WorldWideScience

Sample records for bumps precision extraction

  1. Calibration of BPCE.41801 and SPS extraction bump in LSS4

    CERN Document Server

    Catalan-Lasheras, N; Jones, O R; Papis, J P; Wenninger, J; CERN. Geneva. AB Department

    2003-01-01

    The Large aperture stripline coupler beam position monitor BPCE.41801 was calibrated using the LHC beam in the SPS for different proton intensities corresponding to different MOPOS gains. A polynomial correction of the data provided a correction on the absolute position to the 0.5 mm level in the large range of interest. The powering of the newly installed extraction bumper system was then checked against this monitor.

  2. precise delta extraction scheme for reprogramming of wireless

    African Journals Online (AJOL)

    eobe

    Our approach involves the use of a novel algorithm based on SET theory and the ... In addition, we developed a set of metrics that relays ... in the amount of memory space used during reprogramming processes. .... software tool and set of metrics for extracting precise ..... “A dynamic operating system for sensor nodes,” in.

  3. Creep characterization of solder bumps using nanoindentation

    Science.gov (United States)

    Du, Yingjie; Liu, Xiao Hu; Fu, Boshen; Shaw, Thomas M.; Lu, Minhua; Wassick, Thomas A.; Bonilla, Griselda; Lu, Hongbing

    2017-08-01

    Current nanoindentation techniques for the measurement of creep properties are applicable to viscoplastic materials with negligible elastic deformations. A new technique for characterization of creep behavior is needed for situations where the elastic deformation plays a significant role. In this paper, the effect of elastic deformation on the determination of creep parameters using nanoindentation with a self-similar nanoindenter tip is evaluated using finite element analysis (FEA). It is found that the creep exponent measured from nanoindentation without taking into account of the contribution of elastic deformation tends to be higher than the actual value. An effective correction method is developed to consider the elastic deformation in the calculation of creep parameters. FEA shows that this method provides accurate creep exponent. The creep parameters, namely the creep exponent and activation energy, were measured for three types of reflowed solder bumps using the nanoindentation method. The measured parameters were verified using FEA. The results show that the new correction approach allows extraction of creep parameters with precision from nanoindentation data.

  4. Optimization of Indium Bump Morphology for Improved Flip Chip Devices

    Science.gov (United States)

    Jones, Todd J.; Nikzad, Shouleh; Cunningham, Thomas J.; Blazejewski, Edward; Dickie, Matthew R.; Hoenk, Michael E.; Greer, Harold F.

    2011-01-01

    Flip-chip hybridization, also known as bump bonding, is a packaging technique for microelectronic devices that directly connects an active element or detector to a substrate readout face-to-face, eliminating the need for wire bonding. In order to make conductive links between the two parts, a solder material is used between the bond pads on each side. Solder bumps, composed of indium metal, are typically deposited by thermal evaporation onto the active regions of the device and substrate. While indium bump technology has been a part of the electronic interconnect process field for many years and has been extensively employed in the infrared imager industry, obtaining a reliable, high-yield process for high-density patterns of bumps can be quite difficult. Under the right conditions, a moderate hydrogen plasma exposure can raise the temperature of the indium bump to the point where it can flow. This flow can result in a desirable shape where indium will efficiently wet the metal contact pad to provide good electrical contact to the underlying readout or imager circuit. However, it is extremely important to carefully control this process as the intensity of the hydrogen plasma treatment dramatically affects the indium bump morphology. To ensure the fine-tuning of this reflow process, it is necessary to have realtime feedback on the status of the bumps. With an appropriately placed viewport in a plasma chamber, one can image a small field (a square of approximately 5 millimeters on each side) of the bumps (10-20 microns in size) during the hydrogen plasma reflow process. By monitoring the shape of the bumps in real time using a video camera mounted to a telescoping 12 magnifying zoom lens and associated optical elements, an engineer can precisely determine when the reflow of the bumps has occurred, and can shut off the plasma before evaporation or de-wetting takes place.

  5. The bumps on the hippocampus

    Science.gov (United States)

    Gao, Yi; Ver Hoef, Lawrence

    2016-03-01

    The hippocampus has been the focus of more imaging research than any other subcortical structure in the human brain. However a feature that has been almost universally overlooked are the bumpy ridges on the inferior aspect of the hippocampus, which we refer to as hippocampal dentation. These bumps arise from folds in the CA1 layer of Ammon's horn. Similar to the folding of the cerebral cortex, hippocampal dentation allows for greater surface area in a confined space. However, while quantitative studies of radiologic brain images have been advancing for decades, examining numerous approaches to hippocampal segmentation and morphology analysis, virtually all published 3D renderings of the hippocampus show the under surface to be quite smooth or mildly irregular; we have rarely seen the characteristic bumpy structure in the reconstructed 3D scene, one exception being the 9.4T postmortem study. This is presumably due to the fact that, based on our experience with high resolution images, there is a dramatic degree of variability in hippocampal dentation between individuals from very smooth to highly dentated. An apparent question is, does this indicate that this specific morphological signature can only be captured using expensive ultra-high field techniques? Or, is such information buried in the data we commonly acquire, awaiting a computation technique that can extract and render it clearly? In this study, we propose a super-resolution technique that captures the fine scale morphometric features of the hippocampus based on common T1-weighted 3T MR images.

  6. precise delta extraction scheme for reprogramming of wireless

    African Journals Online (AJOL)

    eobe

    pattern of the Execution Link File (ELF) structure to extract delta from two distinct firmware (original and the structure to extract ... similar utilities referred in literature, shows an appreciable capacity to reduce energy consumption rate as well as on rate as well as ..... D. Cullar and K. Pister, “System architecture directions for.

  7. Precision of the CAESAR scan-extracted measurements

    NARCIS (Netherlands)

    Robinette, K.M.; Daanen, H.A.M.

    2006-01-01

    Three-dimensional (3D) body scanners are increasingly used to derive 1D body dimensions from 3D whole body scans for instance, as input for clothing grading systems to make made-to-measure clothing or for width and depth dimensions of a seated workstation. In this study, the precision of the

  8. Precision of the CAESAR scan-extracted measurements

    NARCIS (Netherlands)

    Robinette, Kathleen M.; Daanen, Hein A M

    Three-dimensional (3D) body scanners are increasingly used to derive 1D body dimensions from 3D whole body scans for instance, as input for clothing grading systems to make made-to-measure clothing or for width and depth dimensions of a seated workstation. In this study, the precision of the

  9. The Effects of Campus Bump on Drivers’ Fixation Dispersion and Speed Reduction

    Directory of Open Access Journals (Sweden)

    Qian Xu

    2015-01-01

    Full Text Available To evaluate the effects of campus speed bumps on drivers’ speed and fixation distribution, a quasinaturalistic driving test was conducted on a Chinese campus. Seven randomly selected drivers, wearing the Dikablis eye tracking devices, were required to drive an OPEL SUV passing the speed bumps. The area close to the bump was divided into ten subsegments (15 m for each one. The degree of fixation dispersion within each subsegment was defined as the distance from each subcenter to the whole fixation center. All traffic data were recorded using mounted camera, and the trajectories were extracted in Matlab. The speed and trajectory data was divided into two groups: the before group for bump-free case and the after group for a 5 cm bump case. The observational before-after analysis shows statistical significance between the two cases. The individual vehicular speed analysis reveals that bump reduces nearly 60% of vehicles’ speeds to a certain extent within the distance from 30 m upstream to 15 m downstream. The drivers’ fixation points begin to disperse 30–45 m before they see the bump, and it falls back to normal level 15–30 m downstream of the bump. These findings will help engineers install speed bumps at the most appropriate locations.

  10. HANFORD WASTE TANK BUMP ACCIDENT & CONSEQUENCE ANALYSIS

    Energy Technology Data Exchange (ETDEWEB)

    MEACHAM, J.E.

    2005-02-22

    Postulated physical scenarios leading to tank bumps were examined. A combination of a substantial supernatant layer depth, supernatant temperatures close to saturation, and high sludge temperatures are required for a tank bump to occur. Scenarios postulated at various times for sludge layers lacking substantial supernatant, such as superheat within the layer and fumarole formation leading to a bump were ruled out.

  11. Beam Based Calibration of Slow Orbit Bump in the NSLS Booster

    Energy Technology Data Exchange (ETDEWEB)

    Yang, X.; Shaftan, T.; Rose, J.

    2009-05-04

    The orbit bumps in NSLS booster are used to move the beam orbit within 2mm of the extraction septum aperture on a time scale of millisecond at extraction in order to reduce the requirement on the amplitude of the fast extraction kicker. This may cause charge losses since before extraction, the beam stays on the distorted orbit for thousands of revolutions. In order to find the optimal orbit bump setpoint, which brings the maximum distortion at the extraction position and minimum distortions everywhere else, we developed an extraction model and performed an experiment to validate it. Afterwards, the model was applied to optimize the extraction process.

  12. Process for Patterning Indium for Bump Bonding

    Science.gov (United States)

    Denis, Kevin

    2012-01-01

    An innovation was created for the Cosmology Large Angular Scale Surveyor for integration of low-temperature detector chips with a silicon backshort and a silicon photonic choke through flipchip bonding. Indium bumps are typically patterned using liftoff processes, which require thick resist. In some applications, it is necessary to locate the bumps close to high-aspect-ratio structures such as wafer through-holes. In those cases, liftoff processes are challenging, and require complicated and time-consuming spray coating technology if the high-aspect-ratio structures are delineated prior to the indium bump process. Alternatively, processing the indium bumps first is limited by compatibility of the indium with subsequent processing. The present invention allows for locating bumps arbitrarily close to multiple-level high-aspect-ratio structures, and for indium bumps to be formed without liftoff resist. The process uses the poor step coverage of indium deposited on a silicon wafer that has been previously etched to delineate the location of the indium bumps. The silicon pattern can be processed through standard lithography prior to adding the high-aspect-ratio structures. Typically, high-aspectratio structures require a thick resist layer so this layer can easily cover the silicon topography. For multiple levels of topography, the silicon can be easily conformally coated through standard processes. A blanket layer of indium is then deposited onto the full wafer; bump bonding only occurs at the high points of the topography.

  13. A Simple and Rapid Data Extraction Method for the Precision Aspheric Optical Surface Height

    Science.gov (United States)

    Xing, Guohua; Peng, Yunfeng; Su, Xing

    2017-10-01

    Nowadays, the application of aspheric optics is becoming more and more popular in the precision optical engineering field. Therefore, it urges the rapid development of the precision machining and measuring technology. Generally, the aspheric optical component is measured by the interferometer. The underlying question is that the figure output by interferometer can’t be always recognized by other analysis software or program though the interferometer has its own unique data processing system. In this paper, a robust, rapid and simple method is presented to interpret the surface height data of the precision machined aspheric optical surface. The optical surface is measured by interferometer. The result figure is split into two parts, one of which is the interferogram picture of the whole aspheric optical surface and the other is the colour reference column indicating the height value. The ratios of the red (R), green (G) and blue (B) are analysed based on the middle of the colour reference column, and the corresponding relationship between the colours and surface height is established and looked as a reference data base. Then the interferogram picture of the whole aspheric optical surface is also analysed and divided according to the red (R), green (G) and blue (B) colours. By comparing the ratios and values of RGB colour, the aspheric optical surface height can be extracted approximately. The feasibility of this method was approved by the extraction processing experiment of a polished aspheric optical surface.

  14. Recent advances in understanding the reminiscence bump

    DEFF Research Database (Denmark)

    Koppel, Jonathan; Rubin, David C.

    2016-01-01

    The reminiscence bump is the increased proportion of autobiographical memories from youth and early adulthood observed in adults over 40. It is one of the most robust findings in autobiographical-memory research. Although described as a single period from which there are more memories, a recent m...... stress. Furthermore, it points to the need to develop theories of autobiographical memory that account for this flexibility in the memories retrieved.......The reminiscence bump is the increased proportion of autobiographical memories from youth and early adulthood observed in adults over 40. It is one of the most robust findings in autobiographical-memory research. Although described as a single period from which there are more memories, a recent...... the bump obtained when important memories are requested. The bump obtained in response to odor cues is even earlier. This variation in the size and temporal location of the reminiscence bump argues for theories based primarily on retrieval rather than encoding and retention, which most current theories...

  15. Precise on-machine extraction of the surface normal vector using an eddy current sensor array

    Science.gov (United States)

    Wang, Yongqing; Lian, Meng; Liu, Haibo; Ying, Yangwei; Sheng, Xianjun

    2016-11-01

    To satisfy the requirements of on-machine measurement of the surface normal during complex surface manufacturing, a highly robust normal vector extraction method using an Eddy current (EC) displacement sensor array is developed, the output of which is almost unaffected by surface brightness, machining coolant and environmental noise. A precise normal vector extraction model based on a triangular-distributed EC sensor array is first established. Calibration of the effects of object surface inclination and coupling interference on measurement results, and the relative position of EC sensors, is involved. A novel apparatus employing three EC sensors and a force transducer was designed, which can be easily integrated into the computer numerical control (CNC) machine tool spindle and/or robot terminal execution. Finally, to test the validity and practicability of the proposed method, typical experiments were conducted with specified testing pieces using the developed approach and system, such as an inclined plane and cylindrical and spherical surfaces.

  16. Defect Inspection of Flip Chip Solder Bumps Using an Ultrasonic Transducer

    Directory of Open Access Journals (Sweden)

    Lei Su

    2013-11-01

    Full Text Available Surface mount technology has spurred a rapid decrease in the size of electronic packages, where solder bump inspection of surface mount packages is crucial in the electronics manufacturing industry. In this study we demonstrate the feasibility of using a 230 MHz ultrasonic transducer for nondestructive flip chip testing. The reflected time domain signal was captured when the transducer scanning the flip chip, and the image of the flip chip was generated by scanning acoustic microscopy. Normalized cross-correlation was used to locate the center of solder bumps for segmenting the flip chip image. Then five features were extracted from the signals and images. The support vector machine was adopted to process the five features for classification and recognition. The results show the feasibility of this approach with high recognition rate, proving that defect inspection of flip chip solder bumps using the ultrasonic transducer has high potential in microelectronics packaging.

  17. Automated DEM extraction in digital aerial photogrammetry: precisions and validation for mass movement monitoring

    Directory of Open Access Journals (Sweden)

    A. Pesci

    2005-06-01

    Full Text Available Automated procedures for photogrammetric image processing and Digital Elevation Models (DEM extraction yield high precision terrain models in a short time, reducing manual editing; their accuracy is strictly related to image quality and terrain features. After an analysis of the performance of the Digital Photogrammetric Workstation (DPW 770 Helava, the paper compares DEMs derived from different surveys and registered in the same reference system. In the case of stable area, the distribution of height residuals, their mean and standard deviation values, indicate that the theoretical accuracy is achievable automatically when terrain is characterized by regular morphology. Steep slopes, corrugated surfaces, vegetation and shadows can degrade results even if manual editing procedures are applied. The comparison of multi-temporal DEMs on unstable areas allows the monitoring of surface deformation and morphological changes.

  18. The reminiscence bump in autobiographical memory and for public events

    DEFF Research Database (Denmark)

    Koppel, Jonathan; Berntsen, Dorthe

    2016-01-01

    The reminiscence bump has been found for both autobiographical memories and memories of public events. However, there have been few comparisons of the bump across each type of event. In the current study, therefore, we compared the bump for autobiographical memories versus the bump for memories...... of public events. We did so between-subjects, through two cueing methods administered within-subjects, the cue word method and the important memories method. For word-cued memories, we found a similar bump from ages 5 to 19 for both types of memories. However, the bump was more pronounced...... for autobiographical memories. For most important memories, we found a bump from ages 20 to 29 in autobiographical memory, but little discernible age pattern for public events. Rather, specific public events (e.g., the Fall of the Berlin Wall) dominated recall, producing a chronological distribution characterised...

  19. Bump formation in the runaway electron tail

    CERN Document Server

    Decker, J; Fülöp, T

    2015-01-01

    Runaway electrons are generated in a magnetized plasma when the parallel electric field exceeds a critical value. For such electrons with energies typically reaching tens of MeV, the Abraham-Lorentz-Dirac (ALD) radiation force, in reaction to the synchrotron emission, is significant and can be the dominant process limiting the electron acceleration. The effect of the ALD-force on runaway electron dynamics in a homogeneous plasma is investigated using the relativistic finite-difference Fokker-Planck codes LUKE [Decker & Peysson, Report EUR-CEA-FC-1736, Euratom-CEA, (2004)] and CODE [Landreman et al, Comp. Phys. Comm. 185, 847 (2014)]. Under the action of the ALD force, we find that a bump is formed in the tail of the electron distribution function if the electric field is sufficiently large. We also observe that the energy of runaway electrons in the bump increases with the electric field amplitude, while the population increases with the bulk electron temperature. The presence of the bump divides the elec...

  20. A Technique for Extracting Highly Precise Photometry for the Two-Wheeled Kepler Mission

    OpenAIRE

    Vanderburg, Andrew; Johnson, John Asher

    2014-01-01

    The original Kepler mission achieved high photometric precision thanks to ultra-stable pointing enabled by use of four reaction wheels. The loss of two of these reaction wheels reduced the telescope's ability to point precisely for extended periods of time, and as a result, the photometric precision has suffered. We present a technique for generating photometric light curves from pixel-level data obtained with the two-wheeled extended Kepler mission, K2. Our photometric technique accounts for...

  1. Thermohydrodynamic analysis of airfoil bearing based on bump foil structure

    Directory of Open Access Journals (Sweden)

    S.Y. Maraiy

    2016-09-01

    Full Text Available The load carrying capacity of the gas foil bearing depends on the material properties and the configuration of the underlying bump strip’s structure. This paper presents three different cases for selecting the dimensions of the foil bearing to guarantee the highest possible load carrying capacity. It focuses on three main parameters that affect the compliance number; these parameters are the length of bump in θ direction, the pitch of bump foil, and the thickness of bump foil. It also studies the effect of changing these parameters on load carrying capacity according to both isothermal and thermohydrodynamic approaches.

  2. A novel method for direct solder bump pull testing using lead-free solders

    Science.gov (United States)

    Turner, Gregory Alan

    This thesis focuses on the design, fabrication, and evaluation of a new method for testing the adhesion strength of lead-free solders, named the Isotraction Bump Pull method (IBP). In order to develop a direct solder joint-strength testing method that did not require customization for different solder types, bump sizes, specific equipment, or trial-and-error, a combination of two widely used and accepted standards was created. First, solder bumps were made from three types of lead free solder were generated on untreated copper PCB substrates using an in-house fabricated solder bump-on-demand generator, Following this, the newly developed method made use of a polymer epoxy to encapsulate the solder bumps that could then be tested under tension using a high precision universal vertical load machine. The tests produced repeatable and predictable results for each of the three alloys tested that were in agreement with the relative behavior of the same alloys using other testing methods in the literature. The median peak stress at failure for the three solders tested were 2020.52 psi, 940.57 psi, and 2781.0 psi, and were within one standard deviation of the of all data collected for each solder. The assumptions in this work that brittle fracture occurred through the Intermetallic Compound layer (IMC) were validated with the use of Energy-Dispersive X-Ray Spectrometry and high magnification of the fractured surface of both newly exposed sides of the test specimens. Following this, an examination of the process to apply the results from the tensile tests into standard material science equations for the fracture of the systems was performed..

  3. ICHEP 2016: to b(ump) or not to b(ump)

    CERN Multimedia

    2016-01-01

    This week I’m in Chicago for the 38th International Conference on High Energy Physics, ICHEP 2016, hosted this year by the US particle physics community. While it became clear at the conference that the famous 750 GeV bump has flatlined, there’s been a wealth of physics from CERN and around the world.   Everyone in their heart felt that the bump would turn out to be no more than a statistical fluctuation, while secretly hoping that it would be something new. Even the designer of the ICHEP 2016 logo cleverly hid a bump with a subtle question mark in the Chicago skyline – appropriately enough in Anish Kapoor’s mysterious ‘Cloud Gate’ sculpture. That question mark has now been resolved. Kapoor’s sculpture returns to being just that, and the search for new physics goes on albeit further constrained as theorists revealed in the 400+ papers in the wake of the bump discussion. The highlight from CERN was undoubtedly the spectacular pe...

  4. The reminiscence bump reconsidered: children's prospective life stories show a bump in young adulthood.

    Science.gov (United States)

    Bohn, Annette; Berntsen, Dorthe

    2011-02-01

    The reminiscence bump-the reporting of more memories from young adulthood than from other stages of life-is considered a hallmark of autobiographical memory research. The most prevalent explanations for this effect assume that events in young adulthood are favored because of the way they are encoded and maintained in long-term memory. Here we show that a similar increase of events in early adulthood is found when children narrate their personal futures. In Study 1, children wrote their future life stories. The events in these life stories were mostly life-script events, and their distribution showed a clear bump in young adulthood. In Study 2, children were prompted by word cues to write down events from their future lives. The events generated consisted mostly of non-life-script events, and those events did not show a bump in young adulthood. Our findings challenge prevailing explanations of the reminiscence bump and suggest that the cultural life script forms an overarching organizational principle for autobiographical memories and future representations across the life span.

  5. Cascading reminiscence bumps in popular music.

    Science.gov (United States)

    Krumhansl, Carol Lynne; Zupnick, Justin Adam

    2013-10-01

    Autobiographical memories are disproportionately recalled for events in late adolescence and early adulthood, a phenomenon called the reminiscence bump. Previous studies on music have found autobiographical memories and life-long preferences for music from this period. In the present study, we probed young adults' personal memories associated with top hits over 5-and-a-half decades, as well as the context of their memories and their recognition of, preference for, quality judgments of, and emotional reactions to that music. All these measures showed the typical increase for music released during the two decades of their lives. Unexpectedly, we found that the same measures peaked for the music of participants' parents' generation. This finding points to the impact of music in childhood and suggests that these results reflect the prevalence of music in the home environment. An earlier peak occurred for 1960s music, which may be explained by its quality or by its transmission through two generations. We refer to this pattern of musical cultural transmission over generations as cascading reminiscence bumps.

  6. The Physics of Bump Drafting in Car Racing

    Science.gov (United States)

    Fiolhais, Miguel C. N.; Amor dos Santos, Susana

    2014-01-01

    The technique of bump drafting, also known as two-car drafting in motorsports, is analysed in the framework of Newtonian mechanics and simple aerodynamic drag forces. As an apparent unnatural effect that often pleases the enthusiasts of car racing, bump drafting provides a unique pedagogical opportunity for students to gain insights into the…

  7. Bump Bonding Using Metal-Coated Carbon Nanotubes

    Science.gov (United States)

    Lamb, James L.; Dickie, Matthew R.; Kowalczyk, Robert S.; Liao, Anna; Bronikowski, Michael J.

    2012-01-01

    Bump bonding hybridization techniques use arrays of indium bumps to electrically and mechanically join two chips together. Surface-tension issues limit bump sizes to roughly as wide as they are high. Pitches are limited to 50 microns with bumps only 8-14 microns high on each wafer. A new process uses oriented carbon nanotubes (CNTs) with a metal (indium) in a wicking process using capillary actions to increase the aspect ratio and pitch density of the connections for bump bonding hybridizations. It merges the properties of the CNTs and the metal bumps, providing enhanced material performance parameters. By merging the bumps with narrow and long CNTs oriented in the vertical direction, higher aspect ratios can be obtained if the metal can be made to wick. Possible aspect ratios increase from 1:1 to 20:1 for most applications, and to 100:1 for some applications. Possible pitch density increases of a factor of 10 are possible. Standard capillary theory would not normally allow indium or most other metals to be drawn into the oriented CNTs, because they are non-wetting. However, capillary action can be induced through the ability to fabricate oriented CNT bundles to desired spacings, and the use of deposition techniques and temperature to control the size and mobility of the liquid metal streams and associated reservoirs. This hybridization of two technologies (indium bumps and CNTs) may also provide for some additional benefits such as improved thermal management and possible current density increases.

  8. Two-Step Plasma Process for Cleaning Indium Bonding Bumps

    Science.gov (United States)

    Greer, Harold F.; Vasquez, Richard P.; Jones, Todd J.; Hoenk, Michael E.; Dickie, Matthew R.; Nikzad, Shouleh

    2009-01-01

    A two-step plasma process has been developed as a means of removing surface oxide layers from indium bumps used in flip-chip hybridization (bump bonding) of integrated circuits. The two-step plasma process makes it possible to remove surface indium oxide, without incurring the adverse effects of the acid etching process.

  9. Bonding and transferring of carbon nanotube bumps using magnetron sputtering

    Science.gov (United States)

    Fujino, Masahisa; Terasaka, Hidenori; Suga, Tadatomo

    2018-02-01

    Bump-shaped carbon nanotubes (CNTs) are expected as substitutional via/bump structures for electronic devices. Moreover, the resistivity of the interconnect between CNTs and metal is relatively higher than that of conventional interconnects. In this research, CNT bumps were bonded to a Au substrate by surface activated bonding (SAB) with Au magnetron sputtering, and the resistance of the CNT bumps was measured. As a result, the Au sputtered on CNT bumps can reduce the interconnect resistance because of the enlarging contact area of CNT/metal and also their conjugation. Moreover, the interconnect resistance of the SAB-processed CNT and Au substrate could be estimated from the difference between their interconnect structures.

  10. A precise study on effects that trigger alkaline hemicellulose extraction efficiency.

    Science.gov (United States)

    Hutterer, Christian; Schild, Gabriele; Potthast, Antje

    2016-08-01

    The conversion of paper-grade pulps into dissolving pulps requires efficient strategies and process steps to remove low-molecular noncellulosic macromolecules generally known as hemicelluloses. Current strategies include alkaline extractions and enzymatic treatments. This study focused on the evaluation of extraction efficiencies in alkaline extractions of three economically interesting hardwood species: beech (Fagus sylvatica), birch (Betula papyrifera), and eucalyptus (Eucalyptus globulus). Substrate pulps were subjected to alkaline treatments at different temperatures and alkalinities using white liquor as the alkali source, followed by analyses of both pulps and hemicellulose-containing extraction lyes. The extracted hardwood xylans have strong potential as an ingredient in the food and pharmaceutical industries. Subsequent analyses revealed strong dependencies of the extraction efficiencies and molar mass distributions of hemicelluloses on the process variables of temperature and effective alkalinity. The hemicellulose content of the initial pulps, the hardwood species, and the type of applied base played minor roles. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. The reminiscence bump reconsidered: Children's prospective life stories show a bump in young adulthood

    DEFF Research Database (Denmark)

    Bohn, Annette; Berntsen, Dorthe

    2011-01-01

    they are encoded and maintained in long-term memory. Here we show that a similar increase of events in early adulthood is found when children narrate their personal futures. In Study 1, children wrote their future life stories. The events in these life stories were mostly life-script events, and their distribution......Abstract The reminiscence bump—the reporting of more memories from young adulthood than from other stages of life—is considered a hallmark of autobiographical memory research. The most prevalent explanations for this effect assume that events in young adulthood are favored because of the way...... showed a clear bump in young adulthood. In Study 2, children were prompted by word cues to write down events from their future lives. The events generated consisted mostly of non-life-script events, and those events did not show a bump in young adulthood. Our findings challenge prevailing explanations...

  12. A flip chip process based on electroplated solder bumps

    Science.gov (United States)

    Salonen, J.; Salmi, J.

    1994-01-01

    Compared to wire bonding and TAB, flip chip technology using solder joints offers the highest pin count and packaging density and superior electrical performance. The chips are mounted upside down on the substrate, which can be made of silicon, ceramic, glass or - in some cases - even PCB. The extra processing steps required for chips are the deposition of a suitable thin film metal layer(s) on the standard Al pad and the formation of bumps. Also, the development of new fine line substrate technologies is required to utilize the full potential of the technology. In our bumping process, bump deposition is done by electroplating, which was chosen for its simplicity and economy. Sputter deposited molybdenum and copper are used as thin film layers between the aluminum pads and the solder bumps. A reason for this choice is that the metals can be selectively etched after bumping using the bumps as a mask, thus circumventing the need for a separate mask for etching the thin film metals. The bumps are electroplated from a binary Pb-Sn bath using a thick liquid photoresist. An extensively modified commercial flip chip bonder is used for alignment and bonding. Heat assisted tack bonding is used to attach the chips to the substrate, and final reflow joining is done without flux in a vacuum furnace.

  13. Lattice Hamiltonian approach to the massless Schwinger model. Precise extraction of the mass gap

    Energy Technology Data Exchange (ETDEWEB)

    Cichy, Krzysztof [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Poznan Univ. (Poland). Faculty of Physics; Kujawa-Cichy, Agnieszka [Poznan Univ. (Poland). Faculty of Physics; Szyniszewski, Marcin [Poznan Univ. (Poland). Faculty of Physics; Manchester Univ. (United Kingdom). NOWNano DTC

    2012-12-15

    We present results of applying the Hamiltonian approach to the massless Schwinger model. A finite basis is constructed using the strong coupling expansion to a very high order. Using exact diagonalization, the continuum limit can be reliably approached. This allows to reproduce the analytical results for the ground state energy, as well as the vector and scalar mass gaps to an outstanding precision better than 10{sup -6} %.

  14. How bumps on whale flippers delay stall: an aerodynamic model.

    Science.gov (United States)

    van Nierop, Ernst A; Alben, Silas; Brenner, Michael P

    2008-02-08

    Wind tunnel experiments have shown that bumps on the leading edge of model humpback whale flippers cause them to "stall" (i.e., lose lift dramatically) more gradually and at a higher angle of attack. Here we develop an aerodynamic model which explains the observed increase in stall angle. The model predicts that as the amplitude of the bumps is increased, the lift curve flattens out, leading to potentially desirable control properties. We find that stall delay is insensitive to the wavelength of the bumps, in accordance with experimental observations.

  15. Quality of scintillating fibres after hot bump shrinking

    CERN Document Server

    Rodrigues Cavalcante, Ana Barbara; Joram, Christian

    2016-01-01

    Shrinking the diameter of fibre bumps by a hot drawing tool requires to run the fibre through the hot tool over its full length, bearing the risk of a degradation of the fibre performance. In this study we demonstrated that the hot bump shrinking method has no visible effect on the optical attenuation length, the light yield following ionising radiation, the diameter, the mechanical stability and the integrity of the cladding. For the latter, even a small positive impact was observed.

  16. Performance of a LVL2 Trigger Feature Extraction Algorithm for the Precision Tracker.

    CERN Document Server

    Baines, J T M; Sivoklokov, S Yu

    1999-01-01

    An algorithm to search for isolated high pT tracks in the ATLAS precision tracker suitable for use in the LVL2 trigger is described. A histogramming method employing a Hough transform is used to select sets of points forming track candidates. For each selected set of points, fits are performed to all combinations of one point per detection plane. The best candidate is chosen on the basis of the fit residuals. The algorithm has been implemented in the t2scFex package of the ATRIG trigger simulation program and also for benchmarking studies in a stand-alone program SCTFEX. Efficiency, fake track rate and timing measurements are presented for a number of algorithm options.

  17. AstroImageJ: Image Processing and Photometric Extraction for Ultra-precise Astronomical Light Curves

    Science.gov (United States)

    Collins, Karen A.; Kielkopf, John F.; Stassun, Keivan G.; Hessman, Frederic V.

    2017-02-01

    ImageJ is a graphical user interface (GUI) driven, public domain, Java-based, software package for general image processing traditionally used mainly in life sciences fields. The image processing capabilities of ImageJ are useful and extendable to other scientific fields. Here we present AstroImageJ (AIJ), which provides an astronomy specific image display environment and tools for astronomy specific image calibration and data reduction. Although AIJ maintains the general purpose image processing capabilities of ImageJ, AIJ is streamlined for time-series differential photometry, light curve detrending and fitting, and light curve plotting, especially for applications requiring ultra-precise light curves (e.g., exoplanet transits). AIJ reads and writes standard Flexible Image Transport System (FITS) files, as well as other common image formats, provides FITS header viewing and editing, and is World Coordinate System aware, including an automated interface to the astrometry.net web portal for plate solving images. AIJ provides research grade image calibration and analysis tools with a GUI driven approach, and easily installed cross-platform compatibility. It enables new users, even at the level of undergraduate student, high school student, or amateur astronomer, to quickly start processing, modeling, and plotting astronomical image data with one tightly integrated software package.

  18. QCD Precision Measurements and Structure Function Extraction at a High Statistics, High Energy Neutrino Scattering Experiment: NuSOnG

    Energy Technology Data Exchange (ETDEWEB)

    Adams, T.; /Florida State U.; Batra, P.; /Columbia U.; Bugel, Leonard G.; /Columbia U.; Camilleri, Leslie Loris; /Columbia U.; Conrad, Janet Marie; /MIT; de Gouvea, A.; /Northwestern U.; Fisher, Peter H.; /MIT; Formaggio, Joseph Angelo; /MIT; Jenkins, J.; /Northwestern U.; Karagiorgi, Georgia S.; /MIT; Kobilarcik, T.R.; /Fermilab /Texas U.

    2009-06-01

    We extend the physics case for a new high-energy, ultra-high statistics neutrino scattering experiment, NuSOnG (Neutrino Scattering On Glass) to address a variety of issues including precision QCD measurements, extraction of structure functions, and the derived Parton Distribution Functions (PDFs). This experiment uses a Tevatron-based neutrino beam to obtain a sample of Deep Inelastic Scattering (DIS) events which is over two orders of magnitude larger than past samples. We outline an innovative method for fitting the structure functions using a parameterized energy shift which yields reduced systematic uncertainties. High statistics measurements, in combination with improved systematics, will enable NuSOnG to perform discerning tests of fundamental Standard Model parameters as we search for deviations which may hint of 'Beyond the Standard Model' physics.

  19. QCD Precision Measurements and Structure Function Extraction at a High Statistics, High Energy Neutrino Scattering Experiment:. NuSOnG

    Science.gov (United States)

    Adams, T.; Batra, P.; Bugel, L.; Camilleri, L.; Conrad, J. M.; de Gouvêa, A.; Fisher, P. H.; Formaggio, J. A.; Jenkins, J.; Karagiorgi, G.; Kobilarcik, T. R.; Kopp, S.; Kyle, G.; Loinaz, W. A.; Mason, D. A.; Milner, R.; Moore, R.; Morfín, J. G.; Nakamura, M.; Naples, D.; Nienaber, P.; Olness, F. I.; Owens, J. F.; Pate, S. F.; Pronin, A.; Seligman, W. G.; Shaevitz, M. H.; Schellman, H.; Schienbein, I.; Syphers, M. J.; Tait, T. M. P.; Takeuchi, T.; Tan, C. Y.; van de Water, R. G.; Yamamoto, R. K.; Yu, J. Y.

    We extend the physics case for a new high-energy, ultra-high statistics neutrino scattering experiment, NuSOnG (Neutrino Scattering On Glass) to address a variety of issues including precision QCD measurements, extraction of structure functions, and the derived Parton Distribution Functions (PDF's). This experiment uses a Tevatron-based neutrino beam to obtain a sample of Deep Inelastic Scattering (DIS) events which is over two orders of magnitude larger than past samples. We outline an innovative method for fitting the structure functions using a parametrized energy shift which yields reduced systematic uncertainties. High statistics measurements, in combination with improved systematics, will enable NuSOnG to perform discerning tests of fundamental Standard Model parameters as we search for deviations which may hint of "Beyond the Standard Model" physics.

  20. New Pulsed Orbit Bump Magnets for the Fermilab Booster Synchrotron

    CERN Document Server

    Lackey, James; John, Carson; Kashikhin, Vladimir; Makarov, Alexander; Prebys, Eric

    2005-01-01

    The beam from the Fermilab Linac is injected onto a bump in the closed orbit of the Booster Synchrotron where a carbon foil strips the electrons from the Linac’s negative ion hydrogen beam. Although the Booster itself runs at 15Hz, heat dissipation in the orbit bump magnets has been one limitation to the fraction of the cycles that can be used for beam. New, 0.28T pulsed window frame dipole magnets have been constructed that will fit into the same space as the old ones, run at the full repetition rate of the Booster, and provide a larger bump to allow a cleaner injection orbit. The new magnets use a high saturation flux density Ni-Zn ferrite in the yoke rather than laminated steel. The presented magnetic design includes two and three dimensional magnetic field calculations with eddy currents and ferrite nonlinear effects.

  1. Hanford Waste Tank Bump Accident and Consequence Analysis

    Energy Technology Data Exchange (ETDEWEB)

    BRATZEL, D.R.

    2000-06-20

    This report provides a new evaluation of the Hanford tank bump accident analysis and consequences for incorporation into the Authorization Basis. The analysis scope is for the safe storage of waste in its current configuration in single-shell and double-shell tanks.

  2. Do You Hear a Bump or a Hole?

    DEFF Research Database (Denmark)

    Serafin, Stefania; Turchet, Luca; Nordahl, Rolf

    2010-01-01

    In this paper, we present a preliminary experiment whose goal is to assess the role of temporal aspects in sonically simulating the act of walking on a bump or a hole. In particular, we investigate whether the timing between heel and toe and the timing between footsteps affects the perception of ...

  3. Structural integrity of power generating speed bumps made of concrete foam composite

    Science.gov (United States)

    Syam, B.; Muttaqin, M.; Hastrino, D.; Sebayang, A.; Basuki, W. S.; Sabri, M.; Abda, S.

    2018-02-01

    In this paper concrete foam composite speed bumps were designed to generate electrical power by utilizing the movements of commuting vehicles on highways, streets, parking gates, and drive-thru station of fast food restaurants. The speed bumps were subjected to loadings generated by vehicles pass over the power generating mechanical system. In this paper, we mainly focus our discussion on the structural integrity of the speed bumps and discuss the electrical power generating speed bumps in another paper. One aspect of structural integrity is its ability to support designed loads without breaking and includes the study of past structural failures in order to prevent failures in future designs. The concrete foam composites were used for the speed bumps; the reinforcement materials are selected from empty fruit bunch of oil palm. In this study, the speed bump materials and structure were subjected to various tests to obtain its physical and mechanical properties. To analyze the structure stability of the speed bumps some models were produced and tested in our speed bump test station. We also conduct a FEM-based computer simulation to analyze stress responses of the speed bump structures. It was found that speed bump type 1 significantly reduced the radial voltage. In addition, the speed bump is equipped with a steel casing is also suitable for use as a component component in generating electrical energy.

  4. Life story chapters, specific memories and the reminiscence bump

    DEFF Research Database (Denmark)

    Thomsen, Dorthe Kirkegaard; Pillemer, David B.; Ivcevic, Zorana

    2011-01-01

    are over-represented at the beginning of chapters. Potential connections between chapters and the cultural life script are also examined. Adult participants first divided their life story into chapters and identified their most positive and most negative chapter. They then recalled a specific memory from......Theories of autobiographical memory posit that extended time periods (here termed chapters) and memories are organised hierarchically. If chapters organise memories and guide their recall, then chapters and memories should show similar temporal distributions over the life course. Previous research...... demonstrates that positive but not negative memories show a reminiscence bump and that memories cluster at the beginning of extended time periods. The current study tested the hypotheses that (1) ages marking the beginning of positive but not negative chapters produce a bump, and that (2) specific memories...

  5. Linear growth of streaming instability in pressure bumps

    Science.gov (United States)

    Auffinger, Jérémy; Laibe, Guillaume

    2018-01-01

    Streaming instability is a powerful mechanism which concentrates dust grains in protoplanetary discs, eventually up to the stage where they collapse gravitationally and form planetesimals. Previous studies inferred that it should be ineffective in viscous discs, too efficient in inviscid discs and may not operate in local pressure maxima where solids accumulate. From a linear analysis of stability, we show that streaming instability behaves differently inside local pressure maxima. Under the action of the strong differential advection imposed by the bump, a novel unstable mode develops and grows even when gas viscosity is large. Hence, pressure bumps are found to be the only places where streaming instability occurs in viscous discs. This offers a promising way to conciliate models of planet formation with recent observations of young discs.

  6. The first bump-bonded pixel detectors on CVD diamond

    CERN Document Server

    Adam, W; Berdermann, E; Bergonzo, P; Bogani, F; Borchi, E; Brambilla, A; Bruzzi, Mara; Colledani, C; Conway, J; Dabrowski, W; Delpierre, P A; Deneuville, A; Dulinski, W; van Eijk, B; Fallou, A; Fizzotti, F; Foulon, F; Fried, M; Gan, K K; Gheeraert, E; Grigoriev, E; Hallewell, G D; Hall-Wilton, R; Han, S; Hartjes, F G; Hrubec, Josef; Husson, D; Kagan, H; Kania, D R; Kaplon, J; Karl, C; Kass, R; Krammer, Manfred; Lo Giudice, A; Lü, R; Manfredi, P F; Manfredotti, C; Marshall, R D; Meier, D; Mishina, M; Oh, A; Palmieri, V G; Pan, L S; Peitz, A; Pernicka, Manfred; Pirollo, S; Polesello, P; Pretzl, Klaus P; Re, V; Riester, J L; Roe, S; Roff, D G; Rudge, A; Schnetzer, S R; Sciortino, S; Speziali, V; Stelzer, H; Steuerer, J; Stone, R; Tapper, R J; Tesarek, R J; Trawick, M L; Trischuk, W; Turchetta, R; Vittone, E; Wagner, A; Walsh, A M; Wedenig, R; Weilhammer, Peter; Zeuner, W; Ziock, H J; Zöller, M; Charles, E; Ciocio, A; Dao, K; Einsweiler, Kevin F; Fasching, D; Gilchriese, M G D; Joshi, A; Kleinfelder, S A; Milgrome, O; Palaio, N; Richardson, J; Sinervo, P K; Zizka, G

    1999-01-01

    Diamond is a nearly ideal material for detecting ionising radiation. Its outstanding radiation hardness, fast charge collection and low leakage current allow it to be used in high radiation environments. These characteristics make diamond sensors particularly appealing for use in the next generation of pixel detectors. Over the last year, the RD42 collaboration has worked with several groups that have developed pixel readout electronics in order to optimise diamond sensors for bump-bonding. This effort resulted in an operational diamond pixel sensor that was tested in a pion beam. We demonstrate that greater than 98565544f the channels were successfully bump-bonded and functioning. The device shows good overall hit efficiency as well as clear spatial hit correlation to tracks measured in a silicon reference telescope. A position resolution of 14.8 mu m was observed, consistent with expectations given the detector pitch. (13 refs).

  7. Injection Bump Synchronization Study for the CERN PS

    CERN Document Server

    Serluca, Maurizio; Gilardoni, Simone; CERN. Geneva. ATS Department

    2016-01-01

    In the framework of the LHC Injector Upgrade (LIU) project the CERN PS injection kinetic energy will be upgraded from 1.4 to 2 GeV. The present injection bump is made by four bumpers in Straight Section (SS) 40, 42, 43, 44 and it will be converted in a five bumpers system to allow additional flexibility in the bump shape with a reduction of the proton losses during the bump closure. The injection section SS42 has being redesigned to accommodate a new eddy current septum which will host a new bumper magnet in the same vacuum vessel due to reduced longitudinal space availability. The synchronization and amplitude variation of the power converter of the in-vacuum bumper 42 with respect to the remaining outside vacuum bumpers 40, 41, 43, 44 can lead to orbit distortion and consequent losses during injection. In this note we present the experimental results from Machine Development (MD) studies along with simulations for the present system at 1.4 GeV to quantify the acceptable orbit distortion and the performance ...

  8. The peaks of life: The differential temporal locations of the reminiscence bump across disparate cueing methods

    DEFF Research Database (Denmark)

    Koppel, Jonathan Mark; Berntsen, Dorthe

    2015-01-01

    The reminiscence bump has generally been assessed through either (1) the cue word method, or (2) several related methods which we refer to under the umbrella of the important memories method. Here we provide a review of the literature demonstrating that the temporal location of the bump varies...... systematically according to cueing method, with the mean range of the bump located from 8.7 to 22.5 years of age for word-cued memories, versus 15.1 to 27.9 for important memories. This finding has hitherto been under-acknowledged, as existing theoretical accounts of the bump generally hold its location...... to be stable across cueing methods. We therefore re-evaluate existing theoretical accounts of the bump in light of these varying locations, addressing each account’s consistency with (1) the respective bumps found through each method taken individually, and (2) the sensitivity of the bump’s location to cueing...

  9. Elastic energy of curvature-driven bump formation on red blood cell membrane.

    OpenAIRE

    Waugh, R.E.

    1996-01-01

    Model calculations were performed to explore quantitative aspects of the discocyte-echinocyte shape transformation in red blood cells. The shape transformation was assumed to be driven by changes in the preferred curvature of the membrane bilayer and opposed by the elastic shear rigidity of the membrane skeleton. The energy required for echinocyte bump formation was calculated for a range of bump shapes for different preferred curvatures. Energy minima corresponding to nonzero bump heights we...

  10. Analysis of Power Generating Speed Bumps Made of Concrete Foam Composite

    Science.gov (United States)

    Syam, B.; Muttaqin, M.; Hastrino, D.; Sebayang, A.; Basuki, W. S.; Sabri, M.; Abda, S.

    2017-03-01

    This paper discusses the analysis of speed bump made of concrete foam composite which is used to generate electrical power. Speed bumps are designed to decelerate the speed of vehicles before passing through toll gates, public areas, or any other safety purposes. In Indonesia a speed bump should be designed in the accordance with KM Menhub 3 year 1994. In this research, the speed bump was manufactured with dimensions and geometry comply to the regulation mentioned above. Concrete foam composite speed bumps were used due to its light weight and relatively strong to receive vertical forces from the tyres of vehicles passing over the bumps. The reinforcement materials are processed from empty fruit bunch of oil palm. The materials were subjected to various tests to obtain its physical and mechanical properties. To analyze the structure stability of the speed bumps some models were analyzed using a FEM-based numerical softwares. It was obtained that the speed bumps coupled with polymeric composite bar (3 inches in diameter) are significantly reduce the radial stresses. In addition, the speed bumps equipped with polymeric composite casing or steel casing are also suitable for use as part of system components in producing electrical energy.

  11. Effectiveness of Emittance Bumps in the NLC and US Cold LC Main Linear Accelerators (LCC-0138)

    Energy Technology Data Exchange (ETDEWEB)

    Tenenbaum, P

    2004-05-13

    We report on a series of studies on the effectiveness of closed orbit bumps in the linacs of the NLC and the USColdLC. In the first study, emittance dilutions of a pure-wakefield or pure-dispersion character are introduced in each linac, and a set of emittance bumps is tested to determine the most effective bump location in the linac, and the net effectiveness. In the second study, a more realistic set of dilutions are introduced and the wakefield bumps used in the first study are applied.

  12. Intelligent Smartphone based system for detecting speed bumps and reducing car speed

    Directory of Open Access Journals (Sweden)

    Daraghmi Yousef-Awwad

    2016-01-01

    Full Text Available Although speed bumps are used to force drivers reduce car speed for avoiding accidents, these bumps may cause car crash or accident when drivers do not notice them. Studies have proposed different methods to detect bumps and alert drivers. However, these methods have limitations and require modifications to enable accurate detection. Also these methods did not propose speed reduction approaches. Therefore, in this research, we propose a method that utilizes smartphone microelectronic mechanical technology for speed bump detection. The system uses the gravity sensor to detect the vertical vibration of cars passes over bumps and the GPS to determine the position of the bump. To give accurate detection results, data are collected from crowd, stored and processed on the cloud. The system also contains a speed reduction unit which is attached to the brake pedal and reduces the speed if a bump is detected. A small scale experiment showed that the system detected the position and the height of bumps with a very small error. The system also reduced the speed of cars at the moment they hit the bumps to a point that does not cause any harm to cars or passengers.

  13. Local sparse bump hunting reveals molecular heterogeneity of colon tumors.

    Science.gov (United States)

    Dazard, Jean-Eudes; Rao, J Sunil; Markowitz, Sanford

    2012-05-20

    The question of molecular heterogeneity and of tumoral phenotype in cancer remains unresolved. To understand the underlying molecular basis of this phenomenon, we analyzed genome-wide expression data of colon cancer metastasis samples, as these tumors are the most advanced and hence would be anticipated to be the most likely heterogeneous group of tumors, potentially exhibiting the maximum amount of genetic heterogeneity. Casting a statistical net around such a complex problem proves difficult because of the high dimensionality and multicollinearity of the gene expression space, combined with the fact that genes act in concert with one another and that not all genes surveyed might be involved. We devise a strategy to identify distinct subgroups of samples and determine the genetic/molecular signature that defines them. This involves use of the local sparse bump hunting algorithm, which provides a much more optimal and biologically faithful transformed space within which to search for bumps. In addition, thanks to the variable selection feature of the algorithm, we derived a novel sparse gene expression signature, which appears to divide all colon cancer patients into two populations: a population whose expression pattern can be molecularly encompassed within the bump and an outlier population that cannot be. Although all patients within any given stage of the disease, including the metastatic group, appear clinically homogeneous, our procedure revealed two subgroups in each stage with distinct genetic/molecular profiles. We also discuss implications of such a finding in terms of early detection, diagnosis and prognosis. Copyright © 2011 John Wiley & Sons, Ltd.

  14. Aqueous-based thick photoresist removal for bumping applications

    Science.gov (United States)

    Moore, John C.; Brewer, Alex J.; Law, Alman; Pettit, Jared M.

    2015-03-01

    Cleaning processes account for over 25% of processing in microelectronic manufacturing [1], suggesting electronics to be one of the most chemical intensive markets in commerce. Industry roadmaps exist to reduce chemical exposure, usage, and waste [2]. Companies are encouraged to create a safer working environment, or green factory, and ultimately become certified similar to LEED in the building industry [3]. A significant step in this direction is the integration of aqueous-based photoresist (PR) strippers which eliminate regulatory risks and cut costs by over 50%. One of the largest organic solvent usages is based upon thick PR removal during bumping processes [4-6]. Using market projections and the benefits of recycling, it is estimated that over 1,000 metric tons (mt) of residuals originating from bumping processes are incinerated or sent to a landfill. Aqueous-based stripping would eliminate this disposal while also reducing the daily risks to workers and added permitting costs. Positive-tone PR dissolves in aqueous strippers while negative-tone systems are lifted-off from the substrate, bumps, pillars, and redistribution layers (RDL). While the wafers are further processed and rinsed, the lifted-off PR is pumped from the tank, collected onto a filter, and periodically back-flushed to the trash. The PR solids become a non-hazardous plastic waste while the liquids are mixed with the developer stream, neutralized, filtered, and in most cases, disposed to the sewer. Regardless of PR thickness, removal processes may be tuned to perform in <15min, performing at rates nearly 10X faster than solvents with higher bath lives. A balanced formula is safe for metals, dielectrics, and may be customized to any fab.

  15. Bumps in the journey toward a new care delivery model.

    Science.gov (United States)

    Shendell-Falik, Nancy; Ide, Patricia; Mohr, Bernard J; Laliberte, Robert A; de Guerre, Donald W

    2012-01-01

    On a journey to the future, an initial strategy of engagement and design is essential but inevitably inadequate. Instead, as bumps in the road emerge, the ability of leadership to regroup and refocus is the key. This is the story of one such journey-a journey pursuing the triple aim of excellence in patient care, patient and staff satisfaction, and economic sustainability. It is one chapter in the transformation of an 1800-employee patient care services organization. It is not the first chapter nor will it be the last.

  16. Chorionic bump on first-trimester sonography: not necessarily a poor prognostic indicator for pregnancy.

    Science.gov (United States)

    Arleo, Elizabeth Kagan; Troiano, Robert N

    2015-01-01

    The purpose of this study was to determine the live birth rate of pregnancies with a diagnosis of a chorionic bump, a convex bulge from the choriodecidual surface into the first-trimester gestational sac. Pregnant patients at least 18 years old with the finding of a chorionic bump on first-trimester sonography were included in this prospective observational study. The independent variables were chorionic bump size and number and presence or absence of a history of infertility or coagulation disorder. The primary end point was pregnancy outcome. During the 4-year study period, 52 pregnancies had a diagnosis of a chorionic bump. Overall, 34 resulted in live births, corresponding to an absolute live birth rate of 65%, and 18 were nonviable. Forty-one chorionic bump pregnancies were otherwise normal (ie, pregnancies in which a gestational sac, yolk sac, and embryo with heartbeat were seen at some point), and in this subset, the live birth rate was 83% (34 of 41). All pregnancies with more than 1 chorionic bump (4) ended in demise (100%). The average maximum dimension of the chorionic bump was 1.3 cm (range, 0.5-3.8 cm); however there was not a statistically significant correlation between chorionic bump size and pregnancy outcome (P = .5866; odds ratio, 0.54; 95% confidence interval, 0.06-5.01). Nine patients (17%) had a history of infertility treatment, and 4 (8%) had a history of coagulation disorder. Only 1 chorionic bump pregnancy was associated with a birth defect. The live birth rate in our chorionic bump cohort was 65% overall and even higher (83%) if the pregnancy was otherwise normal. The clinical implication is that a chorionic bump on first-trimester sonography is not necessarily associated with a guarded prognosis. © 2015 by the American Institute of Ultrasound in Medicine.

  17. EXTRACTING PRECISE AND AFFORDABLE DEMS DESPITE OF THE CLOUDS. AJAX: THE JOINING OF RADAR AND OPTICAL STRENGTHS

    Directory of Open Access Journals (Sweden)

    1 L. Cunin

    2012-07-01

    The DEMs extracted from TerraSAR-X and HRS proved extremely consistent with each other, showing a mean difference of 0.80m. This allows to propose a unified Elevation30 product to the users, with a guaranteed accuracy materialized into the product through a dedicated vertical Accuracy Commitment Mask.

  18. Experimental and modeling study of the flow over a skewed bump

    Science.gov (United States)

    Ching, David S.; Elkins, Christopher J.; Eaton, John K.

    2016-11-01

    Three-dimensional separated flows can be very sensitive to geometry and inlet conditions, such that a small change in the geometry or the upstream boundary layer could cause the flow structure to change drastically. This study examines the geometric sensitivity of a skewed bump with axis ratio 4/3 by changing the angle of the bump with respect to the flow. The three-dimensional, three-component mean velocity field was acquired using Magnetic Resonance Velocimetry (MRV) for several bump angles. The flow is dominated by large coherent vortices in the wake. For a symmetric case, two counter-rotating vortices exist in the wake, but when the bump is skewed relative to the oncoming flow one vortex structure is much stronger and overwhelms the other vortex. A comparison to RANS simulations found that the RANS simulations predict the velocity fields with reasonable accuracy within the separation bubble, but are very inaccurate downstream of reattachment. Using a time-resolved MRV sequence, the shedding frequency of the wake was determined for two bump angles. Hot-wire anemometry confirmed the shedding frequencies found from the MRV data and observed that the shedding frequency is sensitive to the bump angle at low bump angles, but is insensitive at high bump angles. Funding provided by the Office of Naval Research.

  19. Shrinking of bumps by drawing scintillating fibres through a hot conical tool

    CERN Document Server

    Rodrigues Cavalcante, Ana Barbara; Gavardi, Laura; Joram, Christian; Kristic, Robert; Pierschel, Gerhard; Schneider, Thomas

    2016-01-01

    The LHCb SciFi tracker will be based on scintillating fibres with a nominal diameter of 250 $\\mu$m. A small length fraction of these fibres shows millimetre-scale fluctuations of the diameter, also known as bumps and necks. In particular, bumps exceeding a diameter of about 350 $\\mu$m are problematic as they can distort the winding pattern of the fibre mats over more extended regions. We present a method to reduce the diameter of large bumps to a diameter of 350 $\\mu$m by locally heating and pulling the fibre through a conical tool. The method has been proven to work for bumps up to 450 – 500 $\\mu$m diameter. Larger bumps need to be treated manually by a cut-and-glue technique which relies on UV-curing instant glue. The bump shrinking and cut-and-glue processes were integrated in a fibre diameter scanner at CERN. The central scanning and bump shrinking of all fibres is expected to minimise bump related issues at the four mat winding centres of the SciFi project.

  20. A precise extraction of the induced polarization in the 4He(e,e'p)3H reaction

    Energy Technology Data Exchange (ETDEWEB)

    S.P. Malace, M. Paolone, S. Strauch

    2011-01-01

    We measured with unprecedented precision the induced polarization Py in 4He(e,e'p)3H at Q^2 = 0.8 (GeV/c)^2 and 1.3 (GeV/c)^2. The induced polarization is indicative of reaction-mechanism effects beyond the impulse approximation. Our results are in agreement with a relativistic distorted-wave impulse approximation calculation but are over-estimated by a calculation with strong charge-exchange effects. Our data are used to constrain the strength of the spin independent charge-exchange term in the latter calculation.

  1. Intermetallic Compound Growth and Reliability of Cu Pillar Bumps Under Current Stressing

    Science.gov (United States)

    Kim, Byoung-Joon; Lim, Gi-Tae; Kim, Jaedong; Lee, Kiwook; Park, Young-Bae; Lee, Ho-Young; Joo, Young-Chang

    2010-10-01

    Fine-pitch Cu pillar bumps have been adopted for flip-chip bonding technology. Intermetallic compound (IMC) growth in Cu pillar bumps was investigated as a function of annealing or current stressing by in situ observation. The effect of IMC growth on the mechanical reliability of the Cu pillar bumps was also investigated. It is noteworthy that Sn exhaustion was observed after 240 h of annealing when current stressing was not applied, and IMC growth rates were changed remarkably. As the applied current densities increased, the time required for complete Sn consumption became shorter. In addition, Kirkendall voids, which would be detrimental to the mechanical reliability of Cu pillar bumps, were observed in both Cu3Sn/Cu pillars and Cu3Sn/Cu under-bump metallization interfaces. Die shear force was measured for Cu pillar samples prepared with various annealing times, and degradation of mechanical strength was observed.

  2. Study on defective elements from indium bump preparation in focal plane array fabrication

    Science.gov (United States)

    Hou, Zhijin; Fu, Li; Si, Junjie; Wang, Wei; Lv, Yanqiu; Lu, Zhengxiong; Wang, Jinchun

    2016-10-01

    The defective elements from indium bump preparation in FPA fabrication are tested by optical microscopy and FPA testing bench. Results show that the defective elements from indium bump fabrication include connecting defective elements and missing defective elements. It is easy to identify missing defective elements by FPA testing bench because the response voltage of defective elements is zero and response voltage of other elements around defective element is higher than that of normal elements. And it is difficult to identify connecting defective elements by FPA testing bench because the response voltage of connecting defective elements is basically the same as that of normal elements. The defective elements from indium bump fabrication are due to the indium bump with connecting or missing caused by the process of photolithography, eroding and lift-off. Fabrication process such as photolithography, eroding and lift-off is optimized to reduce defective elements from indium bump fabrication.

  3. Bumps, witches and bouncing beams: lab investigations of internal waves

    Science.gov (United States)

    Peacock, Thomas; Balmforth, Neil; Tabaei, Ali

    2005-11-01

    There is a great, ongoing effort to better understand the processes surrounding internal wave generation, propagation and dissipation in the oceans. To contribute to this effort, we are in the process of establishing a state-of-the-art experimental facility. The facility, based around the digital schlieren method, is designed to investigate both linear and non-linear phenomena in a laboratory setting. We here report the latest experimental results concerning tidal conversion by typical topographic features, such as a Gaussian bump and a knife-edge. The quantitative results compare very well with theoretical predictions developed from the classic work of Bell and Hurley, and more recent analysis of subcritical topography by Balmforth et al. In addition, we present more details on recently published results concerning the nonlinear generation of second-harmonic wavebeams at reflecting boundaries.

  4. Precise determination of the deuteron spin structure at low to moderate Q2 with CLAS and extraction of the neutron contribution

    Science.gov (United States)

    Guler, N.; Fersch, R. G.; Kuhn, S. E.; Bosted, P.; Griffioen, K. A.; Keith, C.; Minehart, R.; Prok, Y.; Adhikari, K. P.; Adikaram, D.; Amaryan, M. J.; Anderson, M. D.; Anefalos Pereira, S.; Avakian, H.; Ball, J.; Battaglieri, M.; Batourine, V.; Bedlinskiy, I.; Biselli, A.; Briscoe, W. J.; Brooks, W. K.; Bültmann, S.; Burkert, V. D.; Carman, D. S.; Celentano, A.; Chandavar, S.; Charles, G.; Colaneri, L.; Cole, P. L.; Contalbrigo, M.; Crabb, D.; Crede, V.; D'Angelo, A.; Dashyan, N.; Deur, A.; Djalali, C.; Dodge, G. E.; Dupre, R.; Alaoui, A. El; El Fassi, L.; Elouadrhiri, L.; Eugenio, P.; Fedotov, G.; Fegan, S.; Filippi, A.; Fleming, J. A.; Forest, T. A.; Garillon, B.; Garçon, M.; Gevorgyan, N.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Goetz, J. T.; Golovatch, E.; Gothe, R. W.; Guidal, M.; Guo, L.; Hafidi, K.; Hakobyan, H.; Harrison, N.; Hattawy, M.; Hicks, K.; Ho, D.; Holtrop, M.; Hughes, S. M.; Hyde, C. E.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jo, H. S.; Joo, K.; Joosten, S.; Keller, D.; Khandaker, M.; Kim, A.; Kim, W.; Klein, A.; Klein, F. J.; Kubarovsky, V.; Kuleshov, S. V.; Livingston, K.; Lu, H. Y.; Mayer, M.; MacGregor, I. J. D.; McKinnon, B.; Mirazita, M.; Mokeev, V.; Montgomery, R. A.; Movsisyan, A.; Munoz Camacho, C.; Nadel-Turonski, P.; Net, L. A.; Niculescu, I.; Osipenko, M.; Ostrovidov, A. I.; Park, K.; Pasyuk, E.; Pisano, S.; Pogorelko, O.; Price, J. W.; Procureur, S.; Ripani, M.; Rizzo, A.; Rosner, G.; Rossi, P.; Roy, P.; Sabatié, F.; Salgado, C.; Schott, D.; Schumacher, R. A.; Seder, E.; Simonyan, A.; Skorodumina, Iu.; Sokhan, D.; Sparveris, N.; Strakovsky, I. I.; Strauch, S.; Sytnik, V.; Tian, Ye; Tkachenko, S.; Ungaro, M.; Voutier, E.; Walford, N. K.; Wei, X.; Weinstein, L. B.; Wood, M. H.; Zachariou, N.; Zana, L.; Zhang, J.; Zhao, Z. W.; Zonta, I.; CLAS Collaboration

    2015-11-01

    We present the final results for the deuteron spin structure functions obtained from the full data set collected in 2000-2001 with Jefferson Lab's continuous electron beam accelerator facility (CEBAF) using the CEBAF large acceptance spectrometer (CLAS). Polarized electrons with energies of 1.6, 2.5, 4.2, and 5.8 GeV were scattered from deuteron (15ND3 ) targets, dynamically polarized along the beam direction, and detected with CLAS. From the measured double-spin asymmetry, the virtual photon absorption asymmetry A1d and the polarized structure function g1d were extracted over a wide kinematic range (0.05 GeV2extract from these data the polarized structure functions A1n and g1n of the (bound) neutron, which are so far unknown in the resonance region, W <2 GeV. We compare our final results, including several moments of the deuteron and neutron spin structure functions, with various theoretical models and expectations, as well as parametrizations of the world data. The unprecedented precision and dense kinematic coverage of these data can aid in future extractions of polarized parton distributions, tests of perturbative QCD predictions for the quark polarization at large x , a better understanding of quark-hadron duality, and more precise values for higher-twist matrix elements in the framework of the operator product expansion.

  5. Defects inspection of the solder bumps using self reference technology in active thermography

    Science.gov (United States)

    Lu, Xiangning; Shi, Tielin; Han, Jiguang; Liao, Guanglan; Su, Lei; Wang, Suya

    2014-03-01

    With the decrease of solder bumps in dimension and pitch, defects inspection of the solder bumps become more difficult. A nondestructive detection system based on the active thermography has been developed for solder bumps inspection. However, heating non-uniformities and emissivity differences may impede the defects recognition. In this paper, we propose a method using a self reference technology based on a source distribution image (SDI) to eliminate the influence of unevenness in emissivity values and heating power distribution. Three thermograms captured right after the heat pulse are averaged to create the SDI. Then the SDI is subtracted from the original thermograms, and we get the thermal contrast images, in which eight points on the edge of each hot spot are selected as the feature points for the corresponding bump. Thermal difference between the feature points and the central point are adopted to quantify the thermal behaviors of the solder bumps, by which the missing bump is distinguished from the reference bumps. The results show that it is effective using the method to eliminate the impacts of emissivity unevenness and heating non-uniformities on defects identification in the active infrared test.

  6. Precision manufacturing

    CERN Document Server

    Dornfeld, David

    2008-01-01

    Today there is a high demand for high-precision products. The manufacturing processes are now highly sophisticated and derive from a specialized genre called precision engineering. Precision Manufacturing provides an introduction to precision engineering and manufacturing with an emphasis on the design and performance of precision machines and machine tools, metrology, tooling elements, machine structures, sources of error, precision machining processes and precision process planning. As well as discussing the critical role precision machine design for manufacturing has had in technological developments over the last few hundred years. In addition, the influence of sustainable manufacturing requirements in precision processes is introduced. Drawing upon years of practical experience and using numerous examples and illustrative applications, David Dornfeld and Dae-Eun Lee cover precision manufacturing as it applies to: The importance of measurement and metrology in the context of Precision Manufacturing. Th...

  7. Ship Sensor Observations for Investigating the Charleston Bump 2003 - Office of Ocean Exploration

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hourly measurements made by selected ship sensors on the R/V Seward Johnson during the "Investigating the Charleston Bump 2003" expedition sponsored by the National...

  8. Indium bump array fabrication on small CMOS circuit for flip-chip bonding

    Institute of Scientific and Technical Information of China (English)

    Huang Yuyang; Zhang Yuxiang; Yin Zhizhen; Cui Guoxin; Liu H C; Bian Lifeng; Yang Hui; Zhang Yaohui

    2011-01-01

    We demonstrate a novel method for indium bump fabrication on a small CMOS circuit chip that is to be flip-chip bonded with a GaAs/AlGaAs multiple quantum well spatial light modulator.A chip holder with a via hole is used to coat the photoresist for indium bump lift-off.The 1000 μm-wide photoresist edge bead around the circuit chip can be reduced to less than 500μm,which ensures the integrity of the indium bump array.64 × 64 indium arrays with 20 μm-high,30 μm-diameter bumps are successfully formed on a 5 × 6.5 mm2 CMOS chip.

  9. Ship Track for Investigating the Charleston Bump 2003 - Office of Ocean Exploration

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Ship track of the R/V Seward Johnson during the "Investigating the Charleston Bump 2003" expedition sponsored by the National Oceanic and Atmospheric Administration...

  10. The study of selective heating of indium bump in MCT infrared focal plane array

    Science.gov (United States)

    Zhang, Haiyan; Cao, Lan; Zhuang, Fulong; Hu, Xiaoning; Gong, Haimei

    2012-10-01

    Generally the electrical interconnectivity between The Mercury Cadmium Telluride (MCT) infrared focal plane array (IRFPA) device and circuit takes the flip chip technology using indium bump as a connection medium. In order to improve the reliability of the interconnectivity indium melting is a common packaging technique at present. This technique is called reflow soldering. The heating is transferred to the indium bump by heating the device and circuit. This heating process will persist about 10 minutes resulting in the MCT material going through a 10 minutes high temperature baking course. This baking process will strongly degenerate the characteristic of the MCT device. Under this circumstance this article gives a new heating technique for indium bump which is call induction heating melting technique. This method realizes the selective heating. While the indium bump is melted by the conduction heating the semiconductor material such as MCT can't be heated.

  11. Two-Dimensional Bumps in Piecewise Smooth Neural Fields with Synaptic Depression

    KAUST Repository

    Bressloff, Paul C.

    2011-01-01

    We analyze radially symmetric bumps in a two-dimensional piecewise-smooth neural field model with synaptic depression. The continuum dynamics is described in terms of a nonlocal integrodifferential equation, in which the integral kernel represents the spatial distribution of synaptic weights between populations of neurons whose mean firing rate is taken to be a Heaviside function of local activity. Synaptic depression dynamically reduces the strength of synaptic weights in response to increases in activity. We show that in the case of a Mexican hat weight distribution, sufficiently strong synaptic depression can destabilize a stationary bump solution that would be stable in the absence of depression. Numerically it is found that the resulting instability leads to the formation of a traveling spot. The local stability of a bump is determined by solutions to a system of pseudolinear equations that take into account the sign of perturbations around the circular bump boundary. © 2011 Society for Industrial and Applied Mathematics.

  12. Franz Joseph Gall and music: the faculty and the bump.

    Science.gov (United States)

    Eling, Paul; Finger, Stanley; Whitaker, Harry

    2015-01-01

    The traditional story maintains that Franz Joseph Gall's (1758-1828) scientific program began with his observations of schoolmates with bulging eyes and good verbal memories. But his search to understand human nature, in particular individual differences in capacities, passions, and tendencies, can also be traced to other important observations, one being of a young girl with an exceptional talent for music. Rejecting contemporary notions of cognition, Gall concluded that behavior results from the interaction of a limited set of basic faculties, each with its own processes for perception and memory, each with its own territory in both cerebral or cerebellar cortices. Gall identified 27 faculties, one being the sense of tone relations or music. The description of the latter is identical in both his Anatomie et Physiologie and Sur les Fonctions du Cerveau et sur Celles de Chacune de ses Parties, where he provided positive and negative evidences and discussed findings from humans and lower animals, for the faculty. The localization of the cortical faculty for talented musicians, he explained, is demonstrated by a "bump" on each side of the skull just above the angle of the eye; hence, the lower forehead of musicians is broader or squarer than in other individuals. Additionally, differences between singing and nonsinging birds also correlate with cranial features. Gall even brought age, racial, and national differences into the picture. What he wrote about music reveals much about his science and creative thinking. © 2015 Elsevier B.V. All rights reserved.

  13. Stability of bumps in piecewise smooth neural fields with nonlinear adaptation

    KAUST Repository

    Kilpatrick, Zachary P.

    2010-06-01

    We study the linear stability of stationary bumps in piecewise smooth neural fields with local negative feedback in the form of synaptic depression or spike frequency adaptation. The continuum dynamics is described in terms of a nonlocal integrodifferential equation, in which the integral kernel represents the spatial distribution of synaptic weights between populations of neurons whose mean firing rate is taken to be a Heaviside function of local activity. Discontinuities in the adaptation variable associated with a bump solution means that bump stability cannot be analyzed by constructing the Evans function for a network with a sigmoidal gain function and then taking the high-gain limit. In the case of synaptic depression, we show that linear stability can be formulated in terms of solutions to a system of pseudo-linear equations. We thus establish that sufficiently strong synaptic depression can destabilize a bump that is stable in the absence of depression. These instabilities are dominated by shift perturbations that evolve into traveling pulses. In the case of spike frequency adaptation, we show that for a wide class of perturbations the activity and adaptation variables decouple in the linear regime, thus allowing us to explicitly determine stability in terms of the spectrum of a smooth linear operator. We find that bumps are always unstable with respect to this class of perturbations, and destabilization of a bump can result in either a traveling pulse or a spatially localized breather. © 2010 Elsevier B.V. All rights reserved.

  14. Two bump solutions of a homogenized Wilson-Cowan model with periodic microstructure

    Science.gov (United States)

    Malyutina, Elena; Wyller, John; Ponosov, Arcady

    2014-03-01

    We study the existence and stability of 2-bump solutions of the one-population homogenized Wilson-Cowan model, where the heterogeneity is built in the connectivity functions by assuming periodic modulations in both the synaptic footprint and in the spatial scale. The existence analysis reveals that the generic picture consists of two bumps states for each admissible threshold value for the case when the solutions are independent of the local variable and the firing rate function is modeled as a Heaviside function. A framework for analyzing the stability of 2-bumps is formulated, based on spectral theory for Fredholm integral operators. The stability method deforms to the standard Evans function approach for the translationally invariant case in the limit of no heterogeneity, in a way analogous to the single bump case for the homogenized model. The numerical study of the stability problem reveals that both the broad and narrow bumps are unstable just as in the translationally invariant case when the connectivity function is modeled by means of a wizard hat function. For the damped oscillating connectivity kernel, we give a concrete example of a 2-bump solution which is stable for all admissible values of the heterogeneity parameter.

  15. Precision Machining

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    This special issue of S¯adhan¯a is devoted to Precision Engineering. Recent progress in this field clearly indicates the transition of precision technology to precision science. Dr. Mer- chant's new theory on the mechanics of metal cutting in 1944 heralded a new approach, moving away from the empirical work of Taylor ...

  16. Development of an Indium bump bond process for silicon pixel detectors at PSI

    Energy Technology Data Exchange (ETDEWEB)

    Broennimann, Ch. [Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); Glaus, F. [Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); Gobrecht, J. [Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); Heising, S. [Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); Horisberger, M. [Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); Horisberger, R. [Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); Kaestli, H.C. [Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); Lehmann, J. [Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); Rohe, T. [Paul Scherrer Institut, 5232 Villigen PSI (Switzerland)]. E-mail: Tilman.Rohe@psi.ch; Streuli, S. [ETH Zuerich, IPP, 5232 Villigen PSI (Switzerland)

    2006-09-01

    The hybrid pixel detectors used in the high-energy physics experiments currently under construction use a vertical connection technique, the so-called bump bonding. As the pitch below 100{mu}m, required in these applications, cannot be fulfilled with standard industrial processes (e.g. the IBM C4 process), an in-house bump bond process using reflowed indium bumps was developed at PSI as part of the R and D for the CMS-pixel detector. The bump deposition on the sensor is performed in two subsequent lift-off steps. As the first photolithographic step a thin under bump metalization (UBM) is sputtered onto bump pads. It is wettable by indium and defines the diameter of the bump. The indium is evaporated via a second photolithographic step with larger openings and is reflowed afterwards. The height of the balls is defined by the volume of the indium. On the readout chip only one photolithographic step is carried out to deposit the UBM and a thin indium layer for better adhesion. After mating both parts a second reflow is performed for self-alignment and obtaining high mechanical strength. For the placement of the chips a manual and an automatic machine were constructed. The former is very flexible in handling different chip and module geometries but has a limited throughput while the latter features a much higher grade of automatization and is therefore much more suited for producing hundreds of modules with a well-defined geometry. The reliability of this process was proven by the successful construction of the PILATUS detector. The construction of PILATUS 6M (60 modules) and the CMS pixel barrel (roughly 800 modules) has started in early 2006.

  17. Application of robust color composite fringe in flip-chip solder bump 3-D measurement

    Science.gov (United States)

    Kuo, Chung-Feng Jeffrey; Wu, Han-Cheng

    2017-04-01

    This study developed a 3-D measurement system based on flip-chip solder bump, used fringes with different modulation intensities in color channels, in order to produce color composite fringe with robustness, and proposed a multi-channel composite phase unwrapping algorithm, which uses fringe modulation weights of different channels to recombine the phase information for better measurement accuracy and stability. The experimental results showed that the average measurement accuracy is 0.43μm and the standard deviation is 1.38 μm. The results thus proved that the proposed 3-D measurement system is effective in measuring a plane with a height of 50 μm. In the flip-chip solder bump measuring experiment, different fringe modulation configurations were tested to overcome the problem of reflective coefficient between the flip-chip base board and the solder bump. The proposed system has a good measurement results and robust stability in the solder bump measurement, and can be used for the measurement of 3-D information for micron flip-chip solder bump application.

  18. Investigation of Sn-Pb solder bumps of prototype photo detectors for the LHCb experiment

    CERN Document Server

    Delsante, M L; Arnau-Izquierdo, G

    2004-01-01

    The Large Hadron Collider (LHC) is now under construction at the European Organization for Nuclear Research (CERN). LHCb is one of the dedicated LHC experiments, allowing high energy proton-proton collisions to be exploited. This paper presents the results of the metallurgic studies carried out on Sn-Pb solder bumps of prototype vacuum photo detectors under development for LHCb, and in particular for the ring imaging Cherenkov-hybrid photo diode (RICH-HPD) project. These detectors encapsulate, in a vacuum tube, an assembly made of two silicon chips bonded together by a matrix of solder bumps. Each bump lies on a suitable system of under-bump metallic layers ensuring mechanical and electrical transition between the chip pad and the solder alloy. During manufacturing of the detector, bump-bonded (BB) assemblies are exposed to severe heat cycles up to 400 degree C inducing, in the present fabrication process, a clear degradation of electrical connectivity. Several investigations such as microstructural observati...

  19. On the Application of Contour Bumps for Transonic Drag Reduction(Invited)

    Science.gov (United States)

    Milholen, William E., II; Owens, Lewis R.

    2005-01-01

    The effect of discrete contour bumps on reducing the transonic drag at off-design conditions on an airfoil have been examined. The research focused on fully-turbulent flow conditions, at a realistic flight chord Reynolds number of 30 million. State-of-the-art computational fluid dynamics methods were used to design a new baseline airfoil, and a family of fixed contour bumps. The new configurations were experimentally evaluated in the 0.3-m Transonic Cryogenic Tunnel at the NASA Langley Research center, which utilizes an adaptive wall test section to minimize wall interference. The computational study showed that transonic drag reduction, on the order of 12% - 15%, was possible using a surface contour bump to spread a normal shock wave. The computational study also indicated that the divergence drag Mach number was increased for the contour bump applications. Preliminary analysis of the experimental data showed a similar contour bump effect, but this data needed to be further analyzed for residual wall interference corrections.

  20. Dynamic traversal of high bumps and large gaps by a small legged robot

    Science.gov (United States)

    Gart, Sean; Winey, Nastasia; de La Tijera Obert, Rafael; Li, Chen

    Small animals encounter and negotiate diverse obstacles comparable in size or larger than themselves. In recent experiments, we found that cockroaches can dynamically traverse bumps up to 4 times hip height and gaps up to 1 body length. To better understand the physics that governs these locomotor transitions, we studied a small six-legged robot negotiating high bumps and large gaps and compared it to animal observations. We found that the robot was able to traverse bumps as large as 1 hip height and gaps as wide as 0.5 body length. For the bump, the robot often climbed over to traverse when initial body yaw was small, but was often deflected laterally and failed to traverse when initial body yaw was large. A simple locomotion energy landscape model explained these observations. For the gap, traversal probability decreased with gap width, which was well explained by a simple Lagrangian model of a forward-moving rigid body falling over the gap edge. For both the bump and the gap, animal performance far exceeded that of the robot, likely due to their relatively higher running speeds and larger rotational oscillations prior to and during obstacle traversal. Differences between animal and robot obstacle negotiation behaviors revealed that animals used active strategies to overcome potential energy barriers.

  1. Low-cost bump-bonding processes for high energy physics pixel detectors

    CERN Document Server

    AUTHOR|(CDS)2069357; Blank, Thomas; Colombo, Fabio; Dierlamm, Alexander Hermann; Husemann, Ulrich; Kudella, Simon; Weber, M

    2016-01-01

    In the next generation of collider experiments detectors will be challenged by unprecedented particle fluxes. Thus large detector arrays of highly pixelated detectors with minimal dead area will be required at reasonable costs. Bump-bonding of pixel detectors has been shown to be a major cost-driver. KIT is one of five production centers of the CMS barrel pixel detector for the Phase I Upgrade. In this contribution the SnPb bump-bonding process and the production yield is reported. In parallel to the production of the new CMS pixel detector, several alternatives to the expensive photolithography electroplating/electroless metal deposition technologies are developing. Recent progress and challenges faced in the development of bump-bonding technology based on gold-stud bonding by thin (15 μm) gold wire is presented. This technique allows producing metal bumps with diameters down to 30 μm without using photolithography processes, which are typically required to provide suitable under bump metallization. The sh...

  2. Why precision?

    Energy Technology Data Exchange (ETDEWEB)

    Bluemlein, Johannes

    2012-05-15

    Precision measurements together with exact theoretical calculations have led to steady progress in fundamental physics. A brief survey is given on recent developments and current achievements in the field of perturbative precision calculations in the Standard Model of the Elementary Particles and their application in current high energy collider data analyses.

  3. The effect of dilution and the use of a post-extraction nucleic acid purification column on the accuracy, precision, and inhibition of environmental DNA samples

    Science.gov (United States)

    Mckee, Anna M.; Spear, Stephen F.; Pierson, Todd W.

    2015-01-01

    Isolation of environmental DNA (eDNA) is an increasingly common method for detecting presence and assessing relative abundance of rare or elusive species in aquatic systems via the isolation of DNA from environmental samples and the amplification of species-specific sequences using quantitative PCR (qPCR). Co-extracted substances that inhibit qPCR can lead to inaccurate results and subsequent misinterpretation about a species’ status in the tested system. We tested three treatments (5-fold and 10-fold dilutions, and spin-column purification) for reducing qPCR inhibition from 21 partially and fully inhibited eDNA samples collected from coastal plain wetlands and mountain headwater streams in the southeastern USA. All treatments reduced the concentration of DNA in the samples. However, column purified samples retained the greatest sensitivity. For stream samples, all three treatments effectively reduced qPCR inhibition. However, for wetland samples, the 5-fold dilution was less effective than other treatments. Quantitative PCR results for column purified samples were more precise than the 5-fold and 10-fold dilutions by 2.2× and 3.7×, respectively. Column purified samples consistently underestimated qPCR-based DNA concentrations by approximately 25%, whereas the directional bias in qPCR-based DNA concentration estimates differed between stream and wetland samples for both dilution treatments. While the directional bias of qPCR-based DNA concentration estimates differed among treatments and locations, the magnitude of inaccuracy did not. Our results suggest that 10-fold dilution and column purification effectively reduce qPCR inhibition in mountain headwater stream and coastal plain wetland eDNA samples, and if applied to all samples in a study, column purification may provide the most accurate relative qPCR-based DNA concentrations estimates while retaining the greatest assay sensitivity.

  4. Fluxless flip-chip bonding using a lead-free solder bumping technique

    Science.gov (United States)

    Hansen, K.; Kousar, S.; Pitzl, D.; Arab, S.

    2017-09-01

    With the LHC exceeding the nominal instantaneous luminosity, the current barrel pixel detector (BPIX) of the CMS experiment at CERN will reach its performance limits and undergo significant radiation damage. In order to improve detector performance in high luminosity conditions, the entire BPIX is replaced with an upgraded version containing an additional detection layer. Half of the modules comprising this additional layer are produced at DESY using fluxless and lead-free bumping and bonding techniques. Sequential solder-jetting technique is utilized to wet 40-μm SAC305 solder spheres on the silicon-sensor pads with electroless Ni, Pd and immersion Au (ENEPIG) under-bump metallization (UBM). The bumped sensors are flip-chip assembled with readout chips (ROCs) and then reflowed using a flux-less bonding facility. The challenges for jetting low solder volume have been analyzed and will be presented in this paper. An average speed of 3.4 balls per second is obtained to jet about 67 thousand solder balls on a single chip. On average, 7 modules have been produced per week. The bump-bond quality is evaluated in terms of electrical and mechanical properties. The peak-bump resistance is about 17.5 mΩ. The cross-section study revealed different types of intermetallic compounds (IMC) as a result of interfacial reactions between UBM and solder material. The effect of crystalline phases on the mechanical properties of the joint is discussed. The mean shear strength per bump after the final module reflow is about 16 cN. The results and sources of yield loss of module production are reported. The achieved yield is 95%.

  5. Load Express Analysis of the Car Running Against the Bumps in the Road

    Directory of Open Access Journals (Sweden)

    Yu. N. Baryshnikov

    2014-01-01

    Full Text Available In many fields of technology when calculating the strength there are options available to choose design cases and loads in compliance with different operating conditions. In the automotive industry there are no such standards yet. This is due to both a variety of operating conditions, and a complexity of calculating the actual loads.K. Ert`s article is considered to be a pioneering work in this regard. There the author makes a hypothesis of the linear dependence of torque acting on the car, and of the height of bumps in the road. All formulas were obtained for vehicles with the leaf spring suspensions. An appearing entire class of new cars made it necessary to generalize the experience.This paper proposes an engineering method for calculating the vertical loads acting on the car when bumping in the road. We derive general formulas to calculate the height of the road bumps (irregularities on the way of a running car with various types of suspension. A dump truck BELAZ with various types nonlinear of suspension has been used to test the obtained formulas. The results analysis has shown that under equal conditions a car with dependent rear suspension will bear the lower loads than its prototype with a different type of suspension.The paper presents the relationships between the hights of bumps, which cause an equivalent load when different wheels bump against them. It shows a relation between the loads acting on the car when bumping against the same road irregularity by different wheels. The practical significance of the equations is the possibility to calculate loads in various cases in the road using the one-test results. A comparative results analysis of analytical calculation of loads and numerical experiments is based on the nonlinear model of the vehicle.The proposed method is an effective tool for the rapid analysis of loads in the design and fine-tuning the car.

  6. Density bump formation in a collisionless electrostatic shock wave in a laser-ablated plasma

    CERN Document Server

    Garasev, M A; Kocharovsky, V V; Malkov, Yu A; Murzanev, A A; Nechaev, A A; Stepanov, A N

    2016-01-01

    The emergence of a density bump at the front of a collisionless electrostatic shock wave have been observed experimentally during the ablation of an aluminium foil by a femtosecond laser pulse. We have performed numerical simulations of the dynamics of this phenomena developing alongside the generation of a package of ion-acoustic waves, exposed to a continual flow of energetic electrons, in a collisionless plasma. We present the physical interpretation of the observed effects and show that the bump consists of transit particles, namely, the accelerated ions from the dense plasma layer, and the ions from the diluted background plasma, formed by a nanosecond laser prepulse during the ablation.

  7. The reminiscence bump for public events: A review of its prevalence and taxonomy of alternative age distributions

    DEFF Research Database (Denmark)

    Koppel, Jonathan Mark

    2013-01-01

    The present paper examines the extant literature on the reminiscence bump for public events (the finding that public events are generally remembered best by those in adolescence or early adulthood at the time of their occurrence), with the aim of identifying (i) whether this bump in fact represen...

  8. Method to Improve Indium Bump Bonding via Indium Oxide Removal Using a Multi-Step Plasma Process

    Science.gov (United States)

    Greer, H. Frank (Inventor); Jones, Todd J. (Inventor); Vasquez, Richard P. (Inventor); Hoenk, Michael E. (Inventor); Dickie, Matthew R. (Inventor); Nikzad, Shouleh (Inventor)

    2012-01-01

    A process for removing indium oxide from indium bumps in a flip-chip structure to reduce contact resistance, by a multi-step plasma treatment. A first plasma treatment of the indium bumps with an argon, methane and hydrogen plasma reduces indium oxide, and a second plasma treatment with an argon and hydrogen plasma removes residual organics. The multi-step plasma process for removing indium oxide from the indium bumps is more effective in reducing the oxide, and yet does not require the use of halogens, does not change the bump morphology, does not attack the bond pad material or under-bump metallization layers, and creates no new mechanisms for open circuits.

  9. CO2laser-induced bump formation and growth on polystyrene for multi-depth soft lithography molds

    KAUST Repository

    Li, Huawei

    2012-10-19

    This paper reports the process of creating bumps on the surface of polystyrene (PS) induced by a CO2laser at low powers. The paper also outlines the procedure for growing bumps induced by multiple laser scans on the aforementioned bumps. These bumps result from the net volume gain of the laser heat-affected zone on the PS rather than from a deposition process, and the expansion of the heat-affected zone on PS was verified by measuring the hardness change using nanoindentation. The bumps have a much smoother surface than microchannels fabricated with laser cutting; depending on the laser power, they have heights ranging from hundreds of nanometers to 42m. The laser scanning speed and scan times along with this technique offer a fast and low-cost alternative for fabricating molds for multi-depth PDMS microfluidic devices. © 2012 IOP Publishing Ltd.

  10. Precision metrology.

    Science.gov (United States)

    Jiang, X; Whitehouse, D J

    2012-08-28

    This article is a summary of the Satellite Meeting, which followed on from the Discussion Meeting at the Royal Society on 'Ultra-precision engineering: from physics to manufacture', held at the Kavli Royal Society International Centre, Chicheley Hall, Buckinghamshire, UK. The meeting was restricted to 18 invited experts in various aspects of precision metrology from academics from the UK and Sweden, Government Institutes from the UK and Germany and global aerospace industries. It examined and identified metrology problem areas that are, or may be, limiting future developments in precision engineering and, in particular, metrology. The Satellite Meeting was intended to produce a vision that will inspire academia and industry to address the solutions of those open-ended problems identified. The discussion covered three areas, namely the function of engineering parts, their measurement and their manufacture, as well as their interactions.

  11. Precision Agriculture

    DEFF Research Database (Denmark)

    Pedersen, Søren Marcus; Lind, Kim Martin Hjorth

    2017-01-01

    This chapter gives an introduction to Precision Agriculture (PA) with a short historic pathway of the development and the status of current available technologies. Part of this description also provides an overview of some of the economic barriers and technical obstacles when applying variable......-steering and Controlled Traffic Systems. Finally, the chapter looks into new developments of autonomous systems with an example of robotic seeding, farm information management in precision agriculture and different methods on the adoption of PA. The last chapter focuses on how PA can fulfil the current policy trends...

  12. Mechanical integrity evaluation of low-k device with bump shear

    Science.gov (United States)

    Su, Peng; Zhao, Jie-Hua; Pozder, Scott; Wontor, David

    2006-05-01

    The mechanical integrity of low-k dielectric films has brought many process challenges in both front-end integration and back-end assembly, mostly due to possible interfacial delamination and fractures within the low-k films. From a packaging point of view, it is important to have an assessment of the integrity of the low-k stack before the device is fully assembled and the time-consuming full package evaluation is started. Some of the methods that are presently used to evaluate devices with low-k films either do not reflect the real stress situation in a package (such as 4-point bend), or introduce a mixed die-solder failure mode (such as die pull), which makes the results hard to interpret. In this paper, an evaluation method using solder bump shear is introduced. The solder joints are electroplated with a Cu stud as part of the under bump metallization. When the testing parameters are carefully optimized, bump shear can induce a failure in the low-k stack. By analyzing the maximum load of the shear test and the characteristics of the load curves, die with different interlayer dielectric materials and locations on the die with different interconnect metal densities can be effectively differentiated. A finite-element model is established and fracture mechanics methodologies are utilized to interpret the results of the bump shear.

  13. Decomposing the sales promotion bump accounting for cross-category effects

    NARCIS (Netherlands)

    Leeflang, Peter S. H.; Selva, Josefa Parreno; Wittink, Dick R.; Dijk, Albertus Alard van

    Extant research on the decomposition of unit sales bumps due to price promotions considers these effects only within a single product category. This article introduces a framework that accommodates specific cross-category effects. Empirical results based on daily data measured at the item/SKU level

  14. Switchable bumps of a bead-embedded elastomer surface with variable adhesion.

    Science.gov (United States)

    Ohzono, T; Teraoka, K

    2017-12-13

    An extremely simple structural design of a composite material composed of an elastomer sheet and hard beads embedded at the surface is proposed to realize a shape-tunable surface; it reversibly forms bumps/undulations in response to in-plane tensile strain applied to the surface. Tribological properties such as adhesion therefore become switchable.

  15. EXTRACT

    DEFF Research Database (Denmark)

    Pafilis, Evangelos; Buttigieg, Pier Luigi; Ferrell, Barbra

    2016-01-01

    The microbial and molecular ecology research communities have made substantial progress on developing standards for annotating samples with environment metadata. However, sample manual annotation is a highly labor intensive process and requires familiarity with the terminologies used. We have the...... and text-mining-assisted curation revealed that EXTRACT speeds up annotation by 15-25% and helps curators to detect terms that would otherwise have been missed.Database URL: https://extract.hcmr.gr/......., organism, tissue and disease terms. The evaluators in the BioCreative V Interactive Annotation Task found the system to be intuitive, useful, well documented and sufficiently accurate to be helpful in spotting relevant text passages and extracting organism and environment terms. Comparison of fully manual...

  16. New PARSEC database of α-enhanced stellar evolutionary tracks and isochrones I. Calibration with 47 Tuc (NGC104) and the improvement on RGB bump

    Science.gov (United States)

    Fu, Xiaoting; Bressan, Alessandro; Marigo, Paola; Girardi, Léo; Montalbán, Josefina; Chen, Yang; Nanni, Ambra

    2018-01-01

    Precise studies on the Galactic bulge, globular cluster, Galactic halo and Galactic thick disk require stellar models with α enhancement and various values of helium content. These models are also important for extra-Galactic population synthesis studies. For this purpose we complement the existing PARSEC models, which are based on the solar partition of heavy elements, with α-enhanced partitions. We collect detailed measurements on the metal mixture and helium abundance for the two populations of 47 Tuc (NGC 104) from the literature, and calculate stellar tracks and isochrones with these α-enhanced compositions. By fitting the precise color-magnitude diagram with HST ACS/WFC data, from low main sequence till horizontal branch, we calibrate some free parameters that are important for the evolution of low mass stars like the mixing at the bottom of the convective envelope. This new calibration significantly improves the prediction of the RGB bump brightness. Comparison with the observed RGB and HB luminosity functions also shows that the evolutionary lifetimes are correctly predicted. As a further result of this calibration process, we derive the age, distance modulus, reddening, and the red giant branch mass loss for 47 Tuc. We apply the new calibration and α-enhanced mixtures of the two 47 Tuc populations ( [α/Fe] ˜0.4 and 0.2) to other metallicities. The new models reproduce the RGB bump observations much better than previous models. This new PARSEC database, with the newly updated α-enhanced stellar evolutionary tracks and isochrones, will also be part of the new stellar products for Gaia.

  17. NOAA TIFF Image - 50m Rugosity, Charleston Bump - Deep Coral Priority Areas - Whiting - (2001), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 50x50 meter cell size representing the bathymetry of the Charleston Bump off of the South Atlantic Bight, derived from...

  18. NOAA TIFF Image - 50m Multibeam Bathymetry, Charleston Bump - Deep Coral Priority Areas - Whiting - (2001), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 50x50 meter cell size representing the bathymetry of the Charleston Bump off of the South Atlantic Bight, derived from...

  19. NOAA TIFF Image - 50m Rugosity, Charleston Bump - Deep Coral Priority Areas - Whiting - (2000), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 50x50 meter cell size representing the bathymetry of the Charleston Bump off of the South Atlantic Bight, derived from...

  20. NOAA TIFF Image - 50m Singlebeam Bathymetry, Charleston Bump - Deep Coral Priority Areas - Whiting - (2000), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 50x50 meter cell size representing the bathymetry of the Charleston Bump off of the South Atlantic Bight, derived from...

  1. NOAA TIFF Image - 50m Rugosity, Charleston Bump - Deep Coral Priority Areas - Little Hales - (2003), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 30x30 meter cell size representing the bathymetry of the Charleston Bump off of the South Atlantic Bight, derived from...

  2. NOAA TIFF Image - 50m Singlebeam Slope, Charleston Bump - Deep Coral Priority Areas - Whiting - (2000), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 50x50 meter cell size representing the slope of the Charleston Bump off of the South Atlantic Bight, derived from...

  3. NOAA TIFF Image - 30m Rugosity, Charleston Bump - Deep Coral Priority Areas - Nancy Foster - (2006), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 30x30 meter cell size representing the slope (in degrees) of the 2006 multibeam bathymetry of the Charleston Bump off of...

  4. NOAA TIFF Image - 30m Rugosity, Charleston Bump - Deep Coral Priority Areas - Thomas Jefferson - (2007), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 30x30 meter cell size representing the bathymetry of the Charleston Bump off of the South Atlantic Bight, derived from...

  5. NOAA TIFF Image - 30m Slope, Charleston Bump - Deep Coral Priority Areas - Nancy Foster - (2006), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 30x30 meter cell size representing the slope (in degrees) of the 2006 multibeam bathymetry of the Charleston Bump off of...

  6. NOAA TIFF Image - 30m Rugosity, Charleston Bump - Deep Coral Priority Areas - Nancy Foster - (2006), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 30x30 meter cell size representing the 2006 multibeam bathymetry of the Charleston Bump off of the South Atlantic Bight,...

  7. NOAA TIFF Image - 30m Slope, Charleston Bump - Deep Coral Priority Areas - Little Hales- (2003), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 30x30 meter cell size representing the slope (in degrees) of themultibeam bathymetry of the Charleston Bump off of the...

  8. NOAA TIFF Image - 50m Backscatter, Charleston Bump - Deep Coral Priority Areas - Nancy Foster - (2006), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 30x30 meter cell size representing the backscatter intensity of the Charleston Bump off of the South Atlantic Bight,...

  9. Bump på vejen mod den førerløse fremtid

    DEFF Research Database (Denmark)

    Blond, Lasse

    2017-01-01

    Ingeniørerne er ikke i tvivl. Vi står på tærsklen til en tid, hvor mennesker ikke længere er nødvendige bag rattet. Men før vi når så langt, er der en række bump, vi skal have løst. Det er nemlig langt fra uden farer at overlade al kontrollen til maskinerne....

  10. Maskless Shaping of Gold Stud Bumps as High Aspect Ratio Microstructures

    Science.gov (United States)

    2010-01-01

    electrodes/reactors for coulome- try and anodic stripping voltammetry in LOC devices [3,13]. Previ- ously we have employed electroplating through resist... factors affecting pattern transfer such as the ratio of im- print area to total surface area on the template and resolution. The 50 lm deep molds were...pertinent factors such as temperature, time and initial stud bump size or available gold volume (3.19 1013 m3) were kept constant. All metrology

  11. System integration of the Utah electrode array using a biocompatible flip chip under bump metallization scheme

    Science.gov (United States)

    Bhandari, Rajmohan; Negi, Sandeep; Rieth, Loren; Toepper, Michael; Kim, Sohee; Klein, Matthias; Oppermann, Hermann; Normann, Richard A.; Solzbacher, Florian

    2007-04-01

    The advent of micro and nanotechnologies along with integrated circuit technologies has led to many exciting solutions in medical field. One of the major applications of microsystems is microelectrodes interfacing neurons for large scale in vivo sensing, deep brain stimulation and recording. For biomedical microsystems, material selection is a challenge because biocompatibility has to be considered for implantable electronic devices. We are using flip chip bonding to integrate a signal processing IC to the Utah electrode array (UEA). Conventionally the flip chip process is used to bond a die to a substrate or interposer. In this work the electrical interconnects are made from the under bump metallization (UBM) on the UEA to the solder bumps on the IC. The UBM selection and reliability is one of the critical issues in the total reliability of a flip chip bumping and interconnection technology. The UBM was optimized to achieve improved interconnect strength, and its reliability was evaluated by conducting solder ball shear strength testing. The UBM reliability was tested with two solder metallurgies including AuSn and SnCu0.7. These solders are needed to allow two reflow processes to be used, an initial higher temperature (350 °C) and a second lower temperature process (250 °C).

  12. Detection of solder bump defects on a flip chip using vibration analysis

    Science.gov (United States)

    Liu, Junchao; Shi, Tielin; Xia, Qi; Liao, Guanglan

    2012-03-01

    Flip chips are widely used in microelectronics packaging owing to the high demand of integration in IC fabrication. Solder bump defects on flip chips are difficult to detect, because the solder bumps are obscured by the chip and substrate. In this paper a nondestructive detection method combining ultrasonic excitation with vibration analysis is presented for detecting missing solder bumps, which is a typical defect in flip chip packaging. The flip chip analytical model is revised by considering the influence of spring mass on mechanical energy of the system. This revised model is then applied to estimate the flip chip resonance frequencies. We use an integrated signal generator and power amplifier together with an air-coupled ultrasonic transducer to excite the flip chips. The vibrations are measured by a laser scanning vibrometer to detect the resonance frequencies. A sensitivity coefficient is proposed to select the sensitive resonance frequency order for defect detection. Finite element simulation is also implemented for further investigation. The results of analytical computation, experiment, and simulation prove the efficacy of the revised flip chip analytical model and verify the effectiveness of this detection method. Therefore, it may provide a guide for the improvement and innovation of the flip chip on-line inspection systems.

  13. Radiographic Markers of Femoroacetabular Impingement: Correlation of Herniation Pit and Femoral Bump with a Positive Cross-Over Ratio

    Directory of Open Access Journals (Sweden)

    Max J. Scheyerer

    2014-01-01

    Full Text Available Introduction. The goal of this study was to research the association of femoral bumps and herniation pits with the overlap-ratio of the cross-over sign. Methods. Pelvic X-rays and CT-scans of 2925 patients with good assessment of the anterior and the posterior acetabular wall and absence of neutral pelvic tilt were enrolled in the investigation. Finally pelvic X-rays were assessed for the presence of a positive cross-over sign, and CT-scans for a femoral bump or a herniation pit. Additionally, if a positive cross-over sign was discovered, the overlap-ratio was calculated. Results. A femoral bump was found in 53.3% (n=1559, and a herniation pit in 27.2% (n=796 of all hips. The overlap-ratio correlated positively with the presence of a femoral bump, while a negative correlation between the overlap-ratio and the presence of a herniation pit was found. The latter was significantly more often combined with a femoral bump than without. Conclusions. We detected an increased prevalence of femoral bump with increasing overlap-ratios of the cross-over sign indicating a relation to biomechanical stress. The observed decreased prevalence of herniation pits with increasing overlap-ratios could be explained by reduced mechanical stress due to nontightened iliofemoral ligament in the presence of retroversion of the acetabulum.

  14. Precise models deserve precise measures

    Directory of Open Access Journals (Sweden)

    Benjamin E. Hilbig

    2010-07-01

    Full Text Available The recognition heuristic (RH --- which predicts non-compensatory reliance on recognition in comparative judgments --- has attracted much research and some disagreement, at times. Most studies have dealt with whether or under which conditions the RH is truly used in paired-comparisons. However, even though the RH is a precise descriptive model, there has been less attention concerning the precision of the methods applied to measure RH-use. In the current work, I provide an overview of different measures of RH-use tailored to the paradigm of natural recognition which has emerged as a preferred way of studying the RH. The measures are compared with respect to different criteria --- with particular emphasis on how well they uncover true use of the RH. To this end, both simulations and a re-analysis of empirical data are presented. The results indicate that the adherence rate --- which has been pervasively applied to measure RH-use --- is a severely biased measure. As an alternative, a recently developed formal measurement model emerges as the recommended candidate for assessment of RH-use.

  15. The 1600 Å Emission Bump in Protoplanetary Disks: A Spectral Signature of H{sub 2}O Dissociation

    Energy Technology Data Exchange (ETDEWEB)

    France, Kevin [Laboratory for Atmospheric and Space Physics, University of Colorado, 600 UCB, Boulder, CO 80309 (United States); Roueff, Evelyne; Abgrall, Hervé, E-mail: kevin.france@colorado.edu [LERMA, Observatoire de Paris, PSL Research University, CNRS, Sorbonne Universités, UPMC Univ. Paris 06, F-92190, Meudon (France)

    2017-08-01

    The FUV continuum spectrum of many accreting pre-main sequence stars, Classical T Tauri Stars (CTTSs), does not continue smoothly from the well-studied Balmer continuum emission in the NUV, suggesting that additional processes contribute to the short-wavelength emission in these objects. The most notable spectral feature in the FUV continuum of some CTTSs is a broad emission approximately centered at 1600 Å, which has been referred to as the “1600 Å Bump.” The origin of this feature remains unclear. In an effort to better understand the molecular properties of planet-forming disks and the UV spectral properties of accreting protostars, we have assembled archival FUV spectra of 37 disk-hosting systems observed by the Hubble Space Telescope -Cosmic Origins Spectrograph. Clear 1600 Å Bump emission is observed above the smooth, underlying 1100–1800 Å continuum spectrum in 19/37 Classical T Tauri disks in the HST -COS sample, with the detection rate in transition disks (8/8) being much higher than that in primordial or non-transition sources (11/29). We describe a spectral deconvolution analysis to separate the Bump (spanning 1490–1690 Å) from the underlying FUV continuum, finding an average Bump luminosity L (Bump) ≈ 7 × 10{sup 29} erg s{sup −1}. Parameterizing the Bump with a combination of Gaussian and polynomial components, we find that the 1600 Å Bump is characterized by a peak wavelength λ {sub o} = 1598.6 ± 3.3 Å, with FWHM = 35.8 ± 19.1 Å. Contrary to previous studies, we find that this feature is inconsistent with models of H{sub 2} excited by electron -impact. We show that this Bump makes up between 5%–50% of the total FUV continuum emission in the 1490–1690 Å band and emits roughly 10%–80% of the total fluorescent H{sub 2} luminosity for stars with well-defined Bump features. Energetically, this suggests that the carrier of the 1600 Å Bump emission is powered by Ly α photons. We argue that the most likely mechanism

  16. Chorionic bump in pregnant patients and associated live birth rate: a systematic review and meta-analysis.

    Science.gov (United States)

    Arleo, Elizabeth Kagan; Dunning, Allison; Troiano, Robert N

    2015-04-01

    A chorionic bump on first-trimester sonography has been considered a risk factor for nonviability in pregnant patients with this rare finding, although the strength of this association has recently been questioned. We performed a systematic review and meta-analysis to summarize the association between a chorionic bump and nonviability. A comprehensive literature search was performed. We included all studies except case reports. A meta-analysis was performed using a random-effects model. After screening 5 studies, 2 studies with a total of 67 patients met inclusion criteria. These were combined with a study (n = 52) from our institution. Overall, the live birth rate was 62% (74 of 119). Fifty-one chorionic bump pregnancies were otherwise normal (ie, pregnancies in which a gestational sac, a yolk sac, and an embryo with a heartbeat was seen at some point), and in this subset, the live birth rate was 83% (42 of 51). There was no significant relationship found between vaginal bleeding and live birth (P = .857); there was no significant difference in bump volume between live birth and no live birth (P = .198); and for the subset analysis of pooled odds ratios for the relationship between live birth and history of infertility, there was no significant relationship found (P = .186). A chorionic bump remains a risk factor for nonviability in pregnancy; however, if the pregnancy is otherwise normal, then most result in live birth. © 2015 by the American Institute of Ultrasound in Medicine.

  17. Aerodynamic Drag Reduction for a Generic Truck Using Geometrically Optimized Rear Cabin Bumps

    Directory of Open Access Journals (Sweden)

    Abdellah Ait Moussa

    2015-01-01

    Full Text Available The continuous surge in gas prices has raised major concerns about vehicle fuel efficiency, and drag reduction devices offer a promising strategy. In this paper, we investigate the mechanisms by which geometrically optimized bumps, placed on the rear end of the cabin roof of a generic truck, reduce aerodynamic drag. The incorporation of these devices requires proper choices of the size, location, and overall geometry. In the following analysis we identify these factors using a novel methodology. The numerical technique combines automatic modeling of the add-ons, computational fluid dynamics and optimization using orthogonal arrays, and probabilistic restarts. Numerical results showed reduction in aerodynamic drag between 6% and 10%.

  18. Improved Switching Characteristics of Fast Power MOSFETs Applying Solder Bump Technology

    Directory of Open Access Journals (Sweden)

    Sibylle Dieckerhoff

    2008-01-01

    Full Text Available The impact of a reduced package stray inductance on the switching performance of fast power MOSFETs is discussed applying advanced 3D packaging technologies. Starting from an overview over new packaging approaches, a solder bump technology using a flexible PI substrate is exemplarily chosen for the evaluation. Measurement techniques to determine the stray inductance are discussed and compared with a numerical solution based on the PEEC method. Experimental results show the improvement of the voltage utilization while there is only a slight impact on total switching losses.

  19. A novel approach to the bias-variance problem in bump hunting

    Science.gov (United States)

    Williams, M.

    2017-09-01

    This study explores various data-driven methods for performing background-model selection, and for assigning uncertainty on the signal-strength estimator that arises due to the choice of background model. The performance of these methods is evaluated in the context of several realistic example problems. Furthermore, a novel strategy is proposed that greatly simplifies the process of performing a bump hunt when little is assumed to be known about the background. This new approach is shown to greatly reduce the potential bias in the signal-strength estimator, without degrading the sensitivity by increasing the variance, and to produce confidence intervals with valid coverage properties.

  20. Numerical Analysis of Warpage Induced by Thermo-Compression Bonding Process of Cu Pillar Bump Flip Chip Package

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Oh Young; Jung, Hoon Sun; Lee, Jung Hoon; Choa, Sung-Hoon [Seoul Nat’l Univ. of Science and Technology, Seoul (Korea, Republic of)

    2017-06-15

    In flip chip technology, the conventional solder bump has been replaced with a copper (Cu) pillar bump owing to its higher input/output (I/O) density, finer pitch, and higher reliability. However, Cu pillar bump technology faces several issues, such as interconnect shorting and higher low-k stress due to stiffer Cu pillar structure when the conventional reflow process is used. Therefore, the thermal compression bonding (TCB) process has been adopted in the flip chip attachment process in order to reduce the package warpage and stress. In this study, we investigated the package warpage induced during the TCB process using a numerical analysis. The warpage of the TCB process was compared with that of the reflow process.

  1. Development of a reliable analytical method for the precise extractive spectrophotometric determination of osmium(VIII) with 2-nitrobenzaldehydethiocarbohydrazone: Analysis of alloys and real sample

    Science.gov (United States)

    Zanje, Sunil B.; Kokare, Arjun N.; Suryavanshi, Vishal J.; Waghmode, Duryodhan P.; Joshi, Sunil S.; Anuse, Mansing A.

    2016-12-01

    The proposed method demonstrates that the osmium(VIII) forms complex with 2-NBATCH from 0.8 mol L- 1 HCl at room temperature. The complex formed was extracted in 10 mL of chloroform with a 5 min equilibration time. The absorbance of the red colored complex was measured at 440 nm against the reagent blank. The Beer's law was obeyed in the range of 5-25 μg mL- 1, the optimum concentration range was 10-20 μg mL- 1 of osmium(VIII) as evaluated by Ringbom's plot. Molar absorptivity and Sandell's sensitivity of osmium(VIII)-2NBATCH complex in chloroform is 8.94 × 103 L mol- 1 cm- 1 and 0.021 μg cm- 2, respectively. The composition of osmium(VIII)-2NBATCH complex was 1:2 investigated from Job's method of continuous variation, Mole ratio method and slope ratio method. The interference of diverse ions was studied and masking agents were used wherever necessary. The present method was successfully applied for determination of osmium(VIII) from binary, ternary and synthetic mixtures corresponding to alloys and real samples. The validity of the method was confirmed by finding the relative standard deviation for five determinations which was 0.29%.

  2. First Measurement of the Ratio sigma_(t-tbar) / sigma_(Z/\\gamma*->ll) and Precise Extraction of the t-tbar Cross Section

    Energy Technology Data Exchange (ETDEWEB)

    Aaltonen, T.; /Helsinki Inst. of Phys.; Adelman, J.; /Chicago U., EFI; Alvarez Gonzalez, B.; /Cantabria Inst. of Phys.; Amerio, S.; /INFN, Padua; Amidei, D.; /Michigan U.; Anastassov, A.; /Northwestern U.; Annovi, A.; /Frascati; Antos, J.; /Comenius U.; Apollinari, G.; /Fermilab; Apresyan, A.; /Purdue U.; Arisawa, T.; /Waseda U. /Dubna, JINR

    2010-04-01

    We report a measurement of the ratio of the t{bar t} to Z/{gamma}* production cross sections in {radical}s = 1.96 TeV p{bar p} collisions using data corresponding to an integrated luminosity of up to 4.6 fb{sup -1}, collected by the CDF II detector. The t{bar t} cross section ratio is measured using two complementary methods, a b-jet tagging measurement and a topological approach. By multiplying the ratios by the well-known theoretical Z/{gamma}* {yields} ll cross section predicted by the standard model, the extracted t{bar t} cross sections are effectively insensitive to the uncertainty on luminosity. A best linear unbiased estimate is used to combine both measurements with the result {sigma}{sub t{bar t}} = 7.70 {+-} 0.52 pb, for a top-quark mass of 172.5 GeV/c{sup 2}.

  3. Indium-bump-free antimonide superlattice membrane detectors on silicon substrates

    Energy Technology Data Exchange (ETDEWEB)

    Zamiri, M., E-mail: mzamiri@chtm.unm.edu, E-mail: skrishna@chtm.unm.edu; Klein, B.; Schuler-Sandy, T.; Dahiya, V.; Cavallo, F. [Center for High Technology Materials, Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, New Mexico 87106 (United States); Myers, S. [SKINfrared, LLC, Lobo Venture Lab, 801 University Blvd., Suite 10, Albuquerque, New Mexico 87106 (United States); Krishna, S., E-mail: mzamiri@chtm.unm.edu, E-mail: skrishna@chtm.unm.edu [Center for High Technology Materials, Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, New Mexico 87106 (United States); SKINfrared, LLC, Lobo Venture Lab, 801 University Blvd., Suite 10, Albuquerque, New Mexico 87106 (United States)

    2016-02-29

    We present an approach to realize antimonide superlattices on silicon substrates without using conventional Indium-bump hybridization. In this approach, PIN superlattices are grown on top of a 60 nm Al{sub 0.6}Ga{sub 0.4}Sb sacrificial layer on a GaSb host substrate. Following the growth, the individual pixels are transferred using our epitaxial-lift off technique, which consists of a wet-etch to undercut the pixels followed by a dry-stamp process to transfer the pixels to a silicon substrate prepared with a gold layer. Structural and optical characterization of the transferred pixels was done using an optical microscope, scanning electron microscopy, and photoluminescence. The interface between the transferred pixels and the new substrate was abrupt, and no significant degradation in the optical quality was observed. An Indium-bump-free membrane detector was then fabricated using this approach. Spectral response measurements provided a 100% cut-off wavelength of 4.3 μm at 77 K. The performance of the membrane detector was compared to a control detector on the as-grown substrate. The membrane detector was limited by surface leakage current. The proposed approach could pave the way for wafer-level integration of photonic detectors on silicon substrates, which could dramatically reduce the cost of these detectors.

  4. High resolution 3D imaging of bump-bonds by means of synchrotron radiation computed laminography

    Science.gov (United States)

    Cecilia, A.; Hamann, E.; Koenig, T.; Xu, F.; Cheng, Y.; Helfen, L.; Ruat, M.; Scheel, M.; Zuber, M.; Baumbach, T.; Fauler, A.; Fiederle, M.

    2013-12-01

    During the flip-chip bonding process of a semiconductor sensor onto readout electronics, a formation of defects may take place, like solder joint displacements, voids, cracks, pores and bridges. This may result in blind spots on the detector, which are insensitive to photons and thus reduce the detector performance. In this work, the flip-chip interconnections of selected CdTe and GaAs Medipix detectors were investigated by synchrotron radiation computed laminography at a micrometer scale. The analysis of the volume rendering proved the presence of voids in the CdTe sensor flip-chip interconnections, with sizes between 3 μm and 9 μm. These voids can be harmful for the long term use of the device, because their presence weakens the adhesive strength between a contact and the readout electronics. Consequently, their formation needs to be avoided. The GaAs Medipix detectors investigated include two sensors that were produced with different flip-chip methods. The comparison of the 3D renderings of the bump-bond interconnections in the two GaAs sensors demonstrated the presence of a misalignment in the range of 5-12 μm between pixel passivation and bump-bonds in the detector produced with an older technique. In contrast to this, no misalignment was observed for the most recently produced detector. The only remarkable observation is the presence of ``satellites'' of solder that do not compromise the detector operation.

  5. Miniaturization of Micro-Solder Bumps and Effect of IMC on Stress Distribution

    Science.gov (United States)

    Choudhury, Soud Farhan; Ladani, Leila

    2016-07-01

    As the joints become smaller in more advanced packages and devices, intermetallic (IMCs) volume ratio increases, which significantly impacts the overall mechanical behavior of joints. The existence of only a few grains of Sn (Tin) and IMC materials results in anisotropic elastic and plastic behavior which is not detectable using conventional finite element (FE) simulation with average properties for polycrystalline material. In this study, crystal plasticity finite element (CPFE) simulation is used to model the whole joint including copper, Sn solder and Cu6Sn5 IMC material. Experimental lap-shear test results for solder joints from the literature were used to validate the models. A comparative analysis between traditional FE, CPFE and experiments was conducted. The CPFE model was able to correlate the experiments more closely compared to traditional FE analysis because of its ability to capture micro-mechanical anisotropic behavior. Further analysis was conducted to evaluate the effect of IMC thickness on stress distribution in micro-bumps using a systematic numerical experiment with IMC thickness ranging from 0% to 80%. The analysis was conducted on micro-bumps with single crystal Sn and bicrystal Sn. The overall stress distribution and shear deformation changes as the IMC thickness increases. The model with higher IMC thickness shows a stiffer shear response, and provides a higher shear yield strength.

  6. Life-span retrieval of public events: Reminiscence bump for high-impact events, recency for others.

    Science.gov (United States)

    Tekcan, Ali I; Boduroglu, Aysecan; Mutlutürk, Aysu; Aktan Erciyes, Aslı

    2017-10-01

    Although substantial evidence exists showing a reliable reminiscence bump for personal events, data regarding retrieval distributions for public events have been equivocal. The primary aim of the present study was to address life-span retrieval distributions of different types of public events in comparison to personal events, and to test whether the existing accounts of the bump can explain the distribution of public events. We asked a large national sample to report the most important, happiest, and saddest personal events and the most important, happiest, saddest, most proud, most fearful, and most shameful public events. We found a robust bump corresponding to the third decade of life for the happiest and the most important positive but not for the saddest and most important negative personal events. For the most important public events, a bump emerged only for the two most frequently mentioned events. Distributions of public events cued with emotions were marked by recency. These results point to potential differences in retrieval of important personal and public events. While the life-script framework well accounts for the findings regarding important personal events, a chronologically retroactive search seem to guide retrieval of public events. Reminiscence bump observed for the two public events suggest that age-at-event affects recall of public events to the degree that the events are high-impact ones that dominate nation's collective memory. Results provide further evidence that the bump is not unitary and points to importance of event type and memory elicitation method with regard to competing explanations of the phenomenon.

  7. Diagnostic precision of component-resolved vs. extract-based in vitro diagnosis of hymenoptera venom allergy: effects on clinical management.

    Science.gov (United States)

    Seyfarth, Florian; Miguel, Diana; Schliemann, Sibylle; Hipler, Uta-Christina

    2017-05-01

    The measurement of specific IgE (sIgE) antibodies plays a key role in the diagnosis of honeybee and wasp venom allergy. In recent years, component-resolved diagnosis (CRD) has been introduced, which allows for the measurement of sIgE antibodies against Api m 1, Ves v 1, Ves v 5, and Pol d 5, as well as cross-reactive carbohydrate determinants (CCDs). These tests are intended to help determine the clinical relevance of any given sensitization, especially in patients with dual sensitization. Specific IgE antibody levels were measured in 143 patients with bee and/or wasp venom allergy using the extract-based ImmunoCAP ® allergens i1 and i3 as well as the ImmunoCAP ® allergen components i208-211 and O214 (Api m 1, Ves v 1, Ves v 5, Pol d 5, CCDs). In patients with dual sensitization, inhibition testing was also performed. In a subgroup of the study population, sIgE to Api m 1, Api m 4, Pol d 5, and Ves v 5 were determined using the ISAC ® allergy microarray (n = 44). The sensitivity of Ves v 5 in patients with isolated wasp venom allergy was 78.5 %; in combination with Ves v 1, that figure increased to 92.3 %. The sensitivity of Api m 1 in individuals with isolated bee venom allergy was 25 %. CRD and inhibition testing in individuals with dual sensitization showed divergent results. CRD using the ISAC ® allergy microarray showed marked differences, especially with regard to Api m 1 and CCDs. Component-resolved tests are a valuable addition to the diagnostic spectrum as long as they are used in combination with established procedures. Apart from Ves v 5, measuring IgE antibodies to Ves v 1 should always be included in the diagnostic workup. © 2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

  8. Ultra-fast Movies Resolve Ultra-short Pulse Laser Ablation and Bump Formation on Thin Molybdenum Films

    Science.gov (United States)

    Domke, Matthias; Rapp, Stephan; Huber, Heinz

    For the monolithic serial interconnection of CIS thin film solar cells, 470 nm molybdenum films on glass substrates must be separated galvanically. The single pulse ablation with a 660 fs laser at a wavelength of 1053 nm is investigated in a fluence regime from 0.5 to 5.0 J/cm2. At fluences above 2.0 J/cm2 bump and jet formation can be observed that could be used for creating microstructures. For the investigation of the underlying mechanisms of the laser ablation process itself as well as of the bump or jet formation, pump probe microscopy is utilized to resolve the transient ablation behavior.

  9. Precise Point Positioning

    DEFF Research Database (Denmark)

    Zhang, Xiaohong

    could be achievable depending on the observation session length, and kinematic positioning accuracy can reach cm to dm level. Furthermore, a new method for airborne lidar system misalignment calibration was described in detail. The proposed method was a so called ‘stepwise geometric misalignment......This report presents the results of investigations to determine accurate positions of aircrafts in airborne surveys (airborne gravity and airborne lidar) using precise point positioning, and also introduces a new so called “stepwise geometric misalignment determination” method to retrieve...... determination’ based on the relationship between the point clouds on regular objects (e.g. flat top buildings) and the ground truth of the objects used for calibration. In order to extract the footprints on the objects, filtering was implemented before the calibration. Three example tests have been made...

  10. Recent versus Remote: Flashbulb Memory for 9/11 and Self-Selected Events from the Reminiscence Bump

    Science.gov (United States)

    Denver, Jenny Y.; Lane, Sean M.; Cherry, Katie E.

    2010-01-01

    In two related studies, we examined flashbulb memories acquired from different points in the lifespan in younger and older adults. When asked to remember flashbulb memories from their lives, older adults were most likely to recall events from the reminiscence bump (Study 1A). In Study 1B, younger and older adults recalled 9/11 and a personal…

  11. Design and Experimental Development of a Pneumatic Stiffness Adjustable Foot System for Biped Robots Adaptable to Bumps on the Ground

    Directory of Open Access Journals (Sweden)

    Xizhe Zang

    2017-09-01

    Full Text Available Walking on rough terrains still remains a challenge that needs to be addressed for biped robots because the unevenness on the ground can easily disrupt the walking stability. This paper proposes a novel foot system with passively adjustable stiffness for biped robots which is adaptable to small-sized bumps on the ground. The robotic foot is developed by attaching eight pneumatic variable stiffness units to the sole separately and symmetrically. Each variable stiffness unit mainly consists of a pneumatic bladder and a mechanical reversing valve. When walking on rough ground, the pneumatic bladders in contact with bumps are compressed, and the corresponding reversing valves are triggered to expel out the air, enabling the pneumatic bladders to adapt to the bumps with low stiffness; while the other pneumatic bladders remain rigid and maintain stable contact with the ground, providing support to the biped robot. The performances of the proposed foot system, including the variable stiffness mechanism, the adaptability on the bumps of different heights, and the application on a biped robot prototype are demonstrated by various experiments.

  12. Misuse of speed-bumps on two-lane main rural roads. A generalized practice in Venezuela

    Energy Technology Data Exchange (ETDEWEB)

    Calderas Volcanes, R.J.; Moreno Gonzalez, E.G.

    2016-07-01

    Settlements of uncontrolled population on side of road in Venezuela originate the excessive use of traffic speed reducers to mitigate accidents. Misuse of these speed control devices generate problem of functionality in the two-lane main rural roads which requires to be studied to demonstrate its effect on the capacity and level of service. Although other factors may occur (i.e, environmental problems and health), the disproportionate use of speed-bumps worsens circulation quality by increase of travel time as most sensitive parameter. Where this effect not can be reversed it should be made efforts to mitigate speed using another traffic-calming device. The studied stretches are selected according to particular characteristics such as: urban settlement, isolated speed-bump and its installation in series, including case without speed-bumps which guarantees the proper contrast. Video cameras to detect the travel time of vehicles are used in each road section, it allow the measures of other parameters. The travel time distribution with or without speed-bumps and probability distribution that characterizes vehicle movement in each stretch allows the simulation and modeling with the ARENA software. Travel time allows obtain the speed which, together with the volume of traffic, determines the level of service according to the Highway Capacity Manual criterion. The economic cost of substitute measures versus travel time is evaluated and may be useful in decision-making or implementation of better policies by transport governmental institutions. (Author)

  13. Solderjet bumping technique used to manufacture a compact and robust green solid-state laser

    Science.gov (United States)

    Ribes, P.; Burkhardt, T.; Hornaff, M.; Kousar, S.; Burkhardt, D.; Beckert, E.; Gilaberte, M.; Guilhot, D.; Montes, D.; Galan, M.; Ferrando, S.; Laudisio, M.; Belenguer, T.; Ibarmia, S.; Gallego, P.; Rodríguez, J. A.; Eberhardt, R.; Tünnermann, A.

    2015-06-01

    Solder-joining using metallic solder alloys is an alternative to adhesive bonding. Laser-based soldering processes are especially well suited for the joining of optical components made of fragile and brittle materials such as glasses, ceramics and optical crystals due to a localized and minimized input of thermal energy. The Solderjet Bumping technique is used to assemble a miniaturized laser resonator in order to obtain higher robustness, wider thermal conductivity performance, higher vacuum and radiation compatibility, and better heat and long term stability compared with identical glued devices. The resulting assembled compact and robust green diode-pumped solid-state laser is part of the future Raman Laser Spectrometer designed for the Exomars European Space Agency (ESA) space mission 2018.

  14. Bump evolution driven by the x-ray ablation Richtmyer-Meshkov effect in plastic inertial confinement fusion Ablators

    Directory of Open Access Journals (Sweden)

    Loomis Eric

    2013-11-01

    Full Text Available Growth of hydrodynamic instabilities at the interfaces of inertial confinement fusion capsules (ICF due to ablator and fuel non-uniformities are a primary concern for the ICF program. Recently, observed jetting and parasitic mix into the fuel were attributed to isolated defects on the outer surface of the capsule. Strategies for mitigation of these defects exist, however, they require reduced uncertainties in Equation of State (EOS models prior to invoking them. In light of this, we have begun a campaign to measure the growth of isolated defects (bumps due to x-ray ablation Richtmyer-Meshkov in plastic ablators to validate these models. Experiments used hohlraums with radiation temperatures near 70 eV driven by 15 beams from the Omega laser (Laboratory for Laser Energetics, University of Rochester, NY, which sent a ∼1.25Mbar shock into a planar CH target placed over one laser entrance hole. Targets consisted of 2-D arrays of quasi-gaussian bumps (10 microns tall, 34 microns FWHM deposited on the surface facing into the hohlraum. On-axis radiography with a saran (Cl Heα − 2.76keV backlighter was used to measure bump evolution prior to shock breakout. Shock speed measurements were also performed to determine target conditions. Simulations using the LEOS 5310 and SESAME 7592 models required the simulated laser power be turned down to 80 and 88%, respectively to match observed shock speeds. Both LEOS 5310 and SESAME 7592 simulations agreed with measured bump areal densities out to 6 ns where ablative RM oscillations were observed in previous laser-driven experiments, but did not occur in the x-ray driven case. The QEOS model, conversely, over predicted shock speeds and under predicted areal density in the bump.

  15. NEOS Data and the Origin of the 5 MeV Bump in the Reactor Antineutrino Spectrum

    Science.gov (United States)

    Huber, Patrick

    2017-01-01

    We perform a combined analysis of recent NEOS and Daya Bay data on the reactor antineutrino spectrum. This analysis includes approximately 1.5 million antineutrino events, which is the largest neutrino event sample analyzed to date. We use a double ratio which cancels flux model dependence and related uncertainties as well as the effects of the detector response model. We find at 3-4 standard deviation significance level, that plutonium-239 and plutonium-241 are disfavored as the single source for the so-called 5 MeV bump. This analysis method has general applicability and, in particular, with higher statistics data sets, will be able to shed significant light on the issue of the bump. With some caveats, this should also allow us to improve the sensitivity for sterile neutrino searches in NEOS.

  16. NOAA TIFF Image - 50m Multibeam Bathymetry, Charleston Bump - Deep Coral Priority Areas - Little Hales - (2003), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 30x30 meter cell size representing the bathymetry of the Charleston Bump off of the South Atlantic Bight, derived from...

  17. NOAA TIFF Image - 30m Rugosity, Charleston Bump - Deep Coral Priority Areas - R/V Maurice Ewing - (1997), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 30x30 meter cell size representing the bathymetry of the Charleston Bump off of the South Atlantic Bight, derived from...

  18. NOAA TIFF Image - 30m Rugosity, Charleston Bump - Deep Coral Priority Areas - R/V Maurice Ewing - (1997), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 30x30 meter cell size representing the backscatter intensity of the Charleston Bump off of the South Atlantic Bight,...

  19. NOAA TIFF Image - 30m Multibeam Bathymetry, Charleston Bump - Deep Coral Priority Areas - Nancy Foster - (2006), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 30x30 meter cell size representing the bathymetry of the Charleston Bump off of the South Atlantic Bight, derived from...

  20. NOAA TIFF Image - 30m Slope, Charleston Bump - Deep Coral Priority Areas - R/V Maurice Ewing - (1997), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 30x30 meter cell size representing the backscatter intensity of the Charleston Bump off of the South Atlantic Bight,...

  1. NOAA TIFF Image - 30m Backscatter, Charleston Bump - Deep Coral Priority Areas - NOAA Ship Thomas Jefferson - (2007), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 30x30 meter cell size representing the backscatter intensity of the Charleston Bump off of the South Atlantic Bight,...

  2. NOAA TIFF Image - 30m Multibeam Bathymetry, Charleston Bump - Deep Coral Priority Areas - Thomas Jefferson - (2007), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 30x30 meter cell size representing the bathymetry of the Charleston Bump off of the South Atlantic Bight, derived from...

  3. NOAA TIFF Image - 50m Backscatter, Charleston Bump - Deep Coral Priority Areas - NOAA Ship Thomas Jefferson - (2007), UTM 17N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains a unified GeoTiff with 30x30 meter cell size representing the backscatter intensity of the Charleston Bump off of the South Atlantic Bight,...

  4. Dependence of purple membrane bump curvature on pH and ionic strength analyzed using atomic force microscopy combined with solvent exchange.

    Science.gov (United States)

    Yokoyama, Yasunori; Yamada, Kosuke; Higashi, Yosuke; Ozaki, Satoshi; Wang, Haorang; Koito, Naoki; Watanabe, Naoya; Sonoyama, Masashi; Mitaku, Shigeki

    2014-08-07

    Purple membrane (PM), which is a membrane patch formed by the self-assembly of the membrane protein bacteriorhodopsin (bR) with archaeal lipids, is a good subject for studying the mechanism for the supramolecular structural formation of membrane proteins. Several studies have suggested that PM is not simply planar but that it has a curvature. Atomic force microscopy (AFM) studies also indicate the presence of dome-like structures (bumps) on the cytoplasmic surface of PM. PM must have a curvature to form the bump structures; therefore, bump formations will be related to a mechanism for supramolecular structural formation via self-assembly. To elucidate the effect of an asymmetric distribution of charged residues between two aqueous domains on the bump curvature, AFM topography of identical PM sheets were examined with variation of the solvent ionic strength and pH using a newly constructed solvent circulation system. The radius and height distributions of the bumps on the identical PM sheets indicated a linear correlation. The bump curvature, which was simply estimated by the slope of the distribution, became smaller with increasing KCl concentration, which suggests that tension at the cytoplasmic surface caused by electrostatic repulsive force between negatively charged amino acid residues becomes weaker by the electrostatic shielding effect. AFM observations revealed that the bump curvature remained even at high KCl concentration where the Debye length is within a few Angstroms; therefore, the contribution of the intrinsic difference between the domain sizes of bR between two sides was confirmed. Interestingly, the bump curvature was significantly increased by the addition of CaCl2 and then decreased with a similar dependency to KCl at higher CaCl2 concentration. The effect of pH on the bump curvature was also examined, where the curvature increased and reached a maximum at pH 9, while it decreased above pH 10, at which point the two-dimensional crystalline

  5. Parasitic slow extraction of extremely weak beam from a high-intensity proton rapid cycling synchrotron

    Energy Technology Data Exchange (ETDEWEB)

    Zou, Ye [University of Science and Technology of China, Hefei, Anhui 230029 (China); Institute of High Energy Physics, CAS, Yuquan Road 19B, Beijing 100049 (China); Tang, Jingyu, E-mail: tangjy@ihep.ac.cn [University of Science and Technology of China, Hefei, Anhui 230029 (China); Institute of High Energy Physics, CAS, Yuquan Road 19B, Beijing 100049 (China); Yang, Zheng; Jing, Hantao [Institute of High Energy Physics, CAS, Yuquan Road 19B, Beijing 100049 (China)

    2014-02-11

    This paper proposes a novel method to extract extremely weak beam from a high-intensity proton rapid cycling synchrotron (RCS) in the parasitic mode, while maintaining the normal fast extraction. The usual slow extraction method from a synchrotron by employing third-order resonance cannot be applied in a high-intensity RCS due to a very short flat-top at the extraction energy and the strict control on beam loss. The proposed parasitic slow extraction method moves the beam to scrape a scattering foil prior to the fast beam extraction by employing either a local orbit bump or momentum deviation or their combination, so that the halo part of the beam will be scattered. A part of the scattered particles will be extracted from the RCS and guided to the experimental area. The slow extraction process can last about a few milliseconds before the beam is extracted by the fast extraction system. The method has been applied to the RCS of China Spallation Neutron Source. With 1.6 GeV in the extraction energy, 62.5 μA in the average current and 25 Hz in the repetition rate for the RCS, the proton intensity by the slow extraction method can be up to 2×10{sup 4} protons per cycle or 5×10{sup 5} protons per second. The extracted beam has also a good time structure of approximately uniform in a spill which is required for many applications such as detector tests. Detailed studies including the scattering effect in the foil, the local orbit bump by the bump magnets and dispersive orbit bump by modifying the RF pattern, the multi-particle simulations by ORBIT and TURTLE codes, and some technical features for the extraction magnets are presented.

  6. Numerical Analysis of Wind Turbine Airfoil Aerodynamic Performance with Leading Edge Bump

    Directory of Open Access Journals (Sweden)

    Majid Asli

    2015-01-01

    Full Text Available Aerodynamic performance improvement of wind turbine blade is the key process to improve wind turbine performance in electricity generated and energy conversion in renewable energy sources concept. The flow behavior on wind turbine blades profile and the relevant phenomena like stall can be improved by some modifications. In the present paper, Humpback Whales flippers leading edge protuberances model as a novel passive stall control method was investigated on S809 as a thick airfoil. The airfoil was numerically analyzed by CFD method in Reynolds number of 106 and aerodynamic coefficients in static angle of attacks were validated with the experimental data reported by Somers in NREL. Therefore, computational results for modified airfoil with sinusoidal wavy leading edge were presented. The results revealed that, at low angles of attacks before the stall region, lift coefficient decreases slightly rather than baseline model. However, the modified airfoil has a smooth stall trend while baseline airfoil lift coefficient decreases sharply due to the separation which occurred on suction side. According to the flow physics over the airfoils, leading edge bumps act as vortex generator so vortices containing high level of momentum make the flow remain attached to the surface of the airfoil at high angle of attack and prevent it from having a deep stall.

  7. Upper slope jets inshore of the Charleston Bump - barriers to shelf-slope exchange?

    Science.gov (United States)

    Seim, H.; Edwards, C. R.; Nelson, J.

    2016-02-01

    A field program conducted in winter 2012 just inshore of the seaward deflection of the Gulf Stream at the Charleston Bump observed several week-long periods of strong equatorward along-shelf flow and elevated bottom temperatures over the upper slope and outer shelf. In sea surface temperature imagery these features resemble and appear linked to warm filaments, a known feature associated with meanders of the Gulf Stream as it traverses the southeast coast of North America. However, the character of these upper slope features is not consistent with previous observations of filaments. We here document the characteristics of the jets and suggest that these may be a form of coastal trapped wave, excited on the deep water side of the slope by meanders when the Gulf Stream position is sufficiently far offshore of the shelfbreak. When present, the jets spread onto the outer shelf, creating cross-shelf convergence between the mid- and outer shelf, possibly explaining the presence of persistent mid-shelf maxima in satellite-derived chlorophyll concentration imagery during the winter season.

  8. Gulf Stream-related warm filaments inshore of the Charleston Bump

    Science.gov (United States)

    Seim, Harvey; Edwards, Catherine

    2015-04-01

    As the Gulf Stream flows along the shelfbreak of the southeast US it is prone to frontal instabilities. Warm filaments often form along the shelfbreak, extending equatorward from the onshore crests of meanders. Moored current profiler observations, shipboard towed body and current profiler observations, and glider observations collected over the first few months of 2012 are used to describe the structure of energetic warm filaments off the coast of northern South Carolina, USA, inshore of the deflection region of the Gulf Stream known as the Charleston Bump. These filaments were found to extend to more than 100m depth, translate southwestward, and produce strong SW currents (>0.6 m/s at the surface), in contrast to previous studies which documented shallower, non-translating, filaments with weaker currents to the northeast of the study area. Filaments strongly influence the mass field on the outer shelf and upper slope, causing a depression of isosurfaces, possibly enhancing near-bottom offshore flow in frictional boundary layers. A simple geostrophic representation of the near-surface properties of a filament is compared to the observations.

  9. Does recall of a past music event invoke a reminiscence bump in young adults?

    Science.gov (United States)

    Schubert, Emery

    2016-08-01

    Many studies of the reminiscence bump (RB) in music invoke memories from different autobiographical times by using stimulus specific prompts (SSPs). This study investigated the utility of a non-SSP paradigm to determine whether the RB would emerge when participants were asked to recall a single memorable musical event from "a time long ago". The presence of a RB in response to music has not been obtained in such a manner for younger participants. Eighty-eight 20-22 year olds reported music episodes that peaked when their autobiographical age was 13-14 years. Self-selected stimuli included a range of musical styles, including classical and non-Western pop forms, such as J-pop and K-pop, as well as generational pop music, such as the Beatles. However, most participants reported pop/rock music that was contemporaneous with encoding age, providing support for the utility of published SSP paradigms using pop music. Implications for and limitations of SSP paradigms are discussed. Participants were also asked to relate the selected musical piece to current musical tastes. Most participants liked the music that they selected, with many continuing to like the music, but most also reported a general broadening of their taste, consistent with developmental literature on open-earedness.

  10. A Two Species Bump-On-Tail Model With Relaxation for Energetic Particle Driven Modes

    Science.gov (United States)

    Aslanyan, V.; Porkolab, M.; Sharapov, S. E.; Spong, D. A.

    2017-10-01

    Energetic particle driven Alfvén Eigenmodes (AEs) observed in present day experiments exhibit various nonlinear behaviours varying from steady state amplitude at a fixed frequency to bursting amplitudes and sweeping frequency. Using the appropriate action-angle variables, the problem of resonant wave-particle interaction becomes effectively one-dimensional. Previously, a simple one-dimensional Bump-On-Tail (BOT) model has proven to be one of the most effective in describing characteristic nonlinear near-threshold wave evolution scenarios. In particular, dynamical friction causes bursting mode evolution, while diffusive relaxation may give steady-state, periodic or chaotic mode evolution. BOT has now been extended to include two populations of fast particles, with one dominated by dynamical friction at the resonance and the other by diffusion; the relative size of the populations determines the temporal evolution of the resulting wave. This suggests an explanation for recent observations on the TJ-II stellarator, where a transition between steady state and bursting occured as the magnetic configuration varied. The two species model is then applied to burning plasma with drag-dominated alpha particles and diffusion-dominated ICRH accelerated minority ions. This work was supported by the US DoE and the RCUK Energy Programme [Grant Number EP/P012450/1].

  11. Speed Bumps on the Road to Sustainability - Energy Technology and Geopolitics

    Energy Technology Data Exchange (ETDEWEB)

    Mandil, C.; Taylor, P.; Van Der Linde, C.; Buchner, B.; Ramsay, W.C.; Lipponen, J.; Meier, A.; Berkeley, L.; Di Paola-Galloni, J.L.; Jaureguy-Naudin, M.; Charpin, J.M.; Segar, Ch.; Zaleski, P.; Lesourne, J.; Pires Santos, A.; Menard, D.; Neuhoff, K.; Oettinger, G.

    2011-07-01

    This document gathers the slides of the available presentations given at the 2011 issue of the annual Conference of the Ifri (French Institute of International Relations) Energy Program: 1 - An Energy revolution under way (Peter Taylor, Head of the Energy Technology Division, International Energy Agency); 2 - A look back at Cancun: 'top down' versus 'bottom up' (Barbara Buchner, Director of the CPI - Climate Policy Initiative - Venice office; 3 - CCS: Still in the Starting Blocks? (Juho Lipponen, Head of CCS Unit, International Energy Agency); 4 - Energy Efficiency: Does Anyone Care? (Alan Meier, Senior Scientist and Principal Investigator, Lawrence Berkeley National Laboratory); 5 - The Transport Sector: Anything Goes? (Jean-Luc di Paola-Galloni, Corporate Vice-President, Sustainable Development and External Affairs, Valeo Group); 6 - The Mediterranean Ring: Power or Politics? (Jean-Michel Charpin, Inspecteur General des Finances); 7 - Iran gas and Iraq oil (Chris Segar, Regional Analyst/Middle East and North Africa, International Energy Agency); 8 - Nuclear Power: New Players, New Game, New Rules (Pierre Zaleski, General delegate for the Center of Geopolitics of Energy and Raw Materials, Universite Paris-Dauphine); 9 - The Grid: a Generic Speed Bump (Antonio Pires Santos, Energy and Utilities Industry Leader, Southwest Europe, IBM); 10 - Intellectual Property Rights/Technology transfer (Dominique Menard, Partner, Hogan Lovells (Paris) LLP); 11 - Energy Markets: Conducive to Sustainability (Karsten Neuhoff, Director of the CPI - Climate Policy Initiative - Berlin office, German Institute for Economic Research, DIW Berlin)

  12. Small Magellanic Cloud Ultraviolet Dust Extinction: A Focused Study of Four Sightlines Near a Molecular Cloud with Variable 2175 A bumps

    Science.gov (United States)

    Gordon, Karl

    2015-10-01

    We propose to obtain low-resolution STIS spectra covering the entire ultraviolet for four stars in the SMC to measure their UV extinction curves and HI columns. The SMC is the critical galaxy in which to study the strong 2175 A extinction bump as the this galaxy shows sightlines with and without this feature. This proposal will increase the number of sightlines in the SMC with high quality extinction curves showing a obvious 2175 A bump from one to three. The sightlines proposed here were previously observed by Maiz Apellaniz & Rubio (2012) at very low resolution in the mid-UV using STIS slitless prism observations in a 25x25 region centered on a known molecular cloud. They found two sightlines to having obvious 2175 A bumps and two sightlines with very weak to absent bumps. New observations are needed to improve the details of the mid-UV extinction curve (e.g. 2175 A bump centroid), measure the far-UV extinction curve, and measure the HI columns. We will combine these four new high quality extinction curves with the existing 16 SMC curves and use this enhanced sample to study environmental factors that influence the presence of the 2175 A bump (e.g., gas-to-dust ratio, PAH grain mass fraction, & radiation field).

  13. Coal mine bumps as related to geologic features in the northern part of the Sunnyside District, Carbon County, Utah

    Science.gov (United States)

    Osterwald, Frank W.; Dunrud, C. Richard; Collins, Donley S.

    1993-01-01

    Coal mine bumps, which are violent, spontaneous, and often catastrophic disruptions of coal and rock, were common in the Sunnyside coal mining district, Utah, before the introduction of protective-engineering methods, modern room-and-pillar retreat mining with continuous mining machines, and particularly modern longwall mining. The coal at Sunnyside, when stressed during mining, fails continuously with many popping, snapping, and banging noises. Although most of the bumps are beneficial because they make mining easier, many of the large ones are dangerous and in the past caused injuries and fatalities, particularly with room- and-pillar mining methods used in the early mining operations. Geologic mapping of underground mine openings revealed many types of deformational features, some pre-mine and some post-mine in age. Stresses resulting from mining are concentrated near the mine openings; if openings are driven at large angles to small pre-mine deformational features, particularly shatter zones in coal, abnormal stress buildups may occur and violent bumps may result. Other geologic features, such as ripple marks, oriented sand grains, intertongued rock contacts, trace fossils, and load casts, also influence the occurrence of bumps by impeding slip of coal and rocks along bedding planes. The stress field in the coal also varies markedly because of the rough ridge and canyon topography. These features may allow excessively large stress components to accumulate. At many places, the stresses that contribute to deformation and failures of mine openings are oriented horizontally. The stratigraphy of the rocks immediately above and below the mined coal bed strongly influences the deformation of the mine openings in response to stress accumulations. Triaxial compressive testing of coal from the Sunnyside No.1 and No.3 Mines indicates that the strength of the coal increases several times as the confining (lateral) stress is increased. Strengths of cores cut from single

  14. Precision Clock Evaluation Facility

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Tests and evaluates high-precision atomic clocks for spacecraft, ground, and mobile applications. Supports performance evaluation, environmental testing,...

  15. Flow visualisation of a normal shock impinging over a rounded contour bump in a Mach 1.3 free-stream.

    Science.gov (United States)

    Lo, Kin Hing; Kontis, Konstantinos

    2017-01-01

    An experimental study has been conducted to visualise the instantaneous streamwise and spanwise flow patterns of a normal shock wave impinging over a rounded contour bump in a Mach 1.3 free-stream. A quartz-made transparent shock generator was used, so that instantaneous images could be captured during the oil-flow visualisation experiments. Fluorescent oil with three different colours was used in the surface oil-flow visualisation experiment to enhance the visualisation of flow mixing and complicated flow features that present in the flow field. Experimental data showed that the rounded contour bump could split the impinging normal shock wave into a or a series of lambda-shaped shock wave structure(s). In addition, it was found that the flow pattern and the shock wave structures that appeared over the rounded contour bump depended highly on the impinging location of the normal shock wave. The flow pattern shown in this study agreed with the findings documented in literature. Moreover, it was observed from the instantaneous oil streaks that the normal shock impinging location also affected the size and the formation location of the spanwise counter-rotating vortices downstream of the bump crest. Finally, it was concluded that the terminating shock could distort the oil streaks that left over the surface of the contour bump. Therefore, the use of the transparent normal shock wave generator is recommended when conducting experiments with normal shock wave impingement involved.

  16. The reminiscence bump without memories: The distribution of imagined word-cued and important autobiographical memories in a hypothetical 70-year-old

    DEFF Research Database (Denmark)

    Koppel, Jonathan; Berntsen, Dorthe

    2016-01-01

    of autobiographical memories per se, most notably factors that aid in their encoding or retention, by asking students to generate imagined word-cued and imagined ‘most important’ autobiographical memories of a hypothetical, prototypical 70-year-old of their own culture and gender. We compared the distribution......The reminiscence bump is the disproportionate number of autobiographical memories dating from adolescence and early adulthood. It has often been ascribed to a consolidation of the mature self in the period covered by the bump. Here we stripped away factors relating to the characteristics...... of these fictional memories with the distributions of actual word-cued and most important autobiographical memories in a sample of 61–70-year-olds. We found a striking similarity between the temporal distributions of the imagined memories and the actual memories. These results suggest that the reminiscence bump...

  17. submitter LEP precision results

    CERN Document Server

    Kawamoto, T

    2001-01-01

    Precision measurements at LEP are reviewed, with main focus on the electroweak measurements and tests of the Standard Model. Constraints placed by the LEP measurements on possible new physics are also discussed.

  18. Zeptosecond precision pulse shaping.

    Science.gov (United States)

    Köhler, Jens; Wollenhaupt, Matthias; Bayer, Tim; Sarpe, Cristian; Baumert, Thomas

    2011-06-06

    We investigate the temporal precision in the generation of ultrashort laser pulse pairs by pulse shaping techniques. To this end, we combine a femtosecond polarization pulse shaper with a polarizer and employ two linear spectral phase masks to mimic an ultrastable common-path interferometer. In an all-optical experiment we study the interference signal resulting from two temporally delayed pulses. Our results show a 2σ-precision of 300 zs = 300 × 10(-21) s in pulse-to-pulse delay. The standard deviation of the mean is 11 zs. The obtained precision corresponds to a variation of the arm's length in conventional delay stage based interferometers of 0.45 Å. We apply these precisely generated pulse pairs to a strong-field quantum control experiment. Coherent control of ultrafast electron dynamics via photon locking by temporal phase discontinuities on a few attosecond timescale is demonstrated.

  19. NCI Precision Medicine

    Science.gov (United States)

    This illustration represents the National Cancer Institute’s support of research to improve precision medicine in cancer treatment, in which unique therapies treat an individual’s cancer based on specific genetic abnormalities of that person’s tumor.

  20. Optimetrics for Precise Navigation

    Science.gov (United States)

    Yang, Guangning; Heckler, Gregory; Gramling, Cheryl

    2017-01-01

    Optimetrics for Precise Navigation will be implemented on existing optical communication links. The ranging and Doppler measurements are conducted over communication data frame and clock. The measurement accuracy is two orders of magnitude better than TDRSS. It also has other advantages of: The high optical carrier frequency enables: (1) Immunity from ionosphere and interplanetary Plasma noise floor, which is a performance limitation for RF tracking; and (2) High antenna gain reduces terminal size and volume, enables high precision tracking in Cubesat, and in deep space smallsat. High Optical Pointing Precision provides: (a) spacecraft orientation, (b) Minimal additional hardware to implement Precise Optimetrics over optical comm link; and (c) Continuous optical carrier phase measurement will enable the system presented here to accept future optical frequency standard with much higher clock accuracy.

  1. Laser precision microfabrication

    CERN Document Server

    Sugioka, Koji; Pique, Alberto

    2010-01-01

    Miniaturization and high precision are rapidly becoming a requirement for many industrial processes and products. As a result, there is greater interest in the use of laser microfabrication technology to achieve these goals. This book composed of 16 chapters covers all the topics of laser precision processing from fundamental aspects to industrial applications to both inorganic and biological materials. It reviews the sate of the art of research and technological development in the area of laser processing.

  2. Precision Experiments at LEP

    CERN Document Server

    de Boer, Wim

    2015-01-01

    The Large Electron Positron Collider (LEP) established the Standard Model (SM) of particle physics with unprecedented precision, including all its radiative corrections. These led to predictions for the masses of the top quark and Higgs boson, which were beautifully confirmed later on. After these precision measurements the Nobel Prize in Physics was awarded in 1999 jointly to 't Hooft and Veltman "for elucidating the quantum structure of electroweak interactions in physics". Another hallmark of the LEP results were the precise measurements of the gauge coupling constants, which excluded unification of the forces within the SM, but allowed unification within the supersymmetric extension of the SM. This increased the interest in Supersymmetry (SUSY) and Grand Unified Theories, especially since the SM has no candidate for the elusive dark matter, while Supersymmetry provides an excellent candidate for dark matter. In addition, Supersymmetry removes the quadratic divergencies of the SM and {\\it predicts} the Hig...

  3. Precision Muonium Spectroscopy

    CERN Document Server

    Jungmann, Klaus P

    2016-01-01

    The muonium atom is the purely leptonic bound state of a positive muon and an electron. It has a lifetime of 2.2 $\\mu$s. The absence of any known internal structure provides for precision experiments to test fundamental physics theories and to determine accurate values of fundamental constants. In particular groun dstate hyperfine structure transitions can be measured by microwave spectroscopy to deliver the muon magnetic moment. The frequency of the 1s-2s transition in the hydrogen-like atom can be determined with laser spectroscopy to obtain the muon mass. With such measurements fundamental physical interactions, in particular Quantum Electrodynamics, can also be tested at highest precision. The results are important input parameters for experiments on the muon magnetic anomaly. The simplicity of the atom enables further precise experiments, such as a search for muonium-antimuonium conversion for testing charged lepton number conservation and searches for possible antigravity of muons and dark matter.

  4. Precision genome editing

    DEFF Research Database (Denmark)

    Steentoft, Catharina; Bennett, Eric P; Schjoldager, Katrine Ter-Borch Gram

    2014-01-01

    Precise and stable gene editing in mammalian cell lines has until recently been hampered by the lack of efficient targeting methods. While different gene silencing strategies have had tremendous impact on many biological fields, they have generally not been applied with wide success in the field...... of glycobiology, primarily due to their low efficiencies, with resultant failure to impose substantial phenotypic consequences upon the final glycosylation products. Here, we review novel nuclease-based precision genome editing techniques enabling efficient and stable gene editing, including gene disruption...... by introducing single or double-stranded breaks at a defined genomic sequence. We here compare and contrast the different techniques and summarize their current applications, highlighting cases from the field of glycobiology as well as pointing to future opportunities. The emerging potential of precision gene...

  5. Improving Precision of Types

    DEFF Research Database (Denmark)

    Winther, Johnni

    mixing of unrelated types. Secondly, we present an improvement of the type checking algorithm in Java which enables the compiler to detect and ease the use of a common programming idiom called guarded casts. Thirdly, we present an improvement of the precision with which classes generated by a parser......Types in programming languages provide a powerful tool for the programmer to document the code so that a large aspect of the intent can not only be presented to fellow programmers but also be checked automatically by compilers. The precision with which types model the behavior of programs...... is crucial to the quality of these automated checks, and in this thesis we present three different improvements to the precision of types in three different aspects of the Java programming language. First we show how to extend the type system in Java with a new type which enables the detection of unintended...

  6. Precision Muonium Spectroscopy

    Science.gov (United States)

    Jungmann, Klaus P.

    2016-09-01

    The muonium atom is the purely leptonic bound state of a positive muon and an electron. It has a lifetime of 2.2 µs. The absence of any known internal structure provides for precision experiments to test fundamental physics theories and to determine accurate values of fundamental constants. In particular ground state hyperfine structure transitions can be measured by microwave spectroscopy to deliver the muon magnetic moment. The frequency of the 1s-2s transition in the hydrogen-like atom can be determined with laser spectroscopy to obtain the muon mass. With such measurements fundamental physical interactions, in particular quantum electrodynamics, can also be tested at highest precision. The results are important input parameters for experiments on the muon magnetic anomaly. The simplicity of the atom enables further precise experiments, such as a search for muonium-antimuonium conversion for testing charged lepton number conservation and searches for possible antigravity of muons and dark matter.

  7. Precision machine design

    CERN Document Server

    Slocum, Alexander H

    1992-01-01

    This book is a comprehensive engineering exploration of all the aspects of precision machine design - both component and system design considerations for precision machines. It addresses both theoretical analysis and practical implementation providing many real-world design case studies as well as numerous examples of existing components and their characteristics. Fast becoming a classic, this book includes examples of analysis techniques, along with the philosophy of the solution method. It explores the physics of errors in machines and how such knowledge can be used to build an error budget for a machine, how error budgets can be used to design more accurate machines.

  8. A passion for precision

    CERN Multimedia

    CERN. Geneva. Audiovisual Unit

    2006-01-01

    For more than three decades, the quest for ever higher precision in laser spectroscopy of the simple hydrogen atom has inspired many advances in laser, optical, and spectroscopic techniques, culminating in femtosecond laser optical frequency combs as perhaps the most precise measuring tools known to man. Applications range from optical atomic clocks and tests of QED and relativity to searches for time variations of fundamental constants. Recent experiments are extending frequency comb techniques into the extreme ultraviolet. Laser frequency combs can also control the electric field of ultrashort light pulses, creating powerful new tools for the emerging field of attosecond science.

  9. Precision electron polarimetry

    Energy Technology Data Exchange (ETDEWEB)

    Chudakov, Eugene A. [JLAB

    2013-11-01

    A new generation of precise Parity-Violating experiments will require a sub-percent accuracy of electron beam polarimetry. Compton polarimetry can provide such accuracy at high energies, but at a few hundred MeV the small analyzing power limits the sensitivity. M{\\o}ller polarimetry provides a high analyzing power independent on the beam energy, but is limited by the properties of the polarized targets commonly used. Options for precision polarimetry at ~300 MeV will be discussed, in particular a proposal to use ultra-cold atomic hydrogen traps to provide a 100\\%-polarized electron target for M{\\o}ller polarimetry.

  10. Precision QCD measurements at HERA

    Directory of Open Access Journals (Sweden)

    Pirumov Hayk

    2014-01-01

    Full Text Available A review of recent experimental results on perturbative QCD from the HERA experiments H1 and ZEUS is presented. All inclusive deep inelastic cross sections measured by the H1 and ZEUS collaborations in neutral and charged current unpolarised ep scattering are combined. They span six orders of magnitude in negative four-momentum-transfer squared, Q2, and in Bjorken x. This data set is used as the sole input to NLO and NNLO QCD analyses to determine new sets of parton distributions, HERAPDF2.0, with small experimental uncertainties and an estimate of model and parametrisation uncertainties. Also shown are new results on inclusive jet, dijet and trijet differential cross sections measured in neutral current deep inelastic scattering. The precision jet data is used to extract the strong coupling αs at NLO with small experimental errors.

  11. Precision Dairy Farming 2016

    NARCIS (Netherlands)

    Kamphuis, C.; Steeneveld, W.

    2016-01-01

    The supply of new innovative precision dairy farming technologies is steadily increasing. It aims to help farmers to be more labour efficient and to support them in their daily management decisions. At the same time, since many technologies are developed from an engineering perspective, adoption of

  12. Targets for Precision Measurements

    Science.gov (United States)

    Loveland, W.; Yao, L.; Asner, D. M.; Baker, R. G.; Bundgaard, J.; Burgett, E.; Cunningham, M.; Deaven, J.; Duke, D. L.; Greife, U.; Grimes, S.; Heffner, M.; Hill, T.; Isenhower, D.; Klay, J. L.; Kleinrath, V.; Kornilov, N.; Laptev, A. B.; Massey, T. N.; Meharchand, R.; Qu, H.; Ruz, J.; Sangiorgio, S.; Selhan, B.; Snyder, L.; Stave, S.; Tatishvili, G.; Thornton, R. T.; Tovesson, F.; Towell, D.; Towell, R. S.; Watson, S.; Wendt, B.; Wood, L.

    2014-05-01

    The general properties needed in targets (sources) for high precision, high accuracy measurements are reviewed. The application of these principles to the problem of developing targets for the Fission TPC is described. Longer term issues, such as the availability of actinide materials, improved knowledge of energy losses and straggling and the stability of targets during irradiation are also discussed.

  13. Teaching with Precision.

    Science.gov (United States)

    Raybould, Ted; Solity, Jonathan

    1982-01-01

    Use of precision teaching principles with learning problem students involves five steps: specifying performance, recording daily behavior, charting daily behavior, recording the teaching approach, and analyzing data. The approach has been successfully implemented through consultation of school psychologists in Walsall, England. (CL)

  14. Precision Muonium Spectroscopy

    NARCIS (Netherlands)

    Jungmann, Klaus P.

    2016-01-01

    The muonium atom is the purely leptonic bound state of a positive muon and an electron. It has a lifetime of 2.2 mu s. The absence of any known internal structure provides for precision experiments to test fundamental physics theories and to determine accurate values of fundamental constants. In

  15. Investigation Of The Effects Of Reflow Profile Parameters On Lead-free Solder Bump Volumes And Joint Integrity

    Science.gov (United States)

    Amalu, E. H.; Lui, Y. T.; Ekere, N. N.; Bhatti, R. S.; Takyi, G.

    2011-01-01

    The electronics manufacturing industry was quick to adopt and use the Surface Mount Technology (SMT) assembly technique on realization of its huge potentials in achieving smaller, lighter and low cost product implementations. Increasing global customer demand for miniaturized electronic products is a key driver in the design, development and wide application of high-density area array package format. Electronic components and their associated solder joints have reduced in size as the miniaturization trend in packaging continues to be challenged by printing through very small stencil apertures required for fine pitch flip-chip applications. At very narrow aperture sizes, solder paste rheology becomes crucial for consistent paste withdrawal. The deposition of consistent volume of solder from pad-to-pad is fundamental to minimizing surface mount assembly defects. This study investigates the relationship between volume of solder paste deposit (VSPD) and the volume of solder bump formed (VSBF) after reflow, and the effect of reflow profile parameters on lead-free solder bump formation and the associated solder joint integrity. The study uses a fractional factorial design (FFD) of 24-1 Ramp-Soak-Spike reflow profile, with all main effects and two-way interactions estimable to determine the optimal factorial combination. The results from the study show that the percentage change in the VSPD depends on the combination of the process parameters and reliability issues could become critical as the size of solder joints soldered on the same board assembly vary greatly. Mathematical models describe the relationships among VSPD, VSBF and theoretical volume of solder paste. Some factors have main effects across the volumes and a number of interactions exist among them. These results would be useful for R&D personnel in designing and implementing newer applications with finer-pitch interconnect.

  16. Precision Muon Physics

    CERN Document Server

    Gorringe, T P

    2015-01-01

    The muon is playing a unique role in sub-atomic physics. Studies of muon decay both determine the overall strength and establish the chiral structure of weak interactions, as well as setting extraordinary limits on charged-lepton-flavor-violating processes. Measurements of the muon's anomalous magnetic moment offer singular sensitivity to the completeness of the standard model and the predictions of many speculative theories. Spectroscopy of muonium and muonic atoms gives unmatched determinations of fundamental quantities including the magnetic moment ratio $\\mu_\\mu / \\mu_p$, lepton mass ratio $m_{\\mu} / m_e$, and proton charge radius $r_p$. Also, muon capture experiments are exploring elusive features of weak interactions involving nucleons and nuclei. We will review the experimental landscape of contemporary high-precision and high-sensitivity experiments with muons. One focus is the novel methods and ingenious techniques that achieve such precision and sensitivity in recent, present, and planned experiment...

  17. A passion for precision

    CERN Multimedia

    CERN. Geneva

    2006-01-01

    For more than three decades, the quest for ever higher precision in laser spectroscopy of the simple hydrogen atom has inspired many advances in laser, optical, and spectroscopic techniques, culminating in femtosecond laser optical frequency combs  as perhaps the most precise measuring tools known to man. Applications range from optical atomic clocks and tests of QED and relativity to searches for time variations of fundamental constants. Recent experiments are extending frequency comb techniques into the extreme ultraviolet. Laser frequency combs can also control the electric field of ultrashort light pulses, creating powerful new tools for the emerging field of attosecond science.Organiser(s): L. Alvarez-Gaume / PH-THNote: * Tea & coffee will be served at 16:00.

  18. Precision mass measurements

    CERN Document Server

    Koslowsky, V T; Ball, G C; Clifford, E T H; Davies, W G; Hagberg, E; Hardy, J C; Schmeing, H; Schrewe, U J; Sharma, K S

    1981-01-01

    A new technique analogous to the 'peak-matching' method used by mass spectroscopists is being used to measure differences in reaction Q- values to a precision of 100 eV. While at present the method is being applied to the study of charge-dependent corrections in T=1 superallowed 0/sup +/ to 0/sup +/ beta-decay matrix elements, it could easily be extended to measure mass differences of nuclei farther from beta stability. (0 refs).

  19. Possibility of high efficient beam extraction from the CERN SPS with a bent crystal. Simulation results

    Energy Technology Data Exchange (ETDEWEB)

    Scandale, W. [CERN, European Organization for Nuclear Research, CH-1211 Geneva 23 (Switzerland); Laboratoire de l' AccelerateurLineaire (LAL), Universite Paris SudOrsay, Orsay (France); INFN Sezione di Roma, Piazzale Aldo Moro 2, 00185 Rome (Italy); Kovalenko, A.D.; Taratin, A.M. [Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region (Russian Federation)

    2017-03-11

    The extraction of the SPS beam of 270 GeV/c protons assisted by a bent crystal was studied by simulation. Two methods for delivering the SPS beam onto a crystal were considered: transverse diffusion and orbit bump of the beam. It was shown that the main condition for high efficient beam extraction with a bent crystal, which is a small divergence of the incident beam, can be fulfilled. Extraction efficiency up to 99% can be reached for both methods of the beam delivering. The irradiation of the electrostatic septum wires during the beam extraction can be considerably reduced.

  20. Ultra-precision bearings

    CERN Document Server

    Wardle, F

    2015-01-01

    Ultra-precision bearings can achieve extreme accuracy of rotation, making them ideal for use in numerous applications across a variety of fields, including hard disk drives, roundness measuring machines and optical scanners. Ultraprecision Bearings provides a detailed review of the different types of bearing and their properties, as well as an analysis of the factors that influence motion error, stiffness and damping. Following an introduction to basic principles of motion error, each chapter of the book is then devoted to the basic principles and properties of a specific type of bearin

  1. Precision measurements in supersymmetry

    Energy Technology Data Exchange (ETDEWEB)

    Feng, Johnathan Lee [Stanford Univ., CA (United States)

    1995-05-01

    Supersymmetry is a promising framework in which to explore extensions of the standard model. If candidates for supersymmetric particles are found, precision measurements of their properties will then be of paramount importance. The prospects for such measurements and their implications are the subject of this thesis. If charginos are produced at the LEP II collider, they are likely to be one of the few available supersymmetric signals for many years. The author considers the possibility of determining fundamental supersymmetry parameters in such a scenario. The study is complicated by the dependence of observables on a large number of these parameters. He proposes a straightforward procedure for disentangling these dependences and demonstrate its effectiveness by presenting a number of case studies at representative points in parameter space. In addition to determining the properties of supersymmetric particles, precision measurements may also be used to establish that newly-discovered particles are, in fact, supersymmetric. Supersymmetry predicts quantitative relations among the couplings and masses of superparticles. The author discusses tests of such relations at a future e{sup +}e{sup {minus}} linear collider, using measurements that exploit the availability of polarizable beams. Stringent tests of supersymmetry from chargino production are demonstrated in two representative cases, and fermion and neutralino processes are also discussed.

  2. Precision Joining Center

    Energy Technology Data Exchange (ETDEWEB)

    Powell, J.W.; Westphal, D.A.

    1991-08-01

    A workshop to obtain input from industry on the establishment of the Precision Joining Center (PJC) was held on July 10--12, 1991. The PJC is a center for training Joining Technologists in advanced joining techniques and concepts in order to promote the competitiveness of US industry. The center will be established as part of the DOE Defense Programs Technology Commercialization Initiative, and operated by EG G Rocky Flats in cooperation with the American Welding Society and the Colorado School of Mines Center for Welding and Joining Research. The overall objectives of the workshop were to validate the need for a Joining Technologists to fill the gap between the welding operator and the welding engineer, and to assure that the PJC will train individuals to satisfy that need. The consensus of the workshop participants was that the Joining Technologist is a necessary position in industry, and is currently used, with some variation, by many companies. It was agreed that the PJC core curriculum, as presented, would produce a Joining Technologist of value to industries that use precision joining techniques. The advantage of the PJC would be to train the Joining Technologist much more quickly and more completely. The proposed emphasis of the PJC curriculum on equipment intensive and hands-on training was judged to be essential.

  3. Investigation of electroless Ni(P)/Pd/Au metallization for solder joining of optical assemblies using laser-based solderjet bumping

    Science.gov (United States)

    Burkhardt, Thomas; Mäusezahl, Max; Hornaff, Marcel; de Vries, Oliver; Kinast, Jan; Damm, Christoph; Beckert, Erik

    2017-02-01

    Solder joining is an all inorganic, adhesive free bonding technique for optical components and support structures of advanced optical systems. We established laser-based Solderjet Bumping for mounting and joining of elements with highest accuracies and stability. It has been proven for optical assemblies operating under harsh environmental conditions, high energetic or ionizing radiation, and for vacuum operation. Spaceborne instrumentation experiencing such conditions and can benefit from inorganic joining to avoid adhesives and optical cements. The metallization of components, necessary to provide solder wetting, mainly relies on well-adhering layer systems provided by physical vapor deposition (PVD). We present the investigation of electroless Ni(P)/Pd/Au plating as a cost-efficient alternative under bump metallization of complex or large components unsuitable for commercially available PVD. The electroless Ni(P)/Pd/Au plating is characterized with respect to layer adherence, solderability, and bond strength using SnAg3Cu0.5 lead-free solder alloy.

  4. Probing active-edge silicon sensors using a high precision telescope

    Energy Technology Data Exchange (ETDEWEB)

    Akiba, K. [Federal University of Rio de Janeiro, Rio de Janeiro (Brazil); Artuso, M. [Syracuse University, Syracuse, NY (United States); Beveren, V. van; Beuzekom, M. van; Boterenbrood, H. [Nikhef, Amsterdam (Netherlands); Buytaert, J.; Collins, P.; Dumps, R. [CERN, the European Organisation for Nuclear Research, Geneva (Switzerland); Heijden, B. van der [Nikhef, Amsterdam (Netherlands); Hombach, C. [University of Manchester, Manchester, Lancashire (United Kingdom); Hynds, D. [Glasgow University, Glasgow, Lanarkshire (United Kingdom); Hsu, D. [Syracuse University, Syracuse, NY (United States); John, M. [University of Oxford, Oxfordshire (United Kingdom); Koffeman, E. [Nikhef, Amsterdam (Netherlands); Leflat, A. [Lomonosov Moscow State University, Moscow (Russian Federation); Li, Y. [Tsinghua University, Beijing (China); Longstaff, I.; Morton, A. [Glasgow University, Glasgow, Lanarkshire (United Kingdom); Pérez Trigo, E. [Universidade de Santiago de Compostela, Santiago de Compostela (Spain); Plackett, R. [Diamond Light Source Ltd., Didcot, Oxfordshire (United Kingdom); and others

    2015-03-21

    The performance of prototype active-edge VTT sensors bump-bonded to the Timepix ASIC is presented. Non-irradiated sensors of thicknesses 100–200 μm and pixel-to-edge distances of 50 μm and 100 μm were probed with a beam of charged hadrons with sub-pixel precision using the Timepix telescope assembled at the SPS at CERN. The sensors are shown to be highly efficient up to a few micrometers from the physical edge of the sensor. The distortion of the electric field lines at the edge of the sensors is studied by reconstructing the streamlines of the electric field using two-pixel clusters. These results are supported by TCAD simulations. The reconstructed streamlines are used to study the field distortion as a function of the bias voltage and to apply corrections to the cluster positions at the edge.

  5. Precision Medicine in Cancer Treatment

    Science.gov (United States)

    Precision medicine helps doctors select cancer treatments that are most likely to help patients based on a genetic understanding of their disease. Learn about the promise of precision medicine and the role it plays in cancer treatment.

  6. Experimental Studies on the Effects of Thermal Bumps in the Flow-Field around a Flat Plate using a Hypersonic Wind Tunnel

    Science.gov (United States)

    2012-07-01

    without the presence of thermal bumps at hypersonic Mach number using miniature encapsulated piezo-electric pressure sensors and comparison with global...Palflash 501 (Pulse Photonics) with a focusing lens and a 2 mm wide slit, two 8 inches parabolic mirrors with 6 ft focal length, a knife edge, a set of...test section windows before focusing on the knife edge plane that is placed parallel to flow direction and the focused beam is shone on CMOS sensor

  7. Computer-based structural investigation of the SY-103 waste storage tank which contains an out-of-tolerance bottom bump

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, W.E.; England, R.L.; Friley, J.R.; Vagins, M.

    1976-03-01

    A computer-based structural analysis was performed on the inner tank of SY-103 in the 241-SY tank farm on the Hanford reservation. The objectives of this study were to determine the general stress condition of the inner tank for selected water-fill, hydrotest heights, and, to investigate the magnitude of local stresses in the vicinity of an out-of-tolerance ''bump'' on the bottom of the inner tank under a loading equivalent to the anticipated waste storage condition. Results show that the stresses induced in flat-bottomed tank, due to hydrotest water-fill are quite low until fill heights in excess of 45 feet are encountered. Filling beyond this level, circumferential membrane compressive stresses in the upper knuckle become great enough to cause concern about the possibility of buckling. If the upper knuckle portion of the tank is effectively supported by the reinforced concrete roof when fill heights of approximately 43 feet are exceeded, the calculated stresses would not develop. Investigation of the measured bottom bump in SY-103 indicates that total flattening will not quite occur under the anticipated operating conditions. Results show that there will be no localized yielding of the tank inner surface when it is filled to normal height with terminal waste slurry at Sp.Gr. = 2.0. The most severe tensile stress condition at the inner surface was slightly less than yield at expected service temperature; it occurred along the bump perimeter where service-filled, pressure flattening of the prior bump curvature caused high flexural stresses.

  8. Precision cosmological parameter estimation

    Science.gov (United States)

    Fendt, William Ashton, Jr.

    2009-09-01

    Experimental efforts of the last few decades have brought. a golden age to mankind's endeavor to understand tine physical properties of the Universe throughout its history. Recent measurements of the cosmic microwave background (CMB) provide strong confirmation of the standard big bang paradigm, as well as introducing new mysteries, to unexplained by current physical models. In the following decades. even more ambitious scientific endeavours will begin to shed light on the new physics by looking at the detailed structure of the Universe both at very early and recent times. Modern data has allowed us to begins to test inflationary models of the early Universe, and the near future will bring higher precision data and much stronger tests. Cracking the codes hidden in these cosmological observables is a difficult and computationally intensive problem. The challenges will continue to increase as future experiments bring larger and more precise data sets. Because of the complexity of the problem, we are forced to use approximate techniques and make simplifying assumptions to ease the computational workload. While this has been reasonably sufficient until now, hints of the limitations of our techniques have begun to come to light. For example, the likelihood approximation used for analysis of CMB data from the Wilkinson Microwave Anistropy Probe (WMAP) satellite was shown to have short falls, leading to pre-emptive conclusions drawn about current cosmological theories. Also it can he shown that an approximate method used by all current analysis codes to describe the recombination history of the Universe will not be sufficiently accurate for future experiments. With a new CMB satellite scheduled for launch in the coming months, it is vital that we develop techniques to improve the analysis of cosmological data. This work develops a novel technique of both avoiding the use of approximate computational codes as well as allowing the application of new, more precise analysis

  9. Precision Medicine in Cardiovascular Diseases

    Directory of Open Access Journals (Sweden)

    Yan Liu

    2017-02-01

    Full Text Available Since President Obama announced the Precision Medicine Initiative in the United States, more and more attention has been paid to precision medicine. However, clinicians have already used it to treat conditions such as cancer. Many cardiovascular diseases have a familial presentation, and genetic variants are associated with the prevention, diagnosis, and treatment of cardiovascular diseases, which are the basis for providing precise care to patients with cardiovascular diseases. Large-scale cohorts and multiomics are critical components of precision medicine. Here we summarize the application of precision medicine to cardiovascular diseases based on cohort and omic studies, and hope to elicit discussion about future health care.

  10. Precisely Tracking Childhood Death.

    Science.gov (United States)

    Farag, Tamer H; Koplan, Jeffrey P; Breiman, Robert F; Madhi, Shabir A; Heaton, Penny M; Mundel, Trevor; Ordi, Jaume; Bassat, Quique; Menendez, Clara; Dowell, Scott F

    2017-07-01

    Little is known about the specific causes of neonatal and under-five childhood death in high-mortality geographic regions due to a lack of primary data and dependence on inaccurate tools, such as verbal autopsy. To meet the ambitious new Sustainable Development Goal 3.2 to eliminate preventable child mortality in every country, better approaches are needed to precisely determine specific causes of death so that prevention and treatment interventions can be strengthened and focused. Minimally invasive tissue sampling (MITS) is a technique that uses needle-based postmortem sampling, followed by advanced histopathology and microbiology to definitely determine cause of death. The Bill & Melinda Gates Foundation is supporting a new surveillance system called the Child Health and Mortality Prevention Surveillance network, which will determine cause of death using MITS in combination with other information, and yield cause-specific population-based mortality rates, eventually in up to 12-15 sites in sub-Saharan Africa and south Asia. However, the Gates Foundation funding alone is not enough. We call on governments, other funders, and international stakeholders to expand the use of pathology-based cause of death determination to provide the information needed to end preventable childhood mortality.

  11. Precisely predictable Dirac observables

    CERN Document Server

    Cordes, Heinz Otto

    2006-01-01

    This work presents a "Clean Quantum Theory of the Electron", based on Dirac’s equation. "Clean" in the sense of a complete mathematical explanation of the well known paradoxes of Dirac’s theory, and a connection to classical theory, including the motion of a magnetic moment (spin) in the given field, all for a charged particle (of spin ½) moving in a given electromagnetic field. This theory is relativistically covariant, and it may be regarded as a mathematically consistent quantum-mechanical generalization of the classical motion of such a particle, à la Newton and Einstein. Normally, our fields are time-independent, but also discussed is the time-dependent case, where slightly different features prevail. A "Schroedinger particle", such as a light quantum, experiences a very different (time-dependent) "Precise Predictablity of Observables". An attempt is made to compare both cases. There is not the Heisenberg uncertainty of location and momentum; rather, location alone possesses a built-in uncertainty ...

  12. Precise Truss Assembly Using Commodity Parts and Low Precision Welding

    Science.gov (United States)

    Komendera, Erik; Reishus, Dustin; Dorsey, John T.; Doggett, W. R.; Correll, Nikolaus

    2014-01-01

    Hardware and software design and system integration for an intelligent precision jigging robot (IPJR), which allows high precision assembly using commodity parts and low-precision bonding, is described. Preliminary 2D experiments that are motivated by the problem of assembling space telescope optical benches and very large manipulators on orbit using inexpensive, stock hardware and low-precision welding are also described. An IPJR is a robot that acts as the precise "jigging", holding parts of a local structure assembly site in place, while an external low precision assembly agent cuts and welds members. The prototype presented in this paper allows an assembly agent (for this prototype, a human using only low precision tools), to assemble a 2D truss made of wooden dowels to a precision on the order of millimeters over a span on the order of meters. The analysis of the assembly error and the results of building a square structure and a ring structure are discussed. Options for future work, to extend the IPJR paradigm to building in 3D structures at micron precision are also summarized.

  13. [Precision nutrition in the era of precision medicine].

    Science.gov (United States)

    Chen, P Z; Wang, H

    2016-12-06

    Precision medicine has been increasingly incorporated into clinical practice and is enabling a new era for disease prevention and treatment. As an important constituent of precision medicine, precision nutrition has also been drawing more attention during physical examinations. The main aim of precision nutrition is to provide safe and efficient intervention methods for disease treatment and management, through fully considering the genetics, lifestyle (dietary, exercise and lifestyle choices), metabolic status, gut microbiota and physiological status (nutrient level and disease status) of individuals. Three major components should be considered in precision nutrition, including individual criteria for sufficient nutritional status, biomarker monitoring or techniques for nutrient detection and the applicable therapeutic or intervention methods. It was suggested that, in clinical practice, many inherited and chronic metabolic diseases might be prevented or managed through precision nutritional intervention. For generally healthy populations, because lifestyles, dietary factors, genetic factors and environmental exposures vary among individuals, precision nutrition is warranted to improve their physical activity and reduce disease risks. In summary, research and practice is leading toward precision nutrition becoming an integral constituent of clinical nutrition and disease prevention in the era of precision medicine.

  14. The Hubble Space Telescope UV Legacy Survey of Galactic Globular Clusters - XII. The RGB Bumps of multiple stellar populations★

    Science.gov (United States)

    Lagioia, E. P.; Milone, A. P.; Marino, A. F.; Cassisi, S.; Aparicio, A. J.; Piotto, G.; Anderson, J.; Barbuy, B.; Bedin, L. R.; Bellini, A.; Brown, T.; D'Antona, F.; Nardiello, D.; Ortolani, S.; Pietrinferni, A.; Renzini, A.; Salaris, M.; Sarajedini, A.; van der Marel, R.; Vesperini, E.

    2018-01-01

    The Hubble Space Telescope UV Legacy Survey of Galactic Globular Clusters is providing a major breakthrough in our knowledge of Globular Clusters (GCs) and their stellar populations. Among the main results, we discovered that all the studied GCs host two main discrete groups consisting of first generation (1G) and second generation (2G) stars. We exploit the multiwavelength photometry from this project to investigate, for the first time, the Red Giant Branch Bump (RGBB) of the two generations in a large sample of GCs. We identified, with high statistical significance, the RGBB of 1G and 2G stars in 26 GCs and found that their magnitude separation as a function of the filter wavelength follows comparable trends. The comparison of observations to synthetic spectra reveals that the RGBB luminosity depends on the stellar chemical composition and that the 2G RGBB is consistent with stars enhanced in He and N and depleted in C and O with respect to 1G stars. For metal-poor GCs the 1G and 2G RGBB relative luminosity in optical bands mostly depends on helium content, Y. We used the RGBB observations in F606W and F814W bands to infer the relative helium abundance of 1G and 2G stars in 18 GCs, finding an average helium enhancement Δ Y = 0.011± 0.002 of 2G stars with respect to 1G stars. This is the first determination of the average difference in helium abundance of multiple populations in a large number of clusters and provides a lower limit to the maximum internal variation of helium in GCs.

  15. Precision physics with QCD

    Science.gov (United States)

    Pich, Antonio

    2017-03-01

    The four-loop determination of the strong coupling from fully inclusive observables is reviewed. Special attention is given to the low-energy measurement extracted from the hadronic τ decay width. A recent exhaustive analysis of the ALEPH data, exploring several complementary methodologies with very different sensitivities to inverse power corrections and duality violations, confirms the strong suppression of non-perturbative contributions to Rτ. It gives the value αs(mτ2) = 0.328, which implies αs(MZ2) = 0.1197 ± 0.0015. The excellent agreement with the direct measurement at the Z peak, αs(MZ2) = 0.1196 ± 0.0030, provides a beautiful test of asymptotic freedom. Together with the most recent lattice average from FLAG and the NNLO determinations from e+e-, PDFs and collider data quoted by the PDG, these two inclusive determinations imply a world average value αs(MZ2) = 0.1180 ± 0.0010.

  16. Precision physics with QCD

    Directory of Open Access Journals (Sweden)

    Pich Antonio

    2017-01-01

    Full Text Available The four-loop determination of the strong coupling from fully inclusive observables is reviewed. Special attention is given to the low-energy measurement extracted from the hadronic τ decay width. A recent exhaustive analysis of the ALEPH data, exploring several complementary methodologies with very different sensitivities to inverse power corrections and duality violations, confirms the strong suppression of non-perturbative contributions to Rτ. It gives the value αs(mτ2 = 0.328, which implies αs(MZ2 = 0.1197 ± 0.0015. The excellent agreement with the direct measurement at the Z peak, αs(MZ2 = 0.1196 ± 0.0030, provides a beautiful test of asymptotic freedom. Together with the most recent lattice average from FLAG and the NNLO determinations from e+e−, PDFs and collider data quoted by the PDG, these two inclusive determinations imply a world average value αs(MZ2 = 0.1180 ± 0.0010.

  17. Precision measurements of linear scattering density using muon tomography

    Science.gov (United States)

    Åström, E.; Bonomi, G.; Calliari, I.; Calvini, P.; Checchia, P.; Donzella, A.; Faraci, E.; Forsberg, F.; Gonella, F.; Hu, X.; Klinger, J.; Sundqvist Ökvist, L.; Pagano, D.; Rigoni, A.; Ramous, E.; Urbani, M.; Vanini, S.; Zenoni, A.; Zumerle, G.

    2016-07-01

    We demonstrate that muon tomography can be used to precisely measure the properties of various materials. The materials which have been considered have been extracted from an experimental blast furnace, including carbon (coke) and iron oxides, for which measurements of the linear scattering density relative to the mass density have been performed with an absolute precision of 10%. We report the procedures that are used in order to obtain such precision, and a discussion is presented to address the expected performance of the technique when applied to heavier materials. The results we obtain do not depend on the specific type of material considered and therefore they can be extended to any application.

  18. More Questions on Precision Teaching.

    Science.gov (United States)

    Raybould, E. C.; Solity, J. E.

    1988-01-01

    Precision teaching can accelerate basic skills progress of special needs children. Issues discussed include using probes as performance tests, charting daily progress, using the charted data to modify teaching methods, determining appropriate age levels, assessing the number of students to be precision taught, and carefully allocating time. (JDD)

  19. High-Precision Timing of Millisecond Pulsars and Precision Astrometry

    Science.gov (United States)

    Kaspi, V.

    1994-01-01

    We present the technique of long-term, high-precision timing of millisecond pulsars as applied to precision astrometry. We provide a tutorial on pulsars and pulsar timing, as well as up-to-date results of long-term observation of two millisecond pulsars. We consider the feasibility of tying the extragalactic and optical reference frames to that defined by solar system objects, and we conclude that precision astrometry from millisecond pulsar timing will continue to yield interesting results at an accelerating pace in the next decade.

  20. Can precision medicine reduce overdiagnosis?

    Science.gov (United States)

    Hunt, Stephen; Jha, Saurabh

    2015-08-01

    Precision Medicine promises to get the right patient, the right test, the right diagnosis, the right treatment, and in the right amount. Is this hope or hype? Copyright © 2015 AUR. Published by Elsevier Inc. All rights reserved.

  1. FROM PERSONALIZED TO PRECISION MEDICINE

    Directory of Open Access Journals (Sweden)

    K. V. Raskina

    2017-01-01

    Full Text Available The need to maintain a high quality of life against a backdrop of its inevitably increasing duration is one of the main problems of modern health care. The concept of "right drug to the right patient at the right time", which at first was bearing the name "personalized", is currently unanimously approved by international scientific community as "precision medicine". Precision medicine takes all the individual characteristics into account: genes diversity, environment, lifestyles, and even bacterial microflora and also involves the use of the latest technological developments, which serves to ensure that each patient gets assistance fitting his state best. In the United States, Canada and France national precision medicine programs have already been submitted and implemented. The aim of this review is to describe the dynamic integration of precision medicine methods into routine medical practice and life of modern society. The new paradigm prospects description are complemented by figures, proving the already achieved success in the application of precise methods for example, the targeted therapy of cancer. All in all, the presence of real-life examples, proving the regularity of transition to a new paradigm, and a wide range  of technical and diagnostic capabilities available and constantly evolving make the all-round transition to precision medicine almost inevitable.

  2. Implementation of the proposed multi-turn extraction at the CERN Proton Synchrotron

    CERN Document Server

    Giovannozzi, Massimo

    2006-01-01

    Following the positive results of the three-year measurement campaign at the CERN Proton Synchrotron, concerning beam splitting with stable islands in the transverse phase space, a study of a possible implementation of the proposed Multi-Turn Extraction (MTE) was undertaken. The novel approach would allow a substantial reduction of beam losses, with respect to the present scheme, when delivering the high-intensity proton beams required for the planned CERN Neutrino to Gran Sasso Project (CNGS). Major modifications to the ring layout are foreseen, such as a new design of the extraction bumps including also the installation of three additional kickers to create a closed-bump over the five turns used to extract the split beam. The ring aperture was reviewed and improvements proposed to reduce possible beam losses during beam splitting and extraction. The goal consists of implementing the proposed changes by the end of the 2007/2008 PS shutdown and to commission the novel extraction during the 2008 physics run.

  3. Introduction to precise numerical methods

    CERN Document Server

    Aberth, Oliver

    2007-01-01

    Precise numerical analysis may be defined as the study of computer methods for solving mathematical problems either exactly or to prescribed accuracy. This book explains how precise numerical analysis is constructed. The book also provides exercises which illustrate points from the text and references for the methods presented. All disc-based content for this title is now available on the Web. · Clearer, simpler descriptions and explanations ofthe various numerical methods· Two new types of numerical problems; accurately solving partial differential equations with the included software and computing line integrals in the complex plane.

  4. Sensing technologies for precision irrigation

    CERN Document Server

    Ćulibrk, Dubravko; Minic, Vladan; Alonso Fernandez, Marta; Alvarez Osuna, Javier; Crnojevic, Vladimir

    2014-01-01

    This brief provides an overview of state-of-the-art sensing technologies relevant to the problem of precision irrigation, an emerging field within the domain of precision agriculture. Applications of wireless sensor networks, satellite data and geographic information systems in the domain are covered. This brief presents the basic concepts of the technologies and emphasizes the practical aspects that enable the implementation of intelligent irrigation systems. The authors target a broad audience interested in this theme and organize the content in five chapters, each concerned with a specific technology needed to address the problem of optimal crop irrigation. Professionals and researchers will find the text a thorough survey with practical applications.

  5. Ultrafast, high precision gated integrator

    Energy Technology Data Exchange (ETDEWEB)

    Wang, X.

    1995-01-01

    An ultrafast, high precision gated integrator has been developed by introducing new design approaches that overcome the problems associated with earlier gated integrator circuits. The very high speed is evidenced by the output settling time of less than 50 ns and 20 MHz input pulse rate. The very high precision is demonstrated by the total output offset error of less than 0.2mV and the output droop rate of less than 10{mu}V/{mu}s. This paper describes the theory of this new gated integrator circuit operation. The completed circuit test results are presented.

  6. Origin and history of the Charleston Bump - Geological formations, currents, bottom conditions, and their relationship to wreckfish habitats on the Blake Plateau

    Science.gov (United States)

    Popenoe, P.; Manheim, F. T.

    2001-01-01

    The Charleston Bump is a structural and topographic high on the northern Blake Plateau that overlies a seaward offset of the edge of continental crust. The feature causes the bottom to shoal and deflects the Gulf Stream offshore, causing an intensification of bottom currents. The area has been swept by strong currents since late Cretaceous time, but the strongest currents have occurred in the Neogene (last ???25 million years). Nondepositional conditions prevail at present, but erosion of the bottom is checked where the bottom is armored by a hard surficial layer of phosphorite pavement. The phosphorite pavements were formed by re-cementation of eroded residues of phosphorite-rich sediments of early-Neogene age. In some places there are multiple pavements separated by poorly lithified sediments. Submersible observations indicate that the south, or current-facing flank of the Charleston Bump has several deep (>100 m) scour depressions, the southern flanks of which form cliffs characterized by ledges and overhangs. In other areas discrete layers of older Paleogene rocks have been partly eroded away, leaving cliff-like steps of 5 m or more relief. Conglomeratic phosphorite pavement layers up to 1 m thick armor most of the bottom. Where breached by scour, these pavements form both low-relief ledges and rock piles. These features form a reef-like environment of caves and overhangs utilized by wreckfish Polyprion americanus and barrelfish Hyperoglyphe perciformis as shelter from the current and as staging areas to prey on passing schools of squid. Wreckfish and other large fish were often localized in rugged bottom habitat, including caves and other shelter areas. We observed wreckfish darting from shelters to feed on passing schools of squid. Present and past observations, are consistent with the concept that impingement of the Gulf Stream at the Charleston Bump compresses midwater fauna from much thicker water layers, providing food for a flourishing big-fish fauna

  7. Blood pressure self-monitoring in pregnancy (BuMP) feasibility study; a qualitative analysis of women's experiences of self-monitoring.

    Science.gov (United States)

    Hinton, Lisa; Tucker, Katherine L; Greenfield, Sheila M; Hodgkinson, James A; Mackillop, Lucy; McCourt, Christine; Carver, Trisha; Crawford, Carole; Glogowska, Margaret; Locock, Louise; Selwood, Mary; Taylor, Kathryn S; McManus, Richard J

    2017-12-19

    Hypertensive disorders in pregnancy are a leading cause of maternal and fetal morbidity worldwide. Raised blood pressure (BP) affects 10% of pregnancies worldwide, of which almost half develop pre-eclampsia. The proportion of pregnant women who have risk factors for pre-eclampsia (such as pre-existing hypertension, obesity and advanced maternal age) is increasing. Pre-eclampsia can manifest itself before women experience symptoms and can develop between antenatal visits. Incentives to improve early detection of gestational hypertensive disorders are therefore strong and self-monitoring of blood pressure (SMBP) in pregnancy might be one means to achieve this, whilst improving women's involvement in antenatal care. The Blood Pressure Self-Monitoring in Pregnancy (BuMP) study aimed to evaluate the feasibility and acceptability of SMBP in pregnancy. To understand women's experiences of SMBP during pregnancy, we undertook a qualitative study embedded within the BuMP observational feasibility study. Women who were at higher risk of developing hypertension and/or pre-eclampsia were invited to take part in a study using SMBP and also invited to take part in an interview. Semi-structured interviews were conducted at the women's homes in Oxfordshire and Birmingham with women who were self-monitoring their BP as part of the BuMP feasibility study in 2014. Interviews were conducted by a qualitative researcher and transcribed verbatim. A framework approach was used for analysis. Fifteen women agreed to be interviewed. Respondents reported general willingness to engage with monitoring their own BP, feeling that it could reduce anxiety around their health during pregnancy, particularly if they had previous experience of raised BP or pre-eclampsia. They felt able to incorporate self-monitoring into their weekly routines, although this was harder post-partum. Self-monitoring of BP made them more aware of the risks of hypertension and pre-eclampsia in pregnancy. Feelings of

  8. Precision Teaching ... and All That!

    Science.gov (United States)

    Raybould, E. C.; Solity, J. E.

    1988-01-01

    Two proponents of the precision teaching approach to teaching the handicapped discuss such principles as: the problem of partial application of the method; relationship to behaviorism; relationship to experiential learning; and the importance of fluency in task performance, mastery learning, and recordkeeping. (DB)

  9. Spin and precision electroweak physics

    Energy Technology Data Exchange (ETDEWEB)

    Marciano, W.J. [Brookhaven National Lab., Upton, NY (United States)

    1994-12-01

    A perspective on fundamental parameters and precision tests of the Standard Model is given. Weak neutral current reactions are discussed with emphasis on those processes involving (polarized) electrons. The role of electroweak radiative corrections in determining the top quark mass and probing for {open_quotes}new physics{close_quotes} is described.

  10. Future challenges for precision QCD

    CERN Document Server

    2016-01-01

    Precision measurements at Run II of the LHC continue to demand smaller theoretical uncertainties. In this meeting we aim to bring together experts in the field to discuss current issues in the theoretical models. Topics of particular interest are Higgs and Top quark physics, new techniques for infrared subtraction and loop integrals as well as fixed order and parton shower matching beyond NLO.

  11. Precision muon lifetime at PSI

    Energy Technology Data Exchange (ETDEWEB)

    Mulhauser, Francoise [University of Illinois at Urbana-Champaign (United States) and Paul Scherrer Institute (Switzerland)

    2006-05-15

    The goal of MuLan, positive muon lifetime measurement, is the measurement of the positive muon lifetime to 1 ppm, which will in turn determine the Fermi coupling constant G {sub F} to 0.5 ppm precision. We will describe our experimental efforts and latest achievements.

  12. Precision Machining Technology. Curriculum Guide.

    Science.gov (United States)

    Idaho State Dept. of Education, Boise. Div. of Vocational Education.

    This curriculum guide was developed from a Technical Committee Report prepared with the assistance of industry personnel and containing a Task List which is the basis of the guide. It presents competency-based program standards for courses in precision machining technology and is part of the Idaho Vocational Curriculum Guide Project, a cooperative…

  13. Transient and steady state behaviour of elasto–aerodynamic air foil bearings, considering bump foil compliance and top foil inertia and flexibility: A numerical investigation

    DEFF Research Database (Denmark)

    Nielsen, Bo Bjerregaard; Santos, Ilmar F.

    2017-01-01

    This work gives a theoretical contribution to the problem of modelling air foil bearings considering large sagging effects in the calculation of the non-linear transient and steady state response of a rigid rotor. This paper consists of two parts: the development of a miltiphysics model of the air...... foils and one air foil bearing with a fully supported top foil. The steady state responses of a journal supported by these air foil bearings are investigated for varied rotational speeds and journal unbalances as well as the top foil sagging in the unsupported area. The study reveals that sub......-harmonic vibrations associated with a large journal unbalance can be eliminated by a proper design layout of the bump foil, i.e. placement of the unsupported area. The positive effect is attributed to ‘equivalent shallow pockets’ formed by the sagging top foil....

  14. Precision Quantum Chromodynamics From Heavy Quark Expansions

    CERN Document Server

    Benson, D G

    2005-01-01

    The heavy quark expansion is applied to the semileptonic width of b → c and b → u transitions along with the moments of various decay distributions in the semileptonic b → c transitions. The resulting expressions can be used to improve the precision with which we can extract the values of the CKM matrix elements Vcb and Vub from the data. Heavy quark parameters like mb and m2p are also obtained with values that are completely consistent with theoretical expectations. The observed agreement between the theoretical predictions of the heavy quark expansion and the experimental data tightly constrain the theoretical uncertainty. The heavy quark expansion can also be applied to the photon energy moments in B → Xsγ. The first two of these moments are directly related to mb and m2p . The experimentally imposed cuts on the photon energy spectrum introduce biases into the extracted values of these parameters. Correcting for these biases generates a remarkable agreem...

  15. Precision and reproducibility in AMS radiocarbon measurements.

    Energy Technology Data Exchange (ETDEWEB)

    Hotchkis, M.A.; Fink, D.; Hua, Q.; Jacobsen, G.E.; Lawson, E. M.; Smith, A.M.; Tuniz, C. [Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW (Australia)

    1996-12-31

    Accelerator Mass Spectrometry (AMS) is a technique by which rare radioisotopes such as {sup 14}C can be measured at environmental levels with high efficiency. Instead of detecting radioactivity, which is very weak for long-lived environmental radioisotopes, atoms are counted directly. The sample is placed in an ion source, from which a negative ion beam of the atoms of interest is extracted, mass analysed, and injected into a tandem accelerator. After stripping to positive charge states in the accelerator HV terminal, the ions are further accelerated, analysed with magnetic and electrostatic devices and counted in a detector. An isotopic ratio is derived from the number of radioisotope atoms counted in a given time and the beam current of a stable isotope of the same element, measured after the accelerator. For radiocarbon, {sup 14}C/{sup 13}C ratios are usually measured, and the ratio of an unknown sample is compared to that of a standard. The achievable precision for such ratio measurements is limited primarily by {sup 14}C counting statistics and also by a variety of factors related to accelerator and ion source stability. At the ANTARES AMS facility at Lucas Heights Research Laboratories we are currently able to measure {sup 14}C with 0.5% precision. In the two years since becoming operational, more than 1000 {sup 14}C samples have been measured. Recent improvements in precision for {sup 14}C have been achieved with the commissioning of a 59 sample ion source. The measurement system, from sample changing to data acquisition, is under common computer control. These developments have allowed a new regime of automated multi-sample processing which has impacted both on the system throughput and the measurement precision. We have developed data evaluation methods at ANTARES which cross-check the self-consistency of the statistical analysis of our data. Rigorous data evaluation is invaluable in assessing the true reproducibility of the measurement system and aids in

  16. The technology of extracting gaseous fuel based on comprehensive in situ gasification and coalbed degassing

    Directory of Open Access Journals (Sweden)

    А. Н. Шабаров

    2016-08-01

    Full Text Available The study considers a comprehensive technology (designed and patented by the authors of developing coal and methane deposits which combines in situ gasification of lower coalbeds in the suite of rock bump hazardous gassy beds, extraction of coal methane and mechanized mining of coal. The first stage of the technology consists in mining gaseous fuel that enables one to extract up to 15-20 % of total energy from the suite of coalbeds. Geodynamic zoning is used to select positions for boring wells. Using the suggested technology makes it possible to solve a number of tasks simultaneously. First of all that is extracting gaseous fuel from the suite of coalbeds without running any mining works while retaining principal coalbeds in the suite and preparing them for future processing (unloading and degassing. During the first phase the methane-coal deposit works as a gas deposit only, the gas having two sources – extracted methane (which includes its locked forms, absorbed and adsorbed and the products of partial incineration of thin coalbeds, riders and seams from thee suite. The second stage consists in deep degassing and unloading of coal beds which sharply reduces the hazards of methane explosion and rock bumps, thus increasing the productivity of mechanized coal mining. During the second stage coal is mined in long poles with the account of degassing and unloading of coal beds, plus the data on gas dynamic structure of coal rock massif.

  17. Precision Calculations in Supersymmetric Theories

    Directory of Open Access Journals (Sweden)

    L. Mihaila

    2013-01-01

    Full Text Available In this paper we report on the newest developments in precision calculations in supersymmetric theories. An important issue related to this topic is the construction of a regularization scheme preserving simultaneously gauge invariance and supersymmetry. In this context, we discuss in detail dimensional reduction in component field formalism as it is currently the preferred framework employed in the literature. Furthermore, we set special emphasis on the application of multi-loop calculations to the analysis of gauge coupling unification, the prediction of the lightest Higgs boson mass, and the computation of the hadronic Higgs production and decay rates in supersymmetric models. Such precise theoretical calculations up to the fourth order in perturbation theory are required in order to cope with the expected experimental accuracy on the one hand and to enable us to distinguish between the predictions of the Standard Model and those of supersymmetric theories on the other hand.

  18. Precision electroweak physics at LEP

    Energy Technology Data Exchange (ETDEWEB)

    Mannelli, M.

    1994-12-01

    Copious event statistics, a precise understanding of the LEP energy scale, and a favorable experimental situation at the Z{sup 0} resonance have allowed the LEP experiments to provide both dramatic confirmation of the Standard Model of strong and electroweak interactions and to place substantially improved constraints on the parameters of the model. The author concentrates on those measurements relevant to the electroweak sector. It will be seen that the precision of these measurements probes sensitively the structure of the Standard Model at the one-loop level, where the calculation of the observables measured at LEP is affected by the value chosen for the top quark mass. One finds that the LEP measurements are consistent with the Standard Model, but only if the mass of the top quark is measured to be within a restricted range of about 20 GeV.

  19. Higgs Precision Measurements with ATLAS

    CERN Document Server

    Boumediene, Djamel Eddine; The ATLAS collaboration

    2017-01-01

    After the discovery of the Higgs boson, precise measurements of its properties are of particular importance to understand the true nature of the found particle, which could be the Standard Model predicted Higgs, or indeed offering to be a portal for new physics beyond the Standard Model. In this talk measurement of the mass, cross sections and the couplings of the Higgs boson in bosonic and fermionic decay channels with the ATLAS detector will be presented and compared with Standard Model predictions.

  20. Precision measurements of electroweak parameters

    CERN Document Server

    Savin, Alexander

    2017-01-01

    A set of selected precise measurements of the SM parameters from the LHC experiments is discussed. Results on W-mass measurement and forward-backward asymmetry in production of the Drell--Yan events in both dielectron and dimuon decay channels are presented together with results on the effective mixing angle measurements. Electroweak production of the vector bosons in association with two jets is discussed.

  1. Numerical precision and data structures

    Science.gov (United States)

    Schenk, W.

    1978-01-01

    Technical proposals and recommendations for revising FORTRAN were studied and categorized. In the area of numerical precision, the proposals basically agree on a set of necessary parameters, although a wide range of nomenclature and specific function names are used. Environmental parameters identified include the following: (1) base of floating point representation, (2) largest positive real number, exponent and integer, (3) largest negative real number, exponent and integer, (4) number of significant digits, and (5) exponent bias.

  2. Knowledge of Precision Farming Beneficiaries

    Directory of Open Access Journals (Sweden)

    A.V. Greena

    2016-05-01

    Full Text Available Precision Farming is one of the many advanced farming practices that make production more efficient by better resource management and reducing wastage. TN-IAMWARM is a world bank funded project aims to improve the farm productivity and income through better water management. The present study was carried out in Kambainallur sub basin of Dharmapuri district with 120 TN-IAMWARM beneficiaries as respondents. The result indicated that more than three fourth (76.67 % of the respondents had high level of knowledge on precision farming technologies which was made possible by the implementation of TN-IAMWARM project. The study further revealed that educational status, occupational status and exposure to agricultural messages had a positive and significant contribution to the knowledge level of the respondents at 0.01 level of probability whereas experience in precision farming and social participation had a positive and significant contribution at 0.05 level of probability.

  3. Aesthetic and biomechanical precision in complex cases.

    Science.gov (United States)

    Mizrahi, Basil

    2009-12-01

    The success of dental restorations should not only be measured by immediate outcomes, such as patient comfort and appearance, but also by long-term survival and stability of the definitive restorations. Long-term success is dependant on the level of precision at which treatment is carried out. The three main areas in which this precision should be focused are precision of fit, occiusal precision, and aesthetic precision.

  4. Precision radiometric surface temperature (PRST) sensor

    Science.gov (United States)

    Daly, James T.; Roberts, Carson; Bodkin, Andrew; Sundberg, Robert; Beaven, Scott; Weinheimer, Jeffrey

    2013-05-01

    There is a need for a Precision Radiometric Surface Temperature (PRST) measurement capability that can achieve noncontact profiling of a sample's surface temperature when heated dynamically during laser processing, aerothermal heating or metal cutting/machining. Target surface temperature maps within and near the heated spot provide critical quantitative diagnostic data for laser-target coupling effectiveness and laser damage assessment. In the case of metal cutting, this type of measurement provides information on plastic deformation in the primary shear zone where the cutting tool is in contact with the workpiece. The challenge in these cases is to measure the temperature of a target while its surface's temperature and emissivity are changing rapidly and with incomplete knowledge of how the emissivity and surface texture (scattering) changes with temperature. Bodkin Design and Engineering, LLC (BDandE), with partners Spectral Sciences, Inc. (SSI) and Space Computer Corporation (SCC), has developed a PRST Sensor that is based on a hyperspectral MWIR imager spanning the wavelength range 2-5 μm and providing a hyperspectral datacube of 20-24 wavelengths at 60 Hz frame rate or faster. This imager is integrated with software and algorithms to extract surface temperature from radiometric measurements over the range from ambient to 2000K with a precision of 20K, even without a priori knowledge of the target's emissivity and even as the target emissivity may be changing with time and temperature. In this paper, we will present a description of the PRST system as well as laser heating test results which show the PRST system mapping target surface temperatures in the range 600-2600K on a variety of materials.

  5. Precision luminosity measurement at ILC

    CERN Document Server

    AUTHOR|(CDS)2073074; Pandurovic, M; Smiljanic, I

    2013-01-01

    In these proceedings a novel approach to deal with the beam-induced effects in luminosity measurement is presented. Based on the relativistic kinematics of the collision frame of the Bhabha process, the beam-beam related uncertainties can be reduced to the permille level independently of a precision with which the beam parameters are known. Specific event selection combined with the corrective methods we introduce, leads to the systematic uncertainty from the beam-induced effects to be at a few permille level in the peak region above the 80% of the nominal centre-of-mass energies at ILC.

  6. Electroweak precision measurements in CMS

    CERN Document Server

    Dordevic, Milos

    2017-01-01

    An overview of recent results on electroweak precision measurements from the CMS Collaboration is presented. Studies of the weak boson differential transverse momentum spectra, Z boson angular coefficients, forward-backward asymmetry of Drell-Yan lepton pairs and charge asymmetry of W boson production are made in comparison to the state-of-the-art Monte Carlo generators and theoretical predictions. The results show a good agreement with the Standard Model. As a proof of principle for future W mass measurements, a W-like analysis of the Z boson mass is performed.

  7. Precision Light Flavor Physics from Lattice QCD

    Science.gov (United States)

    Murphy, David

    In this thesis we present three distinct contributions to the study of light flavor physics using the techniques of lattice QCD. These results are arranged into four self-contained papers. The first two papers concern global fits of the quark mass, lattice spacing, and finite volume dependence of the pseudoscalar meson masses and decay constants, computed in a series of lattice QCD simulations, to partially quenched SU(2) and SU(3) chiral perturbation theory (chiPT). These fits determine a subset of the low energy constants of chiral perturbation theory -- in some cases with increased precision, and in other cases for the first time -- which, once determined, can be used to compute other observables and amplitudes in chiPT. We also use our formalism to self-consistently probe the behavior of the (asymptotic) chiral expansion as a function of the quark masses by repeating the fits with different subsets of the data. The third paper concerns the first lattice QCD calculation of the semileptonic K0 → pi-l +nul ( Kl3) form factor at vanishing momentum transfer, f+Kpi(0), with physical mass domain wall quarks. The value of this form factor can be combined with a Standard Model analysis of the experimentally measured K0 → pi -l+nu l decay rate to extract a precise value of the Cabibbo-Kobayashi-Maskawa (CKM) matrix element Vus, and to test unitarity of the CKM matrix. We also discuss lattice calculations of the pion and kaon decay constants, which can be used to extract Vud through an analogous Standard Model analysis of experimental constraints on leptonic pion and kaon decays. The final paper explores the recently proposed exact one flavor algorithm (EOFA). This algorithm has been shown to drastically reduce the memory footprint required to simulate single quark flavors on the lattice relative to the widely used rational hybrid Monte Carlo (RHMC) algorithm, while also offering modest O(20%) speed-ups. We independently derive the exact one flavor action, explore its

  8. Precision Measurement in Quantum Optics

    Science.gov (United States)

    Starling, David J.

    The work contained in this thesis is derived from various projects completed during my studies at the University of Rochester. The first chapter introduces the reader to foundational concepts in quantum mechanics, quantum optics, weak values, and the interaction of light with matter. Chapter two covers the results of experiments conducted to measure the deflection of a beam of classical light using the weak value formalism. A discussion of the optimal signal to noise ratio of such a measurement is included. Chapter three shows how the so-called "inverse weak value" can be used to measure the phase of an optical beam with high precision. The following chapter includes results on precision frequency measurements using a standard glass prism and weak values, followed by related experimental results arising from the interaction of light with gaseous rubidium. Chapter five focuses on a proposal to use weak measurements to undo a random disturbance in the amplitude or phase of an entangled pair of photons. It is shown that the entanglement of an ensemble of photon pairs can be largely restored after this random disturbance.

  9. Precision luminosity measurements at LHCb

    CERN Document Server

    Aaij, Roel; Adinolfi, Marco; Affolder, Anthony; Ajaltouni, Ziad; Akar, Simon; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio Augusto; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Anderson, Jonathan; Andreassen, Rolf; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Baesso, Clarissa; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Battista, Vincenzo; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Belogurov, Sergey; Belous, Konstantin; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bien, Alexander; Bifani, Simone; Bird, Thomas; Bizzeti, Andrea; Bjørnstad, Pål Marius; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borghi, Silvia; Borgia, Alessandra; Borsato, Martino; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Brambach, Tobias; Bressieux, Joël; Brett, David; Britsch, Markward; Britton, Thomas; Brodzicka, Jolanta; Brook, Nicholas; Brown, Henry; Bursche, Albert; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Calvi, Marta; Calvo Gomez, Miriam; Campana, Pierluigi; Campora Perez, Daniel; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Chefdeville, Maximilien; Chen, Shanzhen; Cheung, Shu-Faye; Chiapolini, Nicola; Chrzaszcz, Marcin; Ciba, Krzystof; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coco, Victor; Cogan, Julien; Cogneras, Eric; Cojocariu, Lucian; Collazuol, Gianmaria; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Counts, Ian; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dalseno, Jeremy; David, Pascal; David, Pieter; Davis, Adam; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Silva, Weeraddana; De Simone, Patrizia; Dean, Cameron Thomas; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Di Canto, Angelo; Dijkstra, Hans; Donleavy, Stephanie; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dossett, David; Dovbnya, Anatoliy; Dreimanis, Karlis; Dujany, Giulio; Dupertuis, Frederic; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Ely, Scott; Esen, Sevda; Evans, Hannah Mary; Evans, Timothy; Falabella, Antonio; Färber, Christian; Farinelli, Chiara; Farley, Nathanael; Farry, Stephen; Fay, Robert; Ferguson, Dianne; Fernandez Albor, Victor; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fol, Philip; Fontana, Marianna; Fontanelli, Flavio; Forty, Roger; Francisco, Oscar; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Fu, Jinlin; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; García Pardiñas, Julián; Garofoli, Justin; Garra Tico, Jordi; Garrido, Lluis; Gascon, David; Gaspar, Clara; Gauld, Rhorry; Gavardi, Laura; Geraci, Angelo; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianelle, Alessio; Gianì, Sebastiana; Gibson, Valerie; Giubega, Lavinia-Helena; Gligorov, V.V.; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gotti, Claudio; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graziani, Giacomo; Grecu, Alexandru; Greening, Edward; Gregson, Sam; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hall, Samuel; Hamilton, Brian; Hampson, Thomas; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; He, Jibo; Head, Timothy; Heijne, Veerle; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hulsbergen, Wouter; Hunt, Philip; Hussain, Nazim; Hutchcroft, David; Hynds, Daniel; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jalocha, Pawel; Jans, Eddy; Jaton, Pierre; Jawahery, Abolhassan; Jing, Fanfan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Karbach, Moritz; Karodia, Sarah; Kelsey, Matthew; Kenyon, Ian; Ketel, Tjeerd; Khanji, Basem; Khurewathanakul, Chitsanu; Klaver, Suzanne; Klimaszewski, Konrad; Kochebina, Olga; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Korolev, Mikhail; Kozlinskiy, Alexandr; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krocker, Georg; Krokovny, Pavel; Kruse, Florian; Kucewicz, Wojciech; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kurek, Krzysztof; Kvaratskheliya, Tengiz; La Thi, Viet Nga; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lambert, Robert W; Lanfranchi, Gaia; Langenbruch, Christoph; Langhans, Benedikt; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Leo, Sabato; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Likhomanenko, Tatiana; Liles, Myfanwy; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Lohn, Stefan; Longstaff, Iain; Lopes, Jose; Lopez-March, Neus; Lowdon, Peter; Lu, Haiting; Lucchesi, Donatella; Luo, Haofei; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Machefert, Frederic; Machikhiliyan, Irina V; Maciuc, Florin; Maev, Oleg; Malde, Sneha; Malinin, Alexander; Manca, Giulia; Mancinelli, Giampiero; Mapelli, Alessandro; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marino, Pietro; Märki, Raphael; Marks, Jörg; Martellotti, Giuseppe; Martens, Aurelien; Martín Sánchez, Alexandra; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massafferri, André; Matev, Rosen; Mathe, Zoltan; Matteuzzi, Clara; Maurin, Brice; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; McSkelly, Ben; Meadows, Brian; Meier, Frank; Meissner, Marco; Merk, Marcel; Milanes, Diego Alejandro; Minard, Marie-Noelle; Moggi, Niccolò; Molina Rodriguez, Josue; Monteil, Stephane; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Morris, Adam Benjamin; Mountain, Raymond; Muheim, Franz; Müller, Katharina; Mussini, Manuel; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen, Thi-Dung; Nguyen-Mau, Chung; Nicol, Michelle; Niess, Valentin; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Novoselov, Alexey; O'Hanlon, Daniel Patrick; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Oggero, Serena; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Orlandea, Marius; Otalora Goicochea, Juan Martin; Owen, Patrick; Oyanguren, Maria Arantza; Pal, Bilas Kanti; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Parkes, Christopher; Parkinson, Christopher John; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pearce, Alex; Pellegrino, Antonio; Pepe Altarelli, Monica; Perazzini, Stefano; Perret, Pascal; Perrin-Terrin, Mathieu; Pescatore, Luca; Pesen, Erhan; Pessina, Gianluigi; Petridis, Konstantin; Petrolini, Alessandro; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pilař, Tomas; Pinci, Davide; Pistone, Alessandro; Playfer, Stephen; Plo Casasus, Maximo; Polci, Francesco; Poluektov, Anton; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Price, Eugenia; Price, Joseph David; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Rachwal, Bartolomiej; Rademacker, Jonas; Rakotomiaramanana, Barinjaka; Rama, Matteo; Rangel, Murilo; Raniuk, Iurii; Rauschmayr, Nathalie; Raven, Gerhard; Redi, Federico; Reichert, Stefanie; Reid, Matthew; dos Reis, Alberto; Ricciardi, Stefania; Richards, Sophie; Rihl, Mariana; Rinnert, Kurt; Rives Molina, Vincente; Robbe, Patrick; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Perez, Pablo; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Rotondo, Marcello; Rouvinet, Julien; Ruf, Thomas; Ruiz, Hugo; Ruiz Valls, Pablo; Saborido Silva, Juan Jose; Sagidova, Naylya; Sail, Paul; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santovetti, Emanuele; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Saunders, Daniel Martin; Savrina, Darya; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schubiger, Maxime; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Semennikov, Alexander; Sepp, Indrek; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Shires, Alexander; Silva Coutinho, Rafael; Simi, Gabriele; Sirendi, Marek; Skidmore, Nicola; Skwarnicki, Tomasz; Smith, Anthony; Smith, Edmund; Smith, Eluned; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Sparkes, Ailsa; Spradlin, Patrick; Sridharan, Srikanth; Stagni, Federico; Stahl, Marian; Stahl, Sascha; Steinkamp, Olaf; Stenyakin, Oleg; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Stroili, Roberto; Subbiah, Vijay Kartik; Sun, Liang; Sutcliffe, William; Swientek, Krzysztof; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szczypka, Paul; Szumlak, Tomasz; T'Jampens, Stephane; Teklishyn, Maksym; Tellarini, Giulia; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Torr, Nicholas; Tournefier, Edwige; Tourneur, Stephane; Tran, Minh Tâm; Tresch, Marco; Trisovic, Ana; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ubeda Garcia, Mario; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vacca, Claudia; Vagnoni, Vincenzo; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vieites Diaz, Maria; Vilasis-Cardona, Xavier; Vollhardt, Achim; Volyanskyy, Dmytro; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Walsh, John; Wandernoth, Sebastian; Wang, Jianchun; Ward, David; Watson, Nigel; Websdale, David; Whitehead, Mark; Wicht, Jean; Wiedner, Dirk; Wilkinson, Guy; Williams, Matthew; Williams, Mike; Wilschut, Hans; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wright, Simon; Wyllie, Kenneth; Xie, Yuehong; Xing, Zhou; Xu, Zhirui; Yang, Zhenwei; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Liming; Zhang, Wen Chao; Zhang, Yanxi; Zhelezov, Alexey; Zhokhov, Anatoly; Zhong, Liang; Zvyagin, Alexander

    2014-12-05

    Measuring cross-sections at the LHC requires the luminosity to be determined accurately at each centre-of-mass energy $\\sqrt{s}$. In this paper results are reported from the luminosity calibrations carried out at the LHC interaction point 8 with the LHCb detector for $\\sqrt{s}$ = 2.76, 7 and 8 TeV (proton-proton collisions) and for $\\sqrt{s_{NN}}$ = 5 TeV (proton-lead collisions). Both the "van der Meer scan" and "beam-gas imaging" luminosity calibration methods were employed. It is observed that the beam density profile cannot always be described by a function that is factorizable in the two transverse coordinates. The introduction of a two-dimensional description of the beams improves significantly the consistency of the results. For proton-proton interactions at $\\sqrt{s}$ = 8 TeV a relative precision of the luminosity calibration of 1.47% is obtained using van der Meer scans and 1.43% using beam-gas imaging, resulting in a combined precision of 1.12%. Applying the calibration to the full data set determin...

  10. Precision metrology using weak measurements.

    Science.gov (United States)

    Zhang, Lijian; Datta, Animesh; Walmsley, Ian A

    2015-05-29

    Weak values and measurements have been proposed as a means to achieve dramatic enhancements in metrology based on the greatly increased range of possible measurement outcomes. Unfortunately, the very large values of measurement outcomes occur with highly suppressed probabilities. This raises three vital questions in weak-measurement-based metrology. Namely, (Q1) Does postselection enhance the measurement precision? (Q2) Does weak measurement offer better precision than strong measurement? (Q3) Is it possible to beat the standard quantum limit or to achieve the Heisenberg limit with weak measurement using only classical resources? We analyze these questions for two prototypical, and generic, measurement protocols and show that while the answers to the first two questions are negative for both protocols, the answer to the last is affirmative for measurements with phase-space interactions, and negative for configuration space interactions. Our results, particularly the ability of weak measurements to perform at par with strong measurements in some cases, are instructive for the design of weak-measurement-based protocols for quantum metrology.

  11. Polyaromatic disordered carbon grains as carriers of the UV bump: Far-UV to mid-IR spectroscopy of laboratory analogs

    Science.gov (United States)

    Gavilan, L.; Le, K. C.; Pino, T.; Alata, I.; Giuliani, A.; Dartois, E.

    2017-11-01

    Context. A multiwavelength study of laboratory carbons with varying degrees of hydrogenation and sp2 hybridization is required to characterize the structure of the carbonaceous carriers of interstellar and circumstellar extinction. Aims: We study the spectral properties of carbonaceous dust analogs from the far-ultraviolet to the mid-infrared and correlate features in both spectral ranges to the aromatic/aliphatic degree. Methods: Analogs to carbonaceous interstellar dust encountered in various phases of the interstellar medium have been prepared in the laboratory. These are amorphous hydrogenated carbons (a-C:H), analogs to the diffuse interstellar medium component, and soot particles, analogs to the polyaromatic component. Thin films (d beam line at the SOLEIL synchrotron radiation facility. Spectra of these films were further measured through the UV-Vis (210 nm-1 μm) and in the mid-infrared (3-15 μm). Results: Tauc optical gaps, Eg, are derived from the visible spectra. The major spectral features are fitted through the VUV to the mid-infrared to obtain positions, full-widths at half maximum (FWHM), and integrated intensities. These are plotted against the position of the π-π∗ electronic transitions peak. Unidentified or overlapping features in the UV are identified by correlations with complementary infrared data. A correlation between the optical gap and position of the π-π∗ electronic transitions peak is found. The latter is also correlated to the position of the sp3 carbon defect band at 8 μm, the aromatic C=C stretching mode position at 6 μm, and the H/C ratio. Conclusions: Ultraviolet and infrared spectroscopy of structurally diverse carbon samples are used to constrain the nanostructural properties of carbon carriers of both circumstellar and interstellar extinction, such as the associated coherent lengths and the size of polyaromatic units. Our study suggests that carriers of the interstellar UV bump should exhibit infrared bands akin to the

  12. Light Microscopy at Maximal Precision

    Science.gov (United States)

    Bierbaum, Matthew; Leahy, Brian D.; Alemi, Alexander A.; Cohen, Itai; Sethna, James P.

    2017-10-01

    Microscopy is the workhorse of the physical and life sciences, producing crisp images of everything from atoms to cells well beyond the capabilities of the human eye. However, the analysis of these images is frequently little more accurate than manual marking. Here, we revolutionize the analysis of microscopy images, extracting all the useful information theoretically contained in a complex microscope image. Using a generic, methodological approach, we extract the information by fitting experimental images with a detailed optical model of the microscope, a method we call parameter extraction from reconstructing images (PERI). As a proof of principle, we demonstrate this approach with a confocal image of colloidal spheres, improving measurements of particle positions and radii by 10-100 times over current methods and attaining the maximum possible accuracy. With this unprecedented accuracy, we measure nanometer-scale colloidal interactions in dense suspensions solely with light microscopy, a previously impossible feat. Our approach is generic and applicable to imaging methods from brightfield to electron microscopy, where we expect accuracies of 1 nm and 0.1 pm, respectively.

  13. Precision cosmology and the landscape

    Energy Technology Data Exchange (ETDEWEB)

    Bousso, Raphael; Bousso, Raphael

    2006-10-01

    After reviewing the cosmological constant problem -- why is Lambda not huge? -- I outline the two basic approaches that had emerged by the late 1980s, and note that each made a clear prediction. Precision cosmological experiments now indicate that the cosmological constant is nonzero. This result strongly favors the environmental approach, in which vacuum energy can vary discretely among widely separated regions in the universe. The need to explain this variation from first principles constitutes an observational constraint on fundamental theory. I review arguments that string theory satisfies this constraint, as it contains a dense discretuum of metastable vacua. The enormous landscape of vacua calls for novel, statistical methods of deriving predictions, and it prompts us to reexamine our description of spacetime on the largest scales. I discuss the effects of cosmological dynamics, and I speculate that weighting vacua by their entropy production may allow for prior-free predictions that do not resort to explicitly anthropic arguments.

  14. Precise Nanoelectronics with Adatom Chains

    Science.gov (United States)

    Yamada, Toshishige

    1999-01-01

    Adatom chains on an atomically regulated substrate will be building components in future precise nanoelectronics. Adatoms need to be secured with chemical bonding, but then electronic isolation between the adatom and substrate systems is not guaranteed. A one-dimensional model shows that good isolation with existence of surface states is expected on an s-p crossing substrate such as Si, Ge, or GaAs, reflecting the bulk nature of the substrate. Isolation is better if adatoms are electronically similar to the substrate atoms, and can be manipulated by hydrogenation. Chain structures with group IV adatoms with two chemical bonds, or group III adatoms with one chemical bond, are semiconducting, reflecting the surface nature of the substrate. These structures are unintentionally doped due to the charge transfer across the chemical bonds. Physical properties of adatom chains have to be determined for the unified adatom-substrate system.

  15. GPS Precision Timing at CERN

    CERN Document Server

    Beetham, C G

    1999-01-01

    For the past decade, the Global Positioning System (GPS) has been used to provide precise time, frequency and position co-ordinates world-wide. Recently, equipment has become available specialising in providing extremely accurate timing information, referenced to Universal Time Co-ordinates (UTC). This feature has been used at CERN to provide time of day information for systems that have been installed in the Proton Synchrotron (PS), Super Proton Synchrotron (SPS) and the Large Electron Positron (LEP) machines. The different systems are described as well as the planned developments, particularly with respect to optical transmission and the Inter-Range Instrumentation Group IRIG-B standard, for future use in the Large Hadron Collider (LHC).

  16. Precise α from τ Decays

    Science.gov (United States)

    Malaescu, B.

    2009-01-01

    An updated measurement of α(mτ2) from ALEPH τ hadronic spectral functions is presented. We report a study of the perturbative prediction(s) showing that the fixed-order perturbation theory manifests convergence or principle problems not presented in the contour-improved calculation. Potential systematic effects from quark-hadron duality violations are estimated to be within the quoted systematic errors. The fit result is α(mτ2)=0.344±0.005±0.007, where the first error is experimental and the second theoretical. After evolution, the α(mZ2) determined from τ data is one of the most precise to date, in agreement with the corresponding NLO value derived from Z decays.

  17. Precision moisture generation and measurement.

    Energy Technology Data Exchange (ETDEWEB)

    Thornberg, Steven Michael; White, Michael I.; Irwin, Adriane Nadine

    2010-03-01

    In many industrial processes, gaseous moisture is undesirable as it can lead to metal corrosion, polymer degradation, and other materials aging processes. However, generating and measuring precise moisture concentrations is challenging due to the need to cover a broad concentration range (parts-per-billion to percent) and the affinity of moisture to a wide range surfaces and materials. This document will discuss the techniques employed by the Mass Spectrometry Laboratory of the Materials Reliability Department at Sandia National Laboratories to generate and measure known gaseous moisture concentrations. This document highlights the use of a chilled mirror and primary standard humidity generator for the characterization of aluminum oxide moisture sensors. The data presented shows an excellent correlation in frost point measured between the two instruments, and thus provides an accurate and reliable platform for characterizing moisture sensors and performing other moisture related experiments.

  18. Role of telecommunications in precision agriculture

    Science.gov (United States)

    Precision agriculture has been made possible by the confluence of several technologies: geographic positioning systems, geographic information systems, image analysis software, low-cost microcomputer-based variable rate controller/recorders, and precision tractor guidance systems. While these techn...

  19. Precision Electrospray Thruster Assembly (PETA) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — New low cost, low volume, low power, rugged electrospray thrusters will be ideal as actuators for precision thrusting, if provided with precision high voltage power...

  20. Ultrasonic precision optical grinding technology

    Science.gov (United States)

    Cahill, Michael J.; Bechtold, Michael J.; Fess, Edward; Wolfs, Frank L.; Bechtold, Rob

    2015-10-01

    As optical geometries become more precise and complex and a wider range of materials are used, the processes used for manufacturing become more critical. As the preparatory stage for polishing, this is especially true for grinding. Slow processing speeds, accelerated tool wear, and poor surface quality are often detriments in manufacturing glass and hard ceramics. The quality of the ground surface greatly influences the polishing process and the resulting finished product. Through extensive research and development, OptiPro Systems has introduced an ultrasonic assisted grinding technology, OptiSonic, which has numerous advantages over traditional grinding processes. OptiSonic utilizes a custom tool holder designed to produce oscillations in line with the rotating spindle. A newly developed software package called IntelliSonic is integral to this platform. IntelliSonic automatically characterizes the tool and continuously optimizes the output frequency for optimal cutting while in contact with the part. This helps maintain a highly consistent process under changing load conditions for a more accurate surface. Utilizing a wide variety of instruments, test have proven to show a reduction in tool wear and increase in surface quality while allowing processing speeds to be increased. OptiSonic has proven to be an enabling technology to overcome the difficulties seen in grinding of glass and hard optical ceramics. OptiSonic has demonstrated numerous advantages over the standard CNC grinding process. Advantages are evident in reduced tool wear, better surface quality, and reduced cycle times due to increased feed rates. These benefits can be seen over numerous applications within the precision optics industry.

  1. (DGPS) to harvesting date and precision viticulture

    African Journals Online (AJOL)

    hope&shola

    2010-11-29

    Nov 29, 2010 ... Tysseyre B, Ardoin N, Sevilla F (1999). Precise viticulture: precise location and vigour mapping aspects. Papers presented at the 2nd. European Conference on Precision Agriculture, Odense, Denmark,. 11-15 July 1999. Sheffiled Academic Press, Sheffield, UK, pp. 319-. 330. Zufferey V, Murisier F (1997).

  2. Precision production: enabling deterministic throughput for precision aspheres with MRF

    Science.gov (United States)

    Maloney, Chris; Entezarian, Navid; Dumas, Paul

    2017-10-01

    Aspherical lenses offer advantages over spherical optics by improving image quality or reducing the number of elements necessary in an optical system. Aspheres are no longer being used exclusively by high-end optical systems but are now replacing spherical optics in many applications. The need for a method of production-manufacturing of precision aspheres has emerged and is part of the reason that the optics industry is shifting away from artisan-based techniques towards more deterministic methods. Not only does Magnetorheological Finishing (MRF) empower deterministic figure correction for the most demanding aspheres but it also enables deterministic and efficient throughput for series production of aspheres. The Q-flex MRF platform is designed to support batch production in a simple and user friendly manner. Thorlabs routinely utilizes the advancements of this platform and has provided results from using MRF to finish a batch of aspheres as a case study. We have developed an analysis notebook to evaluate necessary specifications for implementing quality control metrics. MRF brings confidence to optical manufacturing by ensuring high throughput for batch processing of aspheres.

  3. Precision measurements with atom interferometry

    Science.gov (United States)

    Schubert, Christian; Abend, Sven; Schlippert, Dennis; Ertmer, Wolfgang; Rasel, Ernst M.

    2017-04-01

    Interferometry with matter waves enables precise measurements of rotations, accelerations, and differential accelerations [1-5]. This is exploited for determining fundamental constants [2], in fundamental science as e.g. testing the universality of free fall [3], and is applied for gravimetry [4], and gravity gradiometry [2,5]. At the Institut für Quantenoptik in Hannover, different approaches are pursued. A large scale device is designed and currently being set up to investigate the gain in precision for gravimetry, gradiometry, and fundamental tests on large baselines [6]. For field applications, a compact and transportable device is being developed. Its key feature is an atom chip source providing a collimated high flux of atoms which is expected to mitigate systematic uncertainties [7,8]. The atom chip technology and miniaturization benefits from microgravity experiments in the drop tower in Bremen and sounding rocket experiments [8,9] which act as pathfinders for space borne operation [10]. This contribution will report about our recent results. The presented work is supported by the CRC 1227 DQ-mat, the CRC 1128 geo-Q, the RTG 1729, the QUEST-LFS, and by the German Space Agency (DLR) with funds provided by the Federal Ministry of Economic Affairs and Energy (BMWi) due to an enactment of the German Bundestag under Grant No. DLR 50WM1552-1557. [1] P. Berg et al., Phys. Rev. Lett., 114, 063002, 2015; I. Dutta et al., Phys. Rev. Lett., 116, 183003, 2016. [2] J. B. Fixler et al., Science 315, 74 (2007); G. Rosi et al., Nature 510, 518, 2014. [3] D. Schlippert et al., Phys. Rev. Lett., 112, 203002, 2014. [4] A. Peters et al., Nature 400, 849, 1999; A. Louchet-Chauvet et al., New J. Phys. 13, 065026, 2011; C. Freier et al., J. of Phys.: Conf. Series 723, 012050, 2016. [5] J. M. McGuirk et al., Phys. Rev. A 65, 033608, 2002; P. Asenbaum et al., arXiv:1610.03832. [6] J. Hartwig et al., New J. Phys. 17, 035011, 2015. [7] H. Ahlers et al., Phys. Rev. Lett. 116, 173601

  4. Studying antimatter with laser precision

    CERN Document Server

    Katarina Anthony

    2012-01-01

    The next generation of antihydrogen trapping devices, ALPHA-2, is moving into CERN’s Antiproton Decelerator (AD) hall. This brand-new experiment will allow the ALPHA collaboration to conduct studies of antimatter with greater precision. ALPHA spokesperson Jeffrey Hangst was recently awarded a grant by the Carlsberg Foundation, which will be used to purchase equipment for the new experiment.   A 3-D view of the new magnet (in blue) and cryostat. The red lines show the paths of laser beams. LHC-type current leads for the superconducting magnets are visible on the top-right of the image. The ALPHA collaboration has been working to trap and study antihydrogen since 2006. Using antiprotons provided by CERN’s Antiproton Decelerator (AD), ALPHA was the first experiment to trap antihydrogen and to hold it long enough to study its properties. “The new ALPHA-2 experiment will use integrated lasers to probe the trapped antihydrogen,” explains Jeffrey Hangst, ALP...

  5. The Age of Precision Cosmology

    Science.gov (United States)

    Chuss, David T.

    2012-01-01

    In the past two decades, our understanding of the evolution and fate of the universe has increased dramatically. This "Age of Precision Cosmology" has been ushered in by measurements that have both elucidated the details of the Big Bang cosmology and set the direction for future lines of inquiry. Our universe appears to consist of 5% baryonic matter; 23% of the universe's energy content is dark matter which is responsible for the observed structure in the universe; and 72% of the energy density is so-called "dark energy" that is currently accelerating the expansion of the universe. In addition, our universe has been measured to be geometrically flat to 1 %. These observations and related details of the Big Bang paradigm have hinted that the universe underwent an epoch of accelerated expansion known as Uinflation" early in its history. In this talk, I will review the highlights of modern cosmology, focusing on the contributions made by measurements of the cosmic microwave background, the faint afterglow of the Big Bang. I will also describe new instruments designed to measure the polarization of the cosmic microwave background in order to search for evidence of cosmic inflation.

  6. Precision is in their nature

    CERN Multimedia

    Antonella Del Rosso

    2014-01-01

    There are more than 100 of them in the LHC ring and they have a total of about 400 degrees of freedom. Each one has 4 motors and the newest ones have their own beam-monitoring pickups. Their jaws constrain the relativistic, high-energy particles to a very small transverse area and protect the machine aperture. We are speaking about the LHC collimators, those ultra-precise instruments that leave escaping unstable particles no chance.   The internal structure of a new LHC collimator featuring (see red arrow) one of the beam position monitor's pickups. Designed at CERN but mostly produced by very specialised manufacturers in Europe, the LHC collimators are among the most complex elements of the accelerator. Their job is to control and safely dispose of the halo particles that are produced by unavoidable beam losses from the circulating beam core. “The LHC collimation system has been designed to ensure that beam losses in superconducting magnets remain below quench limits in al...

  7. Personalized and precision orthodontic therapy.

    Science.gov (United States)

    Iwasaki, L R; Covell, D A; Frazier-Bowers, S A; Kapila, S; Huja, S S; Nickel, J C

    2015-04-01

    To bring together orthodontic stakeholders from academics, industry, and private practice for a series of thematically focused workshops to explore and develop the transfer of novel approaches into clinical orthodontic practice. Twenty-seven invited speakers, eight poster presenters, and participants of the Consortium for Orthodontic Advances in Science and Technology (COAST) 2014 Innovators' Workshop at the Eaglewood Resort and Spa, Itasca, Illinois, September 11-14, 2014. Five themed sessions involving between 4-7 presentations followed by panel discussions were organized. The aims of the discussion sessions were to highlight important findings and consider the strength of evidence for these, indicate next steps and needed research or technological developments to move forward, and to weigh the expected benefits from these findings and steps to implement in clinical practice. Among important areas for attention identified were need for multiscale and multispecies modeling and experimentation for interspecies translation of results; large-scale collaborative efforts within the profession to address the need for adequate sample sizes for future genetic studies of complex traits such as malocclusion; a consortium approach to improve new technologies such as intra-oral scanning and 3D imaging by establishing standards; and harnessing the growing body of knowledge about bone biology for application in orthodontics. With increased awareness of the potential of current and emerging technologies, translation of personalized and precision approaches in the field of orthodontics holds ever-increasing promise. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  8. PRECISION TIME-DELAY GENERATOR

    Science.gov (United States)

    Carr, B.J.; Peckham, V.D.

    1959-06-16

    A precision time-delay generator circuit with low jitter is described. The first thyratron has a series resonant circuit and a diode which is connected to the second thyratron. The first thyratron is triggered at the begin-ning of a time delay and a capacitor is discharged through the first thyratron and the diode, thereby, triggering the second thyratron. (T.R.H.) l6l9O The instrument described can measure pressures between sea level and 300,000 ft. The pressure- sensing transducer of the instrument is a small cylindrical tube with a thin foil of titanium-tritium fastened around the inside of the tube. Output is a digital signal which can be used for storage or telemetering more conveniently than an analog signal. (W.D.M.) l6l9l An experimental study was made on rolling contacts in the temperature range of 550 to 1000 deg F. Variables such as material composition, hardness, and operating conditions were investigated in a rolling test stand. Ball bearing tests were run to determine the effect of design parameters, bearing materials, lubricants, and operating conditions. (auth)

  9. TT40 Damage during 2004 High Intensity SPS Extraction

    CERN Document Server

    Goddard, B; Mertens, V; Uythoven, J; Wenninger, J; CERN. Geneva. AB Department

    2005-01-01

    During high intensity extraction on 25/10/04 an incident occurred in which the vacuum chamber of the TT40 magnet QTRF4002 was badly damaged. The beam was a 450 GeV full LHC injection batch of 3.4 1013 p+ in 288 bunches, and was extracted from SPS LSS4 with the wrong trajectory. Prior to the fatal extraction, problems had occurred over several hours during the setting-up, with beam-induced noise causing the extraction septum interlock to trip the power convertor, and also with the bumped beam position interlock. Deficiencies in the extraction setting-up process, in the interlocking and in the operational procedures used for the high-intensity test were contributing factors. In this note the incident causes are identified, the details reconstructed from the logged data, and the damage to the vacuum chamber analysed. The remedial measures which have already been taken are explained, and further recommendations made concerning the interlocking system performance and tests, as well as the operational procedures wh...

  10. Study of Abnormal Vertical Emittance Growth in ATF Extraction Line

    Energy Technology Data Exchange (ETDEWEB)

    Alabau, M.; Faus-Golfe, A.; /Valencia U., IFIC; Alabau, M.; Bambade, P.; Brossard, J.; Le Meur, G.; Rimbault, C.; Touze, F.; /Orsay, LAL; Angal-Kalinin, D.; Jones, J.K.; /Daresbury; Appleby, R.; Scarfe, A.; /Manchester U.; Kuroda, S.; /KEK, Tsukuba; White, G.R.; Woodley, M.; /SLAC; Zimmermann, F.; /CERN

    2011-11-04

    Since several years, the vertical beam emittance measured in the Extraction Line (EXT) of the Accelerator Test Facility (ATF) at KEK, that will transport the electron beam from the ATF Damping Ring (DR) to the future ATF2 Final Focus beam line, is significantly larger than the emittance measured in the DR itself, and there are indications that it grows rapidly with increasing beam intensity. This longstanding problem has motivated studies of possible sources of this anomalous emittance growth. One possible contribution is non-linear magnetic fields in the extraction region experimented by the beam while passing off-axis through magnets of the DR during the extraction process. In this paper, simulations of the emittance growth are presented and compared to observations. These simulations include the effects of predicted non-linear field errors in the shared DR magnets and orbit displacements from the reference orbit in the extraction region. Results of recent measurements using closed orbit bumps to probe the relation between the extraction trajectory and the anomalous emittance growth are also presented.

  11. Precise Analysis of String Expressions

    DEFF Research Database (Denmark)

    Christensen, Aske Simon; Møller, Anders; Schwartzbach, Michael Ignatieff

    2003-01-01

    We perform static analysis of Java programs to answer a simple question: which values may occur as results of string expressions? The answers are summarized for each expression by a regular language that is guaranteed to contain all possible values. We present several applications of this analysis......, including statically checking the syntax of dynamically generated expressions, such as SQL queries. Our analysis constructs flow graphs from class files and generates a context-free grammar with a nonterminal for each string expression. The language of this grammar is then widened into a regular language...... through a variant of an algorithm previously used for speech recognition. The collection of resulting regular languages is compactly represented as a special kind of multi-level automaton from which individual answers may be extracted. If a program error is detected, examples of invalid strings...

  12. Precision probes of QCD at high energies

    Science.gov (United States)

    Alioli, Simone; Farina, Marco; Pappadopulo, Duccio; Ruderman, Joshua T.

    2017-07-01

    New physics, that is too heavy to be produced directly, can leave measurable imprints on the tails of kinematic distributions at the LHC. We use energetic QCD processes to perform novel measurements of the Standard Model (SM) Effective Field Theory. We show that the dijet invariant mass spectrum, and the inclusive jet transverse momentum spectrum, are sensitive to a dimension 6 operator that modifies the gluon propagator at high energies. The dominant effect is constructive or destructive interference with SM jet production. We compare differential next-to-leading order predictions from POWHEG to public 7 TeV jet data, including scale, PDF, and experimental uncertainties and their respective correlations. We constrain a New Physics (NP) scale of 3.5 TeV with current data. We project the reach of future 13 and 100 TeV measurements, which we estimate to be sensitive to NP scales of 8 and 60 TeV, respectively. As an application, we apply our bounds to constrain heavy vector octet colorons that couple to the QCD current. We project that effective operators will surpass bump hunts, in terms of coloron mass reach, even for sequential couplings.

  13. Precision Study of the $\\beta$-decay of $^{62}$Ga

    CERN Multimedia

    2002-01-01

    It is proposed to perform a precision study of the $\\beta$-decay of $\\,^{62}$Ga taking advantage of recent developments of the ISOLDE Laser Ion Source. The goal is to eventually extend the high-precision knowledge of superallowed $\\beta$-decays beyond the nine decays that presently are used for extracting the V$_{ud}$ quark mixing matrix element of the CKM matrix. The scientific motivations are the current deviation of more than 2$\\sigma$ of the unitary condition of this matrix, which could be an indication of non-standard-model physics, and a test of the theoretical corrections applied to the experimental data. The experiment will utilise the Total Absorption $\\gamma$-ray (TAG) spectrometer in order to determine weak branchings to excited states in $^{62}$Zn and the ISOLDE spectroscopy station to perform half-life measurements and detailed spectroscopy of this nucleus.

  14. Implementing and Characterizing Precise Multiqubit Measurements

    Directory of Open Access Journals (Sweden)

    J. Z. Blumoff

    2016-09-01

    Full Text Available There are two general requirements to harness the computational power of quantum mechanics: the ability to manipulate the evolution of an isolated system and the ability to faithfully extract information from it. Quantum error correction and simulation often make a more exacting demand: the ability to perform nondestructive measurements of specific correlations within that system. We realize such measurements by employing a protocol adapted from Nigg and Girvin [Phys. Rev. Lett. 110, 243604 (2013], enabling real-time selection of arbitrary register-wide Pauli operators. Our implementation consists of a simple circuit quantum electrodynamics module of four highly coherent 3D transmon qubits, collectively coupled to a high-Q superconducting microwave cavity. As a demonstration, we enact all seven nontrivial subset-parity measurements on our three-qubit register. For each, we fully characterize the realized measurement by analyzing the detector (observable operators via quantum detector tomography and by analyzing the quantum backaction via conditioned process tomography. No single quantity completely encapsulates the performance of a measurement, and standard figures of merit have not yet emerged. Accordingly, we consider several new fidelity measures for both the detector and the complete measurement process. We measure all of these quantities and report high fidelities, indicating that we are measuring the desired quantities precisely and that the measurements are highly nondemolition. We further show that both results are improved significantly by an additional error-heralding measurement. The analyses we present here form a useful basis for the future characterization and validation of quantum measurements, anticipating the demands of emerging quantum technologies.

  15. Pursuit of Precision in the Field Artillery

    Science.gov (United States)

    2010-05-21

    artillery would satisfy the commander’s requirement for a precision standoff tactical weapon. The Copperhead was the U.S. Army’s attempt to make a 155...mm anti- tank artillery shell. Even though forward observers could use the Copperhead to engage specific targets on the battlefield, the line of...destroying Soviet tanks culminated in five separate and distinct precision munitions. The copperhead had true precision due to its laser seeker head

  16. Modeling and control of precision actuators

    CERN Document Server

    Kiong, Tan Kok

    2013-01-01

    IntroductionGrowing Interest in Precise ActuatorsTypes of Precise ActuatorsApplications of Precise ActuatorsNonlinear Dynamics and ModelingHysteresisCreepFrictionForce RipplesIdentification and Compensation of Preisach Hysteresis in Piezoelectric ActuatorsSVD-Based Identification and Compensation of Preisach HysteresisHigh-Bandwidth Identification and Compensation of Hysteretic Dynamics in Piezoelectric ActuatorsConcluding RemarksIdentification and Compensation of Frict

  17. Transonic Stability and Control Investigation of a 1/80-Scale Model of the Consolidated Vultee Skate 9 Seaplane, TED No. NACA DE 345: Transonic-Bump Method

    Science.gov (United States)

    Riebe, John M.; MacLeod, Richard G.

    1950-01-01

    An investigation of the longitudinal stability and of the all-movable horizontal tail and aileron control of a 1/80-scale reflection-plane model of the Consolidated Vultee Skate 9 seaplane has been made through a Mach number range of 0.6 to 1.16 on the transonic bump of the Langley high-speed 7- by 10-foot tunnel. At moderate lift coefficients (0.4 to 0.8) and below a Mach number of 1.0 the model was statically unstable longitudinally. The static longitudinal stability of the model at low lift coefficients increased with Mach number corresponding to a shift in aerodynamic center from 37 percent mean aerodynamic chord at a Mach number of 0.60 to 64 percent at a Mach number of 1.10. Estimates indicate that the tail deflection angle required for steady flight and for accelerated maneuvers of the Skate 9 airplane would probably not vary greatly with Mach number at sea level, but for accelerated maneuvers at altitude the tail deflection angle would probably vary erratically with Mach number. The variation of rolling-moment coefficient with aileron deflection angle was approximately linear, agreed well with theory, and held for the range of aileron deflections tested (-17.1 deg to 16.6 deg). At low lift coefficients the drag rise occurred at Mach numbers of 0.95 and 0.90 for the wing alone and the complete model, respectively. The effects of the canopy on the model were small. For the ranges investigated, angle-of-attack and Mach number changes caused no large pressure drops in the jet-engine duct.

  18. A single mutation in the gatekeeper residue in TgMAPKL-1 restores the inhibitory effect of a bumped kinase inhibitor on the cell cycle

    Directory of Open Access Journals (Sweden)

    Tatsuki Sugi

    2015-04-01

    Full Text Available Toxoplasma gondii is the causative pathogen for Toxoplasmosis. Bumped kinase inhibitor 1NM-PP1 inhibits the growth of T. gondii by targeting TgCDPK1. However, we recently reported that resistance to 1NM-PP1 can be acquired via a mutation in T. gondii mitogen-activated protein kinase like 1 (TgMAPKL-1. Further characterization of how this TgMAPKL-1 mutation restores the inhibitory effect of 1NM-PP1 would shed further light on the function of TgMAPKL-1 in the parasite life cycle. Therefore, we made parasite clones with TgMAPKL-1 mutated at the gatekeeper residue Ser 191, which is critical for 1NM-PP1 susceptibility. Host cell lysis of RH/ku80-/HA-TgMAPKL-1S191A was completely inhibited at 250 nM 1NM-PP1, whereas that of RH/ku80-/HA-TgMAPKL-1S191Y was not. By comparing 1NM-PP1-sensitive (RH/ku80-/HA-TgMAPKL-1S191A and -resistant (RH/ku80-/HA-TgMAPKL-1S191Y clones, we observed that inhibition of TgMAPKL-1 blocked cell cycle progression after DNA duplication. Morphological analysis revealed that TgMAPKL-1 inhibition caused enlarged parasite cells with many daughter cell scaffolds and imcomplete cytokinesis. We conclude that the mutation in TgMAPKL-1 restored the cell cycle-arresting effect of 1NM-PP1 on T. gondii endodyogeny. Given that endodyogeny is the primary mechanism of cell division for both the tachyzoite and bradyzoite stages of this parasite, TgMAPKL-1 may be a promising target for drug development. Exploration of the signals that regulate TgMAPKL-1 will provide further insights into the unique mode of T. gondii cell division.

  19. A single mutation in the gatekeeper residue in TgMAPKL-1 restores the inhibitory effect of a bumped kinase inhibitor on the cell cycle.

    Science.gov (United States)

    Sugi, Tatsuki; Kawazu, Shin-Ichiro; Horimoto, Taisuke; Kato, Kentaro

    2015-04-01

    Toxoplasma gondii is the causative pathogen for Toxoplasmosis. Bumped kinase inhibitor 1NM-PP1 inhibits the growth of T. gondii by targeting TgCDPK1. However, we recently reported that resistance to 1NM-PP1 can be acquired via a mutation in T. gondii mitogen-activated protein kinase like 1 (TgMAPKL-1). Further characterization of how this TgMAPKL-1 mutation restores the inhibitory effect of 1NM-PP1 would shed further light on the function of TgMAPKL-1 in the parasite life cycle. Therefore, we made parasite clones with TgMAPKL-1 mutated at the gatekeeper residue Ser 191, which is critical for 1NM-PP1 susceptibility. Host cell lysis of RH/ku80(-)/HA-TgMAPKL-1(S191A) was completely inhibited at 250 nM 1NM-PP1, whereas that of RH/ku80(-)/HA-TgMAPKL-1(S191Y) was not. By comparing 1NM-PP1-sensitive (RH/ku80(-)/HA-TgMAPKL-1(S191A)) and -resistant (RH/ku80(-)/HA-TgMAPKL-1(S191Y)) clones, we observed that inhibition of TgMAPKL-1 blocked cell cycle progression after DNA duplication. Morphological analysis revealed that TgMAPKL-1 inhibition caused enlarged parasite cells with many daughter cell scaffolds and imcomplete cytokinesis. We conclude that the mutation in TgMAPKL-1 restored the cell cycle-arresting effect of 1NM-PP1 on T. gondii endodyogeny. Given that endodyogeny is the primary mechanism of cell division for both the tachyzoite and bradyzoite stages of this parasite, TgMAPKL-1 may be a promising target for drug development. Exploration of the signals that regulate TgMAPKL-1 will provide further insights into the unique mode of T. gondii cell division.

  20. Shuttle orbit IMU alignment. Single-precision computation error

    Science.gov (United States)

    Mcclain, C. R.

    1980-01-01

    The source of computational error in the inertial measurement unit (IMU) onorbit alignment software was investigated. Simulation runs were made on the IBM 360/70 computer with the IMU orbit alignment software coded in hal/s. The results indicate that for small IMU misalignment angles (less than 600 arc seconds), single precision computations in combination with the arc cosine method of eigen rotation angle extraction introduces an additional misalignment error of up to 230 arc seconds per axis. Use of the arc sine method, however, produced negligible misalignment error. As a result of this study, the arc sine method was recommended for use in the IMU onorbit alignment software.

  1. Precision of single-engage micro Hall effect measurements

    DEFF Research Database (Denmark)

    Henrichsen, Henrik Hartmann; Hansen, Ole; Kjær, Daniel

    2014-01-01

    Recently a novel microscale Hall effect measurement technique has been developed to extract sheet resistance (RS), Hall sheet carrier density (NHS) and Hall mobility (μH) from collinear micro 4-point probe measurements in the vicinity of an insulating boundary [1]. The technique measures in less......]. In this study we calculate the measurement error on RS, NHS and μH resulting from electrode position errors, probe placement, sample size and Hall signal magnitude. We show the relationship between measurement precision and electrode pitch, which is important when down-scaling the micro 4-point probe to fit...

  2. Electromembrane extraction

    DEFF Research Database (Denmark)

    Huang, Chuixiu; Chen, Zhiliang; Gjelstad, Astrid

    2017-01-01

    Electromembrane extraction (EME) was inspired by solid-phase microextraction and developed from hollow fiber liquid-phase microextraction in 2006 by applying an electric field over the supported liquid membrane (SLM). EME provides rapid extraction, efficient sample clean-up and selectivity based...

  3. Vacuum extraction

    DEFF Research Database (Denmark)

    Maagaard, Mathilde; Oestergaard, Jeanett; Johansen, Marianne

    2012-01-01

    Objectives. To develop and validate an Objective Structured Assessment of Technical Skills (OSATS) scale for vacuum extraction. Design. Two part study design: Primarily, development of a procedure-specific checklist for vacuum extraction. Hereafter, validationof the developed OSATS scale for vacuum...

  4. 40 CFR 75.41 - Precision criteria.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Precision criteria. 75.41 Section 75.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTINUOUS EMISSION MONITORING Alternative Monitoring Systems § 75.41 Precision criteria. (a) Data collection...

  5. Precision Education Initiative: Moving toward Personalized Education

    Science.gov (United States)

    Hart, Sara A.

    2016-01-01

    This article proposes the Precision Education Initiative, which is the tailoring of education to the specific characteristics of the individual student. Mirroring precision medicine, the author lays out both near-term and longer term goals that educational research, and importantly educational practice, should follow.

  6. High precision laser forming for micro actuation

    NARCIS (Netherlands)

    Folkersma, Ger; Römer, Gerardus Richardus, Bernardus, Engelina; Brouwer, Dannis Michel; Huis in 't Veld, Bert; Nakata, Yoshiki; Xu, Xianfan; Roth, Stephan; Neuenschwander, Beat

    2014-01-01

    For assembly of micro-devices, such as photonic devices, the precision alignment of components is often critical for their performance. Laser forming, also known as laser-adjusting, can be used to create an integrated microactuator to align the components with sub-micron precision after bonding. In

  7. Ultra-precision processes for optics manufacturing

    Science.gov (United States)

    Martin, William R.

    1991-12-01

    The Optics MODIL (Manufacturing Operations Development and Integration Laboratory) is developing advanced manufacturing technologies for fabrication of ultra precision optical components, aiming for a ten-fold improvement in precision and a shortening of the scheduled lead time. Current work focuses on diamond single point turning, ductile grinding, ion milling, and in/on process metrology.

  8. The new field of 'precision psychiatry'.

    Science.gov (United States)

    Fernandes, Brisa S; Williams, Leanne M; Steiner, Johann; Leboyer, Marion; Carvalho, André F; Berk, Michael

    2017-04-13

    Precision medicine is a new and important topic in psychiatry. Psychiatry has not yet benefited from the advanced diagnostic and therapeutic technologies that form an integral part of other clinical specialties. Thus, the vision of precision medicine as applied to psychiatry - 'precision psychiatry' - promises to be even more transformative than in other fields of medicine, which have already lessened the translational gap. Herein, we describe 'precision psychiatry' and how its several implications promise to transform the psychiatric landscape. We pay particular attention to biomarkers and to how the development of new technologies now makes their discovery possible and timely. The adoption of the term 'precision psychiatry' will help propel the field, since the current term 'precision medicine', as applied to psychiatry, is impractical and does not appropriately distinguish the field. Naming the field 'precision psychiatry' will help establish a stronger, unique identity to what promises to be the most important area in psychiatry in years to come. In summary, we provide a wide-angle lens overview of what this new field is, suggest how to propel the field forward, and provide a vision of the near future, with 'precision psychiatry' representing a paradigm shift that promises to change the landscape of how psychiatry is currently conceived.

  9. Electroweak precision data and gravitino dark matter

    Indian Academy of Sciences (India)

    Electroweak precision measurements can provide indirect information about the possible scale of supersymmetry already at the present level of accuracy. We review present day sensitivities of precision data in mSUGRA-type models with the gravitino as the lightest supersymmetric particle (LSP). The 2 fit is based on , ...

  10. Analysis of Precision of Activation Analysis Method

    DEFF Research Database (Denmark)

    Heydorn, Kaj; Nørgaard, K.

    1973-01-01

    The precision of an activation-analysis method prescribes the estimation of the precision of a single analytical result. The adequacy of these estimates to account for the observed variation between duplicate results from the analysis of different samples and materials, is tested by the statistic T...

  11. Precision medicine for psychopharmacology: a general introduction.

    Science.gov (United States)

    Shin, Cheolmin; Han, Changsu; Pae, Chi-Un; Patkar, Ashwin A

    2016-07-01

    Precision medicine is an emerging medical model that can provide accurate diagnoses and tailored therapeutic strategies for patients based on data pertaining to genes, microbiomes, environment, family history and lifestyle. Here, we provide basic information about precision medicine and newly introduced concepts, such as the precision medicine ecosystem and big data processing, and omics technologies including pharmacogenomics, pharamacometabolomics, pharmacoproteomics, pharmacoepigenomics, connectomics and exposomics. The authors review the current state of omics in psychiatry and the future direction of psychopharmacology as it moves towards precision medicine. Expert commentary: Advances in precision medicine have been facilitated by achievements in multiple fields, including large-scale biological databases, powerful methods for characterizing patients (such as genomics, proteomics, metabolomics, diverse cellular assays, and even social networks and mobile health technologies), and computer-based tools for analyzing large amounts of data.

  12. Precision surveying the principles and geomatics practice

    CERN Document Server

    Ogundare, John Olusegun

    2016-01-01

    A comprehensive overview of high precision surveying, including recent developments in geomatics and their applications This book covers advanced precision surveying techniques, their proper use in engineering and geoscience projects, and their importance in the detailed analysis and evaluation of surveying projects. The early chapters review the fundamentals of precision surveying: the types of surveys; survey observations; standards and specifications; and accuracy assessments for angle, distance and position difference measurement systems. The book also covers network design and 3-D coordinating systems before discussing specialized topics such as structural and ground deformation monitoring techniques and analysis, mining surveys, tunneling surveys, and alignment surveys. Precision Surveying: The Principles and Geomatics Practice: * Covers structural and ground deformation monitoring analysis, advanced techniques in mining and tunneling surveys, and high precision alignment of engineering structures *...

  13. An aberrant precision account of autism.

    Directory of Open Access Journals (Sweden)

    Rebecca P Lawson

    2014-05-01

    Full Text Available Autism is a neurodevelopmental disorder characterised by problems with social-communication, restricted interests and repetitive behaviour. A recent and controversial article presented a compelling normative explanation for the perceptual symptoms of autism in terms of a failure of Bayesian inference (Pellicano and Burr, 2012. In response, we suggested that when Bayesian interference is grounded in its neural instantiation – namely, predictive coding – many features of autistic perception can be attributed to aberrant precision (or beliefs about precision within the context of hierarchical message passing in the brain (Friston et al., 2013. Here, we unpack the aberrant precision account of autism. Specifically, we consider how empirical findings – that speak directly or indirectly to neurobiological mechanisms – are consistent with the aberrant encoding of precision in autism; in particular, an imbalance of the precision ascribed to sensory evidence relative to prior beliefs.

  14. Precise measurement of volume of eccrine sweat gland in mental sweating by optical coherence tomography

    Science.gov (United States)

    Sugawa, Yoshihiko; Fukuda, Akihiro; Ohmi, Masato

    2015-04-01

    We have demonstrated dynamic analysis of the physiological function of eccrine sweat glands underneath skin surface by optical coherence tomography (OCT). In this paper, we propose a method for extraction of the specific eccrine sweat gland by means of the connected component extraction process and the adaptive threshold method, where the en face OCT images are constructed by the swept-source OCT. In the experiment, we demonstrate precise measurement of the volume of the sweat gland in response to the external stimulus.

  15. [Precision Nursing: Individual-Based Knowledge Translation].

    Science.gov (United States)

    Chiang, Li-Chi; Yeh, Mei-Ling; Su, Sui-Lung

    2016-12-01

    U.S. President Obama announced a new era of precision medicine in the Precision Medicine Initiative (PMI). This initiative aims to accelerate the progress of personalized medicine in light of individual requirements for prevention and treatment in order to improve the state of individual and public health. The recent and dramatic development of large-scale biologic databases (such as the human genome sequence), powerful methods for characterizing patients (such as genomics, microbiome, diverse biomarkers, and even pharmacogenomics), and computational tools for analyzing big data are maximizing the potential benefits of precision medicine. Nursing science should follow and keep pace with this trend in order to develop empirical knowledge and expertise in the area of personalized nursing care. Nursing scientists must encourage, examine, and put into practice innovative research on precision nursing in order to provide evidence-based guidance to clinical practice. The applications in personalized precision nursing care include: explanations of personalized information such as the results of genetic testing; patient advocacy and support; anticipation of results and treatment; ongoing chronic monitoring; and support for shared decision-making throughout the disease trajectory. Further, attention must focus on the family and the ethical implications of taking a personalized approach to care. Nurses will need to embrace the paradigm shift to precision nursing and work collaboratively across disciplines to provide the optimal personalized care to patients. If realized, the full potential of precision nursing will provide the best chance for good health for all.

  16. Mixed-Precision Spectral Deferred Correction: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Grout, Ray W. S.

    2015-09-02

    Convergence of spectral deferred correction (SDC), where low-order time integration methods are used to construct higher-order methods through iterative refinement, can be accelerated in terms of computational effort by using mixed-precision methods. Using ideas from multi-level SDC (in turn based on FAS multigrid ideas), some of the SDC correction sweeps can use function values computed in reduced precision without adversely impacting the accuracy of the final solution. This is particularly beneficial for the performance of combustion solvers such as S3D [6] which require double precision accuracy but are performance limited by the cost of data motion.

  17. Increased localization precision by interference fringe analysis

    Science.gov (United States)

    Ebeling, Carl G.; Meiri, Amihai; Martineau, Jason; Zalevsky, Zeev; Gerton, Jordan M.; Menon, Rajesh

    2015-06-01

    We report a novel optical single-emitter-localization methodology that uses the phase induced by path length differences in a Mach-Zehnder interferometer to improve localization precision. Using information theory, we demonstrate that the localization capability of a modified Fourier domain signal generated by photon interference enables a more precise localization compared to a standard Gaussian intensity distribution of the corresponding point-spread function. The calculations were verified by numerical simulations and an exemplary experiment, where the centers of metal nanoparticles were localized to a precision of 3 nm.

  18. Advances in Precision Medicine: Tailoring Individualized Therapies.

    Science.gov (United States)

    Matchett, Kyle B; Lynam-Lennon, Niamh; Watson, R William; Brown, James A L

    2017-10-25

    The traditional bench-to-bedside pipeline involves using model systems and patient samples to provide insights into pathways deregulated in cancer. This discovery reveals new biomarkers and therapeutic targets, ultimately stratifying patients and informing cohort-based treatment options. Precision medicine (molecular profiling of individual tumors combined with established clinical-pathological parameters) reveals, in real-time, individual patient's diagnostic and prognostic risk profile, informing tailored and tumor-specific treatment plans. Here we discuss advances in precision medicine presented at the Irish Association for Cancer Research Annual Meeting, highlighting examples where personalized medicine approaches have led to precision discovery in individual tumors, informing customized treatment programs.

  19. A Bump on the Head

    Centers for Disease Control (CDC) Podcasts

    2011-02-15

    In this podcast for kids, the Kidtastics talk about concussions, including how serious they are, symptoms, what to do if you think you have one, and tips for preventing them.  Created: 2/15/2011 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 2/15/2011.

  20. Say No to Speed Bumps!

    Science.gov (United States)

    Brannon, Sian

    2010-01-01

    No matter how cutting edge (and nicely funded) one's library is, there is always something cooler and more efficient on the horizon. Granted, not all new technology may be necessary in the library. But chances are one is going to want to get something--RFID (radio frequency identification), text reference, downloadable content, gaming,…

  1. Precise subtyping for synchronous multiparty sessions

    Directory of Open Access Journals (Sweden)

    Mariangiola Dezani-Ciancaglini

    2016-02-01

    Full Text Available The notion of subtyping has gained an important role both in theoretical and applicative domains: in lambda and concurrent calculi as well as in programming languages. The soundness and the completeness, together referred to as the preciseness of subtyping, can be considered from two different points of view: operational and denotational. The former preciseness has been recently developed with respect to type safety, i.e. the safe replacement of a term of a smaller type when a term of a bigger type is expected. The latter preciseness is based on the denotation of a type which is a mathematical object that describes the meaning of the type in accordance with the denotations of other expressions from the language. The result of this paper is the operational and denotational preciseness of the subtyping for a synchronous multiparty session calculus. The novelty of this paper is the introduction of characteristic global types to prove the operational completeness.

  2. An aberrant precision account of autism

    National Research Council Canada - National Science Library

    Lawson, Rebecca P; Rees, Geraint; Friston, Karl J

    2014-01-01

    ... (Pellicano and Burr, 2012). In response, we suggested that when Bayesian inference is grounded in its neural instantiation-namely, predictive coding-many features of autistic perception can be attributed to aberrant precision...

  3. The forthcoming era of precision medicine

    Directory of Open Access Journals (Sweden)

    Stjepan Gamulin

    2016-11-01

    Full Text Available Abstract. The aim of this essay is to present the definition and principles of personalized or precision medicine, the perspective and barriers to its development and clinical application. The implementation of precision medicine in health care requires the coordinated efforts of all health care stakeholders (the biomedical community, government, regulatory bodies, patients’ groups. Particularly, translational research with the integration of genomic and comprehensive data from all levels of the organism (“big data”, development of bioinformatics platforms enabling network analysis of disease etiopathogenesis, development of a legislative framework for handling personal data, and new paradigms of medical education are necessary for successful application of the concept of precision medicine in health care. Conclusion. In the present and future era of precision medicine, the collaboration of all participants in health care is necessary for its realization, resulting in improvement of diagnosis, prevention and therapy, based on a holistic, individually tailored approach.

  4. Nucleon measurements at the precision frontier

    Energy Technology Data Exchange (ETDEWEB)

    Carlson, Carl E. [Physics Department, College of William and Mary, Williamsburg, VA 23187 (United States)

    2013-11-07

    We comment on nucleon measurements at the precision frontier. As examples of what can be learned, we concentrate on three topics, which are parity violating scattering experiments, the proton radius puzzle, and the symbiosis between nuclear and atomic physics.

  5. Mechanics and Physics of Precise Vacuum Mechanisms

    CERN Document Server

    Deulin, E. A; Panfilov, Yu V; Nevshupa, R. A

    2010-01-01

    In this book the Russian expertise in the field of the design of precise vacuum mechanics is summarized. A wide range of physical applications of mechanism design in electronic, optical-electronic, chemical, and aerospace industries is presented in a comprehensible way. Topics treated include the method of microparticles flow regulation and its determination in vacuum equipment and mechanisms of electronics; precise mechanisms of nanoscale precision based on magnetic and electric rheology; precise harmonic rotary and not-coaxial nut-screw linear motion vacuum feedthroughs with technical parameters considered the best in the world; elastically deformed vacuum motion feedthroughs without friction couples usage; the computer system of vacuum mechanisms failure predicting. This English edition incorporates a number of features which should improve its usefulness as a textbook without changing the basic organization or the general philosophy of presentation of the subject matter of the original Russian work. Exper...

  6. Prospects for Precision Neutrino Cross Section Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Harris, Deborah A. [Fermilab

    2016-01-28

    The need for precision cross section measurements is more urgent now than ever before, given the central role neutrino oscillation measurements play in the field of particle physics. The definition of precision is something worth considering, however. In order to build the best model for an oscillation experiment, cross section measurements should span a broad range of energies, neutrino interaction channels, and target nuclei. Precision might better be defined not in the final uncertainty associated with any one measurement but rather with the breadth of measurements that are available to constrain models. Current experience shows that models are better constrained by 10 measurements across different processes and energies with 10% uncertainties than by one measurement of one process on one nucleus with a 1% uncertainty. This article describes the current status of and future prospects for the field of precision cross section measurements considering the metric of how many processes, energies, and nuclei have been studied.

  7. Precision Munition Electro-Sciences Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This facility allows the characterization of the electro-magnetic environment produced by a precision weapon in free flight. It can measure the radiofrequency (RF)...

  8. Courseware Review: Vernier Software: Precision Timer II.

    Science.gov (United States)

    Park, John C.

    1988-01-01

    Reviews "Vernier Software: Precision Timer II" for high school through college mechanics. Introduces 14 different modes including pulse time, pendulum timer, bouncer timer, gate timer, collision timers, and stroke calibration. Provides two typical displays and ratings of the software. (YP)

  9. Methods for precise photoelectron counting with photomultipliers

    Energy Technology Data Exchange (ETDEWEB)

    Dossi, R.; Ianni, A.; Ranucci, G.; Smirnov, O.Ju. E-mail: smirnov@lngs.infn.itsmipol@cv.jinr.ru

    2000-09-11

    A series of measurements has been performed on a THORN EMI 9351 phototube in order to investigate its response to a low light intensity. Precise procedures to determine the intensity of the incident photon flux have been developed and compared. The data show that the various approaches give consistent and reliable results, thus allowing the precise calibration of the device for applications of photon counting.

  10. A path to precision in the ICU.

    Science.gov (United States)

    Maslove, David M; Lamontagne, Francois; Marshall, John C; Heyland, Daren K

    2017-04-03

    Precision medicine is increasingly touted as a groundbreaking new paradigm in biomedicine. In the ICU, the complexity and ambiguity of critical illness syndromes have been identified as fundamental justifications for the adoption of a precision approach to research and practice. Inherently protean diseases states such as sepsis and acute respiratory distress syndrome have manifestations that are physiologically and anatomically diffuse, and that fluctuate over short periods of time. This leads to considerable heterogeneity among patients, and conditions in which a "one size fits all" approach to therapy can lead to widely divergent results. Current ICU therapy can thus be seen as imprecise, with the potential to realize substantial gains from the adoption of precision medicine approaches. A number of challenges still face the development and adoption of precision critical care, a transition that may occur incrementally rather than wholesale. This article describes a few concrete approaches to addressing these challenges.First, novel clinical trial designs, including registry randomized controlled trials and platform trials, suggest ways in which conventional trials can be adapted to better accommodate the physiologic heterogeneity of critical illness. Second, beyond the "omics" technologies already synonymous with precision medicine, the data-rich environment of the ICU can generate complex physiologic signatures that could fuel precision-minded research and practice. Third, the role of computing infrastructure and modern informatics methods will be central to the pursuit of precision medicine in the ICU, necessitating close collaboration with data scientists. As work toward precision critical care continues, small proof-of-concept studies may prove useful in highlighting the potential of this approach.

  11. Towards precision medicine; a new biomedical cosmology.

    Science.gov (United States)

    Vegter, M W

    2018-02-10

    Precision Medicine has become a common label for data-intensive and patient-driven biomedical research. Its intended future is reflected in endeavours such as the Precision Medicine Initiative in the USA. This article addresses the question whether it is possible to discern a new 'medical cosmology' in Precision Medicine, a concept that was developed by Nicholas Jewson to describe comprehensive transformations involving various dimensions of biomedical knowledge and practice, such as vocabularies, the roles of patients and physicians and the conceptualisation of disease. Subsequently, I will elaborate my assessment of the features of Precision Medicine with the help of Michel Foucault, by exploring how precision medicine involves a transformation along three axes: the axis of biomedical knowledge, of biomedical power and of the patient as a self. Patients are encouraged to become the managers of their own health status, while the medical domain is reframed as a data-sharing community, characterised by changing power relationships between providers and patients, producers and consumers. While the emerging Precision Medicine cosmology may surpass existing knowledge frameworks; it obscures previous traditions and reduces research-subjects to mere data. This in turn, means that the individual is both subjected to the neoliberal demand to share personal information, and at the same time has acquired the positive 'right' to become a member of the data-sharing community. The subject has to constantly negotiate the meaning of his or her data, which can either enable self-expression, or function as a commanding Superego.

  12. Platform Precision Autopilot Overview and Mission Performance

    Science.gov (United States)

    Strovers, Brian K.; Lee, James A.

    2009-01-01

    The Platform Precision Autopilot is an instrument landing system-interfaced autopilot system, developed to enable an aircraft to repeatedly fly nearly the same trajectory hours, days, or weeks later. The Platform Precision Autopilot uses a novel design to interface with a NASA Gulfstream III jet by imitating the output of an instrument landing system approach. This technique minimizes, as much as possible, modifications to the baseline Gulfstream III jet and retains the safety features of the aircraft autopilot. The Platform Precision Autopilot requirement is to fly within a 5-m (16.4-ft) radius tube for distances to 200 km (108 nmi) in the presence of light turbulence for at least 90 percent of the time. This capability allows precise repeat-pass interferometry for the Unmanned Aerial Vehicle Synthetic Aperture Radar program, whose primary objective is to develop a miniaturized, polarimetric, L-band synthetic aperture radar. Precise navigation is achieved using an accurate differential global positioning system developed by the Jet Propulsion Laboratory. Flight-testing has demonstrated the ability of the Platform Precision Autopilot to control the aircraft within the specified tolerance greater than 90 percent of the time in the presence of aircraft system noise and nonlinearities, constant pilot throttle adjustments, and light turbulence.

  13. Precision validation of MIPAS-Envisat products

    Directory of Open Access Journals (Sweden)

    C. Piccolo

    2007-01-01

    Full Text Available This paper discusses the variation and validation of the precision, or estimated random error, associated with the ESA Level 2 products from the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS. This quantity represents the propagation of the radiometric noise from the spectra through the retrieval process into the Level 2 profile values. The noise itself varies with time, steadily rising between ice decontamination events, but the Level 2 precision has a greater variation due to the atmospheric temperature which controls the total radiance received. Hence, for all species, the precision varies latitudinally/seasonally with temperature, with a small superimposed temporal structure determined by the degree of ice contamination on the detectors. The precision validation involves comparing two MIPAS retrievals at the intersections of ascending/descending orbits. For 5 days per month of full resolution MIPAS operation, the standard deviation of the matching profile pairs is computed and compared with the precision given in the MIPAS Level 2 data, except for NO2 since it has a large diurnal variation between ascending/descending intersections. Even taking into account the propagation of the pressure-temperature retrieval errors into the VMR retrieval, the standard deviation of the matching pairs is usually a factor 1–2 larger than the precision. This is thought to be due to effects such as horizontal inhomogeneity of the atmosphere and instability of the retrieval.

  14. Precision medicine needs pioneering clinical bioinformaticians.

    Science.gov (United States)

    Gómez-López, Gonzalo; Dopazo, Joaquín; Cigudosa, Juan C; Valencia, Alfonso; Al-Shahrour, Fátima

    2017-10-25

    Success in precision medicine depends on accessing high-quality genetic and molecular data from large, well-annotated patient cohorts that couple biological samples to comprehensive clinical data, which in conjunction can lead to effective therapies. From such a scenario emerges the need for a new professional profile, an expert bioinformatician with training in clinical areas who can make sense of multi-omics data to improve therapeutic interventions in patients, and the design of optimized basket trials. In this review, we first describe the main policies and international initiatives that focus on precision medicine. Secondly, we review the currently ongoing clinical trials in precision medicine, introducing the concept of 'precision bioinformatics', and we describe current pioneering bioinformatics efforts aimed at implementing tools and computational infrastructures for precision medicine in health institutions around the world. Thirdly, we discuss the challenges related to the clinical training of bioinformaticians, and the urgent need for computational specialists capable of assimilating medical terminologies and protocols to address real clinical questions. We also propose some skills required to carry out common tasks in clinical bioinformatics and some tips for emergent groups. Finally, we explore the future perspectives and the challenges faced by precision medicine bioinformatics. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  15. Principles of precision medicine in stroke.

    Science.gov (United States)

    Hinman, Jason D; Rost, Natalia S; Leung, Thomas W; Montaner, Joan; Muir, Keith W; Brown, Scott; Arenillas, Juan F; Feldmann, Edward; Liebeskind, David S

    2017-01-01

    The era of precision medicine has arrived and conveys tremendous potential, particularly for stroke neurology. The diagnosis of stroke, its underlying aetiology, theranostic strategies, recurrence risk and path to recovery are populated by a series of highly individualised questions. Moreover, the phenotypic complexity of a clinical diagnosis of stroke makes a simple genetic risk assessment only partially informative on an individual basis. The guiding principles of precision medicine in stroke underscore the need to identify, value, organise and analyse the multitude of variables obtained from each individual to generate a precise approach to optimise cerebrovascular health. Existing data may be leveraged with novel technologies, informatics and practical clinical paradigms to apply these principles in stroke and realise the promise of precision medicine. Importantly, precision medicine in stroke will only be realised once efforts to collect, value and synthesise the wealth of data collected in clinical trials and routine care starts. Stroke theranostics, the ultimate vision of synchronising tailored therapeutic strategies based on specific diagnostic data, demand cerebrovascular expertise on big data approaches to clinically relevant paradigms. This review considers such challenges and delineates the principles on a roadmap for rational application of precision medicine to stroke and cerebrovascular health. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  16. Development of INCONEL 600 precision tube (1)

    Energy Technology Data Exchange (ETDEWEB)

    Joo, Yeong Han; Jo, Bong Hyeon; Lee, Dong Hee; Kim, Wan Kyo; Jeong, Pyeong Keun; Yoon, Hwang Lo; Chio, Seok Sik [Sammi Steel Co. Ltd., Changwon (Korea, Republic of)

    1994-07-01

    Steam generator, being connected with nuclear fuel reactor is one of the most important part of nuclear power plant and consists of a large number of INCONEL 600 tubes. Approximately 160 tons of tubes are needed for a single nuclear power plant. All of INCONEL 600 steam generator tubes for domestic nuclear power plants have been imported. The aim of this research is to develop INCONEL 600 precision tubes for steam generator of nuclear power plant. If this research is conducted successfully, we can produce nuclear fuel tubes, Ni-alloy precision tubes and stainless steel precision tubes for many purposes and technology of INCONEL 600 steam generator tubes are similar to those of other tubes above mentioned. In the current study, development of preliminary manufacturing process of INCONEL 600 precision tubes for steam generator and investigation of material`s metallurgical characteristics were conducted. The main scope of this research is as follows. First, the preliminary manufacturing process design was conducted after investigations of foreign manufacturing processes and technical reports. Second, the results of investigations of material`s metallurgical characteristics through the manufacturing process were applied to the production technology of tentative INCONEL 600 precision tubes for sample. Third, preliminary process routes were established and samples of INCONEL 600 precision tube were produced by this process. As the results of this research, 14 pieces of INCONEL 600 precision tubes were produced by preliminary manufacturing process and the material`s metallurgical characteristics were investigated through the processes. But the SCC test could not be conducted due to the absence of equipment. In order to apply the results of SCC test to the manufacturing process, we need a SCC tester which can simulate SCC characteristics under high temperature and high pressurized circulating water. 95 refs., 55 figs., 20 tabs.

  17. Precision forging technology for aluminum alloy

    Science.gov (United States)

    Deng, Lei; Wang, Xinyun; Jin, Junsong; Xia, Juchen

    2017-11-01

    Aluminum alloy is a preferred metal material for lightweight part manufacturing in aerospace, automobile, and weapon industries due to its good physical properties, such as low density, high specific strength, and good corrosion resistance. However, during forging processes, underfilling, folding, broken streamline, crack, coarse grain, and other macro- or microdefects are easily generated because of the deformation characteristics of aluminum alloys, including narrow forgeable temperature region, fast heat dissipation to dies, strong adhesion, high strain rate sensitivity, and large flow resistance. Thus, it is seriously restricted for the forged part to obtain precision shape and enhanced property. In this paper, progresses in precision forging technologies of aluminum alloy parts were reviewed. Several advanced precision forging technologies have been developed, including closed die forging, isothermal die forging, local loading forging, metal flow forging with relief cavity, auxiliary force or vibration loading, casting-forging hybrid forming, and stamping-forging hybrid forming. High-precision aluminum alloy parts can be realized by controlling the forging processes and parameters or combining precision forging technologies with other forming technologies. The development of these technologies is beneficial to promote the application of aluminum alloys in manufacturing of lightweight parts.

  18. Aging affects neural precision of speech encoding.

    Science.gov (United States)

    Anderson, Samira; Parbery-Clark, Alexandra; White-Schwoch, Travis; Kraus, Nina

    2012-10-10

    Older adults frequently report they can hear what is said but cannot understand the meaning, especially in noise. This difficulty may arise from the inability to process rapidly changing elements of speech. Aging is accompanied by a general slowing of neural processing and decreased neural inhibition, both of which likely interfere with temporal processing in auditory and other sensory domains. Age-related reductions in inhibitory neurotransmitter levels and delayed neural recovery can contribute to decreases in the temporal precision of the auditory system. Decreased precision may lead to neural timing delays, reductions in neural response magnitude, and a disadvantage in processing the rapid acoustic changes in speech. The auditory brainstem response (ABR), a scalp-recorded electrical potential, is known for its ability to capture precise neural synchrony within subcortical auditory nuclei; therefore, we hypothesized that a loss of temporal precision results in subcortical timing delays and decreases in response consistency and magnitude. To assess this hypothesis, we recorded ABRs to the speech syllable /da/ in normal hearing younger (18-30 years old) and older (60-67 years old) adult humans. Older adults had delayed ABRs, especially in response to the rapidly changing formant transition, and greater response variability. We also found that older adults had decreased phase locking and smaller response magnitudes than younger adults. Together, our results support the theory that older adults have a loss of temporal precision in the subcortical encoding of sound, which may account, at least in part, for their difficulties with speech perception.

  19. EXPANDING EXTRACTIONS

    NARCIS (Netherlands)

    Dietzenbacher, Erik; Lahr, Michael L.

    2013-01-01

    In this paper, we generalize hypothetical extraction techniques. We suggest that the effect of certain economic phenomena can be measured by removing them from an input-output (I-O) table and by rebalancing the set of I-O accounts. The difference between the two sets of accounts yields the

  20. Protein Extractability

    African Journals Online (AJOL)

    limited to high oleic acid oil and water purification property (Katayon et al., 2006; Foid et al., 2001 and. Folkard et al., 1993), whereas it contains up to. 332.5 g of crude protein per kg of sample (Jose et al., 1999). Studies to characterize the interaction effects of pH and salts on the extraction of. PROTEIN EXTRACTABILITY ...

  1. Nanotechnology: The new perspective in precision agriculture

    Directory of Open Access Journals (Sweden)

    Joginder Singh Duhan

    2017-09-01

    Full Text Available Nanotechnology is an interdisciplinary research field. In recent past efforts have been made to improve agricultural yield through exhaustive research in nanotechnology. The green revolution resulted in blind usage of pesticides and chemical fertilizers which caused loss of soil biodiversity and developed resistance against pathogens and pests as well. Nanoparticle-mediated material delivery to plants and advanced biosensors for precision farming are possible only by nanoparticles or nanochips. Nanoencapsulated conventional fertilizers, pesticides and herbicides helps in slow and sustained release of nutrients and agrochemicals resulting in precise dosage to the plants. Nanotechnology based plant viral disease detection kits are also becoming popular and are useful in speedy and early detection of viral diseases. In this article, the potential uses and benefits of nanotechnology in precision agriculture are discussed. The modern nanotechnology based tools and techniques have the potential to address the various problems of conventional agriculture and can revolutionize this sector.

  2. Atomic Precision in Nano-Electronics

    Science.gov (United States)

    Strachan, Douglas; Johnston, Danvers; Guiton, Beth; Lu, Ye; Datta, Sujit; Davies, Peter; Bonnell, Dawn; Johnson, Charlie

    2008-03-01

    One of the greatest challenges in developing molecular-scale devices is to fabricate and monitor their formation with atomic precision. Recently, we have developed an electromigration technique that employs feedback for controllably electromigrating a nano-scale electrode with atomic precision at room temperature [1]. We will discuss our recent progress advancing this technique towards atomically precise nano-electronics. This will include in-situ transmission electron microscopy which shows evidence for highly crystalline electrode formation and the parallel fabrication of nanogaps for scaling-up to very large-scale integrated-circuits. Our results have implications on the development of a wide range of novel molecular-scale devices. Funding provided by: NSF-NSEC/NBIC DMR-0425780, NSF-NIRT Grant No. 0304531, and MRSEC award No. DMR05-20020. [1] D. R. Strachan, et al., Appl. Phys. Lett. 86, 043109 (2005).

  3. High precision x ray lithographic masks

    Science.gov (United States)

    Pease, R. F.; Browning, R.

    1992-09-01

    This contract period was first concerned with winding up the projects on the embedded X-ray Mask structure and on the 'quantum lithography' idea. As a result of developments elsewhere it became clear that among the most critical issues in achieving high precision X-ray masks were those associated with achieving high precision in both feature size and feature placement in electron beam lithography. Most of the effort in this reporting period was aimed at achieving precision in feature size; notably an attack on the problem of proximity effects. There were two approaches: (1) A short term approach aimed at correcting effects in existing electron beam pattern generators (notably the ETEC MEBES 3 and 4) for feature sizes down 500 nm; and (2) A long term approach aimed at avoiding proximity effects by employing low energy electron exposure for feature size below 500 nm.

  4. Nanotechnology: The new perspective in precision agriculture.

    Science.gov (United States)

    Duhan, Joginder Singh; Kumar, Ravinder; Kumar, Naresh; Kaur, Pawan; Nehra, Kiran; Duhan, Surekha

    2017-09-01

    Nanotechnology is an interdisciplinary research field. In recent past efforts have been made to improve agricultural yield through exhaustive research in nanotechnology. The green revolution resulted in blind usage of pesticides and chemical fertilizers which caused loss of soil biodiversity and developed resistance against pathogens and pests as well. Nanoparticle-mediated material delivery to plants and advanced biosensors for precision farming are possible only by nanoparticles or nanochips. Nanoencapsulated conventional fertilizers, pesticides and herbicides helps in slow and sustained release of nutrients and agrochemicals resulting in precise dosage to the plants. Nanotechnology based plant viral disease detection kits are also becoming popular and are useful in speedy and early detection of viral diseases. In this article, the potential uses and benefits of nanotechnology in precision agriculture are discussed. The modern nanotechnology based tools and techniques have the potential to address the various problems of conventional agriculture and can revolutionize this sector.

  5. High-Precision Computation and Mathematical Physics

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, David H.; Borwein, Jonathan M.

    2008-11-03

    At the present time, IEEE 64-bit floating-point arithmetic is sufficiently accurate for most scientific applications. However, for a rapidly growing body of important scientific computing applications, a higher level of numeric precision is required. Such calculations are facilitated by high-precision software packages that include high-level language translation modules to minimize the conversion effort. This paper presents a survey of recent applications of these techniques and provides some analysis of their numerical requirements. These applications include supernova simulations, climate modeling, planetary orbit calculations, Coulomb n-body atomic systems, scattering amplitudes of quarks, gluons and bosons, nonlinear oscillator theory, Ising theory, quantum field theory and experimental mathematics. We conclude that high-precision arithmetic facilities are now an indispensable component of a modern large-scale scientific computing environment.

  6. Cost and Precision of Brownian Clocks

    CERN Document Server

    Barato, Andre C

    2016-01-01

    Brownian clocks are biomolecular networks that can count time. A paradigmatic example are proteins that go through a cycle thus regulating some oscillatory behaviour in a living system. Typically, such a cycle requires free energy often provided by ATP hydrolysis. We investigate the relation between the precision of such a clock and its thermodynamic costs. For clocks driven by a constant thermodynamic force, a given precision requires a minimal cost that diverges as the uncertainty of the clock vanishes. In marked contrast, we show that a clock driven by a periodic variation of an external protocol can achieve arbitrary precision at arbitrarily low cost. This result constitutes a fundamental difference between processes driven by a fixed thermodynamic force and those driven periodically. As a main technical tool, we map a periodically driven system with a deterministic protocol to one subject to an external protocol that changes in stochastic time intervals, which simplifies calculations significantly. In th...

  7. Precision guided firearms: disruptive small arms technology

    Science.gov (United States)

    Boyd, Bret; Lupher, John

    2013-05-01

    Precision Guided Firearms (PGFs) employ target tracking, a Heads-Up Display, and advanced fire control technology to amplify shooting precision at long range by eliminating the most common sources of shooter error, including aim, trigger jerk, and shot setup miscalculation. Regardless of skill level or experience, PGFs significantly increase first shot success probability when compared to traditional technology, even at extreme ranges of 1,200 yards or more. More than just a scope, PGFs are fully integrated systems based on standard caliber bolt action or semi-automatic rifles with a Networked Tracking Scope, Guided Trigger and precision conventional ammunition. Onboard wireless technology allows PGFs to connect with local and wide area networks to deliver voice, video and data to mobile devices and various communication networks. These technologies allow shooters to be more accurate, engage multiple targets at unknown ranges quickly, track and engage moving targets, and communicate via command and control networks.

  8. High precision detector robot arm system

    Energy Technology Data Exchange (ETDEWEB)

    Shu, Deming; Chu, Yong

    2017-01-31

    A method and high precision robot arm system are provided, for example, for X-ray nanodiffraction with an X-ray nanoprobe. The robot arm system includes duo-vertical-stages and a kinematic linkage system. A two-dimensional (2D) vertical plane ultra-precision robot arm supporting an X-ray detector provides positioning and manipulating of the X-ray detector. A vertical support for the 2D vertical plane robot arm includes spaced apart rails respectively engaging a first bearing structure and a second bearing structure carried by the 2D vertical plane robot arm.

  9. Pushing the precision frontier in Collider Physics

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    The interplay between precise theory predictions and experimental measurements has written a success story in particle physics. After a brief journey into history we will review recent developments which have led  to "revolutions" with regard to precision calculations and to new insights into the structure of quantum field theory. The second part of the talk will focus on phenomenology, especially on Higgs boson pair production as a window to physics beyond the Standard Model, manifesting itself in a modification of those Higgs couplings which are still to a large extent unconstrained, in particular the Higgs boson self-coupling.

  10. Precision tests of the standard electroweak model

    CERN Document Server

    1995-01-01

    High precision measurements of weak neutral current and charged current processes and of the properties of the Z and W bosons have established the standard electroweak model as correct down to a distance scale of 10-16 cm, and are a sensitive probe of possible underlying physics. In this book, all aspects of the program are considered in detail, including the structure of the standard model, radiative corrections, high precision experiments, and their implications. The major classes of experiments are surveyed, covering the experiments themselves, the data analysis, results, and prospects. Thi

  11. Engineering precision biomaterials for personalized medicine.

    Science.gov (United States)

    Aguado, Brian A; Grim, Joseph C; Rosales, Adrianne M; Watson-Capps, Jana J; Anseth, Kristi S

    2018-01-17

    As the demand for precision medicine continues to rise, the "one-size-fits-all" approach to designing medical devices and therapies is becoming increasingly outdated. Biomaterials have considerable potential for transforming precision medicine, but individual patient complexity often necessitates integrating multiple functions into a single device to successfully tailor personalized therapies. Here, we introduce an engineering strategy based on unit operations to provide a unified vocabulary and contextual framework to aid the design of biomaterial-based devices and accelerate their translation. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

  12. Precision Analysis of LEO Satellite Orbit Prediction

    Directory of Open Access Journals (Sweden)

    WANG Yafei

    2016-09-01

    Full Text Available The accuracy of different fitting intervals on the predicted orbit of different arc lengths was analyzed by using the dynamic fitting method and taken HY-2A satellite as an example. According to two orbit products, one was the precise orbit obtained by CNES and the other was rapid orbit computed by adopting zero-different reduced dynamic method, obtaining the precise predicted orbit. By the results, we can get that the 3DRMS is near 6dm by using 12h or 24h fitting orbit to forecast 12h arc; the 3DRMS is near 1m when forecasting 24h arc.

  13. Precise surface gravities of δ Scuti stars from asteroseismology

    Science.gov (United States)

    García Hernández, A.; Suárez, J. C.; Moya, A.; Monteiro, M. J. P. F. G.; Guo, Z.; Reese, D. R.; Pascual-Granado, J.; Barceló Forteza, S.; Martín-Ruiz, S.; Garrido, R.; Nieto, J.

    2017-10-01

    The work reported here demonstrates that it is possible to accurately determine surface gravities of δ Scuti (δ Sct) stars using the frequency content from high-precision photometry and a measurement of the parallax. Using a sample of 10 eclipsing binary systems with a δ Sct component and the unique δ Sct star discovered with a transiting planet, WASP-33, we were able to refine the Δν-\\bar{ρ } relation. Using this relation and parallaxes, we obtained independent values for the masses and radii, allowing us to calculate the surface gravities without any constraints from spectroscopic or binary analysis. A remarkably good agreement was found between our results and those published, extracted from the analysis of the radial velocities and light curves of the systems. This reinforces the potential of Δν as a valuable observable for δ Sct stars and settles the degeneracy problem for the log g determination through spectroscopy.

  14. Superallowed nuclear beta decay: Precision measurements for basic physics

    Science.gov (United States)

    Hardy, J. C.

    2012-11-01

    For 60 years, superallowed 0+→0+ nuclear beta decay has been used to probe the weak interaction, currently verifying the conservation of the vector current (CVC) to high precision (±0.01%) and anchoring the most demanding available test of the unitarity of the Cabibbo-Kobayashi-Maskawa (CKM) matrix (±0.06%), a fundamental pillar of the electroweak standard model. Each superallowed transition is characterized by its ft-value, a result obtained from three measured quantities: the total decay energy of the transition, its branching ratio, and the half-life of the parent state. Today's data set is composed of some 150 independent measurements of 13 separate superallowed transitions covering a wide range of parent nuclei from 10C to 74Rb. Excellent consistency among the average results for all 13 transitions - a prediction of CVC - also confirms the validity of the small transition-dependent theoretical corrections that have been applied to account for isospin symmetry breaking. With CVC consistency established, the value of the vector coupling constant, GV, has been extracted from the data and used to determine the top left element of the CKM matrix, Vud. With this result the top-row unitarity test of the CKM matrix yields the value 0.99995(61), a result that sets a tight limit on possible new physics beyond the standard model. To have any impact on these fundamental weak-interaction tests, any measurement must be made with a precision of 0.1% or better - a substantial experimental challenge well beyond the requirements of most nuclear physics measurements. I overview the current state of the field and outline some of the requirements that need to be met by experimentalists if they aim to make measurements with this high level of precision.

  15. Precise segmentation of 3-D magnetic resonance angiography.

    Science.gov (United States)

    El-Baz, Ayman; Elnakib, Ahmed; Khalifa, Fahmi; El-Ghar, Mohamed Abou; McClure, Patrick; Soliman, Ahmed; Gimel'farb, Georgy

    2012-07-01

    Accurate automatic extraction of a 3-D cerebrovascular system from images obtained by time-of-flight (TOF) or phase contrast (PC) magnetic resonance angiography (MRA) is a challenging segmentation problem due to the small size objects of interest (blood vessels) in each 2-D MRA slice and complex surrounding anatomical structures (e.g., fat, bones, or gray and white brain matter). We show that due to the multimodal nature of MRA data, blood vessels can be accurately separated from the background in each slice using a voxel-wise classification based on precisely identified probability models of voxel intensities. To identify the models, an empirical marginal probability distribution of intensities is closely approximated with a linear combination of discrete Gaussians (LCDG) with alternate signs, using our previous EM-based techniques for precise linear combination of Gaussian-approximation adapted to deal with the LCDGs. The high accuracy of the proposed approach is experimentally validated on 85 real MRA datasets (50 TOF and 35 PC) as well as on synthetic MRA data for special 3-D geometrical phantoms of known shapes.

  16. Precision Top-Quark Mass Measurements at CDF

    Energy Technology Data Exchange (ETDEWEB)

    Aaltonen, T.; /Helsinki Inst. of Phys.; Alvarez Gonzalez, B.; /Oviedo U. /Cantabria Inst. of Phys.; Amerio, S.; /INFN, Padua; Amidei, D.; /Michigan U.; Anastassov, A.; /Northwestern U. /Fermilab; Annovi, A.; /Frascati; Antos, J.; /Comenius U.; Apollinari, G.; /Fermilab; Appel, J.A.; /Fermilab; Arisawa, T.; /Waseda U.; Artikov, A.; /Dubna, JINR /Texas A-M

    2012-07-01

    We present a precision measurement of the top-quark mass using the full sample of Tevatron {radical}s = 1.96 TeV proton-antiproton collisions collected by the CDF II detector, corresponding to an integrated luminosity of 8.7 fb{sup -1}. Using a sample of t{bar t} candidate events decaying into the lepton+jets channel, we obtain distributions of the top-quark masses and the invariant mass of two jets from the W boson decays from data. We then compare these distributions to templates derived from signal and background samples to extract the top-quark mass and the energy scale of the calorimeter jets with in situ calibration. The likelihood fit of the templates from signal and background events to the data yields the single most-precise measurement of the top-quark mass, mtop = 172.85 {+-} 0.71 (stat) {+-} 0.85 (syst) GeV/c{sup 2}.

  17. EVALUATION OF THE PRECISION OF CLINICAL DIAGNOSIS IN PULPOPATHIES

    Directory of Open Access Journals (Sweden)

    Raluca Mihaela Rosca

    2011-09-01

    Full Text Available Most clinicians universally acknowledge the difficulty of establishing a precise clinical diagnosis of the pathological status of the pulpal-dentinary organ, considering both the diversity of the etiological factors and especially the different histopatological forms that may characterize the same lesion. The aim of the present investigation is to identify and quantify the precision of the presumtive diagnosis established on the basis of clinical data and of paraclinical exams, comparatively with the results of the morphopathological work, which establishes the final diagnosis. There have been analyzed 45 teeth, 43 of which with various inflammatory pulpal problems, and 2 clinically-healthy teeth, extracted from orthodontic reasons. Taking advantage of the fact that, along with the development of the treatment, the dental pulp was also available, after its taking over, the surgical piece was prepared and microscopically examined, which permitted an undisputable morphopathological dignosis. To attain scientifically valid results, both the clinically and the morphopathologically obtained results were statistically interpreted by the non-parametric Wilcoxon test. If, from a clinical perspective, most of the cases were classified as mild hyperemia and partially serous acute pulpitis, the morphopathological examination viewed them as irreversible pulpitis, with major supurative and necrotic modifications. The actual diagnosis means cannot establish whether the pulpitis is a serous, a purulent or a combined manifestation in the various pulp sections.

  18. Precision Half-life Measurement of 25Al

    Science.gov (United States)

    Long, Jacob; Ahn, Tan; Allen, Jacob; Bardayan, Daniel; Becchetti, Fredrich; Blankstein, Drew; Brodeur, Maxime; Burdette, Daniel; Frentz, Bryce; Hall, Matthew; Kelly, James; Kolata, James; O'Malley, Patrick; Schultz, Bradley; Strauss, Sabrina; Valverde, Adrian; TwinSol Collaboration

    2017-09-01

    In recent years, precision measurements have led to considerable advances in several areas of physics, including fundamental symmetry. Precise determination of ft values for superallowed mixed transitions between mirror nuclides could provide an avenue to test the theoretical corrections used to extract the Vud matrix element from superallowed pure Fermi transitions. Calculation of the ft value requires the half-life, branching ratio, and Q value. 25Al decay is of particular interest as its half-life is derived from a series of conflicting measurements, and the largest uncertainty on the ft value stems from the half-life uncertainty. The life-time was determined by the β counting of implanted 25Al on a Ta foil that was removed from the beam for counting. The 25Al beam was produced by a transfer reaction and separated by the TwinSol facility of the Nuclear Science Laboratory of the University of Notre Dame. The 25Al results will be presented with preliminary results of more recent half-life measurements. The National Science Foundation.

  19. Precision top-quark mass measurement at CDF.

    Science.gov (United States)

    Aaltonen, T; Alvarez González, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Appel, J A; Arisawa, T; Artikov, A; Asaadi, J; Ashmanskas, W; Auerbach, B; Aurisano, A; Azfar, F; Badgett, W; Bae, T; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Barria, P; Bartos, P; Bauce, M; Bedeschi, F; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Bhatti, A; Bisello, D; Bizjak, I; Bland, K R; Blumenfeld, B; Bocci, A; Bodek, A; Bortoletto, D; Boudreau, J; Boveia, A; Brigliadori, L; Bromberg, C; Brucken, E; Budagov, J; Budd, H S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Calamba, A; Calancha, C; Camarda, S; Campanelli, M; Campbell, M; Canelli, F; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chung, W H; Chung, Y S; Ciocci, M A; Clark, A; Clarke, C; Compostella, G; Convery, M E; Conway, J; Corbo, M; Cordelli, M; Cox, C A; Cox, D J; Crescioli, F; Cuevas, J; Culbertson, R; Dagenhart, D; d'Ascenzo, N; Datta, M; de Barbaro, P; Dell'Orso, M; Demortier, L; Deninno, M; Devoto, F; d'Errico, M; Di Canto, A; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Dorigo, M; Dorigo, T; Ebina, K; Elagin, A; Eppig, A; Erbacher, R; Errede, S; Ershaidat, N; Eusebi, R; Farrington, S; Feindt, M; Fernandez, J P; Field, R; Flanagan, G; Forrest, R; Frank, M J; Franklin, M; Freeman, J C; Funakoshi, Y; Furic, I; Gallinaro, M; Garcia, J E; Garfinkel, A F; Garosi, P; Gerberich, H; Gerchtein, E; Giagu, S; Giakoumopoulou, V; Giannetti, P; Gibson, K; Ginsburg, C M; Giokaris, N; Giromini, P; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldin, D; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Grinstein, S; Grosso-Pilcher, C; Group, R C; Guimaraes da Costa, J; Hahn, S R; Halkiadakis, E; Hamaguchi, A; Han, J Y; Happacher, F; Hara, K; Hare, D; Hare, M; Harr, R F; Hatakeyama, K; Hays, C; Heck, M; Heinrich, J; Herndon, M; Hewamanage, S; Hocker, A; Hopkins, W; Horn, D; Hou, S; Hughes, R E; Hurwitz, M; Husemann, U; Hussain, N; Hussein, M; Huston, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jang, D; Jayatilaka, B; Jeon, E J; Jindariani, S; Jones, M; Joo, K K; Jun, S Y; Junk, T R; Kamon, T; Karchin, P E; Kasmi, A; Kato, Y; Ketchum, W; Keung, J; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kim, Y J; Kimura, N; Kirby, M; Klimenko, S; Knoepfel, K; Kondo, K; Kong, D J; Konigsberg, J; Kotwal, A V; Kreps, M; Kroll, J; Krop, D; Kruse, M; Krutelyov, V; Kuhr, T; Kurata, M; Kwang, S; Laasanen, A T; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; LeCompte, T; Lee, E; Lee, H S; Lee, J S; Lee, S W; Leo, S; Leone, S; Lewis, J D; Limosani, A; Lin, C-J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, C; Liu, H; Liu, Q; Liu, T; Lockwitz, S; Loginov, A; Lucchesi, D; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lys, J; Lysak, R; Madrak, R; Maeshima, K; Maestro, P; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, C; Martínez, M; Mastrandrea, P; Matera, K; Mattson, M E; Mazzacane, A; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Mesropian, C; Miao, T; Mietlicki, D; Mitra, A; Miyake, H; Moed, S; Moggi, N; Mondragon, M N; Moon, C S; Moore, R; Morello, M J; Morlock, J; Movilla Fernandez, P; Mukherjee, A; Muller, Th; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Naganoma, J; Nakano, I; Napier, A; Nett, J; Neu, C; Neubauer, M S; Nielsen, J; Nodulman, L; Noh, S Y; Norniella, O; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Ortolan, L; Pagan Griso, S; Pagliarone, C; Palencia, E; Papadimitriou, V; Paramonov, A A; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Pianori, E; Pilot, J; Pitts, K; Plager, C; Pondrom, L; Poprocki, S; Potamianos, K; Prokoshin, F; Pranko, A; Ptohos, F; Punzi, G; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Renton, P; Rescigno, M; Riddick, T; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rodriguez, T; Rogers, E; Rolli, S; Roser, R; Ruffini, F; Ruiz, A; Russ, J; Rusu, V; Safonov, A; Sakumoto, W K; Sakurai, Y; Santi, L; Sato, K; Saveliev, V; Savoy-Navarro, A; Schlabach, P; Schmidt, A; Schmidt, E E; Schwarz, T; Scodellaro, L; Scribano, A; Scuri, F; Seidel, S; Seiya, Y; Semenov, A; Sforza, F; Shalhout, S Z; Shears, T; Shepard, P F; Shimojima, M; Shochet, M; Shreyber-Tecker, I; Simonenko, A; Sinervo, P; Sliwa, K; Smith, J R; Snider, F D; Soha, A; Sorin, V; Song, H; Squillacioti, P; Stancari, M; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Strycker, G L; Sudo, Y; Sukhanov, A; Suslov, I; Takemasa, K; Takeuchi, Y; Tang, J; Tecchio, M; Teng, P K; Thom, J; Thome, J; Thompson, G A; Thomson, E; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Trovato, M; Ukegawa, F; Uozumi, S; Varganov, A; Vázquez, F; Velev, G; Vellidis, C; Vidal, M; Vila, I; Vilar, R; Vizán, J; Vogel, M; Volpi, G; Wagner, P; Wagner, R L; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Wester, W C; Whiteson, D; Wicklund, A B; Wicklund, E; Wilbur, S; Wick, F; Williams, H H; Wilson, J S; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, H; Wright, T; Wu, X; Wu, Z; Yamamoto, K; Yamato, D; Yang, T; Yang, U K; Yang, Y C; Yao, W-M; Yeh, G P; Yi, K; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanetti, A; Zeng, Y; Zhou, C; Zucchelli, S

    2012-10-12

    We present a precision measurement of the top-quark mass using the full sample of Tevatron √s = 1.96 TeV proton-antiproton collisions collected by the CDF II detector, corresponding to an integrated luminosity of 8.7 fb(-1). Using a sample of tt¯ candidate events decaying into the lepton+jets channel, we obtain distributions of the top-quark masses and the invariant mass of two jets from the W boson decays from data. We then compare these distributions to templates derived from signal and background samples to extract the top-quark mass and the energy scale of the calorimeter jets with in situ calibration. The likelihood fit of the templates from signal and background events to the data yields the single most-precise measurement of the top-quark mass, M(top)=172.85±0.71(stat)±0.85(syst) GeV/c(2).

  20. Precision Medicine In Action | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... page please turn JavaScript on. Feature: NIH Precision Medicine Initiative Precision Medicine In Action Past Issues / Fall 2015 Table of ... Dishman "I am totally motivated to support precision medicine because I am one of the early prototype ...

  1. Self-generation of machining precision and its realization in lapping of super precision solid balls

    Institute of Scientific and Technical Information of China (English)

    Bopeng ZHANG

    2008-01-01

    This paper presents the principle of self-genera-tion of machining precision by explaining its basic concept and five necessary conditions for forming a system with self-organization capability. A self-generation system is a kind of system with self-organization capability. The self-generation of machining precision for solid balls with super precision is emphatically explained. From the view-point of self-organization, there are three types of systems including system S1 with the self-regulation capability, S2 with the self-determination capability of goals, and S3 with the self-organization capability. Although they are all closed loop control systems, they have different con-structions and functions. Necessary conditions for achiev-ing self-generation of machining precision are given. Establishment of the system for machining solid balls with super precision is discussed. Self-generation of machining precision for solid balls with super precision on the basis of the capability of self-removal of errors is presented. Self-generation includes the ability of self-removal of errors for solid balls, convergence of self-removal of errors, self-generation of precision, and self-generating system for the given.

  2. Adoption of Precision farming in Denmark

    DEFF Research Database (Denmark)

    Pedersen, Søren Marcus; Fountas, S.; Blackmore, S.

    2003-01-01

    The adoption of precision farming (PF)in Denmark has been studied through two mail surveys, personal interviews and focus groups with farmers and other stakeholders. Farmers are in general optimistic about PF but it is difficult to verify the economic and environmental gains. It has been difficult...

  3. Fundamental constants: The teamwork of precision

    Science.gov (United States)

    Myers, Edmund G.

    2014-02-01

    A new value for the atomic mass of the electron is a link in a chain of measurements that will enable a test of the standard model of particle physics with better than part-per-trillion precision. See Letter p.467

  4. 21 CFR 872.3165 - Precision attachment.

    Science.gov (United States)

    2010-04-01

    ... precision attachment or preformed bar is a device made of austenitic alloys or alloys containing 75 percent or greater gold and metals of the platinum group intended for use in prosthetic dentistry in... partial denture, to connect either an upper or lower partial denture to a tooth or a crown, or to connect...

  5. Precision Livestock Farming: het dier centraal

    NARCIS (Netherlands)

    Lokhorst, C.

    2010-01-01

    Dit essay gaat over het concept Precision Livestock Farming (PLF). Voor de melkveehouderij is dit beschreven in het Wageningen UR Livestock rapport 358 (Kees Lokhorst, Bert Ipema, Edwin Bleumer, 2010. Haalbaarheid precisielandbouw voor de Melkveehouderij, ISSN 1570 – 8616, 21pp). Het PLF-concept is

  6. Precision measurements of cosmic ray air showers

    NARCIS (Netherlands)

    Huege, T.; Bray, J. D.; Buitink, S.; Dallier, R.; Ekers, R. D.; Falcke, H.; James, C. W.; Martin, L.; Revenu, B.; Scholten, O.; Schröder, F. G.

    2014-01-01

    Supplemented with suitable buffering techniques, the low-frequency part of the SKA can be used as an ultra-precise detector for cosmic-ray air showers at very high energies. This would enable a wealth of scientific applications: the physics of the transition from Galactic to extragalactic cosmic

  7. Precision markedly attenuates repetitive lift capacity.

    Science.gov (United States)

    Collier, Brooke R; Holland, Laura; McGhee, Deirdre; Sampson, John A; Bell, Alison; Stapley, Paul J; Groeller, Herbert

    2014-01-01

    This study investigated the effect of precision on time to task failure in a repetitive whole-body manual handling task. Twelve participants were required to repetitively lift a box weighing 65% of their single repetition maximum to shoulder height using either precise or unconstrained box placement. Muscle activity, forces exerted at the ground, 2D body kinematics, box acceleration and psychophysical measures of performance were recorded until task failure was reached. With precision, time to task failure for repetitive lifting was reduced by 72%, whereas the duration taken to complete a single lift and anterior deltoid muscle activation increased by 39% and 25%, respectively. Yet, no significant difference was observed in ratings of perceived exertion or heart rate at task failure. In conclusion, our results suggest that when accuracy is a characteristic of a repetitive manual handling task, physical work capacity will decline markedly. The capacity to lift repetitively to shoulder height was reduced by 72% when increased accuracy was required to place a box upon a shelf. Lifting strategy and muscle activity were also modified, confirming practitioners should take into consideration movement precision when evaluating the demands of repetitive manual handling tasks.

  8. Precision irrigation for improving crop water management

    Science.gov (United States)

    Precision irrigation is gaining attention by the agricultural industry as a means to optimize water inputs, reduce environmental degradation from runoff or deep percolation and maintain crop yields. This presenation will discuss the mechanical and software framework of the irrigation scheduling sup...

  9. Ionospheric Modeling for Precise GNSS Applications

    NARCIS (Netherlands)

    Memarzadeh, Y.

    2009-01-01

    The main objective of this thesis is to develop a procedure for modeling and predicting ionospheric Total Electron Content (TEC) for high precision differential GNSS applications. As the ionosphere is a highly dynamic medium, we believe that to have a reliable procedure it is necessary to transfer

  10. High Precision Pressure Measurement with a Funnel

    Science.gov (United States)

    Lopez-Arias, T.; Gratton, L. M.; Oss, S.

    2008-01-01

    A simple experimental device for high precision differential pressure measurements is presented. Its working mechanism recalls that of a hydraulic press, where pressure is supplied by insufflating air under a funnel. As an application, we measure air pressure inside a soap bubble. The soap bubble is inflated and connected to a funnel which is…

  11. Lane Determination with GPS Precise Point Positioning

    NARCIS (Netherlands)

    Knoop, V.L.; de Bakker, P.F.; Tiberius, C.C.J.M.; van Arem, B.

    2017-01-01

    Modern intelligent transport solutions can achieve an improvement of traffic flow on motorways. With lane-specific measurements and lane-specific control, more measures are possible. Single frequency precise point positioning (PPP) is a newly developed and affordable technique to achieve an

  12. Bringing Precision Medicine to Community Oncologists.

    Science.gov (United States)

    2017-01-01

    Quest Diagnostics has teamed up with Memorial Sloan Kettering Cancer Center and IBM Watson Health to offer IBM Watson Genomics to its network of community cancer centers and hospitals. This new service aims to advance precision medicine by combining genomic tumor sequencing with the power of cognitive computing. ©2017 American Association for Cancer Research.

  13. High-precision positioning of radar scatterers

    NARCIS (Netherlands)

    Dheenathayalan, P.; Small, D.; Schubert, A.; Hanssen, R.F.

    2016-01-01

    Remote sensing radar satellites cover wide areas and provide spatially dense measurements, with millions of scatterers. Knowledge of the precise position of each radar scatterer is essential to identify the corresponding object and interpret the estimated deformation. The absolute position accuracy

  14. Precision Engineering within the National Ignition Campaign

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, J S; Carlisle, K; Klingmann, J L; Geraghty, P; Saito, T T; Montesanti, R C

    2010-02-17

    In this very brief talk, we'll discuss how precision engineering impacts 4 key areas of NIF: (1) Diamond turning of KDP crystals; (2) Mitigation of laser damage on optics; (3) Alignment of lasers, targets, diagnostics; (4) Target fabrication.

  15. Precise Interval Timer for Software Defined Radio

    Science.gov (United States)

    Pozhidaev, Aleksey (Inventor)

    2014-01-01

    A precise digital fractional interval timer for software defined radios which vary their waveform on a packet-by-packet basis. The timer allows for variable length in the preamble of the RF packet and allows to adjust boundaries of the TDMA (Time Division Multiple Access) Slots of the receiver of an SDR based on the reception of the RF packet of interest.

  16. Precision Machining Technology. Technical Committee Report.

    Science.gov (United States)

    Idaho State Dept. of Education, Boise. Div. of Vocational Education.

    This Technical Committee Report prepared by industry representatives in Idaho lists the skills currently necessary for an employee in that state to obtain a job in precision machining technology, retain a job once hired, and advance in that occupational field. (Task lists are grouped according to duty areas generally used in industry settings, and…

  17. Precision Machining Technologies. Occupational Competency Analysis Profile.

    Science.gov (United States)

    Ohio State Univ., Columbus. Vocational Instructional Materials Lab.

    This Occupational Competency Analysis Profile (OCAP), which is one of a series of OCAPs developed to identify the skills that Ohio employers deem necessary to entering a given occupation/occupational area, lists the occupational, academic, and employability skills required of individuals entering the occupation of precision machinist. The…

  18. Surface texture metrology for high precision surfaces

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard; Gasparin, Stefania; Tosello, Guido

    2010-01-01

    This paper introduces some of the challenges related to surface texture measurement of high precision surfaces. The paper is presenting two case studies related to polished tool surfaces and micro part surfaces. In both cases measuring instrumentation, measurement procedure and the measurement re...

  19. Movements, timing and precision of drummers

    DEFF Research Database (Denmark)

    Dahl, Sofia

    2017-01-01

    Percussion instruments vary a great deal in material properties and characteristics of the interaction. Most drums, however, produce sounds with well defined onsets and contact time between player and instrument can be very brief. Players of percussion need to have precise control of timing and s...

  20. Surfaces in Precision Engineering, Microengineering and Nanotechnology

    DEFF Research Database (Denmark)

    De Chiffre, Leonardo; Kunzmann, H.; Peggs, G. N.

    2003-01-01

    with precision engineering, microengineering and nanotechnology are presented, encompassing surfaces in computers, MEMS, biomedical systems, light and X-ray optics, as well as in chemical systems. Surface properties at micro and nanoscale are considered, including geometry as well as physical and chemical...

  1. Artificial Intelligence, Physiological Genomics, and Precision Medicine.

    Science.gov (United States)

    Williams, Anna Marie; Liu, Yong; Regner, Kevin R; Jotterand, Fabrice; Liu, Pengyuan; Liang, Mingyu

    2018-01-26

    Big data is a major driver in the development of precision medicine. Efficient analysis methods are needed to transform big data into clinically-actionable knowledge. To accomplish this, many researchers are turning towards machine learning (ML), an approach of artificial intelligence (AI) that utilizes modern algorithms to give computers the ability to learn. Much of the effort to advance ML for precision medicine has been focused on the development and implementation of algorithms and the generation of ever larger quantities of genomic sequence data and electronic health records. However, relevance and accuracy of the data are as important as quantity of data in the advancement of ML for precision medicine. For common diseases, physiological genomic readouts in disease-applicable tissues may be an effective surrogate to measure the effect of genetic and environmental factors and their interactions that underlie disease development and progression. Disease-applicable tissue may be difficult to obtain, but there are important exceptions such as kidney needle biopsy specimens. As AI continues to advance, new analytical approaches, including those that go beyond data correlation, need to be developed and ethical issues of AI need to be addressed. Physiological genomic readouts in disease-relevant tissues, combined with advanced AI, can be a powerful approach for precision medicine for common diseases.

  2. Proliferation of Precision Strike: Issues for Congress

    Science.gov (United States)

    2012-05-14

    CONUS) and striking targets anywhere in the world. Precision Guided Munition (PGM)—A weapon that uses a seeker to detect electromagnetic energy...Central Asian Countries Georgia Azerbaijan Armenia Yemen Oman Algeria Morocco Sub-Saharan Africa Peru Columbia Venezuela Central America Ecuador

  3. Precision Metal Fabrication. Florida Vocational Program Guide.

    Science.gov (United States)

    University of South Florida, Tampa. Dept. of Adult and Vocational Education.

    This guide identifies considerations in the organization, operation, and evaluation of secondary and postsecondary vocational education programs. It contains both a vocational program guide and Career Merit Achievement Plan (Career MAP) for precision metal fabrication. The guide contains the following sections: occupational description; program…

  4. Combination procedure for the precise determination of Z boson parameters from results of the LEP experiments

    CERN Document Server

    CERN. Geneva

    2001-01-01

    The precise determination of the Z boson parameters from the measurements at the Z resonance by the four collaborations ALEPH, DELPHI, L3 and OPAL in e+e- collisions at the large electron positron collider LEP at CERN is a landmark for precision tests of the electroweak theory. The four experiments measured quantities which were used to extract the mass and width of the Z boson, the hadronic cross-section at the pole of the resonance, the ratio of hadronic and leptonic decay widths, and the leptonic forward-backward asymmetries at the pole. The combination procedure based on these parameters is presented in this paper.

  5. The value of precision for image-based decision support in weed management

    DEFF Research Database (Denmark)

    Franco de los Ríos, Camilo; Pedersen, Søren Marcus; Papaharalampos, Haris

    2017-01-01

    Decision support methodologies in precision agriculture should integrate the different dimensions composing the added complexity of operational decision problems. Special attention has to be given to the adequate knowledge extraction techniques for making sense of the collected data, processing...... for the implementation of automatic weed recognition procedures. The objective of this paper is to develop a decision support methodology for detecting the undesired weed from aerial images, building an image-based viewpoint consisting in relevant operational knowledge for applying precision spraying. In this way...

  6. Fiber Scrambling for High Precision Spectrographs

    Science.gov (United States)

    Kaplan, Zachary; Spronck, J. F. P.; Fischer, D.

    2011-05-01

    The detection of Earth-like exoplanets with the radial velocity method requires extreme Doppler precision and long-term stability in order to measure tiny reflex velocities in the host star. Recent planet searches have led to the detection of so called "super-Earths” (up to a few Earth masses) that induce radial velocity changes of about 1 m/s. However, the detection of true Earth analogs requires a precision of 10 cm/s. One of the largest factors limiting Doppler precision is variation in the Point Spread Function (PSF) from observation to observation due to changes in the illumination of the slit and spectrograph optics. Thus, this stability has become a focus of current instrumentation work. Fiber optics have been used since the 1980's to couple telescopes to high-precision spectrographs, initially for simpler mechanical design and control. However, fiber optics are also naturally efficient scramblers. Scrambling refers to a fiber's ability to produce an output beam independent of input. Our research is focused on characterizing the scrambling properties of several types of fibers, including circular, square and octagonal fibers. By measuring the intensity distribution after the fiber as a function of input beam position, we can simulate guiding errors that occur at an observatory. Through this, we can determine which fibers produce the most uniform outputs for the severest guiding errors, improving the PSF and allowing sub-m/s precision. However, extensive testing of fibers of supposedly identical core diameter, length and shape from the same manufacturer has revealed the "personality” of individual fibers. Personality describes differing intensity patterns for supposedly duplicate fibers illuminated identically. Here, we present our results on scrambling characterization as a function of fiber type, while studying individual fiber personality.

  7. A Precision Analysis of Camera Distortion Models.

    Science.gov (United States)

    Tang, Zhongwei; Grompone von Gioi, Rafael; Monasse, Pascal; Morel, Jean-Michel

    2017-06-01

    This paper addresses the question of identifying the right camera direct or inverse distortion model, permitting a high subpixel precision to fit to real camera distortion. Five classic camera distortion models are reviewed and their precision is compared for direct or inverse distortion. By definition, the three radially symmetric models can only model a distortion radially symmetric around some distortion center. They can be extended to deal with non-radially symmetric distortions by adding tangential distortion components, but still may be too simple for very accurate modeling of real cameras. The polynomial and the rational models instead miss a physical or optical interpretation, but can cope equally with radially and non-radially symmetric distortions. Indeed, they do not require the evaluation of a distortion center. When requiring high precisions, we found that the distortion modeling must also be evaluated primarily as a numerical problem. Indeed, all models except the polynomial involve a non-linear minimization, which increases the numerical risk. The estimation of a polynomial distortion model leads instead to a linear problem, which is secure and much faster. We concluded by extensive numerical experiments that, although high degree polynomials were required to reach a high precision of 1/100 pixels, such polynomials were easily estimated and produced a precise distortion modeling without overfitting. Our conclusion is validated by three independent experimental setups: the models were compared first on the lens distortion database of the Lensfun library by their distortion simulation and inversion power; second by fitting real camera distortions estimated by a non parametric algorithm; and finally by the absolute correction measurement provided by the photographs of tightly stretched strings, warranting a high straightness.

  8. Increasing estimation precision in localization microscopy

    Science.gov (United States)

    Ebeling, Carl G.

    This dissertation studies detection-based methods to increase the estimation precision of single point-source emitters in the field of localization microscopy. Localization microscopy is a novel method allowing for the localization of optical point-source emitters below the Abbe diffraction limit of optical microscopy. This is accomplished by optically controlling the active, or bright, state of individual molecules within a sample. The use of time-multiplexing of the active state allows for the temporal and spatial isolation of single point-source emitters. Isolating individual sources within a sample allows for statistical analysis on their emission point-spread function profile, and the spatial coordinates of the point-source may be discerned below the optical response of the microscope system. Localization microscopy enables the identification of individual point-source emitter locations approximately an order of magnitude below standard, diffraction-limited optical techniques. The precision of localization microscopy methods is limited by the statistical uncertainty in which the location of these sources may be estimated. By utilizing a detection-based interferometer, an interference pattern may be super-imposed over the emission signal. Theoretical analysis and Monte-Carlo simulations by means of Fisher information theory demonstrate that the incorporation of a modulation structure over the emission signal allow for a more precise estimation when compared to conventional localization methods for the same number of recorded photons. These theoretical calculation and simulations are demonstrated through the use of two proof-of-concept experiments utilizing a modified Mach-Zehnder interferometer. The first methodology improves the localization precision of a single nanoparticle over the theoretical limit for an Airy-disk point-spread function by using self-interference to spatially modulate the recorded point-spread function. Experimental analysis demonstrates

  9. Precision medicine and precision therapeutics: hedgehog signaling pathway, basal cell carcinoma and beyond.

    Science.gov (United States)

    Mohan, Shalini V; Chang, Anne Lynn S

    2014-06-01

    Precision medicine and precision therapeutics is currently in its infancy with tremendous potential to improve patient care by better identifying individuals at risk for skin cancer and predict tumor responses to treatment. This review focuses on the Hedgehog signaling pathway, its critical role in the pathogenesis of basal cell carcinoma, and the emergence of targeted treatments for advanced basal cell carcinoma. Opportunities to utilize precision medicine are outlined, such as molecular profiling to predict basal cell carcinoma response to targeted therapy and to inform therapeutic decisions.

  10. Precision measurements of the CKM angle gamma

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    The level of CP-violation permitted within the Standard Model cannot account for the matter dominated universe in which we live. Within the Standard Model the CKM matrix, which describes the quark couplings, is expected to be unitary. By making precise measurements of the CKM matrix parameters new physics models can be constrained, or with sufficient precision the effects of physics beyond the standard model might become apparent. The CKM angle gamma is the least well known angle of the unitarity triangle. It is the only angle easily accessible at tree-level, and furthermore has almost no theoretical uncertainties. Therefore it provides an invaluable Standard Model benchmark against which other new physics sensitive tests of the CP-violation can be made. I will discuss recent measurements of gamma using the the Run 1 LHCb dataset, which improve our knowledge of this key parameter.

  11. Precision QCD in DIS at HERA

    Directory of Open Access Journals (Sweden)

    Rizvi Eram

    2013-11-01

    Full Text Available The HERA ep collider experiments have measured the proton structure functions over a wide kinematic range. New data from the H1 experiment now extend the range to higher 4-momentum transfer (√Q2 over which a precision of ~ 2% is achieved in the neutral current channel. A factor of two reduction in the systematic uncertainties over previous measurement is attained. The charged current structure function measurements are also significantly improved in precision. These data, when used in QCD analyses of the parton density functions (PDFs reduce the PDF uncertainties particularly at high momentum fractions x which is relevant to predictions for the LHC experiments as well as low energy neutrino scattering cross sections.

  12. Improving the precision of noisy oscillators

    Science.gov (United States)

    Moehlis, Jeff

    2014-04-01

    We consider how the period of an oscillator is affected by white noise, with special attention given to the cases of additive noise and parameter fluctuations. Our treatment is based upon the concepts of isochrons, which extend the notion of the phase of a stable periodic orbit to the basin of attraction of the periodic orbit, and phase response curves, which can be used to understand the geometry of isochrons near the periodic orbit. This includes a derivation of the leading-order effect of noise on the statistics of an oscillator’s period. Several examples are considered in detail, which illustrate the use and validity of the theory, and demonstrate how to improve a noisy oscillator’s precision by appropriately tuning system parameters or operating away from a bifurcation point. It is also shown that appropriately timed impulsive kicks can give further improvements to oscillator precision.

  13. Full-wave current conveyor precision rectifier

    Directory of Open Access Journals (Sweden)

    Đukić Slobodan R.

    2008-01-01

    Full Text Available A circuit that provides precision rectification of small signal with low temperature sensitivity for frequencies up to 100 kHz without waveform distortion is presented. It utilizes an improved second type current conveyor based on current-steering output stage and biased silicon diodes. The use of a DC current source to bias the rectifying diodes provides higher temperature stability and lower DC offset level at the output. Proposed design of the precision rectifier ensures good current transfer linearity in the range that satisfy class A of the amplifier and good voltage transfer characteristic for low level signals. Distortion during the zero crossing of the input signal is practically eliminated. Design of the proposed rectifier is realized with standard components.

  14. Optimizing mouse models for precision cancer prevention.

    Science.gov (United States)

    Le Magnen, Clémentine; Dutta, Aditya; Abate-Shen, Cory

    2016-03-01

    As cancer has become increasingly prevalent, cancer prevention research has evolved towards placing a greater emphasis on reducing cancer deaths and minimizing the adverse consequences of having cancer. 'Precision cancer prevention' takes into account the collaboration of intrinsic and extrinsic factors in influencing cancer incidence and aggressiveness in the context of the individual, as well as recognizing that such knowledge can improve early detection and enable more accurate discrimination of cancerous lesions. However, mouse models, and particularly genetically engineered mouse (GEM) models, have yet to be fully integrated into prevention research. In this Opinion article, we discuss opportunities and challenges for precision mouse modelling, including the essential criteria of mouse models for prevention research, representative success stories and opportunities for more refined analyses in future studies.

  15. Precisely timing dissipative quantum information processing

    Energy Technology Data Exchange (ETDEWEB)

    Kastoryano, Michael; Eisert, Jens [FU Berlin (Germany); Wolf, Michael [TU Muenchen (Germany)

    2013-07-01

    Dissipative engineering constitutes a framework within which quantum information processing protocols are powered by system-environment interaction rather than by unitary dynamics alone. This framework embraces noise as a resource, and consequently, offers a number of advantages compared to one based on unitary dynamics alone, e.g., that the protocols are typically independent of the initial state of the system. However, the time independent nature of this scheme makes it difficult to imagine precisely timed sequential operations, conditional measurements or error correction. In this work, we provide a path around these challenges, by introducing basic dissipative gadgets which allow us to precisely initiate, trigger and time dissipative operations, while keeping the system Liouvillian time-independent. These gadgets open up novel perspectives for thinking of timed dissipative quantum information processing. As an example, we sketch how measurement based computation can be simulated in the dissipative setting.

  16. Precision bridge circuit using a temperature sensor

    Science.gov (United States)

    Mount, Bruce E. (Inventor)

    1992-01-01

    A precision bridge measurement circuit connected to a current source providing a linear output voltage versus resistance change of a variable resistance (resistance temperature transducer) including a voltage follower in one branch of the bridge so that the zero setting of the transducer resistance does not depend upon the current source or upon an excitation voltage. The zero setting depends only on the precision and stability of the three resistances. By connecting the output of an instrumentation amplifier to a feedback resistor and then to the output of the voltage follower, minor nonlinearities in the resistance-vs-temperature output of a resistance-temperature transducer, such as a platinum temperature sensor, may be corrected. Sensors which have nonlinearity opposite in polarity to platinum, such as nickel-iron sensors, may be linearized by inserting an inverting amplifier into the feedback loop.

  17. Mobile Robotic Teams Applied to Precision Agriculture

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Matthew Oley; Kinoshita, Robert Arthur; Mckay, Mark D; Willis, Walter David; Gunderson, R.W.; Flann, N.S.

    1999-04-01

    The Idaho National Engineering and Environmental Laboratory (INEEL) and Utah State University’s Center for Self-Organizing and Intelligent Systems (CSOIS) have developed a team of autonomous robotic vehicles applicable to precision agriculture. A unique technique has been developed to plan, coordinate, and optimize missions in large structured environments for these autonomous vehicles in realtime. Two generic tasks are supported: 1) Driving to a precise location, and 2) Sweeping an area while activating on-board equipment. Sensor data and task achievement data is shared among the vehicles enabling them to cooperatively adapt to changing environmental, vehicle, and task conditions. This paper discusses the development of the autonomous robotic team, details of the mission-planning algorithm, and successful field demonstrations at the INEEL.

  18. Mobile Robotic Teams Applied to Precision Agriculture

    Energy Technology Data Exchange (ETDEWEB)

    M.D. McKay; M.O. Anderson; N.S. Flann (Utah State University); R.A. Kinoshita; R.W. Gunderson; W.D. Willis (INEEL)

    1999-04-01

    The Idaho National Engineering and Environmental Laboratory (INEEL) and Utah State University�s Center for Self-Organizing and Intelligent Systems (CSOIS) have developed a team of autonomous robotic vehicles applicable to precision agriculture. A unique technique has been developed to plan, coordinate, and optimize missions in large structured environments for these autonomous vehicles in real-time. Two generic tasks are supported: 1) Driving to a precise location, and 2) Sweeping an area while activating on-board equipment. Sensor data and task achievement data is shared among the vehicles enabling them to cooperatively adapt to changing environmental, vehicle, and task conditions. This paper discusses the development of the autonomous robotic team, details of the mission-planning algorithm, and successful field demonstrations at the INEEL.

  19. Radiotherapy in the Era of Precision Medicine.

    Science.gov (United States)

    Yard, Brian; Chie, Eui Kyu; Adams, Drew J; Peacock, Craig; Abazeed, Mohamed E

    2015-10-01

    Current predictors of radiation response are largely limited to clinical and histopathologic parameters, and extensive systematic analyses of the correlation between radiation sensitivity and genomic parameters remain lacking. In the era of precision medicine, the lack of -omic determinants of radiation response has hindered the personalization of radiation delivery to the unique characteristics of each patient׳s cancer and impeded the discovery of new therapies that can be administered concurrently with radiation therapy. The cataloging of the -omic determinants of radiation sensitivity of cancer has great potential in enhancing efficacy and limiting toxicity in the context of a new approach to precision radiotherapy. Herein, we review concepts and data that contribute to the delineation of the radiogenomic landscape of cancer. Copyright © 2015 Elsevier Inc. All rights reserved.

  20. Precision genetic engineering in large mammals.

    Science.gov (United States)

    Garrels, Wiebke; Ivics, Zoltan; Kues, Wilfried A

    2012-07-01

    Precision genetic engineering based on stable chromosomal insertion of exogenous DNA in the genomes of large mammals is immensely important for the development of improved biomedical models, pharmaceutical research and an accelerated breeding progress. Precision genetic engineering requires (i) a known locus of genomic integration, (ii) a defined status of foreign DNA, (iii) that transgene expression is unaffected by neighbouring chromosomal sequences, (iv) endogenous genes are not mutated and (v) no unwanted DNA sequences are present. Recently, advanced molecular techniques exploiting exogenous enzymes have opened the possibilities for more sophisticated genetic engineering. Here, we critically review current developments of enzyme-catalysed approaches for targeted transgenesis in large mammals. Copyright © 2012 Elsevier Ltd. All rights reserved.

  1. Precision measurements with LPCTrap at GANIL

    Energy Technology Data Exchange (ETDEWEB)

    Liénard, E., E-mail: lienard@lpccaen.in2p3.fr; Ban, G. [LPC CAEN, ENSICAEN, Université de Caen, CNRS/IN2P3 (France); Couratin, C. [Instituut voor Kern- en Stralingsfysica, KU Leuven (Belgium); Delahaye, P. [GANIL, CEA/DSM-CNRS/IN2P3 (France); Durand, D.; Fabian, X. [LPC CAEN, ENSICAEN, Université de Caen, CNRS/IN2P3 (France); Fabre, B. [CELIA, Université Bordeaux, CNRS, CEA (France); Fléchard, X. [LPC CAEN, ENSICAEN, Université de Caen, CNRS/IN2P3 (France); Finlay, P. [Instituut voor Kern- en Stralingsfysica, KU Leuven (Belgium); Mauger, F. [LPC CAEN, ENSICAEN, Université de Caen, CNRS/IN2P3 (France); Méry, A. [CIMAP, CEA/CNRS/ENSICAEN, Université de Caen (France); Naviliat-Cuncic, O. [NSCL and Department of Physics and Astronomy, MSU (United States); Pons, B. [CELIA, Université Bordeaux, CNRS, CEA (France); Porobic, T. [Instituut voor Kern- en Stralingsfysica, KU Leuven (Belgium); Quéméner, G. [LPC CAEN, ENSICAEN, Université de Caen, CNRS/IN2P3 (France); Severijns, N. [Instituut voor Kern- en Stralingsfysica, KU Leuven (Belgium); Thomas, J. C. [GANIL, CEA/DSM-CNRS/IN2P3 (France); Velten, Ph. [Instituut voor Kern- en Stralingsfysica, KU Leuven (Belgium)

    2015-11-15

    The experimental achievements and the results obtained so far with the LPCTrap device installed at GANIL are presented. The apparatus is dedicated to the study of the weak interaction at low energy by means of precise measurements of the β − ν angular correlation parameter in nuclear β decays. So far, the data collected with three isotopes have enabled to determine, for the first time, the charge state distributions of the recoiling ions, induced by shakeoff process. The analysis is presently refined to deduce the correlation parameters, with the potential of improving both the constraint deduced at low energy on exotic tensor currents ({sup 6}He{sup 1+}) and the precision on the V{sub ud} element of the quark-mixing matrix ({sup 35}Ar{sup 1+} and {sup 19}Ne{sup 1+}) deduced from the mirror transitions dataset.

  2. Precise accelerator models using measurements with beam

    OpenAIRE

    Zimmermann, Frank

    2000-01-01

    Precision accelerator models are increasingly important for achieving the design performance of colliders and light sources. An overview is given of procedures and techniques for measuring various parameters of the accelerator model, including the beta function, betatron phase, mismatch, nonlinear detuning, resonance-driving terms, impedance, linear coupling, dispersion, linear and non-linear chromaticity, momentum compaction and rf voltage. The complementary model-independent analysis is als...

  3. Precise accelerator models using measurements with beam

    CERN Document Server

    Zimmermann, Frank

    2000-01-01

    Precision accelerator models are increasingly important for achieving the design performance of colliders and light sources. An overview is given of procedures and techniques for measuring various parameters of the accelerator model, including the beta function, betatron phase, mismatch, nonlinear detuning, resonance-driving terms, impedance, linear coupling, dispersion, linear and non-linear chromaticity, momentum compaction and rf voltage. The complementary model-independent analysis is also discussed. More details and further information may be found in ref [1].

  4. Static quarks with improved statistical precision

    CERN Document Server

    Della Morte, M; Heitger, J; Molke, H; Rolf, J; Shindler, A; Sommer, R

    2004-01-01

    We present a numerical study for different discretisations of the static action, concerning cut-off effects and the growth of statistical errors with Euclidean time. An error reduction by an order of magnitude can be obtained with respect to the Eichten-Hill action, for time separations beyond 1.3 fm, keeping discretization errors small. The best actions lead to a big improvement on the precision of the quark mass Mb and F_Bs in the static approximation.

  5. Nanotechnology: The new perspective in precision agriculture

    OpenAIRE

    Joginder Singh Duhan; Ravinder Kumar; Naresh Kumar; Pawan Kaur; Kiran Nehra; Surekha Duhan

    2017-01-01

    Nanotechnology is an interdisciplinary research field. In recent past efforts have been made to improve agricultural yield through exhaustive research in nanotechnology. The green revolution resulted in blind usage of pesticides and chemical fertilizers which caused loss of soil biodiversity and developed resistance against pathogens and pests as well. Nanoparticle-mediated material delivery to plants and advanced biosensors for precision farming are possible only by nanoparticles or nanochip...

  6. Ionospheric Modeling for Precise GNSS Applications

    OpenAIRE

    Memarzadeh, Y.

    2009-01-01

    The main objective of this thesis is to develop a procedure for modeling and predicting ionospheric Total Electron Content (TEC) for high precision differential GNSS applications. As the ionosphere is a highly dynamic medium, we believe that to have a reliable procedure it is necessary to transfer the high temporal resolution GNSS network data into the spatial domain. This objective led to the development of a recursive physics-based model for the regular TEC variations and an algorithm for r...

  7. Precision Calibration of Infrared Synchrotron Radiation Detectors

    CERN Document Server

    Maltsev, A A; Maslova, M V

    2003-01-01

    The technique of calibration of synchrotron radiation precision detectors on a tungsten source based on similarity (close similarity) of character of spectral distributions of synchrotron and thermal radiations is given. The characteristics of various commonly used lamps, used as "standard" ones, are given. The errors of measurements are analyzed. The detectors are intended for absolute measurements of the number of electrons in a ring-shaped bunch.

  8. High-precision positioning of radar scatterers

    Science.gov (United States)

    Dheenathayalan, Prabu; Small, David; Schubert, Adrian; Hanssen, Ramon F.

    2016-05-01

    Remote sensing radar satellites cover wide areas and provide spatially dense measurements, with millions of scatterers. Knowledge of the precise position of each radar scatterer is essential to identify the corresponding object and interpret the estimated deformation. The absolute position accuracy of synthetic aperture radar (SAR) scatterers in a 2D radar coordinate system, after compensating for atmosphere and tidal effects, is in the order of centimeters for TerraSAR-X (TSX) spotlight images. However, the absolute positioning in 3D and its quality description are not well known. Here, we exploit time-series interferometric SAR to enhance the positioning capability in three dimensions. The 3D positioning precision is parameterized by a variance-covariance matrix and visualized as an error ellipsoid centered at the estimated position. The intersection of the error ellipsoid with objects in the field is exploited to link radar scatterers to real-world objects. We demonstrate the estimation of scatterer position and its quality using 20 months of TSX stripmap acquisitions over Delft, the Netherlands. Using trihedral corner reflectors (CR) for validation, the accuracy of absolute positioning in 2D is about 7 cm. In 3D, an absolute accuracy of up to ˜ 66 cm is realized, with a cigar-shaped error ellipsoid having centimeter precision in azimuth and range dimensions, and elongated in cross-range dimension with a precision in the order of meters (the ratio of the ellipsoid axis lengths is 1/3/213, respectively). The CR absolute 3D position, along with the associated error ellipsoid, is found to be accurate and agree with the ground truth position at a 99 % confidence level. For other non-CR coherent scatterers, the error ellipsoid concept is validated using 3D building models. In both cases, the error ellipsoid not only serves as a quality descriptor, but can also help to associate radar scatterers to real-world objects.

  9. Toward precision study of atmospheric neutrino oscillations

    Energy Technology Data Exchange (ETDEWEB)

    Kajita, Takaaki [Research Center for Cosmic Neutrinos, Institute for Cosmic Ray Research, Univ. of Tokyo, Kashiwa-no-ha 5-1-5, Kashiwa, Chiba 277-8582 (Japan)

    2006-09-15

    Atmospheric neutrinos have been playing a major role in studying neutrino oscillations. Because of the unique feature of atmospheric neutrinos, future atmospheric neutrino experiments are likely to contribute to precision studies of neutrino oscillations. Possible contribution of future atmospheric neutrino experiments to the neutrino oscillation physics are discussed, including the measurements of {theta}{sub 13}, the sign of {delta}m{sub 23}{sup 2}, the determination of octant of {theta}{sub 23} and possibly the CP phase.

  10. Precision Jet production for the LHC

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    Jet production is one of the basic processes at the LHC with numerous uses for standard model and BSM phenomenology. Understanding this process with suitable precision has been a long-standing goal for the particle physics community. I will report on our recent calculation of the NNLO contribution to jet production using antenna subtraction and discuss what these results might mean for jet phenomenology in the near future.

  11. Needs and challenges in precision wear measurement

    Energy Technology Data Exchange (ETDEWEB)

    Blau, P.J.

    1996-01-10

    Accurate, precise wear measurements are a key element in solving both current wear problems and in basic wear research. Applications range from assessing durability of micro-scale components to accurate screening of surface treatments and thin solid films. Need to distinguish small differences in wear tate presents formidable problems to those who are developing new materials and surface treatments. Methods for measuring wear in ASTM standard test methods are discussed. Errors in using alterate methods of wear measurement on the same test specimen are also described. Human judgemental factors are a concern in common methods for wear measurement, and an experiment involving measurement of a wear scar by ten different people is described. Precision in wear measurement is limited both by the capabilities of the measuring instruments and by the nonuniformity of the wear process. A method of measuring wear using nano-scale indentations is discussed. Current and future prospects for incorporating advanced, higher-precision wear measurement methods into standards are considered.

  12. Precision genome editing in the CRISPR era.

    Science.gov (United States)

    Salsman, Jayme; Dellaire, Graham

    2017-04-01

    With the introduction of precision genome editing using CRISPR-Cas9 technology, we have entered a new era of genetic engineering and gene therapy. With RNA-guided endonucleases, such as Cas9, it is possible to engineer DNA double strand breaks (DSB) at specific genomic loci. DSB repair by the error-prone non-homologous end-joining (NHEJ) pathway can disrupt a target gene by generating insertions and deletions. Alternatively, Cas9-mediated DSBs can be repaired by homology-directed repair (HDR) using an homologous DNA repair template, thus allowing precise gene editing by incorporating genetic changes into the repair template. HDR can introduce gene sequences for protein epitope tags, delete genes, make point mutations, or alter enhancer and promoter activities. In anticipation of adapting this technology for gene therapy in human somatic cells, much focus has been placed on increasing the fidelity of CRISPR-Cas9 and increasing HDR efficiency to improve precision genome editing. In this review, we will discuss applications of CRISPR technology for gene inactivation and genome editing with a focus on approaches to enhancing CRISPR-Cas9-mediated HDR for the generation of cell and animal models, and conclude with a discussion of recent advances and challenges towards the application of this technology for gene therapy in humans.

  13. Mapped Landmark Algorithm for Precision Landing

    Science.gov (United States)

    Johnson, Andrew; Ansar, Adnan; Matthies, Larry

    2007-01-01

    A report discusses a computer vision algorithm for position estimation to enable precision landing during planetary descent. The Descent Image Motion Estimation System for the Mars Exploration Rovers has been used as a starting point for creating code for precision, terrain-relative navigation during planetary landing. The algorithm is designed to be general because it handles images taken at different scales and resolutions relative to the map, and can produce mapped landmark matches for any planetary terrain of sufficient texture. These matches provide a measurement of horizontal position relative to a known landing site specified on the surface map. Multiple mapped landmarks generated per image allow for automatic detection and elimination of bad matches. Attitude and position can be generated from each image; this image-based attitude measurement can be used by the onboard navigation filter to improve the attitude estimate, which will improve the position estimates. The algorithm uses normalized correlation of grayscale images, producing precise, sub-pixel images. The algorithm has been broken into two sub-algorithms: (1) FFT Map Matching (see figure), which matches a single large template by correlation in the frequency domain, and (2) Mapped Landmark Refinement, which matches many small templates by correlation in the spatial domain. Each relies on feature selection, the homography transform, and 3D image correlation. The algorithm is implemented in C++ and is rated at Technology Readiness Level (TRL) 4.

  14. Cost and Precision of Brownian Clocks

    Directory of Open Access Journals (Sweden)

    Andre C. Barato

    2016-12-01

    Full Text Available Brownian clocks are biomolecular networks that can count time. A paradigmatic example are proteins that go through a cycle, thus regulating some oscillatory behavior in a living system. Typically, such a cycle requires free energy often provided by ATP hydrolysis. We investigate the relation between the precision of such a clock and its thermodynamic costs. For clocks driven by a constant thermodynamic force, a given precision requires a minimal cost that diverges as the uncertainty of the clock vanishes. In marked contrast, we show that a clock driven by a periodic variation of an external protocol can achieve arbitrary precision at arbitrarily low cost. This result constitutes a fundamental difference between processes driven by a fixed thermodynamic force and those driven periodically. As a main technical tool, we map a periodically driven system with a deterministic protocol to one subject to an external protocol that changes in stochastic time intervals, which simplifies calculations significantly. In the nonequilibrium steady state of the resulting bipartite Markov process, the uncertainty of the clock can be deduced from the calculable dispersion of a corresponding current.

  15. Cherenkov Detectors for Precision Parity Experiments

    Science.gov (United States)

    Kutz, Tyler; Prex Collaboration; Moller Collaboration

    2017-09-01

    Fused silica Cherenkov detectors are ideal for measuring high-rate fluxes of charged particles. The parity program at Jefferson Lab relies on these detectors to measure cross section asymmetries, some of which are predicted to be on the order of tens of parts per billion. Given the required precision of such experiments, it is important that the resolution of these detectors is minimized. Detectors must be optimized while conforming to the physics and engineering constraints of a specific experiment. Two upcoming JLab experiments that will utilize Cherenkov detectors are the Lead (Pb) Radius EXperiment (PREX) and Measurement Of a Lepton-Lepton Electroweak Reaction (MOLLER). PREX will constrain the neutron equation of state by measuring the neutron skin thickness of 208Pb. MOLLER will test the Standard Model by providing the most precise low-energy measurement of the weak mixing angle. Several detector prototypes have been designed, tested, and simulated to meet the demands of PREX and MOLLER. Presented here is a summary of ongoing work to design state-of-the-art Cherenkov detectors for precision parity experiments.

  16. Ultimate Precision Limits for Noisy Frequency Estimation.

    Science.gov (United States)

    Smirne, Andrea; Kołodyński, Jan; Huelga, Susana F; Demkowicz-Dobrzański, Rafał

    2016-03-25

    Quantum metrology protocols allow us to surpass precision limits typical to classical statistics. However, in recent years, no-go theorems have been formulated, which state that typical forms of uncorrelated noise can constrain the quantum enhancement to a constant factor and, thus, bound the error to the standard asymptotic scaling. In particular, that is the case of time-homogeneous (Lindbladian) dephasing and, more generally, all semigroup dynamics that include phase covariant terms, which commute with the system Hamiltonian. We show that the standard scaling can be surpassed when the dynamics is no longer ruled by a semigroup and becomes time inhomogeneous. In this case, the ultimate precision is determined by the system short-time behavior, which when exhibiting the natural Zeno regime leads to a nonstandard asymptotic resolution. In particular, we demonstrate that the relevant noise feature dictating the precision is the violation of the semigroup property at short time scales, while non-Markovianity does not play any specific role.

  17. Cost and Precision of Brownian Clocks

    Science.gov (United States)

    Barato, Andre C.; Seifert, Udo

    2016-10-01

    Brownian clocks are biomolecular networks that can count time. A paradigmatic example are proteins that go through a cycle, thus regulating some oscillatory behavior in a living system. Typically, such a cycle requires free energy often provided by ATP hydrolysis. We investigate the relation between the precision of such a clock and its thermodynamic costs. For clocks driven by a constant thermodynamic force, a given precision requires a minimal cost that diverges as the uncertainty of the clock vanishes. In marked contrast, we show that a clock driven by a periodic variation of an external protocol can achieve arbitrary precision at arbitrarily low cost. This result constitutes a fundamental difference between processes driven by a fixed thermodynamic force and those driven periodically. As a main technical tool, we map a periodically driven system with a deterministic protocol to one subject to an external protocol that changes in stochastic time intervals, which simplifies calculations significantly. In the nonequilibrium steady state of the resulting bipartite Markov process, the uncertainty of the clock can be deduced from the calculable dispersion of a corresponding current.

  18. Precision respiratory medicine and the microbiome.

    Science.gov (United States)

    Rogers, Geraint B; Wesselingh, Steve

    2016-01-01

    A decade of rapid technological advances has provided an exciting opportunity to incorporate information relating to a range of potentially important disease determinants in the clinical decision-making process. Access to highly detailed data will enable respiratory medicine to evolve from one-size-fits-all models of care, which are associated with variable clinical effectiveness and high rates of side-effects, to precision approaches, where treatment is tailored to individual patients. The human microbiome has increasingly been recognised as playing an important part in determining disease course and response to treatment. Its inclusion in precision models of respiratory medicine, therefore, is essential. Analysis of the microbiome provides an opportunity to develop novel prognostic markers for airways disease, improve definition of clinical phenotypes, develop additional guidance to aid treatment selection, and increase the accuracy of indicators of treatment effect. In this Review we propose that collaboration between researchers and clinicians is needed if respiratory medicine is to replicate the successes of precision medicine seen in other clinical specialties. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. Precise Documentation: The Key to Better Software

    Science.gov (United States)

    Parnas, David Lorge

    The prime cause of the sorry “state of the art” in software development is our failure to produce good design documentation. Poor documentation is the cause of many errors and reduces efficiency in every phase of a software product's development and use. Most software developers believe that “documentation” refers to a collection of wordy, unstructured, introductory descriptions, thousands of pages that nobody wanted to write and nobody trusts. In contrast, Engineers in more traditional disciplines think of precise blueprints, circuit diagrams, and mathematical specifications of component properties. Software developers do not know how to produce precise documents for software. Software developments also think that documentation is something written after the software has been developed. In other fields of Engineering much of the documentation is written before and during the development. It represents forethought not afterthought. Among the benefits of better documentation would be: easier reuse of old designs, better communication about requirements, more useful design reviews, easier integration of separately written modules, more effective code inspection, more effective testing, and more efficient corrections and improvements. This paper explains how to produce and use precise software documentation and illustrate the methods with several examples.

  20. Precision mass measurements of highly charged ions

    Science.gov (United States)

    Kwiatkowski, A. A.; Bale, J. C.; Brunner, T.; Chaudhuri, A.; Chowdhury, U.; Ettenauer, S.; Frekers, D.; Gallant, A. T.; Grossheim, A.; Lennarz, A.; Mane, E.; MacDonald, T. D.; Schultz, B. E.; Simon, M. C.; Simon, V. V.; Dilling, J.

    2012-10-01

    The reputation of Penning trap mass spectrometry for accuracy and precision was established with singly charged ions (SCI); however, the achievable precision and resolving power can be extended by using highly charged ions (HCI). The TITAN facility has demonstrated these enhancements for long-lived (T1/2>=50 ms) isobars and low-lying isomers, including ^71Ge^21+, ^74Rb^8+, ^78Rb^8+, and ^98Rb^15+. The Q-value of ^71Ge enters into the neutrino cross section, and the use of HCI reduced the resolving power required to distinguish the isobars from 3 x 10^5 to 20. The precision achieved in the measurement of ^74Rb^8+, a superallowed β-emitter and candidate to test the CVC hypothesis, rivaled earlier measurements with SCI in a fraction of the time. The 111.19(22) keV isomeric state in ^78Rb was resolved from the ground state. Mass measurements of neutron-rich Rb and Sr isotopes near A = 100 aid in determining the r-process pathway. Advanced ion manipulation techniques and recent results will be presented.

  1. Ultrasound-Assisted Extraction of Stilbenes from Grape Canes.

    Science.gov (United States)

    Piñeiro, Zulema; Marrufo-Curtido, Almudena; Serrano, Maria Jose; Palma, Miguel

    2016-06-16

    An analytical ultrasound-assisted extraction (UAE) method has been optimized and validated for the rapid extraction of stilbenes from grape canes. The influence of sample pre-treatment (oven or freeze-drying) and several extraction variables (solvent, sample-solvent ratio and extraction time between others) on the extraction process were analyzed. The new method allowed the main stilbenes in grape canes to be extracted in just 10 min, with an extraction temperature of 75 °C and 60% ethanol in water as the extraction solvent. Validation of the extraction method was based on analytical properties. The resulting RSDs (n = 5) for interday/intraday precision were less than 10%. Furthermore, the method was successfully applied in the analysis of 20 different grape cane samples. The result showed that grape cane byproducts are potentially sources of bioactive compounds of interest for pharmaceutical and food industries.

  2. Ultrasound-Assisted Extraction of Stilbenes from Grape Canes

    Directory of Open Access Journals (Sweden)

    Zulema Piñeiro

    2016-06-01

    Full Text Available An analytical ultrasound-assisted extraction (UAE method has been optimized and validated for the rapid extraction of stilbenes from grape canes. The influence of sample pre-treatment (oven or freeze-drying and several extraction variables (solvent, sample-solvent ratio and extraction time between others on the extraction process were analyzed. The new method allowed the main stilbenes in grape canes to be extracted in just 10 min, with an extraction temperature of 75 °C and 60% ethanol in water as the extraction solvent. Validation of the extraction method was based on analytical properties. The resulting RSDs (n = 5 for interday/intraday precision were less than 10%. Furthermore, the method was successfully applied in the analysis of 20 different grape cane samples. The result showed that grape cane byproducts are potentially sources of bioactive compounds of interest for pharmaceutical and food industries.

  3. Recent progress in ATLAS top pair cross-sections: from precision measurements to rare processes

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    High-precision top quark pair production cross-section measurements in proton-proton collisions at centre-of-mass energies of 7 and 8 TeV reach a precision of better than 4%, similar to that of recently achieved state-of-art NNLO+NNLL QCD calculations. These benchmark results can be used to extract physical parameters such as the top quark mass or constraints on new physics processes from the comparison between measurement and prediction. Inclusive, differential and fiducial cross section measurements for top pair production are also precision probes of QCD allowing to test latest Monte-Carlo generators. The large Run-1 data sample delivered by the LHC also allows the experiments to explore the production of top pair production in association with bosons.The seminar presents recent ATLAS results on cross-section measurements involving top quark pairs.

  4. Advanced Big Data Analytics for -Omic Data and Electronic Health Records: Toward Precision Medicine.

    Science.gov (United States)

    Wu, Po-Yen; Cheng, Chih-Wen; Kaddi, Chanchala; Venugopalan, Janani; Hoffman, Ryan; Wang, May D

    2016-10-10

    Rapid advances of high-throughput technologies and wide adoption of electronic health records (EHRs) have led to fast accumulation of -omic and EHR data. These voluminous complex data contain abundant information for precision medicine, and big data analytics can extract such knowledge to improve the quality of health care. In this article, we present -omic and EHR data characteristics, associated challenges, and data analytics including data pre-processing, mining, and modeling. To demonstrate how big data analytics enables precision medicine, we provide two case studies, including identifying disease biomarkers from multi-omic data and incorporating -omic information into EHR. Big data analytics is able to address -omic and EHR data challenges for paradigm shift towards precision medicine. Big data analytics makes sense of -omic and EHR data to improve healthcare outcome. It has long lasting societal impact.

  5. -Omic and Electronic Health Record Big Data Analytics for Precision Medicine.

    Science.gov (United States)

    Wu, Po-Yen; Cheng, Chih-Wen; Kaddi, Chanchala D; Venugopalan, Janani; Hoffman, Ryan; Wang, May D

    2017-02-01

    Rapid advances of high-throughput technologies and wide adoption of electronic health records (EHRs) have led to fast accumulation of -omic and EHR data. These voluminous complex data contain abundant information for precision medicine, and big data analytics can extract such knowledge to improve the quality of healthcare. In this paper, we present -omic and EHR data characteristics, associated challenges, and data analytics including data preprocessing, mining, and modeling. To demonstrate how big data analytics enables precision medicine, we provide two case studies, including identifying disease biomarkers from multi-omic data and incorporating -omic information into EHR. Big data analytics is able to address -omic and EHR data challenges for paradigm shift toward precision medicine. Big data analytics makes sense of -omic and EHR data to improve healthcare outcome. It has long lasting societal impact.

  6. Precise measurement of branching ratios in the β decay of 38Ca

    Science.gov (United States)

    Park, H. I.; Hardy, J. C.; Iacob, V. E.; Bencomo, M.; Chen, L.; Horvat, V.; Nica, N.; Roeder, B. T.; McCleskey, E.; Tribble, R. E.; Towner, I. S.

    2015-07-01

    We present the full description of a measurement of the branching ratios for the β decay of 38Ca. This decay includes five allowed 0+→1+ branches and a superallowed 0+→0+ one. With our new result for the latter, we determine its f t value to be 3062.3 ±6.8 s, a result whose precision (0.2%) is comparable to the precision of the 13 well-known 0+→0+ transitions used up until now for the determination of Vud, the up-down quark-mixing element of the Cabibbo-Kobayashi-Maskawa matrix. The 38Ca superallowed transition thus becomes the first addition to this set of transitions in nearly a decade and the first for which a precise mirror comparison is possible, thus enabling an improved test of the isospin-symmetry-breaking corrections required for the extraction of Vud.

  7. Precise measurement of instantaneous volume of eccrine sweat gland in mental sweating by optical coherence tomography

    Science.gov (United States)

    Sugawa, Yoshihiko; Fukuda, Akihiro; Ohmi, Masato

    2015-03-01

    We have demonstrated dynamic analysis of the physiological function of eccrine sweat glands underneath skin surface by optical coherence tomography (OCT). We propose a method for extraction of the target eccrine sweat gland by use of the connected component extraction process and the adaptive threshold method, where the en-face OCT images are constructed by the SS-OCT. Furthermore, we demonstrate precise measurement of instantaneous volume of the sweat gland in response to the external stimulus. The dynamic change of instantaneous volume of eccrine sweat gland in mental sweating is performed by this method during the period of 300 sec with the frame intervals of 3.23 sec.

  8. Should precise numerical dating overrule glacial geomorphology?

    Science.gov (United States)

    Winkler, Stefan

    2016-04-01

    Numerical age dating techniques, namely different types of terrestrial cosmogenic nuclide dating (TCND), have achieved an impressive progress in both laboratory precision and regional calibration models during the past few decades. It is now possible to apply precise TCND even to young landforms like Late Holocene moraines, a task seemed hardly achievable just about 15 years ago. An increasing number of studies provide very precise TCND ages for boulders from Late Holocene moraines enabling related reconstruction of glacier chronologies and the interpretation of these glacial landforms in a palaeoclimatological context. These studies may also solve previous controversies about different ages assigned to moraines obtained by different dating techniques, for example relative-age dating techniques or techniques combining relative-age dating with few fixed points derived from numerical age dating. There are a few cases, for example Mueller Glacier and nearby long debris-covered valley glacier in Aoraki/Mt.Cook National Park (Southern Alps, New Zealand), where the apparent "supremacy" of TCND-ages seem to overrule glacial geomorphological principles. Enabled by a comparatively high number of individual boulders precisely dated by TCND, moraine ridges on those glacier forelands have been primarily clustered on basis of these boulder ages rather than on their corresponding morphological position. To the extreme, segments of a particular moraine complex morphologically and sedimentologically proven to be formed during one event have become split and classified as two separate "moraines" on different parts of the glacier foreland. One ledge of another moraine complex contains 2 TCND-sampled boulders apparently representing two separate "moraines"-clusters of an age difference in the order of 1,500 years. Although recently criticism has been raised regarding the non-contested application of the arithmetic mean for calculation of TCND-ages for individual moraines, this

  9. Development of a monoenergetic ultraslow antiproton beam source for high-precision investigation

    Directory of Open Access Journals (Sweden)

    N. Kuroda

    2012-02-01

    Full Text Available The ASACUSA collaboration developed an ultraslow antiproton beam source, monoenergetic ultraslow antiproton source for high-precision investigation (MUSASHI, consisting of an electromagnetic trap with a liquid He free superconducting solenoid and a low energy antiproton beam transport line. The MUSASHI was capable of trapping and cooling more than 1×10^{7} antiprotons and extracting them as an ultraslow antiproton beam with energy of 150–250 eV.

  10. Precise branching ratios from β-γ coincidences: the case of ^^34Ar.

    Science.gov (United States)

    Iacob, V. E.; Hardy, J. C.; Golovko, V.

    2007-04-01

    The experiment reported here aims to extract a precise ft-value for the superallowed 0^+->0^+ β^+-decay of ^^34Ar. Such measurements are essential in testing the Standard Model via the unitarity of the Cabibbo-Kobayashi-Maskawa matrix. One ingredient in the ft-value is the branching ratio and, to be useful, it must be determined with a precision of ˜0.1% or better. Since the β^+-decay of ^^34Ar populates the ground-state as well as excited states of the ^3^34Cl daughter, to determine the branching ratio, we require β-γ coincidences as well as β singles, both with well determined intensities. Gammas were measured with our precisely calibrated HPGe detector whose absolute efficiency is known to 0.2% for energies between 50 and 1400 keV and to 0.4% from 1400 to 3500 keV. For the β detector we also require accurate relative efficiencies. To this end, we have compared the recorded beta spectra -- in singles and in coincidence with individual γ-ray peaks -- with Monte Carlo calculations performed with the DOSRZNRC program (from the EGS package) [1]. Good agreement was obtained over a wide energy range, allowing us to extract precise branching-ratio results. [1] NRCC Report PIRS-701 and http://www.irs.inms.nrc.ca/inms/irs/EGSnrc/EGSnrc.html

  11. Higgs-precision constraints on colored naturalness

    Science.gov (United States)

    Essig, Rouven; Meade, Patrick; Ramani, Harikrishnan; Zhong, Yi-Ming

    2017-09-01

    The presence of weak-scale colored top partners is among the simplest solutions to the Higgs hierarchy problem and allows for a natural electroweak scale. We examine the constraints on generic colored top partners coming solely from their effect on the production and decay rates of the observed Higgs with a mass of 125 GeV. We use the latest Higgs precision data from the Tevatron and the LHC as of EPS 2017 to derive the current limits on spin-0, spin-1/2, and spin-1 colored top partners. We also investigate the expected sensitivity from the Run 3 and Run 4 of the LHC, as well from possible future electron-positron and proton-proton colliders, including the ILC, CEPC, FCC-ee, and FCC-hh. We discuss constraints on top partners in the Minimal Supersymmetric Standard Model and Little Higgs theories. We also consider various model-building aspects — multiple top partners, modified couplings between the Higgs and Standard-Model particles, and non-Standard-Model Higgs sectors — and evaluate how these weaken the current limits and expected sensitivities. By modifying other Standard-Model Higgs couplings, we find that the best way to hide low-mass top partners from current data is through modifications of the top-Yukawa coupling, although future measurements of top-quark-pair production in association with a Higgs will extensively probe this possibility. We also demonstrate that models with multiple top partners can generically avoid current and future Higgs precision measurements. Nevertheless, some of the model parameter space can be probed with precision measurements at future electron-positron colliders of, for example, the e + e - → Zhcrosssection.

  12. High precision kinematic surveying with laser scanners

    Science.gov (United States)

    Gräfe, Gunnar

    2007-12-01

    The kinematic survey of roads and railways is becoming a much more common data acquisition method. The development of the Mobile Road Mapping System (MoSES) has reached a level that allows the use of kinematic survey technology for high precision applications. The system is equipped with cameras and laser scanners. For high accuracy requirements, the scanners become the main sensor group because of their geometric precision and reliability. To guarantee reliable survey results, specific calibration procedures have to be applied, which can be divided into the scanner sensor calibration as step 1, and the geometric transformation parameter estimation with respect to the vehicle coordinate system as step 2. Both calibration steps include new methods for sensor behavior modeling and multisensor system integration. To verify laser scanner quality of the MoSES system, the results are regularly checked along different test routes. It can be proved that a standard deviation of 0.004 m for height of the scanner points will be obtained, if the specific calibrations and data processing methods are applied. This level of accuracy opens new possibilities to serve engineering survey applications using kinematic measurement techniques. The key feature of scanner technology is the full digital coverage of the road area. Three application examples illustrate the capabilities. Digital road surface models generated from MoSES data are used, especially for road surface reconstruction tasks along highways. Compared to static surveys, the method offers comparable accuracy at higher speed, lower costs, much higher grid resolution and with greater safety. The system's capability of gaining 360 profiles leads to other complex applications like kinematic tunnel surveys or the precise analysis of bridge clearances.

  13. Precision of working memory for speech sounds.

    Science.gov (United States)

    Joseph, Sabine; Iverson, Paul; Manohar, Sanjay; Fox, Zoe; Scott, Sophie K; Husain, Masud

    2015-01-01

    Memory for speech sounds is a key component of models of verbal working memory (WM). But how good is verbal WM? Most investigations assess this using binary report measures to derive a fixed number of items that can be stored. However, recent findings in visual WM have challenged such "quantized" views by employing measures of recall precision with an analogue response scale. WM for speech sounds might rely on both continuous and categorical storage mechanisms. Using a novel speech matching paradigm, we measured WM recall precision for phonemes. Vowel qualities were sampled from a formant space continuum. A probe vowel had to be adjusted to match the vowel quality of a target on a continuous, analogue response scale. Crucially, this provided an index of the variability of a memory representation around its true value and thus allowed us to estimate how memories were distorted from the original sounds. Memory load affected the quality of speech sound recall in two ways. First, there was a gradual decline in recall precision with increasing number of items, consistent with the view that WM representations of speech sounds become noisier with an increase in the number of items held in memory, just as for vision. Based on multidimensional scaling (MDS), the level of noise appeared to be reflected in distortions of the formant space. Second, as memory load increased, there was evidence of greater clustering of participants' responses around particular vowels. A mixture model captured both continuous and categorical responses, demonstrating a shift from continuous to categorical memory with increasing WM load. This suggests that direct acoustic storage can be used for single items, but when more items must be stored, categorical representations must be used.

  14. Development of inconel alloys precision tube

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young-Hee; Lee, D. H.; Shin, Y. S.; Park, J. H. [Changwon Speciality Steel Co., Ltd., Changwon (Korea); Kim, J. S.; Kim, H. P; Lim, Y. S.; Hwang, S. S.; Jung, M. K.; Woo, Y. M.; Han, C. H. [Korea Atomic Energy Research Institute, Taejeon (Korea)

    1998-04-01

    The purpose of this research is to investigate the mass production facility and evaluation of profitability for steam generator tubing in nuclear power plant. The equipment requirement and capacity, total investment cost, the evaluation of mass production yield and production cost accounting, the manufacturing technique standardization have been investigated. According to the result of evaluation of profitability, the project for SG tubing will be difficult to commercialize, but it can be considered the re-commercialize when the condition for investment is improving. The results of this research can be applicated to commercialize the precision tubes manufacturing which require similar process. 17 refs., 7 figs., 21 tabs. (Author)

  15. Precision cosmology as a neutrino laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Wong, Yvonne Y.Y. [Institut fuer Theoretische Teilchenphysik und Kosmologie, RWTH Aachen, D-52056 Aachen (Germany)

    2012-08-15

    I give an overview of the effects of neutrinos on cosmology, focussing in particular on the role played by massive neutrinos in the evolution of cosmological perturbations. I discuss how recent observations of the cosmic microwave background anisotropies and the large-scale structure of galaxies can probe neutrino masses with greater precision than current laboratory experiments. I describe several new techniques that will be used to probe cosmology in the future, and also some recent advances in the computation of the nonlinear matter power spectrum and related observables.

  16. Selected Highlights from Precision Studies in ATLAS

    CERN Document Server

    Beck, Hans Peter; The ATLAS collaboration

    2014-01-01

    Recent highlights on precision measurements in proton-proton collisions at 7 and 8 TeV with the ATLAS detector are presented: the production cross section of jets, W and Z bosons, multi-bosons and top quark pairs, as well as single top production. Furthermore, the production of W and Z bosons and top quarks in association with jets is discussed and compared to state-of-art theory calculations. The latest measurements of the top quark mass and other properties, together with Standard Model parameters, will be reviewed.

  17. Lasers the power and precision of light

    CERN Document Server

    Diels, Jean-Claude

    2011-01-01

    ""Lasers"" are active ingredients of our modern life, but they are inconspicuous as they often go unnoticed. This intuitive introductory guide will tell you all you want to know about laser technologies in very diverse fields from nuclear and particle physics to medicine, astronomy and ultra-precise metrology. The book is coherently focused on fundamentals, and is aimed to stimulate intuition about present and future applications, while unveiling the halo of myths around lasers. Written by reputable laser experts who think that science should be entertaining, this useful reference relies on si

  18. Static quarks with improved statistical precision

    CERN Document Server

    Della Morte, M; Heitger, J; Molke, H; Rolf, J; Shindler, A; Sommer, R

    2003-01-01

    We present a numerical study for different discretisations of the static action, concerning cut-off effects and the growth of statistical errors with Euclidean time. An error reduction by an order of magnitude can be obtained with respect to the Eichten-Hill action, for time separations up to 2 fm, keeping discretization errors small. The best actions lead to a big improvement on the precision of the quark mass M sub b and F sub B sub sub s in the static approximation.

  19. Precision Mass Measurement of Argon Isotopes

    CERN Multimedia

    Lunney, D

    2002-01-01

    % IS388\\\\ \\\\ A precision mass measurement of the neutron-deficient isotopes $^{32,33,34}$Ar is proposed. Mass values of these isotopes are of importance for: a) a stringent test of the Isobaric-Multiplet- Mass-Equation, b) a verification of the correctness of calculated charge-dependent corrections as used in super-allowed $\\beta$- decay studies aiming at a test of the CVC hypothesis, and c) the determination of the kinematics in electron-neutrino correlation experiments searching for scalar currents in weak interaction. The measurements will be carried out with the ISOLTRAP Penning trap mass spectrometer.

  20. Transmission media effects on precise Doppler tracking

    Science.gov (United States)

    Callahan, P. S.

    1978-01-01

    The effects of the transmission media - the earth's troposphere and ionosphere, and the solar wind - on precise Doppler tracking are discussed. The charged particle effects can be largely removed by dual frequency observations; however there are limitations to these corrections (besides system noise and/or finite integration times) including the effects of magnetic fields, diffraction, and differential refraction, all of which must be carefully evaluated. The earth's troposphere can contribute an error of delta f/f approximately 10 to the minus 14th power.

  1. Qualification of a precision pattern dispenser.

    Science.gov (United States)

    Van Ammel, Raf; Sobiech-Matura, Katarzyna; Wätjen, Uwe; Vercammen, Tom; Castelein, Pieter; Wuyts, Roel; Paul, Johan

    2017-06-16

    In order to automate sample preparation processes, a precision pattern dispenser was designed to reproducibly dispense radioactive solutions at pre-defined positions. It is composed of an automatic liquid sample handling unit coupled to an XYZ table. Qualification tests were conducted to evaluate the performance of the instrument and to assess the compliance with the requirements, in particular trueness (< 2%) and repeatability (< 1%). The instrument allows preparing sources in different source holders and on air filters, in a fast and accurate way. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  2. Physicists of Ireland passion and precision

    CERN Document Server

    McCartney, Mark

    2003-01-01

    Demonstrating the strength of tradition in Ireland, Physicists of Ireland: Passion and Precision is a collection of essays on leading figures from the history of physics in Ireland. It includes physicists born outside of Ireland who carried out significant work in Ireland as well as those who had strong Irish roots but carried out their work outside of Ireland. The book is well illustrated with diagrams and photos of historical interest and rounded off with useful suggestions for further reading. It might come as a surprise to many that several leading English physicists are actually from Ireland.

  3. Establishing precision and accuracy in PDV results

    Energy Technology Data Exchange (ETDEWEB)

    Briggs, Matthew E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Howard, Marylesa [National Security Technologies, LLC. (NSTec), North Las Vegas, NV (United States); Diaz, Abel [National Security Technologies, LLC. (NSTec), Los Alamos, NM (United States)

    2016-04-19

    We need to know uncertainties and systematic errors because we create and compare against archival weapons data, we constrain the models, and we provide scientific results. Good estimates of precision from the data record are available and should be incorporated into existing results; reanalysis of valuable data is suggested. Estimates of systematic errors are largely absent. The original work by Jensen et al. using gun shots for window corrections, and the integrated velocity comparison with X-rays by Schultz are two examples where any systematic errors appear to be <1% level.

  4. Genetic Mutations and Epigenetic Modifications: Driving Cancer and Informing Precision Medicine

    Directory of Open Access Journals (Sweden)

    Krysta Mila Coyle

    2017-01-01

    Full Text Available Cancer treatment is undergoing a significant revolution from “one-size-fits-all” cytotoxic therapies to tailored approaches that precisely target molecular alterations. Precision strategies for drug development and patient stratification, based on the molecular features of tumors, are the next logical step in a long history of approaches to cancer therapy. In this review, we discuss the history of cancer treatment from generic natural extracts and radical surgical procedures to site-specific and combinatorial treatment regimens, which have incrementally improved patient outcomes. We discuss the related contributions of genetics and epigenetics to cancer progression and the response to targeted therapies and identify challenges and opportunities for the success of precision medicine. The identification of patients who will benefit from targeted therapies is more complex than simply identifying patients whose tumors harbour the targeted aberration, and intratumoral heterogeneity makes it difficult to determine if a precision therapy is successful during treatment. This heterogeneity enables tumors to develop resistance to targeted approaches; therefore, the rational combination of therapeutic agents will limit the threat of acquired resistance to therapeutic success. By incorporating the view of malignant transformation modulated by networks of genetic and epigenetic interactions, molecular strategies will enable precision medicine for effective treatment across cancer subtypes.

  5. Fabrication for precision mechanisms. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Gillespie, L.K.

    1980-03-01

    The fabrication of components and assemblies for miniature precision mechanisms provides a variety of exacting manufacturing challenges. Size alone makes many parts hard to pick up, handle, measure, and install. This same small size causes more distortion or bending during machining, assembly, and welding. Some parts even float on the cleaning and deburring solutions. Tools break easily in very small holes, and surface finishes play an important role in part operation. Twenty-five manufacturing operations were studied to improve the precision of existing machining and assembly techniques. The study included the machining of metals and plastics using techniques new to the manufacture of miniature switches, timers, and actuators. Drilling, tapping, and press-fitting miniature features were evaluated. Fixturing and handling techniques, friction reduction, and the forming of ceramic parts were also studied. Many of the new approaches from this study have been incorporated into existing processes and further refined. Detailed observations have been reported in 33 other Bendix reports and the highlights of those observations are summarized in this study.

  6. Structurally uniform and atomically precise carbon nanostructures

    Science.gov (United States)

    Segawa, Yasutomo; Ito, Hideto; Itami, Kenichiro

    2016-01-01

    Nanometre-sized carbon materials consisting of benzene units oriented in unique geometric patterns, hereafter named nanocarbons, conduct electricity, absorb and emit light, and exhibit interesting magnetic properties. Spherical fullerene C60, cylindrical carbon nanotubes and sheet-like graphene are representative forms of nanocarbons, and theoretical simulations have predicted several exotic 3D nanocarbon structures. At present, synthetic routes to nanocarbons mainly lead to mixtures of molecules with a range of different structures and properties, which cannot be easily separated or refined into pure forms. Some researchers believe that it is impossible to synthesize these materials in a precise manner. Obtaining ‘pure’ nanocarbons is a great challenge in the field of nanocarbon science, and the construction of structurally uniform nanocarbons, ideally as single molecules, is crucial for the development of functional materials in nanotechnology, electronics, optics and biomedical applications. This Review highlights the organic chemistry approach — more specifically, bottom-up construction with atomic precision — that is currently the most promising strategy towards this end.

  7. Precision measurements of rare kaon decays

    CERN Document Server

    Marinova, Evelina

    2009-01-01

    We report the latest results on rare kaon decays from the NA48/2 experiment. Samples of about 7200 reconstructed K+- -> pi+- e+ e-, and more than 3000 K+- -> pi+- mu+ mu- events, with very small background contamination, have been collected. The latter is exceeding the total existing statistics by a factor of five. A precise measurement of the branching fractions and the form factors of the rare decays K+- -> pi+- l+ l- has been performed using different theoretical models. The precise measurement of direct photon emission (DE) in the decay K+- -> pi+- pi0 gamma and its interference (INT), with the INT amplitude being observed for the first time, has been finalized. This study is based on the full NA48/2 data set with about 600k reconstructed K+- -> pi+- pi0 gamma decays which is factor of 30 larger than for previous experiments. We report the results on the CP violating asymmetry between K+ and K- obtained from rare kaon decays

  8. Rapid and precise genotyping of porcine microsatellites.

    Science.gov (United States)

    Yue, G H; Beeckmann, P; Bartenschlager, H; Moser, G; Geldermann, H

    1999-11-01

    Microsatellites are useful markers for genetic mapping and linkage analysis because they are highly polymorphic, abundant in genomes and relatively easily scored with polymerase chain reaction (PCR). A rapid genotyping system for microsatellites was developed, which included multiplex PCRs, multiple use of Hydrolink gels, automated fluorescent detection of fragments on an A.L.F. DNA sequencer, automatic assignment of alleles to each locus and verification of genotypes with a self-developed computer program "Fragtest". Eight multiplex PCRs have been developed to genotype 29 microsatellites for genetic and quantitative trait loci (QTL) mapping on pig chromosomes 6, 7, 12 and 13. Three to six microsatellites could be amplified in one multiplex PCR. Each multiplex reaction required only different concentrations of each pair of primers and a low concentration of dNTP (100 microM). A dNTP concentration of 100 microM proved to be optimal for the coamplification of microsatellites under the concentration of 1.5 mM MgCl2. Using four internal size standards added in each sample, the 5% Hydrolink gel could subsequently be used up to five times (total running time of 500 min) on the A.L.F. automated sequencer without significant loss of resolution and precision of fragment length analysis. Automatic assignment of alleles on each locus using "Fragtest" significantly increased the efficiency and precision of the genotyping. This system is thus a rapid, cheap, and highly discriminating genotyping system.

  9. Thermoforming mechanism of precision glass moulding.

    Science.gov (United States)

    Liu, Weidong; Zhang, Liangchi

    2015-08-01

    Precision glass moulding (PGM) enables the production of an aspherical lens and irregular optical products in a single step, but its product quality depends highly on the control of both material properties and process parameters. This paper investigates the thermoforming mechanism of a glass lens in PGM. To precisely describe the material behavior in PGM, a modulus-based constitutive model was framed and integrated with the finite element analysis. This model can be parameterized conveniently by an impulse excitation technique. Key processing parameters that influence the final profile and residual stresses of a lens were identified with the aid of dimensional analysis. The study found that the cooling stage above the glass transition temperature can bring about large geometry deviations of a lens. The residual stresses in a lens depend mainly on the temperature history in the supercooled liquid region caused by the variability and heterogeneity of thermal expansion. However, the stresses can be reduced effectively by decreasing the cooling rate from moulding temperature to glass transition temperature.

  10. Golden Jubilee photos: Precision is their motto

    CERN Multimedia

    2004-01-01

    At the beginning of the 1980s, CERN embarked on the enormous Large Electron-Positron Collider construction project. The excavation of the 27-kilometre LEP tunnel was a huge technical challenge. The tunnel-boring machines excavated the tunnel in 3.3 km octants and had to be operated with extraordinary precision to ensure that they reached their destination - the bottom of the next vertical shaft - precisely on target. The tunnel was excavated before high-performance instruments were developed for the construction of the Channel Tunnel. As no firms were willing to perform the surveying work, CERN's own surveyors, with experience from the SPS behind them, took up the challenge. At the surface, the surveyors established the world's most accurate geodetic network, performing measurements to an accuracy of 10-7, or 1mm per 10 km, using the Terrameter (see photo). The excavation of the tunnel was completed in 1988 and the finished tunnel's trajectory was found to diverge from the theoretical value specified by the...

  11. Soviet precision timekeeping research and technology

    Energy Technology Data Exchange (ETDEWEB)

    Vessot, R.F.C.; Allan, D.W.; Crampton, S.J.B.; Cutler, L.S.; Kern, R.H.; McCoubrey, A.O.; White, J.D.

    1991-08-01

    This report is the result of a study of Soviet progress in precision timekeeping research and timekeeping capability during the last two decades. The study was conducted by a panel of seven US scientists who have expertise in timekeeping, frequency control, time dissemination, and the direct applications of these disciplines to scientific investigation. The following topics are addressed in this report: generation of time by atomic clocks at the present level of their technology, new and emerging technologies related to atomic clocks, time and frequency transfer technology, statistical processes involving metrological applications of time and frequency, applications of precise time and frequency to scientific investigations, supporting timekeeping technology, and a comparison of Soviet research efforts with those of the United States and the West. The number of Soviet professionals working in this field is roughly 10 times that in the United States. The Soviet Union has facilities for large-scale production of frequency standards and has concentrated its efforts on developing and producing rubidium gas cell devices (relatively compact, low-cost frequency standards of modest accuracy and stability) and atomic hydrogen masers (relatively large, high-cost standards of modest accuracy and high stability). 203 refs., 45 figs., 9 tabs.

  12. Precision genome engineering in lactic acid bacteria.

    Science.gov (United States)

    van Pijkeren, Jan Peter; Britton, Robert A

    2014-08-29

    Innovative new genome engineering technologies for manipulating chromosomes have appeared in the last decade. One of these technologies, recombination mediated genetic engineering (recombineering) allows for precision DNA engineering of chromosomes and plasmids in Escherichia coli. Single-stranded DNA recombineering (SSDR) allows for the generation of subtle mutations without the need for selection and without leaving behind any foreign DNA. In this review we discuss the application of SSDR technology in lactic acid bacteria, with an emphasis on key factors that were critical to move this technology from E. coli into Lactobacillus reuteri and Lactococcus lactis. We also provide a blueprint for how to proceed if one is attempting to establish SSDR technology in a lactic acid bacterium. The emergence of CRISPR-Cas technology in genome engineering and its potential application to enhancing SSDR in lactic acid bacteria is discussed. The ability to perform precision genome engineering in medically and industrially important lactic acid bacteria will allow for the genetic improvement of strains without compromising safety.

  13. Precision global health in the digital age.

    Science.gov (United States)

    Flahault, Antoine; Geissbuhler, Antoine; Guessous, Idris; Guérin, Philippe; Bolon, Isabelle; Salathé, Marcel; Escher, Gérard

    2017-04-19

    Precision global health is an approach similar to precision medicine, which facilitates, through innovation and technology, better targeting of public health interventions on a global scale, for the purpose of maximising their effectiveness and relevance. Illustrative examples include: the use of remote sensing data to fight vector-borne diseases; large databases of genomic sequences of foodborne pathogens helping to identify origins of outbreaks; social networks and internet search engines for tracking communicable diseases; cell phone data in humanitarian actions; drones to deliver healthcare services in remote and secluded areas. Open science and data sharing platforms are proposed for fostering international research programmes under fair, ethical and respectful conditions. Innovative education, such as massive open online courses or serious games, can promote wider access to training in public health and improving health literacy. The world is moving towards learning healthcare systems. Professionals are equipped with data collection and decision support devices. They share information, which are complemented by external sources, and analysed in real time using machine learning techniques. They allow for the early detection of anomalies, and eventually guide appropriate public health interventions. This article shows how information-driven approaches, enabled by digital technologies, can help improving global health with greater equity.

  14. Multineuronal Spike Sequences Repeat with Millisecond Precision

    Directory of Open Access Journals (Sweden)

    Koki eMatsumoto

    2013-06-01

    Full Text Available Cortical microcircuits are nonrandomly wired by neurons. As a natural consequence, spikes emitted by microcircuits are also nonrandomly patterned in time and space. One of the prominent spike organizations is a repetition of fixed patterns of spike series across multiple neurons. However, several questions remain unsolved, including how precisely spike sequences repeat, how the sequences are spatially organized, how many neurons participate in sequences, and how different sequences are functionally linked. To address these questions, we monitored spontaneous spikes of hippocampal CA3 neurons ex vivo using a high-speed functional multineuron calcium imaging technique that allowed us to monitor spikes with millisecond resolution and to record the location of spiking and nonspiking neurons. Multineuronal spike sequences were overrepresented in spontaneous activity compared to the statistical chance level. Approximately 75% of neurons participated in at least one sequence during our observation period. The participants were sparsely dispersed and did not show specific spatial organization. The number of sequences relative to the chance level decreased when larger time frames were used to detect sequences. Thus, sequences were precise at the millisecond level. Sequences often shared common spikes with other sequences; parts of sequences were subsequently relayed by following sequences, generating complex chains of multiple sequences.

  15. The precise temporal calibration of dinosaur origins

    Science.gov (United States)

    Marsicano, Claudia A.; Irmis, Randall B.; Mancuso, Adriana C.; Mundil, Roland; Chemale, Farid

    2016-01-01

    Dinosaurs have been major components of ecosystems for over 200 million years. Although different macroevolutionary scenarios exist to explain the Triassic origin and subsequent rise to dominance of dinosaurs and their closest relatives (dinosauromorphs), all lack critical support from a precise biostratigraphically independent temporal framework. The absence of robust geochronologic age control for comparing alternative scenarios makes it impossible to determine if observed faunal differences vary across time, space, or a combination of both. To better constrain the origin of dinosaurs, we produced radioisotopic ages for the Argentinian Chañares Formation, which preserves a quintessential assemblage of dinosaurian precursors (early dinosauromorphs) just before the first dinosaurs. Our new high-precision chemical abrasion thermal ionization mass spectrometry (CA-TIMS) U-Pb zircon ages reveal that the assemblage is early Carnian (early Late Triassic), 5- to 10-Ma younger than previously thought. Combined with other geochronologic data from the same basin, we constrain the rate of dinosaur origins, demonstrating their relatively rapid origin in a less than 5-Ma interval, thus halving the temporal gap between assemblages containing only dinosaur precursors and those with early dinosaurs. After their origin, dinosaurs only gradually dominated mid- to high-latitude terrestrial ecosystems millions of years later, closer to the Triassic-Jurassic boundary.

  16. High precision innovative micropump for artificial pancreas

    Science.gov (United States)

    Chappel, E.; Mefti, S.; Lettieri, G.-L.; Proennecke, S.; Conan, C.

    2014-03-01

    The concept of artificial pancreas, which comprises an insulin pump, a continuous glucose meter and a control algorithm, is a major step forward in managing patient with type 1 diabetes mellitus. The stability of the control algorithm is based on short-term precision micropump to deliver rapid-acting insulin and to specific integrated sensors able to monitor any failure leading to a loss of accuracy. Debiotech's MEMS micropump, based on the membrane pump principle, is made of a stack of 3 silicon wafers. The pumping chamber comprises a pillar check-valve at the inlet, a pumping membrane which is actuated against stop limiters by a piezo cantilever, an anti-free-flow outlet valve and a pressure sensor. The micropump inlet is tightly connected to the insulin reservoir while the outlet is in direct communication with the patient skin via a cannula. To meet the requirement of a pump dedicated to closed-loop application for diabetes care, in addition to the well-controlled displacement of the pumping membrane, the high precision of the micropump is based on specific actuation profiles that balance effect of pump elasticity in low-consumption push-pull mode.

  17. High precision laser photometer for laser optics

    Science.gov (United States)

    Zhao, Yuan'an; Hu, Guohang; Cao, Zhen; Liu, Shijie; Zhu, Meiping; Shao, Jianda

    2017-06-01

    Development of laser systems requires optical components with high performance, and a high-precision double-beam laser photometer was designed and established to measure the optical performance at 1064nm. Double beam design and lock-in technique was applied to decrease the impact of light energy instability and electric noise. Pairs of samples were placed symmetrically to eliminate beam displacement, and laser scattering imaging technique was applied to determine the influence of surface defect on the optical performance. Based on the above techniques, transmittance and reflection of pairs of optics were obtained, and the measurement precision was improved to 0.06%. Different types of optical loss, such as total loss, volume loss, residual reflection and surface scattering loss, were obtained from the transmittance and reflection measurement of samples with different thickness. Comparison of optical performance of the test points with and without surface defects, the influence of surface defects on optical performance was determined. The optical performance of Nd-glass at 1064nm were measured as an example. Different types of optical loss and the influence of surface defects on the optical loss was determined.

  18. Surviving With Smog and Smoke: Precision Interventions?

    Science.gov (United States)

    Cai, Hua; Wang, Chen

    2017-11-01

    Despite continuous efforts of regional governmental agencies, air pollution remains a major threat to public health worldwide. In January 2017, a severe episode of smog similar to the Great Smog of 1952 occurred in London. The longest episode of Chinese haze also developed in Beijing, during which levels of particulate matter smoke. For countries with large populations of smokers, such as China, India, the United States, and Russia, surviving both smog and smoke is a serious problem. With novel genomic and epigenomic studies revealing air pollution- and smoking-induced mutational signatures and epigenetic editing in diseases such as lung cancer, it has become feasible to develop precision strategies for early intervention in the disease-causing pathways driven by the specific mutations or epigenetic regulations, or both. New therapies guided by gene-drug interactions and genomic biomarkers may also be developed. We discuss both perspectives regarding the urgent need to manage the toxic effects of smog and smoke for the benefit of global health and the novel concept of precision intervention to protect the exposed individuals when exposure to smog and secondhand smoke cannot be voluntarily avoided or easily modified. Copyright © 2017 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

  19. Precision wildlife medicine: applications of the human-centred precision medicine revolution to species conservation.

    Science.gov (United States)

    Whilde, Jenny; Martindale, Mark Q; Duffy, David J

    2017-05-01

    The current species extinction crisis is being exacerbated by an increased rate of emergence of epizootic disease. Human-induced factors including habitat degradation, loss of biodiversity and wildlife population reductions resulting in reduced genetic variation are accelerating disease emergence. Novel, efficient and effective approaches are required to combat these epizootic events. Here, we present the case for the application of human precision medicine approaches to wildlife medicine in order to enhance species conservation efforts. We consider how the precision medicine revolution, coupled with the advances made in genomics, may provide a powerful and feasible approach to identifying and treating wildlife diseases in a targeted, effective and streamlined manner. A number of case studies of threatened species are presented which demonstrate the applicability of precision medicine to wildlife conservation, including sea turtles, amphibians and Tasmanian devils. These examples show how species conservation could be improved by using precision medicine techniques to determine novel treatments and management strategies for the specific medical conditions hampering efforts to restore population levels. Additionally, a precision medicine approach to wildlife health has in turn the potential to provide deeper insights into human health and the possibility of stemming and alleviating the impacts of zoonotic diseases. The integration of the currently emerging Precision Medicine Initiative with the concepts of EcoHealth (aiming for sustainable health of people, animals and ecosystems through transdisciplinary action research) and One Health (recognizing the intimate connection of humans, animal and ecosystem health and addressing a wide range of risks at the animal-human-ecosystem interface through a coordinated, collaborative, interdisciplinary approach) has great potential to deliver a deeper and broader interdisciplinary-based understanding of both wildlife and human

  20. Precision QCD measurements in DIS at HERA

    Science.gov (United States)

    Britzger, Daniel

    2016-08-01

    New and recent results on QCD measurements from the H1 and ZEUS experiments at the HERA ep collider are reviewed. The final results on the combined deep-inelastic neutral and charged current cross-sections are presented and their role in the extractions of parton distribution functions (PDFs) is studied. The PDF fits give insight into the compatibility of QCD evolution and heavy flavor schemes with the data as a function of kinematic variables such as the scale Q2. Measurements of jet production cross-sections in ep collisions provide direct proves of QCD and extractions of the strong coupling constants are performed. Charm and beauty cross-section measurements are used for the determination of the heavy quark masses. Their role in PDF fits is investigated. In the regime of diffractive DIS and photoproduction, dijet and prompt photon production cross-sections provide insights into the process of factorization and the nature of the diffractive exchange.

  1. Precise measurement of magnetic field gradients from free spin precession signals of He-3 and Xe-129 magnetometers

    NARCIS (Netherlands)

    Allmendinger, Fabian; Blümler, Peter; Doll, Michael; Grasdijk, Oliver; Heil, Werner; Jungmann, Klaus; Karpuk, Sergej; Krause, Hans-Joachim; Offenhäuser, Andreas; Repetto, Maricel; Schmidt, Ulrich; Sobolev, Yuri; Tullney, Kathlyne; Willmann, Lorenz; Zimmer, Stefan

    2017-01-01

    We report on precise measurements of magnetic field gradients extracted from transverse relaxation rates of precessing spin samples. The experimental approach is based on the free precession of gaseous, nuclear spin polarized He-3 and (12)9Xe atoms in a spherical cell inside a magnetic guiding field

  2. Unsupervised Learning of mDTD Extraction Patterns for Web Text Mining.

    Science.gov (United States)

    Kim, Dongseok; Jung, Hanmin; Lee, Gary Geunbae

    2003-01-01

    Presents a new extraction pattern, modified Document Type Definition (mDTD), which relies on analytical interpretation to identify extraction target from the contents of Web documents. Experiments with 330 Korean and 220 English Web documents on audio and video shopping sites yielded an average extraction precision of 91.3% for Korean and 81.9%…

  3. Atomic physics precise measurements and ultracold matter

    CERN Document Server

    Inguscio, Massimo

    2013-01-01

    Atomic Physics provides an expert guide to two spectacular new landscapes in physics: precision measurements, which have been revolutionized by the advent of the optical frequency comb, and atomic physics, which has been revolutionized by laser cooling. These advances are not incremental but transformative: they have generated a consilience between atomic and many-body physics, precipitated an explosion of scientific and technological applications, opened new areas of research, and attracted a brilliant generation of younger scientists. The research is advancing so rapidly, the barrage of applications is so dazzling, that students can be bewildered. For both students and experienced scientists, this book provides an invaluable description of basic principles, experimental methods, and scientific applications.

  4. Precise documentation of well-structured programs

    Energy Technology Data Exchange (ETDEWEB)

    Parnas, D.L.; Madey, J.; Iglewski, M. [McMaster Univ., Hamilton, Ontario (Canada)

    1997-11-01

    This paper describes a new form of program documentation that is precise, systematic and readable. This documentation comprises a set of displays supplemented by a lexicon and an index. Each display presents a program fragment in such a way that its correctness can be examined without looking at any other display. Each display has three parts: (1) the specification of the program presented in the display, (2) the program itself, and (3) the specifications of programs invoked by this program. The displays are intended to be used by Software Engineers as a reference document during inspection and maintenance. This paper also introduces a specification technique that is a refinement of Mills functional approach to program documentation and verification; programs are specified and described in tabular form.

  5. Micropropulsion Systems for Precision Controlled Space Flight

    DEFF Research Database (Denmark)

    Larsen, Jack

    Space science is subject to a constantly increasing demand for larger coherence lengths or apertures of the space observation systems, which in turn translates into a demand for increased dimensions and subsequently cost and complexity of the systems. When this increasing demand reaches...... the pratical limitations of increasing the physical dimensions of the spacecrafts, the observation platforms will have to be distributed on more spacecrafts flying in very accurate formations. Consequently, the observation platform becomes much more sensitive to disturbances from the space environment....... This project is thus concentrating on developing a method by which an entire, ecient, control system compensating for the disturbances from the space environment and thereby enabling precision formation flight can be realized. The space environment is initially studied and the knowledge gained is used...

  6. Fundamental cosmology from precision spectroscopy: Varying couplings

    Science.gov (United States)

    Leite, A. C. O.; Martins, C. J. A. P.; Pedrosa, P. O. J.; Nunes, N. J.

    2014-09-01

    The observational evidence for the acceleration of the Universe demonstrates that canonical theories of cosmology and particle physics are incomplete, if not incorrect, and that new physics is out there, waiting to be discovered. Forthcoming high-resolution ultrastable spectrographs will play a crucial role in this quest for new physics, by enabling a new generation of precision consistency tests. Here we focus on astrophysical tests of the stability of nature's fundamental couplings, and by using principal component analysis techniques further calibrated by existing VLT data we discuss how the improvements that can be expected with ESPRESSO and ELT-HIRES will impact on fundamental cosmology. In particular we show that a 20 to 30 night program on ELT-HIRES will allow it to play a leading role in fundamental cosmology.

  7. Precision diamond grinding of ceramics and glass

    Energy Technology Data Exchange (ETDEWEB)

    Smith, S.; Paul, H.; Scattergood, R.O.

    1988-12-01

    A new research initiative will be undertaken to investigate the effect of machine parameters and material properties on precision diamond grinding of ceramics and glass. The critical grinding depth to initiate the plastic flow-to-brittle fracture regime will be directly measured using plunge-grind tests. This information will be correlated with machine parameters such as wheel bonding and diamond grain size. Multiaxis grinding tests will then be made to provide data more closely coupled with production technology. One important aspect of the material property studies involves measuring fracture toughness at the very short crack sizes commensurate with grinding damage. Short crack toughness value`s can be much less than the long-crack toughness values measured in conventional fracture tests.

  8. Precise measurement of HFS of positronium

    CERN Document Server

    Ishida, A; Kato, K; Suehara, T; Namba, T; Asai, S; Kobayashi, T; Saito, H; Yoshida, M; Tanaka, K; Yamamoto, A; Ogawa, I; Kobayashi, S; Idehara, T

    2010-01-01

    The ground state hyperfine splitting in positronium, $\\Delta _{\\mathrm{HFS}}$, is sensitive to high order corrections of QED. A new calculation up to $O(\\alpha ^3)$ has revealed a $3.9 \\sigma$ discrepancy between the QED prediction and the experimental results. This discrepancy might either be due to systematic problems in the previous experiments or to contributions beyond the Standard Model. We propose an experiment to measure $\\Delta_{\\mathrm{HFS}}$ employing new methods designed to remedy the systematic errors which may have affected the previous experiments. Our experiment will provide an independent check of the discrepancy. The measurement is in progress and a preliminary result of $\\Delta_{\\mathrm{HFS}} = 203.399 \\pm 0.029 \\mathrm{GHz} (143 \\mathrm{ppm})$ has been obtained. A measurement with a precision of O(1) ppm is expected within a few years.

  9. Precision medicine in patients with allergic diseases

    DEFF Research Database (Denmark)

    Muraro, Antonella; Lemanske, Robert F; Hellings, Peter W

    2016-01-01

    , and design of disease-modifying strategies. Progress has been made in profiling the type 2 immune response-driven asthma. The endotype driven approach for non-type 2 immune response asthma, rhinitis, and atopic dermatitis is lagging behind. Validation and qualification of biomarkers are needed to facilitate......In this consensus document we summarize the current knowledge on major asthma, rhinitis, and atopic dermatitis endotypes under the auspices of the PRACTALL collaboration platform. PRACTALL is an initiative of the European Academy of Allergy and Clinical Immunology and the American Academy...... of Allergy, Asthma & Immunology aiming to harmonize the European and American approaches to best allergy practice and science. Precision medicine is of broad relevance for the management of asthma, rhinitis, and atopic dermatitis in the context of a better selection of treatment responders, risk prediction...

  10. Precision cosmology the first half million years

    CERN Document Server

    Jones, Bernard J T

    2017-01-01

    Cosmology seeks to characterise our Universe in terms of models based on well-understood and tested physics. Today we know our Universe with a precision that once would have been unthinkable. This book develops the entire mathematical, physical and statistical framework within which this has been achieved. It tells the story of how we arrive at our profound conclusions, starting from the early twentieth century and following developments up to the latest data analysis of big astronomical datasets. It provides an enlightening description of the mathematical, physical and statistical basis for understanding and interpreting the results of key space- and ground-based data. Subjects covered include general relativity, cosmological models, the inhomogeneous Universe, physics of the cosmic background radiation, and methods and results of data analysis. Extensive online supplementary notes, exercises, teaching materials, and exercises in Python make this the perfect companion for researchers, teachers and students i...

  11. Precision Cosmology: The First Half Million Years

    Science.gov (United States)

    Jones, Bernard J. T.

    2017-06-01

    Cosmology seeks to characterise our Universe in terms of models based on well-understood and tested physics. Today we know our Universe with a precision that once would have been unthinkable. This book develops the entire mathematical, physical and statistical framework within which this has been achieved. It tells the story of how we arrive at our profound conclusions, starting from the early twentieth century and following developments up to the latest data analysis of big astronomical datasets. It provides an enlightening description of the mathematical, physical and statistical basis for understanding and interpreting the results of key space- and ground-based data. Subjects covered include general relativity, cosmological models, the inhomogeneous Universe, physics of the cosmic background radiation, and methods and results of data analysis. Extensive online supplementary notes, exercises, teaching materials, and exercises in Python make this the perfect companion for researchers, teachers and students in physics, mathematics, and astrophysics.

  12. PRECISE COSMIC RAYS MEASUREMENTS WITH PAMELA

    Directory of Open Access Journals (Sweden)

    A. Bruno

    2013-12-01

    Full Text Available The PAMELA experiment was launched on board the Resurs-DK1 satellite on June 15th 2006. The apparatus was designed to conduct precision studies of charged cosmic radiation over a wide energy range, from tens of MeV up to several hundred GeV, with unprecedented statistics. In five years of continuous data taking in space, PAMELA accurately measured the energy spectra of cosmic ray antiprotons and positrons, as well as protons, electrons and light nuclei, sometimes providing data in unexplored energetic regions. These important results have shed new light in several astrophysical fields like: an indirect search for Dark Matter, a search for cosmological antimatter (anti-Helium, and the validation of acceleration, transport and secondary production models of cosmic rays in the Galaxy. Some of the most important items of Solar and Magnetospheric physics were also investigated. Here we present the most recent results obtained by the PAMELA experiment.

  13. Precision of hand-held dental radiometers.

    Science.gov (United States)

    Rueggeberg, F A

    1993-06-01

    The intensity of light within the wavelengths of 400 to 500 nm on a dental photocurable resin restorative material is a vital factor affecting many of the physical and chemical properties of the resulting restoration. This paper compares the precision of two recently introduced hand-held radiometers. The results indicate that the response of both hand-held meters was linear. For a given amount of decrease in light source intensity, both hand-held units responded with a corresponding decrement in measured intensity value. Both hand-held meters were found to limit their pass band of intensity readings between 400 and 515 nm, making them very useful clinical instruments. However, the absolute intensity readings between the two units were significantly different.

  14. Accelerating scientific computations with mixed precision algorithms

    Science.gov (United States)

    Baboulin, Marc; Buttari, Alfredo; Dongarra, Jack; Kurzak, Jakub; Langou, Julie; Langou, Julien; Luszczek, Piotr; Tomov, Stanimire

    2009-12-01

    On modern architectures, the performance of 32-bit operations is often at least twice as fast as the performance of 64-bit operations. By using a combination of 32-bit and 64-bit floating point arithmetic, the performance of many dense and sparse linear algebra algorithms can be significantly enhanced while maintaining the 64-bit accuracy of the resulting solution. The approach presented here can apply not only to conventional processors but also to other technologies such as Field Programmable Gate Arrays (FPGA), Graphical Processing Units (GPU), and the STI Cell BE processor. Results on modern processor architectures and the STI Cell BE are presented. Program summaryProgram title: ITER-REF Catalogue identifier: AECO_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AECO_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 7211 No. of bytes in distributed program, including test data, etc.: 41 862 Distribution format: tar.gz Programming language: FORTRAN 77 Computer: desktop, server Operating system: Unix/Linux RAM: 512 Mbytes Classification: 4.8 External routines: BLAS (optional) Nature of problem: On modern architectures, the performance of 32-bit operations is often at least twice as fast as the performance of 64-bit operations. By using a combination of 32-bit and 64-bit floating point arithmetic, the performance of many dense and sparse linear algebra algorithms can be significantly enhanced while maintaining the 64-bit accuracy of the resulting solution. Solution method: Mixed precision algorithms stem from the observation that, in many cases, a single precision solution of a problem can be refined to the point where double precision accuracy is achieved. A common approach to the solution of linear systems, either dense or sparse, is to perform the LU

  15. Precise α Determination from τ Decays

    Science.gov (United States)

    Davier, Michel

    2009-04-01

    An updated measurement of α(mτ2) from ALEPH τ hadronic spectral functions is presented. We report a study of the perturbative prediction(s) showing that the fixed-order perturbation theory manifests convergence or principle problems not presented in the contour-improved calculation. Potential systematic effects from quark-hadron duality violations are estimated to be within the quoted systematic errors. The fit result is α(mτ2)=0.344±0.005±0.007, where the first error is experimental and the second theoretical. After evolution, the α(mZ2) determined from τ data is one of the most precise to date, in agreement with the corresponding NLO value derived from Z decays.

  16. Externally Dispersed Interferometry for Precision Radial Velocimetry

    Energy Technology Data Exchange (ETDEWEB)

    Erskine, D J; Muterspaugh, M W; Edelstein, J; Lloyd, J; Herter, T; Feuerstein, W M; Muirhead, P; Wishnow, E

    2007-03-27

    Externally Dispersed Interferometry (EDI) is the series combination of a fixed-delay field-widened Michelson interferometer with a dispersive spectrograph. This combination boosts the spectrograph performance for both Doppler velocimetry and high resolution spectroscopy. The interferometer creates a periodic spectral comb that multiplies against the input spectrum to create moire fringes, which are recorded in combination with the regular spectrum. The moire pattern shifts in phase in response to a Doppler shift. Moire patterns are broader than the underlying spectral features and more easily survive spectrograph blurring and common distortions. Thus, the EDI technique allows lower resolution spectrographs having relaxed optical tolerances (and therefore higher throughput) to return high precision velocity measurements, which otherwise would be imprecise for the spectrograph alone.

  17. Overcoming gaps and bottlenecks to advance precision agriculture

    Science.gov (United States)

    Maintaining a clear understanding of the technology gaps, knowledge needs, and training bottlenecks is required for improving adoption of precision agriculture. As an industry, precision agriculture embraces tools, methods, and practices that are constantly changing, requiring industry, education, a...

  18. WEB CONTENT EXTRACTION USING HYBRID APPROACH

    Directory of Open Access Journals (Sweden)

    K. Nethra

    2014-01-01

    Full Text Available The World Wide Web has rich source of voluminous and heterogeneous information which continues to expand in size and complexity. Many Web pages are unstructured and semi-structured, so it consists of noisy information like advertisement, links, headers, footers etc. This noisy information makes extraction of Web content tedious. Many techniques that were proposed for Web content extraction are based on automatic extraction and hand crafted rule generation. Automatic extraction technique is done through Web page segmentation, but it increases the time complexity. Hand crafted rule generation uses string manipulation function for rule generation, but generating those rules is very difficult. A hybrid approach is proposed to extract main content from Web pages. A HTML Web page is converted to DOM tree and features are extracted and with the extracted features, rules are generated. Decision tree classification and Naïve Bayes classification are machine learning methods used for rules generation. By using the rules, noisy part in the Web page is discarded and informative content in the Web page is extracted. The performance of both decision tree classification and Naïve Bayes classification are measured with metrics like precision, recall, F-measure and accuracy.

  19. Fast Automatic Precision Tree Models from Terrestrial Laser Scanner Data

    Directory of Open Access Journals (Sweden)

    Mathias Disney

    2013-01-01

    Full Text Available This paper presents a new method for constructing quickly and automatically precision tree models from point clouds of the trunk and branches obtained by terrestrial laser scanning. The input of the method is a point cloud of a single tree scanned from multiple positions. The surface of the visible parts of the tree is robustly reconstructed by making a flexible cylinder model of the tree. The thorough quantitative model records also the topological branching structure. In this paper, every major step of the whole model reconstruction process, from the input to the finished model, is presented in detail. The model is constructed by a local approach in which the point cloud is covered with small sets corresponding to connected surface patches in the tree surface. The neighbor-relations and geometrical properties of these cover sets are used to reconstruct the details of the tree and, step by step, the whole tree. The point cloud and the sets are segmented into branches, after which the branches are modeled as collections of cylinders. From the model, the branching structure and size properties, such as volume and branch size distributions, for the whole tree or some of its parts, can be approximated. The approach is validated using both measured and modeled terrestrial laser scanner data from real trees and detailed 3D models. The results show that the method allows an easy extraction of various tree attributes from terrestrial or mobile laser scanning point clouds.

  20. Multi-sensor control for precise assembly of optical components

    Directory of Open Access Journals (Sweden)

    Ma Li

    2014-06-01

    Full Text Available In order to perform an optical assembly accurately, a multi-sensor control strategy is developed which includes an attitude measurement system, a vision system, a loss measurement system and a force sensor. A 3-DOF attitude measuring method using linear variable differential transformers (LVDT is designed to adjust the relation of position and attitude between the spherical mirror and the resonator. A micro vision feedback system is set up to extract the light beam and the diaphragm, which can achieve the coarse positioning of the spherical mirror in the optical assembly process. A rapid self-correlation method is presented to analyze the spectrum signal for the fine positioning. In order to prevent the damage of the optical components and realize sealing of the resonator, a hybrid force-position control is constructed to control the contact force of the optical components. The experimental results show that the proposed multi-sensor control strategy succeeds in accomplishing the precise assembly of the optical components, which consists of parallel adjustment, macro coarse adjustment, macro approach, micro fine adjustment, micro approach and optical contact. Therefore, the results validate the multi-sensor control strategy.

  1. A precise measurement of the top quark mass

    Energy Technology Data Exchange (ETDEWEB)

    Mohr, Brian N. [Univ. of California, Los Angeles, CA (United States)

    2007-04-01

    We present a measurement of the mass of the top quark using data from proton-antiproton collisions recorded at the CDF experiment in Run II of the Fermilab Tevatron. Events are selected from the single lepton plus jets final state (t$\\bar{t}$ → W+bW-$\\bar{b}$ → ℓvbq$\\bar{q}$'$\\bar{b}$). The top quark mass is extracted using a calculation of the probability density for a t$\\bar{t}$ final state to resemble a data event. This probability density is a function of both top quark mass and energy scale of calorimeter jets, constrained in situ with the hadronic W boson mass. Using 167 events observed in 955 pb-1 integrated luminosity, we achieve the single most precise measurement of top quark mass to date of 170.8 ± 2.2 (stat.) ± 1.4 (syst.) GeV/c2, where the quoted statistical uncertainty includes uncertainty from the determination of the jet energy scale.

  2. Calculation of Weighted Geometric Dilution of Precision

    Directory of Open Access Journals (Sweden)

    Chien-Sheng Chen

    2013-01-01

    Full Text Available To achieve high accuracy in wireless positioning systems, both accurate measurements and good geometric relationship between the mobile device and the measurement units are required. Geometric dilution of precision (GDOP is widely used as a criterion for selecting measurement units, since it represents the geometric effect on the relationship between measurement error and positioning determination error. In the calculation of GDOP value, the maximum volume method does not necessarily guarantee the selection of the optimal four measurement units with minimum GDOP. The conventional matrix inversion method for GDOP calculation demands a large amount of operation and causes high power consumption. To select the subset of the most appropriate location measurement units which give the minimum positioning error, we need to consider not only the GDOP effect but also the error statistics property. In this paper, we employ the weighted GDOP (WGDOP, instead of GDOP, to select measurement units so as to improve the accuracy of location. The handheld global positioning system (GPS devices and mobile phones with GPS chips can merely provide limited calculation ability and power capacity. Therefore, it is very imperative to obtain WGDOP accurately and efficiently. This paper proposed two formations of WGDOP with less computation when four measurements are available for location purposes. The proposed formulae can reduce the computational complexity required for computing the matrix inversion. The simpler WGDOP formulae for both the 2D and the 3D location estimation, without inverting a matrix, can be applied not only to GPS but also to wireless sensor networks (WSN and cellular communication systems. Furthermore, the proposed formulae are able to provide precise solution of WGDOP calculation without incurring any approximation error.

  3. Precise Masses in the WASP-47 System

    Science.gov (United States)

    Vanderburg, Andrew; Becker, Juliette C.; Buchhave, Lars A.; Mortier, Annelies; Lopez, Eric; Malavolta, Luca; Haywood, Raphaëlle D.; Latham, David W.; Charbonneau, David; López-Morales, Mercedes; Adams, Fred C.; Bonomo, Aldo Stefano; Bouchy, François; Collier Cameron, Andrew; Cosentino, Rosario; Di Fabrizio, Luca; Dumusque, Xavier; Fiorenzano, Aldo; Harutyunyan, Avet; Johnson, John Asher; Lorenzi, Vania; Lovis, Christophe; Mayor, Michel; Micela, Giusi; Molinari, Emilio; Pedani, Marco; Pepe, Francesco; Piotto, Giampaolo; Phillips, David; Rice, Ken; Sasselov, Dimitar; Ségransan, Damien; Sozzetti, Alessandro; Udry, Stéphane; Watson, Chris

    2017-12-01

    We present precise radial velocity observations of WASP-47, a star known to host a hot Jupiter, a distant Jovian companion, and, uniquely, two additional transiting planets in short-period orbits: a super-Earth in a ≈19 hr orbit, and a Neptune in a ≈9 day orbit. We analyze our observations from the HARPS-N spectrograph along with previously published data to measure the most precise planet masses yet for this system. When combined with new stellar parameters and reanalyzed transit photometry, our mass measurements place strong constraints on the compositions of the two small planets. We find that, unlike most other ultra-short-period planets, the inner planet, WASP-47 e, has a mass (6.83 ± 0.66 {M}\\oplus ) and a radius (1.810 ± 0.027 {R}\\oplus ) that are inconsistent with an Earth-like composition. Instead, WASP-47 e likely has a volatile-rich envelope surrounding an Earth-like core and mantle. We also perform a dynamical analysis to constrain the orbital inclination of WASP-47 c, the outer Jovian planet. This planet likely orbits close to the plane of the inner three planets, suggesting a quiet dynamical history for the system. Our dynamical constraints also imply that WASP-47 c is much more likely to transit than a geometric calculation would suggest. We calculate a transit probability for WASP-47 c of about 10%, more than an order of magnitude larger than the geometric transit probability of 0.6%.

  4. Apparatus for hydrocarbon extraction

    Science.gov (United States)

    Bohnert, George W.; Verhulst, Galen G.

    2013-03-19

    Systems and methods for hydrocarbon extraction from hydrocarbon-containing material. Such systems and methods relate to extracting hydrocarbon from hydrocarbon-containing material employing a non-aqueous extractant. Additionally, such systems and methods relate to recovering and reusing non-aqueous extractant employed for extracting hydrocarbon from hydrocarbon-containing material.

  5. Measurement of the Positive Muon Lifetime and Determination of the Fermi Constant to Part-per-Million Precision

    CERN Document Server

    Webber, D M; ~Peng, Q; Battu, S; Carey, R M; Chitwood, D B; Crnkovic, J; Debevec, P T; Dhamija, S; Earle, W; Gafarov, A; Giovanetti, K; Gorringe, T P; Gray, F E; Hartwig, Z; Hertzog, D W; Johnson, B; Kammel, P; Kiburg, B; Kizilgul, S; Kunkle, J; Lauss, B; Logashenko, I; Lynch, K R; McNabb, R; Miller, J P; Mulhauser, F; Onderwater, C J G; Phillips, J; Rath, S; Roberts, B L; Winter, P; Wolfe, B

    2010-01-01

    We report a measurement of the positive muon lifetime to a precision of 1.0~parts per million (ppm); it is the most precise particle lifetime ever measured. The experiment used a time-structured, low-energy muon beam and a segmented plastic scintillator array to record more than 2 x 10^{12} decays. Two different stopping target configurations were employed in independent data-taking periods. The combined results give tau_{mu^+}(MuLan) = 2196980.3(2.2)~ps, more than 15 times as precise as any previous experiment. The muon lifetime gives the most precise value for the Fermi constant: G_F(MuLan) = 1.1663788 (7) x 10^-5 GeV^-2 (0.6~ppm). It is also used to extract the mu^-p singlet capture rate, which determines the proton's weak induced pseudoscalar coupling g_P.

  6. The Moral and Ethical Implications of Precision-Guided Munitions

    Science.gov (United States)

    2007-03-01

    less than precise. “Its achievements,” according to Stephen McFarland, “remain the stuff of mythology .”43 “Precision bomb- ing” proved to be a very... Easter offensive in April and May 192 were the result of aerial-precision attacks.6 The efficiency of PGMs did not escape the attention of airpower

  7. Figure text extraction in biomedical literature.

    Directory of Open Access Journals (Sweden)

    Daehyun Kim

    Full Text Available BACKGROUND: Figures are ubiquitous in biomedical full-text articles, and they represent important biomedical knowledge. However, the sheer volume of biomedical publications has made it necessary to develop computational approaches for accessing figures. Therefore, we are developing the Biomedical Figure Search engine (http://figuresearch.askHERMES.org to allow bioscientists to access figures efficiently. Since text frequently appears in figures, automatically extracting such text may assist the task of mining information from figures. Little research, however, has been conducted exploring text extraction from biomedical figures. METHODOLOGY: We first evaluated an off-the-shelf Optical Character Recognition (OCR tool on its ability to extract text from figures appearing in biomedical full-text articles. We then developed a Figure Text Extraction Tool (FigTExT to improve the performance of the OCR tool for figure text extraction through the use of three innovative components: image preprocessing, character recognition, and text correction. We first developed image preprocessing to enhance image quality and to improve text localization. Then we adapted the off-the-shelf OCR tool on the improved text localization for character recognition. Finally, we developed and evaluated a novel text correction framework by taking advantage of figure-specific lexicons. RESULTS/CONCLUSIONS: The evaluation on 382 figures (9,643 figure texts in total randomly selected from PubMed Central full-text articles shows that FigTExT performed with 84% precision, 98% recall, and 90% F1-score for text localization and with 62.5% precision, 51.0% recall and 56.2% F1-score for figure text extraction. When limiting figure texts to those judged by domain experts to be important content, FigTExT performed with 87.3% precision, 68.8% recall, and 77% F1-score. FigTExT significantly improved the performance of the off-the-shelf OCR tool we used, which on its own performed with 36

  8. Study of the use of personal equipment in low coal. Experiments on personal equipment for low seam coal miners: VI. Comparison bumping hazards with high and low profile helmets. Phase II report, number 6. Open file report 1 Jan 79-1 Sep 79

    Energy Technology Data Exchange (ETDEWEB)

    Sanders, M.; Wick, D.; Krohn, G.

    1980-01-31

    The objective of this study was to determine optimal personal equipment design for use in low coal based on ergonomic, biomechanic, and safety considerations. This report describes an experiment that was conducted to compare the relative bumping hazards of a low- and high-profile hard hat (helmet) in a low seam mining environment. The study was specifically designed to assess the effect of lowering the helmet profile on frequency of head impacts.

  9. Beam loss caused by edge focusing of injection bump magnets and its mitigation in the 3-GeV rapid cycling synchrotron of the Japan Proton Accelerator Research Complex

    Directory of Open Access Journals (Sweden)

    H. Hotchi

    2016-01-01

    Full Text Available In the 3-GeV rapid cycling synchrotron of the Japan Proton Accelerator Research Complex, transverse injection painting is utilized not only to suppress space-charge induced beam loss in the low energy region but also to mitigate foil scattering beam loss during charge-exchange injection. The space-charge induced beam loss is well minimized by the combination of modest transverse painting and full longitudinal painting. But, for sufficiently mitigating the foil scattering part of beam loss, the transverse painting area has to be further expanded. However, such a wide-ranging transverse painting had not been realized until recently due to beta function beating caused by edge focusing of pulsed injection bump magnets during injection. This beta function beating additionally excites random betatron resonances through a distortion of the lattice superperiodicity, and its resultant deterioration of the betatron motion stability causes significant extra beam loss when expanding the transverse painting area. To solve this issue, we newly installed pulse-type quadrupole correctors to compensate the beta function beating. This paper presents recent experimental results on this correction scheme for suppressing the extra beam loss, while discussing the beam loss and its mitigation mechanisms with the corresponding numerical simulations.

  10. Precise nuclear physics for the sun

    Energy Technology Data Exchange (ETDEWEB)

    Bemmerer, Daniel

    2012-07-01

    For many centuries, the study of the Sun has been an important testbed for understanding stars that are further away. One of the first astronomical observations Galileo Galilei made in 1612 with the newly invented telescope concerned the sunspots, and in 1814, Joseph von Fraunhofer employed his new spectroscope to discover the absorption lines in the solar spectrum that are now named after him. Even though more refined and new modes of observation are now available than in the days of Galileo and Fraunhofer, the study of the Sun is still high on the agenda of contemporary science, due to three guiding interests. The first is connected to the ages-old human striving to understand the structure of the larger world surrounding us. Modern telescopes, some of them even based outside the Earth's atmosphere in space, have succeeded in observing astronomical objects that are billions of light-years away. However, for practical reasons precision data that are important for understanding stars can still only be gained from the Sun. In a sense, the observations of far-away astronomical objects thus call for a more precise study of the closeby, of the Sun, for their interpretation. The second interest stems from the human desire to understand the essence of the world, in particular the elementary particles of which it consists. Large accelerators have been constructed to produce and collide these particles. However, man-made machines can never be as luminous as the Sun when it comes to producing particles. Solar neutrinos have thus served not only as an astronomical tool to understand the Sun's inner workings, but their behavior on the way from the Sun to the Earth is also being studied with the aim to understand their nature and interactions. The third interest is strictly connected to life on Earth. A multitude of research has shown that even relatively slight changes in the Earth's climate may strongly affect the living conditions in a number of densely

  11. Precision Departure Release Capability (PDRC) Technology Description

    Science.gov (United States)

    Engelland, Shawn A.; Capps, Richard; Day, Kevin; Robinson, Corissia; Null, Jody R.

    2013-01-01

    After takeoff, aircraft must merge into en route (Center) airspace traffic flows which may be subject to constraints that create localized demand-capacity imbalances. When demand exceeds capacity, Traffic Management Coordinators (TMCs) often use tactical departure scheduling to manage the flow of departures into the constrained Center traffic flow. Tactical departure scheduling usually involves use of a Call for Release (CFR) procedure wherein the Tower must call the Center TMC to coordinate a release time prior to allowing the flight to depart. In present-day operations release times are computed by the Center Traffic Management Advisor (TMA) decision support tool based upon manual estimates of aircraft ready time verbally communicated from the Tower to the Center. The TMA-computed release is verbally communicated from the Center back to the Tower where it is relayed to the Local controller as a release window that is typically three minutes wide. The Local controller will manage the departure to meet the coordinated release time window. Manual ready time prediction and verbal release time coordination are labor intensive and prone to inaccuracy. Also, use of release time windows adds uncertainty to the tactical departure process. Analysis of more than one million flights from January 2011 indicates that a significant number of tactically scheduled aircraft missed their en route slot due to ready time prediction uncertainty. Uncertainty in ready time estimates may result in missed opportunities to merge into constrained en route flows and lead to lost throughput. Next Generation Air Transportation System (NextGen) plans call for development of Tower automation systems capable of computing surface trajectory-based ready time estimates. NASA has developed the Precision Departure Release Capability (PDRC) concept that uses this technology to improve tactical departure scheduling by automatically communicating surface trajectory-based ready time predictions to the

  12. Precision Departure Release Capability (PDRC) Final Report

    Science.gov (United States)

    Engelland, Shawn A.; Capps, Richard; Day, Kevin Brian; Kistler, Matthew Stephen; Gaither, Frank; Juro, Greg

    2013-01-01

    After takeoff, aircraft must merge into en route (Center) airspace traffic flows that may be subject to constraints that create localized demand/capacity imbalances. When demand exceeds capacity, Traffic Management Coordinators (TMCs) and Frontline Managers (FLMs) often use tactical departure scheduling to manage the flow of departures into the constrained Center traffic flow. Tactical departure scheduling usually involves a Call for Release (CFR) procedure wherein the Tower must call the Center to coordinate a release time prior to allowing the flight to depart. In present-day operations release times are computed by the Center Traffic Management Advisor (TMA) decision support tool, based upon manual estimates of aircraft ready time verbally communicated from the Tower to the Center. The TMA-computed release time is verbally communicated from the Center back to the Tower where it is relayed to the Local controller as a release window that is typically three minutes wide. The Local controller will manage the departure to meet the coordinated release time window. Manual ready time prediction and verbal release time coordination are labor intensive and prone to inaccuracy. Also, use of release time windows adds uncertainty to the tactical departure process. Analysis of more than one million flights from January 2011 indicates that a significant number of tactically scheduled aircraft missed their en route slot due to ready time prediction uncertainty. Uncertainty in ready time estimates may result in missed opportunities to merge into constrained en route flows and lead to lost throughput. Next Generation Air Transportation System plans call for development of Tower automation systems capable of computing surface trajectory-based ready time estimates. NASA has developed the Precision Departure Release Capability (PDRC) concept that improves tactical departure scheduling by automatically communicating surface trajectory-based ready time predictions and departure

  13. Precision and Accuracy in PDV and VISAR

    Energy Technology Data Exchange (ETDEWEB)

    Ambrose, W. P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-08-22

    This is a technical report discussing our current level of understanding of a wide and varying distribution of uncertainties in velocity results from Photonic Doppler Velocimetry in its application to gas gun experiments. Using propagation of errors methods with statistical averaging of photon number fluctuation in the detected photocurrent and subsequent addition of electronic recording noise, we learn that the velocity uncertainty in VISAR can be written in closed form. For PDV, the non-linear frequency transform and peak fitting methods employed make propagation of errors estimates notoriously more difficult to write down in closed form expect in the limit of constant velocity and low time resolution (large analysis-window width). An alternative method of error propagation in PDV is to use Monte Carlo methods with a simulation of the time domain signal based on results from the spectral domain. A key problem for Monte Carlo estimation for an experiment is a correct estimate of that portion of the time-domain noise associated with the peak-fitting region-of-interesting in the spectral domain. Using short-time Fourier transformation spectral analysis and working with the phase dependent real and imaginary parts allows removal of amplitude-noise cross terms that invariably show up when working with correlation-based methods or FFT power spectra. Estimation of the noise associated with a given spectral region of interest is then possible. At this level of progress, we learn that Monte Carlo trials with random recording noise and initial (uncontrolled) phase yields velocity uncertainties that are not as large as those observed. In a search for additional noise sources, a speckleinterference modulation contribution with off axis rays was investigated, and was found to add a velocity variation beyond that from the recording noise (due to random interference between off axis rays), but in our experiments the speckle modulation precision was not as important as the

  14. Accurate and Automatic Building Roof Extraction Using Neighborhood Information of Point Clouds

    Directory of Open Access Journals (Sweden)

    ZHAO Chuan

    2017-09-01

    Full Text Available High accuracy building roof extraction from LiDAR data is the key to build topological relationship of building roofs and reconstruct buildings. Aiming at the poor adaptation and low extraction precision of existing roof extraction methods for complex building, an accurate and automatic building roof extraction method using neighborhood information of point clouds is proposed. Point clouds features are calculated by principle component analysis, and reliable seed points are selected after feature histogram construction. Initial roof surfaces are extracted quickly and precisely by the proposed local normal vector distribution density-based spatial clustering of applications with noise (LNVD-DBSCAN. Roof competition problem is solved effectively by the poll model based on neighborhood information. Experimental results show that the proposed method can extract building roofs automatically and precisely, and has preferable adaptation to buildings with different complexity, which is able to provide reliable roof information for building reconstruction.

  15. Precision electroweak measurements on the $Z$ resonance

    CERN Document Server

    Schael, S; Brunelière, R; Buskulic, Damir; De Bonis, I; Décamp, D; Ghez, P; Goy, C; Jézéquel, S; Lees, J P; Lucotte, A; Martin, F; Merle, E; Minard, M N; Nief, J Y; Odier, P; Pietrzyk, B; Trocmé, B; Bravo, S; Casado, M P; Chmeissani, M; Comas, P; Crespo, J M; Fernández, E; Fernández-Bosman, M; Garrido, L; Graugès-Pous, E; Juste, A; Martínez, M; Merino, G; Miquel, R; Mir, L M; Orteu, S; Pacheco, A; Park, I C; Perlas, J; Riu, I; Ruiz, H; Sánchez, F; Colaleo, A; Creanza, D; De Filippis, N; De Palma, M; Iaselli, G; Maggi, G; Maggi, M; Nuzzo, S; Ranieri, A; Raso, G; Ruggieri, F; Selvaggi, G; Silvestris, L; Tempesta, P; Tricomi, A; Zito, G; Huang, X; Lin, J; Ouyang, Q; Wang, T; Xie, Y; Xu, R; Xue, S; Zhang, J; Zhang, L; Zhao, W; Abbaneo, D; Bazarko, A; Becker, U; Boix, G; Bird, F; Blucher, E; Bonvicini, B; Bright-Thomas, P; Barklow, T; Cattaneo, M; Cerutti, F; Clerbaux, B; Drevermann, H; Forty, R W; Frank, M; Greening, T C; Hagelberg, R; Halley, A W; Gianotti, F; Girone, M; Hansen, J B; Harvey, J; Jacobsen, R; Hutchcroft, D E; Janot, P; Jost, B; Knobloch, J; Kado, M; Lehraus, Ivan; Lazeyras, Pierre; Maley, P; Mato, P; May, J; Moutoussi, A; Pepé-Altarelli, M; Ranjard, F; Rolandi, Luigi; Schlatter, W D; Schmitt, B; Schneider, O; Tejessy, W; Teubert, F; Tomalin, I R; Tournefier, E; Veenhof, R; Valassi, A; Wiedenmann, W; Wright, A E; Ajaltouni, Ziad J; Badaud, F; Chazelle, G; Deschamps, O; Dessagne, S; Falvard, A; Ferdi, C; Fayolle, D; Gay, P; Guicheney, C; Henrard, P; Jousset, J; Michel, B; Monteil, S; Montret, J C; Pallin, D; Pascolo, J M; Perret, P; Podlyski, F; Bertelsen, H; Fernley, T; Hansen, J D; Hansen, J R; Hansen, P H; Kraan, A C; Lindahl, A; Møllerud, R; Nilsson, B S; Rensch, B; Wäänänen, A; Daskalakis, G; Kyriakis, A; Markou, C; Simopoulou, E; Siotis, I; Vayaki, A; Blondel, A; Bonneaud, G; Brient, J C; Machefert, F; Rougé, A; Rumpf, M; Swynghedauw, M; Tanaka, R; Verderi, M; Videau, H L; Ciulli, V; Focardi, E; Parrini, G; Zachariadou, K; Corden, M; Georgiopoulos, C H; Antonelli, A; Antonelli, M; Bencivenni, G; Bologna, G; Bossi, F; Campana, P; Capon, G; Chiarella, V; Felici, G; Laurelli, P; Mannocchi, G; Murtas, G P; Passalacqua, L; Picchi, P; Colrain, P; ten Have, I; Hughes, I S; Kennedy, J; Knowles, I G; Lynch, J G; Morton, W T; Negus, P; O'Shea, V; Raine, C; Reeves, P; Scarr, J M; Smith, K; Thompson, A S; Turnbull, R M; Wasserbaech, S R; Buchmüller, O L; Cavanaugh, R J; Dhamotharan, S; Geweniger, C; Hanke, P; Hansper, G; Hepp, V; Kluge, E E; Putzer, A; Sommer, J; Tittel, K; Werner, W; Wunsch, M; Beuselinck, R; Binnie, D M; Cameron, W; Davies, G; Dornan, P J; Goodsir, S M; Marinelli, N; Martin, E; Nash, J; Nowell, J; Rutherford, S A; Sedgbeer, J K; Thompson, J C; White, R; Williams, M D; Ghete, V M; Girtler, P; Kneringer, E; Kuhn, D; Rudolph, G; Bouhova-Thacker, E; Bowdery, C K; Buck, P G; Clarke, D P; Ellis, G; Finch, A J; Foster, F; Hughes, G; Jones, R W L; Keemer, N R; Pearson, M R; Robertson, N A; Sloan, T; Smizanska, M; Snow, S W; Williams, M I; van der Aa, O; Delaere, C; Leibenguth, G; Lemaître, V; Bauerdick, L A T; Blumenschein, U; Van Gemmeren, P; Giehl, I; Hölldorfer, F; Jakobs, K; Kasemann, M; Kayser, F; Kleinknecht, K; Müller, A S; Quast, G; Renk, B; Rohne, E; Sander, H G; Schmeling, S; Wachsmuth, H W; Wanke, R; Zeitnitz, C; Ziegler, T; Aubert, Jean-Jacques; Benchouk, C; Bonissent, A; Carr, J; Coyle, P; Curtil, C; Ealet, A; Etienne, F; Fouchez, D; Motsch, F; Payre, P; Rousseau, D; Talby, M; Thulasidas, M; Aleppo, M; Ragusa, F; Büscher, V; David, A; Dietl, H; Ganis, G; Hüttmann, K; Lütjens, G; Mannert, C; Männer, W; Moser, H G; Settles, R; Seywerd, H; Stenzel, H; Villegas, M; Wolf, G; Boucrot, J; Callot, O; Chen, S; Cordier, A; Davier, M; Duflot, L; Grivaz, J F; Heusse, P; Jacholkowska, A; Le Diberder, F R; Lefrançois, J; Mutz, A M; Schune, M H; Serin, L; Veillet, J J; Videau, I; Zerwas, D; Azzurri, P; Bagliesi, G; Bettarini, S; Boccali, T; Bozzi, C; Calderini, G; Dell'Orso, R; Fantechi, R; Ferrante, I; Fidecaro, F; Foà, L; Giammanco, A; Giassi, A; Gregorio, A; Ligabue, F; Lusiani, A; Marrocchesi, P S; Messineo, A; Palla, F; Rizzo, G; Sanguinetti, G; Sciabà, A; Sguazzoni, G; Spagnolo, P; Steinberger, J; Tenchini, R; Vannini, C; Venturi, A; Verdini, P G; Awunor, O; Blair, G A; Cowan, G; García-Bellido, A; Green, M G; Medcalf, T; Strong, J A; Teixeira-Dias, P; Botterill, David R; Clifft, R W; Edgecock, T R; Edwards, M; Haywood, S J; Norton, P R; Ward, J J; Bloch-Devaux, B; Boumediene, D E; Colas, P; Emery, S; Fabbro, B; Kozanecki, Witold; Lançon, E; Lemaire, M C; Locci, E; Pérez, P; Rander, J; Renardy, J F; Roussarie, A; Schuller, J P; Schwindling, J; Tuchming, B; Vallage, B; Black, S N; Dann, J H; Kim, H Y; Konstantinidis, N P; Litke, A M; McNeil, M A; Taylor, G; Booth, C N; Cartwright, S; Combley, F; Hodgson, P N; Lehto, M H; Thompson, L F; Affholderbach, K; Barberio, E; Böhrer, A; Brandt, S; Burkhardt, H; Feigl, E; Grupen, C; Hess, J; Lutters, G; Meinhard, H; Minguet-Rodríguez, J A; Mirabito, L; Misiejuk, A; Neugebauer, E; Ngac, A; Prange, G; Rivera, F; Saraiva, P; Schäfer, U; Sieler, U; Smolik, L; Stephan, F; Trier, H; Apollonio, M; Borean, C; Bosisio, L; Della Marina, R; Giannini, G; Gobbo, B; Musolino, G; Pitis, L; He, H; Kim, H; Pütz, J; Rothberg, J E; Armstrong, S R; Bellantoni, L; Berkelman, K; Cinabro, D; Conway, J S; Cranmer, K; Elmer, P; Feng, Z; Ferguson, D P S; Gao, Y; González, S; Grahl, J; Harton, J L; Hayes, O J; Hu, H; Jin, S; Johnson, R P; Kile, J; McNamara, P A; Nielsen, J; Orejudos, W; Pan, Y B; Saadi, Y; Scott, I J; Sharma, V; Walsh, A M; Walsh, J; Wear, J; Von Wimmersperg-Töller, J H; Wu, J; Wu, S L; Wu, X; Yamartino, J M; Zobernig, G; Dissertori, G; Abdallah, J; Abreu, P; Adam, W; Adye, T; Adzic, P; Ajinenko, I; Albrecht, T; Alderweireld, T; Alekseev, G D; Alemany-Fernandez, R; Allmendinger, T; Allport, P P; Almehed, S; Amaldi, Ugo; Amapane, N; Amato, S; Anashkin, E; Anassontzis, E G; Andersson, P; Andreazza, A; Andringa, S; Anjos, N; Antilogus, P; Apel, W D; Arnoud, Y; Ask, S; Åsman, B; Augustin, J E; Augustinus, A; Baillon, Paul; Ballestrero, A; Bambade, P; Barão, F; Barbiellini, G; Barbier, R; Bardin, D; Barker, G; Baroncelli, A; Battaglia, M; Baubillier, M; Becks, K H; Begalli, M; Behrmann, A; Beillière, P; Belokopytov, Yu A; Belous, K S; Ben-Haim, E; Benekos, N; Benvenuti, A C; Bérat, C; Berggren, M; Berntzon, L; Bertini, D; Bertrand, D; Besançon, M; Besson, N; Bianchi, F; Bigi, M; Bilenky, S M; Bizouard, M A; Bloch, D; Blom, M; Bluj, M; Bonesini, M; Bonivento, W; Boonekamp, M; Booth, P S L; Borgland, A W; Borisov, G; Bosio, C; Botner, O; Boudinov, E; Bouquet, B; Bourdarios, C; Bowcock, T J V; Boyko, I; Bozovic, I; Bozzo, M; Bracko, M; Branchini, P; Brenke, T; Brenner, R; Brodet, E; Brückman, P; Brunet, J M; Bugge, L; Buran, T; Burgsmüller, T; Buschbeck, Brigitte; Buschmann, P; Cabrera, S; Caccia, M; Calvi, M; Camacho-Rozas, A J; Camporesi, T; Canale, V; Canepa, M; Carena, F; Carroll, L; Caso, C; Castillo-Gimenez, M V; Castro, N; Cattai, A; Cavallo, F; Chabaud, V; Chapkin, M; Charpentier, P; Chaussard, L; Checchia, P; Chelkov, G A; Chen, M; Chierici, R; Shlyapnikov, P; Chochula, P; Chorowicz, V; Chudoba, J; Chung, S U; Cieslik, K; Collins, P; Colomer, M; Contri, R; Cortina, E; Cosme, G; Cossutti, F; Costa, M J; Cowell, J H; Crawley, H B; Crennell, D J; Crépé, S; Crosetti, G; Cuevas-Maestro, J; Czellar, S; D'Hondt, J; D'Almagne, B; Dalmau, J; Damgaard, G; Davenport, M; Da Silva, T; Da Silva, W; Deghorain, A; Della Ricca, G; Delpierre, P A; Demaria, N; De Angelis, A; de Boer, Wim; De Brabandere, S; De Clercq, C; De Lotto, B; De Maria, N; De Min, A; De Paula, L; Dijkstra, H; Di Ciaccio, L; Di Diodato, A; Di Simone, A; Djannati, A; Dolbeau, J; Doroba, K; Dracos, M; Drees, J; Drees, K A; Dris, M; Duperrin, A; Durand, J D; Ehret, R; Eigen, G; Ekelöf, T J C; Ekspong, G; Ellert, M; Elsing, M; Engel, J P; Erzen, B; Espirito-Santo, M C; Falk, E; Fanourakis, G K; Fassouliotis, D; Fayot, J; Feindt, M; Fenyuk, A; Fernández, J; Ferrari, P; Ferrer, A; Ferrer-Ribas, E; Ferro, F; Fichet, S; Firestone, A; Fischer, P A; Flagmeyer, U; Föth, H; Fokitis, E; Fontanelli, F; Franek, B; Frodesen, A G; Frühwirth, R; Fulda-Quenzer, F; Fuster, J; Galloni, A; Gamba, D; Gamblin, S; Gandelman, M; García, C; García, J; Gaspar, C; Gaspar, M; Gasparini, U; Gavillet, P; Gazis, E; Gelé, D; Gerber, J P; Gerdyukov, L N; Ghodbane, N; Gil, I; Glege, F; Gokieli, R; Golob, B; Gómez-Ceballos, G; Gonçalves, P; González-Caballero, I; Gopal, G; Gorn, L; Górski, M; Guz, Yu; Gracco, Valerio; Graziani, E; Green, C; Grefrath, A; Grimm, H J; Gris, P; Grosdidier, G; Grzelak, K; Günther, M; Guy, J; Haag, C; Hahn, F; Hahn, S; Haider, S; Hallgren, A; Hamacher, K; Hamilton, K; Hansen, J; Harris, F J; Haug, S; Hauler, F; Hedberg, V; Heising, S; Hennecke, M; Henriques, R; Hernández, J J; Herquet, P; Herr, H; Hessing, T L; Heuser, J M; Higón, E; Hoffman, J; Holmgren, S O; Holt, P J; Holthuizen, D J; Hoorelbeke, S; Houlden, M A; Hrubec, Josef; Huber, M; Huet, K; Hughes, G J; Hultqvist, K; Jackson, J N; Jacobsson, R; Jalocha, P; Janik, R; Jarlskog, C; Jarlskog, G; Jarry, P; Jean-Marie, B; Jeans, D; Johansson, E K; Johansson, P D; Jonsson, P; Joram, C; Juillot, P; Jungermann, L; Kapusta, F; Karafasoulis, K; Katsanevas, S; Katsoufis, E C; Keränen, R; Kernel, G; Kersevan, B P; Kerzel, U; Khomenko, B A; Khovanskii, N N; Kiiskinen, A P; King, B T; Kinvig, A; Kjaer, N J; Klapp, O; Klein, H; Kluit, P; Knoblauch, D; Kokkinias, P; Konoplyannikov, A K; Koratzinos, M; Kostyukhin, V; Kourkoumelis, C; Kuznetsov, O; Krammer, M; Kreuter, C; Kriznic, E; Krstic, J; Krumshtein, Z; Kubinec, P; Kucewicz, W; Kucharczyk, M; Kurowska, J; Kurvinen, K; Lamsa, J; Lanceri, L; Lane, D W; Langefeld, P; Lapin, V; Laugier, J P; Lauhakangas, R; Leder, G; Ledroit, F; Lefébure, V; Leinonen, L; Leisos, A; Leitner, R; Lemonne, J; Lenzen, G; Lepeltier, V; Lesiak, T; Lethuillier, M; Libby, J; Liebig, W; Liko, D; Lipniacka, A; Lippi, I; Lörstad, B; Lokajícek, M; Loken, J G; Lopes, J H; López, J M; López-Fernandez, R; Loukas, D; Lutz, P; Lyons, L; MacNaughton, J; Mahon, J R; Maio, A; Malek, A; Malmgren, T G M; Maltezos, S; Malychev, V; Mandl, F; Marco, J; Marco, R; Maréchal, B; Margoni, M; Marin, J C; Mariotti, C; Markou, A; Martínez-Rivero, C; Martínez-Vidal, F; Martí i García, S; Masik, J; Mastroyiannopoulos, N; Matorras, F; Matteuzzi, C; Matthiae, Giorgio; Mazzucato, F; Mazzucato, M; McCubbin, M; McKay, R; McNulty, R; McPherson, G; Meroni, C; Meyer, W T; Myagkov, A; Migliore, E; Mitaroff, W A; Mjörnmark, U; Moa, T; Moch, M; Møller, R; Mönig, K; Monge, R; Montenegro, J; Moraes, D; Moreau, X; Moreno, S; Morettini, P; Morton, G; Müller, U; Münich, K; Mulders, M; Mulet-Marquis, C; Mundim, L; Muresan, R; Murray, W; Muryn, B; Myatt, G; Myklebust, T; Naraghi, F; Nassiakou, M; Navarria, Francesco Luigi; Navas, S; Nawrocki, K; Negri, P; Neufeld, N; Neumann, W; Neumeister, N; Nicolaidou, R; Nielsen, B S; Nieuwenhuizen, M; Niezurawski, P; Nikolaenko, V; Nikolenko, M; Nomokonov, V P; Normand, A; Nygren, A; Oblakowska-Mucha, A; Obraztsov, V F; Olshevskii, A G; Onofre, A; Orava, R; Orazi, G; Österberg, K; Ouraou, A; Oyanguren, A; Paganini, P; Paganoni, M; Paiano, S; Pain, R; Paiva, R; Palacios, J P; Palka, H; Papadopoulou, T D; Papageorgiou, K; Pape, L; Parkes, C; Parodi, F; Parzefall, U; Passeri, A; Passon, O; Pavel, T; Pegoraro, M; Peralta, L; Perepelitsa, V F; Pernicka, M; Perrotta, A; Petridou, C; Petrolini, A; Phillips, H T; Piana, G; Piedra, J; Pieri, L; Pierre, F; Pimenta, M; Piotto, E; Podobnik, T; Poireau, V; Pol, M E; Polok, G; Polycarpo, E; Poropat, P; Pozdnyakov, V; Privitera, P; Pukhaeva, N; Pullia, A; Radojicic, D; Ragazzi, S; Rahmani, H; Rakoczy, D; Rames, J; Ramler, L; Ratoff, P N; Read, A; Rebecchi, P; Redaelli, N G; Regler, Meinhard; Rehn, J; Reid, D; Reinhardt, R; Renton, P B; Resvanis, L K; Richard, F; Rídky, J; Rinaudo, G; Ripp-Baudot, I; Rivero, M; Rodríguez, D; Rohne, O; Romero, A; Ronchese, P; Rosenberg, E I; Rosinsky, P; Roudeau, P; Rovelli, T; Royon, C; Ruhlmann-Kleider, V; Ruiz, A; Ryabtchikov, D; Saarikko, H; Sacquin, Yu; Sadovskii, A; Sajot, G; Salmi, L; Salt, J; Sampsonidis, D; Sannino, M; Savoy-Navarro, A; Scheidle, T; Schneider, H; Schwemling, P; Schwering, B; Schwickerath, U; Schyns, M A E; Scuri, F; Seager, P; Sedykh, Yu; Segar, A; Seibert, N; Sekulin, R L; Shellard, R C; Sheridan, A; Siebel, M; Silvestre, R; Simard, L; Simonetto, F; Sisakian, A; Skaali, T B; Smadja, G; Smirnov, N; Smirnova, O; Smith, G R; Sokolov, A; Sopczak, A; Sosnowski, R; Spassoff, Tz; Spiriti, E; Sponholz, P; Squarcia, S; Stampfer, D; Stanescu, C; Stanic, S; Stanitzki, M; Stapnes, S; Stevenson, K; Stocchi, A; Strauss, J; Strub, R; Stugu, B; Szczekowski, M; Szeptycka, M; Szumlak, T; Tabarelli de Fatis, T; Taffard, A C; Tegenfeldt, F; Terranova, F; Thomas, J; Tilquin, A; Timmermans, J; Tinti, N; Tkatchev, L G; Tobin, M; Todorov, T; Todorovova, S; Toet, D Z; Tomaradze, A G; Tomé, B; Tonazzo, A; Tortora, L; Tortosa, P; Tranströmer, G; Travnicek, P; Treille, D; Tristram, G; Trochimczuk, M; Trombini, A; Troncon, C; Tsirou, A; Turluer, M L; Tyapkin, I A; Tyapkin, P; Tzamarias, S; Ullaland, O; Uvarov, V; Valenti, G; Vallazza, E; Van der Velde, C; van Apeldoorn, G W; van Dam, P; Van den Boeck, W; Van Doninck, W K; Van Eldik, J; Van Lysebetten, A; Van Remortel, N; Van Vulpen, I; Vassilopoulos, N; Vegni, G; Veloso, F; Ventura, L; Venus, W; Verbeure, F; Verdier, P; Verlato, M; Vertogradov, L S; Verzi, V; Vilanova, D; Vitale, L; Vlasov, E; Vodopyanov, A S; Vollmer, C; Voulgaris, G; Vrba, V; Wahlen, H; Walck, C; Washbrook, A J; Weiser, C; Wetherell, Alan M; Wicke, D; Wickens, J; Wilkinson, G; Winter, M; Witek, M; Wlodek, T; Yi, J; Yushchenko, O P; Zaitsev, A; Zalewska-Bak, A; Zalewski, P; Zavrtanik, D; Zevgolatakos, E; Zhuravlov, V; Zimin, N I; Zintchenko, A; Zoller, P; Zucchelli, G C; Zumerle, G; Zupan, M; Acciarri, M; Achard, P; Adriani, O; Aguilar-Benítez, M; Alcaraz, J; Alemanni, G; Allaby, James V; Aloisio, A; Alviggi, M G; Ambrosi, G; Anderhub, H; Andreev, V P; Angelescu, T; Anselmo, F; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Bajo, A; Baksay, G; Baksay, L; Balandras, A; Baldew, S V; Ball, R C; Banerjee, S; Banerjee, Sw; Barczyk, A; Barillère, R; Barone, L; Bartalini, P; Basile, M; Batalova, N; Battiston, R; Bay, A; Becattini, F; Behner, F; Bellucci, L; Berbeco, R; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Bhattacharya, S; Biasini, M; Biglietti, M; Biland, A; Blaising, J J; Blyth, S C; Bobbink, G J; Böhm, A; Boldizsar, L; Borgia, B; Bottai, S; Bourilkov, D; Bourquin, M; Braccini, S; Branson, J G; Brigljevic, V; Brochu, F; Brock, I C; Buffini, A; Buijs, A; Burger, J D; Burger, W J; Button, A J; Cai, X D; Campanelli, M; Capell, M; Cara Romeo, G; Carlino, G; Cartacci, A; Casaus, J; Castellini, G; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada, M; Cesaroni, F; Chamizo-Llatas, M; Chang, Y H; Chaturvedi, U K; Chemarin, M; Chen, A; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chiefari, G; Cifarelli, L; Cindolo, F; Civinini, C; Clare, I; Clare, R; Coignet, G; Colijn, A P; Colino, N; Costantini, S; Cotorobai, F; Cozzoni, B; de la Cruz, B; Csilling, A; Cucciarelli, S; Dai, T S; van Dalen, J A; D'Alessandro, R; De Asmundis, R; Debreczeni, J; Deglon, P; Degré, A; Dehmelt, K; Deiters, K; Della Volpe, D; Delmeire, E; Denes, P; De Notaristefani, F; De Salvo, A; Diemoz, M; Dierckxsens, M; Van Dierendonck, D N; Di Lodovico, F; Dionisi, C; Dittmar, M; Dominguez, A; Doria, A; Dova, M T; Duchesneau, D; Dufournaud, D; Duda, M; Duinker, P; Durán, I; Dutta, S; Echenard, B; Eline, A; El-Hage, A; El-Mamouni, H; Engler, A; Eppling, F J; Erné, F C; Extermann, P; Fabre, M; Faccini, R; Falagán, M A; Falciano, S; Favara, A; Fay, J; Fedin, O; Felcini, M; Ferguson, T; Ferroni, F; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, F; Fisher, P H; Fisher, W; Fisk, I; Forconi, G; Fredj, L; Freudenreich, Klaus; Furetta, C; Galaktionov, Yu; Ganguli, S N; García-Abia, P; Gataullin, M; Gau, S S; Gentile, S; Gheordanescu, N; Giagu, S; Gong, Z F; Grenier, G; Grimm, O; Grünewald, M W; Guida, M; van Gulik, R; Gupta, V K; Gurtu, A; Gutay, L J; Haas, D; Hasan, A; Hatzifotiadou, D; Hebbeker, T; Hervé, A; Hidas, P; Hirschfelder, J; Hofer, H; Hohlmann, M; Holzner, G; Hoorani, H; Hou, S R; Iashvili, I; Innocente, V; Jin, B N; Jindal, P; Jones, L W; de Jong, P; Josa-Mutuberria, I; Khan, R A; Kaur, M; Kienzle-Focacci, M N; Kim, D; Kim, J K; Kirkby, Jasper; Kiss, D; Kittel, E W; Klimentov, A; König, A C; Koffeman, E; Kopal, M; Kopp, A; Koutsenko, V F; Kraber, M; Krämer, R W; Krenz, W; Krüger, A; Kuijten, H; Kunin, A; Ladrón de Guevara, P; Laktineh, I; Landi, G; Lassila-Perini, K M; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Lee, H J; Le Goff, J M; Leiste, R; Leonardi, E; Levtchenko, M; Levchenko, P M; Li, C; Likhoded, S; Lin, C H; Lin, W T; Linde, Frank L; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lü, Y S; Lu, W; Lübelsmeyer, K; Luci, C; Luckey, D; Luminari, L; Lugnier, L; Lustermann, W; Ma, W G; Maity, M; Malgeri, L; Malinin, A; Maña, C; Mangeol, D J J; Mans, J; Marchesini, P A; Marian, G; Martin, J P; Marzano, F; Massaro, G G G; Mazumdar, K; McNeil, R R; Mele, S; Merola, L; Merk, M; Meschini, M; Metzger, W J; Von der Mey, M; Mihul, A; Milcent, H; Mirabelli, G; Mnich, J; Mohanty, G B; Molnár, P; Monteleoni, B; Moulik, T; Muanza, G S; Muheim, F; Muijs, A J M; Musicar, B; Musy, M; Nagy, S; Natale, S; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Niessen, T; Nisati, A; Novák, T; Nowak, H; Ofierzynski, R A; Organtini, G; Oulianov, A; Pal, I; Palomares, C; Pandoulas, D; Paoletti, S; Paoloni, A; Paolucci, P; Paramatti, R; Park, H K; Park, I H; Pascale, G; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, F; Peach, D; Pedace, M; Pensotti, S; Perret-Gallix, D; Petersen, B; Piccolo, D; Pierella, F; Pieri, M; Pioppi, M; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Postema, H; Pothier, J; Produit, N; Prokofiev, D O; Prokofev, D; Quartieri, J; Rahal-Callot, G; Rahaman, M A; Raics, P; Raja, N; Ramelli, R; Rancoita, P G; Ranieri, R; Raspereza, A V; Razis, P; Ren, D; Rescigno, M; Reucroft, S; Van Rhee, T; Riemann, S; Riles, K; Robohm, A; Rodin, J; Roe, B P; Romero, L; Rosca, A; Rosemann, C; Rosenbleck, C; Rosier-Lees, S; Roth, S; Rubio, J A; Ruggiero, G; Ruschmeier, D; Rykaczewski, H; Sakharov, A; Saremi, S; Sarkar, S; Salicio, J; Sánchez, E; Sanders, M P; Sarakinos, M E; Schäfer, C; Shchegelskii, V; Schmidt-Kärst, S; Schmitz, D; Schopper, Herwig Franz; Schotanus, D J; Schwering, G; Sciacca, C; Sciarrino, D; Seganti, A; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shumilov, E; Shvorob, A; Siedenburg, T; Son, D; Smith, B; Souga, C; Spillantini, P; Steuer, M; Stickland, D P; Stone, A; Stone, H; Stoyanov, B; Strässner, A; Sudhakar, K; Sultanov, G G; Sun, L Z; Sushkov, S; Suter, H; Swain, J D; Szillási, Z; Sztaricskai, T; Tang, X W; Tarjan, P; Tauscher, L; Taylor, L; Tellili, B; Teyssier, D; Timmermans, C; Ting, Samuel C C; Ting, S M; Tonwar, S C; Tóth, J; Tully, C; Tung, K L; Uchida, Y; Ulbricht, J; Uwer, U; Valente, E; Van de Walle, R T; Vásquez, R; Veszpremi, V; Vesztergombi, G; Vetlitskii, I; Vicinanza, D; Viertel, G; Villa, S; Vivargent, M; Vlachos, S; Vodopyanov, I; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Vorvolakos, A; Wadhwa, M; Wallraff, W; Wang, Q; Wang, X L; Wang, Z M; Weber, A; Weber, M; Wienemann, P; Wilkens, H; Wu, S X; Wynhoff, S; Xia, L; Xu, Z Z; Yamamoto, J; Yang, B Z; Yang, C G; Yang, H J; Yang, M; Ye, J B; Yeh, S C; You, J M; Zalite, A; Zalite, Yu; Zhang, Z P; Zhao, J; Zhu, G Y; Zhu, R Y; Zhuang, H L; Zichichi, A; Zilizi, G; Zimmermann, B; Zöller, M; Abbiendi, G; Ainsley, C; Åkesson, P F; Alexander, G; Allison, J; Altekamp, N; Amaral, P; Ametewee, K A; Anagnostou, G; Anderson, K J; Anderson, S; Arcelli, S; Armitage, J C; Asai, S; Ashby, S F; Ashton, P; Astbury, A; Axen, D; Azuelos, Georges; Bahan, G A; Bailey, I; Baines, J T M; Ball, A H; Banks, J; Barillari, T; Barker, G J; Barlow, R J; Barnett, S; Bartoldus, R; Batley, J Richard; Beaudoin, G; Bechtle, P; Bechtluft, J; Beck, A; Becker, J; Beeston, C; Behnke, T; Bell, A N; Bell, K W; Bell, P J; Bella, G; Bellerive, A; Benelli, G; Bentvelsen, Stanislaus Cornelius Maria; Berlich, P; Bethke, Siegfried; Biebel, O; Binder, U; Blobel, Volker; Bloodworth, Ian J; Bloomer, J E; Bock, P; Boden, B; Böhme, J; Boeriu, O; Bonacorsi, D; Bosch, H M; Bougerolle, S; Boutemeur, M; Bouwens, B T; Brabson, B B; Braibant, S; Breuker, H; Brigliadori, L; Brown, R M; Brun, R; Bürgin, R; Büsser, K; Burckhart, H J; Burgard, C; Cammin, J; Campana, S; Capiluppi, P; Carnegie, R K; Caron, B; Carter, A A; Carter, J R; Chang, C Y; Charlesworth, C; Charlton, D G; Chrin, J T M; Chrisman, D; Chu, S L; Ciocca, C; Clarke, P E L; Clay, E; Clayton, J C; Cohen, I; Collins, W J; Conboy, J E; Cooke, O C; Cooper, M; Couch, M; Couchman, J; Coupland, M; do Couto e Silva, E; Coxe, R L; Cuffiani, M; Dado, S; Dallapiccola, C; Dallavalle, G M; Dallison, S; Darling, C; De Jong, S; de Roeck, A; De Wolf, E A; Debu, P; Deng, H; Deninno, M M; Dervan, P; Desch, Klaus; Dieckmann, A; Dienes, B; Dixit, M S; Donkers, M; Doucet, M; Dubbert, J; Duchovni, E; Duckeck, G; Duerdoth, I P; Dumas, D J P; Eckerlin, G; Edwards, J E G; Elcombe, P A; Estabrooks, P G; Evans, H G; Evans, M; Fabbri, F; Fanti, M; Fath, P; Feld, L; Fiedler, F; Fierro, M; Fincke-Keeler, M; Fischer, H M; Fleck, I; Folman, R; Fong, D G; Ford, M; Foucher, M; Frey, A; Fürtjes, A; Fukui, H; Fukunaga, C; Futyan, D I; Gagnon, P; Gaidot, A; Ganel, O; Gary, J W; Gascon, J; Gascon-Shotkin, S M; Gaycken, G; Geddes, N I; Geich-Gimbel, C; Gensler, S W; Gentit, F X; Geralis, T; Giacomelli, G; Giacomelli, P; Giacomelli, R; Gibson, V; Gibson, W R; Gillies, James D; Gingrich, D M; Giunta, M; Glenzinski, D A; Goldberg, J; Goodrick, M J; Gorn, W; Graham, K; Grandi, C; Grant, F C; Gross, E; Grunhaus, Jacob; Gruwé, M; Günther, P O; Sen-Gupta, A; Hagemann, J; Hajdu, C; Hamann, M; Hanson, G G; Hansroul, M; Hapke, M; Harder, K; Harel, A; Hargrove, C K; Harin-Dirac, M; Harrison, P F; Hart, P A; Hartmann, C; Hattersley, P M; Hauschild, M; Hawkes, C M; Hawkings, R; Heflin, E; Hemingway, R J; Hensel, C; Herten, G; Heuer, R D; Hill, J C; Hillier, S J; Hilse, T; Hinshaw, D A; Ho, C; Hoare, J; Hobbs, J D; Hobson, P R; Hochman, D; Höcker, Andreas; Hoffman, K; Holl, B; Homer, R J; Honma, A K; Horváth, D; Hossain, K R; Howard, R; Howarth, C P; Hüntemeyer, P; Hughes-Jones, R E; Humbert, R; Igo-Kemenes, P; Ihssen, H; Imrie, D C; Ingram, M R; Ishii, K; Jacob, F R; Janissen, A C; Jawahery, A; Jeffreys, P W; Jeremie, H; Jimack, M; Jobes, M; Joly, A; Jones, C R; Jones, G; Jones, M; Jost, U; Jovanovic, P; Jui, C; Kanaya, N; Kanzaki, J; Karapetian, G V; Karlen, D; Kartvelishvili, V G; Kawagoe, K; Kawamoto, T; Keeler, R K; Kellogg, R G; Kennedy, B W; Kim, D H; King, B J; Kirk, J; Klein, K; Kleinwort, C; Klem, D E; Klier, A; Kluth, S; Kobayashi, T; Kobel, M; Köpke, L; Koetke, D S; Kokott, T P; Komamiya, S; Kormos, L; Kowalewski, R V; Kramer, T; Kral, J F; Kress, T; Kreutzmann, H; Krieger, P; Von Krogh, J; Kroll, J; Krop, D; Krüger, K; Kühl, T; Kupper, M; Kuwano, M; Kyberd, P; Lafferty, G D; Lafoux, H; Lahmann, R; Lai, W P; Lamarche, F; Landsman, H; Lanske, D; Larson, W J; Lauber, J; Lautenschlager, S R; Lawson, I; Layter, J G; Lazic, D; Le Dû, P; Leblanc, P; Lee, A M; Lefebvre, E; Leins, A; Lellouch, D; Lennert, P; Leroy, C; Lessard, L; Letts, J; Levegrün, S; Levinson, L; Lewis, C; Liebisch, R; Lillich, J; Littlewood, C; Lloyd, A W; Lloyd, S L; Loebinger, F K; Long, G D; Lorah, J M; Lorazo, B; Losty, Michael J; Lou, X C; Lü, J; Ludwig, A; Ludwig, J; Luig, A; Macchiolo, A; MacPherson, A; Mader, W; Mättig, P; Malik, A; Mannelli, M; Marcellini, S; Marchant, T E; Maringer, G; Markus, C; Martin, A J; Martínez, G; Masetti, G; Mashimo, T; Matthews, W; Maur, U; McDonald, W J; McGowan, R F; McKenna, J; McKigney, E A; McMahon, T J; McNab, A I; McNutt, J R; McPherson, A C; McPherson, R A; Meijers, F; Méndez-Lorenzo, P; Menges, W; Menke, S; Menszner, D; Merritt, F S; Mes, H; Meyer, J; Meyer, N; Michelini, A; Middleton, R P; Mihara, S; Mikenberg, G; Mildenberger, J; Miller, D J; Milstene, C; Mir, R; Moed, S; Mohr, W; Moisan, C; Montanari, A; Mori, T; Moss, M W; Mouthuy, T; Murphy, P G; Mutter, A; Nagai, K; Nakamura, I; Nanjo, H; Neal, H A; Nellen, B; Nguyen, H H; Nijjhar, B; Nisius, R; Nozaki, M; Oakham, F G; Odorici, F; Ogg, M; Ögren, H O; Oh, A; Oh, H; Okpara, A; Oldershaw, N J; Omori, T; O'Neale, S W; O'Neill, B P; Oram, C J; Oreglia, M J; Orito, S; Pahl, C; Pálinkás, J; Palmonari, F; Pansart, J P; Panzer-Steindel, B; Paschievici, P; Pásztor, G; Pater, J R; Patrick, G N; Pawley, S J; Paz-Jaoshvili, N; Pearce, M J; Petzold, S; Pfeifenschneider, P; Pfister, P; Pilcher, J E; Pinfold, J L; Pitman, D; Plane, D E; Poffenberger, P R; Poli, B; Polok, J; Pooth, O; Posthaus, A; Pouladdej, A; del Pozo, L A; Prebys, E; Pritchard, T W; Przybycien, M B; Przysiezniak, H; Quadt, A; Rabbertz, K; Raith, B; Redmond, M W; Rees, D L; Rembser, C; Renkel, P; Richards, G E; Rick, H; Rigby, D; Robins, S A; Robinson, D; Rodning, N; Rollnik, A; Roney, J M; Rooke, A M; Ros, E; Rosati, S; Roscoe, K; Rossberg, S; Rossi, A M; Rosvick, M; Routenburg, P; Rozen, Y; Runge, K; Runólfsson, O; Ruppel, U; Rust, D R; Rylko, R; Sachs, K; Saeki, T; Sahr, O; Sanghera, S; Sarkisyan-Grinbaum, E; Sasaki, M; Sbarra, C; Schaile, A D; Schaile, O; Schappert, W; Scharf, F; Scharff-Hansen, P; Schenk, P; Schieck, J; von der Schmitt, H; Schmitt, S; Schörner-Sadenius, T; Schreiber, S; Schröder, M; Schütz, P; Schultz-Coulon, H C; Schulz, M; Schumacher, M; Schwarz, J; Schwick, C; Scott, W G; Settles, M; Seuster, R; Shears, T G; Shen, B C; Shepherd-Themistocleous, C H; Sherwood, P; Shypit, R; Simon, A; Singh, P; Siroli, G P; Sittler, A; Skillman, A; Skuja, A; Smith, A M; Smith, T J; Snow, G A; Sobie, R J; Söldner-Rembold, S; Spagnolo, S; Spanó, F; Springer, R W; Sproston, M; Starks, M; Steiert, M; Stephens, K; Steuerer, J; Stier, H E; Stockhausen, B; Stoll, K; Ströhmer, R; Strom, D; Strumia, F; Stumpf, L; Surrow, B; Szymanski, P; Tafirout, R; Takeda, H; Takeshita, T; Talbot, S D; Tanaka, S; Taras, P; Tarem, S; Tasevsky, M; Taylor, R J; Tecchio, M; Tesch, N; Teuscher, R; Thackray, N J; Thiergen, M; Thomson, M A; Von Törne, E; Towers, S; Toya, D; Trócsányi, Z L; Tran, P; Trefzger, T; Tresilian, N J; Trigger, I; Tscheulin, M; Tsukamoto, T; Tsur, E; Turcot, A S; Turner-Watson, M F; Tysarczyk-Niemeyer, G; Ueda, I; Ujvári, B; Utzat, P; Vachon, B; Van den Plas, D; Van Kooten, R; VanDalen, G J; Vannerem, P; Vasseur, G; Vertesi, R; Verzocchi, M; Vikas, P; Vincter, M G; Virtue, C J; Vokurka, E H; Vollmer, C F; Voss, H; Vossebeld, Joost Herman; Wäckerle, F; Wagner, A; Wagner, D L; Wahl, C; Walker, J P; Waller, D; Ward, C P; Ward, D R; Watkins, P M; Watson, A T; Watson, N K; Weber, P; Weisz, S; Wells, P S; Wengler, T; Wermes, N; Wetterling, D; Weymann, M; Whalley, M A; White, J S; Wilkens, B; Wilson, J A; Wilson, G W; Wingerter, Isabelle; Winterer, V H; Wood, N C; Wotton, S; Wyatt, T R; Yaari, R; Yamashita, S; Yang, Y; Yeaman, A; Yekutieli, G; Yurko, M; Zacek, V; Zacharov, I E; Zer-Zion, D; Zeuner, W; Zivkovic, L; Zorn, G T; Abe, Kenji; Abe, Koya; Abe, T; Abt, I; Acton, P D; Adam, I; Agnew, G; Akagi, T; Akimoto, H; Allen, N J; Ash, W W; Aston, D; Bacchetta, N; Baird, K G; Baltay, C; Band, H R; Barakat, M B; Baranko, G J; Bardon, O; Barklow, T L; Bashindzhagian, G L; Bauer, J M; Bazarko, A O; Bean, A; Bellodi, G; Ben-David, R; Berger, R; Bienz, T; Bilei, G M; Bisello, D; Blaylock, G; Bogart, J R; Bolen, B; Bolton, T; Bower, G R; Brau, J E; Breidenbach, M; Bugg, W M; Burke, D; Burnett, T H; Burrows, P N; Busza, W; Calcaterra, A; Caldwell, D O; Camanzi, B; Carpinelli, M; Cassell, R; Castaldi, R; Castro, A; Cavalli-Sforza, M; Chadwick, George B; Chou, A; Church, E; Claus, R; Cohn, H O; Coller, J A; Convery, M R; Cook, V; Cotton, R; Cowan, R F; Coyne, D G; Crawford, G; de Oliveira, A; Damerell, C J S; Daoudi, M; Dasu, S; De Groot, N; De Sangro, R; De Simone, P; De Simone, S; Dervan, P J; Dima, M; Dong, D N; Doser, Michael; Du, P Y C; Dubois, R; Duboscq, J E; Eisenstein, B I; Elia, R; Erdos, E; Erofeeva, I; Eschenburg, V; Etzion, E; Fahey, S; Falciai, D; Fan, C; Fernández, J P; Fero, M J; Flood, K; Frey, R; Friedman, Jerome Isaac; Furuno, K; Garwin, E L; Gillman, T; Gladding, G; Hallewell, G D; Hart, E L; Hasegawa, Y; Hasuko, K; Hedges, S; Hertzbach, S S; Hildreth, M D; Hitlin, D G; Honma, A; Huber, J S; Huffer, M E; Hughes, E W; Huynh, X; Hwang, H; Iwasaki, M; Iwasaki, Y; Izen, J M; Jackson, D J; Jacques, P; Jaros, J A; Jiang, Z Y; Johnson, A S; Johnson, J R; Johnson, R A; Junk, T R; Kajikawa, R; Kalelkar, M; Kamyshkov, Yu A; Kang, H J; Karliner, I; Kawahara, H; Kelsey, M H; Kendall, H W; Kim, Y D; King, M; King, R; Kofler, R R; Krishna, N M; Kwon, Y; Labs, J F; Kroeger, R S; Langston, M; Lath, A; Lauber, J A; Leith, D W G S; Lia, V; Lin, C; Liu, M X; Loreti, M; Lu, A; Lynch, H L; Ma, J; Mancinelli, G; Manly, S; Mantovani, G C; Markiewicz, T W; Maruyama, T; Masuda, H; Mazzucato, E; McGowan, J F; McKemey, A K; Meadows, B T; Messner, R; Mockett, P M; Moffeit, K C; Moore, T B; Morii, M; Mours, B; Müller, D; Müller, G; Murzin, V; Nagamine, T; Narita, S; Nauenberg, U; Neal, H; Nesom, G; Nussbaum, M; Ohnishi, Y; Oishi, N; Onoprienko, D; Osborne, L S; Panvini, R S; Park, C H; Park, H; Pavel, T J; Peruzzi, I; Pescara, L; Piccolo, M; Piemontese, L; Pieroni, E; Pitts, K T; Plano, R J; Prepost, R; Prescott, C Y; Punkar, G; Quigley, J; Ratcliff, B N; Reeves, K; Reeves, T W; Reidy, J; Reinertsen, P L; Rensing, P E; Rochester, L S; Rowson, P C; Russell, J J; Saxton, O H; Schalk, T; Schindler, R H; Schneekloth, U; Schumm, B A; Schwiening, J; Seiden, A; Sen, S; Serbo, V V; Shaevitz, M H; Shank, J T; Shapiro, G; Sherden, D J; Shmakov, K D; Simopoulos, C; Sinev, N B; Smith, S R; Smy, M B; Snyder, J A; Sokoloff, M D; Stängle, H; Stahl, A; Stamer, P; Steiner, H; Steiner, R; Strauss, M G; Su, D; Suekane, F; Sugiyama, A; Suzuki, A; Suzuki, S; Swartz, M; Szumilo, A; Takahashi, T; Taylor, F E; Thaler, J J; Thom, J; Torrence, E; Trandafir, A I; Turk, J D; Usher, T; Vavra, J; Vella, E; Venuti, J P; Verdier, R; Wagner, S R; Waite, A P; Walston, S; Wang, J; Watts, S J; Weidemann, A W; Weiss, E R; Whitaker, J S; White, S L; Wickens, F J; Williams, D A; Williams, D C; Williams, S H; Willocq, S; Wilson, R J; Wisniewski, W J; Wittlin, J L; Woods, M; Word, G B; Wright, T R; Wyss, J; Yamamoto, R K; Yang, X Q; Yashima, J; Yellin, S J; Young, C C; Yuta, H; Zapalac, G; Zdarko, R W; Zeitlin, C; Zhou, J

    2006-01-01

    We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLD experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, $MZ$ and $GZ$, and its couplings to fermions, for example the $ ho$ parameter and the effective electroweak mixing angle for leptons, are precisely measured: egin{eqnarray*} MZ & = & 91.1875 pm 0.0021~GeV \\ GZ & = & 2.4952 pm 0.0023~GeV \\ ho_ell & = & 1.0050 pm 0.0010 \\ swsqeffl & =& 0.23153 pm 0.00016 ,. end{eqnarray*} The number of light neutrino species is determined to be $2.9840pm0.0082$, in agreement with the three observed generations of fundamental fermions. The results are compared to the pr...

  16. Precision Laser Annealing of Focal Plane Arrays

    Energy Technology Data Exchange (ETDEWEB)

    Bender, Daniel A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); DeRose, Christopher [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Starbuck, Andrew Lea [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Verley, Jason C. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jenkins, Mark W. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-09-01

    We present results from laser annealing experiments in Si using a passively Q-switched Nd:YAG microlaser. Exposure with laser at fluence values above the damage threshold of commercially available photodiodes results in electrical damage (as measured by an increase in photodiode dark current). We show that increasing the laser fluence to values in excess of the damage threshold can result in annealing of a damage site and a reduction in detector dark current by as much as 100x in some cases. A still further increase in fluence results in irreparable damage. Thus we demonstrate the presence of a laser annealing window over which performance of damaged detectors can be at least partially reconstituted. Moreover dark current reduction is observed over the entire operating range of the diode indicating that device performance has been improved for all values of reverse bias voltage. Additionally, we will present results of laser annealing in Si waveguides. By exposing a small (<10 um) length of a Si waveguide to an annealing laser pulse, the longitudinal phase of light acquired in propagating through the waveguide can be modified with high precision, <15 milliradian per laser pulse. Phase tuning by 180 degrees is exhibited with multiple exposures to one arm of a Mach-Zehnder interferometer at fluence values below the morphological damage threshold of an etched Si waveguide. No reduction in optical transmission at 1550 nm was found after 220 annealing laser shots. Modeling results for laser annealing in Si are also presented.

  17. An LCD tachistoscope with submillisecond precision.

    Science.gov (United States)

    Sperdin, Holger F; Repnow, Marc; Herzog, Michael H; Landis, Theodor

    2013-12-01

    Tachistoscopes allow brief visual stimulation delivery, which is crucial for experiments in which subliminal presentation is required. Up to now, tachistoscopes have had shortcomings with respect to timing accuracy, reliability, and flexibility of use. Here, we present a new and inexpensive two-channel tachistoscope that allows for exposure durations in the submillisecond range with an extremely high timing accuracy. The tachistoscope consists of two standard liquid-crystal display (LCD) monitors of the light-emitting diode (LED) backlight type, a semipermeable mirror, a mounting rack, and an experimental personal computer (PC). The monitors have been modified to provide external access to the LED backlights, which are controlled by the PC via the standard parallel port. Photodiode measurements confirmed reliable operation of the tachistoscope and revealed switching times of 3 μs. Our method may also be of great advantage in single-monitor setups, in which it allows for manipulating the stimulus timing with submillisecond precision in many experimental situations. Where this is not applicable, the monitor can be operated in standard mode by disabling the external backlight control instantaneously.

  18. LHC Power Converters: A Precision Game

    CERN Multimedia

    2001-01-01

    The LHC test-bed, String 2, is close to commissioning and one important element to get a first chance to prove what it can do is the power converter system. In String 2 there are 16 converters, in the full LHC there will be almost 1800. This article takes a look at what is so special about the power converters for the LHC. The 13 000 Amps power converters with the watercooled cables going to the String 2 feedboxes. The LHC's superconducting magnets will be the pinnacle of high technology. But to work, they'll need the help of high-precision power converters to supply them with extremely stable DC current. Perfection will be the name of the game, with an accuracy of just 1-2 parts per million (ppm) required. LEP, for the sake of comparison, could live with 10-20 ppm. The LHC's power converters will be very different from those of LEP or the SPS since the new accelerator's magnets are mostly superconducting. That means that they require much higher currents at a lower voltage since superconductors have no re...

  19. Precision medicine: The future in diabetes care?

    Science.gov (United States)

    Scheen, André J

    2016-07-01

    Personalized medicine aims at better targeting therapeutic intervention to the individual to maximize benefit and minimize harm. Type 2 diabetes (T2D) is a heterogeneous disease from a genetic, pathophysiological and clinical point of view. Thus, the response to any antidiabetic medication may considerably vary between individuals. Numerous glucose-lowering agents, with different mechanisms of action, have been developed, a diversified armamentarium that offers the possibility of a patient-centred therapeutic approach. In the current clinical practice, a personalized approach is only based upon phenotype, taking into account patient and disease individual characteristics. If this approach may help increase both efficacy and safety outcomes, there remains considerable room for improvement. In recent years, many efforts were taken to identify genetic and genotype SNP's (Single Nucleotide Polymorphism's) variants that influence the pharmacokinetics, pharmacodynamics, and ultimately the therapeutic response of oral glucose-lowering drugs. This approach mainly concerns metformin, sulphonylureas, meglitinides and thiazolidinediones, with only scarce data concerning gliptins and gliflozins yet. However, the contribution of pharmacogenetics and pharmacogenomics to personalized therapy still needs to mature greatly before routine clinical implementation is possible. This review discusses both opportunities and challenges of precision medicine and how this new paradigm may lead to a better individualized treatment of T2D. Copyright © 2016. Published by Elsevier Ireland Ltd.

  20. Precise GNSS Positioning Using Smart Devices

    Directory of Open Access Journals (Sweden)

    Eugenio Realini

    2017-10-01

    Full Text Available The recent access to GNSS (Global Navigation Satellite System phase observations on smart devices, enabled by Google through its Android operating system, opens the possibility to apply precise positioning techniques using off-the-shelf, mass-market devices. The target of this work is to evaluate whether this is feasible, and which positioning accuracy can be achieved by relative positioning of the smart device with respect to a base station. Positioning of a Google/HTC Nexus 9 tablet was performed by means of batch least-squares adjustment of L1 phase double-differenced observations, using the open source goGPS software, over baselines ranging from approximately 10 m to 8 km, with respect to both physical (geodetic or low-cost and virtual base stations. The same positioning procedure was applied also to a co-located u-blox low-cost receiver, to compare the performance between the receiver and antenna embedded in the Nexus 9 and a standard low-cost single-frequency receiver with external patch antenna. The results demonstrate that with a smart device providing raw GNSS phase observations, like the Nexus 9, it is possible to reach decimeter-level accuracy through rapid-static surveys, without phase ambiguity resolution. It is expected that sub-centimeter accuracy could be achieved, as demonstrated for the u-blox case, if integer phase ambiguities were correctly resolved.

  1. Precise GNSS Positioning Using Smart Devices.

    Science.gov (United States)

    Realini, Eugenio; Caldera, Stefano; Pertusini, Lisa; Sampietro, Daniele

    2017-10-24

    The recent access to GNSS (Global Navigation Satellite System) phase observations on smart devices, enabled by Google through its Android operating system, opens the possibility to apply precise positioning techniques using off-the-shelf, mass-market devices. The target of this work is to evaluate whether this is feasible, and which positioning accuracy can be achieved by relative positioning of the smart device with respect to a base station. Positioning of a Google/HTC Nexus 9 tablet was performed by means of batch least-squares adjustment of L1 phase double-differenced observations, using the open source goGPS software, over baselines ranging from approximately 10 m to 8 km, with respect to both physical (geodetic or low-cost) and virtual base stations. The same positioning procedure was applied also to a co-located u-blox low-cost receiver, to compare the performance between the receiver and antenna embedded in the Nexus 9 and a standard low-cost single-frequency receiver with external patch antenna. The results demonstrate that with a smart device providing raw GNSS phase observations, like the Nexus 9, it is possible to reach decimeter-level accuracy through rapid-static surveys, without phase ambiguity resolution. It is expected that sub-centimeter accuracy could be achieved, as demonstrated for the u-blox case, if integer phase ambiguities were correctly resolved.

  2. Light top partners and precision physics

    CERN Document Server

    Grojean, Christophe; Panico, Giuliano

    2013-01-01

    We analyze the corrections to the precision EW observables in minimal composite Higgs models by using a general effective parametrization which also includes the lightest fermionic resonances. A new, possibly large, logarithmically divergent contribution to S is identified, which comes purely from the strong dynamics. It can be interpreted as a running of S induced by the non-renormalizable Higgs interactions due to the non-linear sigma-model structure. As expected, the corrections to the T parameter coming from fermion loops are finite and dominated by the contributions of the lightest composite states. The fit of the oblique parameters suggests a rather stringent lower bound on the sigma-model scale f > 750GeV. The corrections to the Z bL bL vertex coming from the lowest-order operators in the effective Lagrangian are finite and somewhat correlated to the corrections to T. Large additional contributions are generated by contact interactions with 4 composite fermions. In this case a logarithmic divergence ca...

  3. Pharmacometabolomics informs viromics towards precision medicine

    Directory of Open Access Journals (Sweden)

    Aggeliki Balasopoulou

    2016-10-01

    Full Text Available Nowadays, we are experiencing the big data era with the emerging challenge of single data interpretation. Although the advent of high-throughput technologies as well as chemo- and bio- informatics tools presents pan-omics data as the way forward to precision medicine, personalized health care and tailored-made therapeutics can be only envisaged when interindividual variability in response to/ toxicity of xenobiotics can be interpreted and thus, predicted. We know that such variability is the net outcome of genetics (host and microbiota and environmental factors (diet, lifestyle, polypharmacy, microbiota and for this, tremendous efforts have been made to clarify key-molecules from correlation to causality to clinical significance. Herein, we focus on the host-microbiome interplay and its direct and indirect impact on efficacy and toxicity of xenobiotics and we inevitably wonder about the role of viruses, as the least acknowledged ones. We present the emerging discipline of pharmacometabolomics-informed viromics, in which pre-dose metabotypes can assist modeling and prediction of interindividual response to/ toxicity of xenobiotics. Such features, either alone or in combination with host genetics, can power biomarker discovery so long as the features are variable among patients, stable enough to be of predictive value, and better than pre-existing tools for predicting therapeutic efficacy/ toxicity.

  4. Quantum dots with single-atom precision.

    Science.gov (United States)

    Fölsch, Stefan; Martínez-Blanco, Jesús; Yang, Jianshu; Kanisawa, Kiyoshi; Erwin, Steven C

    2014-07-01

    Quantum dots are often called artificial atoms because, like real atoms, they confine electrons to quantized states with discrete energies. However, although real atoms are identical, most quantum dots comprise hundreds or thousands of atoms, with inevitable variations in size and shape and, consequently, unavoidable variability in their wavefunctions and energies. Electrostatic gates can be used to mitigate these variations by adjusting the electron energy levels, but the more ambitious goal of creating quantum dots with intrinsically digital fidelity by eliminating statistical variations in their size, shape and arrangement remains elusive. We used a scanning tunnelling microscope to create quantum dots with identical, deterministic sizes. By using the lattice of a reconstructed semiconductor surface to fix the position of each atom, we controlled the shape and location of the dots with effectively zero error. This allowed us to construct quantum dot molecules whose coupling has no intrinsic variation but could nonetheless be tuned with arbitrary precision over a wide range. Digital fidelity opens the door to quantum dot architectures free of intrinsic broadening-an important goal for technologies from nanophotonics to quantum information processing as well as for fundamental studies of confined electrons.

  5. Precision measurement of $D$ meson mass differences

    CERN Document Server

    INSPIRE-00258707; Abellan Beteta, C; Adeva, B; Adinolfi, M; Adrover, C; Affolder, A; Ajaltouni, Z; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves Jr, A A; Amato, S; Amerio, S; Amhis, Y; Anderlini, L; Anderson, J; Andreassen, R; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Bachmann, S; Back, J J; Baesso, C; Balagura, V; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Bauer, Th; Bay, A; Beddow, J; Bedeschi, F; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Benayoun, M; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bettler, M -O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Bowcock, T J V; Bowen, E; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brook, N H; Brown, H; Burducea, I; Bursche, A; Busetto, G; Buytaert, J; Cadeddu, S; Callot, O; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Campora Perez, D; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carranza-Mejia, H; Carson, L; Carvalho Akiba, K; Casse, G; Cattaneo, M; Cauet, Ch; Charles, M; Charpentier, Ph; Chen, P; Chiapolini, N; Chrzaszcz, M; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coca, C; Coco, V; Cogan, J; Cogneras, E; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Coquereau, S; Corti, G; Couturier, B; Cowan, G A; Craik, D C; Cunliffe, S; Currie, R; D'Ambrosio, C; David, P; David, P N Y; Davis, A; De Bonis, I; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Silva, W; De Simone, P; Decamp, D; Deckenhoff, M; Del Buono, L; Derkach, D; Deschamps, O; Dettori, F; Di Canto, A; Dijkstra, H; Dogaru, M; Donleavy, S; Dordei, F; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dupertuis, F; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; van Eijk, D; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Elsby, D; Falabella, A; Färber, C; Fardell, G; Farinelli, C; Farry, S; Fave, V; Ferguson, D; Fernandez Albor, V; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fiore, M; Fitzpatrick, C; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Furcas, S; Furfaro, E; Gallas Torreira, A; Galli, D; Gandelman, M; Gandini, P; Gao, Y; Garofoli, J; Garosi, P; Garra Tico, J; Garrido, L; Gaspar, C; Gauld, R; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gibson, V; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gordon, H; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hampson, T; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; Hartmann, T; He, J; Heijne, V; Hennessy, K; Henrard, P; Hernando Morata, J A; van Herwijnen, E; Hicks, E; Hill, D; Hoballah, M; Hombach, C; Hopchev, P; Hulsbergen, W; Hunt, P; Huse, T; Hussain, N; Hutchcroft, D; Hynds, D; Iakovenko, V; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jans, E; Jaton, P; Jing, F; John, M; Johnson, D; Jones, C R; Jost, B; Kaballo, M; Kandybei, S; Karacson, M; Karbach, T M; Kenyon, I R; Kerzel, U; Ketel, T; Keune, A; Khanji, B; Kochebina, O; Komarov, I; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kucharczyk, M; Kudryavtsev, V; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J -P; Lefèvre, R; Leflat, A; Lefrançois, J; Leo, S; Leroy, O; Lesiak, T; Leverington, B; Li, Y; Li Gioi, L; Liles, M; Lindner, R; Linn, C; Liu, B; Liu, G; Lohn, S; Longstaff, I; Lopes, J H; Lopez Asamar, E; Lopez-March, N; Lu, H; Lucchesi, D; Luisier, J; Luo, H; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Malde, S; Manca, G; Mancinelli, G; Marconi, U; Märki, R; Marks, J; Martellotti, G; Martens, A; Martin, L; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Martins Tostes, D; Massafferri, A; Matev, R; Mathe, Z; Matteuzzi, C; Maurice, E; Mazurov, A; McCarthy, J; McNab, A; McNulty, R; Meadows, B; Meier, F; Meissner, M; Merk, M; Milanes, D A; Minard, M -N; Molina Rodriguez, J; Monteil, S; Moran, D; Morawski, P; Morello, M J; Mountain, R; Mous, I; Muheim, F; Müller, K; Muresan, R; Muryn, B; Muster, B; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neufeld, N; Nguyen, A D; Nguyen, T D; Nguyen-Mau, C; Nicol, M; Niess, V; Niet, R; Nikitin, N; Nikodem, T; Nomerotski, A; Novoselov, A; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Orlandea, M; Otalora Goicochea, J M; Owen, P; Oyanguren, A; Pal, B K; Palano, A; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Patrick, G N; Patrignani, C; Pavel-Nicorescu, C; Pazos Alvarez, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perego, D L; Perez Trigo, E; Pérez-Calero Yzquierdo, A; Perret, P; Perrin-Terrin, M; Pessina, G; Petridis, K; Petrolini, A; Phan, A; Picatoste Olloqui, E; Pietrzyk, B; Pilař, T; Pinci, D; Playfer, S; Plo Casasus, M; Polci, F; Polok, G; Poluektov, A; Polycarpo, E; Popov, D; Popovici, B; Potterat, C; Powell, A; Prisciandaro, J; Pugatch, V; Puig Navarro, A; Punzi, G; Qian, W; Rademacker, J H; Rakotomiaramanana, B; Rangel, M S; Raniuk, I; Rauschmayr, N; Raven, G; Redford, S; Reid, M M; dos Reis, A C; Ricciardi, S; Richards, A; Rinnert, K; Rives Molina, V; Roa Romero, D A; Robbe, P; Rodrigues, E; Rodriguez Perez, P; Roiser, S; Romanovsky, V; Romero Vidal, A; Rouvinet, J; Ruf, T; Ruffini, F; Ruiz, H; Ruiz Valls, P; Sabatino, G; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salzmann, C; Sanmartin Sedes, B; Sannino, M; Santacesaria, R; Santamarina Rios, C; Santovetti, E; Sapunov, M; Sarti, A; Satriano, C; Satta, A; Savrie, M; Savrina, D; Schaack, P; Schiller, M; Schindler, H; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M -H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Senderowska, K; Sepp, I; Serra, N; Serrano, J; Seyfert, P; Shapkin, M; Shapoval, I; Shatalov, P; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, O; Shevchenko, V; Shires, A; Silva Coutinho, R; Skwarnicki, T; Smith, N A; Smith, E; Smith, M; Sokoloff, M D; Soler, F J P; Soomro, F; Souza, D; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Stagni, F; Stahl, S; Steinkamp, O; Stoica, S; Stone, S; Storaci, B; Straticiuc, M; Straumann, U; Subbiah, V K; Swientek, S; Syropoulos, V; Szczekowski, M; Szczypka, P; Szumlak, T; T'Jampens, S; Teklishyn, M; Teodorescu, E; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Tonelli, D; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tresch, M; Tsaregorodtsev, A; Tsopelas, P; Tuning, N; Ubeda Garcia, M; Ukleja, A; Urner, D; Uwer, U; Vagnoni, V; Valenti, G; Vazquez Gomez, R; Vazquez Regueiro, P; Vecchi, S; Velthuis, J J; Veltri, M; Veneziano, G; Vesterinen, M; Viaud, B; Vieira, D; Vilasis-Cardona, X; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Vorobyev, V; Voß, C; Voss, H; Waldi, R; Wallace, R; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Webber, A D; Websdale, D; Whitehead, M; Wicht, J; Wiechczynski, J; Wiedner, D; Wiggers, L; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wishahi, J; Witek, M; Wotton, S A; Wright, S; Wu, S; Wyllie, K; Xie, Y; Xing, F; Xing, Z; Yang, Z; Young, R; Yuan, X; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, F; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhokhov, A; Zhong, L; Zvyagin, A

    2013-01-01

    Using three- and four-body decays of $D$ mesons produced in semileptonic $b$-hadron decays, precision measurements of $D$ meson mass differences are made together with a measurement of the $D^{0}$ mass. The measurements are based on a dataset corresponding to an integrated luminosity of 1.0 fb$^{-1}$ collected in $pp$ collisions at 7~TeV. Using the decay $D^0 \\rightarrow K^{+} K^{-} K^{-} \\pi^{+}$, the $D^0$ mass is measured to be \\begin{alignat*}{3} M(D^0) \\phantom{ghd} &=&~1864.75 \\pm 0.15 \\,({\\rm stat}) \\pm 0.11 \\,({\\rm syst}) \\, \\textrm{MeV}/c^2. \\end{alignat*} The mass differences \\begin{alignat*}{3} M(D^{+}) - M(D^{0}) &=& 4.76 \\pm 0.12 \\,({\\rm stat}) \\pm 0.07 \\,({\\rm syst}) \\, \\textrm{MeV}/c^2, \\\\ M(D^{+}_s) - M(D^{+}) &=& \\phantom{00}98.68 \\pm 0.03 \\,({\\rm stat}) \\pm 0.04 \\,({\\rm syst}) \\, \\textrm{MeV}/c^2 \\end{alignat*} are measured using the $D^0 \\rightarrow K^{+} K^{-} \\pi^{+} \\pi^{-}$ and $D^{+}_{(s)} \\rightarrow K^{+}K^{-} \\pi^{+}$ modes.

  6. Precision segmented reflectors for space applications

    Science.gov (United States)

    Lehman, David H.; Pawlik, Eugene V.; Meinel, Aden B.; Fichter, W. B.

    1990-08-01

    A project to develop precision segmented reflectors (PSRs) which operate at submillimeter wavelengths is described. The development of a light efficient means for the construction of large-aperture segmented reflecting space-based telescopes is the primary aim of the project. The 20-m Large Deployable Reflector (LDR) telescope is being developed for a survey mission, and it will make use of the reflector panels and materials, structures, and figure control being elaborated for the PSR. The surface accuracy of a 0.9-m PSR panel is shown to be 1.74-micron RMS, the goal of 100-micron RMS positioning accuracy has been achieved for a 4-m erectable structure. A voice-coil actuator for the figure control system architecture demonstrated 1-micron panel control accuracy in a 3-axis evaluation. The PSR technology is demonstrated to be of value for several NASA projects involving optical communications and interferometers as well as missions which make use of large-diameter segmented reflectors.

  7. Precision Electrophile Tagging in Caenorhabditis elegans.

    Science.gov (United States)

    Long, Marcus J C; Urul, Daniel A; Chawla, Shivansh; Lin, Hong-Yu; Zhao, Yi; Haegele, Joseph A; Wang, Yiran; Aye, Yimon

    2018-01-16

    Adduction of an electrophile to privileged sensor proteins and the resulting phenotypically dominant responses are increasingly appreciated as being essential for metazoan health. Functional similarities between the biological electrophiles and electrophilic pharmacophores commonly found in covalent drugs further fortify the translational relevance of these small-molecule signals. Genetically encodable or small-molecule-based fluorescent reporters and redox proteomics have revolutionized the observation and profiling of cellular redox states and electrophile-sensor proteins, respectively. However, precision mapping between specific redox-modified targets and specific responses has only recently begun to be addressed, and systems tractable to both genetic manipulation and on-target redox signaling in vivo remain largely limited. Here we engineer transgenic Caenorhabditis elegans expressing functional HaloTagged fusion proteins and use this system to develop a generalizable light-controlled approach to tagging a prototypical electrophile-sensor protein with native electrophiles in vivo. The method circumvents issues associated with low uptake/distribution and toxicity/promiscuity. Given the validated success of C. elegans in aging studies, this optimized platform offers a new lens with which to scrutinize how on-target electrophile signaling influences redox-dependent life span regulation.

  8. Precision Pulsar Timing at the DSN

    Science.gov (United States)

    Majid, Walid A.

    2016-01-01

    Millisecond pulsars are a class of radio pulsars with extremely stable rotations. The excellent timing stability of millisecond pulsars can be used to study a wide variety of astrophysical phenomena. In particular, observations of a large sample of these pulsars can be used to detect the presence of low-frequency gravitational waves. We have developed and are now commissioning a precision pulsar timing backend for the Deep Space Network (DSN), which will allow the use of short gaps in tracking schedules to observe and time pulses from an ensemble of millisecond pulsars. The NASA Deep Space Network (DSN) operates clusters of large dish antennas (up to 70-m in diameter), located roughly equi-distant around the Earth, for communication and tracking of deep-space spacecraft. The backend system is capable of removing entirely the dispersive effects of propagation of radio waves through the interstellar medium in real-time. We will describe our development work, initial results, and prospects for future observations scheduled over the next few years.

  9. Ultimate Precision of Adaptive Noise Estimation

    Science.gov (United States)

    Pirandola, Stefano; Lupo, Cosmo

    2017-03-01

    We consider the estimation of noise parameters in a quantum channel, assuming the most general strategy allowed by quantum mechanics. This is based on the exploitation of unlimited entanglement and arbitrary quantum operations, so that the channel inputs may be interactively updated. In this general scenario, we draw a novel connection between quantum metrology and teleportation. In fact, for any teleportation-covariant channel (e.g., Pauli, erasure, or Gaussian channel), we find that adaptive noise estimation cannot beat the standard quantum limit, with the quantum Fisher information being determined by the channel's Choi matrix. As an example, we establish the ultimate precision for estimating excess noise in a thermal-loss channel, which is crucial for quantum cryptography. Because our general methodology applies to any functional that is monotonic under trace-preserving maps, it can be applied to simplify other adaptive protocols, including those for quantum channel discrimination. Setting the ultimate limits for noise estimation and discrimination paves the way for exploring the boundaries of quantum sensing, imaging, and tomography.

  10. Differential Phase Detector for Precise Phase Alignment

    CERN Document Server

    Olexa, Jakub

    2016-01-01

    This paper presents a differential phase detector circuit, whose phase-to-voltage characteristic has an extremum when its two input signals are exactly in phase. In this condition all its digital signals are of 50 % duty cycle so that the circuit characteristic does not have a dead zone. This feature allows a precise indication of the zero-phase condition, which is independent of the detector power supply and the offset of its ADC readout. Such a detector is used for a phase alignment of two reference clock signals with frequency about 11 kHz in front-ends processing signals from beam position monitors of the Large Hadron Collider (LHC) at CERN. The detector output voltage is digitized with a 24-bit ADC at the rate of the reference signals. The resulting samples are processed in the front-end FPGA and transmitted to the control system using an Ethernet data stream. After a detailed description of the differential phase detector its performance is demonstrated with laboratory measurements. The results show tha...

  11. Are torque values of preadjusted brackets precise?

    Directory of Open Access Journals (Sweden)

    Alessandra Motta Streva

    Full Text Available OBJECTIVE: The aim of the present study was to verify the torque precision of metallic brackets with MBT prescription using the canine brackets as the representative sample of six commercial brands. MATERIAL AND METHODS: Twenty maxillary and 20 mandibular canine brackets of one of the following commercial brands were selected: 3M Unitek, Abzil, American Orthodontics, TP Orthodontics, Morelli and Ortho Organizers. The torque angle, established by reference points and lines, was measured by an operator using an optical microscope coupled to a computer. The values were compared to those established by the MBT prescription. RESULTS: The results showed that for the maxillary canine brackets, only the Morelli torque (-3.33º presented statistically significant difference from the proposed values (-7º. For the mandibular canines, American Orthodontics (-6.34º and Ortho Organizers (-6.25º presented statistically significant differences from the standards (-6º. Comparing the brands, Morelli presented statistically significant differences in comparison with all the other brands for maxillary canine brackets. For the mandibular canine brackets, there was no statistically significant difference between the brands. CONCLUSIONS: There are significant variations in torque values of some of the brackets assessed, which would clinically compromise the buccolingual positioning of the tooth at the end of orthodontic treatment.

  12. Precision for B-meson matrix elements

    Energy Technology Data Exchange (ETDEWEB)

    Guazzini, D.; Sommer, R. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); Tantalo, N. [INFN sezione ' ' Tor Vergata' ' , Rome (Italy)]|[Centro E. Fermi, Rome (Italy)

    2007-10-15

    We demonstrate how HQET and the Step Scaling Method for B-physics, pioneered by the Tor Vergata group, can be combined to reach a further improved precision. The observables considered are the mass of the b-quark and the B{sub s}-meson decay constant. The demonstration is carried out in quenched lattice QCD. We start from a small volume, where one can use a standard O(a)-improved relativistic action for the b-quark, and compute two step scaling functions which relate the observables to the large volume ones. In all steps we extrapolate to the continuum limit, separately in HQET and in QCD for masses below m{sub b}. The physical point m{sub b} is then reached by an interpolation of the continuum results in 1/m. The essential, expected and verified, feature is that the step scaling functions have a weak mass-dependence resulting in an easy interpolation to the physical point. With r{sub 0}=0.5 fm and the experimental B{sub s} and K masses as input, we find F{sub B{sub s}}=191(6) MeV and the renormalization group invariant mass M{sub b}=6.88(10) GeV, translating into anti m{sub b}(anti m{sub b})=4.42(6) GeV in the MS scheme. This approach seems very promising for full QCD. (orig.)

  13. Precise Lifetime Measurement of 37 K

    Science.gov (United States)

    Shidling, P. D.; Behling, R. S.; Hardy, J. C.; Iacob, V. E.; Mehlman, M.; Melconian, D.; Roeder, B. T.; Stephens, H.

    2011-04-01

    To determine the correlation parameters of the β decay of transitions between isobaric analogue states, the ft value is needed to determine ρ, the ratio of Gamow-Teller to Fermi matrix elements. A recent review of all T =1/2 β mirror decays [1] indicates that 37 K is one of the best candidates for testing the Standard Model. The ft value is currently limited by the 0.6% uncertainty in the lifetime. In order to make Standard Model predictions of the correlation parameters negligible compared to planned experiments, we have performed a precision lifetime measurement of 37 K. We used the MARS separator for producing a secondary beam of 37 K with a purity of 98.5%. We implanted the activity in an aluminized-Mylar tape that, as part of a fast-tape drive system, quickly transported the sample to a well shielded location, stopping it in the centre of a 4 π proportional gas counter. The recorded data was separated into 25 runs, each characterized by a different combination of detector high voltages, discriminator thresholds and dominant dead-time settings. An overview of the experiment and results will be presented.

  14. Cold Antihydrogen for Precise Laser Spectroscopy

    CERN Multimedia

    Gabrielse, G S; Walz, J; Hessels, E A; Tan, J; Oelert, W; George, M C; Grzonka, D J; Kossick, M; Storry, C H; Sefzick, T

    2002-01-01

    %AD-2 %title\\\\ \\\\The Antihydrogen TRAP Collaboration (ATRAP) seeks to do precise laser spectroscopy of antihydrogen. Comparisons of antihydrogen and hydrogen atoms should provide the most stringent test of CPT invariance involving baryons and leptons. ATRAP is an expansion of the TRAP collaboration that developed the techniques to take CERN antiprotons from an energy of 6 MeV (momentum 100 MeV/c) all the way down to thermal equilibrium at 4 K for storage. This storage energy is lower than realized previously by more than ten orders of magnitude. The TRAP techniques include slowing, capturing, electron cooling and stacking of antiprotons. ATRAP and other collaborations will use antiprotons from the Antiproton Decelerator (AD). This new facility makes sense for such experiments because we showed that antiprotons can be accumulated in a trap at much lower expense than was required in the earlier CERN AC-AA-LEAR complex. In the closest approach yet to the production of cold antihydrogen, collaboration members wer...

  15. Harnessing Solute Carrier Transporters for Precision Oncology.

    Science.gov (United States)

    Nyquist, Michael D; Prasad, Bhagwat; Mostaghel, Elahe A

    2017-03-28

    Solute Carrier (SLC) transporters are a large superfamily of transmembrane carriers involved in the regulated transport of metabolites, nutrients, ions and drugs across cellular membranes. A subset of these solute carriers play a significant role in the cellular uptake of many cancer therapeutics, ranging from chemotherapeutics such as antimetabolites, topoisomerase inhibitors, platinum-based drugs and taxanes to targeted therapies such as tyrosine kinase inhibitors. SLC transporters are co-expressed in groups and patterns across normal tissues, suggesting they may comprise a coordinated regulatory circuit serving to mediate normal tissue functions. In cancer however, there are dramatic changes in expression patterns of SLC transporters. This frequently serves to feed the increased metabolic demands of the tumor cell for amino acids, nucleotides and other metabolites, but also presents a therapeutic opportunity, as increased transporter expression may serve to increase intracellular concentrations of substrate drugs. In this review, we examine the regulation of drug transporters in cancer and how this impacts therapy response, and discuss novel approaches to targeting therapies to specific cancers via tumor-specific aberrations in transporter expression. We propose that among the oncogenic changes in SLC transporter expression there exist emergent vulnerabilities that can be exploited therapeutically, extending the application of precision medicine from tumor-specific drug targets to tumor-specific determinants of drug uptake.

  16. Comparison of solvent extraction and solid-phase extraction for the determination of polychlorinated biphenyls in transformer oil.

    Science.gov (United States)

    Mahindrakar, A N; Chandra, S; Shinde, L P

    2014-01-01

    Solid-phase extraction (SPE) of nine polychlorinated biphenyls (PCBs) from transformer oil samples was evaluated using octadecyl (CI8)-bonded porous silica. The efficiency of SPE of these PCBs was compared with those obtained by solvent extraction with DMSO and hexane. Average recoveries exceeding 95% for these PCBs were obtained via the SPE method using small cartridges containing 100mg of 40 pm CI8-bonded porous silica. The average recovery by solvent extraction with DMSO and hexane exceeded 83%. It was concluded that the recoveries and precision for the solvent extraction of PCBs were poorer than those for the SPE. Copyright © 2013 Elsevier Ltd. All rights reserved.

  17. 2007 Precision Strike Winter Roundtable - Precision Engagement - Strategic Context for the Long War

    Science.gov (United States)

    2007-02-01

    for Precision Engagement 11Lockheed Martin Aeronautics Company JASSM Reach Responsiveness Lethality Survivability $ Cost (Non-Recurring) Falcon RATTLRS...Germany, Italy, Japan, Kazakhstan , Turkey and Morocco Participating states make "a commitment and build capacities to prevent the acquisition of...Long Standing Assumption of US culture , politics ad law enforcement If terror states behind attacks: how do you arrest a country? Do you want a

  18. Unsupervised Extraction of Diagnosis Codes from EMRs Using Knowledge-Based and Extractive Text Summarization Techniques.

    Science.gov (United States)

    Kavuluru, Ramakanth; Han, Sifei; Harris, Daniel

    2013-05-01

    Diagnosis codes are extracted from medical records for billing and reimbursement and for secondary uses such as quality control and cohort identification. In the US, these codes come from the standard terminology ICD-9-CM derived from the international classification of diseases (ICD). ICD-9 codes are generally extracted by trained human coders by reading all artifacts available in a patient's medical record following specific coding guidelines. To assist coders in this manual process, this paper proposes an unsupervised ensemble approach to automatically extract ICD-9 diagnosis codes from textual narratives included in electronic medical records (EMRs). Earlier attempts on automatic extraction focused on individual documents such as radiology reports and discharge summaries. Here we use a more realistic dataset and extract ICD-9 codes from EMRs of 1000 inpatient visits at the University of Kentucky Medical Center. Using named entity recognition (NER), graph-based concept-mapping of medical concepts, and extractive text summarization techniques, we achieve an example based average recall of 0.42 with average precision 0.47; compared with a baseline of using only NER, we notice a 12% improvement in recall with the graph-based approach and a 7% improvement in precision using the extractive text summarization approach. Although diagnosis codes are complex concepts often expressed in text with significant long range non-local dependencies, our present work shows the potential of unsupervised methods in extracting a portion of codes. As such, our findings are especially relevant for code extraction tasks where obtaining large amounts of training data is difficult.

  19. Reliable low precision simulations in land surface models

    Science.gov (United States)

    Dawson, Andrew; Düben, Peter D.; MacLeod, David A.; Palmer, Tim N.

    2017-12-01

    Weather and climate models must continue to increase in both resolution and complexity in order that forecasts become more accurate and reliable. Moving to lower numerical precision may be an essential tool for coping with the demand for ever increasing model complexity in addition to increasing computing resources. However, there have been some concerns in the weather and climate modelling community over the suitability of lower precision for climate models, particularly for representing processes that change very slowly over long time-scales. These processes are difficult to represent using low precision due to time increments being systematically rounded to zero. Idealised simulations are used to demonstrate that a model of deep soil heat diffusion that fails when run in single precision can be modified to work correctly using low precision, by splitting up the model into a small higher precision part and a low precision part. This strategy retains the computational benefits of reduced precision whilst preserving accuracy. This same technique is also applied to a full complexity land surface model, resulting in rounding errors that are significantly smaller than initial condition and parameter uncertainties. Although lower precision will present some problems for the weather and climate modelling community, many of the problems can likely be overcome using a straightforward and physically motivated application of reduced precision.

  20. A precise modeling of Phoebe's rotation

    Science.gov (United States)

    Cottereau, L.; Aleshkina, E.; Souchay, J.

    2010-11-01

    Aims: Although the rotation of some Saturn's satellites in spin-orbit has already been studied by several authors, this is not the case for the rotation of Phoebe, which stands out because it is non-resonant. The purpose of the paper is to determine for the first time and with precision its precession-nutation motion. Methods: We adopt an Hamiltonian formalism of the rotation motion of rigid celestial bodies set up by Kinoshita (1977, Celest. Mech., 15, 277) based on Andoyer variables and canonical equations. First we calculate Phoebe's obliquity at J2000,0 from available astronomical data as well as the gravitational perturbation caused by Saturn on Phoebe's rotational motion. Then we carry out a numerical integration and compare our results for the precession rate and the nutation coefficients with a purely analytical model. Results: Our results for Phoebe's obliquity (23°95) and Phoebe's precession rate (5580.65 arcsec/cy) are very close to the respective values for the Earth. Moreover the amplitudes of the nutations (26” peak to peak for the nutaton in longitude and 8” for the nutation in obliquity) are on the same order as the respective amplitudes for the Earth. We give complete tables of nutation, obtained from a fast fourier transform (FFT) analysis starting from the numerical signals. We show that a purely analytical model of the nutation is not accurate because Phoebe's orbital elements e, M and LS do not show a simple linear behaviour at all. Conclusions: The precession and nutation of Phoebe have been calculated for the first time in this paper. We will continue this study in the future by studying the additional gravitational effects of the Sun, of the large satellites such as Titan, as well as Saturn's dynamical ellipticity.

  1. Interacting dark sector and precision cosmology

    Science.gov (United States)

    Buen-Abad, Manuel A.; Schmaltz, Martin; Lesgourgues, Julien; Brinckmann, Thejs

    2018-01-01

    We consider a recently proposed model in which dark matter interacts with a thermal background of dark radiation. Dark radiation consists of relativistic degrees of freedom which allow larger values of the expansion rate of the universe today to be consistent with CMB data (H0-problem). Scattering between dark matter and radiation suppresses the matter power spectrum at small scales and can explain the apparent discrepancies between ΛCDM predictions of the matter power spectrum and direct measurements of Large Scale Structure LSS (σ8-problem). We go beyond previous work in two ways: 1. we enlarge the parameter space of our previous model and allow for an arbitrary fraction of the dark matter to be interacting and 2. we update the data sets used in our fits, most importantly we include LSS data with full k-dependence to explore the sensitivity of current data to the shape of the matter power spectrum. We find that LSS data prefer models with overall suppressed matter clustering due to dark matter - dark radiation interactions over ΛCDM at 3–4 σ. However recent weak lensing measurements of the power spectrum are not yet precise enough to clearly distinguish two limits of the model with different predicted shapes for the linear matter power spectrum. In two appendices we give a derivation of the coupled dark matter and dark radiation perturbation equations from the Boltzmann equation in order to clarify a confusion in the recent literature, and we derive analytic approximations to the solutions of the perturbation equations in the two physically interesting limits of all dark matter weakly interacting or a small fraction of dark matter strongly interacting.

  2. Precision Casting via Advanced Simulation and Manufacturing

    Science.gov (United States)

    1997-01-01

    A two-year program was conducted to develop and commercially implement selected casting manufacturing technologies to enable significant reductions in the costs of castings, increase the complexity and dimensional accuracy of castings, and reduce the development times for delivery of high quality castings. The industry-led R&D project was cost shared with NASA's Aerospace Industry Technology Program (AITP). The Rocketdyne Division of Boeing North American, Inc. served as the team lead with participation from Lockheed Martin, Ford Motor Company, Howmet Corporation, PCC Airfoils, General Electric, UES, Inc., University of Alabama, Auburn University, Robinson, Inc., Aracor, and NASA-LeRC. The technical effort was organized into four distinct tasks. The accomplishments reported herein. Task 1.0 developed advanced simulation technology for core molding. Ford headed up this task. On this program, a specialized core machine was designed and built. Task 2.0 focused on intelligent process control for precision core molding. Howmet led this effort. The primary focus of these experimental efforts was to characterize the process parameters that have a strong impact on dimensional control issues of injection molded cores during their fabrication. Task 3.0 developed and applied rapid prototyping to produce near net shape castings. Rocketdyne was responsible for this task. CAD files were generated using reverse engineering, rapid prototype patterns were fabricated using SLS and SLA, and castings produced and evaluated. Task 4.0 was aimed at developing technology transfer. Rocketdyne coordinated this task. Casting related technology, explored and evaluated in the first three tasks of this program, was implemented into manufacturing processes.

  3. In-Orbit Performance Evaluation of a Spaceborne High Precision Fiber Optic Gyroscope.

    Science.gov (United States)

    Jin, Jing; Zhang, Ting; Kong, Linghai; Ma, Kun

    2018-01-01

    An in-orbit experiment was launched to evaluate the performance of the spaceborne high precision fiber optic gyroscopes (FOG). The three-axis in-orbit data of the FOG were analyzed using wavelet analysis method. Features of low frequency period terms and glitch noise were demonstrated. In addition, a method to extract the random noise from the in-orbit data is proposed based on the first-order difference method and the Pauta criterion. In addition, the random walk coefficient (RWC) of the FOG was calculated with the Allan variance method. Compared the ground test results, the in-orbit performance evaluation of Spaceborne High Precision Fiber Optic Gyroscope was verified.

  4. Role of low-energy observables in precision Higgs boson analyses

    Energy Technology Data Exchange (ETDEWEB)

    Petrov, Alexey A. [Wayne State Univ., Detroit, MI (United States); Univ. of Michigan, Ann Arbor, MI (United States); Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Pokorski, Stefan [Univ. of Warsaw, Warsaw (Poland); Wells, James D. [Univ. of Michigan, Ann Arbor, MI (United States); Zhang, Zhengkang [Univ. of Michigan, Ann Arbor, MI (United States)

    2015-04-02

    A conventional approach to precision calculations of Higgs boson observables uses quark masses mc and mb as inputs. However, quark masses are single numbers that hide a variety of low-energy data from which they are extracted, and also hide the various sources of theoretical uncertainties and correlations with additional input parameters such as αs. Higher-precision calculations, which are needed to give meaning to future measurements, require more direct engagement with the low-energy data in a global analysis. As a result, we present an initial calculation in this direction, which illustrates the procedure and reveals some of the theory uncertainties that challenge subpercent determinations of Higgs boson partial widths.

  5. Roadmap to a Comprehensive Clinical Data Warehouse for Precision Medicine Applications in Oncology.

    Science.gov (United States)

    Foran, David J; Chen, Wenjin; Chu, Huiqi; Sadimin, Evita; Loh, Doreen; Riedlinger, Gregory; Goodell, Lauri A; Ganesan, Shridar; Hirshfield, Kim; Rodriguez, Lorna; DiPaola, Robert S

    2017-01-01

    Leading institutions throughout the country have established Precision Medicine programs to support personalized treatment of patients. A cornerstone for these programs is the establishment of enterprise-wide Clinical Data Warehouses. Working shoulder-to-shoulder, a team of physicians, systems biologists, engineers, and scientists at Rutgers Cancer Institute of New Jersey have designed, developed, and implemented the Warehouse with information originating from data sources, including Electronic Medical Records, Clinical Trial Management Systems, Tumor Registries, Biospecimen Repositories, Radiology and Pathology archives, and Next Generation Sequencing services. Innovative solutions were implemented to detect and extract unstructured clinical information that was embedded in paper/text documents, including synoptic pathology reports. Supporting important precision medicine use cases, the growing Warehouse enables physicians to systematically mine and review the molecular, genomic, image-based, and correlated clinical information of patient tumors individually or as part of large cohorts to identify changes and patterns that may influence treatment decisions and potential outcomes.

  6. Roadmap to a Comprehensive Clinical Data Warehouse for Precision Medicine Applications in Oncology

    Science.gov (United States)

    Foran, David J; Chen, Wenjin; Chu, Huiqi; Sadimin, Evita; Loh, Doreen; Riedlinger, Gregory; Goodell, Lauri A; Ganesan, Shridar; Hirshfield, Kim; Rodriguez, Lorna; DiPaola, Robert S

    2017-01-01

    Leading institutions throughout the country have established Precision Medicine programs to support personalized treatment of patients. A cornerstone for these programs is the establishment of enterprise-wide Clinical Data Warehouses. Working shoulder-to-shoulder, a team of physicians, systems biologists, engineers, and scientists at Rutgers Cancer Institute of New Jersey have designed, developed, and implemented the Warehouse with information originating from data sources, including Electronic Medical Records, Clinical Trial Management Systems, Tumor Registries, Biospecimen Repositories, Radiology and Pathology archives, and Next Generation Sequencing services. Innovative solutions were implemented to detect and extract unstructured clinical information that was embedded in paper/text documents, including synoptic pathology reports. Supporting important precision medicine use cases, the growing Warehouse enables physicians to systematically mine and review the molecular, genomic, image-based, and correlated clinical information of patient tumors individually or as part of large cohorts to identify changes and patterns that may influence treatment decisions and potential outcomes. PMID:28469389

  7. A hand-held 3D laser scanning with global positioning system of subvoxel precision

    Energy Technology Data Exchange (ETDEWEB)

    Arias, Nestor [GOM, Departamento de Fisica y Geologia, Universidad de Pamplona (Colombia); Meneses, Nestor; Meneses, Jaime [GOTS-CENM, Escuela de Fisica, UIS, Bucaramanga (Colombia); Gharbi, Tijani, E-mail: nesariher@unipamplona.edu.co [Departement D' Optique, FEMTO-ST, 16 Route de Gray, 25030 Besancon (France)

    2011-01-01

    In this paper we propose a hand-held 3D laser scanner composed of an optical head device to extract 3D local surface information and a stereo vision system with subvoxel precision to measure the position and orientation of the 3D optical head. The optical head is manually scanned over the surface object by the operator. The orientation and position of the 3D optical head is determined by a phase-sensitive method using a 2D regular intensity pattern. This phase reference pattern is rigidly fixed to the optical head and allows their 3D location with subvoxel precision in the observation field of the stereo vision system. The 3D resolution achieved by the stereo vision system is about 33 microns at 1.8 m with an observation field of 60cm x 60cm.

  8. Exhaustive extraction of peptides by electromembrane extraction

    DEFF Research Database (Denmark)

    Huang, Chuixiu; Gjelstad, Astrid; Pedersen-Bjergaard, Stig

    2015-01-01

    This fundamental work illustrates for the first time the possibility of exhaustive extraction of peptides using electromembrane extraction (EME) under low system-current conditions (... 15% (v/v) DEHP was selected as a suitable SLM for exhaustive extraction of peptides under low system-current conditions. Interestingly, increasing the SLM volume from 5 to 10 μL was found to be beneficial for stable and efficient EME. The pH of the sample strongly affected the EME process, and pH 3.......5 was found to be optimal. The EME efficiency was also dependent on the acceptor solution composition, and the extraction time was found to be an important element for exhaustive extraction. When EME was carried out for 25 min with an extraction voltage of 15 V, the system-current across the SLM was less than...

  9. [Precise thoracic surgery: new era of minimally invasive surgery].

    Science.gov (United States)

    Li, Hui

    2015-10-01

    Precise surgery is based on the integrated application of modern science and technology and integrated innovation of surgical technology revolution features. It is built in high-end digital medical bases. The purpose of precise surgery is to achieve accurate lesion resection, minimize injury, improve the quality of life and reduce the risk of surgery. In this paper we forward new concept of precise thoracic surgery. An overview was made on the development of precise surgery with great support of virtual reality technology, augmented reality technology and image acquisition technology. Finally the paper illustrated the prospect of precise of thoracic surgery from the following aspects: preoperative planning, the choice of surgical approach, precise tumor localization, postoperative immediate 3-dimension multi modality imaging evaluation.

  10. Precision displacement measurement using a modulating ESPI

    Science.gov (United States)

    Kim, Seong Jong; Kang, Young June; Hong, Dong Pyo; Kim, Kyung Suk; Park, Nak Kyu; Ryu, Weon Jae; Choi, Man Young

    2007-10-01

    Laser interferometry is widely used as a measuring system in many fields because of its high resolution and ability to measure a broad area in real-time all at once. In conventional LASER interferometry, for example Out-of-plane ESPI(Electronic Speckle Pattern Interferometry), In plane ESPI, Shearography and Holography, it uses PZT or other components as a phase shift instrumentation to extract 3D deformation data, vibration mode and others. However, in most cases PZT has some disadvantages, which include non-linear errors and limited time of use. In the present study, a new type of LASER interferometry using a laser diode is proposed. Using LASER Diode Sinusoidal Phase Modulating (LD-SPM) interferometry, the phase modulation can directly modulated by controlling the LASER Diode injection current thereby eliminating the need for PZT and its components. This makes the interferometry more compact. This paper reports on a new approach to the LD Modulating interferometry that involves four-bucket phase shift method. This study proposes a four-bucket phase mapping algorithm, which developed to have a guaranteed application, to stabilize the system in the field and to be a user-friendly GUI. In this paper, LD modulating interferometry had shown the theory for LD wavelength modulation and sinusoidal phase modulation. Four-bucket phase mapping algorithm then introduced.

  11. Automatic Definition Extraction and Crossword Generation From Spanish News Text

    Directory of Open Access Journals (Sweden)

    Jennifer Esteche

    2017-08-01

    Full Text Available This paper describes the design and implementation of a system that takes Spanish texts and generates crosswords (board and definitions in a fully automatic way using definitions extracted from those texts. Our solution divides the problem in two parts: a definition extraction module that applies pattern matching implemented in Python, and a crossword generation module that uses a greedy strategy implemented in Prolog. The system achieves 73% precision and builds crosswords similar to those built by humans.

  12. Precision Electroweak Measurements on the Z Presonance

    Energy Technology Data Exchange (ETDEWEB)

    Aleph,Delphi,L3,Opal,SLD , Collaborations

    2005-09-08

    The authors report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. the data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLD experiment using a polarized beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarized asymmetries. The mass and width of the Z boson, m{sub Z} and {Lambda}{sub Z}, and its couplings to fermions, for example the {rho} parameter and the effective electroweak mixing angle for leptons, are precisely measured: m{sub Z} = 91.1875 {+-} 0.0021 GeV; {Lambda}{sub Z} = 2.4952 {+-} 0.0023 GeV; {rho}{sub {ell}} = 1.0050 {+-} 0.0010; sin{sup 2} {theta}{sub eff}{sup lept} = 0.23153 {+-} 0.00016. The number of light neutrino species is determined to be 2.9840 {+-} 0.0082, in agreement with the three observed generations of fundamental fermions. The results are compared to the predictions of the Standard Model. At the Z-pole, electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its Standard Model expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the Z-pole data are also used to predict the mass of the top quark, m{sub t} = 173{sub -10}{sup +13} GeV, and the mass of the W boson, m{sub W} = 80.363 {+-} 0.032 GeV. These indirect constraints are compared to the direct measurements, providing a stringent test of the Standard Model. Using in addition the direct measurements of m{sub t} and m{sub W}, the mass of the as yet unobserved Standard Model Higgs boson is predicted with a

  13. Atomically Precise Metal Nanoclusters for Catalytic Application

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Rongchao [Carnegie Mellon Univ., Pittsburgh, PA (United States)

    2016-11-18

    The central goal of this project is to explore the catalytic application of atomically precise gold nanoclusters. By solving the total structures of ligand-protected nanoclusters, we aim to correlate the catalytic properties of metal nanoclusters with their atomic/electronic structures. Such correlation unravel some fundamental aspects of nanocatalysis, such as the nature of particle size effect, origin of catalytic selectivity, particle-support interactions, the identification of catalytically active centers, etc. The well-defined nanocluster catalysts mediate the knowledge gap between single crystal model catalysts and real-world conventional nanocatalysts. These nanoclusters also hold great promise in catalyzing certain types of reactions with extraordinarily high selectivity. These aims are in line with the overall goals of the catalytic science and technology of DOE and advance the BES mission “to support fundamental research to understand, predict, and ultimately control matter and energy at the level of electrons, atoms, and molecules”. Our group has successfully prepared different sized, robust gold nanoclusters protected by thiolates, such as Au25(SR)18, Au28(SR)20, Au38(SR)24, Au99(SR)42, Au144(SR)60, etc. Some of these nanoclusters have been crystallographically characterized through X-ray crystallography. These ultrasmall nanoclusters (< 2 nm diameter) exhibit discrete electronic structures due to quantum size effect, as opposed to quasicontinuous band structure of conventional metal nanoparticles or bulk metals. The available atomic structures (metal core plus surface ligands) of nanoclusters serve as the basis for structure-property correlations. We have investigated the unique catalytic properties of nanoclusters (i.e. not observed in conventional nanogold catalysts) and revealed the structure-selectivity relationships. Highlights of our

  14. Threshold Corrections in Precision LHC Physics: QED otimes QCD

    CERN Document Server

    Ward, B F L; Jadach, Stanislaw; Yost, S A

    2004-01-01

    With an eye toward LHC processes in which theoretical precisions of 1 percent are desired, we introduce the theory of the simultaneous YFS resummation of QED and QCD to compute the size of the expected resummed soft radiative threshold effects in precision studies of heavy particle production at the LHC. Our results show that both QED and QCD soft threshold effects must be controlled to be on the conservative side to achieve such precision goals.

  15. precision deburring using NC and robot equipment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Gillespie, L.K.

    1980-05-01

    Deburring precision miniature components is often time consuming and inconsistent. Although robots are available for deburring parts, they are not precise enough for precision miniature parts. Numerical control (NC) machining can provide edge break consistencies to meet requirements such as 76.2-..mu..m maximum edge break (chamfer). Although NC machining has a number of technical limitations which prohibits its use on many geometries, it can be an effective approach to features that are particularly difficult to deburr.

  16. Phytochemical Screening and Acute Toxicity of Aqueous Extract of Leaves of Conocarpus erectus Linnaeus in Swiss Albino Mice

    Directory of Open Access Journals (Sweden)

    DAYANE K.D. NASCIMENTO

    2016-01-01

    Full Text Available ABSTRACT Mangroves represent areas of high biological productivity and it is a region rich in bioactive substances used in medicine production. Conocarpus erectus (Combretaceae known as button mangrove is one of the species found in mangroves and it is used in folk medicine in the treatment of anemia, catarrh, conjunctivitis, diabetes, diarrhea, fever, gonorrhea, headache, hemorrhage, orchitis, rash, bumps and syphilis. The present study aimed to investigate the acute toxicity of aqueous extract of leaves of C. erectus in Swiss albino mice. The plant material was collected in Vila Velha mangroves, located in Itamaracá (PE. The material was subjected to a phytochemical screening where extractive protocols to identify majority molecules present in leaves were used. The evaluation of acute toxicity of aqueous extract of C. erectus followed the model of Acute Toxicity Class based on OECD 423 Guideline, 2001. The majority molecules were identified: flavonoids, tannins and saponins. The LD50 was estimated at 2,000 mg/kg bw. Therefore, the aqueous extract showed low acute toxicity classified in category 5.

  17. Precision jet measurements at HERA and determination of \\alpha_s

    CERN Document Server

    Kogler, Roman

    2011-01-01

    The status is reviewed of recent high precision measurements of inclusive-jet, dijet and trijet production in deep-inelastic scattering and photoproduction by the HERA experiments H1 and ZEUS. The measurements are in good agreement with perturbative QCD calculations at next-to-leading order and are used for the extraction of the value of the strong coupling at the mass of the Z boson, \\alpha_s(M_Z). The methods and results of the QCD analyses are presented and a summary of the values of \\alpha_s(M_Z) from recent jet measurements at HERA is given.

  18. Precise measurement of local strain fields with energy-unfiltered convergent-beam electron diffraction.

    Science.gov (United States)

    Yamazaki, Takashi; Isaka, Tomoko; Kuramochi, Koji; Hashimoto, Iwao; Watanabe, Kazuto

    2006-05-01

    A simple and robust method to precisely determine local strain fields using energy-unfiltered convergent-beam electron diffraction is presented. This method involves the subtraction of background intensity, the extraction of higher-order Laue-zone lines by tracing using a Radon transformation and a system of analytical strain determination without the need for an optimization routine such as chi2-based minimization. As an example, the measurement of residual strain in a silicon-on-insulator wafer is demonstrated. It is found from micro-Raman spectroscopy analysis that, at the nanometre scale, this measurement succeeds with an accuracy of 0.06%.

  19. Application of length vernier in phase coincidence detection and precision frequency measurement.

    Science.gov (United States)

    Miao, Miao; Wei, Zhou; Bin, Wang

    2012-02-01

    For comparison of arbitrary frequency signals, the paper proposed two levels of length vernier based on the time-space relationship are used in three levels of phase coincidence detecting circuits to extract the phase coincidence information by proper logic calculation. The length∕phase of each vernier is respectively corresponding to the accuracy and the resolution of detecting circuit. The time-space relationship is based on high-stability, high-accuracy, and high-speed of signal transmission. The method is effective to reduce the fuzzy region in the phase coincidence information and reach a higher measuring precision.

  20. Fluxgate magnetometry for precise mapping of the Earth's field

    DEFF Research Database (Denmark)

    Primdahl, Fritz; Merayo, José M.G.; Brauer, Peter

    2007-01-01

    The requirements for precise global mapping of the Earth's vector magnetic field from a high inclination LEO satellite needs a stable and precise vector magnetometer. Equally important are the measurement of the stellar attitude of the vector sensor and establishment of the calibration by onboard...... comparison to an absolute scalar magnetometer. In addition, the position in orbit and the precise timing relative to the UTC is needed. Finally, the end-to-end system precision also depends on a known and controlled local satellite magnetic field....