firm, for maintaing or enhancing customer loyalty in the end-use market segment, focusing on customized product bundling. A four-tier approach for product bundle development and implementation is discussed. (orig./CB) [German] Fuer Energieversorger und -dienstleister ergibt sich neben der Neukundengewinnung der strategische Zwang zur Bindung bestehender Kunden. An praktischen Ansaetzen fuer Privatkunden stehen neben Value-Added-Services und Incentives (Kundenclub, -karte) nicht zuletzt Produktbuendel (Bundles) zur Verfuegung. Zur erfolgreichen Entwicklung und Implementierung von Produktbuendeln wird ein vierphasiges Vorgehensmodell erlaeutert. (orig./CB)

  9. Transient Left Bundle Branch Block due to Severe Hyperkalemia.

    Science.gov (United States)

    Kumar, Kishore; Biyyam, Madhavi; Singh, Amandeep; Bajantri, Bharat; Tariq, Hassan; Nayudu, Suresh Kumar; Chilimuri, Sridhar

    2017-04-01

    Hyperkalemia is a potentially life-threatening electrolyte imbalance that can lead to sudden death from cardiac arrhythmias and asystole. We present a case of transient left bundle branch block pattern on an electrocardiogram (ECG) secondary to hyperkalemia in a patient with history of end-stage renal disease. A 52-year-old man presented to the emergency room (ER) with chief complaints of weakness and lethargy after missing his regularly scheduled session of hemodialysis. A 12-lead ECG in the ER showed sinus tachycardia at 118 beats/min, wide QRS complexes, peaked T waves and left bundle branch block-like pattern. The initial basic metabolic panel revealed a serum potassium level of 8.8 mEq/L. Subsequently, the patient underwent emergent hemodialysis. Serum chemistry after hemodialysis showed improvement in serum potassium to 4.3 mEq/L. Repeat ECG performed after correcting potassium showed dissolution of left bundle branch block finding.

  10. Measurement of secondary flow vortices on a rod bundle

    Energy Technology Data Exchange (ETDEWEB)

    Vonka, V.

    1988-02-01

    Secondary flow vortices in infinite rod bundles have been predicted by a number of theoretical analyses. Nevertheless experimental verification was difficult, since the magnitude of the secondary velocities appeared to be less than the accuracy of the experimental techniques used. Only indications of the maximum velocity magnitude have been available but no report on successful direct measurement is known to the author. At ECN, laser Doppler velocimetry is successfully used for measurement of secondary flow vortices in two regular subchannels of a triangularly arranged bare rod bundle with pitch-to-diameter ratio P/D-1.3 under the Reynolds number conditions 60,000 and 175,000. One single secondary vortex, having the average tangential velocity slightly less than 0.1% of the mean bulk velocity, is resolved per minimum symmetry sector of the bundle geometry. Ensemble averages are made to obtain quantitative description of the vortex and to form a data base for comparison with calculations.

  11. Gradient Bundle Analysis: A Full Topological Approach to Chemical Bonding

    CERN Document Server

    Morgenstern, Amanda

    2016-01-01

    The "chemical bond" is a central concept in molecular sciences, but there is no consensus as to what a bond actually is. Therefore, a variety of bonding models have been developed, each defining the structure of molecules in a different manner with the goal of explaining and predicting chemical properties. This thesis describes the initial development of gradient bundle analysis (GBA), a chemical bonding model that creates a high resolution picture of chemical interactions within the charge density framework. GBA is based on concepts from the quantum theory of atoms in molecules (QTAIM), but uses a more complete picture of the topology and geometry of the electron charge density to understand and predict bonding interactions. Gradient bundles are defined as volumes bounded by zero-flux surfaces (ZFSs) in the gradient of the charge density with well-defined energies. The structure of gradient bundles provides an avenue for detecting the locations of valence electrons, which correspond to reactive regions in a ...

  12. Failure of a MEA reclaimer tube bundle due to corrosion

    Energy Technology Data Exchange (ETDEWEB)

    Shaban, H.; Abdo, M.S.E.; Lal, D.P.

    1988-08-01

    The removal of sulphur compounds from natural gas used in ammonia production is carried out by scrubbing with monoethanol amine (MEA). To avoid build up of corrosion and degradation products, a portion of the circulating MEA solution is passed through a reclaimer. This is essentially a kettle-type reboiler with a tube bundle made of 316L stainless steel. Occasional failures of the tube bundle due to pitting corrosion have been reported. It is suggested that the excessive pitting corrosion observed on the upper rows of the tube bundle could be partly due to high steam temperature but mainly due to the liquid level falling below the tubes leaving an accumulation of corrosive degradation products on the exposed surfaces, normally these corrosive products remain diluted in the MEA solution and cause little corrosion of the covered tubes. Their concentration on the dry upper layers of the hot metal tubes, however, leads to excessive corrosion. (U.K.).

  13. The concept of double bundle ACL simulation with a single bundle patellar tendon graft. A cadaveric feasibility study.

    Science.gov (United States)

    Jacobi, Matthias; Magnussen, Robert A; Villa, Vincent; Demey, Guillaume; Neyret, Philippe

    2012-06-07

    There is significant interest in the restoration of the double-bundle anatomy of the native ACL when performing ACL reconstruction. Possible techniques include those utilizing two separate grafts with independent tunnels and those that attempt to mimic this anatomy with a single graft and fewer tunnels. Many of the latter techniques require specific instrumentation and are technically challenging. We demonstrate that the double-bundle anatomy of the native ACL can theoretically be mimicked by a single-bundle reconstruction. We performed single bundle ACL reconstruction with a bone-patellar tendon-bone (BTB) graft in two cadaveric knees. Both grafts were placed to mimic the native ACL footprints - one reconstruction was performed with rectangular bone blocks and oval tunnels and one was performed utilizing a standard BTB graft and round tunnels. Qualitative assessment of graft behavior was made as the knees were taken through a range of motion. The ACL graft was able to qualitatively mimic the behavior of the native ACL in both knees provided the bone blocks were correctly orientated. ACL reconstruction with a single BTB graft can qualitatively mimic the behavior of the two bundles of the native ACL. The key to ensuring this behavior was noted to be appropriate orientation of the graft in the tunnels. Quantitative biomechanical investigations are necessary to evaluate the impact of graft orientation on function.

  14. The concept of double bundle ACL simulation with a single bundle patellar tendon graft. A cadaveric feasibility study

    Directory of Open Access Journals (Sweden)

    Jacobi Matthias

    2012-06-01

    Full Text Available Abstract Background There is significant interest in the restoration of the double-bundle anatomy of the native ACL when performing ACL reconstruction. Possible techniques include those utilizing two separate grafts with independent tunnels and those that attempt to mimic this anatomy with a single graft and fewer tunnels. Many of the latter techniques require specific instrumentation and are technically challenging. We demonstrate that the double-bundle anatomy of the native ACL can theoretically be mimicked by a single-bundle reconstruction. Methods We performed single bundle ACL reconstruction with a bone-patellar tendon-bone (BTB graft in two cadaveric knees. Both grafts were placed to mimic the native ACL footprints – one reconstruction was performed with rectangular bone blocks and oval tunnels and one was performed utilizing a standard BTB graft and round tunnels. Qualitative assessment of graft behavior was made as the knees were taken through a range of motion. Results The ACL graft was able to qualitatively mimic the behavior of the native ACL in both knees provided the bone blocks were correctly orientated. Conclusions ACL reconstruction with a single BTB graft can qualitatively mimic the behavior of the two bundles of the native ACL. The key to ensuring this behavior was noted to be appropriate orientation of the graft in the tunnels. Quantitative biomechanical investigations are necessary to evaluate the impact of graft orientation on function.

  15. Mechanical Stresses and Forces in Stereocilia Bundles of Inner and Outer Hair Cells

    Science.gov (United States)

    Mueller, R.; Maier, H.; Boehnke, F.; Arnold, W.

    2003-02-01

    The precise mechanism of mechanoelectrical transduction in stereocilia bundles is not known. It is very difficult to measure the extremely small stresses, which occur at the stereocilia bundles. Therefore we developed 3-D finite element models of stereocilia bundles (guinea pig) to obtain quantitative results. The stereocilia bundles of the outer hair cells show a characteristic W-form. Therefore, it is interesting to compare the mechanical behavior of the stereocilia bundle of an outer hair cell with that of an inner hair cell with its linear arrangement. Our analysis provides estimates of forces and stresses on the transducer channels of mammalian hair bundles, although the model does not include active mechanisms yet.

  16. The Analysis of SBWR Critical Power Bundle Using Cobrag Code

    Directory of Open Access Journals (Sweden)

    Yohannes Sardjono

    2013-03-01

    Full Text Available The coolant mechanism of SBWR is similar with the Dodewaard Nuclear Power Plant (NPP in the Netherlands that first went critical in 1968. The similarity of both NPP is cooled by natural convection system. These coolant concept is very related with same parameters on fuel bundle design especially fuel bundle length, core pressure drop and core flow rate as well as critical power bundle. The analysis was carried out by using COBRAG computer code. COBRAG computer code is GE Company proprietary. Basically COBRAG computer code is a tool to solve compressible three-dimensional, two fluid, three field equations for two phase flow. The three fields are the vapor field, the continuous liquid field, and the liquid drop field. This code has been applied to analyses model flow and heat transfer within the reactor core. This volume describes the finitevolume equations and the numerical solution methods used to solve these equations. This analysis of same parameters has been done i.e.; inlet sub cooling 20 BTU/lbm and 40 BTU/lbm, 1000 psi pressure and R-factor is 1.038, mass flux are 0.5 Mlb/hr.ft2, 0.75 Mlb/hr.ft2, 1.00 Mlb/hr.ft2 and 1.25 Mlb/hr.ft2. Those conditions based on history operation of some type of the cell fuel bundle line at GE Nuclear Energy. According to the results, it can be concluded that SBWR critical power bundle is 10.5 % less than current BWR critical power bundle with length reduction of 12 ft to 9 ft.

  17. Learning Bundled Care Opportunities from Electronic Medical Records.

    Science.gov (United States)

    Chen, You; Kho, Abel N; Liebovitz, David; Ivory, Catherine; Osmundson, Sarah; Bian, Jiang; Malin, Bradley A

    2017-11-22

    The traditional fee-for-service approach to healthcare can lead to the management of a patient's conditions in a siloed manner, inducing various negative consequences. It has been recognized that a bundled approach to healthcare - one that manages a collection of health conditions together - may enable greater efficacy and cost savings. However, it is not always evident which sets of conditions should be managed in a bundled manner. In this study, we investigate if a data-driven approach can automatically learn potential bundles. We designed a framework to infer health condition collections (HCCs) based on the similarity of their clinical workflows, according to electronic medical record (EMR) utilization. We evaluated the framework with data from over 16,500 inpatient stays from Northwestern Memorial Hospital in Chicago, Illinois. The plausibility of the inferred HCCs for bundled care was assessed through an online survey of a panel of five experts, whose responses were analyzed via an analysis of variance (ANOVA) at a 95% confidence level. We further assessed the face validity of the HCCs using evidence in the published literature. The framework inferred four HCCs, indicative of 1) fetal abnormalities, 2) late pregnancies, 3) prostate problems, and 4) chronic diseases, with congestive heart failure featuring prominently. Each HCC was substantiated with evidence in the literature and was deemed plausible for bundled care by the experts at a statistically significant level. The findings suggest that an automated EMR data-driven framework conducted can provide a basis for discovering bundled care opportunities. Still, translating such findings into actual care management will require further refinement, implementation, and evaluation. Copyright © 2017. Published by Elsevier Inc.

  18. Fast bundle algorithm for multiple-instance learning.

    Science.gov (United States)

    Bergeron, Charles; Moore, Gregory; Zaretzki, Jed; Breneman, Curt M; Bennett, Kristin P

    2012-06-01

    We present a bundle algorithm for multiple-instance classification and ranking. These frameworks yield improved models on many problems possessing special structure. Multiple-instance loss functions are typically nonsmooth and nonconvex, and current algorithms convert these to smooth nonconvex optimization problems that are solved iteratively. Inspired by the latest linear-time subgradient-based methods for support vector machines, we optimize the objective directly using a nonconvex bundle method. Computational results show this method is linearly scalable, while not sacrificing generalization accuracy, permitting modeling on new and larger data sets in computational chemistry and other applications. This new implementation facilitates modeling with kernels.

  19. Cellulosic Fibers: Effect of Processing on Fiber Bundle Strength

    DEFF Research Database (Denmark)

    Thygesen, Anders; Madsen, Bo; Thomsen, Anne Belinda

    2011-01-01

    A range of differently processed cellulosic fibers from flax and hemp plants were investigated to study the relation between processing of cellulosic fibers and fiber bundle strength. The studied processing methods are applied for yarn production and include retting, scutching, carding, and cotto......A range of differently processed cellulosic fibers from flax and hemp plants were investigated to study the relation between processing of cellulosic fibers and fiber bundle strength. The studied processing methods are applied for yarn production and include retting, scutching, carding...

  20. On a Lie Algebraic Characterization of Vector Bundles

    Directory of Open Access Journals (Sweden)

    Pierre B.A. Lecomte

    2012-01-01

    Full Text Available We prove that a vector bundle π: E→M is characterized by the Lie algebra generated by all differential operators on E which are eigenvectors of the Lie derivative in the direction of the Euler vector field. Our result is of Pursell-Shanks type but it is remarkable in the sense that it is the whole fibration that is characterized here. The proof relies on a theorem of [Lecomte P., J. Math. Pures Appl. (9 60 (1981, 229-239] and inherits the same hypotheses. In particular, our characterization holds only for vector bundles of rank greater than 1.

  1. EXTERNAL VERIFICATION OF THE BUNDLE ADJUSTMENT IN PHOTOGRAMMETRIC SOFTWARE USING THE DAMPED BUNDLE ADJUSTMENT TOOLBOX

    Directory of Open Access Journals (Sweden)

    N. Börlin

    2016-06-01

    Full Text Available The aim of this paper is to investigate whether the Matlab-based Damped Bundle Adjustment Toolbox (DBAT can be used to provide independent verification of the BA computation of two popular software—PhotoModeler (PM and PhotoScan (PS. For frame camera data sets with lens distortion, DBAT is able to reprocess and replicate subsets of PM results with high accuracy. For lens-distortion-free data sets, DBAT can furthermore provide comparative results between PM and PS. Data sets for the discussed projects are available from the authors. The use of an external verification tool such as DBAT will enable users to get an independent verification of the computations of their software. In addition, DBAT can provide computation of quality parameters such as estimated standard deviations, correlation between parameters, etc., something that should be part of best practice for any photogrammetric software. Finally, as the code is free and open-source, users can add computations of their own.

  2. Innovative Defense Acquisition Concept Deployer Equipment Bundle (DEB)

    Science.gov (United States)

    2017-06-01

    METHODOLOGY This project reviewed a substantial amount of literature , to include applicable concept plans, memorandums, cost benefit analyses, organizational...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT INNOVATIVE DEFENSE ACQUISITION CONCEPT DEPLOYER...ACQUISITION CONCEPT DEPLOYER EQUIPMENT BUNDLE (DEB) 5. FUNDING NUMBERS 6. AUTHOR(S) Frederic Albesa, Isaac J. Ortman, and Stephen F. Kirouac 7

  3. Temperature response of bundle-sheath conductance in maize leaves

    NARCIS (Netherlands)

    Yin, Xinyou; Putten, Van Der Peter E.L.; Struik, Paul C.; Driever, Steven M.

    2016-01-01

    A small bundle-sheath conductance (g bs) is essential for the C4 CO2-concentrating mechanism to suppress photorespiration effectively. To predict the productivity of C4 crops accurately under global warming, it is necessary to examine whether and how g

  4. Quillen bundle and geometric prequantization of non-abelian ...

    Indian Academy of Sciences (India)

    E-mail: rkmn@mri.ernet.in; rukmini.dey@gmail.com; smr@bose.res.in. MS received 7 September 2010; revised 23 November 2010. Abstract. In this paper we prequantize the moduli space of non-abelian vortices. We explicitly calculate the symplectic form arising from L2 metric and we construct a prequantum line bundle ...

  5. Multicell slug flow heat transfer analysis of finite LMFBR bundles

    Energy Technology Data Exchange (ETDEWEB)

    Yeung, M.K.; Wolf, L.

    1978-12-01

    An analytical two-dimensional, multi-region, multi-cell technique has been developed for the thermal analysis of LMFBR rod bundles. Local temperature fields of various unit cells were obtained for 7, 19, and 37-rod bundles of different geometries and power distributions. The validity of the technique has been verified by its excellent agreement with the THTB calculational result. By comparing the calculated fully-developed circumferential clad temperature distribution with those of the experimental measurements, an axial correction factor has been derived to account for the entrance effect for practical considerations. Moreover, the knowledge of the local temperature field of the rod bundle leads to the determination of the effective mixing lengths L/sub ij/ for adjacent subchannels of various geometries. It was shown that the implementation of the accurately determined L/sub ij/ into COBRA-IIIC calculations has fairly significant effects on intersubchannel mixing. In addition, a scheme has been proposed to couple the 2-D distributed and lumped parameter calculation by COBRA-IIIC such that the entrance effect can be implanted into the distributed parameter analysis. The technique has demonstrated its applicability for a 7-rod bundle and the results of calculation were compared to those of three-dimensional analyses and experimental measurements.

  6. Metallic/semiconducting ratio of carbon nanotubes in a bundle ...

    Indian Academy of Sciences (India)

    SWCNTs) in a bundle by resonant Raman spectroscopy. The calculation has been done for the three peak positions in radial breathing mode (RBM) spectra obtained by using a laser excitation wavelength () of 633 nm from He–Ne laser on ...

  7. The fibre bundle anatomy of human cruciate ligaments

    NARCIS (Netherlands)

    Mommersteeg, T. J.; Kooloos, J. G.; Blankevoort, L.; Kauer, J. M.; Huiskes, R.; Roeling, F. Q.

    1995-01-01

    The cruciate ligaments of the knee consist of numerous fascicles, groups of which comprise fibre bundles. The stabilising function of these ligaments is established by changes in the lengths and orientations of the fascicles. Understanding the function of knee ligaments thus requires an

  8. Metabolic profiling of laser microdissected vascular bundles of Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Fiehn Oliver

    2005-08-01

    Full Text Available Abstract Background Laser microdissection is a useful tool for collecting tissue-specific samples or even single cells from animal and plant tissue sections. This technique has been successfully employed to study cell type-specific expression at the RNA, and more recently also at the protein level. However, metabolites were not amenable to analysis after laser microdissection, due to the procedures routinely applied for sample preparation. Using standard tissue fixation and embedding protocols to prepare histological sections, metabolites are either efficiently extracted by dehydrating solvents, or washed out by embedding agents. Results In this study, we used cryosectioning as an alternative method that preserves sufficient cellular structure while minimizing metabolite loss by excluding any solute exchange steps. Using this pre-treatment procedure, Arabidopsis thaliana stem sections were prepared for laser microdissection of vascular bundles. Collected samples were subsequently analyzed by gas chromatography-time of flight mass spectrometry (GC-TOF MS to obtain metabolite profiles. From 100 collected vascular bundles (~5,000 cells, 68 metabolites could be identified. More than half of the identified metabolites could be shown to be enriched or depleted in vascular bundles as compared to the surrounding tissues. Conclusion This study uses the example of vascular bundles to demonstrate for the first time that it is possible to analyze a comprehensive set of metabolites from laser microdissected samples at a tissue-specific level, given that a suitable sample preparation procedure is used.

  9. AdS 3-manifolds and Higgs bundles

    DEFF Research Database (Denmark)

    Alessandrini, Daniele; Li, Qiongling

    2017-01-01

    In this paper we investigate the relationships between closed AdS $3$-manifolds and Higgs bundles. We have a new way to construct AdS structures that allows us to see many of their properties explicitly, for example we can recover the very recent formula by Tholozan for their volume. We give natu...

  10. Heat transfer and fluid friction in bundles of twisted tubes

    Science.gov (United States)

    Dzyubenko, B. V.; Dreitser, G. A.

    1986-06-01

    The results of heat-transfer and friction studies in bundles of twisted tubes and rods with spiral wire-wrap spacers are analyzed, and recommendations are given for calculating the heat-transfer coefficient in heat exchangers using twisted tubes.

  11. Fission yeast Scp3 potentially maintains microtubule orientation through bundling.

    Directory of Open Access Journals (Sweden)

    Kanako Ozaki

    Full Text Available Microtubules play important roles in organelle transport, the maintenance of cell polarity and chromosome segregation and generally form bundles during these processes. The fission yeast gene scp3+ was identified as a multicopy suppressor of the cps3-81 mutant, which is hypersensitive to isopropyl N-3-chlorophenylcarbamate (CIPC, a poison that induces abnormal multipolar spindle formation in higher eukaryotes. In this study, we investigated the function of Scp3 along with the effect of CIPC in the fission yeast Schizosaccharomyces pombe. Microscopic observation revealed that treatment with CIPC, cps3-81 mutation and scp3+ gene deletion disturbed the orientation of microtubules in interphase cells. Overexpression of scp3+ suppressed the abnormal orientation of microtubules by promoting bundling. Functional analysis suggested that Scp3 functions independently from Ase1, a protein largely required for the bundling of the mitotic spindle. A strain lacking the ase1+ gene was more sensitive to CIPC, with the drug affecting the integrity of the mitotic spindle, indicating that CIPC has a mitotic target that has a role redundant with Ase1. These results suggested that multiple systems are independently involved to ensure microtubule orientation by bundling in fission yeast.

  12. MYOCARDIAL DEFORMATION AND COMPLETE LEFT BUNDLE BRANCH BLOCK

    Directory of Open Access Journals (Sweden)

    E. N. Pavlyukova

    2015-12-01

    Full Text Available Tissue Doppler imaging is evolving as a useful echocardiographic tool for quantitative assessment of left ventricular systolic and diastolic function. Over the last 10 years, myocardial deformation imaging has become possible initially with tissue Doppler , and more recently with myocardial speckle-tracking using 2D echocardiography. Unlike simple tissue velocity measurements, deformation measurements are specific for the region of interest. Strain rate or strain measurements have been used as sensitive indicators for subclinical diseases, and it is the most widely used tool to assess mechanical dyssynchrony. Left bundle branch block is a frequent, etiologically heterogeneous, clinically hostile and diagnostically challenging entity. About 2% of patients underwent cardiac stress testing show stable or intermittent left bundle branch block. Presence of left bundle branch block is associated with a lower and slower diastolic coronary flow velocity especially during hyperemia. Stress echocardiography is the best option for the diagnosis of ischemic heart disease, albeit specificity and sensitivity reduce in patients with left bundle branch block in the territory of left anterior descending artery in presence of initial septum dyskinesia.

  13. Anatomic Double-Bundle Anterior Cruciate Ligament Reconstruction

    NARCIS (Netherlands)

    Hofbauer, Marcus; Muller, Bart; Wolf, Megan; Forsythe, Brian; Fu, Freddie H.

    2013-01-01

    Over the past decade, intense research of the function of the 2 distinct bundles, the anteromedial and posterolateral, of the anterior cruciate ligament (ACL) has led to pronounced changes in the technical concepts of ACL reconstruction. Recently, the renewed focus of ACL reconstruction has been to

  14. Reminiscences Of The First His Bundle Electrography In India

    Directory of Open Access Journals (Sweden)

    Nambiar C.A

    2002-04-01

    Full Text Available Dr Onkar Narula was making a huge wave those days with his work on His Bundle Electrocardiography and Corrected Sinus Node Recovery Time. He visited us in late 1972 or early 1973,probably the latter date. Till then venous catheterizations (including pacing were done by open cut down. I remember the first time we used venous sheath through right femoral vein. Dr Bhatia was the operator and I was assisting him and Dr Savithri Srivasthava was the senior Registrar. With Dr Narula showing the way we did the first His Bundle Recording and I analysed the whole roll manually as was the method those days. We had to improvise a junction box as the recording equipment did not have a proper connecting accessory at that time. After Dr Narula left we did His Bundle recording on many more patients and undertook a study. This was published as: Effect of acute digitalization on His Bundle Intervals and Corrected Sinus Node Recovery Time in young adults.M.L.Bhatia,C.Ashokan Nambiar,S.Shrivastava and Sujoy B.Roy: Indian Heart Journal:Vol-2:1977.1The article was received for publication on 29/11/1973 as acknowledged underneath, but strangely it took a long time to come in print. I have preserved some of the cath rolls and reprint of the article.

  15. Frobenius pull backs of vector bundles in higher dimensions

    Indian Academy of Sciences (India)

    ... of a Frobenius pull back of is a refinement of the Frobenius pull back of the Harder–Narasimhan filtration of , provided there is a lower bound on the characteristic (in terms of rank of and the slope of the destabilizing sheaf of the cotangent bundle of ). We also recall some examples, due to Raynaud and Monsky, ...

  16. The Roach muscle bundle and umbilical cord coiling

    NARCIS (Netherlands)

    de Laat, Monique W. M.; Nikkels, Peter G. J.; Franx, Arie; Visser, Gerard H. A.

    2007-01-01

    To determine if presence of the Roach muscle, a small muscle bundle lying just beside the umbilical artery, contributes to umbilical cord coiling. 251 umbilical cords were examined. The umbilical coiling index (UCI) was calculated as the number of coils divided by the cord length in cm. Cords were

  17. Subanalytic bundles and tubular neighbourhoods of zero-loci

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    Abstract. We introduce the natural and fairly general notion of a subanalytic bundle. (with a finite dimensional vector space P of sections) on a subanalytic subset X of a real analytic manifold M, and prove that when M is compact, there is a Baire subset U of sections in P whose zero-loci in X have tubular neighbourhoods, ...

  18. On the classification of complex vector bundles of stable rank

    Indian Academy of Sciences (India)

    This classification becomes more effective on generalized flag manifolds, where the Lie algebra formalism and concrete integrability conditions describe in constructive terms the Chern classes of a vector bundle. ... Since deceased; Mathematics Department, University of California, Santa Barbara, CA 93106, USA ...

  19. On infinitesimal conformal transformations of the tangent bundles ...

    Indian Academy of Sciences (India)

    The metric. ˜g, which is called a synectic lift of the Riemannian metric g, was introduced by Talantova and Shirokov [4] to study the differential geometry of tangent bundles of Riemannian manifolds (for details, also see [5]). Their paper is concerned with the geometry of the space of n dual variables. The concept of a dual ...

  20. On the classification of complex vector bundles of stable rank

    Indian Academy of Sciences (India)

    According to previous observations, this would imply (under the above torsion conditions) a classification of all rank r complex vector bundles on X, for stable rank r ≥ n/2. A few partial answers to this question are known. For instance, a classical result of. Wu asserts that any couple of cohomology classes (c1,c2) ∈ H2(X, ...

  1. 2-d and 1-d Nanomaterials Construction through Peptide Computational Design and Solution Assembly

    Science.gov (United States)

    Pochan, Darrin

    Self-assembly of molecules is an attractive materials construction strategy due to its simplicity in application. By considering peptidic molecules in the bottom-up materials self-assembly design process, one can take advantage of inherently biomolecular attributes; intramolecular folding events, secondary structure, and electrostatic/H-bonding/hydrophobic interactions to define hierarchical material structure and consequent properties. Importantly, while biomimicry has been a successful strategy for the design of new peptide molecules for intermolecular assembly, computational tools have been developed to de novo design peptide molecules required for construction of pre-determined, desired nanostructures and materials. A new system comprised of coiled coil bundle motifs theoretically designed to assemble into designed, one and two-dimensional nanostructures will be introduced. The strategy provides the opportunity for arbitrary nanostructure formation, i.e. structures not observed in nature, with peptide molecules. Importantly, the desired nanostructure was chosen first while the peptides needed for coiled coil formation and subsequent nanomaterial formation were determined computationally. Different interbundle, two-dimensional nanostructures are stabilized by differences in amino acid composition exposed on the exterior of the coiled coil bundles. Computation was able to determine molecules required for different interbundle symmetries within two-dimensional sheets stabilized by subtle differences in amino acid composition of the inherent peptides. Finally, polymers were also created through covalent interactions between bundles that allowed formation of architectures spanning flexible network forming chains to ultra-stiff polymers, all with the same building block peptides. The success of the computational design strategy is manifested in the nanomaterial results as characterized by electron microscopy, scattering methods, and biophysical techniques. Support

  2. A case of ‘Masquerading’ bundle branch block: A forgotten concept

    OpenAIRE

    Dinesh Choudhary; Narayanan Namboodiri; Jaganmohan A. Tharakan

    2014-01-01

    ‘Masquerading’ bundle branch block (right bundle branch block in the precordial leads with left bundle branch block in frontal leads and left axis deviation) is seen most commonly with coronary artery disease and hypertension. No definite explanation is available so far for these changes. We are presenting a case of rare congenital intranuclear inclusion myopathy with congestive heart failure and ‘Masquerading’ bundle branch block in ECG.

  3. Structural Causes of Right Bundle Branch Block?Time for a Closer Look?

    OpenAIRE

    Ker, James

    2010-01-01

    Right bundle branch block is an electrocardiographic phenomenon with specific criteria. Currently, two specific forms of right bundle branch block are acknowledged, a proximal and a distal variant. A vast array of pathologies can cause proximal, distal or even combined forms of right bundle branch block. In this study it is suggested that a third type of right bundle branch block exist: one caused by a subaortic muscular tendon in the left ventricle, leading to an increased velocity of conduc...

  4. Lower complication rates for cranioplasty with peri-operative bundle.

    Science.gov (United States)

    Le, Catherine; Guppy, Kern H; Axelrod, Yekaterina V; Hawk, Mark W; Silverthorn, James; Inacio, Maria C; Akins, Paul T

    2014-05-01

    The overall benefits of craniectomy must include procedural risks from cranioplasty. Cranioplasty carries a high risk of surgical site infections (SSI) particularly with antibiotic resistant bacteria. The goal of this study was to measure the effect of a cranioplasty bundle on peri-operative complications. The authors queried a prospective, inpatient neurosurgery database at Kaiser Sacramento Medical Center for craniectomy and cranioplasty over a 7 year period. 57 patients who underwent cranioplasties were identified. A retrospective chart review was completed for complications, including surgical complications such as SSI, wound dehiscence, and re-do cranioplasty. We measured cranioplasty complication rates before and after implementation of a peri-operative bundle, which consisted of peri-operative vancomycin (4 doses), a barrier dressing through post-operative day (POD) 3, and de-colonization of the surgical incision using topical chlorhexidine from POD 4 to 7. The rate of MRSA colonization in cranioplasty patients is three times higher than the average seen on ICU admission screening (19% vs. 6%). The cranioplasty surgical complication rate was 22.8% and SSI rate was 10.5%. The concurrent SSI rate for craniectomy was 1.9%. Organisms isolated were methicillin-resistant Staphylococcus aureus (4), methicillin-sensitive S. aureus (1), Propionibacterium acnes (1), and Escherichia coli (1). Factors associated with SSI were peri-operative vancomycin (68.6% vs. 16.7%, p=0.0217). Complication rates without (n=21) and with (n=36) the bundle were: SSI (23.8% vs. 2.8%, p=0.0217) and redo cranioplasty (19% vs. 0%, p=0.0152). Bundle use did not affect rates for superficial wound dehiscence, seizures, or hydrocephalus. The cranioplasty bundle was associated with reduced SSI rates and the need for re-do cranioplasties. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. Early Results of Anatomic Double Bundle Anterior Cruciate Ligament Reconstruction

    Directory of Open Access Journals (Sweden)

    Demet Pepele

    2014-03-01

    Full Text Available Aim: The goal in anterior cruciate ligament reconstruction (ACLR is to restore the normal anatomic structure and function of the knee. In the significant proportion of patients after the traditional single-bundle ACLR, complaints of instability still continue. Anatomic double bundle ACLR may provide normal kinematics in knees, much closer to the natural anatomy. The aim of this study is to clinically assess the early outcomes of our anatomical double bundle ACLR. Material and Method: In our clinic between June 2009 and March 2010, performed the anatomic double bundle ACLR with autogenous hamstring grafts 20 patients were evaluated prospectively with Cincinnati, IKDC and Lysholm scores and in clinically for muscle strength and with Cybex II dynamometer. Results: The mean follow-up is 17.8 months (13-21 months. Patients%u2019 scores of Cincinnati, IKDC and Lysholm were respectively, preoperative 18.1, 39.3 and 39.8, while the post-op increased to 27.2, 76.3 and 86.3. In their last check, 17 percent of the patients according to IKDC scores (85% A (excellent and B (good group and 3 patients took place as C (adequate group. The power measurements of quadriceps and hamstring muscle groups of patients who underwent surgery showed no significant difference compared with the intact knees. Discussion: Double-bundle ACL reconstruction is a satisfactory method. There is a need comparative, long-term studies in large numbers in order to determine improving clinical outcome, preventing degeneration and restoring the knee biomechanics better.

  6. Brain natriutetic peptide test

    Science.gov (United States)

    ... medlineplus.gov/ency/article/007509.htm Brain natriuretic peptide test To use the sharing features on this page, please enable JavaScript. Brain natriuretic peptide (BNP) test is a blood test that measures ...

  7. Vasoactive intestinal peptide test

    Science.gov (United States)

    ... medlineplus.gov/ency/article/003508.htm Vasoactive intestinal peptide test To use the sharing features on this page, please enable JavaScript. Vasoactive intestinal peptide (VIP) is a test that measures the amount ...

  8. TRH-like peptides.

    Science.gov (United States)

    Bílek, R; Bičíková, M; Šafařík, L

    2011-01-01

    TRH-like peptides are characterized by substitution of basic amino acid histidine (related to authentic TRH) with neutral or acidic amino acid, like glutamic acid, phenylalanine, glutamine, tyrosine, leucin, valin, aspartic acid and asparagine. The presence of extrahypothalamic TRH-like peptides was reported in peripheral tissues including gastrointestinal tract, placenta, neural tissues, male reproductive system and certain endocrine tissues. Work deals with the biological function of TRH-like peptides in different parts of organisms where various mechanisms may serve for realisation of biological function of TRH-like peptides as negative feedback to the pituitary exerted by the TRH-like peptides, the role of pEEPam such as fertilization-promoting peptide, the mechanism influencing the proliferative ability of prostatic tissues, the neuroprotective and antidepressant function of TRH-like peptides in brain and the regulation of thyroid status by TRH-like peptides.

  9. PeptideAtlas

    Data.gov (United States)

    U.S. Department of Health & Human Services — PeptideAtlas is a multi-organism, publicly accessible compendium of peptides identified in a large set of tandem mass spectrometry proteomics experiments. Mass...

  10. The determinant bundle on the moduli space of stable triples over a ...

    Indian Academy of Sciences (India)

    We construct a holomorphic Hermitian line bundle over the moduli space of stable triples of the form (1, 2, ), where 1 and 2 are holomorphic vector bundles over a fixed compact Riemann surface , and : 2 → 1 is a holomorphic vector bundle homomorphism. The curvature of the Chern connection of this ...

  11. Lexical Bundles in Chinese Undergraduate Academic Writing at an English Medium University

    Science.gov (United States)

    Ruan, Zhoulin

    2017-01-01

    This paper investigates the use of lexical bundles in Chinese students' academic writing across different levels of studies at an English medium university. Frequency-based bundles were retrieved from a corpus of student academic texts written at four points of time between Year 1 and Year 4, and the structures and functions of the bundles were…

  12. Peptide Nucleic Acids

    DEFF Research Database (Denmark)

    2003-01-01

    A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker....

  13. Peptide Nucleic Acids (PNA)

    DEFF Research Database (Denmark)

    2002-01-01

    A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker....

  14. Peptide Nucleic Acids

    DEFF Research Database (Denmark)

    1998-01-01

    A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker....

  15. PH dependent adhesive peptides

    Science.gov (United States)

    Tomich, John; Iwamoto, Takeo; Shen, Xinchun; Sun, Xiuzhi Susan

    2010-06-29

    A novel peptide adhesive motif is described that requires no receptor or cross-links to achieve maximal adhesive strength. Several peptides with different degrees of adhesive strength have been designed and synthesized using solid phase chemistries. All peptides contain a common hydrophobic core sequence flanked by positively or negatively charged amino acids sequences.

  16. Antimicrobial Peptides in 2014

    Directory of Open Access Journals (Sweden)

    Guangshun Wang

    2015-03-01

    Full Text Available This article highlights new members, novel mechanisms of action, new functions, and interesting applications of antimicrobial peptides reported in 2014. As of December 2014, over 100 new peptides were registered into the Antimicrobial Peptide Database, increasing the total number of entries to 2493. Unique antimicrobial peptides have been identified from marine bacteria, fungi, and plants. Environmental conditions clearly influence peptide activity or function. Human α-defensin HD-6 is only antimicrobial under reduced conditions. The pH-dependent oligomerization of human cathelicidin LL-37 is linked to double-stranded RNA delivery to endosomes, where the acidic pH triggers the dissociation of the peptide aggregate to release its cargo. Proline-rich peptides, previously known to bind to heat shock proteins, are shown to inhibit protein synthesis. A model antimicrobial peptide is demonstrated to have multiple hits on bacteria, including surface protein delocalization. While cell surface modification to decrease cationic peptide binding is a recognized resistance mechanism for pathogenic bacteria, it is also used as a survival strategy for commensal bacteria. The year 2014 also witnessed continued efforts in exploiting potential applications of antimicrobial peptides. We highlight 3D structure-based design of peptide antimicrobials and vaccines, surface coating, delivery systems, and microbial detection devices involving antimicrobial peptides. The 2014 results also support that combination therapy is preferred over monotherapy in treating biofilms.

  17. Peptide Nucleic Acid Synthons

    DEFF Research Database (Denmark)

    2004-01-01

    A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker....

  18. C-Peptide Test

    Science.gov (United States)

    ... Weisenberger, J. (2013 March) Why Does a C-Peptide Test Matter? Diabetes Forecast [On-line information]. Available online at http:// ... Updated). What is c-peptide? What do c-peptide levels mean? Misc.health.diabetes, diabetes FAQ [On-line information from newsgroup]. Available ...

  19. Self-assembly of fibronectin mimetic peptide-amphiphile nanofibers

    Science.gov (United States)

    Rexeisen, Emilie Lynn

    umbilical vein endothelial cells and alpha5beta1 integrins immobilized on an AFM tip preferred binding to a fibronectin mimetic peptide that contained both hydrophilic and hydrophobic residues in the linker and a medium length spacer. Most cells require a three-dimensional scaffold in order to thrive. To incorporate the fibronectin mimetic peptide into a three-dimensional structure, a single hydrocarbon tail was attached to form a peptideamphiphile. Single-tailed peptide-amphiphiles have been shown to form nanofibers in solution and gel after screening of the electrostatic charges in the headgroup. These gels show promise as scaffolds for tissue engineering. A fibronectin mimetic peptide-amphiphile containing a linker with alternating hydrophobic and hydrophilic residues was designed to form nanofibers in solution. The critical micelle concentration of the peptide-amphiphile was determined to be 38 muM, and all subsequent experiments were performed above this concentration. Circular dichroism (CD) spectroscopy indicated that the peptide headgroup of the peptide-amphiphile forms an alpha+beta secondary structure; whereas, the free peptide forms a random secondary structure. Cryogenic-transmission electron microscopy (cryo-TEM) and small angle neutron scattering showed that the peptide-amphiphile self-assembled into nanofibers. The cryo-TEM images showed single nanofibers with a diameter of 10 nm and lengths on the order of microns. Images of higher peptideamphiphile concentrations showed evidence of bundling between individual nanofibers, which could give rise to gelation behavior at higher concentrations. The peptide-amphiphile formed a gel at concentrations above 6 mM. A 10 mM sample was analyzed with oscillating plate rheometry and was found to have an elastic modulus within the range of living tissue, showing potential as a possible scaffold for tissue engineering.

  20. Biomechanical comparisons of knee stability after anterior cruciate ligament reconstruction between 2 clinically available transtibial procedures: anatomic double bundle versus single bundle.

    Science.gov (United States)

    Kondo, Eiji; Merican, Azhar M; Yasuda, Kazunori; Amis, Andrew A

    2010-07-01

    Several trials have compared the clinical results between anatomic double-bundle and single-bundle anterior cruciate ligament reconstruction procedures. However, it remains controversial whether the anatomic double-bundle procedure is superior to the single-bundle procedure. The anatomic double-bundle procedure will be better than the single-bundle procedure at resisting anterior laxity, internal rotation laxity, and pivot-shift instability. Controlled laboratory study. Eight cadaveric knees were tested in a 6 degrees of freedom rig using the following loading conditions: 90-N anterior tibialforce, 5-N.m internal and external tibial torques, and a simulated pivot-shift test. Tibiofemoral kinematics during the flexion-extension cycle were recorded with an optical tracking system for (1) intact, (2) anterior cruciate ligament-deficient knee, (3) anatomic double-bundle reconstruction, and (4) single-bundle reconstruction placed at 11 o'clock in the intercondylar notch. There were significant reductions of anterior laxity of 3.5 mm at 20 degrees of flexion, internal rotational laxity of 2.5 degrees at 20 degrees of flexion, and anterior translations (2 mm) and internal rotations (5 degrees ) in the simulated pivot-shift test in the double-bundle reconstruction com-pared with the single-bundle reconstruction. There were no significant differences between the 2 procedures for external rotation laxity. The postoperative anterior translation and internal rotation stability after anatomic double-bundle anterior cruciate ligament reconstruction were significantly better than after single-bundle reconstruction, in both static tests and the pivot shift. Unlike previous laboratory studies, this work used clinical arthroscopic methods for anterior cruciate ligament reconstruction, and found that the anatomic reconstruction was superior to a single graft placed at 11 o'clock.

  1. Hierarchical mordenite zeolite nano-rods bundles favourable to bulky molecules

    Science.gov (United States)

    Dai, Guang; Hao, Wenming; Xiao, Huan; Ma, Jinghong; Li, Ruifeng

    2017-10-01

    Hierarchical mordenite zeolite nano-rods bundles were successfully synthesized by a novel approach of using organosilane functioned fumed silica as silicon source. The organic moiety linked on the surface of fumed silica inhibits the growth of zeolite crystal into large size, leading to the nano-rods assembled bundles. The mordenite nanorods bundles exhibited significantly improved mesitylene adsorption capacity compared with the conventional mordenite. As a catalyst, the hierarchical mordenite nanorods bundles showed remarkable catalytic performance in the benzylation of mesitylene by benzyl chloride, due to the efficient diffusion rate and improved accessibility of the active sites in the hierarchical mordenite nanorods bundles.

  2. A case of an infant with bundle branch reentrant ventricular tachycardia

    Directory of Open Access Journals (Sweden)

    Satoki Fujii

    2012-04-01

    Full Text Available Catheter ablation of the right bundle branch was performed on an 11-month-old infant for the treatment of drug-resistant bundle branch reentrant ventricular tachycardia. The occurrence of right bundle branch block could not be used as an endpoint of treatment because the patient had presented with incomplete right bundle branch block pattern during sinus rhythm. We performed ablation of the right bundle branch and utilized changes of duration and morphology of the QRS complex as indicators. Eight years have passed with no development of any atrioventricular block or tachycardia episode.

  3. Transport of single cells using an actin bundle-myosin bionanomotor transport system

    Energy Technology Data Exchange (ETDEWEB)

    Takatsuki, Hideyo; Rice, Kevin M; Kohama, Kazuhiro; Blough, Eric R [Department of Biological Sciences, Marshall University, Huntington, WV (United States); Tanaka, Hideyuki [Department of Molecular and Cellular Pharmacology, Gunma University Graduate School of Medicine, Maebashi (Japan); Kolli, Madhukar B; Nalabotu, Siva K [Center for Diagnostic Nanosystems, Marshall University, Huntington, WV (United States); Famouri, Parviz, E-mail: blough@marshall.edu [Lane Department of Computer Science and Electrical Engineering, West Virginia University, Morgantown, WV (United States)

    2011-06-17

    The potential of using actin bundles for the transport of liposomes and single cells across myosin-coated surfaces is investigated. Compared to that observed with filamentous actin, the liposome transport using actin bundles was more linear in nature and able to occur over longer distances. Bundles, but not filamentous actin, were capable of moving single cells. Cargo unloading from bundles was achieved by incubation with Triton X-100. These data suggest that actin bundling may improve the ability of the myosin motor system for nanotransport applications.

  4. Analysis of Subchannel and Rod Bundle PSBT Experiments with CATHARE 3

    Directory of Open Access Journals (Sweden)

    M. Valette

    2012-01-01

    Full Text Available This paper presents the assessment of CATHARE 3 against PWR subchannel and rod bundle tests of the PSBT benchmark. Noticeable measurements were the following: void fraction in single subchannel and rod bundle, multiple liquid temperatures at subchannel exit in rod bundle, and DNB power and location in rod bundle. All these results were obtained both in steady and transient conditions. Void fraction values are satisfactory predicted by CATHARE 3 in single subchannels with the pipe module. More dispersed predictions of void values are obtained in rod bundles with the CATHARE 3 3D module at subchannel scale. Single-phase liquid mixing tests and DNB tests in rod bundle are also analyzed. After calibrating the mixing in liquid single phase with specific tests, DNB tests using void mixing give mitigated results, perhaps linked to inappropriate use of CHF lookup tables in such rod bundles with many spacers.

  5. Anatomic Double-Bundle Anterior Cruciate Ligament Reconstruction Using In Situ Hamstring Graft With 4 Tunnels

    Science.gov (United States)

    Wagih, Ahmad M.

    2013-01-01

    A careful review of the literature suggests that a significant number of patients undergoing anterior cruciate ligament (ACL) reconstruction have less-than-optimal results. Although overall outcomes of ACL reconstruction are favorable, there remains considerable room for improvement. Anatomically, the ACL consists of 2 major functional bundles, the anteromedial bundle and the posterolateral bundle. Biomechanically, both bundles contribute significantly to the anterior and rotational stability of the knee. Therefore anatomic double-bundle ACL reconstruction techniques may further improve the outcomes in ACL surgery. This article presents a technique for arthroscopic double-bundle ACL reconstruction that includes the use of 2 femoral and 2 tibial tunnels to restore both the anteromedial and posterolateral bundles of the ACL with minimal hardware for fixation. PMID:24749023

  6. Cosmic multi-muon bundles measured at DELPHI

    CERN Document Server

    Travnicek, Petr

    2002-01-01

    The DELPHI detector at LEP, located 100 $m$ underground, has been used to detect the multi-muon bundles by cathode readout of its hadron calorimeter and its tracking detectors (TPC, muon chambers). The experimental apparatus allows us to study muon bundles originating from primary cosmic particles with energies in the interval $10^{14}$ - $10^{17} eV$. The cosmic events registered during the years 1999 and 2000 correspond roughly to $1.6 10^6 s$ of effective run time. The aim of the work is to compare the measured muon multiplicity distributions and predictions of high energy interaction models for different types of primary particles and also to determine the absolute flux of events in certain muon multiplicity range. The presentation describes the current status of the analysis.

  7. Catastrophic Failure and Critical Scaling Laws of Fiber Bundle Material

    Directory of Open Access Journals (Sweden)

    Shengwang Hao

    2017-05-01

    Full Text Available This paper presents a spring-fiber bundle model used to describe the failure process induced by energy release in heterogeneous materials. The conditions that induce catastrophic failure are determined by geometric conditions and energy equilibrium. It is revealed that the relative rates of deformation of, and damage to the fiber bundle with respect to the boundary controlling displacement ε0 exhibit universal power law behavior near the catastrophic point, with a critical exponent of −1/2. The proportion of the rate of response with respect to acceleration exhibits a linear relationship with increasing displacement in the vicinity of the catastrophic point. This allows for the prediction of catastrophic failure immediately prior to failure by extrapolating the trajectory of this relationship as it asymptotes to zero. Monte Carlo simulations are completed and these two critical scaling laws are confirmed.

  8. An improved partial bundle method for linearly constrained minimax problems

    Directory of Open Access Journals (Sweden)

    Chunming Tang

    2016-02-01

    Full Text Available In this paper, we propose an improved partial bundle method for solving linearly constrained minimax problems. In order to reduce the number of component function evaluations, we utilize a partial cutting-planes model to substitute for the traditional one. At each iteration, only one quadratic programming subproblem needs to be solved to obtain a new trial point. An improved descent test criterion is introduced to simplify the algorithm. The method produces a sequence of feasible trial points, and ensures that the objective function is monotonically decreasing on the sequence of stability centers. Global convergence of the algorithm is established. Moreover, we utilize the subgradient aggregation strategy to control the size of the bundle and therefore overcome the difficulty of computation and storage. Finally, some preliminary numerical results show that the proposed method is effective.

  9. Analyses of bundle experiment data using MATRA-h

    Energy Technology Data Exchange (ETDEWEB)

    Lim, In Cheol; Chea, Hee Taek [Korea Atomic Energy Research Institute, Taejon (Korea)

    1998-06-01

    When the construction and operation license for HANARO was renewed in 1995, 25% of CHF penalty was imposed. The reason for this was that the validation work related to the CHF design calculation was not enough for the assurance of CHF margin. As a part of the works to recover this CHF penalty, MATRA-h was developed by implementing the new correlations for the heat transfer, CHF prediction, subcooled void to the MATRA-a, which is the modified version of COBRA-IV-I done by KAERI. Using MATRA-h, the subchannel analyses for the bundle experiment data were performed. The comparison of the code predictions with the experimental results, it was found that the code would give the conservative predictions as far as the CHF in the bundle geometry is concerned. (author). 12 refs., 25 figs., 16 tabs.

  10. Through silicon vias filled with planarized carbon nanotube bundles.

    Science.gov (United States)

    Wang, Teng; Jeppson, Kjell; Olofsson, Niklas; Campbell, Eleanor E B; Liu, Johan

    2009-12-02

    The feasibility of using carbon nanotube (CNT) bundles as the fillers of through silicon vias (TSVs) has been demonstrated. CNT bundles are synthesized directly inside TSVs by thermal chemical vapor deposition (TCVD). The growth of CNTs in vias is found to be highly dependent on the geometric dimensions and arrangement patterns of the vias at atmospheric pressure. The CNT-Si structure is planarized by a combined lapping and polishing process to achieve both a high removal rate and a fine surface finish. Electrical tests of the CNT TSVs have been performed and their electrical resistance was found to be in the few hundred ohms range. The reasons for the high electrical resistance have been discussed and possible methods to decrease the electrical resistance have been proposed.

  11. Buckling of a fiber bundle embedded in epoxy

    Science.gov (United States)

    Hahn, H. T.; Sohi, M. M.

    1986-01-01

    Buckling of a fiber bundle embedded in epoxy resin was studied to gain insight into compressive failure mechanisms in unidirectional composites. The fibers used were E-glass, T300 graphite, T700 graphite, and P75 graphite. These fibers were combined with two different resins: Epon 815/V140 and Epon 828/Z. In both resins the failure mode of the bundle was found to be microbuckling of fibers for the first three types of fibers; however, the high-modulus P75 fibers failed in shear without any sign of microbuckling. The strains at which microbuckling occurred were higher than the compressive failure strains of the corresponding unidirectional composites. In the soft resin, Epon 815/V140, fibers buckled at lower strains than in the stiff resin, Epon 828/Z. The buckling strains and the segment lengths followed the trends predicted for a single filament embedded in an infinite matrix.

  12. Bundle adjustment with raw inertial observations in UAV applications

    Science.gov (United States)

    Cucci, Davide Antonio; Rehak, Martin; Skaloud, Jan

    2017-08-01

    It is well known that accurate aerial position and attitude control is beneficial for image orientation in airborne photogrammetry. The aerial control is traditionally obtained by Kalman filtering/smoothing inertial and GNSS observations prior to the bundle-adjustment. However, in Micro Aerial Vehicles this process may result in poor attitude determination due to the limited quality of the inertial sensors, large alignment uncertainty and residual correlations between sensor biases and initial attitude. We propose to include the raw inertial observations directly into the bundle-adjustment instead of as position and attitude weighted observations from a separate inertial/GNSS fusion step. The necessary observation models are derived in detail within the context of the so called ;Dynamic Networks;. We examine different real world cases and we show that the proposed approach is superior to the established processing pipeline in challenging scenarios such as mapping in corridors and in areas where the reception of GNSS signals is denied.

  13. Balanced metrics for vector bundles and polarised manifolds

    DEFF Research Database (Denmark)

    Garcia Fernandez, Mario; Ross, Julius

    2012-01-01

    We consider a notion of balanced metrics for triples (X, L, E) which depend on a parameter α, where X is smooth complex manifold with an ample line bundle L and E is a holomorphic vector bundle over X. For generic choice of α, we prove that the limit of a convergent sequence of balanced metrics...... leads to a Hermitian-Einstein metric on E and a constant scalar curvature Kähler metric in c_1(L). For special values of α, limits of balanced metrics are solutions of a system of coupled equations relating a Hermitian-Einstein metric on E and a Kähler metric in c1(L). For this, we compute the top two...

  14. A note on the tangent bundle of G/P

    Indian Academy of Sciences (India)

    Introduction. Let G be a simple linear algebraic group defined over C. Fix a proper parabolic subgroup. G/P. In [1], a Kähler–Einstein metric on G/P was constructed. This implies that the tangent bundle T (G/P ) is polystable (the definition is recalled below). We show that. T (G/P ) is stable. Since T (G/P ) is polystable, ...

  15. Optimal bundling of transmembrane helices using sparse distance constraints

    OpenAIRE

    Sale, Ken; Faulon, Jean-Loup; Genetha A. Gray; Schoeniger, Joseph S.; Young, Malin M.

    2004-01-01

    We present a two-step approach to modeling the transmembrane spanning helical bundles of integral membrane proteins using only sparse distance constraints, such as those derived from chemical cross-linking, dipolar EPR and FRET experiments. In Step 1, using an algorithm, we developed, the conformational space of membrane protein folds matching a set of distance constraints is explored to provide initial structures for local conformational searches. In Step 2, these structures refined against ...

  16. Higgs Bundles and Representations of Complex Hyperbolic Lattices

    OpenAIRE

    Maubon, Julien

    2015-01-01

    International audience; This paper is an introduction to the Higgs bundle theory of Hitchin and Simpson and a survey of its applications to the study of representations of complex hyperbolic lattices into Lie groups of Hermitian type. Some material concerning representations of surface groups will be covered but we shall be mainly interested in higher dimensional lattices, in particular in the proof of the rigidity of maximal representations of such lattices. (Concerning the rigidity of maxim...

  17. Image processing for cameras with fiber bundle image relay.

    Science.gov (United States)

    Olivas, Stephen J; Arianpour, Ashkan; Stamenov, Igor; Morrison, Rick; Stack, Ron A; Johnson, Adam R; Agurok, Ilya P; Ford, Joseph E

    2015-02-10

    Some high-performance imaging systems generate a curved focal surface and so are incompatible with focal plane arrays fabricated by conventional silicon processing. One example is a monocentric lens, which forms a wide field-of-view high-resolution spherical image with a radius equal to the focal length. Optical fiber bundles have been used to couple between this focal surface and planar image sensors. However, such fiber-coupled imaging systems suffer from artifacts due to image sampling and incoherent light transfer by the fiber bundle as well as resampling by the focal plane, resulting in a fixed obscuration pattern. Here, we describe digital image processing techniques to improve image quality in a compact 126° field-of-view, 30 megapixel panoramic imager, where a 12 mm focal length F/1.35 lens made of concentric glass surfaces forms a spherical image surface, which is fiber-coupled to six discrete CMOS focal planes. We characterize the locally space-variant system impulse response at various stages: monocentric lens image formation onto the 2.5 μm pitch fiber bundle, image transfer by the fiber bundle, and sensing by a 1.75 μm pitch backside illuminated color focal plane. We demonstrate methods to mitigate moiré artifacts and local obscuration, correct for sphere to plane mapping distortion and vignetting, and stitch together the image data from discrete sensors into a single panorama. We compare processed images from the prototype to those taken with a 10× larger commercial camera with comparable field-of-view and light collection.

  18. Bundle Data Approach at GES DISC Targeting Natural Hazards

    Science.gov (United States)

    Shie, Chung-Lin; Shen, Suhung; Kempler, Steven J.

    2015-01-01

    Severe natural phenomena such as hurricane, volcano, blizzard, flood and drought have the potential to cause immeasurable property damages, great socioeconomic impact, and tragic loss of human life. From searching to assessing the Big, i.e., massive and heterogeneous scientific data (particularly, satellite and model products) in order to investigate those natural hazards, it has, however, become a daunting task for Earth scientists and applications researchers, especially during recent decades. The NASA Goddard Earth Sciences Data and Information Service Center (GES DISC) has served Big Earth science data, and the pertinent valuable information and services to the aforementioned users of diverse communities for years. In order to help and guide our users to online readily (i.e., with a minimum effort) acquire their requested data from our enormous resource at GES DISC for studying their targeted hazard event, we have thus initiated a Bundle Data approach in 2014, first targeting the hurricane event topic. We have recently worked on new topics such as volcano and blizzard. The bundle data of a specific hazard event is basically a sophisticated integrated data package consisting of a series of proper datasets containing a group of relevant (knowledge--based) data variables readily accessible to users via a system-prearranged table linking those data variables to the proper datasets (URLs). This online approach has been developed by utilizing a few existing data services such as Mirador as search engine; Giovanni for visualization; and OPeNDAP for data access, etc. The online Data Cookbook site at GES DISC is the current host for the bundle data. We are now also planning on developing an Automated Virtual Collection Framework that shall eventually accommodate the bundle data, as well as further improve our management in Big Data.

  19. Weak point property and sections of Picard bundles on a ...

    Indian Academy of Sciences (India)

    Introduction. Debarre had proved that the Jacobian J0(X0) of a smooth curve X0 satisfies the diagonal property (Corollary 2.2 of [6]) i.e., there is a vector bundle of rank equal to the dimension of J0(X0) over J0(X0) × J0(X0), having a section whose zero scheme is the diagonal of J0(X0) × J0(X0). In this note, we generalize ...

  20. Determinants of contractile forces generated in disorganized actomyosin bundles.

    Science.gov (United States)

    Kim, Taeyoon

    2015-04-01

    Actomyosin machinery is a fundamental engine consisting mostly of actin filaments, molecular motors, and passive cross-linkers, generating mechanical forces required for biological processes of non-muscle cells such as cell migration, cytokinesis, and morphogenesis. Although the molecular and physical properties of key elements in the actomyosin machinery have been characterized well, it still remains unclear how macroscopic force buildup and dissipation in actomyosin networks and bundles depend on the microscopic properties of individual cytoskeletal components and their local interactions. To bridge such a gap between macroscopic and microscopic scales, we have developed a three-dimensional computational model of actomyosin bundles clamped to an elastic substrate with minimal components: actin filaments, passive cross-linkers, and active motors. Our model accounts for several key features neglected by previous studies despite their significance for force generation, such as realistic structure and kinetics of the motors. Using the model, we systematically investigated how net tension in actomyosin bundles is governed via interplay between motors and cross-linkers. We demonstrated motors can generate large tension on a bundle in the absence of cross-linkers in a very inefficient, unstable manner. Cross-linkers help motors to generate their maximum potential forces as well as enhance overall connectivity, leading to much higher efficiency and stability. We showed further that the cross-linkers behave as a molecular clutch with tunable friction which has quite distinct effects on net tension depending on their cross-linking angles. We also examined the source of symmetry breaking between tensile and compressive forces during tension generation process and discussed how the length and dynamics of actin filaments and the stiffness of the elastic substrate can affect the generated tension.

  1. HYDRODISSECTION FOR PRESERVATION OF NEUROVASCULAR BUNDLE DURING RADICAL PROSTATECTOMY

    Directory of Open Access Journals (Sweden)

    H. S. Gevorgyan

    2016-01-01

    Full Text Available Nerve-sparing radical prostatectomy is one of the high-tech operations in urology, and the challenge of the surgeon is not only to remove the prostate tumor, but also to provide a high quality of life. The fact that most questions devoted from patients in a conversation with the surgeon before the operation are devoted to this issue, shows the importance and relevance. At present, the diagnostic methods allow significantly more likely to detect early  prostate cancer, making finding and treatment of these patients more affordable and allows to apply this operation.Lately, it seems urgent to explore the possibility of water jet dissection in the field of urology, in particular, for nerve-sparing prostatectomy. Preservation of erectile function depends largely on the quality of separating the neurovascular bundle. Standard use of electrocautery is associated with damage to the neurovascular bundle.  When performing operations using water-jet mobilization of prostate the selective dissection of tissue is performed. This avoids injury of neurovascular bundle and further postoperative complications. The use of this technique may allow the surgeon to provide a more accurate mobilization prostate and selectively controlled intersection vessels heading to the prostate from the neurovascular bundle, reduce intraoperative blood loss,  maintaining continence, erectile function.This literature review is considered by the experience of using nerve-sparing radical prostatectomy using a water-jet dissector, estimated intraoperative parameters using this method.However, we have the lack of extensive research capabilities of this technique when performing nerve-preserving radical prostatectomy, that does not allow to make a comprehensive presentation on the benefits of this technique and its effects on erectile function and quality of urination, further study of this issue in such a difficult category of patients.

  2. Fluorescence Endoscopy in vivo based on Fiber-bundle Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Zufiria, B.; Gomez-Garcia, P.; Stamatakis, K.; Vaquero, J.J.; Fresno, M.; Desco, M.; Ripoll, J.; Arranz, A.

    2016-07-01

    High-resolution imaging techniques have become important for the determination of the cellular organization that is coupled to organ function. In many cases the organ can be viewed without the need of ionizing radiation techniques in an easier way. This is the case of the gastrointestinal tract, an organ that can be directly accessed with endoscopy avoiding any invasive procedure. Here we describe the design, assembly and testing of a fluorescence high-resolution endoscope intended for the study of the cellular organization of the colon in an experimental mouse model of colon carcinoma. Access to the colon of the mouse took place using a fiber-optic bundle that redirects the light coming from a LED to produce fluorescence and detect it back through the fiber bundle. Results from in vivo and ex-vivo test using our fluorescence fiber bundle endoscope show altered tissue structure and destruction of the intestinal crypts in tumor-bearing areas compared with healthy tissue. (Author)

  3. Differential geometry of moduli spaces of quiver bundles

    Science.gov (United States)

    Biswas, Indranil; Schumacher, Georg

    2017-08-01

    Let P be a parabolic subgroup of a semisimple affine algebraic group G defined over C and X a compact Kähler manifold. L. Álvarez-Cónsul and O. García-Prada associated to these a quiver Q and representations of Q into holomorphic vector bundles on X (Álvarez-Cónsul and García-Prada, 2003) [1, 2]. Our aim here is to investigate the differential geometric properties of the moduli spaces of representations of Q into vector bundles on X. In particular, we construct a Hermitian form on these moduli spaces. A fiber integral formula is proved for this Hermitian form; this fiber integral formula implies that the Hermitian form is Kähler. We compute the curvature of this Kähler form. Under an assumption which says that X is a complex projective manifold, this Kähler form is realized as the curvature of a certain determinant line bundle equipped with a Quillen metric.

  4. Enhanced boiling heat transfer in horizontal test bundles

    Energy Technology Data Exchange (ETDEWEB)

    Trewin, R.R.; Jensen, M.K.; Bergles, A.E.

    1994-08-01

    Two-phase flow boiling from bundles of horizontal tubes with smooth and enhanced surfaces has been investigated. Experiments were conducted in pure refrigerant R-113, pure R-11, and mixtures of R-11 and R-113 of approximately 25, 50, and 75% of R-113 by mass. Tests were conducted in two staggered tube bundles consisting of fifteen rows and five columns laid out in equilateral triangular arrays with pitch-to-diameter ratios of 1.17 and 1.5. The enhanced surfaces tested included a knurled surface (Wolverine`s Turbo-B) and a porous surface (Linde`s High Flux). Pool boiling tests were conducted for each surface so that reference values of the heat transfer coefficient could be obtained. Boiling heat transfer experiments in the tube bundles were conducted at pressures of 2 and 6 bar, heat flux values from 5 to 80 kW/m{sup 2}s, and qualities from 0% to 80%, Values of the heat transfer coefficients for the enhanced surfaces were significantly larger than for the smooth tubes and were comparable to the values obtained in pool boiling. It was found that the performance of the enhanced tubes could be predicted using the pool boiling results. The degradation in the smooth tube heat transfer coefficients obtained in fluid mixtures was found to depend on the difference between the molar concentration in the liquid and vapor.

  5. Fabrication of CANFLEX bundle kit for irradiation test in NRU

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Moon Sung; Kwon, Hyuk Il; Ji, Chul Goo; Chang, Ho Il; Sim, Ki Seob; Suk, Ho Chun

    1997-10-01

    CANFLEX bundle kit was prepared at KAERI for the fabrication of complete bundle at AECL. Completed bundle will be used for irradiation test in NRU. Provisions in the `Quality Assurance Manual for HWR Fuel Projects,` `Manufacturing Plan` and `Quality Verification, Inspection and Test Plan` were implemented as appropriately for the preparation of CANFLEX kit. A set of CANFLEX kit consist of 43 fuel sheath of two different sizes with spacers, bearing pads and buttons attached, 2 pieces of end plates and 86 pieces of end caps with two different sizes. All the documents utilized as references for the fabrication such as drawings, specifications, operating instructions, QC instructions and supplier`s certificates are specified in this report. Especially, suppliers` certificates and inspection reports for the purchased material as well as KAERI`s inspection report are integrated as attachments to this report. Attached to this report are supplier`s certificates and KAERI inspection reports for the procured materials and KAERI QC inspection reports for tubes, pads, spacers, buttons, end caps, end plates and fuel sheath. (author). 37 refs.

  6. Compactifications of the Heterotic string with unitary bundles

    Energy Technology Data Exchange (ETDEWEB)

    Weigand, T.

    2006-05-23

    In this thesis we investigate a large new class of four-dimensional supersymmetric string vacua defined as compactifications of the E{sub 8} x E{sub 8} and the SO(32) heterotic string on smooth Calabi-Yau threefolds with unitary gauge bundles and heterotic five-branes. The first part of the thesis discusses the implementation of this idea into the E{sub 8} x E{sub 8} heterotic string. After specifying a large class of group theoretic embeddings featuring unitary bundles, we analyse the effective four-dimensional N=1 supergravity upon compactification. From the gauge invariant Kaehler potential for the moduli fields we derive a modification of the Fayet-Iliopoulos D-terms arising at one-loop in string perturbation theory. From this we conjecture a one-loop deformation of the Hermitian Yang-Mills equation and introduce the idea of {lambda}-stability as the perturbatively correct stability concept generalising the notion of Mumford stability valid at tree-level. We then proceed to a definition of SO(32) heterotic vacua with unitary gauge bundles in the presence of heterotic five-branes and find agreement of the resulting spectrum with the S-dual framework of Type I/Type IIB orientifolds. A similar analysis of the effective four-dimensional supergravity is performed. Further evidence for the proposed one-loop correction to the stability condition is found by identifying the heterotic corrections as the S-dual of the perturbative part of {pi}-stability as the correct stability concept in Type IIB theory. After reviewing the construction of holomorphic stable vector bundles on elliptically fibered Calabi-Yau manifolds via spectral covers, we provide semi-realistic examples for SO(32) heterotic vacua with Pati-Salam and MSSM-like gauge sectors. We finally discuss the construction of realistic vacua with flipped SU(5) GUT and MSSM gauge group within the E{sub 8} x E{sub 8} framework, based on the embedding of line bundles into both E{sub 8} factors. Some of the appealing

  7. Getting the Most from Your CD-ROM Dollars: The CD-ROM Bundle [and] The Pros and Cons of CD-ROM Bundling.

    Science.gov (United States)

    Sarjeant, Eric W.; O'Connor, Mary Ann

    1992-01-01

    Discusses and reviews CD-ROM bundles--i.e., hardware, software and CD-ROM kits--including their features, specifications, drawbacks, and prices. Recommends buying through mail order for the best selection and price. The pros and cons of bundling as a marketing strategy are discussed and a list of vendors is provided. (EA)

  8. One stage revision single-bundle anterior cruciate ligament reconstruction with impacted morselized bone graft following a failed double-bundle reconstruction

    Directory of Open Access Journals (Sweden)

    Ho Jong Ra

    2017-01-01

    Full Text Available Although double-bundle anterior cruciate ligament (ACL reconstruction has theoretical benefits such as more accurate reproduction of ACL anatomy, it is technically more demanding surgery. This report describes the case of a one stage revision single-bundle ACL reconstruction after primary double-bundle ACL reconstruction. A professional dancer had an ACL previously reconstructed with a double-bundle technique, but the femoral tunnels were malpositioned resulting in residual laxity and rotational instability. The previous femoral tunnel positions were vertical and widened. The previous vertical tunnels were filled with impacted bone graft and a revision single-bundle ACL reconstruction was performed via the new femoral tunnel with a 2 O'clock position between the previous two tunnels. After 10 months of postoperative rehabilitation, the patient returned to professional dancing with sound bony union and without any residual instability.

  9. Double-bundle depiction of the anterior cruciate ligament at 3 Tesla

    Energy Technology Data Exchange (ETDEWEB)

    Adriaensen, M.E.A.P.M. [Atrium Medical Center Parkstad, Department of Radiology, Heerlen (Netherlands); Hogan, B. [Sports Surgery Clinic, Department of Radiology, Dublin (Ireland); Al-Bulushi, H.I.J. [Armed Forces Hospital, Department of Radiology, Muscat (Oman); Kavanagh, E.C. [Mater Misericordiae Hospital, Department of Radiology, Dublin (Ireland)

    2012-07-15

    Magnetic resonance imaging on 3 Tesla (3T MRI) with arthroscopic correlation has proven to adequately identify the anteromedial bundle (AMB) and posterolateral bundle (PLB) in cadaver knees. The purpose of this study was to describe the depiction of ACL bundle anatomy on 3T MRI in daily practice. In a retrospective cohort study, we included 50 consecutive patients who underwent standard 3T MRI of the knee and had an intact ACL. Two musculoskeletal radiologists independently reviewed all scans for depiction of ACL bundle anatomy using standardized forms. Descriptive statistics were used. Twenty-three right knees (46%) and 27 left knees (54%) were included in the study. Mean age of the patients was 35 years (range 12 to 68 years); 37 patients were male (74%). ACL bundle anatomy was best depicted in the axial plane in 44 knees (88%) and in the coronal plane in six knees (12%). Two bundles were seen in 47 knees (94%). The AMB was completely seen in 45 knees (90%). The PLB was completely seen in 40 knees (80%). Both bundles were completely seen in 37 knees (76%). The double-bundle anatomy of the ACL is visualized in 94% of patients on 3T MRI. Because of potentially associated clinical benefits, we advocate to report separately on the anteromedial bundle and posterolateral bundle in case of anterior cruciate ligament injury of the knee. (orig.)

  10. New models of droplet deposition and entrainment for prediction of CHF in cylindrical rod bundles

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Haibin, E-mail: hb-zhang@xjtu.edu.cn [School of Chemical Engineering and Technology, Xi’an Jiaotong University, Xi’an 710049 (China); Department of Chemical Engineering, Imperial College, London SW7 2BY (United Kingdom); Hewitt, G.F. [Department of Chemical Engineering, Imperial College, London SW7 2BY (United Kingdom)

    2016-08-15

    Highlights: • New models of droplet deposition and entrainment in rod bundles is developed. • A new phenomenological model to predict the CHF in rod bundles is described. • The present model is well able to predict CHF in rod bundles. - Abstract: In this paper, we present a new set of model of droplet deposition and entrainment in cylindrical rod bundles based on the previously proposed model for annuli (effectively a “one-rod” bundle) (2016a). These models make it possible to evaluate the differences of the rates of droplet deposition and entrainment for the respective rods and for the outer tube by taking into account the geometrical characteristics of the rod bundles. Using these models, a phenomenological model to predict the CHF (critical heat flux) for upward annular flow in vertical rod bundles is described. The performance of the model is tested against the experimental data of Becker et al. (1964) for CHF in 3-rod and 7-rod bundles. These data include tests in which only the rods were heated and data for simultaneous uniform and non-uniform heating of the rods and the outer tube. It was shown that the predicted CHFs by the present model agree well with the experimental data and with the experimental observation that dryout occurred first on the outer rods in 7-rod bundles. It is expected that the methodology used will be generally applicable in the prediction of CHF in rod bundles.

  11. Modelling of fuel bundle deformation at high temperatures: requirements, models and steps for consideration

    Energy Technology Data Exchange (ETDEWEB)

    Xu, S.; Xu, Z.; Fan, H.; Nitheanandan, T. [Atomic Energy of Canada Limited, MIssissauga, Ontario (Canada)

    2010-07-01

    To model thermal mechanical bundle deformation behaviour under high temperature conditions, several factors need to be considered. These are the sources of loads, deformation mechanisms, interactions within bundle components, bundle and pressure tube (PT) interaction, and boundary constraints on the fuel bundles under in-reactor conditions. This paper describes the modelling of the following three processes: Bundle slumping due to high temperature creep-sag of individual elements and endplates; Differential element expansion and fuel element bowing; and, Bundle distortion under axial loads. To model these processes, a number of key mechanisms for bundle deformation must be considered, which include: 1) Interaction of fuel elements in a bundle with their neighbours, 2) Endplate deformation, 3) Fuel elements lateral deformation under various loads and mechanisms, 4) Interaction within a fuel element, 5) Material property change at high temperatures, 6) Transient response of a bundle, and 7) Bundle configuration change. This paper summarises the new models needed for the mechanistic modelling of the key mechanisms mentioned above and provides an example to show how an endplate plasticity model is developed with results. (author)

  12. Topical peptides as cosmeceuticals

    Directory of Open Access Journals (Sweden)

    Varadraj Vasant Pai

    2017-01-01

    Full Text Available Peptides are known to have diverse biological roles, most prominently as signaling/regulatory molecules in a broad variety of physiological processes including defense, immunity, stress, growth, homeostasis and reproduction. These aspects have been used in the field of dermatology and cosmetology to produce short, stable and synthetic peptides for extracellular matrix synthesis, pigmentation, innate immunity and inflammation. The evolution of peptides over the century, which started with the discovery of penicillin, has now extended to their usage as cosmeceuticals in recent years. Cosmeceutical peptides may act as signal modulators of the extracellular matrix component, as structural peptides, carrier peptides and neurotransmitter function modulators. Transdermal delivery of peptides can be made more effective by penetration enhancers, chemical modification or encapsulation of peptides. The advantages of using peptides as cosmeceuticals include their involvement in many physiological functions of the skin, their selectivity, their lack of immunogenicity and absence of premarket regulatory requirements for their use. However, there are disadvantages: clinical evidence for efficacy is often weak, absorption may be poor due to low lipophilicity, high molecular weight and binding to other ingredients, and prices can be quite high.

  13. Antimicrobial Peptides in Reptiles

    Science.gov (United States)

    van Hoek, Monique L.

    2014-01-01

    Reptiles are among the oldest known amniotes and are highly diverse in their morphology and ecological niches. These animals have an evolutionarily ancient innate-immune system that is of great interest to scientists trying to identify new and useful antimicrobial peptides. Significant work in the last decade in the fields of biochemistry, proteomics and genomics has begun to reveal the complexity of reptilian antimicrobial peptides. Here, the current knowledge about antimicrobial peptides in reptiles is reviewed, with specific examples in each of the four orders: Testudines (turtles and tortosises), Sphenodontia (tuataras), Squamata (snakes and lizards), and Crocodilia (crocodilans). Examples are presented of the major classes of antimicrobial peptides expressed by reptiles including defensins, cathelicidins, liver-expressed peptides (hepcidin and LEAP-2), lysozyme, crotamine, and others. Some of these peptides have been identified and tested for their antibacterial or antiviral activity; others are only predicted as possible genes from genomic sequencing. Bioinformatic analysis of the reptile genomes is presented, revealing many predicted candidate antimicrobial peptides genes across this diverse class. The study of how these ancient creatures use antimicrobial peptides within their innate immune systems may reveal new understandings of our mammalian innate immune system and may also provide new and powerful antimicrobial peptides as scaffolds for potential therapeutic development. PMID:24918867

  14. Structure of the terminal PCP domain of the non-ribosomal peptide synthetase in teicoplanin biosynthesis.

    Science.gov (United States)

    Haslinger, Kristina; Redfield, Christina; Cryle, Max J

    2015-04-01

    The biosynthesis of the glycopeptide antibiotics, of which teicoplanin and vancomycin are representative members, relies on the combination of non-ribosomal peptide synthesis and modification of the peptide by cytochrome P450 (Oxy) enzymes while the peptide remains bound to the peptide synthesis machinery. We have structurally characterized the final peptidyl carrier protein domain of the teicoplanin non-ribosomal peptide synthetase machinery: this domain is believed to mediate the interactions with tailoring Oxy enzymes in addition to its function as a shuttle for intermediates between multiple non-ribosomal peptide synthetase domains. Using solution state NMR, we have determined structures of this PCP domain in two states, the apo and the post-translationally modified holo state, both of which conform to a four-helix bundle assembly. The structures exhibit the same general fold as the majority of known carrier protein structures, in spite of the complex biosynthetic role that PCP domains from the final non-ribosomal peptide synthetase module must play in glycopeptide antibiotic biosynthesis. These structures thus support the hypothesis that it is subtle rearrangements, rather than dramatic conformational changes, which govern carrier protein interactions and selectivity during non-ribosomal peptide synthesis. © 2015 Wiley Periodicals, Inc.

  15. CURRENT STATUS OF INTEGRITY ASSESSMENT BY SIPPING SYSTEM OF SPENT FUEL BUNDLES IRRADIATED IN CANDU REACTOR

    Directory of Open Access Journals (Sweden)

    JONG-YOUL PARK

    2014-12-01

    Full Text Available In terms of safety and the efficient management of spent fuel storage, detecting failed fuel is one of the most important tasks in a CANada Deuterium Uranium (CANDU reactor operation. It has been successfully demonstrated that in a CANDU reactor, on-power failed fuel detection and location systems, along with alarm area gamma monitors, can detect and locate defective and suspect fuel bundles before discharging them from the reactor to the spent fuel storage bay. In the reception bay, however, only visual inspection has been used to identify suspect bundles. Gaseous fission product and delayed neutron monitoring systems cannot precisely distinguish failed fuel elements from each fuel bundle. This study reports the use of a sipping system in a CANDU reactor for the integrity assessment of spent fuel bundles. The integrity assessment of spent fuel bundles using this sipping system has shown promise as a nondestructive test for detecting a defective fuel bundle in a CANDU reactor.

  16. Structural Causes of Right Bundle Branch Block—Time for a Closer Look?

    Science.gov (United States)

    Ker, James

    2010-01-01

    Right bundle branch block is an electrocardiographic phenomenon with specific criteria. Currently, two specific forms of right bundle branch block are acknowledged, a proximal and a distal variant. A vast array of pathologies can cause proximal, distal or even combined forms of right bundle branch block. In this study it is suggested that a third type of right bundle branch block exist: one caused by a subaortic muscular tendon in the left ventricle, leading to an increased velocity of conduction in the left ventricle, with a resultant “relative” right bundle branch block. It is concluded that it is necessary (and time) to take a closer look at endoventricular structures in the assessment of structural causes of right bundle branch block. PMID:20386615

  17. Hydrodynamic behavior of a bare rod bundle. [LMFBR

    Energy Technology Data Exchange (ETDEWEB)

    Bartzis, J.G.; Todreas, N.E.

    1977-06-01

    The temperature distribution within the rod bundle of a nuclear reactor is of major importance in nuclear reactor design. However temperature information presupposes knowledge of the hydrodynamic behavior of the coolant which is the most difficult part of the problem due to complexity of the turbulence phenomena. In the present work a 2-equation turbulence model--a strong candidate for analyzing actual three dimensional turbulent flows--has been used to predict fully developed flow of infinite bare rod bundle of various aspect ratios (P/D). The model has been modified to take into account anisotropic effects of eddy viscosity. Secondary flow calculations have been also performed although the model seems to be too rough to predict the secondary flow correctly. Heat transfer calculations have been performed to confirm the importance of anisotropic viscosity in temperature predictions. All numerical calculations for flow and heat have been performed by two computer codes based on the TEACH code. Experimental measurements of the distribution of axial velocity, turbulent axial velocity, turbulent kinetic energy and radial Reynolds stresses were performed in the developing and fully developed regions. A 2-channel Laser Doppler Anemometer working on the Reference mode with forward scattering was used to perform the measurements in a simulated interior subchannel of a triangular rod array with P/D = 1.124. Comparisons between the analytical results and the results of this experiment as well as other experimental data in rod bundle array available in literature are presented. The predictions are in good agreement with the results for the high Reynolds numbers.

  18. Restitution characteristics of His bundle and working myocardium in isolated rabbit hearts.

    Science.gov (United States)

    Huang, Shangwei; Wu, Liqun; Huang, Jian; Panitchob, Nuttanont; Hu, Nan; Ranjan, Ravi; Dosdall, Derek J

    2017-01-01

    The Purkinje system (PS) and the His bundle have been recently implicated as an important driver of the rapid activation rate after 1-2 minutes of ventricular fibrillation (VF). It is unknown whether activations during VF propagate through the His-Purkinje system to other portions of the the working myocardium (WM). Little is known about restitution characteristic differences between the His bundle and working myocardium at short cycle lengths. In this study, rabbit hearts (n = 9) were isolated, Langendorff-perfused, and electromechanically uncoupled with blebbistatin (10 μM). Pacing pulses were delivered directly to the His bundle. By using standard glass microelectrodes, action potentials duration (APD) from the His bundle and WM were obtained simultaneously over a wide range of stimulation cycle lengths (CL). The global F-test indicated that the two restitution curves of the His bundle and the WM are statistically significantly different (PHis bundle was significantly shorter than that of WM throughout the whole pacing course (PHis bundle vs. the WM were shorter for the His bundle (134.2±13.1ms vs. 148.3±13.3ms, PHis bundle than in WM (130.0±10.0 vs. 145.6±14.2ms, PHis bundle APD was significantly shorter than that of WM under both slow and rapid pacing rates, which suggest that there may be an excitable gap during VF and that the His bundle may conduct wavefronts from one bundle branch to the other at short cycle lengths and during VF.

  19. Non-properness of the functor of F-trivial bundles

    Indian Academy of Sciences (India)

    This is defined by assigning a Tannaka group to the Tannaka category of essentially finite vector bundles on. X [13, 14]. In these papers, Nori had made 2 conjectures: ... For any integer n > 1, we could define on Fn-trivial bundles on X as a .... for some line bundles Li, 1 ≤ i ≤ s on R with deg L1 > deg L2 > ··· > deg Ls.

  20. Recurrent extensive anterior myocardial infarction with left and right bundle branch block.

    Science.gov (United States)

    Jiang, Hexi; Chang, Qinghua; Zhang, Yingjie; Liu, Renguang

    2017-10-15

    The diagnosis of myocardial infarction with left bundle branch block is difficult. We report a case of 56-year-old man with old extensive anterior myocardial infarction and left bundle branch block (masked each other). The recurrent myocardial infarction indicated right bundle branch block and first-degree atrioventricular block, making a clear diagnosis of complicated and interesting ECG. © 2017 Wiley Periodicals, Inc.

  1. Harder Roads to Trek? Paradoxical Slowing of an Atrioventricular Reentrant Tachycardia With Contralateral Bundle Branch Block.

    Science.gov (United States)

    Divakara Menon, Syamkumar M; Ayati, Maryam; Healey, Jeff S

    2017-04-01

    Slowing of the tachycardia with increase in cycle length and increase in VA time with ipsilateral bundle branch block is a characteristic feature of accessory pathway mediated AVRT. Contralateral bundle branch block has no effect on the tachycardia as it is not a part of the tachycardia circuit. We present an interesting phenomenon in which contralateral bundle branch block resulted in tachycardia slowing in a case of WPW syndrome. © 2016 Wiley Periodicals, Inc.

  2. Left bundle-branch block with right axis deviation--a unique aberrancy during supraventricular tachycardia.

    Science.gov (United States)

    Lokhandwala, Yash; Panicker, Gopi Krishna; Shah, Mandar; Wellens, Hein J J

    2009-01-01

    A tachycardia with left bundle-branch block morphology and right axis deviation points to the diagnosis of ventricular tachycardia. Conversely, any supraventricular tachycardia with left bundle-branch block is typically associated with a normal or leftward QRS axis. We present the case of a 34-year-old man showing atrioventricular nodal reentrant tachycardia with left bundle-branch block/right axis deviation as an exception to this rule.

  3. PNA Peptide chimerae

    DEFF Research Database (Denmark)

    Koch, T.; Næsby, M.; Wittung, P.

    1995-01-01

    Radioactive labelling of PNA has been performed try linking a peptide segment to the PNA which is substrate for protein kinase A. The enzymatic phosphorylation proceeds in almost quantitative yields.......Radioactive labelling of PNA has been performed try linking a peptide segment to the PNA which is substrate for protein kinase A. The enzymatic phosphorylation proceeds in almost quantitative yields....

  4. GROUPS IN PEPTIDE SYNTHESIS

    African Journals Online (AJOL)

    In order to improve the synthesis of peptides with asparagine and glutamine residues, various carboxamide ... protecting groups in solid-phase peptide synthesis (SPPS). This method eliminates all .... to the filtrate, the solution was washed with three 9 mL portions of 5% aqueous citric acid, three 12 mL portions of 5% ...

  5. Intersection cohomology of moduli spaces of vector bundles over curves

    OpenAIRE

    Mozgovoy, Sergey; Reineke, Markus

    2015-01-01

    We compute the intersection cohomology of the moduli spaces $M(r,d)$ of semistable vector bundles of arbitrary rank $r$ and degree $d$ over a curve. To do this, we introduce new invariants, called Donaldson-Thomas invariants of a curve, which can be effectively computed by methods going back to Harder, Narasimhan, Desale and Ramanan. Our main result relates the Hodge-Euler polynomial of the intersection cohomology of $M(r,d)$ to the Donaldson-Thomas invariants. More generally, we introduce Do...

  6. Isolated Left Bundle Branch Block in a Toddler

    Directory of Open Access Journals (Sweden)

    Hitesh Agrawal

    2014-01-01

    Full Text Available Left bundle branch block (LBBB usually occurs as a postoperative complication from surgical correction of congenital heart disease and can be associated with hypertensive heart disease, coronary artery disease, myocarditis, and aortic valvular disease. Although isolated LBBB is a conduction abnormality found in some healthy adults, it has not been reported in pediatric population. We report a 2-year-old, healthy African American female who was incidentally discovered to have isolated LBBB that has persisted in a follow-up of 3 years.

  7. Isolated Left Bundle Branch Block in a Toddler

    Science.gov (United States)

    Zimmerman, Frank; Naheed, Zahra

    2014-01-01

    Left bundle branch block (LBBB) usually occurs as a postoperative complication from surgical correction of congenital heart disease and can be associated with hypertensive heart disease, coronary artery disease, myocarditis, and aortic valvular disease. Although isolated LBBB is a conduction abnormality found in some healthy adults, it has not been reported in pediatric population. We report a 2-year-old, healthy African American female who was incidentally discovered to have isolated LBBB that has persisted in a follow-up of 3 years. PMID:24963416

  8. Visualization of the medial forebrain bundle using diffusion tensor imaging

    Directory of Open Access Journals (Sweden)

    Ardian eHana

    2015-10-01

    Full Text Available Diffusion tensor imaging is a technique that enables physicians the portrayal of white matter tracts in vivo. We used this technique in order to depict the medial forebrain bundle in 15 consecutive patients between 2012 and 2015. Men and women of all ages were included. There were 6 women and 9 men. The mean age was 58,6 years (39-77. Nine patients were candidates for an eventual deep brain stimulation. Eight of them suffered from Parkinson`s disease and one had multiple sclerosis. The remaining 6 patients suffered from different lesions which were situated in the frontal lobe. These were 2 metastasis, 2 meningiomas, 1 cerebral bleeding and 1 glioblastoma. We used a 3DT1-sequence for the navigation. Furthermore T2- and DTI- sequences were performed. The FOV was 200 x 200 mm², slice thickness 2 mm, and an acquisition matrix of 96 x 96 yielding nearly isotropic voxels of 2 x 2 x 2 mm. 3-Tesla-MRI was carried out strictly axial using 32 gradient directions and one b0-image. We used Echo-Planar-Imaging (EPI and ASSET parallel imaging with an acceleration factor of 2. b-value was 800 s/mm². The maximal angle was 50°. Additional scanning time was less than 9 minutes. We were able to visualize the medial forebrain bundle in 12 of our patients bilaterally and in the remaining 3 patients we depicted the medial forebrain bundle on one side. It was the contralateral side of the lesion. These were 2 meningiomas and one metastasis. Portrayal of the medial forebrain bundle is possible for everyday routine for neurosurgical interventions. As part of the reward circuitry it might be of substantial importance for neurosurgeons during deep brain stimulation in patients with psychiatric disorders. Furthermore it might explain at a certain extent character changes in patients with lesions in the frontal lobe. Surgery in this part of the brain should always take the preservation of this white matter tract into account.

  9. A Parallel Section Functor for 2-Vector Bundles

    OpenAIRE

    Schweigert, Christoph; Woike, Lukas

    2017-01-01

    We associate to a 2-vector bundle over an essentially finite groupoid a 2-vector space of parallel sections, or, in representation theoretic terms, of higher invariants, which can be described as homotopy fixed points. Our main result is the extension of this assignment to a symmetric monoidal 2-functor $\\operatorname{Par} : \\mathbf{2VecBunGrpd} \\to \\mathbf{2Vect}$. It is defined on the symmetric monoidal bicategory $\\mathbf{2VecBunGrpd}$ whose morphisms arise from spans of groupoids in such ...

  10. Multidimensional Design of Anticancer Peptides

    OpenAIRE

    Lin YC; Lim YF; Russo E.; Schneider P; Bolliger L; Edenharter A; Altmann KH; Halin C; Hiss JA; Schneider G

    2015-01-01

    The computer assisted design and optimization of peptides with selective cancer cell killing activity was achieved through merging the features of anticancer peptides cell penetrating peptides and tumor homing peptides. Machine learning classifiers identified candidate peptides that possess the predicted properties. Starting from a template amino acid sequence peptide cytotoxicity against a range of cancer cell lines was systematically optimized while minimizing the effects on primary human e...

  11. Acylation of Therapeutic Peptides

    DEFF Research Database (Denmark)

    Trier, Sofie; Henriksen, Jonas Rosager; Jensen, Simon Bjerregaard

    Oral administration of therapeutic peptides could benefit millions of chronically ill people worldwide, through easier and less stigmatized therapy, and likely improve the long-term effects of currently widespread disease mismanagement. However, oral peptide delivery is a formidable task due......, but it is not widely studied in an oral context. As acylation furthermore increases interactions with the lipid membranes of mammalian cells, it offers several potential benefits for oral delivery of therapeutic peptides, and we hypothesize that tailoring the acylation may be used to optimize intestinal translocation...... to the harsh and selective gastrointestinal system, and development has lacked far behind injection therapy. Peptide acylation is a powerful tool to alter the pharmacokinetics, biophysical properties and chemical stability of injectable peptide drugs, primarily used to prolong blood circulation...

  12. Descriptors for antimicrobial peptides

    DEFF Research Database (Denmark)

    Jenssen, Håvard

    2011-01-01

    Introduction: A frightening increase in the number of isolated multidrug resistant bacterial strains linked to the decline in novel antimicrobial drugs entering the market is a great cause for concern. Cationic antimicrobial peptides (AMPs) have lately been introduced as a potential new class...... of antimicrobial drugs, and computational methods utilizing molecular descriptors can significantly accelerate the development of new peptide drug candidates. Areas covered: This paper gives a broad overview of peptide and amino-acid scale descriptors available for AMP modeling and highlights which...... examples of different peptide QSAR studies, this review highlights some of the missing links and illuminates some of the questions that would be interesting to challenge in a more systematic fashion. Expert opinion: Computer-aided peptide QSAR using molecular descriptors may provide the necessary edge...

  13. Bundle branch reentry: A rare mechanism of ventricular tachycardia in endomyocardial fibrosis, without ventricular dilation.

    Science.gov (United States)

    Prabhu, Mukund A; Prasad, B V Srinivas; Thajudeen, Anees; Namboodiri, Narayanan

    2016-09-01

    Bundle branch reentry as a mechanism of ventricular tachycardia (VT) in endomyocardial fibrosis (EMF) is not described. A 52-year-old woman with left ventricular (LV) EMF had VT needing cardioversion. She had mitral regurgitation and left bundle branch block, but no LV dilation or heart failure. During electrophysiological study, clinical VT could be easily induced, and it was confirmed to be bundle branch reentrant VT (BBRVT). She was treated with ablation of the right bundle branch. BBRVT can occur in EMF even without cardiac dilatation. Its recognition is important, as radiofrequency ablation can be curative. Copyright © 2016 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.

  14. Effects of reward bundling on male rats' preference for larger-later food rewards.

    Science.gov (United States)

    Stein, Jeffrey S; Smits, Rochelle R; Johnson, Patrick S; Liston, Kennan J; Madden, Gregory J

    2013-03-01

    In both humans and nonhumans, prior research demonstrates increased preference for larger-later over smaller-sooner rewards when rewards are bundled together in a series (i.e., when an operant choice produces multiple discrete reward deliveries, as opposed to only a single delivery). These findings can be predicted using a traditional hyperbolic delay-discounting model. The present study was designed to examine the parametric effects of the size of the reward bundle on larger-later reward preference in male rats. During a reward-bundling phase, rats were exposed to bundle-sizes of either 1 (i.e., no bundling), 3, or 9 rewards. Rats in the Bundle-size 9 group showed significantly greater larger-later reward preference across a range of delays (0-17.5 s) than rats in any other group, but no other significant differences in choice were observed between groups. In addition, when choice for unbundled rewards was assessed following the reward-bundling phase, rats in the Bundle-size 9 group showed a significant increase in larger-later reward preference (compared to a pre-test). Obtained data from the reward-bundling phase are compared to model-predicted data, and potential mechanisms of the observed increase in self-control for unbundled rewards are discussed. © Society for the Experimental Analysis of Behavior.

  15. Prostaglandins temporally regulate cytoplasmic actin bundle formation during Drosophila oogenesis

    Science.gov (United States)

    Spracklen, Andrew J.; Kelpsch, Daniel J.; Chen, Xiang; Spracklen, Cassandra N.; Tootle, Tina L.

    2014-01-01

    Prostaglandins (PGs)—lipid signals produced downstream of cyclooxygenase (COX) enzymes—regulate actin dynamics in cell culture and platelets, but their roles during development are largely unknown. Here we define a new role for Pxt, the Drosophila COX-like enzyme, in regulating the actin cytoskeleton—temporal restriction of actin remodeling during oogenesis. PGs are required for actin filament bundle formation during stage 10B (S10B). In addition, loss of Pxt results in extensive early actin remodeling, including actin filaments and aggregates, within the posterior nurse cells of S9 follicles; wild-type follicles exhibit similar structures at a low frequency. Hu li tai shao (Hts-RC) and Villin (Quail), an actin bundler, localize to all early actin structures, whereas Enabled (Ena), an actin elongation factor, preferentially localizes to those in pxt mutants. Reduced Ena levels strongly suppress early actin remodeling in pxt mutants. Furthermore, loss of Pxt results in reduced Ena localization to the sites of bundle formation during S10B. Together these data lead to a model in which PGs temporally regulate actin remodeling during Drosophila oogenesis by controlling Ena localization/activity, such that in S9, PG signaling inhibits, whereas at S10B, it promotes Ena-dependent actin remodeling. PMID:24284900

  16. [Intermittent bundle branch block: a clinical model for the study of electrophysiological phenomena].

    Science.gov (United States)

    Costantini, Marcello

    2014-01-01

    Disorders of intraventricular conduction (bundle branch block and hemiblock) are usually stable and remain unchanged irrespective of heart rate. Not infrequently, however, their appearance is related to the duration of the cardiac cycle, so that they appear and disappear with changes in heart rate. This may not even represent a pathological phenomenon, since sudden and consistent changes in cardiac cycle can result, even physiologically, in aberrant conduction. However, when a bundle branch block appears intermittently for simple and progressive increments, or even deceleration, of the sinus rate, this is related to a true bundle branch pathology, i.e. tachycardia-dependent (or phase 3) block or bradycardia-dependent (or phase 4) block, respectively. Phase 3 block is believed to express a pathological increase in the duration of the recovery period of the bundle branch. Phase 4 block was best explained on the basis of enhanced phase 4 depolarization of the bundle branch system, with inability of excitation if the cardiac cycle is particularly prolonged. The two types of block, phase 3 and phase 4, often coexist. An intraventricular conduction disturbance that appears during increasing heart rate for a phase 3 block is maintained, if frequency slows down, even for cycles greater than those that brought about its appearance. This is due to retrograde activation of the bundle branch blocked in the antegrade direction, with delay of its action potential inscription. Sometimes, in the presence of phase 3 bundle branch block, very early atrial ectopic beats are paradoxically conducted in the normal way (supernormal conduction). Perhaps, this phenomenon is related to a possible "climb over" of the injured zone of the bundle branch by the blocked impulses that arise beyond the injured area as subliminal impulses, exciting the healthy tissues if catches them during their phase of supernormal excitability. In the presence of intermittent bundle branch block, it is not

  17. Targeting diverse protein-protein interaction interfaces with α/β-peptides derived from the Z-domain scaffold.

    Science.gov (United States)

    Checco, James W; Kreitler, Dale F; Thomas, Nicole C; Belair, David G; Rettko, Nicholas J; Murphy, William L; Forest, Katrina T; Gellman, Samuel H

    2015-04-14

    Peptide-based agents derived from well-defined scaffolds offer an alternative to antibodies for selective and high-affinity recognition of large and topologically complex protein surfaces. Here, we describe a strategy for designing oligomers containing both α- and β-amino acid residues ("α/β-peptides") that mimic several peptides derived from the three-helix bundle "Z-domain" scaffold. We show that α/β-peptides derived from a Z-domain peptide targeting vascular endothelial growth factor (VEGF) can structurally and functionally mimic the binding surface of the parent peptide while exhibiting significantly decreased susceptibility to proteolysis. The tightest VEGF-binding α/β-peptide inhibits the VEGF165-induced proliferation of human umbilical vein endothelial cells. We demonstrate the versatility of this strategy by showing how principles underlying VEGF signaling inhibitors can be rapidly extended to produce Z-domain-mimetic α/β-peptides that bind to two other protein partners, IgG and tumor necrosis factor-α. Because well-established selection techniques can identify high-affinity Z-domain derivatives from large DNA-encoded libraries, our findings should enable the design of biostable α/β-peptides that bind tightly and specifically to diverse targets of biomedical interest. Such reagents would be useful for diagnostic and therapeutic applications.

  18. Numerical Investigation of Characteristic of Anisotropic Thermal Conductivity of Natural Fiber Bundle with Numbered Lumens

    Directory of Open Access Journals (Sweden)

    Guan-Yu Zheng

    2014-01-01

    Full Text Available Natural fiber bundle like hemp fiber bundle usually includes many small lumens embedded in solid region; thus, it can present lower thermal conduction than that of conventional fibers. In the paper, characteristic of anisotropic transverse thermal conductivity of unidirectional natural hemp fiber bundle was numerically studied to determine the dependence of overall thermal property of the fiber bundle on that of the solid region phase. In order to efficiently predict its thermal property, the fiber bundle was embedded into an imaginary matrix to form a unit composite cell consisting of the matrix and the fiber bundle. Equally, another unit composite cell including an equivalent solid fiber was established to present the homogenization of the fiber bundle. Next, finite element thermal analysis implemented by ABAQUS was conducted in the two established composite cells by applying proper thermal boundary conditions along the boundary of unit cell, and influences of the solid region phase and the equivalent solid fiber on the composites were investigated, respectively. Subsequently, an optional relationship of thermal conductivities of the natural fiber bundle and the solid region was obtained by curve fitting technique. Finally, numerical results from the obtained fitted curves were compared with the analytic Hasselman-Johnson’s results and others to verify the present numerical model.

  19. Characterization of midrib vascular bundles of selected medicinal species in Rubiaceae

    Science.gov (United States)

    Nurul-Syahirah, M.; Noraini, T.; Latiff, A.

    2016-11-01

    An anatomical study was carried out on mature leaves of five selected medicinal species of Rubiaceae from Peninsular Malaysia. The chosen medicinal species were Aidia densiflora, Aidia racemosa, Chasallia chartacea, Hedyotis auricularia and Ixora grandifolia. The objective of this study is to determine the taxonomic value of midrib anatomical characteristics. Leaves samples were collected from Taman Paku Pakis, Universiti Kebangsaan Malaysia, Bangi, Selangor and Kledang Saiong Forest Reserve, Perak, Malaysia. Leaves samples then were fixed in spirit and acetic acid (3:1), the midrib parts then were sectioned using sliding microtome, cleared using Clorox, stained in Safranin and Alcian blue, mounted in Euparal and were observed under light microscope. Findings in this study have shown all species have collateral bundles. The midrib vascular bundles characteristics that can be used as tool to differentiate between species or genus are vascular bundles system (opened or closed), shape and arrangement of main vascular bundles, presence of both additional and medullary vascular bundles, position of additional vascular bundles, shape of medullary vascular bundles, presence of sclerenchyma cells ensheathed the vascular bundles. As a conclusion, midrib anatomical characteristics can be used to identify and discriminate medicinal plants species studied in the Rubiaceae.

  20. Unpacking ecosystem service bundles : Towards predictive mapping of synergies and trade-offs between ecosystem services

    NARCIS (Netherlands)

    Spake, Rebecca; Lasseur, Rémy; Crouzat, Emilie; Bullock, James M.; Lavorel, Sandra; Parks, Katherine E.; Schaafsma, Marije; Bennett, Elena M.; Maes, Joachim; Mulligan, Mark; Mouchet, Maud; Peterson, Garry D.; Schulp, Catharina J.E.; Thuiller, Wilfried; Turner, Monica G.; Verburg, Peter H.; Eigenbrod, Felix

    2017-01-01

    Multiple ecosystem services (ES) can respond similarly to social and ecological factors to form bundles. Identifying key social-ecological variables and understanding how they co-vary to produce these consistent sets of ES may ultimately allow the prediction and modelling of ES bundles, and thus,

  1. Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase

    Directory of Open Access Journals (Sweden)

    Amayra Hernández-Vega

    2017-09-01

    Full Text Available Non-centrosomal microtubule bundles play important roles in cellular organization and function. Although many diverse proteins are known that can bundle microtubules, biochemical mechanisms by which cells could locally control the nucleation and formation of microtubule bundles are understudied. Here, we demonstrate that the concentration of tubulin into a condensed, liquid-like compartment composed of the unstructured neuronal protein tau is sufficient to nucleate microtubule bundles. We show that, under conditions of macro-molecular crowding, tau forms liquid-like drops. Tubulin partitions into these drops, efficiently increasing tubulin concentration and driving the nucleation of microtubules. These growing microtubules form bundles, which deform the drops while remaining enclosed by diffusible tau molecules exhibiting a liquid-like behavior. Our data suggest that condensed compartments of microtubule bundling proteins could promote the local formation of microtubule bundles in neurons by acting as non-centrosomal microtubule nucleation centers and that liquid-like tau encapsulation could provide both stability and plasticity to long axonal microtubule bundles.

  2. Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase.

    Science.gov (United States)

    Hernández-Vega, Amayra; Braun, Marcus; Scharrel, Lara; Jahnel, Marcus; Wegmann, Susanne; Hyman, Bradley T; Alberti, Simon; Diez, Stefan; Hyman, Anthony A

    2017-09-05

    Non-centrosomal microtubule bundles play important roles in cellular organization and function. Although many diverse proteins are known that can bundle microtubules, biochemical mechanisms by which cells could locally control the nucleation and formation of microtubule bundles are understudied. Here, we demonstrate that the concentration of tubulin into a condensed, liquid-like compartment composed of the unstructured neuronal protein tau is sufficient to nucleate microtubule bundles. We show that, under conditions of macro-molecular crowding, tau forms liquid-like drops. Tubulin partitions into these drops, efficiently increasing tubulin concentration and driving the nucleation of microtubules. These growing microtubules form bundles, which deform the drops while remaining enclosed by diffusible tau molecules exhibiting a liquid-like behavior. Our data suggest that condensed compartments of microtubule bundling proteins could promote the local formation of microtubule bundles in neurons by acting as non-centrosomal microtubule nucleation centers and that liquid-like tau encapsulation could provide both stability and plasticity to long axonal microtubule bundles. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  3. Adhering to a national surgical care bundle reduces the risk of surgical site infections

    NARCIS (Netherlands)

    Koek, Mayke B. G.; Hopmans, Titia E. M.; Soetens, Loes C.; Wille, Jan C.; Geerlings, Suzanne E.; Vos, Margreet C.; van Benthem, Birgit H. B.; de Greeff, Sabine C.

    2017-01-01

    In 2008, a bundle of care to prevent Surgical Site Infections (SSIs) was introduced in the Netherlands. The bundle consisted of four elements: antibiotic prophylaxis according to local guidelines, no hair removal, normothermia and 'hygiene discipline' in the operating room (i.e. number of door

  4. Adhering to a national surgical care bundle reduces the risk of surgical site infections

    NARCIS (Netherlands)

    Koek, M.B.G. (Mayke B. G.); Hopmans, T.E.M. (Titia E. M.); Soetens, L.C. (Loes C.); J.C. Wille (Jan); S.E. Geerlings (Suzanne); M.C. Vos (Margreet); B.H. van Benthem (Birgit); S.C. de Greeff (Sabine C.)

    2017-01-01

    textabstractBackground: In 2008, a bundle of care to prevent Surgical Site Infections (SSIs) was introduced in the Netherlands. The bundle consisted of four elements: antibiotic prophylaxis according to local guidelines, no hair removal, normothermia and ‘hygiene discipline’

  5. Left Bundle Branch Block and Complete Heart Block Complicating Inferior Myocardial Infarction.

    Science.gov (United States)

    Gruber, Jillian S; Stair, Brad; Aktas, Mehmet; Bravo-Jaimes, Katia

    2017-01-01

    Left bundle branch block following inferior myocardial infarction remains uncommon and scarcely reported in the literature. We describe a rare presentation of a 58-year-old male patient who developed left bundle branch block and third degree atrioventricular block after inferior myocardial infarction requiring permanent pacemaker placement. Pathophysiology, impact on mortality, and management options are discussed. © 2016 Wiley Periodicals, Inc.

  6. Changing axis deviation and intermittent right bundle branch block during acute myocardial infarction.

    Science.gov (United States)

    Patanè, Salvatore; Marte, Filippo; Sturiale, Mauro

    2011-03-03

    Dissimilar electrocardiographic patterns associated with right bundle branch block have been described. The prognosis of right bundle branch block in the absence of underlying cardiac disease is good but it may be poor in other cases, particularly coronary artery disease. Changing bundle branch block, new right bundle branch block, right bundle branch conduction disturbances have been reported in literature. Changing axis deviation has been reported alone or during acute myocardial infarction also associated with atrial fibrillation. Intermittent right axis deviation has been rarely reported in the presence of left bundle branch block also during atrial fibrillation and with acute myocardial infarction too. Isolated left posterior hemiblock is a very rare finding and transient right axis deviation associated with a left posterior hemiblock pattern has been also rarely described associated with acute myocardial infarction. We describe a case of changing axis deviation with intermittent right bundle branch block in a patient admitted with acute myocardial infarction. Also this case focuses attention on changing axis deviation and intermittent right bundle branch block during acute myocardial infarction. Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.

  7. To Be or Not To Be: The Existential Issue for National Governance Bundles

    NARCIS (Netherlands)

    Millar-Schijf, Carla C.J.M.

    2014-01-01

    Research Question/Issue The article addresses the issue of whether governance bundles which include both formal and informal governance mechanisms should be classified and compared on the basis of national identity. Research Findings/Insights The governance bundle affecting each firm has formal

  8. On the non-existence of orthogonal instanton bundles on P^{2n+1}

    Directory of Open Access Journals (Sweden)

    Łucja Farnik

    2009-11-01

    Full Text Available In this paper we prove that there do not exist orthogonal instanton bundles on P^{2n+1} . In order to demonstrate this fact, we propose a new way of representing the invariant, introduced by L. Costa and G. Ottaviani, related to a rank 2n instanton bundle on P^{2n+1}.

  9. Engineering the bundled glass column: From the design concept to full-scale experimental testing

    NARCIS (Netherlands)

    Oikonomopoulou, F.; Bristogianni, T.; Veer, F.A.; Nijsse, R.

    This article gives an overview of the research conducted by the authors from the design concept to the engineering and full-scale testing of the bundled glass column. Consisting of adhesively bonded solid glass rods, the bundled column is a promising solution for transparent compressive members. To

  10. Implementing a Sepsis Resuscitation Bundle Improved Clinical Outcome: A Before-and-After Study

    Directory of Open Access Journals (Sweden)

    Jeongmin Kim

    2014-11-01

    CONCLUSIONS: Repeated education led by a multidisciplinary team and interdisciplinary communication improved the compliance rate of the 6-h resuscitation bundle in severe sepsis and septic shock patients. Compliance with the sepsis resuscitation bundle was associated with improved 28-day mortality in the study population.

  11. "The Purpose of This Study Is to": Connecting Lexical Bundles and Moves in Research Article Introductions

    Science.gov (United States)

    Cortes, Viviana

    2013-01-01

    This article presents a group of lexical bundles identified in a corpus of research article introductions as the first step in the analysis of these expressions in the different sections of the research article. A one-million word corpus of research article introductions from various disciplines was compiled and the lexical bundles identified in…

  12. Constructed microhabitat bundles for sampling fishes and crayfishes in coastal plain streams

    Science.gov (United States)

    Melvin L. Warren; A.L. Sheldon; W.R. Haag

    2009-01-01

    We investigated fish and crayfish use of standardized, constructed microhabitats (bundles) in three northern Mississippi streams. Cypress Creek and the Little Tallahatchie Canal were channelized and incised and had little woody cover; Puskus Creek was unchannelized and unincised and had abundant woody cover. We constructed three types of bundles (cane, leaf, and string...

  13. A simulation study on the adsorption properties of linear alkanes on closed nanotube bundles

    NARCIS (Netherlands)

    Cannon, J.J.; Vlugt, T.J.H.; Dubbeldam, D.; Maruyama, S.; Shiomi, J.

    2012-01-01

    Adsorption onto carbon nanotube bundles may find use in various applications such as gas pre-concentration and separation, and as a result it is of great interest to study the adsorption properties of such bundles. The adsorption of linear alkanes, with their systematic variation through chain

  14. Right bundle branch block with revelation of changing axis deviation at the end of atrial fibrillation.

    Science.gov (United States)

    Patanè, Salvatore; Marte, Filippo; Sturiale, Mauro

    2009-11-12

    Changing axis deviation has been reported also during atrial fibrillation or atrial flutter. Changing axis deviation has been also reported during acute myocardial infarction associated with atrial fibrillation too or at the end of atrial fibrillation during acute myocardial infarction. Left bundle branch block is usually associated with normal or left axis deviation. Rarely the ECG shows a left bundle branch block with changing QRS morphology and changing axis deviation. There are several possible explanations for the intermittent shift in the QRS axis in the presence of complete left bundle branch block. The most plausible explanation is the coexistence of left posterior hemiblock and predivisional left bundle branch block. Intermittent right axis deviation has been rarely reported in the presence of left bundle branch block also during atrial fibrillation and with acute myocardial infarction too. Isolated left posterior hemiblock is a very rare finding and transient right axis deviation associated with a left posterior hemiblock pattern has been also rarely described associated with acute myocardial infarction. Changing axis deviation with changing bundle branch block and new-onset of atrial fibrillation during acute myocardial infarction has been also reported. Changing axis deviation with intermittent right bundle branch block in a patient admitted with acute myocardial infarction has been also described. We present a case of a right bundle branch block with revelation of changing axis deviation at the end of atrial fibrillation in a 68-year-old Italian man.

  15. Atrial fibrillation with intermittent right axis deviation in the presence of complete left bundle branch block.

    Science.gov (United States)

    Patanè, Salvatore; Marte, Filippo; Di Bella, Gianluca; Chiribiri, Amedeo

    2008-09-16

    Left bundle branch block is usually associated with normal or left axis deviation. Rarely the ecg shows an LBBB with changing QRS morphology and changing axis deviation. We describe a case of atrial fibrillation with intermittent right axis deviation in the presence of complete left bundle branch block in an 84-year-old Italian woman in the Cardiology Unit.

  16. The determinant bundle on the moduli space of stable triples over a ...

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    bundles over a Riemann surface and also on the existence of a special metric on a stable triple established in [BG]. Here is a brief outline of the contents of the paper. In §2, we recall the basic notions about holomorphic triples, their stability, and their moduli spaces. In §3, we construct a natural holomorphic line bundle L on ...

  17. Vector bundles with a fixed determinant on an irreducible nodal curve

    Indian Academy of Sciences (India)

    sheaves with a fixed determinant in the moduli space of torsion-free sheaves on Y. The relation to Seshadri–Nagaraj conjecture is studied. Keywords. Nodal curves; torsion-free sheaves; fixed determinant. 1. Introduction. Generalized parabolic vector bundles (GPBs) on a smooth curve X are vector bundles on. X together ...

  18. GPU acceleration of the stochastic grid bundling method for early-exercise options

    NARCIS (Netherlands)

    A. Leitao Rodriguez (Álvaro); C.W. Oosterlee (Cornelis)

    2015-01-01

    htmlabstractIn this work, a parallel graphics processing units (GPU) version of the Monte Carlo stochastic grid bundling method (SGBM) for pricing multi-dimensional early-exercise options is presented. To extend the method’s applicability, the problem dimensions and the number of bundles will be

  19. Unwrapping the Bundle: An Examination of Research Libraries and the "Big Deal"

    Science.gov (United States)

    Strieb, Karla L.; Blixrud, Julia C.

    2014-01-01

    This study presents and analyzes the findings of a 2012 survey of member libraries belonging to the Association of Research Libraries (ARL) about publishers' large journal bundles and compares the results to earlier surveys. The data illuminate five research questions: market penetration, journal bundle construction, collection format shifts,…

  20. Insulin C-peptide

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/003701.htm Insulin C-peptide test To use the sharing features ... a product that is created when the hormone insulin is produced and released into the body. The ...

  1. Tumor penetrating peptides

    Directory of Open Access Journals (Sweden)

    Tambet eTeesalu

    2013-08-01

    Full Text Available Tumor-homing peptides can be used to deliver drugs into tumors. Phage library screening in live mice has recently identified homing peptides that specifically recognize the endothelium of tumor vessels, extravasate, and penetrate deep into the extravascular tumor tissue. The prototypic peptide of this class, iRGD (CRGDKGPDC, contains the integrin-binding RGD motif. RGD mediates tumor homing through binding to αv integrins, which are selectively expressed on various cells in tumors, including tumor endothelial cells. The tumor-penetrating properties of iRGD are mediated by a second sequence motif, R/KXXR/K. This C-end Rule (or CendR motif is active only when the second basic residue is exposed at the C-terminus of the peptide. Proteolytic processing of iRGD in tumors activates the cryptic CendR motif, which then binds to neuropilin-1 activating an endocytic bulk transport pathway through tumor tissue. Phage screening has also yielded tumor-penetrating peptides that function like iRGD in activating the CendR pathway, but bind to a different primary receptor. Moreover, novel tumor-homing peptides can be constructed from tumor-homing motifs, CendR elements and protease cleavage sites. Pathologies other than tumors can be targeted with tissue-penetrating peptides, and the primary receptor can also be a vascular zip code of a normal tissue. The CendR technology provides a solution to a major problem in tumor therapy, poor penetration of drugs into tumors. The tumor-penetrating peptides are capable of taking a payload deep into tumor tissue in mice, and they also penetrate into human tumors ex vivo. Targeting with these peptides specifically increases the accumulation in tumors of a variety of drugs and contrast agents, such as doxorubicin, antibodies and nanoparticle-based compounds. Remarkably the drug to be targeted does not have to be coupled to the peptide; the bulk transport system activated by the peptide sweeps along any compound that is

  2. Innovative Therapeutics: Designer Natriuretic Peptides.

    Science.gov (United States)

    Meems, Laura M G; Burnett, John C

    2016-12-01

    Endogenous natriuretic peptides serve as potent activators of particulate guanylyl cyclase receptors and the second messenger cGMP. Natriuretic peptides are essential in maintenance of volume homeostasis, and can be of myocardial, renal and endothelial origin. Advances in peptide engineering have permitted the ability to pursue highly innovative drug discovery strategies. This has resulted in designer natriuretic peptides that go beyond native peptides in efficacy, specificity, and resistance to enzymatic degradation. Together with recent improvements in peptide delivery systems, which have improved bioavailability, further advances in this field have been made. Therefore, designer natriuretic peptides with pleotropic actions together with strategies of chronic delivery have provided an unparalleled opportunity for the treatment of cardiovascular disease. In this review, we report the conceptual framework of peptide engineering of the natriuretic peptides that resulted in designer peptides for cardiovascular disease. We specifically provide an update on those currently in clinical trials for heart failure and hypertension, which include Cenderitide, ANX042 and ZD100.

  3. Artificial di-iron proteins: solution characterization of four helix bundles containing two distinct types of inter-helical loops.

    Science.gov (United States)

    Maglio, Ornella; Nastri, Flavia; Calhoun, Jennifer R; Lahr, Stephen; Wade, Herschel; Pavone, Vincenzo; DeGrado, William F; Lombardi, Angela

    2005-08-01

    Peptide-based models have an enormous impact for the development of metalloprotein models, as they seem appropriate candidates to mimic both the structural characteristics and reactivity of the natural systems. Through the de novo design of four-helix bundles, we developed the DF (Due Ferri) family of artificial proteins, as models of di-iron and di-manganese metalloproteins. The goal of our research is to elucidate how the electrostatic environment, polarity and solvent accessibility of the metal-binding site, influence the functional properties of di-iron proteins. The first two subsets of the DF protein family, DF1 and DF2, consist of two non-covalently associated helix-loop-helix motifs, which bind the di-metal cofactor near the center of the structure. The DF2 subset was designed to improve the properties of DF1: DF2 and DF2t have several changes in their sequences to improve solubility and metal ion access, as well as a change in the loop connecting the two helices. In order to evaluate how these changes affect the overall structure of the model proteins, we solved the NMR structures of the di-Zn(II) complexes of DF2 and DF2t, and compared these structures with those recently obtained from X-ray crystallography. Further, we examined the thermodynamic consequences associated with the mutations, by measuring the stability of DF2t in the presence of different metal ions, and comparing the results with the data already obtained for DF2. Taken together, analysis of all the data showed the importance of the turn conformation in the design and stability of four-helix bundle.

  4. Peptide Nucleic Acids

    DEFF Research Database (Denmark)

    2004-01-01

    A novel class of compounds known as peptide nucleic acids, bind complementary DNA and RNA strands, and generally do so more strongly than the corresponding DNA or RNA strands while exhibiting increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a...... a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases, including 2,6-diaminopurine, attached to a polyamide backbone, and contain alkyl amine side chains....

  5. Single and two-phase flow pressure drop for CANFLEX bundle

    Energy Technology Data Exchange (ETDEWEB)

    Park, Joo Hwan; Jun, Ji Su; Suk, Ho Chun [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of); Dimmick, G. R.; Bullock, D. E. [Atomic Energy of Canada Limited, Ontario (Canada)

    1998-12-31

    Friction factor and two-phase flow frictional multiplier for a CANFLEX bundle are newly developed and presented in this paper. CANFLEX as a 43-element fuel bundle has been developed jointly by AECL/KAERI to provide greater operational flexibility for CANDU reactor operators and designers. Friction factor and two-phase flow frictional multiplier have been developed by using the experimental data of pressure drops obtained from two series of Freon-134a (R-134a) CHF tests with a string of simulated CANFLEX bundles in a single phase and a two-phase flow conditions. The friction factor for a CANFLEX bundle is found to be about 20% higher than that of Blasius for a smooth circular pipe. The pressure drop predicted by using the new correlations of friction factor and two-phase frictional multiplier are well agreed with the experimental pressure drop data of CANFLEX bundle within {+-} 5% error. 11 refs., 5 figs. (Author)

  6. Biosynthesis of cardiac natriuretic peptides

    DEFF Research Database (Denmark)

    Goetze, Jens Peter

    2010-01-01

    peptides has only been elucidated during the last decade. The cellular synthesis including amino acid modifications and proteolytic cleavages has proven considerably more complex than initially perceived. Consequently, the elimination phase of the peptide products in circulation is not yet well...... competent endocrine cells. The structurally related atrial natriuretic peptide will be mentioned where appropriate, whereas C-type natriuretic peptide will not be considered as a cardiac peptide of relevance in mammalian physiology....

  7. Peptides at Membrane Surfaces and their Role in the Origin of Life

    Science.gov (United States)

    Pohorille, Andrew; Wilson, Michael A.; DeVincenzi, D. (Technical Monitor)

    2002-01-01

    All ancestors of contemporary cells (protocells) had to transport ions and organic matter across membranous walls, capture and utilize energy and transduce environmental signals. In modern organisms, all these functions are preformed by membrane proteins. We make the parsimonious assumption that in the protobiological milieu the same functions were carried out by their simple analogs - peptides. This, however, required that simple peptides could self-organize into ordered, functional structures. In a series of detailed, molecular-level computer simulations we demonstrated how this is possible. One example is the peptide (LSLLLSL)3 which forms a trameric bundle capable of transporting protons across membranes. Another example is the transmembrane pore of the influenza M2 protein. This aggregate of four identical alpha-helices, each built of 25 amino acids, forms an efficient and selective voltage-gated proton channel. Our simulations explain the gating mechanism in this channel. The channel can be re-engineered into a simple proton pump.

  8. A GRAPH BASED BUNDLE ADJUSTMENT FOR INS-CAMERA CALIBRATION

    Directory of Open Access Journals (Sweden)

    D. Bender

    2013-08-01

    Full Text Available In this paper, we present a graph based approach for performing the system calibration of a sensor suite containing a fixed mounted camera and an inertial navigation system. The aim of the presented work is to obtain accurate direct georeferencing of camera images collected with small unmanned aerial systems. Prerequisite for using the pose measurements from the inertial navigation system as exterior orientation for the camera is the knowledge of the static offsets between these devices. Furthermore, the intrinsic parameters of the camera obtained in a laboratory tend to deviate slightly from the values during flights. This induces an in-flight calibration of the intrinsic camera parameters in addition to the mounting offsets between the two devices. The optimization of these values can be done by introducing them as parameters into a bundle adjustment process. We show how to solve this by exploiting a graph optimization framework, which is designed for the least square optimization of general error functions.

  9. a Graph Based Bundle Adjustment for Ins-Camera Calibration

    Science.gov (United States)

    Bender, D.; Schikora, M.; Sturm, J.; Cremers, D.

    2013-08-01

    In this paper, we present a graph based approach for performing the system calibration of a sensor suite containing a fixed mounted camera and an inertial navigation system. The aim of the presented work is to obtain accurate direct georeferencing of camera images collected with small unmanned aerial systems. Prerequisite for using the pose measurements from the inertial navigation system as exterior orientation for the camera is the knowledge of the static offsets between these devices. Furthermore, the intrinsic parameters of the camera obtained in a laboratory tend to deviate slightly from the values during flights. This induces an in-flight calibration of the intrinsic camera parameters in addition to the mounting offsets between the two devices. The optimization of these values can be done by introducing them as parameters into a bundle adjustment process. We show how to solve this by exploiting a graph optimization framework, which is designed for the least square optimization of general error functions.

  10. Sachs equations for light bundles in a cold plasma

    Science.gov (United States)

    Schulze-Koops, Karen; Perlick, Volker; Schwarz, Dominik J.

    2017-11-01

    We study the propagation of light bundles in non-empty spacetime, as most of the Universe is filled by baryonic matter in the form of a (dilute) plasma. Here we restrict to the case of a cold (i.e. pressureless) and non-magnetised plasma. Then the influence of the medium on the light rays is encoded in the spacetime dependent plasma frequency. Our result for a general spacetime generalises the Sachs equations to the case of a cold plasma Universe. We find that the reciprocity law (Etherington theorem), the relation that connects area distance with luminosity distance, is modified. Einstein’s field equation is not used, i.e. our results apply independently of whether or not the plasma is self-gravitating. As an example, our findings are applied to a homogeneous plasma in a Robertson-Walker spacetime. We find small modifications of the cosmological redshift of frequencies and of the Hubble law.

  11. Anticommons, the Coase Theorem and the problem of bundling inefficiency

    Directory of Open Access Journals (Sweden)

    Ivan Major

    2016-02-01

    Full Text Available The Coase theorem is most often formulated in terms of bi-lateral monopoly, for instance between a polluting factory and an affected neighbour.  Instead, we introduce multiple affected neighbours and the concept of anticommons, in which autonomous actors with separate yet necessarily complementary inputs each has the right to deny but not to permit use.  Once we posit multiple owners possessing complementary rights, strategically maximizing against each other as well as against the actor who wishes to purchase a portion of that right, the outcome is neither efficient nor invariant.  Our finding, based on non-cooperative game theory, is sustained even under the restrictive Coase assumptions regarding complete information, perfect rationality, and zero transaction costs. The implication is that suboptimal bundling agreements in cases of multiple stakeholders is not the mere product of market imperfection, but instead is a systematic result.

  12. Rare Manifestation of Digoxin Toxicity: Right Bundle Branch Block

    Science.gov (United States)

    Gill, Dalvir; Zaidi, Samana

    2016-01-01

    A 76-year-old female, with medical history significant for systolic congestive heart failure, who presented to the emergency department with lethargy and abdominal pain with diarrhea for the past 3 weeks. Due to hypotension, the patient received multiple boluses of isotonic saline and was started on norepinephrine. Laboratories were significant for severe digoxin toxicity (29 ng/mL), in setting of acute kidney injury. Electrocardiogram (EKG) revealed a new right bundle branch block (RBBB). She was given Digibind and her repeat digoxin level was 20 ng/mL. Repeat EKG showed resolved RBBB. This case identifies that patients with digoxin toxicity are at risk for RBBB. This is a rare finding and is not commonly recognized. Emergency medicine physicians are often the first to encounter patients with digoxin toxicity and need to be aware of such EKG findings. PMID:28104974

  13. Intermittent left bundle branch block caused by coronary vasospasm

    Science.gov (United States)

    Alhaji, Mohammad

    2013-01-01

    Intermittent left bundle branch block (LBBB) has been reported in the literature following certain conditions such as cardiac blunt trauma, myocardial infarction (MI) or exercise induced LBBB. In the majority of cases, the patients usually have underlying coronary arteries disease. LBBB often prevents the electrocardiographic diagnosis of acute MI; therefore, new LBBB in the setting of chest pain is usually treated as transmural MI. We describe a case of patient who presented with intermittent LBBB associated with chest pain, and subsequently the patient was taken to the catheterization laboratory for emergency coronary angiogram, which revealed 80% spasm in left anterior descending artery, which was totally relieved by nitroglycerin infusion. No other significant CAD was noted. PMID:23930243

  14. Modified Einstein and Finsler Like Theories on Tangent Lorentz Bundles

    CERN Document Server

    Stavrinos, Panayiotis; Vacaru, Sergiu I.

    2014-01-01

    We study modifications of general relativity, GR, with nonlinear dispersion relations which can be geometrized on tangent Lorentz bundles. Such modified gravity theories, MGTs, can be modeled by gravitational Lagrange density functionals $f(\\mathbf{R},\\mathbf{T},F)$ with generalized/ modified scalar curvature $\\mathbf{R}$, trace of matter field tensors $\\mathbf{T}$ and modified Finsler like generating function $F$. In particular, there are defined extensions of GR with extra dimensional "velocity/ momentum" coordinates. For four dimensional models, we prove that it is possible to decouple and integrate in very general forms the gravitational fields for $f(\\mathbf{R},\\mathbf{T},F)$--modified gravity using nonholonomic 2+2 splitting and nonholonomic Finsler like variables $F$. We study the modified motion and Newtonian limits of massive test particles on nonlinear geodesics approximated with effective extra forces orthogonal to the four-velocity. We compute the constraints on the magnitude of extra-acceleration...

  15. Design of electric control system for automatic vegetable bundling machine

    Science.gov (United States)

    Bao, Yan

    2017-06-01

    A design can meet the requirements of automatic bale food structure and has the advantages of simple circuit, and the volume is easy to enhance the electric control system of machine carrying bunch of dishes and low cost. The bundle of vegetable machine should meet the sensor to detect and control, in order to meet the control requirements; binding force can be adjusted by the button to achieve; strapping speed also can be adjusted, by the keys to set; sensors and mechanical line connection, convenient operation; can be directly connected with the plug, the 220V power supply can be connected to a power source; if, can work, by the transmission signal sensor, MCU to control the motor, drive and control procedures for small motor. The working principle of LED control circuit and temperature control circuit is described. The design of electric control system of automatic dish machine.

  16. Spent fuel bundle counter sequence error manual - BRUCE NGS

    Energy Technology Data Exchange (ETDEWEB)

    Nicholson, L.E

    1992-03-20

    The Spent Fuel Bundle Counter (SFBC) is used to count the number and type of spent fuel transfers that occur into or out of controlled areas at CANDU reactor sites. However if the transfers are executed in a non-standard manner or the SFBC is malfunctioning, the transfers are recorded as sequence errors. Each sequence error message typically contains adequate information to determine the cause of the message. This manual provides a guide to interpret the various sequence error messages that can occur and suggests probable cause or causes of the sequence errors. Each likely sequence error is presented on a 'card' in Appendix A. Note that it would be impractical to generate a sequence error card file with entries for all possible combinations of faults. Therefore the card file contains sequences with only one fault at a time. Some exceptions have been included however where experience has indicated that several faults can occur simultaneously.

  17. Spent fuel bundle counter sequence error manual - DARLINGTON NGS

    Energy Technology Data Exchange (ETDEWEB)

    Nicholson, L.E

    1992-03-25

    The Spent Fuel Bundle Counter (SFBC) is used to count the number and type of spent fuel transfers that occur into or out of controlled areas at CANDU reactor sites. However if the transfers are executed in a non-standard manner or the SFBC is malfunctioning, the transfers are recorded as sequence errors. Each sequence error message typically contains adequate information to determine the cause of the message. This manual provides a guide to interpret the various sequence error messages that can occur and suggests probable cause or causes of the sequence errors. Each likely sequence error is presented on a 'card' in Appendix A. Note that it would be impractical to generate a sequence error card file with entries for all possible combinations of faults. Therefore the card file contains sequences with only one fault at a time. Some exceptions have been included however where experience has indicated that several faults can occur simultaneously.

  18. Ion-irradiation-induced defects in bundles of carbon nanotubes

    CERN Document Server

    Salonen, E; Nordlund, K

    2002-01-01

    We study the structure and formation yields of atomic-scale defects produced by low-dose Ar ion irradiation in bundles of single-wall carbon nanotubes. For this, we employ empirical potential molecular dynamics and simulate ion impact events over an energy range of 100-1000 eV. We show that the most common defects produced at all energies are vacancies on nanotube walls, which at low temperatures are metastable but long-lived defects. We further calculate the spatial distribution of the defects, which proved to be highly non-uniform. We also show that ion irradiation gives rise to the formations of inter-tube covalent bonds mediated by carbon recoils and nanotube lattice distortions due to dangling bond saturation. The number of inter-tube links, as well as the overall damage, linearly grows with the energy of incident ions.

  19. Ultrasonographic evaluation of displaced neurovascular bundle in Dupuytren disease.

    Science.gov (United States)

    Uehara, Kosuke; Miura, Toshiki; Morizaki, Yutaka; Miyamoto, Hideaki; Ohe, Takashi; Tanaka, Sakae

    2013-01-01

    Neurovascular injury is a serious complication after surgery for Dupuytren disease. The purpose of this study was to evaluate the relationship between the cord and the neurovascular bundle ultrasonographically. We included 22 healthy volunteers and 14 Dupuytren disease patients (25 fingers) in this study. We evaluated the cord and the digital artery with high-resolution ultrasound. We first investigated the effect of the angle of metacarpophalangeal joint on the position of the radial and ulnar digital arteries in volunteers without evidence of Dupuytren disease. We compared 3 parameters of the radial and ulnar digital arteries, including differences in depth, differences in lateral shift, and the shape of the cross-section of the artery, between volunteers and patients with Dupuytren disease. None of these parameters changed with flexion of the metacarpophalangeal joint of 0°, 30°, and 60°. Digital arteries and cords could be identified ultrasonographically in all patients, and we confirmed ultrasonographic findings by operative findings in 13 fingers. We classified the fingers into 3 subgroups based on the ultrasonographic findings: type A (n = 13), in which the cord was above the artery; type B (n = 5), in which the cord was below the artery; and type C (n = 7), in which the cord was located between the radial and ulnar digital arteries. Types A, B, and C corresponded to natatory cord/abductor digiti minimi cord, spiral cord, and central cord, respectively. Comparisons among volunteers and patient subgroups showed that the difference in depth in type B patients was significantly larger than that of the other groups. When we set the cutoff point of the difference in depth to 3 mm, sensitivity and specificity to detect the spiral cord were 80% and 76%, respectively. The relationship between the neurovascular bundle and the type of Dupuytren disease cord can be evaluated by high-resolution ultrasound. Diagnostic III. Copyright © 2013 American Society for

  20. Critical Power in 7-Rod Tight Lattice Bundle

    Science.gov (United States)

    Liu, Wei; Kureta, Masatoshi; Akimoto, Hajime

    The Reduced-Moderation Water Reactor (RMWR) has recently becomes of great concern. The RMWR is expected to promote the effective utilization of uranium recourse. The RMWR is based on water-cooled reactor technology, with achieved under lower core water volume and water flow rate. In comparison with the current light water reactors whose water-to-fuel volume ratio is about 2-3, in the RMWR, this value is reduced to less than 0.5. Thereby, there is a need to research its cooling characteristics. Experimental research on critical power in tight lattice bundle that simulates the RMWR has been carried out in Japan Atomic Energy Research Institute (JAERI). The bundle consists one center rod and six peripheral rods. The 7 rods are arranged on a 14.3mm equilateral triangular pitch. Each rod is 13mm in outside diameter. An axial 12-step power distribution is employed to simulate the complicate heating condition in RMWR. Experiments are carried out under G=100-1400kg/m2s, Pex=2-8.5MPa. Effects of mass velocity, inlet temperature, pressure, radial peaking factor and axial peaking factor on critical power and critical quality are discussed. Compared with axial uniform heating condition, the axial non-uniform heating condition causes an obvious decrease in critical quality. Arai correlation, which is the only correlation that has been optimized for tight lattice condition, is verified with the present experimental data. The correlation is found to be able to give reasonable prediction only around RMWR nominal operating condition.

  1. Anatomical Double-Bundle Coracoclavicular Reconstruction in Chronic Acromioclavicular Dislocation.

    Science.gov (United States)

    Lee, Sang Ki; Song, Dae Geon; Choy, Won Sik

    2015-08-01

    The purpose of this study was to evaluate the clinical and radiological outcomes of anatomical double-bundle coracoclavicular (CC) reconstruction using the coracoacromial (CA) ligament and the conjoined tendon for the treatment of chronic acromioclavicular (AC) joint dislocation. A retrospective evaluation was performed on 18 patients who underwent an anatomical CC reconstruction using the CA ligament and the conjoined tendon for chronic AC joint dislocation. Patients were treated surgically between April 2007 and January 2012. Mean follow-up was 35.3 months (range, 24-49 months). All patients were evaluated for functional outcomes using the modified University of California, Los Angeles (UCLA) shoulder rating scale for chronic AC injury and the Constant-Murley shoulder outcome score. Range of motion and shoulder and elbow strength were also measured. Plain radiographs were taken to evaluate reduction status and CC distance. Mean modified UCLA shoulder rating scale at final follow-up was 18.1 points (range, 13-20 points). No significant difference in mean Constant-Murley scores existed between the injured and contralateral shoulders (P=.26). At final follow-up, 15 (83.3%) patients had well-maintained reduction and 2 (11.1%) patients had a partial loss of reduction. One other patient had a complete loss of reduction due to a postoperative fall. The CC distance was not significantly different between the injured and contralateral shoulders in the immediate postoperative period (P=.46) or at final follow-up (P=.14). One superficial wound infection occurred and was treated with routine wound care. An anatomical double-bundle CC reconstruction using the CA ligament and the conjoined tendon for the treatment of chronic AC joint dislocation is a reliable surgical method with good results. Copyright 2015, SLACK Incorporated.

  2. The severe sepsis bundles as processes of care: a meta-analysis.

    Science.gov (United States)

    Chamberlain, Diane J; Willis, Eileen M; Bersten, Andrew B

    2011-11-01

    The use of the sepsis bundles in patients with severe sepsis and septic shock has been controversial in the last decade. Clinical studies have reported beneficial, as well as negative results. We conducted a meta-analysis to assess the clinical evidence and to evaluate survival effects. Database searches (2004-current) of Medline, CINAHL, Pubmed, Cochrane, Scopus and Google scholar databases which covered full publications, abstracts from conferences and digital thesis were performed using the search terms sepsis, septic shock and/or bundles, processes of care, guidelines, early goal directed therapy, resuscitation. From 253 identified studies, 21 sepsis bundle original studies were selected and included 23,438 patients. The Resuscitation 6 hour Bundle pooled analysis (1819 patients) achieved the greatest survival benefit (odds ratio (OR) 2.124, 95% CI 1.701-2.651, p<0.000) with the Management 24 hour Bundle pooled analysis the lowest survival benefit (16,521 patients) (OR 1.646, 95% CI 1.036-2.614, p<0.035). Both bundles together (Complete Bundle) achieved a combined survival benefit (OR 1.744, 95% CI 1.421-2.141, p<0.000). ScvO2 and blood glucose components were analysed individually to assess their contribution to survival. The Resuscitation 6 hour bundle in the context of the patient population at hand is unlikely to do harm and is yet to be established in primary research in Australia. The Management 24 hour Bundle could not establish a strong enough survival benefit above current routine practice. The sepsis guidelines and bundles have demanded more credible process measurements and debate to induce positive changes in the intervention and treatment care of patients with severe sepsis. Copyright © 2011 Australian College of Critical Care Nurses Ltd. Published by Elsevier Ltd. All rights reserved.

  3. Evidence for two populations of hair bundles in the sea anemone, Nematostella vectensis.

    Science.gov (United States)

    Menard, Shelcie S; Watson, Glen M

    2017-06-01

    Cytochalasin D (CD) was employed to disrupt F-actin within stereocilia of anemone hair bundles. CD treatment decreases the abundance of hair bundles (by 85%) while significantly impairing predation. The remaining hair bundles are 'CD-resistant.' Surprisingly, the morphology and F-actin content of resistant hair bundles are comparable to those of untreated controls. However, the resistant hair bundles fail to respond normally to the N-acetylated sugar, NANA, by elongating. Instead, they remain at resting length. Immediately after CD treatment, when only CD-resistant hair bundles are present, nematocyst discharge is normal into targets touched to tentacles in the absence of vibrations (i.e., baseline) but fails to increase normally in the presence of nearby vibrations at 56Hz, a key frequency. After CD treatment, the abundance of hair bundles recovers to control levels within three hours. At 2h after CD treatment, when CD-resistant and CD-sensitive hair bundles are both present, but a full-recovery is not yet complete, somewhat enhanced discharge of nematocysts occurs into targets touched to tentacles in the presence of nearby vibrations at 56Hz (at least as compared to the response of CD-treated animals to contact with test probes in the absence of vibrations). Additionally, at 2h after CD-treatment, prey capture recovers to normal. Thus, two populations of hair bundles may be present on tentacles of sea anemones: those that are CD-resistant and those that are CD-sensitive. The functions of these hair bundles may be distinct. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Molecular mechanism of bundle formation by the bacterial actin ParM

    Energy Technology Data Exchange (ETDEWEB)

    Popp, David, E-mail: dpopp@imcb.a-star.edu.sg [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673 Singapore (Singapore); Narita, Akihiro [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Nagoya University Graduate School of Science, Structural Biology Research Center and Division of Biological Sciences, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Iwasa, Mitsusada [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Maeda, Yuichiro [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Nagoya University Graduate School of Science, Structural Biology Research Center and Division of Biological Sciences, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Robinson, Robert C. [Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673 Singapore (Singapore)

    2010-01-22

    The actin homolog ParM plays a microtubule-like role in segregating DNA prior to bacterial cell division. Fluorescence and cryo-electron microscopy have shown that ParM forms filament bundles between separating DNA plasmids in vivo. Given the lack of ParM bundling proteins it remains unknown how ParM bundles form at the molecular level. Here we show using time-lapse TIRF microscopy, under in vitro molecular crowding conditions, that ParM-bundle formation consists of two distinct phases. At the onset of polymerization bundle thickness and shape are determined in the form of nuclei of short helically disordered filaments arranged in a liquid-like lattice. These nuclei then undergo an elongation phase whereby they rapidly increase in length. At steady state, ParM bundles fuse into one single large aggregate. This behavior had been predicted by theory but has not been observed for any other cytomotive biopolymer, including F-actin. We employed electron micrographs of ParM rafts, which are 2-D analogs of 3-D bundles, to identify the main molecular interfilament contacts within these suprastructures. The interface between filaments is similar for both parallel and anti-parallel orientations and the distribution of filament polarity is random within a bundle. We suggest that the interfilament interactions are not due to the interactions of specific residues but rather to long-range, counter ion mediated, electrostatic attractive forces. A randomly oriented bundle ensures that the assembly is rigid and that DNA may be captured with equal efficiency at both ends of the bundle via the ParR binding protein.

  5. Bundling in Place: Translating the NGSS into Place-Based Earth-System Science Curricula

    Science.gov (United States)

    Semken, S. C.

    2016-12-01

    Bundling is the process of grouping Performance Expectations (PEs) from the Next Generation Science Standards (NGSS) into coherent units based on a defined topic, idea, question, or phenomenon. Bundling sorts the PEs for a given grade or grade band into a teachable narrative: a key stage in building curriculum, instruction, and assessment from the NGSS. To encourage and facilitate this, bundling guidelines have recently been released on the NGSS website (nextgenscience.org/glossary/bundlesbundling), and example bundles for different grade bands and disciplines are also being developed and posted there. According to these guidelines the iterative process of bundling begins with organization of PEs according to natural connections among them, and alignment of the three NGSS dimensions (Disciplinary Core Ideas, Cross-Cutting Concepts, and Science and Engineering Practices) that underpin each PE. Bundles are grouped by coherence and increasing complexity into courses, and courses into course sets that should encompass all PEs for a grade band. Bundling offers a natural way to translate the NGSS into highly contextualized curricula such as place-based (PB) teaching, which is situated in specific places or regions and focused on natural and cultural features, processes, phenomena, history, and challenges to sustainability therein. Attributes of place and our individual and collective connections to place (sense of place) directly inform PB curriculum, pedagogy, and assessment. PEs can be bundled by their relevance to these themes. Following the NGSS guidelines, I model the process for PB instruction by bundling PEs around the themes of Paleozoic geology and carbonate deposition and their relationships to mining and calcining of limestone in Anthropocene cement production for developing communities. The bundles integrate aspects of Earth history, the carbon cycle, mineral resources, climate change, and sustainability using specific local examples and narratives. They are

  6. Natriuretic Peptides, Diagnostic and Prognostic Biomarkers

    NARCIS (Netherlands)

    J.H.W. Rutten (Joost)

    2010-01-01

    textabstractIn humans, the natriuretic peptide family consists of three different types of peptides: atrial natriuretic peptide (synonym: atrial natriuretic factor), B-type natriuretic peptide (synonym: brain natriuretic peptide) and C-natriuretic peptide.1 Atrial natriuretic peptide (ANP) was

  7. Translating Pressure Ulcer Prevention Into Intensive Care Nursing Practice: Overlaying a Care Bundle Approach With a Model for Research Implementation.

    Science.gov (United States)

    Tayyib, Nahla; Coyer, Fiona

    This article reports on the development and implementation process used to integrate a care bundle approach (a pressure ulcer [PU] prevention bundle to improve patients' skin integrity in intensive care) and the Ottawa Model of Research Use (OMRU). The PU prevention care bundle demonstrated significant reduction in PU incidence, with the OMRU model providing a consolidated framework for the implementation of bundled evidence in an effective and consistent manner into daily clinical nursing practice.

  8. Natriuretic Peptides, Diagnostic and Prognostic Biomarkers

    OpenAIRE

    Rutten, Joost

    2010-01-01

    textabstractIn humans, the natriuretic peptide family consists of three different types of peptides: atrial natriuretic peptide (synonym: atrial natriuretic factor), B-type natriuretic peptide (synonym: brain natriuretic peptide) and C-natriuretic peptide.1 Atrial natriuretic peptide (ANP) was the fi rst natriuretic peptide to be discovered and in humans ANP is predominantly formed in the cardiomyocytes of the atria.2 B-type natriuretic peptide (BNP) was fi rst discovered in porcine brain hen...

  9. Granin-derived peptides.

    Science.gov (United States)

    Troger, Josef; Theurl, Markus; Kirchmair, Rudolf; Pasqua, Teresa; Tota, Bruno; Angelone, Tommaso; Cerra, Maria C; Nowosielski, Yvonne; Mätzler, Raphaela; Troger, Jasmin; Gayen, Jaur R; Trudeau, Vance; Corti, Angelo; Helle, Karen B

    2017-07-01

    The granin family comprises altogether 7 different proteins originating from the diffuse neuroendocrine system and elements of the central and peripheral nervous systems. The family is dominated by three uniquely acidic members, namely chromogranin A (CgA), chromogranin B (CgB) and secretogranin II (SgII). Since the late 1980s it has become evident that these proteins are proteolytically processed, intragranularly and/or extracellularly into a range of biologically active peptides; a number of them with regulatory properties of physiological and/or pathophysiological significance. The aim of this comprehensive overview is to provide an up-to-date insight into the distribution and properties of the well established granin-derived peptides and their putative roles in homeostatic regulations. Hence, focus is directed to peptides derived from the three main granins, e.g. to the chromogranin A derived vasostatins, betagranins, pancreastatin and catestatins, the chromogranin B-derived secretolytin and the secretogranin II-derived secretoneurin (SN). In addition, the distribution and properties of the chromogranin A-derived peptides prochromacin, chromofungin, WE14, parastatin, GE-25 and serpinins, the CgB-peptide PE-11 and the SgII-peptides EM66 and manserin will also be commented on. Finally, the opposing effects of the CgA-derived vasostatin-I and catestatin and the SgII-derived peptide SN on the integrity of the vasculature, myocardial contractility, angiogenesis in wound healing, inflammatory conditions and tumors will be discussed. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Peptide Optical waveguides.

    Science.gov (United States)

    Handelman, Amir; Apter, Boris; Shostak, Tamar; Rosenman, Gil

    2017-02-01

    Small-scale optical devices, designed and fabricated onto one dielectric substrate, create integrated optical chip like their microelectronic analogues. These photonic circuits, based on diverse physical phenomena such as light-matter interaction, propagation of electromagnetic waves in a thin dielectric material, nonlinear and electro-optical effects, allow transmission, distribution, modulation, and processing of optical signals in optical communication systems, chemical and biological sensors, and more. The key component of these optical circuits providing both optical processing and photonic interconnections is light waveguides. Optical confinement and transmitting of the optical waves inside the waveguide material are possible due to the higher refractive index of the waveguides in comparison with their surroundings. In this work, we propose a novel field of bionanophotonics based on a new concept of optical waveguiding in synthetic elongated peptide nanostructures composed of ordered peptide dipole biomolecules. New technology of controllable deposition of peptide optical waveguiding structures by nanofountain pen technique is developed. Experimental studies of refractive index, optical transparency, and linear and nonlinear waveguiding in out-of-plane and in-plane diphenylalanine peptide nanotubes have been conducted. Optical waveguiding phenomena in peptide structures are simulated by the finite difference time domain method. The advantages of this new class of bio-optical waveguides are high refractive index contrast, wide spectral range of optical transparency, large optical nonlinearity, and electro-optical effect, making them promising for new applications in integrated multifunctional photonic circuits. Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd. Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd.

  11. Diversity-oriented peptide stapling

    DEFF Research Database (Denmark)

    Tran, Thu Phuong; Larsen, Christian Ørnbøl; Røndbjerg, Tobias

    2017-01-01

    The introduction of macrocyclic constraints in peptides (peptide stapling) is an important tool within peptide medicinal chemistry for stabilising and pre-organising peptides in a desired conformation. In recent years, the copper-catalysed azide-alkyne cycloaddition (CuAAC) has emerged...... as a powerful method for peptide stapling. However, to date CuAAC stapling has not provided a simple method for obtaining peptides that are easily diversified further. In the present study, we report a new diversity-oriented peptide stapling (DOPS) methodology based on CuAAC chemistry. Stapling of peptides...... incorporating two azide-modified amino acids with 1,3,5-triethynylbenzene efficiently provides (i, i+7)- and (i, i+9)-stapled peptides with a single free alkyne positioned on the staple, that can be further conjugated or dimerised. A unique feature of the present method is that it provides easy access...

  12. Targeting diverse protein–protein interaction interfaces with α/β-peptides derived from the Z-domain scaffold

    Science.gov (United States)

    Checco, James W.; Kreitler, Dale F.; Thomas, Nicole C.; Belair, David G.; Rettko, Nicholas J.; Murphy, William L.; Forest, Katrina T.; Gellman, Samuel H.

    2015-01-01

    Peptide-based agents derived from well-defined scaffolds offer an alternative to antibodies for selective and high-affinity recognition of large and topologically complex protein surfaces. Here, we describe a strategy for designing oligomers containing both α- and β-amino acid residues (“α/β-peptides”) that mimic several peptides derived from the three-helix bundle “Z-domain” scaffold. We show that α/β-peptides derived from a Z-domain peptide targeting vascular endothelial growth factor (VEGF) can structurally and functionally mimic the binding surface of the parent peptide while exhibiting significantly decreased susceptibility to proteolysis. The tightest VEGF-binding α/β-peptide inhibits the VEGF165-induced proliferation of human umbilical vein endothelial cells. We demonstrate the versatility of this strategy by showing how principles underlying VEGF signaling inhibitors can be rapidly extended to produce Z-domain–mimetic α/β-peptides that bind to two other protein partners, IgG and tumor necrosis factor-α. Because well-established selection techniques can identify high-affinity Z-domain derivatives from large DNA-encoded libraries, our findings should enable the design of biostable α/β-peptides that bind tightly and specifically to diverse targets of biomedical interest. Such reagents would be useful for diagnostic and therapeutic applications. PMID:25825775

  13. Antimicrobial Peptides from Plants

    Directory of Open Access Journals (Sweden)

    James P. Tam

    2015-11-01

    Full Text Available Plant antimicrobial peptides (AMPs have evolved differently from AMPs from other life forms. They are generally rich in cysteine residues which form multiple disulfides. In turn, the disulfides cross-braced plant AMPs as cystine-rich peptides to confer them with extraordinary high chemical, thermal and proteolytic stability. The cystine-rich or commonly known as cysteine-rich peptides (CRPs of plant AMPs are classified into families based on their sequence similarity, cysteine motifs that determine their distinctive disulfide bond patterns and tertiary structure fold. Cystine-rich plant AMP families include thionins, defensins, hevein-like peptides, knottin-type peptides (linear and cyclic, lipid transfer proteins, α-hairpinin and snakins family. In addition, there are AMPs which are rich in other amino acids. The ability of plant AMPs to organize into specific families with conserved structural folds that enable sequence variation of non-Cys residues encased in the same scaffold within a particular family to play multiple functions. Furthermore, the ability of plant AMPs to tolerate hypervariable sequences using a conserved scaffold provides diversity to recognize different targets by varying the sequence of the non-cysteine residues. These properties bode well for developing plant AMPs as potential therapeutics and for protection of crops through transgenic methods. This review provides an overview of the major families of plant AMPs, including their structures, functions, and putative mechanisms.

  14. Peptide Integrated Optics.

    Science.gov (United States)

    Handelman, Amir; Lapshina, Nadezda; Apter, Boris; Rosenman, Gil

    2018-02-01

    Bio-nanophotonics is a wide field in which advanced optical materials, biomedicine, fundamental optics, and nanotechnology are combined and result in the development of biomedical optical chips. Silk fibers or synthetic bioabsorbable polymers are the main light-guiding components. In this work, an advanced concept of integrated bio-optics is proposed, which is based on bioinspired peptide optical materials exhibiting wide optical transparency, nonlinear and electrooptical properties, and effective passive and active waveguiding. Developed new technology combining bottom-up controlled deposition of peptide planar wafers of a large area and top-down focus ion beam lithography provides direct fabrication of peptide optical integrated circuits. Finding a deep modification of peptide optical properties by reconformation of biological secondary structure from native phase to β-sheet architecture is followed by the appearance of visible fluorescence and unexpected transition from a native passive optical waveguiding to an active one. Original biocompatibility, switchable regimes of waveguiding, and multifunctional nonlinear optical properties make these new peptide planar optical materials attractive for application in emerging technology of lab-on-biochips, combining biomedical photonic and electronic circuits toward medical diagnosis, light-activated therapy, and health monitoring. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Association between cingulum bundle structure and cognitive performance: an observational study in major depression.

    Science.gov (United States)

    Schermuly, I; Fellgiebel, A; Wagner, S; Yakushev, I; Stoeter, P; Schmitt, R; Knickenberg, R J; Bleichner, F; Beutel, M E

    2010-10-01

    Major depression can be regarded as a systemic neurobehavioral disorder resulting from dysfunction of the limbic-cortical networks. The cingulum bundle represents a major association fiber tract of those networks. The aim of our study was to determine the association of brain structural tissue markers of the cingulum bundle and cognitive function in patients with major depression. Region-of-interest-based analyses of the middle-anterior and middle-posterior cingulum bundle fractional anisotropy (FA) and mean diffusivity (MD) using color-coded diffusion-tensor imaging and neuropsychological assessment in 14 patients with major depression. FA of the middle-anterior and middle-posterior cingulum bundle was significantly correlated to the performance in a planning and divided attention task. Furthermore, MD of the middle-posterior cingulum bundle was significantly correlated to a planning task. There was no significant correlation between FA and MD of the cingulum bundle and selective attention or memory. Brain structural tissue markers of the middle-anterior and middle-posterior cingulum bundle were found to be associated with executive functioning and divided attention in patients with major depression. Disconnection within the limbic-cortical networks may underlay cognitive dysfunction in major depression. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

  16. The button effect of CANFLEX bundle on the critical heat flux and critical channel power

    Energy Technology Data Exchange (ETDEWEB)

    Park, Joo Hwan; Jun, Jisu; Suk, Ho Chun [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of); Dimmick, G. R.; Bullock, D. E.; Inch, W. [Atomic Energy of Canada Limited, Ontario (Canada)

    1997-12-31

    A CANFLEX (CANdu FLEXible fuelling) 43-element bundle has developed for a CANDU-6 reactor as an alternative of 37-element fuel bundle. The design has two diameter elements (11.5 and 13.5 mm) to reduce maximum element power rating and buttons to enhance the critical heat flux (CHF), compared with the standard 37-element bundle. The freon CHF experiments have performed for two series of CANFLEX bundles with and without buttons with a modelling fluid as refrigerant R-134a and axial uniform heat flux condition. Evaluating the effects of buttons of CANFLEX bundle on CHF and Critical Channel Power (CCP) with the experimental results, it is shown that the buttons enhance CCP as well as CHF. All the CHF`s for both the CANFLEX bundles are occurred at the end of fuel channel with the high dryout quality conditions. The CHF enhancement ratio are increased with increase of dryout quality for all flow conditions and also with increase of mass flux only for high pressure conditions. It indicates that the button is a useful design for CANDU operating condition because most CHF flow conditions for CANDU fuel bundle are ranged to high dryout quality conditions. 5 refs., 11 figs. (Author)

  17. Food bundling as a health nudge: Investigating consumer fruit and vegetable selection using behavioral economics.

    Science.gov (United States)

    Carroll, Kathryn A; Samek, Anya; Zepeda, Lydia

    2018-02-01

    Displaying bundles of healthy foods at the grocery store is a health nudge that simplifies shopping and may have the potential for increasing fruit and vegetable (F&V) purchasing. To evaluate the impact of food bundling, we conduct an artefactual field experiment with community participants in a laboratory set up as a grocery store. Dual-self theory suggests that food choices may differ depending on whether shoppers are under cognitive load - in our experiment, we exogenously vary whether bundles are displayed (with and without a price discount) and whether shoppers are under cognitive load. Our findings align with prior studies that suggest unhealthy options are more likely to be selected when cognitive resources are constrained. When bundles are displayed, we observe increased F&V purchasing. We also observe a significant interaction between cognitive load and price discounting. We find discounted bundles are more effective in the absence of cognitive load, but non-discounted bundles are more effective when shoppers are under cognitive load. Although more research is warranted, our findings suggest that when shopping under cognitive load, it is possible that discounts impose additional cognitive strain on the shopping experience. For retailers and policymakers, our results point to the potential power of bundling as a strategy for increasing healthy food purchasing. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Cysteine-rich protein 1 (CRP1 regulates actin filament bundling

    Directory of Open Access Journals (Sweden)

    Fraley Tamara S

    2005-12-01

    Full Text Available Abstract Background Cysteine-rich protein 1 (CRP1 is a LIM domain containing protein localized to the nucleus and the actin cytoskeleton. CRP1 has been demonstrated to bind the actin-bundling protein α-actinin and proposed to modulate the actin cytoskeleton; however, specific regulatory mechanisms have not been identified. Results CRP1 expression increased actin bundling in rat embryonic fibroblasts. Although CRP1 did not affect the bundling activity of α-actinin, CRP1 was found to stabilize the interaction of α-actinin with actin bundles and to directly bundle actin microfilaments. Using confocal and photobleaching fluorescence resonance energy transfer (FRET microscopy, we demonstrate that there are two populations of CRP1 localized along actin stress fibers, one associated through interaction with α-actinin and one that appears to bind the actin filaments directly. Consistent with a role in regulating actin filament cross-linking, CRP1 also localized to the membrane ruffles of spreading and PDGF treated fibroblasts. Conclusion CRP1 regulates actin filament bundling by directly cross-linking actin filaments and stabilizing the interaction of α-actinin with actin filament bundles.

  19. A Short Double-Stapled Peptide Inhibits Respiratory Syncytial Virus Entry and Spreading.

    Science.gov (United States)

    Gaillard, Vanessa; Galloux, Marie; Garcin, Dominique; Eléouët, Jean-François; Le Goffic, Ronan; Larcher, Thibaut; Rameix-Welti, Marie-Anne; Boukadiri, Abdelhak; Héritier, Julien; Segura, Jean-Manuel; Baechler, Elodie; Arrell, Miriam; Mottet-Osman, Geneviève; Nyanguile, Origène

    2017-04-01

    Synthetic peptides derived from the heptad repeat (HR) of fusion (F) proteins can be used as dominant negative inhibitors to inhibit the fusion mechanism of class I viral F proteins. Here, we have performed a stapled-peptide scan across the HR2 domain of the respiratory syncytial virus (RSV) F protein with the aim to identify a minimal domain capable of disrupting the formation of the postfusion six-helix bundle required for viral cell entry. Constraining the peptides with a single staple was not sufficient to inhibit RSV infection. However, the insertion of double staples led to the identification of novel short stapled peptides that display nanomolar potency in HEp-2 cells and are exceptionally robust to proteolytic degradation. By replacing each amino acid of the peptides by an alanine, we found that the substitution of residues 506 to 509, located in a patch of polar contacts between HR2 and HR1, severely affected inhibition. Finally, we show that intranasal delivery of the most potent peptide to BALB/c mice significantly decreased RSV infection in upper and lower respiratory tracts. The discovery of this minimal HR2 sequence as a means for inhibition of RSV infection provides the basis for further medicinal chemistry efforts toward developing RSV fusion antivirals. Copyright © 2017 Gaillard et al.

  20. Coupling and elastic loading affect the active response by the inner ear hair cell bundles.

    Directory of Open Access Journals (Sweden)

    Clark Elliott Strimbu

    Full Text Available Active hair bundle motility has been proposed to underlie the amplification mechanism in the auditory endorgans of non-mammals and in the vestibular systems of all vertebrates, and to constitute a crucial component of cochlear amplification in mammals. We used semi-intact in vitro preparations of the bullfrog sacculus to study the effects of elastic mechanical loading on both natively coupled and freely oscillating hair bundles. For the latter, we attached glass fibers of different stiffness to the stereocilia and observed the induced changes in the spontaneous bundle movement. When driven with sinusoidal deflections, hair bundles displayed phase-locked response indicative of an Arnold Tongue, with the frequency selectivity highest at low amplitudes and decreasing under stronger stimulation. A striking broadening of the mode-locked response was seen with increasing stiffness of the load, until approximate impedance matching, where the phase-locked response remained flat over the physiological range of frequencies. When the otolithic membrane was left intact atop the preparation, the natural loading of the bundles likewise decreased their frequency selectivity with respect to that observed in freely oscillating bundles. To probe for signatures of the active process under natural loading and coupling conditions, we applied transient mechanical stimuli to the otolithic membrane. Following the pulses, the underlying bundles displayed active movement in the opposite direction, analogous to the twitches observed in individual cells. Tracking features in the otolithic membrane indicated that it moved in phase with the bundles. Hence, synchronous active motility evoked in the system of coupled hair bundles by external input is sufficient to displace large overlying structures.

  1. A contribution to understanding the structure of amphivasal secondary bundles in monocotyledons

    Directory of Open Access Journals (Sweden)

    Joanna Jura-Morawiec

    2014-04-01

    Full Text Available Secondary growth of monocotyledonous plants is connected with the activity of the monocot cambium that accumulates most of the derivatives inner to the cambial cylinder. These derivatives differentiate into (a secondary bundles with the amphivasal arrangement, i.e. xylem composed of tracheids surrounds the phloem cells and (b the parenchymatous secondary conjunctive tissue in which the bundles are embedded. The amphivasal secondary bundles differ in the arrangement of xylem cells as visible on single cross sections through the secondary body of the monocots. Apart from the bundles with typical ring of tracheids also the bundles where tracheids do not quite surround the phloem are present. We aimed to elucidate the cross sectional anatomy of the amphivasal secondary bundles with the use of the serial sectioning method which allowed us to follow very precisely the bundle structure along its length. The studies were carried out with the samples of secondary tissues collected from the stem of Dracaena draco L. growing in the greenhouses of the Polish Academy of Sciences Botanical Garden – CBDC in Powsin and the Adam Mickiewicz University Botanical Garden. The material was fixed in a mixture of glycerol and ethanol (1:1; v/v, dehydrated stepwise with graded ethanol series and finally embedded in epon resin. Afterwards, the material was sectioned with microtome into continuous series of thin (3 μm sections, stained with PAS/toluidine blue and examined under the light microscope. The results, described in details in Jura‑Morawiec & Wiland-Szymańska (2014, revealed novel facts about tracheids arrangement. Each amphivasal bundle is composed of sectors where tracheids form a ring as well as of such where tracheids are separated by vascular parenchyma cells. We hypothesize that strands of vascular parenchyma cells locally separating the tracheids enable radial transport of assimilates from sieve elements of the bundle towards the sink tissues, e

  2. Biomimetic peptide nanosensors.

    Science.gov (United States)

    Cui, Yue; Kim, Sang N; Naik, Rajesh R; McAlpine, Michael C

    2012-05-15

    The development of a miniaturized sensing platform tailored for sensitive and selective detection of a variety of biochemical analytes could offer transformative fundamental and technological opportunities. Due to their high surface-to-volume ratios, nanoscale materials are extremely sensitive sensors. Likewise, peptides represent robust substrates for selective recognition due to the potential for broad chemical diversity within their relatively compact size. Here we explore the possibilities of linking peptides to nanosensors for the selective detection of biochemical targets. Such systems raise a number of interesting fundamental challenges: What are the peptide sequences, and how can rational design be used to derive selective binders? What nanomaterials should be used, and what are some strategies for assembling hybrid nanosensors? What role does molecular modeling play in elucidating response mechanisms? What is the resulting performance of these sensors, in terms of sensitivity, selectivity, and response time? What are some potential applications? This Account will highlight our early attempts to address these research challenges. Specifically, we use natural peptide sequences or sequences identified from phage display as capture elements. The sensors are based on a variety of nanomaterials including nanowires, graphene, and carbon nanotubes. We couple peptides to the nanomaterial surfaces via traditional surface functionalization methods or self-assembly. Molecular modeling provides detailed insights into the hybrid nanostructure, as well as the sensor detection mechanisms. The peptide nanosensors can distinguish chemically camouflaged mixtures of vapors and detect chemical warfare agents with sensitivities as low as parts-per-billion levels. Finally, we anticipate future uses of this technology in biomedicine: for example, devices based on these sensors could detect disease from the molecular components in human breath. Overall, these results provide a

  3. Magnetic resonance imaging of double-bundle anterior cruciate ligament reconstruction

    Energy Technology Data Exchange (ETDEWEB)

    Poellinger, Alexander; Hamm, Bernd; Asbach, Patrick [Charite, Department of Radiology, Berlin (Germany); Scheffler, Sven [Charite, Department for Orthopaedic Surgery and Traumatology, Center for Musculoskeletal Surgery, Berlin (Germany)

    2009-04-15

    Reconstruction of the anterior cruciate ligament (ACL) using the double-bundle technique is getting highly increasing attention. This surgical approach uses two separate tendon grafts with the intention to reconstruct both anatomic bundles in order to restore the full biomechanical function of the original ligament. With the increasing popularity of this technique, radiologists will be more frequently confronted with patients who underwent this surgical procedure. The aims of this essay are to briefly describe the basic biomechanical and surgical principles and to summarize the magnetic resonance imaging findings of the knee after double-bundle ACL reconstruction. (orig.)

  4. Coolant mixing in LMFBR rod bundles and outlet plenum mixing transients

    Science.gov (United States)

    Todreas, N. E.; Cheng, S. K.; Basehore, K.

    1984-08-01

    The thermal hydraulic performance of wire wrapped fuel bundles of LMFBR configuration was investigated. Results obtained included phenomenological models for friction factors, flow split and mixing characteristics; correlations for predicting these characteristics suitable for insertion in design codes; numerical codes for analyzing bundle behavior both of the lumped subchannel and distributed parameter categories and experimental techniques for pressure velocity, flow split, salt conductivity and temperature measurement in water cooled mockups of bundles and subchannels. Flow regimes investigated included laminar, transition and turbulent flow under forced convection and mixed convection conditions. Forced convections conditions are emphasized. Outlet plenum behavior is also investigated.

  5. Two-phase pressure drops for CANDU fuel bundles in uncrept and crept channels

    Energy Technology Data Exchange (ETDEWEB)

    Sutradhar, S.C. [Atomic Energy of Canada Ltd., Chalk River, Ontario (Canada)

    2001-07-01

    Pressure-drop tests in Freon-134a were performed on aligned and misaligned 37-element CANDU (C6) fuel bundles in uncrept and 3% crept channels. The results indicate that the two-phase pressure-drop profiles are similar in shape, but higher in magnitude, compared with the single-phase pressure-drop profiles. The two-phase multipliers (TPMs) are a strong function of the thermodynamic quality of the fluid. The measured TPMs of the bundles in the uncrept channel are higher than those in the crept channel. The measured TPMs for the aligned bundles agree well with the Beattie correlation. (author)

  6. Parabolic Higgs bundles and Teichmüller spaces for punctured surfaces

    CERN Document Server

    Biswas, I; Govindarajan, S; Biswas, Indranil; Gastesi, Pablo; Govindarajan, Suresh

    1995-01-01

    In this paper we study the relation between parabolic Higgs bundles and irreducible representations of the fundamental group of punctured Riemann surfaces established by Simpson. We generalize a result of Hitchin, identifying those parabolic Higgs bundles that correspond to Fuchsian representations. We also study the Higgs bundles that give representations whose image is contained, after conjugation, in SL(k,\\Bbb R). We compute the real dimension of one of the components of this space of representations, which in the absence of punctures is the generalized Teichm\\"uller space introduced by Hitchin, and which in the case of k=2 is the Teichm\\"uller space of the Riemann surface.

  7. Immunotherapy with Allergen Peptides

    Directory of Open Access Journals (Sweden)

    Larché Mark

    2007-06-01

    Full Text Available Specific allergen immunotherapy (SIT is disease-modifying and efficacious. However, the use of whole allergen preparations is associated with frequent allergic adverse events during treatment. Many novel approaches are being designed to reduce the allergenicity of immunotherapy preparations whilst maintaining immunogenicity. One approach is the use of short synthetic peptides which representing dominant T cell epitopes of the allergen. Short peptides exhibit markedly reduced capacity to cross link IgE and activate mast cells and basophils, due to lack of tertiary structure. Murine pre-clinical studies have established the feasibility of this approach and clinical studies are currently in progress in both allergic and autoimmune diseases.

  8. Therapeutic HIV Peptide Vaccine

    DEFF Research Database (Denmark)

    Fomsgaard, Anders

    2015-01-01

    Therapeutic vaccines aim to control chronic HIV infection and eliminate the need for lifelong antiretroviral therapy (ART). Therapeutic HIV vaccine is being pursued as part of a functional cure for HIV/AIDS. We have outlined a basic protocol for inducing new T cell immunity during chronic HIV-1...... infection directed to subdominant conserved HIV-1 epitopes restricted to frequent HLA supertypes. The rationale for selecting HIV peptides and adjuvants are provided. Peptide subunit vaccines are regarded as safe due to the simplicity, quality, purity, and low toxicity. The caveat is reduced immunogenicity...

  9. Polyclonal and monoclonal antibodies specific for the six-helix bundle of the human respiratory syncytial virus fusion glycoprotein as probes of the protein post-fusion conformation

    Energy Technology Data Exchange (ETDEWEB)

    Palomo, Concepción; Mas, Vicente; Vázquez, Mónica; Cano, Olga [Unidad de Biología Viral, Centro Nacional de Microbiología, Madrid (Spain); CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid (Spain); Luque, Daniel; Terrón, María C. [Unidad de Microscopía Electrónica y Confocal, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid (Spain); Calder, Lesley J. [National Institute for Medical Research, MRC, Mill Hill, London NW7 1AA (United Kingdom); Melero, José A., E-mail: jmelero@isciii.es [Unidad de Biología Viral, Centro Nacional de Microbiología, Madrid (Spain); CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid (Spain)

    2014-07-15

    Human respiratory syncytial virus (hRSV) has two major surface glycoproteins (G and F) anchored in the lipid envelope. Membrane fusion promoted by hRSV{sub F} occurs via refolding from a pre-fusion form to a highly stable post-fusion state involving large conformational changes of the F trimer. One of these changes results in assembly of two heptad repeat sequences (HRA and HRB) into a six-helix bundle (6HB) motif. To assist in distinguishing pre- and post-fusion conformations of hRSV{sub F}, we have prepared polyclonal (α-6HB) and monoclonal (R145) rabbit antibodies specific for the 6HB. Among other applications, these antibodies were used to explore the requirements of 6HB formation by isolated protein segments or peptides and by truncated mutants of the F protein. Site-directed mutagenesis and electron microscopy located the R145 epitope in the post-fusion hRSV{sub F} at a site distantly located from previously mapped epitopes, extending the repertoire of antibodies that can decorate the F molecule. - Highlights: • Antibodies specific for post-fusion respiratory syncytial virus fusion protein are described. • Polyclonal antibodies were obtained in rabbit inoculated with chimeric heptad repeats. • Antibody binding required assembly of a six-helix bundle in the post-fusion protein. • A monoclonal antibody with similar structural requirements is also described. • Binding of this antibody to the post-fusion protein was visualized by electron microscopy.

  10. Biosynthesis of cardiac natriuretic peptides

    DEFF Research Database (Denmark)

    Goetze, Jens Peter

    2010-01-01

    Cardiac-derived peptide hormones were identified more than 25 years ago. An astonishing amount of clinical studies have established cardiac natriuretic peptides and their molecular precursors as useful markers of heart disease. In contrast to the clinical applications, the biogenesis of cardiac....... An inefficient post-translational prohormone maturation will also affect the biology of the cardiac natriuretic peptide system. This review aims at summarizing the myocardial synthesis of natriuretic peptides focusing on B-type natriuretic peptide, where new data has disclosed cardiac myocytes as highly...... competent endocrine cells. The structurally related atrial natriuretic peptide will be mentioned where appropriate, whereas C-type natriuretic peptide will not be considered as a cardiac peptide of relevance in mammalian physiology....

  11. Fission product release assessment for end fitting failure in Candu reactor loaded with CANFLEX-NU fuel bundles

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Dirk Joo; Jeong, Chang Joon; Lee, Kang Moon; Suk, Ho Chun [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1997-12-31

    Fission product release (FPR) assessment for End Fitting Failure (EFF) in CANDU reactor loaded with CANFLEX-natural uranium (NU) fuel bundles has been performed. The predicted results are compared with those for the reactor loaded with standard 37-element bundles. The total channel I-131 release at the end of transient for EFF accident is calculated to be 380.8 TBq and 602.9 TBq for the CANFLEX bundle and standard bundle channel cases, respectively. They are 4.9% and 7.9% of total inventory, respectively. The lower total releases of the CANFLEX bundle O6 channel are attributed to the lower initial fuel temperatures caused by the lower linear element power of the CANFLEX bundle compared with the standard bundle. 4 refs., 1 fig., 4 tabs. (Author)

  12. [Right Bundle Branch Block, Left Bundle Branch Block, Pace Maker in Case of Acute Coronary Syndrome - is the ECG of any Value?

    Science.gov (United States)

    Grautoff, Steffen

    2017-01-01

    The 12 lead ECG is difficult to evaluate if there is a persistent right or even left bundle block or a pace maker continually stimulating the right ventricle. Despite these pre-existing or new ECG changes it might still be possible to detect variations which can hint to an ST-elevation myocardial infarction (STEMI). Diagnosing significant ST elevations in a case of right bundle block is not very challenging. If the ECG shows a left bundle block the modified Sgarbossa criteria should be used for evaluation. These criteria can also be used in a pace maker ECG. If a patient is not pacemaker-dependent the stimulation can be paused transiently to reveal changes of the ST segment. At first medical contact it can be very important to assess these changes correctly in order to classify the ECG as a STEMI. © Georg Thieme Verlag KG Stuttgart · New York.

  13. Plasticity in bundle sheath extensions of heterobaric leaves.

    Science.gov (United States)

    Lynch, Douglas J; McInerney, Francesca A; Kouwenberg, Lenny L R; Gonzalez-Meler, Miquel A

    2012-07-01

    Leaf venation is linked to physiological performance, playing a critical role in ecosystem function. Despite the importance of leaf venation, associated bundle sheath extensions (BSEs) remain largely unstudied. Here, we quantify plasticity in the spacing of BSEs over irradiance and precipitation gradients. Because physiological function(s) of BSEs remain uncertain, we additionally explored a link between BSEs and water use efficiency (WUE). We sampled leaves of heterobaric trees along intracrown irradiance gradients in natural environments and growth chambers and correlated BSE spacing to incident irradiance. Additionally, we sampled leaves along a precipitation gradient and correlated BSE spacing to precipitation and bulk δ(13)C, a proxy for intrinsic WUE. BSE spacing was quantified using a novel semiautomatic method on fresh leaf tissue. With increased irradiance or decreased precipitation, Liquidambar styraciflua decreased BSE spacing, while Acer saccharum showed little variation in BSE spacing. Two additional species, Quercus robur and Platanus occidentalis, decreased BSE spacing with increased irradiance in growth chambers. BSE spacing correlated with bulk δ(13)C, a proxy for WUE in L. styraciflua, Q. robur, and P. occidentalis leaves but not in leaves of A. saccharum. We demonstrated that BSE spacing is plastic with respect to irradiance or precipitation and independent from veins, indicating BSE involvement in leaf adaptation to a microenvironment. Plasticity in BSE spacing was correlated with WUE only in some species, not supporting a function in water relations. We discuss a possible link between BSE plasticity and life history, particularly canopy position.

  14. Bundled-Optode Method in Functional Near-Infrared Spectroscopy.

    Directory of Open Access Journals (Sweden)

    Hoang-Dung Nguyen

    Full Text Available In this paper, a theory for detection of the absolute concentrations of oxy-hemoglobin (HbO and deoxy-hemoglobin (HbR from hemodynamic responses using a bundled-optode configuration in functional near-infrared spectroscopy (fNIRS is proposed. The proposed method is then applied to the identification of two fingers (i.e., little and thumb during their flexion and extension. This experiment involves a continuous-wave-type dual-wavelength (760 and 830 nm fNIRS and five healthy male subjects. The active brain locations of two finger movements are identified based on the analysis of the t- and p-values of the averaged HbOs, which are quite distinctive. Our experimental results, furthermore, revealed that the hemodynamic responses of two-finger movements are different: The mean, peak, and time-to-peak of little finger movements are higher than those of thumb movements. It is noteworthy that the developed method can be extended to 3-dimensional fNIRS imaging.

  15. RBA: Reduced Bundle Adjustment for oblique aerial photogrammetry

    Science.gov (United States)

    Sun, Yanbiao; Sun, Huabo; Yan, Lei; Fan, Shiyue; Chen, Rui

    2016-11-01

    This study proposes an efficient Bundle Adjustment (BA) model for oblique aerial photogrammetry to reduce the number of unknown parameters and the dimensions of a non-linear optimization problem. Instead of serving as independent exterior orientations, oblique camera poses are parameterized with nadir camera poses and constant relative poses between oblique and nadir cameras. New observation functions are created with image points as a function of the nadir pose and the relative pose parameters. With these observation functions, the problem of BA is defined as finding optimal unknown parameters by minimizing the total difference between estimated and observed image points. A Gauss-Newton optimization method is utilized to provide a solution for this least-square problem with a reduced normal equation, which plays a very critical role in the convergence and efficiency of BA. Compared with traditional BA methods, the number of unknown parameters and the dimension of the normal equations decrease, this approach dramatically reduces the computational complexity and memory cost especially for large-scale scenarios with a number of oblique images. Four synthetic datasets and a real dataset were used to check the validation and the accuracy of the proposed method. The accuracy of the proposed method is very close to that of the traditional BA method, but the efficiency can be significantly improved by the proposed method. For very large-scale scenarios, the proposed method can still address the limitation of memory and orientate all images captured by an oblique aerial multi-camera system.

  16. Brugada syndrome behind complete right bundle-branch block.

    Science.gov (United States)

    Aizawa, Yoshiyasu; Takatsuki, Seiji; Sano, Motoaki; Kimura, Takehiro; Nishiyama, Nobuhiro; Fukumoto, Kotaro; Tanimoto, Yoko; Tanimoto, Kojiro; Murata, Mitsushige; Komatsu, Takashi; Mitamura, Hideo; Ogawa, Satoshi; Funazaki, Toshikazu; Sato, Masahito; Aizawa, Yoshifusa; Fukuda, Keiichi

    2013-09-03

    The characteristic ECG of Brugada syndrome (BS) can be masked by complete right bundle-branch block (CRBBB) and exposed by resolution of the block or pharmacological or pacing maneuvers. The study consisted of 11 patients who had BS and CRBBB. BS was diagnosed before the development of CRBBB, on the resolution of CRBBB, or from new characteristic ST-segment changes that could be attributable to BS. Structural heart diseases were excluded, and coronary spasm was excluded on the basis of a provocation test at catheterization. In 7 patients, BS was diagnosed before the development of CRBBB. BS was diagnosed when CRBBB resolved spontaneously (n=1) or by right ventricular pacing (n=3). The precipitating cause for the spontaneous resolution of CRBBB, however, was not apparent. On repeated ECGs, new additional upward-convex ST-segment elevation was found in V2 or V3 in 3 patients. In 2 patients, new ST-segment elevation was induced by class IC drugs. The QRS duration was more prolonged in patients with BS and CRBBB compared with age- and sex-matched controls: 170±13 versus 145±15 milliseconds in V1 and 144±19 versus 128±7 milliseconds in V5 (both Pmask BS. BS might be demonstrated by relief of CRBBB or by spontaneous or drug-induced ST-segment elevation. The prevalence, mechanism, and clinical significance of a combination of CRBBB and BS are yet to be determined.

  17. Application and Performance Analysis of a New Bundle Adjustment Model

    Science.gov (United States)

    Sun, Y.; Liu, X.; Chen, R.; Wan, J.; Wang, Q.; Wang, H.; Li, Y.; Yan, L.

    2017-09-01

    As the basis for photogrammetry, Bundle Adjustment (BA) can restore the pose of cameras accurately, reconstruct the 3D models of environment, and serve as the criterion of digital production. For the classical nonlinear optimization of BA model based on the Euclidean coordinate, it suffers the problem of being seriously dependent on the initial values, making it unable to converge fast or converge to a global minimum. This paper first introduces a new BA model based on parallax angle feature parametrization, and then analyses the applications and performance of the model used in photogrammetry field. To discuss the impact and the performance of the model (especially in aerial photogrammetry), experiments using two aerial datasets under different initial values were conducted. The experiment results are better than some well-known software packages of BA, and the simulation results illustrate the stability of the new model than the normal BA under the Euclidean coordinate. In all, the new BA model shows promising applications in faster and more efficient aerial photogrammetry with good convergence and fast convergence speed.

  18. Group systems, groupoids, and moduli spaces of parabolic bundles

    CERN Document Server

    Guruprasad, K; Jeffrey, L; Weinstein, A

    1997-01-01

    Let $G$ be a Lie group, with an invariant non-degenerate symmetric bilinear form on its Lie algebra, let $\\pi$ be the fundamental group of an orientable (real) surface $M$ with a finite number of punctures, and let $\\bold C$ be a family of conjugacy classes in $G$, one for each puncture. A finite-dimensional construction used earlier to obtain a symplectic structure on the moduli space of flat $G$-bundles over compact $M$ is extended to the punctured case. It yields a symplectic structure on a certain smooth manifold $\\Cal M_{\\bold C}$ containing the space $\\roman{Hom}(\\pi,G)_{\\bold C}$ of homomorphisms mapping the generators corresponding to the punctures into the corresponding conjugacy classes. It also yields a Hamiltonian $G$-action on $\\Cal M_{\\bold C}$ such that the reduced space equals the moduli space $\\roman{Rep}(\\pi,G)_{\\bold C}$ of representations. For $G$ compact, each such space, obtained by finite-dimensional symplectic reduction, is a {\\it stratified symplectic space\\/}. For $G=U(n)$ one gets m...

  19. Turbulent transports by secondary flow vortices in a rod bundle

    Energy Technology Data Exchange (ETDEWEB)

    Vonka, V.

    1988-02-01

    Experimental data on secondary flow vortices in a rod bundle with pitch-to-diameter ratio P/D=1.3 show weak vortices with the average velocity magnitude only about 0.1% of the mean bulk velocity. The question then arises, how important these weak vortices could still be as a transport mechanism in turbulent flows. The transport of axial momentum by these vortices is analysed quantitatively. While a minor importance is observed for the transport in radial direction, it is found that about half of the total transport in circumferential direction is due to the secondary flow vortex convection. Based on the analogy between the transport of momentum and heat, it is expected in nonisothermal situations that, in radial direction, the contribution can improve the heat transfer coefficient and contribute to better economy of heat transfer installations. In circumferential direction, the contribution helps to smooth out circumferential temperature differences, improves the heat removal from heated surfaces and, through a decrease of the maximum surface temperature, it contributes to passive safety of heat transfer installations.

  20. GROUPS IN PEPTIDE SYNTHESIS

    African Journals Online (AJOL)

    carboxamide protecting group in peptide synthesis. RESULTS AND DISCUSSION l-Tetralinylamines used as precursors to prepare the carboxamide derivatives of asparagine and glutamine are shown in Table 1: Table 1. Summary of l-tetralinyl amines. Amines Aromatic ring NHZ. X Y Z Z. 1 H H H. 2 OCH; H H. 3 H OCH ...

  1. Natriuretic peptides and cerebral hemodynamics

    DEFF Research Database (Denmark)

    Guo, Song; Barringer, Filippa; Zois, Nora Elisabeth

    2014-01-01

    Natriuretic peptides have emerged as important diagnostic and prognostic tools for cardiovascular disease. Plasma measurement of the bioactive peptides as well as precursor-derived fragments is a sensitive tool in assessing heart failure. In heart failure, the peptides are used as treatment...

  2. NCAM Mimetic Peptides: An Update

    DEFF Research Database (Denmark)

    Berezin, Vladimir; Bock, Elisabeth

    2008-01-01

    of combinatorial peptide libraries. The C3 and NBP10 peptides target the first Ig module whereas the ENFIN2 and ENFIN11 peptides target fibronectin type III (FN3) modules of NCAM. A number of NCAM mimetics can induce neurite outgrowth and exhibit neuroprotective and synaptic plasticity modulating properties...

  3. 'optimization' of animal peptide toxins

    African Journals Online (AJOL)

    McRoy

    peptides of ca. 4 to 70 amino acid residues, with a number of potential therapeutic applications.[1]. Because of the intrinsic structural complexities of these peptides (different types of fold and 1-5 disulfide bridges), this size range implicates that only a fraction of them (< 50-mer peptides) can routinely be produced by ...

  4. The significance of dissociation of conduction in the canine His bundle. Electrophysiological studies in vivo and in vitro.

    Science.gov (United States)

    Scherlag, B J; El-Sherif, N; Hope, R R; Lazzara, R

    1978-10-01

    Fractionated His bundle potentials were induced by ischemia or trauma in 30 anesthetized dogs, in vivo. Functional dissociation, i.e., alteration of the activation sequence of portions of these His bundle potentials was demonstrated in vivo as well as in 10 in vitro preparations of the His-Purkinje system. In vivo, plunge wire and electrode catheters were utilized to record from portions of the His bundle. During vagal-induced slowing of the heart rate, atrial pacing or His bundle pacing, His-Purkinje conduction as measured by the H-V interval was constant over a wide range of heart rates, 50-300/min. One or two hours after anterior septal artery ligation, His bundle damage manifested as split His bundle potentials (H, H'). Atrial pacing or proximal His bundle pacing induced H-H' delays with concomitant right or left bundle branch block patterns in ECG leads. However, distal His bundle pacing at comparable or even higher rates produced normal QRS complexes. In other cases, during atrial pacing or with progressive ischemia at a constant rate, H' progressively delayed during the H-V interval or even disappeared into the QRS complex with a concomitant occurrence of right or left bundle branch block. In vitro, a dissected septal preparation was studied containing the His bundle, proximal and distal right bundle and left bundle branches. Normal conduction throughout the His-Purkinje system was observed at pacing rates of 30-220/min. Punctate lesions, anatomically placed above the branching His bundle caused tachycardia-dependent, complete bundle branch blocked with concurrent temporal reversal of proximal and distal His bundle action potentials. These data suggest that ischemic or traumatic lesions in the His bundle may manifest on the electrocardiogram as bundle branch block patterns. From a clinical point of view, a critical site of lesion would markedly increase the liability for A-V blocked although the electrocardiogram alone would not indicate the actual site of

  5. Adsorption behavior of ternary mixtures of noble gases inside single-walled carbon nanotube bundles

    Science.gov (United States)

    Foroutan, Masumeh; Nasrabadi, Amir Taghavi

    2010-09-01

    In order to study the gas-storage and gas-filtering capability of carbon nanotube (CNT) bundles simultaneously, we considered the adsorption behavior of a ternary mixture of noble gases, including Argon (Ar), Krypton (Kr), and Xenon (Xe), i.e., Ar-Kr-Xe mixture, on (10, 10) single-walled carbon nanotube (SWCNT) bundles. Molecular dynamics (MD) simulations at different temperatures of (75, 100, 150, 200, 250, and 300) K were performed, and adsorption energies, self-diffusion coefficients, activation energies, and radial distribution functions (RDFs) were computed to analyze the thermodynamics, transport and structural properties of the adsorption systems. It is observed that the SWCNT bundles have larger contents of heavier noble gases compared to the lighter ones. This interesting behavior of SWCNT bundles makes them proper candidates for gas-storage and gas molecular-sieving processes.

  6. The design of self-collapsed super-strong nanotube bundles

    Science.gov (United States)

    Pugno, Nicola Maria

    2010-09-01

    The study reported in this paper suggests that the influence of the surrounding nanotubes in a bundle is nearly identical to that of a liquid having surface tension equal to the surface energy of the nanotubes. This surprising behaviour is supported by the calculation of the polygonization and especially of the self-collapse diameters, and related dog-bone configurations, of nanotubes in a bundle, in agreement with atomistic simulations and nanoscale experiments. Accordingly, we have evaluated the strength of the nanotube bundle, with or without collapsed nanotubes, assuming a sliding failure: the self-collapse can increase the strength up to a value of about ˜30%, suggesting the design of self-collapsed super-strong nanotube bundles. Other systems, such as peapods and fullerites, can be similarly treated, including the effect of the presence of a liquid, as reported in the appendices.

  7. Integrated Care Pathways and Care Bundles for Dementia in Acute Care: Concept Versus Evidence.

    Science.gov (United States)

    Sullivan, Dawn O; Mannix, Mary; Timmons, Suzanne

    2017-06-01

    Caring for people with dementia in acute settings is challenging and confounded by multiple comorbidities and difficulties transitioning between community and acute care. Recently, there has been an increase in the development and use of integrated care pathways (ICPs) and care bundles for defined illnesses and medical procedures, and these are now being promoted for use in dementia care in acute settings. We present a review of the literature on ICPs and/or care bundles for dementia care in the acute sector. This includes a literature overview including "gray literature" such as relevant websites, reports, and government publications. Taken together, there is clearly a growing interest in and clinical use of ICPs and care bundles for dementia. However, there is currently insufficient evidence to support the effectiveness of ICPs for dementia care in acute settings and limited evidence for care bundles for dementia in this setting.

  8. On the Quality and Efficiency of Approximate Solutions to Bundle Adjustment with Epipolar and Trifocal Constraints

    Science.gov (United States)

    Schneider, J.; Stachniss, C.; Förstner, W.

    2017-08-01

    Bundle adjustment is a central part of most visual SLAM and Structure from Motion systems and thus a relevant component of UAVs equipped with cameras. This paper makes two contributions to bundle adjustment. First, we present a novel approach which exploits trifocal constraints, i.e., constraints resulting from corresponding points observed in three camera images, which allows to estimate the camera pose parameters without 3D point estimation. Second, we analyze the quality loss compared to the optimal bundle adjustment solution when applying different types of approximations to the constrained optimization problem to increase efficiency. We implemented and thoroughly evaluated our approach using a UAV performing mapping tasks in outdoor environments. Our results indicate that the complexity of the constraint bundle adjustment can be decreased without loosing too much accuracy.

  9. Implementation of a children's hospital-wide central venous catheter insertion and maintenance bundle

    NARCIS (Netherlands)

    K. Helder MScN (Onno); R.F. Kornelisse (René); C. van der Starre (Cynthia); D. Tibboel (Dick); C.W.N. Looman (Caspar); R.M.H. Wijnen (René); M.J. Poley (Marten); E. Ista (Erwin)

    2013-01-01

    textabstractBackground: Central venous catheter-associated bloodstream infections in children are an increasingly recognized serious safety problem worldwide, but are often preventable. Central venous catheter bundles have proved effective to prevent such infections. Successful implementation

  10. Single- and Two-Phase Turbulent Mixing Rate between Subchannels in Triangle Tight Lattice Rod Bundle

    National Research Council Canada - National Science Library

    KAWAHARA, Akimaro; SADATOMI, Michio; KUDO, Hiroyuki; KANO, Keiko

    2006-01-01

    In order to obtain the data on turbulent mixing rate between triangle tight lattice subchannels, which will be adopted as the next generation BWR fuel rod bundle, adiabatic experiments were conducted...

  11. Dynamically Switching among Bundled and Single Tickets with Time-Dependent Demand Rates

    Directory of Open Access Journals (Sweden)

    Serhan Duran

    2012-01-01

    Full Text Available The most important market segmentation in sports and entertainment industry is the competition between customers that buy bundled and single tickets. A common selling practice is starting the selling season with bundled ticket sales and switching to selling single tickets later on. The aim of this practice is to increase the number of customers that buy bundles, which in return increases the load factor of the events with low demand. In this paper, we investigate the effect of time dependent demand on dynamic switching times from bundled to single ticket sales and the potential revenue gain over the case where the demand rate of events is assumed to be constant with time.

  12. Right bundle branch block and anterior wall ST elevation myocardial infarction.

    Science.gov (United States)

    Trofin, Monica; Israel, Carsten W; Barold, S Serge

    2017-09-01

    We report the case of an acute anterior wall ST elevation myocardial infarction with new left anterior fascicular block and pre-existing right bundle branch block. Due to a wide right bundle branch block, no ST segment elevation was visible in lead V1. The left anterior fascicular block was caused by proximal occlusion of the left artery descending and disappeared after acute revascularization. However, also the R' of the right bundle branch block became significantly shorter after revascularization, dismanteling a minor ST segment elevation. The ST elevation in lead V1 in anterior wall infarction and right bundle branch block may merge with the R' and cause a further QRS widening as an "equivalent" to the ST elevation.

  13. GPS-supported Bundle Adjustment Method of UAV by Considering Exposure Delay

    Directory of Open Access Journals (Sweden)

    ZHANG Chunsen

    2017-05-01

    Full Text Available The existing GPS-supported bundle adjustment method does not take into account the influence of camera exposure delay error impact in UAV photogrammetry is inconsistent which leading to the actual adjustment results are worse than the theoretical results. The mechanism of exposure delay is studied. The impact of exposure delay on GPS-supported bundle adjustment is analyzed. And a GPS-supported bundle adjustment method by considering the exposure delay is proposed. The effectiveness of the proposed method is verified by a typical dataset of 142 images. The meaning of the proposed method is that it can achieve the better aero-triangulation accuracy than the traditional GPS-supported bundle adjustment method.

  14. Energy Band Gap Study of Semiconducting Single Walled Carbon Nanotube Bundle

    Science.gov (United States)

    Elkadi, Asmaa; Decrossas, Emmanuel; El-Ghazaly, Samir

    2013-01-01

    The electronic properties of multiple semiconducting single walled carbon nanotubes (s-SWCNTs) considering various distribution inside a bundle are studied. The model derived from the proposed analytical potential function of electron density for na individual s-SWCNT is general and can be easily applied to multiple nanotubes. This work demonstrates that regardless the number of carbon nanotubes, the strong coupling occurring between the closet neighbors reduces the energy band gap of the bundle by 10%. As expected, the coupling is strongly dependent on the distance separating the s-SWCNTs. In addition, based on the developed model, it is proposed to enhance this coupling effect by applying an electric field across the bundle to significantly reduce the energy band gap of the bundle by 20%.

  15. Acute myocardial infarction and left bundle branch block with changing axis deviation.

    Science.gov (United States)

    Patanè, Salvatore; Marte, Filippo; Dattilo, Giuseppe; Sturiale, Mauro

    2012-02-09

    Changing axis deviation has been reported also during atrial fibrillation or atrial flutter. Changing axis deviation has been also reported during acute myocardial infarction associated with atrial fibrillation too or at the end of atrial fibrillation during acute myocardial infarction. Left bundle branch block is usually associated with normal or left axis deviation. Rarely the ECG shows a LBBB with changing QRS morphology and changing axis deviation. There are several possible explanations for the intermittent shift in the QRS axis in the presence of complete left bundle branch block. The most plausible explanation is the coexistence of left posterior hemiblock and predivisional left bundle branch block. We present a case of a left bundle branch block with changing axis deviation in a 93-year-old Italian woman admitted to the Cardiology Unit with an acute myocardial infarction. Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.

  16. Left bundle branch block and changing axis deviation during acute myocardial infarction.

    Science.gov (United States)

    Patanè, Salvatore; Marte, Filippo; Sturiale, Mauro

    2012-03-22

    Changing axis deviation has been reported also during atrial fibrillation or atrial flutter. Changing axis deviation has been also reported during acute myocardial infarction associated with atrial fibrillation too or at the end of atrial fibrillation during acute myocardial infarction. Left bundle branch block is usually associated with normal or left axis deviation. Rarely the ECG shows a left bundle branch block with changing QRS morphology and changing axis deviation. We present a case of a left bundle branch block with changing axis deviation in an 86-year-old Italian man admitted to the Cardiology Unit with an acute myocardial infarction. Also this case focuses attention on left bundle branch block with changing axis deviation. Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.

  17. Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin

    National Research Council Canada - National Science Library

    Liu, Haiyang; Li, Jianchao; Raval, Manmeet H; Yao, Ningning; Deng, Xiaoying; Lu, Qing; Nie, Si; Feng, Wei; Wan, Jun; Yengo, Christopher M; Liu, Wei; Zhang, Mingjie

    2016-01-01

    Class III myosins (Myo3) and actin-bundling protein Espin play critical roles in regulating the development and maintenance of stereocilia in vertebrate hair cells, and their defects cause hereditary hearing impairments...

  18. Bundling Post-Acute Care Services into MS-DRG Payments

    Data.gov (United States)

    U.S. Department of Health & Human Services — A bundled hospital payment system that encompasses both acute and post-acute care has been proposed as a means of creating financial incentives in the Medicare...

  19. Electron Transfer Activity of a de Novo Designed Copper Center in a Three-Helix Bundle Fold

    Science.gov (United States)

    Plegaria, Jefferson S.; Herrero, Christian; Quaranta, Annamaria; Pecoraro, Vincent L.

    2017-01-01

    In this work, we characterized the intermolecular ET property of a de novo designed metallopeptide using laser-flash photolysis. α3D-CH3 is three-helix bundle peptide that was designed to contain a copper ET site found in the β-barrel fold of native cupredoxins. The ET activity of Cuα3D-CH3 was determined using five different photosensitizers. By exhibiting a complete depletion of the photo-oxidant and the successive formation of a Cu(II) species at 400 nm, the transient and generated spectra demonstrated an ET transfer reaction between the photo-oxidant and Cu(I)α3D-CH3. This observation illustrated our success in integrating an ET center within a de novo designed scaffold. From the kinetic traces at 400 nm, first-order and bimolecular rate constants of 105 s−1 and 108 M−1 s−1 were derived. Moreover, a Marcus equation analysis on the rate versus driving force study produced a reorganization energy of 1.1 eV, demonstrating that the helical fold of α3D requires further structural optimization to efficiently perform ET. PMID:26427552

  20. Peptide vectors for gene delivery: from single peptides to multifunctional peptide nanocarriers.

    Science.gov (United States)

    Raad, Markus de; Teunissen, Erik A; Mastrobattista, Enrico

    2014-07-01

    The therapeutic use of nucleic acids relies on the availability of sophisticated delivery systems for targeted and intracellular delivery of these molecules. Such a gene delivery should possess essential characteristics to overcome several extracellular and intracellular barriers. Peptides offer an attractive platform for nonviral gene delivery, as several functional peptide classes exist capable of overcoming these barriers. However, none of these functional peptide classes contain all the essential characteristics required to overcome all of the barriers associated with successful gene delivery. Combining functional peptides into multifunctional peptide vectors will be pivotal for improving peptide-based gene delivery systems. By using combinatorial strategies and high-throughput screening, the identification of multifunctional peptide vectors will accelerate the optimization of peptide-based gene delivery systems.

  1. [Biosynthesis of opioid peptides].

    Science.gov (United States)

    Rossier, J

    1988-01-01

    The endogenous opioid peptides all contain the enkephalin sequence Tyr-Gly-Gly-Phe-Met and Tyr-Gly-Gly-Phe-Leu at their aminoterminus. Three distinct families of these peptides (endorphins, enkephalins and dynorphins) are present in different neuronal pathways within the central nervous system. Molecular genetics have shown that these three families of opioid peptides are derived from three distinct precursors. Pro-opiomelanocortin gives rise to the endorphins, as well as adrenocorticotropic hormone (ACTH) and the melanotropic hormones (MSH's). [Met] enkephalin, [Leu] enkephalin and the related heptapeptide [Met] enkephalin-Arg6-Phe7 and octapeptide [Met] enkephalin-Arg6-Gly7-Leu8 are derived from proenkephalin. The third family is derived from prodynorphin and includes dynorphin A, dynorphin B (also known as rimorphin) and alpha- and beta-neo-endorphin. The structure of the genes coding for these precursors are similar, suggesting the possibility of one common ancestral gene. The most common scheme for enzymatic maturation of precursors proposes the action of a trypsin-like endopeptidase followed by a carboxypeptidase B-like exopeptidase. However, we have provided evidence that this combination of trypsin-like and carboxypeptidase B-like enzymes may not be the only mechanism for liberating enkephalin from low molecular weight enkephalin-containing peptides. Indeed, endo-oligopeptidase A, an enzyme, known to hydrolyze the Phe5-Ser6 bond of bradykinin and the Arg8-Arg9 bond of neurotensin, has been shown to produce, by a single cleavage, [Leu] enkephalin or [Met] enkephalin from small enkephalin-containing peptides, (Camargo et al., 1987, J. Neurochem. 48, 1258-1263).(ABSTRACT TRUNCATED AT 250 WORDS)

  2. Antagonistic peptide technology for functional dissection of CLE peptides revisited.

    Science.gov (United States)

    Czyzewicz, Nathan; Wildhagen, Mari; Cattaneo, Pietro; Stahl, Yvonne; Pinto, Karine Gustavo; Aalen, Reidunn B; Butenko, Melinka A; Simon, Rüdiger; Hardtke, Christian S; De Smet, Ive

    2015-08-01

    In the Arabidopsis thaliana genome, over 1000 putative genes encoding small, presumably secreted, signalling peptides can be recognized. However, a major obstacle in identifying the function of genes encoding small signalling peptides is the limited number of available loss-of-function mutants. To overcome this, a promising new tool, antagonistic peptide technology, was recently developed. Here, this antagonistic peptide technology was tested on selected CLE peptides and the related IDA peptide and its usefulness in the context of studies of peptide function discussed. Based on the analyses, it was concluded that the antagonistic peptide approach is not the ultimate means to overcome redundancy or lack of loss-of-function lines. However, information collected using antagonistic peptide approaches (in the broad sense) can be very useful, but these approaches do not work in all cases and require a deep insight on the interaction between the ligand and its receptor to be successful. This, as well as peptide ligand structure considerations, should be taken into account before ordering a wide range of synthetic peptide variants and/or generating transgenic plants. © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology.

  3. Impact of VAP bundle adherence among ventilated critically ill patients and its effectiveness in adult ICU

    Directory of Open Access Journals (Sweden)

    Saad Rabie Samra

    2017-01-01

    Conclusion: The application of VAP bundle is a feasible reality that produces improvement in microbiological measures and nosocomal infection rates resulting in lowering mortality, shortened lengths of hospitalization and decreased medical care costs. However, education and periodic training remain a fundamental process of improving health services. VAPs were reduced by improving bundle compliance and ensuring the same standard of care to all ICU patients. Direct, on-site observation was a more accurate method of monitoring.

  4. An Exploration of Human Well-Being Bundles as Identifiers of Ecosystem Service Use Patterns.

    Directory of Open Access Journals (Sweden)

    Maike Hamann

    Full Text Available We take a social-ecological systems perspective to investigate the linkages between ecosystem services and human well-being in South Africa. A recent paper identified different types of social-ecological systems in the country, based on distinct bundles of ecosystem service use. These system types were found to represent increasingly weak direct feedbacks between nature and people, from rural "green-loop" communities to urban "red-loop" societies. Here we construct human well-being bundles and explore whether the well-being bundles can be used to identify the same social-ecological system types that were identified using bundles of ecosystem service use. Based on national census data, we found three distinct well-being bundle types that are mainly characterized by differences in income, unemployment and property ownership. The distribution of these well-being bundles approximates the distribution of ecosystem service use bundles to a substantial degree: High levels of income and education generally coincided with areas characterised by low levels of direct ecosystem service use (or red-loop systems, while the majority of low well-being areas coincided with medium and high levels of direct ecosystem service use (or transition and green-loop systems. However, our results indicate that transformations from green-loop to red-loop systems do not always entail an immediate improvement in well-being, which we suggest may be due to a time lag between changes in the different system components. Using human well-being bundles as an indicator of social-ecological dynamics may be useful in other contexts since it is based on socio-economic data commonly collected by governments, and provides important insights into the connections between ecosystem services and human well-being at policy-relevant sub-national scales.

  5. Permanent His Bundle Pacing in Intra-Hisian Conduction Block: Mechanistic Insights.

    Science.gov (United States)

    Herweg, Bengt; Gerczuk, Paul Z; Sofi, Aamir; Vijayaraman, Pugazhendhi; Barold, S Serge

    2017-06-09

    We are reporting a patient with discrete intra-His conduction block and describe a refined technique of permanent His bundle pacing assuring reliable ventricular capture. Meticulous mapping of the site of block with lead placement distal to the site of block and non-selective His bundle pacing with local myocardial capture as an additional safety back up appears to be the technique of choice. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. Fighting Capital Flight in Africa: Evidence from Bundling and Unbundling Governance

    OpenAIRE

    Asongu, Simplice; Nwachukwu, Jacinta

    2016-01-01

    This study investigates the effect of governance on capital flight by bundling and unbundling governance. The empirical evidence is based on 37 African countries for the period 1996-2010 and the Generalised Method of Moments. Governance is bundled by principal component analysis, namely: (i) political governance from political stability and ‘voice and accountability’; (ii) economic governance from government effectiveness and regulation quality and (iii) institutional governance from corrupti...

  7. Time evolution of damage due to environmentally assisted aging in a fiber bundle model

    OpenAIRE

    Lennartz-Sassinek, Sabine; Main, Ian G.; Danku Zsuzsa (1984-) (fizikus); Kun Ferenc (1966-) (fizikus)

    2013-01-01

    Damage growth in composite materials is a complex process which is of interest in many fields of science and engineering. We consider this problem in a fiber bundle model where fibers undergo an aging process due to the accumulation of damage driven by the locally acting stress in a chemically active environment. By subjecting the bundle to a constant external load, fibers fail either when the load on them exceeds their individual intrinsic strength or when the accumulated internal damage exc...

  8. Model for subchannel friction factors and flow redistribution in wire-wrapped rod bundles

    OpenAIRE

    Carajilescov, Pedro; Fernandez y Fernandez, Elói

    1999-01-01

    The fuel element of LMFBR consists of a bundle of rods wrapped with an helical wire as spacer, surrounded by an hexagonal duct. In the present work, a semi-empirical model is developed to calculate bundle average and subchannel based friction factors and flow redistribution. The obtained results were compared to experimental data and they were considered satisfactory for wide range of geometrical parameters.

  9. Rate-Dependent Left Bundle-Branch Block in a Child With Propionic Aciduria

    Science.gov (United States)

    Ardoin, Kipp B.; Moodie, Douglas S.; Snyder, Christopher S.

    2009-01-01

    In most cases, a left bundle-branch block pattern on an electrocardiogram is a postoperative phenomenon. Under rare circumstances, it can be found in patients after myocardial infarction or in patients with hypertrophic cardiomyopathy, or it can be exercised induced. We describe a pediatric patient with propionic aciduria, dilated cardiomyopathy, and rate-dependent left bundle-branch block on her electrocardiogram. PMID:21603417

  10. Right bundle branch block pattern in right ventricular endocardial pacing: A needless concern?

    Directory of Open Access Journals (Sweden)

    Mangalachulli Pottammal Ranjith

    2013-01-01

    Full Text Available Right ventricular (RV endocardial pacing in permanent pacemaker implantation usually yields a left bundle branch block (LBBB pattern in surface electrocardiogram (ECG. The presence of right bundle branch block (RBBB pattern raises the suspicion of lead perforation. We report a case of RV endocardial permanent pacemaker implantation showing a RBBB pattern in ECG, suggesting a complication. However, further work-up revealed that the lead was appropriately located at the RV apex.

  11. Force Generation by Molecular-Motor-Powered Microtubule Bundles; Implications for Neuronal Polarization and Growth.

    Science.gov (United States)

    Jakobs, Maximilian; Franze, Kristian; Zemel, Assaf

    2015-01-01

    The heavily cross-linked microtubule (MT) bundles found in neuronal processes play a central role in the initiation, growth and maturation of axons and dendrites; however, a quantitative understanding of their mechanical function is still lacking. We here developed computer simulations to investigate the dynamics of force generation in 1D bundles of MTs that are cross-linked and powered by molecular motors. The motion of filaments and the forces they exert are investigated as a function of the motor type (unipolar or bipolar), MT density and length, applied load, and motor connectivity. We demonstrate that only unipolar motors (e.g., kinesin-1) can provide the driving force for bundle expansion, while bipolar motors (e.g., kinesin-5) oppose it. The force generation capacity of the bundles is shown to depend sharply on the fraction of unipolar motors due to a percolation transition that must occur in the bundle. Scaling laws between bundle length, force, MT length and motor fraction are presented. In addition, we investigate the dynamics of growth in the presence of a constant influx of MTs. Beyond a short equilibration period, the bundles grow linearly in time. In this growth regime, the bundle extends as one mass forward with most filaments sliding with the growth velocity. The growth velocity is shown to be dictated by the inward flux of MTs, to inversely scale with the load and to be independent of the free velocity of the motors. These findings provide important molecular-level insights into the mechanical function of the MT cytoskeleton in normal axon growth and regeneration after injury.

  12. The Effects of Resource Bundling on Third-party Logistics Providers’ Performance

    OpenAIRE

    Noorliza Karia; Chee Yew Wong; Muhammad Hasmi Abu Hassan Asaari; Kee-hung Lai

    2015-01-01

    This research develops and tests a model of the effects of resources bundling on third-party logistics (3PL) providers’ performance. Based on data from a survey of Malaysian 3PLs, basic and advanced technology and equipment resources, knowledge and relational resources, and demand management interfaces are identified. The bundling of advanced technology, knowledge resources, and demand management interface capability are found to enhance 3PLs’ customer service innovation. Similar resource ...

  13. Fluid mixing studies in a hexagonal 61-pin, wire-wrapped rod bundle

    Energy Technology Data Exchange (ETDEWEB)

    Hanson, A S; Todreas, N

    1977-08-01

    Two wire-wrapped rod bundles with different leads (6 in. and 12 in.) were constructed with geometric parameters similar to proposed LMFBR fuel assemblies. Rod diameter was 0.25 in. and pitch-to-diameter ratio was 1.26. These two bundles were tested in a flow loop which was designed and built for mixing experiments. Fluid mixing was studied by means of salt tracer dispersion. Salt was injected at various radial and axial locations in the bundle via injection rods, and then the dispersed distribution was measured at the bundle exit by means of 126 specially designed electrical conductivity probes inserted into the bundle subchannels. The data collected showed a strong swirl flow around the bundle circumference and periodic variation with axial injection location. Data from turbulent runs was generally good with mass balances averaging 90% and having a spread of +- 25%. The laminar data collected was generally poor because of a ''striping'' phenomena and injection instabilities. Data were compared with calculations using the ENERGY computer code. The comparison between ENERGY calculations and the data was not good for laminar flow and was only fair in the turbulent cases. It was found that turbulent data could be best characterized by the ENERGY parameters C/sub 1/ = 0.19 and epsilon/sub 1/* = 0.025 when the lead was 6 inches; for a 12-inch lead the parameters were C/sub 1/ = 0.16 and epsilon/sub 1/* = 0.012. Pressure drop data was also taken from the two bundles and it too showed a periodic variation with axial location. Friction factors derived from the data were generally higher than predicted by available correlations. These data suggested that traditional flow split calculations could be in error and that the laminar-turbulent transition occurs over a broad Reynolds number range in wire-wrapped rod bundles.

  14. 10D massive type IIA supergravities as the uplift of parabolic M2-brane torus bundles

    Energy Technology Data Exchange (ETDEWEB)

    Garcia del Moral, Maria Pilar [Universidad de Antofagasta (Chile). Dept. de Fisica; Restuccia, Alvaro [Universidad de Antofagasta (Chile). Dept. de Fisica; Universidad Simon Bolivar, Caracas (Venezuela, Bolivarian Republic of). Dept. de Fisica

    2016-04-15

    We remark that the two 10D massive deformations of the N = 2 maximal type IIA supergravity (Romans and HLW supergravity) are associated to the low energy limit of the uplift to 10D of M2-brane torus bundles with parabolic monodromy linearly and non-linearly realized respectively. Romans supergravity corresponds to M2-brane compactified on a twice-punctured torus bundle. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  15. The Intermediate Jacobian of a Three-Dimensional Conic Bundle is a Prym Variety

    Science.gov (United States)

    Èndryushka, S. Yu

    1985-02-01

    The paper contains the computation of the intermediate Jacobian of the general conic bundle. This computation is performed in three steps: a) computation of the Betti number (§2), b) computation of the Jacobian to within isogeny (§4), and c) computation of the polarization (§4).The author's results conclude the study of the intermediate Jacobian of conic bundles and give an efficient general answer.Bibliography: 6 titles.

  16. Description of the attachment geometry of the anteromedial and posterolateral bundles of the ACL from arthroscopic perspective for anatomical tunnel placement.

    NARCIS (Netherlands)

    Luites, J.W.H.; Wymenga, A.B.; Blankevoort, L.; Kooloos, J.G.M.

    2007-01-01

    The anterior cruciate ligament (ACL) consists of an anteromedial bundle (AMB) and a posterolateral bundle (PLB). A reconstruction restoring the functional two-bundled nature should be able to approximate normal ACL function better than the most commonly used single-bundle reconstructions. Accurate

  17. Description of the attachment geometry of the anteromedial and posterolateral bundles of the ACL from arthroscopic perspective for anatomical tunnel placement

    NARCIS (Netherlands)

    Luites, Joan W. H.; Wymenga, Ate B.; Blankevoort, Leendert; Kooloos, Jan G. M.

    2007-01-01

    The anterior cruciate ligament (ACL) consists of an anteromedial bundle (AMB) and a posterolateral bundle (PLB). A reconstruction restoring the functional two-bundled nature should be able to approximate normal ACL function better than the most commonly used single-bundle reconstructions. Accurate

  18. Bundled payments for care improvement initiative: the next evolution of payment formulations: AAHKS Bundled Payment Task Force.

    Science.gov (United States)

    Froimson, Mark I; Rana, Adam; White, Richard E; Marshall, Amanda; Schutzer, Steve F; Healy, William L; Naas, Peggy; Daubert, Gail; Iorio, Richard; Parsley, Brian

    2013-09-01

    The Patient Protection and Affordable Care Act contains a number of provision for improving the delivery of healthcare in the United States, among the most impactful of which may be the call for modifications in the packaging of and payment for care that is bundled into episodes. The move away from fee for service payment models to payment for coordinated care delivered as comprehensive episodes is heralded as having great potential to enhance quality and reduce cost, thereby increasing the value of the care delivered. This effort builds on the prior experience around delivering care for arthroplasty under the Acute Care Episode Project and offers extensions and opportunities to modify the experience moving forward. Total hip and knee arthroplasties are viewed as ideal treatments to test the effectiveness of this payment model. Providers must learn the nuances of these modified care delivery concepts and evaluate whether their environment is conducive to success in this arena. This fundamental shift in payment for care offers both considerable risk and tremendous opportunity for physicians. Acquiring an understanding of the recent experience and the determinants of future success will best position orthopaedic surgeons to thrive in this new environment. Although this will remain a dynamic exercise for some time, early experience may enhance the chances for long term success, and physicians can rightfully lead the care delivery redesign process. © 2013 Elsevier Inc. All rights reserved.

  19. Cardiac memory during rather than after termination of left bundle branch block.

    Science.gov (United States)

    Littmann, Laszlo; Proctor, Patrick A; Givens, Priscilla M

    2014-01-01

    An 83-year-old woman with chronic left bundle branch block and remote history of pacemaker implantation for intermittent AV block was hospitalized for fatigue and leg swelling. She had no cardiac complaints. Routine 12-lead electrocardiogram showed sinus rhythm with left bundle branch block. There were diffuse negative T waves in the inferior and anterolateral leads that were concordant with the QRS complexes. Echocardiogram was normal and nuclear perfusion heart scan showed no abnormality. It was noted that the negative T waves during left bundle branch block were in the exact same leads as were the deep negative QRS complexes during ventricular pacing. The electrocardiographic changes were consistent with cardiac memory. This case is unique because cardiac memory in patients with intermittent left bundle branch block typically occurs when the QRS complexes normalize and not during left bundle branch block itself. Our findings indicate that memory Ts can develop not only after normalization of wide complex rhythms but also with alternating wide complex rhythms as in the presented case where a ventricular paced rhythm was replaced by left bundle branch block. Copyright © 2014 Elsevier Inc. All rights reserved.

  20. 10 years with slash bundles. More efficiency and flexibility to forest energy logistics

    Energy Technology Data Exchange (ETDEWEB)

    Kilponen, M. (John Deere Forestry Oy, Tampere (Finland)), e-mail: Kilponen.MaricaA@JohnDeere.com

    2010-07-01

    John Deere Forestry introduced its first slash bundler TJ1490D to the market in 2002. Bioenergy market was developing rapidly especially in Finland during the first two years, and bundling method was taken in use in several other European countries. Thereafter, bundler market has been growing constantly in the other countries, but in Finland the development of market has almost come to a stop without any visible change in operations or technology. This has raised interesting question: What are the main differences in the market areas and why are they developing differently? Aim to get better understanding of bundling related business and market differences, all current and former slash bundler customers in Finland and Spain have been interviewed. results of the study show interesting differences in business models, which also have direct relation to the overall profitability. Based on the results it's also obvious that the earlier learning period of using bundles still has a great impact in this method's reputation: moisture of bundles and cutting challenges of twine are still seen as a challenge, even though there are good examples of power plants who have learned how to use bundles in most efficient way. Using bundles as part of logistic solution in biomass supply chain can offer several benefits to the forest energy sector. (orig.)

  1. Properties of the microcirculation in capillary bundles of rat spinotrapezius muscle fascia

    Science.gov (United States)

    Jacobitz, Frank; Engebrecht, Cheryn; Metzger, Ian; Porterfield, Colin

    2006-11-01

    Properties of the microcirculation in capillary bundles of rat spinotrapezius muscle fascia are investigated using microscope observations, empirical modeling, and numerical simulations. Capillary bundles consist of a network of feeding arterioles, draining venules, and capillary vessels. A dozen samples of muscle fascia tissue were prepared for microscope observation. The chosen method of preparation allows for the long-term preservation of the tissue samples for future studies. Capillary bundles are photographed under a microscope with 40x magnification. From the images, the microvasculature of the tissue samples is reconstructed. It was found, for example, that the distribution of vessel length in a capillary bundle follows a log-normal law. In addition to a statistical analysis of the vessel data, the network topology is used for numerical simulations of the flow in the capillary bundles. The numerical approach uses a sparse-matrix solver and it considers vessel elasticity and blood rheology. The numerical simulations show, for example, a strong pressure drop across the capillary vessels of the bundle.

  2. Fabrication of a CANFLEX-RU designed bundle for power ramp irradiation test in NRU

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Moon Sung

    2000-11-01

    The BDL-443 CANFLEX-RU bundle AKW was fabricated at Korea Atomic Energy Research Institute (KAERI) for power ramp irradiation testing in NRU reactor. The bundle was fabricated with IDR and ADU fuel pellets in adjacent elements and contains fuel pellets enriched to 1.65 wt% {sup 235}U in the outer and intermediate rings and also contains pellets enriched to 2.00 wt% {sup 235}U in the inner ring. This bundle does not have a center element to allow for insertion on a hanger bar. KAERI produced the IDR pellets with the IDR-source UO{sub 2} powder supplied by BNFL. ADU pellets were fabricated and supplied by AECL. Bundle kits (Zircaloy-4 end plates, end plugs, and sheaths with brazed appendages) manufactured at KAERI earlier in 1996 were used for the fabrication of the bundle. The CANFLEX bundle was fabricated successfully at KAERI according to the QA provisions specified in references and as per relevant KAERI drawings and technical specification. This report covers the fabrication activities performed at KAERI. Fabrication processes performed at AECL will be documented in a separate report.

  3. Experimental observation of spatially resolved photo-luminescence intensity distribution in dual mode upconverting nanorod bundles

    Science.gov (United States)

    Kumar, Pawan; Singh, Satbir; Singh, V. N.; Singh, Nidhi; Gupta, R. K.; Gupta, Bipin Kumar

    2017-02-01

    A novel method for demonstration of photoluminescence intensity distribution in upconverting nanorod bundles using confocal microscopy is reported. Herein, a strategy for the synthesis of highly luminescent dual mode upconverting/downshift Y1.94O3:Ho3+0.02/Yb3+0.04 nanorod bundles by a facile hydrothermal route has been introduced. These luminescent nanorod bundles exhibit strong green emission at 549 nm upon excitations at 449 nm and 980 nm with quantum efficiencies of ~6.3% and ~1.1%, respectively. The TEM/HRTEM results confirm that these bundles are composed of several individual nanorods with diameter of ~100 nm and length in the range of 1-3 μm. Furthermore, two dimensional spatially resolved photoluminescence intensity distribution study has been carried out using confocal photoluminescence microscope throughout the nanorod bundles. This study provides a new direction for the potential use of such emerging dual mode nanorod bundles as photon sources for next generation flat panel optical display devices, bio-medical applications, luminescent security ink and enhanced energy harvesting in photovoltaic applications.

  4. Deconstructing the infection control bundles for the containment of carbapenem-resistant Enterobacteriaceae.

    Science.gov (United States)

    Munoz-Price, L Silvia; Quinn, John P

    2013-08-01

    Rates of carbapenem-resistant Enterobacteriaceae (CRE), especially Klebsiella pneumoniae carbapenemase (KPC)-producing Gram-negatives, have increased worldwide. Infections caused by these organisms have been associated with a high mortality, which might be due in part to the limited availability of antibiotic options. Therefore, prevention of acquisition of these organisms is essential. This review summarizes published infection control interventions (bundles) that have been implemented for the control of outbreaks caused by KPC-producing organisms. A total of 15 bundles of interventions aimed at controlling CRE outbreaks are presented. The interventions included combinations of increased compliance with hand hygiene and contact precautions, environmental cleaning, early identification of asymptomatic carriers, and physical separation of CRE-positive patients and their staff. Three bundles had staggered implementation of interventions with their later phase involving a combination of rectal surveillance cultures for identification of asymptomatic CRE carriers, cohorting of CRE-positive patients, and cohorting of the staff caring for CRE carriers. All three staggered bundles successfully decreased their CRE acquisition rates after implementation of their later phases. Bundles combine multiple interventions targeting different levels of the transmission pathways and most include increased hand hygiene and contact precautions. However, bundles implemented in phases would seem to indicate that active surveillance cultures and the subsequent cohorting of patients and staff based on these results might be particularly beneficial for controlling horizontal transmission.

  5. Self-assembly of coiled coil peptides into nanoparticles vs 2-d plates: effects of assembly pathway

    Science.gov (United States)

    Kim, Kyunghee; Pochan, Darrin

    Molecular solution assembly, or self-assembly, is a process by which ordered nanostructures or patterns are formed by non-covalent interactions during assembly. Biomimicry, the use of bioinspired molecules or biologically relevant materials, is an important area of self-assembly research with peptides serving a critical role as molecular tools. The morphology of peptide assemblies can be controlled by adjusting solution conditions such as the concentration of peptides, the temperature, and pH. Herein, spherical nanostructures, which have potential for creating an encapsulation system, are formed by self-assembly when coiled coil peptides are combined in solution. These peptides are homotrimeric and heterodimeric coiled-coil bundles and the homotrimer is connected with each of heterodimer through their external surfaces via disulfide bonds. The resultant covalent constructs could co-assemble into complementary trimeric hubs, respectively. The two peptide constructs are directly mixed and assembled in solution in order to produce either spherical particles or 2-d plates depending on the solution conditions and kinetic pathway of assembly. In particular, structural changes of the self-assembled peptides are explored by control of the thermal history of the assembly solution.

  6. Radiolabelled peptides for oncological diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Laverman, Peter; Boerman, Otto C.; Oyen, Wim J.G. [Radboud University Nijmegen Medical Centre, Department of Nuclear Medicine, Nijmegen (Netherlands); Sosabowski, Jane K. [Queen Mary University of London, Centre for Molecular Oncology, Barts Cancer Institute, London (United Kingdom)

    2012-02-15

    Radiolabelled receptor-binding peptides targeting receptors (over)expressed on tumour cells are widely under investigation for tumour diagnosis and therapy. The concept of using radiolabelled receptor-binding peptides to target receptor-expressing tissues in vivo has stimulated a large body of research in nuclear medicine. The {sup 111}In-labelled somatostatin analogue octreotide (OctreoScan trademark) is the most successful radiopeptide for tumour imaging, and was the first to be approved for diagnostic use. Based on the success of these studies, other receptor-targeting peptides such as cholecystokinin/gastrin analogues, glucagon-like peptide-1, bombesin (BN), chemokine receptor CXCR4 targeting peptides, and RGD peptides are currently under development or undergoing clinical trials. In this review, we discuss some of these peptides and their analogues, with regard to their potential for radionuclide imaging of tumours. (orig.)

  7. Multidimensional Design of Anticancer Peptides.

    Science.gov (United States)

    Lin, Yen-Chu; Lim, Yi Fan; Russo, Erica; Schneider, Petra; Bolliger, Lea; Edenharter, Adriana; Altmann, Karl-Heinz; Halin, Cornelia; Hiss, Jan A; Schneider, Gisbert

    2015-08-24

    The computer-assisted design and optimization of peptides with selective cancer cell killing activity was achieved through merging the features of anticancer peptides, cell-penetrating peptides, and tumor-homing peptides. Machine-learning classifiers identified candidate peptides that possess the predicted properties. Starting from a template amino acid sequence, peptide cytotoxicity against a range of cancer cell lines was systematically optimized while minimizing the effects on primary human endothelial cells. The computer-generated sequences featured improved cancer-cell penetration, induced cancer-cell apoptosis, and were enabled a decrease in the cytotoxic concentration of co-administered chemotherapeutic agents in vitro. This study demonstrates the potential of multidimensional machine-learning methods for rapidly obtaining peptides with the desired cellular activities. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Electrical remodelling in patients with iatrogenic left bundle branch block.

    Science.gov (United States)

    Engels, Elien B; Poels, Thomas T; Houthuizen, Patrick; de Jaegere, Peter P T; Maessen, Jos G; Vernooy, Kevin; Prinzen, Frits W

    2016-12-01

    Left bundle branch block (LBBB) is induced in approximately one-third of all transcatheter aortic valve implantation (TAVI) procedures. We investigated electrophysiological remodelling in patients with TAVI-induced LBBB. This retrospective study comprises 107 patients with initially narrow QRS complex of whom 40 did not and 67 did develop persistent LBBB after TAVI. 12-lead electrocardiograms (ECGs) taken before TAVI, within 24 hours ('acute'), and 1-12 months after TAVI ('chronic') were used to reconstruct vectorcardiograms. From these vectorcardiograms, QRS and T-wave area were calculated as comprehensive indices of depolarization and repolarization abnormalities, respectively. TAVI-induced LBBB resulted in significant acute depolarization and repolarization changes while further repolarization changes were observed with longer lasting LBBB. The amount of long-term repolarization changes (remodelling) was highly variable between patients. The change in T-wave area between acute and chronic LBBB ranged from +57% to - 77%. After dividing the LBBB cohort into tertiles based on the change in T-wave area, only baseline QRS area was larger in the tertile with no significant change in T-wave area. During longer lasting LBBB, the spatial vector gradient (SVG) changed orientation towards the direction of the QRS-vector, indicating that later-activated regions developed shorter action potential duration. This study in patients with TAVI-induced LBBB shows that repolarization changes develop within months after onset of LBBB, and that these changes are highly variable between individual patients. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For Permissions, please email: journals.permissions@oup.com.

  9. Fiber bundle probes for interconnecting miniaturized medical imaging devices

    Science.gov (United States)

    Zamora, Vanessa; Hofmann, Jens; Marx, Sebastian; Herter, Jonas; Nguyen, Dennis; Arndt-Staufenbiel, Norbert; Schröder, Henning

    2017-02-01

    Miniaturization of medical imaging devices will significantly improve the workflow of physicians in hospitals. Photonic integrated circuit (PIC) technologies offer a high level of miniaturization. However, they need fiber optic interconnection solutions for their functional integration. As part of European funded project (InSPECT) we investigate fiber bundle probes (FBPs) to be used as multi-mode (MM) to single-mode (SM) interconnections for PIC modules. The FBP consists of a set of four or seven SM fibers hexagonally distributed and assembled into a holder that defines a multicore connection. Such a connection can be used to connect MM fibers, while each SM fiber is attached to the PIC module. The manufacturing of these probes is explored by using well-established fiber fusion, epoxy adhesive, innovative adhesive and polishing techniques in order to achieve reliable, low-cost and reproducible samples. An innovative hydrofluoric acid-free fiber etching technology has been recently investigated. The preliminary results show that the reduction of the fiber diameter shows a linear behavior as a function of etching time. Different etch rate values from 0.55 μm/min to 2.3 μm/min were found. Several FBPs with three different type of fibers have been optically interrogated at wavelengths of 630nm and 1550nm. Optical losses are found of approx. 35dB at 1550nm for FBPs composed by 80μm fibers. Although FBPs present moderate optical losses, they might be integrated using different optical fibers, covering a broad spectral range required for imaging applications. Finally, we show the use of FBPs as promising MM-to-SM interconnects for real-world interfacing to PIC's.

  10. Design and impact of bundled payment for detox and follow-up care.

    Science.gov (United States)

    Quinn, Amity E; Hodgkin, Dominic; Perloff, Jennifer N; Stewart, Maureen T; Brolin, Mary; Lane, Nancy; Horgan, Constance M

    2017-11-01

    Recent payment reforms promote movement from fee-for-service to alternative payment models that shift financial risk from payers to providers, incentivizing providers to manage patients' utilization. Bundled payment, an episode-based fixed payment that includes the prices of a group of services that would typically treat an episode of care, is expanding in the United States. Bundled payment has been recommended as a way to pay for comprehensive SUD treatment and has the potential to improve treatment engagement after detox, which could reduce detox readmissions, improve health outcomes, and reduce medical care costs. However, if moving to bundled payment creates large losses for some providers, it may not be sustainable. The objective of this study was to design the first bundled payment for detox and follow-up care and to estimate its impact on provider revenues. Massachusetts Medicaid beneficiaries' behavioral health, medical, and pharmacy claims from July 2010-April 2013 were used to build and test a detox bundled payment for continuously enrolled adults (N=5521). A risk adjustment model was developed using general linear modeling to predict beneficiaries' episode costs. The projected payments to each provider from the risk adjustment analysis were compared to the observed baseline costs to determine the potential impact of a detox bundled payment reform on organizational revenues. This was modeled in two ways: first assuming no change in behavior and then assuming a supply-side cost sharing behavioral response of a 10% reduction in detox readmissions and an increase of one individual counseling and one group counseling session. The mean total 90-day detox episode cost was $3743. Nearly 70% of the total mean cost consists of the index detox, psychiatric inpatient care, and short-term residential care. Risk mitigation, including risk adjustment, substantially reduced the variation of the mean episode cost. There are opportunities for organizations to gain revenue

  11. Reconstruction of the anterior cruciate ligament : a clinical comparison of bone-patellar tendon-bone single bundle versus semitendinosus and gracilis double bundle technique

    NARCIS (Netherlands)

    Sadoghi, Patrick; Mueller, Peter E.; Jansson, Volkmar; van Griensven, Martin; Kroepfl, Albert; Fischmeister, Martin F.

    The study hypothesis was that the outcome of semitendinosus gracilis double bundle (STG-DB) anterior cruciate ligament (ACL) reconstruction is advantageous in terms of clinical results and restoration of anterior-posterior and rotational laxity in comparison to bone-patellar tendon-bone

  12. Calculation on a tube bundle: change in bundle stiffness; Calcul sur un faisceau de tubes: changement de raideur au sein du faisceau

    Energy Technology Data Exchange (ETDEWEB)

    Goasdoue, J

    1998-06-01

    Tube bundles immersed in a fluid are frequently used in nuclear equipment like reactor core. In this work, tubes have not the same stiffness. The aim of this study is then to analyze the influence of stiffness on the structure behaviour. The CASTEM 2000 code has been used. (O.M.)

  13. Antimicrobial Peptides (AMPs

    Directory of Open Access Journals (Sweden)

    Mehrzad Sadredinamin

    2016-04-01

    Full Text Available Antimicrobial peptides (AMPs are extensive group of molecules that produced by variety tissues of invertebrate, plants, and animal species which play an important role in their immunity response. AMPs have different classifications such as; biosynthetic machines, biological sources, biological functions, molecular properties, covalent bonding patterns, three dimensional structures, and molecular targets.These molecules have multidimensional properties including antimicrobial activity, antiviral activity, antifungal activity, anti-parasite activity, biofilm control, antitumor activity, mitogens activity and linking innate to adaptive immunity that making them promising agents for therapeutic drugs. In spite of this advantage of AMPs, their clinical developments have some limitation for commercial development. But some of AMPs are under clinical trials for the therapeutic purpose such as diabetic foot ulcers, different bacterial infections and tissue damage. In this review, we emphasized on the source, structure, multidimensional properties, limitation and therapeutic applications of various antimicrobial peptides.

  14. Antimicrobial peptides in annelids

    OpenAIRE

    Tasiemski, A.

    2008-01-01

    Gene encoded antimicrobial peptides (AMPs) are widely distributed among living organisms including plants, invertebrates and vertebrates. They constitute important effectors of the innate immune response by exerting multiple roles as mediators of inflammation with impact on epithelial and inflammatory cells influencing diverse processes such as cytokine release, cell proliferation, angiogenesis, wound healing, chemotaxis and immune induction. In invertebrates, most of the data describe the ch...

  15. Effect of the Maximum Dose on White Matter Fiber Bundles Using Longitudinal Diffusion Tensor Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Tong; Chapman, Christopher H. [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States); Tsien, Christina [Department of Radiation Oncology, Washington University at St Louis, St Louis, Missouri (United States); Kim, Michelle; Spratt, Daniel E.; Lawrence, Theodore S. [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States); Cao, Yue, E-mail: yuecao@umich.edu [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States); Department of Radiology, University of Michigan, Ann Arbor, Michigan (United States); Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan (United States)

    2016-11-01

    Purpose: Previous efforts to decrease neurocognitive effects of radiation focused on sparing isolated cortical structures. We hypothesize that understanding temporal, spatial, and dosimetric patterns of radiation damage to whole-brain white matter (WM) after partial-brain irradiation might also be important. Therefore, we carried out a study to develop the methodology to assess radiation therapy (RT)–induced damage to whole-brain WM bundles. Methods and Materials: An atlas-based, automated WM tractography analysis was implemented to quantify longitudinal changes in indices of diffusion tensor imaging (DTI) of 22 major WM fibers in 33 patients with predominantly low-grade or benign brain tumors treated by RT. Six DTI scans per patient were performed from before RT to 18 months after RT. The DTI indices and planned doses (maximum and mean doses) were mapped onto profiles of each of 22 WM bundles. A multivariate linear regression was performed to determine the main dose effect as well as the influence of other clinical factors on longitudinal percentage changes in axial diffusivity (AD) and radial diffusivity (RD) from before RT. Results: Among 22 fiber bundles, AD or RD changes in 12 bundles were affected significantly by doses (P<.05), as the effect was progressive over time. In 9 elongated tracts, decreased AD or RD was significantly related to maximum doses received, consistent with a serial structure. In individual bundles, AD changes were up to 11.5% at the maximum dose locations 18 months after RT. The dose effect on WM was greater in older female patients than younger male patients. Conclusions: Our study demonstrates for the first time that the maximum dose to the elongated WM bundles causes post-RT damage in WM. Validation and correlative studies are necessary to determine the ability and impact of sparing these bundles on preserving neurocognitive function after RT.

  16. Right bundle branch block as a marker for interatrial septal abnormalities.

    Science.gov (United States)

    Bakalli, Aurora; Koçinaj, Dardan; Georgievska-Ismail, Ljubica; Bekteshi, Tefik; Pllana, Ejup; Sejdiu, Basri

    2012-02-01

    Interatrial septal anomalies, which include atrial septal defect, patent foramen ovale, and atrial septal aneurysm, are common disorders among adult patients. Early detection of interatrial septal anomalies is important in order to prevent haemodynamic consequences and/or thromboembolic events. Electrocardiogram offers some clues that should serve as hints for detection of interatrial abnormalities. The aim of our study was to analyse the interatrial septum by transoesophageal echocardiography in patients with electrocardiogram signs of right bundle branch block and in those without right bundle branch block. In a prospective study, 87 adult patients were included, that is, 41 with electrocardiogram signs of right bundle branch block forming the first group and 46 without right bundle branch block forming the second group. Interatrial septal anomalies were present in 80.5% of the patients with right bundle branch block, with patent foramen ovale (39.02%) being the most prevalent disorder, followed by atrial septal aneurysm (21.9%) and atrial septal defect (19.5%). Interatrial septal abnormalities were significantly more frequent in the first group compared with the second group (80.5% versus 6.5%, p value less than 0.001). Independently, patent foramen ovale was significantly more prevalent in patients with right bundle branch block (39.02% versus 4.3%, p value less than 0.001), as were atrial septal aneurysm (21.9% versus 2.2%, p value equal 0.01) and atrial septal defect (19.5% versus 0%, p value equal 0.004). Right bundle branch block should serve as a valuable indicator to motivate a detailed search for interatrial septal abnormalities.

  17. Improving care for patients whose recovery is uncertain. The AMBER care bundle: design and implementation.

    Science.gov (United States)

    Carey, Irene; Shouls, Susanna; Bristowe, Katherine; Morris, Michelle; Briant, Linda; Robinson, Carole; Caulkin, Ruth; Griffiths, Mathew; Clark, Kieron; Koffman, Jonathan; Hopper, Adrian

    2015-12-01

    Despite preferences to the contrary, 53% of deaths in England occur in hospital. Difficulties in managing clinical uncertainty can result in delayed recognition that a person may be approaching the end of life, and a failure to address his/her preferences. Planning and shared decision-making for hospital patients need to improve where an underlying condition responds poorly to acute medical treatment and there is a risk of dying in the next 1-2 months. This paper suggests an approach to improve this care. A care bundle (the AMBER care bundle) was designed by a multiprofessional development team, which included service users, utilising the model for improvement following an initial scoping exercise. The care bundle includes two identification questions, four subsequent time restricted actions and systematic daily follow-up. This paper describes the development and implementation of a care bundle. From August 2011 to July 2012, 638 patients received care supported by the AMBER care bundle. In total 42.8% died in hospital and a further 14.5% were readmitted as emergencies within 30 days of discharge. Clinical outcome measures are in development. It has been possible to develop a care bundle addressing a complex area of care which can be a lever for cultural change. The implementation of the AMBER care bundle has the potential to improve care of clinically uncertain hospital patients who may be approaching the end of life by supporting their recognition and prompting discussion of their preferences. Outcomes associated with its use are currently being formally evaluated. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  18. Project IMPACT Pilot Report: Feasibility of Implementing a Hospital-to-Home Transition Bundle.

    Science.gov (United States)

    Mallory, Leah A; Osorio, Snezana Nena; Prato, B Stephen; DiPace, Jennifer; Schmutter, Lisa; Soung, Paula; Rogers, Amanda; Woodall, William J; Burley, Kayla; Gage, Sandra; Cooperberg, David

    2017-03-01

    To improve hospital to home transitions, a 4-element pediatric patient-centered transition bundle was developed, including: a transition readiness checklist; predischarge teach-back education; timely and complete written handoff to the primary care provider; and a postdischarge phone call. The objective of this study was to demonstrate the feasibility of bundle implementation and report initial outcomes at 4 pilot sites. Outcome measures included postdischarge caregiver ability to teach-back key home management information and 30-day reuse rates. A multisite, observational time series using multiple planned sequential interventions to implement bundle components with non-technology-supported and technology-supported patients. Data were collected via electronic health record reviews and during postdischarge phone calls. Statistical process control charts were used to assess outcomes. Four pilot sites implemented the bundle between January 2014 and May 2015 for 2601 patients, of whom 1394 had postdischarge telephone encounters. Improvement was noted in the implementation of all bundle elements with the transitions readiness checklist posing the greatest feasibility challenge. Phone contact connection rates were 69%. Caregiver ability to teach-back essential home management information postdischarge improved from 18% to 82%. No improvement was noted in reuse rates, which differed dramatically between technology-supported and non-technology-supported patients. A pediatric care transition bundle was successfully tested and implemented, as demonstrated by improvement in all process measures, as well as caregiver home management skills. Important considerations for successful implementation and evaluation of the discharge bundle include the role of local context, electronic health record integration, and subgroup analysis for technology-supported patients. Copyright © 2017 by the American Academy of Pediatrics.

  19. Peptide-enhanced oral delivery of therapeutic peptides and proteins

    DEFF Research Database (Denmark)

    Kristensen, Mie; Foged, Camilla; Berthelsen, Jens

    2013-01-01

    Systemic therapy upon oral delivery of biologics, such as peptide and protein drugs is limited due to their large molecular size, their low enzymatic stability and their inability to cross the intestinal epithelium. Ways to overcome the epithelial barrier include the use of peptide-based excipients...... throughout the gastrointestinal (GI) tract, chemical stability is an inherent challenge when employing amino acid-based excipients for oral delivery, and multiple approaches have been investigated to improve this. The exact mechanisms of transepithelial translocation are discussed, and it is believed...... for oral delivery of peptide and protein drugs highlighting recent studies and the most promising compounds from these classes of peptide excipients....

  20. Splice-site A choice targets plasma-membrane Ca2+-ATPase isoform 2 to hair bundles.

    Science.gov (United States)

    Hill, Jennifer K; Williams, Diane E; LeMasurier, Meredith; Dumont, Rachel A; Strehler, Emanuel E; Gillespie, Peter G

    2006-06-07

    Localization of mechanotransduction in sensory hair cells to hair bundles requires selective targeting of essential proteins to specific locations. Isoform 2 of the plasma-membrane Ca2+-ATPase (PMCA2), required for hearing and balance, is found exclusively in hair bundles. We determined the contribution of splicing at the two major splicing sites (A and C) to hair-cell targeting of PMCA2. When PMCA2 isoforms were immunoprecipitated from purified hair bundles of rat utricle, 2w was the only site A variant detected; moreover, immunocytochemistry for 2w in rat vestibular and cochlear tissues indicated that this splice form was located solely in bundles. To demonstrate the necessity of the 2w sequence, we transfected hair cells with PMCA2 containing different variants at splice sites A and C. Although native hair bundles exclusively use the 2a form at splice-site C, epitope-tagged PMCA2w/a and PMCA2w/b were both concentrated in bundles, indicating that site C is not involved in bundle targeting. In contrast, PMCA2z/a was excluded from bundles and was instead targeted to the basolateral plasma membrane. Bundle-specific targeting of PMCA2w/a tagged with green fluorescent protein (GFP) was diminished, suggesting that GFP interfered with splice-site A. Together, these data demonstrate that PMCA2w/a is the hair-bundle isoform of PMCA in rat hair cells and that 2w targets PMCA2 to bundles. The 2w sequence is thus the first targeting signal identified for a hair-bundle membrane protein; moreover, the striking distribution of inner-ear PMCA isoforms dictated by selective targeting suggests a critical functional role for segregated pathways of Ca2+ transport.

  1. Measurement of the thermal diffusivity of a silica fiber bundle using a laser and an IR camera

    OpenAIRE

    Vignoles, Gérard; BRESSON, Grégory; Lorrette, Christophe; AHMADI-SENICHAULT, Azita

    2012-01-01

    International audience; We propose a lightweight method for the determination of heat diffusivity of silica fiber bundles based on the use of a laser and an IR camera. The fiber bundle is maintained in traction in a holder; exposition is made as a step function, followed by a laser shutdown. The movie obtained by the IR camera is then processed : frame averaging, backgraound computation and substraction, image smoothing, extraction of the IR signal along the fiber bundle. A 1D model has been ...

  2. Dark-field illuminated fiber bundle endoscopy with iterative l1-min image reconstruction for honeycomb pattern removal

    Science.gov (United States)

    Liu, Xuan; Zhang, Lijun; Kirby, Mitchell; Raj, Divyaansh; Qi, Shaohai; Zhao, Feng

    2015-03-01

    In this study, we developed a dark-field illuminated reflectance fiber-optic microscope (DRFM) along with an algorithm for l1-norm minimization of fiber bundle image to provide intrinsic endoscopic imaging with cellular resolution. To suppress specular reflection from fiber bundle facets, we adopted a dark-field configuration. To remove the honeycomb pattern of fiber bundle while preserve image resolution and contrast, we chose to minimize the image l1 norm using iterative shrinkage thresholding (IST) algorithm.

  3. Changing axis deviation with changing bundle branch block and new-onset of atrial fibrillation during acute myocardial infarction.

    Science.gov (United States)

    Patanè, Salvatore; Marte, Filippo; Di Bella, Gianluca

    2009-03-06

    Paroxysmal atrial fibrillation is considered a frequent complication of acute myocardial infarction.It has been rarely reported alternating right and left bundle branch block associated with atrial fibrillation. It has also been rarely reported changing axis deviation with left bundle branch block also during atrial fibrillation and acute myocardial infarction. We present a case of changing axis deviation with changing bundle branch block and new-onset of atrial fibrillation in a 96-year-old Italian man with acute myocardial infarction.

  4. Consensus Bundle on Prevention of Surgical Site Infections After Major Gynecologic Surgery.

    Science.gov (United States)

    Pellegrini, Joseph E; Toledo, Paloma; Soper, David E; Bradford, William C; Cruz, Deborah A; Levy, Barbara S; Lemieux, Lauren A

    2017-02-06

    Surgical site infections are the most common complication of surgery in the United states. Of surgeries in women of reproductive age, hysterectomy is one of the most frequently performed, second only to cesarean birth. Therefore, prevention of surgical site infections in women undergoing gynecologic surgery is an ideal topic for a patient safety bundle. The primary purpose of this safety bundle is to provide recommendations that can be implemented into any surgical environment in an effot to reduce the incidence of surgical site infection. This bundle was developed by a multidisciplinary team convened by the Council on Patient Safety in Women's Health Care. The bundle is organized into four domains: Readiness, Recognition and Prevention, Response, and Reporting and Systems Learning. In addition to recommendations for practice, each of the domains stresses communication and teamwork between all members of the surgical team. Although the bundle components are designed to be adaptable to work in a variety of clinical settings, standardization within institutions is encouraged. Copyright ©2016 American College of Obstetricians and Gynecologists.

  5. Automating Quality Metrics in the Era of Electronic Medical Records: Digital Signatures for Ventilator Bundle Compliance.

    Science.gov (United States)

    Lan, Haitao; Thongprayoon, Charat; Ahmed, Adil; Herasevich, Vitaly; Sampathkumar, Priya; Gajic, Ognjen; O'Horo, John C

    2015-01-01

    Ventilator-associated events (VAEs) are associated with increased risk of poor outcomes, including death. Bundle practices including thromboembolism prophylaxis, stress ulcer prophylaxis, oral care, and daily sedation breaks and spontaneous breathing trials aim to reduce rates of VAEs and are endorsed as quality metrics in the intensive care units. We sought to create electronic search algorithms (digital signatures) to evaluate compliance with ventilator bundle components as the first step in a larger project evaluating the ventilator bundle effect on VAE. We developed digital signatures of bundle compliance using a retrospective cohort of 542 ICU patients from 2010 for derivation and validation and testing of signature accuracy from a cohort of random 100 patients from 2012. Accuracy was evaluated against manual chart review. Overall, digital signatures performed well, with median sensitivity of 100% (range, 94.4%-100%) and median specificity of 100% (range, 100%-99.8%). Automated ascertainment from electronic medical records accurately assesses ventilator bundle compliance and can be used for quality reporting and research in VAE.

  6. Differences in the microstructural properties of the anteromedial and posterolateral bundles of the anterior cruciate ligament.

    Science.gov (United States)

    Skelley, Nathan W; Castile, Ryan M; York, Timothy E; Gruev, Viktor; Lake, Spencer P; Brophy, Robert H

    2015-04-01

    Tissue properties of the anteromedial (AM) and posterolateral (PL) bundles of the anterior cruciate ligament (ACL) have not been previously characterized with real-time dynamic testing. The current study used a novel polarized light technique to measure the material and microstructural properties of the ACL. The AM and PL bundles of the ACL have similar material and microstructural properties. Controlled laboratory study. The AM and PL bundles were isolated from 16 human cadaveric ACLs (11 male, 5 female; average age, 41 years [range, 24-53 years]). Three samples from each bundle were loaded in uniaxial tension, and a custom-built polarized light imaging camera was used to quantify collagen fiber alignment in real time. A bilinear curve fit was applied to the stress-strain data of a quasistatic ramp-to-failure to quantify the moduli in the toe and linear regions. Fiber alignment was quantified at zero strain, the transition point of the bilinear fit, and in the linear portion of the stress-strain curve by computing the degree of linear polarization (DoLP) and angle of polarization (AoP), which are measures of the strength and direction of collagen alignment, respectively. Data were compared using t tests. The AM bundle exhibited significantly larger toe-region (AM 7.2 MPa vs. PL 4.2 MPa; P ligament microstructure can be used to assess graft options for ACL reconstruction and optimize surgical reconstruction techniques. © 2015 The Author(s).

  7. Tau can switch microtubule network organizations: from random networks to dynamic and stable bundles.

    Science.gov (United States)

    Prezel, Elea; Elie, Auréliane; Delaroche, Julie; Stoppin-Mellet, Virginie; Bosc, Christophe; Serre, Laurence; Fourest-Lieuvin, Anne; Andrieux, Annie; Vantard, Marylin; Arnal, Isabelle

    2017-11-22

    In neurons, microtubule networks alternate between single filaments and bundled arrays under the influence of effectors controlling their dynamics and organization. Tau is a microtubule bundler which stabilizes microtubules by stimulating growth and inhibiting shrinkage. The mechanisms by which tau organizes microtubule networks remain poorly understood. Here, we studied the self-organization of microtubules growing in the presence of tau isoforms and mutants. The results show that tau's ability to induce stable microtubule bundles requires two hexapeptides located in its microtubule-binding domain, and is modulated by its projection domain. Site-specific pseudo-phosphorylation of tau promotes distinct microtubule organizations: stable single microtubules, stable bundles or dynamic bundles. Disease-related tau mutations increase the formation of highly dynamic bundles. Finally, cryo-electron microscopy experiments indicate that tau and its variants similarly change the microtubule lattice structure by increasing both the protofilament number and lattice defects. Overall, our results uncover novel phospho-dependent mechanisms governing tau's ability to trigger microtubule organization and reveal that disease-related modifications of tau promote specific microtubule organizations which may have a deleterious impact during neurodegeneration. © 2017 by The American Society for Cell Biology.

  8. Experimental Study on the Flow Characteristics in a Bare Rod Bundle Array

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Seok Kyu; Kim, Bok Deuk; Moon, Sang Ki [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    2006-07-01

    Structure of a rod bundle array in thermal-hydraulic environment is widely used and very important issues in the industrial field. Especially, in nuclear power plant, this structure is essential in the reactor and steam generator. Because of such an industrial importance, there have been many experimental studies on the flow characteristics in a rod bundle array. During two decades from 1970, fundamental studies on the flow mixing in a bare rod bundle have been frequently performed. Rowe et al. measured the axial and some lateral velocities and their turbulence intensities by using 2-D LDV system. They found the existence of the longitudinal macro-scale and the dominant frequency of turbulence in a sub-channel mixing. Neti et al. also performed the LDV measurements for a 3x3 rod array and presented the lateral fluctuations were about 1% magnitudes of the axial flow. Renksizbulut et al. measured the shear stress of the rod surface and estimates the secondary flow in a sub-channel and Vonka also confirmed the secondary flow in his experimental work. In spite of many experimental studies on the flow mixing in a sub-channel geometry on a bare rod bundle, there were no full measurement information in a subchannel. This study attempted to the detailed full measurement of the lateral velocities as well as the axial velocities in a sub-channel geometry on a 5x5 rod bundle.

  9. Electrocardiogram: his bundle potentials can be recorded noninvasively beat by beat on surface electrocardiogram.

    Science.gov (United States)

    Wang, Gaopin; Liu, Renguang; Chang, Qinghua; Xu, Zhaolong; Zhang, Yingjie; Pan, Dianzhu

    2017-03-15

    The micro waveform of His bundle potential can't be recorded beat-to-beat on surface electrocardiogram yet. We have found that the micro-wavelets before QRS complex may be related to atrioventricular conduction system potentials. This study is to explore the possibility of His bundle potential can be noninvasively recorded on surface electrocardiogram. We randomized 65 patients undergoing radiofrequency catheter ablation of paroxysmal superventricular tachycardia (exclude overt Wolff-Parkinson-White syndrome) to receive "conventional electrocardiogram" and "new electrocardiogram" before the procedure. His bundle electrogram was collected during the procedure. Comparative analysis of PA s (PA interval recorded on surface electrocardiogram), AH s (AH interval recorded on surface electrocardiogram) and HV s (HV interval recorded on surface electrocardiogram) interval recorded on surface "new electrocardiogram" and PA, AH, HV interval recorded on His bundle electrogram was investigated. There was no difference (P > 0.05) between groups in HV s interval (49.63 ± 6.19 ms) and HV interval (49.35 ± 6.49 ms). Results of correlational analysis found that HV S interval was significantly positively associated with HV interval (r = 0.929; P electrocardiogram. Noninvasive His bundle potential tracing might represent a new method for locating the site of atrioventricular block and identifying the origin of a wide QRS complex.

  10. On Vascular Bundle Modifications in Nodes and Internodes of Selected Grass Species

    Directory of Open Access Journals (Sweden)

    Kraehmer H.

    2017-09-01

    Full Text Available Grass nodes play an essential role as interfaces between leaf and stem. The description of the bundle course in nodes considerably contributes to understanding of the transport of assimilates, minerals, and xenobiotics in grasses. Nodes and internodes of 38 species of the subfamilies Arundinoideae, Bambusoideae, Panicoideae, and Pooideae were analyzed histologically. Free-hand sections, various staining techniques, macro- and microphotography were used to reveal a few principles underlying their anatomy. In all grass species, specific nodal zones were found in which many vascular bundles undergo characteristic transformations. This transformation starts with the augmentation of xylem in lower nodal areas and continues with the formation of specific amphivasal structures providing connections with the leaf attached to the node. The anatomy of these strands, herein called vasotubuli, has not much in common with vascular bundles in internodes any more. Transverse nodal plexus strands provide many connections between bundles and vasotubuli. The nodal plexus is also an interface of sclerenchyma bundles. The nodes of most grass species are constructed very similarly with a few exceptions: the nodes of Phragmites australis (Cav. Steud. for example have something in common with bamboo: they develop spindle-like glomeruli.

  11. FUNCTION OF MALATDEHYDROGENASE COMPLEX OF MAIZE MESOPHYLL AND BUNDLE SHEATH CELLS UNDER SALT STRESS CONDITION

    Directory of Open Access Journals (Sweden)

    Еprintsev А.Т.

    2006-12-01

    Full Text Available Salt-induced changes in malatdehydrogenase system activity make the essential contribution to cell adaptation to stress condition. The enzyme systems of C4-plants are most interesting due to their ability for adaptation to environment conditions. The role of separate components of malatdehydrogenase complex of mesophyll and bundle sheath cells of corn in formation of adaptive reaction in stressful conditions is investigated in presented work.The activation of all enzymes of malatdehydrogenase system and the subsequent decrease in their activity was observed in mesophyll durring the first stage of adaptation to salt influence. In bundle sheath cells such parameters are differed from control less essentially. Fast accumulation of piruvate in cells and malate in both investigated tissues was induced. The further salinity led to falling of concentration this intermediate. The concentration of piruvate was below control level, and it was raised by the end of an exposition.The results show that sodium chloride causes induction of Krebs-cycle in mesophyll and bundle sheath cells of corn and intensification of Hatch-Slack cycle. The described differences in function malatdehydrogenase systems of mesophyll and bundle sheath cells of leaves of corn under salinity mainly consist of the activity of enzymes of a studied complex in bundle sheath cells is subject to the minimal changes in comparison with mesophyll. Role of this enzymesystem in mechanisms of adaptive reaction of various tissues of corn to salt stress is discussed.

  12. Thread-based microfluidics: Flow patterns in homogeneous and heterogeneous microfiber bundles.

    Science.gov (United States)

    Berthier, J; Brakke, K A; Gosselin, D; Berthier, E; Navarro, F

    2017-10-01

    Thread-based microfluidics has recently seen considerable developments in the domain of portable diagnostic systems, smart bandages and tissue engineering. Similarly to paper-based microfluidics, thread-based microfluidics uses the wicking of fibers to move fluids. It has the advantage of confining and guiding the fluid along the yarns in a one, two or three dimensional space. A global approach to the motion of fluids in yarns and fiber bundles has already been reported in the literature based on the Lucas-Washburn-Rideal law. However no detailed investigation of the flow pattern inside the bundle has been conducted, depending on the internal structure of the bundle. Especially when the bundle possesses heterogeneous wetting properties, such as two different wetting regions interior and exterior, different flow patterns may exist. In this work, we perform a theoretical and numerical analysis of the different flow regimes for homogenous and heterogeneous fiber bundles. It is demonstrated that a limited number of fibers is sufficient for thread-based capillary flows, and that a caging of the flow can be achieved by realizing a lyophobic envelope. Copyright © 2017 IPEM. Published by Elsevier Ltd. All rights reserved.

  13. Page 1 92 Madhay V Nori In any case oſq., is a principal H-bundle ...

    Indian Academy of Sciences (India)

    In any case oſq., is a principal H-bundle on U, and by case 2, 2/Gise is the inverse image of U in a principal H-bundle Z – W. The pair (Z, Ql Go.) have the same properties as (X, U) and Q – Q|G|... is a principal Gºss-bundle; by case 1, Q is the inverse image of Q|G, in a principal Gos-bundle W - 2. Thus. Q is the inverse image ...

  14. Tuning the entropic spring to dictate order and functionality in polymer conjugated peptide biomaterials

    Science.gov (United States)

    Keten, Sinan

    Hybrid peptide-polymer conjugates have the potential to combine the advantages of natural proteins and synthetic polymers, resulting in biomaterials with improved stability, controlled assembly, and tailored functionalities. However, the effect of polymer conjugation on peptide structural organization and functionality, along with the behavior of polymers at the interface with biomolecules remain to be fully understood. This talk will summarize our recent efforts towards establishing a modeling framework to design entropic forces in helix-polymer conjugates and polymer-conjugated peptide nanotubes to achieve hierarchical self-assembling systems with predictable order. The first part of the talk will discuss how self-assembly principles found in biology, combined with polymer physics concepts can be used to create artificial membranes that mimic certain features of ion channels. Thermodynamics and kinetics aspects of self-assembly and how it governs the growth and stacking sequences of peptide nanotubes will be discussed, along with its implications for nanoscale transport. The second part of the talk will review advances related to modeling polymer conjugated coiled coils at relevant length and time scales. Atomistic simulations combined with sampling techniques will be presented to discuss the energy landscapes governing coiled-coil stability, revealing cascades of events governing disassembly. This will be followed by a discussion of mechanisms through which polymers can stabilize small proteins, such as shielding of solvents, and how specific peptide sequences can reciprocate by altering polymer conformations. Correlations between mechanical and thermal stability of peptides will be discussed. Finally, coarse-grained simulations will provide insight into how the location of polymer attachment changes entropic forces and higher-level organization in helix bundle assemblies. Our findings set the stage for a materials-by-design capability towards dictating complex

  15. Solid-phase peptide synthesis

    DEFF Research Database (Denmark)

    Jensen, Knud Jørgen

    2013-01-01

    This chapter provides an introduction to and overview of peptide chemistry with a focus on solid-phase peptide synthesis. The background, the most common reagents, and some mechanisms are presented. This chapter also points to the different chapters and puts them into perspective.......This chapter provides an introduction to and overview of peptide chemistry with a focus on solid-phase peptide synthesis. The background, the most common reagents, and some mechanisms are presented. This chapter also points to the different chapters and puts them into perspective....

  16. Biodiscovery of aluminum binding peptides

    Science.gov (United States)

    Adams, Bryn L.; Sarkes, Deborah A.; Finch, Amethist S.; Hurley, Margaret M.; Stratis-Cullum, Dimitra

    2013-05-01

    Cell surface peptide display systems are large and diverse libraries of peptides (7-15 amino acids) which are presented by a display scaffold hosted by a phage (virus), bacteria, or yeast cell. This allows the selfsustaining peptide libraries to be rapidly screened for high affinity binders to a given target of interest, and those binders quickly identified. Peptide display systems have traditionally been utilized in conjunction with organic-based targets, such as protein toxins or carbon nanotubes. However, this technology has been expanded for use with inorganic targets, such as metals, for biofabrication, hybrid material assembly and corrosion prevention. While most current peptide display systems employ viruses to host the display scaffold, we have recently shown that a bacterial host, Escherichia coli, displaying peptides in the ubiquitous, membrane protein scaffold eCPX can also provide specific peptide binders to an organic target. We have, for the first time, extended the use of this bacterial peptide display system for the biodiscovery of aluminum binding 15mer peptides. We will present the process of biopanning with macroscopic inorganic targets, binder enrichment, and binder isolation and discovery.

  17. Antitumor Peptides from Marine Organisms

    Directory of Open Access Journals (Sweden)

    Mi Sun

    2011-10-01

    Full Text Available The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of new antitumor agents in the field of the development of marine bioactive substances. In this review, the progress on studies of antitumor peptides from marine sources is provided. The biological properties and mechanisms of action of different marine peptides are described; information about their molecular diversity is also presented. Novel peptides that induce apoptosis signal pathway, affect the tubulin-microtubule equilibrium and inhibit angiogenesis are presented in association with their pharmacological properties. It is intended to provide useful information for further research in the fields of marine antitumor peptides.

  18. Improving Peptide Applications Using Nanotechnology.

    Science.gov (United States)

    Narayanaswamy, Radhika; Wang, Tao; Torchilin, Vladimir P

    2016-01-01

    Peptides are being successfully used in various fields including therapy and drug delivery. With advancement in nanotechnology and targeted delivery carrier systems, suitable modification of peptides has enabled achievement of many desirable goals over-riding some of the major disadvantages associated with the delivery of peptides in vivo. Conjugation or physical encapsulation of peptides to various nanocarriers, such as liposomes, micelles and solid-lipid nanoparticles, has improved their in vivo performance multi-fold. The amenability of peptides to modification in chemistry and functionalization with suitable nanocarriers are very relevant aspects in their use and have led to the use of 'smart' nanoparticles with suitable linker chemistries that favor peptide targeting or release at the desired sites, minimizing off-target effects. This review focuses on how nanotechnology has been used to improve the number of peptide applications. The paper also focuses on the chemistry behind peptide conjugation to nanocarriers, the commonly employed linker chemistries and the several improvements that have already been achieved in the areas of peptide use with the help of nanotechnology.

  19. Peptides and Food Intake

    Science.gov (United States)

    Sobrino Crespo, Carmen; Perianes Cachero, Aránzazu; Puebla Jiménez, Lilian; Barrios, Vicente; Arilla Ferreiro, Eduardo

    2014-01-01

    The mechanisms for controlling food intake involve mainly an interplay between gut, brain, and adipose tissue (AT), among the major organs. Parasympathetic, sympathetic, and other systems are required for communication between the brain satiety center, gut, and AT. These neuronal circuits include a variety of peptides and hormones, being ghrelin the only orexigenic molecule known, whereas the plethora of other factors are inhibitors of appetite, suggesting its physiological relevance in the regulation of food intake and energy homeostasis. Nutrients generated by food digestion have been proposed to activate G-protein-coupled receptors on the luminal side of enteroendocrine cells, e.g., the L-cells. This stimulates the release of gut hormones into the circulation such as glucagon-like peptide-1 (GLP-1), oxyntomodulin, pancreatic polypeptides, peptide tyrosine tyrosine, and cholecystokinin, which inhibit appetite. Ghrelin is a peptide secreted from the stomach and, in contrast to other gut hormones, plasma levels decrease after a meal and potently stimulate food intake. Other circulating factors such as insulin and leptin relay information regarding long-term energy stores. Both hormones circulate at proportional levels to body fat content, enter the CNS proportionally to their plasma levels, and reduce food intake. Circulating hormones can influence the activity of the arcuate nucleus (ARC) neurons of the hypothalamus, after passing across the median eminence. Circulating factors such as gut hormones may also influence the nucleus of the tractus solitarius (NTS) through the adjacent circumventricular organ. On the other hand, gastrointestinal vagal afferents converge in the NTS of the brainstem. Neural projections from the NTS, in turn, carry signals to the hypothalamus. The ARC acts as an integrative center, with two major subpopulations of neurons influencing appetite, one of them coexpressing neuropeptide Y and agouti-related protein (AgRP) that increases food

  20. Anticancer peptides from bacteria

    Directory of Open Access Journals (Sweden)

    Tomasz M. Karpiński

    2013-08-01

    Full Text Available Cancer is a leading cause of death in the world. The rapid development of medicine and pharmacology allows to create new and effective anticancer drugs. Among modern anticancer drugs are bacterial proteins. Until now has been shown anticancer activity among others azurin and exotoxin A from Pseudomonas aeruginosa, Pep27anal2 from Streptococcus pneumoniae, diphtheria toxin from Corynebacterium diphtheriae, and recently discovered Entap from Enterococcus sp. The study presents the current data regarding the properties, action and anticancer activity of listed peptides.

  1. Peptide Vaccines for Cancer

    Directory of Open Access Journals (Sweden)

    Kono K

    2013-10-01

    Full Text Available Background: In general, the preferable characteristic of the target molecules for development of cancer vaccines are high immunogenicity, very common expression in cancer cells, specific expression in cancer cells and essential molecules for cell survival (to avoid loss of expression. We previously reported that three novel HLA-A24-restricted immunodominant peptides, which were derived from three different oncoantigens, TTK, LY6K, and IMP-3,were promising targets for cancer vaccination for esophageal squamous cell carcinoma (ESCCpatients. Then, we had performed a phase I clinical trial using three HLA-A24-binding peptides and the results had been shown to be promising for ESCC. Therefore, we further performed a multicenter, non-randomized phase II clinical trial. Patients and Methods: Sixty ESCC patients were enrolled to evaluate OS, PFS, immunological response employing ELISPOT and pentamer assays. Each of the three peptides was administered with IFA weekly. All patients received the vaccination without knowing an HLA-A type, and the HLA types were key-opened at the analysis point. Hence, the endpoints were set to evaluate differences between HLA-A*2402-positive (24(+ and -negative (24(- groups. Results: The OS in the 24 (+ group (n=35 tended to be better than that in the 24(- group (n=25 (MST 4.6 vs. 2.6 month, respectively, p = 0.121, although the difference was not statistically significant. However, the PFS in the 24(+ group was significantly better than that in the 24(- group (p = 0.032. In the 24(+ group, ELISPOT assay indicated that the LY6K-, TTK-, and IMP3-specific CTL responses were observed after the vaccination in 63%, 45%, and 60% of the 24(+ group, respectively. The patients having LY6K-, TTK-, and IMP3-specific CTL responses revealed the better OS than those not having CTL induction, respectively. The patients showing the CTL induction for multiple peptides have better clinical responses. Conclusion: The immune response induced

  2. Electrospun nanofibre bundles and yarns for tissue engineering applications: A review.

    Science.gov (United States)

    O'Connor, Richard A; McGuinness, Garrett B

    2016-11-01

    Nanofibre membranes produced through the electrospinning process have been studied extensively over the past decade for a number of high demand applications including use as tissue engineered scaffolds. Despite possessing desirable properties including high surface area to volume ratios and enhanced mechanical properties, they ultimately suffer from a lack of cellular infiltration. Variations on the process include the production of highly aligned filaments of electrospun fibres referred to as bundles and yarns. Nanofibre bundle and yarn-based scaffolds have been shown to demonstrate superior cell infiltration rates compared to traditional electrospun nonwovens while also offering the capability to be incorporated into a wider array of post-processing technologies. In this review, fibre collection techniques currently employed within the literature for the fabrication of electrospun bundles and yarns along with their applications in the field of tissue engineering will be discussed.

  3. Pool boiling of distilled water over tube bundle with variable heat flux

    Science.gov (United States)

    Swain, Abhilas; Mohanty, Rajiva Lochan; Das, Mihir Kumar

    2017-08-01

    The experimental investigation of saturated pool boiling heat transfer of distilled water over plain tube bundle, under uniform and varying heat flux condition along the height are presented in this article. Experiments are carried out under various heat flux configurations applied to rows of tube bundles and pitch distance to diameter ratios of 1.25, 1.6 and 1.95. The wall superheats and pool boiling heat transfer coefficients over individual rows are determined. The pool boiling heat transfer coefficients for variable heat flux and uniform heat flux conditions are compared. The results indicate that the bundle effect is found to exist for uniform as well as variable heat flux under all operating conditions in the present investigation. The variable heat flux resulted in range of wall superheat being highest for decreasing heat flux from bottom to top and lowest for increasing heat flux from bottom to top.

  4. Classification of "Quaternionic" Bloch-Bundles. Topological Quantum Systems of Type AII

    Science.gov (United States)

    De Nittis, Giuseppe; Gomi, Kiyonori

    2015-10-01

    We provide a classification of type AII topological quantum systems in dimension d = 1, 2, 3, 4. Our analysis is based on the construction of a topological invariant, the FKMM-invariant, which completely classifies "Quaternionic" vector bundles ( a.k.a. "symplectic" vector bundles) in dimension . This invariant takes value in a proper equivariant cohomology theory and, in the case of examples of physical interest, it reproduces the familiar Fu-Kane-Mele index. In the case d = 4 the classification requires a combined use of the FKMM-invariant and the second Chern class. Among the other things, we prove that the FKMM-invariant is a bona fide characteristic class for the category of "Quaternionic" vector bundles in the sense that it can be realized as the pullback of a universal topological invariant.

  5. Nursing intervention bundle for enteral nutrition in intensive care: a collective construction

    Directory of Open Access Journals (Sweden)

    Aline Daiane Colaço

    2014-10-01

    Full Text Available Objective The collective construction of a nursing intervention bundle for patients in critical care in the hospital receiving enteral nutrition therapy, supported by evidence-based practice. Method A qualitative convergent-care study with 24 nursing professionals in an intensive care unit of a public hospital in Santa Catarina. Data collection was performed from May to August 2013, with semi-structured interviews and discussion groups. Results Four interventions emerged that constituted the bundle: bedside pH monitoring to confirm the position of the tube; stabilization of the tube; enteric position of the tube; and maintaining the head of the bed elevated at 30° to 45°.
 Conclusion The interventions chosen neither required additional professional workload nor extra charges to the institution, which are identified as improving the adoption of the bundle by nursing professionals at the ICU.

  6. Nursing intervention bundle for enteral nutrition in intensive care: a collective construction

    Directory of Open Access Journals (Sweden)

    Aline Daiane Colaço

    Full Text Available Objective The collective construction of a nursing intervention bundle for patients in critical care in the hospital receiving enteral nutrition therapy, supported by evidence-based practice. Method A qualitative convergent-care study with 24 nursing professionals in an intensive care unit of a public hospital in Santa Catarina. Data collection was performed from May to August 2013, with semi-structured interviews and discussion groups. Results Four interventions emerged that constituted the bundle: bedside pH monitoring to confirm the position of the tube; stabilization of the tube; enteric position of the tube; and maintaining the head of the bed elevated at 30° to 45°.
 Conclusion The interventions chosen neither required additional professional workload nor extra charges to the institution, which are identified as improving the adoption of the bundle by nursing professionals at the ICU.

  7. Effective action of heterotic compactification on K3 with non-trivial gauge bundles

    Energy Technology Data Exchange (ETDEWEB)

    Schasny, Martin

    2012-10-15

    In this thesis we study the heterotic string compactified on K3 with non-trivial gauge bundles. We focus on two backgrounds, the well-known standard embedding and abelian line bundles. Using a Kaluza-Klein reduction, the six-dimensional effective action is computed up to terms of order {alpha}'{sup 2} with special attention on the hypermultiplet sector. We compute the moduli dependent couplings of the matter fields and analyze the geometry of the hyperscalar sigma model. Moreover, we prove the consistency with six-dimensional supergravity and derive the appropriate D-term scalar potential. For the line bundle backgrounds we show that the gauge flux stabilizes some geometrical moduli and renders some abelian vector multiplets massive.

  8. Bundle adjustment with additional constraints applied to imagery of the Dunhuang wall paintings

    Science.gov (United States)

    Zhang, Yongjun; Hu, Kun; Huang, Rongyong

    2012-08-01

    In the digital conservation of the Dunhuang wall painting, bundle adjustment is a critical step in precise orthoimage generation. The error propagation of the adjustment model is accelerated because the near-planar photographic object intensifies correlation of the exterior orientation parameters and the less than 60% forward overlap of adjacent images weakens the geometric connection of the network. According to the photographic structure adopted in this paper, strong correlation of the exterior orientation parameters can be verified theoretically. In practice, the additional constraints of near-planarity and exterior orientation parameters are combined with bundle adjustment to control the error propagation. The positive effects of the additional constraints are verified by experiments, which show that the introduction of weighted observation equations into bundle adjustment contributes a great deal to the theoretical and actual accuracies of the unknowns as well as the stability of the adjustment model.

  9. Field Emission Characteristics of the Structure of Vertically Aligned Carbon Nanotube Bundles.

    Science.gov (United States)

    Lin, Pao-Hung; Sie, Cong-Lin; Chen, Ching-An; Chang, Hsuan-Chen; Shih, Yi-Ting; Chang, Hsin-Yueh; Su, Wei-Jhih; Lee, Kuei-Yi

    2015-12-01

    In this study, we performed thermal chemical vapor deposition for growing vertically aligned carbon nanotube (VACNT) bundles for a field emitter and applied photolithography for defining the arrangement pattern to simultaneously compare square and hexagonal arrangements by using two ratios of the interbundle distance to the bundle height (R) of field emitters. The hexagon arrangement with R = 2 had the lowest turn-on electric field (E to) and highest enhancement factor, whereas the square arrangement with R = 3 had the most stable field emission (FE) characteristic. The number density can reveal the correlation to the lowest E to and highest enhancement factor more effectively than can the R or L. The fluorescent images of the synthesized VACNT bundles manifested the uniformity of FE currents. The results of our study indicate the feasibility of applying the VACNT field emitter arrangement to achieve optimal FE performance.

  10. Size scaling of failure strength with fat-tailed disorder in a fiber bundle model

    Science.gov (United States)

    Kádár, Viktória; Danku, Zsuzsa; Kun, Ferenc

    2017-09-01

    We investigate the size scaling of the macroscopic fracture strength of heterogeneous materials when microscopic disorder is controlled by fat-tailed distributions. We consider a fiber bundle model where the strength of single fibers is described by a power law distribution over a finite range. Tuning the amount of disorder by varying the power law exponent and the upper cutoff of fibers' strength, in the limit of equal load sharing an astonishing size effect is revealed: For small system sizes the bundle strength increases with the number of fibers, and the usual decreasing size effect of heterogeneous materials is restored only beyond a characteristic size. We show analytically that the extreme order statistics of fibers' strength is responsible for this peculiar behavior. Analyzing the results of computer simulations we deduce a scaling form which describes the dependence of the macroscopic strength of fiber bundles on the parameters of microscopic disorder over the entire range of system sizes.

  11. The many faces of Maxwell, Dirac and Einstein equations a Clifford bundle approach

    CERN Document Server

    Rodrigues, Jr, Waldyr A

    2016-01-01

    This book is an exposition of the algebra and calculus of differential forms, of the Clifford and Spin-Clifford bundle formalisms, and of vistas to a formulation of important concepts of differential geometry indispensable for an in-depth understanding of space-time physics. The formalism discloses the hidden geometrical nature of spinor fields. Maxwell, Dirac and Einstein fields are shown to have representatives by objects of the same mathematical nature, namely sections of an appropriate Clifford bundle. This approach reveals unity in diversity and suggests relationships that are hidden in the standard formalisms and opens new paths for research. This thoroughly revised second edition also adds three new chapters: on the Clifford bundle approach to the Riemannian or semi-Riemannian differential geometry of branes; on Komar currents in the context of the General Relativity theory; and an analysis of the similarities and main differences between Dirac, Majorana and ELKO spinor fields. The exercises with solut...

  12. [Nursing intervention bundle for enteral nutrition in intensive care: a collective construction].

    Science.gov (United States)

    Colaço, Aline Daiane; Nascimento, Eliane Regina Pereira do

    2014-10-01

    The collective construction of a nursing intervention bundle for patients in critical care in the hospital receiving enteral nutrition therapy, supported by evidence-based practice. A qualitative convergent-care study with 24 nursing professionals in an intensive care unit of a public hospital in Santa Catarina. Data collection was performed from May to August 2013, with semi-structured interviews and discussion groups. Four interventions emerged that constituted the bundle: bedside pH monitoring to confirm the position of the tube; stabilization of the tube; enteric position of the tube; and maintaining the head of the bed elevated at 30° to 45°.
 The interventions chosen neither required additional professional workload nor extra charges to the institution, which are identified as improving the adoption of the bundle by nursing professionals at the ICU.

  13. Modeling of Thermal Conductivity of CVI-Densified Composites at Fiber and Bundle Level

    Science.gov (United States)

    Guan, Kang; Wu, Jianqing; Cheng, Laifei

    2016-01-01

    The evolution of the thermal conductivities of the unidirectional, 2D woven and 3D braided composites during the CVI (chemical vapor infiltration) process have been numerically studied by the finite element method. The results show that the dual-scale pores play an important role in the thermal conduction of the CVI-densified composites. According to our results, two thermal conductivity models applicable for CVI process have been developed. The sensitivity analysis demonstrates the parameter with the most influence on the CVI-densified composites’ thermal conductivity is matrix cracking’s density, followed by volume fraction of the bundle and thermal conductance of the matrix cracks, finally by micro-porosity inside the bundles and macro-porosity between the bundles. The obtained results are well consistent with the reported data, thus our models could be useful for designing the processing and performance of the CVI-densified composites. PMID:28774130

  14. The Effects of Resource Bundling on Third-party Logistics Providers’ Performance

    Directory of Open Access Journals (Sweden)

    Noorliza Karia

    2015-03-01

    resource bundling (excluding advanced technology is required to achieve cost leadership. The effects of other resources on performance are mediated mainly by the demand management interface capability and knowledge resources. This is a novel attempt to justify the interaction and mediation effects of resources and capabilities on performance. The research highlights the needs for 3PL managers to focus on developing and bundling their demand management interface capability and knowledge resources in order to achieve cost leadership, and further combine advanced technology into such bundling of resources and capabilities to achieve innovation in customer service. It advances the application of resource-based view (RBV theory in logistics research by identifying resources that play supporting roles and examining the capabilities for enhancing 3PLs’ competitive performance.

  15. Design of automatic labeling system on the end surfaces of bundles of round steels

    Directory of Open Access Journals (Sweden)

    Fuxiang ZHANG

    2016-12-01

    Full Text Available To achieve automatic labeling on the end surfaces of bundles of round steels for the steel plants, on the basis of the analysis of round steel production process, a set of automatic system for labeling on the round steel end surfaces of bundles is designed. The system includes the robot visual location unit, the label supply unit, the pressure supply unit, the automatic labeling unit, the laser ranging unit, and the host computer communication control unit, etc.. In the system, the robot visual location unit provides the round steel center location, and the automatic labeling unit implements automatic labeling on the round steel. The system is tested under lab condition, which shows the system can effectively solve the artificial labeling problems such as fault paste and leakage paste of workers, and realize efficient and stable automatic labeling. The system can be used in sleel plants for automatic labeling on the end surfaces of bundles of round steels.

  16. AKTIVITAS BANCASSURANCE DALAM DUNIA PERBANKAN: ADAKAH PRAKTIK BUNDLING YANG MELANGGAR HUKUM PERSAINGAN USAHA?

    Directory of Open Access Journals (Sweden)

    Indirani Wauran-Wicaksono

    2015-04-01

    Insurance companies develop marketing strategies to promote their product called bancassurance. According to the SE BI No. 12/35/DPNP dated December 23, 2010, bancassurance had some category. Furthermore, it is known that there is a kind of bancassurance that included in the category of pure product bundling or often referred as tying. This bundling categories fall under exclusive dealing provision that basically prohibited by the Competition Act, with rule of reason approach. By considering the current condition of the insurance company’s market share, it could be said that pure product bundling or tying in bancassurance is not infringe competition law however have a very small potential to creates monopolistic practices and unfair business competition, therefore violating Competition Law.

  17. Single Institution Early Experience with the Bundled Payments for Care Improvement Initiative.

    Science.gov (United States)

    Iorio, Richard; Bosco, Joseph; Slover, James; Sayeed, Yousuf; Zuckerman, Joseph D

    2017-01-04

    The Centers for Medicare & Medicaid Services (CMS) implemented the Bundled Payments for Care Improvement (BPCI) initiative in 2011. Through BPCI, organizations enlisted into payment agreements that include both performance and financial accountability for episodes of care. To succeed, BPCI requires quality maintenance and care delivery at lower costs. This necessitates physicians and hospitals to merge interests. Orthopaedic surgeons must assume leadership roles in cost containment, surgical safety, and quality assurance to deliver cost-effective care. Because most orthopaedic surgeons practice independently and are not employed by hospitals, models of physician-hospital alignment (e.g., physician-hospital organizations) or contracted gainsharing arrangements between practices and hospitals may be necessary for successful bundled pricing. Under BPCI, hospitals, surgeons, or third parties share rewards but assume risks for the bundle.For patients, cost savings must be associated with maintenance or improvement in quality metrics. However, the definition of quality can vary, as can the rewards for processes and outcomes. Risk stratification for potential complications should be considered in bundled pricing agreements to prevent the exclusion of patients with substantial comorbidities and higher care costs (e.g., hip fractures treated with prostheses). Bundled pricing depends on economies of scale for success; smaller institutions must be cautious, as 1 costly patient could substantially impact the finances of its entire program. CMS recommends a minimum of 100 to 200 cases yearly. We also suggest that participants utilize technologies to maximize efficiency and provide the best possible environment for implementation of bundled payments. Substantial investment in infrastructure is required to develop programs to improve coordination of care, manage quality data, and distribute payments. Smaller institutions may have difficulty devoting resources to these

  18. RecA bundles mediate homology pairing between distant sisters during DNA break repair

    Science.gov (United States)

    Lesterlin, Christian; Ball, Graeme; Schermelleh, Lothar; Sherratt, David J.

    2014-02-01

    DNA double-strand break (DSB) repair by homologous recombination has evolved to maintain genetic integrity in all organisms. Although many reactions that occur during homologous recombination are known, it is unclear where, when and how they occur in cells. Here, by using conventional and super-resolution microscopy, we describe the progression of DSB repair in live Escherichia coli. Specifically, we investigate whether homologous recombination can occur efficiently between distant sister loci that have segregated to opposite halves of an E. coli cell. We show that a site-specific DSB in one sister can be repaired efficiently using distant sister homology. After RecBCD processing of the DSB, RecA is recruited to the cut locus, where it nucleates into a bundle that contains many more RecA molecules than can associate with the two single-stranded DNA regions that form at the DSB. Mature bundles extend along the long axis of the cell, in the space between the bulk nucleoid and the inner membrane. Bundle formation is followed by pairing, in which the two ends of the cut locus relocate at the periphery of the nucleoid and together move rapidly towards the homology of the uncut sister. After sister locus pairing, RecA bundles disassemble and proteins that act late in homologous recombination are recruited to give viable recombinants 1-2-generation-time equivalents after formation of the initial DSB. Mutated RecA proteins that do not form bundles are defective in sister pairing and in DSB-induced repair. This work reveals an unanticipated role of RecA bundles in channelling the movement of the DNA DSB ends, thereby facilitating the long-range homology search that occurs before the strand invasion and transfer reactions.

  19. Temperature Distributions in LMR Fuel Pin Bundles as Modeled by COBRA-IV-I

    Science.gov (United States)

    Wright, Steven A.; Stout, Sherry

    2005-02-01

    Most pin type reactor designs for space power or terrestrial applications group the fuel pins into a number of relatively large fuel pin bundles or subassemblies. Fuel bundles for terrestrial liquid metal fast breeders reactors typically use 217 - 271 pins per sub-assembly, while some SP100 designs use up to 331 pins in a central subassembly that was surrounded by partial assemblies. Because thermal creep is exponentially related to temperature, small changes in fuel pin cladding temperature can make large differences in the lifetime in a high temperature liquid metal reactor (LMR). This paper uses the COBRA-IV-I computer code to determine the temperature distribution within LMR fuel bundles. COBRA-IV-I uses the sub-channel analysis approach to determine the enthalpy (or temperature) and flow distribution in rod bundles for both steady-state and transient conditions. The COBRA code runs in only a few seconds and has been benchmarked and tested extensively over a wide range of flow conditions. In this report the flow and temperature distributions for two types of lithium cooled space reactor core designs were calculated. One design uses a very tight fuel pin packing that has a pitch to diameter ratio of 1.05 (small wire wrap with a diameter of 392 μm) as proposed in SP100. The other design uses a larger pitch to diameter ratio of 1.09 with a larger more conventional sized wire wrap diameter of 1 mm. The results of the COBRA pin bundle calculations show that the larger pitch-to-diameter fuel bundle designs are more tolerant to local flow blockages, and in addition they are less sensitive to mal-flow distributions that occur near the edges of the subassembly.

  20. Use of the Delay-Tolerant Networking Bundle Protocol from Space

    Science.gov (United States)

    Wood, Lloyd; Ivancic, William D.; Eddy, Wesley M.; Stewart, Dave; Northam, James; Jackson, Chris; daSilvaCuriel, Alex

    2009-01-01

    The Disaster Monitoring Constellation (DMC), constructed by Survey Satellite Technology Ltd (SSTL), is a multisatellite Earth-imaging low-Earth-orbit sensor network where captured image swaths are stored onboard each satellite and later downloaded from the satellite payloads to a ground station. Store-and-forward of images with capture and later download gives each satellite the characteristics of a node in a Delay/Disruption Tolerant Network (DTN). Originally developed for the Interplanetary Internet, DTNs are now under investigation in an Internet Research Task Force (IRTF) DTN research group (RG), which has developed a bundle architecture and protocol. The DMC is currently unique in its adoption of the Internet Protocol (IP) for its imaging payloads and for satellite command and control, based around reuse of commercial networking and link protocols. These satellites use of IP has enabled earlier experiments with the Cisco router in Low Earth Orbit (CLEO) onboard the constellation's UK-DMC satellite. Earth images are downloaded from the satellites using a custom IPbased high-speed transfer protocol developed by SSTL, Saratoga, which tolerates unusual link environments. Saratoga has been documented in the Internet Engineering Task Force (IETF) for wider adoption. We experiment with use of DTNRG bundle concepts onboard the UKDMC satellite, by examining how Saratoga can be used as a DTN convergence layer to carry the DTNRG Bundle Protocol, so that sensor images can be delivered to ground stations and beyond as bundles. This is the first successful use of the DTNRG Bundle Protocol in a space environment. We use our practical experience to examine the strengths and weaknesses of the Bundle Protocol for DTN use, paying attention to fragmentation, custody transfer, and reliability issues.

  1. Cooperative retraction of bundled type IV pili enables nanonewton force generation.

    Directory of Open Access Journals (Sweden)

    Nicolas Biais

    2008-04-01

    Full Text Available The causative agent of gonorrhea, Neisseria gonorrhoeae, bears retractable filamentous appendages called type IV pili (Tfp. Tfp are used by many pathogenic and nonpathogenic bacteria to carry out a number of vital functions, including DNA uptake, twitching motility (crawling over surfaces, and attachment to host cells. In N. gonorrhoeae, Tfp binding to epithelial cells and the mechanical forces associated with this binding stimulate signaling cascades and gene expression that enhance infection. Retraction of a single Tfp filament generates forces of 50-100 piconewtons, but nothing is known, thus far, on the retraction force ability of multiple Tfp filaments, even though each bacterium expresses multiple Tfp and multiple bacteria interact during infection. We designed a micropillar assay system to measure Tfp retraction forces. This system consists of an array of force sensors made of elastic pillars that allow quantification of retraction forces from adherent N. gonorrhoeae bacteria. Electron microscopy and fluorescence microscopy were used in combination with this novel assay to assess the structures of Tfp. We show that Tfp can form bundles, which contain up to 8-10 Tfp filaments, that act as coordinated retractable units with forces up to 10 times greater than single filament retraction forces. Furthermore, single filament retraction forces are transient, whereas bundled filaments produce retraction forces that can be sustained. Alterations of noncovalent protein-protein interactions between Tfp can inhibit both bundle formation and high-amplitude retraction forces. Retraction forces build over time through the recruitment and bundling of multiple Tfp that pull cooperatively to generate forces in the nanonewton range. We propose that Tfp retraction can be synchronized through bundling, that Tfp bundle retraction can generate forces in the nanonewton range in vivo, and that such high forces could affect infection.

  2. Motor-mediated bidirectional transport along an antipolar microtubule bundle: A mathematical model

    Science.gov (United States)

    Lin, Congping; Ashwin, Peter; Steinberg, Gero

    2013-05-01

    Long-distance bidirectional transport of organelles depends on the coordinated motion of various motor proteins on the cytoskeleton. Recent quantitative live cell imaging in the elongated hyphal cells of Ustilago maydis has demonstrated that long-range motility of motors and their endosomal cargo occurs on unipolar microtubules (MTs) near the extremities of the cell. These MTs are bundled into antipolar bundles within the central part of the cell. Dynein and kinesin-3 motors coordinate their activity to move early endosomes (EEs) in a bidirectional fashion where dynein drives motility towards MT minus ends and kinesin towards MT plus ends. Although this means that one can easily assign the drivers of bidirectional motion in the unipolar section, the bipolar orientations in the bundle mean that it is possible for either motor to drive motion in either direction. In this paper we use a multilane asymmetric simple exclusion process modeling approach to simulate and investigate phases of bidirectional motility in a minimal model of an antipolar MT bundle. In our model, EE cargos (particles) change direction on each MT with a turning rate Ω and there is switching between MTs in the bundle at the minus ends. At these ends, particles can hop between MTs with rate q1 on passing from a unipolar to a bipolar section (the obstacle-induced switching rate) or q2 on passing in the other direction (the end-induced switching rate). By a combination of numerical simulations and mean-field approximations, we investigate the distribution of particles along the MTs for different values of these parameters and of Θ, the overall density of particles within this closed system. We find that even if Θ is low, the system can exhibit a variety of phases with shocks in the density profiles near plus and minus ends caused by queuing of particles. We discuss how the parameters influence the type of particle that dominates active transport in the bundle.

  3. Tube bundle vibrations due to cross flow under the influence of turbulence

    Energy Technology Data Exchange (ETDEWEB)

    Popp, K.; Romberg, O. [Institute of Mechanics, University of Hannover (Germany)

    1998-10-01

    Tube bundles are often used in heat exchangers and chemical reactors. Besides of large heat transfer capacities and small pressure drops in the apparatus a safe design against vibration damages is demanded. For many years extensive investigations concerning the dynamical behaviour of tube bundles subjected to cross-flow have been carried out in the wind tunnel of the Institute of Mechanics at the University of Hannover. In the last years the investigations were concentrated on the experimental investigations of different flow excitation mechanisms in a fully flexible bundle as well as in a bundle with one single flexibly mounted tube in an otherwise fixed array with variable geometry and changing equilibrium position. The aim of the studies was the determination of the stability boundaries, i.e. the critical reduced fluid velocity depending on the reduced damping coefficient in a wide parameter region. Theoretical investigations of the stability behaviour on the basis of an one dimensional flow model as well as experimental investigations of the influence of turbulence on the stability boundaries have been carried out. Here, for certain tube bundle configurations an increased turbulence has a stabilizing effect and leads to a shift of the stability boundaries to higher velocities. The change of the turbulence was realised by using turbulence grids at the inlet of the bundles or thin Prandtl-tripwires at the tube surfaces. Flow visualization studies at the original experimental set-up under relevant Reynolds numbers give an impression of the flow pattern. At this time an investigation of the exciting fluid forces is carried out using a flexibly mounted pressure test tube. A survey about some recent investigations is given. (orig.)

  4. Dendritic bundling in layer I of granular retrosplenial cortex: intracellular labeling and selectivity of innervation.

    Science.gov (United States)

    Wyss, J M; Van Groen, T; Sripanidkulchai, K

    1990-05-01

    The extrinsic projections to and from the retrosplenial cortex have been studied in detail, but the intrinsic circuitry within this region has been characterized less completely. To further define the internal connections, small injections of the retrograde, fluorescent tracer Fluorogold were made into the retrosplenial cortex of the rat. These injections label neurons in layers II-V of the contralateral homotopic cortex. In layers III-V, the labeled neurons are present over an area much larger than the injection site, but in layer II neurons are labeled in a very precise homotopic pattern. Following these injections, only the neurons in layer II display heavily labeled apical dendrites, and these labeled dendrites form tight bundles in layer Ic and Ib of the cortex and spread out in layer Ia. An examination of Golgi-stained material demonstrates that most of the neurons in layer II are small pyramidal cells with 2-3 small basal dendrites and a single, large apical dendrite that arborizes extensively in layer Ia. To verify the structure of the layer II neurons, they were intracellularly filled with Lucifer yellow. Examination of these labeled cells confirms the observations from the Golgi-stained material and demonstrates that many apical dendrites of the layer II cells angle acutely, apparently to join a bundle and/or avoid an interbundle space. Tract tracing experiments demonstrate that the anteroventral nucleus of the thalamus appears to project selectively to the region containing the dendritic bundles, whereas intracortical projections appear to terminate in layers Ib and Ic in the 30-200 microns spaces between the bundles. Furthermore, the areas containing the bundles display dense AChE staining, but the interbundle spaces are almost free of AChE staining. These findings demonstrate a form of dendritic bundling that is input and output specific and may play an important role in the regulation of thalamic inputs to the cingulate cortex.

  5. Natriuretic peptides in cardiometabolic regulation and disease

    DEFF Research Database (Denmark)

    Zois, Nora E; Bartels, Emil D; Hunter, Ingrid

    2014-01-01

    these conditions can coexist and potentially lead to heart failure, a syndrome associated with a functional natriuretic peptide deficiency despite high circulating concentrations of immunoreactive peptides. Therefore, dysregulation of the natriuretic peptide system, a 'natriuretic handicap', might be an important...

  6. RESULTS OF INVESTIGATIONS ON THERMAL CHARACTERISTICS OF AIR HEATER BUNDLE MADE OF BIMETALLIC FINNED TUBES

    Directory of Open Access Journals (Sweden)

    V. B. Kuntysh

    2014-01-01

    Full Text Available The paper presents a scheme and description of a new aerodynamic stand that has a 300x300 mm cross-section operating channel. The stand is used for studying thermal and aerodynamic characteristics of bundles made of finned tubes of actual dimensions in crossflow. The paper provides results of an exploratory test pertaining to heat transfer and resistance of four row staggered bundle made of tubes with aluminium spiral fins having outside diameter of 26 mm which are used in the systems of ventilation, air-conditioning and heating of buildings and also in transport heat exchangers.

  7. Electrospinning preparation and properties of magnetic-photoluminescent bifunctional bistrand-aligned composite nanofibers bundles

    Science.gov (United States)

    Gai, Guangqing; Wang, Liyan; Dong, Xiangting; Zheng, Chunmei; Yu, Wensheng; Wang, Jinxian; Xiao, Xinfu

    2013-04-01

    Fe3O4/PVP//Eu(BA)3phen/PVP magnetic-photoluminescent bifunctional bistrand-aligned composite nanofibers bundles based on ferroferric oxide(Fe3O4) nanoparticles and europium complex Eu(BA)3phen (BA = benzoic acid) were fabricated via electrospinning by employing a homemade parallel axial electrospinning setup with the side by side dual spinnerets for the first time. The structures, morphology, and properties of the as-prepared products were investigated in detail by X-ray diffraction, field-emission scanning electron microscopy, energy dispersive spectroscopy, transmission electron microscopy (TEM), a fluorescence spectrometer, and a vibrating sample magnetometer. SEM analysis showed the average diameter of the individual-strand fiber of the bistrand-aligned composite nanofibers bundles was 200 ± 25 nm. TEM image demonstrated that Fe3O4 nanoparticles were only dispersed into one strand of the bistrand-aligned composite nanofibers bundles, and the average diameter of Fe3O4 nanoparticles was about 15 nm. Under the excitation of 274 nm ultraviolet light, Fe3O4/PVP//Eu(BA)3phen/PVP bistrand-aligned composite nanofibers bundles exhibited red emissions of predominant peaks at 592 and 616 nm, which were respectively attributed to the 5D0 → 7F1 and 5D0 → 7F2 transitions of Eu3+ ions. The fluorescence intensity of the bistrand-aligned composite nanofibers bundles was higher than that of Fe3O4/Eu(BA)3phen/PVP composite nanofibers, and was decreased with the increase of the amounts of Fe3O4 nanoparticles. The saturation magnetizations of the bistrand-aligned composite nanofibers bundles and the Fe3O4/Eu(BA)3phen/PVP composite nanofibers were about equal when the two nanostructures contained the same mass ratios of Fe3O4 nanoparticles, but the saturation magnetizations of the bistrand-aligned composite nanofibers bundles were increased with the increase of the amounts of Fe3O4 nanoparticles. The new type Fe3O4/PVP//Eu(BA)3phen/PVP bistrand-aligned composite nanofibers

  8. Preparation of porcupine-like Bi2O3 needle bundles by anodic oxidation of bismuth

    OpenAIRE

    Sopha, Hanna; Podzemná, Veronika; Hromádko, Luděk; Macák, Jan

    2017-01-01

    A new Bi2O3 structure resembling bundles of needles was prepared by anodic oxidation of a bismuth substrate in H2SO4 electrolyte followed by annealing in air. Needle growth occurred on the timescale of minutes. The resulting porcupine-like needle bundles were characterized using SEM and XRD before and after annealing. The as-grown needles consisted of bismuth aqua sulfate hydroxide; however, upon annealing at 250 °C in air, tetragonal β-Bi2O3 was produced without any morphological change.

  9. Evaluation of CHF experimental data for non-square lattice 7-rod bundles

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Dae Hyun; Yoo, Y. J.; Kim, K. K.; Zee, S. Q

    2001-01-01

    A series of CHF experiments are conducted for 7-rod hexagonal test bundles in order to investigate the CHF characteristics of self-sustained square finned (SSF) rod bundles. The experiments are performed in the freon-loop and water-loop located at IPPE in Russia, and 609 data of freon-12 and 229 data of water are obtained from 7 kinds of test bundles classified by the combination of heated length and axial/radial power distributions. As the result of the evaluation of four representative CHF correlations, the EPRI-1 correlation reveals good prediction capability for SSF test bundles. The inlet parameter CHF correlation suggested by IPPE calculates the mean and the standard deviation of P/M for uniformly heated test bundles as 1.002 and 0.049, respectively. In spite of its excellent accuracy, the correlation has a discontinuity point at the boundary between the low velocity and high velocity conditions. KAERI's inlet parameter correlation eliminates this defect by introducing the complete evaporation model at low velocity condition, and calculates the mean and standard deviation of P/M as 0.095 and 0.062 for uniformly heated 496 data points, respectively. The mean/standard deviation of local parameter CHF correlations suggested by IPPE and KAERI are evaluated as 1.023/0.178 and 1.002/0.158, respectively. The inlet parameter correlation developed from uniformly heated test bundles tends to under-predict CHF about 3% for axially non-uniformly heated test bundles. On the other hand, the local parameter correlation reveals large scattering of P/M, and requires re-optimization of the correlation for non-uniform axial power distributions. As the result of the analysis of experimental data, it reveals that the correction model of axial power shapes suggested by IPPE is applicable to the inlet parameter correlations. For the test bundle of radial non-uniform power distribution, the physically unexpected results are obtained at some experimental conditions. In addition

  10. Frobenius Stratification of Moduli Spaces of Vector Bundles in Positive Characteristic

    OpenAIRE

    Li, Lingguang

    2016-01-01

    Let $X$ be a smooth projective curve of genus $g(X)\\geq 1$ over an algebraically closed field $k$ of characteristic $p>0$ and $F_X:X\\rightarrow X$ be the absolute Frobenius morphism. Let $\\M^s_X(r,d)$ be the moduli space of stable vector bundles of rank $r$ and degree $d$ on $X$. We study the Frobenius stratification of $\\M^s_X(r,d)$ in terms of Harder-Narasimhan polygons of Frobenius pull backs of stable vector bundles and get the irreducibility, smoothness and dimension of Frobenius strata ...

  11. Absent right bundle branch block: Is it a clue of pre-excitation in Ebstein's anomaly?

    Science.gov (United States)

    Gangurde, Pranil Bhalchandra; Tidake, Abhay; Shah, Hetan; Mahajan, Ajay; Lokhandwala, Yash; Nathani, Pratap

    2016-09-01

    A 14-year-old male with a history of symptomatic tachycardia was referred for ablation. Sinus rhythm electrocardiogram was not showing any pre-excitation. Tachycardia episode was showing antidromic tachycardia with left bundle branch block morphology. Echocardiographic examination was showing Ebstein's anomaly with septal tricuspid leaflet displaced 24mm apically. The right bundle branch block (RBBB) was concealed during sinus rhythm. The RBBB was revealed with ablation of right posterior atriofascicular accessory pathway. Copyright © 2015 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.

  12. Transient right bundle branch block in a patient with acute pulmonary embolism.

    Science.gov (United States)

    Gonzva, Jonathan; Viard, François-Valéry; Jost, Daniel; Lefort, Hugues; Tourtier, Jean-Pierre

    We report the case of an 86-year-old man found at home with acute chest pain and dyspnea. He presented some episodes of left chest pain combined with dyspnea. The physical examination revealed crackling sounds on the bases of the lungs without other anomalies. Electrocardiograms revealed a transient and complete right bundle branch block with inverted T waves in leads V1, V2, and V3. He was diagnosed with a proximal bilateral acute pulmonary embolism without acute cor pulmonale. We describe a case of a transient bundle branch block, without tachycardia or acute cor pulmonale, revealing a pulmonary embolism. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Masquerading bundle branch block as a presenting manifestation of complete atrioventricular block that caused syncope.

    Science.gov (United States)

    Jiao, Zhenyu; Tian, Ying; Yang, Xinchun; Liu, Xingpeng

    2017-10-01

    A 59-year-old male patient was admitted with the main complaints of stuffiness and shortness of breath. An ECG from precordial leads on admission showed masquerading bundle branch block. Syncope frequently occurred after admission. During syncope episodes, ECG telemetry showed that the syncope was caused by intermittent complete atrioventricular block, with the longest RR interval lasting for 4.36 s. At the gap of syncope, ECG showed complete right bundle branch block accompanied by alternation of left anterior fascicular block and left posterior fascicular block. The patient was implanted with a dual-chamber permanent pacemaker. Follow-up of 9 months showed no reoccurrence of syncope.

  14. Special features of right bundle branch block in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia.

    Science.gov (United States)

    Peters, Stefan; Trümmel, Martina; Koehler, Brigitte

    2012-05-17

    We searched for special features in patients with complete and incomplete right bundle branch block diagnosed as having arrhythmogenic right ventricular cardiomyopathy/dysplasia. Whether right bundle branch block is a frequent finding in arrhythmogenic right ventricular cardiomyopathy should be studied. The question is whether special features exist such as T-wave inversions, localized right precordial QRS prolongation and r'/s ratiobundle branch block is characterized by r'/s ratiobundle branch block is characterized by ST segment elevation in right precordial leads but not by T wave inversions ≥ V4. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  15. Bundle-branch reentry ventricular tachycardia after transcatheter aortic valve replacement

    Directory of Open Access Journals (Sweden)

    Adriana de la Rosa Riestra

    2015-09-01

    Full Text Available An 83-year-old male suffering from severe symptomatic aortic valve stenosis received an implant of a biological aortic prosthesis through the femoral artery without complications. Seven days after dischargement he experienced a syncope. The patient was wearing an ECG holter monitor that day, which showed a wide QRS complex tachycardia of 300 beats per minute. The electrophysiological study revealed a bundle-branch reentry ventricular tachycardia as the cause of the syncope. Radio-frequency was applied on the right-bundle branch. Twelve months later, the patient has remained asymptomatic.

  16. Spinor Structure of P-Oriented Space, Kustaanheimo-Stifel and Hopf Bundle - Connection between Formalisms

    OpenAIRE

    Red'kov, V. M.

    2011-01-01

    In the work some relations between three techniques, Hopf's bundle, Kustaanheimo-Stiefel's bundle, 3-space with spinor structure have been examined. The spinor space is viewed as a real space that is minimally (twice as much) extended in comparison with an ordinary vector 3-space: at this instead of 2\\pi-rotation now only 4\\pi-rotation is taken to be the identity transformation in the geometrical space. With respect to a given P-orientation of an initial unextended manyfold, vector or pseudov...

  17. Evaluation of nonequilibrium effects in bundle dispersed-flow film boiling. [PWR; BWR

    Energy Technology Data Exchange (ETDEWEB)

    Morris, D.G.; Mullins, C.B.; Yoder, G.L.

    1983-01-01

    The effects of thermodynamic nonequilibrium in dispersed flow film boiling heat transfer are examined. Steady-state and transient rod-bundle data are used to evaluate several empirical heat-transfer models commonly employed to predict post-CHF behavior. The models that account for thermodynamic nonequilibrium perform adequately, while those that ignore nonequilibrium effects incur errors in wall superheat as high as 190/sup 0/K. Nonequilibrium effects can also be treated by explicitly modeling the phenomena. The thermal-hydraulic code COBRA-TF employs this approach. Using bundle data, the models in the code are evaluated. Analysis suggests that the interfacial heat transfer is overpredicted.

  18. 3-D slug flow heat transfer analysis of coupled coolant cells in finite LMFBR bundles

    Energy Technology Data Exchange (ETDEWEB)

    Wong, C.N.; Wolf, L.

    1978-02-01

    A three-dimensional single region slug flow heat transfer analysis for finite LMFBR rod bundles using a classical analytical solution method has been performed. According to the isolated single cell analysis, the results show that the peripheral clad temperature variation as well as the thermal entrance length are strongly dependent upon the degree of irregularity displayed by various coolant geometries. Since under the present LMFBR conditions, fully-developed temperature fields may hardly be established in such characteristic rod bundle regions, a 3-D heat transfer analysis seems to be mandatory. This implies that the results of fully developed heat transfer analyses are by far too conservative.

  19. Boiling on a tube bundle: heat transfer, pressure drop and flow patterns

    Energy Technology Data Exchange (ETDEWEB)

    Royen Van, E.

    2011-11-15

    The complexity of two-phase flow boiling on a tube bundle presents many challenges to the understanding of the physical phenomena taking place. It is important to quantify these numerous heat flow mechanisms in order to better describe the performance of tube bundles as a function of the operational conditions. In the present study, the bundle boiling facility at the Laboratory of Heat and Mass Transfer (LTCM) was modified to obtain high-speed videos to characterise the two-phase regimes and some bubble dynamics of the boiling process. It was then used to measure heat transfer on single tubes and in bundle boiling conditions. Pressure drop measurements were also made during adiabatic and diabatic bundle conditions. New enhanced boiling tubes from Wolverine Tube Inc. (Turbo-B5) and the Wieland-Werke AG (Gewa-B5) were investigated using R134a and R236fa as test fluids. The tests were carried out at saturation temperatures T{sub sat} of 5 °C and 15 °C, mass flow rates from 4 to 35 kg/m{sup 2}s and heat fluxes from 15 to 70 kW/m{sup 2}, typical of actual operating conditions. The flow pattern investigation was conducted using visual observations from a borescope inserted in the middle of the bundle. Measurements of the light attenuation of a laser beam through the intertube two-phase flow and local pressure fluctuations with piezo-electric pressure transducers were also taken to further help in characterising the complex flow. Pressure drop measurements and data reduction procedures were revised and used to develop new, improved frictional pressure drop prediction methods for adiabatic and diabatic two-phase conditions. The physical phenomena governing the enhanced tube evaporation process and their effects on the performance of tube bundles were investigated and insight gained. A new method based on a theoretical analysis of thin film evaporation was used to propose a new correlating parameter. A large new database of local heat transfer coefficients were obtained

  20. Chemical Synthesis of Antimicrobial Peptides.

    Science.gov (United States)

    Münzker, Lena; Oddo, Alberto; Hansen, Paul R

    2017-01-01

    Solid-phase peptide synthesis (SPPS) is the method of choice for chemical synthesis of peptides. In this nonspecialist review, we describe commonly used resins, linkers, protecting groups, and coupling reagents in 9-fluorenylmethyloxycarbonyl (Fmoc) SPPS. Finally, a detailed protocol for manual Fmoc SPPS is presented.