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Sample records for bttner dirk ebling

  1. Dirk Ligter as versetfiguur

    Directory of Open Access Journals (Sweden)

    G. Meintjes

    1991-05-01

    Full Text Available The Dirk Ligter texts in the oeuvre of Boerneef form a transtextual unit as a result of which a Dirk Ligter code is generated and consequently the Dirk Ligter texts become increasingly more duplicitous when read in the transtextual context of the volume Boplaas as a whole. In this oeuvre the emphasis is not on "well-made" units but rather on the process of activating signs which gradually become part of a Boplaas code. This code becomes a sign of an ethos which, in turn, signifies an existential space. An analysis of the epical elements figure, space, lime and events reveals how Dirk Ligter is portrayed as a clown, an artist, and as man on earth. In addition to becoming a representative of the so-called coloured people of Boplaas, he is, first and foremost, presented in the text as a resistance figure.

  2. Dirk Bakker 1947 – 2009

    CERN Document Server

    2009-01-01

    Dirk Bakker, far left, with his colleagues in the former AB-CO group during a test of new prototype consoles for the CERN Control Centre in 2005.It was with great sorrow that we learnt of the death of our colleague Dirk, taken too quickly by an incurable illness against which he fought with courage and dignity. Dirk arrived at CERN on 16 April, 1972 and spent nearly 36 years in the accelerator sector. He was instrumental in the distribution of the audio and video signals between the various accelerators and the control rooms and for the deployment of TV transmissions on the many screens all over the site. He was also the key person organizing the installations in the control rooms and his recent contributions for the CERN Control Centre (CCC) were exemplary. All the users of his services knew Dirk as an indispensable expert whose knowledge and professionalism were always appreciated. His discretion and pride in his work made Dirk a ...

  3. Interview with professor Dirk Geeraerts

    OpenAIRE

    Wiedemer, Marcos Luiz; UERJ-FFP; Rosário, Ivo da Costa do; UFF

    2015-01-01

    Dirk Geeraerts is professor of linguistics at the University of Leuven, Belgium, and his main research interests involve the fields of lexical semantics, lexicology, and lexicography, with a focus on social variation and diachronic change. His theoretical orientation is mainly that of Cognitive Linguistics, with an emphasis on empirical methods for linguistic analysis. He is the founder of the journal Cognitive Linguistics and he is the editor, with Hubert Cuyckens, of The Oxford Handbook of ...

  4. Universe opacity and EBL

    Science.gov (United States)

    Vavryčuk, Václav

    2017-02-01

    The observed extragalactic background light (EBL) is affected by light attenuation due to absorption of light by galactic and intergalactic dust in the Universe. Even galactic opacity of 10-20 per cent and minute universe intergalactic opacity of 0.01 mag h Gpc-1 at the local Universe have a significant impact on the EBL because obscuration of galaxies and density of intergalactic dust increase with redshift as (1 + z)3. Consequently, intergalactic opacity increases and the Universe becomes considerably opaque at z > 3. Adopting realistic values for galactic and intergalactic opacity, the estimates of the EBL for the expanding dusty universe are close to observations. The luminosity density evolution fits well measurements. The model reproduces a steep increase of the luminosity density at z EBL ranges from 100 to 200 nW m-2 sr-1 and is within the limits of 40 and 200 nW m-2 sr-1 of current EBL observations. The model predicts 98 per cent of the EBL coming from radiation of galaxies at z 3.5.

  5. Universe opacity and EBL

    CERN Document Server

    Vavrycuk, Vaclav

    2016-01-01

    The observed extragalactic background light (EBL) is affected by light attenuation due to absorption of light by galactic and intergalactic dust in the Universe. Even galactic opacity of 10-20 percent and minute universe intergalactic opacity of $0.01\\,\\mathrm{mag}\\,h\\,\\mathrm{Gpc}^{-1}$ at the local Universe have a significant impact on the EBL because obscuration of galaxies and density of intergalactic dust increase with redshift as $\\left(1+z\\right)^3$. Consequently, intergalactic opacity increases and the Universe becomes considerably opaque at $z > 3$. Adopting realistic values for galactic and intergalactic opacity, the estimates of the EBL for the expanding dusty universe are close to observations. The luminosity density evolution fits well measurements. The model reproduces a steep increase of the luminosity density at $z3.5$.

  6. First light at EBL2

    Science.gov (United States)

    Koster, Norbert; te Sligte, Edwin; Molkenboer, Freek; Deutz, Alex; van der Walle, Peter; Muilwijk, Pim; Mulckhuyse, Wouter; Oostdijck, Bastiaan; Hollemans, Christiaan; Nijland, Björn; Kerkhof, Peter; van Putten, Michel; Westerhout, Jeroen

    2017-03-01

    TNO is building EBL2 as a publicly accessible test facility for EUV lithography related development of photomasks, pellicles, optics, and other components requiring EUV exposure. EBL2 consists of a EUV Beam Line, a XPS system, and sample handling infrastructure. Recently we finished installation of the source, exposure chamber, handlers and XPS system. This paper describes the integration process and first light of the EUV source.EBL2 accepts a wide range of sample sizes, including EUV masks with or without pellicles. All types of samples will be loaded using a standard dual pod interface. EUV masks returned from EBL2 will retain their NXE compatibility to facilitate wafer printing on scanners after exposure in EBL2. The Beam Line provides high intensity EUV irradiation from a Sn-fueled EUV source from Ushio. EUV intensity, spectrum, and repetition rate are all adjustable. The XPS system is now operational and accepts samples up to reticle size.

  7. Pädevuskeskne õpe / Dirk van Vierssen

    Index Scriptorium Estoniae

    Vierssen, Dirk van

    2002-01-01

    Eestis korraldatakse politseikoolitust ümber. Konsultandiks on Hollandi Politseikoolituse Keskuse spetsialist, kasvatusteaduste doktor Dirk van Vierssen. Reformi sisu on üleminek kvalifikatsioonikeskselt õppelt pädevuskesksele (kompetentsusele põhinevale) õppele. Kvalifikatsioonikeskse ja pädevuskeskse õppe erinevusi / lindilt üles kirjutanud Raivo Juurak

  8. Essays in theoretical physics in honour of Dirk Ter Haar

    CERN Document Server

    Parry, W E

    2013-01-01

    Essays in Theoretical Physics: In Honour of Dirk ter Haar is devoted to Dirk ter Haar, detailing the breadth of Dirk's interest in physics. The book contains 15 chapters, with some chapters elucidating stellar dynamics with non-classical integrals; a mean-field treatment of charge density waves in a strong magnetic field; electrodynamics of two-dimensional (surface) superconductors; and the Bethe Ansatz and exact solutions of the Kondo and related magnetic impurity models. Other chapters focus on probing the interiors of neutron stars; macroscopic quantum tunneling; unitary transformation meth

  9. Decreasing the cutoff for elevated blood lead (EBL) can decrease the screening sensitivity for EBL.

    Science.gov (United States)

    McCloskey, Laura J; Bordash, Frank R; Ubben, Kathy J; Landmark, James D; Stickle, Douglas F

    2013-03-01

    Change in the definition of elevated blood lead (EBL) from greater than or equal to 10 μg/dL (cutoff A) to greater than or equal to 5 μg/dL (cutoff B) was recently endorsed in the United States. A potential effect of this change is to decrease the screening sensitivity for EBL detection. We demonstrate this effect by simulated sampling of an example patient distribution for lead. Using lead-dependent assay imprecision, simulated sampling of the patient distribution tracked individual misclassifications relative to the EBL cutoff. Decreasing the EBL cutoff from A to B reduced screening sensitivity for EBL detection in this population to less than 90%, a decrease of 4%. The result was due to the fact that, for B, a greater fraction of the EBL population was near the EBL cutoff and therefore subject to misclassification due to assay imprecision. The effect of the decreased EBL cutoff to reduce EBL screening sensitivity is likely to apply to EBL screening programs generally.

  10. Jodi / Dirk Paesmans ; interv. Tilman Baumgärtel

    Index Scriptorium Estoniae

    Paesmans, Dirk

    2006-01-01

    1994. aastast nime Jodi all töötavast kunstnikepaarist, kelle moodustavad Barcelonas elavad Dirk Paesmans ja Joan Heemskerk. 1999. a. omistati Jodile Webby auhind kunsti kategoorias. D. Paesmans 2001. a. tehtud telefoniintervjuus töödest "OSS****", "SOD", versioonidest arvutimängudele "Quake" ja "Wolfenstein", "Valebrauseritest", huvist kunstilise tarkvara loomise ja eksisteerivate programmide modifitseerimise vastu

  11. Jodi / Dirk Paesmans ; interv. Tilman Baumgärtel

    Index Scriptorium Estoniae

    Paesmans, Dirk

    2006-01-01

    1994. aastast nime Jodi all töötavast kunstnikepaarist, kelle moodustavad Barcelonas elavad Dirk Paesmans ja Joan Heemskerk. 1999. a. omistati Jodile Webby auhind kunsti kategoorias. D. Paesmans 2001. a. tehtud telefoniintervjuus töödest "OSS****", "SOD", versioonidest arvutimängudele "Quake" ja "Wolfenstein", "Valebrauseritest", huvist kunstilise tarkvara loomise ja eksisteerivate programmide modifitseerimise vastu

  12. The Current State of EBL (Editorial

    Directory of Open Access Journals (Sweden)

    Lindsay Glynn

    2006-06-01

    Full Text Available Evidence based librarianship, still in its infancy, is slowly gaining interest and momentum. Increased exposure to the evidence based model of practice is allowing information specialists to learn more about what is involved and how its application can affect practice. Events such as the International Conference on Evidence Based Library and Information Practice and publications such as EBLIP help to increase awareness of EBL as well as increase the body of evidence necessary to fully implement such a practice model. Having said that, barriers remain that hinder the application of evidence based librarianship in its most basic form. Brice, Booth and Bexon established six steps involved in the practice of EBL: specify the problem, find evidence to answer the problem, appraise the evidence, apply the results, evaluate the outcome, and redefine the problem. Without a large body of research from which to draw evidence, information professionals are often forced to replace the step of finding the evidence with designing and performing their own research. What this means is that rather than being able to find, appraise, and implement existing research, practitioners are finding themselves in a position where they have to design and carry out original research in order to obtain applicable evidence. Aside from being time consuming and costly, many are not comfortable with research design or data analysis, and they may lack administrative support or the needed resources available to support research. Until the body of evidence is substantially increased, it is essential that original research be encouraged and published. I recently posted a message to the EBLIG electronic mail list requesting EBL success stories. I hoped to hear how people had used evidence to assist in their decision making as well as whether the applied evidence had a positive or negative result once implemented. The response was minimal, save for three people who had carried out

  13. Evidence-based librarianship: searching for the needed EBL evidence.

    Science.gov (United States)

    Eldredge, J D

    2000-01-01

    This paper discusses the challenges of finding evidence needed to implement Evidence-Based Librarianship (EBL). Focusing first on database coverage for three health sciences librarianship journals, the article examines the information contents of different databases. Strategies are needed to search for relevant evidence in the library literature via these databases, and the problems associated with searching the grey literature of librarianship. Database coverage, plausible search strategies, and the grey literature of library science all pose challenges to finding the needed research evidence for practicing EBL. Health sciences librarians need to ensure that systems are designed that can track and provide access to needed research evidence to support Evidence-Based Librarianship (EBL).

  14. Impact of galactic and intergalactic dust on the stellar EBL

    Science.gov (United States)

    Vavryčuk, V.

    2016-06-01

    Current theories assume that the low intensity of the stellar extragalactic background light (stellar EBL) is caused by finite age of the Universe because the finite-age factor limits the number of photons that have been pumped into the space by galaxies and thus the sky is dark in the night. We oppose this opinion and show that two main factors are responsible for the extremely low intensity of the observed stellar EBL. The first factor is a low mean surface brightness of galaxies, which causes a low luminosity density in the local Universe. The second factor is light extinction due to absorption by galactic and intergalactic dust. Dust produces a partial opacity of galaxies and of the Universe. The galactic opacity reduces the intensity of light from more distant background galaxies obscured by foreground galaxies. The inclination-averaged values of the effective extinction AV for light passing through a galaxy is about 0.2 mag. This causes that distant background galaxies become apparently faint and do not contribute to the EBL significantly. In addition, light of distant galaxies is dimmed due to absorption by intergalactic dust. Even a minute intergalactic opacity of 1 × 10^{-2} mag per Gpc is high enough to produce significant effects on the EBL. As a consequence, the EBL is comparable with or lower than the mean surface brightness of galaxies. Comparing both extinction effects, the impact of the intergalactic opacity on the EBL is more significant than the obscuration of distant galaxies by partially opaque foreground galaxies by factor of 10 or more. The absorbed starlight heats up the galactic and intergalactic dust and is further re-radiated at IR, FIR and micro-wave spectrum. Assuming static infinite universe with no galactic or intergalactic dust, the stellar EBL should be as high as the surface brightness of stars. However, if dust is considered, the predicted stellar EBL is about 290 nW m^{-2} sr^{-1}, which is only 5 times higher than the observed

  15. 75 FR 61466 - Dirk Wiggins; Notice of Declaration of Intention and Soliciting Comments, Protests, and/or...

    Science.gov (United States)

    2010-10-05

    ... Energy Regulatory Commission Dirk Wiggins; Notice of Declaration of Intention and Soliciting Comments... Wiggins. e. Name of Project: BC Creek Hydro Project. f. Location: The proposed BC Creek Hydro Project will...: Section 23(b)(1) of the Federal Power Act, 16 U.S.C. 817(b). h. Applicant Contact: Dirk Wiggins,...

  16. EBL constraints with VERITAS gamma-ray observations

    Science.gov (United States)

    Fernandez Alonso, M.; VERITAS Collaboration

    2017-10-01

    The extragalactic background light (EBL) contains all the radiation emitted by nuclear and accretion processes since the epoch of recombination. Direct measurements of the EBL in the near-IR to mid-IR waveband are extremely difficult due mainly to the zodiacal light foreground. Instead, gamma-ray astronomy offers the possibility to indirectly set limits to the EBL by studying the effects of gamma-ray absorption in the spectra of detected sources in the very high energy range (VHE: 100 GeV). These effects can be generally seen in the spectra of VHE blazars as a softening (steepening) of the spectrum and/or abrupt changes in the spectral index or breaks. In this work, we use recent VERITAS data of a group of blazars and apply two methods to derive constraints for the EBL spectral properties. We present preliminary results that will be completed with new observations in the near future to enhance the calculated restrictions to the EBL.

  17. The design and implementation of the DIRK system for dosemeter issue and record keeping

    CERN Document Server

    Kendall, G M; Kay, P; Law, D V; Salmon, L; Saw, G M A

    1983-01-01

    DIRK, the computerised system which the National Radiological Protection Board employs for its Personal Monitoring Service, is described. DIRK is also used to store the data for the National Registry for Radiation Workers and could support the Central Index of Dose Information should this be set up. The general principles of the design of DIRK, as well as a detailed description of the system, are included in the report. DIRK is based on a set of interlocked index sequential files manipulated by PL/1 programs. Data compaction techniques are used to reduce by a factor of ten the size of the files stored on magnetic disk. Security of the database is most important and two levels of security have been implemented. Table driven techniques are used for updating the database. A specially designed free-format language is used for specifying changes. Statistics, sorted listings of selected data and summaries are provided by a general purpose program for this type of operation. However, it has still been necessary to w...

  18. Enhancing Students' Potential: EBL Projects in Language Teaching

    Science.gov (United States)

    Federici, Theresa

    2017-01-01

    This paper outlines the rationale behind L2 process writing and Enquiry-Based Learning (EBL) approaches adopted in order to design a course within a modern language degree to bridge the gap between language and culture elements of the programme. This was achieved by creating an environment that replicates that of a researcher and by placing…

  19. EBL Inhomogeneity and Hard-Spectrum Gamma-Ray Sources

    Science.gov (United States)

    Abdalla, Hassan; Böttcher, Markus

    2017-02-01

    The unexpectedly hard very-high-energy (VHE; E > 100 GeV) γ-ray spectra of a few distant blazars have been interpreted as evidence of a reduction of the γγ opacity of the universe due to the interaction of VHE γ-rays with the extragalactic background light (EBL) compared to the expectation from current knowledge of the density and cosmological evolution of the EBL. One of the suggested solutions to this problem involves the inhomogeneity of the EBL. In this paper, we study the effects of such inhomogeneity on the energy density of the EBL (which then also becomes anisotropic) and the resulting γγ opacity. Specifically, we investigate the effects of cosmic voids along the line of sight to a distant blazar. We find that the effect of such voids on the γγ opacity, for any realistic void size, is only of the order of ≲1% and much smaller than expected from a simple linear scaling of the γγ opacity with the line-of-sight galaxy underdensity due to a cosmic void.

  20. EBL2, a flexible, controlled EUV exposure and surface analysis facility

    NARCIS (Netherlands)

    Sligte, E. te; Koster, N.B.; Molkenboer, F.T.; Deutz, A.F.

    2016-01-01

    TNO is building EBL2 as a publicly accessible test facility for EUV lithography related development of photomasks, pellicles, optics, and other components. EBL2 will consist of a Beam Line, an XPS system, and sample handling infrastructure. EBL2 will accept a wide range of sample sizes, including EU

  1. Ds Dirk van der Hoff se bydrae tot die ontwikkeling van die Christelik-nasionale onderwysstelsel in die ZAR

    Directory of Open Access Journals (Sweden)

    E. Oliver

    1992-01-01

    Full Text Available Reverend Dirk van der Hoff's contribution to the development of Christian National Education in the Zuid-Afrikaansche Republiek Today, Afrikaners are closely associated with the Christian National system of education. This system has a long and interesting history and many people have been involved in its development. This article shows the vital and essential role that Reverend Dirk van der Hoff, the first resident minister of religion in the ZAR, played in the structuring of CNE.

  2. Robert Dirks, Food in the Gilded Age; What Ordinary Americans Ate

    Directory of Open Access Journals (Sweden)

    Scott Alan CARSON

    2016-09-01

    Full Text Available Abstract. Robert Dirks offers an important contribution to food and nutrition history in his book Food in the Gilded Age: What Ordinary Americans Ate. The book spans a broad swath of late 19th century US nutrition history using available dietaries from diverse sources and multiple ethnic groups. Early Mexican-Americans represent one of the earliest ethnic groups in the US. During the Gilded Age, the children of Native-Mexicans with early white European explorers –Mestizos-reflectthe most pre-developed diets in the West. Dirks summarizes their diets using Mexican-American households in Las Cruces, New Mexico and the Rio Grande Valley, Texas that were transitioning into Southwestern economies.Keywords. Food policy, Economic hitory, Americans ate.JEL. B10, L66, Q18.

  3. Impact of galactic and intergalactic dust on the stellar EBL

    CERN Document Server

    Vavrycuk, Vaclav

    2016-01-01

    Current theories assume that the low intensity of the stellar extragalactic background light (stellar EBL) is caused primarily by finite age of the Universe because the finite age limits the number of photons pumped into the space by galaxies and thus the sky is dark in the night. We oppose this opinion and show that two main factors are responsible for the extremely low intensity of the observed stellar EBL: (1) a low mean surface brightness of galaxies, which causes a low luminosity density in the local Universe, and (2) light extinction due to absorption by galactic and intergalactic dust. Dust produces a partial opacity of galaxies and of the Universe. The galactic opacity reduces the intensity of light from more distant background galaxies obscured by foreground galaxies. The effective extinction AV for light passing through a galaxy is 0.2 mag. This causes that distant background galaxies do not contribute to the EBL significantly. In addition, light of distant galaxies is dimmed due to absorption by in...

  4. Detecting the EBL attenuation of blazars with GLAST

    Science.gov (United States)

    Reyes, Luis C.

    The Large Area Telescope (LAT) on board GLAST (Gamma-ray Large Area Space Telescope) due for launch in late 2007 will study the gamma-ray sky in the energy range 20 MeV to >300 GeV. GLAST-LAT's improved sensitivity with respect to previous missions will increase the number of known gamma-ray blazars from about 100 to thousands, with redshifts up to z~3-5. Since g-rays with energy above 10 GeV interact via pair-production with photons from the Extragalactic Background Light (EBL), the systematic attenuation of GLAST-detected blazars as a function of redshift would constitute and effective and unique probe of the optical-UV EBL density and its evolution over cosmic history. Analysis techniques introduced in this dissertation make use of the large number of blazars detected by GLAST to study the collective behavior of their spectra as a function of redshift. These techniques are shown to offer powerful ways to help separate the common level of attenuation due to the EBL from the intrinsic peculiarities of individual blazars. The capability of GLAST to perform these measurements depends in great measure on the acceptance of the instrument to high energy g-rays ( E > 10 GeV), which in previous space-experiments has been drastically reduced due to backsplash self-veto. This dissertation includes a study of the backsplash effect as measured with flight-like detectors during a beam test of the LAT calibration unit. This analysis was used to verify the capabilities of the GLAST simulations tools to reproduce backsplash effects.

  5. Detecting a unique EBL signature with TeV gamma rays

    OpenAIRE

    Imran, Asif; Krennrich, Frank

    2007-01-01

    We discuss prospects for detecting a spectral break in gamma-ray spectra of blazars due to the extragalactic background light (EBL) density falling off between the near and mid-IR. A measurable spectral change in the TeV spectra at 1 TeV could arise from a rapid or slow drop in the EBL density above ~1 micron. This effect is mediated by the ratio of the near to mid-IR density of EBL. A detection of such a spectral feature could become a clear signature of EBL absorption. A non-detection would...

  6. Enodoscopic band ligation (EBL) is superior to endoscopic clipping for the treatment of colonic diverticular hemorrhage.

    Science.gov (United States)

    Setoyama, Takeshi; Ishii, Naoki; Fujita, Yoshiyuki

    2011-11-01

    Recently, endoscopic band ligation (EBL) has been used to treat colonic diverticular hemorrhage, but the number of EBL cases treated to date has been limited. This study aimed to evaluate the clinical outcomes of EBL in the treatment of colonic diverticular hemorrhage compared with those of endoclips. At St. Luke's International Hospital in Tokyo, 66 patients were treated with EBL or endoclips from January 2004 to October 2010. Early rebleeding was defined as clinical evidence of recurrent bleeding within 30 days after initial treatment. Patients' demographics, rate of early rebleeding, and complications were retrospectively evaluated. Of the 66 patients, 18 were treated with EBL. The initial success rate for hemostasis with EBL was 100% with no complications. Early rebleeding was observed in one patient (6%), for whom eversion of a bleeding diverticulum in the sigmoid colon could not be obtained and early loss of the O-band occurred. However, the patient could be retreated with EBL. On the other hand, complete eversion could be obtained for all 10 patients with right-sided diverticula, and no early rebleeding occurred. Endoclips were used to treat 48 patients. Although the initial success rate for hemostasis was 100% without any complications, the rate of early rebleeding was 33% (16 patients), which was significantly higher than the rate for the EBL-treated group (P = 0.018). According to the findings, EBL should be considered safe, effective, and superior to endoclips for the treatment of colonic diverticular hemorrhage. The EBL procedure should be attempted as the initial therapy especially for the right-sided disease.

  7. 75 FR 63169 - Dirk Wiggins; Notice of Petition for Declaratory Order and Soliciting Comments, Protests, and/or...

    Science.gov (United States)

    2010-10-14

    ... States; (3) would utilize surplus water or water power from a government dam; or (4) if applicable, has...: Dirk Wiggins. e. Name of Project: Duane Wiggins Hydro Project. f. Location: The existing Duane Higgins....gov using the ``eLibrary'' link. Enter the docket number excluding the last three digits in the docket...

  8. Hacia la observación de una sociedad venidera: Una entrevista con Dirk Baecker

    Directory of Open Access Journals (Sweden)

    Felipe Pérez-Solari

    2013-01-01

    Full Text Available Dirk Baecker ha sido reconocido como uno de los más connotados sociólogos alemanes con importantes trabajos en teoría de la cultura, teoría sociológica, sociología económica y sociología de las organizaciones, entre muchos otros. La siguiente entrevista inédita recorre diversos temas que han sido motivo de interés del sociólogo alemán como la teoría de sistemas sociales, los nuevos avances de la teoría sociológica, la sociedad mundial y sus importantes trabajos sobre lo que él ha llamado la ‘sociedad venidera'.

  9. Correction of placement error in EBL using model based method

    Science.gov (United States)

    Babin, Sergey; Borisov, Sergey; Militsin, Vladimir; Komagata, Tadashi; Wakatsuki, Tetsuro

    2016-10-01

    The main source of placement error in maskmaking using electron beam is charging. DISPLACE software provides a method to correct placement errors for any layout, based on a physical model. The charge of a photomask and multiple discharge mechanisms are simulated to find the charge distribution over the mask. The beam deflection is calculated for each location on the mask, creating data for the placement correction. The software considers the mask layout, EBL system setup, resist, and writing order, as well as other factors such as fogging and proximity effects correction. The output of the software is the data for placement correction. Unknown physical parameters such as fogging can be found from calibration experiments. A test layout on a single calibration mask was used to calibrate physical parameters used in the correction model. The extracted model parameters were used to verify the correction. As an ultimate test for the correction, a sophisticated layout was used for verification that was very different from the calibration mask. The placement correction results were predicted by DISPLACE, and the mask was fabricated and measured. A good correlation of the measured and predicted values of the correction all over the mask with the complex pattern confirmed the high accuracy of the charging placement error correction.

  10. EBL2, a flexible, controlled EUV exposure and surface analysis facility

    Science.gov (United States)

    te Sligte, Edwin; Koster, Norbert; Molkenboer, Freek; Deutz, Alex

    2016-05-01

    TNO is building EBL2 as a publicly accessible test facility for EUV lithography related development of photomasks, pellicles, optics, and other components. EBL2 will consist of a Beam Line, an XPS system, and sample handling infrastructure. EBL2 will accept a wide range of sample sizes, including EUV masks with or without pellicles. All types of samples will be loaded using a standard dual pod interface. EUV masks returned from EBL2 will retain their NXE compatibility. The Beam Line provides high intensity EUV irradiation from a Sn-fueled EUV source. EUV intensity, pupil, spectrum, and repetition rate are all adjustable. In-situ measurements by ellipsometry will enable real time monitoring of the sample condition. The XPS will be capable of analyzing the full surface area of EUV masks and pellicles, as well as performing angle resolved analysis on smaller samples. Sample transfer between the XPS and the Beam Line will be possible without breaking vacuum.

  11. Probing the EBL evolution at high redshifts using 22 GRBs detected with the Fermi-LAT

    Science.gov (United States)

    Amitbhai Desai, Abhishek; Ajello, Marco; Omodei, Nicola; Hartmann, Dieter; Fermi-LAT Collaboration

    2017-01-01

    The extragalactic background light (EBL) is the collective emission of all the stars and galaxies over the history of the universe. The most efficient method to study the EBL is through the imprint it leaves via photon-photon annihilation in the spectra of distant gamma-ray sources. Here we present a combined analysis of a sample of 22 Gamma Ray Bursts (GRBs) detected by Fermi Large Area Telescope. GRBs are short-lived, bright, high-energy sources detected up to very high redshifts. This allows us to probe the EBL at much higher redshifts than before. We report the first constrain on the EBL when the Universe was one fourth of its present age (z=1.8). This will be discussed in the context of the generation of the UV-optical background and the star-formation activity of the Universe.

  12. Plasmodium falciparum MAEBL is a unique member of the ebl family.

    Science.gov (United States)

    Blair, Peter L; Kappe, Stefan H I; Maciel, Jorge E; Balu, Bharath; Adams, John H

    2002-06-01

    Malaria is one of the deadliest human diseases and efforts to control it have been difficult due to the protozoan parasites' complex biology. Malaria merozoite invasion of erythrocytes is an essential part of blood-stage infections. The invasion process is mediated by numerous parasite molecules, such as EBA-175, a member of the ebl family of erythrocyte binding proteins. We have identified maebl, an ebl paralogue, in Plasmodium falciparum and found it highly conserved with its orthologues in P. yoelii and P. berghei, but distinct from other Plasmodium ebl. Importantly, the putative MAEBL ligand domains are highly conserved and are similar to AMA-1, but not the consensus DBL ligand domains present in all other ebl. In mature merozoites, MAEBL localized with rhoptry proteins (RhopH2, RAP-1), including surface localization with RhopH2, but not microneme proteins (EBA-175, BAEBL). MAEBL appears as proteolytically processed fragments in P. falciparum parasites. The amino cysteine-rich ligand domains were present primarily in culture supernatants, while the carboxyl cysteine-rich domain adjacent to the transmembrane domain was preferentially isolated from Triton X-100 extracted fractions. These data indicate that the primary structure of maebl is highly conserved among Plasmodium species, while its characteristics demonstrate a function unique among the ebl proteins.

  13. From EBM to EBL: two steps forward or one step back?

    Science.gov (United States)

    Booth, Andrew

    2002-01-01

    The author employs his vantage point as a contributor to Evidence-based Medicine (EBM) and Evidence-based Librarianship (EBL) in the United Kingdom to anticipate obstacles to be overcome by the emerging EBL paradigm. After reviewing and synthesizing three proto-definitions of EBL, he discusses issues around the potential domains to be populated by research findings. He then briefly considers the contribution that critical appraisal skills can make to an evidence-based profession. In concluding that "evidence-based librarianship" is a self-limiting "label," he encourages health information professionals instead to promote the contribution of librarianship to evidence-based practice, a role for which they are uniquely qualified.

  14. Clinical outcome comparison between TIPS and EBL in patients with cirrhosis and portal vein thrombosis.

    Science.gov (United States)

    Wang, Zhu; Zhao, He; Wang, Xiaoze; Zhang, Hailong; Jiang, Mingshan; Tsauo, Jiaywei; Luo, Xuefeng; Yang, Li; Li, Xiao

    2015-08-01

    The aim of this study is to compare the clinical outcomes of transjugular intrahepatic portosystemic shunt (TIPS) and endoscopic band ligation (EBL) in patients with cirrhosis and portal vein thrombosis (PVT). We retrospectively reviewed the January to September 2010 data from our database and included 25 patients with cirrhosis and PVT who underwent successful TIPS creation. We selected another 25 patients who underwent EBL matching for age, sex, and Child-Pugh-Turcotte class. The outcome measures included changes in the PVT status before and after the treatments, the rebleeding rate, and the overall survival. The mean follow-up was 25.1 ± 8.7 months in the EBL group and 25.6 ± 8.5 months in the TIPS group (P = 0.85). After treatments, the PVT severity improved in 40% and worsened in 25% of patients who did not undergo TIPS, compared with 87% and none of the patients who underwent TIPS (P EBL group, and 12.5% and 25.2% in the TIPS group (P = 0.002). The 1- and 2-year survival rates were, respectively, 95.7% and 85.2% in the EBL group, and 96% and 78.7% in the TIPS group (P = 0.203). The MELD score was the only independent predictive factor for survival (HR 1.73, 95% CI 1.27-2.37, P = 0.001). Compared with EBL, TIPS contributed to PVT improvement and reduced the risk of rebleeding without providing a survival benefit for patients with PVT.

  15. Control and eradication programme of enzootic bovine leucosis (EBL) from selected dairy herds in Turkey.

    Science.gov (United States)

    Burgu, I; Alkan, F; Karaoglu, T; Bilge-Dagalp, S; Can-Sahna, K; Güngör, B; Demir, B

    2005-07-01

    Serum samples of 15,909 cattle from 31 dairy herds located in various regions of Turkey were tested for the presence of antibodies against bovine leucosis virus (BLV) using Agar Gel Immuno-diffusion technique (AGID). 48.3% (15/31) of the herds had seropositive animals and positivity rates were detected from 0.5-34.4% in these herds. In an EBL control/eradication programme all seropositive animals were culled in the infected herds. Thereafter, a total of 74,347 sera were tested for the presence of BLV specific antibodies. The serological results and detail of EBL control/eradication programme were shown in this paper.

  16. Optical depth for VHE gamma-rays from distant sources from a generic EBL density

    OpenAIRE

    Raue, M.; Mazin, D.

    2008-01-01

    Very-high-energy (VHE; E>100GeV) gamma-rays from distant sources suffer attenuation through pair-production with low energy photons from the diffuse extragalactic photon fields in the ultraviolet (UV) to far-infrared (FIR) (commonly referred to as Extragalactic Background Light; EBL). When modeling the intrinsic spectra of the VHE gamma-ray sources it is crucial to correctly account for the attenuation. Unfortunately, direct measurements of the EBL are difficult and the knowledge about the EB...

  17. EBL Constraints Using a Sample of TeV Gamma-Ray Emitters Measured with the MAGIC Telescopes

    CERN Document Server

    Mazin, D; Ramazani, V Fallah; Hassan, T; Moralejo, A; Rosillo, M Nievas; Vanzo, G; Acosta, M Vázquez

    2016-01-01

    MAGIC is a stereoscopic system of two Imaging Atmospheric Cherenkov Telescopes operating in the very high energy (VHE) range from about 50 GeV to over 50 TeV. The VHE gamma-ray spectra measured at Earth carry an imprint of the extragalactic background light (EBL) and can be used to study the EBL density and its evolution in time. In the last few years, precision measurements of several blazars in the redshift range from z=0.03 up to z=0.9 were performed with MAGIC obtaining strong limits on the EBL density from single sources. In this paper, we present the results from a combined likelihood analysis using this broad redshift range sample of blazars allowing us to probe the EBL at different wavelengths. The implications on the EBL models and perspectives for future observations with MAGIC are also discussed.

  18. EBL constraints using a sample of TeV gamma-ray emitters measured with the MAGIC telescopes

    Science.gov (United States)

    Mazin, D.; Domínguez, A.; Fallah Ramazani, V.; Hassan, T.; Moralejo, A.; Nievas Rosillo, M.; Vanzo, G.; Vázquez Acosta, M.

    2017-01-01

    MAGIC is a stereoscopic system of two Imaging Atmospheric Cherenkov Telescopes operating in the very high energy (VHE) range from about 50 GeV to over 50 TeV. The VHE gamma-ray spectra measured at Earth carry an imprint of the extra-galactic background light (EBL) and can be used to study the EBL density and its evolution in time. In the last few years, precision measurements of several blazars in the redshift range from z=0.03 up to z=0.9 were performed with MAGIC obtaining strong limits on the EBL density from single sources. In this paper, we present the results from a combined likelihood analysis using this broad redshift range sample of blazars allowing us to probe the EBL at different wavelengths. The implications on the EBL models and perspectives for future observations with MAGIC are also discussed.

  19. EBL effect on the observation of multi-TeV flaring of 2009 from Markarian 501

    CERN Document Server

    Sahu, Sarira; Miranda, Luis Salvador; de León, Alberto Rosales; Gupta, Virendra

    2016-01-01

    Markarian 501 is a high-peaked BL Lacertae object and has undergone many major outburst since its discovery in 1996. As a part of the multiwavelength campaign, in the year 2009 this blazar was observed for 4.5 months from March 9 to August 1 and during the period April 17 to May 5 it was observed by both space and ground based observatories covering the entire electromagnetic spectrum. A very strong high energy $\\gamma$-ray flare was observed on May 1 by Whipple telescope in the energy range 317 GeV to 5 TeV and the flux was about 10 times higher than the baseline flux. We use the photohadronic model complimented by the extragalactic background radiation (EBL) correction to this very high state flare and have shown that the EBL plays an important role in attenuating the very high energy flux even though Markarian 501 is in the local Universe.

  20. Glycophorin B is the erythrocyte receptor of Plasmodium falciparum erythrocyte-binding ligand, EBL-1.

    Science.gov (United States)

    Mayer, D C Ghislaine; Cofie, Joann; Jiang, Lubin; Hartl, Daniel L; Tracy, Erin; Kabat, Juraj; Mendoza, Laurence H; Miller, Louis H

    2009-03-31

    In the war against Plasmodium, humans have evolved to eliminate or modify proteins on the erythrocyte surface that serve as receptors for parasite invasion, such as the Duffy blood group, a receptor for Plasmodium vivax, and the Gerbich-negative modification of glycophorin C for Plasmodium falciparum. In turn, the parasite counters with expansion and diversification of ligand families. The high degree of polymorphism in glycophorin B found in malaria-endemic regions suggests that it also may be a receptor for Plasmodium, but, to date, none has been identified. We provide evidence from erythrocyte-binding that glycophorin B is a receptor for the P. falciparum protein EBL-1, a member of the Duffy-binding-like erythrocyte-binding protein (DBL-EBP) receptor family. The erythrocyte-binding domain, region 2 of EBL-1, expressed on CHO-K1 cells, bound glycophorin B(+) but not glycophorin B-null erythrocytes. In addition, glycophorin B(+) but not glycophorin B-null erythrocytes adsorbed native EBL-1 from the P. falciparum culture supernatants. Interestingly, the Efe pygmies of the Ituri forest in the Democratic Republic of the Congo have the highest gene frequency of glycophorin B-null in the world, raising the possibility that the DBL-EBP family may have expanded in response to the high frequency of glycophorin B-null in the population.

  1. MAGIC observations of the February 2014 flare of 1ES 1011+496 and ensuing constraint of the EBL density

    Science.gov (United States)

    Ahnen, M. L.; Ansoldi, S.; Antonelli, L. A.; Antoranz, P.; Babic, A.; Banerjee, B.; Bangale, P.; Barres de Almeida, U.; Barrio, J. A.; Becerra González, J.; Bednarek, W.; Bernardini, E.; Biasuzzi, B.; Biland, A.; Blanch, O.; Bonnefoy, S.; Bonnoli, G.; Borracci, F.; Bretz, T.; Carmona, E.; Carosi, A.; Chatterjee, A.; Clavero, R.; Colin, P.; Colombo, E.; Contreras, J. L.; Cortina, J.; Covino, S.; Da Vela, P.; Dazzi, F.; De Angelis, A.; De Lotto, B.; de Oña Wilhelmi, E.; Delgado Mendez, C.; Di Pierro, F.; Dominis Prester, D.; Dorner, D.; Doro, M.; Einecke, S.; Eisenacher Glawion, D.; Elsaesser, D.; Fernández-Barral, A.; Fidalgo, D.; Fonseca, M. V.; Font, L.; Frantzen, K.; Fruck, C.; Galindo, D.; García López, R. J.; Garczarczyk, M.; Garrido Terrats, D.; Gaug, M.; Giammaria, P.; Godinović, N.; González Muñoz, A.; Guberman, D.; Hahn, A.; Hanabata, Y.; Hayashida, M.; Herrera, J.; Hose, J.; Hrupec, D.; Hughes, G.; Idec, W.; Kodani, K.; Konno, Y.; Kubo, H.; Kushida, J.; La Barbera, A.; Lelas, D.; Lindfors, E.; Lombardi, S.; Longo, F.; López, M.; López-Coto, R.; López-Oramas, A.; Lorenz, E.; Majumdar, P.; Makariev, M.; Mallot, K.; Maneva, G.; Manganaro, M.; Mannheim, K.; Maraschi, L.; Marcote, B.; Mariotti, M.; Martínez, M.; Mazin, D.; Menzel, U.; Miranda, J. M.; Mirzoyan, R.; Moralejo, A.; Moretti, E.; Nakajima, D.; Neustroev, V.; Niedzwiecki, A.; Nievas Rosillo, M.; Nilsson, K.; Nishijima, K.; Noda, K.; Orito, R.; Overkemping, A.; Paiano, S.; Palacio, J.; Palatiello, M.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Paredes-Fortuny, X.; Persic, M.; Poutanen, J.; Prada Moroni, P. G.; Prandini, E.; Puljak, I.; Rhode, W.; Ribó, M.; Rico, J.; Rodriguez Garcia, J.; Saito, T.; Satalecka, K.; Schultz, C.; Schweizer, T.; Shore, S. N.; Sillanpää, A.; Sitarek, J.; Snidaric, I.; Sobczynska, D.; Stamerra, A.; Steinbring, T.; Strzys, M.; Takalo, L.; Takami, H.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Tescaro, D.; Teshima, M.; Thaele, J.; Torres, D. F.; Toyama, T.; Treves, A.; Verguilov, V.; Vovk, I.; Ward, J. E.; Will, M.; Wu, M. H.; Zanin, R.

    2016-05-01

    Context. During February-March 2014, the MAGIC telescopes observed the high-frequency peaked BL Lac 1ES 1011+496 (z = 0.212) in flaring state at very-high energy (VHE, E> 100 GeV). The flux reached a level of more than ten times higher than any previously recorded flaring state of the source. Aims: To describe the characteristics of the flare presenting the light curve and the spectral parameters of the night-wise spectra and the average spectrum of the whole period. From these data we aim to detect the imprint of the extragalactic background light (EBL) in the VHE spectrum of the source, to constrain its intensity in the optical band. Methods: We analyzed the gamma-ray data from the MAGIC telescopes using the standard MAGIC software for the production of the light curve and the spectra. To constrain the EBL, we implement the method developed by the H.E.S.S. collaboration, in which the intrinsic energy spectrum of the source is modeled with a simple function (≤4 parameters), and the EBL-induced optical depth is calculated using a template EBL model. The likelihood of the observed spectrum is then maximized, including a normalization factor for the EBL opacity among the free parameters. Results: The collected data allowed us to describe the night-wise flux changes and also to produce differential energy spectra for all nights in the observed period. The estimated intrinsic spectra of all the nights could be fitted by power-law functions. Evaluating the changes in the fit parameters, we conclude that the spectral shape for most of the nights were compatible, regardless of the flux level, which enabled us to produce an average spectrum from which the EBL imprint could be constrained. The likelihood ratio test shows that the model with an EBL density 1.07 (-0.20, +0.24)stat+sys, relative to the one in the tested EBL template, is preferred at the 4.6σ level to the no-EBL hypothesis, with the assumption that the intrinsic source spectrum can be modeled as a log

  2. Exogenously Applied 24-Epibrassinolide (EBL) Ameliorates Detrimental Effects of Salinity by Reducing K+ Efflux via Depolarization-Activated K+ Channels.

    Science.gov (United States)

    Azhar, Nazila; Su, Nana; Shabala, Lana; Shabala, Sergey

    2017-04-01

    This study has investigated mechanisms conferring beneficial effects of exogenous application of 24-epibrassinolides (EBL) on plant growth and performance under saline conditions. Barley seedlings treated with 0.25 mg l-1 EBL showed significant improvements in root hair length, shoot length, shoot fresh weight and relative water content when grown in the presence of 150 mM NaCl in the growth medium. In addition, EBL treatment significantly decreased the Na+ content in both shoots (by approximately 50%) and roots. Electrophysiological experiments revealed that pre-treatment with EBL for 1 and 24 h suppressed or completely prevented the NaCl-induced K+ leak in the elongation zone of barley roots, but did not affect root sensitivity to oxidative stress. Further experiments using Arabidopsis loss-of-function gork1-1 (lacking functional depolarization-activated outward-rectifying K+ channels in the root epidermal cells) and akt1 (lacking inward-rectifying K+ uptake channel) mutants showed that NaCl-induced K+ loss in the elongation zone of roots was reduced by EBL pre-treatment 50- to 100-fold in wild-type Col-0 and akt1, but only 10-fold in the gork1-1 mutant. At the same time, EBL treatment shifted vanadate-sensitive H+ flux towards net efflux. Taken together, these data indicate that exogenous application of EBL effectively improves plant salinity tolerance by prevention of K+ loss via regulating depolarization-activated K+ channels. © The Author 2017. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  3. Design and fabrication of Si-based photonic crystal stamps with electron beam lithography (EBL)

    Science.gov (United States)

    Jannesary, Reyhaneh; Bergmair, Iris; Zamiri, Saeid; Hingerl, Kurt; Hubbard, Graham; Abbott, Steven; Chen, Qin; Allsopp, Duncan

    2009-05-01

    The quest for mass replication has established technologies like nanoimprinting via hard stamps or PDMS stamps, where the stamps are usually produced via Electron Beam Lithography (EBL) for applications in the microelectronic industry. On the other hand, nanopatterning with self ordered structures1 or via holographic patterns provide the basis for large area imprints for applications for example, antireflection coatings based on biomimetic motheyes2. In this work we report on a technology for enabling the mass replication of custom-designed and e-beam lithographically prepared structures via establishing novel roll to roll nanoimprint processes for pattern transfer into UV curable pre-polymers. The new nano-fabrication technology is based on the concept of Disposal Master Technology (DMT) capable of patterning areas up to 1 x 1 m2 and is suitable for mass volume manufacturing of large area arrays of sub-wavelength photonic elements. As an example to show the potential of the application of the new nanoimprint technologies, we choose the fabrication of a photonic crystal (PhC) structure with integrated light coupling devices for low loss interconnection between PhC lightwave circuits and optical fibre systems. We present two methods for fabrication of nanoimprint lithography stamps in Si substrate. In the first method optimized electron beam lithography (EBL) and lift-off patterning of a 15-nm thick Cr mask, and then the pattern transfer into Si using reacting ion etching (RIE) with SF6 as etch gas. In the first method, we use 200nm of positive resist PMMA 950K for EBL exposure. In this method, resist thickness, exposure dose, development time and parameter for etching have been optimized and a photonic crystal of Si-rods in air was fabricated. In the second method lift-off has not been performed and metal mask has been used as master. The subsequent steps for fabricating the master will be presented in detail.

  4. Inzicht door onderdompeling Een reactie op Bart Van de Putte, Henk de Smaele en Dirk Jan Wolffram

    Directory of Open Access Journals (Sweden)

    Jan Hein Furnée

    2014-09-01

    Full Text Available Giving a detailed account of the social history of The Hague’s most prominent sites of civilised leisure – the gentlemen’s clubs, the zoo, the Royal Theatre and the seaside resort of Scheveningen – Plaatsen van beschaafd vertier demonstrates how the constant struggle for social in- and exclusion structured the daily lives of upper and middle class men and women in The Hague in the nineteenth century. In response to Bart Van de Putte, Jan Hein Furnée argues that extensive quantitative analyses of ‘class’ and ‘social class’ show that objective class stratifications based onwealth and/or occupation are important tools, but at most semi-finished products for historical research. Furnée fully agrees with Henk de Smaele’s objection that his study would have benefitted from a more in-depth reflection on the ways in which shifting patterns in women’s freedom of movement in urban spaces were related to their political and economic emancipation. In response to Dirk Jan Wolffram, Furnée repeats some examples given in his book that show how political practices in places of leisure impacted upon local and national politics, even though this didnot directly contribute to a linear process of increasing political participation and representation.Aan de hand van een gedetailleerde analyse van de sociale geschiedenis van herenen burgersociëteiten, de dierentuin, de Koninklijke Schouwburg en badplaats Scheveningen demonstreert Plaatsen van beschaafd vertier hoe de constante strijd om sociale in- en uitsluiting het dagelijks leven van mannen en vrouwen uit de hogere en middenstanden in negentiende-eeuws Den Haag beheerste. In reactie op Bart Van de Putte betoogt Jan Hein Furnée dat grondige kwantitatieve analyses van ‘class’ en ‘social class’ uitwijst dat objectieve sociale stratificaties op basis van welstand en/of beroep voor historisch onderzoek weliswaar zeer nuttig enzelfs noodzakelijk, maar uiteindelijk slechts een

  5. Inzicht door onderdompeling Een reactie op Bart Van de Putte, Henk de Smaele en Dirk Jan Wolffram

    Directory of Open Access Journals (Sweden)

    Jan Hein Furnée

    2014-09-01

    Full Text Available Giving a detailed account of the social history of The Hague’s most prominent sites of civilised leisure – the gentlemen’s clubs, the zoo, the Royal Theatre and the seaside resort of Scheveningen – Plaatsen van beschaafd vertier demonstrates how the constant struggle for social in- and exclusion structured the daily lives of upper and middle class men and women in The Hague in the nineteenth century. In response to Bart Van de Putte, Jan Hein Furnée argues that extensive quantitative analyses of ‘class’ and ‘social class’ show that objective class stratifications based onwealth and/or occupation are important tools, but at most semi-finished products for historical research. Furnée fully agrees with Henk de Smaele’s objection that his study would have benefitted from a more in-depth reflection on the ways in which shifting patterns in women’s freedom of movement in urban spaces were related to their political and economic emancipation. In response to Dirk Jan Wolffram, Furnée repeats some examples given in his book that show how political practices in places of leisure impacted upon local and national politics, even though this didnot directly contribute to a linear process of increasing political participation and representation.Aan de hand van een gedetailleerde analyse van de sociale geschiedenis van herenen burgersociëteiten, de dierentuin, de Koninklijke Schouwburg en badplaats Scheveningen demonstreert Plaatsen van beschaafd vertier hoe de constante strijd om sociale in- en uitsluiting het dagelijks leven van mannen en vrouwen uit de hogere en middenstanden in negentiende-eeuws Den Haag beheerste. In reactie op Bart Van de Putte betoogt Jan Hein Furnée dat grondige kwantitatieve analyses van ‘class’ en ‘social class’ uitwijst dat objectieve sociale stratificaties op basis van welstand en/of beroep voor historisch onderzoek weliswaar zeer nuttig enzelfs noodzakelijk, maar uiteindelijk slechts een

  6. Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): enzootic bovine leukosis (EBL)

    DEFF Research Database (Denmark)

    EFSA Panel on Animal Health and Welfare; More, Simon J.; Bøtner, Anette

    2017-01-01

    Enzootic bovine leucosis (EBL) has been assessed according to the criteria of the Animal Health Law (AHL), in particular criteria of Article 7 on disease profile and impacts, Article 5 on the eligibility of EBL to be listed, Article 9 for the categorisation of EBL according to disease prevention...... and control rules as in Annex IV and Article 8 on the list of animal species related to EBL. The assessment has been performed following a methodology composed of information collection and compilation, expert judgement on each criterion at individual and, if no consensus was reached before, also......, it is inconclusive whether EBL can be considered eligible to be listed for Union intervention as laid down in Article 5(3) of the AHL because there was no full consensus on the criteria 5 B(i) and 5 B(iii). Consequently, since it is inconclusive whether EBL can be considered eligible to be listed for Union...

  7. Specific erythrocyte binding capacity and biological activity of Plasmodium falciparum erythrocyte binding ligand 1 (EBL-1)-derived peptides.

    Science.gov (United States)

    Curtidor, Hernando; Rodríguez, Luis E; Ocampo, Marisol; López, Ramses; García, Javier E; Valbuena, John; Vera, Ricardo; Puentes, Alvaro; Vanegas, Magnolia; Patarroyo, Manuel E

    2005-02-01

    Erythrocyte binding ligand 1 (EBL-1) is a member of the ebl multigene family involved in Plasmodium falciparum invasion of erythrocytes. We found that five EBL-1 high-activity binding peptides (HABPs) bound specifically to erythrocytes: 29895 ((41)HKKKSGELNNNKSGILRSTY(60)), 29903 ((201)LYECGK-KIKEMKWICTDNQF(220)), 29923 ((601)CNAILGSYADIGDIVRGLDV(620)), 29924((621)WRDINTNKLSEK-FQKIFMGGY(640)), and 30018 ((2481)LEDIINLSKKKKKSINDTSFY(2500)). We also show that binding was saturable, not sialic acid-dependent, and that all peptides specifically bound to a 36-kDa protein on the erythrocyte membrane. The five HABPs inhibited in vitro merozoite invasion depending on the peptide concentration used, suggesting their possible role in the invasion process.

  8. Successful en bloc resection of an esophageal hemangioma by combined EBL & EMR: a case report and technical review.

    Science.gov (United States)

    Baek, Il Hyun; Jeon, Jung Won; Shin, Hyun Phil; Cha, Jae Myung; Joo, Kwang Ro; Lee, Joung Il; Won, Kyu Yeoun; Min, Kyeong Won

    2016-01-01

    A 58-year-old male was diagnosed esophageal hemangioma during a endoscopy in regular examination. The patient was referred to the department of gastroenterology in our hospital to treatment. Combined endoscopic band ligation (EBL) and endoscopic mucosal resection (EMR) was performed for diagnostic treatment. Histopathological results revealed hemangioma. Even though several approaches such as esophagectomy, endoscopic removal, sclerotherapy, and laser therapy have been used to remove the esophageal hemangiomas, recently less invasive methods were preferred. Here we describe a case of esophageal hemangioma removed by EBL & EMR.

  9. P19 contributes to Mycoplasma mycoides subsp. mycoides adhesion to EBL cells.

    Science.gov (United States)

    Zhou, Yumei; Wang, Yang; Li, Yuan; Nick, Nwankpa; Zou, Xiaohui; Bai, Fan; Wu, Jindi; Xin, Jiuqing

    2016-04-01

    Mycoplasma mycoides subsp. mycoides (Mmm) is the causative agent of contagious bovine pleuropneumonia (CBPP). The virulent Mmm Ben-1 strain was isolated from the lung of a CBPP-infected cow in China in the 1950s. To attenuate the virulence of the Ben-1 strain and preserve its protective ability, the isolate was re-isolated after inoculation into the testicles of rabbits and into the rabbit thorax. As a result, after the subsequent isolates were continuously passaged 468 times in rabbits, its pathogenicity to cattle decreased. However, the molecular mechanisms leading to attenuation of the Mmm Ben-1 remain unknown. We compared the entire genomes of the Ben-1 strain and the 468 th generation strain passaged in rabbits (Ben-468) and discovered that a putative protein gene named p19 was absent from the Ben-468 strain. The p19 gene was cloned and expressed in Escherichia coli to obtain recombinant P19 (rP19). Western blot analysis demonstrated that the P19 protein is detected in the cell-membrane fraction, the cell-soluble cytosolic fraction and whole-cell lysate of the Mmm Ben-1 strain. The rP19 can interact with international standard serum against CBPP. Immunostaining visualised via confocal laser scanning microscopy indicated that P19 is able to adhere to embryonic bovine lung (EBL) cells, and this finding was also confirmed by a sandwich ELISA. We also found that anti-rP19 serum could inhibit the adhesion of the Mmm Ben-1 total proteins to EBL cells. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. MAGIC observations of the February 2014 flare of 1ES 1011+496 and ensuing constraint of the EBL density

    CERN Document Server

    Ahnen, M L; Antonelli, L A; Antoranz, P; Babic, A; Banerjee, B; Bangale, P; de Almeida, U Barres; Barrio, J A; González, J Becerra; Bednarek, W; Bernardini, E; Biasuzzi, B; Bil, A; Blanch, O; Bonnefoy, S; Bonnoli, G; Borracci, F; Bretz, T; Carmona, E; Carosi, A; Chatterjee, A; Clavero, R; Colin, P; Colombo, E; Contreras, J L; Cortina, J; Covino, S; Da Vela, P; Dazzi, F; De Angelis, A; De Lotto, B; Wilhelmi, E de O na; Mendez, C Delgado; Di Pierro, F; Prester, D Dominis; Dorner, D; Doro, M; Einecke, S; Glawion, D Eisenacher; Elsaesser, D; Fernández-Barral, A; Fidalgo, D; Fonseca, M V; Font, L; Frantzen, K; Fruck, C; Galindo, D; López, R J García; Garczarczyk, M; Terrats, D Garrido; Gaug, M; Giammaria, P; Godinovic, N; Muñoz, A González; Guberman, D; Hahn, A; Hanabata, Y; Hayashida, M; Herrera, J; Hose, J; Hrupec, D; Hughes, G; Idec, W; Kodani, K; Konno, Y; Kubo, H; Kushida, J; La Barbera, A; Lelas, D; Lindfors, E; Lombardi, S; Longo, F; López, M; López-Coto, R; López-Oramas, A; Lorenz, E; Majumdar, P; Makariev, M; Mallot, K; Maneva, G; Manganaro, M; Mannheim, K; Maraschi, L; Marcote, B; Mariotti, M; Martínez, M; Mazin, D; Menzel, U; Mira, J M; Mirzoyan, R; Moralejo, A; Moretti, E; Nakajima, D; Neustroev, V; Niedzwiecki, A; Rosillo, M Nievas; Nilsson, K; Nishijima, K; Noda, K; Orito, R; Overkemping, A; Paiano, S; Palacio, J; Palatiello, M; Paneque, D; Paoletti, R; Paredes, J M; Paredes-Fortuny, X; Persic, M; Poutanen, J; Moroni, P G Prada; Prini, E; Puljak, I; Rhode, W; Ribó, M; Rico, J; Garcia, J Rodriguez; Saito, T; Satalecka, K; Schultz, C; Schweizer, T; Shore, S N; Sillanpaa, A; Sitarek, J; Snidaric, I; Sobczynska, D; Stamerra, A; Steinbring, T; Strzys, M; Takalo, L; Takami, H; Tavecchio, F; Temnikov, P; Terzic, T; Tescaro, D; Teshima, M; Thaele, J; Torres, D F; Toyama, T; Treves, A; Verguilov, V; Vovk, I; Ward, J E; Will, M; Wu, M H; Zanin, R

    2016-01-01

    In February-March 2014, the MAGIC telescopes observed the high-frequency peaked BL Lac 1ES 1011+496 (z=0.212) in flaring state at very-high energy (VHE, E>100GeV). The flux reached a level more than 10 times higher than any previously recorded flaring state of the source. We present the description of the characteristics of the flare presenting the light curve and the spectral parameters of the night-wise spectra and the average spectrum of the whole period. From these data we aim at detecting the imprint of the Extragalactic Background Light (EBL) in the VHE spectrum of the source, in order to constrain its intensity in the optical band. For this we implement the method developed by the H.E.S.S. collaboration in which the intrinsic energy spectrum of the source is modeled with a simple function, and the EBL-induced optical depth is calculated using a template EBL model. The likelihood of the observed spectrum is then maximized, including a normalization factor for the EBL opacity among the free parameters. F...

  11. EBL-1, a putative erythrocyte binding protein of Plasmodium falciparum, maps within a favored linkage group in two genetic crosses.

    Science.gov (United States)

    Peterson, D S; Wellems, T E

    2000-01-05

    The Duffy binding-like (DBL) superfamily of Plasmodium falciparum encompasses genes which encode ligands for host cell receptors. This superfamily includes two distinct groups of genes, the var genes which encode antigenically variant cytoadherence proteins (PfEMP1), and the eba-175 gene which encodes a glycophorin A binding protein involved in erythrocyte invasion. Here we describe another DBL superfamily member related to eba-175, the ebl-1 gene. Like the eba-175 gene, ebl-1 is a single copy gene encoding DBL domains that have sequences and an overall arrangement distinct from var genes. The inheritance of ebl-1 was found to be strongly favored in two genetic crosses in which one parental clone lacked a chromosome segment carrying the gene. A proliferation phenotype has been previously linked to the same chromosome segment in the first genetic cross. These results suggest that ebl-1 and eba-175 are related members of a multigene family involved in the invasion of erythrocytes by P. falciparum.

  12. Comparison of the solution conformations of a cell-adhesive peptide LBE and its reverse sequence EBL.

    Science.gov (United States)

    Jois, S D; Hughes, R; Siahaan, T J

    1999-12-01

    T-cell adhesion is mediated by an ICAM-1/LFA-1 interaction; this interaction plays a crucial role in T-cell activation during immune response. LBE peptide, which is derived from the beta-subunit of LFA-1, has been shown to inhibit ICAM-1/LFA-1-mediated T-cell adhesion. In this work, we studied the solution conformations of LBE peptide and its reverse sequence (EBL) by NMR, CD and molecular dynamics simulations. Reverse peptides have been used as controls in biological studies. The effect of reversing the sequence of LBE to EBL peptides on their respective conformations is important in understanding their biological properties in vitro or in vivo. The NMR studies for these peptides were carried out in water and in TFE/water solvent systems. In 40% TFE/water, both peptides exhibited helical conformation. CD studies suggested that the LBE exhibits 30% helical conformation, while the EBL exhibits 20% helical conformation. From the NMR and MD simulation studies, it was evident that the peptides exhibited a stable helical conformation; a stable helical structure was found at Leu6 to Leu15 for LBE and at Gly9 to Leu17 for EBL. The helical conformations of LBE and EBL may be in equilibrium with other possible conformers; the other conformers contain loop and turn structures. Both peptides bind to divalent cations because the LBE is derived from the cation-binding region of the LFA-1. This study shows that reversing the peptide sequence did not alter the secondary structure of the corresponding sequence. Hence, caution must be exercised when using reverse peptides as controls in biological studies. This report will improve our ability to design a better inhibitor of ICAM-1/LFA-1 interaction.

  13. Jets, Blazars and the EBL in the GLAST-EXIST Era

    CERN Document Server

    Grindlay, Jonathan E

    2007-01-01

    The synergy of GLAST and the proposed EXIST mission as the Black Hole Finder Probe in the Beyond Einstein Program is remarkable. With its full-sky per orbit hard X-ray imaging (3-600 keV) and "nuFnu" sensitivity comparable to GLAST, EXIST could measure variability and spectra of Blazars in the hard X-ray synchrotron component simultaneous with GLAST (~10-100GeV) measures of the inverse Compton component, thereby uniquely constraining intrinsic source spectra and allowing measured high energy spectral breaks to measure the cosmic diffuse extra-galactic background light (EBL) by determining the intervening diffuse IR photon field required to yield the observed break from photon-photon absorption. Such studies also constrain the physics of jets (and parameters and indeed the validity of SSC models) and the origin of the >100 MeV gamma-ray diffuse background likely arising from Blazars and jet-dominated sources. An overview of the EXIST mission, which could fly in the GLAST era, is given together with a synopsis ...

  14. EBL effect on the observation of multi-TeV flaring of 2009 from Markarian 501

    Energy Technology Data Exchange (ETDEWEB)

    Sahu, Sarira; Lemus Yanez, Marco Vladimir; Salvador Miranda, Luis; Rosales de Leon, Alberto [Universidad Nacional Autonoma de Mexico, Instituto de Ciencias Nucleares (Mexico); Gupta, Virendra [Centro de Investigacion y de Estudios Avanzandos del IPN Unidad Merida, Departamento de Fisica Aplicada, Yucatan (Mexico)

    2017-01-15

    Markarian 501 is a high-peaked BL Lacertae object and has undergone many major outbursts since its discovery in 1996. As a part of the multiwavelength campaign, in the year 2009 this blazar was observed for 4.5 months from March 9 to August 1 and during the period April 17 to May 5 it was observed by both space and ground based observatories covering the entire electromagnetic spectrum. A very strong high energy γ-ray flare was observed on May 1 by Whipple telescope in the energy range 317 GeV to 5 TeV and the flux was about 10 times higher than the average baseline flux. Previously during 1997 Markarian 501 had undergone another long outburst, which was observed by HEGRA telescopes and the energy spectrum was well beyond 10 TeV. The photohadronic model complemented by the extragalactic background radiation (EBL) correction fits well with the flares data observed by both Whipple and HEGRA. Our model predicts a steeper slope of the energy spectrum beyond 10 TeV, which is compatible with the improved analysis of the HEGRA data. (orig.)

  15. EBL effect on the observation of multi-TeV flaring of 2009 from Markarian 501

    Science.gov (United States)

    Sahu, Sarira; Yáñez, Marco Vladimir Lemus; Miranda, Luis Salvador; de León, Alberto Rosales; Gupta, Virendra

    2017-01-01

    Markarian 501 is a high-peaked BL Lacertae object and has undergone many major outbursts since its discovery in 1996. As a part of the multiwavelength campaign, in the year 2009 this blazar was observed for 4.5 months from March 9 to August 1 and during the period April 17 to May 5 it was observed by both space and ground based observatories covering the entire electromagnetic spectrum. A very strong high energy γ -ray flare was observed on May 1 by Whipple telescope in the energy range 317 GeV to 5 TeV and the flux was about 10 times higher than the average baseline flux. Previously during 1997 Markarian 501 had undergone another long outburst, which was observed by HEGRA telescopes and the energy spectrum was well beyond 10 TeV. The photohadronic model complemented by the extragalactic background radiation (EBL) correction fits well with the flares data observed by both Whipple and HEGRA. Our model predicts a steeper slope of the energy spectrum beyond 10 TeV, which is compatible with the improved analysis of the HEGRA data.

  16. Model based correction of placement error in EBL and its verification

    Science.gov (United States)

    Babin, Sergey; Borisov, Sergey; Militsin, Vladimir; Komagata, Tadashi; Wakatsuki, Tetsuro

    2016-05-01

    In maskmaking, the main source of error contributing to placement error is charging. DISPLACE software corrects the placement error for any layout, based on a physical model. The charge of a photomask and multiple discharge mechanisms are simulated to find the charge distribution over the mask. The beam deflection is calculated for each location on the mask, creating data for the placement correction. The software considers the mask layout, EBL system setup, resist, and writing order, as well as other factors such as fogging and proximity effects correction. The output of the software is the data for placement correction. One important step is the calibration of physical model. A test layout on a single calibration mask was used for calibration. The extracted model parameters were used to verify the correction. As an ultimate test for the correction, a sophisticated layout was used for the verification that was very different from the calibration mask. The placement correction results were predicted by DISPLACE. A good correlation of the measured and predicted values of the correction confirmed the high accuracy of the charging placement error correction.

  17. Modelli di acquisto di e-book per le biblioteche dell'università italiana. Tre piattaforme a confronto (EBL, Ebrary, Ebsco)

    National Research Council Canada - National Science Library

    Giovanna Frigimelica

    2014-01-01

    ... to the selection and acquisition of ebooks. The article analyzes three platforms (EBL, Ebrary, EBSCO), to find out whether an Italian medium-sized university library can buy foreign titles in electronic rather than paper, and under what conditions...

  18. Die betekenis van ds. Dirk Postma se bevordering van Christelike onderwys vir negentiende-eeuse Nederland en vir Suid-Afrika vandag

    Directory of Open Access Journals (Sweden)

    W. Postma

    1993-03-01

    Full Text Available The Rev. Dirk Postma was not only the founder of the Reformed Church of South Africa (Gereformeerde Kerk, but also made significant contributions in the field of education. In this article the leading role he played with regard to the promotion of Christian education in the Netherlands (IH4H-1859 and in South Africa (1859-1890 is outlined. He was responsible for the establishment of the first Christian school in Zwolle and his dynamic involvement in education in South Africa had the result, among others, that the Potchefstroom University for Christian Higher Education came into being. His worthwhile activities in the sen’icc of Christian education are an example for present-day Christian educators in South Africa to tackle the educational problems which are rife at present and possibly to solve them in a like manner.

  19. High-throughput ultrasensitive characterization of chemical, structural and plasmonic properties of EBL-fabricated single silver nanoparticles.

    Science.gov (United States)

    Huang, Tao; Cao, Wei; Elsayed-Ali, Hani E; Xu, Xiao-Hong Nancy

    2012-01-21

    Electron beam lithography (EBL) has become a popular means to prepare a wide variety of nano-arrays for numerous studies and applications, including photonics and sensors. Their fabrications and characterizations are costly and time consuming, underscoring the importance of developing effective tools to rapidly study their physicochemical stabilities and properties over time. In this study, we characterized EBL-fabricated single silver nanoparticle (Ag NP) arrays over their 12-week exposure to ambient conditions using SEM/EDS, AFM and dark-field optical microscopy and spectroscopy (DFOMS). We found that chemical compositions, structural morphologies and plasmonic optical properties of single NPs altered drastically over the exposure. Single cuboid and triangular-prism Ag NPs degraded at rates of (0.74 ± 0.02) and (0.66 ± 0.02) per week, and their localized surface plasmon resonance (LSPR) spectra showed striking blue-shifts (171 ± 25 and 203 ± 35 nm) over the 12-week exposure, respectively. Plasmonic colors of single NPs changed distinctively from red to green over the 12-week exposure. The LSPR spectra of individual NPs in each array were acquired simultaneously and correlated specifically with their SEM and AFM images, demonstrating that DFOMS can serve as high-throughput, ultrasensitive and non-invasive means to characterize chemical, structural and optical properties of nano-arrays in situ in real time at single-NP resolution.

  20. KAJIAN EKONOMI KONSTRUKSI PERKERASAN LENTUR DAN KONSTRUKSI PERKERASAN KAKU (STUDI KASUS JALAN RAYA PKT.EBL-02 TOHPATI - KUSAMBA

    Directory of Open Access Journals (Sweden)

    Hevie Tri Hary Astuti

    2014-02-01

    Full Text Available This study takes the case PKT. EBL highway Tohpati – 02 – Kusamba.The purpose of this study was to conduct economic studies flexible pavement and rigid pavement based on primary data and secondary data obtained from government agencies, the analysis in this study using the methode of costs and benefits. For flexible pavement; assuming traffic growth factor of 3.66%, inflation at 5.68% and the interest rate of 15% / year, 25% / year and 30% / year, and the fluctuating value of IRI. The results obtained for the 15% interest rate per year is NPV = Rp. 98,517,603,656, -, BCR = 1.42; interest rate to 25% per year is NPV = Rp. (65,520,977,844, -, BCR = 0.96; interest rate to 30% per year is NPV = Rp. (69,846,272,752, -, BCR = 0.51, moderate IRR = 24.38%. It can be concluded that the Highway Pavement Bending PKT.EBL-02 Tohpati - Kusamba is economically feasible at the rate of 15% per year with an IRR above. For Rigid Pavement; assuming traffic growth factor of 3.66%, inflation at 5.68% and the interest rate of 15% / year, 25% / year and 30% / year, and the value of IRI stable. The results obtained for the 15% interest rate per year is NPV = Rp. 159 515 604 651, -, BCR = 2.20; interest rate to 25% per year is NPV = Rp. 2068846698, -, BCR = 1.01; interest rate to 30% per year is NPV = Rp. (65,250,533,141, -, BCR = 0.51, moderate IRR = 25.15%. It can be concluded that the Rigid Pavement on Highway-02 PKT.EBL Tohpati - Kusamba is economically feasible at the rate of 15% per annum and 25% per year with an IRR above. In the concluding remarks of the above where rigid pavement IRR greater than the flexible pavement, the results of the economic analysis of this study is that the rigid pavement is more profitable than the flexible pavement.

  1. A conserved region in the EBL proteins is implicated in microneme targeting of the malaria parasite Plasmodium falciparum.

    Science.gov (United States)

    Treeck, Moritz; Struck, Nicole S; Haase, Silvia; Langer, Christine; Herrmann, Susann; Healer, Julie; Cowman, Alan F; Gilberger, Tim W

    2006-10-20

    The proliferation of the malaria parasite Plasmodium falciparum within the human host is dependent upon invasion of erythrocytes. This process is accomplished by the merozoite, a highly specialized form of the parasite. Secretory organelles including micronemes and rhoptries play a pivotal role in the invasion process by storing and releasing parasite proteins. The mechanism of protein sorting to these compartments is unclear. Using a transgenic approach we show that trafficking of the most abundant micronemal proteins (members of the EBL-family: EBA-175, EBA-140/BAEBL, and EBA-181/JSEBL) is independent of their cytoplasmic and transmembrane domains, respectively. To identify the minimal sequence requirements for microneme trafficking, we generated parasites expressing EBA-GFP chimeric proteins and analyzed their distribution within the infected erythrocyte. This revealed that: (i) a conserved cysteine-rich region in the ectodomain is necessary for protein trafficking to the micronemes and (ii) correct sorting is dependent on accurate timing of expression.

  2. Microbowl-arrayed surface generated by EBL of negative-tone SU-8 for highly adhesive hydrophobicity

    Energy Technology Data Exchange (ETDEWEB)

    Li, Xiangmeng, E-mail: xiangmengli2010@stu.xjtu.edu.cn; Shao, Jinyou, E-mail: jyshao@mail.xjtu.edu.cn; Ding, Yucheng, E-mail: ycding@mail.xjtu.edu.cn; Tian, Hongmiao, E-mail: tian.hongmiao@stu.xjtu.edu.cn

    2014-07-01

    A unique microbowl-arrayed surface demonstrates highly adhesive hydrophobicity similar to a rose-petal. Such a textured surface is generated by electron beam lithography on negative-tone SU-8 resist with X–Y cross-lines scanning. The microbowl array patterned surface possesses an advancing contact angle of 160° and a contact angle hysteresis of 90°, and it is capable of holding a 50 μl aqueous droplet as positioned perpendicularly. The wetting properties of adhesive hydrophobicity can be tuned by varying the exposure dosage in EBL as well as the thickness of the fluorocarbon deposition, both of which can change the curvature of microbowl array with submicron-ridges. Therefore, the contact state on such microbowl-arrayed surfaces can be varied from Cassie–Baxter's to Wenzel's model.

  3. Draft Genome Sequence of Bacillus amyloliquefaciens EBL11, a New Strain of Plant Growth-Promoting Bacterium Isolated from Rice Rhizosphere

    Science.gov (United States)

    Wang, Yinghuan; Greenfield, Paul; Jin, Decai

    2014-01-01

    Bacillus amyloliquefaciens strain EBL11 is a bacterium that can promote plant growth by inhibiting the growth of fungi on plant surfaces and providing nutrients as a nonchemical biofertilizer. The estimated genome of this strain is 4.05 Mb in size and harbors 3,683 coding genes (CDSs). PMID:25059875

  4. Identification of a specific region of Plasmodium falciparum EBL-1 that binds to host receptor glycophorin B and inhibits merozoite invasion in human red blood cells.

    Science.gov (United States)

    Li, Xuerong; Marinkovic, Marina; Russo, Crystal; McKnight, C James; Coetzer, Theresa L; Chishti, Athar H

    2012-05-01

    The malaria parasite Plasmodium falciparum invades human erythrocytes through multiple pathways utilizing several ligand-receptor interactions. These interactions are broadly classified in two groups according to their dependency on sialic acid residues. Here, we focus on the sialic acid-dependent pathway by using purified glycophorins and red blood cells (RBCs) to screen a cDNA phage display library derived from P. falciparum FCR3 strain, a sialic acid-dependent strain. This screen identified several parasite proteins including the erythrocyte-binding ligand-1, EBL-1. The phage cDNA insert encoded the 69-amino acid peptide, termed F2i, which is located within the F2 region of the DBL domain, designated here as D2, of EBL-1. Recombinant D2 and F2i polypeptides bound to purified glycophorins and RBCs, and the F2i peptide was found to interfere with binding of D2 domain to its receptor. Both D2 and F2i polypeptides bound to trypsin-treated but not neuraminidase or chymotrypsin-treated erythrocytes, consistent with known glycophorin B resistance to trypsin, and neither the D2 nor F2i polypeptide bound to glycophorin B-deficient erythrocytes. Importantly, purified D2 and F2i polypeptides partially inhibited merozoite reinvasion in human erythrocytes. Our results show that the host erythrocyte receptor glycophorin B directly interacts with the DBL domain of parasite EBL-1, and the core binding site is contained within the 69 amino acid F2i region (residues 601-669) of the DBL domain. Together, these findings suggest that a recombinant F2i peptide with stabilized structure could provide a protective function at blood stage infection and represents a valuable addition to a multi-subunit vaccine against malaria. Copyright © 2012 Elsevier B.V. All rights reserved.

  5. Modelli di acquisto di e-book per le biblioteche dell'università italiana. Tre piattaforme a confronto (EBL, Ebrary, Ebsco

    Directory of Open Access Journals (Sweden)

    Giovanna Frigimelica

    2014-01-01

    Full Text Available Negli ultimi anni la diffusione degli e-book ha avuto una crescita esponenziale. L'accesso 24 ore su 24, la portabilità, gli strumenti avanzati offerti dalle piattaforme rendono questo prodotto particolarmente interessante in ambito accademico. Le biblioteche si trovano ad attraversare una fase di sperimentazione per quanto concerne la selezione e l'acquisizione degli e-book. L'articolo analizza tre piattaforme (EBL, Ebrary, EBSCO in particolare con l'ottica di stabilire se un'università italiana di medie dimensioni possa acquistare titoli stranieri in versione elettronica anziché cartacea, e a che condizioni. Vengono presentate informazioni sul catalogo offerto, i business model, le funzionalità disponibili. Il taglio è pratico/sperimentale, in quanto i paragoni tra le piattaforme si basano su un set di 150 monografie, pubblicate negli ultimi 5 anni da editori diversi e acquistate in cartaceo, utilizzato come campione rappresentativo.

  6. Modelli di acquisto di e-book per le biblioteche dell'università italiana. Tre piattaforme a confronto (EBL, Ebrary, Ebsco

    Directory of Open Access Journals (Sweden)

    Giovanna Frigimelica

    2014-01-01

    Full Text Available In recent years, the spread of ebooks has grown exponentially. 24/7 availability, portability, the advanced tools offered by platforms make this product particularly interesting for academic libraries, which are in an experimental phase with regard to the selection and acquisition of ebooks. The article analyzes three platforms (EBL, Ebrary, EBSCO, to find out whether an Italian medium-sized university library can buy foreign titles in electronic rather than paper, and under what conditions. It provides information about titles catalog, business models, features available. The cut is practical/experimental, since the comparison among the platforms is based on a set, used as a representative sample, of 150 monographs, published in the last 5 years by different publishers and purchased on paper.

  7. Prevalence of 5' insertion mutants and analysis of single nucleotide polymorphism in the erythrocyte binding-like 1 (ebl-1) gene in Kenyan Plasmodium falciparum field isolates.

    Science.gov (United States)

    Githui, Elijah K; Peterson, David S; Aman, Rashid A; Abdi, Abdirahman I

    2010-08-01

    Plasmodium merozoites attach to and invade red blood cells (RBCs) during the erythrocytic cycle. The invasion process requires recognition of RBC surface receptors by proteins of the Plasmodium Duffy binding like erythrocyte binding like (DBL-EBP) family. Clones and isolates of Plasmodium falciparum have varying abilities to utilize different RBC receptors, and multiple distinct pathways so far identified depend on glycophorins A, B, C, and as yet unidentified receptors. At present, five members of the DBL-EBP family have been identified in the P. falciparum genome, based on gene structure and amino acid sequence homology. The cardinal features of this family consist of conserved 5' and 3' cysteine-rich regions (regions II and VI, respectively) whose cysteine residues are highly conserved along with the majority of aromatic amino acids. In contrast to the single DBL-EBP family member in Plasmodium vivax, in P. falciparum all DBL-EBP family members have a duplication of the conserved 5' cysteine-rich region denoted as the F1 and F2 domains. These cysteine-rich regions are considered crucial in recognition of erythrocyte receptors and it has been shown that several bind to glycophorins on the erythrocyte surface. Several studies, on both field isolates and laboratory strains have uncovered a relatively high degree of sequence polymorphism in the DBP-EBL genes. This study is now extended to include field isolates collected from sites within Kenya. DNA isolated from blood samples of infected patients was utilized to amplify the region I sequence of ebl-1 gene in order to investigate polymorphism in the region immediately adjacent to the 5' cysteine-rich domains, and to determine the prevalence of an insertion mutant that effectively knocks out the gene. Copyright 2009 Elsevier B.V. All rights reserved.

  8. De novo assembly and transcriptome analysis of Plasmodium gallinaceum identifies the Rh5 interacting protein (ripr), and reveals a lack of EBL and RH gene family diversification.

    Science.gov (United States)

    Lauron, Elvin J; Aw Yeang, Han Xian; Taffner, Samantha M; Sehgal, Ravinder N M

    2015-08-05

    Malaria parasites that infect birds can have narrow or broad host-tropisms. These differences in host specificity make avian malaria a useful model for studying the evolution and transmission of parasite assemblages across geographic ranges. The molecular mechanisms involved in host-specificity and the biology of avian malaria parasites in general are important aspects of malaria pathogenesis that warrant further examination. Here, the transcriptome of the malaria parasite Plasmodium gallinaceum was characterized to investigate the biology and the conservation of genes across various malaria parasite species. The P. gallinaceum transcriptome was annotated and KEGG pathway mapping was performed. The ripr gene and orthologous genes that play critical roles in the purine salvage pathway were identified and characterized using bioinformatics and phylogenetic methods. Analysis of the transcriptome sequence database identified essential genes of the purine salvage pathway in P. gallinaceum that shared high sequence similarity to Plasmodium falciparum when compared to other mammalian Plasmodium spp. However, based on the current sequence data, there was a lack of orthologous genes that belonged to the erythrocyte-binding-like (EBL) and reticulocyte-binding-like homologue (RH) family in P. gallinaceum. In addition, an orthologue of the Rh5 interacting protein (ripr) was identified. These findings suggest that the pathways involved in parasite red blood cell invasion are significantly different in avian Plasmodium parasites, but critical metabolic pathways are conserved throughout divergent Plasmodium taxa.

  9. IN MEMORIAM DOCTOR DIRK FOK VAN SLOOTEN

    Directory of Open Access Journals (Sweden)

    DIRK FOK VAN SLOOTEN

    2015-11-01

    Full Text Available In the midst of his work Van Slooten has been suddenly called awayat the relatively early age of 61. It was known that his heart was not toogood, but it was expected that living a quiet life he would be able to finishhis life's work, the monograph of the Malaysian Dipterocarpaceae, towhich he had been able since 1951 to devote all his time and concentrationundisturbed by other duties. The striving towards the completion of thiswork on the most important family of Malaysian forest trees alwaysoccupied his mind and had been to a large extent the main object of his life.Van Slooten's ambition was to produce careful work, meticulous inall details. This made him a slow worker, but at the same time one of thetrustworthy kind. This trend towards perfectionism expressed itselfequally in the preliminaries and routine work towards his objective.Through his method of working progress was steady but unfortunatelyrelatively slow. Other factors beyond his control added to this result.Besides delays due to World War II, Van Slooten performed many otherofficial duties in the same earnest way in which he carried out hisresearch work. Any spontaneity and opportunism he had in his characterwas suppressed through his orderliness. Only in exceptional and veryurgent circumstances would he make decisions a l'improviste. It is ofcourse questionable whether one can deduce a man's character from hispublished writings. Whether this thesis be accepted as a generality or not,it is certain that it held for Van Slooten. His care for details, for straight-forwardness, for trying to find the truth in his work found a remarkableparallel in his office work, and his private life. He wanted things to beclean and orderly. Even on excursions, which he made surprisingly seldom,his clothes were as speckless as they could possibly be in the circumstances.

  10. Keskklassi meistrivõistlused / Wolfgang König, Dirk Branke

    Index Scriptorium Estoniae

    König, Wolfgang

    2012-01-01

    Suur test. Mõõtu võtavad 15 pereautot: Audi A4 2.0 TDI, BMW 318d, Mercedes-Benz C 200 CDI, Škoda Superb 2.0 TDI, VW Passat 2.0 TDI, Citroën C5 HDi 140, Hyundai i40 1.7 CRDi, Ford Mondeo 2.0 TDCi, Kia Optima 1.7 CRDi, Mazda 6 2.2 MZR-CD, Opel Insignia 2.0 CDTI, Renault Laguna dCi 150, Peugeot 508 HDi 140, Volvo S60 D3, Seat Exeo 2.0 TDI

  11. Keskklassi meistrivõistlused / Wolfgang König, Dirk Branke

    Index Scriptorium Estoniae

    König, Wolfgang

    2012-01-01

    Suur test. Mõõtu võtavad 15 pereautot: Audi A4 2.0 TDI, BMW 318d, Mercedes-Benz C 200 CDI, Škoda Superb 2.0 TDI, VW Passat 2.0 TDI, Citroën C5 HDi 140, Hyundai i40 1.7 CRDi, Ford Mondeo 2.0 TDCi, Kia Optima 1.7 CRDi, Mazda 6 2.2 MZR-CD, Opel Insignia 2.0 CDTI, Renault Laguna dCi 150, Peugeot 508 HDi 140, Volvo S60 D3, Seat Exeo 2.0 TDI

  12. Claudio Gigante - Dirk Vanden Berghe (eds., Il romanzo del Risorgimento

    Directory of Open Access Journals (Sweden)

    Marina Polacco

    2014-05-01

    Full Text Available A  lungo il dibattito storiografico sul Risorgimento è stato dominato dalla contrapposizione tra la retorica patriottica (la celebrazione della nascita della patria, il culto dei martiri e degli eroi risorgimentali e la denuncia dei limiti e delle inadempienze del processo di unificazione (la critica del Risorgimento come rivoluzione mancata, il riconoscimento della sostanziale immobilità delle strutture di potere, la questione meridionale. Parallelamente, in campo specificamente letterario il filone d’indagine più praticato è stato quello relativo alla narrativa ‘antirisorgimentale’ – sulla scia della celebre definizione di ‘romanzo antistorico’ coniata da Spinazzola a proposito di tre testi fondamentali nella rappresentazione del periodo storico in questione (e cioè I Vicerè, I vecchi e i giovani e Il gattopardo.

  13. 新世纪中国文化研究如何三面应战--德克·卜德晚年讲稿的启示%How the Research of Chinese Culture in the New Century Will Meet Challenges from Three Aspects--The Inspiration of Sinologist Dirk Bodde ’s Lecture Note

    Institute of Scientific and Technical Information of China (English)

    李浩

    2016-01-01

    21世纪的中国文化研究面临着来自学术史、历史文献和国际学界三方面的挑战,美国著名汉学家德克·卜德晚年讲稿——《What and Why in Chinese Civilization》的洞见与不见给我们正反两方面的启示:面对空前庞大的历史文献和学术资源,研究者应勇于重审、反思那些看似不证自明的“常识”,质疑“预设”、“基础”、“前提”的合理性,重访以往被忽略的多元面相,以不断更新、丰富我们对重大文化命题的认知;研究者在利用古典文献时应充分注意到其不断附益、流变、生成和经典化、谱系化的建构过程,以确保举证、持论的科学性;国内学界应当熟悉海外汉学家的研究视野、角度、路径与方法,但必须同时注意其“解构”与“颠覆”倾向,警惕那些有意无意的偏见和误读可能带来的不良影响。%The research work of Chinese culture in the 21st century is facing challenges from three aspects:academ⁃ic history ,historical literature ,and the international academia. The insight and overlooking of“What and Why in Chi⁃nese Civilization”,the lecture note by well-known American Sinologist Dirk Bodde ,give us both positive and negative inspirations:confronted with unprecedentedcolossal historical literature and academic resources ,researchers should have the courage to reexamine and reflect on those seemingly self-evident“common sense”,challenge the rationality of the so-called“presuppositions”,“basis”,and“preconditions ,recheck the multiple facets that were ignored in the past , and constantly renew and enrich their recognition of important cultural hypothesis;when utilizing classic literature ,they should pay full attention to the constructive process ofits adjunction ,rheological deformation ,generation ,classiciza⁃tion ,and filiationso as to ensure that their adduction of proof and presentation of argument are scientific

  14. Isolation and optimization of camelid single-domain antibodies:Dirk Saerens’work on nanobodies

    Institute of Scientific and Technical Information of China (English)

    Dirk; Saerens

    2010-01-01

    It is well established that all camelids have unique antibodies circulating in their blood.Unlike antibodies from all other species,these special antibodies are devoid of light chains,and are composed of a heavy chain homodimer.These so-called heavy-chain antibodies(HCAbs)are expressed after a V-D-J rearrangement and require dedicated constant gamma genes. An immune response is raised in these HCAbs following a classical immunization protocol.These HCAbs are easily purified from serum,and their antigen-binding fragment interacts with parts of the target that are less antigenic to conventional antibodies.The antigen binding site of the dromedary HCAb comprises one single domain,referred to as VHH or nanobody(Nb),therefore,a strategy was designed to clone the Nb repertoire of an immunized dromedary and to select the Nb with specificity for our target antigens.The monoclonal Nb is produced well in bacteria,is very stable and highly soluble,and it binds the antigen with high affinity and specificity.Currently,the recombinant Nb has been developed successfully for research purposes, as a probe in biosensors,to diagnose infections,or to treat diseases such as cancer or trypanosomiasis.

  15. Issues in Conflict Resolution by Dirk Kotzé Abstract With regard to ...

    African Journals Online (AJOL)

    ... resolution initiatives in the Balkan, Middle East, Latin America or South Asia .... At the height of the internal war between the ..... (Situations where international war crimes tribunals are used or where ..... Cold War dynamics or globalisation.

  16. Venemaa on meie enda loodud oht / Noam Chomsky ; interv. Dirk Hoyer

    Index Scriptorium Estoniae

    Chomsky, Noam, 1928-

    2008-01-01

    Ühendriikide tuntud arvamusliider sõna- ja ajakirjandusvabadusest USA-s, suhtumisest Iraagi sõtta, avalikkussuhete tööstuse ja parteide juhtkondade toodete müügist presidendivalimiste kampaania käigus, tervishoiusüsteemi katastroofilisest olukorrast USA-s, valikust presidendikandidaatide Barack Obama ja John McCaini vahel, kosmose militariseerimisest, suhtumisest 11. septembrisse, Venemaast Balti julgeoleku ohuna, NATOst julgeoleku garanteerijana, energiaressurssidest kui hirmutamisvahenditest

  17. Venemaa on meie enda loodud oht / Noam Chomsky ; interv. Dirk Hoyer

    Index Scriptorium Estoniae

    Chomsky, Noam, 1928-

    2008-01-01

    Ühendriikide tuntud arvamusliider sõna- ja ajakirjandusvabadusest USA-s, suhtumisest Iraagi sõtta, avalikkussuhete tööstuse ja parteide juhtkondade toodete müügist presidendivalimiste kampaania käigus, tervishoiusüsteemi katastroofilisest olukorrast USA-s, valikust presidendikandidaatide Barack Obama ja John McCaini vahel, kosmose militariseerimisest, suhtumisest 11. septembrisse, Venemaast Balti julgeoleku ohuna, NATOst julgeoleku garanteerijana, energiaressurssidest kui hirmutamisvahenditest

  18. Regstellende aksie, aliënasie en die nie-aangewese groep / Dirk Johannes Hermann

    OpenAIRE

    2006-01-01

    Affirmative action is a central concept in South African politics and the workplace. The Employment Equity Act divides society into a designated group (blacks, women and people with disabilities) and a non-designated group (white men and white women). In this study, the influence of affirmative action on alienation of the non-designated group was investigated. Guidelines were also developed for employers in order to lead the non-designated group from a state of alienation to th...

  19. Both Islam and Christianity Invite to Tolerance: A Commentary on Dirk Baier.

    Science.gov (United States)

    Salamati, Payman; Naji, Zohrehsadat; Koutlaki, Sofia A; Rahimi-Movaghar, Vafa

    2015-12-01

    Baier recently published an interesting original article in the Journal of Interpersonal Violence. He compared violent behavior (VB) between Christians and Muslims and concluded that religiosity was not a protecting factor against violence and that Muslim religiosity associated positively with increased VB. We appreciate the author's enormous efforts on researching such an issue of relevance to today's world. However, in our view, the article has methodological weaknesses in terms of participants, instruments, and statistical analyses, which we examine in detail. Therefore, Baier's results should be interpreted more cautiously. Although interpersonal violence may sometimes be observable among Muslims, we do not attribute these to Islam's teachings. In our opinion, both Islam and Christianity invite to tolerance, peace, and friendship. So, the comparison of such differences and the drawing of conclusions that may reflect negatively on specific religious groups need better defined research, taking into consideration other basic variables in different communities.

  20. The Hughes Court and Radical Dissent: The Case of Dirk De Jonge and Angelo Herndon

    OpenAIRE

    Tushnet, Mark V.

    2012-01-01

    Scattered Supreme Court decisions in the early twentieth century dealt with the Constitution’s protection of freedom of speech. Radical dissent over United States participation in World War I and the nation’s intervention against the Bolshevik revolution in Russia led the Court to its first sustained engagement with free speech cases. By the time Chief Justice Hughes took the center chair, the national government largely had abandoned its pursuit of radical dissenters, some of whom played la...

  1. Dirk Lüddecke, Felicia Englmann (Hrsg.): Das Staatsverständnis Ernst Cassirers, Nomos Verlag, 2015

    DEFF Research Database (Denmark)

    Pedersen, Esther Oluffa

    2015-01-01

    Review of the anthology "Das Staatsverständnis Ernst Cassirers" - a collection of articles dealing with Cassirer as a political philosopher.......Review of the anthology "Das Staatsverständnis Ernst Cassirers" - a collection of articles dealing with Cassirer as a political philosopher....

  2. Experience based learning (EBL): Exploring professional teaching through critical reflection and reflexivity.

    Science.gov (United States)

    Murphy, Fiona; Timmins, Fiona

    2009-01-01

    Utilising Rolfe's [Rolfe, G., 1998. Expanding Nursing Knowledge: Understanding and Researching Your Own Practice. Butterworth-Heinemann, Oxford] reflexive action research, one novice nurse educator explored current teaching practice. The data were collected from a reflective journal and colleague feedback. Through this data collection and applying Rolfe's (1998) understanding-action-evaluation (UAE) cycle an insight was gained within the community of practice regarding teaching methods. Didactic lecture methods were found to be the preferred option, arising from lack of confidence. Through personal reflection and sharing with colleagues overall teaching practice improved. It is suggested that models of reflective practice that focus on work based learning, rather than the individual are utilised within nurse education settings to develop localised theory and support novice teachers. Models of reflection and action research may be used within these frameworks to extrapolate in depth reflections as a basis for theory development.

  3. Surface enhanced Raman spectroscopy detection of biomolecules using EBL fabricated nanostructured substrates.

    Science.gov (United States)

    Peters, Robert F; Gutierrez-Rivera, Luis; Dew, Steven K; Stepanova, Maria

    2015-03-20

    Fabrication and characterization of conjugate nano-biological systems interfacing metallic nanostructures on solid supports with immobilized biomolecules is reported. The entire sequence of relevant experimental steps is described, involving the fabrication of nanostructured substrates using electron beam lithography, immobilization of biomolecules on the substrates, and their characterization utilizing surface-enhanced Raman spectroscopy (SERS). Three different designs of nano-biological systems are employed, including protein A, glucose binding protein, and a dopamine binding DNA aptamer. In the latter two cases, the binding of respective ligands, D-glucose and dopamine, is also included. The three kinds of biomolecules are immobilized on nanostructured substrates by different methods, and the results of SERS imaging are reported. The capabilities of SERS to detect vibrational modes from surface-immobilized proteins, as well as to capture the protein-ligand and aptamer-ligand binding are demonstrated. The results also illustrate the influence of the surface nanostructure geometry, biomolecules immobilization strategy, Raman activity of the molecules and presence or absence of the ligand binding on the SERS spectra acquired.

  4. Evaluation of Antimicrobial Activity of Glucose Oxidase from Aspergillus niger EBL-A and Penicillium notatum

    Directory of Open Access Journals (Sweden)

    Muhammad Anjum Zia

    2013-12-01

    Full Text Available This work aimed to study the production and purification of glucose oxidase by Aspergillus niger and Penicillium notatum using corn steep liquor as the substrate and evaluate its antimicrobial activity for use in pharmaceutical and food industries. The enzyme was purified by ammonium sulfate precipitation (60-85%, DEAE-cellulose ion exchange and Sephadex G-200 size exclusion chromatography. The crude enzyme extracts of A. niger and P. notatum showed 2.32 and 5.53 U mg-1 specific activities, respectively, which after desalting was 15.52 and 12.05 U mg-1, and after ion exchange and gel filtration chromatography was 29.09 - 62 and 25.72 - 59.37 U mg-1 for A. niger and P. notatum, respectively. The antimicrobial activity was determined by disc diffusion method against selected microbial strains where glucose oxidase from A. niger showed anti-bacterial activity, while no fungicidal effects were shown by both A. niger and P. notatum glucose oxidases.

  5. Supporting learning in practice in the EBL curriculum: pre-registration students' access to learning resources in the placement setting.

    Science.gov (United States)

    Walton, Graham; Smith, Ann; Gannon-Leary, Pat; Middleton, Anne

    2005-07-01

    This paper explores access to learning resources for nursing students when on placement. It also examines, in parallel, the impact of the move to enquiry based learning has on learning resources use by nursing students. The increased time spent learning in the clinical setting means that a deeper understanding of the use of learning resources by nursing students is necessary. A questionnaire survey was completed by 247 nursing students at Northumbria University around their use of learning resources on placement. This corresponded with focus groups being run with University and NHS providers of learning resources to establish the impact of enquiry based learning. It was found that effective collaboration between different stakeholders was especially important. Nursing students are also becoming increasingly sophisticated in their use of electronic learning resources. The nature of support for effective learning resources use by nursing students whilst on placement in the NHS has also been identified as key. The work has shown that it is very difficult to establish the impact of enquiry based learning on learning resources, as there are so many other variables.

  6. Review: Dirk Tänzler, Hubert Knobloch & Hans-Georg Soeffner (Eds. (2006. Neue Perspektiven der Wissenssoziologie [New Perspectives on the Sociology of Knowledge

    Directory of Open Access Journals (Sweden)

    Torsten Junge

    2008-10-01

    Full Text Available The 14 articles in this collection present theories, questions and research areas in German sociology of knowledge. The contributions analyze the construction of reality with regard to knowledge. As a science of "the real," sociology of knowledge gains access to other disciplines such as ethnology, systems theory, communication studies or cognitive science. The collection emphasizes a critical approach to the possibilities and capacities of sociology of knowledge as such. URN: urn:nbn:de:0114-fqs0901278

  7. Biotronics

    Science.gov (United States)

    2012-11-01

    79 55 Current density vs. voltage in green Alq3 LEDs: baseline device, DNA EBL , PVK EBL , PMMA EBL . Inset shows a simple equivalent...circuit for the DNA EBL device...80 56 Luminous efficiency vs. luminance in Alq3 EL devices: baseline device, DNA EBL , PVK EBL , PMMA EBL

  8. New constraints on the Mid-IR EBL from the HESS discovery of VHE gamma rays from 1ES 0229+200

    CERN Document Server

    Aharonian, F; Bazer-Bachi, A R; Behera, B; Beilicke, M; Benbow, W; Bernlöhr, K; Boisson, C; Bolz, O; Borrel, V; Braun, I; Brion, E; Brown, A M; Buhler, R; Bulik, T; Büsching, I; Boutelier, T; Carrigan, S; Chadwick, P M; Chounet, L M; Clapson, A C; Coignet, G; Cornils, R; Costamante, L; Dalton, M; Degrange, B; Dickinson, H J; Djannati-Atai, A; Domainko, W; O'Connor-Drury, L; Dubois, F; Dubus, G; Dyks, J; Egberts, K; Emmanoulopoulos, D; Espigat, P; Farnier, C; Feinstein, F; Fiasson, A; Förster, A; Fontaine, G; Funk, Seb; Fussling, M; Gallant, Y A; Giebels, B; Glicenstein, J F; Glück, B; Goret, P; Hadjichristidis, C; Hauser, D; Hauser, M; Heinzelmann, G; Henri, G; Hermann, G; Hinton, J A; Hoffmann, A; Hofmann, W; Holleran, M; Hoppe, S; Horns, D; Jacholkowska, A; De Jager, O C; Jung, I; Katarzynski, K; Kendziorra, E; Kerschhaggl, M; Khelifi, B; Keogh, D; Komin, Nu; Kosack, K; Lamanna, G; Latham, I J; Lemiere, A; Lemoine-Goumard, M; Lenain, J P; Lohse, T; Martin, J M; Martineau-Huynh, O; Marcowith, A; Masterson, C; Maurin, D; Maurin, G; McComb, T J L; Moderski, R; Moulin, E; De Naurois, Mathieu; Nedbal, D; Nolan, S J; Ohm, S; Olive, J P; de Ona Wilhelmi, E; Orford, K J; Osborne, J L; Ostrowski, M; Panter, M; Pedaletti, G; Pelletier, G; Petrucci, P O; Pita, S; Pühlhofer, G; Punch, M; Ranchon, S; Raubenheimer, B C; Raue, M; Rayner, S M; Renaud, M; Ripken, J; Rob, L; Rolland, L; Rosier-Lees, S; Rowell, G; Rudak, B; Ruppel, J; Sahakian, V V; Santangelo, A; Schlickeiser, R; Schock, F; Schroder, R; Schwanke, U; Schwarzburg, S; Schwemmer, S; Shalchi, A; Sol, H; Spangler, D; Stawarz, L; Steenkamp, R; Stegmann, C; Superina, G; Tam, P H; Tavernet, J P; Terrier, R; Van Eldik, C; Vasileiadis, G; Venter, C; Vialle, J P; Vincent, P; Vivier, M; Völk, H J; Volpe, F; Wagner, S J; Ward, M; Zdziarski, A A; Zech, A

    2007-01-01

    AIMS: To investigate the very high energy (VHE: >100 GeV) gamma-ray emission from the high-frequency peaked BL Lac 1ES 0229+200. METHODS: Observations of 1ES 0229+200 at energies above 580 GeV were performed with the High Energy Stereoscopic System (HESS) in 2005 and 2006. RESULTS: 1ES 0229+200 is discovered by HESS to be an emitter of VHE photons. A signal is detected at the 6.6 sigma level in the HESS observations (41.8 h live time). The integral flux above 580 GeV is (9.4 +- 1.5 {stat} +- 1.9 {syst}) x 10^{-13} cm^{-2} s^{-1}, corresponding to ~1.8% of the flux observed from the Crab Nebula. The data show no evidence for significant variability on any time scale. The observed spectrum is characterized by a hard power law (Gamma = 2.50 +- 0.19 {stat} +- 0.10 {syst}) from 500 GeV to ~15 TeV. CONCLUSIONS: The high-energy range and hardness of the observed spectrum, coupled with the object's relatively large redshift (z=0.1396), enable the strongest constraints so far on the density of the Extragalactic Backgr...

  9. Book Review: Is Fair Value Fair? Financial Reporting from an International Perspective

    DEFF Research Database (Denmark)

    Thinggaard, Frank

    2005-01-01

    This is a review of Henk Langendijk, Dirk Swagerman and Willem Verhoog (Eds) "Is Fair Value Fair? Financial Reporting from an International Perspective," Chichester: John Wiley, 2003, ISBN 0 470 85028 0.......This is a review of Henk Langendijk, Dirk Swagerman and Willem Verhoog (Eds) "Is Fair Value Fair? Financial Reporting from an International Perspective," Chichester: John Wiley, 2003, ISBN 0 470 85028 0....

  10. Stemcell Information: SKIP001187 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available ter Dirks et al. Steven M. Pollard, ... Peter Dirks et al. Arthur and Sonia Labatt B...rain Tumor Research Center, Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, University of Toronto Art...hur and Sonia Labatt Brain Tumor Research Center, Program in Developmental and Stem

  11. SPARKy-Spring Ankle with Regenerative Kinematics

    Science.gov (United States)

    2011-09-01

    at the Literati Network Awards for Excellence 2010. 3. Ronald Van Ham, Thomas G. Sugar, Bram Vanderborght, Kevin W. Hollander, Dirk Lefeber...Ronald Van Ham, Thomas G. Sugar, Bram Vanderborght, Kevin W. Hollander, Dirk Lefeber, “Compliant Actuator Designs: Review of Actuators with Passive

  12. Propranolol associated with endoscopic band ligation reduces recurrence of esophageal varices for primary prophylaxis of variceal bleeding: a randomized-controlled trial.

    Science.gov (United States)

    Bonilha, Danielle Queiroz; Lenz, Luciano; Correia, Lucianna Motta; Rodrigues, Rodrigo Azevedo; de Paulo, Gustavo Andrade; Ferrari, Angelo Paulo; Della Libera, Ermelindo

    2015-01-01

    The aim of this study was to compare the recurrence of esophageal varices (EVs) after endoscopic band ligation (EBL) associated with propranolol (PP) versus EBL alone. Sixty-six cirrhotic outpatients (EBL group, n=32 and EBL+PP group, n=34) with high-risk EVs without previous bleeding were studied. The primary outcome was recurrence of EV. The secondary outcomes were EV eradication, bleeding before EV eradication, mortality, and adverse events. Demographic characteristics and the initial endoscopic findings were similar. EV eradication was achieved in all patients. Three patients presented gastrointestinal bleeding before variceal eradication, two in the EBL group and one in the EBL+PP group (P=0.13). Six patients died (liver failure), two in the EBL group and four in the EBL+PP group (P=0.27). Twelve (38%) patients in the EBL group and three (9%) patients in the EBL+PP group had variceal recurrence. The risk of recurrence of EVs after eradication was significantly higher among patients in the EBL group (P=0.003). EBL alone and EBL+PP were effective in the primary prophylaxis of bleeding from EVs in cirrhotic patients (EV eradication, bleeding before EV eradication, mortality, and adverse events were similar in both groups). However, variceal recurrence was lower in the EBL+PP group than band ligation alone.

  13. Preoperative predictors of blood loss at the time of radical prostatectomy: results from the SEARCH database.

    Science.gov (United States)

    Lloyd, J C; Bañez, L L; Aronson, W J; Terris, M K; Presti, J C; Amling, C L; Kane, C J; Freedland, S J

    2009-01-01

    The literature contains conflicting data on preoperative predictors of estimated blood loss (EBL) at radical retropubic prostatectomy (RRP). We sought to examine preoperative predictors of EBL at the time of RRP among patients from the SEARCH database to lend clarity to this issue. A total of 1154 patients were identified in the SEARCH database who underwent RRP between 1988 and 2008 and had EBL data available. We examined multiple preoperative factors for their ability to predict EBL using multivariate linear regression analysis. Median EBL was 900 ml (s.d. 1032). The 25th and 75th percentile for EBL were 600 and 1500 ml, respectively. EBL increased significantly with increasing body mass index (BMI) and increasing prostate size and decreased with more recent year of RRP (all PEBL in normal-weight men (BMIor=35 kg/m(2)). Predicted EBL for men with the smallest prostates (or=100 g. Finally, statistically significant differences between centers were observed, with mean-adjusted EBL ranging from 844 to 1094 ml. Both BMI and prostate size are predictors of increased EBL. Prostate size is of particular note, as a nearly twofold increased EBL was seen from the smallest (or=100 g). Over time, average EBL significantly decreased. Finally, significant differences in EBL were observed between centers. Patients with multiple risk factors should be forewarned they are at increased risk for higher EBL, which may translate into a greater need for blood transfusion.

  14. Is it safe to perform endoscopic band ligation for the duodenum? A pilot study in ex vivo porcine models.

    Science.gov (United States)

    Kakutani, Hiroshi; Sasaki, Shigemasa; Ueda, Kaoru; Takakura, Kazuki; Sumiyama, Kazuki; Imazu, Hiroo; Hino, Syoryoku; Kawamura, Muneo; Tajiri, Hisao

    2013-04-01

    In the digestive tract, endoscopic band ligation (EBL) has been routinely used for the treatment of variceal bleeding and superficial malignancies. In recent years, endoscopic treatments for duodenal varices, adenoma, and cancer have also actively incorporated EBL. Although there have been a number of reports on the risks associated with the use of EBL in the esophagus, stomach, and colon, few studies have focused on EBL in the duodenum. We performed EBL procedures to evaluate the risks associated with the use of EBL in the duodenum. Overall, EBLs were performed at nine sites in duodenum sampled from a pig immediately after sacrifice. Submucosal saline injections were placed in three of the nine studied sites. Regardless of saline injection, the full thickness of the duodenal wall was ligated in all attempts. Routine EBL is not recommended in the duodenum because the risk of perforation is unacceptably high.

  15. Endoscopic band ligation for colonic diverticular bleeding: possibility of standardization

    OpenAIRE

    Shimamura, Yuto; Ishii, Naoki; Omata, Fumio; Imamura, Noriatsu; Okamoto, Takeshi; Ego, Mai; Nakano, Kaoru; Ikeya, Takashi; Nakamura, Kenji; TAKAGI, KOICHI; Fukuda, Katsuyuki; Fujita, Yoshiyuki

    2016-01-01

    Background and aims: Endoscopic band ligation (EBL) has been used to achieve hemostasis in patients with colonic diverticular bleeding. The safety and effectiveness of EBL when performed by non-expert endoscopists have not been sufficiently verified. This study aimed to elucidate the feasibility of the EBL technique when performed by non-expert endoscopists and of considering EBL as a standard treatment for colonic diverticular bleeding. Patients and methods: A retrospective cohort study was ...

  16. Assoziation des arteriellen Sauerstoffpartialdrucks mit dem Auftreten von Erythroblasten im peripheren Blut von Patienten einer chirurgischen Intensivstation

    OpenAIRE

    Kuert, Sandra

    2012-01-01

    Erythroblasten (EBL) treten im peripheren Blut eines gesunden Erwachsenen gewöhnlich nicht auf. Studien zeigten, dass das Auftreten von EBL bei hospitalisierten Patienten auf ein erhöhtes Mortalitätsrisiko hinweist. Die zugrundeliegenden Mechanismen sind bisher unbekannt. Es ergaben sich Hinweise, dass EBL bei Zuständen von Hypoxie und Inflammation auftreten. Die vorliegende Studie untersucht den Einfluss des arteriellen Sauerstoffpartialdruckes (pO2) auf das Auftreten von EBL ...

  17. Identification of an Atypical Enzootic Bovine Leukosis in Japan by Using a Novel Classification of Bovine Leukemia Based on Immunophenotypic Analysis.

    Science.gov (United States)

    Nishimori, Asami; Konnai, Satoru; Okagawa, Tomohiro; Maekawa, Naoya; Goto, Shinya; Ikebuchi, Ryoyo; Nakahara, Ayako; Chiba, Yuzumi; Ikeda, Masaho; Murata, Shiro; Ohashi, Kazuhiko

    2017-09-01

    Bovine leukemia is classified into two types: enzootic bovine leukosis (EBL) and sporadic bovine leukosis (SBL). EBL is caused by infection with bovine leukemia virus (BLV), which induces persistent lymphocytosis and B-cell lymphoma in cattle after a long latent period. Although it has been demonstrated that BLV-associated lymphoma occurs predominantly in adult cattle of >3 to 5 years, suspicious cases of EBL onset in juvenile cattle were recently reported in Japan. To investigate the current status of bovine leukemia in Japan, we performed immunophenotypic analysis of samples from 50 cattle that were clinically diagnosed as having bovine leukemia. We classified the samples into five groups on the basis of the analysis and found two different types of EBL: classic EBL (cEBL), which has the familiar phenotype commonly known as EBL, and polyclonal EBL (pEBL), which exhibited neoplastic proliferation of polyclonal B cells. Moreover, there were several atypical EBL cases even in cEBL, including an early onset of EBL in juvenile cattle. A comparison of the cell marker expressions among cEBL, pEBL, and B-cell-type SBL (B-SBL) revealed characteristic patterns in B-cell leukemia, and these patterns could be clearly differentiated from those of healthy phenotypes, whereas it was difficult to discriminate between cEBL, pEBL, and B-SBL only by the expression patterns of cell markers. This study identified novel characteristics of bovine leukemia that should contribute to a better understanding of the mechanism underlying tumor development in BLV infection. Copyright © 2017 American Society for Microbiology.

  18. The Fabrication of Arrays of Single Ions in Silicon via Ion Implantation

    Science.gov (United States)

    2014-02-01

    directly into the detector via an EBL fabricated trench. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151 5.13 nanoIBIC image of...the target chamber and under vacuum, a series of EBL defined slots in the PMMA covering the active region can be used to align the aperture to the EBL ...Each aperture was assumed to be 10 nm in diameter (state-of-the-art for EBL in PMMA), separated linearly by either 20 nm or 30 nm. 14 keV P+ reach an

  19. Computational Modeling Basis in the Photostress Recovery Model (PREMO)

    Science.gov (United States)

    2014-09-01

    13 Figure 8. The decay of the EBL after the exposure is terminated ....................................15 Figure...equivalent background luminance ( EBL ).11 In addition, both glare and photostress recovery effects depend not only on the parameters of the inducing light...combined image is known as the EBL reduced visual task image ),( yxERVT and it is given by: ),(),(),( yxVTyxEBLyxERVT += , (27) where EBL (x,y) is the

  20. Presence of European bat lyssavirus RNas in apparently healthy Rousettus aegyptiacus bats

    NARCIS (Netherlands)

    Wellenberg, G.J.; Audry, L.; Ronsholt, L.; Poel, van der W.H.M.; Bruschke, C.J.M.; Bourhy, H.

    2002-01-01

    Apparently healthy Rousettus aegyptiacus bats were randomly chosen from a Dutch colony naturally infected with European bat lyssavirus subgenotype 1a (EBL1a). These bats were euthanised three months after the first evidence of an EBL1a infection in the colony. EBL1a genomic and antigenomic RNAs of

  1. Presence of European bat lyssavirus RNas in apparently healthy Rousettus aegyptiacus bats

    NARCIS (Netherlands)

    Wellenberg, G.J.; Audry, L.; Ronsholt, L.; Poel, van der W.H.M.; Bruschke, C.J.M.; Bourhy, H.

    2002-01-01

    Apparently healthy Rousettus aegyptiacus bats were randomly chosen from a Dutch colony naturally infected with European bat lyssavirus subgenotype 1a (EBL1a). These bats were euthanised three months after the first evidence of an EBL1a infection in the colony. EBL1a genomic and antigenomic RNAs of t

  2. Integration of Female Pilots in the 160th Special Operations Aviation Regiment (Airborne) - A Culture Already Set-Up for Success

    Science.gov (United States)

    2014-02-14

    Level ( EBL ), comes closer to the core of an organization’s culture. The EBL comprises the “beliefs and ethical rules … (that) are explicitly...articulated, (and) they serve the normative… function of guiding members of the group … in training new members how to behave.” 17 The EBL is where an

  3. 40 CFR 745.227 - Work practice standards for conducting lead-based paint activities: target housing and child...

    Science.gov (United States)

    2010-07-01

    ... (EBL) determination, or Federal, State, Tribal, or local emergency abatement order should be received... showing evidence of an EBL determination or a copy of the Federal/State/Tribal/local emergency abatement.... (H) Documentation showing evidence of an EBL determination or a copy of the Federal/State/Tribal...

  4. Control of Heat and Charge Transport in Nanostructured Hybrid Materials

    Science.gov (United States)

    2015-07-21

    precludes the use of common photolithographic techniques.5 These limitations can be overcome through the use of electron-beam lithographic ( EBL ...processes. However, EBL is an expensive and serial process that limits the size of the lithographically defined region. In addition, EBL suffers from

  5. Constraining Extragalactic Background Light From TeV Blazars

    OpenAIRE

    Yang, Jianping; Wang, Jiancheng

    2010-01-01

    Our goal is to research the upper limits on the extragalactic background light (EBL). The upper limits on the extragalactic background light (EBL), using the Fermi and very high energy (VHE) spectra recently observed in TeV blazars, are presented. We use an assumption that the VHE intrinsic photon index cannot be harder than the Fermi index measured by the Fermi-LAT. Totally, these upper limits on the EBL are compatible with ones given by most of EBL models. However, the models of high EBL de...

  6. Külalisesinejate sõnavõtud

    Index Scriptorium Estoniae

    1999-01-01

    Ettekandjad: Elisabeth Arnold, Dirk van der Maelen, FranciscoTorres, JiriMashtalka, Demetrios Syllouris, Karoly Lotz, Uwe Gehlen, Michael Sahlin, Tony Gregory, Roma Dovydeniene, Janusz Lewandowski, Ekkehard Pabsch, Jelko Kacir, Jean-Jacques Subrenat, Savas Tsitouridis, Alfred E. Kellermann

  7. RNA interference in plant parasitic nematodes

    African Journals Online (AJOL)

    STORAGESEVER

    2008-08-04

    Aug 4, 2008 ... produce effective and durable forms of nematode control. Principle advantages ... Carthew, 1998, 2000) and amphibians (Dirks et al., 2003;. Li and Rohrer .... glands. Cysteine proteinase. Increased male: female ratio. Intestine.

  8. Een geschiedenis van vleesloos eten

    NARCIS (Netherlands)

    Dagevos, H.

    2009-01-01

    Recensie van de populaire editie van het proefschrift van Dirk-Jan Verdonk: Het dierloze gerecht: een vegetarische geschiedenis in Nederland. Hierin wordt de geschiedenis van het vegetarisme vanaf de tweede helft van de 19e eeuw tot nu beschreven

  9. Hamburg kui hiiglaslik ehitustander

    Index Scriptorium Estoniae

    2003-01-01

    6. novembrist Eesti Arhitektuurimuuseumis Rotermanni soolalaos näitus "arcHH - Architektur made in Hamburg", mis esitleb Hamburgi arhitektide viimase viie aasta loomingut. Näituse koostaja Dirk Meyhöfer, arhitekt Michael Karassowitch

  10. Een geschiedenis van vleesloos eten

    NARCIS (Netherlands)

    Dagevos, H.

    2009-01-01

    Recensie van de populaire editie van het proefschrift van Dirk-Jan Verdonk: Het dierloze gerecht: een vegetarische geschiedenis in Nederland. Hierin wordt de geschiedenis van het vegetarisme vanaf de tweede helft van de 19e eeuw tot nu beschreven

  11. Külalisesinejate sõnavõtud

    Index Scriptorium Estoniae

    1999-01-01

    Ettekandjad: Elisabeth Arnold, Dirk van der Maelen, FranciscoTorres, JiriMashtalka, Demetrios Syllouris, Karoly Lotz, Uwe Gehlen, Michael Sahlin, Tony Gregory, Roma Dovydeniene, Janusz Lewandowski, Ekkehard Pabsch, Jelko Kacir, Jean-Jacques Subrenat, Savas Tsitouridis, Alfred E. Kellermann

  12. Postsovkhoz / Margus Kiis

    Index Scriptorium Estoniae

    Kiis, Margus

    2004-01-01

    Mõtte- ja keskkonnakunsti talgud aastail 2001-2003 Moostes. Kommenteerivad üritustest osavõtjad Dirk Lange, Maja Linke, Natalie Waldbaum, Jaakko Himanen, Jere Ruotsalainen, Jorge Tarazona, Slobodanka Stevceska ja Denis Saraginovski

  13. Postsovkhoz / Margus Kiis

    Index Scriptorium Estoniae

    Kiis, Margus

    2004-01-01

    Mõtte- ja keskkonnakunsti talgud aastail 2001-2003 Moostes. Kommenteerivad üritustest osavõtjad Dirk Lange, Maja Linke, Natalie Waldbaum, Jaakko Himanen, Jere Ruotsalainen, Jorge Tarazona, Slobodanka Stevceska ja Denis Saraginovski

  14. Stemcell Information: SKIP001185 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available ... Steven M. Pollard, ... Peter Dirks et al. Steven M. Pollard, ... Peter Dirks et al. Arthur...pital for Sick Children, University of Toronto Arthur and Sonia Labatt Brain Tumor Research Center, Program ...in Developmental and Stem Cell Biology, The Hospital for Sick Children, University of Toronto ... Information Only Arthur...tal and Stem Cell Biology, The Hospital for Sick Children, University of Toronto Arthur and Sonia Labatt Bra

  15. Endoscopic band ligation: beyond prevention and management of gastroesophageal varices.

    Science.gov (United States)

    Ji, Jeong-Seon; Cho, Young-Seok

    2013-07-21

    Endoscopic band ligation (EBL) is the preferred endoscopic technique for the endoscopic treatment of acute esophageal variceal bleeding. EBL has also been used to treat nonvariceal bleeding. Recently, Han et al demonstrated that EBL can be a feasible and safe alternate technique for the management of iatrogenic gastric perforation especially in cases in which closure with endoclips is difficult. EBL is technically simpler to perform than other methods and provides a good view of the lesions under direct pressure and suction from the transparent ligation cap. EBL can be used even if the diameter of the perforation is greater than 10 mm or if there is a severe tangential angle. In this commentary, we discuss the efficacy and safety of EBL for the closure of iatrogenic gastrointestinal perforation. We also discuss the advantages and disadvantages of EBL for the treatment of nonvariceal bleeding.

  16. Estimated blood loss as a predictor of PSA recurrence after radical prostatectomy: results from the SEARCH database.

    Science.gov (United States)

    Lloyd, Jessica C; Bañez, Lionel L; Aronson, William J; Terris, Martha K; Presti, Joseph C; Amling, Christopher L; Kane, Christopher J; Freedland, Stephen J

    2010-02-01

    Diagnosis (exploratory cohort). 2b. To clarify the relationship between estimated blood loss (EBL) and biochemical recurrence, assessed by prostate-specific antigen (PSA) level, as blood loss is a long-standing concern associated with radical prostatectomy (RP), and no studies to date have examined the association between blood loss and cancer control. In all, 1077 patients were identified in the Shared Equal-Access Regional Cancer Hospital database who underwent retropubic RP (between 1998 and 2008) and had EBL and follow-up data available. We examined the relationship between EBL and recurrence using multivariate Cox regression analyses. Increased EBL was correlated with PSA recurrence in a multivariate-adjusted model (P = 0.01). When analysed by 500-mL EBL categories, those with an EBL of EBL of 1500-3499 mL, before decreasing again for patients with an EBL of > or =3500 mL. Men with an EBL of 2500-3499 mL had more than twice the risk of recurrence than men with an EBL of EBL was not associated with adverse tumour stage, grade or margin status. There was a significant correlation between EBL at the time of RP and biochemical recurrence. We hypothesized that this association might be due to transfusion-related immunosuppression, excessive blood obscuring the operative field, EBL being a marker of aggressive disease, or EBL being a marker of poor surgical technique. However, our data did not completely fit any one of these hypotheses, and thus the ultimate cause for the increased risk of recurrence remains unclear and requires further study.

  17. Structuring of turbulence and its impact on basic features of Ekman boundary layers

    Directory of Open Access Journals (Sweden)

    I. Esau

    2013-08-01

    Full Text Available The turbulent Ekman boundary layer (EBL has been studied in a large number of theoretical, laboratory and modeling works since F. Nansen's observations during the Norwegian Polar Expedition 1893–1896. Nevertheless, the proposed analytical models, analysis of the EBL instabilities, and turbulence-resolving numerical simulations are not fully consistent. In particular, the role of turbulence self-organization into longitudinal roll vortices in the EBL and its dependence on the meridional component of the Coriolis force remain unclear. A new set of large-eddy simulations (LES are presented in this study. LES were performed for eight different latitudes (from 1° N to 90° N in the domain spanning 144 km in the meridional direction. Geostrophic winds from the west and from the east were used to drive the development of EBL turbulence. The emergence and growth of longitudinal rolls in the EBL was simulated. The simulated rolls are in good agreement with EBL stability analysis given in Dubos et al. (2008. The destruction of rolls in the westerly flow at low latitude was observed in simulations, which agrees well with the action of secondary instability on the rolls in the EBL. This study quantifies the effect of the meridional component of the Coriolis force and the effect of rolls in the EBL on the internal EBL parameters such as friction velocity, cross-isobaric angle, parameters of the EBL depth and resistance laws. A large impact of the roll development or destruction is found. The depth of the EBL in the westerly flow is about five times less than it is in the easterly flow at low latitudes. The EBL parameters, which depend on the depth, also exhibit large difference in these two types of the EBL. Thus, this study supports the need to include the horizontal component of the Coriolis force into theoretical constructions and parameterizations of the boundary layer in models.

  18. Near infrared organic photodetector utilizing a double electron blocking layer.

    Science.gov (United States)

    Shafian, Shafidah; Hwang, Heewon; Kim, Kyungkon

    2016-10-31

    A near infrared organic photodiode (OPD) utilizing a double electron blocking layer (EBL) fabricated by the sequential deposition of molybdenum (VI) oxide (MoO3) and poly(3,4ethylenedioxythiophene):poly(styrene-sulfonate) (PEDOT:PSS) is reported. The double EBL improves the on/off current ratio of OPD up to 1.36 x 104 at -1V, which is one order of magnitude higher than PEDOT:PSS single EBL (2.45 x 103) and three orders of magnitude higher than that of MoO3 single EBL (7.86). The detectivity at near infrared (800 nm) at -1V is 4.90 x 1011 Jones, which is 2.83 times higher than the PEDOT:PSS single EBL and 2 magnitudes higher compared to the MoO3 single EBL.

  19. Porous and Phase Change Nanomaterials For Photonic Applications

    Science.gov (United States)

    2014-08-28

    application of traditional lithography strategies (e.g. electron-beam lithography ( EBL ) and photolithography, fol- lowed or proceeded by etching), such...precisely and arbitrarily tailored at the sur- face of a chip. Primary examples of GSL include gray-scale variants of electron-beam lithography ( EBL ...100) wafers by gray-scale electron-beam lithography ( EBL ) followed by anisotropic reactive ion etching (RIE), un- less otherwise noted. Two different

  20. Silicon Quantum Dots for Quantum Information Processing

    Science.gov (United States)

    2013-11-01

    NeillConcelman CNOT Controlled-not gate CPU Central processing unit DC Direct current DCE dichloroethylene EBL Electron beam lithography ESR Electron spin...Electron Beam Lithography of Gates and Alignment Markers The main electron beam lithography ( EBL ) machine used for fabricating the devices in this thesis...vided additional support for patterning parameters such as drawing sequences, drawing directions and area dose, and controlling the EBL writing

  1. Self-Assembly of Large-Scale Shape-Controlled DNA Nano-Structures

    Science.gov (United States)

    2014-12-16

    graphene nanostructures with specific spatial dimensions remains a significant challenge. For example, electron beam lithography ( EBL ) can be used for...Compared with traditional approaches, such as EBL , using DNA nanostructures as templates to achieve diverse shaped conductive materials has some key...produced by DNA-tempIated lithography, with ~40nm inner diameter and ~20nm width, cannot be easily reproduced using EBL . Moreover, because this is

  2. Evaluations of the Combat Ready Clamp to Control Bleeding in Human Cadavers, Manikins, Swine Femoral Artery Hemorrhage Model and Swine Carcasses

    Science.gov (United States)

    2012-06-01

    time to stop hemorrhage, in seconds). 2. Estimated blood loss ( EBL ) in milliliters. 25 3. Safety measures: a) correct assembly (yes or no); b) clip...Estimated blood loss ( EBL ) recovered from manikin drainage was measured in milliliters. 27 Assessment of assembly: all steps must have been successfully...represent median values for each user. Estimated blood loss ( EBL ) averaged 581 ± 148 ml (range 400 to 1150 ml). Time to hemorrhage control correlated

  3. Interleukin-6 and Interleukin-10 Gene Promoter Polymorphisms and Risk of Endemic Burkitt Lymphoma

    OpenAIRE

    Oduor, Cliff I.; Chelimo, Kiprotich; Ouma, Collins; Mulama, David H.; Foley, Joslyn; Vulule, John; Bailey, Jeffrey A.; Moormann, Ann M.

    2014-01-01

    Overexpression of interleukin-6 (IL-6) and IL-10 in endemic Burkitt lymphoma (eBL) may facilitate tumorigenesis by providing a permissive cytokine milieu. Promoter polymorphisms influence interindividual differences in cytokine production. We hypothesized that children genetically predisposed for elevated cytokine levels may be more susceptible to eBL. Using case-control samples from western Kenya consisting of 117 eBL cases and 88 ethnically matched healthy controls, we tested for the associ...

  4. PECASE: New Directions for Silicon Integrated Optics

    Science.gov (United States)

    2013-04-30

    passive silicon photonic components by direct-write electron beam lithography ( EBL ). Using waveguide transmission loss as a metric, we study the...impact of EBL writing parameters on waveguide performance and writing time. As expected, write strategies that reduce sidewall roughness improve waveguide...writing using the smaller field-size option of our EBL system. The authors quantify the improvement for each variation and option, along with the

  5. Research and Education in Development of Multifunctional Sensors and MEMS Devices

    Science.gov (United States)

    2015-07-15

    electron beam lithography ( EBL ), photolithography, surface b. ABSTRACT 2. REPORT TYPE 17. LIMITATION OF ABSTRACT 15. NUMBER OF PAGES 5d. PROJECT...deposited (ALD) AZO films using electron beam lithography ( EBL ). We have annealed the ALD grown samples at several temperatures to control the...nanopatterning of AZO by the EBL technique is limited and controlled by the granularity of ALD grown AZO films, and could be improved by post annealing. In

  6. Patterns of Care, Utilization, and Outcomes of Treatments for Localized Prostate Cancer

    Science.gov (United States)

    2013-09-01

    understanding of the complex orsal venous anatomy, and ability to limit excessive bleed- ng. Estimated blood loss ( EBL ) in ORP series range widely rom 385 to...1,550 mL per case, resulting in a 4% to 55.7% RP transfusion rate [23]. Studies have implicated EBL as significant mediator of blood transfusions...hospital length f stay, and postoperative complications [24]. In addition, igher EBL has been associated with a higher risk of anas- omotic stricture

  7. Particle-based Nano-Antennas at the Vis-NIR regime

    Science.gov (United States)

    2013-11-01

    arrays, which were produced by lift technique, employing electron beam lithography ( EBL ) on a glass substrate covered with 30nm ITO layer to...beam lithography ( EBL ) on a glass substrate covered with 30 nm Indium Tin Oxides (ITO) layer to eliminate charging effects. The thickness of the...controlled fabrication method using electron beam lithography ( EBL ) enabling a tight control of MNP array parameters such as particle size, shape

  8. Reconfigurable Nano-Plasmonics Holography

    Science.gov (United States)

    2013-04-01

    utilized fixed structures lithographically fabricated by focused ion beam (FIB) or e-beam lithography ( EBL ) and therefore, 4 did not provide...concentration. This was done by spinning on PMMA and then areas with structures that need to be released were exposed with EBL and developed away. When the device...2) Spin on PMMA and then EBL to open release windows; 3) Develop away exposed areas and release beams, etc., in liquid oxide etch; 4) remove PMMA by

  9. Design of a Multi-Segmented Robot for Hull Climbing

    Science.gov (United States)

    2013-09-01

    transition). 3.4.1 Elastomer Bow Linkage The elastomer bow linkage ( EBL ) (Figure 9) was pursued because it appeared that it would provide both...prototype robot. The linkage looked exactly the same as the EBL except that it was fabricated from a piece of plywood that made the entire robot...structure rigid. The robot could traverse obstacles similar to those of the EBL as long as it was perpendicular to the obstacle. The rigid linkage did

  10. High-Resolution, Low-Cost Spectrometer-on-Chip

    Science.gov (United States)

    2015-01-02

    increase the performance of the devices. All the prototype chips were made using Electron Beam Lithography ( EBL ) and reactive ion etching (RIE). Specific...the input coupling efficiency when using inverted tapers. In total, more than 50 designs were fabricated by EBL and plasma etching in order to...performance (DPH reflectivity, channel numbers, etc…) of the imprinted chips are very close to the ones made by EBL . Around 100 chips were

  11. An empirical approach to the extragalactic background light from AEGIS galaxy SED-type fractions

    OpenAIRE

    Domínguez, Alberto

    2011-01-01

    The extragalactic background light (EBL) is of fundamental importance both for understanding the entire process of galaxy evolution and for gamma-ray astronomy. However, the overall spectrum of the EBL between 0.1 and 1000 microns has never been determined directly neither from observed luminosity functions (LFs), over a wide redshift range, nor from any multiwavelength observation of galaxy spectral energy distributions (SEDs). The evolving, overall spectrum of the EBL is derived here utiliz...

  12. Graphene-based Nanoelectronics

    Science.gov (United States)

    2013-02-01

    structures such as metal-insulator-graphene tunnel junctions, designs and fabrication processes were developed based on e-beam lithography ( EBL ...capable of minimum feature sizes of 7 nm. A variety of high-resolution photoresists were tested with the EBL system to produce graphene structures with...Initiative e-textiles electronic textiles EBL e-beam lithography EDX emergy-dispersive x-ray spectroscopy EIS electrochemical impedance

  13. Structured Nanowires for Spectra-Tuned and Spectra-Multiplexed Sensing THZ Generation

    Science.gov (United States)

    2015-04-08

    method 3.4. EBL fabrication method 3.5. Diameter modulation 3.6. Optical characteristics 3.7. Contact studies 3.7.1. Geometry and size effects...nanowires enabled by e-beam lithography. Figure 4 Example of EBL diameter modulated Bi nanowire produced by our laboratory, at different...methods including e-beam lithography ( EBL ), focused ion beam (FIB) milling, and reactive ion etching (RIE) to create highly customizable structures

  14. Deterministic Aperiodic Structures for on-chip Nanophotonics and Nanoplasmonics Device Applications

    Science.gov (United States)

    2013-04-01

    nanolithographic techniques such as electron beam lithography ( EBL ) or Focused Ion Beam (FIB) milling followed by standard metal deposition and...immediately after the EBL writing. The process flow for the fabrication of both metallic nanoparticle arrays and nano-hole patterns is illustrated in Fig. 4...writing techniques, such as EBL , focused ion beam lithography (FIB), and scanning probe microscopy (SPM), suffer from high operating costs and low

  15. Endoscopic band ligation with a water-jet scope for the treatment of colonic diverticular hemorrhage.

    Science.gov (United States)

    Ishii, Naoki; Itoh, Toshiyuki; Uemura, Masayo; Maruyama, Masataka; Horiki, Noriyuki; Setoyama, Takeshi; Matsuda, Michitaka; Suzuki, Shoko; Iizuka, Yusuke; Fukuda, Katsuyuki; Fujita, Yoshiyuki

    2010-07-01

    Although lower gastrointestinal bleeding generally has a less severe course and stops spontaneously in most cases without therapeutic intervention, some patients require endoscopic, surgical, or angiographic treatment depending on the nature of the bleeding. We applied endoscopic band ligation (EBL) with a water-jet scope to bleeding colonic diverticula and evaluated the efficacy and safety of EBL retrospectively. Five consecutive patients were diagnosed as having colonic diverticular hemorrhage, and were treated with EBL at St Luke's International Hospital in Tokyo from June 2009 to August 2009. Comorbid diseases, usage of anti-platelet agents, hemoglobin level on admission, procedural time, complications such as perforation and abscess formation, and rebleeding after EBL were retrospectively evaluated. In all cases, EBL achieved successful immediate hemostasis without any procedural complications. In four of five cases, bleeding colonic diverticula were everted after EBL. The mean length of hospital stay after EBL was 5 days (range 4-8 days). No patient exhibited clinical evidence of further bleeding during the mean follow-up period of 3 months (range 2-4 months), and no further intervention was needed after EBL. EBL with a water-jet scope is considered to be a safe and effective endoscopic treatment for colonic diverticular hemorrhage.

  16. Does sclerotherapy of remnant little oesophageal varices after endoscopic ligation have impact on the reduction of recurrent varices? Prospective study.

    Science.gov (United States)

    Grgov, Sasa; Stamenković, Perica

    2011-01-01

    Endoscopic band ligation (EBL) is superior to endoscopic injection sclerotherapy (EIS) of oesophageal varices, however, EBL is associated with a higher rate of variceal recurrences. To examine whether the reduction of recurrent varices can be achieved by additional sclerotherapy of remnant little varices after ligation. Forty-eight patients with liver cirrhosis who had previously bled from oesophageal varices were examined. Endoscopic therapy was performed in order to prevent recurrent variceal bleeding. I group: in 23 patients ligation of oesophageal varices with multi band ligation device was applied (EBL group). II group: in 25 patients sclerotherapy using polydocanol or absolute alcohol was applied after reducing the size of varices using ligation (EBL and EIS group). There was no statistically significant difference between the examined groups of patients in relation to the number of sessions for variceal eradication, recurrence of variceal bleeding, deterioration of portal gastropathy and mortality in the observed period from 18.8 +/- 18.6 months (EBL group) and 22.2 +/- 26.2 months (EBL and EIS group). Variceal recurrence was verified in 21.7% of patients of the EBL group and 16% of the EBL and EIS group, but the difference was not statistically important. Several complications, such as dysphagia and chest pain, were statistically more frequent in the EBL and EIS group of patients. The combined method of ligation and extra sclerosing of remnant small oesophageal varices after ligation does not have advantage in relation to the ligation alone.

  17. Effects of spatial fluctuations in the extragalactic background light on hard gamma-ray spectra

    Science.gov (United States)

    Kudoda, A. M.; Faltenbacher, A.

    2017-05-01

    This study investigates the impact of the fluctuations in the extragalactic background light (EBL) on the attenuation of the hard γ-ray spectra of distant blazars. EBL fluctuations occur on the scales up to 100 Mpc and are caused by the clustering of galaxies. The EBL photons interact with high-energy γ-rays via the electron-positron pair production mechanism: γ + γ΄ → e+ + e-. The attenuation of γ-rays depends on their energy and the density of the intervening EBL photon field. Using a simple model for the evolution of the mean EBL photon density, we implement an analytical description of the EBL fluctuations. We find that the amplitudes of the EBL energy density can vary by ±1 per cent as a function of environment. The EBL fluctuations lead to mild alterations of the optical depth or equivalently the transmissivity for γ-rays from distant blazars. Our model predicts maximum changes of ±10 per cent in the γ-ray transmissivity. However, this translates into marginal differences in the power-law slopes of currently observed γ-ray spectra. The slopes of deabsorbed γ-ray spectra differ by not more than ±1 per cent if EBL fluctuations are included.

  18. Effective exciton blocking by the hole-transporting material 5,10,15-tribenzyl-5H-diindolo[3,2-a:3′,2′-c]-carbazole (TBDI) in the tetraphenyldibenzoperiflanthene (DBP) based organic photovoltaic cells

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Jing; Yang, Fang [School of Materials Science and Engineering, Shanghai University, P.O. Box 143, 149 Yanchang Rd., Shanghai 200072 (China); Key Laboratory of Advanced Display and System Applications, Ministry of Education, Shanghai University, P.O. Box 143, 149 Yanchang Rd., Shanghai 200072 (China); Zheng, Yanqiong, E-mail: zhengyanqiong@shu.edu.cn [Key Laboratory of Advanced Display and System Applications, Ministry of Education, Shanghai University, P.O. Box 143, 149 Yanchang Rd., Shanghai 200072 (China); Shanghai Engineering Research Center of Flat Panel Display, Shanghai University, P.O. Box 143, 149 Yanchang Rd., Shanghai 200072 (China); Wei, Bin [Key Laboratory of Advanced Display and System Applications, Ministry of Education, Shanghai University, P.O. Box 143, 149 Yanchang Rd., Shanghai 200072 (China); Shanghai Engineering Research Center of Flat Panel Display, Shanghai University, P.O. Box 143, 149 Yanchang Rd., Shanghai 200072 (China); Zhang, Xiaowen [Guangxi Key Laboratory of Information Materials, Guilin University of Electronic Technology, 1 Jinji Road, Guilin 541004 (China); Zhang, Jianhua; Wang, Zixing [Key Laboratory of Advanced Display and System Applications, Ministry of Education, Shanghai University, P.O. Box 143, 149 Yanchang Rd., Shanghai 200072 (China); Shanghai Engineering Research Center of Flat Panel Display, Shanghai University, P.O. Box 143, 149 Yanchang Rd., Shanghai 200072 (China); Pu, Wenhong; Yang, Changzhu [School of Environmental Science and Engineering, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430074 (China)

    2015-12-01

    Graphical abstract: The hole-transporting materials of TBDI, NPB and TAPC were used as exciton blocking layer (EBL) in DBP based PHJs for successfully blocking the misdirected electrons. PHJ cell with TBDI showed an improvement of 36% in η{sub PCE} relative to the reference cell without any EBL, owing to enhanced optical electric field, stronger prevention of exciton quenching, and a smoother TBDI/DBP surface. - Highlights: • TBDI, NPB, and TAPC as exciton blocking layers (EBLs) all successfully improved the performance of DBP PHJs. • A highest η{sub PCE} improvement of 36% is obtained by TBDI EBL among the three EBLs. • Optical electric fields for the wavelength of 610 nm are significantly enhanced via inserting 10-nm EBLs. • PL spectra indicated stronger prevention of exciton quenching by TBDI. • AFM images suggested smoother donor/acceptor interface with TBDI EBL. - Abstract: To explore the novel application of the hole-transporting material (HTM) as exciton blocking layer (EBL) in small molecule organic photovoltaic (OPV) cells, we introduce a recently reported HTM, 5,10,15-tribenzyl-5H-diindolo[3,2-a:3′,2′-c]-carbazole (TBDI), and the other two traditional HTMs, N,N′-diphenyl-N,N′-bis(1-naphthyl)-1,1′-biphenyl-4,4′-diamine (NPB) and 1,1′-bis(di-4-tolylaminophenyl) cyclohexane (TAPC), to serve as EBLs in the tetraphenyldibenzoperiflanthene (DBP) based planar heterojunction cells. Due to the large band gap of these materials, the EBLs successfully block the misdirected electrons. The optimized devices including the EBLs of TBDI, NPB and TAPC achieve power conversion efficiency (η{sub PCE}) of 1.70%, 1.33%, and 1.33%, respectively, whereas the control device without any EBL shows a η{sub PCE} of only 1.25%. The optical simulation indicates that the maximum optical electric fields for the PHJs including 10-nm EBLs at the wavelength of 610 nm are significantly enhanced relative to that for the 20-nm DBP based control device. By impedance

  19. Enquiry-Based Learning: Experiences of First Year Chemistry Students Learning Spectroscopy

    Science.gov (United States)

    Lucas, Timothy; Rowley, Natalie M.

    2011-01-01

    We explored the experiences of first year chemistry students of an Enquiry-Based Learning (EBL) approach to learning spectroscopy. An investigation of how students' perceived confidences changed as a result of their experience of using EBL in the spectroscopy course was carried out. Changes in the students' perceived confidence, both in their…

  20. Foundation Studies for Nursing: Using enquiry based learning Sue Grandis Foundation studies for nursing: Using enquiry based learning , Garth Long , Palgrave Alan Glasper and Pam Jackson 482 £19.99 0333777387 0333777387 [Formula: see text].

    Science.gov (United States)

    2003-10-01

    Although problem-based learning (PBL) or enquiry-based learning (EBL) has been used in medical education in the UK, its use as a teaching approach in nurse education is embryonic. Few nursing curricula employ a purely EBL/PBL approach - although many courses are beginning to include it as a teaching method.

  1. Enquiry-Based Learning: Experiences of First Year Chemistry Students Learning Spectroscopy

    Science.gov (United States)

    Lucas, Timothy; Rowley, Natalie M.

    2011-01-01

    We explored the experiences of first year chemistry students of an Enquiry-Based Learning (EBL) approach to learning spectroscopy. An investigation of how students' perceived confidences changed as a result of their experience of using EBL in the spectroscopy course was carried out. Changes in the students' perceived confidence, both in their…

  2. Enquiry-Based Learning: Perspectives on Practice

    Science.gov (United States)

    Deignan, Tim

    2009-01-01

    Traditional lecture-based teaching methods are being replaced or supplemented by approaches which call for reframing the roles and identities of teachers and learners. Enquiry-Based Learning (EBL) is one such approach. This paper reports on a study investigating the perceptions of staff and students (N=25) involved in an EBL capacity building…

  3. Online Problem-Based and Enquiry-Based Learning in the Training of Educational Psychologists

    Science.gov (United States)

    Bozic, Nick; Williams, Huw

    2011-01-01

    Over the past 40 years, problem-based learning (PBL) and enquiry-based learning (EBL) approaches have been used in a variety of professional training courses. More recently online versions of these pedagogies have been developed. This paper explains how online PBL and EBL activities have been incorporated into the professional training of…

  4. Endoscopic band ligation for bleeding lesions in the small bowel.

    Science.gov (United States)

    Ikeya, Takashi; Ishii, Naoki; Shimamura, Yuto; Nakano, Kaoru; Ego, Mai; Nakamura, Kenji; Takagi, Koichi; Fukuda, Katsuyuki; Fujita, Yoshiyuki

    2014-10-16

    To investigate the safety and efficacy of endoscopic band ligation (EBL) for bleeding lesions in the small bowel. This is a retrospective study evaluating EBL in six consecutive patients (three males, three females, 46-86 years of age) treated between May 2009 and February 2014: duodenal vascular ectasia; 1, jejunal bleeding diverticulum; 1, ileal Dieulafoy's lesion; 1 and ileal bleeding diverticula; 3. The success of the initial hemostasis was evaluated, and patients were observed for early rebleeding (within 30 d after EBL), and complications such as perforation and abscess formation. Follow-up endoscopies were performed in four patients. Initial hemostasis was successfully achieved with EBL in all six patients. Eversion was not sufficient in four diverticular lesions. Early rebleeding occurred three days after EBL in one ileal diverticulum, and a repeat endoscopy revealed dislodgement of the O-band and ulcer formation at the banded site. This rebleeding was managed conservatively. Late rebleeding occurred in this case (13 and 21 mo after initial EBL), and re-EBL was performed. Follow-up endoscopies revealed scar formation and the disappearance of vascular lesions at the banded site in the case with a duodenal bleeding lesion, and unresolved ileal diverticula in three cases. Surgery or transarterial embolization was not required without any complications during the median follow-up period of 45 (range, 2-83) mo. EBL is a safe and effective endoscopic treatment for hemostasis of bleeding lesions in the small bowel.

  5. Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass

    DEFF Research Database (Denmark)

    Dirksen, C; Jørgensen, N B; Bojsen-Møller, K N

    2013-01-01

    Objective:To identify factors contributing to the variation in weight loss after Roux-en-Y gastric bypass (RYGB).Design:Cross-sectional study of patients with good (excess body mass index lost (EBL) >60%) and poor weight loss response (EBL 12 months after RYGB and a lean control group matched...

  6. Endoscopic ultrasound findings predict the recurrence of esophageal varices after endoscopic band ligation: a prospective cohort study.

    Science.gov (United States)

    Masalaite, Laura; Valantinas, Jonas; Stanaitis, Juozas

    2015-01-01

    Variceal recurrence following endoscopic band ligation (EBL) is common. Esophageal collateral veins (ECV) are observed by endoscopic ultrasound (EUS) in patients with portal hypertension. The aim of the present study was to assess the role of EUS in predicting the recurrence of esophageal varices following EBL. Forty patients who had undergone EBL for eradication of varices were examined over a 12-month period to detect variceal recurrence. EUS was performed before ligation to detect and describe the type, grade, and the number of ECV. EUS findings obtained prior to EBL were compared in the variceal recurrence and non-recurrence groups. Of the 40 patients, 19 (47.5%) had variceal recurrence within 12 months of EBL. Univariate logistic regression analysis showed that severe peri-ECV (p EBL. Multivariate logistic regression model found that only severe peri-ECV (odds ratio [OR] = 24.39; 95% confidence interval [CI]: 2.34-253.78) and multiple peri-ECV (OR = 24.39; 95% CI: 2.34-253.78) remained as independent prognostic factors for variceal recurrence. The sensitivity and specificity of multivariate logistic regression model in predicting variceal recurrence was 89.2% and 90.5%, respectively (prognostic value (AUC) = 0.946). Recurrence rate of esophageal varices after EBL is high (47.5%). EUS can clearly depict ECV and has a value in predicting variceal recurrence after EBL; severe peri-ECV and multiple peri-ECV were significant and independent prognostic factors associated with variceal recurrence risk.

  7. Design of a Multi-Segmented Magnetic Robot for Hull Inspection

    Science.gov (United States)

    2014-09-01

    linkage ( EBL ) (Figure 9) was pursued because it appeared that it would provide both the flexibility for maintaining wheel contact and the transmission...exactly the same as the EBL except that it was fabricated from a piece of Figure 8. Drive module assembly. Figure 7. Drive module assembly exploded view

  8. Reconfigurable Optical Elements Based on Single and Coupled Microdisk Resonators with Quantum DOT Active Media

    Science.gov (United States)

    2012-06-29

    thinned using a thinner to obtain one micron thick films. The dye doped films were later patterned using either EBL or photolithography. Scanning...established for the microdisk resonators. Scanning electron microscope images of single and coupled microring resonators fabricated using EBL are shown

  9. Reconfigurable Cellular Photonic Crystal Arrays (RCPA)

    Science.gov (United States)

    2013-03-01

    and thin the top Si layer down to 240nm through thermal oxidation. Then through a round of Electron Beam Lithography ( EBL ) the passive optical...using a JBX-9300FS e-beam lithography ( EBL ) system, followed by plasma etching using the CF4/CHF3 gas mixture. The integration of SiN to the SOI

  10. Pathogens Present in Acute Mangled Extremities From Afghanistan and Subsequent Pathogen Recovery

    Science.gov (United States)

    2015-01-01

    Total Blood Products (Units) PRBC (Units) FFP (Units) Platelets (Units) Whole Blood (Units) Cryoprecipitate (Units) Crystalloid (mL) EBL (mL) First... EBL , estimated blood loss at time of surgery; ICU, intensive care unit. TABLE I. Wound Patterns, Injury Severity, and Amputation Status of Patients

  11. Determining the resolution limits of electron-beam lithography: direct measurement of the point-spread function.

    Science.gov (United States)

    Manfrinato, Vitor R; Wen, Jianguo; Zhang, Lihua; Yang, Yujia; Hobbs, Richard G; Baker, Bowen; Su, Dong; Zakharov, Dmitri; Zaluzec, Nestor J; Miller, Dean J; Stach, Eric A; Berggren, Karl K

    2014-08-13

    One challenge existing since the invention of electron-beam lithography (EBL) is understanding the exposure mechanisms that limit the resolution of EBL. To overcome this challenge, we need to understand the spatial distribution of energy density deposited in the resist, that is, the point-spread function (PSF). During EBL exposure, the processes of electron scattering, phonon, photon, plasmon, and electron emission in the resist are combined, which complicates the analysis of the EBL PSF. Here, we show the measurement of delocalized energy transfer in EBL exposure by using chromatic aberration-corrected energy-filtered transmission electron microscopy (EFTEM) at the sub-10 nm scale. We have defined the role of spot size, electron scattering, secondary electrons, and volume plasmons in the lithographic PSF by performing EFTEM, momentum-resolved electron energy loss spectroscopy (EELS), sub-10 nm EBL, and Monte Carlo simulations. We expect that these results will enable alternative ways to improve the resolution limit of EBL. Furthermore, our approach to study the resolution limits of EBL may be applied to other lithographic techniques where electrons also play a key role in resist exposure, such as ion-beam-, X-ray-, and extreme-ultraviolet lithography.

  12. Nanoimprinted DWDM laser arrays on indium phosphide substrates

    DEFF Research Database (Denmark)

    Smistrup, Kristian; Nørregaard, Jesper; Mironov, Andrej

    2014-01-01

    shift in the grating, and are single mode with high side-mode suppression. Typically, such lasers are patterned using e-beam lithography (EBL). We present a fabrication method based on patterning by thermal nanoimprint lithography, which is potentially less costly and faster than EBL. Thermal...

  13. Assessment of Users to Control Simulated Junctional Hemorrhage with the Combat Ready Clamp (CRoC)

    Science.gov (United States)

    2013-01-30

    CRoC™’s vertical arm to the manikin torso, was mea- sured in centimeters by using a ruler. Estimated blood loss ( EBL ) recovered from manikin drain...the median values for each user. Figure 4. Correlation between estimated blood loss ( EBL ) volume and total time to stop bleeding for each user by

  14. Colloidal Metamaterials at Optical Frequencies

    Science.gov (United States)

    2014-07-18

    structured at a subwavelength scale, using conventional lithographic approaches auch as electron beam lithography ( EBL ) or focused ion beam (FIB) milling...complex nanostructures with feature sizes on the sub- 10-nm scale. (8-10) Unlike EBL or FIB, nanoparticle self-assembly has the potential to produce three

  15. Studer Group® ' s evidence-based leadership initiatives.

    Science.gov (United States)

    Schuller, Kristin A; Kash, Bita A; Gamm, Larry D

    2015-01-01

    The purpose of this paper is to analyze the implementation of an organizational change initiative--Studer Group®'s Evidence-Based Leadership (EBL)--in two large, US health systems by comparing and contrasting the factors associated with successful implementation and sustainability of the EBL initiative. This comparative case study assesses the responses to two pairs of open-ended questions during in-depth qualitative interviews of leaders and managers at both health systems. Qualitative content analysis was employed to identify major themes. Three themes associated with success and sustainability of EBL emerged at both health systems: leadership; culture; and organizational processes. The theme most frequently identified for both success and sustainability of EBL was culture. In contrast, there was a significant decline in salience of the leadership theme as attention shifts from success in implementation of EBL to sustaining EBL long term. Within the culture theme, accountability, and buy-in were most often cited by interviewees as success factors, while sense of accountability, buy-in, and communication were the most reported factors for sustainability. Cultural factors, such as accountability, staff support, and communication are driving forces of success and sustainability of EBL across both health systems. Leadership, a critical factor in several stages of implementation, appears to be less salient as among factors identified as important to longer term sustainability of EBL.

  16. The Imprint of The Extragalactic Background Light in the Gamma-Ray Spectra of Blazars

    CERN Document Server

    ,

    2012-01-01

    The light emitted by stars and accreting compact objects through the history of the Universe is encoded in the intensity of the extragalactic background light (EBL). Knowledge of the EBL is important to understand the nature of star formation and galaxy evolution, but direct measurements of the EBL are lim- ited by Galactic and other foreground emissions. Here we report an absorption feature seen in the combined spectra of a sample of gamma-ray blazars out to a redshift of z$\\sim$1.6. This feature is caused by attenuation of gamma rays by the EBL at optical to UV frequencies, and allowed us to measure the EBL flux density in this frequency band.

  17. Performance improvement of blue light-emitting diodes with an AlInN/GaN superlattice electron-blocking layer

    Institute of Scientific and Technical Information of China (English)

    Zhao Fang; Yao Guang-Rui; Song Jing-Jing; Ding Bin-Bin; Xiong Jian-Yong; Su Chen; Zheng Shu-Wen

    2013-01-01

    The characteristics of a blue light-emitting diode (LED) with an AlInN/GaN superlattice (SL) electron-blocking layer (EBL) are analyzed numerically.The cartier concentrations in the quantum wells,energy band diagrams,electrostatic fields,and internal quantum efficiency are investigated.The results suggest that the LED with an AlInN/GaN SL EBL has better hole injection efficiency,lower electron leakage,and smaller electrostatic fields in the active region than the LED with a conventional rectangular AlGaN EBL or a A1GaN/GaN SL EBL.The results also indicate that the efficiency droop is markedly improved when an AlInN/GaN SL EBL is used.

  18. 24-Epibrassinolide ameliorates the adverse effect of salt stress (NaCl on pepper (Capsicum annuum L.

    Directory of Open Access Journals (Sweden)

    Ibn Maaouia-Houimli Samira

    2012-04-01

    Full Text Available The present study investigates the role of 24-epibrassinolide (EBL in inducing plant tolerance to salinity. Seedlings of pepper (Capsicum annuum L. were grown in the presence of 70 mM NaCl and were sprayed with 10-6 M EBL at 7 days after transplantation and were sampled at 28 day. The plants exposed to NaCl exhibited a significant decline in relative growth rate, net CO2 assimilation, stomatal conductance, transpiration and water use efficiency. However, the follow up treatment with EBL significantly improved the above parameters. EBL treated plants had greater relative growth rate compared to untreated plants when exposed to salt stress. Application of EBL increased photosynthesis by increasing stomatal conductance in both control and salt stressed plants and may have contributed to the enhanced growth. The water use efficiency was improved because CO2 assimilation is more important than the transpiration.

  19. Comparison of the copy numbers of bovine leukemia virus in the lymph nodes of cattle with enzootic bovine leukosis and cattle with latent infection.

    Science.gov (United States)

    Somura, Yoshiko; Sugiyama, Emi; Fujikawa, Hiroshi; Murakami, Kenji

    2014-10-01

    To establish a diagnostic index for predicting enzootic bovine leukosis (EBL), proviral bovine leukemia virus (BLV) copies in whole blood, lymph nodes and spleen were examined by quantitative real-time PCR (qPCR). Cattle were divided into two groups, EBL and BLV-infected, based on meat inspection data. The number of BLV copies in all specimens of EBL cattle was significantly higher than those of BLV-infected cattle (p < 0.0001), and the number of BLV copies in the lymph nodes was particularly large. Over 70 % of the superficial cervical, medial iliac and jejunal lymph nodes from EBL cattle had more than 1,000 copies/10 ng DNA, whereas lymph nodes from BLV-infected cattle did not. These findings suggest that the cattle harboring more than 1,000 BLV copies may be diagnosed with EBL.

  20. Genetic heterogeneity among bovine leukemia viruses in Japan and their relationship to leukemogenicity.

    Science.gov (United States)

    Inoue, Emi; Matsumura, Keiko; Maekawa, Kohei; Nagatsuka, Kenta; Nobuta, Miwako; Hirata, Moe; Minagawa, Airi; Osawa, Yoshiaki; Okazaki, Katsunori

    2011-07-01

    Bovine leukemia virus (BLV) infection in cattle causes persistent lymphocytosis, and a few percent of infected animals develop lymphoid tumors, namely enzootic bovine leukosis (EBL). In this study, a 440-bp fragment of the env gene was amplified from 204 tumor samples collected from different regions of Japan and analyzed by restriction fragment length polymorphism (RFLP) to determine the association of BLV with EBL. Of the seven RFLP types defined, types I, II, and III were dominant and found in 12.7, 75.0, and 8.3% of tumor samples, respectively. Cattle harboring type III virus were significantly older than other animals at the time of diagnosis of EBL. Type III viruses were found in approximately 33% and 5.5% of Japanese Black and Holstein cattle, respectively, with EBL. These findings indicate that genetically distinct BLV was associated with EBL in Japan and that the genetic profile may influence the leukemogenicity of the virus.

  1. Tailoring of polarization in electron blocking layer for electron confinement and hole injection in ultraviolet light-emitting diodes

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Yu-Hsuan; Pilkuhn, Manfred H. [Department of Electrical Engineering, Institute of Microelectronics and Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan 70101, Taiwan (China); Fu, Yi-Keng; Chu, Mu-Tao [Electronics and Optoelectronics Research Laboratories, Industrial Technology Research Institute, Hsinchu 31040, Taiwan (China); Huang, Shyh-Jer, E-mail: yksu@mail.ncku.edu.tw, E-mail: totaljer48@gmail.com [Department of Electrical Engineering, Institute of Microelectronics and Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan 70101, Taiwan (China); Department of Electrical Engineering, University of California at Los Angeles, Los Angeles, California 90095 (United States); Su, Yan-Kuin, E-mail: yksu@mail.ncku.edu.tw, E-mail: totaljer48@gmail.com [Department of Electrical Engineering, Institute of Microelectronics and Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan 70101, Taiwan (China); Department of Electronic Engineering, Kun-Shan University, Tainan 71003, Taiwan (China); Wang, Kang L. [Department of Electrical Engineering, University of California at Los Angeles, Los Angeles, California 90095 (United States)

    2014-03-21

    The influence of the AlGaN electron blocking layer (EBL) with graded aluminum composition on electron confinement and hole injection in AlGaN-based ultraviolet light-emitting diodes (LEDs) are investigated. The light output power of LED with graded AlGaN EBL was markedly improved, comparing to LED with conventional EBL. In experimental results, a high increment of 86.7% can be obtained in light output power. Simulation analysis shows that via proper modification of the barrier profile from the last barrier of the active region to EBL, not only the elimination of electron overflow to p-type layer can be achieved but also the hole injection into the active region can be enhanced, compared to a conventional LED structure. The dominant factor to the performance improvement is shown to be the modulation of polarization field by the graded Al composition in EBL.

  2. Increased luminance of MEH-PPV and PFO based PLEDs by using salmon DNA as an electron blocking layer

    Energy Technology Data Exchange (ETDEWEB)

    Madhwal, Devinder, E-mail: devindermadhwal@gmail.co [Material Science Laboratory, Department of Electronic Science, University of Delhi South campus, Benito Juarez Road, New Delhi-110021 (India); Rait, S.S.; Verma, A.; Kumar, Amit; Bhatnagar, P.K.; Mathur, P.C. [Material Science Laboratory, Department of Electronic Science, University of Delhi South campus, Benito Juarez Road, New Delhi-110021 (India); Onoda, M. [Department of Electrical Engineering and Computer Science, University of Hyogo, Himeji (Japan)

    2010-02-15

    The effect of salmon DNA-CTMA as an electron blocking layer (EBL) has been examined on the performance of MEH-PPV and PFO-based light emitting diodes. Though the turn-on voltage increases with incorporation of EBL, a significant increase in luminance and luminous efficiency for both the devices is observed. The EBL improves the device performance by blocking electrons at the EBL-polymer interface, thereby increasing the recombination probability of electrons and holes. The luminance of the MEH-PPV based Bio-LED increases to 100 cd/m{sup 2} from 30 cd/m{sup 2} while a corresponding increase for the PFO based LED is to 160 cd/m{sup 2} from 80 cd/m{sup 2} with and without EBL, respectively.

  3. Effects of 24-epibrassinolide on plant growth, osmotic regulation and ion homeostasis of salt-stressed canola.

    Science.gov (United States)

    Liu, J; Gao, H; Wang, X; Zheng, Q; Wang, C; Wang, X; Wang, Q

    2014-03-01

    This study evaluated effects of foliar spraying 24-epibrassinoide (24-EBL) on the growth of salt-stressed canola. Seedlings at the four-leaf stage were treated with 150 mM NaCl and different concentrations of 24-EBL (10(-6), 10(-8), 10(-10), 10(-12) M) for 15 days. A concentration of 10(-10) M 24-EBL was chosen as optimal and used in a subsequent experiment on plant biomass and leaf water potential parameters. The results showed that 24-EBL mainly promoted shoot growth of salt-stressed plants and also ameliorated leaf water status. Foliar spraying of salt-stressed canola with 24-EBL increased osmotic adjustment ability in all organs, especially in younger leaves and roots. This was mainly due to an increase of free amino acid content in upper leaves, soluble sugars in middle leaves, organic acids and proline in lower leaves, all of these compounds in roots, as well as essential inorganic ions. Na(+) and Cl(-) sharply increased in different organs under salt stress, and 24-EBL reduced their accumulation. 24-EBL improved the uptake of K(+), Ca(2+), Mg(2+) and NO3(-) in roots, which were mainly transported to upper leaves, while NO3(-) was mainly transported to middle leaves. Thus, 24-EBL improvements in ion homeostasis of K(+)/Na(+), Ca(2+)/Na(+), Mg(2+)/Na(+) and NO3(-)/Cl(-), especially in younger leaves and roots, could be explained. As most important parts, younger leaves and roots were the main organs protected by 24-EBL via improvement in osmotic adjustment ability and ion homeostasis. Further, physiological status of growth of salt-stressed canola was ameliorated after 24-EBL treatment. © 2013 German Botanical Society and The Royal Botanical Society of the Netherlands.

  4. Epibrassinolide induces changes in indole-3-acetic acid, abscisic acid and polyamine concentrations and enhances antioxidant potential of radish seedlings under copper stress.

    Science.gov (United States)

    Choudhary, Sikander Pal; Bhardwaj, Renu; Gupta, Bishan Datt; Dutt, Prabhu; Gupta, Rajinder Kumar; Biondi, Stefania; Kanwar, Mukesh

    2010-11-01

    In the present study, the effects of epibrassinolide (EBL) on indole-3-acetic acid (IAA), abscisic acid (ABA) and polyamine (PA) tissue concentrations and antioxidant potential of 7-day-old Raphanus sativus L. cv. 'Pusa chetki' seedlings grown under Cu stress were investigated. EBL treatment alone or in combination with Cu enhanced free and bound IAA titers when compared with the metal alone. Modest increases in free and bound ABA contents were observed for EBL treatment alone. However, the combination of EBL with Cu caused major increases in both forms of ABA, over Cu alone. Among the PAs analyzed, only putrescine and cadaverine concentrations were enhanced by EBL treatment alone. By contrast, a significant decline in putrescine and spermine contents was found in seedlings treated with EBL plus Cu. EBL treatments alone or in combination with Cu enhanced activities of guaiacol peroxidase (EC1.11.1.7), catalase (EC 1.11.1.6), superoxide dismutase (EC 1.15.1.1) and glutathione reductase (EC 1.6.4.2) and protein contents in comparison with metal and control treatments. A major decrease in malondialdehyde content was also recorded for EBL treatments with or without Cu. An increase in phytochelatin content was also observed in seedlings treated with EBL alone or in combination with Cu. Major improvement in radical scavenging activities, as attested by the antioxidant activity assay using DPPH (1,1-diphenylpicrylhydrazyl), and elevated deoxyribose and reducing powers, along with increased contents of ascorbic acid, total phenols and proline, also suggest a major influence of EBL application in mitigating copper-induced oxidative stress in radish seedlings. Copyright © Physiologia Plantarum 2010.

  5. Endoscopic band ligation for colonic diverticular hemorrhage.

    Science.gov (United States)

    Ishii, Naoki; Setoyama, Takeshi; Deshpande, Gautam A; Omata, Fumio; Matsuda, Michitaka; Suzuki, Shoko; Uemura, Masayo; Iizuka, Yusuke; Fukuda, Katsuyuki; Suzuki, Koyu; Fujita, Yoshiyuki

    2012-02-01

    The number of sample cases of colonic diverticular hemorrhage treated with endoscopic band ligation (EBL) has been small to date. To elucidate the safety and efficacy of EBL for colonic diverticular hemorrhage. Retrospective study. General hospital. A total of 29 patients with 31 colonic diverticula with stigmata of recent hemorrhage (SRH). Urgent colonoscopy was performed after bowel preparation. When diverticula with SRH were identified, marking with hemoclips was done near the diverticula. The endoscope was removed and reinserted after a band-ligator device was attached to the tip of endoscope. At first, EBL was attempted. In patients who could not be treated with EBL, epinephrine injection or endoscopic clipping was performed. Procedure time, rate of hemostasis and rebleeding, complications. The mean procedure time was 47 ± 19 minutes. EBL was successfully completed in 27 colonic diverticula (87%); except in 3 diverticula with a small orifice and large dome and 1 diverticula in which the orifice was too large. Early rebleeding after EBL occurred in 3 of 27 cases (11%). Although 2 cases of sigmoid rebleeding could be managed by repeat EBL or conservatively, right hemicolectomy was performed in 1 ascending diverticulum, in which the bleeding source was not identified on repeat colonoscopy. Scar formation at previously banded diverticula was identified in 7 of 11 patients who underwent follow-up colonoscopy. There were no complications after EBL in any of the patients. Retrospective study. EBL is a safe and effective treatment for colonic diverticular hemorrhage, and colonic diverticula resolve after EBL. Copyright © 2012 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.

  6. Comparison of long-term outcomes between endoscopic band ligation and endoscopic clipping for colonic diverticular hemorrhage.

    Science.gov (United States)

    Nakano, Kaoru; Ishii, Naoki; Ikeya, Takashi; Ego, Mai; Shimamura, Yuto; Takagi, Koichi; Nakamura, Kenji; Fukuda, Katsuyuki; Fujita, Yoshiyuki

    2015-10-01

    Long-term outcomes of endoscopic band ligation (EBL) for colonic diverticular hemorrhage have not been reported to date. The aim of this study was to determine the long-term outcomes of EBL and to retrospectively compare them with those of endoscopic clipping (EC) in the treatment of colonic diverticular hemorrhage. The study included patients with colonic diverticular hemorrhage who were treated with EBL or EC from January 2004 to November 2014 and followed up more than 1 year (61 patients in the EBL group and 39 patients in the EC group). Time-to-event analysis of rebleeding was performed with the Kaplan-Meier method. A follow-up colonoscopy was performed to confirm the disappearance of the banded diverticula in the EBL group. Rebleeding occurred in 21 patients in the EBL group and in 26 patients in the EC group. The cumulative incidence of rebleeding at 1, 12, 24, and 36 months after first treatments was 14 %, 23 %, 26 %, and 41 % in the EBL group and 38 %, 49 %, 59 %, and 68 % in the EC group, respectively. Time-to-event analysis revealed statistically significant data (Log-rank test, P = 0.0036). Scar formation with fold convergence at the previously banded site was observed in 11 of 24 patients who underwent follow-up colonoscopy (46 %). However, late rebleeding (rebleeding more than 30 days after EBL) occurred in five of these 11 cases. EBL was superior to EC in the treatment of colonic diverticular hemorrhage. However, the risk of rebleeding was not avoided even after the diverticula had been resolved using EBL.

  7. Differences in bleeding behavior after endoscopic band ligation: a retrospective analysis.

    Science.gov (United States)

    Petrasch, Florian; Grothaus, Johannes; Mössner, Joachim; Schiefke, Ingolf; Hoffmeister, Albrecht

    2010-01-15

    Endoscopic band ligation (EBL) is generally accepted as the treatment of choice for bleeding from esophageal varices. It is also used for secondary prophylaxis of esophageal variceal hemorrhage. However, there is no data or guidelines concerning endoscopic control of ligation ulcers. We conducted a retrospective study of EBL procedures analyzing bleeding complications after EBL. We retrospectively analyzed data from patients who underwent EBL. We analyzed several data points, including indication for the procedure, bleeding events and the time interval between EBL and bleeding. 255 patients and 387 ligation sessions were included in the analysis. We observed an overall bleeding rate after EBL of 7.8%. Bleeding events after elective treatment (3.9%) were significantly lower than those after treatment for acute variceal hemorrhage (12.1%). The number of bleeding events from ligation ulcers and variceal rebleeding was 14 and 15, respectively. The bleeding rate from the ligation site in the group who underwent emergency ligation was 7.1% and 0.5% in the group who underwent elective ligation. Incidence of variceal rebleeding did not vary significantly. Seventy-five percent of all bleeding episodes after elective treatment occurred within four days after EBL. 20/22 of bleeding events after emergency ligation occurred within 11 days after treatment. Elective EBL has a lower risk of bleeding from treatment-induced ulceration than emergency ligation. Patients who underwent EBL for treatment of acute variceal bleeding should be kept under medical surveillance for 11 days. After elective EBL, it may be reasonable to restrict the period of surveillance to four days or even perform the procedure in an out-patient setting.

  8. The importance of ports in the transport chain : challenges and opportunities / Dirk K. Behrendt = Значение портов в логистической цепочке : задачи и возможности / Дирк Берендт

    Index Scriptorium Estoniae

    Behrendt, Dirk K.

    2003-01-01

    Ettekanne 3.-4. detsembrini 2003 Tallinnas toimunud rahvusvahelisel konverents-näitusel "Logistics and transport in international trade" teeb ülevaate Euroopa, sh Läänemere sadamate ülesannetest, teenustest, konkurentsivõitlusest ning integreeritusest teiste transpordiliikidega

  9. The importance of ports in the transport chain : challenges and opportunities / Dirk K. Behrendt = Значение портов в логистической цепочке : задачи и возможности / Дирк Берендт

    Index Scriptorium Estoniae

    Behrendt, Dirk K.

    2003-01-01

    Ettekanne 3.-4. detsembrini 2003 Tallinnas toimunud rahvusvahelisel konverents-näitusel "Logistics and transport in international trade" teeb ülevaate Euroopa, sh Läänemere sadamate ülesannetest, teenustest, konkurentsivõitlusest ning integreeritusest teiste transpordiliikidega

  10. Endoscopic band ligation of internal haemorrhoids versus stapled haemorrhoidopexy in patients with portal hypertension.

    Science.gov (United States)

    Zaher, Tarik; Ibrahim, Islam; Ibrahim, Amany

    2011-03-01

    Portal hypertension is common in Egypt as a sequela to the high prevalence of hepatitis C virus and bilharziasis. In portal hypertension internal haemorrhoids are frequently found. The aim of this work was to compare the outcome of endoscopic band ligation (EBL) of symptomatic internal haemorrhoids with that of stapled haemorrhoidopexy (SH) in Egyptian patients with portal hypertension. In this study, 26 portal hypertensive patients (with oesophageal and/or fundal varices) with a grade 2-4 internal haemorrhoids who had no coagulation disorders were randomised to treatment by EBL (13 patients) or SH (13 patients) after doing colonoscopy. Symptom scores of bleeding and prolapse were assessed before and after the intervention. Complications were recorded. Patients were followed up for 12months. Goligher's grades of internal haemorrhoids improved significantly (p=0.018) 12weeks after SH (from 2.9±0.8 to 0.4±0.5; p=0.001) and after EBL (from 2.8±0.8 to 1.1±0.8; p=0.001). Symptom (bleeding and prolapse) scores significantly improved 4weeks after both EBL (from 1.6±0.8 to 0.6±0.8; pEBL and SH were not significant (p=0.168 and p=0.225). Pain requiring analgesics occurred in five patients (38.5%) after EBL, compared with six (46.2%) after SH (p=0.691). Minimal bleeding occurred in two patients (15.4%) after EBL but not with SH; urinary retention was observed in one patient after EBL compared with two after SH; and anal fissures were observed in one patient after EBL. During 1-year follow-up, increased frequency of stool occurred in one patient after EBL. Recurrence of symptoms was observed in three patients after EBL and in one after SH. For portal hypertensive patients with internal haemorrhoids and without coagulation disorders SH seems to be superior to EBL. However further studies are needed to evaluate EBL in different grades of cirrhosis. Copyright © 2011 Arab Journal of Gastroenterology. Published by Elsevier Ltd. All rights reserved.

  11. AFRRI (Armed Forces Radiobiology Research Institute) Reports, October, November and December 1987.

    Science.gov (United States)

    1988-03-01

    dependent manner radiation causes damage to the mucosa of the small intestine characterized by loss and denudation of villi and diminished crypt cell mito - S...Oxygen (ed. Autor A. P.), pp. 127-155. Academic Press, New York. 12. Dirks R. C. and Faiman M. D. (1982) Free radical formation and lipid peroxidation

  12. M-A-G-I-C viis marsruuti, viis pilku meie Euroopale

    Index Scriptorium Estoniae

    2006-01-01

    10. juunil Eesti Rahvusraamatukogus etendunud teatrivõrgustiku Magic Net (organisatsioon, mis ühendab 14 Euroopa teatrit) ühislavastusest "Peidetud lood" (Projekti juht Dirk Neldner). Arvustavad teatrikriitikud Rait Avestik, Madis Kolk, Ivar Põllu, Andres Keil ja üliõpilane Uku Uusberg

  13. 77 FR 40037 - Notice of the Peer Review Meeting for EPA's Draft Report Entitled An Assessment of Potential...

    Science.gov (United States)

    2012-07-06

    ... aquatic biology and ecotoxicology. Dr. Dirk van Zyl, University of British Columbia--Expertise in mining. Dr. Phyllis Weber Scannell--Expertise in aquatic ecology and ecotoxicology. Dr. Paul Whitney... aquatic biology. Dr. Charles Slaughter, University of Idaho--Expertise in hydrology. Dr. John Stednick...

  14. Democracy, globalization and ethnic violence

    NARCIS (Netherlands)

    Bezemer, D.J.; Jong-A-Pin, R.

    2013-01-01

    Bezemer, Dirk, and Jong-A-Pin, Richard Democracy, globalization and ethnic violence Do democratization and globalization processes combine to increase the incidence of violence in developing and emerging economies? The present paper examines this hypothesis by a study of internal violence in Sub-Sah

  15. Tshuzhoi Tanel Padar / Dmitri Babitshenko

    Index Scriptorium Estoniae

    Babitshenko, Dmitri

    2007-01-01

    Saksamaalt pärit, Eesti ülikoolides filmiteooria ja -ajaloo loenguid pidav ja filmi "Ring tee" valmimist režissöörina juhtinud Dirk Hoyeri mängufilm esilinastub 27. apr. kinos "Sõprus". Praeguseks on film ümber nimetatud "Võõraks", ühes peaosadest astub üles muusik Tanel Padar

  16. 30. III tutvustab Mooste külalisstuudio Tallinna Kunstihoone galeriis...

    Index Scriptorium Estoniae

    2005-01-01

    Tutvustatakse resideerimisprogrammi võimalusi ning keskkonnakunsti sümpoosioni "PostsovkhoZ". Ürituse kava (John Grzinichi lühifilm MoKSist", Dirk Lange näituse "ööTöö" avamine, ajakirja Palaster esitlus, Marcus Öhrnilt oma projekti, video ja performance'i tutvustus, Kurt Korthalsi, John Grzinichi kontsert jne.)

  17. Dynamic trapping of sliding drops on wetting defects

    NARCIS (Netherlands)

    Cavalli, A.; Musterd, M.; Mannetje, 't D.J.C.M.; Ende, van den H.T.M.; Mugele, F.

    2014-01-01

    Abstract Submitted for the DFD14 Meeting of The American Physical Society Dynamic trapping of sliding drops on wetting defects ANDREA CAVALLI, University of Twente, MICHIEL MUSTERD, TU Delft, DIETER ’T MANNETJE, DIRK VAN DEN ENDE, FRIEDER MUGELE, University of Twente —We present a numerical analysi

  18. 圣诞惊喜

    Institute of Scientific and Technical Information of China (English)

    Husky

    2007-01-01

    将诺维茨基(Dirk Nowitzki)塑造成超级巨星之后,跑回金州勇士队重做冯妇的尼尔森(Don Nelson)教练现在有个新作业,那就是年轻的长人毕耶德林斯(Andris Biedrins)。

  19. Dr D. F. van Slooten †

    NARCIS (Netherlands)

    Lam, H.J.

    1953-01-01

    On March 7, 1953 the Rijksherbarium suffered a severe loss by the sudden death of its honorary co-operator Dr. D. F. van Slooten, the wellknown specialist particularly of Dipterocarpaceae. To honour his memory the following lines may serve as an obituary note. Dirk Fok van Slooten was born in Amersf

  20. Teaching with Purpose: An Interview with Thomas E. Ludwig

    Science.gov (United States)

    Ludwig, Timothy D.; Ludwig, David J.

    2010-01-01

    Thomas E. Ludwig is the John Dirk Werkman Professor of Psychology at Hope College, where he joined the faculty in 1977 after receiving his PhD in development and aging from Washington University in St. Louis. His research focuses on developmental issues in cognitive neuropsychology. He is also the author or coauthor of more than a dozen sets of…

  1. Niklas Luhmanns teori om samfundets kommunikationssystemer

    DEFF Research Database (Denmark)

    Harste, Gorm

    2009-01-01

    Artiklen gennemgår Luhmanns kommunikationsteori og rekonstruerer den ud fra Dirk Baeckers reformulering af teorien om distinktioner, koder og mening. Artiklen hæfter sig i særlig grad ved organisationssystemerne og deres betydning i den historiske udfoldelse af kommunikation som semantik. Artikle...

  2. Filmische Biographiearbeit

    Directory of Open Access Journals (Sweden)

    Caroline Baetge

    2013-04-01

    Full Text Available Rezension zu: Medebach, Dirk H. 2011. Filmische Biographiearbeit im Bereich Demenz: eine soziologische Studie über Interaktion, Medien, Biographie und Identität in der stationären Pflege. Demenz, Bd. 2. Berlin: Lit-Verl.

  3. How Can Science Help Us Care for Nature? Hermeneutics, Fragility, and Responsibility for the Earth

    Science.gov (United States)

    Joldersma, Clarence W.

    2009-01-01

    In this review essay, Clarence Joldersma argues for a novel role for science in developing an affirmative answer to his title question, "How can science help us care for nature?" He does so in dialogue with Clare Palmer's edited volume, "Teaching Environmental Ethics," Dirk Postma's "Why Care for Nature?" and Michael Bonnett's "Retrieving Nature."…

  4. Transcriptomic footprints disclose specificity of reactive oxygen species signaling in Arabidopsis

    NARCIS (Netherlands)

    Gadjev, Ilya; Vanderauwera, Sandy; Gechev, Tsanko S.; Laloi, Christophe; Minkov, Ivan N.; Shulaev, Vladimir; Apel, Klaus; Inze, Dirk; Mittler, Ron; Van Breusegem, Frank

    2006-01-01

    Transcriptomic Footprints Disclose Specificity of Reactive Oxygen Species Signaling in Arabidopsis1,[W] Ilya Gadjev2, Sandy Vanderauwera2, Tsanko S. Gechev, Christophe Laloi, Ivan N. Minkov, Vladimir Shulaev, Klaus Apel, Dirk Inzé, Ron Mittler and Frank Van Breusegem* Department of Plant Systems Bio

  5. Mõtlemine algab kujustamisest / Igor Garšnek

    Index Scriptorium Estoniae

    Garšnek, Igor, 1958-

    2010-01-01

    2. detsembril toimunud kontserdist "The Music of the Image", kus esinesid Brüsseli Filharmoonikud, Lewis Morison, Gaelle Mechaly, Juanjo Mosalini ja Gabriel Yared Dirk Brosse dirigeerimisel ning 6. detsembril Estonia kontserdisaalis toimunud "Suurest filmimuusika kontserdist", kus esinesid Peterburi sümfooniaorkester Cinema ja Žanna Dombrovskaja Igor Ponomarenko juhatusel

  6. M-A-G-I-C viis marsruuti, viis pilku meie Euroopale

    Index Scriptorium Estoniae

    2006-01-01

    10. juunil Eesti Rahvusraamatukogus etendunud teatrivõrgustiku Magic Net (organisatsioon, mis ühendab 14 Euroopa teatrit) ühislavastusest "Peidetud lood" (Projekti juht Dirk Neldner). Arvustavad teatrikriitikud Rait Avestik, Madis Kolk, Ivar Põllu, Andres Keil ja üliõpilane Uku Uusberg

  7. First interactions from the Intersecting Storage Rings

    CERN Multimedia

    1971-01-01

    On 27 January 1971, Kjell Johnsen, who led the construction team which built the Intersecting Storage Rings (ISR), announced that the first ever interactions from colliding protons had been recorded. On the left are Franco Bonaudi, who was responsible for the civil engineering and Dirk Neet, who later took charge of ISR operations.

  8. Investigation of Pharmaceutical Residues in Hospital Effluents, in Ground- and Drinking Water from Bundeswehr Facilities, and their Removal During Drinking Water Purification (Arzneimittelrueckstaende in Trinkwasser(versorgungsanlagen) und Krankenhausabwaessern der Bundeswehr: Methodenentwicklung - Verkommen - Wasseraufbereitung)

    Science.gov (United States)

    1999-11-01

    Fluorchinolo- ne ( Ciprofloxacin , Norfloxacin , Enrofloxacin, Ofloxacin), Chloramphenicol, Lincomycin, Clindamycin und Trimethoprim mit Konzentrationen bis in den...water from Bundeswehr facilities, and their removal during drinking water purification) 6. AUTHOR(S) Th. Heberer, Dirk Feldmann, Marc Adam, Kirsten...occurrence and the removal of pharmaceutical residues was investigated In a scientific research project (InSan I 1299-V-7502) entitled "Investigation

  9. Teaching with Purpose: An Interview with Thomas E. Ludwig

    Science.gov (United States)

    Ludwig, Timothy D.; Ludwig, David J.

    2010-01-01

    Thomas E. Ludwig is the John Dirk Werkman Professor of Psychology at Hope College, where he joined the faculty in 1977 after receiving his PhD in development and aging from Washington University in St. Louis. His research focuses on developmental issues in cognitive neuropsychology. He is also the author or coauthor of more than a dozen sets of…

  10. European Military and Political Environment in a Post Cold War Era

    Science.gov (United States)

    1992-06-01

    34Banque mondiale et FMI en Tunisie : Une Liberalization in the Middle East, eds. Ilya Harik and Denis evolution sur trente ans." Annuaire de l’Afrique du...Monthly. (Spring 1991). Burgat, Francois. L’Islamisme au Maghreb: La voix du Sud . Vandewalle, Dirk. "From the New State to the New Era: Paris

  11. Role of electron blocking layer in III-nitride laser diodes and light-emitting diodes

    Science.gov (United States)

    Kuo, Yen-Kuang; Chang, Jih-Yuan; Chen, Mei-Ling

    2010-02-01

    A high energy bandgap electron blocking layer (EBL) just behind the active region is conventionally used in the nitride-based laser diodes (LDs) and light-emitting diodes (LEDs) to improve the confinement capability of electrons within the quantum wells. Nevertheless, the EBL may also act as a potential barrier for the holes and cause non-uniform distribution of holes among quantum wells. A most recent study by Han et al. (Appl. Phys. Lett. 94, 231123, 2009) reported that, because of the blocking effect for holes, the InGaN LED device without an EBL has slighter efficiency droop and higher light output at high level of current injection when compared with the LED device with an EBL. This result seems to contradict with the original intention of using the EBL. Furthermore, findings from our previous studies (IEEE J. Lightwave Technol. 26, 329, 2008; J. Appl. Phys. 103, 103115, 2008; Appl. Phys. Lett. 91, 201118, 2007) indicated that the utilization of EBL is essential for the InGaN laser diodes. Thus, in this work, the optical properties of the InGaN LDs and LEDs are explored numerically with the LASTIP simulation program and APSYS simulation program, respectively. The analyses focus particularly on the light output power, energy band diagrams, recombination rates, distribution of electrons and holes in the active region, and electron overflow. This study will then conclude with a discussion of the effect of EBL on the optical properties of the InGaN LDs and LEDs.

  12. Incidence of Endemic Burkitt Lymphoma in Three Regions of Mozambique.

    Science.gov (United States)

    O'Callaghan-Gordo, Cristina; Casabonne, Delphine; Carrilho, Carla; Ferro, Josefo; Lorenzoni, Cesaltina; Zaqueu, Clesio; Nhabomba, Augusto; Aguilar, Ruth; Bassat, Quique; de Sanjosé, Sílvia; Dobaño, Carlota; Kogevinas, Manolis

    2016-12-07

    Data on the burden and incidence of endemic Burkitt lymphoma (eBL) across Mozambique are scarce. We retrospectively retrieved information on eBL cases from reports of the three main hospitals of Mozambique: Maputo Central Hospital (MCH), Beira Central Hospital (BCH), and Nampula Central Hospital (NCH) between 2004 and 2014. For 2015, we prospectively collected information of new eBL cases attending these hospitals. A total of 512 eBL cases were reported between 2004 and 2015: 153 eBL cases were reported in MCH, 195 in BCH, and 164 in NCH. Mean age of cases was 6.9 years (standard deviation = 2.8); 63% (319/504) of cases were males. For 2015, the estimated incidence rate of eBL was 2.0, 1.7, and 3.9 per 10(6) person-year at risk in MCH, BCH, and NCH, respectively. Incidence was higher in NCH (northern Mozambique), where intensity of malaria transmission is higher. Data presented show that eBL is a common pediatric malignancy in Mozambique, as observed in neighboring countries. © The American Society of Tropical Medicine and Hygiene.

  13. Regulation of 2,4-epibrassinolide on mineral nutrient uptake and ion distribution in Ca(NO3)2 stressed cucumber plants.

    Science.gov (United States)

    Yuan, Lingyun; Zhu, Shidong; Shu, Sheng; Sun, Jin; Guo, Shirong

    2015-09-01

    2,4-Epibrassinolide (EBL) is a plant hormone that plays a pivotal role in regulation of plants growth and development processes under abiotic stress. The investigation was carried out to study the effect of EBL on mineral nutrients uptake and distribution with ion element analysis and X-ray microanalysis in cucumber seedlings (Cucumis sativus L. cv. Jinyou No.4) under 80 mM Ca(NO3)2 stress. Our study found EBL significantly alleviated the inhibitory of P, K, Na, Mg, Fe, Mn, or Cl uptake in shoot or root by Ca(NO3)2 stress. Under Ca(NO3)2 stress, X-ray microanalysis showed that high levels of Ca by EBL treatment accumulated in the epidermal cells of root and gradually decreased from epidermal cells to stellar parenchyma. K(+) levels were restored in different cross section of roots and high K(+) level mostly accumulated in stellar parenchyma. The results of Ca(2+) ultra-structural localization showed Ca(2+) particles of antimonite precipitate by EBL were partly decreased in mesophyll and root cells, and Ca(2+) precipitate distributed in intercellular spaces again. Increased Ca(2+)-ATPase activity and ATP content by EBL were also contributed to extrude excess Ca(2+) from the cytoplasm. These results suggested that EBL could alleviate the ion damage from excess Ca(2+) through regulating mineral nutrients uptake and distribution. Copyright © 2015 Elsevier GmbH. All rights reserved.

  14. Estimation of the extragalactic background light using TeV observations of BL Lac objects

    Energy Technology Data Exchange (ETDEWEB)

    Sinha, Atreyee; Acharya, B. S. [Department of High Energy Physics, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400005 (India); Sahayanathan, S.; Godambe, S. [Astrophysical Sciences Division, Bhabha Atomic Research Center, Mumbai (India); Misra, R., E-mail: atreyee@tifr.res.in, E-mail: acharya@tifr.res.in, E-mail: sunder@barc.ernet.in, E-mail: gsagar@barc.ernet.in, E-mail: rmisra@iucaa.ernet.in [Inter-University Center for Astronomy and Astrophysics, Post Bag 4, Ganeshkhind, Pune 411007 (India)

    2014-11-01

    The very high-energy (VHE) gamma-ray spectral index of high-energy peaked blazars correlates strongly with its corresponding redshift, whereas no such correlation is observed in the X-ray or GeV bands. We attribute this correlation to photon-photon absorption of TeV photons with the extragalactic background light (EBL), and utilizing this we compute the allowed flux range for the EBL, which is independent of previous estimates. The observed VHE spectrum of the sources in our sample can be well approximated by a power law, and if the de-absorbed spectrum is also assumed to be a power law, then we show that the spectral shape of EBL will be εn(ε) ∼ klog (ε/ε {sub p}). We estimate the range of values for the parameters defining the EBL spectrum, k and ε {sub p}, such that the correlation of the intrinsic VHE spectrum with redshift is nullified. The estimated EBL depends only on the observed correlation and the assumption of a power-law source spectrum. Specifically, it does not depend on the spectral modeling or radiative mechanism of the sources or on any theoretical shape of the EBL spectrum obtained through cosmological calculations. The estimated EBL spectrum is consistent with the upper and lower limits imposed by different observations. Moreover, it also agrees closely with the theoretical estimates obtained through cosmological evolution models.

  15. Cyanoacrylate injection versus band ligation for bleeding from cardiac varices along the lesser curvature of the stomach.

    Science.gov (United States)

    Park, Sang Jung; Kim, Yong Kwon; Seo, Yeon Seok; Park, Seung Woon; Lee, Han Ah; Kim, Tae Hyung; Suh, Sang Jun; Jung, Young Kul; Kim, Ji Hoon; An, Hyunggin; Yim, Hyung Joon; Jang, Jae Young; Yeon, Jong Eun; Byun, Kwan Soo

    2016-12-01

    Practice guidelines recommend endoscopic band ligation (EBL) and endoscopic variceal obturation (EVO) for bleeding from esophageal varices and fundal varices, respectively. However, the optimal treatment for bleeding from cardiac varices along the lesser curvature of the stomach (GOV1) remains undefined. This retrospective study compared the efficacy between EBL and EVO for bleeding from GOV1. Patients treated by EBL or EVO via cyanoacrylate injection for bleeding from GOV1 were enrolled. Patients diagnosed with hepatocellular carcinoma or treated with endoscopic injection sclerotherapy were excluded. The study included 91 patients treated for bleeding from GOV1. The mean age was 56.3±10.9 years (mean±SD), and 78 of them (85.7%) were men. Overall, 51 and 40 patients were treated with EBL and EVO, respectively. A trend for a higher hemostasis rate was noted in the EVO group (100%) than in the EBL group (82.6%, P=0.078). Varices rebled in 15 patients during follow-up. The rebleeding rate was significantly higher in the EBL group than in the EVO group (P=0.004). During follow-up, 13 patients died (11 in the EBL group and 2 in the EVO group); the survival rate was marginally significant between two groups (P=0.050). The rebleeding-free survival rate was significantly higher in the EVO group than in the EBL group (P=0.001). Compared to EBL, EVO offered significantly lower rebleeding rates, significantly higher rebleeding-free survival rates, and a trend for higher hemostasis and survival rates. EVO appears to be the better therapeutic option for bleeding from GOV1.

  16. New Spectral Evidence of an Unaccounted Component of the Near-infrared Extragalactic Background Light from the CIBER

    Science.gov (United States)

    Matsuura, Shuji; Arai, Toshiaki; Bock, James J.; Cooray, Asantha; Korngut, Phillip M.; Kim, Min Gyu; Lee, Hyung Mok; Lee, Dae Hee; Levenson, Louis R.; Matsumoto, Toshio; Onishi, Yosuke; Shirahata, Mai; Tsumura, Kohji; Wada, Takehiko; Zemcov, Michael

    2017-04-01

    The extragalactic background light (EBL) captures the total integrated emission from stars and galaxies throughout the cosmic history. The amplitude of the near-infrared EBL from space absolute photometry observations has been controversial and depends strongly on the modeling and subtraction of the zodiacal light (ZL) foreground. We report the first measurement of the diffuse background spectrum at 0.8-1.7 μm from the CIBER experiment. The observations were obtained with an absolute spectrometer over two flights in multiple sky fields to enable the subtraction of ZL, stars, terrestrial emission, and diffuse Galactic light. After subtracting foregrounds and accounting for systematic errors, we find the nominal EBL brightness, assuming the Kelsall ZL model, is {42.7}-10.6+11.9 nW m-2 sr-1 at 1.4 μm. We also analyzed the data using the Wright ZL model, which results in a worse statistical fit to the data and an unphysical EBL, falling below the known background light from galaxies at λ EBL brightness, we find an EBL brightness of {28.7}-3.3+5.1 nWm-2 sr-1 at 1.4 μm. While the derived EBL amplitude strongly depends on the ZL model, we find that we cannot fit the spectral data to ZL, Galactic emission, and EBL from solely integrated galactic light from galaxy counts. The results require a new diffuse component, such as an additional foreground or an excess EBL with a redder spectrum than that of ZL.

  17. Extraction of lignin from sugar cane bagasse and its modification into a high performance dispersant for pesticide formulations

    OpenAIRE

    Li, Zhili; Ge, Yuanyuan

    2011-01-01

    In order to effectively utilize a by-product of non-wood material, lignin was extracted from sugar cane bagasse via acidification of black liquor. The extracted sugar cane bagasse lignin (EBL) was modified by oxidation, hydroxymethylation, and sulfonation into a water-soluble lignosulfonate (EBL-M). It was characterized by IR, UV, GPC and elemental analysis. The results showed that the aromatic units of EBL-M were kept well and it was effectively sulfonated, that the percentage of S was high ...

  18. Detection of monoclonal integration of bovine leukemia virus proviral DNA as a malignant marker in two enzootic bovine leukosis cases with difficult clinical diagnosis

    OpenAIRE

    Miura, Saori; HORIUCHI, Noriyuki; Matsumoto, Kotaro; KOBAYASHI, Yoshiyasu; Kawazu, Shin-ichiro; INOKUMA, Hisashi

    2015-01-01

    Monoclonal integration of bovine leukemia virus (BLV) proviral DNA into bovine genomes was detected in peripheral blood from two clinical cases of enzootic bovine leukosis (EBL) without enlargement of superficial lymph nodes. A BLV-specific probe hybridized with 1 to 3 EcoRI and HindIII fragments in these 2 atypical EBL cattle by Southern blotting and hybridization, as well as in 3 typical EBL cattle. The probe also hybridized to a large number of EcoRI and HindIII fragments in 5 cattle with ...

  19. The eradication experience of enzootic bovine leukosis from Lithuania.

    Science.gov (United States)

    Acaite, J; Tamosiunas, V; Lukauskas, K; Milius, J; Pieskus, J

    2007-11-15

    Before 1985 the situation regarding enzootic bovine leukosis (EBL) in Lithuanian cattle was described only haphazardly. In 1986 serological investigations were initiated together with an eradication programme. The EBL bovine leukosis virus (BLV) situation was monitored by the Institute of Immunology Vilnius University, national and regional veterinary laboratories. Starting in 1986 all EBL-positive cattle were separated from negative cattle into BLV-infected and BLV-free herds. To create the latter, calves were fed pasteurized milk. The seroprevalence in 1990 was 7.29%, but it steadily declined to 0.32% in 2006.

  20. Efficiency improvement of light-emitting diodes with a developed electron blocking layer structure and its optimization

    Science.gov (United States)

    Wang, Tian-Hu; Xu, Jin-Liang; Wang, Xiao-Dong

    2013-01-01

    We study the internal quantum efficiency (IQE) of light-emitting diodes (LEDs) with an added AlxGa1-xN/GaN multi-quantum-barrier as the electron blocking layer (EBL) and optimize the structure parameter. Comparison was performed under same running conditions for LEDs with a single-barrier EBL (conventional design) and multi-quantum-barrier EBL. The numerical simulation shows that the IQE is significantly increased to 63.7% for the optimized structure parameters due to the modified energy band diagrams which are responsible for the enhanced carrier concentration in the active region.

  1. High breakdown voltage in AlGaN/GaN HEMTs using AlGaN/GaN/AlGaN quantum-well electron-blocking layers.

    Science.gov (United States)

    Lee, Ya-Ju; Yao, Yung-Chi; Huang, Chun-Ying; Lin, Tai-Yuan; Cheng, Li-Lien; Liu, Ching-Yun; Wang, Mei-Tan; Hwang, Jung-Min

    2014-01-01

    In this paper, we numerically study an enhancement of breakdown voltage in AlGaN/GaN high-electron-mobility transistors (HEMTs) by using the AlGaN/GaN/AlGaN quantum-well (QW) electron-blocking layer (EBL) structure. This concept is based on the superior confinement of two-dimensional electron gases (2-DEGs) provided by the QW EBL, resulting in a significant improvement of breakdown voltage and a remarkable suppression of spilling electrons. The electron mobility of 2-DEG is hence enhanced as well. The dependence of thickness and composition of QW EBL on the device breakdown is also evaluated and discussed.

  2. The Gamma Ray Opacity of the Universe -- Indirect Measurements of the Extragalactic Background Light

    CERN Document Server

    Krennrich, F

    2014-01-01

    Indirect constraints on the intensity of the Extragalactic Background Light (EBL) were provided by recent studies of extragalactic sources emitting sub-TeV to multi-TeV photons. These constraints are provided thanks to the absorption of gamma rays by soft photons from the EBL (UV/optical/IR) via pair production by gamma - gamma interactions. This paper provides an overview of recent results that have led to substantially reduced uncertainties on the EBL intensity over a wide range of wavelengths from 0.1 to 15 micron.

  3. The enquiry-based learning experience: An evaluation project.

    Science.gov (United States)

    Ashby, Jayne; Hubbert, Vanessa; Cotrel-Gibbons, Liz; Cox, Karen; Digan, John; Lewis, Kerry; Langmack, Gill; Matiti, Milika; McCormick, Damion; Roberts, Lorraine; Taylor, Derek; Thom, Natasha; Wiggs, Mary; Wilson, Linda

    2006-01-01

    A research and nursing development initiative group consisting of health lecturers and lecturer practitioners set out to evaluate how learners and teachers felt about the introduction of an enquiry based learning (EBL) approach to education. Five focus groups, teachers (1 group) post-registration students (1 group) and pre-registration diploma students (3 groups) were interviewed. Discussions were tape recorded, transcribed, and analysed. The results revealed that students and teachers held disparative views on the efficiency of EBL. Teachers, surprisingly, felt more doubtful and discouraged than learners. Several concerns were raised over the ability of EBL to establish a foothold in a curriculum more noted for a pedagogical stance on learning.

  4. Sickle cell trait is not associated with endemic Burkitt lymphoma: An ethnicity and malaria endemicity-matched case–control study suggests factors controlling EBV may serve as a predictive biomarker for this pediatric cancer

    Science.gov (United States)

    Mulama, David H; Bailey, Jeffrey A; Foley, Joslyn; Chelimo, Kiprotich; Ouma, Collins; Jura, Walter GZO; Otieno, Juliana; Vulule, John; Moormann, Ann M

    2014-01-01

    Endemic Burkitt lymphoma (eBL) is associated with Epstein–Barr virus (EBV) and Plasmodium falciparum coinfections. Malaria appears to dysregulate immunity that would otherwise control EBV, thereby contributing to eBL etiology. Juxtaposed to human genetic variants associated with protection from malaria, it has been hypothesized that such variants could decrease eBL susceptibility, historically referred to as “the protective hypothesis.” Past studies attempting to link sickle cell trait (HbAS), which is known to be protective against malaria, with protection from eBL were contradictory and underpowered. Therefore, using a case–control study design, we examined HbAS frequency in 306 Kenyan children diagnosed with eBL compared to 537 geographically defined and ethnically matched controls. We found 23.8% HbAS for eBL patients, which was not significantly different compared to 27.0% HbAS for controls [odds ratio (OR) = 0.85; 95% confidence interval (CI) 0.61–1.17; p-value = 0.33]. Even though cellular EBV titers, indicative of the number of latently infected B cells, were significantly higher (p-value eBL protection. However, based on receiver operating characteristic curves factors that enable the establishment of EBV persistence, in contrast to those involved in EBV lytic reactivation, may have utility as an eBL precursor biomarker. This has implications for future human genetic association studies to consider variants influencing control over EBV in addition to malaria as risk factors for eBL. What's new? Although the hypothesis dates back to 1970, studies of the “protective effect” of sickle cell trait (HbAS) on the development of endemic Burkitt lymphoma (eBL) have led to contradictory conclusions. This new study analyzed an unprecedented number of eBL cases and highlighted the importance of matching controls on ethnicity as well as malaria endemicity. The findings contribute to resolving the controversy by showing that HbAS frequency does

  5. Low Power Monolayer MoS2 Transistors for RF Applications

    Science.gov (United States)

    2015-03-24

    contrast, Raman spectroscopy, and atomic force microscopy (AFM) images. Device active regions were defined using e-beam lithography ( EBL ). Excess MoS...2 was etched using Cl2 plasma. Next, source/drain metal electrodes were defined with EBL . A stack of Ag/Au (20 nm/30 nm) was deposited as low-work...30 nm thick layer of HfOx as the top gate dielectric. The top gate electrode was then defined using a final EBL step. The top gate metal fingers

  6. Statistical Memristor Modeling and Case Study in Neuromorphic Computing

    Science.gov (United States)

    2012-06-01

    issues are related to fabrication processes, we mainly target the nano-scale pattern fabricated by electron beam lithography ( EBL ). The measurements show...0.4 nm Sk 0.1nm ∼ 0.2nm / / Ku 2.5nm ∼ 3.5nm which are caused by periodic composition in the EBL fabrication system; and (2) the line edge roughness...equally divide the entire line edge into many segments, say, n seg- ments. Without losing the LER properties in EBL process, we mod- ified the random LER

  7. Constraints on the Extragalactic Background Light from Very High Energy Gamma-Ray Observations of Blazars

    OpenAIRE

    Finke, Justin D.; Razzaque, Soebur

    2009-01-01

    The extragalactic background light (EBL) from the infrared to the ultraviolet is difficult to measure directly, but can be constrained with a variety of methods. EBL photons absorb gamma-rays from distant blazars, allowing one to use blazar spectra from atmospheric Cherenkov telescopes (ACTs) to put upper limits on the EBL by assuming a blazar source spectrum. Here we apply a simple technique, similar to the one developed by Schroedter (2005), to the most recent very-high energy (VHE) gamma-r...

  8. Three Dimensionally Interconnected Silicon Nanomembranes for Optical Phased Array (OPA) and Optical True Time Delay (TTD) Applications

    Science.gov (United States)

    2012-06-01

    lithography ( EBL ) and reactive-ion-etching (RIE) was described in [7]. After etching of the silicon device layer, a silicon dioxide layer of 1.5µm was...nanomembrane etching. The MMI coupler on the top layer was fabricated using the same EBL and RIE process as the one on the bottom layer. Fig. 5-1 (a...limitations, the trench width is fixed to 80 nm with a corresponding sub of 388 nm. The designed GC is fabricated using electron beam lithography ( EBL ) and

  9. The future of focused electron beam-induced processing

    Energy Technology Data Exchange (ETDEWEB)

    Hagen, C.W. [Delft University of Technology, Department of Imaging Physics, Faculty of Applied Sciences, Delft (Netherlands)

    2014-12-15

    A perspective is sketched for the field of focused electron beam-induced processing (FEBIP). The FEBIP lithography technique is compared to the very successful resist-based electron beam lithography (EBL) technique. The advantages of FEBIP over EBL are identified, the main advantage being its high spatial resolution. This will enable FEBIP to become an important lithography technique for the fabrication of devices with critical dimension in the range between 1 and 20 nm and serve as a complementary technique to EBL. It will be discussed what needs to be done to achieve this and what the potential applications are. (orig.)

  10. The Luminosity Function of Fermi-Detected Flat-Spectrum Radio Quasars

    Science.gov (United States)

    2012-05-11

    other possible sources of systematic uncertainty (detection efficiency, blazar variability, and absorption by extragalactic background light, EBL ) do not...few of the Fermi spectra. The fit is performed only for E < 20 GeV to avoid possible steeping due to the absorption of γ -ray photons by the EBL (e.g...uncertainties due to different level of the energy density of the EBL which would affect mostly the high-energy part of the SED (i.e., 20 GeV). Figure 9

  11. Morbidity of Early Spine Surgery in the Multiply Injured Patient

    Science.gov (United States)

    2014-07-31

    EBL ) were obtained by inspection of the 1212 Arch Orthop Trauma Surg (2014) 134:1211–1217 123 anesthesia record. If a patient underwent multiple proce...3.5. Mean operative time for the spine surgery was 3.7 h. Mean EBL from the anesthesia record was 902.5 mL (median 575), with a wide range noted...50 mL to 4 L). Eight (27 %) cases had EBL exceeding Table 1 Cohort characteristics Mean (median) Range Age (years) 27.6 (25.9) (19.3, 47.3) ISS 26.1

  12. Ion Source Development for a Compact Proton Beam Writing System III

    Science.gov (United States)

    2013-06-28

    100nm features. Electron beam lithography ( EBL ), a candidate for direct-write technology at nanodimensions has extensively been investigated for the...last four decades However, high resolution lines and spaces in single step exposures for EBL are limited to about 20-30 nm levels due to proximity...achieve writing speeds comparable to commercial EBL systems, we aim for a proton beam current of 1 pA with a beam reduced brightness of 0.2-5× 106 A

  13. Unveiling the cosmic history of light

    Science.gov (United States)

    Desai, Abhishek; Ajello, Marco; Hartmann, Dieter; Sharan Paliya, Vaidehi; Finke, Justin; Omodei, Nicola; Dominguez, Alberto; Helgason, Kári; Meyer, Manuel

    2017-08-01

    The extragalactic background light (EBL) is the collective emission of all the stars and galaxies over the history of the universe. The most efficient method to study the EBL is through the imprint it leaves via photon-photon annihilation in the spectra of distant gamma-ray sources. Here we present a combined analysis of gamma-ray data from GRBs and blazars detected by Fermi Large Area Telescope. This analysis allows us to probe the EBL up to much higher redshifts (z>4) and over a larger wavelength range. The details of this work and its implications will be discussed.

  14. A simple electron-beam lithography system

    DEFF Research Database (Denmark)

    Mølhave, Kristian; Madsen, Dorte Nørgaard; Bøggild, Peter

    2005-01-01

    A large number of applications of electron-beam lithography (EBL) systems in nanotechnology have been demonstrated in recent years. In this paper we present a simple and general-purpose EBL system constructed by insertion of an electrostatic deflector plate system at the electron-beam exit...... of the column of a scanning electron microscope (SEM). The system can easily be mounted on most standard SEM systems. The tested setup allows an area of up to about 50 x 50 pm to be scanned, if the upper limit for acceptable reduction of the SEM resolution is set to 10 run. We demonstrate how the EBL system can...

  15. Quantum Optics with Atom-like Systems in Diamond

    Science.gov (United States)

    2013-11-19

    devices device thickness, which is on the order of a few hundred nm. Devices are then defined on these thin films by e-beam lithography ( EBL ) using...the waveguide, again using HSQ as an EBL defined mask, as shown in Figure 6.2. We can characterize these cavities using by coupling a broadband light...with a surface layer of NV centers, we define 1D waveguide structures using EBL with PMMA as a resist. After developing the resist, the mask pattern

  16. Directed Self-Assembly of Epitaxial CoFe2O4-BiFeO3 Multiferroic Nanocomposites

    Science.gov (United States)

    2012-04-09

    scale polycrystalline CFO islands embed- ded in a PbTiO3 matrix have been fabricated using e-beam lithography ( EBL ) via a liftoff process, but such...creating a preferred nucleation site for the formation of Ge epitaxial quantum dots.19,20 Similarly, EBL has been used to form SiC on the substrate...of a substrate with CFO islands on the surface patterned using EBL . A top-down lithrographic process is employed to pattern CFO islands on the

  17. Energy-Efficient Phase-Change Memory with Graphene as a Thermal Barrier

    Science.gov (United States)

    2015-09-02

    G-PCM) device structure. The interfacial graphene layer is patterned by electron-beam lithography ( EBL ) to be as small as the effective contact area...the bottom electrode, followed by 30 nm of SiO2 by plasma-enhanced chemical vapor deposition (PECVD). The 100 kV EBL is then applied to pattern the...scaffold33 and patterned by EBL to be as small as the bottom W heater electrode, i.e., DG = DBE. The 10 nm GST is sputtered directly on top of the graphene

  18. A comparison of radical perineal, radical retropubic, and robot-assisted laparoscopic prostatectomies in a single surgeon series.

    Science.gov (United States)

    Mirza, Moben; Art, Kevin; Wineland, Logan; Tawfik, Ossama; Thrasher, J Brantley

    2011-01-01

    Objective. We sought to compare positive surgical margin rates (PSM), estimated blood loss (EBL), and quality of life outcomes (QOL) among perineal (RPP), retropubic (RRP), and robot-assisted laparoscopic (RALP) prostatectomies. Methods. Records from 463 consecutive men undergoing RPP (92), RRP (180), or RALP (191) for clinically localized prostate cancer were retrospectively reviewed. Age, percent tumor volume, Gleason score, stage, EBL, PSM, and QOL using the expanded prostate cancer index composite (EPIC) were compared. Results. PSM were similar when adjusted for stage, grade, and volume. EBL was significantly less in the RALP (189 ml) group compared to both RPP (475 ml) and RRP (999 ml) groups. When corrected for nerve sparing, there were no differences in erectile function and sexual function amongst the three groups. Urinary summary and pad usage scores showed no significant differences. Conclusion. RPP, RRP, and RALP offer similar surgical and QOL outcomes. RALP and RPP demonstrate less EBL compared to RRP.

  19. Kiam bestoj parolas

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Ofte oni bezonas scii, kiel nomi la "lingvajon" de la bestoj... sed mankas vortoj! Jen listo dekelkaj utilaj onomatopeoj. cu eble vi scias pri pliaj, kiujn ni povus aldoni al gi? Skribu al laredakcio!

  20. On the origin of near-infrared extragalactic background light anisotropy.

    Science.gov (United States)

    Zemcov, Michael; Smidt, Joseph; Arai, Toshiaki; Bock, James; Cooray, Asantha; Gong, Yan; Kim, Min Gyu; Korngut, Phillip; Lam, Anson; Lee, Dae Hee; Matsumoto, Toshio; Matsuura, Shuji; Nam, Uk Won; Roudier, Gael; Tsumura, Kohji; Wada, Takehiko

    2014-11-07

    Extragalactic background light (EBL) anisotropy traces variations in the total production of photons over cosmic history and may contain faint, extended components missed in galaxy point-source surveys. Infrared EBL fluctuations have been attributed to primordial galaxies and black holes at the epoch of reionization (EOR) or, alternately, intrahalo light (IHL) from stars tidally stripped from their parent galaxies at low redshift. We report new EBL anisotropy measurements from a specialized sounding rocket experiment at 1.1 and 1.6 micrometers. The observed fluctuations exceed the amplitude from known galaxy populations, are inconsistent with EOR galaxies and black holes, and are largely explained by IHL emission. The measured fluctuations are associated with an EBL intensity that is comparable to the background from known galaxies measured through number counts and therefore a substantial contribution to the energy contained in photons in the cosmos.

  1. Sickle cell trait is not associated with endemic Burkitt lymphoma: An ethnicity and malaria endemicity‐matched case–control study suggests factors controlling EBV may serve as a predictive biomarker for this pediatric cancer

    National Research Council Canada - National Science Library

    Mulama, David H; Bailey, Jeffrey A; Foley, Joslyn; Chelimo, Kiprotich; Ouma, Collins; Jura, Walter G.Z.O; Otieno, Juliana; Vulule, John; Moormann, Ann M

    2014-01-01

    ... to as “the protective hypothesis.” Past studies attempting to link sickle cell trait (HbAS), which is known to be protective against malaria, with protection from eBL were contradictory and underpowered...

  2. Explanation-based learning of data oriented parsing

    CERN Document Server

    Simaan, K

    1997-01-01

    This paper presents a new view of Explanation-Based Learning (EBL) of natural language parsing. Rather than employing EBL for specializing parsers by inferring new ones, this paper suggests employing EBL for learning how to reduce ambiguity only partially. The present method consists of an EBL algorithm for learning partial-parsers, and a parsing algorithm which combines partial-parsers with existing ``full-parsers". The learned partial-parsers, implementable as Cascades of Finite State Transducers (CFSTs), recognize and combine constituents efficiently, prohibiting spurious overgeneration. The parsing algorithm combines a learned partial-parser with a given full-parser such that the role of the full-parser is limited to combining the constituents, recognized by the partial-parser, and to recognizing unrecognized portions of the input sentence. Besides the reduction of the parse-space prior to disambiguation, the present method provides a way for refining existing disambiguation models that learn stochastic g...

  3. Secondary prophylaxis for esophageal variceal bleeding.

    Science.gov (United States)

    Albillos, Agustín; Tejedor, Marta

    2014-05-01

    Combination therapy with beta-blockers and endoscopic band ligation (EBL) is the standard prophylaxis of esophageal variceal rebleeding in cirrhosis. Beta-blockers are the backbone of combination therapy, since their benefit extend to other complications of portal hypertension. EBL carries the risk of post-banding ulcer bleeding, which explains why overall rebleeding is reduced when beta-blockers are added to EBL, and not when EBL is added to beta-blockers. TIPS is the rescue treatment, but it could be considered as first choice in patients that first bleed while on beta-blockers, those with contraindications to beta-blockers or with refractory ascites, and those with fundal varices.

  4. Detection of monoclonal integration of bovine leukemia virus proviral DNA as a malignant marker in two enzootic bovine leukosis cases with difficult clinical diagnosis.

    Science.gov (United States)

    Miura, Saori; Horiuchi, Noriyuki; Matsumoto, Kotaro; Kobayashi, Yoshiyasu; Kawazu, Shin-Ichiro; Inokuma, Hisashi

    2015-07-01

    Monoclonal integration of bovine leukemia virus (BLV) proviral DNA into bovine genomes was detected in peripheral blood from two clinical cases of enzootic bovine leukosis (EBL) without enlargement of superficial lymph nodes. A BLV-specific probe hybridized with 1 to 3 EcoRI and HindIII fragments in these 2 atypical EBL cattle by Southern blotting and hybridization, as well as in 3 typical EBL cattle. The probe also hybridized to a large number of EcoRI and HindIII fragments in 5 cattle with persistent leukosis. These results suggest that the detection of monoclonal integration of BLV provirus into the host genome may serve as a marker of monoclonal proliferation and malignancy in difficult to diagnose EBL cattle.

  5. A low density of the extragalactic background light revealed by the H.E.S.S. spectra of the BL Lac objects 1ES 1101-232 and H 2356-309

    Science.gov (United States)

    Costamante, Luigi

    2007-06-01

    The study of the TeV emission from extragalactic sources is hindered by the uncertainties on the diffuse Extragalactic Background Light (EBL). The recent H.E.S.S. results on the blazars 1ES 1101-232 and H 2356-309 represent a breakthrough on this issue. Their unexpectedly hard spectra allow an upper limit to be derived on the EBL in the optical/near-infrared range, which is very close to the lower limit given by the resolved galaxy counts. This result seems to exclude a large contribution to the EBL from other sources (e.g. Population III stars) and indicates that the intergalactic space is more transparent to γ-rays than previously thought. A discussion of EBL absorption effects and further observational tests with Cherenkov telescopes are presented.

  6. Observations of 1ES 1101-232 with H.E.S.S. and at lower frequencies: A hard spectrum blazar and constraints on the extragalactic background light

    Science.gov (United States)

    Pühlhofer, Gerd; Benbow, Wystan; Costamante, Luigi; Sol, Helene; Boisson, Catherine; Emmanoulopoulos, Dimitrios; Wagner, Stefan; Horns, Dieter; Giebels, Berrie

    VHE observations of the distant (z=0.186) blazar 1ES 1101-232 with H.E.S.S. are used to constrain the extragalactic background light (EBL) in the optical to near infrared band. As the EBL traces the galaxy formation history of the universe, galaxy evolution models can therefore be tested with the data. In order to measure the EBL absorption effect on a blazar spectrum, we assume that usual constraints on the hardness of the intrinsic blazar spectrum are not violated. We present an update of the VHE spectrum obtained with H.E.S.S. and the multifrequency data that were taken simultaneously with the H.E.S.S. measurements. The data verify that the broadband characteristics of 1ES 1101-232 are similar to those of other, more nearby blazars, and strengthen the assumptions that were used to derive the EBL upper limit.

  7. Plasmodium falciparum field isolates from South America use an atypical red blood cell invasion pathway associated with invasion ligand polymorphisms

    DEFF Research Database (Denmark)

    Lopez-Perez, Mary; Villasis, Elizabeth; Machado, Ricardo L D

    2012-01-01

    Studies of Plasmodium falciparum invasion pathways in field isolates have been limited. Red blood cell (RBC) invasion is a complex process involving two invasion protein families; Erythrocyte Binding-Like (EBL) and the Reticulocyte Binding-Like (PfRh) proteins, which are polymorphic and not fully...... characterized in field isolates. To determine the various P. falciparum invasion pathways used by parasite isolates from South America, we studied the invasion phenotypes in three regions: Colombia, Peru and Brazil. Additionally, polymorphisms in three members of the EBL (EBA-181, EBA-175 and EBL-1) and five......, the PfRh5 variant 1 and EBA-181 RVNKN variant. The ebl and Pfrh expression levels in a field isolate displaying the NrTrCr profile also pointed to PfRh2a, PfRh5 and EBA-181 as being possibly the major players in this invasion pathway. Notably, our studies demonstrate the uniqueness of the Peruvian P...

  8. Endoscopic band ligation for bleeding lesions in the small bowel

    Institute of Scientific and Technical Information of China (English)

    Takashi; Ikeya; Naoki; Ishii; Yuto; Shimamura; Kaoru; Nakano; Mai; Ego; Kenji; Nakamura; Koichi; Takagi; Katsuyuki; Fukuda; Yoshiyuki; Fujita

    2014-01-01

    AIM: To investigate the safety and efficacy of endo-scopic band ligation(EBL) for bleeding lesions in the small bowel.METHODS: This is a retrospective study evaluating EBL in six consecutive patients(three males, three fe-males, 46-86 years of age) treated between May 2009 and February 2014: duodenal vascular ectasia; 1, je-junal bleeding diverticulum; 1, ileal Dieulafoy’s lesion; 1 and ileal bleeding diverticula; 3. The success of the initial hemostasis was evaluated, and patients were observed for early rebleeding(within 30 d after EBL), and complications such as perforation and abscess for-mation. Follow-up endoscopies were performed in four patients.RESULTS: Initial hemostasis was successfully achieved with EBL in all six patients. Eversion was not sufficient in four diverticular lesions. Early rebleeding occurred three days after EBL in one ileal diverticulum, and arepeat endoscopy revealed dislodgement of the O-band and ulcer formation at the banded site. This rebleeding was managed conservatively. Late rebleeding occurred in this case(13 and 21 mo after initial EBL), and re-EBL was performed. Follow-up endoscopies revealed scar formation and the disappearance of vascular lesions at the banded site in the case with a duodenal bleeding lesion, and unresolved ileal diverticula in three cases. Surgery or transarterial embolization was not required without any complications during the median follow-up period of 45(range, 2-83) mo.CONCLUSION: EBL is a safe and effective endoscopic treatment for hemostasis of bleeding lesions in the small bowel.

  9. Some Novel Applications of Explanation-Based Learning to Parsing Lexicalized Tree-Adjoining Grammars

    CERN Document Server

    Srinivas, B; Joshi, Aravind

    1995-01-01

    In this paper we present some novel applications of Explanation-Based Learning (EBL) technique to parsing Lexicalized Tree-Adjoining grammars. The novel aspects are (a) immediate generalization of parses in the training set, (b) generalization over recursive structures and (c) representation of generalized parses as Finite State Transducers. A highly impoverished parser called a ``stapler'' has also been introduced. We present experimental results using EBL for different corpora and architectures to show the effectiveness of our approach.

  10. Using knowledge management practices to develop a state-of-the-art digital library.

    Science.gov (United States)

    Williams, Annette M; Giuse, Nunzia Bettinsoli; Koonce, Taneya Y; Kou, Qinghua; Giuse, Dario A

    2004-01-01

    Diffusing knowledge management practices within an organization encourages and facilitates reuse of the institution's knowledge commodity. Following knowledge management practices, the Eskind Biomedical Library (EBL) has created a Digital Library that uses a holistic approach for integration of information and skills to best represent both explicit and tacit knowledge inherent in libraries. EBL's Digital Library exemplifies a clear attempt to organize institutional knowledge in the field of librarianship, in an effort to positively impact clinical, research, and educational processes in the medical center.

  11. Comparisonof GaN-Based Light-Emitting Diodes by Using the AlGaN Electron-Blocking Layer and InAIN Electron-Blocking Layer

    Institute of Scientific and Technical Information of China (English)

    陈峻; 范广涵; 庞玮; 郑树文

    2011-01-01

    Optical properties of GaN-based light-emitting diodes(LEDs)are studied numerically by using AlGaN and InAIN electron-blocking layers(EBLs).Through the simulations of emission spectra,carrier concentration distribution,energy band,electrostatic field,internal quantum efficiency and output power,the results show that the LEDs with design of the InAIN EBL structure have a better performance over the original LEDs using an AlGaN EBL.The spectrum intensity and output power are enhanced significantly,and the efficiency droop of internal quantum efficiency is improved effectively with this design of InAlN EBL structure.It is proved that the strengths of carrier confinement and electron leakage current play a critical role in the performance of luminescence in LEDs.%Optical properties of GaN-based light-emitting diodes (LEDs) are studied numerically by using AlGaN and InAIN electron-blocking layers (EBLs). Through the simulations of emission spectra, carrier concentration distribution, energy band, electrostatic Reid, internal quantum efficiency and output power, the results show that the LEDs with design of the InAIN EBL structure have a better performance over the original LEDs using an AlGaN EBL. The spectrum intensity and output power are enhanced significantly, and the efficiency droop of internal quantum efficiency is improved effectively with this design of InAIN EBL structure. It is proved that the strengths of carrier confinement and electron leakage current play a critical role in tie performance of luminescence in LEDs.

  12. Developing the enquiring student and enhancing the research-teaching interface: student-led pedagogical research and educational initiatives in enquiry based learning

    OpenAIRE

    Pritchard, J.; Matthew, B.; Tierney, A.; Mackenzie, J.; STORCK, L.; Thomson, K.; Hood, A; Carroll, J; Crothers, A.; Wisbey, J.; Fletcher, M.; Hope, D; Morrow, L; Bridges, M.; Blanton, W.

    2008-01-01

    This paper describes the progress of a project running at the University of Glasgow to develop elements of Enquiry Based Learning (EBL) in undergraduate degree courses across a range of disciplines. It focuses on the second part of the project but an overview of the first part is also given. During phase 1 of the project, in the summer of 2007, seven undergraduate students spent four weeks working together exploring enquiry based learning (EBL) in the institution’s central, educational develo...

  13. The Extragalactic Background Light and the Gamma-ray Opacity of the Universe

    Science.gov (United States)

    Dwek, Eli; Krennrich, Frank

    2012-01-01

    The extragalactic background light (EBL) is one of the fundamental observational quantities in cosmology. All energy releases from resolved and unresolved extragalactic sources, and the light from any truly diffuse background, excluding the cosmic microwave background (CMB), contribute to its intensity and spectral energy distribution. It therefore plays a crucial role in cosmological tests for the formation and evolution of stellar objects and galaxies, and for setting limits on exotic energy releases in the universe. The EBL also plays an important role in the propagation of very high energy gamma-rays which are attenuated en route to Earth by pair producing gamma-gamma interactions with the EBL and CMB. The EBL affects the spectrum of the sources, predominantly blazars, in the approx 10 GeV to 10 TeV energy regime. Knowledge of the EBL intensity and spectrum will allow the determination of the intrinsic blazar spectrum in a crucial energy regime that can be used to test particle acceleration mechanisms and VHE gamma-ray production models. Conversely, knowledge of the intrinsic gamma-ray spectrum and the detection of blazars at increasingly higher redshifts will set strong limits on the EBL and its evolution. This paper reviews the latest developments in the determination of the EBL and its impact on the current understanding of the origin and production mechanisms of gamma-rays in blazars, and on energy releases in the universe. The review concludes with a summary and future directions in Cherenkov Telescope Array techniques and in infrared ground-based and space observatories that will greatly improve our knowledge of the EBL and the origin and production of very high energy gamma-rays.

  14. Systematic comparison of MRI findings in pediatric ependymoblastoma with ependymoma and CNS primitive neuroectodermal tumor not otherwise specified.

    Science.gov (United States)

    Nowak, Johannes; Seidel, Carolin; Pietsch, Torsten; Alkonyi, Balint; Fuss, Taylor Laura; Friedrich, Carsten; von Hoff, Katja; Rutkowski, Stefan; Warmuth-Metz, Monika

    2015-08-01

    Ependymoblastoma (EBL), ependymoma (EP), and primitive neuroectodermal tumors of the central nervous system not otherwise specified (CNS-PNET NOS) are pediatric brain tumors that can be differentiated by histopathology in the clinical setting. Recently, we described specific MRI features of EBL. In this study, we compare standardized MRI characteristics of EBL with EP and CNS-PNET NOS in a series comprising 22 patients in each group. All 66 centrally reviewed cases were obtained from the database of the German multicenter HIT trials. We systematically analyzed the initial MRI scans at diagnosis according to standardized criteria, and paired comparison was performed for EBL and EP, as well as for EBL and CNS-PNET NOS. We found differences between EBL and EP regarding age at diagnosis, MR signal intensity, tumor margin and surrounding edema, presence and size of cysts, and contrast enhancement pattern. Although MRI appearance of EBL shares many features with CNS-PNET NOS, we revealed significant differences in terms of age at diagnosis, tumor volume and localization, tumor margins, edema, and contrast enhancement. This is the first study that systematically compares multiple parameters of MRI in pediatric EBL with findings in EP and CNS-PNET NOS. Although a definite differentiation by means of MRI alone might not be feasible in the individual case, we identify significant differences between these tumor entities. © The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  15. Preoperative embolization in carotid body tumor surgery: is it required?

    Science.gov (United States)

    Zeitler, Daniel M; Glick, Joelle; Har-El, Gady

    2010-05-01

    We compared estimated blood loss (EBL) in patients who underwent surgical excision of carotid body tumors (CBTs) after preoperative superselective angiography with embolization (PSE) with that in patients who underwent excision of CBTs without PSE. We performed a retrospective chart review of a consecutive case series in a single surgeon's practice within an academic tertiary care medical center. Twenty-five patients underwent surgical resection of a CBT from 1989 to 2009. From 1989 to 1996, 10 consecutive patients had PSE of the CBT, whereas the subsequent 15 patients (1996 to 2009) had no PSE. Demographic data including age, sex, and tumor size were collected. The EBL was obtained from intraoperative records and operative notes dictated at the time of surgery. Tumor size was based on preoperative radiographic measurements by a senior radiologist and the surgeon. In the 10 patients with PSE, the mean age was 41 years (range, 22 to 72 years) and the mean tumor size was 4.8 cm (range, 2.9 to 8.3 cm). The mean EBL was 305 mL (range, 50 to 1,000 mL); 2 patients had an EBL of more than 400 mL. In the 15 patients without PSE, the mean age was 43.7 years (range, 20 to 75 years) and the mean tumor size was 4.4 cm (range, 2.8 to 7.9 cm). The mean EBL was 265.6 mL (range, 40 to 900 mL); 2 patients had an EBL of more than 400 mL. There were no significant differences between the 2 groups with regard to age, tumor size, or EBL. Preoperative superselective angiography with embolization of a CBT does not lead to a significant reduction in intraoperative EBL.

  16. Nanopillar Photonic Crystal Lasers for Tb/s Transceivers on Silicon

    Science.gov (United States)

    2015-07-09

    thermal silicon dioxide (SiO2). Next, E-Beam resist ZEP520A was coated and nanoholes were patterned by E-Beam lithography ( EBL ). The designed diameter...and pitch of nanoholes for EBL patterning are 80 nm and 800 nm, respectively, and the size of the array is 50 μm × 50 μm. The SiNx layer was etched

  17. Antifibrinolytic agents reduce blood loss during pediatric vertebral column resection procedures.

    Science.gov (United States)

    Newton, Peter O; Bastrom, Tracey P; Emans, John B; Shah, Suken A; Shufflebarger, Harry L; Sponseller, Paul D; Sucato, Daniel J; Lenke, Lawrence G

    2012-11-01

    Retrospective multicenter review. To evaluate the effect of intraoperative antifibrinolytic (AF) agents on blood loss associated with vertebral column resection (VCR) procedures for pediatric patients. VCR procedures may be associated with substantial blood loss. A multicenter review of 147 patients (aged EBL) was calculated as percentage of blood volume (BV) (EBL/BV × 100), which was normalized on the basis of the number of vertebral levels removed (%BV/level). The use of AF agents was noted (tranexamic acid [TXA], aminocaproic acid, aprotinin, none) and based on surgeons' choice. EBL was compared using analysis of covariance (controlling for deformity magnitude) (P EBL averaged 1317 mL (range, 50-6026 mL). Eleven patients were excluded: 7 with incomplete data and 4 who received aminocaproic acid (too few to compare). This resulted in 136 cases; 64 with no AF, 42 received TXA, and 30 received aprotinin. Overall %BV/level EBL was 41% ± 39% (range, 6%-162%) and was significantly higher in the no-AF group (52% ± 37%) than the TXA (30% ± 34%; P EBL associated with VCR was highly variable and in many cases exceeded the patient's BV. AF agents were not routinely used and we had insufficient data to assess the efficacy of aminocaproic acid. Both aprotinin and TXA resulted in less EBL than when no AF was used; however, the effect of the reduction varied by site. Aprotinin has since been removed from the market. When normalized to patient size and levels excised, the use of TXA resulted in a reduction in intraoperative EBL.

  18. Exogenous application of brassinosteroid offers tolerance to salinity by altering stress responses in rice variety Pusa Basmati-1.

    Science.gov (United States)

    Sharma, Isha; Ching, Erwan; Saini, Shivani; Bhardwaj, Renu; Pati, Pratap Kumar

    2013-08-01

    Plant steroidal hormones, brassinosteroids, play a pivotal role in variety of plant developmental processes and adaptation to various environmental stresses. The present work investigates the response of various stress markers upon exogenous application of 24-epibrassinolide (EBL) on Pusa Basmati-1, a commercially important rice variety, under salt stress conditions. Rice seeds after treatment with different concentrations of NaCl alone or in combination with different concentrations of 24-epibrassinolide (EBL) were analysed for various growth parameters, protein, proline and malondialdehyde content (MDA) and antioxidant enzymes activities. The seedlings exposed to NaCl exhibited a significant decline in growth parameters and changes in the levels of antioxidant enzymes, however, treatment with EBL showed an improvement in growth, levels of protein and proline content and antioxidant enzymes activity. The enhanced levels of MDA content during salt stress in rice seedlings was decreased with EBL treatment. Further, the treatment with EBL increased the expression of various oxidative stress marker genes, although to different levels. Expression of various brassinosteroids (OsBRI1, OsDWF4) and salt (SalT) responsive genes, revealed the down regulation of OsDWF4 with application of EBL and upregulation of SalT in presence of salt stress thereby confirming the efficacy of the treatments. Interestingly, a significant down regulation of SalT gene was observed on application of EBL along with salt compared to salt treatment alone. On the other hand, the application of EBL alone and in combination with salt has resulted in upregulation of OsBRI1. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  19. Fabrication and Characterization of Single Doped GaAs Nanowire Devices

    OpenAIRE

    Nordeng, Mikael Johannes

    2011-01-01

    In the work with this master thesis, electron beam lithography (EBL) and other cleanroom methods was used to develop a reproducible process for making ohmic contactsto nanowires (NWs), with the aim of investigating different dopants’ influence ontheir physical properties. After optimizing the EBL process, good alignment of thecontact patterns to the NWs was achieved by doing a thorough alignment procedure.A detailed write field alignment close to the sample position prior to the 3-point ...

  20. Effects of 24-epibrassinolide on the photosynthetic characteristics, antioxidant system, and chloroplast ultrastructure in Cucumis sativus L. under Ca(NO(3))(2) stress.

    Science.gov (United States)

    Yuan, Lingyun; Shu, Sheng; Sun, Jin; Guo, Shirong; Tezuka, Takafumi

    2012-09-01

    The effects of 0.1 μM 24-epibrassinolide (EBL) on plant growth (plant height, leaf area, fresh weight, and dry weight), chlorophyll content, photosynthetic characteristics, antioxidant enzymes, and chloroplast ultrastructure were investigated using cucumber seedlings (Cucumis sativus L. cv. Jinyou No. 4) with 80 mM Ca(NO(3))(2) to induce stress. The presence of Ca(NO(3))(2) caused significant reductions in net photosynthetic rate (P(N)), stomatal conductance (Gs), intercellular CO(2) concentration (Ci), and transpiration rate (Tr) of leaves. In addition, Ca(NO(3))(2) markedly reduced the chlorophyll content and inhibited photochemical activity, including the actual photochemical efficiency (ΦPSII). In contrast, EBL increased the chlorophyll content, especially chlorophyll b, and minimized the harmful effects on photosynthesis caused by the Ca(NO(3))(2). The application of EBL to the plants subjected to Ca(NO(3))(2)-enhanced photochemical activity. EBL protected the photosynthetic membrane system from oxidative damage due to up-regulating the capacity of the antioxidant systems. Microscopic analyses revealed that Ca(NO(3))(2) affected the structure of the photosynthetic apparatus and membrane system and induced damage of granal thylakoid layers, while EBL recovered the typical shape of chloroplasts and promoted the formation of grana. Taken together, EBL compensated for damage/losses by Ca(NO(3))(2) due to the regulation of photosynthetic characteristics and the antioxidant system.

  1. Measurement of the extragalactic background light imprint on the spectra of the brightest blazars observed with H.E.S.S.

    Science.gov (United States)

    H.E.S.S. Collaboration; Abramowski, A.; Acero, F.; Aharonian, F.; Akhperjanian, A. G.; Anton, G.; Balenderan, S.; Balzer, A.; Barnacka, A.; Becherini, Y.; Becker Tjus, J.; Bernlöhr, K.; Birsin, E.; Biteau, J.; Bochow, A.; Boisson, C.; Bolmont, J.; Bordas, P.; Brucker, J.; Brun, F.; Brun, P.; Bulik, T.; Carrigan, S.; Casanova, S.; Cerruti, M.; Chadwick, P. M.; Charbonnier, A.; Chaves, R. C. G.; Cheesebrough, A.; Cologna, G.; Conrad, J.; Couturier, C.; Dalton, M.; Daniel, M. K.; Davids, I. D.; Degrange, B.; Deil, C.; deWilt, P.; Dickinson, H. J.; Djannati-Ataï, A.; Domainko, W.; O'C. Drury, L.; Dubus, G.; Dutson, K.; Dyks, J.; Dyrda, M.; Egberts, K.; Eger, P.; Espigat, P.; Fallon, L.; Farnier, C.; Fegan, S.; Feinstein, F.; Fernandes, M. V.; Fernandez, D.; Fiasson, A.; Fontaine, G.; Förster, A.; Füßling, M.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Gast, H.; Giebels, B.; Glicenstein, J. F.; Glück, B.; Göring, D.; Grondin, M.-H.; Häffner, S.; Hague, J. D.; Hahn, J.; Hampf, D.; Harris, J.; Heinz, S.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hillert, A.; Hinton, J. A.; Hofmann, W.; Hofverberg, P.; Holler, M.; Horns, D.; Jacholkowska, A.; Jahn, C.; Jamrozy, M.; Jung, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kaufmann, S.; Khélifi, B.; Klochkov, D.; Kluźniak, W.; Kneiske, T.; Komin, Nu.; Kosack, K.; Kossakowski, R.; Krayzel, F.; Laffon, H.; Lamanna, G.; Lenain, J.-P.; Lennarz, D.; Lohse, T.; Lopatin, A.; Lu, C.-C.; Marandon, V.; Marcowith, A.; Masbou, J.; Maurin, G.; Maxted, N.; Mayer, M.; McComb, T. J. L.; Medina, M. C.; Méhault, J.; Menzler, U.; Moderski, R.; Mohamed, M.; Moulin, E.; Naumann, C. L.; Naumann-Godo, M.; de Naurois, M.; Nedbal, D.; Nguyen, N.; Niemiec, J.; Nolan, S. J.; Ohm, S.; de Oña Wilhelmi, E.; Opitz, B.; Ostrowski, M.; Oya, I.; Panter, M.; Parsons, D.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perez, J.; Petrucci, P.-O.; Peyaud, B.; Pita, S.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raue, M.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Ripken, J.; Rob, L.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Sanchez, D. A.; Santangelo, A.; Schlickeiser, R.; Schulz, A.; Schwanke, U.; Schwarzburg, S.; Schwemmer, S.; Sheidaei, F.; Skilton, J. L.; Sol, H.; Spengler, G.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Szostek, A.; Tavernet, J.-P.; Terrier, R.; Tluczykont, M.; Valerius, K.; van Eldik, C.; Vasileiadis, G.; Venter, C.; Viana, A.; Vincent, P.; Völk, H. J.; Volpe, F.; Vorobiov, S.; Vorster, M.; Wagner, S. J.; Ward, M.; White, R.; Wierzcholska, A.; Wouters, D.; Zacharias, M.; Zajczyk, A.; Zdziarski, A. A.; Zech, A.; Zechlin, H.-S.

    2013-02-01

    The extragalactic background light (EBL) is the diffuse radiation with the second highest energy density in the Universe after the cosmic microwave background. The aim of this study is the measurement of the imprint of the EBL opacity to γ-rays on the spectra of the brightest extragalactic sources detected with the High Energy Stereoscopic System (H.E.S.S.). The originality of the method lies in the joint fit of the EBL optical depth and of the intrinsic spectra of the sources, assuming intrinsic smoothness. Analysis of a total of ~105γ-ray events enables the detection of an EBL signature at the 8.8σ level and constitutes the first measurement of the EBL optical depth using very-high energy (E > 100 GeV) γ-rays. The EBL flux density is constrained over almost two decades of wavelengths [0.30 μm, 17 μm] and the peak value at 1.4 μm is derived as λFλ = 15 ± 2stat ± 3sys nW m-2 sr-1. Appendix A is available in electronic form at http://www.aanda.org

  2. Measurement of the extragalactic background light imprint on the spectra of the brightest blazars observed with H.E.S.S

    CERN Document Server

    :,; Acero, F; Aharonian, F; Akhperjanian, A G; Anton, G; Balenderan, S; Balzer, A; Barnacka, A; Becherini, Y; Tjus, J Becker; Bernlöhr, K; Birsin, E; Biteau, J; Bochow, A; Boisson, C; Bolmont, J; Bordas, P; Brucker, J; Brun, F; Brun, P; Bulik, T; Carrigan, S; Casanova, S; Cerruti, M; Chadwick, P M; Charbonnier, A; Chaves, R C G; Cheesebrough, A; Cologna, G; Conrad, J; Couturier, C; Dalton, M; Daniel, M K; Davids, I D; Degrange, B; Deil, C; deWilt, P; Dickinson, H J; Djannati-Ataï, A; Domainko, W; Drury, L O'C; Dubus, G; Dutson, K; Dyks, J; Dyrda, M; Egberts, K; Eger, P; Espigat, P; Fallon, L; Farnier, C; Fegan, S; Feinstein, F; Fernandes, M V; Fernandez, D; Fiasson, A; Fontaine, G; Förster, A; Füßling, M; Gajdus, M; Gallant, Y A; Garrigoux, T; Gast, H; Giebels, B; Glicenstein, J F; Glück, B; Göring, D; Grondin, M -H; Häffner, S; Hague, J D; Hahn, J; Hampf, D; Harris, J; Heinz, S; Heinzelmann, G; Henri, G; Hermann, G; Hillert, A; Hinton, J A; Hofmann, W; Hofverberg, P; Holler, M; Horns, D; Jacholkowska, A; Jahn, C; Jamrozy, M; Jung, I; Kastendieck, M A; Katarzyński, K; Katz, U; Kaufmann, S; Khélifi, B; Klochkov, D; Kluźniak, W; Kneiske, T; Komin, Nu; Kosack, K; Kossakowski, R; Krayzel, F; Laffon, H; Lamanna, G; Lenain, J -P; Lennarz, D; Lohse, T; Lopatin, A; Lu, C -C; Marandon, V; Marcowith, A; Masbou, J; Maurin, G; Maxted, N; Mayer, M; McComb, T J L; Medina, M C; Méhault, J; Menzler, U; Moderski, R; Mohamed, M; Moulin, E; Naumann, C L; Naumann-Godo, M; de Naurois, M; Nedbal, D; Nguyen, N; Niemiec, J; Nolan, S J; Ohm, S; Wilhelmi, E de Oña; Opitz, B; Ostrowski, M; Oya, I; Panter, M; Parsons, D; Arribas, M Paz; Pekeur, N W; Pelletier, G; Perez, J; Petrucci, P -O; Peyaud, B; Pita, S; Pühlhofer, G; Punch, M; Quirrenbach, A; Raue, M; Reimer, A; Reimer, O; Renaud, M; Reyes, R de los; Rieger, F; Ripken, J; Rob, L; Rosier-Lees, S; Rowell, G; Rudak, B; Rulten, C B; Sahakian, V; Sanchez, D A; Santangelo, A; Schlickeiser, R; Schulz, A; Schwanke, U; Schwarzburg, S; Schwemmer, S; Sheidaei, F; Skilton, J L; Sol, H; Spengler, G; Stawarz, Ł; Steenkamp, R; Stegmann, C; Stinzing, F; Stycz, K; Sushch, I; Szostek, A; Tavernet, J -P; Terrier, R; Tluczykont, M; Valerius, K; van Eldik, C; Vasileiadis, G; Venter, C; Viana, A; Vincent, P; Völk, H J; Volpe, F; Vorobiov, S; Vorster, M; Wagner, S J; Ward, M; White, R; Wierzcholska, A; Wouters, D; Zacharias, M; Zajczyk, A; Zdziarski, A A; Zech, A; Zechlin, H -S

    2012-01-01

    The extragalactic background light (EBL) is the diffuse radiation with the second highest energy density in the Universe after the cosmic microwave background. The aim of this study is the measurement of the imprint of the EBL opacity to gamma-rays on the spectra of the brightest extragalactic sources detected with the High Energy Stereoscopic System (H.E.S.S.). The originality of the method lies in the joint fit of the EBL optical depth and of the intrinsic spectra of the sources, assuming intrinsic smoothness. Analysis of a total of ~10^5 gamma-ray events enables the detection of an EBL signature at the 8.8 std dev level and constitutes the first measurement of the EBL optical depth using very-high energy (E>100 GeV) gamma-rays. The EBL flux density is constrained over almost two decades of wavelengths (0.30-17 microns) and the peak value at 1.4 micron is derived as 15 +/- 2 (stat) +/- 3 (sys) nW / m^2 sr.

  3. Probing the peak of the star formation rate density with the extragalactic background light

    CERN Document Server

    Raue, Martin

    2012-01-01

    The extragalactic background light (EBL), i.e., the diffuse meta-galactic photon field in the ultraviolet to infrared, is dominated by the emission from stars in galaxies. It is, therefore, intimately connected with the integrated star formation rate density (SFRD). In this paper, the SFRD is constrained using recent limits on the EBL density derived from observations of distant sources of high and very-high energy gamma-rays. The stellar EBL contribution is modeled utilizing simple stellar population spectra including dust attenuation and emission. A wide range of values for the different model parameters (SFRD(z), metallicity, dust absorption) is investigated and their impact on the resulting EBL is studied. The calculated EBL densities are compared with the specific EBL density limits and constraints on the SFRD are derived. For the fiducial model, adopting a Chabrier initial mass function (IMF), the SFRD is constrained to ~< 0.1 M_solar yr^-1 Mpc^-3 and < 0.2 M_solar yr^-1 Mpc^-3 for a redshift of z...

  4. High-performance InGaN-based green light-emitting diodes with quaternary InAlGaN/GaN superlattice electron blocking layer.

    Science.gov (United States)

    Tzou, An-Jye; Lin, Da-Wei; Yu, Chien-Rong; Li, Zhen-Yu; Liao, Yu-Kuang; Lin, Bing-Cheng; Huang, Jhih-Kai; Lin, Chien-Chung; Kao, Tsung Sheng; Kuo, Hao-Chung; Chang, Chun-Yen

    2016-05-30

    In this study, high-performance InGaN-based green light-emitting diodes (LEDs) with a quaternary InAlGaN/GaN superlattice electron blocking layer (QSL-EBL) have been demonstrated. The band structural simulation was employed to investigate the electrostatic field and carriers distribution, show that the efficiency and droop behavior can be intensively improved by using a QSL-EBL in LEDs. The QSL-EBL structure can reduce the polarization-related electrostatic fields in the multiple quantum wells (MQWs), leading to a smoother band diagram and a more uniform carriers distribution among the quantum wells under forward bias. In comparison with green LEDs with conventional bulk-EBL structure, the light output power of LEDs with QSL-EBL was greatly enhanced by 53%. The efficiency droop shows only 30% at 100 A/cm2 comparing to its peak value, suggesting that the QSL-EBL LED is promising for future white lighting with high performance.

  5. Students' views of enquiry-based learning in a continuing professional development module.

    Science.gov (United States)

    Kirwan, Anne; Adams, John

    2009-05-01

    The purpose of this study was to explore whether qualified nurses who had undertaken a continuing professional development module at a UK university, which utilised enquiry-based learning (EBL) as the educational strategy, believed that their nursing practice had been influenced by this educational approach. This study was underpinned by the assumptions of Gadamerian hermeneutic phenomenology; semi-structured interviews were conducted with eight nurses who had undertaken a continuing education module utilising an EBL approach. The responses in this study indicate that participants believed that their practice of nursing had been positively influenced by engaging in EBL. They felt that by becoming self-directed, critical, reflective practitioners, they were better able to deliver evidence-based practice/care. Self reports of practice change attributed to engaging in EBL were provided, with the patient identified as the principal beneficiary, echoing the espoused aims of continuing professional development. EBL was credited with being a motivating, energizing and enjoyable way of learning but participants were critical of the lack of preparedness of both the students and facilitators. Consideration needs to given as to whether EBL is viewed as a philosophy of learning or as a facilitative strategy used alongside other educational methods.

  6. Regulatory roles of 24-epibrassinolide in tolerance of Acacia gerrardii Benth to salt stress.

    Science.gov (United States)

    Abd Allah, Elsayed Fathi; Alqarawi, A A; Hashem, Abeer; Wirth, Stephan; Egamberdieva, Dilfuza

    2017-07-11

    This experiment aimed to investigate the role of 24-epibrassinolide (EBL) against NaCl-induced salinity stress in Acacia gerrardii Benth. NaCl (200 mM) imparted deleterious effects on the growth and chlorophyll contents of A. gerrardii, but foliar application of EBL (1.0 mg/l; each plant received 2.5 ml) mitigated the negative effect considerably. NaCl reduced chlorophyll content but this was significantly ameliorated by the application of EBL. EBL reduced significantly NaCl-induced oxidative stress hence protect membranes and also improved the relative water content significantly by 6.6% as compared with control. Nitrate reductase activity declined after NaCl treatment but EBL application sustained its activity under normal and stressed conditions. Exogenous application of EBL significantly improved the activity of superoxide dismutase, catalase and the enzymes of the ascorbate-glutathione pathway thereby protecting the photosynthetic electron transport chain and other metabolic processes in A. gerrardii from NaCl-induced oxidative stress.

  7. Repair of an Endoscopic Retrograde Cholangiopancreatography-Related Large Duodenal Perforation Using Double Endoscopic Band Ligation and Endoclipping.

    Science.gov (United States)

    Kim, Keunmo; Kim, Eun Bee; Choi, Yong Hyeok; Oh, Youngmin; Han, Joung-Ho; Park, Seon Mee

    2017-03-01

    Endoscopic closure techniques have been introduced for the repair of duodenal wall perforations that occur during endoscopic retrograde cholangiopancreatography (ERCP). We report a case of successful repair of a large duodenal wall perforation by using double endoscopic band ligation (EBL) and an endoclip. Lateral duodenal wall perforation occurred during ERCP in a 93-year-old woman with acute calculous cholangitis. We switched to a forward endoscope that had a transparent band apparatus. A 2.0-cm oval-shaped perforation was found at the lateral duodenal wall. We repaired the perforation by sequentially performing double EBL and endoclipping. The first EBL was performed at the proximal edge of the perforation orifice, and two-thirds of the perforation were repaired. The second EBL, which also included the contents covered under the first EBL, repaired the defect almost completely. Finally, to account for the possible presence of a residual perforation, an endoclip was applied at the distal end of the perforation. The detection and closure of the perforation were completed within 10 minutes. We suggest that double EBL is an effective method for closure.

  8. Explanation-based learning in infancy.

    Science.gov (United States)

    Baillargeon, Renée; DeJong, Gerald F

    2017-07-11

    In explanation-based learning (EBL), domain knowledge is leveraged in order to learn general rules from few examples. An explanation is constructed for initial exemplars and is then generalized into a candidate rule that uses only the relevant features specified in the explanation; if the rule proves accurate for a few additional exemplars, it is adopted. EBL is thus highly efficient because it combines both analytic and empirical evidence. EBL has been proposed as one of the mechanisms that help infants acquire and revise their physical rules. To evaluate this proposal, 11- and 12-month-olds (n = 260) were taught to replace their current support rule (that an object is stable when half or more of its bottom surface is supported) with a more sophisticated rule (that an object is stable when half or more of the entire object is supported). Infants saw teaching events in which asymmetrical objects were placed on a base, followed by static test displays involving a novel asymmetrical object and a novel base. When the teaching events were designed to facilitate EBL, infants learned the new rule with as few as two (12-month-olds) or three (11-month-olds) exemplars. When the teaching events were designed to impede EBL, however, infants failed to learn the rule. Together, these results demonstrate that even infants, with their limited knowledge about the world, benefit from the knowledge-based approach of EBL.

  9. Changes in Cardiac Varices and Their Clinical Significance after Eradication of Esophageal Varices by Band Ligation

    Directory of Open Access Journals (Sweden)

    Seung Woon Park

    2016-01-01

    Full Text Available Background and Aims. Cardiac varices (CVs in patients with type 1 gastroesophageal varices (GOV1s usually disappear with treatment for esophageal varices (EVs by endoscopic injection sclerotherapy (EIS. However, whether this applies to patients treated with endoscopic band ligation (EBL for EVs remains unclear. We evaluated the effect of EVs eradication by EBL on CVs. Methods. We included cirrhotic patients whose EVs had been eradicated using EBL and excluded those who had been treated using EIS, those who had received endoscopic therapy for CVs, and those who were combined with hepatocellular carcinoma. Results. A total of 123 patients were enrolled. The age was 59.7 ± 11.7 years, and 96 patients (78.0% were men. Thirty-eight patients (30.9% had EVs only, while 85 (69.1% had GOV1s. After EVs eradication, the CVs disappeared in 55 patients (64.7%. EVs recurred in 40 patients, with recurrence rates at 1, 2, and 3 years of 16.0%, 29.6%, and 35.6%, respectively, the recurrence being more frequent in patients who had undergone EBL for secondary prophylaxis and in those with persisting CVs after EVs eradication (P=0.003. Conclusions. CVs frequently disappeared when EVs were eradicated using EBL in patients with GOV1s. Persistence of CVs after EVs eradication by EBL was associated with EVs recurrence.

  10. Fermi-LAT high-z active galactic nuclei and the extragalactic background light

    Science.gov (United States)

    Armstrong, Thomas; Brown, Anthony M.; Chadwick, Paula M.

    2017-10-01

    Observations of distant gamma-ray sources are hindered by the presence of the extragalactic background light (EBL). In order to understand the physical processes that result in the observed spectrum of sources, it is imperative that a good understanding of the EBL is included. In this work, an investigation into the imprint of the EBL on the observed spectra of high-redshift Fermi-LAT active galactic nuclei is presented. By fitting the spectrum below ˜10 GeV, an estimation of the unabsorbed intrinsic source spectrum is obtained; by applying this spectrum to data up to 300 GeV, it is then possible to derive a scaling factor for different EBL models. A second approach uses five sources (PKS 0426-380, 4C +55.17, Ton 116, PG 1246+586 and RBS 1432) that were found to exhibit very high energy (VHE) emission (Eγ > 100 GeV). Through Monte Carlo simulations, it is shown that the observation of VHE photons, despite the large distances of these objects, is consistent with current EBL models. Many of these sources would be observable with the upcoming ground-based observatory, the Cherenkov Telescope Array, leading to a better understanding of the EBL.

  11. Chromium stress mitigation by polyamine-brassinosteroid application involves phytohormonal and physiological strategies in Raphanus sativus L.

    Directory of Open Access Journals (Sweden)

    Sikander Pal Choudhary

    Full Text Available Brassinosteroids (BRs and polyamines (PAs are well-established growth regulators playing key roles in stress management among plants. In the present study, we evaluated the effects of epibrassinolide (EBL, an active BR and spermidine (Spd, an active PA on the tolerance of radish to oxidative stress induced by Cr (VI metal. Our investigation aimed to study the impacts of EBL (10(-9 M and/or Spd (1 mM on the biochemical and physiological responses of radish (Raphanus sativus L. under Cr-stress. Applications of EBL and/or Spd were found to improve growth of Cr-stressed seedlings in terms of root length, shoot length and fresh weight. Our data also indicated that applications of EBL and Spd have significant impacts, particularly when applied together, on the endogenous titers of PAs, free and bound forms of IAA and ABA in seedlings treated with Cr-stress. Additionally, co-applications of EBL and Spd modulated more remarkably the titers of antioxidants (glutathione, ascorbic acid, proline, glycine betaine and total phenol and activities of antioxidant enzymes (guaicol peroxidase, catalase, superoxide dismutase and glutathione reductase in Cr-stressed plants than their individual applications. Attenuation of Cr-stress by EBL and/or Spd (more efficient with EBL and Spd combination was also supported by enhanced values of stress indices, such as phytochelatins, photosynthetic pigments and total soluble sugars, and reduction in malondialdehyde and H(2O(2 levels in Cr-treated seedlings. Diminution of ROS production and enhanced ROS scavenging capacities were also noted for EBL and/or Spd under Cr-stress. However, no significant reduction in Cr uptake was observed for co-application of EBL and Spd when compared to their individual treatments in Cr-stressed seedlings. Taken together, our results demonstrate that co-applications of EBL and Spd are more effective than their independent treatments in lowering the Cr-induced oxidative stress in radish, leading

  12. Outcomes of endoscopic treatment of gastroduodenal Dieulafoy's lesion with rubber band ligation and thermal/injection therapy.

    Science.gov (United States)

    Mumtaz, Rushda; Shaukat, Masud; Ramirez, Francisco C

    2003-04-01

    Dieulafoy's lesion is a rare but important cause of upper gastrointestinal bleeding. Current endoscopic methods used to treat Dieulafoy's lesion include injection, with or without thermal methods, and mechanical methods. The latter include variceal ligation and hemoclips. There are no studies comparing the outcomes of rubber band ligation and injection with or without thermal therapy. To report the outcomes of Dieulafoy's lesion treated endoscopically with rubber band ligation and injection with or without thermal therapy at a single institution. Patients with the diagnosis of Dieulafoy's lesion treated endoscopically at the Carl T. Hayden VA Medical Center in Phoenix, between August 1994 and August 2002 were analyzed. Demographic data, mode of presentation, risk factors for gastrointestinal bleeding, hemodynamic parameters, blood transfusion requirements, endoscopic findings, details of endoscopic therapy, length of stay in ICU/hospital, complications, recurrence of bleeding, and mortality rates were collected and compared between those receiving endoscopic band ligation (EBL group) and those receiving injection with or without thermal therapy (non-EBL group). Twenty-three patients with Dieulafoy's lesion (14 in the EBL group and nine in the non-EBL group) were studied. All patients were men. The mean age, hemoglobin levels on admission, and the transfusion requirements before therapy were similar in both groups. Fourteen patients (eight in the EBL- and six in the non-EBL groups) presented with hematemesis and the remaining with melena. The majority of Dieulafoy's lesions (91.3%) were located in the stomach and two in the duodenum. Active bleeding at the time of endoscopy was seen in 61% of cases, and immediate hemostasis was achieved with either method in 100% of patients. Early rebleeding (within 72 hours of endoscopic therapy) occurred in only one patient treated with epinephrine plus heater probe therapy. The length of stay in ICU was longer in the non-EBL

  13. Chromium stress mitigation by polyamine-brassinosteroid application involves phytohormonal and physiological strategies in Raphanus sativus L.

    Science.gov (United States)

    Choudhary, Sikander Pal; Kanwar, Mukesh; Bhardwaj, Renu; Yu, Jing-Quan; Tran, Lam-Son Phan

    2012-01-01

    Brassinosteroids (BRs) and polyamines (PAs) are well-established growth regulators playing key roles in stress management among plants. In the present study, we evaluated the effects of epibrassinolide (EBL, an active BR) and spermidine (Spd, an active PA) on the tolerance of radish to oxidative stress induced by Cr (VI) metal. Our investigation aimed to study the impacts of EBL (10(-9) M) and/or Spd (1 mM) on the biochemical and physiological responses of radish (Raphanus sativus L.) under Cr-stress. Applications of EBL and/or Spd were found to improve growth of Cr-stressed seedlings in terms of root length, shoot length and fresh weight. Our data also indicated that applications of EBL and Spd have significant impacts, particularly when applied together, on the endogenous titers of PAs, free and bound forms of IAA and ABA in seedlings treated with Cr-stress. Additionally, co-applications of EBL and Spd modulated more remarkably the titers of antioxidants (glutathione, ascorbic acid, proline, glycine betaine and total phenol) and activities of antioxidant enzymes (guaicol peroxidase, catalase, superoxide dismutase and glutathione reductase) in Cr-stressed plants than their individual applications. Attenuation of Cr-stress by EBL and/or Spd (more efficient with EBL and Spd combination) was also supported by enhanced values of stress indices, such as phytochelatins, photosynthetic pigments and total soluble sugars, and reduction in malondialdehyde and H(2)O(2) levels in Cr-treated seedlings. Diminution of ROS production and enhanced ROS scavenging capacities were also noted for EBL and/or Spd under Cr-stress. However, no significant reduction in Cr uptake was observed for co-application of EBL and Spd when compared to their individual treatments in Cr-stressed seedlings. Taken together, our results demonstrate that co-applications of EBL and Spd are more effective than their independent treatments in lowering the Cr-induced oxidative stress in radish, leading to

  14. Quaternary ultraviolet AlInGaN MQW laser diode performance using quaternary AlInGaN electron blocking layer.

    Science.gov (United States)

    Ghazai, A J; Thahab, S M; Abu Hassan, H; Hassan, Z

    2011-05-09

    The effect of polarization-matched Al(0.25)In(0.08)Ga(0.67)N electron-blocking layer (EBL) on the optical performance of ultraviolet Al(0.08)In(0.08)Ga(0.84)N/Al(0.1)In(0.01)Ga(0.84)N multi-quantum well (MQW) laser diodes (LDs) was investigated. The polarization-matched Al(0.25)In(0.08)Ga(0.67)N electron blocking layer (EBL) was employed in an attempt to reduce the polarization effect inside the active region of the diodes. The device performance which is affected by piezoelectric was studied via drift-diffusion model for carrier transport, optical gain and losses using the simulation program of Integrated System Engineering Technical Computer Aided design (ISE TCAD). The optical performance of the LD using quaternary Al(0.25)In(0.08)Ga(0.67)N EBL was compared with the LD using ternary Al(0.3)Ga(0.7)N EBL where both materials have the same energy band gap of Eg = 3.53 eV. The self-consistent ISE-TCAD simulation program results showed that the polarization-matched quaternary Al(0.25)In(0.08)Ga(0.67)N EBL is beneficial as it confines the electrons inside the quantum well region better than ternary Al(0.3)Ga(0.7)N EBL. The results indicated that the use of Al(0.25)In(0.08)Ga(0.67)N EBL has lower threshold current and higher optical intensity than those for Al(0.3)Ga(0.7)N EBL. The effect of Al(0.25)In(0.08)Ga(0.67)N EBL thickness on the performance of LDs has also been studied. Results at room temperature indicated that lower threshold current, high slope efficiency, high output power, and high differential quantum efficiency DQE occurred when the thickness of Al(0.25)In(0.08)Ga(0.67)N EBL was 0.25 µm. © 2011 Optical Society of America

  15. Forehead and scalp sensation after brow-lift: a comparison between open and endoscopic techniques.

    Science.gov (United States)

    Guillot, Jason M; Rousso, Daniel E; Replogle, William

    2011-01-01

    To compare postoperative forehead and scalp sensation for the "open" brow-lift (OBL) (coronal and trichophytic) with that of the endoscopic brow-lift (EBL). A controlled outcome evaluation study was designed to objectively (mechanoceptive and thermoceptive) and subjectively (visual analog scale) test forehead and scalp sensation in a group of patients having undergone or scheduled to undergo either OBL or EBL in a single, private facial plastic surgery clinic. Prospectively enrolled participants were tested at defined intervals (A, preoperation; B,1-2 weeks after; C, 4-6 weeks after; D, 12-14 weeks after; and E, 24-26 weeks after). To provide extended follow-up data (≥6 months), patients returning for scheduled follow-up examination who had already undergone either OBL or EBL were subjected to the same test battery. For statistical analysis of the extended follow-up data, the participants were divided into 2 groups (F, 6-18 months; and G, >18 months). The null hypothesis was that there would be no measurable difference between the OBL and the EBL groups related to postoperative forehead and scalp sensation. Twenty-one individuals (EBL, n = 11; OBL, n = 10) were enrolled prospectively. All showed normal objective and subjective values preoperatively. While both groups objectively and subjectively demonstrated decreased sensation over follow-up, the OBL group showed statistically significant decrement in objective scalp sensitivity at times B, C, and D vs the EBL group. Subjectively, the OBL group felt less sensitive than the EBL group at times C and D. Those relationships disappeared at time E. Fifty-eight individuals were retrospectively enrolled. At time F (EBL, n = 16; OBL, n = 10), an objective and subjective difference was again observed with the OBL group demonstrating less scalp sensitivity vs the EBL group. At time G (EBL, n = 20; OBL, n = 12), this difference was no longer observed. We reject the null hypothesis and state that there is a measurable

  16. British Exit from the EU: Legal and Political Implications

    DEFF Research Database (Denmark)

    2016-01-01

    to the three editors of Graham Butler, Mads Dagnis Jensen, and Holly Snaith, the Debate Section includes contributions from Paul James Cardwell, Adam Łazowski, Daniela Annette Kroll, Dirk Leuffen, and Tim Oliver, that each delivers sharp compact contributions on different perspectives of ‘Brexit’, and wider......://dx.doi.org/10.1080/13501763.2016.1174529 4. When politics prevails: the political economy of a Brexit Mads Dagnis Jensen and Holly Snaith Journal of European Public Policy, 2016, Volume 23, Issue 9, pp. 1302-1310. http://dx.doi.org/10.1080/13501763.2016.1174531 5. Ties that bind, can also strangle: the Brexit...... threat and the hardships of reforming the EU Daniela Annette Kroll and Dirk Leuffen Journal of European Public Policy, 2016, Volume 23, Issue 9, pp. 1311-1320. http://dx.doi.org/10.1080/13501763.2016.1174532 6. European and international views of Brexit Tim Oliver Journal of European Public Policy, 2016...

  17. Morooka当选ICS新主席

    Institute of Scientific and Technical Information of China (English)

    张向辉(编译)

    2012-01-01

    5月25日,来自日本的Masamichi Morooka全票当选国际航运协会(ICS)主席,塞浦路斯的DirkFry.德国的FrankLeonhardt、挪威的TrygveSeglem以及菲律宾的GerardoBorromeo当选为ICS副主席。Morooka将负责联络包括IMO及ILO等在内的监管机构。

  18. Heterogenität der Finanzökonomie. Zur Sexualität in Spielfilmen über die Börse

    OpenAIRE

    Verdicchio, Dirk

    2012-01-01

    In this article, Dirk Verdicchio addresses the display of sexuality in cinematic movies on finance. He argues that the display of sexuality can be seen as a representation of the financial economy and asks how finance is perceived when it is envisioned by means of sexuality. Referring to George Bataille’s concepts of economy, heterogeneity, and erotics he argues that the display of sexuality in these films endangers conventional, bourgeois ideals and values – in Bataille’s terms: the financia...

  19. AfricaArray seismological studies of the structure and evolution of the African continent

    CSIR Research Space (South Africa)

    Durrheim, RJ

    2013-10-01

    Full Text Available the contributions of Steven Grand (University of Texas, USA), Jordi Julià (Federal University of Rio Grande do Norte, Brazil), Paul Dirks (James Cook University, Australia), Trond Ryberg (GFZ, Germany), Roger Gibson, Kim Hein and Zet Gumede (Wits University...), Nick King (Gold Fields), and Damien Delvaux (Royal Museum for Africa, Belgium). We also acknowledge support from the National Science Foundation, IRIS and UNAVCO (USA); the National Research Foundation and the Council for Geoscience (South Africa...

  20. Kas koostöö on vajadus või kohustus?

    Index Scriptorium Estoniae

    2008-01-01

    15. nov. 2007 toimus Tallinnas turismi aastakonverents "Kas koostöö on vajadus või kohustus?". Ülevaade Maailma Turismiorganisatsiooni riski- ja kriisijuhtimise osakonna juhataja Dirk Glaesseri, Footprint Traveli juhi Jason Barry, MTÜ Maaturism juhatuse esimehe Varri Väli, Kaleva Travel Eesti tegevdirektori Merike Halliku, Riigikogu liikme Urmas Klaase, Eesti Kaubandus-Tööstuskoja teenuste direktori Merike Kompus van der Hoeveni ettekannetest

  1. Proceedings of the Frontiers of Retrovirology Conference 2016

    OpenAIRE

    Zurnic, Irena; Hütter, Sylvia; Lehmann, Ute; Stanke, Nicole; Reh, Juliane; Kern, Tobias; Lindel, Fabian; Gerresheim, Gesche; Hamann, Martin; Müllers, Erik; Lesbats, Paul; Cherepanov, Peter; Serrao, Erik; Engelman, Alan; Lindemann, Dirk

    2016-01-01

    Table of contents Oral presentations Session 1: Entry & uncoating O1 Host cell polo-like kinases (PLKs) promote early prototype foamy virus (PFV) replication Irena Zurnic, Sylvia Hütter, Ute Lehmann, Nicole Stanke, Juliane Reh, Tobias Kern, Fabian Lindel, Gesche Gerresheim, Martin Hamann, Erik Müllers, Paul Lesbats, Peter Cherepanov, Erik Serrao, Alan Engelman, Dirk Lindemann O2 A novel entry/uncoating assay reveals the presence of at least two species of viral capsids during synchronized HIV...

  2. Use of frameless intrauterine devices and systems in young nulliparous and adolescent women: results of a multicenter study

    OpenAIRE

    Wildemeersch D; Jandi S; Pett A; Nolte K; Hasskamp T; Vrijens M

    2014-01-01

    Dirk Wildemeersch,1 Sohela Jandi,2 Ansgar Pett,2 Kilian Nolte,3 Thomas Hasskamp,4 Marc Vrijens5 1Gynecological Outpatient Clinic and IUD Training Center, Ghent, Belgium; 2Gynecological Outpatient Clinic, Berlin, 3Gynecological Outpatient Clinic, Uetze, 4GynMünster, Münster, Germany; 5Gynecological Outpatient Clinic, Ghent, Belgium Background: The purpose of this study was to provide additional data on the experience with frameless copper and levonorgestrel (LNG) intrauterin...

  3. Role of uterine forces in intrauterine device embedment, perforation, and expulsion

    OpenAIRE

    Goldstuck ND; Wildemeersch D

    2014-01-01

    Norman D Goldstuck,1 Dirk Wildemeersch2 1Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Western Cape, South Africa; 2Gynecological Outpatient Clinic and IUD Training Center, Ghent, Belgium Background: The purpose of this study was to examine factors that could help reduce primary perforation during insertion of a framed intrauterine device (IUD) and to determine factors that contribute in generating enough ut...

  4. Study of Software Tools to Support Systems Engineering Management

    Science.gov (United States)

    2015-06-01

    and DISA have established a Partnership Portfolio allowing for COSTCO pricing” (Smith 2011, 4). This should help overcome two significant challenges...mark-up  enterprise- class file synchronization  forms and data management  data hierarchies. Task management, dashboards, and workspaces will...to Completion.” Accessed January 22, 2015 http://www.threesl.com/pages/Cradle/ English /Content/Products/workbench.php. Bajaj, Manas, Dirk Zwemer

  5. Comparative study: The effects of solvent on the morphology, optical and structural features of regioregular poly(3-hexylthiophene):fullerene thin films

    CSIR Research Space (South Africa)

    Motaung, DE

    2010-01-01

    Full Text Available : The effects of solvent on the morphology, optical and structural features of regioregular poly(3-hexylthiophene): fullerene thin films David E. Motaung1, 2, Gerald F. Malgas1,*, Christopher J. Arendse2, and Dirk Knoesen2 1National Centre for Nano... solar cells, morphology * Corresponding Author: Dr. Gerald Malgas, Tel: (+27) 012 841 3972, Fax: (+27) 012 841 2229, Email: gmalgas@csir.co.za 2 1. INTRODUCTION In the last decade, solution...

  6. Factors of Religious Violence and a Path to Peace: A Study of the 16th Century Anabaptists

    Science.gov (United States)

    2015-06-01

    Stayer, Anabaptists and the Sword, 287. 138 Ibid., 294. 33 Following Batenburg’s execution, the group was led by Cornelis Appelman, who continued to...destruction.143 They were the groups Batenburg saw as his largest competitors . David Joris, Obbe, and Dirk Philips were all at the top of the list, all of...1539213 Name Group Affiliation Position on Violence Status Appleman, Cornelis Batenburger V Alive, viewed as a bandit Hofmann, Melchior

  7. Kas koostöö on vajadus või kohustus?

    Index Scriptorium Estoniae

    2008-01-01

    15. nov. 2007 toimus Tallinnas turismi aastakonverents "Kas koostöö on vajadus või kohustus?". Ülevaade Maailma Turismiorganisatsiooni riski- ja kriisijuhtimise osakonna juhataja Dirk Glaesseri, Footprint Traveli juhi Jason Barry, MTÜ Maaturism juhatuse esimehe Varri Väli, Kaleva Travel Eesti tegevdirektori Merike Halliku, Riigikogu liikme Urmas Klaase, Eesti Kaubandus-Tööstuskoja teenuste direktori Merike Kompus van der Hoeveni ettekannetest

  8. Bridging the gap between biodiversity data and policy reporting needs: An essential biodiversity variables perspective

    CSIR Research Space (South Africa)

    Geijzendorffer, IR

    2016-01-01

    Full Text Available Institute and Natural History Museum Frankfurt, Department of River Ecology and Conservation, Martin, Corinne; UNEP-WCMC, Mihoub, Jean-Baptiste; Department of Conservation Biology, Helmholtz Centre for Environmental Research – UFZ, Secades, Cristina...; UNEP-WCMC, Schmeller, Dirk; Helmholtz Centre for Environmental Research – UFZ, Department of Conservation Biology Stoll, Stefan; Senckenberg Research Institute and Natural History Museum Frankfurt, Department of River Ecology and Conservation...

  9. The opposing perspectives on creating shared value : Living the Ambiguity of Creating Shared Value

    OpenAIRE

    Dyllick, Thomas

    2014-01-01

    This is a contribution to a debate between many scholars on the topic of Michael Porter and Mark Kramer's Creating Shared Value concept (Harveard Business Review, January/February 2011, 62-77, and the critique presented by Andrew Crane, Guido Palazzo, Laura Spence & Dirk Matten in California Management Review, Vol. 56, No. 2 (Winter 2014), 130-153 under the title of "Contesting the Value of "Creating Shared Value".

  10. European Energy Security and Nord Stream: A Case Study of the Nord Stream Pipeline, Its Opportunities and Risks for Europe, and Its Impact on European Energy Security

    Science.gov (United States)

    2011-06-01

    System of Gas Supplies xiii ACKNOWLEDGMENTS I would like to thank my co-advisors, Professor Robert Looney and COL (G.S.) (GAF) Dirk Rogalski...74 European Commission, Green Paper. 75 European Union, A secure Europe in a better world: European Security Strategy. 76 European Union, Europa ...online, 13 September 2010, http://www.zeit.de/wirtschaft/2010-09/wachstum-deutschland- europa (accessed 3 February 2011). 277 Deutscher Bundestag, Basic

  11. Mechanisms of Metal Release From Contaminated Coastal Sediments

    Science.gov (United States)

    2005-09-01

    years so enjoyable - Mea, Heidi, Jeff, Kristy, Oscar, Charlie, Jessica, Carlos, Adam, Jim, Dirk, 5 Heather, Michael, Sarah , Patty, Boa, Susan, Gary...critical shear stress of 0.08 Nm- 2 in Buzzards Bay. In Baltimore Harbor Maa et al. [1998] 179 deployed the VIMS Sea Carousel at four sites and reported a...Bruland, J. Burton, and E. Goldberg, NATO, 1983. Maa , J.-Y., L. Sanford, and J. Halka, Sediment resuspension characteristics in Baltimore Harbor

  12. Ultraviolet Light Emitting Diode Optical Power Characterization

    Science.gov (United States)

    2014-03-01

    14 Mar 14___ Dirk P. Yamamoto , Lt Col, USAF, Ph.D., BSC (Member) Date //Signed...et al (2009) explored the inactivation of Escherichia coli using continuous UV output and a pulsed 9.1 percent duty cycle output using the same peak...with the available equipment. The oscilloscope could be used to show the trace and measure a voltage drop across a known resistance in line with the

  13. Diagonally Implicit Runge-Kutta Methods for Ordinary Differential Equations. A Review

    Science.gov (United States)

    Kennedy, Christopher A.; Carpenter, Mark H.

    2016-01-01

    A review of diagonally implicit Runge-Kutta (DIRK) methods applied to rst-order ordinary di erential equations (ODEs) is undertaken. The goal of this review is to summarize the characteristics, assess the potential, and then design several nearly optimal, general purpose, DIRK-type methods. Over 20 important aspects of DIRKtype methods are reviewed. A design study is then conducted on DIRK-type methods having from two to seven implicit stages. From this, 15 schemes are selected for general purpose application. Testing of the 15 chosen methods is done on three singular perturbation problems. Based on the review of method characteristics, these methods focus on having a stage order of two, sti accuracy, L-stability, high quality embedded and dense-output methods, small magnitudes of the algebraic stability matrix eigenvalues, small values of aii, and small or vanishing values of the internal stability function for large eigenvalues of the Jacobian. Among the 15 new methods, ESDIRK4(3)6L[2]SA is recommended as a good default method for solving sti problems at moderate error tolerances.

  14. Small duodenal carcinoids: a case series comparing endoscopic resection and autoamputation with band ligation.

    Science.gov (United States)

    Scherer, John R; Holinga, Julie; Sanders, Michael; Chennat, Jennifer; Khalid, Asif; Fasanella, Kenneth; Singhi, Aatur D; McGrath, Kevin

    2015-04-01

    We sought to compare the efficacy and safety of endoscopic ultrasound-guided endoscopic resection (ER) and endoscopic band ligation (EBL) for autoamputation of small duodenal carcinoids. The ideal management of small duodenal carcinoid tumors remains unclear. A retrospective review of duodenal carcinoids over a 10-year period (2002 to 2012) was performed at our tertiary-care teaching hospital. All patients with duodenal carcinoids ≤10 mm in size treated with either ER or EBL were included. The main outcome measurements were the efficacy and safety of endotherapy. A total of 37 patients with 39 subcentimeter duodenal carcinoids were identified. In the EBL group, the mean (SD) tumor size was 6.7±2.1 mm compared with 6.7±1.7 mm in the ER group (P=0.943). The mean Ki-67 index was ≤2% in specimens available for histologic analysis in both groups (16/23 EBL and 15/16 ER). The positive deep margin rate in the ER group was 68.8%. Residual carcinoid tumor cells were detected on follow-up biopsies in 1 patient after EBL, and 2 patients after ER. All underwent subsequent successful endotherapy. No adverse events occurred in the EBL group compared with an 18.8% adverse event rate in the ER group (P=0.066). Endoscopic ultrasound-guided EBL is a safe, effective method for removal of small superficial duodenal carcinoids and seems to be a lower risk alternative to conventional ER with cautery.

  15. Identification of a novel variant of LMP-1 of EBV in patients with endemic Burkitt lymphoma in western Kenya.

    Science.gov (United States)

    Wohlford, Eric M; Asito, Amolo S; Chelimo, Kiprotich; Sumba, Peter O; Baresel, Paul C; Oot, Rebecca A; Moormann, Ann M; Rochford, Rosemary

    2013-09-09

    Epstein Barr virus (EBV) is a gammaherpesvirus that is associated with nasopharyngeal carcinoma (NPC) and endemic Burkitt lymphoma (eBL). EBV carries several latent genes that contribute to oncogenesis including the latent membrane protein 1 (LMP-1), a known oncogene and constitutively active CD40 homolog. Variation in the C terminal region of LMP-1 has been linked to NPC pathogenesis, but little is known regarding LMP-1 variation and eBL. In the present study, peripheral blood samples were obtained from 38 eBL patients and 22 healthy controls in western Kenya, where the disease is endemic. The LMP-1 C-terminal region from these samples was sequenced and analyzed. The frequency of a 30 base pair deletion of LMP-1 previously linked to NPC was not associated with eBL compared to healthy controls. However a novel LMP-1 variant was identified, called K for Kenya and for the G318K mutation that characterizes it. The K variant LMP-1 was found in 40.5% of eBL sequences and 25.0% of healthy controls. All K variant sequences contained mutations in both of the previously described minimal T cell epitopes in the C terminal end of LMP-1. These mutations occurred in the anchor residue at the C-terminal binding groove of both epitopes, a pocket necessary for MHC loading. Overall, our results suggest that there is a novel K variant of LMP-1 in Kenya that may be associated with eBL. Further studies are necessary to determine the functional implications of the LMP-1 variant on early events in eBL genesis.

  16. 24-Epibrassinolide ameliorates salt stress effects in the symbiosis Medicago truncatula-Sinorhizobium meliloti and regulates the nodulation in cross-talk with polyamines.

    Science.gov (United States)

    López-Gómez, Miguel; Hidalgo-Castellanos, Javier; Lluch, Carmen; Herrera-Cervera, José A

    2016-11-01

    Brassinosteroids (BRs) are steroid plant hormones that have been shown to be involved in the response to salt stress in cross-talk with other plant growth regulators such as polyamines (PAs). In addition, BRs are involved in the regulation of the nodulation in the rhizobium-legume symbiosis through the alteration of the PAs content in leaves. In this work, we have studied the effect of exogenous 24-epibrassinolide (EBL) in the response to salinity of nitrogen fixation in the symbiosis Medicago truncatula-Sinorhizobium meliloti. Foliar spraying of EBL restored the growth of plants subjected to salt stress and provoked an increment of the nitrogenase activity. In general, PAs levels in leaves and nodules decreased by the salt and EBL treatments, however, the co-treatment with NaCl and EBL augmented the foliar spermine (Spm) concentration. This increment of the Spm levels was followed by a reduction of the membrane oxidative damage and a diminution of the proline accumulation. The effect of BRs on the symbiotic interaction was evaluated by the addition of 0.01, 0.1 and 0.5 μM EBL to the growing solution, which provoked a reduction of the nodule number and an increment of the PAs levels in shoot. In conclusion, foliar treatment with EBL had a protective effect against salt stress in the M. truncatula-S. meliloti symbiosis mediated by an increment of the Spm levels. Treatment of roots with EBL incremented PAs levels in shoot and reduced the nodule number which suggests a cross-talk between PAs and BRs in the nodule suppression and the protection against salt stress. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  17. High Levels of IL-10 and CD4+CD25hi+ Treg Cells in Endemic Burkitt's Lymphoma Patients.

    Science.gov (United States)

    Futagbi, Godfred; Gyan, Ben; Nunoo, Harriet; Tetteh, John K A; Welbeck, Jennifer E; Renner, Lorna Awo; Ofori, Michael; Dodoo, Daniel; Edoh, Dominic A; Akanmori, Bartholomew D

    2015-08-04

    The interplay between Epstein-Barr virus infection, malaria, and endemic Burkitt's Lymphoma is not well understood. Reports show diminished EBV-specific Th1 responses in children living in malaria endemic areas and deficiency of EBNA1-specific IFN-γ T cell responses in children with endemic Burkitt's Lymphoma (eBL). This study, therefore, examined some factors involved in the loss of EBNA-1-specific T cell responses in eBL. T-cell subset frequencies, activation, and IFN-γ- or IL-4-specific responses were analyzed by flow-cytometry. Plasma cytokine levels were measured by ELISA. CD4+ and CD8+ cells in age- and sex-matched healthy controls (n = 3) expressed more IFN-γ in response to all immunostimulants than in pediatric endemic BL (eBL) patients (n = 4). In healthy controls, IFN-γ expression was higher than IL-4 expression, whereas in eBL patients the expression of IL-4 by CD4+ cells to EBNA-1 was slightly higher than IFN-γ. Moreover, the blood levels of TNF-α was significantly lower (p = 0.004) while IL-10 was significantly higher (p = 0.038), in eBL patients (n = 21) compared to controls (n = 16). Additionally, the frequency of CD4+CD25hi+ T cells was higher in both age-matched acute uncomplicated malaria (n = 26) and eBL (n = 14) patients compared to healthy controls (n = 19; p = 0.000 and p = 0.027, respectively). The data suggest that reduced Th1 response in eBL might be due to increased levels of IL-10 and T reg cells.

  18. Editorial: Neue Medien und individuelle Leistungsdarstellung: Möglichkeiten und Grenzen von ePortfolios und eAssessments

    Directory of Open Access Journals (Sweden)

    Claudia de Witt

    2010-03-01

    -Portfolios für die Kompetenzerfassung von Lernenden an Schulen und Hochschulen heraus. Aufbauend auf Thomas Häckers dreidimensionalem heuristischen Modell zur Charakterisierung von Portfolios erarbeiten die AutorInnen ein Analyseraster, das Lehrenden, die (E-Portfolios in ihren Veranstaltungen nutzen wollen, als Instrument dienen kann, deren Einführungsprozess zu unterstützen und als Lernprozess zu gestalten. Das veränderte Mediennutzungsverhalten Jugendlicher und junger Erwachsener im Web 2.0 steht bei Michael J. Eble im Fokus. Die zunehmende Nutzung von Social Networks wie Facebook zur individuellen Selbstdarstellung kann nach Eble in Kombination von E-Portfolios und dem identitätsbasierenden Ansatz der Markenbildung für die Abbildung eigener Lern- und Leistungsentwicklung in Lehr- und Lernkontexten nutzbar gemacht werden. Unter drei zentralen Fragestellungen zur Auseinandersetzung mit der eigenen Person und Identität, zum Bezug zwischen persönlicher Markenbildung und formellen Lehr-Lern-Kontexten und zur Adoption und Akzeptanz von E-Portfolios untersucht Eble Chancen und Grenzen von E-Portfolios im Zeitalter des Social Networking. Dirk Jahn, Bernhard Trager und Karl Wilbers zeigen am Beispiel einer beruflichen Weiterbildung für Berufsbildungspersonal aus der Aus- und Weiterbildung im Einzelhandel die Möglichkeiten des Portfolioeinsatzes zur Qualifizierung dieser pädagogischen Professionals in restriktiven Settings. Als Grundlage für die Gestaltung von E-Portfolios dienen den Autoren in diesem Zusammenhang die Referenztheorien des Konzeptwandels, der Selbstreflexion und des kritischen Denkens. Darauf basierend werden die Phasen der E-Portfolioarbeit beispielhaft beschrieben, wobei vor allem die Einstiegsphase und der dissonanzgetriebene E-Portfolio-Prozess als bedeutend für das Gelingen der portfoliogestützten Qualifizierung der pädagogischen Professionals markiert werden. Selbstgesteuertes, reflexives Lernen gilt heute als Grundlage für erfolgreiches

  19. A RETROSPECTIVE STUDY OF THE IMPACT OF MEAN ARTERIAL PRESSURE ON ESTIMATED BLOOD LOSS DURING ENDOSCOPIC SINUS SURGERY

    Directory of Open Access Journals (Sweden)

    George W Williams

    2014-10-01

    Full Text Available The current practice of lowering mean arterial pressure (MAP during endoscopic sinus surgery (ESS is common, but unproven with regard to peer reviewed literature. The controlled hypotension induced is aimed for improved surgical field and lower the blood loss. Lower mean arterial pressures especially for prolonged surgeries may result in end organ hypoperfusion. The authors reviewed all patients who underwent outpatient endoscopic sinus surgery for the diagnosis of chronic sinusitis from January 1, 2012 to December 31, 2012 at Memorial Hermann Hospital – Texas Medical Centre. We individually reviewed case sheets of every patient and documented blood loss as recorded on the anaesthesia record or in the surgical procedure note, among other variables. A total of 326 patients were included in this study. The median estimated blood loss (EBL was found to be 50 ml. The multivariate regression analysis between these three groups showed that EBL was higher in MAP 75 group. The average of EBL in MAP75 group and the average of EBL in MAP 65-70 group is 42% higher than that in MAP>75 group when other variables were fixed. Hence we found the trend toward higher blood loss with lower MAP. The authors conclude that lower MAP does not result in lower EBL in endoscopic sinus surgery. Furthermore, increases in BMI and crystalloid administered during an aesthetic management of these cases correlates with increased estimate blood loss.

  20. Optical and electronic proprieties of thin films based on (Z-5-(4-chlorobenzylidene-3-(2-ethoxyphenyl-2 thioxothiazolidin-4-one, (CBBTZ and possible application as exciton-blocking layer in heterojunction organic solar cells

    Directory of Open Access Journals (Sweden)

    Morsli M.

    2012-06-01

    Full Text Available In this work, organic thin film solar cells with structures based on CuPc/C60 bulk heterojunctions, have been fabricated and characterized. The effect of introducing an exciton blocking layer (EBL between the active layer and the metal layer in the solar cell was investigated. For that (Z-5-(4-chlorobenzylidene-3-(2-ethoxyphenyl-2-thioxothiazolidin-4-one, that we called (CBBTZ has been synthesized, characterized and probed as EBL. It was shown that optimized structures containing EBLs resulted in an improvement in solar cell conversion efficiencies. The energy levels corresponding to the highest occupied molecular orbital (HOMO and the lowest unoccupied molecular orbital (LUMO of the CBBTZ have been determined from the first oxidation and reduction potential respectively, using cyclic voltametric (CV measurements. From CV curves, CBBTZ in dichloromethane showed a one electron reversible reduction and oxidation waves. The values of its HOMO and LUMO have been estimated to be 6.42 eV and 3.42 eV respectively. Such values show that CBBTZ could be probed as EBL in organic solar cells based on the ED/EA couple copper phthalocyanine(CuPc/fullerene (C60. The photovoltaic solar cells have been obtained by sequential deposition under vacuum of the different films where their thicknesses were measured in situ by a quartz monitor. When obtained, the averaged efficiency of the cells using the CBBTZ is higher than that achieved without EBL layer.

  1. Child health nurses' perceptions of enquiry-based learning.

    Science.gov (United States)

    Glasper, E A

    Since the publication of Fitness for Practice (UKCC, 1999), most preregistration nursing curriculae embrace the principles of enquiry-based learning (EBL) as a method of educating students. EBL uses genuine real-life client scenarios which provide the students with an opportunity to explore a range of issues directly pertaining to client care in a variety of contemporary nursing settings (Long et al, 1999). This evaluative study of one group (n=12) of child branch students conducted during the last EBL session of the course reflects the students' experiences of this method of teaching over a 3-year period. Nominal group technique (Delbecq and Van de Ven, 1971) was utilized to give a quantitative dimension to the reporting and recording of individual student reflections of EBL. The results demonstrate overall satisfaction with this method of student learning. A number of concerns raised by students reflect some of the pitfalls associated with EBL and these have important ramifications for nurse educators and clinical placement mentors. However, the small size limitations of this study do not allow for generalizability.

  2. The extragalactic background light, the Hubble constant, and anomalies: conclusions from 20 years of TeV gamma-ray observations

    CERN Document Server

    Biteau, Jonathan

    2015-01-01

    Ground-based observatories have been collecting 0.2-20 TeV gamma rays from blazars for about twenty years. These gamma rays can experience absorption along the line of sight due to interactions with the extragalactic background light (EBL). In this paper, we investigate the most extensive set of TeV spectra from blazars collected so far, twice as large as any other studied. We first show that the gamma-ray optical depth can be reduced to the convolution product of an EBL kernel with the EBL intensity. We extract the EBL intensity from the gamma-ray spectra, show that it is preferred at 11 sigma to a null intensity, and unveil the broad-band spectrum of the EBL from mid-UV to far IR. Our measurement shows that the total radiative content of the universe between 0.1 and 1000 microns represents 6.5+/-1.2% of the brightness of the CMB. This is slightly above the accumulated emission of stars and galaxies and constrains the unresolved sources that could have reionized the universe. We also propose a data-driven me...

  3. Aberration-Corrected Electron Beam Lithography at the One Nanometer Length Scale.

    Science.gov (United States)

    Manfrinato, Vitor R; Stein, Aaron; Zhang, Lihua; Nam, Chang-Yong; Yager, Kevin G; Stach, Eric A; Black, Charles T

    2017-08-09

    Patterning materials efficiently at the smallest length scales is a longstanding challenge in nanotechnology. Electron-beam lithography (EBL) is the primary method for patterning arbitrary features, but EBL has not reliably provided sub-4 nm patterns. The few competing techniques that have achieved this resolution are orders of magnitude slower than EBL. In this work, we employed an aberration-corrected scanning transmission electron microscope for lithography to achieve unprecedented resolution. Here we show aberration-corrected EBL at the one nanometer length scale using poly(methyl methacrylate) (PMMA) and have produced both the smallest isolated feature in any conventional resist (1.7 ± 0.5 nm) and the highest density patterns in PMMA (10.7 nm pitch for negative-tone and 17.5 nm pitch for positive-tone PMMA). We also demonstrate pattern transfer from the resist to semiconductor and metallic materials at the sub-5 nm scale. These results indicate that polymer-based nanofabrication can achieve feature sizes comparable to the Kuhn length of PMMA and ten times smaller than its radius of gyration. Use of aberration-corrected EBL will increase the resolution, speed, and complexity in nanomaterial fabrication.

  4. Dynamic measurements and simulations of airborne picolitre-droplet coalescence in holographic optical tweezers.

    Science.gov (United States)

    Bzdek, Bryan R; Collard, Liam; Sprittles, James E; Hudson, Andrew J; Reid, Jonathan P

    2016-08-07

    We report studies of the coalescence of pairs of picolitre aerosol droplets manipulated with holographic optical tweezers, probing the shape relaxation dynamics following coalescence by simultaneously monitoring the intensity of elastic backscattered light (EBL) from the trapping laser beam (time resolution on the order of 100 ns) while recording high frame rate camera images (time resolution optical traps; assign the origin of key features in the time-dependent EBL intensity; and validate the use of the EBL alone to precisely determine droplet surface tension and viscosity. For low viscosity droplets, two sequential processes are evident: binary coalescence first results from the overlap of the optical traps on the time scale of microseconds followed by the recapture of the composite droplet in an optical trap on the time scale of milliseconds. As droplet viscosity increases, the relaxation in droplet shape eventually occurs on the same time scale as recapture, resulting in a convoluted evolution of the EBL intensity that inhibits quantitative determination of the relaxation time scale. Droplet coalescence was simulated using a computational framework to validate both experimental approaches. The results indicate that time-dependent monitoring of droplet shape from the EBL intensity allows for robust determination of properties such as surface tension and viscosity. Finally, the potential of high frame rate imaging to examine the coalescence of dissimilar viscosity droplets is discussed.

  5. Efficacy of β-adrenergic blocker plus 5-isosorbide mononitrate and endoscopic band ligation for prophylaxis of esophageal variceal rebleeding: A meta-analysis

    Institute of Scientific and Technical Information of China (English)

    Shi-Hua Ding; Jun Liu; Jian-Ping Wang

    2009-01-01

    AIM: To systematically assess the efficacy and safety of β-adrenergic blocker plus 5-isosorbide mononitrate (BB + ISMN) and endoscopic band ligation (EBL) on prophylaxis of esophageal variceal rebleeding. METHODS: Randomized controlled trials (RCTs) comparing the efficacy and safety of BB + ISMN and EBL on prophylaxis of esophageal variceal rebleeding were gathered from Medline, Embase, Cochrane Controlled Trial Registry and China Biological Medicine database between January 1980 and August 2007. Data from five trials were extracted and pooled. The analyses of the available data using the Revman 4.2 software were based on the intention-to-treat principle. RESULTS: Four RCTs met the inclusion criteria. In comparison with BB + ISMN with EBL in prophylaxis of esophageal variceal rebleeding, there was no significant difference in the rate of rebleeding [relative risk (RR), 0.79; 95% CI: 0.62-1.00; P = 0.05], bleedingrelated mortality (RR, 0.76; 95% CI: 0.31-1.42; P = 0.40), overall mortality (RR, 0.81; 95% CI: 0.61-1.08; P = 0.15) and complications (RR, 1.26; 95% CI: 0.93-1.70; P = 0.13). CONCLUSION:In the prevention of esophageal variceal rebleeding, BB + ISMN are as effective as EBL. There are few complications with the two treatment modalities. Both BB + ISMN and EBL would be considered as the first-line therapy in the prevention of esophageal variceal rebleeding.

  6. "Leading blob" model in a stochastic acceleration scenario: the case of the 2009 flare of Mkn~501

    CERN Document Server

    Lefa, E; Rieger, F M

    2011-01-01

    Evidence for very hard, intrinsic $\\gamma$-ray source spectra, as inferred after correction for absorption in the extragalactic background light (EBL), has interesting implications for the acceleration and radiation mechanisms acting in blazars. A key issue so far has been the dependance of the hardness of the $\\gamma$-ray spectrum on different existing EBL models. The recent {\\it Fermi} observations of Mkn~501 now provide additional evidence for the presence of hard intrinsic $\\gamma$-ray spectra independent of EBL uncertainties. Relativistic Maxwellian-type electron energy distributions that are formed in stochastic acceleration scenarios offer a plausible interpretation for such hard source spectra. Here we show that the combined emission from different components with Maxwellian-type distributions could in principle also account for more softer and broader, power law-like emission spectra. We introduce a "leading blob" scenario, applicable to active flaring episodes, when one (or few) of these components ...

  7. Formalizing dependency directed backtracking and explanation based learning in refinement search

    Energy Technology Data Exchange (ETDEWEB)

    Kambhampati, S. [Arizona State Univ., Tempe, AZ (United States)

    1996-12-31

    The ideas of dependency directed backtracking (DDB) and explanation based learning (EBL) have developed independently in constraint satisfaction, planning and problem solving communities. In this paper, I formalize and unify these ideas under the task-independent framework of refinement search, which can model the search strategies used in both planning and constraint satisfaction. I show that both DDB and EBL depend upon the common theory of explaining search failures, and regressing them to higher levels of the search tree. The relevant issues of importance include (a) how the failures are explained and (b) how many failure explanations are remembered. This task-independent understanding of DDB and EBL helps support cross-fertilization of ideas among Constraint Satisfaction, Planning and Explanation-Based Learning communities.

  8. A low density of the Extragalactic Background Light revealed by the H.E.S.S. spectra of the BLLac objects 1ES 1101-232 and H 2356-309

    CERN Document Server

    Costamante, L

    2006-01-01

    The unexpectedly hard spectra measured by HESS for the BLLacs 1ES 1101-232 and H 2356-309 has allowed an upper limit on the Extragalactic Background Light (EBL) to be derived in the optical/near-infrared range, which is very close to the lower limit given by the resolved galaxy counts. This result seems to exclude a large contribution to the EBL from other sources (e.g. Population III stars) and indicates that the intergalactic space is more transparent to gamma-rays than previously thought. A brief discussion of EBL absorption effects on blazar spectra and further observational tests to check this conclusion are presented, including the selection of new candidates for observations with Cherenkov telescopes.

  9. Using low-contrast negative-tone PMMA at cryogenic temperatures for 3D electron beam lithography.

    Science.gov (United States)

    Schnauber, Peter; Schmidt, Ronny; Kaganskiy, Arsenty; Heuser, Tobias; Gschrey, Manuel; Rodt, Sven; Reitzenstein, Stephan

    2016-05-13

    We report on a 3D electron beam lithography (EBL) technique using polymethyl methacrylate (PMMA) in the negative-tone regime as a resist. First, we briefly demonstrate 3D EBL at room temperature. Then we concentrate on cryogenic temperatures where PMMA exhibits a low contrast, which allows for straightforward patterning of 3D nano- and microstructures. However, conventional EBL patterning at cryogenic temperatures is found to cause severe damage to the microstructures. Through an extensive study of lithography parameters, exposure techniques, and processing steps we deduce a hypothesis for the cryogenic PMMA's structural evolution under electron beam irradiation that explains the damage. In accordance with this hypothesis, a two step lithography technique involving a wide-area pre-exposure dose slightly smaller than the onset dose is applied. It enables us to demonstrate a >95% process yield for the low-temperature fabrication of 3D microstructures.

  10. The Style of Business Letters

    Institute of Scientific and Technical Information of China (English)

    Li Kai

    2008-01-01

    This study explores the application of Systemic Functional Granunar (SFG) to the analysis of English Business Letters (EBL). With China's opening up to the outside, especially its entrance into WTO, international business is becoming more and more popular. Most of the transactions in international business are discussed in detail through airmail letters, telegrams, telexes, faxes or E-mails.As a world language, English is used widely in the negotiation of international businesses. Writing a piece of effective English Business Letter is of great importance. As a medium between the business partners, EBL affects the interaction and negotiation between them. This article is intended to seek the linguistic characteristics of business letters and prove that the theories of SFG can be used to analyze EBL discourse and they are actually effective.

  11. Involving mental health service users in nurse education through enquiry-based learning.

    Science.gov (United States)

    Rush, Brenda; Barker, Janet H

    2006-09-01

    Service user involvement and enquiry-based learning (EBL) are two modern approaches to nurse education, which previously have remained separate entities. This article describes an innovative project that brought together the two learning methods within the University of Nottingham. Mental health service users participated actively in the EBL process with student nurses to facilitate learning in the classroom before, during and after mental health placements. The process is described and an evaluation presented with examples of student responses showing how the experience inspired the students and contributed to the development of their understanding of mental health issues in both theory and practice. It is hoped that the article will encourage other health and social care professionals nationally and internationally to realise the potential of integrating service user involvement and EBL.

  12. Ocorrência da infecção causada pelos vírus da leucose bovina no Estado de São Paulo

    Directory of Open Access Journals (Sweden)

    Eduardo Harry Birgel

    1991-06-01

    Full Text Available Enzootic Bovine Leukosis (EBL has been known since the last century and nowadays it is considered cosmopolite. In Brazil, EBL has been described in many States. The objective of this paper is to divulge the results of the activities of EBL Diagnostic Laboratory at the Department of Medical Clinics of the Faculty of the Veterinary Medicine of the University of São Paulo between the years 1986and 1989. From 2708 samples of blood serum obtained from bovines raised in the State of São Paulo, 1162 samples showed a positive reaction by the agar-gel immune diffusion test (42.9%. It was verified the existence of reactor bovines in the 22 districts included in this study.

  13. Performance enhancement of AlGaN-based ultraviolet light-emitting diodes by inserting the last quantum well into electron blocking layer

    Science.gov (United States)

    Li, Fangzheng; Wang, Lianshan; Zhao, Guijuan; Meng, Yulin; Li, Huijie; Yang, Shaoyan; Wang, Zhanguo

    2017-10-01

    The characteristics of AlGaN-based ultraviolet light-emitting diodes (UV LEDs) with the last quantum well inserted into electron blocking layer(EBL) have been investigated numerically in this study. The simulation results indicate that the light-emitting EBL(LEEBL) can suppress electron leakage better than traditional EBL due to the superior electron confinement and hole injection of the quantum well in LEEBL. Besides, the LEEBL with a quantum well closer to active region can further improve the performance of the UV LED owning to better electron blocking and hole injection for the quantum wells in active region. As a result, the output power of the UV LED with the quantum well located in the middle of LEEBL increases by 17.83% and the utilization of LEEBL with a quantum well located closer to the active region can further enhance the output power by 54.11% compared with traditional UV LED.

  14. Enzootic bovine leukosis: report of eradication and surveillance measures in Italy over an 8-year period (2005-2012).

    Science.gov (United States)

    Maresca, C; Costarelli, S; Dettori, A; Felici, A; Iscaro, C; Feliziani, F

    2015-05-01

    Bovine leukaemia virus (BLV) is associated with enzootic bovine leukosis (EBL). BLV causes malignant lymphoma and lymphosarcoma; however, most BLV infections remain clinically silent in an aleukaemic state. EBL is a notifiable disease, and official control measures include screening or monitoring, precautions at borders, control of movement inside the country, and stamping out. The objective of this study was to evaluate EBL eradication and surveillance measures in Italy from 2005 to 2012. One-hundred twenty-three outbreaks were recorded (1 January 2006 to 31 December 2012) in the National Veterinary Information System (SIMAN) on 7 November 2013. Of these, 101 had occurred in southern Italy. An outbreak usually lasted for a few days, but sometimes lasted for weeks. Some areas were subjected to normal eradication measures, whereas others were subjected to additional eradication measures as a consequence of persisting EBL outbreaks. During the study period, we noted an overall annual decrease from 0.21% in 2005 to 0.08% in 2012 in the herd prevalence rate, from 0.06% in 2005 to 0.04% in 2012 in the herd incidence rate, and from 0.027% in 2005 to 0.015% in 2012 in the animal prevalence rate. Regions officially recognised as EBL-free areas were found to have their own surveillance plans. Differences in their surveillance plans include the type of sample (serum, milk, or both), age at which the animals must be tested (12 or 24 months), and test frequency of herds (annually or every 2, 3, 4, 5, or 6 years). The eradication programme for EBL is difficult to implement in some Italian areas because of several factors such as incomplete herd registry, geographical location and socio-economic conditions of the region.

  15. Differential expression analysis of boron transporters and some stress-related genes in response to 24-epibrassinolide and boron by semi-quantitative RT-PCR in Arabidopsis thaliana (L. Heynh

    Directory of Open Access Journals (Sweden)

    Surgun Yonca

    2016-01-01

    Full Text Available Plant steroidal hormones, brassinosteroids (BRs, promote plant developmental processes and enhance tolerance to several abiotic stresses including high boron (B stress. To examine the possible role of BR in high B-induced stress at the transcriptional level, we investigated the response of B transporter genes (BOR1-4, high B-induced genes (MATE, Hsp-like, BR-induced genes (Hsp70-4, Hsp90-1 and other stress-related genes (LTI/COR78, LEA4-5 upon exogenous treatments of 24-epibrassinolide (EBL on Arabidopsis thaliana (L. Heynh exposed to high concentrations of boric acid (BA using semi-quantitative RT-PCR. BA treatments led to down regulation of BOR1 and BOR3 genes in leaf and root tissues and higher concentration of EBL further decreased expression of these genes in roots. The expression of high B-induced genes was observed to be upregulated by 1 μM EBL treatment under high B stress in both tissues of the seedlings. The upregulation of BR-induced genes were clearly evident in root tissues co-treated with 1 μM EBL and BA as compared to BA alone. Higher concentration of EBL was found to be more effective in increasing expression of LTI/COR78 gene in root and LEA4-5 gene in shoot tissues. To our knowledge, this is the first report how exogenous application of EBL modulates high B stress responses at molecular level in model plant Arabidopsis thaliana.

  16. The extragalactic background light revisited and the cosmic photon-photon opacity

    Science.gov (United States)

    Franceschini, Alberto; Rodighiero, Giulia

    2017-07-01

    Context. In addition to its relevant astrophysical and cosmological significance, the extragalactic background light (EBL) is a fundamental source of opacity for cosmic high energy photons, as well as a limitation for the propagation of high-energy particles in the Universe. Aims: We review our previously published determinations of the EBL photon density in the Universe and its evolution with cosmic time, in the light of recent surveys of IR sources at long wavelengths. Methods: We exploit deep survey observations by the Herschel Space Observatory and the Spitzer telescope, matched to optical and near-IR photometric and spectroscopic data, to re-estimate number counts and luminosity functions longwards of a few microns, and the contribution of resolved sources to the EBL. Results: These new data indicate slightly lower photon densities in the mid- and far-infrared and sub-millimeter compared to previous determinations. This implies slightly lower cosmic opacity for photon-photon interactions. Conclusions: The new data do not modify previously published EBL modeling in the UV-optical and near-IR up to several microns, while reducing the photon density at longer wavelengths. This improved model of the EBL alleviates some tension that had emerged in the interpretation of the highest-energy TeV observations of local blazars, reducing the case for new physics beyond the standard model (like violations of the Lorenz Invariance, LIV, at the highest particle energies), or for exotic astrophysics, that had sometimes been called for to explain it. Applications of this improved EBL model on current data are considered, as well as perspectives for future instrumentation, the Cherenkov Telescope Array (CTA) in particular.

  17. Accuracy of postpartum haemorrhage data in the 2011 Victorian Perinatal Data Collection: Results of a validation study.

    Science.gov (United States)

    Flood, Margaret; Pollock, Wendy; McDonald, Susan J; Davey, Mary-Ann

    2017-08-31

    The postpartum haemorrhage (PPH) rate in Victoria in 2009 for women having their first birth, based on information reported to the Victorian Perinatal Data Collection (VPDC), was 23.6% (primiparas). Prior to 2009 PPH was collected via a tick box item on the perinatal form. Estimated blood loss (EBL) volume is now collected and it is from this item the PPH rate is calculated. Periodic assessment of data accuracy is essential to inform clinicians and others who rely on these data of their quality and limitations. This paper describes the results of a state-wide validation study of the accuracy of EBL volume and EBL-related data items reported to VPDC. PPH data from a random sample of 1% of births in Victoria in 2011 were extracted from source medical records and compared with information submitted to the VPDC. Accuracy was determined, together with sensitivity, specificity, positive predictive value and negative predictive value for dichotomous items. Accuracy of reporting for EBL ≥ 500 mL was 97.2% and for EBL ≥ 1500 mL was 99.7%. Sensitivity for EBL ≥ 500 mL was 89.0% (CI 83.1-93.0) and for EBL ≥ 1500 mL was 71.4% (CI 35.9-91.8). Blood product transfusion, peripartum hysterectomy and procedures to control bleeding were all accurately reported in >99% of cases. Most PPH-related data items in the 2011 VPDC may be considered reliable. Our results suggest EBL ≥ 1500 mL is likely to be under-reported. Changes to policies and practices of recording blood loss could further increase accuracy of reporting. © 2017 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.

  18. The cosmic infrared background experiment-2 (CIBER-2) for studying the near-infrared extragalactic background light

    Science.gov (United States)

    Shirahata, Mai; Arai, Toshiaki; Battle, John; Bock, James; Cooray, Asantha; Enokuchi, Akito; Hristov, Viktor; Kanai, Yoshikazu; Kim, Min Gyu; Korngut, Phillip; Lanz, Alicia; Lee, Dae-Hee; Mason, Peter; Matsumoto, Toshio; Matsuura, Shuji; Morford, Tracy; Ohnishi, Yosuke; Park, Won-Kee; Sano, Kei; Takeyama, Norihide; Tsumura, Kohji; Wada, Takehiko; Wang, Shiang-Yu; Zemcov, Michael

    2016-07-01

    We present the current status of the Cosmic Infrared Background ExpeRiment-2 (CIBER-2) project, whose goal is to make a rocket-borne measurement of the near-infrared Extragalactic Background Light (EBL), under a collaboration with U.S.A., Japan, South Korea, and Taiwan. The EBL is the integrated light of all extragalactic sources of emission back to the early Universe. At near-infrared wavelengths, measurement of the EBL is a promising way to detect the diffuse light from the first collapsed structures at redshift z˜10, which are impossible to detect as individual sources. However, recently, the intra-halo light (IHL) model is advocated as the main contribution to the EBL, and our new result of the EBL fluctuation from CIBER-1 experiment is also supporting this model. In this model, EBL is contributed by accumulated light from stars in the dark halo regions of low- redshift (zCIBER- 1 experiment, we are now developing a new instrument CIBER-2, which is comprised of a 28.5-cm aluminum telescope and three broad-band, wide-field imaging cameras. The three wide-field (2.3×2.3 degrees) imaging cameras use the 2K×2K HgCdTe HAWAII-2RG arrays, and cover the optical and near-infrared wavelength range of 0.5-0.9 μm, 1.0-1.4 μm and 1.5-2.0 μm, respectively. Combining a large area telescope with the high sensitivity detectors, CIBER-2 will be able to measure the spatial fluctuations in the EBL at much fainter levels than those detected in previous CIBER-1 experiment. Additionally, we will use a linear variable filter installed just above the detectors so that a measurement of the absolute spectrum of the EBL is also possible. In this paper, the scientific motivation and the expected performance for CIBER-2 will be presented. The detailed designs of the telescope and imaging cameras will also be discussed, including the designs of the mechanical, cryogenic, and electrical systems.

  19. Delayed-onset enzootic bovine leukosis possibly caused by superinfection with bovine leukemia virus mutated in the pol gene.

    Science.gov (United States)

    Watanabe, Tadaaki; Inoue, Emi; Mori, Hiroshi; Osawa, Yoshiaki; Okazaki, Katsunori

    2015-08-01

    Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis (EBL), to which animals are most susceptible at 4-8 years of age. In this study, we examined tumor cells associated with EBL in an 18-year-old cow to reveal that the cells carried at least two different copies of the virus, one of which was predicted to encode a reverse transcriptase (RT) lacking ribonuclease H activity and no integrase. Such a deficient enzyme may exhibit a dominant negative effect on the wild-type RT and cause insufficient viral replication, resulting in delayed tumor development in this cow.

  20. Interconnection of specific nano-objects by electron beam lithography - A controllable method

    Energy Technology Data Exchange (ETDEWEB)

    Della Torre, A. [National Nanotechnology Laboratory of CNR-INFM, Technological District, ISUFI, University of Lecce, Via per Arnesano, km 5, I-73100, Lecce (Italy)], E-mail: antonio.dellatorre@unile.it; Pompa, P.P.; Mercato, L.L. del; Chiuri, R.; Krahne, R.; Maruccio, G.; Carbone, L.; Manna, L.; Cingolani, R.; Rinaldi, R. [National Nanotechnology Laboratory of CNR-INFM, Technological District, ISUFI, University of Lecce, Via per Arnesano, km 5, I-73100, Lecce (Italy); Shankar, S. Shiv; Sastry, M. [Tata Chemicals Innovation Centre, Pune 411 045 (India)

    2008-03-10

    We report a widely applicable and highly controlled approach, based on electron beam lithography (EBL), to interconnect single nano-objects, previously immobilized onto solid surfaces, and to investigate the transport properties at the level of single nanostructures. In particular, a three-step EBL-procedure was used for this purpose by patterning two planar contacts on the sides of an individual nano-object. To demonstrate this approach, we use two different kinds of active elements: a semiconductor nanocrystal (tetrapod) and a thin triangular gold nanoprism (NT)

  1. Graphene antidot lattice transport measurements

    DEFF Research Database (Denmark)

    Mackenzie, David; Cagliani, Alberto; Gammelgaard, Lene

    2017-01-01

    for antidot arrays devices. Graphene devices were fabricated using 100 keV electron beam lithography (EBL) for nanopatterning as well as for defining electrical contacts. Patterns with hole diameter and neck widths of order 30 nm were produced, which is the highest reported pattern density of antidot lattices...... in graphene reported defined by EBL. Electrical measurements showed that devices with one and five rows exhibited field effect mobility of ∼100 cm2/Vs, while a larger number of rows, around 40, led to a significant reduction of field effect mobility (

  2. Performance enhancement of InGaN LEDs with Al-graded GaN/AlGaN multiple electron-blocking layers

    Science.gov (United States)

    Yeh, Yu-Hsiang; Yang, Chyi-Da; Lee, Chong-Yi; Tseng, Ying-Chen; Tsai, Jeng-Da

    2017-06-01

    The characteristics of InGaN-based flip-chip light-emitting diodes (LEDs) with Al-graded-composition GaN/AlGaN multiple electron-blocking layers (MEBLs) are investigated. Results showed that MEBL LED samples with differently graded Al mole fractions possess a higher light output power and a lower efficiency droop than a conventional EBL LED while avoiding the operating voltage penalty. These improvements are mainly attributed to the improvements in electron confinement and hole injection efficiency caused by mitigating the polarization-induced band-bending effect at the interface between the last barrier of multiple quantum wells and the EBL.

  3. Thin-film optical shutter. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Matlow, S.L.

    1981-02-01

    A specific embodiment of macroconjugated macromolecules, the poly (p-phenylene)'s, has been chosen as the one most likely to meet all of the requirements of the Thin Film Optical Shutter project (TFOS). The reason for this choice is included. In order to be able to make meaningful calculations of the thermodynamic and optical properties of the poly (p-phenylene)'s a new quantum mechanical method was developed - Equilibrium Bond Length (EBL) Theory. Some results of EBL Theory are included.

  4. De novo mutations in Plxnd1 and Rev3l cause mobius syndrome

    OpenAIRE

    Kayserili Karabey, Hülya; Tomas-Roca, Laura; Tsaalbi-Shtylik, Anastasia; Jansen, Jacob G.; Singh, Manvendra K.; Epstein, Jonathan A.; Altunoglu, Umut; Verzijl, Harriette; Soria, Laura; van Beusekom, Ellen; Roscioli, Tony; Iqbal, Zafar; Gilissen, Christian; Hoischen, Alexander; de Brouwer,Arjan P. M.; Erasmus, Corrie; Schubert, Dirk; Brunner, Han; Aytes, Antonio Perez; Marin, Faustino; Aroca, Pilar; Carta, Arturo; de Wind, Niels; Padberg, George W.; van Bokhoven, Hans

    2015-01-01

    ARTICLE Received 15 Nov 2014 | Accepted 17 Apr 2015 | Published 12 Jun 2015 De novo mutations in PLXND1 and REV3L cause Mo¨bius syndrome Laura Tomas-Roca1,2, Anastasia Tsaalbi-Shtylik3, Jacob G. Jansen3, Manvendra K. Singh4,5, Jonathan A. Epstein4, Umut Altunoglu6, Harriette Verzijl7, Laura Soria1, Ellen van Beusekom1, Tony Roscioli1,8, Zafar Iqbal1, Christian Gilissen1, Alexander Hoischen9, Arjan P.M. de Brouwer1, Corrie Erasmus7, Dirk Schubert10, Han Brunner1,11, Antoni...

  5. Igal pool ja mitte kuskil / Piibe Piirma

    Index Scriptorium Estoniae

    Piirma, Piibe

    2006-01-01

    Võrgu- ehk netikunsti ajaloost ja arengust. Korea kunstniku Nam June Paiki, Vene kunstnike Aleksei Shulgini ja Olja Ljalina, hollandi fotograafi Joan Heemskerk'i, belgia kunstniku Dirk Paesmans'i, sloveeni kunstnike Vuk Cosic'i ja Marko Pelijhan'i, kanada kunstniku Robert Adrian X-i, saksa kunstnike Wolfgang Staehle, Rena Tangens'i ja Cornelia Sollfranki tegevusest. Šveitsi kunstirühmituse "Etoy" performance'ist "Toywar". Lühidalt eesti võrgukunstist, Mare Tralla ja Tiia Johannsoni tegevusest. Repliigid Heie Treierilt ja Raivo Kelomehelt

  6. An Autonomous Orbit Determination System for Earth Satellites

    Science.gov (United States)

    1989-12-01

    these points is warranted. For example, low-Earth orbits ( LEO ) can be expected to approach e - 0 with time, so it is particularly useful to examine how...0.77887 e + 0.52875 e x y z 7 Canis Major A A A Cairs) M-0.18485 e + 0.93984 e - 0.28728 e (Sirus) -xyz A A A 8 a Leo -0.86275 e + 0.46061 e...Filters for Orbit Determination and Estimation, PhD Dissertation. University of Illinois, Urbana-Champaign IL, 1986 (AD-A170680). 12. Brouwer , Dirk

  7. Voluntary Medical Male Circumcision: A Cross-Sectional Study Comparing Circumcision Self-Report and Physical Examination Findings in Lesotho

    Science.gov (United States)

    2011-11-29

    During the physical examination, with a study nurse present, a medical doctor examined the penis for extent of circumcision, using a four-point scale...However, this does not appear to have biased the study results, as the average MC prevalence in the LDHS is similar across all men aged 20 y and older (57.9...Rakai, Uganda ( size matters). AIDS 23: 2209–2213. 24. Lagarde E, Dirk T, Puren A, Reathe RT, Bertran A (2003) Acceptability of male circumcision as a

  8. STS-45 payload specialists with crew escape system (CES) mockup at JSC's MAIL

    Science.gov (United States)

    1991-01-01

    STS-45 Atlantis, Orbiter Vehicle (OV) 104, Payload Specialist Dirk D. Frimout (European Space Agency (ESA) Belgian crewmember) (left), backup Payload Specialist Charles R. Chappell (center), and Payload Specialist Byron K. Lichtenberg (right) listen to technician explain the operation of the crew escape system (CES) pole. Frimout is engaging the handle which extends the CES pole out the side hatch. The payload specialists along with the other STS-45 crewmembers are participating in side hatch emergency egress exercises in JSC's Mockup and Integration Laboratory (MAIL) Bldg 9A.

  9. Stemcell Information: SKIP001188 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available B. Dirks 多形膠芽腫患者の腫瘍細胞由来の神経膠芽腫幹細胞 Arthur and Sonia Labatt Brain Tumor Research Center and Developmental and S...tem Cell Biology, The Hospital for Sick Children (SickKids) Arthur and Sonia Laba...tt Brain Tumor Research Center and Developmental and Stem Cell Biology, The Hospital for Sick Children (SickKids) Arthur...tal for Sick Children (SickKids) Arthur and Sonia Labatt Brain Tumor Research Cen

  10. Igal pool ja mitte kuskil / Piibe Piirma

    Index Scriptorium Estoniae

    Piirma, Piibe

    2006-01-01

    Võrgu- ehk netikunsti ajaloost ja arengust. Korea kunstniku Nam June Paiki, Vene kunstnike Aleksei Shulgini ja Olja Ljalina, hollandi fotograafi Joan Heemskerk'i, belgia kunstniku Dirk Paesmans'i, sloveeni kunstnike Vuk Cosic'i ja Marko Pelijhan'i, kanada kunstniku Robert Adrian X-i, saksa kunstnike Wolfgang Staehle, Rena Tangens'i ja Cornelia Sollfranki tegevusest. Šveitsi kunstirühmituse "Etoy" performance'ist "Toywar". Lühidalt eesti võrgukunstist, Mare Tralla ja Tiia Johannsoni tegevusest. Repliigid Heie Treierilt ja Raivo Kelomehelt

  11. Nonlinear mechanics a supplement to theoretical mechanics of particles and continua

    CERN Document Server

    Fetter, Alexander L

    2006-01-01

    In their prior Dover book, Theoretical Mechanics of Particles and Continua, Alexander L. Fetter and John Dirk Walecka provided a lucid and self-contained account of classical mechanics, together with appropriate mathematical methods. This supplement-an update of that volume-offers a bridge to contemporary mechanics.The original book's focus on continuum mechanics-with chapters on sound waves in fluids, surface waves on fluids, heat conduction, and viscous fluids-forms the basis for this supplement's discussion of nonlinear continuous systems. Topics include linearized stability analysis; a det

  12. Geological and taphonomic context for the new hominin species Homo naledi from the Dinaledi Chamber, South Africa

    OpenAIRE

    Dirks, Paul, H.G.M; Berger, Lee; Roberts, Eric; Kramers, Jan; Hawks, John; Randolph-Quinney, Patrick; Elliott, Marina; Musiba, Charles; Churchill, Steven, E.; de Ruiter, Darryl, J.; Schmid, Peter; Backwell, Lucinda, R.; Belyanin, Georgy, A.; Boshoff, Pedro; Hunter, Lyndsay, K.

    2015-01-01

    eLife digest Modern humans, or Homo sapiens, are now the only living species in their genus. But as recently as 20,000 years ago there were other species that belonged to the genus Homo. Together with modern humans, these extinct human species, our immediate ancestors and their close relatives are collectively referred to as ‘hominins’. Now, Dirks et al. describe an unusual collection of hominin fossils that were found within the Dinaledi Chamber in the Rising Star cave system in South Africa...

  13. Clinical significance of peripheral blood erythroblastosis after hematopoietic stem cell transplantation.

    Science.gov (United States)

    Goyama, Susumu; Kanda, Yoshinobu; Nannya, Yasuhito; Ogawa, Seishi; Asano-Moki, Yuki; Ogawa, Natsu; Nakagawa, Masahiro; Sakata-Yanagimoto, Mamiko; Kawazu, Masahito; Komeno, Yukiko; Imai, Yoichi; Hangaishi, Akira; Kurokawa, Mineo; Tsujino, Shiho; Aoki, Katsunori; Chiba, Shigeru; Motokura, Toru; Hirai, Hisamaru

    2004-12-01

    Erythroblasts (EBL) are normally not observed in peripheral blood, but may be found in patients suffering from a variety of severe diseases. The detection of EBL in peripheral blood has been shown to be associated with a poor prognosis. However, the clinical significance of peripheral erythroblastosis after hematopoietic stem cell transplantation (HSCT) has not been evaluated. We retrospectively analyzed the records of 161 patients who underwent HSCT at our hospital from June 1995 to October 2001. EBL at any level were detected in 94% of the patients. Forty-four and 11 patients experienced erythroblastosis exceeding 200 and 1,000/ul, respectively. The erythroblast count was higher in patients who died than in the survivors (geometric mean value 184 vs. 100/ul, P=0.01). High-level erythroblastosis ( >1,000/ul) within 180 days after HSCT was associated with an extremely poor prognosis (median survival 22.5 days). Among the possible confounding factors, the use of total body irradiation (RR 2.35, 95% CI 1.22 - 4.54, P=0.011) and the disease status before transplantation (RR 2.51, 95% CI 1.15 - 5.49, P=0.021) were independent significant factors for erythroblastosis after HSCT. As for post-transplant events, a high EBL concentration was frequently preceded by graft-vs.-host disease, thrombotic microangiopathy, hypoxia, and hematological relapse.

  14. E-Books in the Sciences: If We Buy It Will They Use It?

    Science.gov (United States)

    Nariani, Rajiv

    2009-01-01

    York University, Toronto, Canada has been acquiring e-books from different publishers and content providers. At present our University subscribes to electronic content from NetLibrary, ebrary, EBL, Oxford Scholarship Online, Oxford Reference Online, MyiLibrary, Safari, Springer, Oxford University Press, Knovel, Books24x7, Synthesis Engineering…

  15. E-Books in the Sciences: If We Buy It Will They Use It?

    Science.gov (United States)

    Nariani, Rajiv

    2009-01-01

    York University, Toronto, Canada has been acquiring e-books from different publishers and content providers. At present our University subscribes to electronic content from NetLibrary, ebrary, EBL, Oxford Scholarship Online, Oxford Reference Online, MyiLibrary, Safari, Springer, Oxford University Press, Knovel, Books24x7, Synthesis Engineering…

  16. High speed e-beam writing for large area photonic nanostructures — a choice of parameters

    Science.gov (United States)

    Li, Kezheng; Li, Juntao; Reardon, Christopher; Schuster, Christian S.; Wang, Yue; Triggs, Graham J.; Damnik, Niklas; Müenchenberger, Jana; Wang, Xuehua; Martins, Emiliano R.; Krauss, Thomas F.

    2016-09-01

    Photonic nanostructures are used for many optical systems and applications. However, some high-end applications require the use of electron-beam lithography (EBL) to generate such nanostructures. An important technological bottleneck is the exposure time of the EBL systems, which can exceed 24 hours per 1 cm2. Here, we have developed a method based on a target function to systematically increase the writing speed of EBL. As an example, we use as the target function the fidelity of the Fourier Transform spectra of nanostructures that are designed for thin film light trapping applications, and optimize the full parameter space of the lithography process. Finally, we are able to reduce the exposure time by a factor of 5.5 without loss of photonic performance. We show that the performances of the fastest written structures are identical to the original ones within experimental error. As the target function can be varied according to different purposes, the method is also applicable to guided mode resonant grating and many other areas. These findings contribute to the advancement of EBL and point towards making the technology more attractive for commercial applications.

  17. The Strategic Development of Learner Autonomy through Enquiry-Based Learning: A Case Study

    Science.gov (United States)

    Bramhall, Mike D.; Lewis, Justin; Norcliffe, Allan; Radley, Keith; Waldock, Jeff

    2010-01-01

    This paper reports on strategic developments to enhance student learner autonomy skills through the use of enquiry-based learning (EBL) in the design of higher education programmes. The UK's Sheffield Hallam University is a recognized Centre of Excellence in Teaching and Learning (CETL) in the field of developing learner autonomy. Central to the…

  18. A new mask exposure and analysis facility

    NARCIS (Netherlands)

    Sligte, E. te; Koster, N.B.; Deutz, A.F.; Staring, W.P.M.

    2014-01-01

    The introduction of ever higher source powers in EUV systems causes increased risks for contamination and degradation of EUV masks and pellicles. Appropriate testing can help to inventory and mitigate these risks. To this end, we propose EBL2: a laboratory EUV exposure system capable of operating at

  19. Dots-on-the-fly electron beam lithography

    Science.gov (United States)

    Isotalo, Tero J.; Niemi, Tapio

    2016-03-01

    We demonstrate a novel approach for electron-beam lithography (EBL) of periodic nanostructures. This technique can rapidly produce arrays of various metallic and etched nanostructures with line and pitch dimensions approaching the beam spot size. Our approach is based on often neglected functionality which is inherent in most modern EBL systems. The raster/vector beam exposure system of the EBL software is exploited to produce arrays of pixel-like spots without the need to define coordinates for each spot in the array. Producing large arrays with traditional EBL techniques is cumbersome during pattern design, usually leads to large data files and easily results in system memory overload during patterning. In Dots-on-the-fly (DOTF) patterning, instead of specifying the locations of individual spots, a boundary for the array is given and the spacing between spots within the boundary is specified by the beam step size. A designed pattern element thus becomes a container object, with beam spacing acting as a parameterized location list for an array of spots confined by that container. With the DOTF method, a single pattern element, such as a square, rectangle or circle, can be used to produce a large array containing thousands of spots. In addition to simple arrays of nano-dots, we expand the technique to produce more complex, highly tunable arrays and structures on substrates of silicon, ITO/ FTO coated glass, as well as uncoated fused silica, quartz and sapphire.

  20. The effect of emissive biased limiter on the magnetohydrodynamic modes in the IR-T1 tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Ghasemloo, M.; Ghoranneviss, M.; Salem, M. K.; Arvin, R.; Mohammadi, S.; Nik Mohammadi, A. [Plasma Physics Research Center, Science and Research Branch, Islamic Azad University, P. O. Box 14665-678, Tehran (Iran, Islamic Republic of)

    2013-03-15

    A moveable emissive biased limiter (EBL) for the investigation of spatial and temporal structure of MHD modes in IR-T1 tokamak, based on mirnov oscillations, was designed and constructed. The biasing has been considered to improve the global confinement by setting up an electric field at the plasma edge. Radial electric field (E{sub r}) modifies edge plasma turbulence, plasma rotation, and transport. Mirnov oscillations using singular value decomposition (SVD) and wavelet techniques were analyzed. SVD algorithm has been employed to analyze the frequency and wavenumber harmonics of the MHD fluctuations. The time-resolved frequency component analysis has been performed using wavelets. The EBL was applied to plasma at 10 ms with negative polarity. The results show that after applying EBL, the m = 2 mode is grown, m = 3 mode is suppressed, and H{sub {alpha}} radiation is decreased. Furthermore, results of the wavelet analysis of mirnov coil in the time range of 8-12 ms indicate that 1.5 ms after applying EBL, the MHD frequency is reduced from 45 kHz to 25 kHz.

  1. Wikipedia : sama täpne kui päris teatmeteos / Aivar Õepa

    Index Scriptorium Estoniae

    Õepa, Aivar, 1967-

    2005-01-01

    2001. aastal asutatud Wikipedia (www.wikipedia.org) on vabatahtlike tööl põhinev interneti-teatmeteos. Wikipediat ja Encyclopedia Britannicat võrrelnud teadlased leidsid, et veebientsüklopeedia ei jää täpsuses EB-le alla

  2. High speed e-beam writing for large area photonic nanostructures - a choice of parameters.

    Science.gov (United States)

    Li, Kezheng; Li, Juntao; Reardon, Christopher; Schuster, Christian S; Wang, Yue; Triggs, Graham J; Damnik, Niklas; Müenchenberger, Jana; Wang, Xuehua; Martins, Emiliano R; Krauss, Thomas F

    2016-09-16

    Photonic nanostructures are used for many optical systems and applications. However, some high-end applications require the use of electron-beam lithography (EBL) to generate such nanostructures. An important technological bottleneck is the exposure time of the EBL systems, which can exceed 24 hours per 1 cm(2). Here, we have developed a method based on a target function to systematically increase the writing speed of EBL. As an example, we use as the target function the fidelity of the Fourier Transform spectra of nanostructures that are designed for thin film light trapping applications, and optimize the full parameter space of the lithography process. Finally, we are able to reduce the exposure time by a factor of 5.5 without loss of photonic performance. We show that the performances of the fastest written structures are identical to the original ones within experimental error. As the target function can be varied according to different purposes, the method is also applicable to guided mode resonant grating and many other areas. These findings contribute to the advancement of EBL and point towards making the technology more attractive for commercial applications.

  3. Lateral retroperitoneoscopic adrenalectomy for complicated adrenal ...

    African Journals Online (AJOL)

    LRA was shorter than OA (98.7±32.3 min vs 152.7±72.3 min, P = 0.001). EBL was 31.9±20.0 ..... fit from more visibility and larger working space, as well as most familiar .... Best practice & research Clinical endocrinology & metabolism, 2001,.

  4. An Analysis of English Business Letters from the Perspective of Interpersonal Function

    Science.gov (United States)

    Xu, Bo

    2012-01-01

    The purpose of the present study is to find out the features of English business letters. Halliday's systemic functional linguistics is used as the theoretical framework, mainly, interpersonal fucntion. The English business letter (EBL) is an important written text used for international business communication and it has its own features of text.…

  5. Resist and Exposure Processes for Sub-10-nm Electron and Ion Beam Lithography

    NARCIS (Netherlands)

    Sidorkin, V.A.

    2010-01-01

    The research work described in this thesis deals with studying the ultimate resolution capabilities of electron and ion beam lithography (EBL and IBL respectively) with a focus on resist and exposure processes. The aim of this research was to enlarge knowledge and improve methods on the formation of

  6. Developing evidence-based librarianship: practical steps for implementation.

    Science.gov (United States)

    Crumley, Ellen; Koufogiannakis, Denise

    2002-06-01

    Evidence-based librarianship (EBL) is a relatively new concept for librarians. This paper lays out a practical framework for the implementation of EBL. A new way of thinking about research in librarianship is introduced using the well-built question process and the assignment of librarian research questions to one of six domains specific to librarianship. As a profession, librarianship tends to reflect more qualitative, social sciences/humanities in its research methods and study types which tend to be less rigorous and more prone to bias. Randomised controlled trials (RCT) do not have to be placed at the top of an evidence 'hierarchy' for librarianship. Instead, a more encompassing model reflecting librarianship as a whole and the kind of research likely to be done by librarians is proposed. 'Evidence' from a number of disciplines including health sciences, business and education can be utilized by librarians and applied to their practice. However, access to and availability of librarianship literature needs to be further studied. While using other disciplines (e.g. EBHC) as a model for EBL has been explored in the literature, the authors develop models unique to librarianship. While research has always been a minor focus in the profession, moving research into practice is becoming more important and librarians need to consider the issues surrounding research in order to move EBL forward.

  7. 40 CFR 745.223 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... trainees' knowledge and retention of the topics covered during the course. Course test blue print means... soil. Elevated blood lead level (EBL) means an excessive absorption of lead that is a confirmed concentration of lead in whole blood of 20 µg/dl (micrograms of lead per deciliter of whole blood) for a single...

  8. Extragalactic Background Light and Gamma-Ray Attenuation

    CERN Document Server

    Primack, Joel R; Gilmore, Rudy C; Somerville, Rachel S

    2011-01-01

    Data from (non-) attenuation of gamma rays from active galactic nuclei (AGN) and gamma ray bursts (GRBs) give upper limits on the extragalactic background light (EBL) from the UV to the mid-IR that are only a little above the lower limits from observed galaxies. These upper limits now rule out some EBL models and purported observations, with improved data likely to provide even stronger constraints. We present EBL calculations both based on multiwavelength observations of thousands of galaxies and also based on semi-analytic models, and show that they are consistent with these lower limits from observed galaxies and with the gamma-ray upper limit constraints. Such comparisons "close the loop" on cosmological galaxy formation models, since they account for all the light, including that from galaxies too faint to see. We compare our results with those of other recent works, and discuss the implications of these new EBL calculations for gamma ray attenuation. Catching a few GRBs with groundbased atmospheric Cher...

  9. ORNL Evaluation of Electrabel Safety Cases for Doel 3 / Tihange 2: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Bass, Bennett Richard [ORNL; Dickson, Terry L [ORNL; Gorti, Sarma B [ORNL; Klasky, Hilda B [ORNL; Nanstad, Randy K [ORNL; Sokolov, Mikhail A [ORNL; Williams, Paul T [ORNL; Server, W. L. [ATI Consulting, Pinehurst, NC

    2015-11-01

    Oak Ridge National Laboratory (ORNL) performed a detailed technical review of the 2015 Electrabel (EBL) Safety Cases prepared for the Belgium reactor pressure vessels (RPVs) at Doel 3 and Tihange 2 (D3/T2). The Federal Agency for Nuclear Control (FANC) in Belgium commissioned ORNL to provide a thorough assessment of the existing safety margins against cracking of the RPVs due to the presence of almost laminar flaws found in each RPV. Initial efforts focused on surveying relevant literature that provided necessary background knowledge on the issues related to the quasilaminar flaws observed in D3/T2 reactors. Next, ORNL proceeded to develop an independent quantitative assessment of the entire flaw population in the two Belgian reactors according to the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code, Section XI, Appendix G, Fracture Toughness Criteria for Protection Against Failure, New York (1992 and 2004). That screening assessment of all EBL-characterized flaws in D3/T2 used ORNL tools, methodologies, and the ASME Code Case N-848, Alternative Characterization Rules for QuasiLaminar Flaws . Results and conclusions from the ORNL flaw acceptance assessments of D3/T2 were compared with those from the 2015 EBL Safety Cases. Specific findings of the ORNL evaluation of that part of the EBL structural integrity assessment focusing on stability of the flaw population subjected to primary design transients include the following: ORNL s analysis results were similar to those of EBL in that very few characterized flaws were found not compliant with the ASME (1992) acceptance criterion. ORNL s application of the more recent ASME Section XI (2004) produced only four noncompliant flaws, all due to LOCAs. The finding of a greater number of non-compliant flaws in the EBL screening assessment is due principally to a significantly more restrictive (conservative) criterion for flaw size acceptance used by EBL. ORNL s screening assessment results

  10. A Mini-Library of Sequenced Human DNA Fragments: Linking Bench Experiments with Informatics

    Science.gov (United States)

    Dalgleish, Raymond; Shanks, Morag E.; Monger, Karen; Butler, Nicola J.

    2012-01-01

    We describe the development of a mini-library of human DNA fragments for use in an enquiry-based learning (EBL) undergraduate practical incorporating "wet-lab" and bioinformatics tasks. In spite of the widespread emergence of the polymerase chain reaction (PCR), the cloning and analysis of DNA fragments in "Escherichia coli"…

  11. Wikipedia : sama täpne kui päris teatmeteos / Aivar Õepa

    Index Scriptorium Estoniae

    Õepa, Aivar, 1967-

    2005-01-01

    2001. aastal asutatud Wikipedia (www.wikipedia.org) on vabatahtlike tööl põhinev interneti-teatmeteos. Wikipediat ja Encyclopedia Britannicat võrrelnud teadlased leidsid, et veebientsüklopeedia ei jää täpsuses EB-le alla

  12. The Impact of Enquiry-Based Learning on Academic Performance and Student Engagement

    Science.gov (United States)

    Summerlee, Alastair; Murray, Jacqueline

    2010-01-01

    Previously, we reported qualitative findings showing that students who experienced a problem- or enquiry-based course (EBL) in a first-year seminar program had greater confidence in their academic abilities, were more engaged, and were better prepared for upper-year courses. In the current paper, we provide quantitative data to substantiate the…

  13. Enquiry-Based Learning and Formative Assessment Environments: Student Perspectives

    Science.gov (United States)

    Sambell, Kay

    2010-01-01

    This paper outlines case study research into first-year students' experiences of enquiry-based learning (EBL) on a year-long introductory theory module. Students were supported to carry out a series of authentic small-scale enquiries involving: (1) working in research teams; (2) gathering, disseminating and analysing data from the field; (3)…

  14. A Mini-Library of Sequenced Human DNA Fragments: Linking Bench Experiments with Informatics

    Science.gov (United States)

    Dalgleish, Raymond; Shanks, Morag E.; Monger, Karen; Butler, Nicola J.

    2012-01-01

    We describe the development of a mini-library of human DNA fragments for use in an enquiry-based learning (EBL) undergraduate practical incorporating "wet-lab" and bioinformatics tasks. In spite of the widespread emergence of the polymerase chain reaction (PCR), the cloning and analysis of DNA fragments in "Escherichia coli"…

  15. The Strategic Development of Learner Autonomy through Enquiry-Based Learning: A Case Study

    Science.gov (United States)

    Bramhall, Mike D.; Lewis, Justin; Norcliffe, Allan; Radley, Keith; Waldock, Jeff

    2010-01-01

    This paper reports on strategic developments to enhance student learner autonomy skills through the use of enquiry-based learning (EBL) in the design of higher education programmes. The UK's Sheffield Hallam University is a recognized Centre of Excellence in Teaching and Learning (CETL) in the field of developing learner autonomy. Central to the…

  16. Impact on the Student Experience of Extending Problem-Based and Enquiry-Based Learning

    Science.gov (United States)

    Reynolds, Rysia; Saxon, David; Benmore, Graham

    2006-01-01

    This article reports on extended research into the use of enquiry-based learning (EBL) and problem-based learning (PBL) in a human resource management undergraduate programme. The authors have collected and analysed qualitative and quantitative data over a three-year period, some of which have been previously reported (Reynolds and Benmore, 2003,…

  17. eBooks Corp partners with the home of the world wide web

    CERN Multimedia

    2003-01-01

    eBooks Corporation announced that it is collaborating with leading international university and research libraries, including CERN, to develop an eBook lending platform. eBook Library or "EBL" is scheduled for release in select sites in September 2003 and will be officially launched in January 2004 (1/2 Ppage).

  18. Selective activation of TCR-G¿ cells in endemic Burkitt's lymphoma

    DEFF Research Database (Denmark)

    Futagbi, Godfred; Welbeck, Jennifer E; Tetteh, John Kweku A

    2007-01-01

    composition and activation status in P. falciparum-exposed Ghanaian children with and without eBL. METHODS: Venous blood samples in heparin from 21 eBL patients (mean age: 7.0 years; range: 3-11 years), referred to the Burkitt's Tumour Centre at Korle-Bu Teaching Hospital, Accra and 15 healthy, age and sex...... in the proportion of CD3+ cells in eBL patients, due mainly to perturbations among TCR-gammadelta+ cells was observed. In contrast, the proportions of CD4+ or CD8+ cells were relatively unaffected, as were the mean numbers of peripheral blood mononuclear cells. CONCLUSION: Selective changes in numbers...... and activation status of TCR-gammadelta+ cells occurs in Ghanaian children with eBL, a pattern which is similar to P. falciparum-induced changes. The data supports the hypothesis of a regulatory role for Vdelta1+ TcR-gammadelta T-cells in maintaining B-cell homeostasis and provides insights into the pathogenesis...

  19. ORNL Evaluation of Electrabel Safety Cases for Doel 3 / Tihange 2: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Bass, Bennett Richard [ORNL; Dickson, Terry L [ORNL; Gorti, Sarma B [ORNL; Klasky, Hilda B [ORNL; Nanstad, Randy K [ORNL; Sokolov, Mikhail A [ORNL; Williams, Paul T [ORNL; Server, W. L. [ATI Consulting, Pinehurst, NC

    2015-11-01

    Oak Ridge National Laboratory (ORNL) performed a detailed technical review of the 2015 Electrabel (EBL) Safety Cases prepared for the Belgium reactor pressure vessels (RPVs) at Doel 3 and Tihange 2 (D3/T2). The Federal Agency for Nuclear Control (FANC) in Belgium commissioned ORNL to provide a thorough assessment of the existing safety margins against cracking of the RPVs due to the presence of almost laminar flaws found in each RPV. Initial efforts focused on surveying relevant literature that provided necessary background knowledge on the issues related to the quasilaminar flaws observed in D3/T2 reactors. Next, ORNL proceeded to develop an independent quantitative assessment of the entire flaw population in the two Belgian reactors according to the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code, Section XI, Appendix G, Fracture Toughness Criteria for Protection Against Failure, New York (1992 and 2004). That screening assessment of all EBL-characterized flaws in D3/T2 used ORNL tools, methodologies, and the ASME Code Case N-848, Alternative Characterization Rules for QuasiLaminar Flaws . Results and conclusions from the ORNL flaw acceptance assessments of D3/T2 were compared with those from the 2015 EBL Safety Cases. Specific findings of the ORNL evaluation of that part of the EBL structural integrity assessment focusing on stability of the flaw population subjected to primary design transients include the following: ORNL s analysis results were similar to those of EBL in that very few characterized flaws were found not compliant with the ASME (1992) acceptance criterion. ORNL s application of the more recent ASME Section XI (2004) produced only four noncompliant flaws, all due to LOCAs. The finding of a greater number of non-compliant flaws in the EBL screening assessment is due principally to a significantly more restrictive (conservative) criterion for flaw size acceptance used by EBL. ORNL s screening assessment results

  20. CONSTRAINTS ON THE INTERGALACTIC MAGNETIC FIELD WITH GAMMA-RAY OBSERVATIONS OF BLAZARS

    Energy Technology Data Exchange (ETDEWEB)

    Finke, Justin D. [U.S. Naval Research Laboratory, Code 7653, 4555 Overlook Ave. SW, Washington, DC 20375-5352 (United States); Reyes, Luis C.; Reynolds, Kaeleigh [Department of Physics, California Polytechnic State University, San Luis Obispo, CA 93401 (United States); Georganopoulos, Markos; McCann, Kevin [Department of Physics and Center for Space Sciences and Technology, University of Maryland Baltimore County, Baltimore, MD 21250 (United States); Ajello, Marco [Department of Physics and Astronomy, Clemson University, Kinard Lab of Physics, Clemson, SC 29634-0978 (United States); Fegan, Stephen J., E-mail: justin.finke@nrl.navy.mil, E-mail: lreyes04@calpoly.edu, E-mail: georgano@umbc.edu [Laboratoire Leprince-Ringuet, École polytechnique, CNRS/IN2P3, Palaiseau (France)

    2015-11-20

    Distant BL Lacertae objects emit γ-rays that interact with the extragalactic background light (EBL), creating electron–positron pairs, and reducing the flux measured by ground-based imaging atmospheric Cherenkov telescopes (IACTs) at very-high energies (VHE). These pairs can Compton-scatter the cosmic microwave background, creating a γ-ray signature at slightly lower energies that is observable by the Fermi Large Area Telescope (LAT). This signal is strongly dependent on the intergalactic magnetic field (IGMF) strength (B) and its coherence length (L{sub B}). We use IACT spectra taken from the literature for 5 VHE-detected BL Lac objects and combine them with LAT spectra for these sources to constrain these IGMF parameters. Low B values can be ruled out by the constraint that the cascade flux cannot exceed that observed by the LAT. High values of B can be ruled out from the constraint that the EBL-deabsorbed IACT spectrum cannot be greater than the LAT spectrum extrapolated into the VHE band, unless the cascade spectrum contributes a sizable fraction of the LAT flux. We rule out low B values (B ≲ 10{sup −19} G for L{sub B} ≥ 1 Mpc) at >5σ in all trials with different EBL models and data selection, except when using >1 GeV spectra and the lowest EBL models. We were not able to constrain high values of B.

  1. Resist and Exposure Processes for Sub-10-nm Electron and Ion Beam Lithography

    NARCIS (Netherlands)

    Sidorkin, V.A.

    2010-01-01

    The research work described in this thesis deals with studying the ultimate resolution capabilities of electron and ion beam lithography (EBL and IBL respectively) with a focus on resist and exposure processes. The aim of this research was to enlarge knowledge and improve methods on the formation of

  2. A Comparison of Radical Perineal, Radical Retropubic, and Robot-Assisted Laparoscopic Prostatectomies in a Single Surgeon Series

    Directory of Open Access Journals (Sweden)

    Moben Mirza

    2011-01-01

    Full Text Available Objective. We sought to compare positive surgical margin rates (PSM, estimated blood loss (EBL, and quality of life outcomes (QOL among perineal (RPP, retropubic (RRP, and robot-assisted laparoscopic (RALP prostatectomies. Methods. Records from 463 consecutive men undergoing RPP (92, RRP (180, or RALP (191 for clinically localized prostate cancer were retrospectively reviewed. Age, percent tumor volume, Gleason score, stage, EBL, PSM, and QOL using the expanded prostate cancer index composite (EPIC were compared. Results. PSM were similar when adjusted for stage, grade, and volume. EBL was significantly less in the RALP (189 ml group compared to both RPP (475 ml and RRP (999 ml groups. When corrected for nerve sparing, there were no differences in erectile function and sexual function amongst the three groups. Urinary summary and pad usage scores showed no significant differences. Conclusion. RPP, RRP, and RALP offer similar surgical and QOL outcomes. RALP and RPP demonstrate less EBL compared to RRP.

  3. Use of a dual reporter plasmid to demonstrate Bactofection with an attenuated AroA(- derivative of Pasteurella multocida B:2.

    Directory of Open Access Journals (Sweden)

    Sarah Othman

    Full Text Available A reporter plasmid pSRG has been developed which expresses red fluorescent protein (RFP from a constitutive prokaryotic promoter within Pasteurella multocida B:2 and green fluorescent protein (GFP from a constitutive eukaryotic promoter within mammalian cells. This construct has been used to determine the location and viability of the bacteria when moving from the extracellular environment into the intracellular compartment of mammalian cells. Invasion assays with embryonic bovine lung (EBL cells and an attenuated AroA(- derivative of Pasteurella multocida B:2 (strain JRMT12, harbouring the plasmid pSRG, showed that RFP-expressing bacteria could be detected intracellularly at 3 h post-invasion. At this stage, some EBL cells harbouring RFP-expressing bacteria were observed to express GFP simultaneously, indicating release of the plasmid into the intracellular environment. At 5 h post-invasion, more EBL cells were expressing GFP, while still harbouring RFP-expressing bacteria. Concurrently, some EBL cells were shown to express only GFP, indicating loss of viable bacteria within these cells. These experiments proved the functionality of the pSRG dual reporter system and the potential of P. multocida B:2 JRMT12 for bactofection and delivery of a DNA vaccine.

  4. A new mask exposure and analysis facility

    NARCIS (Netherlands)

    Sligte, E. te; Koster, N.B.; Deutz, A.F.; Staring, W.P.M.

    2014-01-01

    The introduction of ever higher source powers in EUV systems causes increased risks for contamination and degradation of EUV masks and pellicles. Appropriate testing can help to inventory and mitigate these risks. To this end, we propose EBL2: a laboratory EUV exposure system capable of operating at

  5. Changing clinical picture of endemic Burkitt’s lymphoma with improved diagnostic technology: A systematic review

    Directory of Open Access Journals (Sweden)

    Kamulegeya A

    2015-07-01

    Full Text Available We evaluated the changes in anatomical locations of endemic Burkitt’s lymphoma (eBL by systematic review. We compared the reports before ultrasound became a routine investigation in Burkitt’s lymphoma (BL diagnosis with those that used ultrasound as part of pre therapeutic diagnosis. Methods: All alternative match terms able to capture the anatomical distribution of eBL were used as search terms for two electronic databases, namely Medline and “Web of Science”. Only reports that had reasonable case load were considered for analysis. However the case reports and case series with five or less patients were not included. Results: Medline produced more systematic review identified reports. The search terms “endemic Burkitt lymphoma Africa” yielded the highest number of articles in both databases but had a low precision, at 3.5. Pattern of organ involvement Burkitt lymphoma Africa had a precision at 100%. Medline recalled 27 reports that were not recalled by the Web of Science. Generally it appears that studies that have relied on laparotomies, autopsies and ultrasound have reported a higher abdominal involvement in eBL than those using clinical examination and plain radiographs. This points to the possibility of missed abdominal involvement due to diagnostic techniques. Conclusion: the review confirms that as more Sub Saharan African (SSA countries incorporate US as a routine investigation in management of eBL, we are likely to see more abdominal disease with or without facial manifestation

  6. Light sensors based on organic phototransistors with absorption-enhancing nanoparticles

    DEFF Research Database (Denmark)

    Runge Walther, Anders; Linnet, Jes; Albrektsen, Ole

    lithography (EBL) we have fabricated organic field effect transistors (OFETs) with arrays of silver NPs under the organic thin-film. Experimentally, the optical extinction of light incident on arrays of NPs has been measured by reflectance spectroscopy. The results have been compared to the predictions of Mie...

  7. Integrating nanotubes into microsystems with electron beam lithography and in situ catalytically activated growth

    DEFF Research Database (Denmark)

    Gjerde, Kjetil; Fornés-Mora, Marc; Kjelstrup-Hansen, Jakob

    2006-01-01

    the possibility of waferscale fabrication of such devices. We combine conventional microfabrication techniques with state of the art electron beam lithography (EBL) to precisely position catalyst nanoparticles with sub 100 nm diameter into the microsystems. In particular, we have explored two main approaches...

  8. Toward a scalable flexible-order model for 3D nonlinear water waves

    DEFF Research Database (Denmark)

    Engsig-Karup, Allan Peter; Ducrozet, Guillaume; Bingham, Harry B.

    strategy on a time-invariant mesh. The 3D numerical model is based on a finite difference method as in the original works \\cite{LiFleming1997,BinghamZhang2007}. Full details and other aspects of an improved 3D solution can be found in \\cite{EBL08}. The new and improved approach for three...

  9. Plasmonic colour laser printing

    DEFF Research Database (Denmark)

    Zhu, Xiaolong; Vannahme, Christoph; Højlund-Nielsen, Emil

    2016-01-01

    -beam lithography (EBL) or focused ion beam (FIB), both expensive and not scalable processes that are not suitable for post-processing customization. Here we show a method of colour printing on nanoimprinted plasmonic metasurfaces using laser post-writing. Laser pulses induce transient local heat generation...

  10. Coupled optical resonance laser locking

    CSIR Research Space (South Africa)

    Burd, CC

    2014-10-01

    Full Text Available (11), 537–539 (1982). 16. J. F. Eble and F. Schmid-Kaler, “Optimization of frequency modulation transfer spectroscopy on the calcium 41s0 to 41p1 transition,” Appl. Phys. B 88(4), 563–568 (2007). 17. D. J. McCarron, S. A. King, and S. L. Cornish, “Modulation...

  11. Fast‐writing E‐beam for defining large arrays of nano‐holes

    DEFF Research Database (Denmark)

    Højlund-Nielsen, Emil; Clausen, Jeppe Sandvik; Christiansen, Alexander Bruun

    2013-01-01

    in [1], where electron beam lithography (EBL) with a focused Gaussian beam is used to define shapes directly. The serial technique is optimized for speed and pattern fidelity to a maximum writing speed of around 30 min/cm2 for 200 nm periods in 2D lattices. The overall costs in terms of machine time...

  12. Electron Beam Lithography of HSQ and PMMA Resists and Importance of their Properties to Link the Nano World to the Micro World

    NARCIS (Netherlands)

    Kaleli, B.; Aarnink, Antonius A.I.; Smits, Sander M.; Hueting, Raymond Josephus Engelbart; Wolters, Robertus A.M.; Schmitz, Jurriaan

    2010-01-01

    In this work we investigated the properties of HSQ and PMMA resists focusing on contrast and line width for ebeam lithography (EBL) application. HSQ was found to be a good candidate to have desired line widths but the contrast we obtained was less than it was for PMMA. Since the fluorine based

  13. An Analytical Model for the Influence of Contact Resistance on Thermoelectric Efficiency

    DEFF Research Database (Denmark)

    Bjørk, Rasmus

    2016-01-01

    as to the analytical models of Ebling et al. (J Electron Mater 39:1376, 2010) and Min and Rowe (J Power Sour 38:253, 1992). The model presented here is shown to accurately calculate the efficiency for all systems and all contact resistances considered, with an average difference in efficiency between the numerical...

  14. Numerical Investigation of InGaN Light-Emitting Diode with Al/In-Graded p-AlGaN/InGaN Superlattice Electron-Blocking Layer

    Science.gov (United States)

    Zeng, Si-Ming; Zheng, Shu-Wen; Fan, Guang-Han

    2017-02-01

    Three kinds of InGaN/GaN multiple-quantum-well light-emitting diode with different electron-blocking layers (EBLs) have been investigated numerically. The energy band diagrams, light-current curves, voltage-current curves, electrostatic fields, carrier concentrations in the quantum wells, electron current densities, radiative recombination rates in active region, and internal quantum efficiency (IQE) are reported. The results show that, when the conventional AlGaN EBL is replaced by a p-AlGaN/InGaN superlattice EBL or graded p-Al y Ga1- y N/In x Ga1- x N superlattice EBL, respectively, the light output power at 200 mA can be increased by 46.0% and 52.8%, the turn-on voltage can be decreased from 3.2 V to 3.0 V, the IQE can be increased by 45.6% and 53.8% at 200 mA, and the efficiency droop can be reduced from 31.2% to 21.6%. These improvements are mainly attributed to the properly modified energy band structures which favor carrier injection.

  15. Sub-10 nm resolution Electron Beam Lithography in ultrathin HSQ resist layers

    NARCIS (Netherlands)

    Grigorescu, A.E.

    2009-01-01

    The continuous shrinking of the feature size forces scientists and engineers to develop new lithographic techniques and suitable materials which can meet the requirements of the market. Despite its low throughput, EBL remains the number one candidate when writing very small structures. Achieving

  16. Time-Efficient High-Resolution Large-Area Nano-Patterning of Silicon Dioxide

    DEFF Research Database (Denmark)

    Lin, Li; Ou, Yiyu; Aagesen, Martin

    2017-01-01

    ) followed by a dry etching process. Afterwards, the Si stamp was employed in nanoimprint lithography (NIL) assisted with a dry etching process to produce nanoholes on the SiO2 layer. The demonstrated approach has advantages such as a high resolution in nanoscale by EBL and good reproducibility by NIL...

  17. Effect of a High-Rate Versus a Low-Rate Oxytocin Infusion for Maintaining Uterine Contractility During Elective Cesarean Delivery: A Prospective Randomized Clinical Trial.

    Science.gov (United States)

    Duffield, Adrienne; McKenzie, Christine; Carvalho, Brendan; Ramachandran, Bharathi; Yin, Victoria; El-Sayed, Yasser Y; Riley, Edward T; Butwick, Alexander J

    2017-03-01

    Oxytocin is routinely used as prophylaxis against uterine atony. During elective cesarean delivery (CD), an oxytocin bolus is used to initiate adequate uterine tone, followed by an oxytocin infusion to maintain uterine contractility. However, it is unclear whether oxytocin maintenance infusion rate influences total estimated blood loss (EBL). We performed a prospective, randomized, double-blind trial in 51 women undergoing elective CD. Women were randomly assigned to receive an oxytocin maintenance infusion of 2.5 or 15 U/h. All women received an oxytocin 1 U bolus to initiate adequate uterine tone. The primary outcome was EBL. EBL values between groups were compared using a Mann-Whitney U test; P EBL difference with 95% confidence intervals was also calculated. Secondary outcomes included adequacy of uterine tone, use of additional uterotonics, and oxytocin-related side effects, including hypotension. Of 51 women, 24 received a low-rate infusion and 27 received a high-rate infusion. Median (interquartile range) EBL values in the low-rate and high-rate groups were 634 (340-886) mL versus 512 (405-740) mL, respectively (P = .7). The median difference in EBL between groups was 22 mL; 95% confidence interval = -158 to 236 mL. The rate of postpartum hemorrhage did not differ between groups (low-rate group: 4/24 [16.7%] versus high-rate group: 4/26 [15.4%]). There were no between-group differences over time (first 20 minutes after commencing infusion) in the incidence of adequate uterine tone (P = .72) or hypotension (P = .32). Among women undergoing elective CD receiving an oxytocin maintenance infusion, EBL and uterine tone did not differ between women receiving 2.5 U/h oxytocin and those receiving 15 U/h oxytocin. Our findings suggest that efficacy can be obtained with a low oxytocin maintenance infusion rate; however, dose-finding studies are needed to determine the infusion rate that optimizes drug efficacy while minimizing side effects.

  18. Effects of 24-epibrassinolide and green light on plastid gene transcription and cytokinin content of barley leaves.

    Science.gov (United States)

    Efimova, Marina V; Vankova, Radomira; Kusnetsov, Victor V; Litvinovskaya, Raisa P; Zlobin, Ilya E; Dobrev, Petre; Vedenicheva, Nina P; Savchuk, Alina L; Karnachuk, Raisa A; Kudryakova, Natalia V; Kuznetsov, Vladimir V

    2017-04-01

    In order to evaluate whether brassinosteroids (BS) and green light regulate the transcription of plastid genes in a cross-talk with cytokinins (CKs), transcription rates of 12 plastid genes (ndhF, rrn23, rpoB, psaA, psaB, rrn16, psbA, psbD, psbK, rbcL, atpB, and trnE/trnY) as well as the accumulation of transcripts of some photoreceptors (PHYA, CRY2, CRY1A, and CRY1B) and signaling (SERK and CAS) genes were followed in detached etiolated barley leaves exposed to darkness, green or white light ±1μm 24-epibrassinolide (EBL). EBL in the dark was shown to up-regulate the transcription of 12 plastid genes, while green light activated 10 genes and the EBL combined with the green light affected the transcription of only two genes (psaB and rpoB). Green light inhibited the expression of photoreceptor genes, except for CRY1A. Under the green light, EBL practically did not affect the expression of CRY1A, CAS and SERK genes, but it reduced the influence of white light on the accumulation of CAS, CRY1A, CRY1B, and SERK gene transcripts. The total content of BS in the dark and under white light remained largely unchanged, while under green light the total content of BRs (brassinolide, castasterone, and 6-deoxocastasterone) and HBRs (28-homobrassinolide, 28-homocastasterone, and 6-deoxo-28-homocastasterone) increased. The EBL-dependent up-regulation of plastome transcription in the dark was accompanied by a significant decrease in CK deactivation by O-glucosylation. However, no significant effect on the content of active CKs was detected. EBL combined with green light moderately increased the contents of trans-zeatin and isopentenyladenine, but had a negative effect on cis-zeatin. The most significant promotive effect of EBL on active CK bases was observed in white light. The data obtained suggest the involvement of CKs in the BS- and light-dependent transcription regulation of plastid genes. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Intensity Mapping of the History of Stellar Emission with the Cosmic Infrared Background ExpeRiment-2

    Science.gov (United States)

    Lanz, Alicia E.; Arai, Toshiaki; Battle, John; Bock, James; Cooray, Asantha R.; Hristov, Viktor; Korngut, Phillip; Lee, Dae Hee; Mason, Peter; Matsumoto, Toshio; Matsuura, Shuji; Onishi, Yosuke; Shirahata, Mai; Tsumurai, Kohji; Wada, Takehiko; Zemcov, Michael B.

    2016-01-01

    Recent measurements of the near-infrared Extragalactic Background Light (EBL) anisotropy find excess spatial power above the level predicted by known galaxy populations at large angular scales. These anisotropies trace spatial variations in integrated photon production, so measurements of EBL surface brightness fluctuations provide a complete census of the emission from stars summed over cosmic history. As a result, EBL fluctuations contain contributions from objects forming during the Epoch of Reionization (EOR), from the integrated galactic light (IGL), and faint, extended components such as intra-halo light (IHL) from stars tidally stripped from galaxies during merger events. Additional measurements with greater sensitivity, spectral range, and spectral resolution are required to disentangle these contributions.The Cosmic Infrared Background ExpeRiment 2 (CIBER-2) is an instrument optimized for the measurement of near-infrared EBL anisotropies. As the Earth's atmosphere generates time-varying near-infrared emission, CIBER-2 is launched on a sounding rocket from which it will carry out multiwavelength imaging in six spectral bands that span the visible to near-infrared. The 2.4 square degree images allow CIBER-2 to produce measurements of EBL fluctuations with high fidelity on large angular scales. The Lyman break feature from EOR sources provides a unique spectral feature which can be used to disentangle the high from the low redshift contributions to the anisotropy signal. Measurement in six independent wavebands allows detailed cross-correlation studies to constrain the source of the excess fluctuations at large angular scales. We provide an overview of the CIBER-2 instrument and explain CIBER-2 spectral feature identification and cross-correlation study methodologies.

  20. Near-IR Extragalactic Background Results from the Cosmic Infrared Background Experiment (CIBER)

    Science.gov (United States)

    Zemcov, Michael B.; CIBER

    2016-01-01

    The near IR extragalactic background light (EBL) encodes the integrated light production over cosmic history, so represents the total emission from all galaxies along the line of sight up to ancient first-light objects present during the epoch of reionization (EOR). This EOR emission necessarily comprises part of the background, and indeed a minimum level is required to supply enough photons to ionize the intergalactic medium, corresponding to an EBL brightness less than 1 nW m^-2 sr^-1, about one tenth of the integrated galactic light (IGL). In addition to emission from these IGL and EOR populations, low surface brightness tidal streams of stars stripped by gravitational interactions during galaxy formation at low redshifts, called intrahalo light (IHL), may also contribute a significant fraction of the EBL. Models for these components can be constrained both through direct photometric measurements, as well as the new technique of EBL anisotropy intensity mapping that takes advantage of the fact that the Zodiacal Light is spatially smooth while distant populations produce anisotropies with distinct spatial and spectral characteristics. This talk will present recent results from the Cosmic Infrared Background Experiment (CIBER), a sounding rocket borne payload designed to measure both the fluctuations and direct photometric emission of the extra-galactic background light. The anisotropy of the near-IR EBL suggests the presence of a bright component approximately as bright as the IGL component near 1 micron which we interpret as the aggregate emission from low-redshift IHL. New direct photometric measurements from CIBER's low resolution spectrometer will also be discussed.

  1. Test of models of the cosmic infrared background with multiwavelength observations of the blazar 1ES 1218+30.4 in 2009

    Energy Technology Data Exchange (ETDEWEB)

    Archambault, S. [Physics Department, McGill University, Montreal, QC H3A 2T8 (Canada); Arlen, T.; Aune, T. [Department of Physics and Astronomy, University of California, Los Angeles, CA 90095 (United States); Beilicke, M.; Buckley, J. H.; Bugaev, V.; Dickherber, R. [Department of Physics, Washington University, St. Louis, MO 63130 (United States); Benbow, W. [Fred Lawrence Whipple Observatory, Harvard-Smithsonian Center for Astrophysics, Amado, AZ 85645 (United States); Bird, R.; Collins-Hughes, E. [School of Physics, University College Dublin, Belfield, Dublin 4 (Ireland); Böttcher, M. [Department of Physics and Astronomy, Ohio University, Clippinger 339, Athens, OH 45701-2979 (United States); Bouvier, A. [Santa Cruz Institute for Particle Physics and Department of Physics, University of California, Santa Cruz, CA 95064 (United States); Ciupik, L. [Astronomy Department, Adler Planetarium and Astronomy Museum, Chicago, IL 60605 (United States); Connolly, M. P. [School of Physics, National University of Ireland Galway, University Road, Galway (Ireland); Cui, W.; Feng, Q. [Department of Physics, Purdue University, West Lafayette, IN 47907 (United States); Dumm, J. [School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455 (United States); Errando, M. [Department of Physics and Astronomy, Barnard College, Columbia University, New York, NY 10027 (United States); Falcone, A. [Department of Astronomy and Astrophysics, Pennsylvania State University, 525 Davey Lab, University Park, PA 16802 (United States); Federici, S., E-mail: krawcz@wuphys.wustl.edu [DESY, Platanenallee 6, D-15738 Zeuthen (Germany); and others

    2014-06-20

    We present the results of a multi-wavelength campaign targeting the blazar 1ES 1218+30.4 with observations with the 1.3 m McGraw-Hill optical telescope, the Rossi X-ray Timing Explorer (RXTE), the Fermi Gamma-Ray Space Telescope, and the Very Energetic Radiation Imaging Telescope Array System (VERITAS). The RXTE and VERITAS observations were spread over a 13 day period and revealed clear evidence for flux variability, and a strong X-ray and γ-ray flare on 2009 February 26 (MJD 54888). The campaign delivered a well-sampled broadband energy spectrum with simultaneous RXTE and VERITAS very high energy (VHE, >100 GeV) observations, as well as contemporaneous optical and Fermi observations. The 1ES 1218+30.4 broadband energy spectrum—the first with simultaneous X-ray and VHE γ-ray energy spectra—is of particular interest as the source is located at a high cosmological redshift for a VHE source (z = 0.182), leading to strong absorption of VHE gamma rays by photons from the optical/infrared extragalactic background light (EBL) via γ{sub VHE} + γ{sub EBL} → e {sup +} e {sup –} pair-creation processes. We model the data with a one-zone synchrotron self-Compton (SSC) emission model and with the extragalactic absorption predicted by several recent EBL models. We find that the observations are consistent with the SSC scenario and all the EBL models considered in this work. We discuss observational and theoretical avenues to improve on the EBL constraints.

  2. Effect of exogenous H2O2 on antioxidant enzymes of Brassica juncea L. seedlings in relation to 24-epibrassinolide under chilling stress.

    Science.gov (United States)

    Kumar, Manish; Sirhindi, Geetika; Bhardwaj, Renu; Kumar, Sandeep; Jain, Gagandeep

    2010-12-01

    Hydrogen peroxide is most stable molecule among reactive oxygen species, which play a vital role in growth and development of plant as signaling molecule at low concentration in response to various abiotic and biotic stresses. Exogenous application of H2O2 is known to induce chilling tolerance in plants. Brassinosteroids are plant steroid hormones known for their anti-stress properties. In this study, effect of exogenous H2O2 on antioxidant defense system of Brassica juncea L. seedlings was investigated in 24-epibrassinolide (24-EBL) treated and untreated seedlings under chilling stress. The surface sterilized seeds of B. juncea L. were germinated in petriplates containing different concentrations of H2O2 alone and in combination with 10(-8) M 24-EBL. Chilling treatment (4 degrees C) was given to 10-days old seedlings grown in different treatments for 6 h daily up to 3 days. 24 h recovery period was given to chilling treated seedlings by placing at 25 degrees C + 2 degrees C and harvested for antioxidant enzymes on 14th day after sowing (DAS). Treatment of 24-EBL in combination with H2O2 (15 and 20 mM) helped in reducing the toxicity of seed and seedlings due to H2O2 exposure on their germination rate, shoot and root length respectively. 24-EBL treatment at seed and seedling stage helped in alleviating the toxic effect of H2O2 through antioxidant defense system by increasing the activities of various enzymes involved in antioxidant defense system such as catalase (CAT, E.C. 1.11.1.6), ascorbate peroxidase (APOX, E.C. 1.11.1.11), and superoxide dismutase (SOD, E.C. 1.15.1.1). In conclusion, exogenous pretreatment of H2O2 to seeds of B. juncea L. adapted the seedlings to tolerate chilling stress, which was further ameliorated in combination of H2O2 with 24-EBL.

  3. Novel application of pre-operative vertebral body embolization to reduce intraoperative blood loss during a three-column spinal osteotomy for non-oncologic spinal deformity.

    Science.gov (United States)

    Tuchman, Alexander; Mehta, Vivek A; Mack, William J; Acosta, Frank L

    2015-04-01

    Three column osteotomies (3CO) of the lumbar spine are powerful corrective procedures used in the treatment of kyphoscoliosis. Their efficacy comes at the cost of high reported complication rates, notably significant estimated blood loss (EBL). Previously reported techniques to reduce EBL have had modest efficacy. Here we describe a potential technique to decrease EBL during pedicle subtraction osteotomy (PSO) of the lumbar spine by means of pre-operative vertebral body embolization - a technique traditionally used to reduce blood loss prior to spinal column tumor resection. We present a 62-year-old man with iatrogenic kyphoscoliosis who underwent staged deformity correction. Stage 1 involved thoracolumbar instrumentation followed by transarterial embolization of the L4 vertebral body through bilateral segmental arteries. A combination of polyvinyl alcohol particles and Gelfoam (Pfizer, New York, NY, USA) were used. Following embolization there was decreased angiographic blood flow to the small vessels of the L4 vertebral body, while the segmental arteries remained patent. Stage 2 consisted of an L4 PSO and fusion. The EBL during the PSO procedure was 1L, which compared favorably to that during previous PSO at this institution as well as to quantities reported in previous literature. There have been no short term (5 month follow-up) complications attributable to the vertebral body embolization or surgical procedure. Although further investigation into this technique is required to better characterize its safety and efficacy in reducing EBL during 3CO, we believe this patient illustrates the potential utility of pre-operative vertebral embolization in the setting of non-oncologic deformity correction surgery.

  4. Contribution of the first galaxies to the cosmic far-infrared/sub-millimeter background - I. Mean background level

    Science.gov (United States)

    De Rossi, María Emilia; Bromm, Volker

    2017-03-01

    We study the contribution of the first galaxies to the far-infrared/sub-millimeter (FIR/sub-mm) extragalactic background light (EBL) by implementing an analytical model for dust emission. We explore different dust models, assuming different grain-size distributions and chemical compositions. According to our findings, observed reradiated emission from dust in dwarf-size galaxies at z ∼ 10 would peak at a wavelength of ∼ 500 μm with observed fluxes of ∼10-3-10-2 nJy, which is below the capabilities of current observatories. In order to be detectable, model sources at these high redshifts should exhibit luminosities of ≳1012 L⊙, comparable to that of local ultraluminous systems. The FIR/sub-mm-EBL generated by primeval galaxies peaks at ∼ 500 μm, with an intensity ranging from ∼10-4 to 10-3 nW m-2 sr-1, depending on dust properties. These values are ∼3-4 orders of magnitude below the absolute measured cosmic background level, suggesting that the first galaxies would not contribute significantly to the observed FIR/sub-mm-EBL. Our model EBL exhibits a strong correlation with the dust-to-metal ratio, where we assume a fiducial value of D = 0.005, increasing almost proportionally to it. Thus, measurements of the FIR/sub-mm-EBL could provide constraints on the amount of dust in the early Universe. Even if the absolute signal from primeval dust emission may be undetectable, it might still be possible to obtain information about it by exploring angular fluctuations at ∼ 500 μm, close to the peak of dust emission from the first galaxies.

  5. Extragalactic background light: a measurement at 400 nm using dark cloud shadow - II. Spectroscopic separation of the dark cloud's light, and results★

    Science.gov (United States)

    Mattila, K.; Väisänen, P.; Lehtinen, K.; von Appen-Schnur, G.; Leinert, Ch.

    2017-09-01

    In a project aimed at measuring the optical extragalactic background light (EBL), we are using the shadow of a dark cloud. We have performed, with the ESO VLT/FORS, spectrophotometry of the surface brightness towards the high-galactic-latitude dark cloud Lynds 1642. A spectrum representing the difference between the opaque core of the cloud and several unobscured positions around the cloud was presented in Paper I. The topic of this paper is the separation of the scattered starlight from the dark cloud itself which is the only remaining foreground component in this difference. While the scattered starlight spectrum has the characteristic Fraunhofer lines and the discontinuity at 400 nm, typical of integrated light of galaxies, the EBL spectrum is a smooth one without these features. As template for the scattered starlight, we make use of the spectra at two semitransparent positions. The resulting EBL intensity at 400 nm is IEBL = 2.9 ± 1.1 10-9 erg cm-2 s-1 sr-1 Å-1 or 11.6 ± 4.4 nW m-2sr-1, which represents a 2.6σ detection; the scaling uncertainty is +20 per cent/-16 per cent. At 520 nm, we have set a 2σ upper limit of IEBL ≤4.5 10-9 erg cm-2 s-1 sr-1 Å-1 or ≤ 23.4 nW m-2sr-1 +20 per cent/-16 per cent. Our EBL value at 400 nm is ≳ 2 times as high as the integrated light of galaxies. No known diffuse light sources, such as light from Milky Way halo, intra-cluster or intra-group stars appear capable of explaining the observed EBL excess over the integrated light of galaxies.

  6. Yearbook 2008; Jahrbuch 2008

    Energy Technology Data Exchange (ETDEWEB)

    Brandi-Dohrn, Anselm; Heckmann, Dirk (eds.)

    2009-07-01

    The yearbook 2008 of information technology and law contains the following contributions: (a) Does the data protection need a new fundamental right? (Wolfgang Hoffmann-Riem); (b) Energy efficiency needs IKT. IKT needs energy efficiency (Michael Zinke, Ludwig Karg); (c) IBM: Green Responsibility - an energy model and environment model for companies (Klaus-Juergen Ruenger); (d) Monetary pitfalls in the internet: Development and court decisions in the years 2007 and 2008 (Thomas Bradler); (e) Information of withdrawal in remote distribution (Mathias Lejeune); (f) Report on the workshop 'ITIL processes at IT projects (IT - infrastructure library)' (Thomas H. Fischer); (g) Report on the workshop 'Data protection as a entrepreneurial risk?' (Dirk Heckmann); (h) Report on the workshop 'Actual questions of properties rights (Oliver Meyer-van Raay); (i) The suitable claims of damages at the violation of intellectual property (Ulrike Gedert); (j) Consequences of regulation for the implementation of the rights of intellectual property on the German civil procedure law (Susanne Klein); (k) A data protective evaluation and rights of concerned people in the credit investigation in Greek under consideration of the European and German law (Timoleon Kosmides); (l) Mediator between the worlds: Prof. Dr. jur. Dr. rer. Nat. Herbert Fiedler in portrait (Dirk Heckmann).

  7. Homo naledi and Pleistocene hominin evolution in subequatorial Africa

    Science.gov (United States)

    Berger, Lee R; Hawks, John; Dirks, Paul HGM; Elliott, Marina; Roberts, Eric M

    2017-01-01

    New discoveries and dating of fossil remains from the Rising Star cave system, Cradle of Humankind, South Africa, have strong implications for our understanding of Pleistocene human evolution in Africa. Direct dating of Homo naledi fossils from the Dinaledi Chamber (Berger et al., 2015) shows that they were deposited between about 236 ka and 335 ka (Dirks et al., 2017), placing H. naledi in the later Middle Pleistocene. Hawks and colleagues (Hawks et al., 2017) report the discovery of a second chamber within the Rising Star system (Dirks et al., 2015) that contains H. naledi remains. Previously, only large-brained modern humans or their close relatives had been demonstrated to exist at this late time in Africa, but the fossil evidence for any hominins in subequatorial Africa was very sparse. It is now evident that a diversity of hominin lineages existed in this region, with some divergent lineages contributing DNA to living humans and at least H. naledi representing a survivor from the earliest stages of diversification within Homo. The existence of a diverse array of hominins in subequatorial comports with our present knowledge of diversity across other savanna-adapted species, as well as with palaeoclimate and paleoenvironmental data. H. naledi casts the fossil and archaeological records into a new light, as we cannot exclude that this lineage was responsible for the production of Acheulean or Middle Stone Age tool industries. DOI: http://dx.doi.org/10.7554/eLife.24234.001 PMID:28483041

  8. Endoscopic band ligation versus pharmacological therapy for variceal bleeding in cirrhosis: a meta-analysis.

    Science.gov (United States)

    Li, Lan; Yu, Chaohui; Li, Youming

    2011-03-01

    To conduct a meta-analysis of published, full-length, randomized controlled trials evaluating the efficacy of endoscopic band ligation (EBL) versus pharmacological therapy for the primary and secondary prophylaxis of variceal hemorrhage in patients with cirrhosis. Literature searches were conducted using the PubMed, EMBASE and Cochrane Library databases. Eighteen randomized clinical trials that fulfilled the inclusion criteria were further pooled into a meta-analysis. Among 1023 patients in 12 trials comparing EBL with beta-blockers for primary prevention, there was no significant difference in gastrointestinal bleeding (RR 0.79 [95% CI 0.61 to 1.02]), all-cause deaths (RR 1.06 [95% CI 0.86 to 1.30]) or bleeding-related deaths (RR 0.66 [95% CI 0.38 to 1.16]). There was a reduced trend toward significance in variceal bleeding with EBL compared with betablockers (RR 0.72 [95% CI 0.54 to 0.96]). However, variceal bleeding was not significantly different between the two groups in high-quality trials (RR 0.84 [95% CI 0.60 to 1.17]). Among 687 patients from six trials comparing EBL with beta-blockers plus isosorbide mononitrate for secondary prevention, there was no effect on either gastrointestinal bleeding (RR 0.95 [95% CI 0.65 to 1.40]) or variceal bleeding (RR 0.89 [95% CI 0.53 to 1.49]). The risk for all-cause deaths in the EBL group was significantly higher than in the medical group (RR 1.25 [95% CI 1.01 to 1.55]); however, the rate of bleeding related deaths was unaffected (RR 1.16 [95% CI 0.68 to 1.97]). Both EBL and beta-blockers may be considered first-line treatments to prevent first variceal bleeding, whereas betablockers plus isosorbide mononitrate may be the best choice for the prevention of rebleeding.

  9. Human and Epstein-Barr Virus miRNA Profiling as Predictive Biomarkers for Endemic Burkitt Lymphoma.

    Science.gov (United States)

    Oduor, Cliff I; Movassagh, Mercedeh; Kaymaz, Yasin; Chelimo, Kiprotich; Otieno, Juliana; Ong'echa, John M; Moormann, Ann M; Bailey, Jeffrey A

    2017-01-01

    Endemic Burkitt lymphoma (eBL) is an aggressive B cell lymphoma and is associated with Epstein-Barr virus (EBV) and Plasmodium falciparum malaria co-infections. Central to BL oncogenesis is the over-expression of the MYC proto-oncogene which is caused by a translocation of an Ig enhancer in approximation to the myc gene. While whole genome/transcriptome sequencing methods have been used to define driver mutations and transcriptional dysregulation, microRNA (miRNA) dysregulation and differential expression has yet to be fully characterized. We hypothesized that both human and EBV miRNAs contribute to eBL clinical presentation, disease progression, and poor outcomes. Using sensitive and precise deep sequencing, we identified miRNAs from 17 Kenyan eBL patient tumor samples and delineated the complement of both host and EBV miRNAs. One human miRNA, hsa-miR-10a-5p was found to be differentially expressed (DE), being down-regulated in jaw tumors relative to abdominal and in non-survivors compared to survivors. We also examined EBV miRNAs, which made up 2.7% of the miRNA composition in the eBL samples. However, we did not find any significant associations regarding initial patient outcome or anatomical presentation. Gene ontology analysis and pathway enrichment of previously validated targets of miR-10a-5p suggest that it can promote tumor cell survival as well as aid in evasion of apoptosis. To examine miR-10a-5p regulatory effect on gene expression in eBL, we performed a pairwise correlation coefficient analysis on the expression levels of all its validated targets. We found a significant enrichment of correlated target genes consistent with miR-10a-5p impacting expression. The functions of genes and their correlation fit with multiple target genes impacting tumor resilience. The observed downregulation of miR-10a and associated genes suggests a role for miRNA in eBL patient outcomes and has potential as a predictive biomarker that warrants further investigation.

  10. Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type-Specific Differences.

    Science.gov (United States)

    Kaymaz, Yasin; Oduor, Cliff I; Yu, Hongbo; Otieno, Juliana A; Ong'echa, John Michael; Moormann, Ann M; Bailey, Jeffrey A

    2017-05-01

    Endemic Burkitt lymphoma (eBL) is the most common pediatric cancer in malaria-endemic equatorial Africa and nearly always contains Epstein-Barr virus (EBV), unlike sporadic Burkitt lymphoma (sBL) that occurs with a lower incidence in developed countries. Given these differences and the variable clinical presentation and outcomes, we sought to further understand pathogenesis by investigating transcriptomes using RNA sequencing (RNAseq) from multiple primary eBL tumors compared with sBL tumors. Within eBL tumors, minimal expression differences were found based on: anatomical presentation site, in-hospital survival rates, and EBV genome type, suggesting that eBL tumors are homogeneous without marked subtypes. The outstanding difference detected using surrogate variable analysis was the significantly decreased expression of key genes in the immunoproteasome complex (PSMB9/β1i, PSMB10/β2i, PSMB8/β5i, and PSME2/PA28β) in eBL tumors carrying type 2 EBV compared with type 1 EBV. Second, in comparison with previously published pediatric sBL specimens, the majority of the expression and pathway differences was related to the PTEN/PI3K/mTOR signaling pathway and was correlated most strongly with EBV status rather than geographic designation. Third, common mutations were observed significantly less frequently in eBL tumors harboring EBV type 1, with mutation frequencies similar between tumors with EBV type 2 and without EBV. In addition to the previously reported genes, a set of new genes mutated in BL, including TFAP4, MSH6, PRRC2C, BCL7A, FOXO1, PLCG2, PRKDC, RAD50, and RPRD2, were identified. Overall, these data establish that EBV, particularly EBV type 1, supports BL oncogenesis, alleviating the need for certain driver mutations in the human genome. Genomic and mutational analyses of Burkitt lymphoma tumors identify key differences based on viral content and clinical outcomes suggesting new avenues for the development of prognostic molecular biomarkers and therapeutic

  11. A WISE Measurement of the 2:4 mum Galaxy Luminosity Function and its Implications for the Extragalactic Background Light at 3:4 mum

    Science.gov (United States)

    Lake, Sean Earl

    2017-05-01

    The measurement of the the Extragalactic Background Light (EBL) has seen some controversy in recent works, with direct and indirect measures conflicting. Specifi- cally, upper limits based on analyzing the plausible opacity obscuring TeV spectra of blazars suggests that the density of radiation with wavelengths near 3.4 mum is onethirdtoonehalfasintenseasdirectmeasuresofthesame(forexample: Aharonian et al., 2006; Levenson et al., 2007; Matsumoto et al., 2005). The dominant contributor of the EBL at 3.4mum is expected to be ordinary starlight from relatively local, z EBL. While analyses of this sort have been done by others (Dominguez et al., 2011; Helgason et al., 2012), the full sky coverage of the AllWISE database has made it possible for us to improve the measurement of both the LF at 2.4 mum and the EBL using the large public spectroscopic redshift surveys. In order to do so, we had to develop a mathematical model for the measurement of a generalization of the LF, which is the density of galaxies per unit comoving volume per unit luminosity, to the Spectro-Luminosity Functional (SLF), which replaces the density per unit single luminosity, dL, with the density per luminosi- ii ties at all frequencies, DL nu. Our best combined analysis of the data yields present day Shechter Function LF parameters of: L⋆ = 6.4+/-[0.1 stat, 0.3sys]x1010 L2.4mum [solar mass](M⋆ = -21.67+/-[0.02 stat, 0.05sys] AB mag), φ⋆ = 5.8+/-[0.3stat, 0.3sys]x10 -3 Mpc-3, and alpha = -1.050 +/- [0.004stat, 0.03sys]; this implies a present day density of galaxies of 0.08 Mpc-3 brighter that 106 L2.4mum [solar mass] (10-3 Mpc-3 brighter than L⋆) and a luminosity density equivalent to 3.8 x 108 L2.4mum [solar mass] Mpc-3. The net EBL at 3.4mum that our synthesis model produces from galaxies closer than z = 5 is Inu = 9.0 +/- 0.5 kJy sr-1 (nuInu = 8.0 +/- 0.4 nW m-2 sr -1), largely in agreement with similar LF based estimates of the EBL.

  12. Flat metallic surface gratings with sub-10 nm gaps controlled by atomic-layer deposition

    Science.gov (United States)

    Chen, Borui; Ji, Dengxin; Cheney, Alec; Zhang, Nan; Song, Haomin; Zeng, Xie; Thomay, Tim; Gan, Qiaoqiang; Cartwright, Alexander

    2016-09-01

    Atomic layer lithography is a recently reported new technology to fabricate deep-subwavelength features down to 1-2 nm, based on combinations of electron beam lithography (EBL) and atomic layer deposition (ALD). However, the patterning area is relatively small as limited by EBL, and the fabrication yield is not very high due to technical challenges. Here we report an improved procedure to fabricate flat metallic surfaces with sub-10 nm features based on ALD processes. To demonstrate the scalability of the new manufacturing method, we combine the ALD process with large area optical interference patterning, which is particularly promising for the development of practical applications for nanoelectronics and nanophotonics with extremely strong confinement of electromagnetic fields.

  13. Strategically aligning a mandala of competencies to advance a transformative vision.

    Science.gov (United States)

    Giuse, Nunzia B; Kusnoor, Sheila V; Koonce, Taneya Y; Ryland, Christopher R; Walden, Rachel R; Naylor, Helen M; Williams, Annette M; Jerome, Rebecca N

    2013-10-01

    This paper offers insight into the processes that have shaped the Eskind Biomedical Library's (EBL's) strategic direction and its alignment to the institution's transformative vision. The academic biomedical library has a notable track record for developing and pioneering roles for information professionals focused on a sophisticated level of information provision that draws from and fuels practice evolutions. The medical center's overall transformative vision informs the creation of a fully aligned library strategic plan designed to effectively contribute to the execution of key organizational goals. Annual goals reflect organizational priorities and contain quantifiable and measurable deliverables. Two strategic themes, facilitating genetic literacy and preserving community history, are described in detail to illustrate the concept of goal setting. The strategic planning model reflects EBL's adaptation to the ever-changing needs of its organization. The paper provides a characterization of a workable model that can be replicated by other institutions.

  14. From scientifically based research to evidence based learning

    Directory of Open Access Journals (Sweden)

    Rosa Cera

    2016-02-01

    Full Text Available This essay is a reflection on the peculiarities of the scientifically based research and on the distinctive elements of the EBL (evidence based learning, methodology used in the study on the “Relationship between Metacognition, Self-efficacy and Self-regulation in Learning”. The EBL method, based on the standardization of data, explains how the students’ learning experience can be considered as a set of “data” and can be used to explain how and when the research results can be considered generalizable and transferable to other learning situations. The reflections present in this study have also allowed us to illustrate the impact that its results have had on the micro and macro level of reality. They helped to fill in the gaps concerning the learning/teaching processes, contributed to the enrichment of the scientific literature on this subject and allowed to establish standards through rigorous techniques such as systematic reviews and meta-analysis.

  15. Polystyrene negative resist for high-resolution electron beam lithography

    Directory of Open Access Journals (Sweden)

    Ma Siqi

    2011-01-01

    Full Text Available Abstract We studied the exposure behavior of low molecular weight polystyrene as a negative tone electron beam lithography (EBL resist, with the goal of finding the ultimate achievable resolution. It demonstrated fairly well-defined patterning of a 20-nm period line array and a 15-nm period dot array, which are the densest patterns ever achieved using organic EBL resists. Such dense patterns can be achieved both at 20 and 5 keV beam energies using different developers. In addition to its ultra-high resolution capability, polystyrene is a simple and low-cost resist with easy process control and practically unlimited shelf life. It is also considerably more resistant to dry etching than PMMA. With a low sensitivity, it would find applications where negative resist is desired and throughput is not a major concern.

  16. Probing the very-high-energy gamma-ray spectral curvature in the blazar PG 1553+113 with the MAGIC telescopes

    CERN Document Server

    Aleksić, J.; Antonelli, L A; Antoranz, P; Babic, A; Bangale, P; Barrio, J A; González, J Becerra; Bednarek, W; Bernardini, E; Biasuzzi, B; Biland, A; Blanch, O; Bonnefoy, S; Bonnoli, G; Borracci, F; Bretz, T; Carmona, E; Carosi, A; Colin, P; Colombo, E; Contreras, J.L; Cortina, J; Covino, S; Da Vela, P; Dazzi, F; De Angelis, A; De Caneva, G; De Lotto, B; Wilhelmi, E de Oña; Mendez, C Delgado; Prester, D Dominis; Dorner, D; Doro, M; Einecke, S; Eisenacher, D; Elsaesser, D; Fidalgo, D; Fonseca, M.V; Font, L; Frantzen, K; Fruck, C; Galindo, D; López, R J García; Garczarczyk, M; Terrats, D Garrido; Gaug, M; Godinović, N; Muñoz, A González; Gozzini, S R; Hadasch, D; Hanabata, Y; Hayashida, M; Herrera, J; Hose, J; Hrupec, D; Idec, W; Kadenius, V; Kellermann, H; Knoetig, M L; Kodani, K; Konno, Y; Krause, J; Kubo, H; Kushida, J; La Barbera, A; Lelas, D; Lewandowska, N; Lindfors, E; Lombardi, S; Longo, F; López, M; López-Coto, R; López-Oramas, A; Lorenz, E; Lozano, I; Makariev, M; Mallot, K; Maneva, G; Mannheim, K; Maraschi, L; Marcote, B; Mariotti, M; Martínez, M; Mazin, D; Menzel, U; Miranda, J M; Mirzoyan, R; Moralejo, A; Munar-Adrover, P; Nakajima, D; Neustroev, V; Niedzwiecki, A; Nilsson, K; Nishijima, K; Noda, K; Orito, R; Overkemping, A; Paiano, S; Palatiello, M; Paneque, D; Paoletti, R; Paredes, J M; Paredes-Fortuny, X; Persic, M; Poutanen, J; Moroni, P G Prada; Prandini, E; Puljak, I; Reinthal, R; Rhode, W; Ribó, M; Rico, J; Garcia, J Rodriguez; Rügamer, S; Saito, T; Saito, K; Satalecka, K; Scalzotto, V; Scapin, V; Schultz, C; Schweizer, T; Sillanpää, A; Sitarek, J; Snidaric, I; Sobczynska, D; Spanier, F; Stamerra, A; Steinbring, T; Storz, J; Strzys, M; Takalo, L; Takami, H; Tavecchio, F; Temnikov, P; Terzić, T; Tescaro, D; Teshima, M; Thaele, J; Tibolla, O; Torres, D F; Toyama, T; Treves, A; Vogler, P; Will, M; Zanin, R; D'Ammando, F; Lähteenmäki, A; Tornikoski, M; Hovatta, T; Readhead, A C S; Max-Moerbeck, W; Richards, J.L

    2015-01-01

    PG 1553+113 is a very-high-energy (VHE, E>100 GeV) gamma-ray emitter classified as a BL Lac object. Its redshift is constrained by intergalactic absorption lines in the range 0.40.2). The observed curvature is compatible with the extragalactic background light (EBL) imprint predicted by the current generation of EBL models assuming a redshift z~0.4. New constraints on the redshift were derived from the VHE spectrum. These constraints are compatible with previous limits and suggest that the source is most likely located around the optical lower limit, z=0.4. Finally, we find that the synchrotron self-Compton (SSC) model gives a satisfactory description of the observed multi-wavelength spectral energy distribution during the flare.

  17. Novel Route to Fabrication of Metal-Sandwiched Nanoscale Tapered Structures

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yang; YU Da-Peng

    2009-01-01

    Tapered dielectric structures in metal have exhibited extraordinary performance in both surface plasmon polariton (SPP) waveguiding and SPP focusing.This is crucial to plazmonic research and industrial plasmonic device integration.We present a method that facilitates easy fabrication of smooth-surfaced sub-micron tapered structures in large scale simply with electron beam lithography (EBL).When a PMMA layer is spin-coated on previously-EBL-defined PMMA structures,steep edges can be transformed into a declining slope to form tapered PMMA structures,scaled from 10nm to 1000nm.Despite the simplicity of our method,patterns with PMMA surface smoothness can be well-positioned and replicated in large numbers,which therefore gives scientists easy access to research on the properties of tapered structures.

  18. Enhanced carrier injection in InGaN/GaN multiple quantum wells LED with polarization-induced electron blocking barrier

    Science.gov (United States)

    Li, Chengguo; Liu, Hongfei; Chua, Soo Jin

    2016-03-01

    In this report, we designed a light emitting diode (LED) structure in which an N-polar p-GaN layer is grown on top of Ga-polar In0.1Ga0.9N/GaN quantum wells (QWs) on an n-GaN layer. Numerical simulation reveals that the large polarization field at the polarity inversion interface induces a potential barrier in the conduction band, which can block electron overflow out of the QWs. Compared with a conventional LED structure with an Al0.2Ga0.8N electron blocking layer (EBL), the proposed LED structure shows much lower electron current leakage, higher hole injection, and a significant improvement in the internal quantum efficiency (IQE). These results suggest that the polarization induced barrier (PIB) is more effective than the AlGaN EBL in suppressing electron overflow and improving hole transport in GaN-based LEDs.

  19. Effects of uncertainties in simulations of extragalactic UHECR propagation, using CRPropa and SimProp

    CERN Document Server

    Batista, Rafael Alves; di Matteo, Armando; van Vliet, Arjen; Walz, David

    2015-01-01

    The results of simulations of the extragalactic propagation of ultra-high energy cosmic rays (UHECRs) have intrinsic uncertainties due to poorly known physical quantities and approximations used in the codes. We quantify the uncertainties in the simulated UHECR spectrum and composition due to different models for the extragalactic background light (EBL), different photodisintegration setups, approximations concerning photopion production and the use of different simulation codes. We discuss the results for several representative source scenarios with proton, nitrogen or iron at injection. For this purpose we used SimProp and CRPropa, two publicly available codes for Monte Carlo simulations of UHECR propagation. CRPropa is a detailed and extensive simulation code, while SimProp aims to achieve acceptable results using a simpler code. We show that especially the choices for the EBL model and the photodisintegration setup can have a considerable impact on the simulated UHECR spectrum and composition.

  20. Reconstructive pelvic surgery and plastic surgery: safety and efficacy of combined surgery.

    Science.gov (United States)

    Craig, Jocelyn B; Noblett, Karen L; Conner, Caroline A; Budd, Michael; Lane, Felicia L

    2008-12-01

    The purpose of this study was to address the safety of combining aesthetic and pelvic floor reconstructive procedures. Fifty-four subjects were included in a case-control study; 18 patients undergoing combined pelvic and plastic reconstructive surgery, age and procedure matched to 18 pelvic surgery and 18 plastic surgery only controls. Chi-square, t test, and Kruskal-Wallis analysis were used to compare the estimated blood loss (EBL), body mass index (BMI), hospital days, operative times, and complications between the groups. No differences were seen with regards to age, BMI, or EBL. There was, however, a significant increase in minor complications and hospital stay after combined procedures relative to the pelvic surgery control group but not the aesthetic control group. Operative times were only greater during combined procedures relative to isolated pelvic floor procedures. Combining pelvic and aesthetic procedures may increase complications, operative times, and length of hospital stay when compared to pelvic reconstructive surgery alone.

  1. Detecting extended gamma-ray emission with the next generation Cherenkov telescopes

    CERN Document Server

    Alonso, M Fernandez; Rovero, A C

    2015-01-01

    Very high energy (VHE $>$100 GeV) gamma rays coming from blazars can produce pairs when interacting with the Extragalactic Background Light (EBL) and the Cosmic Microwave Background, generating an electromagnetic cascade. Depending on the Intergalactic Magnetic Field (IGMF) intensity, this cascade may result in an extended isotropic emission of photons around the source (halo), or in a broadening of the emission beam. The detection of these effects might lead to important constrains both on the IGMF intensity and the EBL density, quantities of great relevance in cosmological models. Using a Monte Carlo program, we simulate electromagnetic cascades for different values of the IGMF intensities and coming from a source similar to 1ES0229+200, a blazar with hard intrinsic spectrum at redshift $z=0.14$, which is an ideal distance for potentially observing the effect. We study the possible response of a generic future Cherenkov telescope using a simplified model for the sensitivity, effective area and angular resol...

  2. Performance improvement of InGaN blue light-emitting diodes with several kinds of electron-blocking layers

    Institute of Scientific and Technical Information of China (English)

    Chen Jun; Fan Guang-Han; Zhang Yun-Yan; Pang Wei; Zheng Shu-Wen; Yao Guang-Rui

    2012-01-01

    The performance of lnGaN blue light-emitting diodes(LEDs)with different kinds of electron-blocking layers is investigated numerically.We compare the simulated emission spectra,electron and hole concentrations,euergy band diagrams,electrostatic fields,and internal quantum efficiencies of the LEDs.The LED using A1GaN with gradually increasing Al content from 0% to 20% as the electron-blocking layer(EBL)has a strong spectrum intensity,mitigates efficiency droop,and possesses higher output power compared with the LEDs with the other three types of EBLs.These advantages could be because of the lower electron leakage current and more effective hole injection.The optical performance of the specifically designed LED is also improved in the case of large injection current.

  3. Multivariate Analysis of Blood Transfusion Rates After Shoulder Arthroplasty.

    Science.gov (United States)

    King, Joseph J; Patrick, Matthew R; Schnetzer, Ryan E; Farmer, Kevin W; Struk, Aimee M; Garvan, Cyndi; Wright, Thomas W

    A retrospective review was performed of all shoulder arthroplasties with patients grouped on the basis of transfusion protocol time period. Group 1 had transfusions if postoperative hematocrit was multivariate analysis of significant bivariate factors were performed. Protocol change decreased transfusion rates from 16% (group 1, 153 arthroplasties) to 8% (group 2, 149 arthroplasties). Reverse shoulder arthroplasty (RTSA) transfusion rate decreased dramatically (from 24% to 5%). Transfusion rates after total shoulder arthroplasty (TSA) were low (4%) and after revision arthroplasty were high (21% + 27%) in both groups. Age, gender, heart disease, preoperative hematocrit, diagnosis, and estimated blood loss (EBL) were risk factors on bivariate analysis. Failed arthroplasty and fracture diagnoses carried high transfusion rates (25% + 28%). Logistic regression showed that low preoperative hematocrit, increased EBL, revision arthroplasty, and heart disease were transfusion risk factors. Protocol based on symptomatic anemia results in low transfusion rates after primary TSA and RTSA.

  4. Dark matter powered stars: Constraints from the extragalactic background light

    CERN Document Server

    Maurer, A; Kneiske, T; Elsässer, D; Hauschildt, P H; Horns, D

    2012-01-01

    The existence of predominantly cold non-baryonic dark matter is unambiguously demonstrated by several observations (e.g., structure formation, big bang nucleosynthesis, gravitational lensing, and rotational curves of spiral galaxies). A candidate well motivated by particle physics is a weakly interacting massive particle (WIMP). Self-annihilating WIMPs would affect the stellar evolution especially in the early universe. Stars powered by self-annihilating WIMP dark matter should possess different properties compared with standard stars. While a direct detection of such dark matter powered stars seems very challenging, their cumulative emission might leave an imprint in the diffuse metagalactic radiation fields, in particular in the mid-infrared part of the electromagnetic spectrum. In this work the possible contributions of dark matter powered stars (dark stars; DSs) to the extragalactic background light (EBL) are calculated. It is shown that existing data and limits of the EBL intensity can already be used to...

  5. Endemic Burkitt Lymphoma: Long-term Outcome in 87 Patients Who Presented With Paraplegia in Cameroon.

    Science.gov (United States)

    Hesseling, P B; Mbah, G; Kouya, F; Kimbi, C; Nfor, P; Kaah, J; Kuruvilla, R; Best, A; Wharin, P

    2015-01-01

    The reported long-term outcome of endemic Burkitt lymphoma (eBL) patients who present with paraplegia is largely unknown. Records of BL patients treated with comparable short-interval cyclophosphamide chemotherapy schedules between 2004 and 2014 at three Baptist mission hospitals in Cameroon were reviewed. Survivors were followed up and examined at home or in hospital. Eighty-seven of 948 (9.2%) patients had paraplegia at diagnosis. The survival rate in eBL patients with paraplegia at diagnosis was 33% (n = 29) after follow-up of between 2 and 96 (median 40) months. Seven patients (24%) had neurological sequelae and needed rehabilitation. There was no relationship between the duration of symptoms (4 weeks) and the survival rate or the risk to have neurological sequelae. The survival rate and risk for sequelae were similar in patients with confirmed St. Jude stage III and IV diseases.

  6. Fast patterning and dry-etch of SiNχ for high resolution nanoimprint templates

    Institute of Scientific and Technical Information of China (English)

    Shu Zhen; Wan Jing; Lu Bingrui; Xie Shenqi; Chen Yifang; Qu Xinping; Liu Ran

    2009-01-01

    We developed a simplified nanofabrication process for imprint templates by fast speed electron beam lithography (EBL) and a dry etch technique on a SiNx substrate, intended for large area manufacturing. To this end,the highly sensitive chemically amplified resist (CAR), NEB-22, with negative tone was used. The EBL process first defines the template pattern in NEB-22, which is then directly used as an etching mask in the subsequent reactive ion etching (RIE) on the SiNx to form the desired templates. The properties of both e-beam lithography and dry etch of NEB-22 were carefully studied, indicating significant advantages of this process with some drawbacks compared to when Cr was used as an etching mask. Nevertheless, our results open up a good opportunity to fabricate high resolution imprint templates with the prospect of wafer scale manufacturing.

  7. Axion-Like Particle Imprint in Cosmological Very-High-Energy Sources

    Energy Technology Data Exchange (ETDEWEB)

    Dominguez, A.; /Seville U. /IAA, Granada /Madrid, Autonoma U.; Sanchez-Conde, M.A.; /IAC, La Laguna /IAC, La Laguna /KIPAC, Menlo Park /SLAC; Prada, F.; /IAA, Granada

    2012-06-13

    Discoveries of very high energy (VHE) photons from distant blazars suggest that, after correction by extragalactic background light (EBL) absorption, there is a flatness or even a turn-up in their spectra at the highest energies that cannot be easily explained by the standard framework. Here, it is shown that a possible solution to this problem is achieved by assuming the existence of axion-like particles (ALPs) with masses {approx} 1 neV. The ALP scenario is tested making use of observations of the highest redshift blazars known in the VHE energy regime, namely 3C 279, 3C 66A, PKS 1222+216 and PG 1553+113. In all cases, better fits to the observed spectra are found when including ALPs rather than considering EBL only. Interestingly, quite similar critical energies for photon/ALP conversions are also derived, independently of the source considered.

  8. Rapid identification of genes controlling virulence and immunity in malaria parasites

    KAUST Repository

    Abkallo, Hussein M.

    2017-07-13

    Identifying the genetic determinants of phenotypes that impact disease severity is of fundamental importance for the design of new interventions against malaria. Here we present a rapid genome-wide approach capable of identifying multiple genetic drivers of medically relevant phenotypes within malaria parasites via a single experiment at single gene or allele resolution. In a proof of principle study, we found that a previously undescribed single nucleotide polymorphism in the binding domain of the erythrocyte binding like protein (EBL) conferred a dramatic change in red blood cell invasion in mutant rodent malaria parasites Plasmodium yoelii. In the same experiment, we implicated merozoite surface protein 1 (MSP1) and other polymorphic proteins, as the major targets of strain-specific immunity. Using allelic replacement, we provide functional validation of the substitution in the EBL gene controlling the growth rate in the blood stages of the parasites.

  9. Understanding the experiences of a group of Yemeni students in an ESL science class

    Science.gov (United States)

    Fradi, Gihan

    American classrooms are experiencing an influx of diverse language speaking students while for science educators the study of EBL students' learning in science classrooms is a relatively new field (Lee & Buxton, 2010). At the same time there is a growing emphasis on the importance of science practices (NGSS). This poses significant challenges for science educators who are enacting science curriculum that supports all students' learning. Supporting EBL students' academic achievement is significant because literacy is important for students' access to economic and social benefits that come with science literacy (Atwater, 1996). The purpose of this study was to examine the socio-linguistic challenges that a specific group of EBL students (Yemeni) faced and the extent to which such challenges affected their academic performance in science. These challenges are related to linguistic and cultural interactions, which can lead to conflicts between student and school, thereby interfering with the effectiveness of their education. This study also examined these students' and their science teacher's perspectives on strategies that can be used to facilitate their language acquisition during science class and help them become active participants in the school and classroom communities. The study used a qualitative interpretive research methodology and involved four Arab-American EBL students (two males and two females) from Yemen, who had been in the US for different periods of time. The amount of time these students had been in the US was important to examine differences in their acculturation and challenges they faced. Similarly, the use of female and male student participants was important to understand the impact of gender in the lived experiences of these students. The results of the study indicated that all the participants struggled with linguistic, social, and cultural aspects of their life in an American high school. These in turn led to a sense of being different

  10. Rapid identification of genes controlling virulence and immunity in malaria parasites

    Science.gov (United States)

    Xangsayarath, Phonepadith; Tang, Jianxia; Yahata, Kazuhide; Zoungrana, Augustin; Mitaka, Hayato; Acharjee, Arita; Datta, Partha P.; Hunt, Paul; Carter, Richard; Kaneko, Osamu; Mustonen, Ville; Pain, Arnab

    2017-01-01

    Identifying the genetic determinants of phenotypes that impact disease severity is of fundamental importance for the design of new interventions against malaria. Here we present a rapid genome-wide approach capable of identifying multiple genetic drivers of medically relevant phenotypes within malaria parasites via a single experiment at single gene or allele resolution. In a proof of principle study, we found that a previously undescribed single nucleotide polymorphism in the binding domain of the erythrocyte binding like protein (EBL) conferred a dramatic change in red blood cell invasion in mutant rodent malaria parasites Plasmodium yoelii. In the same experiment, we implicated merozoite surface protein 1 (MSP1) and other polymorphic proteins, as the major targets of strain-specific immunity. Using allelic replacement, we provide functional validation of the substitution in the EBL gene controlling the growth rate in the blood stages of the parasites. PMID:28704525

  11. Probing cosmological fields with VERITAS

    Science.gov (United States)

    Pueschel, Elisa

    2017-01-01

    The observed properties of active galactic nuclei carry the imprint of the magnetic fields and low-energy photon fields encountered by the gamma rays as they travel to the observer. VERITAS, a ground-based imaging atmospheric Cherenkov telescope array sensitive to gamma rays above 85 GeV, has collected a large set of observations of blazars with a range of redshifts, the furthest at a redshift of 0.9. These observations can be used to constrain two key cosmological observables: the spectral energy distribution of the extragalactic background light (EBL), and the strength of the intergalactic magnetic field (IGMF). We present the latest VERITAS efforts to constrain the EBL and IGMF.

  12. A hole accelerator for InGaN/GaN light-emitting diodes

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Zi-Hui; Liu, Wei; Tan, Swee Tiam; Ji, Yun; Wang, Liancheng; Zhu, Binbin; Zhang, Yiping; Lu, Shunpeng; Zhang, Xueliang; Hasanov, Namig; Sun, Xiao Wei, E-mail: EXWSUN@ntu.edu.sg, E-mail: VOLKAN@stanfordalumni.org [LUMINOUS Centre of Excellence for Semiconductor Lighting and Displays, School of Electrical and Electronic Engineering, School of Physical and Mathematical Sciences, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (Singapore); Demir, Hilmi Volkan, E-mail: EXWSUN@ntu.edu.sg, E-mail: VOLKAN@stanfordalumni.org [LUMINOUS Centre of Excellence for Semiconductor Lighting and Displays, School of Electrical and Electronic Engineering, School of Physical and Mathematical Sciences, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (Singapore); Department of Electrical and Electronics, Department of Physics, and UNAM-Institute of Material Science and Nanotechnology, Bilkent University, TR-06800 Ankara (Turkey)

    2014-10-13

    The quantum efficiency of InGaN/GaN light-emitting diodes (LEDs) has been significantly limited by the insufficient hole injection, and this is caused by the inefficient p-type doping and the low hole mobility. The low hole mobility makes the holes less energetic, which hinders the hole injection into the multiple quantum wells (MQWs) especially when a p-type AlGaN electron blocking layer (EBL) is adopted. In this work, we report a hole accelerator to accelerate the holes so that the holes can obtain adequate kinetic energy, travel across the p-type EBL, and then enter the MQWs more efficiently and smoothly. In addition to the numerical study, the effectiveness of the hole accelerator is experimentally shown through achieving improved optical output power and reduced efficiency droop for the proposed InGaN/GaN LED.

  13. Comparison of technologies for nano device prototyping with a special focus on ion beams: A review

    Science.gov (United States)

    Bruchhaus, L.; Mazarov, P.; Bischoff, L.; Gierak, J.; Wieck, A. D.; Hövel, H.

    2017-03-01

    Nano device prototyping (NDP) is essential for realizing and assessing ideas as well as theories in the form of nano devices, before they can be made available in or as commercial products. In this review, application results patterned similarly to those in the semiconductor industry (for cell phone, computer processors, or memory) will be presented. For NDP, some requirements are different: thus, other technologies are employed. Currently, in NDP, for many applications direct write Gaussian vector scan electron beam lithography (EBL) is used to define the required features in organic resists on this scale. We will take a look at many application results carried out by EBL, self-organized 3D epitaxy, atomic probe microscopy (scanning tunneling microscope/atomic force microscope), and in more detail ion beam techniques. For ion beam techniques, there is a special focus on those based upon liquid metal (alloy) ion sources, as recent developments have significantly increased their applicability for NDP.

  14. Embedded top-coat for reducing the effect out of band radiation in EUV lithography

    Science.gov (United States)

    Du, Ke; Siauw, Meiliana; Valade, David; Jasieniak, Marek; Voelcker, Nico; Trefonas, Peter; Thackeray, Jim; Blakey, Idriss; Whittaker, Andrew

    2017-03-01

    Out of band (OOB) radiation from the EUV source has significant implications for the performance of EUVL photoresists. Here we introduce a surface-active polymer additive, capable of partitioning to the top of the resist film during casting and annealing, to protect the underlying photoresist from OOB radiation. Copolymers were prepared using reversible addition-fragmentation chain transfer (RAFT) polymerization, and rendered surface active by chain extension with a block of fluoro-monomer. Films were prepared from the EUV resist with added surface-active Embedded Barrier Layer (EBL), and characterized using measurements of contact angles and spectroscopic ellipsometry. Finally, the lithographic performance of the resist containing the EBL was evaluated using Electron Beam Lithography exposure

  15. Single-spot e-beam lithography for defining large arrays of nano-holes

    DEFF Research Database (Denmark)

    Højlund-Nielsen, Emil; Greibe, Tine; Mortensen, N. Asger

    2014-01-01

    Efficient nanoscale patterning of large areas is required for sub-wavelength optics. Here we use the single-spot exposure strategy, where electron beam lithography (EBL) with a focused Gaussian beam is used to define shapes directly. The serial technique is optimized on the JEOL JBX-9500FS 100 ke......V prototype EBL system for speed and pattern fidelity to a minimum writing time of around 30 min/cm2 for 200 nm periods in 2D lattices. The machine time and feasibility of the method are assessed in terms of the trade-off between high current and large writing field. © 2014 Elsevier B.V. All rights reserved....

  16. On the Enhancement of Light Absorption in Si Solar Cells by Front-Side Plasmonic Scattering

    DEFF Research Database (Denmark)

    Villesen, Thorbjørn Falk

    og ikke kan udnyttes i solcellen. Hovedparten af dette PhD projekt har været fokuseret på at løse dette problem, ved at modificere partiklernes plasmoniske respons. Elektron stråle mikroskopi (EBL) blev brugt til at studere effekten af form, størrelse og det dielektriske nærmiljø af partiklerne...... er et forsøg på at løse dette problem. Ved hjælp af EBL har vi lavet tynde striber af Pd$_2$Si oven på en silicium overflade, og derved tilladt at lys kan passere forbi striberne, ind i siliciummet. Dette sænker absorptionstab i det metalliske lag. Ideen er at bruge Pd$_2$Si striberne både til...

  17. Learning Plan Schemata From Observation: Explanation-Based Learning for Plan Recognition

    Science.gov (United States)

    1990-01-01

    connect actions causally, fill in missing actions, resolve anaphoric refer- ences, and so on. Examples of narrative understanding systems that use schema...domain- independent EBL system (Mooney, 1990; Mooney & Bennett, 1986).’ This generalizer computes the minimal variable bindings needed to allow the...passing is a simple computational process which does not keep track of variable bindings nor examine the consistency and explanatory power of the

  18. Development of molecular resists based on Phenyl[4]calixarene derivatives.

    Science.gov (United States)

    Echigo, Masatoshi; Hayashi, Hiromi; Oizumi, Hiroaki; Matsumaro, Kazuyuki; Itani, Toshiro

    2010-04-01

    We have developed negative-tone molecular resist based on C-4-cyclohexylphenylcalix[4]resorcinarene(MGR108) and positive-tone molecular resist based on protected C-4-isopropylphenylcalix[4]resorcinarene (MGR104P). Both MGR108 and MGR104P showed high solubility in both conventional resist solvents such as propylene glycol monomethyl ether and conventional alkaline developer of 0.26N TMAHaq. In this paper, we show current performance of resists by EB lithography (EBL) and EUV lithography (EUVL).

  19. Adding SPICE to a Library Internet Site: A Recipe to Enhance Usability

    OpenAIRE

    Ingrid Tonnison; Larnish Harije; Suzanne Lewis; Lisa Cotter

    2006-01-01

    Objective - To produce a highly- usable intranet site, use the project to explore the practical application of evidence-based librarianship (EBL), and refine the library's project management methodology. Methods - Evidence was gathered via a literature review, an online survey, scenario-based usability testing, and the completion of a usability checlist. Usability issues were then addressed, guided by the Research-Based Web Design and Usability Guidelines. Results - After a preliminary ...

  20. The Appropriateness of Hierarchies (Editorial)

    OpenAIRE

    2010-01-01

    In the early days of EBLIP, then referred to as evidence based librarianship (EBL), there were calls to strengthen our research base with "better" forms of evidence. These proposed better quality research methods were all quantitative and I admit myself to saying that ‚librarianship tends to reflect more qualitative, social sciences/humanities in its research methods and study types which tend to be less rigorous and more prone to bias‛ (Crumley and Koufogiannakis 2002, p.61). Although this w...

  1. Sequence Classification: 885394 [

    Lifescience Database Archive (English)

    Full Text Available 703); The expression pattern of this gene is described in PMID:12000842; possible frameshift detected when compared...Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|23619146|ref|NP_705108.1| Slight di...fference exist when compared to the published sequence of EBL-1 from Dd2 strain of P. falciparum (PMID:10613

  2. Cu vi parolas Esperante?

    Institute of Scientific and Technical Information of China (English)

    Andrzej; Pettyn

    1999-01-01

    LA DEKA LECIONOKiom da mono vi bezonas?—Barbara:Mi foriras aeti ion pormani.u vi deziras ion de mi?—Sinjoro Petro(la edzo de Barbara):Aetu por mi skatolon da cigaredoj aǔeble...aetu por mi du skatolojn dacigaredoj kaj unu skatolon da alume-toj.—B:Bone.u vi ankoraǔ deziras ion?—P:Ne,dankon.Estasio.u vihavas monon?

  3. Robot assisted laparoscopic radical prostatectomy: assistant's seniority has no influence on perioperative course.

    Science.gov (United States)

    Abu-Ghanem, Yasmin; Erlich, Tomer; Ramon, Jacob; Dotan, Zohar; Zilberman, Dorit E

    2016-11-09

    An experienced surgical team, in general, and the surgeon assistant in particular are believed to play a critical role in the operation's safety and success. We sought to explore whether the assistant's seniority influences perioperative course following robot assisted laparoscopic radical prostatectomy (RALP). We reviewed our prospective registry database of RALP cases performed by a single surgeon who during the study period was beyond his learning curve. The following parameters were documented and analyzed: patient's age, body mass index (BMI), associated comorbidities, previous abdominal surgeries, assistant's identity, total and skin-to-skin operative time (tOT, ssOT, respectively), estimated blood loss (EBL), immediate post-operative complications, length of stay (LOS), and prostate weight per final pathology report. Univariate analysis and Spearman's correlation test were used to evaluate whether the assistant's seniority influenced perioperative course. Between the years 2011-2015, 106 consecutive cases were retrieved and analyzed. Prostate weight was found to be associated with longer tOT (Spearman's ρ = 0.34, p < 0.001), ssOT (0.3, p < 0.01) and increased EBL (0.28, p < 0.01). Patient's age, BMI, associated comorbidities, and previous abdominal surgeries were found to have no influence on neither tOT, ssOT nor EBL. Three assistants' subgroups were identified (seniors, PGY 1-3, PGY 4-6). The assistant's seniority was found to have no influence on tOT, ssOT, EBL, immediate post-operative complications and LOS. Same results were obtained following prostate size adjustments. The assistant's seniority has no influence on perioperative course following RALP. Consequently, given a highly experienced primary surgeon, a less experienced assistant can be safely incorporated into this procedure.

  4. Arsenic-induced genotoxic responses and their amelioration by diphenylene iodonium, 24-epibrassinolide and proline in Glycine max L.

    Science.gov (United States)

    Chandrakar, Vibhuti; Yadu, Bhumika; Meena, Rakesh Kumar; Dubey, Amit; Keshavkant, S

    2017-03-01

    Presence of the toxic metalloid, "arsenic (As)" is ubiquitous in the environment especially in the soil and water. Its excess availability in the soil retards growth and metabolism of plants via (a) slowing down the cell division/elongation, (b) overproduction of reactive oxygen species (ROS), (c) modulation of antioxidant enzymes, and (d) alteration of DNA profile/genomic template stability (GTS). In the current study, diphenylene iodonium (DPI), 24-epibrassinolide (EBL) and proline (Pro) were used to analyze their roles in eliminating the adverse effects of As. Glycine max L. (variety JS 335) seeds were subjected to As (75 μM, Sodium arsenite was used as source of As), and in combination with DPI (10 μM), EBL (0.5 μM) or Pro (10 mM), for five consecutive days, and effects of these treatment combinations were analyzed on germination percentage, biomass, membrane stability, GTS and expressions of defensive genes. In addition, the levels of As, ROS, malondialdehyde, DNA content, oxidation, fragmentation, polymorphism, DNase activity, endogenous Pro and pyrroline-5-carboxylate synthetase activity were evaluated. The results indicated that the treatments of DPI, EBL or Pro are capable to alleviate detrimental effects of As, gauged from above variables, but with different magnitudes. Apropos As-stress mitigation, Pro was found to be the most effective under the confines of the study protocol. This study certainly provides new ideas for intensifying studies to unravel elusive central mechanism of amelioration involving use of DPI, EBL or Pro in plants with confirmed As-toxicity. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  5. Is There a Role for an Ultrasonic Bone-Cutting Device in Adult Spinal Deformity: A Safety and Reproducibility Study

    Directory of Open Access Journals (Sweden)

    Pooria Hosseini

    2016-07-01

    Full Text Available Background Ultrasonic bone-cutting devices (UBC are new cutting tools and have low frequency ultrasonic blade. There is limited data on the safety and effectiveness of using ultrasonic bone-cutting devices in the treatment of adult spinal deformities (ASD. Objectives This Retrospective review of prospectively collected data was designed to determine if the use of an ultrasonic bone-cutting device is safe in the adult spinal deformity population and to compare its effectiveness in blood loss reduction by using a comparison group from a prospective multicenter database of adult spinal deformity patients. Methods Nineteen consecutive surgical ASD cases in which the UBC was used were compared with 19 propensity-matched cases from a prospective ASD database in which conventional bone cutting instruments were used. The two groups were matched based on age, ASA, and number of levels fused posteriorly. The need for blood transfusion, volume of blood transfusion if required, estimated blood loss (EBL, and total operating time were compared between the two groups. Data were analyzed using non-parametric Mann-Whitney U test and Spearman’s Correlation test (P < 0.05. Results There was no statistically significant difference in any measured parameter between the two groups. While the EBL difference between the two groups (925 mL in the study group vs. 1628 mL in the control group was not statistically significant (P = 0.142, the 703 mL difference is clinically relevant. In addition, no complications directly related to the use of the UBC were reported. Conclusions The use of an ultrasonic bone-cutting device was shown to be safe and effective in the surgical treatment of ASD. It resulted in a 43% reduction in EBL, which was clinically relevant and statistically non-significant, without the addition of any complications. We did not identify statistical differences in transfusion rates, EBL, or operative time, which may be due to our small sample size.

  6. Molecular characterization of bovine leukemia virus from Moldovan dairy cattle

    OpenAIRE

    Pluta, Aneta; Rola-Łuszczak, Marzena; Kubiś, Piotr; Balov, Svetlana; Moskalik, Roman; Choudhury, Bhudipa; Kuźmak, Jacek

    2017-01-01

    Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis (EBL), a disease that has worldwide distribution. Whilst it has been eradicated in most of Western Europe and Scandinavia, it remains a problem in other regions, particularly Eastern Europe and South America. For this study, in 2013, 24 cattle from three farms in three regions of Moldova were screened by ELISA and nested PCR. Of these cattle, 14 which were PCR positive, and these were molecularly characterized base...

  7. Extragalactic background light from hierarchical galaxy formation. Gamma-ray attenuation up to the epoch of cosmic reionization and the first stars

    Energy Technology Data Exchange (ETDEWEB)

    Inoue, Yoshiyuki [Stanford Univ., CA (United States). Kavli Inst. for Particle Astrophysics and Cosmology; Inoue, Susumu [Max Planck Inst. for Nuclear Physics, Heidelberg (Germany); Univ. of Tokyo (Japan). Inst. for Cosmic Ray Research; Kobayashi, Masakazu A. R. [Ehime Univ., Matsuyama (Japan). Research Center for Space and Cosmic Evolution; Makiya, Ryu [Kyoto Univ. (Japan). Dept. of Astronomy; Niino, Yuu [National Astronomical Observatory of Japan, Mitaka (Tokyo). Optical and Infrared Astronomy Division; Totani, Tomonori [Kyoto Univ. (Japan). Dept. of Astronomy

    2013-04-26

    Here, we present a new model of the extragalactic background light (EBL) and corresponding γγ opacity for intergalactic gamma-ray absorption from z = 0 up to z = 10, based on a semi-analytical model of hierarchical galaxy formation that reproduces key observed properties of galaxies at various redshifts. Including the potential contribution from Population III stars and following the cosmic reionization history in a simplified way, the model is also broadly consistent with available data concerning reionization, particularly the Thomson scattering optical depth constraints from Wilkinson Microwave Anisotropy Probe (WMAP). In comparison with previous EBL studies up to z ~ 3-5, our predicted γγ opacity is in general agreement for observed gamma-ray energy below 400/(1 + z) GeV, whereas it is a factor of ~2 lower above this energy because of a correspondingly lower cosmic star formation rate, even though the observed ultraviolet (UV) luminosity is well reproduced by virtue of our improved treatment of dust obscuration and direct estimation of star formation rate. Moreover, the horizon energy at which the gamma-ray opacity is unity does not evolve strongly beyond z ~ 4 and approaches ~20 GeV. The contribution of Population III stars is a minor fraction of the EBL at z = 0, and is also difficult to distinguish through gamma-ray absorption in high-z objects, even at the highest levels allowed by the WMAP constraints. Nevertheless, the attenuation due to Population II stars should be observable in high-z gamma-ray sources by telescopes such as Fermi or the Cherenkov Telescope Array and provide a valuable probe of the evolving EBL in the rest-frame UV. Our detailed results of our model are publicly available in numerical form at http://www.slac.stanford.edu/~yinoue/Download.html.

  8. Problem-based learning principles and application to practice : an example from a practitioner-orientated course

    OpenAIRE

    Dangerfield, Polly

    2006-01-01

    Highly motivated, well-read learners are advantageous in any classroom, from undergraduate programmes to taught doctorate settings, and these dual attributes have encouraged and inspired increasing numbers of HE tutors to introduce modifications on what has become known as PBL (problem-based learning), incorporating this element into their courses (Stevenson, 2005). Whatever its title - it is diversely known as PBL, EBL (enquiry-based learning), and PSL (problem-solving learning) - the criter...

  9. Robotic partial nephrectomy for renal tumours in obese patients: Perioperative outcomes in a multi-institutional analysis

    Science.gov (United States)

    Abdullah, Newaj; Dalela, Deepansh; Barod, Ravi; Larson, Jeff; Johnson, Michael; Mass, Alon; Zargar, Homayoun; Allaf, Mohamad; Bhayani, Sam; Stifelman, Michael; Kaouk, Jihad; Rogers, Craig

    2015-01-01

    Introduction: We sought to evaluate the association of obesity with surgical outcomes of robotic partial nephrectomy (RPN) using a large, multicentre database. Methods: We identified 1836 patients who underwent RPN from five academic centres from 2006–2014. A total of 806 patients were obese (body mass index [BMI] ≥30 kg/m2). Patient characteristics and outcomes were compared between obese and non-obese patients. Multivariable analysis was used to assess the association of obesity on RPN outcomes. Results: A total of 806 (44%) patients were obese with median BMI of 33.8kg/m2. Compared to non-obese patients, obese patients had greater median tumour size (2.9 vs. 2.5cm, p<0.001), mean RENAL nephrometry score (7.3 vs. 7.1, p=0.04), median operating time (176 vs. 165 min, p=0.002), and median estimated blood loss (EBL, 150 vs. 100 ml, p=0.002), but no difference in complications. Obesity was not an independent predictor of operative time or EBL on regression analysis. Among obese patients, males had a greater EBL (150 vs. 100 ml, p<0.001), operative time (180 vs. 166 min, p<0.001) and warm ischemia time (WIT, 20 vs. 18, p=0.001), and male sex was an independent predictor of these outcomes on regression analysis. Conclusions: In this large, multicentre study on RPN, obesity was not associated with increased complications and was not an independent predictor of operating time or blood loss. However, in obese patients, male gender was an independent predictor of greater EBL, operative time, and WIT. Our results indicate that obesity alone should not preclude consideration for RPN. PMID:26788235

  10. Effect of volume replacement with hydroxyethyl starch solution on splanchnic oxygenation in patients undergoing cytoreductive surgery for ovarian cancer

    Institute of Scientific and Technical Information of China (English)

    郭向阳; 徐仲煌; 任洪智; 罗爱伦; 黄宇光; 叶铁虎

    2003-01-01

    Objective To investigate the effectiveness of using a medium molecular weight hydroxyethyl starch solution (HES) administered as a replacement for estimated blood loss (EBL) during cytoreductive surgery for ovarian cancer on splanchnic oxygenation. Methods Forty-two patients undergoing cytoreductive surgery for ovarian cancer were enrolled in this prospective randomized study. As soon as the EBL exceeded 10% but was less than 20% of the estimated blood volume, the patients were randomly assigned to receive either a volume of lactated Ringer's solution (LRS) equal to three times the EBL (LRS group, n=22) or a volume of 6% HES equal to the EBL (HES group, n=20). Tissue oxygenation was assessed indirectly by measuring tonometric parameters, including the difference between gastric intramucosal PsCO2 and arterial PaCO2 (Ps-a CO2 gap), gastric intramucosal pH (pHi) and arterial lactate acid concentration at 30 min after induction of anesthesia (baseline value), 1 hour and 2 hours after skin incision, and at the end of surgery. Results At the end of surgery,the Ps-a CO2 gap in the HES group (8.7±1.6 mmHg) was significantly lower than that of the LRS group (18.74±4.4 mmHg, P<0.01), while the pHi (7.30±0.05 mmHg) in the HES group was significantly higher than that of the LRS group (7.21±0.07 mmHg, P<0.01). There was no significant difference between the two groups in terms of arterial lactate acid concentration. Conclusion In patients undergoing major surgery with relatively large blood losses, volume resuscitation with medium molecular weight hydroxyethyl starch solution may improve splanchnic blood flow and tissue oxygenation.

  11. Comparison of robotic surgery with laparoscopy and laparotomy for treatment of endometrial cancer: a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Longke Ran

    Full Text Available To compare the relative merits among robotic surgery, laparoscopy, and laparotomy for patients with endometrial cancer by conducting a meta-analysis.The MEDLINE, Embase, PubMed, Web of Science, and Cochrane Library databases were searched. Studies clearly documenting a comparison between robotic surgery and laparoscopy or between robotic surgery and laparotomy for endometrial cancer were selected. The outcome measures included operating time (OT, number of complications, length of hospital stay (LOHS, estimated blood loss (EBL, number of transfusions, total lymph nodes harvested (TLNH, and number of conversions. Pooled odds ratios and weighted mean differences with 95% confidence intervals were calculated using either a fixed-effects or random-effects model.Twenty-two studies were included in the meta-analysis. These studies involved a total of 4420 patients, 3403 of whom underwent both robotic surgery and laparoscopy and 1017 of whom underwent both robotic surgery and laparotomy. The EBL (p = 0.01 and number of conversions (p = 0.0008 were significantly lower and the number of complications (p<0.0001 was significantly higher in robotic surgery than in laparoscopy. The OT, LOHS, number of transfusions, and TLNH showed no significant differences between robotic surgery and laparoscopy. The number of complications (p<0.00001, LOHS (p<0.00001, EBL (p<0.00001, and number of transfusions (p = 0.03 were significantly lower and the OT (p<0.00001 was significantly longer in robotic surgery than in laparotomy. The TLNH showed no significant difference between robotic surgery and laparotomy.Robotic surgery is generally safer and more reliable than laparoscopy and laparotomy for patients with endometrial cancer. Robotic surgery is associated with significantly lower EBL than both laparoscopy and laparotomy; fewer conversions but more complications than laparoscopy; and shorter LOHS, fewer complications, and fewer transfusions but a longer OT

  12. Enquiry-based learning and formative assessment environments: student perspectives

    OpenAIRE

    Sambell, Kay

    2010-01-01

    This paper outlines case study research into first-year students’ experiences of enquiry based learning (EBL) on a year-long introductory theory module. Students were supported to carry out a series of authentic small-scale enquiries involving: • working in research teams; • gathering, disseminating and analysing data from the field; • sharing their interim findings as ‘work-in-progress’ reports; and • becoming involved in peer communities via a student conference. Semi-structured interviews ...

  13. Mechanism of hole injection enhancement in light-emitting diodes by inserting multiple hole-reservoir layers in electron blocking layer

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Yukun; Wang, Shuai; Feng, Lungang; Li, Yufeng; Ding, Wen [Key Laboratory of Physical Electronics and Devices of Ministry of Education and Shaanxi Provincial Key Laboratory of Photonics and Information Technology, Xi' an Jiaotong University, Xi' an, Shaanxi 710049 (China); Solid-State Lighting Engineering Research Center, Xi' an Jiaotong University, Xi' an, Shaanxi 710049 (China); Yun, Feng, E-mail: fyun2010@mail.xjtu.edu.cn [Key Laboratory of Physical Electronics and Devices of Ministry of Education and Shaanxi Provincial Key Laboratory of Photonics and Information Technology, Xi' an Jiaotong University, Xi' an, Shaanxi 710049 (China); Solid-State Lighting Engineering Research Center, Xi' an Jiaotong University, Xi' an, Shaanxi 710049 (China); Shaanxi Supernova Lighting Technology Co. Ltd, Xi' an, Shaanxi 710075 (China); Su, Xilin [Shaanxi Supernova Lighting Technology Co. Ltd, Xi' an, Shaanxi 710075 (China); Guo, Maofeng [Solid-State Lighting Engineering Research Center, Xi' an Jiaotong University, Xi' an, Shaanxi 710049 (China); Shaanxi Supernova Lighting Technology Co. Ltd, Xi' an, Shaanxi 710075 (China); Zhang, Ye [Solid-State Lighting Engineering Research Center, Xi' an Jiaotong University, Xi' an, Shaanxi 710049 (China)

    2016-03-14

    In this study, gallium nitride (GaN) based light-emitting diodes (LEDs) with single and multiple hole-reservoir layers (HRLs) inserted in the electron-blocking layer (EBL) have been investigated numerically and experimentally. According to simulation results, a better electron confinement and a higher hole injection level can be achieved by the multiple HRLs inserted in the EBL region. To further reveal the underlying mechanism of hole injection enhancement experimentally, the active regions were intentionally designed to emit photons with three different wavelengths of 440 nm, 460 nm, and 480 nm, respectively. Based on the experimental results of photoluminescence (PL) and time-resolved PL (TRPL) measurements conducted at 298 K, the remarkable enhancement (148%) of PL intensities and significant increase in the decay times of the quantum wells close to p-GaN can be obtained. Therefore, the mechanism is proposed that carriers are able to reserve in the EBL region with multiple HRLs for a much longer time. Meanwhile, carriers could diffuse into the active region by tunnelling and/or thermo-electronic effect and then recombine efficiently, leading to the better carrier reservoir effect and higher hole injection in LEDs. As a result, by inserting multiple HRLs in the EBL region instead of single HRL, the experimental external quantum efficiency is enhanced by 19.8%, while the serious droop ratio is markedly suppressed from 37.0% to 27.6% at the high current injection of 100 A/cm{sup 2}.

  14. Extragalactic background light: a measurement at 400 nm using dark cloud shadow*†- I. Low surface brightness spectrophotometry in the area of Lynds 1642

    Science.gov (United States)

    Mattila, K.; Lehtinen, K.; Väisänen, P.; von Appen-Schnur, G.; Leinert, Ch.

    2017-09-01

    We present the method and observations for the measurement of the Extragalactic Background Light (EBL) utilizing the shadowing effect of a dark cloud. We measure the surface brightness difference between the opaque cloud core and its unobscured surroundings. In the difference the large atmospheric and Zodiacal light components are eliminated and the only remaining foreground component is the scattered starlight from the cloud itself. Although much smaller, its separation is the key problem in the method. For its separation we use spectroscopy. While the scattered starlight has the characteristic Fraunhofer lines and 400 nm discontinuity, the EBL spectrum is smooth and without these features. Medium resolution spectrophotometry at λ = 380-580 nm was performed with VLT/FORS at ESO of the surface brightness in and around the high-galactic-latitude dark cloud Lynds 1642. Besides the spectrum for the core with AV ≳ 15 mag, further spectra were obtained for intermediate-opacity cloud positions. They are used as proxy for the spectrum of the impinging starlight spectrum and to facilitate the separation of the scattered starlight (cf. Paper II; Mattila et al.). Our spectra reach a precision of ≲ 0.5 × 10-9 erg cm-2 s-1 sr-1 Å-1 as required to measure an EBL intensity in range of ∼1 to a few times 10-9 erg cm-2 s-1 sr-1 Å-1. Because all surface brightness components are measured using the same equipment, the method does not require unusually high absolute calibration accuracy, a condition that has been a problem for some previous EBL projects.

  15. Nonrelativistic QED expansion for the electron self-energy

    Science.gov (United States)

    Patkóš, V.; Šimsa, D.; Zamastil, J.

    2017-01-01

    The recently proposed relativistic multipole expansion (RME) of the self-energy effect suggests some observations on the nonrelativistic expansion of the effect. First, the nature of the series for the one-loop self-energy of an electron bound by the Coulomb field of the nucleus is clarified. It is shown that the expansion of the energy shift caused by the self-energy effect contains terms of the form α (Zα ) 7ln(Z α ) , α (Zα ) 8ln3(Z α ) , α (Zα ) 9ln2(Z α ) , α (Zα ) 10ln4(Z α ) , and so on. Here Z is the charge of the nucleus. The origin of these terms is traced back to the logarithmic divergence of the Dirac S -wave function at the origin. These terms eventually lead to breakdown of the nonrelativistic quantum electrodynamics approach. Second, at leading order relativistic multipole expansion requires an evaluation of the "extended Bethe logarithm" (EBL). When expanded in series in Z α EBL reduces at leading order to the ordinary Bethe logarithm. However, it is argued that it is both more accurate and easier to calculate the EBL than the ordinary Bethe logarithm. Both variants of the Bethe logarithm can be calculated by means of the pseudostate method. An improvement of this method is suggested. Finally, the contribution of the combined self-energy vacuum polarization contribution to the Lamb shift in muonic hydrogen for the 1 s -4 s and 2 p -4 p states by means of the EBL is calculated. For cases that had already been calculated the results reported here are more accurate than the previous ones.

  16. Influence of electron-beam lithography exposure current level on the transport characteristics of graphene field effect transistors

    Science.gov (United States)

    Kang, Sangwoo; Movva, Hema C. P.; Sanne, Atresh; Rai, Amritesh; Banerjee, Sanjay K.

    2016-03-01

    Many factors have been identified to influence the electrical transport characteristics of graphene field-effect transistors. In this report, we examine the influence of the exposure current level used during electron beam lithography (EBL) for active region patterning. In the presence of a self-assembled hydrophobic residual layer generated by oxygen plasma etching covering the top surface of the graphene channel, we show that the use of low EBL current level results in higher mobility, lower residual carrier density, and charge neutrality point closer to 0 V, with reduced device-to-device variations. We show that this correlation originates from the resist heating dependent release of radicals from the resist material, near its interface with graphene, and its subsequent trapping by the hydrophobic polymer layer. Using a general model for resist heating, we calculate the difference in resist heating for different EBL current levels. We further corroborate our argument through control experiments, where radicals are either intentionally added or removed by other processes. We also utilize this finding to obtain mobilities in excess of 18 000 cm2/V s on silicon dioxide substrates. We believe these results are applicable to other 2D materials such as transition metal dichalcogenides and nanoscale devices in general.

  17. Developing a culture of lifelong learning in a library environment.

    Science.gov (United States)

    Giuse, N B; Kafantaris, S R; Huber, J T; Lynch, F; Epelbaum, M; Pfeiffer, J

    1999-01-01

    Between 1995 and 1996, the Annette and Irwin Eskind Biomedical Library (EBL) at Vanderbilt University Medical Center (VUMC) radically revised the model of service it provides to the VUMC community. An in-depth training program was developed for librarians, who began to migrate to clinical settings and establish clinical librarianship and information brokerage services beyond the library's walls. To ensure that excellent service would continue within the library, EBL's training program was adapted for library assistants, providing them with access to information about a wide variety of work roles and processes over a four to eight-month training period. Concurrently, customer service areas were reorganized so that any question--whether reference or circulation--could be answered at any of four service points, eliminating the practice of passing customers from person to person between the reference and circulation desks. To provide an incentive for highly trained library assistants to remain at EBL, management and library assistants worked together to redesign the career pathway based on defined stages of achievement, self-directed participation in library-wide projects, and demonstrated commitment to lifelong learning. Education and training were the fundamental principles at the center of all this activity.

  18. Enhancing Carrier Injection Using Graded Superlattice Electron Blocking Layer for UVB Light-Emitting Diodes

    KAUST Repository

    Janjua, Bilal

    2014-12-01

    We have studied enhanced carrier injection by having an electron blocking layer (EBL) based on a graded superlattice (SL) design. Here, we examine, using a selfconsistent 6 × 6 k.p method, the energy band alignment diagrams under equilibrium and forward bias conditions while also considering carrier distribution and recombination rates (Shockley-Read-Hall, Auger, and radiative recombination rates). The graded SL is based on AlxGa1-xN (larger bandgap) Al0:5Ga0:5N (smaller bandgap) SL, where x is changed from 0.8 to 0.56 in steps of 0.06. Graded SL was found to be effective in reducing electron leakage and enhancing hole injection into the active region. Due to our band engineering scheme for EBL, four orders-of-magnitude enhancement were observed in the direct recombination rate, as compared with the conventional bulk EBL consisting of Al0:8Ga0:2N. An increase in the spatial overlap of carrier wavefunction was obtained due to polarization-induced band bending in the active region. An efficient single quantum-well ultraviolet-B light-emitting diode was designed, which emits at 280 nm. This is the effective wavelength for water disinfection application, among others.

  19. Gamma-Rays from the Quasar PKS 1441+25: Story of an Escape

    Science.gov (United States)

    Abeysekara, A. U.; Archambault, S.; Archer, A.; Aune, T.; Barnacka, A.; Benbow, W.; Bird, R.; Biteau, J.; Buckley, J. H.; Bugaev, V.; Cardenzana, J. V.; Cerruti, M.; Chen, X.; Christiansen, J. L.; Ciupik, L.; Connolly, M. P.; Coppi, P.; Cui, W.; Dickinson, H. J.; Dumm, J.; Eisch, J. D.; Errando, M.; Falcone, A.; Feng, Q.; Finley, J. P.; Fleischhack, H.; Flinders, A.; Fortin, P.; Fortson, L.; Furniss, A.; Gillanders, G. H.; Griffin, S.; Grube, J.; Gyuk, G.; Hütten, M.; Håkansson, N.; Hanna, D.; Holder, J.; Humensky, T. B.; Johnson, C. A.; Kaaret, P.; Kar, P.; Kelley-Hoskins, N.; Khassen, Y.; Kieda, D.; Krause, M.; Krennrich, F.; Kumar, S.; Lang, M. J.; Maier, G.; McArthur, S.; McCann, A.; Meagher, K.; Moriarty, P.; Mukherjee, R.; Nieto, D.; O'Faoláin de Bhróithe, A.; Ong, R. A.; Otte, A. N.; Park, N.; Perkins, J. S.; Petrashyk, A.; Pohl, M.; Popkow, A.; Pueschel, E.; Quinn, J.; Ragan, K.; Ratliff, G.; Reynolds, P. T.; Richards, G. T.; Roache, E.; Rousselle, J.; Santander, M.; Sembroski, G. H.; Shahinyan, K.; Smith, A. W.; Staszak, D.; Telezhinsky, I.; Todd, N. W.; Tucci, J. V.; Tyler, J.; Vassiliev, V. V.; Vincent, S.; Wakely, S. P.; Weiner, O. M.; Weinstein, A.; Wilhelm, A.; Williams, D. A.; Zitzer, B.; VERITAS; Smith, P. S.; SPOL; Holoien, T. W.-S.; Prieto, J. L.; Kochanek, C. S.; Stanek, K. Z.; Shappee, B.; ASAS-SN; Hovatta, T.; Max-Moerbeck, W.; Pearson, T. J.; Reeves, R. A.; Richards, J. L.; Readhead, A. C. S.; OVRO; Madejski, G. M.; NuSTAR; Djorgovski, S. G.; Drake, A. J.; Graham, M. J.; Mahabal, A.; CRTS

    2015-12-01

    Outbursts from gamma-ray quasars provide insights on the relativistic jets of active galactic nuclei and constraints on the diffuse radiation fields that fill the universe. The detection of significant emission above 100 GeV from a distant quasar would show that some of the radiated gamma-rays escape pair-production interactions with low-energy photons, be it the extragalactic background light (EBL), or the radiation near the supermassive black hole lying at the jet’s base. VERITAS detected gamma-ray emission up to ˜200 GeV from PKS 1441+25 (z = 0.939) during 2015 April, a period of high activity across all wavelengths. This observation of PKS 1441+25 suggests that the emission region is located thousands of Schwarzschild radii away from the black hole. The gamma-ray detection also sets a stringent upper limit on the near-ultraviolet to near-infrared EBL intensity, suggesting that galaxy surveys have resolved most, if not all, of the sources of the EBL at these wavelengths.

  20. Exploring the Potential of Nucleic Acid Bases in Organic Light Emitting Diodes.

    Science.gov (United States)

    Gomez, Eliot F; Venkatraman, Vishak; Grote, James G; Steckl, Andrew J

    2015-12-01

    Naturally occurring biomolecules have increasingly found applications in organic electronics as a low cost, performance-enhancing, environmentally safe alternative. Previous devices, which incorporated DNA in organic light emitting diodes (OLEDs), resulted in significant improvements in performance. In this work, nucleobases (NBs), constituents of DNA and RNA polymers, are investigated for integration into OLEDs. NB small molecules form excellent thin films by low-temperature evaporation, enabling seamless integration into vacuum deposited OLED fabrication. Thin film properties of adenine (A), guanine (G), cytosine (C), thymine (T), and uracil (U) are investigated. Next, their incorporation as electron-blocking (EBL) and hole-blocking layers (HBL) in phosphorescent OLEDs is explored. NBs affect OLED performance through charge transport control, following their electron affinity trend: G < A < C < T < U. G and A have lower electron affinity (1.8-2.2 eV), blocking electrons but allowing hole transport. C, T, and U have higher electron affinities (2.6-3.0 eV), transporting electrons and blocking hole transport. A-EBL-based OLEDs achieve current and external quantum efficiencies of 52 cd A(-1) and 14.3%, a ca. 50% performance increase over the baseline device with conventional EBL. The combination of enhanced performance, wide diversity of material properties, simplicity of use, and reduced cost indicate the promise of nucleobases for future OLED development.

  1. Management factors related to seroprevalences to bovine viral-diarrhoea virus, bovine-leukosis virus, Mycobacterium avium subspecies paratuberculosis, and Neospora caninum in dairy herds in the Canadian Maritimes.

    Science.gov (United States)

    Chi, Junwook; VanLeeuwen, John A; Weersink, Alfons; Keefe, Gregory P

    2002-09-10

    Bovine viral-diarrhoea (BVD), enzootic bovine leukosis (EBL), Johne's disease (JD), and neosporosis lower on-farm productivity, reduce export competitiveness, and increase consumer concerns regarding safety. Our purpose was to examine the relationship between 27 control practices and the estimated true seroprevalences for these four diseases for 2604 cattle in 90 dairy herds in the Maritimes provinces of Canada. Overall, 37.8, 20.4, 3.4, and 19.2% of all sampled cattle were truly exposed to the agents of BVD, EBL, JD, and neosporosis, respectively. The median within-herd true prevalences were 0, 9.3, 0, and 12.3%, respectively. Factor analysis reduced the 27 control practices to two highly correlated factors. Tobit-regression analyses determined that vaccination practices were associated with reduced prevalence of exposure for Bovine viral-diarrhoea and EBL. Also, farms that tended to purchase their dairy animals were associated with higher seroprevalence for Johnes' disease. Neither of these two factors was associated with the seroprevalence of Neospora caninum infection. The few routine biosecurity measures that were investigated in this study were generally not related to the seroprevalences of these farms.

  2. Engineering the Carrier Dynamics of InGaN Nanowire White Light-Emitting Diodes by Distributed p-AlGaN Electron Blocking Layers

    Science.gov (United States)

    Nguyen, Hieu Pham Trung; Djavid, Mehrdad; Woo, Steffi Y.; Liu, Xianhe; Connie, Ashfiqua T.; Sadaf, Sharif; Wang, Qi; Botton, Gianluigi A.; Shih, Ishiang; Mi, Zetian

    2015-01-01

    We report on the demonstration of a new type of axial nanowire LED heterostructures, with the use of self-organized InGaN/AlGaN dot-in-a-wire core-shell nanowire arrays. The large bandgap AlGaN shell is spontaneously formed on the sidewall of the nanowire during the growth of AlGaN barrier of the quantum dot active region. As such, nonradiative surface recombination, that dominates the carrier dynamics of conventional axial nanowire LED structures, can be largely eliminated, leading to significantly increased carrier lifetime from ~0.3 ns to 4.5 ns. The luminescence emission is also enhanced by orders of magnitude. Moreover, the p-doped AlGaN barrier layers can function as distributed electron blocking layers (EBLs), which is found to be more effective in reducing electron overflow, compared to the conventional AlGaN EBL. The device displays strong white-light emission, with a color rendering index of ~95. An output power of >5 mW is measured for a 1 mm × 1 mm device, which is more than 500 times stronger than the conventional InGaN axial nanowire LEDs without AlGaN distributed EBLs.

  3. Extragalactic background light absorption signal in the 0.26-10 TeV spectra of blazars

    CERN Document Server

    Vasilev, V

    1999-01-01

    Recent observations of the TeV gamma-ray spectra of the two closest active galactic nuclei (AGNs), Markarian 501 (Mrk 501) and Markarian 421 (Mrk 421), by the Whipple and HEGRA collaborations have stimulated efforts to estimate or limit the spectral energy density (SED) of extragalactic background light (EBL) which causes attenuation of TeV photons via pair-production when they travel cosmological distances. In spite of the lack of any distinct cutoff-like feature in the spectra of Mrk 501 and Mrk 421 (in the interval 0.26-10 TeV) which could clearly indicate the presence of such a photon absorption mechanism, we demonstrate that strong EBL attenuation signal (survival probability of 10 TeV photon (~10^{-2}) may still be present in the spectra of these AGNs. This attenuation could escape detection due to a special form of SED of EBL and unknown intrinsic spectra of these blazars. Here we show how the proposed and existing experiments, VERITAS, HESS, MAGIC, STACEE and CELESTE may be able to detect or severely ...

  4. Helium ion beam lithography (HIBL) using HafSOx as the resist

    Science.gov (United States)

    Luo, Feixiang; Manichev, Viacheslav; Li, Mengjun; Mitchson, Gavin; Yakshinskiy, Boris; Gustafsson, Torgny; Johnson, David; Garfunkel, Eric

    2016-03-01

    Helium ion beam lithography (HIBL) is a novel alternative lithographic technique with the capacity of fabricating highresolution and high-density features. Only limited research has been performed exploring HIBL to date. HafSOx (Hf(OH)4-2x-2y(O2)x(SO4)y·qH2O) is a negative-tone inorganic resist that is one of several candidate resist materials for extreme ultraviolet lithography (EUVL) and e-beam lithography (EBL), and has been demonstrated to show high resolution, moderate sensitivity and low line-edge roughness (LER) in both EUVL and EBL. To date, no ion beam lithography work on HafSOx has been reported. In this study, we tested HafSOx as an HIBL resist and achieved a high sensitivity compared with EBL with a turn-on dose D100 ~ 2-4 μC/cm2. We obtained sub-10 nm line widths with low LER. A simple Monte Carlo simulation suggests that ionizing excitation accounts for most of the incident He ions' energy loss.

  5. Integration of plant viruses in electron beam lithography nanostructures

    Science.gov (United States)

    Alonso, Jose M.; Ondarçuhu, Thierry; Bittner, Alexander M.

    2013-03-01

    Tobacco mosaic virus (TMV) is the textbook example of a virus, and also of a self-assembling nanoscale structure. This tubular RNA/protein architecture has also found applications as biotemplate for the synthesis of nanomaterials such as wires, as tubes, or as nanoparticle assemblies. Although TMV is, being a biological structure, quite resilient to environmental conditions (temperature, chemicals), it cannot be processed in electron beam lithography (eBL) fabrication, which is the most important and most versatile method of nanoscale structuring. Here we present adjusted eBL-compatible processes that allow the incorporation of TMV in nanostructures made of positive and negative tone eBL resists. The key steps are covering TMV by polymer resists, which are only heated to 50 °C, and development (selective dissolution) in carefully selected organic solvents. We demonstrate the post-lithography biochemical functionality of TMV by selective immunocoating of the viral particles, and the use of immobilized TMV as direct immunosensor. Our modified eBL process should be applicable to incorporate a wide range of sensitive materials in nanofabrication schemes.

  6. Fabrication of sub-10 nm planar nanotips for transport experiments of biomolecules

    Energy Technology Data Exchange (ETDEWEB)

    Visconti, P.; Maruccio, G.; D' Amone, E.; Della Torre, A.; Bramanti, A.; Cingolani, R.; Rinaldi, R

    2003-12-15

    Electron beam lithography (EBL) and lift-off process have been used to fabricate two- and three-terminal nano-devices consisting of metallic (Cr/Au, Ti/Au or Ti/Pt) arrow-shaped electrodes on Si/SiO{sub 2}, with tip separation between 100 and less than 10 nm. Standard EBL process allowed us to obtain nanotips with separation around 40 nm. In order to reduce the tip separation down to about 20 nm, before the EBL process, we used the defocused e-beam to brush the PMMA resist for a precise time (10-40 s). A further reduction of the tip gap (less than 10 nm) is obtained by Au electroplating deposition. The nanotips were electrically characterized by current-voltage (I-V) measurements in the range {+-}2 V. In a typical I-V measurement in air of an 'open-circuit' nanodevice, no significant current is observed (current range -10 - +10 pA, 'open circuit' resistance{approx}1 T{omega}) confirming the success of the technological process.

  7. Gamma rays from the quasar PKS 1441+25: story of an escape

    CERN Document Server

    Abeysekara, A U; Archer, A; Aune, T; Barnacka, A; Benbow, W; Bird, R; Biteau, J; Buckley, J H; Bugaev, V; Cardenzana, J V; Cerruti, M; Chen, X; Christiansen, J L; Ciupik, L; Connolly, M P; Coppi, P; Cui, W; Dickinson, H J; Dumm, J; Eisch, J D; Errando, M; Falcone, A; Feng, Q; Finley, J P; Fleischhack, H; Flinders, A; Fortin, P; Fortson, L; Furniss, A; Gillanders, G H; Griffin, S; Grube, J; Gyuk, G; Hütten, M; Håkansson, N; Hanna, D; Holder, J; Humensky, T B; Johnson, C A; Kaaret, P; Kar, P; Kelley-Hoskins, N; Khassen, Y; Kieda, D; Krause, M; Krennrich, F; Kumar, S; Lang, M J; Maier, G; McArthur, S; McCann, A; Meagher, K; Moriarty, P; Mukherjee, R; Nieto, D; de Bhróithe, A O'Faoláin; Ong, R A; Otte, A N; Park, N; Perkins, J S; Petrashyk, A; Pohl, M; Popkow, A; Pueschel, E; Quinn, J; Ragan, K; Ratliff, G; Reynolds, P T; Richards, G T; Roache, E; Rousselle, J; Santander, M; Sembroski, G H; Shahinyan, K; Smith, A W; Staszak, D; Telezhinsky, I; Todd, N W; Tucci, J V; Tyler, J; Vassiliev, V V; Vincent, S; Wakely, S P; Weiner, O M; Weinstein, A; Wilhelm, A; Williams, D A; Zitzer, B; Smith, P S; Holoien, T W -S; Prieto, J L; Kochanek, C S; Stanek, K Z; Shappee, B; Hovatta, T; Max-Moerbeck, W; Pearson, T J; Reeves, R A; Richards, J L; Readhead, A C S; Madejski, G M; Djorgovski, S G; Drake, A J; Graham, M J; Mahabal, A

    2015-01-01

    Outbursts from gamma-ray quasars provide insights on the relativistic jets of active galactic nuclei and constraints on the diffuse radiation fields that fill the Universe. The detection of significant emission above 100 GeV from a distant quasar would show that some of the radiated gamma rays escape pair-production interactions with low-energy photons, be it the extragalactic background light (EBL), or the radiation near the supermassive black hole lying at the jet's base. VERITAS detected gamma-ray emission up to 200 GeV from PKS 1441+25 (z=0.939) during April 2015, a period of high activity across all wavelengths. This observation of PKS 1441+25 suggests that the emission region is located thousands of Schwarzschild radii away from the black hole. The gamma-ray detection also sets a stringent upper limit on the near-ultraviolet to near-infrared EBL intensity, suggesting that galaxy surveys have resolved most, if not all, of the sources of the EBL at these wavelengths.

  8. Effects of electrical lesions of the medial preoptic area and the ventral pallidum on mate-dependent paternal behavior in mice.

    Science.gov (United States)

    Akther, Shirin; Fakhrul, Azam A K M; Higashida, Haruhiro

    2014-06-06

    In laboratory animals, less is known about the neural circuits that mediate paternal behavior than those that influence maternal behavior. In mice, we recently reported that when sires are separated with their mate dams from their pups, ultrasound and pheromonal signals from the dams can evoke and initiate maternal-like retrieval behavior in the sires upon reunion with the offspring; this is termed mate-dependent paternal care. We used electrolytic brain lesion (EBL) methods to identify the potential roles of the medial preoptic area (mPOA) and ventral pallidum (VP) regions in regulating paternal care, areas known to be critical for the expression of maternal behavior. Electrolytic lesions of the mPOA or VP disrupted mate-dependent paternal care; latencies to initiate pup retrieval, grooming and crouching were longer in the EBL-treated sires relative to the sham-operated mice. The number of grooming episodes and duration of crouching were also lower in sires with the EBL in both areas. These results indicate that the mPOA and VP regions are essential for mate-dependent paternal care in mice.

  9. Assessment of a complication risk score and study of complication profile in laparoscopic distal pancreatectomy.

    Science.gov (United States)

    Malleo, Giuseppe; Salvia, Roberto; Mascetta, Giuseppe; Esposito, Alessandro; Landoni, Luca; Casetti, Luca; Maggino, Laura; Bassi, Claudio; Butturini, Giovanni

    2014-11-01

    This study assessed the patient-specific risk for major postoperative morbidity in a series of 100 laparoscopic distal pancreatectomies (LDP). A previously established complication risk score (CRS), identifying body mass index (BMI), estimated blood loss (EBL), and pancreatic specimen length as determinants of postoperative morbidity were examined against the observed outcomes. In addition, multivariate analyses were performed to investigate risk factors specific to our study population. The postoperative morbidity rate was 49 %, major complication accounted for 12 %, and clinically relevant pancreatic fistulae (PF) were 13 %. The incidence of any complications, major complications, any PF, and clinically relevant PF did not vary appreciably when the CRS increased. The multivariate analysis indicated that male sex and an EBL ≥150 mL were independent predictors of major morbidity and clinically relevant PF. In conclusion, the previously published CRS based on pre- and intraoperative factors was not able to predict the postoperative risk in our population. This is probably because risk scores may not be able to adjust for the case-mix (heterogeneity in baseline patient characteristics). According to our data, men and patients with EBL ≥150 mL are more likely to develop major postoperative complications after LDP.

  10. Low level of selenium increases the efficacy of 24-epibrassinolide through altered physiological and biochemical traits of Brassica juncea plants.

    Science.gov (United States)

    Naz, Fatima Salva; Yusuf, Mohammad; Khan, Tanveer A; Fariduddin, Qazi; Ahmad, Aqil

    2015-10-15

    This study was conducted to provide an insight into the effect of Se (through soil) induced changes in Brassica juncea plants in the presence and absence of 24-epibrassinolide (EBL; foliar). The Se treatments showed dual response, 10 μM of Se significantly increased growth, water relations, photosynthetic attributes along with carbonic anhydrase activity whereas its higher concentrations proved inhibitory in concentration dependent manner. The follow-up application of EBL to the Se stressed plants improved growth, water relations, photosynthesis and simultaneously enhanced the various antioxidant enzymes viz. catalase, peroxidase and superoxide dismutase with the excess accumulation of proline. In addition to this, 10 μM Se increases the efficacy of 10(-8) M of EBL and both in combination showed maximum increase for the growth and photosynthetic traits of plants. On the other hand, the elevated level of antioxidant enzymes as well as proline could have conferred tolerance to the Se-stressed plants resulting in improved growth, water relations and photosynthesis.

  11. Diagnosing and treating Enquiry Based Learning fatigue in Graduate Entry Nursing students.

    Science.gov (United States)

    Stacey, Gemma; Wilson, Claire; Reddy, Helen; Palmer, Chris; Henderson, James; Little, Hannah; Bull, Heather

    2017-09-09

    The use of student directed study approaches such as Enquiry Based Learning (EBL) in the design and implementation of Graduate Entry Nursing Circular is well established. The rational relates to the maximisation of graduate attributes such as motivation to learn, the ability to identify, search and assimilate relevant literature and the desire to take ownership of the direction and pace of learning. Existing alongside this however, is the observation that students remain under confident in the application of knowledge to a clinical context and frustrated with learning approaches which do not appear directly related to improving their competence in this area. We suggest the result of this is a gradual disengagement and dissatisfaction the learning forum amongst students and faculty, which we have defined as EBL fatigue. The symptoms and consequences of EBL fatigue amongst students and faculty are discussed alongside strategies which we suggest may act as preventative measures in reducing the risk of a local epidemic. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Selected biochemical and oxidative stress parameters and ceruloplasmin as acute phase protein associated with bovine leukaemia virus infection in dairy cows

    Directory of Open Access Journals (Sweden)

    Akalın Pınar Peker

    2015-09-01

    Full Text Available The aim of this study was to determine the ceruloplasmin (Cp and vitamin C concentrations, the total antioxidant status (TAS, and selected biochemical parameters in dairy cows spontaneously infected with bovine leukaemia virus (BLV. Of the 27 cows included in the study, 18 animals were seropositive for enzootic bovine leukosis (EBL, whereas nine cows were seronegative and were used as controls. The serum aspartate aminotransferase (AST (P = 0.003 and Cp concentrations (P = 0.03 decreased (65.17 ± 5.03 and 7.70 ± 0.72 respectively in BLV-infected cows, as compared to healthy animals (100.67 ± 11.50 and 10.40 ± 0.70 respectively. A slight insignificant increase in alkaline phosphatase activity and unchanged levels of alanine aminotransferase, lactate dehydrogenase, calcium, magnesium, and TAS were demonstrated in EBL cows. As the TAS and vitamin C levels remained unchanged in EBL cows, it may be suggested that ruminants may compensate for the impaired oxidative/antioxidative balance. The results obtained also indicate that BLV may suppress AST and Cp synthesis or secretion in the liver through an unknown mechanism. The mechanism of action of BLV in hepatocytes, especially on AST and Cp, requires further investigation to elucidate the immune suppression caused by oncogenic retroviruses.

  13. Characterization of the Duffy-Binding-Like Domain of Plasmodium falciparum Blood-Stage Antigen 332

    Directory of Open Access Journals (Sweden)

    Sandra Nilsson

    2011-01-01

    Full Text Available Studies on Pf332, a major Plasmodium falciparum blood-stage antigen, have largely been hampered by the cross-reactive nature of antibodies generated against the molecule due to its high content of repeats, which are present in other malaria antigens. We previously reported the identification of a conserved domain in Pf332 with a high degree of similarity to the Duffy-binding-like (DBL domains of the erythrocyte-binding-like (EBL family. We here describe that antibodies towards Pf332-DBL are induced after repeated exposure to P. falciparum and that they are acquired early in life in areas of intense malaria transmission. Furthermore, a homology model of Pf332-DBL was found to be similar to the structure of the EBL-DBLs. Despite their similarities, antibodies towards Pf332-DBL did not display any cross-reactivity with EBL-proteins as demonstrated by immunofluorescence microscopy, Western blotting, and peptide microarray. Thus the DBL domain is an attractive region to use in further studies on the giant Pf332 molecule.

  14. Influence of electron-beam lithography exposure current level on the transport characteristics of graphene field effect transistors

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Sangwoo, E-mail: swk1230@utexas.edu; Movva, Hema C. P.; Sanne, Atresh; Rai, Amritesh; Banerjee, Sanjay K. [Microelectronics Research Center, The University of Texas at Austin, Austin, Texas 78758 (United States)

    2016-03-28

    Many factors have been identified to influence the electrical transport characteristics of graphene field-effect transistors. In this report, we examine the influence of the exposure current level used during electron beam lithography (EBL) for active region patterning. In the presence of a self-assembled hydrophobic residual layer generated by oxygen plasma etching covering the top surface of the graphene channel, we show that the use of low EBL current level results in higher mobility, lower residual carrier density, and charge neutrality point closer to 0 V, with reduced device-to-device variations. We show that this correlation originates from the resist heating dependent release of radicals from the resist material, near its interface with graphene, and its subsequent trapping by the hydrophobic polymer layer. Using a general model for resist heating, we calculate the difference in resist heating for different EBL current levels. We further corroborate our argument through control experiments, where radicals are either intentionally added or removed by other processes. We also utilize this finding to obtain mobilities in excess of 18 000 cm{sup 2}/V s on silicon dioxide substrates. We believe these results are applicable to other 2D materials such as transition metal dichalcogenides and nanoscale devices in general.

  15. Improving hole injection and carrier distribution in InGaN light-emitting diodes by removing the electron blocking layer and including a unique last quantum barrier

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Liwen, E-mail: lwcheng@yzu.edu.cn; Chen, Haitao; Wu, Shudong [College of Physics Science and Technology & Institute of Optoelectronic Technology, Yangzhou University, Yangzhou 225002 (China)

    2015-08-28

    The effects of removing the AlGaN electron blocking layer (EBL), and using a last quantum barrier (LQB) with a unique design in conventional blue InGaN light-emitting diodes (LEDs), were investigated through simulations. Compared with the conventional LED design that contained a GaN LQB and an AlGaN EBL, the LED that contained an AlGaN LQB with a graded-composition and no EBL exhibited enhanced optical performance and less efficiency droop. This effect was caused by an enhanced electron confinement and hole injection efficiency. Furthermore, when the AlGaN LQB was replaced with a triangular graded-composition, the performance improved further and the efficiency droop was lowered. The simulation results indicated that the enhanced hole injection efficiency and uniform distribution of carriers observed in the quantum wells were caused by the smoothing and thinning of the potential barrier for the holes. This allowed a greater number of holes to tunnel into the quantum wells from the p-type regions in the proposed LED structure.

  16. Build up and integration of the rocket-borne Cosmic Infrared Background ExpeRiment-2

    Science.gov (United States)

    Lanz, Alicia E.; Arai, Toshiaki; Battle, John; Bock, James; Cooray, Asantha R.; Hristov, Viktor; Kojima, Tomoya; Korngut, Phillip; Lee, Dae Hee; Mason, Peter; Matsumoto, Toshio; Matsuura, Shuji; Nguyen, Chi; Shirahata, Mai; Takahashi, Aoi; Tsumurai, Kohji; Wada, Takehiko; Wang, Shiang-Yu; Zemcov, Michael B.

    2017-01-01

    The Cosmic Infrared Background ExpeRiment, CIBER-2, is a near-infrared rocket-borne instrument designed to conduct comprehensive multi-band measurements of extragalactic background light anisotropy on arcsecond to degree angular scales. Recent measurements of the near-infrared Extragalactic Background Light (EBL) anisotropy find excess spatial power above the level predicted by known galaxy populations at large angular scales. CIBER-2 is designed to make measurements of the EBL anisotropy with the sensitivity, spectral range, and spectral resolution required to disentangle the contributions to the EBL from various sources throughout cosmic history.CIBER-2 consists of a 28.5 cm Cassegrain telescope assembly, imaging optics, and cryogenics mounted aboard a sounding rocket. Two dichroic beam-splitters spectrally subdivide the incident radiation into three optical paths, which are further subdivided in two wavelength bands per path, for a total of six observational wavelength bands that span the optical to the near-infrared and produce six 1.2 by 2.4 degree images recorded by three 2048 x 2048 HAWAII-2RG detector arrays. A small portion of each detector is also dedicated to absolute spectrophotometric imaging provided by a linear-variable filter. The instrument has several novel cryogenic mechanisms, a cryogenically-cooled pop-up baffle that extends during observations to provide radiative shielding and an electromagnetic cold shutter. We provide an overview of the instrument and current integration.

  17. GAMMA-RAYS FROM THE QUASAR PKS 1441+25: STORY OF AN ESCAPE

    Energy Technology Data Exchange (ETDEWEB)

    Abeysekara, A. U. [Department of Physics and Astronomy, University of Utah, Salt Lake City, UT 84112 (United States); Archambault, S. [Physics Department, McGill University, Montreal, QC H3A 2T8 (Canada); Archer, A.; Buckley, J. H.; Bugaev, V. [Department of Physics, Washington University, St. Louis, MO 63130 (United States); Aune, T. [Department of Physics and Astronomy, University of California, Los Angeles, CA 90095 (United States); Barnacka, A. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Benbow, W.; Cerruti, M. [Fred Lawrence Whipple Observatory, Harvard-Smithsonian Center for Astrophysics, Amado, AZ 85645 (United States); Bird, R. [School of Physics, University College Dublin, Belfield, Dublin 4 (Ireland); Biteau, J. [Santa Cruz Institute for Particle Physics and Department of Physics, University of California, Santa Cruz, CA 95064 (United States); Cardenzana, J. V. [Department of Physics and Astronomy, Iowa State University, Ames, IA 50011 (United States); Chen, X. [Institute of Physics and Astronomy, University of Potsdam, D-14476 Potsdam-Golm (Germany); Christiansen, J. L. [Physics Department, California Polytechnic State University, San Luis Obispo, CA 94307 (United States); Ciupik, L. [Astronomy Department, Adler Planetarium and Astronomy Museum, Chicago, IL 60605 (United States); Connolly, M. P. [School of Physics, National University of Ireland Galway, University Road, Galway (Ireland); Coppi, P. [Department of Astronomy, Yale University, New Haven, CT 06520-8101 (United States); Cui, W. [Department of Physics and Astronomy, Purdue University, West Lafayette, IN 47907 (United States); Dickinson, H. J.; Dumm, J., E-mail: matteo.cerruti@cfa.harvard.edu, E-mail: caajohns@ucsc.edu, E-mail: jbiteau@ucsc.edu, E-mail: biteau@ipno.in2p3.fr, E-mail: mcerruti@lpnhe.in2p3.fr, E-mail: mark.lang@nuigalway.ie [School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455 (United States); Collaboration: VERITAS; SPOL; ASAS-SN; OVRO; NuSTAR; CRTS; and others

    2015-12-20

    Outbursts from gamma-ray quasars provide insights on the relativistic jets of active galactic nuclei and constraints on the diffuse radiation fields that fill the universe. The detection of significant emission above 100 GeV from a distant quasar would show that some of the radiated gamma-rays escape pair-production interactions with low-energy photons, be it the extragalactic background light (EBL), or the radiation near the supermassive black hole lying at the jet’s base. VERITAS detected gamma-ray emission up to ∼200 GeV from PKS 1441+25 (z = 0.939) during 2015 April, a period of high activity across all wavelengths. This observation of PKS 1441+25 suggests that the emission region is located thousands of Schwarzschild radii away from the black hole. The gamma-ray detection also sets a stringent upper limit on the near-ultraviolet to near-infrared EBL intensity, suggesting that galaxy surveys have resolved most, if not all, of the sources of the EBL at these wavelengths.

  18. TeV GAMMA RAYS: OBSERVATIONS VERSUS EXPECTATIONS & THEORY

    Directory of Open Access Journals (Sweden)

    Frank Krennrich

    2013-12-01

    Full Text Available The scope of this paper is to discuss two important questions relevant for TeV γ-ray astronomy; the pursuit to reveal the origin of cosmic rays in our galaxy, and the opacity of the universe in γ-rays. The origin of cosmic rays stipulated the field of TeV astronomy in the first place, and led to the development of the atmospheric Cherenkov technique; significant progress has been made in the last decade through the detection of several supernova remnants, the primary suspects for harboring the acceleration sites of cosmic rays. TeV γ-rays propagate mostly unhindered through the galactic plane, making them excellent probes of processes in SNRs and other galactic sources. Key results related to the SNR origin of cosmic rays are discussed. TeV γ-ray spectra from extragalactic sources experience significant absorption when traversing cosmological distances. The opacity of the universe to γ-rays above 10 GeV progressively increases with energy and redshift; the reason lies in their pair production with ambient soft photons from the extragalactic background light (EBL. While this limits the γ-ray horizon, it offers the opportunity to gain information about cosmology, i.e. the EBL intensity, physical conditions in intergalactic space, and potentially new interaction processes. Results and implications pertaining to the EBL are given.

  19. Metal nanoparticles for thin film solar cells

    DEFF Research Database (Denmark)

    Gritti, Claudia

    and used for FTDT simulations, in order to identify the set of parameters (NPs size and array periodicity) which could show LSP resonance in the NIR range. Two techniques are here used to fabricate NPs: electron beam lithography (EBL), to deposit ordered arrays of gold and silver NPs, simple to be compared...... the solar cell structure (GaAs, SiO2, Si3N4, AZO/Cr), in order to investigate the LSP resonance and tune it to exploit it below the energy band gap of the semiconductor. EBL is a difficult technique when working by lift-off on critical size (20-50 nm) nanoparticles. The optimization of the process saw...... a change from ZEP resist to double layer of PMMA and always requires preliminary exposure dose-tests and final particular attention for lift-off step. EBL resulted to be more suitable for silver NPs, since the deposition of gold (on top of an adhesion thin titanium layer) leads to a variation and non...

  20. Comparative Study on Flexural Strengthening of RC Beams using CFRP Laminate by Different Techniques

    Science.gov (United States)

    Jeevan, N.; Jagannatha Reddy, H. N.

    2017-08-01

    This paper presents a detailed study on flexural behaviour of RC beams strengthened using Carbon Fiber Reinforced Polymer (CFRP) laminate. A detailed study was made on strengthened beam using Externally Bonded Laminate (EBL) and Internally Bonded Laminate (IBL) techniques. In IBL technique the laminate is sandwiched between the layers of epoxy mounted on the cover portion by the groove. The beams were designed as under-reinforced section. Totally six beams were casted, out of this two beams were control beams. Strengthened beams were divided into two sets (IBL and EBL) of two beams each. The main aim of this work is to delay the debonding failure in order to enhance the ultimate load carrying capacity for strengthened beams. Four-point bending flexural tests were conducted on specimens up to failure. The experimental results illustrate that, the strengthened beams significantly increases the cracking, working and ultimate load when compared with control beams. IBL technique shows the significant increase in the debonding strain by delaying the beam from debonding failure which in turn enhances the ultimate load by almost 73% compared with control beam and 39% with EBL technique. All the deflection values from the experiments are within the limit of codal provisions. The IBL technique was emerged as the better strengthening technique, which increases almost 41% of working load (Pw) compared with strengthening codes.

  1. How gravitational lensing helps γ-ray photons avoid γ – γ absorption

    Energy Technology Data Exchange (ETDEWEB)

    Barnacka, Anna [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Böttcher, Markus; Sushch, Iurii, E-mail: abarnacka@cfa.harvard.edu, E-mail: Markus.Bottcher@nwu.ac.za [Centre for Space Research, North-West University, Potchefstroom, 2520 (South Africa)

    2014-08-01

    We investigate potential γ – γ absorption of γ-ray emission from blazars arising from inhomogeneities along the line of sight, beyond the diffuse Extragalactic Background Light (EBL). As plausible sources of excess γ – γ opacity, we consider (1) foreground galaxies, including cases in which this configuration leads to strong gravitational lensing, (2) individual stars within these foreground galaxies, and (3) individual stars within our own galaxy, which may act as lenses for microlensing events. We found that intervening galaxies close to the line of sight are unlikely to lead to significant excess γ – γ absorption. This opens up the prospect of detecting lensed gamma-ray blazars at energies above 10 GeV with their gamma-ray spectra effectively only affected by the EBL. The most luminous stars located either in intervening galaxies or in our galaxy provide an environment in which these gamma-rays could, in principle, be significantly absorbed. However, despite a large microlensing probability due to stars located in intervening galaxies, γ-rays avoid absorption by being deflected by the gravitational potentials of such intervening stars to projected distances ({sup i}mpact parameters{sup )} where the resulting γ – γ opacities are negligible. Thus, neither of the intervening excess photon fields considered here, provide a substantial source of excess γ – γ opacity beyond the EBL, even in the case of very close alignments between the background blazar and a foreground star or galaxy.

  2. Suppressing efficiency droop using graded AlGaN/InGaN superlattice electron blocking layer for InGaN-based light-emitting diodes

    Science.gov (United States)

    Wang, C. K.; Hung, K. C.; Chiou, Y. Z.; Jheng, J. S.; Chang, S. P.; Chang, S. J.

    2017-06-01

    In this study, the numerical simulations with graded p-AlxGa1-xN/InyGa1-yN shortperiod superlattice (SPS) electron blocking layer (EBL) of blue InGaN/GaN light-emitting diodes (LEDs) have been investigated by the Advance Physical Model of Semiconductor Devices (APSYS) program. The simulation results show that the LEDs with graded p-AlxGa1-xN/InyGa1-yN SPS EBL exhibit better performances of internal quantum efficiency (IQE) and efficiency droop than those of conventional p-AlGaN/GaN SPS EBL. This is attributed to higher and lower effective potential barrier heights created in the conduction and valence band for electron and hole, respectively. The electron overflow effect can be effectively suppressed and the hole injection ability can also be remarkably enhanced. Therefore, the simulation results exhibit a significant increment in the IQE and the ratio of efficiency droop of the LEDs can be obviously reduced from 17.2% to 4.7%.

  3. A rapid and sensitive diagnosis of bovine leukaemia virus infection using the nested shuttle polymerase chain reaction Diagnóstico rápido e sensível da infecção com o vírus da Leucemia Bovina através de Shuttle Nested Polymerase Chain Reaction

    Directory of Open Access Journals (Sweden)

    Ester T. González

    1999-04-01

    Full Text Available Bovine leukaemia virus (BLV is the causative agent of enzootic bovine leukosis (EBL. In Argentina, where a program to eradicate EBL has been introduced, sensitive and reliable diagnosis has attained high priority. Although the importance of the agar gel immunodiffusion test remains unchanged for routine work, an additional diagnostic technique is necessary to confirm cases of sera with equivocal results or of calves carrying maternal antibodies.Utilizing a nested shuttle polymerase chain reaction, the proviral DNA was detected from cows experimentally infected with as little as 5 ml of whole blood from BLV seropositive cows that were nonetheless normal in haematological terms. It proved to be a very sensitive technique, since it rapidly revealed the presence of the provirus, frequently at 2 weeks postinoculation and using a two-round procedure of nested PCR taking only 3 hours. Additionally, the primers used flanked a portion of the viral genome often employed to differentiate BLV type applying BamHI digestion. It is concluded that this method might offer a highly promising diagnostic tool for BLV infection.O Vírus da leucemia bovina (BLV é o agente causal da Leucose Enzoótica Bovina (EBL. Na Argentina, iniciou-se um programa de erradicação da EBL. Neste estágio, é prioritário possuir uma ferramenta de diagnóstico confiável. Embora seja indiscutível a importância do teste de agar gel imunodifusão, empregado rotineiramente no diagnóstico serológico da EBL, faz-se necessária uma técnica de diagnóstico adicional capaz de confirmar os resultados duvidosos. Foi possivel detectar ADN proviral aplicando Nested-PCR em novilhos experimentalmente infectados com pequenas doses de sangue total (5ml obtidas de um bovino BLV soropositivo. Esta técnica, cujo procedimento leva 3 horas, demonstrou ser muito sensível, uma vez que foi capaz de detectar a presença do provirus duas semanas após a inoculação. Os primers utilizados são os que

  4. 吉妮IUD与宫型IUD的临床对比

    Institute of Scientific and Technical Information of China (English)

    张丽丽; 李玉香

    2002-01-01

    宫内节育器(IUD)避孕法已有80余年历史, 是一种简便、安全、长效的节育措施. 根据1994年WHO年度报告, 全世界妇女应用IUD者占各种节育措施的21%, 中国则占38%左右, IUD在我国得到了广泛应用. 1986年, 我国引进由比利时医生Dirk Wildemeersch发明的一种新型GyneFix In IUD, 即吉妮IUD. 我院3年前开始临床应用, 效果满意, 现与常用的宫型IUD对比, 分析如下.

  5. Burocratización y racionalización en Max Weber a la luz de las interpretaciones actuales de su obra

    Directory of Open Access Journals (Sweden)

    Alexis Emanuel Gros

    2015-03-01

    Full Text Available Este trabajo se propone presentar de forma sucinta y sistemática la teoría de la burocracia de Max Weber y problematizar el rol que esta juega en sus reflexiones sobre el proceso de racionalización occidental (okzidentale Rationalisierung. Para ello, se analizan textos centrales del autor como Wirtschaft und Gesellschaft, Politik als Beruf y Die protestantische Ethik und der "Geist“ des Kapitalismus, entre otros. La exposición se guía en las más recientes interpretaciones germanoparlantes de la obra weberiana, a saber: las de Dirk Kaesler, Hans-Peter Müller, Uwe Barrelmeyer y Volker Kruse; y Harmut Rosa, David Strecker y Andreas Kottmann.

  6. R & D PROJECTS ARTICULATING SCIENTIFIC SYSTEM WITH ENTREPRENEUR SECTOR, AN ANALYSIS FROM THE DISTANCE COGNITIVA APPROACH

    Directory of Open Access Journals (Sweden)

    Álvarez, Francisco José

    2016-12-01

    Full Text Available This paper aims to study the interaction between universities and nearby firms from the research and development projects executed from the School of Engineering of the National University of Mar del Plata, analyzing the characteristics of companies linked contractually. The working hypothesis proposes to explain, through the concept of "cognitive distance" (Boschma, 2005; Dirk Fornahl et al., 2011, the competitive advantage presented by medium and large companies from mature sectors and small companies from technological sectors, to engage with the scientific and technological institutions. The results indicate that the company is contractually associated with the School of Engineering have demanded further developments of technological innovation, and reduced demand for services. While the origin of the application responds to a pattern adjusted to the proposed hypothesis.

  7. On the Eclipse of Thales, Cycles and Probabilities

    CERN Document Server

    Querejeta, Miguel

    2013-01-01

    According to classical tradition, Thales of Miletus predicted the total solar eclipse that took place on 28 May 585 BCE. Even if some authors have flatly denied the possibility of such a prediction, others have struggled to find cycles which would justify the achievement of the philosopher. Some of the proposed cycles have already been refuted, but two of them, namely those of Willy Hartner and Dirk Couprie, remain unchallenged. This paper presents some important objections to these two possibilities, based on the fact that these authors do not list all the eclipses potentially visible by their criteria. In addition, any explanation based on cycles will need to face the complex problem of visibility (smallest observable eclipse, weather...). The present article also includes a statistical study on the predictability of solar eclipses for a variety of periods, similar to that performed by Willy Hartner for lunar eclipses, resulting in lower probabilities in the solar case (and percentages depend on the chosen ...

  8. Kenteoretiese besinning oor teologiebeoefening aan die Teologiese Skool van Potchefstroom die afgelope twintig jaar

    Directory of Open Access Journals (Sweden)

    G. Snyman

    1992-06-01

    Full Text Available In commemoration of the death a hundred years ago of Dirk Postma, the founding father of the Gereformeerde Kerke in South Africa, this article focuses on the theological creativity of the past twenty years at the Theological School in Potchefstroom. Theological creativity in the GKSA should be viewed in the light of a fear of humanism, horizontalism and secularism. In the churches' zealousness to treat the Bible as the Word of God, in order to be able to say 'Thus says the Lord God’, the need to reflect on the recipients' epistemological presuppositions is not felt. Consequently, Neoplatonism, Positivism and Naive Realism found their way into the theological activity of the TSP. A lack of such reflection on these epistemological presuppositions creates the possibility of projecting them back into the Bible and then investing them with revelational authority.

  9. 达拉斯公敌Kenyon Martin

    Institute of Scientific and Technical Information of China (English)

    Husky

    2009-01-01

    过去有多次与其他球员起口角、发生冲突不良纪录的马丁(Kenyon Martin),今年季后赛又出事了,而且还惹毛了一大票人。高中时曾经是达拉斯知名学生运动员的马丁,这次季后赛第二轮碰到小牛队,一点也没放水,照样依着他往常的侵略性肌肉打法去逞凶斗狠,被他防守的诺威兹基(Dirk Nowitzki)在对抗时明显吃了不少亏,让达拉斯的球迷们都气得牙痒痒的。

  10. Notice: PSPB articles by authors with retracted articles at PSPB or other journals: Stapel, Smeesters, and Sanna.

    Science.gov (United States)

    Funder, David

    2014-01-01

    Numerous articles by the social psychologists Diederick Stapel, Dirk Smeesters, and Lawrence Sanna have been retracted in several different journals. The present notice reports the results of an investigation into papers authored or coauthored by these individuals, and published in Personality and Social Psychology Bulletin, that have not been retracted. The status of these papers range from data confirmed as legitimate by coauthors to, in many cases, being unknown as to their legitimacy. Given the lack of information in the latter cases, there is insufficient basis to recommend retraction at this time. Researchers using the results of these papers in their own work are advised to take the information reported in this notice into account.

  11. Regulation of KCNQ/Kv7 family voltage-gated K(+) channels by lipids.

    Science.gov (United States)

    Taylor, Keenan C; Sanders, Charles R

    2017-04-01

    Many years of studies have established that lipids can impact membrane protein structure and function through bulk membrane effects, by direct but transient annular interactions with the bilayer-exposed surface of protein transmembrane domains, and by specific binding to protein sites. Here, we focus on how phosphatidylinositol 4,5-bisphosphate (PIP2) and polyunsaturated fatty acids (PUFAs) impact ion channel function and how the structural details of the interactions of these lipids with ion channels are beginning to emerge. We focus on the Kv7 (KCNQ) subfamily of voltage-gated K(+) channels, which are regulated by both PIP2 and PUFAs and play a variety of important roles in human health and disease. This article is part of a Special Issue entitled: Lipid order/lipid defects and lipid-control of protein activity edited by Dirk Schneider.

  12. Leptospira Species in Feral Cats and Black Rats from Western Australia and Christmas Island.

    Science.gov (United States)

    Dybing, Narelle A; Jacobson, Caroline; Irwin, Peter; Algar, David; Adams, Peter J

    2017-05-01

    Leptospirosis is a neglected, re-emerging bacterial disease with both zoonotic and conservation implications. Rats and livestock are considered the usual sources of human infection, but all mammalian species are capable of carrying Leptospira spp. and transmitting pathogenic leptospires in their urine, and uncertainty remains about the ecology and transmission dynamics of Leptospira in different regions. In light of a recent case of human leptospirosis on tropical Christmas Island, this study aimed to investigate the role of introduced animals (feral cats and black rats) as carriers of pathogenic Leptospira spp. on Christmas Island and to compare this with two different climatic regions of Western Australia (one island and one mainland). Kidney samples were collected from black rats (n = 68) and feral cats (n = 59) from Christmas Island, as well as feral cats from Dirk Hartog Island (n = 23) and southwest Western Australia (n = 59). Molecular (PCR) screening detected pathogenic leptospires in 42.4% (95% confidence interval 29.6-55.9) of cats and 2.9% (0.4-10.2) of rats from Christmas Island. Sequencing of cat- and rat-positive samples from Christmas Island showed 100% similarity for Leptospira interrogans. Pathogenic leptospires were not detected in cats from Dirk Hartog Island or southwest Western Australia. These findings were consistent with previous reports of higher Leptospira spp. prevalence in tropical regions compared with arid and temperate regions. Despite the abundance of black rats on Christmas Island, feral cats appear to be the more important reservoir species for the persistence of pathogenic L. interrogans on the island. This research highlights the importance of disease surveillance and feral animal management to effectively control potential disease transmission.

  13. Parasitosis intestinal en monos capuchinos cariblancos Cebus capucinus (Primates: Cebidae de un área protegida en la provincia de Limón, noreste de Costa Rica

    Directory of Open Access Journals (Sweden)

    Misael Chinchilla

    2010-12-01

    Full Text Available La deforestación de bosques tropicales está amenazando la biodiversidad de las especies de primates y su estado de salud, dependiente de un lugar ecológicamente equilibrado. Con el fin de evaluar esta relación, se analizó la presencia de parásitos en los intestinos de esta especie. El estudio se realizó en la Estación Biológica La Suerte (EBLS, Limón, Costa Rica. El grupo de monos capuchinos cariblancos (Cebus capucinus fue observado entre marzo y diciembre de 2006. Se recolectaron 75 muestras de heces a las que se les identificó las plantas ingeridas, y se procesaron en el laboratorio para evaluar la prevalencia de parásitos. Moraceae fue la familia de plantas más reportada. Strongyloides spp. y acantocéfalos fueron los más comunes. La distribución positiva de las mismas fue similar independientemente del sexo y la edad. Microsporidios se reportaron mayoritariamente en heces asociadas con la familia Piperaceae. Fue encontrada una baja existencia de éstos parásitos en muestras asociadas con Myrtaceae en cuyo género Psidium, se han reportado compuestos activos antiparasitarios. La aparición de parásitos fue relativamente mayor en la EBLS, comparado con muestras de otras regiones más secas de Costa Rica. Por lo tanto, esa expresión parasitaria puede deberse al hecho de ser la EBLS una selva lluviosa, además de estar rodeada por zonas con actividades antrópicas. Se sugiere incrementar las investigaciones de parasitología de campo en primates neotropicales con el fin de entender plenamente las relaciones parásitos-hospederos, para en un largo plazo poder comprender los ecosistemas donde conviven, y en consecuencia, preservar la diversidad biológica.Intestinal parasites in white-faced capuchin monkeys Cebus capucinus Primates: Cebidae inhabiting a protected area in the Limón province of Northeastern Costa Rica. Deforestation of tropical forests is threatening monkey biodiversity and their health status, dependent of an

  14. Surgical and clinical safety and effectiveness of robot-assisted laparoscopic hysterectomy compared to conventional laparoscopy and laparotomy for cervical cancer: A systematic review and meta-analysis.

    Science.gov (United States)

    Park, D A; Yun, J E; Kim, S W; Lee, S H

    2017-06-01

    This study aimed to evaluate the surgical safety and clinical effectiveness of RH versus LH and laparotomy for cervical cancer. We searched Ovid-Medline, Ovid-EMBASE, and the Cochrane library through May 2015, and checked references of relevant studies. We selected the comparative studies reported the surgical safety (overall; peri-operative; and post-operative complications; death within 30 days; and specific morbidities), and clinical effectiveness (survival; recurrence; length of stay [LOS]; estimated blood loss [EBL]; operative time [OT]) and patient-reported outcomes. Fifteen studies comparing RH with OH and 11 comparing RH with LH were identified. No significant differences were found in survival outcomes. The LOS was shorter and transfusion rate was lower with RH compared to OH or LH. EBL was significantly reduced with RH compared to OH. Compared to OH, overall complications, urinary infection, wound infection, and fever were significantly less frequent with RH. The overall, peri-operative, and post-operative complications were similar in other comparisons. Several patient-reported outcomes were improved with RH, though each outcome was reported in only one study. RH appears to have a positive effect in reducing overall complications, individual adverse events including wound infection, fever, urinary tract infection, transfusion, LOS, EBL, and time to diet than OH for cervical cancer patients. Compared to LH, the current evidence is not enough to clearly determine its clinical safety and effectiveness. Further rigorous prospective studies with long-term follow-up that overcome the many limitations of the current evidence are needed. Copyright © 2016 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

  15. Improvement of Electron Beam Lithography modeling for overdose exposures by using Dill transformation

    Science.gov (United States)

    Abaidi, Mohamed; Saib, Mohamed; Tortai, Jean-Hervé; Schiavone, Patrick

    2016-09-01

    In Electron Beam Lithography (EBL), the modeling of the Proximity Effects (PE) is the key to successfully print patterns of different size and density at the desired dimension. Although current PE models are increasingly efficient for nominal process conditions, they do not allow covering a broad exposure dose range, which would be interesting for extending the process window, for instance. This paper shows how to improve the accuracy of the dimension estimations of overexposed patterns by EBL by adding a new term to the existing compact model. This advanced compact model was inspired by the chemical mechanisms that activate the acid generator embedded in the resist during the EBL exposure. Most of the existing compact models use the electronic Aerial Image (E AEI) calculated by the convolution product of the patterns geometry with a Point Spread Function (PSF) and extract pattern contours using a threshold value to model the non-linear resist behavior [1]. Here the patterns contours are simulated using an Acid Aerial Image (A AEI) calculated from the initial E_AEI complemented by the Dill transformation [1]. A strong impact is expected at high exposure doses but no changes should occur on patterns exposed close to their nominal dose. The modeling and calibration capabilities of Inscale® software was used to validate the new model with experimental measurements. Calibration and simulations obtained with both standard model and advanced model were compared on a test design. First it shows that after calibration the PSF of the two models are similar, meaning that physics is consistent for both models. The new advanced model allows maintaining the accuracy at nominal dose but increases the overall accuracy by 62 % for a process window of dose with latitude extended up to 20%.

  16. Robot-assisted laparoscopic hysterectomy vs traditional laparoscopic hysterectomy: five metaanalyses.

    Science.gov (United States)

    Scandola, Michele; Grespan, Lorenzo; Vicentini, Marco; Fiorini, Paolo

    2011-01-01

    To assess differences between laparoscopic hysterectomy performed with or without robot-assistance, we performed metaanalyses of 5 key indices strongly associated with societal and hospital costs, patient safety, and intervention quality. The 5 indexes included estimated blood loss (EBL), operative time, number of conversions to laparotomy, hospital length of stay (LOS), and number of postoperative complications. A search of PubMed, Medline, Embase, and Science citation index online databases yielded a total of 605 studies. After a systematic review, we proceeded with meta-analysis of 14 articles for EBL, with a summary effect of -0.61 (95% confidence interval [CI], -42.42 to 46.20); 20 for operative time, with a summary effect of 0.66 (95% CI, -15.72 to 17.04); 17 for LOS, with a summary effect of -0.43 (95% CI, -0.68 to -0.17); 15 for conversion to laparotomy (odds ratio, 0.50; 95% CI, 0.31 to 0.79 with a random model); and 14 for postoperative complications (odds ratio, 0.69; 95% CI, 0.43 to 1.09 with a random model). In conclusion, compared with traditional laparoscopic hysterectomy, robot-assisted laparoscopic hysterectomy was associated with shorter LOS and fewer postoperative complications and conversions to laparotomy; there were no differences in EBL and operative time. These results confirm that robot-assisted laparoscopy has less deletorious effect on hospital, society, and patient stress and leads to better intervention quality. Copyright © 2011 AAGL. Published by Elsevier Inc. All rights reserved.

  17. [Intestinal parasites in white-faced capuchin monkeys Cebus capucinus (Primates: Cebidae) inhabiting a protected area in the Limón province of Northeastern Costa Rica].

    Science.gov (United States)

    Chinchilla, Misael; Urbani, Bernardo; Valerio, Idalia; Vanegas, Juan Carlos

    2010-12-01

    Deforestation of tropical forests is threatening monkey biodiversity and their health status, dependent of an ecologically undisturbed area. To asses this relationship, we analyzed parasite occurrence in their intestines. The study was conducted at the Estación Biológica La Suerte (EBLS), Limón, Costa Rica. The group of white-faced capuchin monkeys (Cebus capucinus) was observed between March and December of 2006. A total of 75 feces samples were obtained. Once a sample was collected, the eaten plant type was identified to family and species level, and feces were processed in the laboratory to determine parasite incidence. Results showed that Moraceae was the most represented family in the samples. Among parasites, Strongyloides spp. and Acanthocephala were the most common. Positive prevalence of parasites was found similar and independent of sex and age of capuchin individuals. Microsporids were mainly reported in feces associated with Piperaceae. A low presence of these parasites was found in samples associated with Myrtaceae, with possible anti-parasite active components. The occurrence of parasites was relatively high in EBLS, when compared to other regions in Costa Rica. The higher occurrence of parasites observed in capuchins at EBLS may be due to the fact that this rain forest is surrounded by areas affected by human activities. We suggest the promotion of research in neotropical primates parasitology, for a better comprehension of the parasite-host relationship, and in a long term, being able to understand the ecosystems where they coexist, and consequently, preserve the biodiversity of the whole region.

  18. Investigation of some hematological and blood biochemical parameters in cattle spontaneously infected with bovine leukosis virus

    Directory of Open Access Journals (Sweden)

    Sandev Nikolay

    2013-09-01

    Full Text Available The aim of the present study was to follow out the alterations in some haematological and blood biochemical parameters in cattle spontaneously infected with enzootic bovine leukosis virus with regard to the invivodifferentiation of bovine leukosis stages. The experiment included 76 cows at various ages and body weight. Serological leukosis tests were done by agar-gel immunodiffusion test with a commercial kit of Synbiotiсs (France, containing standardised gp 51 antigen and positive serum approved by the EU. On the basis of haematological results, the cows were divided into three groups: first group – EBL-seropositive with normal haemogramme; second group – EBL seropositive with altered haemogramme and third group – controls. In cows from the first and the second group, a statistically significantly increased blood cell counts was established compared to healthy controls. The total WBC were increased in the second group (leukocytosis up to 33.21×109/l vs reference range of 5-10×109/l as well as lymphocyte percentages (lymphocytosis – 81.89% (reference 40–63%. A reduction in the proportion of neutrophils to 12.78% (relative neutropenia vs the reference range of 22-49% and monocytes (monocytopenia to 1.78% (reference range 2–6% was observed. A statistically significant reduction in Ca concentrations (4.41 mg/dl and higher inorganic phosphate levels (5.28 mg/dl were established in cows from the second group. Also, ASAT activity was considerably lower – 47.03 U/l, while alkaline phosphatase increased slightly within the reference range up to 167.68 U/l and 165.81 U/l in groups one and two, respectively. The present haematological and whole blood/serum biochemical results in cows spontaneously infected with EBL virus could be used as prognostic markers of the course of the disease, to distinguish the stages of infection with regard to alive diagnostics.

  19. Risk factors associated with within-herd transmission of bovine leukemia virus on dairy farms in Japan

    Directory of Open Access Journals (Sweden)

    Konishi Misako

    2010-01-01

    Full Text Available Abstract Background Although several attempts have been made to control enzootic bovine leukosis (EBL at the local level, a nationwide control program has not been implemented in Japan, except for passive surveillance. Effective control of EBL requires that the transmission routes of bovine leukemia virus (BLV infection should be identified and intercepted based on scientific evidence. In this cross-sectional study, we examined the risk factors associated with within-herd transmission of BLV on infected dairy farms in Japan. Blood samples taken from 30 randomly selected adult cows at each of 139 dairy farms were tested by enzyme-linked immunosorbent assay (ELISA. Information on herd management was collected using a structured questionnaire. Results Infected farms were defined as those with more than one ELISA-positive animal and accounted for 110 (79.1% of the 139 farms in the study. Completed questionnaires obtained from 90 of these 110 farms were used for statistical analysis. Seroprevalence, which was defined as the proportions of animals that tested positive out of all animals tested on the farm, was 17.1%, 48.1%, and 68.5% for the 25th, 50th, and 75th percentiles, respectively. A mixed logistic regression analysis implicated a loose housing system, dehorning, and a large number of horseflies in summer as risk factors (coefficient = 0.71, 1.11, and 0.82; p = 0.03, Conclusion Control of EBL in infected dairy farms in Japan will be improved by focusing particularly on these risk and protective factors.

  20. L233P mutation of the Tax protein strongly correlated with leukemogenicity of bovine leukemia virus.

    Science.gov (United States)

    Inoue, Emi; Matsumura, Keiko; Soma, Norihiko; Hirasawa, Shintaro; Wakimoto, Mayuko; Arakaki, Yoshihiro; Yoshida, Takashi; Osawa, Yoshiaki; Okazaki, Katsunori

    2013-12-27

    The bovine leukemia virus (BLV) Tax protein is believed to play a crucial role in leukemogenesis by the virus. BLV usually causes asymptomatic infections in cattle, but only one-third develop persistent lymphocytosis that rarely progress after a long incubation period to lymphoid tumors, namely enzootic bovine leucosis (EBL). In the present study, we demonstrated that the BLV tax genes could be divided into two alleles and developed multiplex PCR detecting an L233P mutation of the Tax protein. Then, in order to define the relationship between the Tax protein and leukemogenicity, we examined 360 tumor samples randomly collected from dairy or breeding cattle in Japan, of which Tax proteins were categorized, for age at the time of diagnosis of EBL. The ages of 288 animals (80.0%) associated with L233-Tax and those of 70 animals (19.4%) with P233-Tax individually followed log-normal distributions. Only the two earliest cases (0.6%) with L233-Tax disobeyed the log-normal distribution. These findings suggest that the animals affected by EBL were infected with the virus at a particular point in life, probably less than a few months after birth. Median age of those with P233-Tax was 22 months older than that with L233-Tax and geometric means exhibited a significant difference (PTax protein infect older cattle. Here, we conclude that BLV could be divided into two categories on the basis of amino acid at position 233 of the Tax protein, which strongly correlated with leukemogenicity.

  1. Nanohole and dot patterning processes on quartz substrate by R-θ electron beam lithography and nanoimprinting

    Science.gov (United States)

    Watanabe, Tsuyoshi; Taniguchi, Kazutake; Suzuki, Kouta; Iyama, Hiromasa; Kishimoto, Shuji; Sato, Takashi; Kobayashi, Hideo

    2016-06-01

    Fine hole and dot patterns with bit pitches (bp’s) of less than 40 nm were fabricated in the circular band area of a quartz substrate by R-θ electron beam lithography (EBL), reactive ion etching (RIE), and nanoimprinting. These patterning processes were studied to obtain minimum pitch sizes of hole and dot patterns without pattern collapse. The patterning on the circular band was aimed to apply these patterning processes to future high-density bit-patterned media (BPM) for hard disk drive (HDD) and permanent memory for the long life archiving of digital data. In hole patterning, a minimum-22-nm-bp and 8.2-nm-diameter pattern (1.3 Tbit/in.2) was obtained on a quartz substrate by optimizing the R-θ EBL and RIE processes. Dot patterns were replicated on another quartz substrate by nanoimprinting using a hole-patterned quartz substrate as a master mold followed by RIE. In dot patterning, a minimum-30-nm-bp and 18.5-nm-diameter pattern (0.7 Tbit/in.2) was obtained by introducing new descum conditions. It was observed that the minimum bp of successful patterning increased as the fabrication process proceeded, i.e., from 20 nm bp in the first EBL process to 30 nm bp in the last quartz dot patterning process. From the measured diameters of the patterns, it was revealed that pattern collapse was apt to occur when the value of average diameter plus 3 sigma of diameter was close to the bp. It was suggested that multiple fabrication processes caused the degradation of pattern quality; therefore, hole patterning is more suitable than dot patterning for future applications owing to the lower quality degradation by its simple fabrication process.

  2. Comparison of polymethylmethacrylate versus expandable cage in anterior vertebral column reconstruction after posterior extracavitary corpectomy in lumbar and thoraco-lumbar metastatic spine tumors.

    Science.gov (United States)

    Eleraky, Mohammed; Papanastassiou, Ioannis; Tran, Nam D; Dakwar, Elias; Vrionis, Frank D

    2011-08-01

    Single-stage posterior corpectomy for the management of spinal tumors has been well described. Anterior column reconstruction has been accomplished using polymethylmethacrylate (PMMA) or expandable cages (EC). The aim of this retrospective study was to compare PMMA versus ECs in anterior vertebral column reconstruction after posterior corpectomy for tumors in the lumbar and thoracolumbar spine. Between 2006 and 2009 we identified 32 patients that underwent a single-stage posterior extracavitary tumor resection and anterior reconstruction, 16 with PMMA and 16 with EC. There were no baseline differences in regards to age (mean: 58.2 years) or performance status. Differences between groups in terms of survival, estimated blood loss (EBL), kyphosis reduction (decrease in Cobb's angle), pain, functional outcomes, and performance status were evaluated. Mean overall survival and EBL were 17 months and 1165 ml, respectively. No differences were noted between the study groups in regards to survival (p = 0.5) or EBL (p = 0.8). There was a trend for better Kyphosis reduction in favor of the EC group (10.04 vs. 5.45, p = 0.16). No difference in performance status or VAS improvements was observed (p > 0.05). Seven patients had complications that led to reoperation (5 infections). PMMA or ECs are viable options for reconstruction of the anterior vertebral column following tumor resection and corpectomy. Both approaches allow for correction of the kyphotic deformity, and stabilization of the anterior vertebral column with similar functional and performance status outcomes in the lumbar and thoracolumbar area.

  3. Parasitosis intestinal en monos capuchinos cariblancos Cebus capucinus (Primates: Cebidae de un área protegida en la provincia de Limón, noreste de Costa Rica

    Directory of Open Access Journals (Sweden)

    Misael Chinchilla

    2010-12-01

    Full Text Available La deforestación de bosques tropicales está amenazando la biodiversidad de las especies de primates y su estado de salud, dependiente de un lugar ecológicamente equilibrado. Con el fin de evaluar esta relación, se analizó la presencia de parásitos en los intestinos de esta especie. El estudio se realizó en la Estación Biológica La Suerte (EBLS, Limón, Costa Rica. El grupo de monos capuchinos cariblancos (Cebus capucinus fue observado entre marzo y diciembre de 2006. Se recolectaron 75 muestras de heces a las que se les identificó las plantas ingeridas, y se procesaron en el laboratorio para evaluar la prevalencia de parásitos. Moraceae fue la familia de plantas más reportada. Strongyloides spp. y acantocéfalos fueron los más comunes. La distribución positiva de las mismas fue similar independientemente del sexo y la edad. Microsporidios se reportaron mayoritariamente en heces asociadas con la familia Piperaceae. Fue encontrada una baja existencia de éstos parásitos en muestras asociadas con Myrtaceae en cuyo género Psidium, se han reportado compuestos activos antiparasitarios. La aparición de parásitos fue relativamente mayor en la EBLS, comparado con muestras de otras regiones más secas de Costa Rica. Por lo tanto, esa expresión parasitaria puede deberse al hecho de ser la EBLS una selva lluviosa, además de estar rodeada por zonas con actividades antrópicas. Se sugiere incrementar las investigaciones de parasitología de campo en primates neotropicales con el fin de entender plenamente las relaciones parásitos-hospederos, para en un largo plazo poder comprender los ecosistemas donde conviven, y en consecuencia, preservar la diversidad biológica.

  4. The fabrication of sub-10 nm planar electrodes and their use for a molecule-based transistor

    Science.gov (United States)

    Visconti, P.; Della Torre, A.; Maruccio, G.; D'Amone, E.; Bramanti, A.; Cingolani, R.; Rinaldi, R.

    2004-07-01

    The typical size of a single molecule is of the order of a few nanometres; for this reason metal electrodes separated by a nanometre-scale channel are required to make molecule-based electronic devices. In this work, we report on the fabrication of metallic (Cr/Au, Ti/Au or Ti/Pt) arrow-shaped electrodes on Si/SiO2 substrates, with tip separation between 100 and less than 10 nm. They can be used to implement two and three terminal molecular devices, just by connecting them by the chosen molecules and adding an Ag electrode on the back of the Si substrate. Electron beam lithography (EBL) allowed us to obtain electrodes with separation around 40 nm. In order to reduce the tip separation down to 20 nm, before the EBL process, we used a defocused e-beam to brush the poly(methyl methacrylate) (PMMA) layer for a short time (from 10 to 40 s). The smallest gap between the electrodes (less than 10 nm) was obtained with standard EBL and lift-off followed by Au electroplating deposition. The fabricated devices were inspected by plan-view scanning electron microscopy (SEM) and electrically tested by I/V measurements in the range ± 2 V. Open-circuit characteristics gave very low currents (in the range -10 to 10 pA) and a resistance {\\approx } 1~{\\mathrm {T}}\\Omega . As a typical example, we demonstrate a field effect transistor (FET) based on a deoxyguanosine derivative (a DNA base) placed between the fabricated planar electrodes by room temperature (RT) cast deposition. The FET device tested at RT and ambient pressure exhibited a maximum voltage gain as high as 0.76.

  5. Laparoscopic Gastric Plication (LGCP) Vs Sleeve Gastrectomy (LSG): A Single Institution Experience.

    Science.gov (United States)

    Verdi, Daunia; Prevedello, Luca; Albanese, Alice; Lobba, Andrea; Foletto, Mirto

    2015-09-01

    Laparoscopic greater curvature plication (LGCP) and laparoscopic sleeve gastrectomy (LSG) both reduce gastric capacity, either by in-folding (LGCP) or removing (LSG) the greater curvature. While mid and long-term results of LSG are well known, LGCP is still considered investigational. The aim of this study was to compare the effectiveness of LGCP and LSG in terms of weight loss and safety. Forty-five obese LGCP patients (6 males and 39 females) were matched with 45 LSG patients. The two groups were matched according to sex, age ± 10 years and BMI ± 1 kg/m(2). Surgical complication rate, redo surgery need, excess BMI loss (%EBL) and mean BMI at 3 and 6 months were compared. LGCP and LSG mean age was 37.8 and 40 years, while the mean preoperative BMI was 40.65 and 41 kg/m(2), respectively. There was no difference in operative time, complication rate, mean BMI and %EBL at 3 months. Redo surgery rate was higher in LGCP group (LGCP 60 % vs LSG 8.8 %, P < 0.0001). The mean time to redo surgery was longer in LSG group (23 ± 6.61 vs 17.3 ± 7.67 months, P = 0.0003). The mean BMI at 6 months was lower in LSG group (32 ± 5.7 vs 34.6 ± 5.3, P = 0.028). The mean %EBL at 6 months was higher in LSG group (57 ± 30.89 vs 40.2 ± 25, P = 0.0057). LGCP patients required more redo surgery. Weight loss was greater in LSG group at 6-month follow-up.

  6. Hybrid metal-dielectric nanostructures for advanced light-field manipulation (Conference Presentation)

    Science.gov (United States)

    Staude, Isabelle; Guo, Rui; Rusak, Evgenia; Dominguez, Jason; Decker, Manuel; Rockstuhl, Carsten; Brener, Igal; Neshev, Dragomir N.; Pertsch, Thomas; Kivshar, Yuri S.

    2017-02-01

    All-dielectric and plasmonic nanostructures have complementary advantages regarding their capabilities for controlling light fields at the nanoscale [1]. While all-dielectric nanostructures can provide near-unity efficiency, plasmonic nanostructures are more compact and offer strong near-field enhancement. Combination of photonic nanostructures of both types offers a promising route towards compact optical elements that unify low absorption losses with small footprints, while at the same time providing a high versatility in engineering the optical response of the hybrid system towards specific functionalities. This talk aims to review our recent progress in coupling designed plasmonic nanoantennas to high-index dielectric nanostructures. Following a general analysis of coupling of plasmonic and high-refractive-index dielectric nanoresonators, various specific hybrid nanostructure designs will be discussed. For the fabrication of designed hybrid metal-dielectric nanostructures we use a two-step electron-beam lithography (EBL) procedure [2]. The first step of EBL is used in combination with reactive-ion etching to define the dielectric nanostructures. The second step of EBL is followed by evaporation of gold and a lift-off process, and serves to define the plasmonic elements. Between the two steps, a precision alignment procedure is performed in order to allow for the precise positioning of the gold nanostructures with respect to the silicon nanostructures. Using this approach, we realize and optically characterize various hybrid metal-dielectric nanostructures designed to support a range of novel functionalities, including directional emission enhancement [2] and on-chip light routing. [1] E. Rusak et al., Appl. Phys. Lett. 105, 221109 (2014). [2] R. Guo et al., ACS Photonics 3, 349-353 (2016).

  7. Comparison of surgical, functional, and oncological outcomes of open and robot-assisted partial nephrectomy

    Directory of Open Access Journals (Sweden)

    Ugur Boylu

    2015-01-01

    Full Text Available Background: We aimed to compare the surgical, oncological, and functional outcomes of robot-assisted partial nephrectomy (RAPN with open partial nephrectomy (OPN in the management of small renal masses. Materials and Methods: Between 2009 and 2013, a total of 46 RAPN patients and 20 OPN patients was included in this study. Patients′ demographics, mean operative time, estimated blood loss (EBL, warm ischemia time (WIT, length of hospital stay, pre- and post-operative renal functions, complications and oncological outcomes were recorded, prospectively. Results: Mean tumor size was 4.04 cm in OPN group and 3.56 cm in RAPN group (P = 0.27. Mean R.E.N.A.L nephrometry score was 6.35 in OPN group and 5.35 in RAPN group (P = 0.02. The mean operative time was 152 min in OPN group and 225 min in RAPN group (P = 0.006. The mean EBL in OPN and RAPN groups were 417 ml and 268 ml, respectively (P = 0.001. WIT in OPN group was significantly shorter than RAPN group (18.02 min vs. 23.33 min, P = 0.003. The mean drain removal time and the length of hospital stay were longer in OPN group. There were no significant differences in terms of renal functional outcomes and postoperative complications between groups. Conclusion: Minimally invasive surgical management of renal masses with RAPN offers better outcomes in terms of EBL and length of stay. However, the mean operative time and WIT were significantly shorter in OPN group. RAPN is a safe and effective minimally invasive alternative to OPN in terms of oncological and functional outcomes.

  8. New fabrication technique for nanoporous gold nanoparticles (Conference Presentation)

    Science.gov (United States)

    Zhao, Fusheng; Arnob, Md Masud Parvez; Shih, Wei-Chuan

    2017-02-01

    Nanoporous gold nanoparticles (NPG-NP) showcase tunable pore and ligament sizes ranging from nanometers to microns. The nanoporous structure and sub-wavelength nanoparticle shape contribute to its unique LSPR properties. NPG-NP features large specific surface area and high-density plasmonic field enhancement known as "hot-spots". Hence, NPG-NP has found many applications in nanoplasmonic sensor development. In our recent studies, we have shown that NPG-NP array chip can be utilized for high-sensitivity detection by various enhanced spectroscopic modalities, as photothermal agents, and for disease biomarker detection. To date, array-format, substrate-bound NPGN has been fabricated by either colloidal nanosphere lithography or random nucleation during the sputtering deposition process. Although highly cost-effective, these techniques cannot provide precise control of individual particle size and location. In this paper, we report the development of a new fabrication technique based on electron-beam lithography (EBL). Herein, a customized EBL technique is utilized to pattern larger areas (several square millimeters) of randomly distributed NPGN by careful design of the shot pattern, which limits the writing time to the acceptable level. Since the position, size, and shape of a huge number of features need to be generated and stored individually, memory limitations of this unique EBL technique constitutes an additional challenge, which is normally not present if small areas are to be patterned with features on an ordered lattice. This issue is solved by programmatically generating random feature positions within a simulation cell of carefully chosen size and implementing periodic boundary conditions.

  9. Line-edge quality optimization of electron beam resist for high-throughput character projection exposure utilizing atomic force microscope analysis

    Science.gov (United States)

    Ikeno, Rimon; Mita, Yoshio; Asada, Kunihiro

    2017-04-01

    High-throughput electron-beam lithography (EBL) by character projection (CP) and variable-shaped beam (VSB) methods is a promising technique for low-to-medium volume device fabrication with regularly arranged layouts, such as standard-cell logics and memory arrays. However, non-VLSI applications like MEMS and MOEMS may not fully utilize the benefits of CP method due to their wide variety of layout figures including curved and oblique edges. In addition, the stepwise shapes that appear on such irregular edges by VSB exposure often result in intolerable edge roughness, which may degrade performances of the fabricated devices. In our former study, we proposed a general EBL methodology for such applications utilizing a combination of CP and VSB methods, and demonstrated its capabilities in electron beam (EB) shot reduction and edge-quality improvement by using a leading-edge EB exposure tool, ADVANTEST F7000S-VD02, and high-resolution Hydrogen Silsesquioxane resist. Both scanning electron microscope and atomic force microscope observations were used to analyze quality of the resist edge profiles to determine the influence of the control parameters used in the exposure-data preparation process. In this study, we carried out detailed analysis of the captured edge profiles utilizing Fourier analysis, and successfully distinguish the systematic undulation by the exposed CP character profiles from random roughness components. Such capability of precise edge-roughness analysis is useful to our EBL methodology to maintain both the line-edge quality and the exposure throughput by optimizing the control parameters in the layout data conversion.

  10. Electric field dynamics in nitride structures containing quaternary alloy (Al, In, Ga)N

    Energy Technology Data Exchange (ETDEWEB)

    Borysiuk, J., E-mail: jolanta.borysiuk@ifpan.edu.pl [Institute of Physics, Polish Academy of Sciences, Al. Lotnikow 32/46, 02-668 Warsaw (Poland); Faculty of Physics, University of Warsaw, Pasteura 5, 02-093 Warsaw (Poland); Sakowski, K.; Muziol, G.; Krukowski, S. [Institute of High Pressure Physics, Polish Academy of Sciences, Sokolowska 29/37, 01-142 Warsaw (Poland); Dróżdż, P. [Faculty of Physics, University of Warsaw, Pasteura 5, 02-093 Warsaw (Poland); Institute of High Pressure Physics, Polish Academy of Sciences, Sokolowska 29/37, 01-142 Warsaw (Poland); Korona, K. P. [Faculty of Physics, University of Warsaw, Pasteura 5, 02-093 Warsaw (Poland); Sobczak, K. [Institute of Physics, Polish Academy of Sciences, Al. Lotnikow 32/46, 02-668 Warsaw (Poland); Skierbiszewski, C. [Institute of High Pressure Physics, Polish Academy of Sciences, Sokolowska 29/37, 01-142 Warsaw (Poland); TopGaN Ltd., Sokolowska 29/37, 01-142 Warsaw (Poland); Kaminska, A. [Institute of Physics, Polish Academy of Sciences, Al. Lotnikow 32/46, 02-668 Warsaw (Poland); Department of Mathematics and Natural Sciences, College of Science, Cardinal Stefan Wyszynski University, Dewajtis 5, 01-815 Warsaw (Poland)

    2016-07-07

    Molecular beam epitaxy growth and basic physical properties of quaternary AlInGaN layers, sufficiently thick for construction of electron blocking layers (EBL), embedded in ternary InGaN layers are presented. Transmission electron microscopy (TEM) measurement revealed good crystallographic structure and compositional uniformity of the quaternary layers contained in other nitride layers, which are typical for construction of nitride based devices. The AlInGaN layer was epitaxially compatible to InGaN matrix, strained, and no strain related dislocation creation was observed. The strain penetrated for limited depth, below 3 nm, even for relatively high content of indium (7%). For lower indium content (0.6%), the strain was below the detection limit by TEM strain analysis. The structures containing quaternary AlInGaN layers were studied by time dependent photoluminescence (PL) at different temperatures and excitation powers. It was shown that PL spectra contain three peaks: high energy donor bound exciton peak from the bulk GaN (DX GaN) and the two peaks (A and B) from InGaN layers. No emission from quaternary AlInGaN layers was observed. An accumulation of electrons on the EBL interface in high-In sample and formation of 2D electron gas (2DEG) was detected. The dynamics of 2DEG was studied by time resolved luminescence revealing strong dependence of emission energy on the 2DEG concentration. Theoretical calculations as well as power-dependence and temperature-dependence analysis showed the importance of electric field inside the structure. At the interface, the field was screened by carriers and could be changed by illumination. From these measurements, the dynamics of electric field was described as the discharge of carriers accumulated on the EBL.

  11. Employing Evidence Evidence: Does it Have a Job in Vocational Libraries?

    Directory of Open Access Journals (Sweden)

    Brad Jones

    2006-03-01

    Full Text Available Objective - Evidence-based librarianship (EBL springs ffrom medical and academic origins. As librarians are tertiary educated (only occasionally with supplementary qualifications covering research and statistics EBL has an academic focus. The EBL literature has significant content from school and university perspectives, but has had little, if any, vocational content. This paper suggests a possible Evidence Based Librarianship context for vocational libraries. Methods - A multidisciplinary scan of evidence based literature was undertaken, covering medicine and allied health, librarianship, law, science and education. National and international vocational education developments were examined. The concept and use of evidence in vocational libraries was considered. Results - Library practice can generally benefit from generic empirical science methodologies used elsewhere. Different areas, however, may have different concepts of what constitutes evidence and appropriate methodologies. Libraries also need to reflect the evidence used in their host organisations. The Australian vocational librarian has been functioning in an evidence based educational sector: national, transportable, prescriptive, competancy based and outcomes drived Training Packages. These require a qualitatively different concept of evidence compared to the other educational sectors as they reflect pragmatic, economic, employability outcomes. Conclusions - Vocational and other librarians have been doing research but need to be more systematic about design and analysis. Librarians need to develop 'evidence literacy' as one of their professional evaluation skills. Libraries will need to utilise evidence relevant to their host organisations to esablish and maintain credibility, and in the vocational sector this is set in a competency based framework. Competancy based measures are becoming increasingly relevant in school and university(including medical education.

  12. LA SIRENO KIU FORGESIS KIEL NA I

    Institute of Scientific and Technical Information of China (English)

    Anne Johnson

    1996-01-01

    Irena estas sireno. Si Ioas en la Kariba Maro ne longe for de Kubo. Apud la Insulo de la Gejunuloj estas multe da insuletoj kaj kelkfoje Irena eliras la akron kaj sunbanas sin. Se vi kredus pri sirenoj,eble ankaǔ vi vidus in. Estas varme, en la Kariba Maro la tutan jaron, do, i ne bezonas vestojn. Si envolvas sin en sia longa hararo kiam i volas kovri sin. Kiel vi scias, Sirenoj malsimilas al homoj nur ar anstataǔ krurojn,ili havas fivostojn. Kial mi agas kiel fakulo pri sirenoj? Do,la

  13. Micro-SQUIDs based on MgB2 nano-bridges for NEMS readout

    Science.gov (United States)

    Lolli, L.; Li, T.; Portesi, C.; Taralli, E.; Acharya, N.; Chen, K.; Rajteri, M.; Cox, D.; Monticone, E.; Gallop, J.; Hao, L.

    2016-10-01

    We show the results obtained from the fabrication and characterisation of MgB2 loops with two nano-bridges as superconducting weak links. These ring structures are made to operate as superconducting quantum interference devices and are investigated as readout system for cryogenics NEMS resonators. The nano-constrictions are fabricated by EBL and ion beam milling. The SQUIDs are characterised at different temperatures and measurements of the noise levels have been performed. The devices show high critical current densities and voltage modulations under applied magnetic field, close to the critical temperatures.

  14. Management of obstetric postpartum hemorrhage: a national service evaluation of current practice in the UK

    Directory of Open Access Journals (Sweden)

    Al Wattar BH

    2017-01-01

    Full Text Available Bassel H Al Wattar,1,* Jennifer A Tamblyn,2,* William Parry-Smith,2,* Mathew Prior,3,* Helen Van Der Nelson4,* On behalf of UK Audit and Research trainee Collaborative in Obstetrics and Gynaecology (UKARCOG 1Women’s Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, UK; 2Institute of Metabolism and Systems Research (IMSR, University of Birmingham, Birmingham, UK; 3Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK; 4Academic Centre for Women’s Health, North Bristol NHS Trust, Bristol, UK *UKARCOG Background: Postpartum hemorrhage (PPH continues to be one of the major causes of maternal mortality and morbidity in obstetrics. Variations in practice often lead to adverse maternity outcomes following PPH. Our objective was to assess the current practice in managing PPH in the UK.Methods: We performed a national multicenter prospective service evaluation study over one calendar month and compared the current performance to national standards for managing PPH. We used a standardized data collection tool and collected data on patients’ demographics, incidence of PPH, estimated blood loss (EBL, prophylactic and treatment measures, onset of labor, and mode of delivery.Results: We collected data from 98 obstetric units, including 3663 cases of primary PPH. Fifty percent of cases were minor PPH (EBL 500–1000 mL, n=1900/3613, 52.6% and the remaining were moderate PPH (EBL >1000 to <2000 mL, n=1424/3613, 39.4% and severe PPH (EBL >2000 mL, n=289/3613, 8%. The majority of women received active management of the third stage of labor (3504/3613, 97% most commonly with Syntometrine intramuscular (1479/3613, 40.9%. More than half required one additional uterotonic agent (2364/3613, 65.4% most commonly with Syntocinon intravenous infusion (1155/2364, 48.8%. There was a poor involvement of consultant obstetricians and anesthetists in

  15. Evidence for the Sialylation of PilA, the PI-2a Pilus-Associated Adhesin of Streptococcus agalactiae Strain NEM316.

    Science.gov (United States)

    Morello, Eric; Mallet, Adeline; Konto-Ghiorghi, Yoan; Chaze, Thibault; Mistou, Michel-Yves; Oliva, Giulia; Oliveira, Liliana; Di Guilmi, Anne-Marie; Trieu-Cuot, Patrick; Dramsi, Shaynoor

    2015-01-01

    Streptococcus agalactiae (or Group B Streptococcus, GBS) is a commensal bacterium present in the intestinal and urinary tracts of approximately 30% of humans. We and others previously showed that the PI-2a pilus polymers, made of the backbone pilin PilB, the tip adhesin PilA and the cell wall anchor protein PilC, promote adhesion to host epithelia and biofilm formation. Affinity-purified PI-2a pili from GBS strain NEM316 were recognized by N-acetylneuraminic acid (NeuNAc, also known as sialic acid) specific lectins such as Elderberry Bark Lectin (EBL) suggesting that pili are sialylated. Glycan profiling with twenty different lectins combined with monosaccharide composition by HPLC suggested that affinity-purified PI-2a pili are modified by N-glycosylation and decorated with sialic acid attached to terminal galactose. Analysis of various relevant mutants in the PI-2a pilus operon by flow-cytometry and electron microscopy analyses pointed to PilA as the pilus subunit modified by glycosylation. Double labeling using PilB antibody and EBL lectin, which specifically recognizes N-acetylneuraminic acid attached to galactose in α-2, 6, revealed a characteristic binding of EBL at the tip of the pilus structures, highly reminiscent of PilA localization. Expression of a secreted form of PilA using an inducible promoter showed that this recombinant PilA binds specifically to EBL lectin when produced in the native GBS context. In silico search for potentially glycosylated asparagine residues in PilA sequence pointed to N427 and N597, which appear conserved and exposed in the close homolog RrgA from S. pneumoniae, as likely candidates. Conversion of these two asparagyl residues to glutamyl resulted in a higher instability of PilA. Our results provide the first evidence that the tip PilA adhesin can be glycosylated, and suggest that this modification is critical for PilA stability and may potentially influence interactions with the host.

  16. Electric vehicles from the point of view of an energy utility; Elektrofahrzeuge aus Sicht eines Energieversorgers

    Energy Technology Data Exchange (ETDEWEB)

    Corpataux, M.

    2008-07-01

    This presentation made at the Swiss 2008 research conference on traffic by Marcel Corpataux from the Elektra Baselland utility (EBL) takes a look at the utility's activities in the renewable energies sector and the need for balancing energy supply and demand. Various methods on the demand side are briefly looked at and the use of 'vehicle-to-grid' concepts that use hybrid vehicles as storage facilities for electrical power are commented on. The chances offered to electricity utilities by using hybrid vehicles as buffer storage for electrical power are discussed.

  17. The opacity of the universe for high and very high energy {gamma}-rays

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Manuel

    2013-08-15

    The flux of high energy (HE, energy 100 MeVor similar 100 GeV) {gamma}-rays originating from cosmological sources is attenuated due to pair production in interactions with photons at ultraviolet to infrared wavelengths of the extragalactic background light (EBL). The main components contributing to the EBL photon density are the starlight integrated over cosmic time and the starlight reprocessed by dust in galaxies. Consequently, the EBL is an integral measure of the cosmic star formation history. Depending on the source distance, the Universe should be opaque to {gamma}-rays above a certain energy. Nevertheless, the number of detected {gamma}-ray sources has increased continuously in recent years. VHE emitting objects beyond redshifts of z>0.5 have been detected with imaging air Cherenkov telescopes (IACTs), while HE {gamma}-rays from active galactic nuclei (AGN) above redshifts z>or similar 3 have been observed with the Large Area Telescope (LAT) on board the Fermi satellite. In this work, a large sample of VHE {gamma}-ray spectra will be combined with data of the Fermi-LAT to derive upper limits on the EBL photon density at z = 0. Generic EBL realizations are used to correct AGN spectra for absorption, which are subsequently tested against model assumptions. The evolution of the EBL with redshift is accounted for, and a possible formation of electromagnetic cascades is considered. As a result, the EBL density is constrained over almost three orders of magnitude in wavelength, between 0.4 {mu}m and 100 {mu}m. At optical wavelengths, an EBL intensity above 24 nW m{sup -2}sr{sup -1} is ruled out, and between 8 {mu}m and 31 {mu}m it is limited to be below 5 nW m{sup -2}sr{sup -1}. In the infrared, the constraints are within a factor {proportional_to} 2 of lower limits derived from galaxy number counts. Additionally,the behavior of VHE spectra in the transition from the optical depth regimes {tau

  18. Complete data preparation flow for Massively Parallel E-Beam lithography on 28nm node full-field design

    Science.gov (United States)

    Fay, Aurélien; Browning, Clyde; Brandt, Pieter; Chartoire, Jacky; Bérard-Bergery, Sébastien; Hazart, Jérôme; Chagoya, Alexandre; Postnikov, Sergei; Saib, Mohamed; Lattard, Ludovic; Schavione, Patrick

    2016-03-01

    Massively parallel mask-less electron beam lithography (MP-EBL) offers a large intrinsic flexibility at a low cost of ownership in comparison to conventional optical lithography tools. This attractive direct-write technique needs a dedicated data preparation flow to correct both electronic and resist processes. Moreover, Data Prep has to be completed in a short enough time to preserve the flexibility advantage of MP-EBL. While the MP-EBL tools have currently entered an advanced stage of development, this paper will focus on the data preparation side of the work for specifically the MAPPER Lithography FLX-1200 tool [1]-[4], using the ASELTA Nanographics Inscale software. The complete flow as well as the methodology used to achieve a full-field layout data preparation, within an acceptable cycle time, will be presented. Layout used for Data Prep evaluation was one of a 28 nm technology node Metal1 chip with a field size of 26x33mm2, compatible with typical stepper/scanner field sizes and wafer stepping plans. Proximity Effect Correction (PEC) was applied to the entire field, which was then exported as a single file to MAPPER Lithography's machine format, containing fractured shapes and dose assignments. The Soft Edge beam to beam stitching method was employed in the specific overlap regions defined by the machine format as well. In addition to PEC, verification of the correction was included as part of the overall data preparation cycle time. This verification step was executed on the machine file format to ensure pattern fidelity and accuracy as late in the flow as possible. Verification over the full chip, involving billions of evaluation points, is performed both at nominal conditions and at Process Window corners in order to ensure proper exposure and process latitude. The complete MP-EBL data preparation flow was demonstrated for a 28 nm node Metal1 layout in 37 hours. The final verification step shows that the Edge Placement Error (EPE) is kept below 2.25 nm

  19. Ultraviolet light-emitting diodes with polarization-doped p-type layer

    Science.gov (United States)

    Hu, Wenxiao; Qin, Ping; Song, Weidong; Zhang, Chongzhen; Wang, Rupeng; Zhao, Liangliang; Xia, Chao; Yuan, Songyang; Yin, Yian; Li, Shuti

    2016-09-01

    We report ultraviolet light emitting diode (LEDs) with polarization doped p-type layer. Fabricated LEDs with polarization doped p-type layer exhibited reduced forward voltage and enhanced light output power, compared to those with traditional p-type AlGaN layer. The improvement is attributed to improved hole concentration and the smooth valence band by the polarization enhanced p-type doping. Our simulated results reveal that this p-type layer can further enhance the performance of ultraviolet LEDs by removing the electron blocking layer (EBL).

  20. Anti-Plasmodium falciparum invasion ligand antibodies in a low malaria transmission region, Loreto, Peru

    DEFF Research Database (Denmark)

    Villasis, Elizabeth; Lopez-Perez, Mary; Torres, Katherine

    2012-01-01

    , PfRh2a and PfRh2b and IgG3 response for PfRh2a were also negatively correlated with parasitaemia. Conclusions: These data suggest that falciparum malaria patients who develop clinical immunity (asymptomatic parasitaemia) in a low transmission setting such as the Peruvian Amazon have antibody......Background: Erythrocyte invasion by Plasmodium falciparum is a complex process that involves two families; Erythrocyte Binding-Like (EBL) and the Reticulocyte Binding-Like (PfRh) proteins. Antibodies that inhibit merozoite attachment and invasion are believed to be important in mediating naturally...

  1. Hybrid Integrated Si/SiN Platforms for Wideband Optical Processing

    Science.gov (United States)

    2017-05-08

    through an aligned EBL, selective dry etching of the ALD oxide in F-based plasma to reach to Si pedestal, followed by an e-beam evaporation of a 500 nm...DISTRIBUTION A: Distribution approved for public release. 6 comparing plasma -enhanced chemical vapor deposition (PECVD), ALD, and hydrogen silsesquioxane (HSQ... etching processes to carve out channels of 10 μm width with 250 μm spacing from each other. As shown in Figure 1-d, by adding these "vent channels

  2. 什么人长寿?(英文)

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    iuj homoj mortas.Sed iuj vivas longedum aliaj mallonge.En Kaǔkazio~* 50 el 100000 homoj vivas pliol cent jarojn.En Usono~* ,nur 3 el 100000 ho-moj povas vivi tiel longe.En Gruzio~* iuj 110-jaraj aǔ 140-jaraj homoj e laboras en kampo!Oni demandis al ili,kiam,laǔ ili,iliaj junafofiniis.Iuj el ili respondis:"Eble kiam mi estis80-jara." Alia respondo estas:"Kiam mi estis60-kelkjara."

  3. E-book usage on a global scale: patterns, trends and opportunities

    Directory of Open Access Journals (Sweden)

    Michael Levine-Clark

    2015-07-01

    Full Text Available This study examines worldwide usage of over 600,000 e-books from EBL and ebrary. Using multiple modes of analysis, the study shows that there are variations in usage by geographic region as well as by subject. The study examines usage in relation to availability of titles, different types of usage per session, usage of the top ten percent of titles, and intensive and extensive use. These patterns can be used for benchmarking and as a model for local e-book studies.

  4. Plasmonic colour laser printing

    DEFF Research Database (Denmark)

    Zhu, Xiaolong; Vannahme, Christoph; Højlund-Nielsen, Emil

    2016-01-01

    -beam lithography (EBL) or focused ion beam (FIB), both expensive and not scalable processes that are not suitable for post-processing customization. Here we show a method of colour printing on nanoimprinted plasmonic metasurfaces using laser post-writing. Laser pulses induce transient local heat generation...... that leads to melting and reshaping of the imprinted nanostructures. Depending on the laser pulse energy density, different surface morphologies that support different plasmonic resonances leading to different colour appearances can be created. Using this technique we can print all primary colours...

  5. Detection of infrared photons with a superconductor

    Institute of Scientific and Technical Information of China (English)

    ZHANG LaBao; ZHONG YangYin; KANG Lin; CHEN Jian; JI ZhengMing; XU WeiWei; CAO ChunHai

    2009-01-01

    A superconductor single photon detector based on NbN nanowire was fabricated using electron beam lithography (EBL) and reactive ion etching (RIE) for infrared photon detection. When biased well below its critical current at 4.2 K, NbN nanowire is very sensitive to the incident photons. Typical telecommunication photons with a wavelength of 1550 nm were detected by this detector. Data analysis indicates the repeating rate of the device with 200 nm NbN nanowire may be up to 100 MHz, and the quantum efficiency is about 0.01% when biased at 0.95Ic.

  6. 2007~2009年上海市规模化养牛场牛白血病血清学调查

    Institute of Scientific and Technical Information of China (English)

    李凯航; 陈秉楠; 王建

    2011-01-01

    @@ 流行性牛白血病是由病毒引起的牛的一种慢性肿瘤性疾病.其特征为淋巴样细胞恶性增生,进行性恶病质和发病后的高死亡率,此病在世界各地都有发生.根据其流行状态和疾病的表现形式可将其分为流行性牛白血病(Enzootic Bovine Leukosis,EBL)和散发性牛白血病(Sporadic Bovine Leukosis,SBL).

  7. Plasmodium falciparum Field Isolates from South America Use an Atypical Red Blood Cell Invasion Pathway Associated with Invasion Ligand Polymorphisms

    Science.gov (United States)

    Lopez-Perez, Mary; Villasis, Elizabeth; Machado, Ricardo L. D.; Póvoa, Marinete M.; Vinetz, Joseph M.; Blair, Silvia; Gamboa, Dionicia; Lustigman, Sara

    2012-01-01

    Studies of Plasmodium falciparum invasion pathways in field isolates have been limited. Red blood cell (RBC) invasion is a complex process involving two invasion protein families; Erythrocyte Binding-Like (EBL) and the Reticulocyte Binding-Like (PfRh) proteins, which are polymorphic and not fully characterized in field isolates. To determine the various P. falciparum invasion pathways used by parasite isolates from South America, we studied the invasion phenotypes in three regions: Colombia, Peru and Brazil. Additionally, polymorphisms in three members of the EBL (EBA-181, EBA-175 and EBL-1) and five members of the PfRh (PfRh1, PfRh2a, PfRh2b, PfRh4, PfRh5) families were determined. We found that most P. falciparum field isolates from Colombia and Peru invade RBCs through an atypical invasion pathway phenotypically characterized as resistant to all enzyme treatments (NrTrCr). Moreover, the invasion pathways and the ligand polymorphisms differed substantially among the Colombian and Brazilian isolates while the Peruvian isolates represent an amalgam of those present in the Colombian and Brazilian field isolates. The NrTrCr invasion profile was associated with the presence of the PfRh2a pepC variant, the PfRh5 variant 1 and EBA-181 RVNKN variant. The ebl and Pfrh expression levels in a field isolate displaying the NrTrCr profile also pointed to PfRh2a, PfRh5 and EBA-181 as being possibly the major players in this invasion pathway. Notably, our studies demonstrate the uniqueness of the Peruvian P. falciparum field isolates in terms of their invasion profiles and ligand polymorphisms, and present a unique opportunity for studying the ability of P. falciparum parasites to expand their invasion repertoire after being reintroduced to human populations. The present study is directly relevant to asexual blood stage vaccine design focused on invasion pathway proteins, suggesting that regional invasion variants and global geographical variation are likely to preclude a simple

  8. High-contrast process using a positive-tone resist with antistatic coating and high-energy (100-keV) e-beam lithography for fabricating diffractive optical elements (DOE) on quartz

    Science.gov (United States)

    Poli, Louis C.; Kondek, Christine A.; Shoop, Barry L.; McLane, George F.

    1995-06-01

    Diffractive optical elements (DOE) are becoming important as optical signal processing elements in increasingly diverse applications. These elements, fabricated on quartz, may be used as phase shift type masks or as embedded components that implement a transfer function within a processing network. A process is under development for the fabrication of a DOE implementing a Jervis error diffusion kernel for research in half tone image processing. Dry etching is performed after lithography and pattern transfer through a nickel mask. This results in etched areal features on the substrate. An optical diffraction medium is thus created. Lithographic patterning is done by e-beam lithography (EBL) to realize small features, but also offers the important advantage of a large depth of field which relaxes the problem of complex surface topology. The recent availability of high energy (100 KeV) lithography tools provides a capability for precision overlay, small feature resolution, and enhanced image contrast through a lower induced proximity effect. Patterning by EBL on insulating substrates is complicated by the necessity of providing a vehicle for the avoidance of charge buildup on the surface. In a previously presented paper a methodology was shown for the use of TQV-501 (Nitto Chemical) antistatic compound as a final spin on film for use with PMMA and SAL-601 (Shipley). In this current work, a process is described using EBL and a high performance positive resist working with a final film layer of antistatic TQV-501 on a nickel coated wafer. The process may then be reapplied to realize additional lithographic levels in registration, for multilevel DOE components. High energy (100 KeV) EBL is used to provide high quality pattern definition. The e-beam sensitive resist, ZEP-320-37 (Nagase Chemical) in dilution, together with a top film layer of TQV-501 serves as a bilevel resist system and is used for patterning the desired image before definition of the nickel mask through

  9. Plasmodium falciparum field isolates from South America use an atypical red blood cell invasion pathway associated with invasion ligand polymorphisms.

    Directory of Open Access Journals (Sweden)

    Mary Lopez-Perez

    Full Text Available Studies of Plasmodium falciparum invasion pathways in field isolates have been limited. Red blood cell (RBC invasion is a complex process involving two invasion protein families; Erythrocyte Binding-Like (EBL and the Reticulocyte Binding-Like (PfRh proteins, which are polymorphic and not fully characterized in field isolates. To determine the various P. falciparum invasion pathways used by parasite isolates from South America, we studied the invasion phenotypes in three regions: Colombia, Peru and Brazil. Additionally, polymorphisms in three members of the EBL (EBA-181, EBA-175 and EBL-1 and five members of the PfRh (PfRh1, PfRh2a, PfRh2b, PfRh4, PfRh5 families were determined. We found that most P. falciparum field isolates from Colombia and Peru invade RBCs through an atypical invasion pathway phenotypically characterized as resistant to all enzyme treatments (NrTrCr. Moreover, the invasion pathways and the ligand polymorphisms differed substantially among the Colombian and Brazilian isolates while the Peruvian isolates represent an amalgam of those present in the Colombian and Brazilian field isolates. The NrTrCr invasion profile was associated with the presence of the PfRh2a pepC variant, the PfRh5 variant 1 and EBA-181 RVNKN variant. The ebl and Pfrh expression levels in a field isolate displaying the NrTrCr profile also pointed to PfRh2a, PfRh5 and EBA-181 as being possibly the major players in this invasion pathway. Notably, our studies demonstrate the uniqueness of the Peruvian P. falciparum field isolates in terms of their invasion profiles and ligand polymorphisms, and present a unique opportunity for studying the ability of P. falciparum parasites to expand their invasion repertoire after being reintroduced to human populations. The present study is directly relevant to asexual blood stage vaccine design focused on invasion pathway proteins, suggesting that regional invasion variants and global geographical variation are likely to

  10. Overshoot effects of electron on efficiency droop in InGaN/GaN MQW light-emitting diodes

    Directory of Open Access Journals (Sweden)

    Yang Huang

    2016-04-01

    Full Text Available To evaluate electron leakage in InGaN/GaN multiple quantum well (MQW light emitting diodes (LEDs, analytic models of ballistic and quasi-ballistic transport are developed. With this model, the impact of critical variables effecting electron leakage, including the electron blocking layer (EBL, structure of multiple quantum wells (MQWs, polarization field, and temperature are explored. The simulated results based on this model shed light on previously reported experimental observations and provide basic criteria for suppressing electron leakage, advancing the design of InGaN/GaN LEDs.

  11. The customer is always right? Assessing the value of patron-driven acquisition at the University of Huddersfield

    Directory of Open Access Journals (Sweden)

    Graham Stone

    2015-03-01

    Full Text Available A small-scale patron-driven acquisition (PDA study at the University of Huddersfield is discussed in this article. The authors briefly describe the background to PDA at Huddersfield before discussing data from the 2014 PDA pilot with the e-book supplier Ebook Library (EBL. The pilot produced two sets of data, usage reports using COUNTER statistics and a short questionnaire designed by the Library. These results led to a major alteration to the collection management and development policy, where PDA is now embedded into the Library book fund.

  12. Gate-tuned negative differential resistance observed at room temperature in an array of gold nanoparticles

    Science.gov (United States)

    Huong, Tran Thi Thu; Matsumoto, Kazuhiko; Moriya, Masataka; Shimada, Hiroshi; Kimura, Yasuo; Hirano-Iwata, Ayumi; Mizugaki, Yoshinao

    2017-04-01

    We fabricated a single-electron (SE) device using gold nanoparticles (Au NPs). Drain, source, and gate electrodes on a SiO{_2}/Si substrate were formed using electron beam lithography (EBL) and thermal evaporation of Au. Subsequently, solutions of 3-nm-diameter and 5-nm-diameter Au NPs were dropped on the device to make current paths through Au NPs among the electrodes. Measurements of the device exhibited negative differential resistance (NDR) in the current-voltage characteristics between the drain and source electrodes at room temperature (298 K). The NDR behavior was tuned by applying a gate voltage.

  13. Anti-Plasmodium falciparum invasion ligand antibodies in a low malaria transmission region, Loreto, Peru

    Directory of Open Access Journals (Sweden)

    Villasis Elizabeth

    2012-10-01

    Full Text Available Abstract Background Erythrocyte invasion by Plasmodium falciparum is a complex process that involves two families; Erythrocyte Binding-Like (EBL and the Reticulocyte Binding-Like (PfRh proteins. Antibodies that inhibit merozoite attachment and invasion are believed to be important in mediating naturally acquired immunity and immunity generated by parasite blood stage vaccine candidates. The hypotheses tested in this study were 1 that antibody responses against specific P. falciparum invasion ligands (EBL and PfRh differ between symptomatic and asymptomatic individuals living in the low-transmission region of the Peruvian Amazon and 2, such antibody responses might have an association, either direct or indirect, with clinical immunity observed in asymptomatically parasitaemic individuals. Methods ELISA was used to assess antibody responses (IgG, IgG1 and IgG3 against recombinant P. falciparum invasion ligands of the EBL (EBA-175, EBA-181, EBA-140 and PfRh families (PfRh1, PfRh2a, PfRh2b, PfRh4 and PfRh5 in 45 individuals infected with P. falciparum from Peruvian Amazon. Individuals were classified as having symptomatic malaria (N=37 or asymptomatic infection (N=8. Results Antibody responses against both EBL and PfRh family proteins were significantly higher in asymptomatic compared to symptomatic individuals, demonstrating an association with clinical immunity. Significant differences in the total IgG responses were observed with EBA-175, EBA-181, PfRh2b, and MSP119 (as a control. IgG1 responses against EBA-181, PfRh2a and PfRh2b were significantly higher in the asymptomatic individuals. Total IgG antibody responses against PfRh1, PfRh2a, PfRh2b, PfRh5, EBA-175, EBA-181 and MSP119 proteins were negatively correlated with level of parasitaemia. IgG1 responses against EBA-181, PfRh2a and PfRh2b and IgG3 response for PfRh2a were also negatively correlated with parasitaemia. Conclusions These data suggest that falciparum malaria patients who develop

  14. Design considerations for a compact proton beam writing system aiming for fast sub-10 nm direct write lithography

    Science.gov (United States)

    Xu, Xinxin; Liu, Nannan; Raman, P. Santhana; Qureshi, Sarfraz; Pang, Rudy; Khursheed, Anjam; van Kan, Jeroen A.

    2017-08-01

    In order to realize sub-10 nm feature size by proton beam writing (PBW) with writing speed comparable to electron beam lithography (EBL), a 200 kV compact PBW system is proposed here. In this system, a new nano-aperture electron impact ion source with a potential reduced brightness of 106 A/(m2 srV) will be employed. To achieve sub-10 nm spot sizes with pA beam current, two different focusing lens configurations were evaluated. Both of these configurations were found to be theoretically capable of achieving sub-10 nm beam spot size.

  15. Correction of severe spinopelvic mismatch: decreased blood loss with lateral hyperlordotic interbody grafts as compared with pedicle subtraction osteotomy.

    Science.gov (United States)

    Leveque, Jean-Christophe; Yanamadala, Vijay; Buchlak, Quinlan D; Sethi, Rajiv K

    2017-08-01

    OBJECTIVE Pedicle subtraction osteotomy (PSO) provides extensive correction in patients with fixed sagittal plane imbalance but is associated with high estimated blood loss (EBL). Anterior column realignment (ACR) with lateral graft placement and sectioning of the anterior longitudinal ligament allows restoration of lumbar lordosis (LL). The authors compare peri- and postoperative measures in 2 groups of patients undergoing correction of a sagittal plane imbalance, either through PSO or the use of lateral lumbar fusion and ACR with hyperlordotic (20°-30°) interbody cages, with stabilization through standard posterior instrumentation in all cases. METHODS The authors performed a retrospective chart review of cases involving a lumbar PSO or lateral lumbar interbody fusion and ACR (LLIF-ACR) between 2010 and 2015 at the authors' institution. Patients who had a PSO in the setting of a preexisting fusion that spanned more than 4 levels were excluded. Demographic characteristics, spinopelvic parameters, EBL, operative time, and LOS were analyzed and compared between patients treated with PSO and those treated with LLIF-ACR. RESULTS The PSO group included 14 patients and the LLIF-ACR group included 13 patients. The mean follow-up was 13 months in the LLIF-ACR group and 26 months in the PSO group. The mean EBL was significantly lower in the LLIF-ACR group, measuring approximately 50% of the mean EBL in the PSO group (1466 vs 2910 ml, p 0.05), as was the preoperative PI-LL mismatch (33° in each group, p > 0.05) and the postoperative PI-LL mismatch ( 0.5). The total operative time and LOS were not significantly different in the 2 groups. CONCLUSIONS This is the first direct comparison of the LLIF-ACR technique with the PSO in adult spinal deformity correction. The study demonstrates that the LLIF-ACR provides equivalent deformity correction with significantly reduced blood loss in patients with a previously unfused spine compared with the PSO. This technique provides a

  16. Overshoot effects of electron on efficiency droop in InGaN/GaN MQW light-emitting diodes

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Yang; Liu, Zhiqiang, E-mail: lzq@semi.ac.cn, E-mail: spring@semi.ac.cn; Yi, Xiaoyan, E-mail: lzq@semi.ac.cn, E-mail: spring@semi.ac.cn; Guo, Yao; Wu, Shaoteng; Yuan, Guodong; Wang, JunXi; Wang, Guohong; Li, Jinmin [R& D Center for Semiconductor Lighting, Chinese Academy of Sciences, Beijing 100083 (China); State Key Laboratory of Solid State Lighting, Beijing 100083 (China); Beijing Engineering Research Center for the 3rd Generation Semiconductor Materials and Application, Beijing 100083 (China)

    2016-04-15

    To evaluate electron leakage in InGaN/GaN multiple quantum well (MQW) light emitting diodes (LEDs), analytic models of ballistic and quasi-ballistic transport are developed. With this model, the impact of critical variables effecting electron leakage, including the electron blocking layer (EBL), structure of multiple quantum wells (MQWs), polarization field, and temperature are explored. The simulated results based on this model shed light on previously reported experimental observations and provide basic criteria for suppressing electron leakage, advancing the design of InGaN/GaN LEDs.

  17. The Lowland Rivers of The Netherlands - Geodiversity and Cultural Heritage on 19th and early 20th century Landscape Paintings

    Science.gov (United States)

    Jungerius, Pieter Dirk; van den Ancker, Hanneke; Moes, Constance

    2015-04-01

    are straightened and the flow is regulated by groins; - large-stem orchards on the river banks are replaced by low-stem orchards; - big trees still grow on the river banks on the oldest paintings; - 19th century dikes align the river and are low compared to modern dikes; - transport of trade goods always has been an important river function; - the 19th century small-scale shipyards have disappeared from the banks; - ferry crossings remained a popular painting object, while bridges are seldom depicted - building bridges started in the mid-19th century; - commercial fishery on migrating salmon has disappeared since; - skating scenes indicate the rivers froze more often in this period. References Jungerius, van den Ancker & Wevers, 2012. The contribution of Dutch landscape painters to the conservation of geoheritage. Geology Today 28,3. Hanneke van den Ancker & Pieter Dirk Jungerius, 2012. Landscape paintings, a tool for research, planning and management of the coastal zone. EGU-SSS, Vienna. Hanneke van den Ancker & Pieter Dirk Jungerius, 2013. Geodiversity changes in Dutch peatlands illustrated by 19th and early 20th century landscape paintings. EGU-SSS, Vienna. Hanneke van den Ancker & Pieter Dirk Jungerius, 2014. Geodiversity-Biodiversity relationships in Dutch Sand Landscapes illustrated by 19th and early 20th century landscape paintings. EGU-SSS, Vienna.

  18. Diagnóstico sobre la gestión documental y de archivos en la Universidad Central Marta Abreu de las Villas. Cuba: Caso de estudio

    Directory of Open Access Journals (Sweden)

    Font Aranda, Odalys

    2012-12-01

    Full Text Available The organization of information is necessary, among other reasons, for providing evidence of facts and for conserving the documents; this is apparent in the concept offered by various authors regarding records management and which is summarized, to some extent, in this article. Due to the nonexistence of a system for records and archives management at the Central University «Marta Abreu» of the Villas (UCLV, Cuba, a diagnostic was performed with the objective of implementing an efficient system to regulate the processes and to allow a control of the documentation. Diverse techniques were used, including interviews, surveys and observations, while bearing in mind the DIRKS methodology (Designing and Implementing Recordkeeping System. The importance of carrying out a diagnostic is discussed, with references to similar studies. The article concludes by distinguishing between the strengths and weaknesses of records and archives management in this institution, which will serve as a preamble for the execution of the final objective of the investigation.

    La organización de la información es necesaria entre otras razones, para evidenciar los hechos y conservar los documentos; esto se pone de manifiesto en el concepto dado por algunos autores sobre Gestión Documental, lo que se resume en alguna medida en este artículo. Debido a la inexistencia de un Sistema de Gestión Documental y de Archivos en la Universidad Central «Marta Abreu» de las Villas (UCLV Cuba, se realiza un diagnóstico con el objetivo de implementar un sistema que regule los procesos y permita un control de la documentación. Se utilizan diversas técnicas: entrevistas, encuestas y observaciones; teniendo en cuenta la metodología DIRKS Designing and Implementing Recordkeeping System (Diseño e implementación de sistemas de gestión de registros. Se aborda la importancia de realizar el diagnóstico sobre el tema referenciando investigaciones semejantes a este

  19. Book Reviews

    Directory of Open Access Journals (Sweden)

    Book Review Editor, Barbara Hogenboom

    2014-10-01

    Full Text Available The Economic History of the Caribbean since the Napoleonic Wars, by Victor Bulmer-Thomas (2012; reviewed by Gert OostindieSubjects or Citizens: British Caribbean Workers in Cuba, 1900-1960, by Robert Whitney and Graciela Chailloux Laffita (2013; reviewed by Rose Mary AllenDebating Civil-Military Relations in Latin America, editado por David Mares y Rafael Martínez (2014; reseñado por Raul Benitez-ManautComparative Public Policy in Latin America, editado por Jordi Díez y Susan Franceschet (2012; reseñado por Gonzalo DelamazaEntre el desarrollo y el buen vivir. Recursos naturales y conflictos en los territorios indígenas, editado por José Aylwin, Salvador Martí i Puig, Claire Wright y Nancy Yañez (2013; reviewed by Almut Schilling-VacaflorDignity for the Voiceless. Willem Assies’s Anthropological Work in Context, editado por Ton Salman, Salvador Martí i Puig, y Gemma van der Haar (2014; reseñado por Ricardo Calla OrtegaDemocracy in ‘Two Mexicos’; Political Institutions in Oaxaca and Nuevo León, by Guadelupe Correa-Cabrera (2013; reviewed by Jos BartmanWhere the River Ends, by Shaylih Muehlmann (2013; reviewed by Maria L. Cruz-TorresKnowing History in Mexico. An ethnography of Citizenship, by Trevor Stack (2012; reviewed by Raymond BuveFor God and Revolution. Priest, Peasant, and Agrarian Socialism in the Mexican Huasteca, por Mark Saad Saka( 2013; reseñado por Antonio Escobar OhmstedeWorking Women, Entrepreneurs, and the Mexican Revolution: the Coffee Culture of Córdoba, Veracruz, by Heather Fowler-Salamini (2013; reviewed by Robert F. AlegreWar by Other Means. Aftermath in Post-Genocide Guatemala, edited by Carlota McAlister and Diana Nelson (2013; reviewed by Dirk KruijtLucha revolucionaria. Perú, 1958-1967, por Jan Lust (2013; reseñado por Dirk KruijtWomen in War. The Micro-Processes of Mobilization in El Salvador, by Jocelyn Viterna (2013; reviewed by Ralph SprenkelsZero Hunger: Political Culture and Antipoverty Policy in

  20. Next Art (and Media Education - 7 Thesen zum Selbstverständnis der pädagogisch motivierten Auseinandersetzung mit Kunst im Kontext aktueller Medienkultur

    Directory of Open Access Journals (Sweden)

    Torsten Meyer

    2014-06-01

    Full Text Available Die nächste Kunst ist die Kunst der nächsten Gesellschaft. Als nächste Gesellschaft bezeichnet der Soziologe und Kulturtheoretiker Dirk Baecker – im Anschluss an den Managementdenker Peter F. Drucker – die Gesellschaft, die auf dem Computer als geschäftsführender Medientechnologie basiert. Baecker geht dabei von der u.a. auch von Marshall McLuhan, Manuel Castells, Niklas Luhmann, Régis Debray und anderen formulierten Vermutung aus, dass kaum etwas so große Bedeutung für die Strukturen einer Gesellschaft und die Formen einer Kultur hat wie die jeweils dominierenden Verbreitungsmedien. Folglich wird die Einführung des Computers für die Gesellschaft ebenso dramatische Folgen haben wie zuvor nur die Einführung der Sprache, der Schrift und des Buchdrucks. Next Art Education ist der Versuch, an diese Vermutung mit der Frage nach adäquaten Reaktionen im Feld der Verkoppelung von Kunst und Pädagogik anzuschließen. Next Art (and Media Education ist der Versuch, diese Vermutung in den Diskurs der Medienpädagogik zu übertragen. Next art is the art of the next society. Dirk Baecker pinpoints the term Next Society to those societies based upon the computer as the leading form of media technology. Baecker furthermore builds his argument on the assumption – also conveyed by Marshall McLuhan, Manuel Castells, Niklas Luhmann, Régis Debray, among others – that nothing influences societal structures or cultural forms as significantly as the respective dominating media technology. As a result the introduction of the computer into society will produce the same dramatic impact as has previously only been caused by the introduction of language, writing and printing. Next Art Education is the attempt to connect this hypothesis with adequate reactions within the field of art education. Next Art (and Media Education is the attempt to bring this hypothesis into the discourse of Media Education.