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Sample records for brown phd md

  1. Perspective: PhD scientists completing medical school in two years: looking at the Miami PhD-to-MD program alumni twenty years later.

    Science.gov (United States)

    Koniaris, Leonidas G; Cheung, Michael C; Garrison, Gwen; Awad, William M; Zimmers, Teresa A

    2010-04-01

    Producing and retaining physician-scientists remains a major challenge in advancing innovation, knowledge, and patient care across all medical disciplines. Various programs during medical school, including MD-PhD programs, have been instituted to address the need for continued production of physician-scientists. From 1971 through 1989, 508 students with a prior PhD in the sciences, mathematics, or engineering graduated in two years from an accelerated MD program at the University of Miami School of Medicine. The program, designed to address potential clinical physician shortages rather than physician-scientist shortages, quickly attracted many top-notch scientists to medicine. Many program graduates went to top-tier residencies, pursued research careers in academic medicine, and became academic leaders in their respective fields. A retrospective examination of graduates conducted in 2008-2009 demonstrated that approximately 59% took positions in academic university medical departments, 3% worked for governmental agencies, 5% entered industry as researchers or executives, and 33% opted for private practice. Graduates' positions included 85 full professors, 11 university directors or division heads, 14 academic chairs, 2 medical school deans, and 1 astronaut. Overall, 30% of graduates had obtained National Institutes of Health funding after completing the program. These results suggest that accelerated medical training for accomplished scientists can produce a large number of successful physician-scientists and other leaders in medicine. Furthermore, these results suggest that shortening the medical portion of combined MD-PhD programs might also be considered. PMID:20354390

  2. A Conversation with Larry Brown

    OpenAIRE

    Dasgupta, Anirban

    2005-01-01

    Lawrence D. Brown was born on December 16, 1940 in Los Angeles, California. He obtained his Ph.D. in mathematics from Cornell University in 1964. He has been on the faculty of the University of California, Berkeley, Cornell University, Rutgers University and, most recently, the Wharton School of the University of Pennsylvania, where he holds the Miers Busch Professorship of Statistics. Professor Brown was President of the Institute of Mathematical Statistics in 1992–1993, Coeditor of The Anna...

  3. Anthrax. William Smith Greenfield, M.D., F.R.C.P., Professor Superintendent, the Brown Animal Sanatory Institution (1878-81). Concerning the priority due to him for the production of the first vaccine against anthrax.

    OpenAIRE

    Tigertt, W. D.

    1980-01-01

    The purpose of this paper is to draw attention to the fact that W. S. Greenfield, working at the Brown Animal Sanatory Institution in London, prepared an effective vaccine against anthrax and described his results some months before the experiment of Pasteur at Pouilly-le-fort. Partly through lack of financial support and partly due to opposition by the antivivisectionists, Greenfield was forced to confine his experiments to a small number of animals, but his results were nevertheless conclus...

  4. ATLAS PHd Grants 2015

    CERN Multimedia

    Marcelloni De Oliveira, Claudia

    2015-01-01

    ATLAS PHd Grants - We are excited to announce the creation of a dedicated grant scheme (thanks to a donation from Fabiola Gianotti and Peter Jenni following their award from the Fundamental Physics Prize foundation) to encourage young and high-caliber doctoral students in particle physics research (including computing for physics) and permit them to obtain world class exposure, supervision and training within the ATLAS collaboration. This special PhD Grant is aimed at graduate students preparing a doctoral thesis in particle physics (incl. computing for physics) to spend one year at CERN followed by one year support also at the home Institute.

  5. Muscular Dystrophy (MD)

    Science.gov (United States)

    ... Awards Enhancing Diversity Find People About NINDS NINDS Muscular Dystrophy Information Page Clinical Trials Finding the Optimum Regimen ... en Español Additional resources from MedlinePlus What is Muscular Dystrophy? The muscular dystrophies (MD) are a group of ...

  6. Collide and Squeeze MD

    CERN Document Server

    Gorzawski, Arkadiusz; Papotti, Giulia; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; Pieloni, Tatiana; CERN. Geneva. ATS Department

    2015-01-01

    Colliding the beams during the squeeze to profit from Landau damping due to head--on beam-beam and b* leveling are two operational modes that may have to be used in a not so distant future at the LHC. This MD aimed at improving the process control during the squeeze with much improved handling of reference for the orbit feedback system and at evaluating instruments and techniques to maintain the beam in collisions with active feedback on a good observable.

  7. Ph.D. shortage

    Science.gov (United States)

    The late 1990s will see a shortage of Ph.D. graduates, according to the Association of American Universities, Washington, D.C. AAU's new comprehensive study, “The Ph.D. Shortage: The Federal Role,” reports that competition for new Ph.D.s is already intense and can only intensify because demand is greater than supply in both academic and nonacademic markets.Doctoral education plays an increasingly important role in U.S. research and development programs. Students have a pivotal part in doing research and enriching it with new ideas. The AAU report says that graduate students are “major determinants of the creativity and productivity of U.S. academic research, the source of more than 50% of the nation's basic research.’ The market for doctoral education extends beyond the university. In 1985, about 43% of all Ph.D.s employed in this country were working outside higher education; the demand for doctorate recipients in nonacademic sectors continues to grow.

  8. Launching a Geoscience Career: Insights Gained from MS PHD'S Beyond the PhD

    Science.gov (United States)

    Guzman, W. I.; Johnson, A.; Williamson Whitney, V.; Jansma, P. E.; Huggans, M. J.; Ricciardi, L.

    2013-05-01

    The Beyond the PhD (B-PhD) Professional Development Program is the newest addition to the Minorities Striving and Pursuing Higher Degrees of Success (MS PHD'S®) Professional Development Program in Earth System Science. This exciting new program is designed to facilitate the development of a new community of underrepresented minority (URM) doctoral candidates and recent doctorate degree recipients in Earth system science (ESS)-related fields. Building upon MS PHD'S extensive professional development activities provided to URM undergraduate and graduate students, B-PhD's vision is to encourage and support URM doctoral students and early career PhD's in becoming part of the global workforce. (Since its inception in 2003, MSPHD'S supports 213 participants of which 42 have achieved the doctoral degree and another 71 are enrolled in doctoral programs.) By providing customized support and advocacy for participants, B-PhD facilitates smoother and informed transitions from graduate school to postdoctoral and tenure-track positions, as well as other "first" jobs in academia, government, industry, and non-profit organizations. In 2011, the first conference for 18 doctoral candidate and recent graduates was hosted at the University of Texas at Arlington's (UTA) College of Science. Using a format of guest speakers, brown bag discussions, and interactive breakout sessions, participants engaged in sessions entitled "Toolkits for Success in Academia, Business and Industry, Federal Government and Non-Profits", "Defining Short, Mid and Long Term Career Goals", "Accessing and Refining Skill Sets and Other Door Openers", "International Preparation and Opportunities", "Paying it Forward/Lifting as You Climb", and "Customized Strategies for Next Steps". This presentation will discuss outcomes from this pilot project, the use of social media to track and support ongoing B-PhD activities, and objectives for future B-PhD workshops.

  9. Industrial PhD report: Sustainable Innovation

    DEFF Research Database (Denmark)

    Olesen, Gitte Gylling Hammershøj

    2011-01-01

    Erhvervs PhD rapport udarbejdet i tilknytning til Erhvervs PhD kurset der er obligatorisk for Erhvervs PhD studerende. Rapporten omhandler relationer melllem den akademiske verden og industrien i sammenhæng med PhD projektet, betragtet og analyseret gennem teori om bæredygtig innovation.......Erhvervs PhD rapport udarbejdet i tilknytning til Erhvervs PhD kurset der er obligatorisk for Erhvervs PhD studerende. Rapporten omhandler relationer melllem den akademiske verden og industrien i sammenhæng med PhD projektet, betragtet og analyseret gennem teori om bæredygtig innovation....

  10. PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2003-12-01

    Full Text Available Report of PhD Dissertations. Guido Antonioli Conservator pacis et iustitie. La signoria di Taddeo Pepoli a Bologna (1337-1347, Tesi di dottorato di ricerca in Filologia romanza e cultura medievale (XIII ciclo, Università degli Studi di Bologna, 2001   Elisabetta Filippini «In vassallatico episcopi permanere debent». Rapporti vassallatici e concessioni beneficiali dei vescovi di Cremona fra X e XIII secolo, Tesi di dottorato di Ricerca in Storia Medievale (XV ciclo, Università Cattolica del Sacro Cuore di Milano, 2003   Marco Meschini, Innocenzo III e il "negotium pacis et fidei" in Linguadoca tra il 1198 e il 1215, Tesi di dottorato di ricerca in Storia medievale, Università Cattolica del Sacro Cuore, 2003   Fabrizio Ricciardelli The Politics of Exclusion in Florence (1215-1434, thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in History, University of Warwick, Department of History, April 2003 Renata Salvarani Baptizare pueros et decimas dare. Cura delle anime, strutturazione ecclesiastica e organizzazione delle campagne in area gardesana fra VIII e XIII secolo (diocesi di Brescia, Verona, Mantova e Trento, Tesi di dottorato in Storia medievale (XV ciclo, Università Cattolica del Sacro Cuore di Milano, 2002-2003   Vito Sibilio Le parole della prima crociata, Tesi di dottorato di ricerca in Storia dei centri delle vie e della cultura dei pellegrinaggi nel medioevo euromediterraneo, Università degli studi di Lecce, 2003

  11. ADT fast losses MD

    CERN Document Server

    Priebe, A; Dehning, B; Redaelli, S; Salvachua Ferrando, BM; Sapinski, M; Solfaroli Camillocci, M; Valuch, D

    2013-01-01

    The fast beam losses in the order of 1 ms are expected to be a potential major luminosity limitation for higher beam energies after the LHC long shutdown (LS1). Therefore a Quench Test is planned in the winter 2013 to estimate the quench limit in this timescale and revise the current models. This experiment was devoted to determination the LHC Transverse Damper (ADT) as a system for fast losses induction. A non-standard operation of the ADT was used to develop the beam oscillation instead of suppressing them. The sign flip method had allowed us to create the fast losses within several LHC turns at 450 GeV during the previous test (26th March 2012). Thus, the ADT could be potentially used for the studies of the UFO ("Unidentied Falling Object") impact on the cold magnets. Verification of the system capability and investigations of the disturbed beam properties were the main objectives of this MD. During the experiment, the pilot bunches of proton beam were excited independently in the horizontal and vertical ...

  12. MD5算法研究%MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    张裔智; 赵毅; 汤小斌

    2008-01-01

    随着网络技术的迅速发展,信息加密技术已成为保障网络安全的一种重要手段,加密算法已经成为人们的一个研究热点.本文对MD5算法进行了深入研究,介绍MD5算法的产生背景、应用及其算法流程,并提出了MD5算法的一个改进方案.

  13. 78 FR 14547 - Praxedes E. Alverez Santiago, M.D., Daniel Perez Brisebois, M.D., Jorge Grillasca Palou, M.D...

    Science.gov (United States)

    2013-03-06

    ... Praxedes E. Alverez Santiago, M.D., Daniel Perez Brisebois, M.D., Jorge Grillasca Palou, M.D., Rafael Garcia Nieves, M.D., Francis M. Vazques Roura, M.D., Angel B. Rivera Santos, M.D., Cosme D. Santos Torres, M.D., and Juan L. Vilaro Chardon, M.D.; Analysis of Agreement Containing Consent Order To Aid...

  14. Environmental impacts of brown coal surface mining and processing

    International Nuclear Information System (INIS)

    The proceedings contain 9 contributions, out of which 2 have been inputted in INIS. These are concerned with the impacts of mining in the North Bohemian Brown Coal Mining District on the air quality and public health, and with the effect of mined-out land reclamation on the environment. (M.D.). 8 tabs., 5 figs., 6 refs

  15. [Professor Andelko Wolf, MD, PhD. (1922-2007), eminent epidemiologist and dermatovenerologist].

    Science.gov (United States)

    Gruber, Franjo; Peris, Zdravko

    2009-01-01

    Professor Andelko Wolf graduated medicine from the University of Zagreb School of Medicine in 1947. First he specialised in epidemiology and became head of the Brucellosis Centre in Rijeka for the Istria region. Later he also specialised in dermatovenerology at the Department for Skin and Venereal diseases in Rijeka. He passed the specialty board exam in dermatovenerology in 1958 and became teaching assistant. In 1973, he became assistant professor and in 1981 full professor. At the Department he founded the Laboratory for Mycology and allergology. Later he focused on occupational skin diseases and photodermatology. His doctoral thesis was on the action of light on the skin. He chaired the Clinic and was a member of various Hospital and Medical School committees. He was an excellent clinician undergraduate and graduate student teacher in Rijeka and Zagreb. He published around eighty papers on dermatology, but also on the necessity to reform medical studies. PMID:20500011

  16. In Remembrance of Robert J. Arceci, M.D., Ph.D. | Office of Cancer Genomics

    Science.gov (United States)

    It is with great sadness and a profound sense of loss that OCG recognizes the untimely passing of Dr. Robert J. Arceci. Dr. Arceci was a co-Principal Investigator for the Acute Myeloid Leukemia (AML) project within the TARGET initiative, which aims to discover novel, more effective treatments for childhood cancers. Dr. Arceci was passionate about the use of cancer genomics to both inform therapeutic approaches in the clinic and expand the field of precision medicine.

  17. MD 751: Train Instability Threshold

    CERN Document Server

    Carver, Lee Robert; Metral, Elias; Salvant, Benoit; Levens, Tom; Nisbet, David; Zobov, M; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the octupole current thresholds for stability for a single bunch, and then make an immediate comparison (with the same operational settings) for a train of 72 bunches separated by 25ns. From theory, the expected thresholds should be similar. Any discrepancy between the two cases will be of great interest as it could indicate the presence of additional mechanisms that contribute to the instability threshold, for example electron cloud.

  18. Urbanism PhD Research 2008 - 2010

    NARCIS (Netherlands)

    Van der Hoeven, F.D.; Brand, N.; Van der Burg, L.; Çalışkan, O.; Tan, E.R.; Wang, C.-Y.; Zhou, J.

    2009-01-01

    To ensure the quality of the Ph.D. research the Department introduced a special procedure for periodic evaluation: after a period of nine months the potential Ph.D. candidates are asked to present their research design, theoretical framework and methodological approach to the members of the Departme

  19. Cavity Voltage Phase Modulation MD

    CERN Document Server

    Mastoridis, T; Butterworth, A; Molendijk, J; Tuckmantel, J

    2012-01-01

    The LHC RF/LLRF system is currently setup for extremely stable RF voltage to minimize transient beam loading eects. The present scheme cannot be extended beyond nominal beam current since the demanded power would push the klystrons to saturation. For beam currents above nominal (and possibly earlier), the cavity phase modulation by the beam will be not be corrected (transient beam loading), but the strong RF feedback and One-Turn Delay feedback will still be active for loop and beam stability in physics. To achieve this, the voltage set point will be adapted for each bunch. The goal of this MD was to test an iterative algorithm that would adjust the voltage set point to achieve the optimal phase modulation for klystron forward power considerations.

  20. Interaction in PhD supervision

    DEFF Research Database (Denmark)

    Kobayashi, Sofie; Grout, Brian William Wilson; Rump, Camilla Østerberg

    This paper contains an analysis of a single supervision session, undertaken with the aim of identifying how learning opportunities might be created for a PhD student. The supervision session concerned methodologies to be employed in a PhD study related to storm water management and included the Ph...... learning opportunity is created for the PhD student as a participant in the academic discussion with her supervisors about the research methodologies. The involvement of multiple supervisors appears to enrich the learning environment and help create learning opportunity....

  1. Atmospheres of Brown Dwarfs

    CERN Document Server

    Helling, Christiane

    2014-01-01

    Brown Dwarfs are the coolest class of stellar objects known to date. Our present perception is that Brown Dwarfs follow the principles of star formation, and that Brown Dwarfs share many characteristics with planets. Being the darkest and lowest mass stars known makes Brown Dwarfs also the coolest stars known. This has profound implication for their spectral fingerprints. Brown Dwarfs cover a range of effective temperatures which cause brown dwarfs atmospheres to be a sequence that gradually changes from a M-dwarf-like spectrum into a planet-like spectrum. This further implies that below an effective temperature of < 2800K, clouds form already in atmospheres of objects marking the boundary between M-Dwarfs and brown dwarfs. Recent developments have sparked the interest in plasma processes in such very cool atmospheres: sporadic and quiescent radio emission has been observed in combination with decaying Xray-activity indicators across the fully convective boundary.

  2. A workshop on leadership for senior MD-PhD students

    OpenAIRE

    Meador, Catherine B.; Parang, Bobak; Musser, Melissa A.; Haliyur, Rachana; Owens, David A.; Terence S Dermody

    2016-01-01

    Leadership skills are essential for a successful career as a physician-scientist, yet many MD–PhD training programs do not offer formal training in leadership. The Vanderbilt Medical Scientist Training Program (MSTP) previously established a 2-day leadership workshop that has been held biennially since 2006 for students in the first and second years of the graduate school portion of combined MD and PhD training (G1/G2 students). Workshop attendees have consistently rated this workshop as a hi...

  3. Brenda K. Edwards, PhD

    Science.gov (United States)

    Brenda K. Edwards, PhD, has been with the Surveillance Research Program (SRP) and its predecessor organizations at the National Cancer Institute (NCI) since 1989, serving as SRP’s Associate Director from 1990-2011.

  4. Biomedical PhD education - an international perspective

    DEFF Research Database (Denmark)

    Mulvany, Michael J.

    2013-01-01

    The PhD, otherwise known as the doctor of philosophy or Dr. Phil., is an internationally recognized degree, indicating that the PhD graduate has received training in research under supervision. Traditionally, the PhD was the route to an academic career, with most successful PhD graduates receivin...

  5. Protein engineering with PHD zinc fingers

    International Nuclear Information System (INIS)

    Full text: The plant homeodomain (PHD) is a protein domain of ∼45-100 residues that is characterised by a Cys4-His-Cys3 zinc-binding motif These domains are found widely in nuclear proteins involved in transcription and seem to have an array of functions. In some instances, PHD domains have been shown to be important in mediating protein-protein interactions. Sequence alignments indicate that while the cysteines, histidine and a few other key residues are strictly conserved, the rest of the domain can vary greatly in terms of both amino acid composition and length. Given the diversity of functions they fulfill in nature, we propose to use these PHD domains as prototype protein interaction scaffolds for drug design. We have determined the solution structure of the second PHD domain of Mi2 (Mi2-PHD2) by multi-dimensional NMR spectroscopy. The structure shows that Mi2-PHD2 adopts a globular fold in solution and contains a di-metal-binding structural motif with the two zinc ions ligated in an interleaved manner. While this structure is similar to that of other PHD domains, two flexible loop regions can also be observed. These loops may be suitable target regions for protein engineering studies, where novel binding functions could be introduced. To test the stability of the Mi2-PHD2 fold, we have made a number of mutations and insertions in the two loop regions NMR spectra of these mutants show they adopt native-like conformations. We are currently determining the structures of a selection of these mutants and are using a combination of rational and combinatorial methods to introduce new functions

  6. What PhD students really want

    CERN Document Server

    Mao, Minnie

    2010-01-01

    The road to becoming an astronomer is exciting, but often fraught with danger and conflicting messages. A PhD student is inundated with catch-phrases such as "publish or perish" and "it's not about the quantity, but the quality of work". How do we know which advice to follow? How can we publish copious amounts of quality work in only three years so as to maximize our success in the future? How do we even know what "good quality" really is? With only a short time to prepare ourselves for the big wide world of Astronomy, what is the best way for a PhD student to maximize their research and ultimately maximize their success as a real astronomer? The PhD students of today are the astronomers of tomorrow, but their journey depends on a positive work environment in which they can thrive and improve. Here I present the results of a survey of current PhD students on how they believe they can maximize their success in science. I find that PhD students in Australia expect to write more papers during their PhD than is e...

  7. Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer

    International Nuclear Information System (INIS)

    Colorectal cancer (CRC) is one of the most common and comprehensively studied malignancies. Hypoxic conditions during formation of CRC may support the development of more aggressive cancers. Hypoxia inducible factor (HIF), a major player in cancerous tissue adaptation to hypoxia, is negatively regulated by the family of prolyl hydroxylase enzymes (PHD1, PHD2, PHD3) and asparaginyl hydroxylase, called factor inhibiting HIF (FIH). PHD1, PHD2, PHD3 and FIH gene expression was evaluated using quantitative RT-PCR and western blotting in primary colonic adenocarcinoma and adjacent histopathologically unchanged colonic mucosa from patients who underwent radical surgical resection of the colon (n = 90), and the same methods were used for assessment of PHD3 gene expression in HCT116 and DLD-1 CRC cell lines. DNA methylation levels of the CpG island in the promoter regulatory region of PHD1, PHD2, PHD3 and FIH were assessed using bisulfite DNA sequencing and high resolution melting analysis (HRM) for patients and HRM analysis for CRC cell lines. We found significantly lower levels of PHD1, PHD2 and PHD3 transcripts (p = 0.00026; p < 0.00001; p < 0.00001) and proteins (p = 0.004164; p = 0.0071; p < 0.00001) in primary cancerous than in histopathologically unchanged tissues. Despite this, we did not observe statistically significant differences in FIH transcript levels between cancerous and histopathologically unchanged colorectal tissue, but we found a significantly increased level of FIH protein in CRC (p = 0.0169). The reduced PHD3 expression was correlated with significantly increased DNA methylation in the CpG island of the PHD3 promoter regulatory region (p < 0.0001). We did not observe DNA methylation in the CpG island of the PHD1, PHD2 or FIH promoter in cancerous and histopathologically unchanged colorectal tissue. We also showed that 5-Aza-2’-deoxycytidine induced DNA demethylation leading to increased PHD3 transcript and protein level in HCT116 cells. We

  8. Harvesting graphics power for MD simulations

    NARCIS (Netherlands)

    J.A. van Meel; A. Arnold; D. Frenkel; S.F. Portegies Zwart; R.G. Belleman

    2008-01-01

    We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a congruentia

  9. Fast Collision Attack on MD5

    NARCIS (Netherlands)

    Stevens, M.M.J.

    2006-01-01

    In this paper, we present an improved attack algorithm to find two-block collisions of the hash function MD5. The attack uses the same differential path of MD5 and the set of sufficient conditions that was presented by Wang et al. We present a new technique which allows us to deterministically fulfi

  10. Advances in Delta-md measurements

    OpenAIRE

    Ronga, Frederic Jean

    2003-01-01

    We report the current status of Delta-md measurements at B-factories. The most recent world average is Delta-md = 0.502+-0.007 1/ps (1.4% accuracy). An estimate of the errors for 500 1/fb data is also given.

  11. Brown Fat Cell Isolation

    OpenAIRE

    sprotocols

    2014-01-01

    Author: C.R. Kahn ### 1.) ISOLATION AND PRIMARY CULTURE OF BROWN FAT PREADIPOCYTES ### Rationale: To prepare primary brown preadipocytes for immortalization: useful for metabolic studies from knockout mice. This consists of the following five protocols. References: Fasshauer, M., J. Klein, K M. Kriauciunas, K. Ueki, M.Benito, and C.R. Kahn. 2001. Essential role of insulin substrate 1 in differentiation of brown adipocytes. *Mol Cell Biol* 21: 319-329. Fasshauer, M....

  12. Father Brown, Selected sories

    NARCIS (Netherlands)

    Chesterton, G.K.

    2005-01-01

    Father Brown, a small, round Catholic priest with a remarkable understanding of the criminal mind, is one of literature's most unusual and endearing detectives, able to solve the strangest crimes in a most fascinating manner. This collection draws from all five Father Brown books, and within their r

  13. Interview with Di Gao PhD

    Directory of Open Access Journals (Sweden)

    Di Gao

    2016-04-01

    Full Text Available Di Gao is currently a scientist in the Quality Control department of AstraZeneca. She is responsible for technology transfer, stability programs and supporting regulatory submission. She has a BSc and PhD degree in chemistry and interned with Genentech in 2012. After completing her Ph.D. from University of Michigan in June 2013, she joined the R&D department of the United States Pharmacopeia (USP to support USP monograph modernization and since June 2014 she has been working in her current position at AstraZeneca. Recently, she won a prestigious award from Women in Bio (WIB. WIB is an organization of professionals committed to promoting careers, leadership and entrepreneurship for women in the life sciences. This interview was conducted by Roland J.W. Meesters PhD, Editor-in-Chief of Journal of Applied Bioanalysis.

  14. Multi-Dimensional Games (MD-Games)

    OpenAIRE

    Ruiz Estrada, M.A.

    2009-01-01

    This paper introduces the concept of Multi-Dimensional games (MD-games) based on the application of an alternative mathematical and graphical modeling approach to study the game theory from a multi-dimensional perspective. In fact, the MD-Games request the application of the mega-space coordinate system to visualize a large number of games, players, strategies and pay-offs functions into the same graphical space.

  15. Interview with Di Gao PhD

    OpenAIRE

    Di Gao

    2016-01-01

    Di Gao is currently a scientist in the Quality Control department of AstraZeneca. She is responsible for technology transfer, stability programs and supporting regulatory submission. She has a BSc and PhD degree in chemistry and interned with Genentech in 2012. After completing her Ph.D. from University of Michigan in June 2013, she joined the R&D department of the United States Pharmacopeia (USP) to support USP monograph modernization and since June 2014 she has been working in her current p...

  16. Dichoptic perception of brown.

    Science.gov (United States)

    DeLawyer, Tanner; Morimoto, Takuma; Buck, Steven L

    2016-03-01

    Two experiments assessed mechanisms underlying brown induction by presenting a foveal target disk and concentric annular surround stimuli that varied in contrast relative to larger backgrounds. Stimuli were presented under monocular, binocular, and dichoptic viewing conditions. Observers adjusted the luminance of the target disk to a criterion brown level. We found evidence for at least two separate mechanisms for brown induction: one mechanism that is dependent on physically contiguous contrast and operates in monocular pathways and another mechanism that responds to high luminance contrast anywhere in the visual field and can operate after convergence of signals from the two eyes. PMID:26974916

  17. Gaussian Mixture PHD Filtering with Variable Probability of Detection

    OpenAIRE

    Hendeby, Gustaf; Karlsson, Rickard

    2014-01-01

    The probabilistic hypothesis density (PHD) filter has grown in popularity during the last decade as a way to address the multi-target tracking problem. Several algorithms exist; for instance under linear-Gaussian assumptions, the Gaussian mixture PHD (GM-PHD) filter. This paper extends the GM-PHD filter to the common case with variable probability of detection throughout the tracking volume. This allows for more efficient utilization, e.g., in situations with distance dependent probability of...

  18. MD5算法的分析和改进%Analysis and Improvement of .MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    么丽颖

    2011-01-01

    首先研究了MD5算法,并总结了MD5算法的特点及性能,在研究MD5算法的基础之上,提出了MD5改进加密算法.最后,对MD5算法与MD5改进算法对应于相关数据、性能进行了比较.%At first , MD5 algorithm is researched, and the characteristic and capability of the MD5 are summaried in the paper. The improved MD5 algorithm is put forward based on the research of the MDS. At last, the contrast between MD5 algorithm and the improved MD5 algorithm in related datum and capability are put forward.

  19. Detection of the bovine viral diarrhoea / mucosal disease (BVD/MD) virus in tissues from aborted ruminant foetuses using immunohistochemistry

    OpenAIRE

    S. M. Njiro; C.M. Nkosi

    2009-01-01

    Various tissues from aborted ruminant foetuses were collected, fixed in formalin and embedded in paraffin wax. Sections were made and exposed to a primary monoclonal antibody against the bovine viral diarrhoea / mucosal disease (BVD/MD) virus, and subsequently to a goat anti-mouse secondary antibody conjugated to horse radish peroxidase (HRP). Diaminobenzidine (DAB) was the substrate and it released a brown pigment in the tissues on reacting with the HRP in an immunohistochemistry (IHC) proce...

  20. Obituary: Beth Brown (1969-2008)

    Science.gov (United States)

    Bregman, Joel

    2011-12-01

    The astronomical community lost one of its most buoyant and caring individuals when Beth Brown died, unexpectedly, at the age of 39 from a pulmonary embolism. Beth Brown was born in Roanoke, Virginia where she developed a deep interest in astronomy, science, and science fiction (Star Trek). After graduating as the valedictorian of William Fleming High School's Class of 1987, she attended Howard University, where she graduated summa cum laude in 1991 with a bachelor's degree in astrophysics. Following a year in the graduate physics program at Howard, she entered the graduate program in the Department of Astronomy at the University of Michigan, the first African-American woman in the program. She received her PhD in 1998, working with X-ray observations of elliptical galaxies from the Röntgen Satellite (ROSAT; Joel Bregman was her advisor). She compiled and analyzed the first large complete sample of such galaxies with ROSAT and her papers in this area made an impact in the field. Following her PhD, Beth Brown held a National Academy of Science & National Research Council Postdoctoral Research Fellowship at NASA's Goddard Space Flight Center. Subsequently, she became a civil servant at the National Space Science Data Center at GSFC, where she was involved in data archival activities as well as education and outreach, a continuing passion in her life. In 2006, Brown became an Astrophysics Fellow at GSFC, during which time she worked as a visiting Assistant Professor at Howard University, where she taught and worked with students and faculty to improve the teaching observatory. At the time of her death, she was eagerly looking forward to a new position at GSFC as the Assistant Director for Science Communications and Higher Education. Beth Brown was a joyous individual who loved to work with people, especially in educating them about our remarkable field. Her warmth and openness was a great aid in making accessible explanations of otherwise daunting astrophysical

  1. Fast Collision Attack on MD5

    OpenAIRE

    Stevens, Marc

    2006-01-01

    In this paper, we present an improved attack algorithm to find two-block collisions of the hash function MD5. The attack uses the same differential path of MD5 and the set of sufficient conditions that was presented by Wang et al. We present a new technique which allows us to deterministically fulfill restrictions to properly rotate the differentials in the first round. We will present a new algorithm to find the first block and we will use an algorithm of Klima to find the second block. To o...

  2. Harvesting graphics power for MD simulations

    OpenAIRE

    Meel, van, C.S.; Arnold, A; Frenkel, D.; Portegies Zwart, S.F.; Belleman, R.G.

    2008-01-01

    We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a congruential shift random number generator are presented. The performance of the GPU’s is compared to their main processor counterpart. We achieve speedups of up to 40, 80 and 150 fold, respectively. With the...

  3. Harvesting graphics power for MD simulations

    OpenAIRE

    2008-01-01

    Abstract We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a congruential shift random number generator are presented. The performance of the GPU's is compared to their main processor counterpart. We achieve speedups of up to 80, 40 and 150 fold, re...

  4. ProtoMD: A Prototyping Toolkit for Multiscale Molecular Dynamics

    OpenAIRE

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2013-01-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates `GROMACS wrapper' to initiate MD simula...

  5. PhD students share their work

    CERN Multimedia

    Joannah Caborn Wengler

    2012-01-01

    Last week, the second Doctoral Student Assembly gave students in the final stages of their PhD at CERN the chance to meet and present their work.   On 9 May, 24 students who are completing their PhD under the CERN Doctoral Student Programme were joined by their CERN supervisors and some of their university supervisors at an event organised by HR and the Technical Students Committee (TSC). After an address by the Director-General Rolf Heuer and short presentations by Ingrid Haug from HR and TSC Chair Stephan Russenschuck, the students presented their work in a poster session. Held in a packed Council Chamber, the event was a great opportunity for the doctoral students to get to know each other and to share their work in fields as diverse as radiation protection, computing, physics and engineering.

  6. ATLAS PhD Grant Scholarship Programme

    CERN Multimedia

    Abha Eli Phoboo

    2014-01-01

    On 11 February, the first recipients of the ATLAS PhD Grant were presented with a certificate by the programme’s selection committee. The three scholars - Lailin Xu of China, Josefina Alconada of Argentina and Gagik Vardanyan of Armenia - were delighted at being able to continue their PhD programmes at CERN.   With certificates, from left: Lailin Xu, Josefina Alconada, and Gagik Vardanyan. The selection committee members, from left: IFAE Barcelona’s Martine Bosman, Fabiola Gianotti, Peter Jenni and from CERN HR James Purvis. (Image: ATLAS/Claudia Marcelloni). Former ATLAS spokespersons Peter Jenni and Fabiola Gianotti started the fund with the Fundamental Physics Prize award money they received last year. Both have used the entirety of their prizes for educational and humanitarian programmes. "We wanted to do something for students who are working on ATLAS, in particular those who otherwise could not come here and actually see the detector they are working on,&am...

  7. 2nd My phd International Conference

    OpenAIRE

    Armand Faganel

    2008-01-01

    The article presents the organization of the second My phd International Conference organized in June in Bratislava. The organizer Friedrich Ebert Foundation is a German non-profit organization. During the conference young researchers from various fields dealt with the issue of ‘New Europe’ and the challenges of sustainable development. The conference was also an opportunity for young researchers to meet new colleagues and exchange their views. The interest was very big since only 40 percent ...

  8. 78 FR 2707 - Maryland Disaster # MD-00026

    Science.gov (United States)

    2013-01-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Maryland Disaster MD-00026 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... INFORMATION CONTACT: A. Escobar, Office of Disaster Assistance, U.S. Small Business Administration, 409...

  9. Irradiated brown dwarfs

    CERN Document Server

    Casewell, S L; Lawrie, K A; Maxted, P F L; Dobbie, P D; Napiwotzki, R

    2014-01-01

    We have observed the post common envelope binary WD0137-349 in the near infrared $J$, $H$ and $K$ bands and have determined that the photometry varies on the system period (116 min). The amplitude of the variability increases with increasing wavelength, indicating that the brown dwarf in the system is likely being irradiated by its 16500 K white dwarf companion. The effect of the (primarily) UV irradiation on the brown dwarf atmosphere is unknown, but it is possible that stratospheric hazes are formed. It is also possible that the brown dwarf (an L-T transition object) itself is variable due to patchy cloud cover. Both these scenarios are discussed, and suggestions for further study are made.

  10. Fucoidans from brown seaweeds

    DEFF Research Database (Denmark)

    Ale, Marcel Tutor; Meyer, Anne S.

    2013-01-01

    -proliferative effects on cancer cells. Recent work has revealed distinct structural features of fucoidans obtained from different brown seaweed sources. Fucoidans are classically obtained from brown seaweeds by multi-step, hot acid extraction, but the structural and compositional traits, and possibly the bioactivity......Fucoidan or fucoidans cover a family of sulfated fucose-rich polysaccharides, built of a backbone of L-fucose units, and characteristically found in brown seaweeds. Fucoidans have potential therapeutic properties, including anti-inflammatory and anti-coagulant activities, as well as anti......, of the fucoidan polysaccharides are significantly influenced by the extraction parameters. This review discusses the structural features of fucoidans, the significance of different extraction technologies, and reviews enzymatic degradation of fucoidans and the use of fucoidan-modifying enzymes for...

  11. MD on UFOs at MKIs and MKQs

    CERN Document Server

    Baer, T; Bartmann, W; Bracco, C; Carlier, E; Dehning, B; Garrel, N; Goddard, B; Jackson, S; Jimenez, M; Kain, V; Mertens, V; Misiowiec, M; Nordt, A; Papotti, G; Uythoven, J; Wenninger, J; Zerlauth, M; Zamantzas, C; Zimmermann, F

    2012-01-01

    UFOs ("Unidentified Falling Objects") are expected to be one of the major known performance limitation of the LHC. In this MD, the production mechanism and the dynamics of UFOs at the injection kicker magnets (MKIs) and the tune kicker magnets (MKQs) were studied. This was done by pulsing the MKIs and MKQs on a gap in the partly filled machine. During the MD, in total 58 UFO-type beam loss patterns were observed directly after pulsing the MKIs. None were observed after pulsing the MKQs, which provides important input for possible mitigation strategies. The temporal and spatial distribution of the UFO events could be determined by using a dedicated BLM Study Buffer, the implications for the UFO dynamics are discussed.

  12. Batch By Batch Longitudinal Emittance Blowup MD

    CERN Document Server

    Mastoridis, T; Butterworth, A; Jaussi, M; Molendijk, J

    2012-01-01

    The transverse bunch emittance increases significantly at 450 GeV from the time of injection till the ramp due to IBS. By selectively blowing up the longitudinal emittance of the incoming batch at each injection, it should be possible to reduce the transverse emittance growth rates due to IBS. An MD was conducted on April 22nd 2012 to test the feasibility and performance of the batch-by-batch longitudinal emittance blowup. There were three main goals during the MD. First, to test the developed hardware, firmware, and software for the batch-by-batch blowup. Then, to measure the transverse emittance growth rates of blown-up and "witness" batches to quantify any improvement, and finally to test the ALLInjectSequencer class, which deals with the complicated gymnastics of introducing or masking the new batch to various RF loops.

  13. Integrative Medicine Program- MD Anderson Cancer Center

    OpenAIRE

    Lee, Richard T.

    2012-01-01

    The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integr...

  14. Ashley W. Oughterson, MD: Surgeon, Soldier, Leader

    OpenAIRE

    Kunstman, John W.; Longo, Walter E

    2015-01-01

    Ashley W. Oughterson, MD, (1895-1956) was a longtime faculty surgeon at Yale University. He performed some of the earliest pancreatic resections in the United States. During World War II, Colonel Oughterson was the primary “Surgical Consultant” in the South Pacific and present at nearly every major battle. His meticulously kept diary is regarded as the foremost source detailing wartime surgical care. Colonel Oughterson led the initial Army team to survey Hiroshima and Nagasaki following the n...

  15. The Reframing of Methodology: Revisiting a PhD Study

    OpenAIRE

    Sarah Dubberley

    2014-01-01

    The paper draws on a PhD study to explore some methodological dilemmas associated with the execution of qualitative research when framed within positivist study design. The PhD was linked to an externally funded research project which evaluated the implementation of a custody-based intervention in the secure estate. While the PhD was conceived as a qualitative study, informed by interpretivist methodology and associated epistemology, the wider funded study was informed by positivist tradition...

  16. Pursuit of the Ph.D.

    Directory of Open Access Journals (Sweden)

    Scott P. Kerlin

    1995-11-01

    Full Text Available he thesis is put forward that changes in public policy which originally promoted broad access to higher education are leading to the diminished likelihood that minorities, those from low-income backgrounds and females in underrepresented disciplines will pursue, or be able to complete, the doctorate. By reviewing a wide range of research literature and statistical reports on the status of doctoral education in the U.S. & Canada, a detailed sociological portrait of those who pursue the Ph.D. is presented. Recommendations are given for further research on doctoral education, particularly in areas of attrition,retention, student indebtedness, social stratification, and post-doctoral career plans.

  17. Understanding Non-Traditional PhD Students Habitus--Implications for PhD Programmes

    Science.gov (United States)

    Naidoo, Devika

    2015-01-01

    Against the background of vast changes in doctoral education and the emergence of non-traditional doctoral programmes, this paper investigates the habitus of non-traditional PhD students at a South African university. Bourdieu's conceptual tool of habitus informed the study. In-depth and open-ended interviews were conducted with 10 non-traditional…

  18. Janet Quinn, RN, PhD. Therapeutic touch and a healing way. Interview by Bonnie Horrigan.

    Science.gov (United States)

    Quinn, J

    1996-07-01

    Janet Quinn, RN, PhD, is an associate professor and senior scholar at the Center for Human Caring at the School of Nursing, University of Colorado Health Sciences Center, in Denver, Colo. In addition to teaching she conducts research, lectures, writes, and maintains a private practice in Boulder, Colo. She received her PhD in nursing research and theory development from New York University in 1982. Quinn is a member of Sigma Theta Tau, and is active in a diverse group of professional organizations including the American Nurses Association, American Holistic Nurses Association, Association for Holotropic Breathwork International, Association for Transpersonal Psychology, International Society for the Study of Subtle Energy and Energy Medicine, Hakomi Therapy Association, and the Institute of Noetic Sciences. During her career she has received many awards including the Healers Award from the Nurse Healers and Professional Associates (1995); the Edgar S Wilson, MD, Fellowship Award from the International Society for the Study of Subtle Energies and Energy Medicine (1994); and the Holistic Nurse of the Year award from the American Holistic Nurses Association. Alternative Therapies interviewed Dr Quinn at her office in Boulder, Colo. PMID:8795925

  19. 77 FR 73967 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-12-12

    ... Regulation; Bear Creek, Dundalk, MD'' in the Federal Register (77 FR 5201). The rulemaking concerned would... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD... highway bridge at Wise Avenue across Bear Creek, mile 3.4, between Dundalk and Sparrows Point, MD....

  20. Integrative Medicine Program- MD Anderson Cancer Center

    Directory of Open Access Journals (Sweden)

    Richard T Lee

    2012-06-01

    Full Text Available The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integrative Medicine Center provides clinical services to patients through individual and group programs.  The clinical philosophy of the center is to work collaboratively with the oncology teams to build comprehensive and integrative care plans that are personalized, evidence-based, and safe with the goal of improving clinical outcomes.  The individual services comprise of integrative oncology consultation, acupuncture, meditation, music therapy, nutrition, and oncology massage.  The center also provides a variety of group programs including meditation, yoga, tai chi, cooking classes and others.  Over the past 13 years, over 70,000 patients and families have participated in services and programs offered by the center.  The research portfolio focuses on three main areas: mind-body interventions, acupuncture, and meditation.  This lecture will focus on providing an overview of the Integrative Medicine Program at MD Anderson with a focus on the clinical services provided.  Participants will learn about the integrative clinical model and how this is applied to the care of cancer patients at MD Anderson Cancer Center.  Current and future research topics will be discussed as well as patient cases.

  1. Predicting Computer Science Ph.D. Completion: A Case Study

    Science.gov (United States)

    Cox, G. W.; Hughes, W. E., Jr.; Etzkorn, L. H.; Weisskopf, M. E.

    2009-01-01

    This paper presents the results of an analysis of indicators that can be used to predict whether a student will succeed in a Computer Science Ph.D. program. The analysis was conducted by studying the records of 75 students who have been in the Computer Science Ph.D. program of the University of Alabama in Huntsville. Seventy-seven variables were…

  2. Tracking the PhD Students' Daily Computer Use

    Science.gov (United States)

    Sim, Kwong Nui; van der Meer, Jacques

    2015-01-01

    This study investigated PhD students' computer activities in their daily research practice. Software that tracks computer usage (Manic Time) was installed on the computers of nine PhD students, who were at their early, mid and final stage in doing their doctoral research in four different discipline areas (Commerce, Humanities, Health Sciences and…

  3. Research Collaboration and Commercialization: The PhD Candidate Perspective

    Science.gov (United States)

    Dooley, Lawrence; Kenny, Breda

    2015-01-01

    This paper explores PhD students' perceptions of their entrepreneurial and commercial capabilities, their attitude towards university supports and the extent to which they engage in external collaboration. The study concentrated on current PhD researchers at one university in Ireland as a unit of analysis and provides encouraging evidence from the…

  4. MD Test of a Ballistic Optics

    CERN Document Server

    Garcia-Tabares Valdivieso, Ana; Salvachua Ferrando, Belen Maria; Skowronski, Piotr Krzysztof; Solfaroli Camillocci, Matteo; Tomas Garcia, Rogelio; Wenninger, Jorg; Coello De Portugal - Martinez Vazquez, Jaime Maria; CERN. Geneva. ATS Department

    2016-01-01

    The ballistic optics is designed to improve the understanding of optical errors and BPM systematic effects in the critical triplet region. The particularity of that optics is that the triplet is switched off, effectively transforming the triplets on both sides of IR1 and IR5 into drift spaces. Advantage can be taken from that fact to localize better errors in the Q4-Q5-triplet region. During this MD this new optics was tested for the first time at injection with beam 2.

  5. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    Science.gov (United States)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from github.com/CTCNano/proto_md.

  6. Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes.

    Science.gov (United States)

    Than, Aung; He, Hui Ling; Chua, Si Hui; Xu, Dan; Sun, Lei; Leow, Melvin Khee-Shing; Chen, Peng

    2015-06-01

    Brown adipose tissue expends energy in the form of heat via the mitochondrial uncoupling protein UCP1. Recent studies showed that brown adipose tissue is present in adult humans and may be exploited for its anti-obesity and anti-diabetes actions. Apelin is an adipocyte-derived hormone that plays important roles in energy metabolism. Here, we report that apelin-APJ signaling promotes brown adipocyte differentiation by increasing the expressions of brown adipogenic and thermogenic transcriptional factors via the PI3K/Akt and AMPK signaling pathways. It is also found that apelin relieves the TNFα inhibition on brown adipogenesis. In addition, apelin increases the basal activity of brown adipocytes, as evidenced by the increased PGC1α and UCP1 expressions, mitochondrial biogenesis, and oxygen consumption. Finally, we provide both in vitro and in vivo evidence that apelin is able to increase the brown-like characteristics in white adipocytes. This study, for the first time, reveals the brown adipogenic and browning effects of apelin and suggests a potential therapeutic route to combat obesity and related metabolic disorders. PMID:25931124

  7. A workshop on leadership for senior MD-PhD students.

    Science.gov (United States)

    Meador, Catherine B; Parang, Bobak; Musser, Melissa A; Haliyur, Rachana; Owens, David A; Dermody, Terence S

    2016-01-01

    Leadership skills are essential for a successful career as a physician-scientist, yet many MD-PhD training programs do not offer formal training in leadership. The Vanderbilt Medical Scientist Training Program (MSTP) previously established a 2-day leadership workshop that has been held biennially since 2006 for students in the first and second years of the graduate school portion of combined MD and PhD training (G1/G2 students). Workshop attendees have consistently rated this workshop as a highly effective experience. However, opportunities for structured training in leadership competencies during the subsequent 3-5 years of MD-PhD training are limited. Given the success of the G1/G2 leadership workshop and the need for continuity in this model of leadership training, we developed a half-day workshop for MSTP students in the clinical years of medical school (M3/M4 students) to foster continued training in leadership. Our workshop curriculum, based in part on original cases drafted by Vanderbilt MSTP students, provides concrete strategies to manage conflict and navigate leadership transitions in the physician-scientist career path. The curriculum emphasizes both short-term competencies, such as effective participation as a member of a clinical team, and long-term competencies, such as leadership of a research team, division, or department. Our inaugural senior leadership workshop, held in August, 2015, was judged by student participants to be well organized and highly relevant to leadership concepts and skills. It will be offered biennially in our training curriculum for M3 and M4 MSTP students. PMID:27499363

  8. Ante Šiljeg, PhD in Interdisciplinary Sciences

    Directory of Open Access Journals (Sweden)

    Sanja Lozić

    2013-12-01

    Full Text Available Ante Šiljeg defended his doctoral thesis The Digital Relief Model in Analysis of Geomorphometric Parameters – Example of PP Vrana Lake at Faculty of Science, University of Zagreb on June 20th, 2013 (supervisor Sanja Lozić, PhD, assistant professor and received a PhD degree in the field of interdisciplinary science, field of geography, branch of applied geography. Doctoral thesis was defended in front of committee composed of Mladen Pahernik, PhD, assistant professor, Danijel Orešić, PhD, associate professor and Aleksandar Toskić, PhD, associate professor. Commitee for disertation review was in the same composition.

  9. 2. mednarodna konferenca My PhD = 2nd My phd International Conference

    OpenAIRE

    Armand Faganel

    2008-01-01

    The article presents the organization of the second My phd InternationalConference organized in June in Bratislava. The organizer Friedrich Ebert Foundation is a German non-profit organization. During the conference young researchers from various fields dealt with the issue of ‘New Europe’ and the challenges of sustainable development. The conference was also an opportunity for young researchers to meet new colleagues and exchange their views. The interest was very big since only 40 percent o...

  10. 75 FR 69862 - Airworthiness Directives; MD Helicopters, Inc. Model MD900 Helicopters

    Science.gov (United States)

    2010-11-16

    ... exist or develop on other helicopters of the same type design. Therefore, this AD requires, within 4...-AD. Applicability: Model MD900 helicopters, with lower main rotor hub (hub), part number 900R2101008... the main rotor hub (hub) for a crack. If a crack is found, this AD requires, before further...

  11. 76 FR 41662 - Airworthiness Directives; MD Helicopters, Inc. Model MD900 Helicopters

    Science.gov (United States)

    2011-07-15

    ... helicopters of this same type design. AD Requirements This AD requires a visual inspection, and if necessary...) Inspect the main rotor lower hub assembly for a crack by following the specified portions of MD Helicopter... rotor lower hub assembly (lower hub) for a crack, and if you find a crack, before further...

  12. 76 FR 1993 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Science.gov (United States)

    2011-01-12

    ... (75 FR 34661). That NPRM proposed to require installing fuel level float and pressure switch in-line... 12866, (2) Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034... Maintenance Manual (AMM) defueling procedure MD80 AMM 12-13-00. The correct reference is Boeing MD80 AMM...

  13. Detection of the bovine viral diarrhoea / mucosal disease (BVD/MD virus in tissues from aborted ruminant foetuses using immunohistochemistry

    Directory of Open Access Journals (Sweden)

    S.M. Njiro

    2009-05-01

    Full Text Available Various tissues from aborted ruminant foetuses were collected, fixed in formalin and embedded in paraffin wax. Sections were made and exposed to a primary monoclonal antibody against the bovine viral diarrhoea / mucosal disease (BVD/MD virus, and subsequently to a goat anti-mouse secondary antibody conjugated to horse radish peroxidase (HRP. Diaminobenzidine (DAB was the substrate and it released a brown pigment in the tissues on reacting with the HRP in an immunohistochemistry (IHC procedure. Of 27 aborted foetuses, an immunoperoxidase staining reaction was observed in 1 ovine and 5 bovine foetuses. The IHC procedure located BVD/MD viral antigen in a wide variety of foetal tissues including cerebral cortical neurons, the pseudostratified columnar epithelial cells lining the bronchi, alveolar lining cells and alveolar macrophages, hepatocytes, renal tubular lining cells and the Purkinje fibres in the myocardium.

  14. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    Science.gov (United States)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from

  15. Tune Your Brown Clustering, Please

    DEFF Research Database (Denmark)

    Derczynski, Leon; Chester, Sean; Bøgh, Kenneth Sejdenfaden

    2015-01-01

    Brown clustering, an unsupervised hierarchical clustering technique based on ngram mutual information, has proven useful in many NLP applications. However, most uses of Brown clustering employ the same default configuration; the appropriateness of this configuration has gone predominantly...... unexplored. Accordingly, we present information for practitioners on the behaviour of Brown clustering in order to assist hyper-parametre tuning, in the form of a theoretical model of Brown clustering utility. This model is then evaluated empirically in two sequence labelling tasks over two text types. We...... explore the dynamic between the input corpus size, chosen number of classes, and quality of the resulting clusters, which has an impact for any approach using Brown clustering. In every scenario that we examine, our results reveal that the values most commonly used for the clustering are sub-optimal....

  16. 2. mednarodna konferenca My PhD = 2nd My phd International Conference

    Directory of Open Access Journals (Sweden)

    Armand Faganel

    2008-09-01

    Full Text Available The article presents the organization of the second My phd InternationalConference organized in June in Bratislava. The organizer Friedrich Ebert Foundation is a German non-profit organization. During the conference young researchers from various fields dealt with the issue of ‘New Europe’ and the challenges of sustainable development. The conference was also an opportunity for young researchers to meet new colleagues and exchange their views. The interest was very big since only 40 percent of the applicants were accepted. Another interesting thing was the competitive approach towards the conference, which means that only the best articles will be published in the conference proceedings.

  17. Ecological Agriculture Research: Increasing Competence through PhD Courses.

    Science.gov (United States)

    Lieblein, G.; Francis, C. A.; Salomonsson, L.; Sriskandarajah, N.

    1999-01-01

    A Ph.D. course in ecological agriculture included a weeklong intensive workshop and individual research projects. The course demonstrated the usefulness of multiple approaches to learning research methods and perspectives and increased networking among researchers. (SK)

  18. A Gaussian Mixture PHD Filter for Extended Target Tracking

    OpenAIRE

    Granström, Karl; Lundquist, Christian; Orguner, Umut

    2010-01-01

    In extended target tracking, targets potentially produce more than one measurement per time step. Multiple extended targets are therefore usually hard to track, due to the resulting complex data association. The main contribution of this paper is the implementation of a Probability Hypothesis Density (PHD) filter for tracking of multiple extended targets. A general modification of the PHD filter to handle extended targets has been presented recently by Mahler, and the novelty in this work lie...

  19. Information behaviour and practices of PhD students

    OpenAIRE

    Drachen, Thea Marie; Larsen, Asger Væring; Gullbekk, Eystein; Westbye, Hilde; Lach, Karin

    2011-01-01

    This report addresses the information behaviour and practices of PhD students and its implications for library services. Academic libraries and their services are part of the information network of PhD students. Therefore libraries should pay special attention to the needs and practices of this important academic subgroup. The University Librarian at Copenhagen University Library and Information Service (CULIS) commissioned this study. It was conducted by representatives from CULIS, Universit...

  20. Making data in PhD dissertations reusable for research

    OpenAIRE

    Schöpfel, Joachim; Prost, Hélène; Malleret, Cécile

    2015-01-01

    How can an academic library contribute to make data submitted together with PhD dissertations useful for further research? Our paper provides some recommendations for information professionals, based on a review of studies and projects and on empirical evidence from a content analysis of data sources and types from 300 print and digital dissertations in social sciences and humanities (1987-2013) and a survey on data management conducted with the scientists and PhD students of the University o...

  1. 78 FR 35773 - Airworthiness Directives; MD Helicopters, Inc. (MDHI), Helicopters

    Science.gov (United States)

    2013-06-14

    ... the MDHI Model MD900 helicopters with certain main rotor blade (MRB) retention bolts (bolts) installed... MD 900 helicopters with a main rotor blade retention bolt (bolt), part number (P/N) 900R3100001-103... exist or develop on other products of the same type design. Related Service Information We have...

  2. MD290: Q4 IP6 Quench Level

    CERN Document Server

    Bednarek, Mateusz Jakub; Lechner, Anton; CERN. Geneva. ATS Department

    2016-01-01

    The detailed program proposed for the LHC Machine Development concerning a quench induced by fast losses on the MQY.4L6 quadrupole is presented. The merit of the MD, the necessary modifications of the machine protection systems are presented together with a preliminary analysis of the MD results.

  3. 77 FR 5201 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-02-02

    ... Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public meeting. But you may... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD... across Bear Creek, mile 3.4, between Dundalk and Sparrows Point, MD. The proposed change will alter...

  4. Single-block collision attack on MD5

    NARCIS (Netherlands)

    Stevens, M.M.J.

    2012-01-01

    In 2010, Tao Xie and Dengguo Feng \\cite{cryptoeprint:2010:643} constructed the first single-block collision for MD5 consisting of two 64-byte messages that have the same MD5 hash. Details of their attack, developed using what they call an evolutionary approach, has not been disclosed ``for security

  5. 76 FR 51887 - Safety Zone; Patuxent River, Patuxent River, MD

    Science.gov (United States)

    2011-08-19

    ...) entitled ``Safety Zone; Patuxent River, Patuxent River, MD'' in the Federal Register (76 FR 36447). We... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY... safety zone during the ``NAS Patuxent River Air Expo '11,'' which consists of aerial...

  6. Chosen-Prefix Collisions for MD5 and Applications

    NARCIS (Netherlands)

    Stevens, M.M.J.; Lenstra, A.K.; Weger, B. de

    2012-01-01

    We present a novel, automated way to find differential paths for MD5. Its main application is in the construction of \\emph{chosen-prefix collisions}. We have shown how, at an approximate expected cost of $2^{39}$ calls to the MD5 compression function, for any two chosen message prefixes $P$ and $P'$

  7. DFT-MD simulations of shocked Xenon

    Science.gov (United States)

    Magyar, Rudolph J.; Mattsson, Thomas R.

    2009-03-01

    Xenon is not only a technologically important element used in laser technologies, jet propulsion and dental anesthesia, but it is also arguably the simplest material in which to study the metal-insulator transition at high pressure. Because of its closed shell electronic configuration, Xenon is often assumed to be chemically inert, interacting almost entirely through the van der Waals interaction, and at liquid density, is typically modeled well using Leonard-Jones potentials. However, such modeling has a limited range of validity as Xenon is known to form compounds at normal conditions and likely exhibits considerably more chemistry at higher densities when hybridization of occupied orbitals becomes significant. In this talk, we present DFT-MD simulations of shocked liquid Xenon with the goal of developing an improved equation of state. The relative importance of the van der Waals interaction compared to other Coulomb interactions is considered, and estimates of the relative accuracy of various density functionals are quantified. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  8. Brown coal and the climate

    International Nuclear Information System (INIS)

    The undisputed aims of a sensible energy policy are safety, reasonable prices, environmental compatibility and saving resources. Each energy source and every form of energy conversion and use has specific advantages and disadvantages which must be weighed up. It is in favour of brown coal that it can succeed in international competition and therefore offers security of supply, economy, productivity and employment. The mining and use of brown coal comply with the highest environmental standards, in international comparison. Against this, mining brown coal by strip mining inevitably involves intervention in the environment and the social structure of the coalfield. Burning brown coal to generate electricity in powerstations is specifically connected with high CO2 emission. (orig.)

  9. The Production Rate and Employment of Ph.D. Astronomers

    Science.gov (United States)

    Metcalfe, Travis S.

    2008-02-01

    In an effort to encourage self-regulation of the astronomy job market, I examine the supply of, and demand for, astronomers over time. On the supply side, I document the production rate of Ph.D. astronomers from 1970 to 2006 using the UMI Dissertation Abstracts database, along with data from other independent sources. I compare the long-term trends in Ph.D. production with federal astronomy research funding over the same time period, and I demonstrate that additional funding is correlated with higher subsequent Ph.D. production. On the demand side, I monitor the changing patterns of employment using statistics about the number and types of jobs advertised in the AAS Job Register from 1984 to 2006. Finally, I assess the sustainability of the job market by normalizing this demand by the annual Ph.D. production. The most recent data suggest that there are now annual advertisements for about one postdoctoral job, half a faculty job, and half a research/support position for every new domestic Ph.D. recipient in astronomy and astrophysics. The average new astronomer might expect to hold up to 3 jobs before finding a steady position.

  10. Cubature Information SMC-PHD for Multi-Target Tracking.

    Science.gov (United States)

    Liu, Zhe; Wang, Zulin; Xu, Mai

    2016-01-01

    In multi-target tracking, the key problem lies in estimating the number and states of individual targets, in which the challenge is the time-varying multi-target numbers and states. Recently, several multi-target tracking approaches, based on the sequential Monte Carlo probability hypothesis density (SMC-PHD) filter, have been presented to solve such a problem. However, most of these approaches select the transition density as the importance sampling (IS) function, which is inefficient in a nonlinear scenario. To enhance the performance of the conventional SMC-PHD filter, we propose in this paper two approaches using the cubature information filter (CIF) for multi-target tracking. More specifically, we first apply the posterior intensity as the IS function. Then, we propose to utilize the CIF algorithm with a gating method to calculate the IS function, namely CISMC-PHD approach. Meanwhile, a fast implementation of the CISMC-PHD approach is proposed, which clusters the particles into several groups according to the Gaussian mixture components. With the constructed components, the IS function is approximated instead of particles. As a result, the computational complexity of the CISMC-PHD approach can be significantly reduced. The simulation results demonstrate the effectiveness of our approaches. PMID:27171088

  11. The Production Rate and Employment of Ph.D. Astronomers

    CERN Document Server

    Metcalfe, Travis S

    2007-01-01

    In an effort to promote self-regulation of the astronomy job market, I examine the supply of, and demand for, astronomers over time. On the supply side, I document the production rate of Ph.D. astronomers from 1970 to 2006 using the UMI Dissertation Abstracts database, along with data from other independent sources. I compare the long-term trends in Ph.D. production with federal astronomy research funding over the same time period, and I demonstrate that additional funding is correlated with higher subsequent Ph.D. production. On the demand side, I monitor the changing patterns of employment using statistics about the number and types of jobs advertised in the AAS Job Register from 1984 to 2006. Finally, I assess the sustainability of the job market by normalizing this demand by the annual Ph.D. production. The most recent data suggest that there are now annual advertisements for about one postdoctoral job, half a faculty job, and half a research/support position for every new domestic Ph.D. recipient in astr...

  12. The Achromatic Telescopic Squeezing (ATS) MD part III

    CERN Document Server

    Fartoukh, S; Goddard, B; Hofle, W; Jacquet, D; Kruk, G; Lamont, M; de Maria, R; Miyamoto, R; Mueller, G; Pojer, M; Ponce, L; Redaelli, S; Ryckx, N; Steinhagen, R; Strzelczyk, M; Vanbavinckhove, G; Wenninger, J

    2011-01-01

    This note highlights the results obtained during the third so-called ATS MD which took place in 2011. The goal of this MD was extremely challenging, targeting a pre-squeezed beta* of 40 cm in ATLAS and CMS, followed by a telescopic squeeze of these two insertions to finally reach a beta* of 10 cm both at IP1 and IP5. Due to the rather poor machine availability during the MD period, the time initially allocated to the ATS studies was hardly cut by a factor of 2, and "only" the achromatic pre-squeeze down to beta*=40 cm was demonstrated with beam.

  13. Single-block collision attack on MD5

    OpenAIRE

    Stevens, Marc

    2012-01-01

    In 2010, Tao Xie and Dengguo Feng \\cite{cryptoeprint:2010:643} constructed the first single-block collision for MD5 consisting of two 64-byte messages that have the same MD5 hash. Details of their attack, developed using what they call an evolutionary approach, has not been disclosed ``for security reasons''. Instead they have posted a challenge to the cryptology community to find a new different single-block collision attack for MD5. This paper answers that challenge by presenting a single-b...

  14. MD 239 on Collide and Squeeze (part 2)

    CERN Document Server

    Gorzawski, Arkadiusz; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; CERN. Geneva. ATS Department

    2016-01-01

    Colliding the beams during the squeeze to profit from Landau damping due to head--on beam-beam and beta--star leveling are two operational modes that may have to be used in a not so distant future at the LHC. This MD aimed at improving the orbit control during the squeeze with much improved handling of orbit feedback references and at evaluating instruments and techniques to maintain the beam in collisions with active feedback on luminosity or beam position. This MD also integrated for the first time synchronized collimator measurements. Comparison of the settings with the previous MD allowed a validation of the long term stability of collide and squeeze.

  15. Charge separation reaction in clusters of polar molecules. MD simulations

    International Nuclear Information System (INIS)

    Rate constant of intermolecular electron transfer (ET) in a photoexcited donor-acceptor model system solvated by a cluster of polar molecules has been expressed in terms of the statistical distribution of the electrostatic potential energy difference between the reacting sites. This distribution has been calculated for a particular case of acetonitrile clusters at ∼ 120 K by MD computer simulation. The MD values of the cluster reorganization energy and the ET rate constant have been compared with the corresponding MD results for the donor-acceptor pair solvated in bulk acetonitrile and with theoretical predictions based on the continuum model. (author)

  16. MD5Hash加密算法在SQL Server2005中的应用%Application of MD5 Hash Encryption Algorithm in SQL Server 2005

    Institute of Scientific and Technical Information of China (English)

    李红日

    2011-01-01

    在对MD5算法进行简要描述的同时,对MD5算法的原理作深入分析.介绍在C创建MD5 Hash算法的函数,在SQL Server中应用MD5哈希算法,并且经过测试可以准确实现MD5 Hash加密算法.

  17. Cryptanalysis of the Hash Function MD5%关于Hash函数MD5的解析

    Institute of Scientific and Technical Information of China (English)

    毛明; 陈少晖; 袁征; 贾永兴

    2009-01-01

    This paper is about the cryptanalysis of the Hash function MDS, on the basis of the paper concerning the breaking the MD5 which was written by Wang et al.In this paper,the eighth step of MD5 algorithm was taken for exam-ple and the properties of the F function and the effective control of the differential path were introduced.The MD5 algo-rithm was cryptanalyzed from both the manual calculation and the testing program and some part of the paper written by Wang was amended.Finally, the conditions and key points of meeting the differential characteristics were discussed.In general, this paper plays an important role in eryptanalyzing and breaking the MD5 algorithm.%在王小云写的关于分析MD5算法文章的基础上,对MD5算法的破译进行进一步的解析.以MD5算法第八步为例,介绍了F函数的性质和差分路径的有效控制.从手工推算和程序实现两方面时MD5算法进行了解析和测试,对王的文章进行了部分修正,进一步说明了满足差分特征的条件和关键点.这对MD5和其他Hash函数的分析破译有着重要的作用.

  18. An analysis of Ph.D. examiners' reports in engineering

    Science.gov (United States)

    Prieto, Elena; Holbrook, Allyson; Bourke, Sid

    2016-03-01

    In recent years, there have been increasing calls for an overall transformation of the nature of engineering Ph.D. programs and the way theses are assessed. There exists a need to understand the examination process to ensure the best quality outcome for candidates in engineering. The work we present in this paper uses data collected between 2003 and 2010 for a total of 1220 Australian Ph.D. theses by analysing examiner reports. Our analysis indicates that Ph.D. theses in engineering, N = 106, differ considerably from those in other fields in areas such as gender of candidates and examiners and the examiners' geographical location. We also found that assessment areas such as significance and contribution of the thesis, publications arising from the thesis, breadth, depth and recency of the literature review and communication and editorial correctness are areas in which the proportion of text of engineering examiners' comments differs significantly from other fields.

  19. Waiting time distribution in M/D/1 queueing systems

    DEFF Research Database (Denmark)

    Iversen, Villy Bæk; Staalhagen, Lars

    1999-01-01

    The well-known formula for the waiting time distribution of M/D/1 queueing systems is numerically unsuitable when the load is close to 1.0 and/or the results for a large waiting time are required. An algorithm for any load and waiting time is presented, based on the state probabilities of M/D/1....... The principles are also applicable for other queueing systems...

  20. Autentikasi Pesan Menggunakan Algoritma Message Digest 5 (MD5)

    OpenAIRE

    Simamora, Ali Makmur

    2015-01-01

    When receive or send a message on the network internet, there are some issue which very important namely problem wholeness and authentication. This script discusses about authentication of message with Message Digest algorithm 5. The writter designed an application to ensure the integrity of the message by algorithm MD5. MD5 is a tool to declare the validity of (authentic) sent messages as well as message. To express validity of message in the text or file will used encryption method, so the ...

  1. The Production Rate and Employment of Ph.D. Astronomers

    OpenAIRE

    Metcalfe, Travis S.

    2007-01-01

    In an effort to encourage self-regulation of the astronomy job market, I examine the supply of, and demand for, astronomers over time. On the supply side, I document the production rate of Ph.D. astronomers from 1970 to 2006 using the UMI Dissertation Abstracts database, along with data from other independent sources. I compare the long-term trends in Ph.D. production with federal astronomy research funding over the same time period, and I demonstrate that additional funding is correlated wit...

  2. Proceedings of the ICTSS 2012 PhD Workshop - Preface

    DEFF Research Database (Denmark)

    Nielsen, Brian; Weise, Carsten

    2012-01-01

    their thesis work and receive constructive feedback from experts in the field as well as from peers. Also it is an opportunity for researchers to get an insight into new research topics in the field. Ph.D. students at any stage of their doctoral studies may participate. Seven abstracts were submitted......, theoretic, and practical challenges of testing software systems, including communication protocols, services, distributed platforms, middleware, embedded systems, and security infrastructures. The aims of the ICTSS Doctoral Workshop is to provide a forum for PhD students to present preliminary results and...

  3. PhD Thesis: Functional Textiles in Hospital Interiors

    DEFF Research Database (Denmark)

    Mogensen, Jeppe Emil

    The PhD thesis explores the possibilities and design qualities of using functional textiles in the interior of hospital environments, and is the result of a three-year collaboration between Aalborg University, Department of Civil Engineering, and VIA University College, VIA Design. The thesis...... main design qualities that may improve the patients’ experience of the hospital interior, and in the experimental studies these aesthetic quali- ties are contextualised in empirical studies conducted at two Danish hospitals. Through these different studies, the PhD thesis addresses the technical and...

  4. Research of the Hash Algorithm Based on MD5%MD5散列算法的研究

    Institute of Scientific and Technical Information of China (English)

    姜学军; 曹烨

    2014-01-01

    借鉴了M.M.J.Stevens的碰撞思路,重新编写了MD5碰撞算法中的核心循环,主要提供一对MD5碰撞产生的过程以及碰撞的完成.通过实验统计分析,利用改进的MD5碰撞算法找到一对碰撞信息所用平均时间不多于60s,且该算法较之传统的MD5碰撞算法具有更好的可读性和可移植性.

  5. Postharvest internal browning of pineapple fruit originates at the phloem.

    Science.gov (United States)

    Luengwilai, Kietsuda; Beckles, Diane M; Siriphanich, Jingtair

    2016-09-01

    A typical symptom of postharvest chilling injury (PCI) in pineapple fruit (Ananas comosus (L.) Merr.) is internal browning (IB) near the fruit core. Since vascular bundles (VBs) are localized to this region, it was hypothesized that the VBs might be the site of IB. To test this, the anatomy and histochemistry of VBs during chilling stress in four pineapple cultivars with different levels of sensitivity to PCI were examined. Fruit were stored at 10°C for up to three weeks to stimulate translucency symptoms (TS; the initiation of IB). After three weeks of chilling exposure, the cultivars 'MD2' showed 0%, 'Pattavia' and 'Savee' showed 10-16%, and 'Trad Sri Thong' showed 100% TS and IB symptom. Scanning electron microscopy and in situ histochemical staining techniques that detect enzymes and substrates commonly associated with IB initiation were used in parallel. The TS of pineapple fruit coincided with the collapse of the phloem tissue. The VBs in the tissue where IB was initiated (i.e., the flesh adjacent to the core or F/C) had the highest activity of polyphenol oxidase, hydrogen peroxide, and phenolic compounds. The IB-resistant 'MD2' genotype had fewer VBs, but a greater proportion of sclerenchyma fibers (P<0.05) than did the susceptible 'Trad Sri Thong'. Based on these data, the first report of pineapple IB occurrence in the phloem was proposed. PMID:27517640

  6. Live-trapping and handling brown bear

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This paper reports techniques developed to live trap and handle brown bears on the Kodiak National Wildlife Refuge. The brown bears (Ursus middendorffi) on the...

  7. Browns Park NWR Water Use Report- 1999

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 1999. A basic introduction highlighting the region that Browns Park NWR is a part of and the...

  8. Browns Park NWR Water Use Report- 2000

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 2000. A basic introduction highlighting the region that Browns Park NWR is a part of and the...

  9. Ph.D Afhandling: Restaurering verus instaurering og transstaurering

    DEFF Research Database (Denmark)

    Bech-Nielsen, Grith

    2012-01-01

    Ph.d. afhandlingen udforsker holdningen som arkitektfagligt instrument. Fagudøverens "holdning" til værdisætning af arkitektoniske kulturarvsobjekter og til arkitektonisk intervention heri fungerer aktuelt som et anerkendt og konstituerende beslutningsinstrument i praksisnære processer og sammenh...

  10. An Analysis of Ph.D. Examiners' Reports in Engineering

    Science.gov (United States)

    Prieto, Elena; Holbrook, Allyson; Bourke, Sid

    2016-01-01

    In recent years, there have been increasing calls for an overall transformation of the nature of engineering Ph.D. programs and the way theses are assessed. There exists a need to understand the examination process to ensure the best quality outcome for candidates in engineering. The work we present in this paper uses data collected between 2003…

  11. Measures for Ph.D. Evaluation: The Recruitment Process

    Science.gov (United States)

    D'Agostino, Antonella; Fruzzetti, Stefania; Ghellini, Giulio; Neri, Laura

    2011-01-01

    In the last years the quality of Higher Education (HE) system and its evaluation have been key issues of the political and scientific debate on education policies all over Europe. In the wide landscape that involves the entire HE system we draw attention on the third level of its organization, i.e. the Ph.D. In particular, this paper discusses the…

  12. Ph.d. report nº1

    DEFF Research Database (Denmark)

    Hernandez, Lorenzo Banos

    The following report serves as an introduction to the Ph.d subject "Control system Modeling of the Wave Star Energy's Power Take-O". The device studied belongs to the Wave Energy field, which forms part of the renewable hydro Power generation sector. In Denmark, following the succesful course of...

  13. PhD by Publication: A Student's Perspective

    Directory of Open Access Journals (Sweden)

    Peter Kanowski

    2008-01-01

    Full Text Available This article presents the first author's experiences as an Australian doctoral student undertaking a PhD by publication in the arena of the social sciences. She published nine articles in refereed journals and a peer-reviewed book chapter during the course of her PhD. We situate this experience in the context of current discussion about doctoral publication practices, in order to inform both postgraduate students and academics in general. The article discusses recent thinking about PhD by publication and identifies the factors that students should consider prior to adopting this approach, in terms of university requirements, supervisors' attitudes, the research subject matter, intellectual property, capacity and working style, and issues of co-authorship. It then outlines our perceptions of the advantages and disadvantages of undertaking a PhD by publication. We suggest that, in general, the advantages outweigh the disadvantages. We conclude by reflecting on how the first author's experiences relate to current discussions about fostering publications by doctoral students.

  14. The Production Rate and Employment of Ph.D. Astronomers

    Science.gov (United States)

    Metcalfe, Travis S.

    2007-05-01

    As in many sciences, the production rate of new Ph.D. astronomers is decoupled from the global demand for trained scientists. As noted by Thronson (1991, PASP, 103, 90), overproduction appears to be built into the system, making the mathematical formulation of surplus astronomer production similar to that for industrial pollution models -- an unintended side effect of the process. Following Harris (1994, ASP Conf., 57, 12), I document the production of Ph.D. astronomers from 1990 to 2005 using the online Dissertation Abstracts database. To monitor the changing patterns of employment, I examine the number of postdoctoral, tenure-track, and other jobs advertised in the AAS Job Register during this same period. Although the current situation is clearly unsustainable, it was much worse a decade ago with nearly 7 new Ph.D. astronomers in 1995 for every new tenure-track job. While the number of new permanent positions steadily increased throughout the late 1990's, the number of new Ph.D. recipients gradually declined. After the turn of the century, the production of new astronomers leveled off, but new postdoctoral positions grew dramatically. There has also been recent growth in the number of non-tenure-track lecturer, research, and support positions. This is just one example of a larger cultural shift to temporary employment that is happening throughout society -- it is not unique to astronomy.

  15. First International Student Obtains His PhD at CAS

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Mr. Ghulam Rasul, the first international student formally enrolled by the Graduate University of CAS (GUCAS) has received his PhD degree this summer after having passed his dissertation defense on May 21 at the CAS Institute of Atmospheric Physics (IAP).

  16. Theo Thole as a PhD ''student''

    NARCIS (Netherlands)

    vanDuijnen, PT

    1997-01-01

    Thee Thole's Ph.D. work was the basis for the Direct Reaction Field method for incorporating a semi-classical ''solvent'' in quantum chemical calculations. The early stages of his work and later progress is reviewed and a typical example of his analytical and programming skills, so far unpublished,

  17. Peer Mentorship and Transformational Learning: PhD Student Experiences

    Science.gov (United States)

    Preston, Jane P.; Ogenchuk, Marcella J.; Nsiah, Joseph K.

    2014-01-01

    The purpose of the paper is to describe our peer mentorship experiences and explain how these experiences fostered transformational learning during our PhD graduate program in educational administration. As a literature backdrop, we discuss characteristics of traditional forms of mentorship and depict how our experiences of peer mentorship was…

  18. The 8th Workshop for PhD Students in Object-Oriented Systems

    DEFF Research Database (Denmark)

    Each year since 1991 there has been a workshop for PhD students at the ECOOP conference. It is every every year conducted by the network of PhD Students in Object-Oriented Systems (PhDOOS), hence it is an event for PhD students by PhD students. The purpose of the PhDOOS network is to help leverag...

  19. 21 CFR 184.1120 - Brown algae.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Brown algae. 184.1120 Section 184.1120 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... Substances Affirmed as GRAS § 184.1120 Brown algae. (a) Brown algae are seaweeds of the species...

  20. Undertaking Individual Transdisciplinary PhD Research for Sustainable Development: Case Studies from South Africa

    Science.gov (United States)

    van Breda, John; Musango, Josephine; Brent, Alan

    2016-01-01

    Purpose: This paper aims to improve the understanding of individual transdisciplinary PhD research in a developing country context, focusing on three individual PhD case studies in South Africa. Design/Methodology/Approach: Multiple-case method was used, and three completed transdisciplinary PhD research efforts undertaken at the Stellenbosch…

  1. Detection of the bovine viral diarrhoea/mucosal disease (BVD/MD) virus in tissues from aborted ruminant foetuses using immunohistochemistry.

    Science.gov (United States)

    Njiro, S M; Nkosi, C M

    2009-12-01

    Various tissues from aborted ruminant foetuses were collected, fixed in formalin and embedded in paraffin wax. Sections were made and exposed to a primary monoclonal antibody against the bovine viral diarrhoea/mucosal disease (BVD/MD) virus, and subsequently to a goat anti-mouse secondary antibody conjugated to horse radish peroxidase (HRP). Diaminobenzidine (DAB) was the substrate and it released a brown pigment in the tissues on reacting with the HRP in an immunohistochemistry (IHC) procedure. Of 27 aborted foetuses, an immunoperoxidase staining reaction was observed in 1 ovine and 5 bovine foetuses. The IHC procedure located BVD/MD viral antigen in a wide variety of foetal tissues including cerebral cortical neurons, the pseudostratified columnar epithelial cells lining the bronchi, alveolar lining cells and alveolar macrophages, hepatocytes, renal tubular lining cells and the Purkinje fibres in the myocardium. PMID:20458863

  2. Cummins MD & HD Accessory Hybridization CRADA -Annual Report FY15

    Energy Technology Data Exchange (ETDEWEB)

    Deter, Dean D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-10-01

    There are many areas of MD and HD vehicles that can be improved by new technologies and optimized control strategies. Component optimization and idle reduction need to be addressed, this is best done by a two part approach that includes selecting the best component technology, and/or architecture, and optimized controls that are vehicle focused. While this is a common focus in the light duty industry it has been gaining momentum in the MD and HD market as the market gets more competitive and the regulations become more stringent. When looking into systems optimization and idle reduction technologies, affected vehicle systems must first be considered, and if possible included in the new architecture to get the most benefit out of these new capabilities. Typically, when looking into idle reduction or component optimization for MD/HD, the vehicle s accessories become a prime candidate for electrification or hybridization. While this has already been studied on light duty vehicles (especially on hybrids and electric vehicles) it has not made any head way or market penetration in most MD and HD applications. If hybrids and electric MD and HD vehicles begin to break into the market this would be a necessary step into the ability to make those vehicles successful by allowing for independent, optimized operation separate from the engine.

  3. Detection of haplotype mutations of the MD-2 gene promoter associated with Der p2-induced allergy using a nanostructured biosensor

    Directory of Open Access Journals (Sweden)

    Chin YT

    2014-03-01

    Full Text Available Yu-Ting Chin,1 En-Chih Liao,2 Chia-Che Wu,1 Gou-Jen Wang,1,3,4 Jaw-Ji Tsai2 1Department of Mechanical Engineering, National Chung-Hsing University, 2Department of Medical Education and Research, Taichung Veterans General Hospital, 3Graduate Institute of Biomedical Engineering, 4PhD Program in Tissue Engineering and Regenerative Medicine, National Chung-Hsing University, Taichung, Taiwan Abstract: Group 2 allergens (Der p2 have been reported to be a major cause of the human immune response to dust mite allergens. In this study, we have demonstrated for the first time the effective differentiation between haplotype mutation and normal genes in the MD-2 gene promoter using a nanostructured biosensor. A 70-mer gene fragment containing the haplotype of two single nucleotide polymorphisms in the MD-2 gene promoter region was used as a probe to detect haplotype mutations associated with Der p2-induced allergy. Discrimination was achieved using electrochemical impedance spectroscopy. The discrimination experiments employed 30 haplotype mutation samples and 30 normal target samples. The haplotype mutation samples and normal target samples could be clearly discriminated, even using samples produced by a five-cycle polymerase chain reaction process. The time and cost of sample preparation for the polymerase chain reaction process in the clinical setting can thus be reduced. Keywords: haplotype mutation detection, nanostructured biosensor, MD-2 gene promoter, electrochemical impedance spectroscopy

  4. 基于C#的MD5加密算法的应用%Application of the MD5 algorithm based on C#

    Institute of Scientific and Technical Information of China (English)

    林宗朝

    2011-01-01

    介绍了WEB SYSTEM中的密钥安全性能。主要讨论了WEB SYSTEM中MD5加密算法,包含客户password安全性分析、MD5加密算法概述、基于C#的MD5加密应用介绍,以及IT SYSTEM中MD5算法的应用与IMPROVEMENT等问题。%The key safety properties of the WEB system is described,and the.MD5 encryption algorithm is discussed mainly including the user password security analysis,MD5 encryption algorithm summary,MD5 encryption applications based on the C# and the improvement of MD5 algorithm.

  5. Novel nuances of human brown fat

    DEFF Research Database (Denmark)

    Scheele, Camilla; Larsen, Therese Juhlin; Nielsen, Søren

    2014-01-01

    There is a current debate in the literature on whether human fat derived from the supraclavicular region should be classified as brown, or as the white fat-derived less potent, brite/beige. This commentary addresses whether the existing classification defined in mice is sufficient to describe the...... types of thermogenic adipocytes in humans. We recently published a contradictory mRNA expression signature of human supraclavicular fat defined by an upregulation of the brite marker TBX1 along with the classical brown markers ZIC1 and LHX8, as well as genes indicating brown fat activity including UCP1......, there was no difference in UCP1, PGC-1α, PRDM16, suggesting both depots had equal brown fat potency. Taken together, supraclavicular brown fat derived from adult humans seems to represent a type of brown fat with distinct features from both subcutaneous white/brite and interscapular brown fat. Therefore...

  6. BI MD Studies on June 29th 2011

    CERN Document Server

    Belohrad, D; Bravin, E; Calvo, E; Dehning, B; Emery, J; Favier, M; Gras, JJ; Guerrero, A; Jeff, A; Lefevre, T; Rabiller, A; Roncarolo, F; Sapinski, M; Soby, L; Steinhagen, R

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 29-June-2011 (from 10 p.m. to 07 a.m.), dedicated to study Beam Current Monitors (BCT), Wire Scaners (WS), Synchrotron Radiation (BSRT), Beam Position (BPM), Wall Current (WCM) and Beam Gas Ionization (BGI) monitors. The MD aimed at performing different studies on the individual monitors. At the same time, it was possible to perform calibration studies with the Abort Gap (AGM) and Longitudinal Density (LDM) monitors that share the extracted light with the BSRT. Additionally some observations about the beam stability and emittance dependence on the chromaticity were performed.

  7. Soybean GmPHD-type transcription regulators improve stress tolerance in transgenic Arabidopsis plants.

    Directory of Open Access Journals (Sweden)

    Wei Wei

    Full Text Available BACKGROUND: Soybean [Glycine max (L. Merr.] is one of the most important crops for oil and protein resource. Improvement of stress tolerance will be beneficial for soybean seed production. PRINCIPAL FINDINGS: Six GmPHD genes encoding Alfin1-type PHD finger protein were identified and their expressions differentially responded to drought, salt, cold and ABA treatments. The six GmPHDs were nuclear proteins and showed ability to bind the cis-element "GTGGAG". The N-terminal domain of GmPHD played a major role in DNA binding. Using a protoplast assay system, we find that GmPHD1 to GmPHD5 had transcriptional suppression activity whereas GmPHD6 did not have. In yeast assay, the GmPHD6 can form homodimer and heterodimer with the other GmPHDs except GmPHD2. The N-terminal plus the variable regions but not the PHD-finger is required for the dimerization. Transgenic Arabidopsis plants overexpressing the GmPHD2 showed salt tolerance when compared with the wild type plants. This tolerance was likely achieved by diminishing the oxidative stress through regulation of downstream genes. SIGNIFICANCE: These results provide important clues for soybean stress tolerance through manipulation of PHD-type transcription regulator.

  8. Analysis of the message digest algorithm MD5%报文摘要算法MD5分析

    Institute of Scientific and Technical Information of China (English)

    燕辉; 叶震; 董泽浩; 高柯俊

    2002-01-01

    随着计算机网络的发展,社会对网络安全的要求也越来越紧迫。文章回顾了网络安全的目标、几种网络攻击方法和网络安全技术,重点分析了普遍用在数据签名中的MD5报文摘要算法。首先描述了MD5报文摘要算法,并对其进行了详细分析,找出了它的缺陷,最后推荐了一种为克服此缺陷而对MD5算法进行的改进方法。

  9. Hardware Implementation of HMAC-MD5 Algorithm%HMAC-MD5算法的硬件实现

    Institute of Scientific and Technical Information of China (English)

    吴旭凡; 胡晨; 田渊; 丁黄胜

    2003-01-01

    信息安全体系中的消息验证是一个非常重要的方面.采用以散列函数为基础的消息验证编码是其中的一种重要方法.现提出了硬件实现一种以MD5算法为基础的消息验证编码(HMAC-MD5)的电路结构.该电路结构通过对MD5核心运算模块的复用,缩小了电路规模,达到了较高的处理速度.用VerilogHDL描述电路结构,并且在FPGA上验证了该结构的正确性.

  10. Club of Bologna International Best PhD Prize 2012

    Directory of Open Access Journals (Sweden)

    Marco Fiala

    2012-06-01

    Full Text Available The Club of Bologna, in collaboration with UNACOMA, will be awarding a prize for the best PhD theses on subjects related to agricultural machinery design and development. Up to ten theses will be selected and the best five of these will have the chance of being presented during the annual Club of Bologna meeting that will be held from 9 to 10 November 2012, on occasion of the EIMA. The authors of the best three PhD theses will also receive a cash prize. The winners will be guests in Bologna of UNACOMA who will cover travelling expenses and hotel accommodation for 2 nights. They will also meet farm machinery manufacturers attending the international trade fair. The winners of the Club of Bologna Prize 2012 will be announced here. Application forms and further information can be downloaded from the Club of Bologna website (http://www.clubofbologna.org/.

  11. Photometric brown-dwarf classification

    CERN Document Server

    Skrzypek, N

    2013-01-01

    We have developed a method "photo-type" to identify and accurately classify L and T dwarfs, onto the standard system, from photometry alone. We combine SDSS, UKIDSS and WISE data and classify point sources by comparing the izYJHKW1W2 colours against template colours for quasars, stars, and brown dwarfs. In a sample of $6.5\\times10^6$ bright point sources, J$<$17.5, from 3150 deg$^2$, we identify and type 898 L and T dwarfs, making this the largest homogeneously selected sample of brown dwarfs to date. The sample includes 713 (125) new (previously known) L dwarfs and 21 (39) T dwarfs. For the previously-known sources, the scatter in the plot of photo-type vs spectral type indicates that our photo-types are accurate to 1.5 (1.0) sub-types rms for L (T) dwarfs. Peculiar objects and candidate unresolved binaries are identified.

  12. Research and Improvement of MD5 Algorithm%MD5算法的研究与改进

    Institute of Scientific and Technical Information of China (English)

    毛熠; 陈娜

    2012-01-01

    MD5 algorithm has important applications in the field of data encryption such as digital signature, identity authentication and so on, but it can not resist differential attack and dictionary attack. This paper does certain special transform on some related variables during message preprocessing course of MD5 to improve probability of data high overflow, and increase the avalanche effect and difficulty of differential cryptanalysis, so that collision problem of MD5 algorithm is solved. Through doing collision detection, coincidence detection of encrypted values before and after improvement for improved algorithm, the improved MD5 is proved safe and practical.%MD5算法在数字签名、身份认证等数据加密领域有重要的应用,但其无法抵御差分攻击和查字典攻击.为此,通过对算法消息处理过程中涉及的一些变量进行特殊变换,提高运算中数据高位溢出的几率,增强其雪崩效应,增加差分分析的难度,由此解决MD5算法的碰撞问题.对改进的算法进行碰撞检测、加密值重合检测以及改进前后加密值的重合检测,结果证明其具有较高的安全性和实用价值.

  13. Lynn Sorbara, PhD | Division of Cancer Prevention

    Science.gov (United States)

    Dr. Lynn Sorbara earned her PhD from Albert Einstein College of Medicine in 1986. Her thesis research was in the areas of the mechanism of action of the drug, Taxol, and of multidrug resistance. After postdoctoral fellowships at the Rockefeller University and the Mount Sinai College of Medicine in Manhattan, she came to the NIH as a Senior Staff Fellow in the Diabetes Branch of NIDDK. |

  14. Iterative Mixture Component Pruning Algorithm for Gaussian Mixture PHD Filter

    OpenAIRE

    Xiaoxi Yan

    2014-01-01

    As far as the increasing number of mixture components in the Gaussian mixture PHD filter is concerned, an iterative mixture component pruning algorithm is proposed. The pruning algorithm is based on maximizing the posterior probability density of the mixture weights. The entropy distribution of the mixture weights is adopted as the prior distribution of mixture component parameters. The iterative update formulations of the mixture weights are derived by Lagrange multiplier and Lambert W funct...

  15. Extended Target Tracking Using a Gaussian-Mixture PHD Filter

    OpenAIRE

    Granström, Karl; Lundquist, Christian; Orguner, Umut

    2012-01-01

    This paper presents a Gaussian-mixture implementation of the phd filter for tracking extended targets. The exact filter requires processing of all possible measurement set partitions, which is generally infeasible to implement. A method is proposed for limiting the number of considered partitions and possible alternatives are discussed. The implementation is used on simulated data and in experiments with real laser data, and the advantage of the filter is illustrated. Suitable remedies are gi...

  16. Research of MD5 shadow table method based on MD5 algorithm%一种融入MD5的影子表算法研究

    Institute of Scientific and Technical Information of China (English)

    袁满; 康峰峰; 黄刚

    2013-01-01

    As for the rapid extraction of source data, the rapid identification of changing data and the rapid incremental extraction of data, underlying the analysis of the working principle of the traditional shadow table, this paper proposed a kind of improved linear algorithm which merged MD5 algorithm into the ST. It scanned compared tables for the linear and eliminates unnecessary inverse operation. During scanning these tables, it employed MD5 algorithm to calculate the whole record ' fingerprint ' , it reduced the frequency and duration of string matching, and it could quickly recognize the changed records. The algorithm was verified practically, and the result shows that the proposed algorithm can improve the efficiency of data extraction in database. Incremental extraction method based on shadow table is a general incremental capturing method, and it can be implemented in any database. These applications can easily be transplanted in all kinds of platforms, so it is suitable to solve the heterogeneous database replication issues.%为了快速提取源头数据、快速识别变化记录以及实现数据的快速增量提取,在剖析传统影子表法的工作原理上,提出基于MD5算法的影子表法的改进型线性算法,对对比表进行线性扫描,排除了不必要的回扫操作;同时通过MD5算法计算整条记录的“指纹”,降低了字符串比对次数和时间,能够迅速识别出发生变化的记录.对所提出算法进行了应用测试,结果表明通过融入MD5算法后的影子表法提高了数据提取效率.基于影子表的增量提取方法是一种通用的增量捕获方法,能在任何数据库上实现;应用程序可以方便地在多种平台间移植,因此很适合解决异构数据库复制问题.

  17. Microlensing, Brown Dwarfs and GAIA

    CERN Document Server

    Evans, N W

    2014-01-01

    The GAIA satellite can precisely measure the masses of nearby brown dwarfs and lower main sequence stars by the microlensing effect. The scientific yield is maximised if the microlensing event is also followed with ground-based telescopes to provide densely sampled photometry. There are two possible strategies. First, ongoing events can be triggered by photometric or astrometric alerts by GAIA. Second, events can be predicted using known high proper motion stars as lenses. This is much easier, as the location and time of an event can be forecast. Using the GAIA source density, we estimate that the sample size of high proper motion ($>300$ mas yr$^{-1}$) brown dwarfs needed to provide predictable events during the 5 year mission lifetime is surprisingly small, only of the order of a hundred. This is comparable to the number of high proper motion brown dwarfs already known from the work of the UKIDSS Large Area Survey and the all-sky WISE satellite. Provided the relative parallax of the lens and the angular Ein...

  18. The multisensor PHD filter: II. Erroneous solution via Poisson magic

    Science.gov (United States)

    Mahler, Ronald

    2009-05-01

    The theoretical foundation for the probability hypothesis density (PHD) filter is the FISST multitarget differential and integral calculus. The "core" PHD filter presumes a single sensor. Theoretically rigorous formulas for the multisensor PHD filter can be derived using the FISST calculus, but are computationally intractable. A less theoretically desirable solution-the iterated-corrector approximation-must be used instead. Recently, it has been argued that an "elementary" methodology, the "Poisson-intensity approach," renders FISST obsolete. It has further been claimed that the iterated-corrector approximation is suspect, and in its place an allegedly superior "general multisensor intensity filter" has been proposed. In this and a companion paper I demonstrate that it is these claims which are erroneous. The companion paper introduces formulas for the actual "general multisensor intensity filter." In this paper I demonstrate that (1) the "general multisensor intensity filter" fails in important special cases; (2) it will perform badly in even the easiest multitarget tracking problems; and (3) these rather serious missteps suggest that the "Poisson-intensity approach" is inherently faulty.

  19. 78 FR 3496 - Maryland Disaster Number MD-00025

    Science.gov (United States)

    2013-01-16

    ... ADMINISTRATION Maryland Disaster Number MD-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3... completed loan applications to: U.S. Small Business Administration, Processing and Disbursement Center... Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite 6050, Washington,...

  20. 77 FR 74908 - Maryland Disaster Number MD-00025

    Science.gov (United States)

    2012-12-18

    ... ADMINISTRATION Maryland Disaster Number MD-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1... completed loan applications to: U.S. Small Business Administration, Processing and Disbursement Center... Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite 6050, Washington,...

  1. Improved Collision Attack on Hash Function MD5

    Institute of Scientific and Technical Information of China (English)

    Jie Liang; Xue-Jia Lai

    2007-01-01

    In this paper, we present a fast attack algorithm to find two-block collision of hash function MD5.The algorithm is based on the two-block collision differential path of MD5 that was presented by Wang et al.In the Conference EUROCRYPT 2005.We found that the derived conditions for the desired collision differential path were not sufficient to guarantee the path to hold and that some conditions could be modified to enlarge the collision set.By using technique of small range searching and omitting the computing steps to check the characteristics in the attack algorithm, we can speed up the attack of MD5 efficiently.Compared with the Advanced Message Modification technique presented by Wang et al.,the small range searching technique can correct 4 more conditions for the first iteration differential and 3 more conditions for the second iteration differential, thus improving the probability and the complexity to find collisions.The whole attack on the MD5 can be accomplished within 5 hours using a PC with Pentium4 1.70GHz CPU.

  2. MD on Injection Quality – Longitudinal and Transverse Parameters

    CERN Document Server

    Drosdal, L; Bohl, T; Bracco, C; Cornelis, K; Damerau, H; Goddard, B; Kain, V; Meddahi, M

    2011-01-01

    Losses at injection depend on the beam quality in the longitudinal and transverse plane in the injectors. During the MD on the 30th of June to 1st of July, 2011, many parameters in the injectors were de-tuned on purpose to see the effect on injection losses and hence bring some understanding to recurring problems with injection quality during LHC filling. The effect of the 800 MHz in the SPS, radial steering, larger momentum spread at the SPS extraction and many other longitudinal parameters were studied during the MD. The MD showed however that the injection losses are dominated by far by the transverse size of the particle population. If the SPS scrapers are correctly positioned, injection losses are low even at the presence of quality issues in the longitudinal plane. To be able to inject brighter 50 ns beams or eventually 25 ns beams, injection losses with nominal emittances (3.5 m) must still be acceptable. This MD showed that nominal emittances can be injected with similar loss levels as the typical ...

  3. 76 FR 36447 - Safety Zone; Patuxent River, Patuxent River, MD

    Science.gov (United States)

    2011-06-22

    ..., 2008, issue of the Federal Register (73 FR 3316). Public meeting We do not now plan to hold a public... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY... a temporary safety zone during the ``NAS Patuxent River Air Expo '11'', which consists of...

  4. The Added Value of a PhD in Medicine--PhD Students' Perceptions of Acquired Competences

    Science.gov (United States)

    Anttila, Henrika; Lindblom-Ylänne, Sari; Lonka, Kristi; Pyhältö, Kirsi

    2015-01-01

    PhD in the field of medicine is more common than in any other domain. Many medical doctors are driven towards PhD, but also students with other backgrounds (usually MSc) are conducting a PhD in medical schools. Higher education has invested a lot in developing generic and research competences. Still little is known about how PhD students…

  5. Developing improved MD codes for understanding processive cellulases

    International Nuclear Information System (INIS)

    The mechanism of action of cellulose-degrading enzymes is illuminated through a multidisciplinary collaboration that uses molecular dynamics (MD) simulations and expands the capabilities of MD codes to allow simulations of enzymes and substrates on petascale computational facilities. There is a class of glycoside hydrolase enzymes called cellulases that are thought to decrystallize and processively depolymerize cellulose using biochemical processes that are largely not understood. Understanding the mechanisms involved and improving the efficiency of this hydrolysis process through computational models and protein engineering presents a compelling grand challenge. A detailed understanding of cellulose structure, dynamics and enzyme function at the molecular level is required to direct protein engineers to the right modifications or to understand if natural thermodynamic or kinetic limits are in play. Much can be learned about processivity by conducting carefully designed molecular dynamics (MD) simulations of the binding and catalytic domains of cellulases with various substrate configurations, solvation models and thermodynamic protocols. Most of these numerical experiments, however, will require significant modification of existing code and algorithms in order to efficiently use current (terascale) and future (petascale) hardware to the degree of parallelism necessary to simulate a system of the size proposed here. This work will develop MD codes that can efficiently use terascale and petascale systems, not just for simple classical MD simulations, but also for more advanced methods, including umbrella sampling with complex restraints and reaction coordinates, transition path sampling, steered molecular dynamics, and quantum mechanical/molecular mechanical simulations of systems the size of cellulose degrading enzymes acting on cellulose

  6. Developmentally regulated expression of two MADS-box genes, MdMADS3 and MdMADS4, in the morphogenesis of flower buds and fruits in apple.

    Science.gov (United States)

    Sung, S K; Yu, G H; Nam, J; Jeong, D H; An, G

    2000-03-01

    Two MADS-box genes, MdMADS3 and MdMADS4, were isolated from the apple (Malus x domestica Borkh.) cultivar Fuji, and their spatial and temporal expression patterns were studied during morphological differentiation of the flower buds and the fruits. Both MdMADS3 and MdMADS4 showed high sequence similarities to FBP2 from petunia, TM5 from tomato, and AGL2, AGL4 from Arabidopsis. Although MdMADS3 was expressed in the inner three whorls of the floral primordium, its expression was hardly detectable in developing fruit. The second gene, MdMADS4, was ubiquitously expressed in the inflorescence meristem, floral meristem, all four floral organs, and fruit. Moreover, MdMADS4 expression was high in the vascular bundles assigned to the floral tube and the carpellary vascular bundles in fruit at early developmental stages. The MdMADS4 transcript also accumulated in embryos of the developing seeds. These results suggest that MdMADS3 and MdMADS4 are involved in different functions, and that MdMADS4 may function in the important events controlling flower and fruit development. PMID:10787044

  7. 基于MD5的迭代散列算法%Iterative Hashing Algorithm Based on MD5

    Institute of Scientific and Technical Information of China (English)

    张青

    2011-01-01

    The paper analyzes the user name and password storage methods and their risks on the internet. On this basis, it analyzes MD5 message digest encryption weaknesses and deciphering means. In response to these decoding methods, it proposes an iterative algorithm based on MD5. This algorithm is immune to the second birthday attack, meanwhile improve the complicates of the the first birthday attack. It is also useful for rainbow table attack. The algorithm can enhance password security features, thereby enhancing the network information transmission and storage security.%分析网络中用户名、密码的存储方式及其存在的风险.在此基础上分析MD5散列算法的弱点及其破译手段.针对这些破泽方法提出基于MD5的迭代散列算法.该算法可以避免第二类生日攻击,并有效提高第一类生日攻击的复杂度,对于破解效率最高的彩虹表也具有免疫性,能够加强密码的安全性能,从而提高网络中信息传递和存储的安全性.

  8. Applied PhD Research in a Work-Based Environment: An Activity Theory-Based Analysis

    Science.gov (United States)

    Granata, S. N.; Dochy, F.

    2016-01-01

    Activity theory is used to compare PhD undertaken at university, that is, academic PhD, with PhD performed in collaboration with industry, that is, semi-industrial PhD. The research is divided into a literature review and a case study. Semi-industrial and academic PhD are modelled as activity systems, and differences are highlighted in terms of…

  9. Surprising Legacies of Brown v. Board

    OpenAIRE

    Minow, Martha Louise

    2014-01-01

    Perhaps the most powerful legacy of Brown v. Board is this: opponents in varied political battles fifty years later each claim ties to the decision and its meaning. So although the analogy between Brown and same-sex marriage has divided Black clergy, each side vies to inherit the civil rights heritage. President George W. Bush invoked Brown in opposing race-conscious college admission practices. The success of Brown in reshaping the moral landscape has been so profound that I fear we do not f...

  10. BROWN TUMOR OF THE FACIAL BONES

    Directory of Open Access Journals (Sweden)

    Violeta Trandafir

    2010-11-01

    Full Text Available Brown tumor arises as a direct result of the effect of parathyroid hormone on bone tissue in some patients with hyperparathyroidism. The lesion localizes in areas of intense bone resorbtion, and the bone defect becomes filled with fibroblastic tissue that can deform the bone and simulate a neoplastic process. Brown tumors can affect the mandible, maxilla, clavicle, ribs and pelvic bones. Most patients with hyperparathyroidism are asymptomatic. Skeletal changes may represent the first manifestations of the disease. Radiologically, brown tumor in the jaws presents as a well-defined radiolucent osteolytic lesion, making it hard to differentiate it from other maxillary expansive lesions that can present with a similar imaging. Brown tumors exhibit no pathognomonic histologic changes. Differentiating between a brown tumor and other giant-cell tumors may be very difficult, even with histology. A final diagnosis can be defined only by evaluating the radiological findings with histopathological, laboratory and clinical data. At present, brown tumor is considered as a reparative cellular process rather than a real neoplasia. This phenomenon is considered as pathognomonic of hyperparathyroidism secondary to renal failure, especially in patients on long-term hemodialysis. The initial treatment of brown tumor involves control of hyperparathyroidism, regardless of whether it is primary or secondary. The clinical management of brown tumor aims primarily to reduce the elevated parathyroid hormone levels by pharmacological treatment. Surgical treatment is reserved to nonresponders or to patients with painful symptomatology or alteration of normal function. Brown tumor can recur if hyperparathyroidism persists or recurs.

  11. The Engrailed-1 Gene Stimulates Brown Adipogenesis

    Directory of Open Access Journals (Sweden)

    Chuanhai Zhang

    2016-01-01

    Full Text Available As a thermogenic organ, brown adipose tissue (BAT has received a great attention in treating obesity and related diseases. It has been reported that brown adipocyte was derived from engrailed-1 (EN1 positive central dermomyotome. However, functions of EN1 in brown adipogenesis are largely unknown. Here we demonstrated that EN1 overexpression increased while EN1 knockdown decreased lipid accumulation and the expressions of key adipogenic genes including PPARγ2 and C/EBPα and mitochondrial OXPHOS as well as BAT specific marker UCP1. Taken together, our findings clearly indicate that EN1 is a positive regulator of brown adipogenesis.

  12. Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders

    Directory of Open Access Journals (Sweden)

    So Hun Kim

    2016-02-01

    Full Text Available Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown adipocyte differentiation, the field of the study of brown fat has gained great interest and is rapidly growing. Brown fat expansion and/or activation results in increased energy expenditure and a negative energy balance in mice and limits weight gain. Brown fat is also able to utilize blood glucose and lipid and results in improved glucose metabolism and blood lipid independent of weight loss. Prolonged cold exposure and beta adrenergic agonists can induce browning of white adipose tissue. The inducible brown adipocyte, beige adipocyte evolving by thermogenic activation of white adipose tissue have different origin and molecular signature from classical brown adipocytes but share the characteristics of high mitochondria content, UCP1 expression and thermogenic capacity when activated. Increasing browning may also be an efficient way to increase whole brown fat activity. Recent human studies have shown possibilities that findings in mice can be reproduced in human, making brown fat a good candidate organ to treat obesity and its related disorders.

  13. Review of "Animal Models in the Light of Evolution" by Niall Shanks, Ph.D., and C. Ray Greek, M.D

    Directory of Open Access Journals (Sweden)

    Wolpert Lewis

    2010-08-01

    Full Text Available Abstract Animal Models in the Light of Evolution provides persuasive evidence that animal models should be used with great caution when applying the results to human diseases. Mice and other model animals are both similar and different, in their biology, to humans.

  14. Human radiation studies: Remembering the early years: Oral history of radiologist Hymer L. Friedell, M.D., Ph.D., conducted January 28, 1995

    International Nuclear Information System (INIS)

    NThis report is a transcript of an interview with Hymer L. Friedell by representatives of the US DOE Office of Human Radiation Experiments. Dr. Friedell was selected for this interview because of his participation in the early stages of the medical use of radioisotopes, his important role in the Manhattan Engineer District Medical Division, and his distinguished medical career and his involvement in the distribution of isotopes and the approval for their use in humans. After a brief biographical sketch Dr. Friedell discusses his remembrances on a wide range of subjects. Topics discussed include pre-war radiation therapy, information provided to patients, the Army Medical Corps and the Manhattan Project, his work at the Chicago Metallurgical Laboratory, inspection visits of Manhattan Project facilities and proposed sites, Plutonium injection studies, and actions of the AEC Isotope Distribution Committee

  15. [The tribute of the pioneer of hypnotherapy--Franz Anton Mesmer, MD, PhD in the history of psychotherapy and medicine].

    Science.gov (United States)

    Radovancević, Ljubomir

    2009-01-01

    Modern hypnosis started with the Austrian physician Franz Anton Mesmer (1734-1815), who believed that the phenomenon known as mesmerism, or animal magnetism, or fluidum was related to an invisible substance--a fluid that runs within the subject or between the subject and the therapist, that is, the hypnotist, or the "magnetizer". The term hypnosis was introduced in the 1840s by a Scottish surgeon James Braid (1795-1860), who believed the subject to be in a particular state of sleep--a trance. In the late 19th century, a French neurologist Jean Martin Charcot (1825-1893) thought hypnotism to be a special physiological state, and his contemporary Hyppotite-Marie Bernheim (1840-1919) believed it to be a psychological state of heightened suggestibility. Sigmund Freud, who studied with Charcot, used hypnosis early in his career to help patients recover repressed memories. He noted that patients would relive traumatic events while under hypnosis, a process know as abreaction. Freud later replaced hypnosis with the technique of free associations. Today, hypnosis is used as a form of therapy (hypnotherapy), a method of investigation to recover lost memories, and research tool. According to Caplan & Sadock, F.A. Mesmer is generally thought of as the fons et origo of modern psychotherapy; and from the early techniques of mesmerism, it is said, have evolved the more elaborate and sophisticated therapeutic measures of the analyst and his colleagues. Although Mesmer was certainly dealing with individuals suffering from a variety of neurotic disorders, and though the clinical successes he achieved were the result of psychological processes that his procedures induced in his patients, Mesmer's theoretical formulations, his understanding of the nature of the treatment he developed, and his specific procedures were all totally different from those of the 20th century analyst. He was one of the corne stones in the development of psychoanalysis through hypnosis mainly of hysterical patients. PMID:20166775

  16. Review of "Animal Models in the Light of Evolution" by Niall Shanks, Ph.D., and C. Ray Greek, M.D

    OpenAIRE

    Wolpert Lewis

    2010-01-01

    Abstract Animal Models in the Light of Evolution provides persuasive evidence that animal models should be used with great caution when applying the results to human diseases. Mice and other model animals are both similar and different, in their biology, to humans.

  17. Human radiation studies: Remembering the early years: Oral history of radiologist Henry I. Kohn, M.D., Ph.D., conducted September 13, 1994

    International Nuclear Information System (INIS)

    This report is a transcript of an interview of Dr. Henry I. Kohn by representatives of the US DOE Office of Human Radiation Experiments. Dr. Kohn was selected for this interview because of the positions he held at Oak Ridge National Laboratory, University of California at San Francisco, and Harvard Medical School. Dr. Kohn discussed his remembrances of his experiences in blood chemistry of animals and patients exposed to radiation, and his remembrances of several radiobiologists

  18. Human radiation studies: Remembering the early years: Oral history of physician James S. Robertson, M.D., Ph.D., conducted January 20, 1995

    International Nuclear Information System (INIS)

    This report is a transcript of in interview of Dr. James S. Robertson by representatives of the DOE Office of Human Radiation Experiments. Dr. Robertson was chosen for this interview because of his research at Brookhaven National Laboratory, especially on Boron Neutron Capture Therapy (BNCT); his work at the United States Naval Defense Laboratory; and his work at the Atomic Energy Commission. After a brief biographical sketch Dr. Robertson discusses research on human subjects at Berkeley, his contributions to the beginnings of Neutron Capture Therapy at Brookhaven, his participation with the Brookhaven Human Use Committee, his involvement in the study of the effects of Castle Bravo event on the Marshallese, and his work with the Naval Radiological Defense Laboratory

  19. Human radiation studies: Remembering the early years. Oral history of Dr. John W. Gofman, M.D., Ph.D., December 20, 1994

    International Nuclear Information System (INIS)

    Dr. John W. Gofman was interviewed by representatives of US DOE Office of Human Radiation Experiments (OHRE) concerning his research at the University of California, Berkeley and his biomedical work at Lawrence Livermore Radiation Laboratory. Following a short biographical sketch, Dr. Gofman relates his remembrances with the discovery and chemistry of uranium-233, the Manhattan project, laboratory production of the first milligram of plutonium, pre-1945 medical use of high-dosage radiation, medical treatments with phosphorus 32, and fallout. Dr. Gofman also discusses his relationships with Professor Oppenheimer, Joe Hamilton, Ernest Lawrence, and other. Then Dr. Gofman describes his pioneering work on his true interests concerning heart disease, heparin, and lipoproteins. Finally intra-AEC political issues are discussed relating to testing of atomic weapons

  20. MD210 Note: Creation of Hollow Bunches in the PSB

    CERN Document Server

    Oeftiger, Adrian; Findlay, Alan James; Hancock, Steven; Rumolo, Giovanni; CERN. Geneva. ATS Department

    2016-01-01

    MD210 aims for the creation of longitudinally hollow bunches in the CERN PS Booster. The first three sessions have been carried out using the radial loop feedback system in order to drive the beam on a dipolar parametric resonance (instead of the phase loop). It has been found that the damping by the phase loop inhibits the excitation of the resonance to a major extent. The hollow distributions generated under these circumstances fail to reach a satisfying bunching factor. Nonetheless, proving the principally successful application of this technique to the PS Booster promises good results once the phase loop system supports trim functions. The approach, actions and detailed results of the first three MD sessions are presented in this paper.

  1. MD 382: Beam Transfer Function and diffusion mechanisms

    CERN Document Server

    Tambasco, Claudia; Buffat, Xavier; Crouch, Matthew; Pieloni, Tatiana; Boccardi, Andrea; Fuchsberger, Kajetan; Gasior, Marek; Kotzian, Gerd; Lefevre, Thibaut; Pojer, Mirko; Salvachua Ferrando, Belen Maria; Solfaroli Camillocci, Matteo; Giachino, Rossano; CERN. Geneva. ATS Department

    2016-01-01

    The Beam Transfer Function (BTF) measurements have been previously tested in the LHC during MD block 1 and 2. Different machine configurations (i.e. energy, beam intensity, emittance etc...) have been tested to determine a safe set-up (excitation amplitude) of the system to be completely transparent to the beam (no emittance blow-up neither losses). The aim of this experiment in MD block 3 was to characterize the Stability Diagram (SD) in the presence of diffusion mechanisms induced by excited resonances due to beam-beam long range and Landau octupole interplay. During the experiment, BTF measurements have been acquired at flat top for different settings of Landau octupole current, different chromaticity values and transverse feedback gains. In this note the description of the experiment is presented together with some preliminary results.

  2. A Fast Attack Algorithm on the MD5 Hash Function

    Institute of Scientific and Technical Information of China (English)

    WANG Zhang-yi; ZHANG Huan-guo; QIN Zhong-ping; MENG Qing-shu

    2006-01-01

    The sufficient conditions for keeping desired differential path of MD5 was discussed. By analyzing the expanding of subtraction difference, differential characters of Boolean functions, and the differential characters of shift rotation, the sufficient conditions for keeping desired differential path could be obtained. From the differential characters of shift rotation, the lacked sufficient conditions were found. Then an algorithm that reduces the number of trials for finding collisions were presented. By restricting search space, search operation can be reduced tc 234 for the first block and 230 for the second block. The whole attack on the MD5 can be accomplished within 2C hours using a PC with 1.6 G CPU.

  3. MS PHD'S Professional Development Program: A Scientific Renaissance in Cyberspace

    Science.gov (United States)

    Powell, J. M.; Williamson, V. A.; Griess, C. A.; Pyrtle, A. J.

    2004-12-01

    This study is a component of a four-year investigation of MS PHD'S Professional Development Program's virtual community through the lenses of underrepresented minority students in Earth system science and engineering fields. In this presentation, the development, assessment and projected utilization of the ongoing study will be discussed. The overall goal of this study is to examine the effectiveness of virtual team building methods and understand how the development of a communal cyberinfrastructure acts as an integral part of the emergence of a Scientific Renaissance. The exemplar, Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S), provides professional development experiences to facilitate the advancement of students of color achieving outstanding Earth system careers. Undergraduate and graduate students are supported through access to scientific conferences, mentorship and virtual community building. Framed by critical theory, this ethnographic exploration uses a mixed methods research design to record, observe, and analyze both the processes and products of the website, listserv and synchronous web-based dialogue. First, key findings of the formative evaluation and annual reports of the successfully implemented 2003 MS PHD'S Pilot Project are presented. These findings inform future evaluations of the use of technological resources and illustrate how this public space provides peer support and enriched research opportunities. Quantitative methods such as statistical analysis, academic and professional tracking and evaluative tools for scientific content and competency are complimented by qualitative methods that include observations, heuristic case studies and focus group interviews. The findings of this ongoing investigation will provide insight on how national organizations, higher education practitioners, community-based support systems and underrepresented minorities in the sciences promote diversity by developing

  4. Towards automatic coupling corrections with DOROS BPMs (MD750)

    CERN Document Server

    Persson, Tobias Hakan Bjorn; Langner, Andy Sven; Lefevre, Thibaut; Maclean, Ewen Hamish; Malina, Lukas; Olexa, Jakub; Skowronski, Piotr Krzysztof; Garcia-Tabares Valdivieso, Ana; Coello De Portugal - Martinez Vazquez, Jaime Maria; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2015-01-01

    BPMs close to IP1 and IP5 have been equipped with the new DOROS (Diode ORbit OScillation) system which provides precise orbit and turn-by-turn data [1]. In this MD-note we report on the rst measurements with the DOROS system to measure the transverse coupling. Furthermore, we compare the results and the performance of the system to the normal BPMs.

  5. MD 349: Impedance Localization with AC-dipole

    CERN Document Server

    Biancacci, Nicolo; Metral, Elias; Salvant, Benoit; Papotti, Giulia; Persson, Tobias Hakan Bjorn; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the distribution of the transverse impedance of the LHC by observing the phase advance variation with intensity between the machine BPMs. Four injected bunches with different intensities are excited with an AC dipole and the turn by turn data is acquired from the BPM system. Through post-processing analysis the phase variation along the machine is depicted and, from this information, first conclusions of the impedance distribution can be drawn.

  6. Analytical applications of MD-FIA-optical detection systems

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A brief introduction of recent research works in our laboratory concerning microdialysis(MD) based on optical detection combined with FIA is made in this mini-review. A biosensor system has been designed and realized the real time in vivo monitoring of some important clinic substances such as calcium, uric acid. The system has also been used to study the in vitro binding of drug-protein.

  7. Application of MD Simulations to Predict Membrane Properties of MOFs

    OpenAIRE

    Elda Adatoz; Seda Keskin

    2015-01-01

    Research Article Application of MD Simulations to Predict Membrane Properties of MOFs Elda Adatoz and Seda Keskin Chemical and Biological Engineering, Koc University, Rumelifeneri Yolu, Sariyer, 34450 Istanbul, Turkey Correspondence should be addressed to Seda Keskin; Received 22 May 2015; Accepted 13 July 2015 Academic Editor: Yanlin Song Copyright © 2015 E. Adatoz and S. Keskin. This is an open access article distributed under the Creative Commons A...

  8. A Secure Hash Function MD-192 With Modified Message Expansion

    OpenAIRE

    Harshvardhan Tiwari; Dr. Krishna Asawa

    2010-01-01

    Cryptographic hash functions play a central role in cryptography. Hash functions were introduced in cryptology to provide message integrity and authentication. MD5, SHA1 and RIPEMD are among the most commonly used message digest algorithm. Recently proposed attacks on well known and widely used hash functions motivate a design of new stronger hash function. In this paper a new approach is presented that produces 192 bit message digest and uses a modified message expansion mechanism which gene...

  9. MD 754: Instability Threshold for Train with 25ns Spacing

    CERN Document Server

    Carver, Lee Robert; Biancacci, Nicolo; Iadarola, Giovanni; Levens, Tom; Metral, Elias; Salvant, Benoit; Wang, Na; CERN. Geneva. ATS Department

    2016-01-01

    Measurements made since the beginning of run II at 6.5 TeV have shown that there is a large discrepancy in the instability thresholds between single bunches and trains of 72 bunches with 25ns spacing, whereas the same result is expect for pure impedance-induced instabilities. One possible explanation is that the presence of electron cloud is affecting the beam stability. This MD will attempt to determine if electron cloud is the dominant mechanism affecting beam stability.

  10. Role of PhD Students in the Development of Environmental Engineering Study Programs

    OpenAIRE

    Dzene, I; Jaunzems, D

    2008-01-01

    Since 2000 in Riga Technical University Institute (RTU) of Energy Systems and Environment (IESE) realize study program “Environment science” in two academic levels – bachelor and master degree, but since 2005 – also in environmental engineering PhD level study program. Two main blocks of possibilities of PhD students are research projects and pedagogical activities. PhD students have a significant role and opportunities in development process of environmental engineering study programs as alm...

  11. Hrvoje Tomić, PhD in Technical Sciences

    Directory of Open Access Journals (Sweden)

    Siniša Mastelić Ivić

    2010-12-01

    Full Text Available Hrvoje Tomić defended his PhD thesis Geospatial Data Analysis for the Purpose of Real Estate Valuation in Urban Areas at the Faculty of Geodesy, University of Zagreb, on November 15, 2010. His mentor was Prof. Dr. Siniša Mastelić Ivić, and the other two members of the Grading and Defence Committee were Assist. Prof. Dr. Vlado Cetl and Prof. Dr. Goran Poljanec from the Faculty of Civil Engineering, University of Zagreb.

  12. Rinaldo Paar, PhD in Technical Sciences

    Directory of Open Access Journals (Sweden)

    Zdravko Kapović

    2011-12-01

    Full Text Available Rinaldo Paar defended his PhD thesis Geospatial Databases of Objects in the Highway Management System of the Republic of Croatia at the Faculty of Geodesy, University of Zagreb on 29 June 2010. His thesis supervisor was Prof. Dr. Zdravko Kapović. The Examining Committee comprised Prof. Dr. Gorana Novaković, Prof. Dr. Zdravko Kapović, Prof. Dr. Marko Džapo (all of the Faculty of Geodesy and Prof. Dr. Zlatko Šavor and Prof. Dr. Ljudevit Herceg of the Faculty of Civil Engineering, University of Zagreb.

  13. Andrija Krtalić, PhD in Technical Sciences

    Directory of Open Access Journals (Sweden)

    Miljenko Lapaine

    2011-12-01

    Full Text Available Andrija Krtalić successfully defended his PhD thesis Decision Support System in Conditions of Uncertainty in Demining Activities Based on Remote Sensing Methods at the Faculty of Geodesy, University of Zagreb on 11 July 2011. The thesis was examined by an Examining Committee composed of Prof. Emer. Nedjeljko Frančula, Prof. Dr. Miljenko Lapaine, Prof. Dr. Renata Pernar (Faculty of Forestry, University of Zagreb, Prof. Dr. Hrvoje Gold (Faculty of Traffic Sciences in Zagreb and Prof. Dr. Milan Bajić (supervisor.

  14. Can maitake MD-fraction aid cancer patients?

    Science.gov (United States)

    Kodama, Noriko; Komuta, Kiyoshi; Nanba, Hiroaki

    2002-06-01

    Maitake mushroom (Grifola frondosa) MD-fraction containing beta-1,6 glucan with beta-1,3 branched chains has previously exhibited strong anticancer activity by increasing immune-competent cell activity.1,2 In this non-random case series, a combination of MD-fraction and whole maitake powder was investigated to determine its effectiveness for 22- to 57-year-old cancer patients in stages II-IV. Cancer regression or significant symptom improvement was observed in 58.3 percent of liver cancer patients, 68.8 percent of breast cancer patients, and 62.5 percent of lung cancer patients. The trial found a less than 10-20 percent improvement for leukemia, stomach cancer, and brain cancer patients. Furthermore, when maitake was taken in addition to chemotherapy, immune-competent cell activities were enhanced 1.2-1.4 times, compared with chemotherapy alone. Animal studies have supported the use of maitake MD-fraction for cancer. PMID:12126464

  15. Review of 40-year MD theses in Medical Oncology

    International Nuclear Information System (INIS)

    Background and objective: It is almost 40 years since the foundation of the Medical Oncology (MO) Department. We aimed to appraise the clinical research to fulfill the Medical Doctorate (MD) degree in MO at the National Cancer Institute, Cairo University (NCI, CU). Methods: This review included 62 MD theses containing 66 studies. They were reviewed regarding aims, type of study, clinical trial phase, design and methodology, statistical tests, results, limitations, consent and IRB approval. Theses were grouped into 3 periods: 1970-1989, 1990-1999 and 2000- 2008. Results: Almost 76% of the studies were interventional and 24% were observational. Informed consent and Institutional Review Board approval were mentioned in 18 and 2 studies, respectively. While all studies mentioned the aims, none, clearly mentioned the research question. Outcomes were mainly efficacy followed by safety. Study design was inadequately considered, especially in 70’s–80’s period (p = 0.038). Median sample size and study duration were almost stable through the three periods (p = 0.441, 0.354, respectively). Most of the studies used both descriptive and analytical statistical methods. In a descending order, researched cancers were lymphoma, breast, leukemia, liver, urinary bladder, lung and colorectal. The commonest stages researched were IV and III. The number of studies focused on assessing biomarkers, biomarkers plus drugs/procedures, drugs and procedures are 20, 20, 16 and 6, respectively. Conclusion: With time, research within MD theses in MO increased quantitatively and qualitatively. Improvements were noticeable in documentation of study design.

  16. Structure and Properties of HELICAL CARBON NANOTUBES through MD Simulations

    Science.gov (United States)

    Dahiya, Akshay; Verma, Deepti; Gupta, Shakti S.

    Helical Carbon Nanotubes (HCNTs) are coiled 3-valent carbon networks which represent pure carbon helix. Here we study the geometries of two classes: hexagonal helix containing purely polyhex networks and the second class with 5-and 7-membered rings besides hexagons. We followed a model of hexagonal, single wall HCNTs, and determined their relaxed configuration using MD simulations based on Tersoff potential. A race-track like structure is observed in the cross-section of HCNTs upon minimization. For generating class two helix, the adjacency matrix eigenvector's (AME) method is applied which utilizes 3-coordinated tiling of the plane by 5-,6-,and 7-membered ring for the construction of helical structures. The application of the AME method to torusenes is crucial for class two helix generation as it is based on an appropriate choice of bi-lobial eigenvectors triplet which can be selected on the basis of their nodal properties as verified here. After 3-D transformations the final structure was obtained with the help of MM3-potential based MD simulations on Tinker commercial code. The spring constants of HCNTs are computed through MD simulations.

  17. Brown dwarf disks with ALMA

    Energy Technology Data Exchange (ETDEWEB)

    Ricci, L.; Isella, A. [Department of Astronomy, California Institute of Technology, MC 249-17, Pasadena, CA 91125 (United States); Testi, L.; De Gregorio-Monsalvo, I. [European Southern Observatory, Karl-Schwarzschild-Strasse 2, D-85748 Garching (Germany); Natta, A. [INAF-Osservatorio Astrofisico di Arcetri, Largo E. Fermi 5, I-50125 Firenze (Italy); Scholz, A., E-mail: lricci@astro.caltech.edu [School of Cosmic Physics, Dublin Institute for Advanced Studies, 31 Fitzwilliam Place, Dublin 2 (Ireland)

    2014-08-10

    We present Atacama Large Millimeter/submillimeter Array continuum and spectral line data at 0.89 mm and 3.2 mm for three disks surrounding young brown dwarfs and very low mass stars in the Taurus star forming region. Dust thermal emission is detected and spatially resolved for all the three disks, while CO(J = 3-2) emission is seen in two disks. We analyze the continuum visibilities and constrain the disks' physical structure in dust. The results of our analysis show that the disks are relatively large; the smallest one has an outer radius of about 70 AU. The inferred disk radii, radial profiles of the dust surface density, and disk to central object mass ratios lie within the ranges found for disks around more massive young stars. We derive from our observations the wavelength dependence of the millimeter dust opacity. In all the three disks, data are consistent with the presence of grains with at least millimeter sizes, as also found for disks around young stars, and confirm that the early stages of the solid growth toward planetesimals occur also around very low-mass objects. We discuss the implications of our findings on models of solids evolution in protoplanetary disks, the main mechanisms proposed for the formation of brown dwarfs and very low-mass stars, as well as the potential of finding rocky and giant planets around very low-mass objects.

  18. Implementation of MD5 Fast Decryption Algorithm Based on Graphic Processing Unit%基于GPU的MD5高速解密算法的实现

    Institute of Scientific and Technical Information of China (English)

    乐德广; 常晋义; 刘祥南; 郭东辉

    2010-01-01

    MD5快速碰撞算法由于不支持逆向过程而无法在MD5密码攻击中得到实际应用.针对上述问题,通过分析基于图形处理单元(GPU)的MD5密码并行攻击算法原理,设计基于GPU的MD5高速解密算法,在此基础上实现一个MD5高速密码攻击系统.测试结果证明,该算法能有效加快MD5密码破解速度.

  19. Isolation of glycoproteins from brown algae.

    OpenAIRE

    Surendraraj, Alagarsamy; Farvin Koduvayur Habeebullah , Sabeena; Jacobsen, Charlotte

    2015-01-01

    The present invention relates to a novel process for the isolation of unique anti-oxidative glycoproteins from the pH precipitated fractions of enzymatic extracts of brown algae. Two brown seaweeds viz, Fucus serratus and Fucus vesiculosus were hydrolysed by using 3 enzymes viz, Alcalase, Viscozyme and Termamyl and the glycoproteins were isolated from these enzyme extracts.

  20. The Indirectness of Young Goodman Brown

    Institute of Scientific and Technical Information of China (English)

    袁臣

    2010-01-01

    Young Goodman Brown is one the best short fictions written by Nathaniel Hawthorne in 1835. The indirectness of the Young Goodman Brown can be seen from the produce, narration and the characteristics of the short fiction. The indirectness of expression or description leaves enough space for readers to understand the theme of the short fiction by themselves.

  1. Microlensing Binaries with Candidate Brown Dwarf Companions

    DEFF Research Database (Denmark)

    Shin, I.-G; Han, C.; Gould, A.;

    2012-01-01

    Brown dwarfs are important objects because they may provide a missing link between stars and planets, two populations that have dramatically different formation histories. In this paper, we present the candidate binaries with brown dwarf companions that are found by analyzing binary microlensing ...

  2. Isolation of glycoproteins from brown algae

    DEFF Research Database (Denmark)

    2015-01-01

    The present invention relates to a novel process for the isolation of unique anti-oxidative glycoproteins from the pH precipitated fractions of enzymatic extracts of brown algae. Two brown seaweeds viz, Fucus serratus and Fucus vesiculosus were hydrolysed by using 3 enzymes viz, Alcalase, Viscozyme...

  3. Application of MD5 Algorithm in Database System%MD5算法在数据库系统中的应用

    Institute of Scientific and Technical Information of China (English)

    罗金涛

    2013-01-01

    数据加密是保护数据安全的重要手段,MD5是目前信息安全领域中使用比较广泛的加密算法,对MD5算法的原理进行了分析,并将MD5算法应用在数据库的登录验证过程中.

  4. The Application Research of MD5 Encryption Algorithm in DCT Digital Watermarking

    Science.gov (United States)

    Xijin, Wang; Linxiu, Fan

    This article did the preliminary study of the application of algorithm for MD5 in the digital watermark. It proposed that copyright information will be encrypted using an algorithm MD5, and made rules for the second value image watermarks, through DCT algorithm that embeds an image by the carrier. The extraction algorithms can pick up the watermark and restore MD5 code.

  5. Application of MD5 Encryption Algorithm Based on C# Technology%基于C#技术的MD5加密算法的应用

    Institute of Scientific and Technical Information of China (English)

    王倩丽

    2010-01-01

    在对Message-Digest Algorithm 5进行简要描述的同时,对MD5算法的原理作深入分析.运用MD5算法,采用目前流行的C#语言进行了具体研究,设计了MD5加密演示系统,经过测试该系统可以准确实现数据的MD5加密.

  6. MD5算法在用户口令认证中的应用%The Application of MD5 Algorithm in The User Password Authentication

    Institute of Scientific and Technical Information of China (English)

    刘洪民; 印帮辉

    2014-01-01

    MD5算法是目前比较安全且易用的加密算法,其在密码领域有着举足轻重的地位.本文通过介绍MD5算法的特点及加密原理,分析了MD5算法在用户口令认证中的安全隐患,给出了用户口令认证应用中如何提高MD5算法安全性的措施和方法.

  7. I-determinants for a successful PhD or postdoctoral outcome.

    Science.gov (United States)

    Sørensen, Henrik Toft

    2016-01-01

    Many resources are invested in research training, but very little literature exists on predictors for a successful PhD and postdoctoral training outcome. A PhD program has two overall objectives: to extend knowledge about a hopefully important health topic and to provide extensive training to improve the PhD student's skills through learning research methods and collaboration. A substantial number of PhD students may run into some kind of problem in the course of their PhD program. In this article, some determinants all starting with an "I" and indicative of a good PhD outcome are reported. The successful PhD student can be described as having an Interest in the PhD program, an Incentive for the program, and an Idea of what he or she wants to investigate, showing Initiative, and having high personal Integrity and good Interpersonal relationships. When these so-called I-determinants are present, the likelihood of success in a PhD program is high. More evidence is available for selection of candidates for postdoctoral appointments since it is known that the postdoctoral candidate has completed a PhD program, published papers in peer-reviewed journals, and received awarded grants. However, other characteristics determine a successful transition of the postdoctoral candidate into a research leader. These determinants are Identity, Independence and Image, Implementation ability in terms of being able to implement decisions and projects, working with Innovative and Important topics, having In-depth knowledge of the research topic, being Interactive and Integrated with the scientific community, and Internationally oriented. In conclusion, regardless of the framework of research, the personal characteristics of a researcher play a very important role in the quality of research. Application of some of the principles mentioned in this article might allow decision to reach a more evidence-based way to recruit PhD students and postdoctorals. PMID:27574466

  8. Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S) Beyond the PhD Professional Development Program: A Pilot Project

    Science.gov (United States)

    Johnson, A.; Jearld, A.; Williamson Whitney, V.; Huggans, M.; Ricciardi, L.; Thomas, S. H.; Jansma, P. E.

    2012-12-01

    In 2011 the Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S)® initiative launched its newest activity entitled the MS PHD'S "Beyond the PhD (B-PhD) Professional Development Program." This exciting new program was designed to facilitate the development of a new community of underrepresented minority (URM) doctoral candidates and recent doctorate degree recipients in Earth system science (ESS)-related fields. The MS PHD'S B-PhD provides customized support and advocacy for MS PHD'S B-PhD participants in order to facilitate smoother and informed transitions from graduate school, to postdoctoral and tenure-track positions, as well as other "first" jobs in government, industry, and non-profit organizations. In November 2011 the first cohort of MS PHD'S B-PhD participants engaged in intensive sessions on the following topics: "Toolkits for Success for Academia, Business/Industry, Federal Government and Non-Profits", "Defining Short, Mid and Long Term Career Goals", "Accessing and Refining Skill Sets and Other Door Openers", "International Preparation and Opportunities", "Paying it Forward/Lifting as You Climb", and "Customized Strategies for Next Steps". This pilot event, which was hosted by the University of Texas at Arlington's (UTA) College of Science, also provided opportunities for participants to serve as guest lecturers in the UTA's Colleges of Science and Engineering and included one-on-one discussions with MS PHD'S B-PhD mentors and guest speakers who are well established within their individual ESS fields. Insights regarding opportunities, challenges and obstacles commonly faced by URMs within the ESS fields, as well as strategies for success were shared by MS PHD'S B-PhD mentors and guest speakers. Survey results indicate that MS PHD'S B-PhD participants appreciated not only the material covered during this pilot activity, but also appreciated the opportunity to become part of a community of young URM ESS

  9. Auroral Phenomena in Brown Dwarf Atmospheres

    Science.gov (United States)

    Pineda, J. Sebastian; Hallinan, Gregg

    2016-01-01

    Since the unexpected discovery of radio emission from brown dwarfs some 15 years ago, investigations into the nature of this emission have revealed that, despite their cool and neutral atmospheres, brown dwarfs harbor strong kG magnetic fields, but unlike the warmer stellar objects, they generate highly circularly polarized auroral radio emission, like the giant planets of the Solar System. Our recent results from Keck LRIS monitoring of the brown dwarf LSR1835+32 definitively confirm this picture by connecting the auroral radio emission to spectroscopic variability at optical wavelengths as coherent manifestations of strong large-scale magnetospheric auroral current systems. I present some of the results of my dissertation work to understand the nature brown dwarf auroral phenomena. My efforts include a survey of Late L dwarfs and T dwarfs, looking for auroral Hα emission and a concurrent survey looking for the auroral emission of H3+ from brown dwarfs with radio pulse detections. I discuss the potential connection of this auroral activity to brown dwarf weather phenomena and how brown dwarf aurorae may differ from the analogous emission of the magnetized giant planets in the Solar System.

  10. Doc of prophage P1 is inhibited by its antitoxin partner Phd through fold complementation

    DEFF Research Database (Denmark)

    Garcia-Pino, Abel; Christensen-Dalsgaard, Mikkel; Wyns, Lode;

    2008-01-01

    Prokaryotic toxin-antitoxin modules are involved in major physiological events set in motion under stress conditions. The toxin Doc (death on curing) from the phd/doc module on phage P1 hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation. This...

  11. Learning from a Lived Experience of a PhD: A Reflexive Ethnography of Two Journeys

    Science.gov (United States)

    Aziato, Lydia

    2015-01-01

    Introduction: Nurses globally have strived to obtain a Doctor of Philosophy Degree (PhD) especially those in academia. Few publications have focused on lived experiences of nurses especially those reporting failed attempts. Thus, this paper presents how lessons learnt from a failed attempt of a PhD in Nursing was used to achieve an outstanding…

  12. The 7th Workshop for PhD Students in Object-Oriented Systems

    DEFF Research Database (Denmark)

    It is a tradition at ECOOP conferences to have a workshop for PhD students, conducted by the network of PhD Students in Object-Oriented Systems (PhDOOS). The purpose of this network is to help leveraging the collective resources of young researchers in the object community by improving the commun...

  13. Delivering an Organizational Leadership PhD Program at a Distance: University of Oklahoma

    Science.gov (United States)

    Rodgers, Joseph Lee; Williams, T. H. Lee

    2011-01-01

    In this chapter, the authors identify and review a number of key features in the successful development and maintenance of a PhD program delivered at a distance. The University of Oklahoma's PhD program in organizational leadership was developed in the early 1990s and delivered (primarily, but not completely) to military personnel and families…

  14. A Secure Hash Function MD-192 With Modified Message Expansion

    CERN Document Server

    Tiwari, Harshvardhan

    2010-01-01

    Cryptographic hash functions play a central role in cryptography. Hash functions were introduced in cryptology to provide message integrity and authentication. MD5, SHA1 and RIPEMD are among the most commonly used message digest algorithm. Recently proposed attacks on well known and widely used hash functions motivate a design of new stronger hash function. In this paper a new approach is presented that produces 192 bit message digest and uses a modified message expansion mechanism which generates more bit difference in each working variable to make the algorithm more secure. This hash function is collision resistant and assures a good compression and preimage resistance.

  15. Brown Dwarfs at the Exoplanet Mass Boundary

    Science.gov (United States)

    Faherty, J. K.; Cruz, K. L.; Rice, E. L.; Riedel, A.

    2014-10-01

    Young brown dwarfs and directly-imaged exoplanets have enticingly similar photometric and spectroscopic characteristics, indicating that their cool, low gravity atmospheres should be studied in concert. Similarities between the peculiar shaped H band, near and mid-IR photometry as well as location on color magnitude diagrams provide important clues about how to extract physical properties of planets from current brown dwarf observations. Our team has assigned >30 brown dwarfs to 10-150 Myr nearby moving groups. In so doing, we have discovered important diversity among this extremely low-mass (10 - 30 M_{Jup}) age-calibrated sample indicating that cloud properties play a critical role in their observables.

  16. Study on Extrusion Technological Parametersof Brown Rice

    Institute of Scientific and Technical Information of China (English)

    ZhuYongyi; ZhouXianqing; LingLizhong

    2001-01-01

    Abstract: Extrusion is an efficient measure to improve the texture and physic-chemical properties of brown rice. The polynomial degree two model of extrusiontechnological parameters and gelatinized degree, water absorption index, water solubleindex and moisture content of extruded matter was obtained by methods of single factorand response surface methodology, R2=0.9649, 0.8745, 0.9079, 0.8677. The optimaltechnoiogica! parameters of brown rice extrusion were figured out as follows:moisturecontent of brown rice, 11.42%, speed of screw, 30rpm, feeding speed, and 20rpm.

  17. Young Brown Dwarfs as Giant Exoplanet Analogs

    CERN Document Server

    Faherty, Jacqueline K; Rice, Emily L; Riedel, Adric

    2013-01-01

    Young brown dwarfs and directly-imaged exoplanets have enticingly similar photometric and spectroscopic characteristics, indicating that their cool, low gravity atmospheres should be studied in concert. Similarities between the peculiar shaped H band, near and mid-IR photometry as well as location on color magnitude diagrams provide important clues about how to extract physical properties of planets from current brown dwarf observations. In this proceeding we discuss systems newly assigned to 10-150 Myr nearby moving groups, highlight the diversity of this uniform age-calibrated brown dwarf sample, and reflect on their implication for understanding current and future planetary data.

  18. Multi-Target Detection from Full-Waveform Airborne Laser Scanner Using Phd Filter

    Science.gov (United States)

    Fuse, T.; Hiramatsu, D.; Nakanishi, W.

    2016-06-01

    We propose a new technique to detect multiple targets from full-waveform airborne laser scanner. We introduce probability hypothesis density (PHD) filter, a type of Bayesian filtering, by which we can estimate the number of targets and their positions simultaneously. PHD filter overcomes some limitations of conventional Gaussian decomposition method; PHD filter doesn't require a priori knowledge on the number of targets, assumption of parametric form of the intensity distribution. In addition, it can take a similarity between successive irradiations into account by modelling relative positions of the same targets spatially. Firstly we explain PHD filter and particle filter implementation to it. Secondly we formulate the multi-target detection problem on PHD filter by modelling components and parameters within it. At last we conducted the experiment on real data of forest and vegetation, and confirmed its ability and accuracy.

  19. The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

    Directory of Open Access Journals (Sweden)

    Inmaculada Segura

    2016-03-01

    Full Text Available Neuronal function is highly sensitive to changes in oxygen levels, but how hypoxia affects dendritic spine formation and synaptogenesis is unknown. Here we report that hypoxia, chemical inhibition of the oxygen-sensing prolyl hydroxylase domain proteins (PHDs, and silencing of Phd2 induce immature filopodium-like dendritic protrusions, promote spine regression, reduce synaptic density, and decrease the frequency of spontaneous action potentials independently of HIF signaling. We identified the actin cross-linker filamin A (FLNA as a target of PHD2 mediating these effects. In normoxia, PHD2 hydroxylates the proline residues P2309 and P2316 in FLNA, leading to von Hippel-Lindau (VHL-mediated ubiquitination and proteasomal degradation. In hypoxia, PHD2 inactivation rapidly upregulates FLNA protein levels because of blockage of its proteasomal degradation. FLNA upregulation induces more immature spines, whereas Flna silencing rescues the immature spine phenotype induced by PHD2 inhibition.

  20. 散列算法MD5和SHA-1的比较%Comparison between MD5 and SHA-1

    Institute of Scientific and Technical Information of China (English)

    王泽; 曹莉莎

    2016-01-01

    MD5 and SHA-1 are the two known Hash Algorithm which are widely applied in information security, they are both developed from MD4.This paper introduces their algorithm logic in detail, compares them though simulation experiment ,soft-ware testing, etc. Finally, it draw a conclusion:The SHA-1 algorithm is more secure than the MD5 algorithm, but in the same hardware, SHA-1 is slower than MD5.%MD5和SHA-1是两个已知的广泛应用于信息安全的散列算法,均由MD4发展而来。详细介绍了它们的算法逻辑,并通过模拟实验、软件测试等方式对其在各个方面进行比较,最终得出结论:SHA-1算法比MD5算法的安全性更高,但在同一硬件上,SHA-1比MD5运行的要慢。

  1. Earth and Space Science PhD Employment Trends

    Science.gov (United States)

    Giesler, J. L.

    2001-05-01

    A recent report by the American Geophysical Union and the American Geological Institute, "Earth and Space Science PhDs, Class of 1999" looked at employment trends of recent graduates. Demographically, our graduates are, as a population, older than those who graduated in any other physical science. While almost one-third of graduates are employed in a different subfield than that of their degree, more than 80% of Earth and space science PhDs secure initial employment in the geosciences. Graduates are finding employment in less than 6 months and the unemployment rate has dropped significantly below that of two years ago. The PhD classes of 1996, 1997, and 1998 had ~ 50% of their graduates taking postdoctoral appointments. In 1999, this declined to only 38% postdocs with an increase in permanent employment in both the education and government sectors. Perception of the job market is improving as well. Respondents are considerably happier than they were in 1996.

  2. Mentored peer reviewing for PhD faculty and students.

    Science.gov (United States)

    Xu, Jiayun; Kim, Kyounghae; Kurtz, Melissa; Nolan, Marie T

    2016-02-01

    There is a need for scholars to be prepared as peer reviewers in order to ensure the continual publication of quality science. However, developing the skills to craft a constructive critique can be difficult. In this commentary, we discuss the use of a group peer review mentoring model for PhD students to gain experience in peer review from a faculty member who is experienced in peer review. Central to this model, was the opportunity for each student and faculty mentor to openly discuss their critique of the manuscript. Through this enriching experience, novice researchers were able to learn the elements of a good peer review, better determine a manuscript's substantive contribution to science, and advance the quality of their own manuscript writing. PMID:26746591

  3. The Virtual Observatory Powered PhD Thesis

    CERN Document Server

    Zolotukhin, Ivan

    2010-01-01

    The Virtual Observatory has reached sufficient maturity for its routine scientific exploitation by astronomers. To prove this statement, here I present a brief description of the complete VO-powered PhD thesis entitled "Galactic and extragalactic research with modern surveys and the Virtual Observatory" comprising 4 science cases covering various aspects of astrophysical research. These comprize: (1) homogeneous search and measurement of main physical parameters of Galactic open star clusters in huge multi-band photometric surveys; (2) study of optical-to-NIR galaxy colors using a large homogeneous dataset including spectroscopy and photometry from SDSS and UKIDSS; (3) study of faint low-mass X-ray binary population in modern observational archives; (4) search for optical counterparts of unidentified X-ray objects with large positional uncertainties in the Galactic Plane. All these projects make heavy use of the VO technologies and tools and would not be achievable without them. So refereed papers published i...

  4. Analysis list: ph-d [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ph-d Cell line,Embryo + dm3 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/p...h-d.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/ph-d.5.tsv http://dbarchive.biosciencedbc.jp.../kyushu-u/dm3/target/ph-d.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/ph-d.Cell_line.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/ph-d.Embryo.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/Cell_line.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Embryo.gml ...

  5. Attitude of PhD Students Towards Academic Dishonesty

    Directory of Open Access Journals (Sweden)

    Vilija Grincevičienė

    2011-04-01

    Full Text Available The article describes the problem of academic dishonesty. Looking over the results of research done in foreign countries (the USA, Romania, Poland, it is possible to assert that the ethics of a scientist is a topical problem nowadays not only in Lithuania but also all over the world. The results of pilot research show that although in all curricula, textbooks and other sources it is declared that each researcher or a team must keep to certain ethics rules, not everything goes well. Respondents were first year PhD students of Vilnius Gediminas Technical University (N=51. Taking into account the results, more attention should be paid to the analysis and correction of the situation.

  6. MATLAB simulation software used for the PhD thesis "Acquisition of Multi-Band Signals via Compressed Sensing

    DEFF Research Database (Denmark)

    2014-01-01

    MATLAB simulation software used for the PhD thesis "Acquisition of Multi-Band Signals via Compressed Sensing......MATLAB simulation software used for the PhD thesis "Acquisition of Multi-Band Signals via Compressed Sensing...

  7. Identification of the phd gene cluster responsible for phenylpropanoid utilization in Corynebacterium glutamicum.

    Science.gov (United States)

    Kallscheuer, Nicolai; Vogt, Michael; Kappelmann, Jannick; Krumbach, Karin; Noack, Stephan; Bott, Michael; Marienhagen, Jan

    2016-02-01

    Phenylpropanoids as abundant, lignin-derived compounds represent sustainable feedstocks for biotechnological production processes. We found that the biotechnologically important soil bacterium Corynebacterium glutamicum is able to grow on phenylpropanoids such as p-coumaric acid, ferulic acid, caffeic acid, and 3-(4-hydroxyphenyl)propionic acid as sole carbon and energy sources. Global gene expression analyses identified a gene cluster (cg0340-cg0341 and cg0344-cg0347), which showed increased transcription levels in response to phenylpropanoids. The gene cg0340 (designated phdT) encodes for a putative transporter protein, whereas cg0341 and cg0344-cg0347 (phdA-E) encode enzymes involved in the β-oxidation of phenylpropanoids. The phd gene cluster is transcriptionally controlled by a MarR-type repressor encoded by cg0343 (phdR). Cultivation experiments conducted with C. glutamicum strains carrying single-gene deletions showed that loss of phdA, phdB, phdC, or phdE abolished growth of C. glutamicum with all phenylpropanoid substrates tested. The deletion of phdD (encoding for putative acyl-CoA dehydrogenase) additionally abolished growth with the α,β-saturated phenylpropanoid 3-(4-hydroxyphenyl)propionic acid. However, the observed growth defect of all constructed single-gene deletion strains could be abolished through plasmid-borne expression of the respective genes. These results and the intracellular accumulation of pathway intermediates determined via LC-ESI-MS/MS in single-gene deletion mutants showed that the phd gene cluster encodes for a CoA-dependent, β-oxidative deacetylation pathway, which is essential for the utilization of phenylpropanoids in C. glutamicum. PMID:26610800

  8. MD5加密算法的研究及应用%Research and application of MD5 encryption algorithm

    Institute of Scientific and Technical Information of China (English)

    魏晓玲

    2010-01-01

    针对当前网站建设和系统开发中用户信息等重要数据的安全问题,提出了一种MD5加密算法,可以对用户密码进行加密.MD5加密算法是一种比较常用的单向加密算法,通过对该算法的深入研究,介绍了MD5算法的特性、算法原理及其算法流程,并给出MD5算法在一个具体系统中的实际应用,得出MD5算法是一种非常安全和易用的加密算法.

  9. Reverse Crack of MD5 Encryption and Its Safety Improvement%MD5加密逆向破解及安全性改进

    Institute of Scientific and Technical Information of China (English)

    王雄; 朱志祥; 许辉辉

    2014-01-01

    针对消息摘要算法第五版(Message-Digest Algorithm 5,MD5)不可逆的特性,通过组建Oracle明文数据库、调用MD5函数,建立明文与MD5码之间的一一对应关系,实现了对MD5加密的逆向破解.从应对碰撞攻击和反向查询两方面,总结多种改进措施,提高了MD5加密算法在实际应用中的安全性.

  10. European brown hare syndrome virus in free-ranging European brown hares from Argentina

    DEFF Research Database (Denmark)

    Frolich, K.; Kujawski, G.E.J.G.; Rudolph, M.;

    2003-01-01

    From 1998 to 2000, serum samples of 80 shot European brown hares (Lepus europaeus) from Argentina were examined for antibodies against European brown hare syndrome virus (EBHSV) and 80 spleen samples were tested for EBHSV-antigen by enzyme linked immunosorbent assay (ELISA). Nine hares were posit...... in these hares. This is the first report of antibodies to EBHSV, EBHSV-antigen, and electron microscopy findings in free-ranging European brown hares from South America....

  11. Browns Park NWR Water Use Report- 1997

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 1997. A general background is presented first with water rights information, management...

  12. Browns Park NWR Water Use Report- 1993

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 1993. A general background is presented first with water rights information, management...

  13. Browns Park NWR Water Use Report- 1988

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 1988. A general background is presented first with water rights information, management...

  14. Browns Park NWR Water Use Report- 1989

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 1989. A general background is presented first with water rights information, management...

  15. Browns Park NWR Water Use Report- 1991

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 1991. A general background is presented first with water rights information, management...

  16. Browns Park NWR Water Use Report- 1995

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 1995. A general background is presented first with water rights information, management...

  17. Browns Park NWR Water Use Report- 1992

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 1992. A general background is presented first with water rights information, management...

  18. Browns Park NWR Water Use Report- 1998

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 1998. A general background is presented first with water rights information, management...

  19. Browns Park NWR Water Use Report- 1996

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 1996. A general background is presented first with water rights information, management...

  20. Browns Park NWR Water Use Report- 1994

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 1994. A general background is presented first with water rights information, management...

  1. Browns Park NWR Water Use Report- 1990

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 1990. A general background is presented first with water rights information, management...

  2. Telemetry techniques used on Kodiak brown bear

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report summarizes the results of a study on the techniques used to monitor the movements of Kodiak brown bears instrumented with radio transmitters. Methods...

  3. Mediastinal Parathyroid Adenoma and Brown Tumors

    OpenAIRE

    Bernal, P.; Ucros, G.; Mejia, A

    2012-01-01

    In this report, we describe a rare case of brown tumor and mediastinal parathyroid adenoma. This report emphasizes the value of radionuclide scintigraphy in the setting of persistent disease following parathyroid surgery.

  4. Ezra Brown named Alumni Distinguished Professor

    OpenAIRE

    Cox, Clara B.

    2005-01-01

    The Virginia Tech Board of Visitors conferred the title Alumni Distinguished Professor (ADP) to Ezra "Bud" Brown, professor of mathematics in the College of Science, in recognition of his extraordinary academic citizenship and distinguished service within the Virginia Tech community.

  5. Browns Park NWR Water Use Report- 2012

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 2012. After the creation of the Flaming Gorge Dam, the annual flooding of the Green River ceased...

  6. Browns Park NWR Water Use Report- 2007

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 2007. After the creation of the Flaming Gorge Dam, the annual flooding of the Green River ceased...

  7. Browns Park NWR Water Use Report- 2011

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 2011. After the creation of the Flaming Gorge Dam, the annual flooding of the Green River ceased...

  8. Browns Park NWR Water Use Report- 2010

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 2010. After the creation of the Flaming Gorge Dam, the annual flooding of the Green River ceased...

  9. Browns Park NWR Water Use Report- 2008

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 2008. After the creation of the Flaming Gorge Dam, the annual flooding of the Green River ceased...

  10. Browns Park NWR Water Use Report- 2006

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 2006. After the creation of the Flaming Gorge Dam, the annual flooding of the Green River ceased...

  11. Browns Park NWR Water Use Report- 2005

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 2005. After the creation of the Flaming Gorge Dam, the annual flooding of the Green River ceased...

  12. Browns Park NWR Water Use Report- 2009

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 2009. After the creation of the Flaming Gorge Dam, the annual flooding of the Green River ceased...

  13. Browns Park NWR Water Use Report- 2013

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 2013. After the creation of the Flaming Gorge Dam, the annual flooding of the Green River ceased...

  14. Brown CA et al 2016 Dataset

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset contains the research described in the following publication: Brown, C.A., D. Sharp, and T. Mochon Collura. 2016. Effect of Climate Change on Water...

  15. Brown bear telemetry and trapping: Special report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Brown bear studies were continued during the 1967 field season with emphasis on development of techniques for instrumenting bears with radio transmitters and...

  16. Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation

    OpenAIRE

    Seale, Patrick

    2015-01-01

    Brown and beige adipose tissue is specialized for heat production and can be activated to reduce obesity and metabolic dysfunction in animals. Recent studies also have indicated that human brown fat activity levels correlate with leanness. This has revitalized interest in brown fat biology and has driven the discovery of many new regulators of brown fat development and function. This review summarizes recent advances in our understanding of the transcriptional mechanisms that control brown an...

  17. Candle power at Browns Ferry

    International Nuclear Information System (INIS)

    An account is given of the serious accident that occurred to the Browns Ferry nuclear power station in Alabama on March 22 1975, when a fire caused by an electrician searching for air leaks using a candle caused great damage to the reactor. The fire put several key safety systems out of action and caused problems in shutting down one of the plant's two reactors. The use of a candle for the purpose was regarded as a highly unofficial but time-honoured method. In this case the candle ignited polyurethane foam surrounding some electrical cables, and the fire spread back through the reactor walls. Some alarming features of the fire fighting effort are noted. The use of water finally quickly extinguished the fire. The unconventional means that had to be adopted to shut down the reactors are described. Implications of the accident for other plants are being considered and modifications are suggested. There were no adverse effects on public health and safety. (author)

  18. [Professor Frantisek Por MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].

    Science.gov (United States)

    Mydlík, M; Derzsiová, K

    2010-11-01

    Professor Frantisek Por MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. Por attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. Por continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. Por practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972. PMID:21250499

  19. 基于简化MD5的TFIDF算法%TFIDF Algorithm Based on a Simplified MD5

    Institute of Scientific and Technical Information of China (English)

    刘雅正; 陈受凯; 唐向阳

    2012-01-01

    随着信息技术不断的发展,海量数据的处理效率成为不可逃避的问题.传统的网页分类算法在分类效果上已经相对成熟,所以在这样的背景下从传统网页分类算法中特征值权重算法的效率和代价出发,分析并提出了基于简化MD5的特征值权重算法.有效减少了特征值提取时的比对和最后一次排序的效率,从而提高了整个网页分类的效率.%With the rapid development of information technology, the process efficiency of massive data has become inescapable problem and Web page classification algorithm has matured yet, so from the efficiency and cost of eigenvalue weights algorithm in traditional web page classification algorithm is started. Eigenvalue weights algorithm based on a simplified MD5, and effective in reducing the efficiency of eigenvalue extraction time and the last sort of eigenvalue are analyzed and proposed. Improving the efficiency of the whole Web page classification is presented.

  20. Academic and research misconduct in the PhD: issues for students and supervisors.

    Science.gov (United States)

    Mitchell, Theresa; Carroll, Jude

    2008-02-01

    There are many pressures upon PhD students not least the requirement to make an original or significant contribution to knowledge. Some students, confronted with complex research processes, might adopt practices that compromise standards that are unacceptable within a research community. These practices challenge the PhD student-supervisor relationship and have implication for the individual, the supervisory team, the institution, the awarding body and the wider research context. Discussion relating to misconduct within the PhD is of international importance if the aim is to encourage and facilitate rigorous research practice. Cases involving academic and research misconduct, especially those occurring at PhD level, are likely to become more frequent as numbers of PhD students increase and will demand appropriate, defensible responses from supervisors. Misconduct during PhD study can be difficult to resolve because of lack of clarity in definitions, supervisor naiveté and failure to acknowledge students' decision making limitations. Using scenarios from the first author's supervisory practice to illustrate issues of concern for students and supervisors during PhD supervision, the authors aim to illuminate the importance of engagement with regulatory bodies; problems of knowledge and understanding transfer; culturally specific issues and meanings of academic theft. PMID:17590482

  1. The cultivar-specific expression patterns of MdACS3 gene and apple fruit ripening and quality

    Science.gov (United States)

    Ethylene plays an important role in diverse physiological and developmental processes of plants. In apple, two ethylene biosynthesis genes, MdACS1 and MdACS3, are expressed in fruit tissues. While MdACS1 expresses at late ripening stages, expression of MdACS3 can be detected as early as 6 weeks bef...

  2. The role of cultivar-specific expression patterns of MdACS3 gene on apple fruit ripening and quality

    Science.gov (United States)

    Ethylene plays an important role in diverse physiological and developmental processes of plants. In apple, two ethylene biosynthesis genes, MdACS1 and MdACS3, are expressed in fruit tissues. While MdACS1 expresses at late ripening stages, expression of MdACS3 can be detected as early as 6 weeks befo...

  3. The improvement of cryptography MD5 algorithm%密码学中信息摘要算法MD5的改进

    Institute of Scientific and Technical Information of China (English)

    林平

    2011-01-01

    MD5算法的基础上,针对MD5算法密文是一个32位16进制字符来表示值的特征,提出MD5改进算法,首先采用替换加密算法Md5Replace加密MD5算法密文,隐藏MD5算法密文的特征;再选定替换加密密文中某一位置插入由随机函数算法Md5Random产生定长的字符串得到最后的密文,改变了替换加密密文位数,隐藏了替换加密算法替换规律.在不改变算法效率的前提下,提高算法安全强度.

  4. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Gang G.; Song, Jikui; Wang, Zhanxin; Dormann, Holger L.; Casadio, Fabio; Li, Haitao; Luo, Jun-Li; Patel, Dinshaw J.; Allis, C. David; (MSKCC); (Scripps); (Rockefeller)

    2009-07-21

    Histone H3 lysine4 methylation (H3K4me) has been proposed as a critical component in regulating gene expression, epigenetic states, and cellular identities. The biological meaning of H3K4me is interpreted by conserved modules including plant homeodomain (PHD) fingers that recognize varied H3K4me states. The dysregulation of PHD fingers has been implicated in several human diseases, including cancers and immune or neurological disorders. Here we report that fusing an H3K4-trimethylation (H3K4me3)-binding PHD finger, such as the carboxy-terminal PHD finger of PHF23 or JARID1A (also known as KDM5A or RBBP2), to a common fusion partner nucleoporin-98 (NUP98) as identified in human leukaemias, generated potent oncoproteins that arrested haematopoietic differentiation and induced acute myeloid leukaemia in murine models. In these processes, a PHD finger that specifically recognizes H3K4me3/2 marks was essential for leukaemogenesis. Mutations in PHD fingers that abrogated H3K4me3 binding also abolished leukaemic transformation. NUP98-PHD fusion prevented the differentiation-associated removal of H3K4me3 at many loci encoding lineage-specific transcription factors (Hox(s), Gata3, Meis1, Eya1 and Pbx1), and enforced their active gene transcription in murine haematopoietic stem/progenitor cells. Mechanistically, NUP98-PHD fusions act as 'chromatin boundary factors', dominating over polycomb-mediated gene silencing to 'lock' developmentally critical loci into an active chromatin state (H3K4me3 with induced histone acetylation), a state that defined leukaemia stem cells. Collectively, our studies represent, to our knowledge, the first report that deregulation of the PHD finger, an 'effector' of specific histone modification, perturbs the epigenetic dynamics on developmentally critical loci, catastrophizes cellular fate decision-making, and even causes oncogenesis during mammalian development.

  5. 报文摘要算法MD5的分析与改进

    Institute of Scientific and Technical Information of China (English)

    汪勋亮; 赵春霞; 郭剑辉

    2014-01-01

    MD5算法在数据加密方面有着广泛的应用,但是它无法抵御查字典攻击和差分等攻击。为此本文介绍了报文算法MD5和Base64算法,以及在两种算法的基础上提出了MD5的改进算法,以应对以上被攻击的缺陷。%MD5 encryption algorithm in the data has a wide range of applications,but it can not resist dictionary attacks and differential attacks.This paper introduces the MD5 message digest algorithm and Base64 algorithm,and two algorithms based on the proposed the improved MD5 algorithm,the effect is to deal with the above attack.

  6. Fred Loe, MD, and the history of trachoma.

    Science.gov (United States)

    Feibel, Robert M

    2011-04-01

    Trachoma has been one of the most blinding diseases in the history of ophthalmology. From its initial description in antiquity until the late 1930s, no specific treatment or effective cure had been known, and the only expedient had been to destroy the diseased tissue containing the infectious agent, rendering the disease inactive. Virtually all medical, mechanical, and surgical treatments were unsatisfactory, with cure rates of approximately 20%. Therapy for trachoma had barely advanced from the measures used by the ancient Egyptian, Greek, and Roman physicians. All prior therapies became obsolete in 1938 when Fred Loe, MD, working on an American Indian reservation, introduced sulfanilamide as a treatment of trachoma, achieving a 90% cure rate. One of the most unusual aspects of Loe's career was that he had no formal training in ophthalmology and was completely self-taught as an ophthalmologist. PMID:21482877

  7. A workshop on leadership for MD/PhD students

    Directory of Open Access Journals (Sweden)

    Mark D. Cannon

    2011-08-01

    Full Text Available Success in academic medicine requires scientific and clinical aptitude and the ability to lead a team effectively. Although combined MD/PhD training programs invest considerably in the former, they often do not provide structured educational opportunities in leadership, especially as applied to investigative medicine. To fill a critical knowledge gap in physician-scientist training, the Vanderbilt Medical Scientist Training Program (MSTP developed a biennial two-day workshop in investigative leadership. MSTP students worked in partnership with content experts to develop a case-based curriculum and deliver the material. In its initial three offerings in 2006, 2008, and 2010, the workshop was judged by MSTP student attendees to be highly effective. The Vanderbilt MSTP Leadership Workshop offers a blueprint for collaborative student-faculty interactions in curriculum design and a new educational modality for physician-scientist training.

  8. Thermal Sensitivity of MD Hematite: Implication for Magnetic Anomalies

    Science.gov (United States)

    Kletetschka, Gunther; Wasilewski, Peter J.; Taylor, Patrick T.

    1999-01-01

    Magnetic remanence of crustal rocks can reside in three common rock-forming magnetic minerals: magnetite, pyrrhotite, and hematite. Thermoremanent magnetization (TRM) of magnetite and pyrrhotite is carried mostly by single domain (SD) grains. The TRM of hematite grains, however, is carried mostly by multidomain (NM) grains. This characteristic is illustrated by TRM acquisition curves for hematite of variable grainsizes. The transition between truly NM behavior and tendency towards SD behavior his been established between hematite grainsizes of 0. 1 and 0.05 mm. Coarse grainsize of lower crustal rocks and the large sensitivity of MD hematite grains to acquire TRM indicates that hematite could be a significant contributor to long-wavelength magnetic anomalies.

  9. BayesMD: flexible biological modeling for motif discovery

    DEFF Research Database (Denmark)

    Tang, Man-Hung Eric; Krogh, Anders; Winther, Ole

    2008-01-01

    and the marginal probabilities can be used directly to assess the significance of the findings. The framework is benchmarked against other methods on a number of real and artificial data sets. The accompanying prediction server, documentation, software, models and data are available from http://bayesmd.binf.ku.dk/.......We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained...... sampling results are achieved using the advanced sampling method parallel tempering. In a post-analysis step candidate motifs with high marginal probability are found by searching among those motifs that contain sites that occur frequently. Thereby, maximum a posteriori inference for the motifs is avoided...

  10. Plasticity and Failure in Nanocrystalline BCC Metals via MD Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Rudd, R E

    2010-02-12

    Advances in the ability to generate extremely high pressures in dynamic experiments such as at the National Ignition Facility has motivated the need for special materials optimized for those conditions as well as ways to probe the response of these materials as they are deformed. We need to develop a much deeper understanding of the behavior of materials subjected to high pressure, especially the effect of rate at the extremely high rates encountered in those experiments. Here we use large-scale molecular dynamics (MD) simulations of the high-rate deformation of nanocrystalline tantalum at pressures less than 100 GPa to investigate the processes associated with plastic deformation for strains up to 100%. We focus on 3D polycrystalline systems with typical grain sizes of 10-20 nm. We also study a rapidly quenched liquid (amorphous solid) tantalum. We apply a constant volume (isochoric), constant temperature (isothermal) shear deformation over a range of strain rates, and compute the resulting stress-strain curves to large strains for both uniaxial and biaxial compression. We study the rate dependence and identify plastic deformation mechanisms. The identification of the mechanisms is facilitated through a novel technique that computes the local grain orientation, returning it as a quaternion for each atom. This analysis technique is robust and fast, and has been used to compute the orientations on the fly during our parallel MD simulations on supercomputers. We find both dislocation and twinning processes are important, and they interact in the weak strain hardening in these extremely fine-grained microstructures. We also present some results on void growth in nanocrystalline BCC metals under tension.

  11. Strategy formulation for the Phd Health Market (Pty) Ltd franchise group / Henk Heath

    OpenAIRE

    Heath, Henk

    2007-01-01

    Phd Health Market (Pty) Ltd was born from the vision of Anton Dupper and Advocate Jan Grobler, to turn a health store in Welkom, South Africa, into a national health franchise in the health & fitness industry. Phd Health Market has a vision to radically change society as a whole by changing nutritional eating and instilling a healthy lifestyle as a whole, which could be easily adapted by all. Phd Health Market is a small developing franchise group, requiring a much needed strategic plan in or...

  12. Creating entrepreneurial networks : academic entrepreneurship, mobility and collaboration during PhD education

    OpenAIRE

    Bienkowska, Dzamila; Klofsten, Magnus

    2012-01-01

    Network-building activities of PhD students are an important area of study in furthering our understanding of academic entrepreneurship. This paper focuses on PhD students’ participation in network-building activities defined as mobility and collaboration, as well as own interest in and perceived grade of support for commercialisation from various levels of the university hierarchy. The results of a large-scale survey (of 1,126 PhD students at Linköping University, Sweden, 41% response rate) ...

  13. WEB登录系统中MD5加密算法的PHP实现%PHP Implementation of MD5 Encryption Algorithm in WEB Login System

    Institute of Scientific and Technical Information of China (English)

    王雄; 李旭辉; 许琳华

    2011-01-01

    MD5是web应用程序中常用的加密算法,很多网站的登录模块都采用了MD5加密,用户登录密码通过使用它加密存储到数据库当中,在一定程度上使入侵者不易获得用户登录权限.本文分析比较了中MD5不同的改进算法,并给出了最后的结论.

  14. European brown hare syndrome virus in free-ranging European brown hares from Argentina

    DEFF Research Database (Denmark)

    Frolich, K.; Kujawski, G.E.J.G.; Rudolph, M.; Rønsholt, L.; Speck, S.

    2003-01-01

    From 1998 to 2000, serum samples of 80 shot European brown hares (Lepus europaeus) from Argentina were examined for antibodies against European brown hare syndrome virus (EBHSV) and 80 spleen samples were tested for EBHSV-antigen by enzyme linked immunosorbent assay (ELISA). Nine hares were...

  15. MD&A – Counterpart to or Distraction from Financial Reporting

    OpenAIRE

    Kevin Girdharry; Elena Simonova; Rock Lefebvre

    2011-01-01

    MD&A content has been an ongoing topic of recent debate with the views divided on the impact that regulated content has on the quality of the MD&A. Complexity has amplified as a result of emerging issues of particular importance to investors such as transition to IFRS, the environment and executive compensation. This paper examines companies’ compliance with requirements of the Canadian Securities Administrators for MD&A disclosures, and aims to advance understand on whether following CSA req...

  16. MD-2 determinants of nickel and cobalt-mediated activation of human TLR4.

    Directory of Open Access Journals (Sweden)

    Alja Oblak

    Full Text Available Recent findings unexpectedly revealed that human TLR4 can be directly activated by nickel ions. This activation is due to the coordination of nickel by a cluster of histidine residues on the ectodomain of human TLR4, which is absent in most other species. We aimed to elucidate the role of MD-2 in the molecular mechanism of TLR4/MD-2 activation by nickel, as nickel binding site on TLR4 is remote from MD-2, which directly binds the endotoxin as the main pathological activator of TLR4. We identified MD-2 and TLR4 mutants which abolished TLR4/MD-2 receptor activation by endotoxin but could nevertheless be significantly activated by nickel, which acts in synergy with LPS. Human TLR4/MD-2 was also activated by cobalt ions, while copper and cadmium were toxic in the tested concentration range. Activation of TLR4 by cobalt required MD-2 and was abolished by human TLR4 mutations of histidine residues at positions 456 and 458. We demonstrated that activation of TLR4 by nickel and cobalt ions can trigger both the MyD88-dependent and the -independent pathway. Based on our results we propose that predominantly hydrophobic interactions between MD-2 and TLR4 contribute to the stabilization of the TLR4/MD-2/metal ion complex in a conformation that enables activation.

  17. Precancer: The Beginning and the End of Cancer. Edited by Jules J. Berman, MD, PhD (E-Mail: jjberman1@comcast.net with G. William Moore, MD, PhD. Jones & Bartlett Publishers: Sudbury, MA, USA, 2009; 186 pp; 42.95$; ISBN: 9780763777845

    Directory of Open Access Journals (Sweden)

    Kara L. Kuntz-Melcavage

    2009-12-01

    Full Text Available This concisely written book makes a powerful argument that the focus of research in the cancer field should be shifted from full-stage cancer to the more promising area of precancer. The entire book encompasses less than 200 pages, including an extensive glossary aimed at clarifying terminology with which a person lacking a research background may be unfamiliar. Because explanations of scientific terminology are located in the glossary, Berman and Moore have prevented the book from being too elementary for an advanced scientist. The logical organization of the chapters results in this becoming quite an easy book to read. [...

  18. Brown Adipose Tissue Growth and Development

    Directory of Open Access Journals (Sweden)

    Michael E. Symonds

    2013-01-01

    Full Text Available Brown adipose tissue is uniquely able to rapidly produce large amounts of heat through activation of uncoupling protein (UCP 1. Maximally stimulated brown fat can produce 300 watts/kg of heat compared to 1 watt/kg in all other tissues. UCP1 is only present in small amounts in the fetus and in precocious mammals, such as sheep and humans; it is rapidly activated around the time of birth following the substantial rise in endocrine stimulatory factors. Brown adipose tissue is then lost and/or replaced with white adipose tissue with age but may still contain small depots of beige adipocytes that have the potential to be reactivated. In humans brown adipose tissue is retained into adulthood, retains the capacity to have a significant role in energy balance, and is currently a primary target organ in obesity prevention strategies. Thermogenesis in brown fat humans is environmentally regulated and can be stimulated by cold exposure and diet, responses that may be further modulated by photoperiod. Increased understanding of the primary factors that regulate both the appearance and the disappearance of UCP1 in early life may therefore enable sustainable strategies in order to prevent excess white adipose tissue deposition through the life cycle.

  19. Iterative redundant encryption based on MD5 algorithm%基于MD5的迭代冗余加密算法

    Institute of Scientific and Technical Information of China (English)

    王津涛; 覃尚毅; 王冬梅

    2007-01-01

    MD5报文摘要算法是一种非常流行的加密方案,是对任意长度的消息提取数字指纹或消息摘要的算法,但是,在计算上难以提供两个具有相同数字指纹的不同消息,并难以由给定的数字指纹推算出相应的消息.基于MD5的迭代冗余加密算法对MD5算法进行了扩展,利用了MD5算法的强大安全性,实现了文件加密、解密和数据完整性保护的功能.

  20. MD5算法的过程分析及其C#实现%Process Analysis of MD5 Algorithm and Its C# realization

    Institute of Scientific and Technical Information of China (English)

    杜昌钰

    2008-01-01

    文章对MD5即"Message-Digest Algorithm 5(报文流行的C#对8D5算法进行了具体的实现,给出了一个具体的C#加密实例.虽然MD5因王小云教授在2004国际密码学会议(Crypto'2004)上发表的论文受到了前所未有的冲击,但MD5在一些非关键领域应用还是相当广泛.最后还提出了一些针对MD5现状的解决对策和建议.

  1. Announcing the 2016 Toxins Travel Awards for Post-Doctoral Fellows and Ph.D. Students

    OpenAIRE

    Tesh, Vernon L.

    2016-01-01

    With the goal of promoting the development of early career investigators in the field of toxinology, Toxins welcomed applications for the 2016 Toxins Travel Awards for post-doctoral fellows and Ph.D. students. [...

  2. Announcing the 2016 Toxins Travel Awards for Post-Doctoral Fellows and Ph.D. Students

    Directory of Open Access Journals (Sweden)

    Vernon L. Tesh

    2016-02-01

    Full Text Available With the goal of promoting the development of early career investigators in the field of toxinology, Toxins welcomed applications for the 2016 Toxins Travel Awards for post-doctoral fellows and Ph.D. students. [...

  3. Actualization of the PhD Students' Intercultural Research Competencies in Global Society

    Directory of Open Access Journals (Sweden)

    Inga Dailidiene

    2013-12-01

    Full Text Available globalization is changing the qualitative characteristics of society, affecting both the life and mentality of people. In relevance to globalization, higher education is gaining new dimensions as well. Bologna and Lisbon documents guide and obligate each country to create integrated and harmonious international space of higher education in Europe. phd studies are considered as integral in the higher education structure; therefore, internationalization is a significant imperative for phd studies development. In the process of internationalization, the need for students’ intercultural competencies is widely recognized. Firstly, we suppose that the impact of globalization on internationalization still remains underestimated. Globalization makes internationalization not only more intense, but also qualitatively different. Secondly, there is a lack of systemic analysis on the development of intercultural research competencies in phd studies. We relate the need for intercultural research competencies to the following critical and rhetorical question: ‘Are today’s phd students ready to solve tomorrow’s global problems?’

  4. Trends in landscape research and landscape planning : implications for PhD students

    OpenAIRE

    Tress, G.; Tress, B; Fry, G; Antrop, M

    2005-01-01

    This chapter introduces the contents of the book through an analysis of current trends in landscape research and landscape planning and a discussion of the consequences of these trends for PhD students.

  5. Jamika Burge one of 50 worldwide to receive IBM Ph.D. fellowship

    OpenAIRE

    Crumbley, Liz

    2005-01-01

    Jamika Burge of Rome, Ga., a doctoral student in the Virginia Tech College of Engineering's Department of Computer Science, has been selected to receive an IBM Ph.D. Fellowship for the 2005-2006 academic year.

  6. PhD Wang Xingchu,A Successful Leader of A High-tech Company Reform

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ PhD Wang Xingchu was born in 1962. He is the Board Chairman of Shanghai Biotechnology Industrial Garden Coalition Development Co., Ltd. and the General Manager of Shanghai Hua Xin High-Biotechnology Co., Ltd.

  7. ASP网站用户帐号的MD5加密技术%The Encryption Techniques of MD5 about User Accounts in ASP Web

    Institute of Scientific and Technical Information of China (English)

    田文艳

    2007-01-01

    本文介绍了Asp中的MD5(Message-Digest Algorithm 5)加密技术,分析了它的工作原理及使用过程,并通过具体的使用实例,说明了MD5加密技术在网站开发中的具体实现方法.

  8. Skill development in collaborative research projects: A comparison between PhD students in multi-actor research programs and in traditional trajectories

    NARCIS (Netherlands)

    Wardenaar, T.; Belder, R.; de Goede, M.E.E; Horlings, E.; van den Besselaar, P.

    2014-01-01

    The growing number of PhD students has spurred debates about the societal relevance of PhD training trajectories. The academic labour market does not provide enough jobs and many PhD graduates will have a career outside academia. It has been questioned whether current PhD training trajectories are s

  9. Articulating Expectations for PhD Candidature upon Commencement: Ensuring Supervisor/Student "Best Fit"

    Science.gov (United States)

    Moxham, Lorna; Dwyer, Trudy; Reid-Searl, Kerry

    2013-01-01

    The journey towards completion of a PhD is a bumpy one for many. One of the major factors that influence successful and on-time thesis completion is the relationship that the PhD candidate has with her or his supervisor. This paper presents results from research undertaken using a 12-item survey to collect data from a purposive sample: PhD…

  10. PhD Seminar within the framework of Water Doctoral Network of Engineering and Management

    OpenAIRE

    Kluska, Andreas; Stefan, Catalin

    2013-01-01

    The Water Doctoral Network of Engineering and Management is a bilateral German – Vietnamese academic network with the aim to provide a platform for the development of joint research activities in water sector. Within the framework of the project, the network members organised a series of workshops and seminars targeted especially at PhD students from universities conducting research programs in water-related issues from both countries. The present paper summarises the outcomes of the last PhD...

  11. Education of MSc and PhD Students in Fluid Power and Mechatronics at DTU

    DEFF Research Database (Denmark)

    Conrad, Finn

    1996-01-01

    The paper deals with education of MSc and PhD students in engineering areas fluid power and mechatronics at the Technical Univ of Denmark, DTU, Lyngby. The new education structure and programs for MSc and PhD students adapted to the change and development of technologies. Focus is on two of twent...... industrial enterprises into account. Projects are included covering mathematical modelling, simulation, analysis, experiments, implementation and prototyping....

  12. Report on the International PhD School ''Science and Technology with the E-ELT''

    Science.gov (United States)

    Bono, G.; Hook, I.; Ramsay, S.

    2015-12-01

    This international PhD school in the F. Lucchin cycle was the first to bring together Masters and PhD students with an interest in all aspects of the science and technology of the European Extremely Large Telescope (E-ELT). It was fitting that this school was held within a year of the project formally entering the construction phase. An overview of the topics covered during the school is presented.

  13. The evaluation of reproductive health PhD program in Iran: The input indicators analysis

    OpenAIRE

    AbdiShahshahani, Mahshid; Ehsanpour, Soheila; Yamani, Nikoo; Kohan, Shahnaz

    2014-01-01

    Background: Appropriate quality achievement of a PhD program requires frequent assessment and discovering the shortcomings in the program. Inputs, which are important elements of the curriculum, are frequently missed in evaluations. The purpose of this study was to evaluate the input indicators of reproductive health PhD program in Iran based on the Context, Input, Process, and Product (CIPP) evaluation model. Materials and Methods: This is a descriptive and evaluative study based on the CIPP...

  14. A super-high throughput implementation of MD5 algorithm on FPGA%超高吞吐量MD5算法的FPGA实现

    Institute of Scientific and Technical Information of China (English)

    王臣; 袁焱

    2011-01-01

    In this paper, a novel architecture is proposed to increase the performance of MD5 computing in FPGA , which can achieve a super-high throughput. The scheme is based on full-pipeline for MD5 implementation. Moreover, FIFO cache structure is used for data storage and cooperative computing. The results of simulation and implementation show that the scheme can achieve the theoretical upper bound on throughput. And based on the same platform of FPGA, it outperforms the published scheme with best performance in terms of 77% higher throughput.%为了提高MD5算法在FPGA中实现的运算效率,使之达到超高的数据吞吐量,提出了一种新的全流水线架构,用于实现MD5算法.架构中使用了FIFO缓存存储数据,以配合流水线的运算.实验验证其达到了单个MD5运算单元运算吞吐量的理论上限,在相同芯片平台上,超过已发表的MD5运算模块最高吞吐量的77%.

  15. Design of MD5 High-Speed Models on FPGA%基于FPGA的MD5高速处理模型设计

    Institute of Scientific and Technical Information of China (English)

    韩津生; 林家骏; 叶建武; 周文锦

    2012-01-01

    In order to improve the performance of MD5 on FPGA, the design concept based on dataflow was proposed. At the design phase, it can assess effectively the specific FPGA, the expected system performance and the specific complex algorithms. Three models of MD5 round were put forward and one of the models was chosen to do experiment. The experimental results indicate that the designed MD5 algorithm could increase efficiently the throughput up to 66. 56 Gbit/s.%为提高MD5的处理速度,提出了基于数据流的设计思想.该思想在设计阶段可以对特定的FPGA、预期的系统性能、复杂的专用算法等进行有效评估.基于该思想,提出了3种不同的MD5节点模型.通过分析,对其中1种模型进行实验,实验验证了基于数据流的设计思想能有效提高MD5的吞吐量,达到66.56 Gbit/s.

  16. 一种使MD5算法产生更强雪崩效应的方法%Generating stronger avalanche effect in MD5 algorithm

    Institute of Scientific and Technical Information of China (English)

    张鑫彦; 闫德勤

    2010-01-01

    通过研究不同的差分分析对MD5算法的攻击后发现,差分分析攻击之所以可以成功,是因为在MD5算法中改变了明文中一些特定位,而这些特定位的改变在许多轮中最多只影响链接变量的几个位,并且这些小的差分能在随后的多轮操作中得到纠正,从而产生了碰撞.这就说明原MD5算法的雪崩效应不能阻止差分分析的攻击,而为了提高MD5算法的安全性,必须提高其雪崩效应的敏感性.分析结果表明,用动态明文变化函数对MD5算法进行修改,能使其产生更敏感的雪崩效应,以此来有效防止差分分析攻击,提高MD5算法的安全性.

  17. Brown adipogenesis of mouse embryonic stem cells in alginate microstrands

    Science.gov (United States)

    Unser, Andrea Mannarino

    The ability of brown adipocytes (fat cells) to dissipate energy as heat shows great promise for the treatment of obesity and other metabolic disorders. Employing pluripotent stem cells, with an emphasis on directed differentiation, may overcome many issues currently associated with primary fat cell cultures. However, brown adipocytes are difficult to transplant in vivo due to the instability of fat, in terms of necrosis and neovascularization, once injected. Thus, 3D cell culture systems that have the potential to mimic adipogenic microenvironments are needed, not only to advance brown fat implantation, but also to better understand the role of brown adipocytes in treating obesity. To address this need, we created 3D "Brown-Fat-in-Microstrands" by microfluidic synthesis of alginate hydrogel microstrands that encapsulated cells and directly induced cell differentiation into brown adipocytes, using mouse embryonic stem cells (ESCs) as a model of pluripotent stem cells and brown preadipocytes as a positive control. The effect of hydrogel formation parameters on brown adipogenesis was studied, leading to the establishment of "Brown-Fat-in-Microstrands". Brown adipocyte differentiation within microstrands was confirmed by lipid droplet accumulation, immunocytochemistry and qPCR analysis of gene expression of brown adipocyte marker uncoupling protein 1 (UCP1) in addition to adipocyte marker expression. Compared to a 2D approach, 3D differentiated "Brown-Fat-in-Microstrands" exhibited higher level of brown adipocyte marker expression. The functional analysis of "Brown-Fat-in-Microstrands" was attempted by measuring the mitochondrial activity of ESC-differentiated brown adipocytes in 3D using Seahorse XF24 3 Extracellular Flux Analyzer. The ability to create "Brown-Fat-in-Microstrands" from pluripotent stem cells opens up a new arena to understanding brown adipogenesis and its implications in obesity and metabolic disorders.

  18. MS PHD'S: Effective Strategies for the Retention and Advancement of URM Students in ESS

    Science.gov (United States)

    Escalera, J.; Burgess, A. K.; Pace, L.; Scott, O.; Strickland, J.; Johnson, A.; Williamson Whitney, V.; Ithier-Guzman, W.

    2012-12-01

    The Minorities Striving and Pursuing Higher Degrees of Success (MS PHD'S) Professional Development Program in Earth system science (ESS) is a model initiative for improving the retention of underrepresented minority (URM) students in STEM fields. Entering its ninth cohort, MS PHD'S remains committed to helping URM undergraduate and graduate students achieve outstanding careers in ESS. MS PHD'S facilitates URM student achievement through a three-phase program designed to increase student exposure to the ESS community. By engaging in a series of professional development and skill building exercises, peer-to-peer community building activities, participation in scientific society conferences and workshops, mentoring by URM and other scientists, and a virtual community, URM students gain the confidence and support necessary to achieve their academic goals and enter the ESS workforce. Since its inception, MS PHD'S continues to support 189 participants. Of these 189 participants, 35 have advanced from undergraduate and graduate academic pathways to completion of their PhD and another 60 are currently enrolled in doctoral programs. MS PHD'S maintains close ties with program alumni to further support retention, inclusivity, and broadening participation of URM students and graduates in STEM activities. Its model is built on reengaging alumni to become mentors and leaders for each new cohort as well as facilitating valuable opportunities for alumni to advance in their ESS related academic and professional career pathways.

  19. PHD2在宫颈病变中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    朱诚程; 周家德; 倪观太; 孙恒亮

    2014-01-01

    目的:研究不同宫颈组织中脯氨酸羟化酶2( PHD2)的表达情况,初步探讨PHD2在宫颈病变中的作用和意义。方法:选取正常宫颈、CINⅠ和CINⅡ、CINⅢ、宫颈癌标本各20例,应用逆转录多聚酶链反应( RT-PCR)、免疫组化法( SP法)检测PHD2 mR-NA和蛋白水平的相对表达情况。结果:正常宫颈、CINⅠ和CINⅡ、CINⅢ、宫颈癌组织中,PHD2蛋白和mRNA表达水平依次上调,两两比较差异均有统计学意义(P<0.01)。结论:PHD2可能参与宫颈病变的发生发展,作为肿瘤标记物用于早期诊断和预后判断。下调PHD2的高表达,可能成为治疗宫颈癌的新靶点。

  20. 78 FR 59060 - Gabriel Sanchez, M.D.; Decision and Order

    Science.gov (United States)

    2013-09-25

    ... any compression of the nerves, or the spinal column, or the nerve root,'' and that it was ``difficult... sufficiently reliable to be accepted and relied upon in this .'' See Cynthia M. Cadet, M.D., 76 FR 19450, 19458... factors are . . . considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003)....

  1. Measurement of Delta-md Using a Probability Based Same-Side Tagger at CDF

    OpenAIRE

    Bauer, G

    2000-01-01

    A measurement of Delta m_d is performed using inclusive lepton+vertex events at CDF. A probability based Same-Side Tagger was developed to tag the initial b-flavor of the B^0_d, which suppresses tagging on B-decay products. We find Delta m_d = 0.42 +/- 0.09 +/- 0.03 ps^-1.

  2. 75 FR 21528 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-04-26

    ... Policies and Procedures (44 FR 11034, February 26, 1979), and 3. Will not have a significant economic... have the same design as those installed on Model MD-90-30 airplanes. Therefore, Model MD-90-30..., hangar lighting, flashlight, or ] droplight and may require removal or opening of access panels or...

  3. 77 FR 67673 - Fernando Valle, M.D.; Decision and Order

    Science.gov (United States)

    2012-11-13

    ... DEA registration. Serenity Caf , 77 FR 35027, 35028 (2012); David W. Wang, 72 FR 54297, 54298 (2007); Sheran Arden Yeates, 71 FR 39130, 39131 (2006); Dominick A. Ricci, M.D., 58 FR 51104 (1993); Bobby Watts, M.D., 53 FR 11919 (1988). Notwithstanding the foregoing, the Respondent contends that the...

  4. DNA methylation fluctuation induced by virus infection differs between MD-resistant and -susceptible chickens

    Science.gov (United States)

    Marek’s disease (MD) is a lymphoproliferative disease induced by Marek’s disease virus (MDV). To augment vaccination, the host genetic resistance is of importance in MD control. While researchers have been largely focused on exploring the genetic differences between resistant and susceptible chicken...

  5. 33 CFR 110.71 - Jacobs Nose Cove, Elk River, Md.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Jacobs Nose Cove, Elk River, Md... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.71 Jacobs Nose Cove, Elk River, Md. The water area of Jacobs Nose Cove, on the west side of the mouth of Elk River, Maryland, comprising the...

  6. Kodiak brown bear population on Kodiak Island, Alaska

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Methods and estimates of the Brown bear population on Kodiak Island. The total number of Kodiak Brown Bears on Kodiak Island has been estimated to be 1669. Three...

  7. Browns Park NWR Water Use Report- 2001 and 2002

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Browns Park NWR for 2001 and 2002. A basic introduction highlighting the region that Browns Park NWR is a part of...

  8. Transport and characterization of ambient biological aerosol near Laurel, MD

    Directory of Open Access Journals (Sweden)

    J. L. Santarpia

    2010-09-01

    Full Text Available Bacterial aerosol have been observed and studied in the ambient environment since the mid nineteenth century. These studies have sought to provide a better understanding of the diversity, variability and factors that control the biological aerosol population. In this study, we show comparisons between diversity of culturable bacteria and fungi, using culture and clinical biochemical tests, and 16S rRNA diversity using Affymetrix PhyloChips. Comparing the culturable fraction and surveying the total 16S rRNA of each sample provides a comprehensive look at the bacterial population studied and allows comparison with previous studies. Thirty-six hour back-trajectories of the air parcels sampled, over the two day period beginning 4 November 2008, provide information on the sources of aerosol sampled on the campus of Johns Hopkins University Applied Physics Laboratory in Laurel, MD. This study indicates that back-trajectory modeling of air parcels may provide insights into the observed diversity of biological aerosol.

  9. The MD simulation of thermal properties of plutonium dioxide

    International Nuclear Information System (INIS)

    The thermodynamic properties of PuO2 have been investigated between 300 and 3000 K by molecular dynamics (MD) simulation with empirical interaction potential. The properties include melting point, lattice parameter variation, enthalpy and heat capacity. The melting point of two-phase simulation (TPS) is in agreement with the experimental value, and it gives a much lower value than one-phase simulation (OPS). The lattice parameter and heat capacity at high temperatures are expressed as a(T)=5.38178+4.38×10-5T+6.5525×10-9T2+0.9362×10-12T3 and CP(KJ⋅mol-1⋅K-1)=18648.8e474.5/T/(T2(e474.5/T-1)2)+9.337×10-6T, respectively. True linear thermal expansion coefficient (TLTEC) α is about 8.89×10-6 K-1 at 300 K. Our simulation results are in good agreement with experimental and other theoretical data.

  10. John Call Dalton, Jr., MD: America's first neurophysiologist.

    Science.gov (United States)

    Fine, E J; Manteghi, T; Sobel, S H; Lohr, L A

    2000-09-26

    Before the discoveries of John Call Dalton, Jr., MD (1824-1889), innervation of laryngeal muscles, long-term effects of cerebellar lesions, and consequences of raised intracranial pressure were poorly understood. Dalton discovered that the posterior cricoarytenoid muscles adducted the vocal cords during inspiration. He confirmed Flourens' observations that acute ablation of the cerebellum of pigeons caused loss of coordination. Dalton observed that properly cared for pigeons gradually recovered "coordinating power." Dalton observed that prolonged raised intracranial pressure caused tachycardia and then fatal bradycardia in dogs. Before Dalton published his photographic atlas of the human brain, neuroanatomy atlases were sketched by Europeans and imported into the United States. Dalton's atlas of the human brain contained precise photographs of vertical and horizontal sections that equal modern works. Before Dalton introduced live demonstrations of animals, physiology was taught by recitation of texts only. Dalton was the first American-born professor to teach physiology employing demonstrations of live animals operated on under ether anesthesia. He wrote an essay advocating experimentation on animals as the proper method of acquiring knowledge of function and that humane animal experimentation would ultimately improve the health of man and animals. His eloquent advocacy for humane experimental physiology quelled attacks by contemporaneous antivivisectionists. Dalton was America's first experimental neurophysiologist. PMID:10994009

  11. From Doctoral Student To Faculty Member: PhD. Project Alumni’s Evaluation Of Their Preparedness

    Directory of Open Access Journals (Sweden)

    Bill N. Schwartz

    2012-03-01

    Full Text Available In response to the important issues regarding diversity in business schools and corporate America, the KPMG Foundation established the PhD Project. The PhD Project helps business professionals and recent college graduates earn doctoral degrees in business disciplines and join business school faculty. While the PhD Project has helped increase the number of minority faculty members in business schools, it may be helpful to gather insights from the recent PhD alumni who have received support from the PhD Project. Our study examines attitudes about preparedness of PhD Project alums for their first faculty position after completing their PhD program. Results show that PhD Project alumni and majority PhD alumni (alumni not associated with the PhD Project felt they were prepared for their first faculty position, but they were not significantly different in their evaluation in most respects. However, to our surprise, majority PhD alumni felt they were better prepared for research than PhD Project alumni. This difference was significant and further analyses showed that younger faculty and those in the ethnic majority were better prepared for research. Both groups considered themselves well prepared for research and teaching. Neither group was as optimistic about being prepared for service responsibilities and the academic climate or politics of an academic career. Our findings show that the PhD Project is necessary to help ensure that minority faculty members are adequately prepared for research and their academic careers.

  12. PRDM16 Controls a Brown Fat/Skeletal Muscle Switch

    OpenAIRE

    Seale, Patrick; Bjork, Bryan; Yang, Wenli; Kajimura, Shingo; Kuang, Shihuan; Scime, Anthony; Devarakonda, Srikripa; Chin, Sherry; Conroe, Heather M.; Erdjument-Bromage, Hediye; Tempst, Paul; Rudnicki, Michael A.; Beier, David R; Spiegelman, Bruce M.

    2008-01-01

    Brown fat can increase energy expenditure and protect against obesity through a specialized program of uncoupled respiration. We show here by in vivo fate mapping that brown but not white fat cells arise from precursors that express myf5, a gene previously thought to be expressed only in the myogenic lineage. Notably, the transcriptional regulator, PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells. Loss of PRDM16 from brown fat precursors causes a...

  13. The brown fat secretome: metabolic functions beyond thermogenesis

    OpenAIRE

    Wang, Guo-Xiao; Zhao, Xu-Yun; Lin, Jiandie D.

    2015-01-01

    Brown fat is highly active in fuel oxidation and dissipates chemical energy through uncoupling protein 1 (UCP1)-mediated heat production. Activation of brown fat leads to increased energy expenditure, reduced adiposity, and lower plasma glucose and lipid levels, thus contributing to better homeostasis. Uncoupled respiration and thermogenesis have been considered to be responsible for the metabolic benefits of brown adipose tissue. Recent studies have demonstrated that brown adipocytes also se...

  14. Professional Socialization for the Ph.D.: An Exploration of Career and Professional Development Preparedness and Readiness for Ph.D. Candidates

    Science.gov (United States)

    Helm, Matt; Campa, Henry, III; Moretto, Kristin

    2012-01-01

    This study sought to uncover the career readiness and professional development needs of Ph.D. students at a large, Midwestern research university. Findings indicate that career goals of graduate students change over time, skill preparation for academic and non-academic careers continues to be inadequate for many students and professional…

  15. Movement and mortality of stocked brown trout in a stream

    DEFF Research Database (Denmark)

    Aarestrup, Kim; Jepsen, Niels; Koed, Anders;

    2005-01-01

    The movement and mortality of stocked brown trout Salmo trutta were investigated using radio telemetry. Four brown trout left the study area whereas the remaining fish were stationary. After 5 weeks, 13 out of 50 tagged brown trout were still alive in the stream. Surviving fish had a significantly...

  16. THE TRANSCRIPTION FACTOR GATA2 REGULATES DIFFERENTIATION OF BROWN ADIPOCYTES

    Science.gov (United States)

    Brown fat tissue is functionally different than the white fat, since brown fat burns lipid to generate heat for body temperature maintenance. However, brown fat cells share with white fat cells a similar molecular mechanism for fat cell formation. We have demonstrated previously that the GATA family...

  17. Kenai Peninsula Brown Bear Studies : Report of the Interagency Brown Bear Study Team, 1986

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report summarizes work conducted during the 1986 field season on brown bear Ursus arctos from the Kenai Peninsula, Alaska. Ground surveys were conducted to...

  18. Black-Brown Relations: Are Alliances Possible?

    Science.gov (United States)

    Klor de Alva, J. Jorge; West, Cornel

    1997-01-01

    Dialogue between Cornel West and Jorge Klor de Alva explores the question of black-brown alliances, those between African Americans and Hispanic Americans. If minority groups can put aside the difference of skin color and join to combat economic and social racism, they can have far-reaching and meaningful impacts on society. (SLD)

  19. From a Brown to a Green Economy

    DEFF Research Database (Denmark)

    Svendsen, Gert Tinggaard

    2013-01-01

    instruments such as taxes and subsidies. In this way, renewable energy sources and green industries become more competitive, thus enhancing the transition from brown to green economy. Not only can these economic incentives accelerate the so-called switch point in time from fossil fuel–based energy sources to...

  20. The White, the Brite and the Brown

    DEFF Research Database (Denmark)

    Pedersen, Lone Møller

    development, also termed adipocyte differentiation, and the role played by adipocytes in wholebody energy metabolism is therefore of utmost importance. Mammals harbour two general types of adipose tissue, white adipose tissue (WAT) and brown adipose tissue (BAT) that carry out essentially opposite functions...

  1. Marilyn Levine: "Brown Boots, Leather Laces."

    Science.gov (United States)

    Williams, Ray

    1988-01-01

    Presents a lesson plan which uses Marilyn Levine's "Brown Boots, Leather Laces" to introduce students in grades 10-12 to naturalistic representation and the "trompe l'oeil" artistic tradition. Discusses Levine's background. Includes instructional strategies and student objectives, as well as a photograph of the artwork. (GEA)

  2. Delay Equation for Charged Brown Particle

    OpenAIRE

    Vlasov, Alexander A.

    2001-01-01

    In previous work (physics/0004026) was shown, with the help of numerical calculations, that the effective Brown temperature for charged particle is lower than that for particle without charge. Here we derive this result without numerical calculations, integrating the delay equation analytically, as for zero, so for nonzero viscosity.

  3. Brown Fat Paucity Due to Impaired BMP Signaling Induces Compensatory Browning of White Fat

    OpenAIRE

    Schulz, Tim J.; Huang, Ping; Huang, Tian Lian; Xue, Ruidan; McDougall, Lindsay E.; Townsend, Kristy L.; Cypess, Aaron M.; Mishina, Yuji; Gussoni, Emanuela; Tseng, Yu-Hua

    2013-01-01

    Summary Maintenance of body temperature is essential for survival of homeotherms. Brown adipose tissue (BAT) is a specialized fat tissue that is dedicated to thermoregulation 1 . Due to its remarkable capacity to dissipate stored energy and its demonstrated presence in adult humans 2-5 , BAT holds great promise for the treatment of obesity and metabolic syndrome 1 . Rodent data suggest the existence of two types of brown fat cells: the constitutive BAT (cBAT), which is of embryonic origin and...

  4. Brown Fat Paucity Due to Impaired BMP Signaling Induces Compensatory Browning of White Fat

    OpenAIRE

    Schulz, Tim J.; Huang, Ping; Huang, Tian Lian; Xue, Ruidan; McDougall, Lindsay E.; Townsend, Kristy L.; Cypess, Aaron M.; Mishina, Yuji; Gussoni, Emanuela; Tseng, Yu-Hua

    2013-01-01

    Summary Maintenance of body temperature is essential for survival of homeotherms. Brown adipose tissue (BAT) is a specialized fat tissue that is dedicated to thermoregulation1. Due to its remarkable capacity to dissipate stored energy and its demonstrated presence in adult humans2-5, BAT holds great promise for the treatment of obesity and metabolic syndrome1. Rodent data suggest the existence of two types of brown fat cells: the constitutive BAT (cBAT), which is of embryonic origin and anato...

  5. Advancing the Integration of Population Medicine into Medical Curricula at The Warren Alpert Medical School of Brown University: A New Master's Degree Program.

    Science.gov (United States)

    Mello, Michael J; Feller, Edward; George, Paul; Borkan, Jeffrey

    2015-09-01

    Additional knowledge, attitudes and skills are required for the next generation of medical students as they expand the traditional focus on individual patients to include population-based health and scholarly investigation. The Warren Alpert Medical School of Brown University (AMS) is initiating a master's degree program as a key component of the new Primary Care-Population Medicine program at AMS leading to both a Doctorate in Medicine (MD) and Master of Science in Population Medicine (ScM) degrees in four years. The ScM is composed of a series of nine courses, integrated into the four-year MD curriculum, as well as a thesis. Additional attention will be given to leadership and quality improvement training. The goal is to produce graduates competent in the care of individual patients, panels, communities, and populations. PMID:26324971

  6. 基于MD5的可逆无冗余加密算法%The Reversible Non-Redundant Encryption Algorithm Based on MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    陈钧; 刘爱华

    2012-01-01

    If MD5 algorithm is directly used to encrypt sensitive data in database, the data is unable to be deerypted by this algorithm itself, even legitimate users query or update some data for the purpose of restoring data. The database becomes more redundant because secret keys need to be saved for reversible encryption algorithms. This paper proposes a reversible non-redundant encryption algorithm based on MD5 algorithm, which can be ~ to used encrypt and decrypt sensitive data in the database regardless of saving secret keys.%直接采用MD5算法对数据库中的敏感数据加密时,合法用户进行查询、更新等操作需要还原数据,MD5算法无法解密数据.可逆的加密算法都需要保存密钥,数据库增加了数据的冗余.本文提出一种基于MD5算法的可逆无冗余算法,实现对数据库中敏感数据进行加密、解密,而且不需要保存密钥.

  7. MD5算法及在用户口令加密应用中的改进%The Improved MD5 Algorithm in the Encryption of User Passwords

    Institute of Scientific and Technical Information of China (English)

    高洪波; 马素萍

    2010-01-01

    MD5是一种非常优秀的加密算法,曾被大量公司和个人广泛使用.但随着科学技术的发展,MD5牢不可破的神话逐渐破灭.基于此,在分析MD5加密算法及其弱点的前提下,探讨了MD5的改进算法.

  8. The Design of MD5 Algorithm against Exhaustion Code-breaking and Its Realization%MD5算法防穷举(冲撞)破译的设计及其实现

    Institute of Scientific and Technical Information of China (English)

    廖思周

    2006-01-01

    在对MD5算法做简单介绍的基础上,针对攻击者拥有巨大密码字典、原文/密文对照数据库,设计了MD5变换算法,是对现有的MD5算法的延伸,大大提高了现成MD5密文的安全性.

  9. Morphogenetics in brown, beige and white fat development.

    Science.gov (United States)

    Lin, Jean Z; Farmer, Stephen R

    2016-01-01

    Brown and beige (or brite) fat cells are capable of evoking non-shivering thermogenesis in response to cold and β-adrenergic stimulation. By metabolizing lipids and carbohydrate via uncoupled respiration these cells directly convert energy to heat. The discovery of brown and brown-like adipocytes in adult humans has reinvigorated interest in stimulating brown and beige fat development to combat the obesity epidemic. This review focuses on the role that cytoskeleton dynamics play in the regulation of adipocyte biology, specifically beige and brown fat development and how newly discovered adipogenic morphogens affect these processes. PMID:27386157

  10. Characterization of an Autophagy-related Gene MdATG8i from apple

    Directory of Open Access Journals (Sweden)

    Ping eWang

    2016-05-01

    Full Text Available Nutrient deficiencies restrict apple (Malus sp. tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway in eukaryotic cells, has important roles in nutrient-recycling and helps improve plant performance during periods of nutrient-starvation. Little is known about the functioning of autophagy-related genes (ATGs in apple. In this study, one of the ATG8 gene family members MdATG8i was isolated from M. domestica. MdATG8i has conserved putative tubulin binding sites and ATG7 interaction domains. A 1865-bp promoter region cloned from apple genome DNA was predicated to have cis-regulatory elements responsive to light, environmental stresses and hormones. MdATG8i transcriptions were induced in response to leaf senescence, nitrogen depletion, and oxidative stress. At cellular level, MdATG8i protein was expressed in the nucleus and cytoplasm of onion epidermal cells. Yeast two-hybrid tests showed that MdATG8i could interact with MdATG7a and MdATG7b. In Arabidopsis, its heterologous expression was associated with enhanced vegetative growth, leaf senescence, and tolerance to nitrogen- and carbon-starvation. MdATG8i-overexpressing ‘Orin’ apple callus lines also displayed improved tolerance to nutrient-limited conditions. Our results demonstrate that MdATG8i protein could function in autophagy in a conserved way, as a positive regulator in the response to nutrient-starvation.

  11. On the Importance of PhD Institute in Establishing a Long-Term Research Career in Astronomy

    OpenAIRE

    Gibson, Brad K.; Buxton, Michelle; Vassiliadis, Emanuel; Sevenster, Maartje N.; Jones, D. Heath; Thornberry, Rebecca K.

    1999-01-01

    We have examined the success rates of 19 American, Canadian, Australian, and Dutch graduate programs in producing astronomers. A 20-year baseline was considered (1975-1994), incorporating 897 PhD recipients. The major conclusion from our study is that the fraction of PhD graduates still involved in astronomical research is surprisingly insensitive to the institutional source of one's PhD. With few exception, 55-75% of graduates, regardless of PhD source, remain active in the astronomical rese...

  12. Was it worth it? An empirical analysis of over-education among Ph.D. recipients in Italy

    OpenAIRE

    Giuseppe Lucio Gaeta

    2013-01-01

    This paper aims to provide an empirical examination of factors associated with overeducation among Ph.D. graduates in Italy. Our investigation is based on recently released data collected by the Italian National Institute of Statistics by means of interviews with a large sample of Ph.D. recipients, carried out a few years after they obtained their Ph.D. degree. We measured the mismatch between their current job and previous Ph.D. studies using two direct subjective evaluations of over-educati...

  13. Preparing Postbaccalaureates for Entry and Success in Biomedical PhD Programs.

    Science.gov (United States)

    Hall, Joshua D; Harrell, Jessica R; Cohen, Kimberley W; Miller, Virginia L; Phelps, Patricia V; Cook, Jeanette G

    2016-01-01

    Certain racial and ethnic groups, individuals with disabilities, and those from low socioeconomic backgrounds remain underrepresented (UR) in the biomedical sciences. This underrepresentation becomes more extreme at each higher education stage. To support UR scholars during the critical transition from baccalaureate to PhD, we established an intensive, 1-yr postbaccalaureate training program. We hypothesized that this intervention would strengthen each participant's competitiveness for leading PhD programs and build a foundation of skills and self-efficacy important for success during and after graduate school. Scholar critical analysis skills, lab technique knowledge, and Graduate Record Examination scores all improved significantly during the program. Scholars reported significant confidence growth in 21 of 24 categories related to success in research careers. In 5 yr, 91% (41/45) of scholars transitioned directly into PhD programs. Importantly, 40% (18/45) of participating postbaccalaureate scholars had previously been declined acceptance into graduate school; however, 17/18 of these scholars directly entered competitive PhD programs following our training program. Alumni reported they were "extremely well" prepared for graduate school, and 95% (39/41) are currently making progress to graduation with a PhD. In conclusion, we report a model for postbaccalaureate training that could be replicated to increase participation and success among UR scholars in the biomedical sciences. PMID:27496358

  14. MD5优化算法及安全性分析%Analysis of MD5 Optimization Algorithm and Safety

    Institute of Scientific and Technical Information of China (English)

    张双斌

    2009-01-01

    针对目前MD5基本算法加密结果容易被破解的问题,在研究分析MD5、SHA-1及其系列算法加密原理的基础上,提出一种增加消息摘要长度的优化算法,使得破解时碰撞的概率减少很多倍,增强了系统加密的安全性.安全分析结果表明,MD5优化算法在保留了原算法加密速度的前提下,具有较原算法更好的抗攻击能力.

  15. A High Throughput FPGA Implementation of MD5 Algorithm%一种高吞吐量MD5算法的FPGA实现

    Institute of Scientific and Technical Information of China (English)

    刘凯; 车明; 秦存秀

    2008-01-01

    MD5数字摘要算法在网络安全的诸多方面都得到广泛的应用.由于其串行计算的特点,对MD5算法的加速并不像其它具有并行操作算法那样容易实现.提出了采用4级流水线的结构来提高MD5运算的吞吐量,可以提升至吉比特级.在设计中,参考了分布式存储模型的结构来实现低延迟、低资源消耗及更好的可扩展性.

  16. Application of MD5 Algorithm in Office Automation System%MD5算法在办公自动化系统中的应用

    Institute of Scientific and Technical Information of China (English)

    张智发

    2008-01-01

    该文对办公自动化系统面临的风险进行了分析,介绍了MD5算法的特点和原理,把MD5算法应用于办公自动化系统中,解决了密码保护、信息完整性验证和数字签名等安全问题, 并给出了具体实现方法.

  17. HMAC-MD5的 FPGA 优化与实现%FPGA Optimization and Implementation of HMAC-MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    蔡啸; 李树国

    2015-01-01

    Data integrity and authenticity are very important in field of information security.HMAC-MD5 algorithm is one of the algorithms that achieve this target.The performance of its software implementation is very low and its FPGA hardware implementation is much higher.For the sake of higher throughput,this paper propose a two-to-one structure.As the result,it costs only 33 cycles to process 5 12 bits data.At the same time,the design support three kinds of mode:HMAC-MD5 computation with Key,HMAC-MD5 computation without key,MD5 computation. The design contains many optimization strategies such as pre-computation, microinstruction controller, the resources reuse etc.After synthesizing by Quartus II 13.0 on Stratix III devices,the clock frequency reaches 100 MHz,the throughput reaches 1.55 Gb/s and 1 120 ALUTs logic resources have been used.%在信息安全领域,数据完整性和真实性是十分重要的.HMAC-MD5算法是实现数据完整性和真实性验证的一种算法.HMAC-MD5的软件实现性能较低,而它的 FPGA 硬件实现性能较高.为了提高 FPGA 实现的性能,提出了一种二合一的结构,处理512 bit 数据周期数降低至33拍,提高了吞吐率,同时能够支持 HMAC-MD5带密钥输入和不带密钥输入、单 MD5运算的模式选择.本设计在 Stratix III 器件上使用 QuartusII 13.0进行综合,在使用了预计算、微指令控制器、资源复用等优化策略之后,最终综合出时钟频率为100 MHz,吞吐率达到1.55 Gb/s,逻辑资源使用为1120 ALUTs.

  18. Authentication in Networking Environment Based on LECC and MD5 Algorithm%基于LECC和MD5算法的网络身份认证

    Institute of Scientific and Technical Information of China (English)

    王小冬; 周海燕

    2015-01-01

    MD5算法常用于对远程用户进行身份认证,但其抵挡不了查字典或差分攻击.本文对用户身份进行MD5加密后,再采用LECC对密文进行纠错编码,提高算法抵御防攻击的能力.理论和实践证明,本算法具有较高的安全性和实用价值.

  19. Milestone report on MD potential development for uranium silicide

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Jianguo [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Zhang, Yongfeng [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Hales, Jason Dean [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.

    2016-03-01

    This report summarizes the progress on the interatomic potential development of triuranium-disilicide (U3Si2) for molecular dynamics (MD) simulations. The development is based on the Tersoff type potentials for single element U and Si. The Si potential is taken from the literature and a Tersoff type U potential is developed in this project. With the primary focus on the U3Si2 phase, some other U-Si systems such as U3Si are also included as a test of the transferability of the potentials for binary U-Si phases. Based on the potentials for unary U and Si, two sets of parameters for the binary U-Si system are developed using the Tersoff mixing rules and the cross-term fitting, respectively. The cross-term potential is found to give better results on the enthalpy of formation, lattice constants and elastic constants than those produced by the Tersoff mixing potential, with the reference data taken from either experiments or density functional theory (DFT) calculations. In particular, the results on the formation enthalpy and lattice constants for the U3Si2 phase and lattice constants for the high temperature U3Si (h-U3Si) phase generated by the cross-term potential agree well with experimental data. Reasonable agreements are also reached on the elastic constants of U3Si2, on the formation enthalpy for the low temperature U3Si (m-U3Si) and h-U3Si phases, and on the lattice constants of m-U3Si phase. All these phases are predicted to be mechanically stable. The unary U potential is tested for three metallic U phases (α, β, γ). The potential is found capable to predict the cohesive energies well against experimental data for all three phases. It matches reasonably with previous experiments on the lattice constants and elastic constants of αU.

  20. A Very Cool Pair of Brown Dwarfs

    Science.gov (United States)

    2011-03-01

    Observations with the European Southern Observatory's Very Large Telescope, along with two other telescopes, have shown that there is a new candidate for the coldest known star: a brown dwarf in a double system with about the same temperature as a freshly made cup of tea - hot in human terms, but extraordinarily cold for the surface of a star. This object is cool enough to begin crossing the blurred line dividing small cold stars from big hot planets. Brown dwarfs are essentially failed stars: they lack enough mass for gravity to trigger the nuclear reactions that make stars shine. The newly discovered brown dwarf, identified as CFBDSIR 1458+10B, is the dimmer member of a binary brown dwarf system located just 75 light-years from Earth [1]. The powerful X-shooter spectrograph on ESO's Very Large Telescope (VLT) was used to show that the composite object was very cool by brown dwarf standards. "We were very excited to see that this object had such a low temperature, but we couldn't have guessed that it would turn out to be a double system and have an even more interesting, even colder component," said Philippe Delorme of the Institut de planétologie et d'astrophysique de Grenoble (CNRS/Université Joseph Fourier), a co-author of the paper. CFBDSIR 1458+10 is the coolest brown dwarf binary found to date. The dimmer of the two dwarfs has now been found to have a temperature of about 100 degrees Celsius - the boiling point of water, and not much different from the temperature inside a sauna [2]. "At such temperatures we expect the brown dwarf to have properties that are different from previously known brown dwarfs and much closer to those of giant exoplanets - it could even have water clouds in its atmosphere," said Michael Liu of the University of Hawaii's Institute for Astronomy, who is lead author of the paper describing this new work. "In fact, once we start taking images of gas-giant planets around Sun-like stars in the near future, I expect that many of them

  1. Publication rate and PhD enrolment following a medical pre-graduate research programme

    DEFF Research Database (Denmark)

    Skovgaard, Marlene; Okkels, Niels; Christensen, Mette Krogh;

    2015-01-01

    INTRODUCTION: In the 1990s, the publication and PhD recruitment rates following the Danish pre-graduate research programme (PGRP) in medicine were 54% and 33%, respectively. Updated estimates are unknown. METHODS: All medical students enrolled in the PGRP at the Faculty of Medicine, Aarhus...... PGRP compared to female medical students (28% versus 19%; p < 0.01). Within three and a half years from PGRP initiation, 13% of the research students had enrolled in a PhD programme at Health, and 52% had published ≥ 1 paper with ≥ 1 supervisor. The research student was the first author on 43% of the...... University (Health), Denmark, during 2003-2012 were included (n = 687). The PGRP files were merged with PhD students' files at Health. A systematic literature search was completed for research students who had enrolled during the 2006-2009 period (n = 227). The factors investigated were student age, sex...

  2. GM-PHD Filter Combined with Track-Estimate Association and Numerical Interpolation

    Directory of Open Access Journals (Sweden)

    Jinguang Chen

    2015-01-01

    Full Text Available For the standard Gaussian mixture probability hypothesis density (GM-PHD filter, the number of targets can be overestimated if the clutter rate is too high or underestimated if the detection rate is too low. These problems seriously affect the accuracy of multitarget tracking for the number and the value of measurements and clutters cannot be distinguished and recognized. Therefore, we proposed an improved GM-PHD filter to tackle these problems. Firstly, a track-estimate association was implemented in the filtering process to detect and remove false-alarm targets. Secondly, a numerical interpolation technique was used to compensate the missing targets caused by low detection rate. At the end of this paper, simulation results were presented to demonstrate the proposed GM-PHD algorithm is more effective in estimating the number and state of targets than the previous ones.

  3. Mandibular brown tumor in renal osteodystrophy

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jin Woo; Choi, Bo Ram; Huh, Kyung Hoe; Yi, Won Jin; Choi, Soon Chul [Department of Oral and Maxillofacial Radiology, School of Dentistry, Seoul National University, Seoul (Korea, Republic of); Gang, In Tae [Department of Oral and Maxillofacial Surgery, Kangnam Sacred Heart Hospital, Hallym Medical Center, Seoul (Korea, Republic of)

    2008-12-15

    Brown tumor is a histologically benign lesion that is a serious complication of renal osteodystrophy because it may result in severe deformity and discomfort. We report a case of brown tumor, which occurred in a 35-year-old woman with chronic renal failure, who had been treated with hemodialysis for 14 years. The lesion was found on the lingual side of the mandible. Standard panoramic radiograph showed generally decreased bone mineral density, loss of lamina dura, and thin cortical plates. Computed tomography (CT) revealed multilocular expansible lesions with heterogeneous attenuation in the anterior mandible, as well as generalized trabecular alteration with homogeneous sclerosis, and thinning or obliteration of cortical plates. Excision of the mandibular lesion and curettage of the affected bone were performed.

  4. Recommendations related to Browns Ferry Fire

    International Nuclear Information System (INIS)

    Based on its review of the events transpiring before, during and after the Browns Ferry fire, the Review Group concludes that the probability of disruptive fires of the magnitude of the Browns Ferry event is small, and that there is no need to restrict operation of nuclear power plants for public safety. However, it is clear that much can and should be done to reduce even further the likelihood of disabling fires and to improve assurance of rapid extinguishment of fires that occur. Consideration should be given also to features that would increase further the ability of nuclear facilities to withstand large fires without loss of important functions should such fires occur. The Review Group believes that improvements, especially in the areas of fire prevention and fire control, can and should be made in most existing facilities

  5. How Glassy States Affect Brown Carbon Production?

    Science.gov (United States)

    Liu, P.; Li, Y.; Wang, Y.; Bateman, A. P.; Zhang, Y.; Gong, Z.; Gilles, M. K.; Martin, S. T.

    2015-12-01

    Secondary organic material (SOM) can become light-absorbing (i.e. brown carbon) via multiphase reactions with nitrogen-containing species such as ammonia and amines. The physical states of SOM, however, potentially slow the diffusion of reactant molecules in organic matrix under conditions that semisolids or solids prevail, thus inhibiting the browning reaction pathways. In this study, the physical states and the in-particle diffusivity were investigated by measuring the evaporation kinetics of both water and organics from aromatic-derived SOMs using a quartz-crystal-microbalance (QCM). The results indicate that the SOMs derived from aromatic precursors toluene and m-xylene became solid (glassy) and the in particle diffusion was significantly impeded for sufficiently low relative humidity ( urban atmospheres that ultimately influence the climate and tropospheric photochemistry.

  6. A Mathematic Model That Describes Modes of MdSGHV Transmission within House Fly Populations

    Directory of Open Access Journals (Sweden)

    Celeste R. Vallejo

    2013-11-01

    Full Text Available In this paper it is proposed that one potential component by which the Musca domestica salivary gland hypertrophy virus (MdSGHV infects individual flies is through cuticular damage. Breaks in the cuticle allow entry of the virus into the hemocoel causing the infection. Male flies typically have a higher rate of infection and a higher rate of cuticular damage than females. A model for the transmission of MdSGHV was formulated assuming several potential and recognized means of transmission. The model yields results that are in agreement with field data that measured the infection rate in house flies on dairy farms in Florida. The results from this model indicate that MdSGHV will be maintained at a stable rate within house fly populations and support the future use of MdSGHV as a birth control agent in house fly management.

  7. A Mathematic Model That Describes Modes of MdSGHV Transmission within House Fly Populations.

    Science.gov (United States)

    Vallejo, Celeste R; Lee, Jo Ann; Keesling, James E; Geden, Christopher J; Lietze, Verena-Ulrike; Boucias, Drion G

    2013-01-01

    In this paper it is proposed that one potential component by which the Musca domestica salivary gland hypertrophy virus (MdSGHV) infects individual flies is through cuticular damage. Breaks in the cuticle allow entry of the virus into the hemocoel causing the infection. Male flies typically have a higher rate of infection and a higher rate of cuticular damage than females. A model for the transmission of MdSGHV was formulated assuming several potential and recognized means of transmission. The model yields results that are in agreement with field data that measured the infection rate in house flies on dairy farms in Florida. The results from this model indicate that MdSGHV will be maintained at a stable rate within house fly populations and support the future use of MdSGHV as a birth control agent in house fly management. PMID:26462530

  8. 75 FR 49979 - Tony T. Bui, M.D.; Revocation of Registration

    Science.gov (United States)

    2010-08-16

    ....'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). I ``may rely on any one or a combination of factors... girlfriend admitting to a soft- drink adulteration that never occurred.'' Id. at 32. Moreover, even after...

  9. 76 FR 52865 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

    Science.gov (United States)

    2011-08-24

    ... Marine Events; Patuxent River, Solomons, MD'' in the Federal Register (76 FR 118). We received no... Solomon's Pier. A large spectator fleet is expected during the event. Due to the need for vessel...

  10. Psychological Approach to Young Goodman Brown

    Institute of Scientific and Technical Information of China (English)

    杨秋仙

    2015-01-01

    <正>Compared with other literary approaches we have studied,I think the psychological approach is most suitable for analyzing Yong Goodman Brown written by American romanticism writer Hawthorne.Because psychoanalytical criticism,which is based on Sigmund Freud’s psychoanalysis mode,aims at uncovering the working of the human mind--especially the expression of the unconsciousness.Professor Jiang point out in his article Hawthorne’s Aesthetic Modernity

  11. Human brown fat and obesity: methodological aspects

    OpenAIRE

    WouterDavidVan Marken Lichtenbelt

    2011-01-01

    Much is known about brown adipose tissue in rodents. Its function is to generate heat in response to low environmental temperatures and to diet or overfeeding. The knowledge about BAT in humans is still rather limited despite the recent rediscovery of its functionality in adults. This review highlights the information available on the contribution of BAT in increasing human energy expenditure in relation to obesity. Besides that methodological aspects will be discussed that need special atten...

  12. Human Brown Fat and Obesity: Methodological Aspects

    OpenAIRE

    van Marken Lichtenbelt, Wouter

    2011-01-01

    Much is known about brown adipose tissue (BAT) in rodents. Its function is to generate heat in response to low environmental temperatures and to diet or overfeeding. The knowledge about BAT in humans is still rather limited despite the recent rediscovery of its functionality in adults. This review highlights the information available on the contribution of BAT in increasing human energy expenditure in relation to obesity. Besides that methodological aspects will be discussed that need special...

  13. Orexin modulates brown adipose tissue thermogenesis

    OpenAIRE

    Madden, Christopher J.; Tupone, Domenico; Morrison, Shaun F.

    2012-01-01

    Non-shivering thermogenesis in brown adipose tissue (BAT) plays an important role in thermoregulation. In addition, activations of BAT have important implications for energy homeostasis due to the metabolic consumption of energy reserves entailed in the production of heat in this tissue. In this conceptual overview we describe the role of orexins/hypocretins within the central nervous system in the modulation of thermogenesis in BAT under several physiological conditions. Within this framewor...

  14. Brown fat and vascular heat dissipation

    OpenAIRE

    Warner, Amy; Mittag, Jens

    2014-01-01

    Current efforts to treat obesity and associated disorders focus on the stimulation of energy expenditure by increasing thermogenesis, for instance through activating brown adipose tissue or more recently “beige” or “brite” fat, a relatively novel type of adipose tissue with putative thermogenic potential. In this commentary, we aim to provide an alternative perspective on the current trend of analyzing and manipulating thermogenesis, brought about by our recent publication, in which we invest...

  15. Central Control of Brown Adipose Tissue Thermogenesis

    OpenAIRE

    ShaunF.Morrison

    2012-01-01

    Thermogenesis, the production of heat energy, is an essential component of the homeostatic repertoire to maintain body temperature during the challenge of low environmental temperature and plays a key role in elevating body temperature during the febrile response to infection. Mitochondrial oxidation in brown adipose tissue (BAT) is a significant source of neurally-regulated metabolic heat production in many species from mouse to man. BAT thermogenesis is regulated by neural networks in the c...

  16. Hypothalamic Control of Brown Adipose Tissue Thermogenesis

    OpenAIRE

    Alexandre Caron; Bartness, Timothy J.

    2015-01-01

    It has long been known, in large part from animal studies, that the control of brown adipose tissue (BAT) thermogenesis is insured by the central nervous system, which integrates several stimuli in order to control BAT activation through the sympathetic nervous system (SNS). SNS-mediated BAT activity is governed by diverse neurons found in brain structures involved in homeostatic regulations and whose activity is modulated by various factors including oscillations of energy fluxes. The charac...

  17. Hypothalamic control of brown adipose tissue thermogenesis

    OpenAIRE

    Labbé, Sebastien M.; Caron, Alexandre; Lanfray, Damien; Monge-Rofarello, Boris; Bartness, Timothy J.; Richard, Denis

    2015-01-01

    It has long been known, in large part from animal studies, that the control of brown adipose tissue (BAT) thermogenesis is insured by the central nervous system (CNS), which integrates several stimuli in order to control BAT activation through the sympathetic nervous system (SNS). SNS-mediated BAT activity is governed by diverse neurons found in brain structures involved in homeostatic regulations and whose activity is modulated by various factors including oscillations of energy fluxes. The ...

  18. The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase

    Institute of Scientific and Technical Information of China (English)

    Nan Chen; Oliver Rinner; Dominika Czernik; Katarzyna J Nytko; Dan Zheng; Daniel P Stiehl; Nicola Zamboni; Matthias Gstaiger; Christian Frei

    2011-01-01

    @@ Dear Editor, Oxygen levels are critical for cellular physiology.Under low oxygen (hypoxia),cells increase glycolysis while limiting mitochondrial oxidative metabolism.Such adaptation is largely mediated by the transcription factors HIF,which accumulate under hypoxia [1,2].Prolyl hydroxylase domain proteins (PHD) function as cellular oxygen sensors and target HIF for subsequent degradation under normoxia [2].The PHD/HIF pathway is conserved in Drosophila,where a single prolyl hydroxylase,Fatiga,has been characterized.We have previously reported that Fatiga regulates cellular growth rates in a HIF-independent manner,yet mechanisms remained elusive [3].

  19. Top tips for PhD thesis examination: nurse clinicians, researchers and novices.

    Science.gov (United States)

    Cleary, Michelle; Horsfall, Jan; Hunt, Glenn E

    2012-01-01

    Interestingly, there are very few guidelines in the literature to assist novice nurse PhD examiners. In this paper, we aim to provide information to nurses, researchers or early career academics who have little experience in assessing a university thesis. The article provides background information about recent changes in the university sector; overviews some research on experienced examiners views; presents factors that differentiate between high and low quality PhD theses; and outlines some pointers that may be useful when marking at the doctoral level. PMID:21903305

  20. The Science Impact of Astronomy PhD Granting Departments in the United States

    OpenAIRE

    Kinney, Anne L.

    2008-01-01

    The scientific impact of the research of 36 astronomy PhD granting departments is measured and ranked here. Because of the complex nature of Universities, this study looks at the Universities in two ways; first analyzing the impact of the published work over a 10 year period of the Department which grants the PhD and; second, looking at the impact of the published work as a whole including Laboratories, Centers, and Facilities. The Universities considered in the study are drawn from the 1992 ...

  1. Cytoplasmic inheritance of organelles in brown algae.

    Science.gov (United States)

    Motomura, Taizo; Nagasato, Chikako; Kimura, Kei

    2010-03-01

    Brown algae, together with diatoms and chrysophytes, are a member of the heterokonts. They have either a characteristic life cycle of diplohaplontic alternation of gametophytic and sporophytic generations that are isomorphic or heteromorphic, or a diplontic life cycle. Isogamy, anisogamy and oogamy have been recognized as the mode of sexual reproduction. Brown algae are the characteristic group having elaborated multicellular organization within the heterokonts. In this study, cytoplasmic inheritance of chloroplasts, mitochondria and centrioles was examined, with special focus on sexual reproduction and subsequent zygote development. In oogamy, chloroplasts and mitochondria are inherited maternally. In isogamy, chloroplasts in sporophyte cells are inherited biparentally (maternal or paternal); however, mitochondria (or mitochondrial DNA) derived from the female gamete only remained during zygote development after fertilization. Centrioles in zygotes are definitely derived from the male gamete, irrespective of the sexual reproduction pattern. Female centrioles in zygotes are selectively broken down within 1-2 h after fertilization. The remaining male centrioles play a crucial role as a part of the centrosome for microtubule organization, mitosis, determination of the cytokinetic plane and cytokinesis, as well as for maintaining multicellularity and regular morphogenesis in brown algae. PMID:20145971

  2. Salsalate activates brown adipose tissue in mice.

    Science.gov (United States)

    van Dam, Andrea D; Nahon, Kimberly J; Kooijman, Sander; van den Berg, Susan M; Kanhai, Anish A; Kikuchi, Takuya; Heemskerk, Mattijs M; van Harmelen, Vanessa; Lombès, Marc; van den Hoek, Anita M; de Winther, Menno P J; Lutgens, Esther; Guigas, Bruno; Rensen, Patrick C N; Boon, Mariëtte R

    2015-05-01

    Salsalate improves glucose intolerance and dyslipidemia in type 2 diabetes patients, but the mechanism is still unknown. The aim of the current study was to unravel the molecular mechanisms involved in these beneficial metabolic effects of salsalate by treating mice with salsalate during and after development of high-fat diet-induced obesity. We found that salsalate attenuated and reversed high-fat diet-induced weight gain, in particular fat mass accumulation, improved glucose tolerance, and lowered plasma triglyceride levels. Mechanistically, salsalate selectively promoted the uptake of fatty acids from glycerol tri[(3)H]oleate-labeled lipoprotein-like emulsion particles by brown adipose tissue (BAT), decreased the intracellular lipid content in BAT, and increased rectal temperature, all pointing to more active BAT. The treatment of differentiated T37i brown adipocytes with salsalate increased uncoupled respiration. Moreover, salsalate upregulated Ucp1 expression and enhanced glycerol release, a dual effect that was abolished by the inhibition of cAMP-dependent protein kinase (PKA). In conclusion, salsalate activates BAT, presumably by directly activating brown adipocytes via the PKA pathway, suggesting a novel mechanism that may explain its beneficial metabolic effects in type 2 diabetes patients. PMID:25475439

  3. Brown coal derived products ameliorating soil acidity

    Energy Technology Data Exchange (ETDEWEB)

    Issa, J.; Patti, A.F.; Jackson, W.R. [Monash University, Clayton, Vic. (Australia). Centre for Green Chemistry

    2000-07-01

    Humic acid derived from brown coal, with added calcium, when applied to the soil surface, can increase pH deeper into the soil profile. The humates can move down with water percolating the soil. As they move down the added calcium bound to the humate's cation exchange sites (the acidic oxygen functional groups) can exchange with toxic aluminium ions and ions on exchange sites in the soil. Thus the soil pH is buffered, nutrient transport to plants assisted, and phytotoxic aluminium bound and rendered harmless to plants. K Humate is a commercially available source of humate (ex HRL Agriculture Pty Ltd Australia) derived from brown coal. It can be obtained by the treatment of brown coal with potassium hydroxide. Calsulmag is a commercial treated coal fly ash (also ex HRL Agriculture Pty Ltd) which can be used instead of lime due to its high inorganic calcium and magnesium content. When K humate and Calsulmag are combined in an aqueous mixture, and applied to the surface of an acidic soil, pH is increased (from 3.8 to 4.5) as is exchangeable calcium (30-50%), while exchangeable aluminium is decreased (30-50%), down to a 5 cm depth.

  4. Summary of LHC MD 369: DOROS vs WBTN in IR Stripline BPMs

    CERN Document Server

    Draskovic, Drasko; Calvo Giraldo, Eva; Olexa, Jakub; Gasior, Marek; CERN. Geneva. ATS Department

    2015-01-01

    The aim of this MD is to quantify the impact of the stripline beam position monitor (BPM) directivity with two acquisition chain electronics systems, WBTN (Wide Band Time Normalizer) and DOROS (Diode ORbit and Oscillation System). This impact depends on the relative position and intensity of the two beams at the location of the monitor. This note explains all the procedures of the LHC MD 369, which took place on 20/07/2015 and presents the obtained results.

  5. EMC/FDTD/MD simulation of carrier transport and electrodynamics in two-dimensional electron systems

    OpenAIRE

    Sule, N; Willis, K. J.; Hagness, S. C.; Knezevic, I.

    2014-01-01

    We present the implementation and application of a multiphysics simulation technique to carrier dynamics under electromagnetic excitation in supported two-dimensional electronic systems. The technique combines ensemble Monte Carlo (EMC) for carrier transport with finite-difference time-domain (FDTD) for electrodynamics and molecular dynamics (MD) for short-range Coulomb interactions among particles. We demonstrate the use of this EMC/FDTD/MD technique by calculating the room-temperature dc an...

  6. Productive replication of Malacosoma neustria nucleopolyhedrovirus (ManeNPV) in Md203 cell line

    OpenAIRE

    DEMİR, İsmail; GÜREL, Nurten; NALÇACIOĞLU, Remziye; İNCE, İkbal A.; DEMİRBAĞ, Zihni

    2009-01-01

    A plaque-purified genotypic variant, derived from a field isolate of the Malacosoma neustria nucleopolyhedrovirus (ManeNPV) from Turkey was characterized based on in vitro replication properties in a cell line, Md203 derived from Malacosoma disstria. The life cycle of ManeNPV was studied based on the cytopathic effects (CPEs), polyhedral inclusion body (PIB) formation, budded virus (BV) production, viral DNA replication and polyhedrin protein expression in ManeNPV-infected Md203 cells. Infec...

  7. MD-CTS: An integrated terminology reference of clinical and translational medicine

    OpenAIRE

    Ray, Will; Finamore, Joe; Rastegar-Mojarad, Majid; Kadolph, Chris; Ye, Zhan; Bohne, Jacquie; Xu, Yin; Burish, Dan; Sondelski, Joshua; Easker, Melissa; Finnegan, Brian; Bartkowiak, Barbara; Smith, Catherine Arnott; Tachinardi, Umberto; Mendonca, Eneida A

    2016-01-01

    New vocabularies are rapidly evolving in the literature relative to the practice of clinical medicine and translational research. To provide integrated access to new terms, we developed a mobile and desktop online reference—Marshfield Dictionary of Clinical and Translational Science (MD-CTS). It is the first public resource that comprehensively integrates Wiktionary (word definition), BioPortal (ontology), Wiki (image reference), and Medline abstract (word usage) information. MD-CTS is access...

  8. Cannabidiol promotes browning in 3T3-L1 adipocytes.

    Science.gov (United States)

    Parray, Hilal Ahmad; Yun, Jong Won

    2016-05-01

    Recruitment of the brown-like phenotype in white adipocytes (browning) and activation of existing brown adipocytes are currently being investigated as a means to combat obesity. Thus, a wide variety of dietary agents that contribute to browning of white adipocytes have been identified. The present study was designed to investigate the effects of cannabidiol (CBD), a major nonpsychotropic phytocannabinoid of Cannabis sativa, on induction of browning in 3T3-L1 adipocytes. CBD enhanced expression of a core set of brown fat-specific marker genes (Ucp1, Cited1, Tmem26, Prdm16, Cidea, Tbx1, Fgf21, and Pgc-1α) and proteins (UCP1, PRDM16, and PGC-1α). Increased expression of UCP1 and other brown fat-specific markers contributed to the browning of 3T3-L1 adipocytes possibly via activation of PPARγ and PI3K. In addition, CBD increased protein expression levels of CPT1, ACSL, SIRT1, and PLIN while down-regulating JNK2, SREBP1, and LPL. These data suggest possible roles for CBD in browning of white adipocytes, augmentation of lipolysis, thermogenesis, and reduction of lipogenesis. In conclusion, the current data suggest that CBD plays dual modulatory roles in the form of inducing the brown-like phenotype as well as promoting lipid metabolism. Thus, CBD may be explored as a potentially promising therapeutic agent for the prevention of obesity. PMID:27067870

  9. Parallel cascade selection molecular dynamics (PaCS-MD) to generate conformational transition pathway

    Science.gov (United States)

    Harada, Ryuhei; Kitao, Akio

    2013-07-01

    Parallel Cascade Selection Molecular Dynamics (PaCS-MD) is proposed as a molecular simulation method to generate conformational transition pathway under the condition that a set of "reactant" and "product" structures is known a priori. In PaCS-MD, the cycle of short multiple independent molecular dynamics simulations and selection of the structures close to the product structure for the next cycle are repeated until the simulated structures move sufficiently close to the product. Folding of 10-residue mini-protein chignolin from the extended to native structures and open-close conformational transition of T4 lysozyme were investigated by PaCS-MD. In both cases, tens of cycles of 100-ps MD were sufficient to reach the product structures, indicating the efficient generation of conformational transition pathway in PaCS-MD with a series of conventional MD without additional external biases. Using the snapshots along the pathway as the initial coordinates, free energy landscapes were calculated by the combination with multiple independent umbrella samplings to statistically elucidate the conformational transition pathways.

  10. The role of PHD2 mutations in the pathogenesis of erythrocytosis

    Directory of Open Access Journals (Sweden)

    Gardie B

    2014-07-01

    of EPO transcription. The α subunits of the hypoxia-inducible transcription factor are hydroxylated by three prolyl hydroxylase domain (PHD enzymes, which belong to the iron and 2-oxoglutarate-dependent oxygenase superfamily. Sequence analysis of the genes encoding the PHDs in patients with erythrocytosis has revealed heterozygous germline mutations only occurring in Egl nine homolog 1 (EGLN1, also known as PHD2, the gene that encodes PHD2. To date, 24 different EGLN1 mutations comprising missense, frameshift, and nonsense mutations have been described. The phenotypes associated with the patients carrying these mutations are fairly homogeneous and typically limited to erythrocytosis with normal to elevated EPO. However, exceptions exist; for example, there is one case with development of concurrent paraganglioma (PHD2-H374R. Analysis of the erythrocytosis-associated PHD2 missense mutations has shown heterogeneous results. Structural studies reveal that mutations can affect different domains of PHD2. Some are close to the hypoxia-inducible transcription factor α/2-oxoglutarate or the iron binding sites for PHD2. In silico studies demonstrate that the mutations do not always affect fully conserved residues. In vitro and in cellulo studies showed varying effects of the mutations, ranging from mild effects to severe loss of function. The exact mechanism of a potential tumor-suppressor role for PHD2 still needs to be elucidated. A knockin mouse model expressing the first reported PHD2-P317R mutation recapitulates the phenotype observed in humans (erythrocytosis with inappropriately normal serum EPO levels and demonstrates that haploinsufficiency and partial deregulation of PHD2 is sufficient to cause erythrocytosis. Keywords: PHD2, EGLN1, HIF, hypoxia, erythropoietin, erythrocytosis

  11. Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

    DEFF Research Database (Denmark)

    Madsen, Chris D; Pedersen, Jesper Thorhauge; Venning, Freja A;

    2015-01-01

    , which can be prevented by simultaneous depletion of HIF-1α. Treatment with the PHD inhibitor DMOG in an orthotopic breast cancer model significantly decreases spontaneous metastases to the lungs and liver, associated with decreased tumour stiffness and fibroblast activation. PHD2 depletion in CAFs co...

  12. Models of text mining to measure improvements to doctoral courses suggested by “STELLA” phd survey respondents

    Directory of Open Access Journals (Sweden)

    Pasquale Pavone

    2014-10-01

    Full Text Available We present Text Mining models to thematically categorise and measure the suggestions of  PhD holders on improving PhD programmes in the STELLA survey (Statistiche in TEma di Laureati e LAvoro. The coded responses questionnaire, designed to evaluate the employment opportunities of students and assess their learning experience, included open-ended questions on how to improve PhD programmes. The Corpus analysed was taken from the data of Italian PhD holders between 2005 and 2009 in eight universities (Bergamo, Brescia, Milano Statale, Milano Bicocca, Pisa, Scuola Superiore Sant’Anna, Palermo and Pavia. The usual methodological approach to text analysis allowed us to categorize open-ended proposals of PhD courses improvements in 8 Italian Universities.

  13. Generalised Brown Clustering and Roll-up Feature Generation

    DEFF Research Database (Denmark)

    Derczynski, Leon; Chester, Sean

    2016-01-01

    Brown clustering is an established technique, used in hundreds of computational linguistics papers each year, to group word types that have similar distributional information. It is unsupervised and can be used to create powerful word representations for machine learning. Despite its improbable...... success relative to more complex methods, few have investigated whether Brown clustering has really been applied optimally. In this paper, we present a subtle but profound generalisation of Brown clustering to improve the overall quality by decoupling the number of output classes from the computational...... active set size. Moreover, the generalisation permits a novel approach to feature selection from Brown clusters: We show that the standard approach of shearing the Brown clustering output tree at arbitrary bitlengths is lossy and that features should be chosen instead by rolling up Generalised Brown...

  14. Transcriptional Control of Brown Fat Determination by PRDM16

    OpenAIRE

    Seale, Patrick; Kajimura, Shingo; Yang, Wenli; Chin, Sherry; Rohas, Lindsay; Uldry, Marc; Tavernier, Geneviève; Langin, Dominique; Spiegelman, Bruce M.

    2007-01-01

    Brown fat cells are specialized to dissipate energy and can counteract obesity; however, the transcriptional basis of their determination is largely unknown. We show here that the zinc-finger protein PRDM16 is highly enriched in brown fat cells compared to white fat cells. When expressed in white fat cell progenitors, PRDM16 activates a robust brown fat phenotype including induction of PGC-1α, UCP1 and type 2 deiodinase expression, and a remarkable increase in uncoupled respiration. Transgeni...

  15. Intricate Transcriptional Networks of Classical Brown and Beige Fat Cells

    OpenAIRE

    Park, Jun Hong; Hur, Wonhee; Lee, Sean Bong

    2015-01-01

    Brown adipocytes are a specialized cell type that is critical for adaptive thermogenesis, energy homeostasis, and metabolism. In response to cold, both classical brown fat and the newly identified “beige” or “brite” cells are activated by β-adrenergic signaling and catabolize stored lipids and carbohydrates to produce heat via UCP1. Once thought to be non-existent in adults, recent studies have discovered active classical brown and beige fat cells in humans, thus reinvigorating interest in br...

  16. Completing a PhD by Publication: A Review of Australian Policy and Implications for Practice

    Science.gov (United States)

    Jackson, Denise

    2013-01-01

    There is increasing impetus for higher-degree-by-research students to publish during candidature. Research performance, including higher degree completions and publication output, commonly determines university funding, and doctorates with publishing experience are better positioned for a career in softening academic labour markets. The PhD by…

  17. Learning to Become Teacher Educators: Testimonies of Three PHD Students in China

    Science.gov (United States)

    Yuan, Rui

    2015-01-01

    While there has been an increasing number of graduate students who enter teacher education after obtaining a higher research degree (e.g., PhD or EdD), scant attention has been paid to their professional learning as prospective teacher educators in higher education. To fill this gap, this study, informed by the social theory of learning,…

  18. Training of young researchers and PhD supervisors for the future

    DEFF Research Database (Denmark)

    Kolmos, Anette

    which contributes to break down the usual ways of thinking and to incorporate both intercultural and interdisciplinary principles, and a valued orientation towards trade and industry. The PhD supervisors should also be trained so that light is thrown on the aims, methods and contents of the supervision...

  19. The Impact of Institutional Student Support on Graduation Rates in US Ph.D. Programmes

    Science.gov (United States)

    Bolli, Thomas; Agasisti, Tommaso; Johnes, Geraint

    2015-01-01

    Using National Research Council data, we investigate the determinants of graduation rates in US Ph.D. programmes. We emphasise the impact that support and facilities offered to doctoral students have on completion rates. Significant, strong and positive effects are found for the provision of on-site graduate conferences and dedicated workspace,…

  20. ChemSession'09 - 6. Warsaw Seminar of the PhD Students in Chemistry - Abstracts

    International Nuclear Information System (INIS)

    Book of Abstracts contains short descriptions of presentations 3 lectures and 105 posters presented during ChemSession'09 - 6th Warsaw Seminar of the PhD Students in Chemistry. Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also found

  1. Career-Self Management and Entrepreneurship: An Experience with PhD Students

    Science.gov (United States)

    Pinto, Joana Carneiro; do Ceu Taveira, Maria; Sa, Elisabete

    2012-01-01

    Introduction: This study presents an experience developed with PhD students aimed to analyze the extent to which career self-management should be approached along with entrepreneurship issues to promote students' career development. Method: An intervention group who attended a Career Self-Management Seminar (EG1), a comparison group who attended…

  2. The Focus and Substance of Formative Comment Provided by PhD Examiners

    Science.gov (United States)

    Holbrook, Allyson; Bourke, Sid; Fairbairn, Hedy; Lovat, Terence

    2014-01-01

    In practice and process PhD examination is distinctive, reflecting the high expectations of students whose learning has been directed to their becoming researchers. This article builds on previous research on the examination of Australian theses that revealed that examiners in Science (n?=?542) and Education (n?=?241) provide a substantial…

  3. PhD versus DSW: A Critique of Trends in Social Work Doctoral Education

    Science.gov (United States)

    Howard, Tyriesa

    2016-01-01

    Social work educators are in a phase of reintroducing the doctor of social work (DSW) degree and refining distinctions between PhD and DSW doctoral programs. This article examines how the two options have been prey to a noticeable "seesaw of precedence", resulting in a debatable history of social work's approach to doctoral education…

  4. Imaginaries of "Europe" in the Governmentality of PhD Education

    Science.gov (United States)

    Bergviken Rensfeldt, Annika

    2014-01-01

    This article examines the recent European governing of PhD education by describing and destabilizing how Europe, as a social construct, is inscribed in the governing in multiple ways. Conceptually, it aligns with post-Foucauldian research interests in imaginaries of societies, subjectivities, and politics of knowledge. Based on European policies…

  5. Three new students selected for the ATLAS PhD Grant Scheme

    CERN Multimedia

    Antonella Del Rosso

    2016-01-01

    Initiated in 2013, the ATLAS PhD Grant Scheme aims to enable young, talented and motivated students to work on part of their PhD thesis at CERN. The collaboration has just selected the three students who will start their theses in 2016.   The three students who received the ATLAS grant, which will cover part of their PhD studies. From left to right: Ruth Jacobs (Germany), Artem Basalaev (Russia), Nedaa B I Asbah (Palestine). The ATLAS PhD Grant Scheme was made possible thanks to a large donation by former ATLAS spokespersons Fabiola Gianotti and Peter Jenni, who started the fund with money from the Fundamental Physics Prize they received in 2013. Applications are handled by CERN HR, via this link. The aim of the initiative is to offer a unique educational opportunity to students within the ATLAS collaboration and to give them the possibility to continue their career in particle physics. Selected candidates receive a stipend allowing them to spend one year at CERN, followed by one year at their h...

  6. The Impact of Publishing during PhD Studies on Career Research Publication, Visibility, and Collaborations

    Science.gov (United States)

    Horta, Hugo; Santos, João M.

    2016-01-01

    This study analyzes the impact that publishing during the period of PhD study has on researchers' future knowledge production, impact, and co-authorship. The analysis is based on a representative sample of PhDs from all fields of science working in Portugal. For each researcher in the dataset, we compiled a lifetime publication record and…

  7. Ability, academic climate, and going abroad for work or pursuing a PhD

    NARCIS (Netherlands)

    Bertrand-Cloodt, D.A.M.; Cörvers, F.; Heijke, J.A.M.

    2014-01-01

    We investigate whether a creaming off of highly able students from Dutch universities is taking place. Therefore, we examine the relation between ability and the destination of recent graduates of Dutch universities. Students can choose to continue their academic career by investing in a PhD degree

  8. ChemSession'08 - 5. Warsaw Seminar of the PhD Students in Chemistry - Abstracts

    International Nuclear Information System (INIS)

    Book of Abstracts consists of short descriptions of presentations: 5 lectures and 127 posters presented during ChemSession'08 - 5th Warsaw Seminar of the PhD Students in Chemistry. Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also found

  9. International Students' Motivation to Pursue and Complete a Ph.D. in the U.S.

    Science.gov (United States)

    Zhou, Ji

    2015-01-01

    This study explores what motivates 19 international students to pursue a Ph.D. at a public research university in the U.S. and, more importantly, what motivates them to persist despite unsatisfying socialization. Based on value-expectancy achievement motivation theory, four motivations emerged: intrinsic interest in research, intrinsic interest in…

  10. Re-Envisioning the Arts PhD: Intellectual Entrepreneurship and the Intellectual Arts Leader

    Science.gov (United States)

    Cherwitz, Richard A.; Beckman, Gary D.

    2006-01-01

    The authors of this article contend that most doctoral students in the arts do not fully appreciate the meaning of their PhD, and that the current system of graduate education perpetuates this phenomenon, with each generation of professors passing down their understanding of the doctorate to succeeding generations. The authors argue that what is…

  11. Regulating Emotions and Aiming for a Ph.D.: Excerpts from "Anthropology Matters"

    Science.gov (United States)

    Hovland, Ingie

    2012-01-01

    In this article I will present a range of experiences of graduate socialisation that have been discussed in past articles in the journal "Anthropology Matters". These are the experiences of social anthropology Ph.D. students in the United Kingdom. The overarching theme for the article is "regulating emotions", and the excerpts presented illustrate…

  12. The luminosities of the coldest brown dwarfs

    Energy Technology Data Exchange (ETDEWEB)

    Tinney, C. G. [School of Physics, UNSW Australia, NSW 2052 (Australia); Faherty, Jacqueline K. [Department of Terrestrial Magnetism, Carnegie Institution of Washington, Washington DC 20005 (United States); Kirkpatrick, J. Davy [Infrared Processing and Analysis Center, MS100-22, California Institute of Technology, Pasadena, CA 91125 (United States); Cushing, Mike [Department of Physics and Astronomy, The University of Toledo, OH 43606 (United States); Morley, Caroline V. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Wright, Edward L., E-mail: c.tinney@unsw.edu.au [Department of Physics and Astronomy, UCLA, Los Angeles, CA 90095-1547 (United States)

    2014-11-20

    In recent years, brown dwarfs have been extended to a new Y-dwarf class with effective temperatures colder than 500 K and masses in the range of 5-30 Jupiter masses. They fill a crucial gap in observable atmospheric properties between the much colder gas-giant planets of our own solar system (at around 130 K) and both hotter T-type brown dwarfs and the hotter planets that can be imaged orbiting young nearby stars (both with effective temperatures in the range of 1500-1000 K). Distance measurements for these objects deliver absolute magnitudes that make critical tests of our understanding of very cool atmospheres. Here we report new distances for nine Y dwarfs and seven very late T dwarfs. These reveal that Y dwarfs do indeed represent a continuation of the T-dwarf sequence to both fainter luminosities and cooler temperatures. They also show that the coolest objects display a large range in absolute magnitude for a given photometric color. The latest atmospheric models show good agreement with the majority of these Y-dwarf absolute magnitudes. This is also the case for WISE0855-0714, the coldest and closest brown dwarf to the Sun, which shows evidence for water ice clouds. However, there are also some outstanding exceptions, which suggest either binarity or the presence of condensate clouds. The former is readily testable with current adaptive optics facilities. The latter would mean that the range of cloudiness in Y dwarfs is substantial with most hosting almost no clouds—while others have dense clouds, making them prime targets for future variability observations to study cloud dynamics.

  13. Categorical perception for red and brown.

    Science.gov (United States)

    Witzel, Christoph; Gegenfurtner, Karl R

    2016-04-01

    Recent studies suggest that the widely accepted evidence in support of categorical perception of color may be a confound of effects due to low-level sensory mechanisms that are unrelated to color categories. To reveal genuine category effects, we investigated the category boundary least prone to spurious effects of low-level mechanisms: the boundary between red and brown. We tested for low-level sensory and high-level cognitive effects of categories on color discrimination, while carefully controlling potential factors of color vision that are not related to color categories. First, we established the red-brown boundary through a naming task and measured just-noticeable differences (JNDs) for colors across the boundary. If low-level sensitivity to color differences was categorical, JNDs should decrease toward the boundary. However, this was not the case. Second, we measured performance in terms of response times and error rates in a speeded discrimination task with color pairs that were equalized in discriminability based on the empirical JNDs. There was a boost of performance (lower response times and error rates) for identifying color differences in equally discriminable color pairs, when the colors crossed the boundary. Given the particularity of the red-brown boundary, these results prove that the observed effects were due to color categories rather than low-level visual mechanisms. These findings support the idea that category effects are due to a shift of attention to the linguistic distinction between categories, rather than being a pure product of perception. These category effects do not depend on the hemispheric lateralization of language. (PsycINFO Database Record PMID:26569337

  14. A National Content Analysis of PhD Program Objectives, Structures, and Curricula: Do Programs Address the Full Range of Social Work's Needs?

    Science.gov (United States)

    Drisko, James; Hunnicutt, Christie; Berenson, Laura

    2015-01-01

    The Group for the Advancement of Doctoral Education (GADE) promotes excellence in PhD education in Social Work. GADE's 2013 Quality Guidelines for PhD Programs heavily emphasize preparation for research. Little is known, however, about the details of the contemporary social work PhD program structure and curriculum. Several prior surveys have…

  15. Larger eggs in resident brown trout living in sympatry with anadromous brown trout

    DEFF Research Database (Denmark)

    Olofsson, H.; Mosegaard, Henrik

    1999-01-01

    Freshwater resident brown trout (Salmo trutta L.) in the stream Jorlandaan (southwestern Sweden) had larger eggs (range of actual mean egg wet weights, 65.9-108.5 mg) than both sympatric migratory trout (76.8-84.2 mg) and trout from five other Swedish streams with allopatric resident (23.7-80.1 mg...

  16. The fire at Browns Ferry station

    International Nuclear Information System (INIS)

    A cable fire broke out at Browns Ferry-1 and -2 power station when sealing material which had been used as a make-shift seal for a cable duct caught fire in the course of a leakage test with an open light. Both blocks of the power station were scrammed manually so that nobody was injured and no activity was released. On the basis of the information supplied by NRC and TVA (the operator), the IRS has attemped a tentative evaluation of the incident. The results are presented in a summarized version. Note: a detailed description of the incident as published by the operator is available at ZAED. (orig./AK)

  17. Analysis of Brown camera distortion model

    Science.gov (United States)

    Nowakowski, Artur; Skarbek, Władysław

    2013-10-01

    Contemporary image acquisition devices introduce optical distortion into image. It results in pixel displacement and therefore needs to be compensated for many computer vision applications. The distortion is usually modeled by the Brown distortion model, which parameters can be included in camera calibration task. In this paper we describe original model, its dependencies and analyze orthogonality with regard to radius for its decentering distortion component. We also report experiments with camera calibration algorithm included in OpenCV library, especially a stability of distortion parameters estimation is evaluated.

  18. Human brown fat and obesity: methodological aspects

    Directory of Open Access Journals (Sweden)

    WouterDavidVan Marken Lichtenbelt

    2011-10-01

    Full Text Available Much is known about brown adipose tissue in rodents. Its function is to generate heat in response to low environmental temperatures and to diet or overfeeding. The knowledge about BAT in humans is still rather limited despite the recent rediscovery of its functionality in adults. This review highlights the information available on the contribution of BAT in increasing human energy expenditure in relation to obesity. Besides that methodological aspects will be discussed that need special attention in order to unravel the heat producing capacity of human BAT, the recruitment of the tissue and its functionality.

  19. Evaluation of hydroacid complex in the forward osmosis–membrane distillation (FO–MD) system for desalination

    KAUST Repository

    Wang, Peng

    2015-11-01

    The incorporation of membrane distillation (MD) into forward osmosis (FO) provides process sustainability to regenerate the draw solution and to produce clean water simultaneously. However, the reverse salt flux is the major hurdle in the FO-MD system because it not only reduces the effective osmotic driving force across the membrane but also increases the replenishment cost and scaling issue. For the first time, a hydroacid complex with abundant hydrophilic groups and ionic species is evaluated as the draw solutes in the hybrid FO-MD system consisting of multi-bore PVDF MD membranes for seawater/brackish desalination. In order to evaluate the practicality of the hydroacid complex in the FO-MD system, FO and MD experiments were conducted at elevated temperatures and concentrations. The hydroacid complex has displayed desired properties such as high solubility, low viscosity, excellent thermal stability and minimal reverse salt flux suitable for FO and MD operations. FO-MD desalination process was demonstrated with a highest seawater desalination flux of 6/32 LMH (FO/MD). This study may open up the prospective of employing the hydroacid complex as the draw solute in FO-MD hybrid systems for seawater /brackish desalination. © 2015 Elsevier B.V.

  20. PuReMD-GPU: A reactive molecular dynamics simulation package for GPUs

    Energy Technology Data Exchange (ETDEWEB)

    Kylasa, S.B., E-mail: skylasa@purdue.edu [Department of Elec. and Comp. Eng., Purdue University, West Lafayette, IN 47907 (United States); Aktulga, H.M., E-mail: hmaktulga@lbl.gov [Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, MS 50F-1650, Berkeley, CA 94720 (United States); Grama, A.Y., E-mail: ayg@cs.purdue.edu [Department of Computer Science, Purdue University, West Lafayette, IN 47907 (United States)

    2014-09-01

    We present an efficient and highly accurate GP-GPU implementation of our community code, PuReMD, for reactive molecular dynamics simulations using the ReaxFF force field. PuReMD and its incorporation into LAMMPS (Reax/C) is used by a large number of research groups worldwide for simulating diverse systems ranging from biomembranes to explosives (RDX) at atomistic level of detail. The sub-femtosecond time-steps associated with ReaxFF strongly motivate significant improvements to per-timestep simulation time through effective use of GPUs. This paper presents, in detail, the design and implementation of PuReMD-GPU, which enables ReaxFF simulations on GPUs, as well as various performance optimization techniques we developed to obtain high performance on state-of-the-art hardware. Comprehensive experiments on model systems (bulk water and amorphous silica) are presented to quantify the performance improvements achieved by PuReMD-GPU and to verify its accuracy. In particular, our experiments show up to 16× improvement in runtime compared to our highly optimized CPU-only single-core ReaxFF implementation. PuReMD-GPU is a unique production code, and is currently available on request from the authors.

  1. Implementation of MD5 Fast Crack Based on GPU Cluster%基于GPU集群实现MD5的快速破解

    Institute of Scientific and Technical Information of China (English)

    杨胜斌

    2013-01-01

    从单个GPU异构并行系统来看,其性能还是比较有限,文章阐述了基于GPU集群的CUDA架构实现过程,详细分析基于GPU集群进行MD5快速破解的编译过程,并对破解程序进行测试研究,对其运行结果进行测试和分析,探讨搭建GPU高性能计算集群及其进行MD5算法的快速破解的过程.

  2. The PHD finger of p300 influences its ability to acetylate histone and non-histone targets.

    Science.gov (United States)

    Rack, Johannes G M; Lutter, Timo; Kjæreng Bjerga, Gro Elin; Guder, Corina; Ehrhardt, Christine; Värv, Signe; Ziegler, Mathias; Aasland, Rein

    2014-12-12

    In enzymes that regulate chromatin structure, the combinatorial occurrence of modules that alter and recognise histone modifications is a recurrent feature. In this study, we explored the functional relationship between the acetyltransferase domain and the adjacent bromodomain/PHD finger (bromo/PHD) region of the transcriptional coactivator p300. We found that the bromo/PHD region of p300 can bind to the acetylated catalytic domain in vitro and augment the catalytic activity of the enzyme. Deletion of the PHD finger, but not the bromodomain, impaired the ability of the enzyme to acetylate histones in vivo, whilst it enhanced p300 self-acetylation. A point mutation in the p300 PHD finger that is related to the Rubinstein-Taybi syndrome resulted in increased self-acetylation but retained the ability to acetylate histones. Hence, the PHD finger appears to negatively regulate self-acetylation. Furthermore, our data suggest that the PHD finger has a role in the recruitment of p300 to chromatin. PMID:25158095

  3. File list: Unc.Adp.20.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.Adp.20.AllAg.Brown_preadipocytes mm9 Unclassified Adipocyte Brown preadipocytes... http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.Adp.20.AllAg.Brown_preadipocytes.bed ...

  4. File list: Unc.Adp.50.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.Adp.50.AllAg.Brown_preadipocytes mm9 Unclassified Adipocyte Brown preadipocytes... http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.Adp.50.AllAg.Brown_preadipocytes.bed ...

  5. File list: Unc.Adp.05.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.Adp.05.AllAg.Brown_preadipocytes mm9 Unclassified Adipocyte Brown preadipocytes... http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.Adp.05.AllAg.Brown_preadipocytes.bed ...

  6. MD5和DES算法在市政网络平台中的应用%Municipal network platform based on md5 funtion and DES algrithm

    Institute of Scientific and Technical Information of China (English)

    邓中亮; 曹其可; 葛悦涛

    2011-01-01

    鉴于市政管理数据中包含大量敏感信息,为解决目前移动终端访问市政平台所存在的安全问题,采用MD5和DES算法,设计一移动通信中间件,对现有的网络进行改进以实现平台的安全机制.MD5算法用采实现身份认证过程,DES算法结合非对称加密和数字签名技术来保证信息的安全传输.该中间件可以以动态库的形式集成在客户端设备与市政管委的Web服务器上,因此可以不需要对现有资源进行较大的改动,以较小的代价达到安全性目标,大大降低部署的难度.%As the database of municipal administration contains large amounts of sensitive information, we designed this mobile middleware to optimized the exsiting platform and protected the sensitive data be attacted. This middleware is based on MD5 and DES algorithm. MD5 algorithm is used to implement the authentication process. DES algorithm combined with asymmetric encryption and digital signature to ensure the safety of information transmission. The middleware can be integrated in the client device and the Web server of the municipal in the form of dynamic libraries. You can achieve the security goals without need to carry out major changes to the existing resources, greatly reduced the difficulty of deployment.

  7. 基于CUDA架构的MD5并行分析算法研究%Research of MD5 Parallel Algorithm Based on CUDA

    Institute of Scientific and Technical Information of China (English)

    张伟; 陈田国; 陶志荣

    2009-01-01

    在介绍了CUDA(统一计算设备架构)架构的基础上,给出了一种CUDA架构上进行MD5摘要分析的并行算法.算法有效利用了GPU的并行性和CUDA架构的优势实现了较快的运算速度,测试结果显示优于CPU的算法.

  8. MD5算法与Web口令的安全传输%MD5 Algorithm and Security Transfer of Web Password

    Institute of Scientific and Technical Information of China (English)

    丁振国; 刘斌

    2004-01-01

    在研究了现存的采用单向散列算法对口令加密传输机制的缺点的基础上,提出了一种用MD5算法加密口令的改进方案,不仅实现简单,而且有效地提高了Web认证系统中口令传输的安全性.

  9. 基于MD5与Base64的混合加密算法%MD5-Base64 based hybrid encryption algorithm

    Institute of Scientific and Technical Information of China (English)

    罗江华

    2012-01-01

    介绍了一种基于MD5和Base64的混合加密算法,首先将明文MD5加密得到32位16进制密文,再将32位密文拆分成16个2位16进制数组,并转换成对应的二进制数,最后将16个二进制数组连接成一个128位的2进制数,采用Base64加密原理进行加密.该算法可以避免查询MD5散列值字典获取用户明文密码,更加有效地保证了用户的密码安全,最后给出了算法的PHP实现.%A MD5-Base64 baaed hybrid encryption algorithm was introduced, which encrypted plain text to 32-bit hexadecimal cipher text by MDS encryption, then split this 32-bit hexadecimal into 16 parts, and transformed them into binary Cor each part to join them together as a 128-bit binary, finally, encrypted the 128-bit binary array by using Base64 algorithm. This algorithm can avoid getting user's clear text password by querying MDS hash database, and protect user's password more effectively. This algorithm was described by PHP script language at the fourth section.

  10. The Luminosities of the Coldest Brown Dwarfs

    CERN Document Server

    Tinney, C G; Kirkpatrick, J Davy; Cushing, Mike; Morley, Caroline V; Wright, Edward L

    2014-01-01

    In recent years brown dwarfs have been extended to a new Y-dwarf class with effective temperatures colder than 500K and masses in the range 5-30 Jupiter masses. They fill a crucial gap in observable atmospheric properties between the much colder gas-giant planets of our own Solar System (at around 130K) and both hotter T-type brown dwarfs and the hotter planets that can be imaged orbiting young nearby stars (both with effective temperatures of in the range 1500-1000K). Distance measurements for these objects deliver absolute magnitudes that make critical tests of our understanding of very cool atmospheres. Here we report new distances for nine Y dwarfs and seven very-late T dwarfs. These reveal that Y dwarfs do indeed represent a continuation of the T dwarf sequence to both fainter luminosities and cooler temperatures. They also show that the coolest objects display a large range in absolute magnitude for a given photometric colour. The latest atmospheric models show good agreement with the majority of these ...

  11. Chandra Captures Flare From Brown Dwarf

    Science.gov (United States)

    2000-07-01

    The first flare ever seen from a brown dwarf, or failed star, was detected by NASA's Chandra X-ray Observatory. The bright X-ray flare has implications for understanding the explosive activity and origin of magnetic fields of extremely low mass stars. Chandra detected no X-rays at all from LP 944-20 for the first nine hours of a twelve hour observation, then the source flared dramatically before it faded away over the next two hours. "We were shocked," said Dr. Robert Rutledge of the California Institute of Technology in Pasadena, the lead author on the discovery paper to appear in the July 20 issue of Astrophysical Journal Letters. "We didn't expect to see flaring from such a lightweight object. This is really the 'mouse that roared.'" Chandra LP 944-20 X-ray Image Press Image and Caption The energy emitted in the brown dwarf flare was comparable to a small solar flare, and was a billion times greater than observed X-ray flares from Jupiter. The flaring energy is believed to come from a twisted magnetic field. "This is the strongest evidence yet that brown dwarfs and possibly young giant planets have magnetic fields, and that a large amount of energy can be released in a flare," said Dr. Eduardo Martin, also of Caltech and a member of the team. Professor Gibor Basri of the University of California, Berkeley, the principal investigator for this observation, speculated that the flare "could have its origin in the turbulent magnetized hot material beneath the surface of the brown dwarf. A sub-surface flare could heat the atmosphere, allowing currents to flow and give rise to the X-ray flare -- like a stroke of lightning." LP 944-20 is about 500 million years old and has a mass that is about 60 times that of Jupiter, or 6 percent that of the Sun. Its diameter is about one-tenth that of the Sun and it has a rotation period of less than five hours. Located in the constellation Fornax in the southern skies, LP 944-20 is one of the best studied brown dwarfs because it is

  12. 基于FPGA的MD5算法设计与实现%Design and Implementation of MD5 Algorithm Based on FPGA

    Institute of Scientific and Technical Information of China (English)

    王波涛; 韩国栋; 张效军

    2010-01-01

    MD5算法在网络安全的诸多方面都得到广泛的应用,在一些特殊场合要求计算具有高处理速度,低资源占用率的特点.文中首先介绍了MD5算法的发展历程和算法原理,然后描述了该算法在FPGA上实现的整体架构,分析了其各模块的功能,最后给出了基于Altera公司的Stratix Ⅱ GX系列FPGA的实现结果.通过实验结果可以看出基于FPGA的MD5算法实现具有较高的处理速度和较少的资源占用,并可对设计进行适当修改来实现其它的摘要算法,具有一定的实用价值.

  13. The role of lipids in nonenzymatic browning

    Directory of Open Access Journals (Sweden)

    Zamora, Rosario

    2000-04-01

    Full Text Available The role of lipids in nonenzymatic browning is studied by reviewing oxidized lipid/protein reactions in comparison with other reactions where the production of browning is known: the Maillard reaction, the ascorbic acid browning, and the quinone/amine reactions. The mechanisms proposed in these reactions for production of color and fluorescence, as well as the formation of melanoidins, lipofuscins, and low molecular weight colored products are discussed comparatively, concluding that the role of lipids in these reactions does not seem to be very different to the role of carbohydrates in the Maillard reaction or the phenols in the enzymatic browning. These carbonyl-amine reactions seem to be a group of gradual, partially reversible, universal, and inevitable side reactions in both food and biological systems. However, most of these results were obtained in model systems and additional studies should be carried out in systems closer to real foods or living beings, which should provide a more complete understanding of nonenzymatic browning, and, therefore, to afford a much more comprehensive knowledge of food and human biochemistry.En este trabajo se hace una revisión del papel de los lípidos en el pardeamiento no enzimático de alimentos mediante el estudio de las reacciones proteína/lípido oxidado en comparación con otras reacciones donde ocurre también este oscurecimiento: la reacción de Maillard, el pardeamiento producido por el ácido ascórbico, y las reacciones de las quinonas con los grupos amino. Los mecanismos propuestos para estas reacciones de producción de color y fluorescencia, así como la formación de melanoidinas, lipofuscinas y productos coloreados de bajo peso molecular son discutidos de forma comparada, concluyendo que el papel de los lípidos en estas reacciones no parece ser muy diferente del papel de los carbohidratos en el Maillard o de los fenoles en el pardeamiento enzimático. Estas reacciones carbonil

  14. Web开发中MD5摘要计算的应用——Struts技术实现

    Institute of Scientific and Technical Information of China (English)

    鲁屹华

    2008-01-01

    M05的全称是Message-Digest Algorithm 5(信息-摘要算法),在90年代初由MIT Laboratory for Computer Science和RSA Data Security Inc的Ronald L.Rivest开发出来,经MD2、MD3和MD4发展而来.本文首先介绍了MD5算法的概念.然后阐述了Java语言的java.security包对MD5算法的支持,并基于Sun公司Java 2平台企业版(J2EE)MVC框架Struts技术,针对B/S模式毕业设计选题系统中的学生基本信息注册模块所采用的MD5摘要计算作了详细介绍.

  15. Danmark og Browns britiske værdier

    DEFF Research Database (Denmark)

    Böss, Michael

    2007-01-01

    Om Gordon Browns kampagne for britiske værdier sat i relation til dansk værdidebat. Udgivelsesdato: 15/10......Om Gordon Browns kampagne for britiske værdier sat i relation til dansk værdidebat. Udgivelsesdato: 15/10...

  16. The Troublesome Legacy of "Brown v. Board of Education"

    Science.gov (United States)

    López, Gerardo R.; Burciaga, Rebeca

    2014-01-01

    Purpose: This article reflects on the 60th anniversary of the "Brown v. Board of Education" Supreme Court decision while discussing the significant lessons learned from this and subsequent court decisions. Argument: In this article, we posit that a fundamentally different conversation surrounding the legacy of Brown is needed if we are…

  17. Race to the Top: Transiting Brown Dwarfs and Hot Jupiters

    Science.gov (United States)

    Beatty, Thomas G.

    2015-12-01

    There are currently twelve known transiting brown dwarfs, nine of which orbit single main-sequence stars. These systems give us one of the only ways in which we may directly measure the masses and radii brown dwarfs, which in turn provides strong constraints on theoretical models of brown dwarf interiors and atmospheres. In addition, the transiting brown dwarfs allow us to forge a link between our understanding of transiting hot Jupiters, and our understanding of the field brown dwarf population. Comparing the two gives us a unique avenue to explore the role and interaction of surface gravity and stellar irradiation in the atmospheres of sub-stellar objects. It also allows us to leverage the detailed spectroscopic information we have for field brown dwarfs to interpret the broadband colors of hot Jupiters. This provides us with insight into the L/T transition in brown dwarfs, and the atmospheric chemistry changes that occur in hot Jupiter atmospheres as they cool. I will discuss recent observational results, with a particular focus on the transiting brown dwarf KELT-1b, and suggest how more of these important systems may be discovered in the future.

  18. Integrated Circuitry: Catharine Brown across Gender, Race, and Religion

    Science.gov (United States)

    Nelson, Joshua B.

    2006-01-01

    This article talks about a Cherokee woman named Catharine Brown who was converted to Christianity by missionaries, as well as historical and theoretical contexts regarding the Cherokee. The author presents views from critics, such as Theda Perdue, Carolyn Ross Johnston, and Arnold Krupat, on Catharine Brown's experiences across spheres such as…

  19. Estrogenic effects of phytoestrogens in brown trout (Salmo trutta)

    DEFF Research Database (Denmark)

    Nielsen, Louise Marie; Holbech, Henrik; Bjerregaard, Poul;

    2010-01-01

    , the potential effect of the waterborne phytoestrogens on endemic fish species is largely unknown. In the present investigation, the estrogenic effect of biochanin A was tested in brown trout through water exposure experiments. Juvenile brown trout of both sexes were exposed to different concentrations...

  20. Phytase activity in brown rice during steeping and sprouting

    OpenAIRE

    Ou, Keqin; Cheng, Yongqiang; Xing, Ying; Lin, Li; Nout, Robert; Liang, Jianfen

    2010-01-01

    Phytase in brown rice will be activated and accumulated during seed germination. Changes of phytase activity in brown rice during two stages of germination (steeping and sprouting) affected by process conditions were studied. It was shown that steeping led to significant decrease of phytase activity (p 

  1. Ouabain-sensitive component of brown fat thermogenesis.

    Science.gov (United States)

    Horwitz, B. A.

    1973-01-01

    The study discussed was undertaken to quantify the amount of energy utilized by the ouabain-sensitive Na(+)-K(+) membrane pump during the norepinephrine-induced thermogenesis of brown adipose tissue. The data obtained indicate that the observed inhibition of the catecholamine-induced increase in brown fat thermogenesis by ouabain does not reflect an inhibition of cyclic AMP synthesis.

  2. The topology of foliations formed by the generic K-orbits of a subclass of the indecomposable MD5-groups

    Institute of Scientific and Technical Information of China (English)

    VU Le Anh; HOA Duong Quang

    2009-01-01

    The paper is a continuation of the authors' works in 2007. We consider the MD5-foliations associated to connected and simply connected MD5-groups such that their Lie algebras have 4-dimensional commutative derived ideals. In this study, we give a topological classification of all considered MD5-foliations. A description of these foliations by certain fibrations or suitable actions of R2 and the Connes' C*-algebras of the foliations which come from fibrations are also given.

  3. LHC Transvers Profile Monitors studies (MD on May 6th, 2011)

    CERN Document Server

    Bravin, E; Dehning, B; Emery, J; Lefevre, T; Gras, JJ; Jeff, A; Rabiller, A; Roncarolo, F; Sapinski, M; Kain, V; Pojer, M; Bartosik, H; Salvant, B

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 6-May-2011 (from 2 to 10 a.m.), dedicated to study Wire Scanners (WS), Synchrotron Radiation Monitors (BSRT) and Beam Gas Ionization Monitors (BGI). The MD aimed at performing different studies on the individual monitors as well as at cross calibrating them with beams composed of bunches with different transverse emittances in stable conditions. At the same time, it was possible to perform calibration studies with the Abort Gap Monitor (AGM) and Longitudinal Density Monitor (LDM) that share the extracted light with the BSRT.

  4. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools

    OpenAIRE

    Amy Franciscovich; Dhananjay Vaidya; Joe Doyle; Josh Bolinger; Montserrat Capdevila; Marcus Rice; Leslie Hancock; Tanya Mahr; Mogul, Douglas B.

    2015-01-01

    Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 an...

  5. Usefulness of multidetector-row CT (MD-CT) for assessment of coronary artery stenosis

    International Nuclear Information System (INIS)

    Coronary arteries stenosis were evaluated in 49 cases by volume rendering (VR) and partial maximum intensity projection (partial MIP) using multidetector-row CT (MD-CT). Left main trunk (LMT) and left anterior descending artery (LAD) were less affected by cardiac pulsation artifact and presented good images. Right coronary artery (RCA) was affected by cardiac pulsation artifact and image quality was inferior as compared to left coronary artery (LCA). It is suggested that MD-CT is useful for assessment of coronary artery stenosis, especially LCA. (author)

  6. Computation of shear viscosity of colloidal suspensions by SRD-MD

    Energy Technology Data Exchange (ETDEWEB)

    Laganapan, A. M. K.; Videcoq, A., E-mail: arnaud.videcoq@unilim.fr; Bienia, M. [SPCTS, UMR 7315, ENSCI, CNRS, Centre Européen de la Céramique, 12 rue Atlantis, 87068 Limoges Cedex (France); Ala-Nissila, T. [COMP CoE at the Department of Applied Physics, Aalto University School of Science, P.O. Box 11000, FIN-00076 Aalto, Espoo (Finland); Department of Physics, Brown University, Providence, Rhode Island 02912-1843 (United States); Bochicchio, D.; Ferrando, R. [Dipartimento di Fisica and CNR-IMEM, via Dodecaneso 33, Genova I-16146 (Italy)

    2015-04-14

    The behaviour of sheared colloidal suspensions with full hydrodynamic interactions (HIs) is numerically studied. To this end, we use the hybrid stochastic rotation dynamics-molecular dynamics (SRD-MD) method. The shear viscosity of colloidal suspensions is computed for different volume fractions, both for dilute and concentrated cases. We verify that HIs help in the collisions and the streaming of colloidal particles, thereby increasing the overall shear viscosity of the suspension. Our results show a good agreement with known experimental, theoretical, and numerical studies. This work demonstrates the ability of SRD-MD to successfully simulate transport coefficients that require correct modelling of HIs.

  7. Examine Your Skin

    Medline Plus

    Full Text Available ... Your Skin Watch the video below and in only two minutes, you can learn to examine your skin. A special thanks to Dr. Martin Weinstock, MD, PhD, Professor of Dermatology, Brown University, for permission to use this video. UPDATED: February ...

  8. Brown spider dermonecrotic toxin directly induces nephrotoxicity

    International Nuclear Information System (INIS)

    Brown spider (Loxosceles genus) venom can induce dermonecrotic lesions at the bite site and systemic manifestations including fever, vomiting, convulsions, disseminated intravascular coagulation, hemolytic anemia and acute renal failure. The venom is composed of a mixture of proteins with several molecules biochemically and biologically well characterized. The mechanism by which the venom induces renal damage is unknown. By using mice exposed to Loxosceles intermedia recombinant dermonecrotic toxin (LiRecDT), we showed direct induction of renal injuries. Microscopic analysis of renal biopsies from dermonecrotic toxin-treated mice showed histological alterations including glomerular edema and tubular necrosis. Hyalinization of tubules with deposition of proteinaceous material in the tubule lumen, tubule epithelial cell vacuoles, tubular edema and epithelial cell lysis was also observed. Leukocytic infiltration was neither observed in the glomerulus nor the tubules. Renal vessels showed no sign of inflammatory response. Additionally, biochemical analyses showed such toxin-induced changes in renal function as urine alkalinization, hematuria and azotemia with elevation of blood urea nitrogen levels. Immunofluorescence with dermonecrotic toxin antibodies and confocal microscopy analysis showed deposition and direct binding of this toxin to renal intrinsic structures. By immunoblotting with a hyperimmune dermonecrotic toxin antiserum on renal lysates from toxin-treated mice, we detected a positive signal at the region of 33-35 kDa, which strengthens the idea that renal failure is directly induced by dermonecrotic toxin. Immunofluorescence reaction with dermonecrotic toxin antibodies revealed deposition and binding of this toxin directly in MDCK epithelial cells in culture. Similarly, dermonecrotic toxin treatment caused morphological alterations of MDCK cells including cytoplasmic vacuoles, blebs, evoked impaired spreading and detached cells from each other and from

  9. The use of a Virtual Community to Complement the MS PHD'S Professional Development Program

    Science.gov (United States)

    Nieves, I. U.; Brown, D. C.; Bailey, K.; Easley, R.; Johnson, A.; Ithier, W.; Powell, J. M.; Whitney, V. W.; Pyrtle, A. J.

    2005-12-01

    The aim of the Minorities Striving and Pursuing Higher Degrees of Success in Earth System Sciencer Professional Development Program (MS PHD'S PDP) is to provide professional and mentoring experiences that facilitate the advancement of minorities committed to achieving outstanding Earth system science and engineering careers. The MS PHD'S PDP is structured in three phases that are connected by engagement in virtual community building activities, allowing for continuous peer to peer and mentor to mentee interactions. These activities occur through the use of the MSPHD'S website forum and web cam dialogues. In addition, the virtual community provides the personal and professional support necessary to ensure the success of the students. Examples of interactions within the MSPHD'S PDP virtual community will be presented.

  10. The training, careers, and work of Ph.D. physical scientists: Not simply academic

    Science.gov (United States)

    Smith, Steven J.; Pedersen-Gallegos, Liane; Riegle-Crumb, Catherine

    2002-11-01

    We present an in-depth portrait of the training, careers, and work of recent Ph.D. physical scientists. Use of specialized training varies widely, with about half often using knowledge of their Ph.D. specialty area in their jobs. The use of specialized training does not, however, correlate with job satisfaction. In this and other important measures, there are relatively few differences between "academics" and "nonacademics." Important job skills for all employment sectors include writing, oral presentation, management, data analysis, designing projects, critical thinking, and working in an interdisciplinary context. Rankings given by respondents of graduate training in some of these skill areas were significantly lower than the importance of these skills in the workplace. We also found that the rated quality of graduate training varies relatively little by department or advisor. Finally, although nonacademic aspirations among graduate students are fairly common, these do not appear to be well supported while in graduate school.

  11. Publication ethics from the perspective of PhD students of health sciences: a limited experience.

    Science.gov (United States)

    Arda, Berna

    2012-06-01

    Publication ethics, an important subtopic of science ethics, deals with determination of the misconducts of science in performing research or in the dissemination of ideas, data and products. Science, the main features of which are secure, reliable and ethically obtained data, plays a major role in shaping the society. As long as science maintains its quality by being based on reliable and ethically obtained data, it will be possible to maintain its role in shaping the society. This article is devoted to the presentation of opinions of PhD candidate students in health sciences in Ankara concerning publication ethics. The data obtained from 143 PhD students from the fields of medicine, dentistry, pharmacy and veterinary reveal limited but unique experiences. It also shows that plagiarism is one of the worst issues in the publication ethics from the perspective of these young academics. PMID:21318323

  12. SMC-PHD based multi-target track-before-detect with nonstandard point observations model

    Institute of Scientific and Technical Information of China (English)

    占荣辉; 高彦钊; 胡杰民; 张军

    2015-01-01

    Detection and tracking of multi-target with unknown and varying number is a challenging issue, especially under the condition of low signal-to-noise ratio (SNR). A modified multi-target track-before-detect (TBD) method was proposed to tackle this issue using a nonstandard point observation model. The method was developed from sequential Monte Carlo (SMC)-based probability hypothesis density (PHD) filter, and it was implemented by modifying the original calculation in update weights of the particles and by adopting an adaptive particle sampling strategy. To efficiently execute the SMC-PHD based TBD method, a fast implementation approach was also presented by partitioning the particles into multiple subsets according to their position coordinates in 2D resolution cells of the sensor. Simulation results show the effectiveness of the proposed method for time-varying multi-target tracking using raw observation data.

  13. Strategies for a successful PhD program: words of wisdom from the WJNR Editorial Board.

    Science.gov (United States)

    Conn, Vicki S; Zerwic, Julie; Rawl, Susan; Wyman, Jean F; Larson, Janet L; Anderson, Cindy M; Fahrenwald, Nancy L; Benefield, Lazelle E; Cohen, Marlene Z; Smith, Carol E; Topp, Robert; Markis, Natalie E

    2014-01-01

    Nursing doctoral programs prepare students for research-focused careers within academic settings. The purpose of this Editorial Board Special Article is to provide PhD students and advisors with suggestions for making the most of their doctoral experience. Editorial Board members provide their individual insights on the skills and attributes students must acquire during the course of their doctoral education in order to succeed. The authors provide practical tips and advice on how to excel in a PhD program, including how to select an advisor and a dissertation committee, the importance of attending conferences to increase visibility and develop a network of colleagues, presenting and publishing research while still a student, and balancing work and personal life. Students who take full advantage of the opportunities available to them during the course of their doctoral programs will graduate well prepared to take on the multiple responsibilities of research, teaching, and leadership. PMID:23797100

  14. Browning and graying: novel transcriptional regulators of brown and beige fat tissues and aging

    Directory of Open Access Journals (Sweden)

    Elisabetta eMueller

    2016-03-01

    Full Text Available Obesity represents a major risk factor for the development of a number of metabolic disorders, including cardiovascular disease and type 2 diabetes. Since the discovery that brown and beige fat cells exist in adult humans and contribute to energy expenditure, increasing interest has been devoted to the understanding of the molecular switches turning on calorie utilization. It has been reported that the ability of thermogenic tissues to burn energy declines during aging, possibly contributing to the development of metabolic dysfunction late in life. This review will focus on the recently identified transcriptional modulators of brown and beige cells and will discuss the potential impact of some of these thermogenic factors on age-associated metabolic disorders.

  15. Earth and Space Science Ph.D. Class of 2003 Report released

    Science.gov (United States)

    Keelor, Brad

    AGU and the American Geological Institute (AGI) released on 26 July an employment study of 180 Earth and space science Ph.D. recipients who received degrees from U.S. universities in 2003. The AGU/AGI survey asked graduates about their education and employment, efforts to find their first job after graduation, and experiences in graduate school. Key results from the study include: The vast majority (87%) of 2003 graduates found work in the Earth and space sciences, earning salaries commensurate with or slightly higher than 2001 and 2002 salary averages. Most (64%) graduates were employed within academia (including postdoctoral appointments), with the remainder in government (19%), industry (10%), and other (7%) sectors. Most graduates were positive about their employment situation and found that their work was challenging, relevant, and appropriate for someone with a Ph.D. The percentage of Ph.D. recipients accepting postdoctoral positions (58%) increased slightly from 2002. In contrast, the fields of physics and chemistry showed significant increases in postdoctoral appointments for Ph.D.s during the same time period. As in previous years, recipients of Ph.D.s in the Earth, atmospheric, and ocean sciences (median age of 32.7 years) are slightly older than Ph.D. recipients in most other natural sciences (except computer sciences), which is attributed to time taken off between undergraduate and graduate studies. Women in the Earth, atmospheric,and ocean sciences earned 33% of Ph.D.s in the class of 2003, surpassing the percentage of Ph.D.s earned by women in chemistry (32%) and well ahead of the percentage in computer sciences (20%), physics (19%), and engineering (17%). Participation of other underrepresented groups in the Earth, atmospheric, and ocean sciences remained extremely low.

  16. ChemSession'07 - 4th Seminary of Warsaw PhD Students in Chemistry. Abstracts

    International Nuclear Information System (INIS)

    4th Annual Seminary of Warsaw PhD Students in Chemistry presented the latest achievements in chemistry, obtained in all Warsaw universities and scientific institutes. In 2007 participants presented 4 plenary lectures, and 101 posters. Among others, posters covered four disciplines related to the nuclear sciences: (a) radiobiology and radiotherapy, (b) radiation chemistry and photochemistry, (c) isotopic effects in chemistry, and (d) chemical technology

  17. ChemSession'11 - 8. Warsaw Seminar of the PhD Students in Chemistry - Abstracts

    International Nuclear Information System (INIS)

    Book of Abstracts contains short descriptions of presentations: 4 lectures, 1 communication and 149 posters presented during ChemSession'11 - 8th Warsaw Seminar of the PhD Students in Chemistry (Warsaw, 13.05.2011). Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry, application of the radionuclides and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also mentioned.

  18. PHD fingers in human diseases: Disorders arising from misinterpreting epigenetic marks

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Lindsey A. [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States); Allis, C. David [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States)], E-mail: alliscd@rockefeller.edu; Wang, Gang G. [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States)], E-mail: gwang@rockefeller.edu

    2008-12-01

    Histone covalent modifications regulate many, if not all, DNA-templated processes, including gene expression and DNA damage response. The biological consequences of histone modifications are mediated partially by evolutionarily conserved 'reader/effector' modules that bind to histone marks in a modification- and context-specific fashion and subsequently enact chromatin changes or recruit other proteins to do so. Recently, the Plant Homeodomain (PHD) finger has emerged as a class of specialized 'reader' modules that, in some instances, recognize the methylation status of histone lysine residues, such as histone H3 lysine 4 (H3K4). While mutations in catalytic enzymes that mediate the addition or removal of histone modifications (i.e., 'writers' and 'erasers') are already known to be involved in various human diseases, mutations in the modification-specific 'reader' proteins are only beginning to be recognized as contributing to human diseases. For instance, point mutations, deletions or chromosomal translocations that target PHD fingers encoded by many genes (such as recombination activating gene 2 (RAG2), Inhibitor of Growth (ING), nuclear receptor-binding SET domain-containing 1 (NSD1) and Alpha Thalassaemia and Mental Retardation Syndrome, X-linked (ATRX)) have been associated with a wide range of human pathologies including immunological disorders, cancers, and neurological diseases. In this review, we will discuss the structural features of PHD fingers as well as the diseases for which direct mutation or dysregulation of the PHD finger has been reported. We propose that misinterpretation of the epigenetic marks may serve as a general mechanism for human diseases of this category. Determining the regulatory roles of histone covalent modifications in the context of human disease will allow for a more thorough understanding of normal and pathological development, and may provide innovative therapeutic strategies

  19. Governance configurations and academic outcomes: The example of Ph.D. education

    OpenAIRE

    Schneider, Peter; Sadowski, Dieter

    2010-01-01

    In many European countries efforts are undertaken to improve doctoral education. In the context of new public governance in the Higher Education sector, less state, more competition, less academic self-governance, more internal hierarchy and more influence by external stakeholders under the common roof of New Public Management (NPM) are considered most promising for successful PhD education. Therefore according to a steering model of American research universities many initiatives are underta...

  20. "Essays on International Business Cycles", PhD thesis, Economics Department, University of Chicago, 1991.

    OpenAIRE

    Kollmann, Robert

    1991-01-01

    PhD dissertation, 1991, Economics Department, University of Chicago. (Thesis committee: Michael Woodford, advisor; José Scheinkman; John Huizinga.) Models of the international economy which assume complete asset markets predict that consumption co-moves closely in different countries as this structure of asset markets allows agents in different countries to 'pool' the country-specific risks which they face (see Scheinkman (1984), Leme (1984)). Examples in this class of models include the...

  1. Synthesis of the PhD thesis "Anti-money laundering and counter terrorism financing management"

    OpenAIRE

    Camelia Popa

    2013-01-01

    As a whole, this PhD thesis follows three research lines, namely: (1) the conceptual line - concerns the definition of the money laundering and terrorism financing phenomenon, the processes, mechanisms, stages and instruments of the laundering of illegally obtained fund; (2) the estimative line aimed at measuring the size of money laundering phenomenon, the economic, social and security effects and consequences; (3) the line of an awareness of the need to prevent and fight against the effects...

  2. Bucharest PhD Training School : Modern Aspects of Quantum Field Theory and Applications

    CERN Document Server

    2015-01-01

    Bucharest 2015 – Modern Aspects of Quantum Field Theory is part of the CERN – SEENET-MTP PhD Training Program, which consists of a number of seminars in theoretical high energy Physics. This is the second seminar organized by this Program. Here are some photos from this event held in Bucharest between 8-14 November 2015. The previous seminar was organized in Belgrade, under the name Belgrade 2015 - Supergravity.

  3. ChemSession'06 - 3rd Seminary of Warsaw PhD Students in Chemistry. Abstracts

    International Nuclear Information System (INIS)

    3rd Annual Seminary of Warsaw PhD Students in Chemistry presented the latest achievements in chemistry, obtained in all Warsaw universities and scientific institutes. In 2006 participants presented 4 plenary lectures, and 109 posters. Among others, posters covered four disciplines related to the nuclear sciences: (a) radiobiology and radiotherapy, (b) radiation chemistry and photochemistry, (c) isotopic effects in chemistry, and (d) chemical technology

  4. ChemSession'10: 7. Warsaw Seminar of the PhD Students in Chemistry. Abstracts

    International Nuclear Information System (INIS)

    Book of Abstracts contains short descriptions of presentations 4 lectures and 151 posters presented during ChemSession'10 - 7th Warsaw Seminar of the PhD Students in Chemistry (Warsaw, 14.05.2010). Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry, application of the radionuclides and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also mentioned.

  5. CERGE-EI: The American-style PhD program in economics for transition economies

    Czech Academy of Sciences Publication Activity Database

    Švejnar, Jan

    Washington, DC : International Bank for Reconstruction and Development/The World Bank, 2007 - (Bourguignon, F.; Elkana, Y.; Pleskovic, B.), s. 301-316 ISBN 978-0-8213-6595-3. [Scaling Up Capacity Building in Economics Education and Research: Lessons Learned and Future Directions. Budapest (HU), 14.06.2005-15.06.2005] Institutional research plan: CEZ:AV0Z70850503 Keywords : economics education * economics research * CERGE-EI * PhD program Subject RIV: AH - Economics

  6. Pathways to the PhD in Nursing: An Analysis of Similarities and Differences.

    Science.gov (United States)

    Nehls, Nadine; Barber, Gale; Rice, Elizabeth

    2016-01-01

    New educational pathways are needed to increase the number of doctor of philosophy (PhD)-prepared nurses. To address this need, an early-entry PhD option designed to engage students in PhD coursework and research during the undergraduate nursing major was developed at the University of Wisconsin-Madison. An evaluation comparing the early-entry option with two more conventional entry points was conducted. Three groups (N = 84) comprised the sample: (a) early-entry students admitted as undergraduates or immediately upon graduation (N = 29), (b) mid-entry students with baccalaureate degrees and at least 1 year of work experience (N = 27), and (c) delayed-entry students with master's degrees and 1 or more years of work experience (N = 28). Qualitative and quantitative data were collected from the 3 groups of students who were admitted from 2002 to 2011. The sources of data were transcriptions of individual interviews and reviews of existing data. Seventy-seven percent of the sample participated in the individual interviews. The database review included all students who matriculated into the PhD program. Common themes among the 3 groups included a need for educational funding, the importance of a faculty mentor, and concern about preparation for the teaching role and the academic work environment. The groups were also comparable in terms of research productivity during doctoral study and postgraduation employment. Differences were found on measures of diversity, program progression, and perceptions of clinical competence. The findings provide needed data for the development and expansion of educational pathways to the PhD in nursing. PMID:27216124

  7. Education Blues : A Study of the Emotional Roller Coaster Rideof Ph.D. Education

    OpenAIRE

    Berggren, Uffe

    2012-01-01

    The study makes use of theories of emotions to describe and analyze interviewsconducted with eight students who had recently taken part in, or were at the moment,taking part in a doctoral education at the Faculties of Humanities or Social Science atStockholm University. This study is thus a qualitative study focusing on the followingresearch questions: Firstly, how does the Ph.D education influence the studentemotionally. Secondly: do the participants in the doctoral education experienceemoti...

  8. A call for performance-based data in the study of STEM Ph.D. education

    OpenAIRE

    David F. Feldon; Maher, Michelle A.; Timmerman, Briana E.

    2010-01-01

    Understanding the scholarly development of Ph.D. students in science, technology, engineering, and mathematics (STEM) is vital to the preparation of the scientific workforce. During doctoral study, students learn to be professional scientists and acquire the competencies to succeed in those roles. However, this complex process is not well studied. Research to date suffers from overreliance on a narrow range of methods that cannot provide data appropriate for addressing questions of causality ...

  9. Robert Lončarić, PhD in Geography

    Directory of Open Access Journals (Sweden)

    Damir Magaš

    2010-12-01

    Full Text Available On June 29, 2010, Robert Lončarić defended his PhD thesis Littoralisation of the Kvarner Islands – a Hydrogeographical Basis at the Department of Geography of the University of Zadar. Members of the Defence Committee  were Prof. Dr. Damir Magaš (mentor, Assoc. Prof. Dr. Martin Glamuzina, (Chairman and Prof. Dr. Ognjen Bonacci of the Faculty of Civil Engineering and Architecture in Split.

  10. Dražen Tutić, PhD in Technical Sciences

    Directory of Open Access Journals (Sweden)

    Miljenko Lapaine

    2009-12-01

    Full Text Available Dražen Tutić defended his PhD thesis Stereographic and Other Conformal Map Projections  for Croatia at the Faculty of Geodesy of the University of Zagreb on August 4, 2009. The thesis was evaluated by the Committee: Prof. Emeritus Nedjeljko Frančula, Prof. Dr. Miljenko Lapaine (mentor and Prof. Dr. Dušan Petrovič from the Faculty of Civil and Geodetic Engineering of the University of Ljubljana.

  11. Analysis of information use in agricultural science PhD theses at Central University of Venezuela

    OpenAIRE

    Haparro-Martinez, Exio Isaac; Marzal, Miguel Ángel

    2008-01-01

    Purpose – To analyze information use in agricultural science PhD theses submitted between 1986 and 2002 in the Faculty of Agronomy, Central University of Venezuela (UCV). Design/methodology/approach – The source of information was the UCV Faculty of Agronomy, Library's database, “Tesis”. The unidimensional production and use indicators analyzed included: scientific production, reference density, self-citations, document contemporaneousness and type of documents cited, reference scatterin...

  12. Brown-York energy and radial geodesics

    Energy Technology Data Exchange (ETDEWEB)

    Blau, Matthias; Rollier, Blaise [Institut de Physique, Universite de Neuchatel Rue Breguet 1, CH-2000 Neuchatel (Switzerland)

    2008-05-21

    We compare the Brown-York (BY) and the standard Misner-Sharp (MS) quasilocal energies for round spheres in spherically symmetric spacetimes from the point of view of radial geodesics. In particular, we show that the relation between the BY and MS energies is precisely analogous to that between the (relativistic) energy E of a geodesic and the effective (Newtonian) energy E{sub eff} appearing in the geodesic equation, thus shedding some light on the relation between the two. Moreover, for Schwarzschild-like metrics we establish a general relationship between the BY energy and the geodesic effective potential which explains and generalizes the recently observed connection between negative BY energy and the repulsive behaviour of geodesics in the Reissner-Nordstroem metric. We also comment on the extension of this connection between geodesics and the quasilocal BY energy to regions inside a horizon.

  13. Poisoning with brown fly agaric, Amanita regalis.

    Science.gov (United States)

    Elonen, E; Tarssanen, L; Härkönen, M

    1979-01-01

    Three patients ate different amounts of a common northern mushroom, brown fly agaric, Amanita regalis. All of them believed they had eaten delicious parasol mushrooms, Macrolepiota procera. The symptoms of poisoning began 1--2 hours after ingestion of the mushrooms. All the patients had marked gastrointestinal symptoms: nausea and heavy vomiting. Two had central nervous system manifestations and cholinergic symptoms: hallucinations, confusion, or loss of consciousness as well as copious salivation, or sweating. All patients recovered within 4--24 hours without any damage to liver, kidneys or central nervous system. It seems that cooking the mushrooms does not completely neutralize the toxic agents of Amanita regalis. The analysis of fried mushrooms shows that it may be possible to identify mushrooms reliably from the remains of a meal. PMID:760400

  14. What John Browne actually said at Stanford

    International Nuclear Information System (INIS)

    In May 1997, the Chief Executive of BP, John Browne, delivered a speech on global climate change at Stanford University, California. A shortened version of the speech is presented. BP have accepted the possibility of a link between greenhouse gas emissions and climate change and are basing their policies on that acceptance. The company is committed to a step-by-step process, involving both action to develop solutions and continuing research to improve knowledge, that will balance the requirements of economic development and environmental protection. Five specific steps are outlined. These are: the monitoring and controlling of carbon dioxide emissions in all aspects of the company's operations increasing the level of support given to continuing scientific work on climate change; technology transfer and joint implementation with other parties to limit and reduce net emission levels; the development of alternative energy sources, in particular, solar power; contributing to the public policy debate in search of wider global answers to the problem. (Author)

  15. Atmospheric Brown Clouds- from science towards policy

    Science.gov (United States)

    Sherestha, S.; Iyngararasan, M.

    2010-12-01

    Atmospheric Brown Clouds (ABCs) and its interaction with climate change is an emerging environmental issue. Studies demonstrate that ABCs and its interaction with build-up of greenhouse gases significantly affect the regional climate, glacial melting, hydrological cycle, agriculture and public health. For the next decades, the regional aerosol effects will continue to play a major role in environmental management as long as current strong sources of air pollution remain. An integrated multi-pollutant multi-sectoral approach for addressing atmospheric issues will result in optimum environmental and socioeconomic benefits. Regional intergovernmental networks have been established to address air pollution issues in different parts of the globe. These intergovernmental networks could be empowered to promote integrated approach for addressing the atmospheric environmental issues.

  16. Brown Grease to Biodiesel Demonstration Project Report

    Energy Technology Data Exchange (ETDEWEB)

    San Francisco Public Utilities Commission; URS Corporation; Biofuels, Blackgold; Carollo Engineers

    2013-01-30

    program by other municipal agencies (as applicable). In order to accomplish the goals of the project, the following steps were performed: 1. Operation of a demonstration facility designed to receive 10,000 to 12,000 gallons of raw Trap Waste each day from private Trap Waste hauling companies. The demonstration facility was designed and built by Pacific Biodiesel Technologies (PBTech). The demonstration facility would also recover 300 gallons of Brown Grease per day from the raw Trap Waste. The recovered Brown Grease was expected to contain no more than 2% Moisture, Insolubles, and Unsaponifiables (MIU) combined. 2. Co-digestion of the side streams (generated during the recovery of 300 gallons of Brown Grease from the raw Trap Waste) with wastewater sludge in the WWTP's anaerobic digesters. The effects of the side streams on anaerobic digestion were quantified by comparison with baseline data. 3. Production of 240 gallons per day of ASTM D6751-S15 grade Biodiesel fuel via a Biodiesel conversion demonstration facility, with the use of recovered Brown Grease as a feedstock. The demonstration facility was designed and built by Blackgold Biofuels (BGB). Side streams from this process were also co-digested with wastewater sludge. Bench-scale anaerobic digestion testing was conducted on side streams from both demonstration facilities to determine potential toxicity and/or changes in biogas production in the WWTP anaerobic digester. While there is a lot of theoretical data available on the lab-scale production of Biodiesel from grease Trap Waste, this full-scale demonstration project was one of the first of its kind in the United States. The project's environmental impacts were expected to include: Reduction of greenhouse gas emissions by prevention of the release of methane at landfills. Although the combustion product of Biodiesel and Methane gas produced in the Anaerobic digester, Carbon Dioxide, is also a greenhouse gas; it is 20 times weaker for the same amount

  17. Correlated spectral variability in brown dwarfs

    CERN Document Server

    Bailer-Jones, C A L

    2007-01-01

    Models of brown dwarf atmospheres suggest they exhibit complex physical behaviour. Observations have shown that they are indeed dynamic, displaying small photometric variations over timescales of hours. Here I report results of infrared (0.95-1.64 micron) spectrophotometric monitoring of four field L and T dwarfs spanning timescales of 0.1-5.5 hrs, the goal being to learn more about the physical nature of this variability. Spectra are analysed differentially with respect to a simultaneously observed reference source in order to remove Earth-atmospheric variations. The variability amplitude detected is typically 2-10%, depending on the source and wavelength. I analyse the data for correlated variations between spectral indices. This approach is more robust than single band or chisq analyses, because it does not assume an amplitude for the (often uncertain) noise level (although the significance test still assumes a shape for the noise power spectrum). Three of the four targets show significant evidence for cor...

  18. Management of Stress and Anxiety Among PhD Students During Thesis Writing: A Qualitative Study.

    Science.gov (United States)

    Bazrafkan, Leila; Shokrpour, Nasrin; Yousefi, Alireza; Yamani, Nikoo

    2016-01-01

    Today, postgraduate students experience a variety of stresses and anxiety in different situations of academic cycle. Stress and anxiety have been defined as a syndrome shown by emotional exhaustion and reduced personal goal achievement. This article addresses the causes and different strategies of coping with this phenomena by PhD students at Iranian Universities of Medical Sciences. The study was conducted by a qualitative method using conventional content analysis approach. Through purposive sampling, 16 postgraduate medical sciences PhD students were selected on the basis of theoretical sampling. Data were gathered through semistructured interviews and field observations. Six hundred fifty-four initial codes were summarized and classified into 4 main categories and 11 subcategories on the thematic coding stage dependent on conceptual similarities and differences. The obtained codes were categorized under 4 themes including "thesis as a major source of stress," "supervisor relationship," "socioeconomic problem," and "coping with stress and anxiety." It was concluded that PhD students experience stress and anxiety from a variety of sources and apply different methods of coping in effective and ineffective ways. Purposeful supervision and guidance can reduce the cause of stress and anxiety; in addition, coping strategy must be in a thoughtful approach, as recommended in this study. PMID:27455365

  19. Educating future nursing scientists: Recommendations for integrating omics content in PhD programs.

    Science.gov (United States)

    Conley, Yvette P; Heitkemper, Margaret; McCarthy, Donna; Anderson, Cindy M; Corwin, Elizabeth J; Daack-Hirsch, Sandra; Dorsey, Susan G; Gregory, Katherine E; Groer, Maureen W; Henly, Susan J; Landers, Timothy; Lyon, Debra E; Taylor, Jacquelyn Y; Voss, Joachim

    2015-01-01

    Preparing the next generation of nursing scientists to conduct high-impact, competitive, sustainable, innovative, and interdisciplinary programs of research requires that the curricula for PhD programs keep pace with emerging areas of knowledge and health care/biomedical science. A field of inquiry that holds great potential to influence our understanding of the underlying biology and mechanisms of health and disease is omics. For the purpose of this article, omics refers to genomics, transcriptomics, proteomics, epigenomics, exposomics, microbiomics, and metabolomics. Traditionally, most PhD programs in schools of nursing do not incorporate this content into their core curricula. As part of the Council for the Advancement of Nursing Science's Idea Festival for Nursing Science Education, a work group charged with addressing omics preparation for the next generation of nursing scientists was convened. The purpose of this article is to describe key findings and recommendations from the work group that unanimously and enthusiastically support the incorporation of omics content into the curricula of PhD programs in nursing. The work group also calls to action faculty in schools of nursing to develop strategies to enable students needing immersion in omics science and methods to execute their research goals. PMID:26123776

  20. Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways

    Directory of Open Access Journals (Sweden)

    Javier Rodriguez

    2016-03-01

    Full Text Available Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate- (2OG dependent enzymes and, although the biochemistry is well understood, until now only a few substrates have been described for these enzymes. Using quantitative interaction proteomics, we screened for substrates of the proline hydroxylase PHD3 and the asparagine hydroxylase FIH, which regulate the HIF-mediated hypoxic response. We were able to identify hundreds of potential substrates. Enrichment analysis revealed that the potential substrates of both hydroxylases cluster in the same pathways but frequently modify different nodes of signaling networks. We confirm that two proteins identified in our screen, MAPK6 (Erk3 and RIPK4, are indeed hydroxylated in a FIH- or PHD3-dependent mechanism. We further determined that FIH-dependent hydroxylation regulates RIPK4-dependent Wnt signaling, and that PHD3-dependent hydroxylation of MAPK6 protects the protein from proteasomal degradation.

  1. "PhD Comics" author Jorge Cham on the power of procrastination

    CERN Multimedia

    Stefania Pandolfi

    2015-01-01

    From Tuesday, 22 to Friday, 25 September, Jorge Cham visited CERN. The PHD Movie 2 was screened in the Main Auditorium  and the cartoonist also took part in one of the Researchers' Night events.    Jorge Cham in the CERN Control Centre. On the first day, the author of the comic strip Piled Higher and Deeper (PhD Comics) visited the CERN Control Centre, the Synchrocyclotron, the CMS Service Cavern and the ATLAS control room. On Thursday, he had a busy afternoon, starting with signing copies of his books and then giving a talk entitled “The Power of Procrastination” in a packed Main Auditorium. He made the audience laugh by narrating his experience as a graduate student in robotics at Stanford University, recounting how he started drawing PhD Comics and how it rapidly became popular in universities all over the world. He then analysed the frustrations and anxieties commonly experienced by any graduate student, causing...

  2. MS PHD'S: A successful model for reaching underrepresented minorities (URM) students through virtual platforms

    Science.gov (United States)

    Scott, O.; Johnson, A.; Williamson, V.; Ricciardi, L.; Jearld, A., Jr.; Guzman, W. I.

    2014-12-01

    To successfully recruit and retain underrepresented minority (URM) students and early career scientists, many programs supplement traditional curricular activities with multiple online platforms, establishing "virtual communities" that are free and easily accessible. These virtual communities offer readily sustainable opportunities to facilitate communication across a wide range of cultural lines and socioeconomic levels thereby broadening participation and inclusivity in STEM. Established in 2003, the Minorities Striving and Pursuing Higher Degrees of Success (MS PHD'S) in Earth System Science Professional Development Program has successfully used virtual community tools such as a listserv, community forum, social media, and VoIP technologies, to extend the face-to-face activities of the program and support the advancement of URM students and early career scientists in STEM. The use of multiple facets of virtual community by MS PHD'S participants supports and encourages "real life" interactions and mentorship, facilitates networking and professional development, and maintains continuity of shared networks. The program is now in its ninth cohort and supports 213 participants. To date, 54 participants have completed their PhD and another 61 are currently enrolled in doctoral programs.

  3. Chemical Decontamination at Browns Ferry Unit 1

    International Nuclear Information System (INIS)

    In May, 2002, the Tennessee Valley Authority's (TVA) Board of Directors approved the recovery and restart of Unit 1 at Browns Ferry Nuclear Station. As an initial step in the site characterization and restart feasibility review, a majority of the primary reactor circuit was chemically decontaminated. Close cooperation between TVA and vendor personnel resulted in project completion ahead of schedule with outstanding results. The final average decontamination factors were excellent, and the final dose rates were very low, with contact readings on most points between one and three mRem/hr. In addition to allowing TVA to do a complete and thorough job of determining the feasibility of the Unit 1 restart, the decontamination effort will greatly reduce personnel exposure during plant recovery, both whole body exposure to gamma radiation and airborne exposure during pipe replacement efforts. The implementation of lessons learned from previous decontamination work performed at Browns Ferry, as well as decontamination efforts at other plants aided greatly in the success. Specific items of note are: (1) The initial leak check of the temporary decontamination system should include ancillary systems such as the spent resin system, as well as the main circulation loop. This could save time and dose exposure if leaks are discovered before the use of such systems is required. (2) Due to the quick turnaround time from the award of contract, a vendor representative was onsite early in the project to help with engineering efforts and procedures. This aided greatly in completing preparations for the decontamination. (3) The work was performed under a single maintenance activity. This resulted in great craft and plant support. (4) The constant coverage by the site's decontamination flush directors provided timely plant support and interface. (5) The FPC system isolation and back flushing to prevent residual chemicals from being left in the FPC system should have been addressed in more

  4. 78 FR 32556 - Safety Zone; 2013 Ocean City Air Show, Atlantic Ocean; Ocean City, MD

    Science.gov (United States)

    2013-05-31

    ... FR Federal Register NPRM Notice of Proposed Rulemaking A. Regulatory History and Information The... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; 2013 Ocean City Air Show, Atlantic Ocean; Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard...

  5. 76 FR 60873 - Jeffery M. Freesemann, M.D.; Decision and Order

    Science.gov (United States)

    2011-09-30

    ... changes in her ] that he found more ``attractive,'' such as how she was more prone to stay up late and... will not engage in future misconduct. Cf. Ronald Lynch, M.D., 75 FR 78745, 78749 (2010). Order Pursuant.... 52. Galvan told her that around noon he would pick up ``paperwork'' (a term that Det. Boyd...

  6. 75 FR 26993 - Alvin Darby, M.D.; Denial of Application

    Science.gov (United States)

    2010-05-13

    ... dependency on crack cocaine and `primo,' a mixture of cocaine and marijuana smoked together.'' GX 3, at 2... factors are * * * considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). I... application under section 303. See The Lawsons, Inc., 72 FR 74334, 74337 (2007); Anthony D. Funches, 64...

  7. 76 FR 31235 - Safety Zone; Ocean City Air Show, Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2011-05-31

    ... Ocean City, Maryland. (b) Definition: For purposes of enforcement of this section, Captain of the Port... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ocean City Air Show, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Temporary Final rule. SUMMARY: The Coast Guard...

  8. Functional identification of MdSIZ1 as a SUMO E3 ligase in apple.

    Science.gov (United States)

    Zhang, Rui-Fen; Guo, Ying; Li, Yuan-Yuan; Zhou, Li-Jie; Hao, Yu-Jin; You, Chun-Xiang

    2016-07-01

    SUMOylation, the conjugation of target proteins with SUMO (small ubiquitin-related modifier), is a type of post-translational modification in eukaryotes and involves the sequential action of activation (E1), conjugation (E2) and ligation (E3) enzymes. In Arabidopsis, the AtSIZ1 protein is a SUMO E3 ligase that promotes the conjugation of SUMO proteins to target substrates. Here, we isolated and identified a SUMO E3 ligase, MdSIZ1, in apple, which was similar to AtSIZ1. SUMOylation analysis showed that MdSIZ1 had SUMO E3 ligase activity in vitro and in vivo. SUMO conjugation was increased by high temperatures, low temperatures, and abscisic acid (ABA). The ectopic expression of MdSIZ1 in Arabidopsis siz1-2 mutant plants partially complemented the morphological mutant phenotype and enhanced the levels of SUMO conjugation. Taken together, these results suggest that MdSIZ1-mediated SUMO conjugation of target proteins is an important process that regulates the adaptation of apple plants to various environmental stresses. PMID:27152458

  9. 77 FR 3185 - Proposed Establishment of Class E Airspace; Grasonville, MD

    Science.gov (United States)

    2012-01-23

    ... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of..., 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The incorporation by... Grasonville, MD, providing the controlled airspace required to support the Copter RNAV GPS special...

  10. 77 FR 22523 - Safety Zone; 2012 Ocean City Air Show; Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2012-04-16

    ... Federal Register (73 FR 3316). ] Public Meeting We do not now plan to hold a public meeting. But you may... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; 2012 Ocean City Air Show; Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast...

  11. 78 FR 76322 - Thomas Neuschatz, M.D.; Decision and Order

    Science.gov (United States)

    2013-12-17

    ... of J.G.'s known addiction, ``but inaccurately represented this as a treatment for a chronic pain... her chronic pain rather than as treatment for her opioid addiction was patently false.'' Id. at 18...(f). ``These factors are . . . considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR...

  12. 77 FR 45675 - Margy Temponeras, M.D.; Decision and Order

    Science.gov (United States)

    2012-08-01

    ... that Mrs. Leadingham similarly stated that ``she was there to dispense the medication and put the... medication to patients.'' (Id.) The location was described as having the doctor's office on the left of the... encompasses the factors listed in Section 824(a).'' ALJ at 19 n.24 (citing Kuen H. Chen, M.D., 58 FR...

  13. Novel plasmid conferring kanamycin and tetracycline resistance in turkey-derived Campylobacter jejuni strain 11601MD

    Science.gov (United States)

    In Campylobacter spp., resistance to the antibiotics kanamycin and tetracycline is frequently associated with plasmid-borne genes. However, relatively few plasmids of Campylobacter jejuni have been fully characterized to date. A novel plasmid (p11601MD; 44,095 bp.) harboring tet(O) was identified in...

  14. 76 FR 65118 - Drawbridge Operation Regulation; Bear Creek, Sparrows Point, MD

    Science.gov (United States)

    2011-10-20

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Sparrows... Avenue) highway toll drawbridge across Bear Creek, mile 1.5, Sparrows Point, MD was replaced with a fixed... Bear Creek, mile 1.5 was removed and replaced with a fixed bridge in 1998. Prior to 1998, a...

  15. 77 FR 23599 - Special Local Regulations for Marine Events; Potomac River, Charles County, MD

    Science.gov (United States)

    2012-04-20

    ... regulations to the Small Business and Agriculture Regulatory Enforcement Ombudsman and the Regional Small...; Potomac River, Charles County, MD'' in the Federal Register (77 FR 27). We received one comment on the... substantial number of small entities. The term ``small entities'' comprises small businesses,...

  16. Draft Genome Sequence of Lactobacillus jensenii Strain MD IIE-70(2)

    OpenAIRE

    Karlyshev, Andrey V.; Nadarajah, Sindhujan; Abramov, Vyacheslav M.

    2013-01-01

    A draft genome sequence of Lactobacillus jensenii strain MD IIE-70(2) was determined using Ion PGM technology. The reads were mapped to a reference strain and assembled using a combination of tools. The genetic features revealed in this study will assist in understanding the probiotic properties of Lactobacillus bacteria.

  17. Draft Genome Sequence of Lactobacillus jensenii Strain MD IIE-70(2).

    OpenAIRE

    Karlyshev, Andrey V.; Nadarajah, Sindhujan; Abramov, Vyacheslav M.

    2013-01-01

    A draft genome sequence of Lactobacillus jensenii strain MD IIE-70(2) was determined using Ion PGM technology. The reads were mapped to a reference strain and assembled using a combination of tools. The genetic features revealed in this study will assist in understanding the probiotic properties of Lactobacillus bacteria.

  18. 78 FR 76169 - Patuxent Research Refuge, Prince George's and Anne Arundel Counties, MD; Final Comprehensive...

    Science.gov (United States)

    2013-12-16

    .... Geological Survey (USGS) Patuxent Wildlife Research Center, a leading international research institute for... Fish and Wildlife Service Patuxent Research Refuge, Prince George's and Anne Arundel Counties, MD... significant impact (FONSI) for Patuxent Research Refuge (Patuxent RR, refuge), located in Prince George's...

  19. 75 FR 18778 - Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2010-04-13

    ... public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). Public Meeting We do... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast...

  20. Heat Flow Data Cruise MD72 RV Marion Dufresne over the Mascarene Ridge

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data were gathered by the R/V Marion Dufresne in May and June of 1992 over the Mascarene Ridge in the Indian Ocean on cruise MD72/MASCAFLUX. Heat flow measurements...

  1. Electrochemical endotoxin sensors based on TLR4/MD-2 complexes immobilized on gold electrodes.

    Science.gov (United States)

    Yeo, Tae Yun; Choi, Ji Suk; Lee, Byung Kook; Kim, Beob Soo; Yoon, Hwa In; Lee, Hyeong Yun; Cho, Yong Woo

    2011-10-15

    Even low concentrations of endotoxins can be life-threatening. As such, continuous effort has been directed toward the development of sensitive and specific endotoxin detection systems. In this paper, we report the design and fabrication of a new electrochemical endotoxin sensor based on a human recombinant toll-like receptor 4 (rhTLR4) and myeloid differentiation-2 (MD-2) complex. The rhTLR4/MD-2 complex, which specifically binds to endotoxin, was immobilized on gold electrodes through a self-assembled monolayer (SAM) technique involving the use of dithiobis(succinimidyl undecanoate) (DSU). The surface topography of the electrodes at each fabrication stage was characterized with a nanosurface profiler and atomic force microscope (AFM). The electrochemical signals generated from interactions between the rhTLR4/MD-2 complex and the endotoxin were characterized by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). A linear relationship between the peak current and endotoxin concentration was obtained in the range of 0.0005 to 5 EU/mL with a correlation coefficient (R(2)) of 0.978. The estimated limit of detection (LOD) was fairly low, 0.0002 EU/mL. The rhTLR4/MD-2 based sensors exhibited no current responses to dipalmitoylphosphatidylcholine (DPPC) bearing two lipid chains, which is structurally similar to endotoxin, indicating the high specificity of the sensors to endotoxin. PMID:21816600

  2. 75 FR 41789 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

    Science.gov (United States)

    2010-07-19

    ... public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). Public Meeting We do... for Marine Events; Patuxent River, Solomons, MD'' in the Federal Register (75 FR 111). The NPRM stated... Solomon's Pier. A large spectator fleet is expected during the event. Due to the need for vessel...

  3. Lonely and hardworking : international PhD candidates cross-cultural adjustment at the University of Oslo

    OpenAIRE

    2010-01-01

    In recent years, the number of scholars that expatriate has increased, and with this also the number of scholars having to adjust to a new cultural environment. PhD candidates constitute an important part of this growth; yet, their cross-cultural experiences have not been studied accordingly. Hence, this study examines how international PhD candidates at the University of Oslo (UiO) characterize their experiences when adjusting to a new cultural environment. Furthermore, the study is also aim...

  4. The Need for Greater Support in Academic Writing for PhD Students in Mathematics and Related Subjects

    OpenAIRE

    Silvers, L. J.

    2014-01-01

    Within the United Kingdom (UK), the graduate student population in mathematics departments seeking to obtain the higher degree of Doctor of Philosophy (PhD) has become increasingly diverse as a result of a number of factors. This student body faces a variety of challenges that raise questions about what provisions universities should provide in order to give these students the greatest chance of a successful completion of their PhD programme. In this article I argue that universities shou...

  5. Identification of key residues that confer Rhodobacter sphaeroides LPS activity at horse TLR4/MD-2.

    Directory of Open Access Journals (Sweden)

    Katherine L Irvine

    Full Text Available The molecular determinants underpinning how hexaacylated lipid A and tetraacylated precursor lipid IVa activate Toll-like receptor 4 (TLR4 are well understood, but how activation is induced by other lipid A species is less clear. Species specificity studies have clarified how TLR4/MD-2 recognises different lipid A structures, for example tetraacylated lipid IVa requires direct electrostatic interactions for agonism. In this study, we examine how pentaacylated lipopolysaccharide from Rhodobacter sphaeroides (RSLPS antagonises human TLR4/MD-2 and activates the horse receptor complex using a computational approach and cross-species mutagenesis. At a functional level, we show that RSLPS is a partial agonist at horse TLR4/MD-2 with greater efficacy than lipid IVa. These data suggest the importance of the additional acyl chain in RSLPS signalling. Based on docking analysis, we propose a model for positioning of the RSLPS lipid A moiety (RSLA within the MD-2 cavity at the TLR4 dimer interface, which allows activity at the horse receptor complex. As for lipid IVa, RSLPS agonism requires species-specific contacts with MD-2 and TLR4, but the R2 chain of RSLA protrudes from the MD-2 pocket to contact the TLR4 dimer in the vicinity of proline 442. Our model explains why RSLPS is only partially dependent on horse TLR4 residue R385, unlike lipid IVa. Mutagenesis of proline 442 into a serine residue, as found in human TLR4, uncovers the importance of this site in RSLPS signalling; horse TLR4 R385G/P442S double mutation completely abolishes RSLPS activity without its counterpart, human TLR4 G384R/S441P, being able to restore it. Our data highlight the importance of subtle changes in ligand positioning, and suggest that TLR4 and MD-2 residues that may not participate directly in ligand binding can determine the signalling outcome of a given ligand. This indicates a cooperative binding mechanism within the receptor complex, which is becoming increasingly

  6. Cultivar affects browning susceptibility of freshly cut star fruit slices

    Directory of Open Access Journals (Sweden)

    Teixeira Gustavo Henrique de Almeida

    2006-01-01

    Full Text Available Consumption of freshly-cut horticultural products has increased in the last few years. The principal restraint to using freshly-cut carambola is its susceptibility to tissue-browning, due to polyphenol oxidase-mediated oxidation of phenolic compounds present in the tissue. The current study investigated the susceptibility to browning of star fruit slices (Averrhoa carambola L. of seven genotypes (Hart, Golden Star, Taen-ma, Nota-10, Malásia, Arkin, and Fwang Tung. Cultivar susceptibility to browning as measured by luminosity (L* varied significantly among genotypes. Without catechol 0.05 M, little changes occurred on cut surface of any cultivars during 6 hour at 25degreesC, 67% RH. Addition of catechol led to rapid browning, which was more intense in cvs. Taen-ma, Fwang Tung, and Golden Star, with reduction in L* value of 28.60%, 27.68%, and 23.29%, respectively. Browning was more intense in the center of the slices, particularly when treated with catechol, indicating highest polyphenol oxidase (PPO concentration. Epidermal browning, even in absence of catechol, is a limitation to visual acceptability and indicates a necessity for its control during carambola processing. Care must be given to appropriate selection of cultivars for fresh-cut processing, since cultivar varied in browning susceptibility in the presence of catechol.

  7. Seasonal movement of brown trout in a southern appalachian river

    Science.gov (United States)

    Burrell, K.H.; Isely, J.J.; Bunnell, D.B., Jr.; Van Lear, D. H.; Dolloff, C.A.

    2000-01-01

    Radio telemetry was used to evaluate the seasonal movement, activity level, and home range size of adult brown trout Salmo trutta in the Chattooga River watershed, one of the southernmost coldwater stream systems in the United States. In all, 27 adult brown trout (262-452 mm total length) were successfully monitored from 16 November 1995 to 15 December 1996. During the day, adult brown trout were consistently found in small, well-established home ranges of less than 270 m in stream length. However, 8 of a possible 18 study fish made spawning migrations during a 2-week period in November 1996. The daytime locations of individual fish were restricted to a single pool or riffle-pool combination, and fish were routinely found in the same location over multiple sampling periods. Maximum upstream movement during spawning was 7.65 km, indicating that brown trout in the Chattooga River have the ability to move long distances. Spawning brown trout returned to their prespawning locations within a few days after spawning. Brown trout maintained larger home ranges in winter than in other seasons. When spawning-related movement was deleted from the analysis, brown trout moved more on a weekly basis in fall than in summer. Brown trout were more active in fall and winter than in spring and summer. Apart from spawning migrations, displacement from established home ranges was not observed for any fish in the study. Although summer water temperatures reached and exceeded reported upper thermal-preference levels, brown trout did not move to thermal refuge areas in nearby tributaries during the stressful summer periods.

  8. 基于C#技术的MD5加密算法设计与实现%Design and Implementation of MD5 Algorithm Based on C# Technology

    Institute of Scientific and Technical Information of China (English)

    王倩丽

    2010-01-01

    本文对Message-Digest Algorithm 5(信息-摘要算法)进行了简要描述,并对MD5算法的原理进行了深入分析.同时采用目前流行的C#语言对MD5算法进行了具体的应用,实现了MD5加密演示系统.虽然MD5算法因王小云教授在2004国际密码学会议上发表的论文引起了很大的反响,但MD5算法仍然在数字签名、电子商务、信息加密等领域中有着非常广泛的应用.

  9. MD5 Encryption Algorithm and its Application in NETPRO Protocol%MD5加密算法及其在NETPRO协议中的应用

    Institute of Scientific and Technical Information of China (English)

    王大志; 马良

    2005-01-01

    短信网关系统中,内容提供商与网关之间通信采用客户机/服务器(C/S)模式,网关通过NETPRO协议与内容提供商通信.网络安全问题变得非常突出,对于用户密码等敏感信息,应该有一种能有效防止被轻易截获的方法来保护.MD5加密算法就是这种设想的强有力的工具.

  10. Brown Tumors: A Case Report and Review of the Literature

    Science.gov (United States)

    Can, Özgür; Boynueğri, Başak; Gökçe, Ali Murat; Özdemir, Ebru; Ferhatoğlu, Ferhat; Canbakan, Mustafa; Şahin, Gülizar Manga; Titiz, Mesut İzzet; Apaydın, Süheyla

    2016-01-01

    Brown tumors are focal bone lesions, encountered in patients with uncontrolled hyperparathyroidism. They can be located in any part of the skeleton. Clinically significant lesions in the craniofacial bones are rare. Craniofacial involvement may cause facial disfiguration and compromise social ease of the patient and normal functions, such as chewing, talking, and breathing. In this case report, we present a patient with a brown tumor of the craniofacial bones provoked by secondary hyperparathyroidism and review the last 10 years of craniofacial brown tumors associated with secondary hyperparathyroidism in the English literature. PMID:27066494

  11. Registration of the Soft Red Winter Wheat Germplasm MD01W233-06-1 Resistant to Fusarium Head Blight

    Science.gov (United States)

    MD01W233-06-1 (Reg. No., PI ) is a soft red winter wheat (SRWW) (Triticum aestivum L.) germplasm line developed at the University of Maryland and released by the Maryland Agricultural Experiment Station in 2009. MD01W233-06-1 was selected from a cross of ‘McCormick’/ ‘Choptank’ made in 2001. McCorm...

  12. 77 FR 9228 - AP Gas & Electric (MD), LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Science.gov (United States)

    2012-02-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission AP Gas & Electric (MD), LLC; Supplemental Notice That Initial Market-Based... above-referenced proceeding of AP Gas & Electric (MD), LLC's application for market-based rate...

  13. Draft Genome Sequence of Ralstonia sp. MD27, a Poly(3-Hydroxybutyrate)-Degrading Bacterium, Isolated from Compost

    OpenAIRE

    Zhu, Morgan; McCully, Lucy M.; Silby, Mark W; Charles-Ogan, Tamunonengiyeofori I.; Huang, Jean; Brigham, Christopher J.

    2015-01-01

    Ralstonia sp. strain MD27, a novel biopolymer-degrading betaproteobacterium, was isolated from compost samples. This organism has been shown to utilize the biopolymer poly(3-hydroxybutyrate) [P(3HB)] as a carbon source for growth. We report the draft genome sequence of MD27 with an estimated total sequence length of 5.9 Mb.

  14. 33 CFR 165.556 - Regulated Navigation Area; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD.

    Science.gov (United States)

    2010-07-01

    ... areas, found in 33 CFR 165.13, apply to the regulated navigation area described in paragraph (a) of this...; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD. 165.556 Section 165.556 Navigation and..., Chesapeake City Anchorage Basin, MD. (a) Location. The following area is a regulated navigation area:...

  15. Browning boreal forests of western North America

    Science.gov (United States)

    Verbyla, David

    2011-12-01

    The GIMMS NDVI dataset has been widely used to document a 'browning trend' in North American boreal forests (Goetz et al 2005, Bunn et al 2007, Beck and Goetz 2011). However, there has been speculation (Alcaraz-Segura et al 2010) that this trend may be an artifact due to processing algorithms rather than an actual decline in vegetation activity. This conclusion was based primarily on the fact that GIMMS NDVI did not capture NDVI recovery within most burned areas in boreal Canada, while another dataset consistently showed post-fire increasing NDVI. I believe that the results of Alcaraz-Segura et al (2010) were due simply to different pixel sizes of the two datasets (64 km2 versus 1 km2 pixels). Similar results have been obtained from tundra areas greening in Alaska, with the results simply due to these pixel size differences (Stow et al 2007). Furthermore, recent studies have documented boreal browning trends based on NDVI from other sensors. Beck and Goetz (2011) have shown the boreal browning trend derived from a different sensor (MODIS) to be very similar to the boreal browning trend derived from the GIMMS NDVI dataset for the circumpolar boreal region. Parent and Verbyla (2010) found similar declining NDVI patterns based on NDVI from Landsat sensors and GIMMS NDVI in boreal Alaska. Zhang et al (2008) found a similar 'browning trend' in boreal North America based on a production efficiency model using an integrated AVHRR and MODIS dataset. The declining NDVI trend in areas of boreal North America is consistent with tree-ring studies (D'Arrigo et al 2004, McGuire et al 2010, Beck et al 2011). The decline in tree growth may be due to temperature-induced drought stress (Barber et al 2000) caused by higher evaporative demands in a warming climate (Lloyd and Fastie 2002). In a circumpolar boreal study, Lloyd and Bunn (2007) found that a negative relationship between temperature and tree-ring growth occurred more frequently in warmer parts of species' ranges

  16. Discovery of Nearest Known Brown Dwarf

    Science.gov (United States)

    2003-01-01

    Bright Southern Star Epsilon Indi Has Cool, Substellar Companion [1] Summary A team of European astronomers [2] has discovered a Brown Dwarf object (a 'failed' star) less than 12 light-years from the Sun. It is the nearest yet known. Now designated Epsilon Indi B, it is a companion to a well-known bright star in the southern sky, Epsilon Indi (now "Epsilon Indi A"), previously thought to be single. The binary system is one of the twenty nearest stellar systems to the Sun. The brown dwarf was discovered from the comparatively rapid motion across the sky which it shares with its brighter companion : the pair move a full lunar diameter in less than 400 years. It was first identified using digitised archival photographic plates from the SuperCOSMOS Sky Surveys (SSS) and confirmed using data from the Two Micron All Sky Survey (2MASS). Follow-up observations with the near-infrared sensitive SOFI instrument on the ESO 3.5-m New Technology Telescope (NTT) at the La Silla Observatory confirmed its nature and has allowed measurements of its physical properties. Epsilon Indi B has a mass just 45 times that of Jupiter, the largest planet in the Solar System, and a surface temperature of only 1000 °C. It belongs to the so-called 'T dwarf' category of objects which straddle the domain between stars and giant planets. Epsilon Indi B is the nearest and brightest T dwarf known. Future studies of the new object promise to provide astronomers with important new clues as to the formation and evolution of these exotic celestial bodies, at the same time yielding interesting insights into the border zone between planets and stars. TINY MOVING NEEDLES IN GIANT HAYSTACKS ESO PR Photo 03a/03 ESO PR Photo 03a/03 [Preview - JPEG: 400 x 605 pix - 92k [Normal - JPEG: 1200 x 1815 pix - 1.0M] Caption: PR Photo 03a/03 shows Epsilon Indi A (the bright star at far right) and its newly discovered brown dwarf companion Epsilon Indi B (circled). The upper image comes from one of the SuperCOSMOS Sky

  17. Factors that facilitate or inhibit interest of domestic students in the engineering PhD: A mixed methods study

    Science.gov (United States)

    Howell Smith, Michelle C.

    Given the increasing complexity of technology in our society, the United States has a growing demand for a more highly educated technical workforce. Unfortunately, the proportion of United States citizens earning a PhD in engineering has been declining and there is concern about meeting the economic, national security and quality of life needs of our country. This mixed methods sequential exploratory instrument design study identified factors that facilitate or inhibit interest in engineering PhD programs among domestic engineering undergraduate students in the United States. This study developed a testable theory for how domestic students become interested in engineering PhD programs and a measure of that process, the Exploring Engineering Interest Inventory (EEII). The study was conducted in four phases. The first phase of the study was a qualitative grounded theory exploration of interest in the engineering PhD. Qualitative data were collected from domestic engineering students, engineering faculty and industry professional who had earned a PhD in engineering. The second phase, instrument development, developed the Exploring Engineering Interest Inventory (EEII), a measurement instrument designed with good psychometric properties to test a series of preliminary hypotheses related to the theory generated in the qualitative phase. In the third phase of the study, the EEII was used to collect data from a larger sample of junior and senior engineering majors. The fourth phase integrated the findings from the qualitative and quantitative phases. Four factors were identified as being significant influences of interest in the engineering PhD: Personal characteristics, educational environment, misperceptions of the economic and personal costs, and misperceptions of engineering work. Recommendations include increasing faculty encouragement of students to pursue an engineering PhD and programming to correct the misperceptions of the costs of the engineering PhD and the

  18. Assessing the allelotypic effect of two aminocyclopropane carboxylic acid synthase-encoding genes MdACS1 and MdACS3a on fruit ethylene production and softening in Malus

    Science.gov (United States)

    Dougherty, Laura; Zhu, Yuandi; Xu, Kenong

    2016-01-01

    Phytohormone ethylene largely determines apple fruit shelf life and storability. Previous studies demonstrated that MdACS1 and MdACS3a, which encode 1-aminocyclopropane-1-carboxylic acid synthases (ACS), are crucial in apple fruit ethylene production. MdACS1 is well-known to be intimately involved in the climacteric ethylene burst in fruit ripening, while MdACS3a has been regarded a main regulator for ethylene production transition from system 1 (during fruit development) to system 2 (during fruit ripening). However, MdACS3a was also shown to have limited roles in initiating the ripening process lately. To better assess their roles, fruit ethylene production and softening were evaluated at five time points during a 20-day post-harvest period in 97 Malus accessions and in 34 progeny from 2 controlled crosses. Allelotyping was accomplished using an existing marker (ACS1) for MdACS1 and two markers (CAPS866 and CAPS870) developed here to specifically detect the two null alleles (ACS3a-G289V and Mdacs3a) of MdACS3a. In total, 952 Malus accessions were allelotyped with the three markers. The major findings included: The effect of MdACS1 was significant on fruit ethylene production and softening while that of MdACS3a was less detectable; allele MdACS1–2 was significantly associated with low ethylene and slow softening; under the same background of the MdACS1 allelotypes, null allele Mdacs3a (not ACS3a-G289V) could confer a significant delay of ethylene peak; alleles MdACS1–2 and Mdacs3a (excluding ACS3a-G289V) were highly enriched in M. domestica and M. hybrid when compared with those in M. sieversii. These findings are of practical implications in developing apples of low and delayed ethylene profiles by utilizing the beneficial alleles MdACS1-2 and Mdacs3a. PMID:27231553

  19. MdMYB1 Regulates Anthocyanin and Malate Accumulation by Directly Facilitating Their Transport into Vacuoles in Apples.

    Science.gov (United States)

    Hu, Da-Gang; Sun, Cui-Hui; Ma, Qi-Jun; You, Chun-Xiang; Cheng, Lailiang; Hao, Yu-Jin

    2016-03-01

    Tonoplast transporters, including proton pumps and secondary transporters, are essential for plant cell function and for quality formation of fleshy fruits and ornamentals. Vacuolar transport of anthocyanins, malate, and other metabolites is directly or indirectly dependent on the H(+)-pumping activities of vacuolar H(+)-ATPase (VHA) and/or vacuolar H(+)-pyrophosphatase, but how these proton pumps are regulated in modulating vacuolar transport is largely unknown. Here, we report a transcription factor, MdMYB1, in apples that binds to the promoters of two genes encoding the B subunits of VHA, MdVHA-B1 and MdVHA-B2, to transcriptionally activate its expression, thereby enhancing VHA activity. A series of transgenic analyses in apples demonstrates that MdMYB1/10 controls cell pH and anthocyanin accumulation partially by regulating MdVHA-B1 and MdVHA-B2. Furthermore, several other direct target genes of MdMYB10 are identified, including MdVHA-E2, MdVHP1, MdMATE-LIKE1, and MdtDT, which are involved in H(+)-pumping or in the transport of anthocyanins and malates into vacuoles. Finally, we show that the mechanism by which MYB controls malate and anthocyanin accumulation in apples also operates in Arabidopsis (Arabidopsis thaliana). These findings provide novel insights into how MYB transcription factors directly modulate the vacuolar transport system in addition to anthocyanin biosynthesis, consequently controlling organ coloration and cell pH in plants. PMID:26637549

  20. 76 FR 66968 - Abelardo E. Lecompte-Torres, M.D. Decision and Order

    Science.gov (United States)

    2011-10-28

    ... wire fraud, in violation of 18 U.S.C. 1349; and conspiracy to commit money laundering, in violation of... make plain, possessing authority under state law (or in the case of Puerto Rico, the law of the... registration. Steven B. Brown, 75 FR 65660, 65663 (2010) (citing John B. Freitas, 74 FR 17524, 17525...

  1. MD5算法在档案管理系统中的应用%Application of MD5 Algorithm in File Management System

    Institute of Scientific and Technical Information of China (English)

    徐宝清; 赵乾宗

    2015-01-01

    along with the country to the information development and the culture education the increasing attention, the file man⁃agement system is becoming more and more popular. At the same time, with the increase of the amount of archives and the amount of users, the file management system is developing towards more automatic and humane direction.. In order to make the system more accord with the safety standards, the system will use MD5 encryption algorithm for user identity authentication.%随着国家对信息化发展和文化教育的日益重视,档案管理系统正变得越来越普及。与此同时,伴随着档案量和用户量的不断增加,档案管理系统也向着更加自动化和人性化的方向发展。为了使系统更加符合安全标准,系统将采用MD5加密算法对用户身份进行有效认证。

  2. Deletion of the BAC sequences from recombinant meq-null Marek's disease (MD) virus increases immunosuppression while maintaining protective efficacy against MD.

    Science.gov (United States)

    Su, S; Cui, N; Li, J; Sun, P; Li, H; Li, Y; Cui, Z

    2016-07-01

    Marek's disease virus (MDV) GX0101 is a field strain of MDV with a naturally occurring insertion of the reticuloendotheliosis virus (REV) long terminal repeat (LTR) fragment. Both copies of the meq gene were knocked out in the GX0101 bacterial artificial chromosome (BAC) clone to construct the recombinant virus SC9-1, resulting in a complete lack of pathogenicity and providing better protection against MD than CVI988/Rispens. In the present study, the BAC sequences in SC9-1 were removed using a cre-loxP system, and the virus termed SC9-2. SC9-2 showed a significant increase in replication in vitro and in vivo. There was a significant decrease in chicken weight, immune organ index, and antibody levels compared with those of SC9-1-inoculated chickens. The immune protection index of SC9-2 was similar to that of SC9-1, and the difference was not significant. The results of our studies demonstrate that the SC9-2 virus provides protection in specific pathogen free (SPF) chickens when challenged with a very virulent MDV rMd5, but it induces immunosuppressive effects in SPF chickens. PMID:26957626

  3. Technical and economic aspects of brown coal gasification and liquefaction

    International Nuclear Information System (INIS)

    A number of gasification and liquefaction processes for Rhenish brown coal are investigated along with the technical and economic aspects of coal beneficiation. The status of coal beneficiation and the major R + D activities are reviewed. (orig.)

  4. Depletions at Browns Park National Wildlife Refuge [Draft

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Estimated depletion associated with the operation of Spitzie Marsh in Browns Park National Wildlife Refuge. Attached are the methods used to estimate depletion....

  5. Regulatory circuits controlling white versus brown adipocyte differentiation

    DEFF Research Database (Denmark)

    Hansen, Jacob B; Kristiansen, Karsten

    2006-01-01

    Adipose tissue is a major endocrine organ that exerts a profound influence on whole-body homoeostasis. Two types of adipose tissue exist in mammals: WAT (white adipose tissue) and BAT (brown adipose tissue). WAT stores energy and is the largest energy reserve in mammals, whereas BAT, expressing UCP......1 (uncoupling protein 1), can dissipate energy through adaptive thermogenesis. In rodents, ample evidence supports BAT as an organ counteracting obesity, whereas less is known about the presence and significance of BAT in humans. Despite the different functions of white and brown adipocytes......, knowledge of factors differentially influencing the formation of white and brown fat cells is sparse. Here we summarize recent progress in the molecular understanding of white versus brown adipocyte differentiation, including novel insights into transcriptional and signal transduction pathways. Since...

  6. Rüütel, Halonen ja Brown? / Eve Heinla

    Index Scriptorium Estoniae

    Heinla, Eve, 1966-

    2006-01-01

    James Browni kontserdil 27. juulil Tallinna laulukaare all loodetakse kaasa tõmmata ka poliitikud. Ameerika soulmuusik James Brown esitas president Arnold Rüütlile kutse laulda koos temaga duetti. Lisa: Rüütlil siiani Annaniga laulmata

  7. Integrated Pest Management Plan Browns Park National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of the Integrated Pest Management Plan is to provide a comprehensive, environmentally sensitive approach to managing pests on the Browns Park National...

  8. Brown Trout Distribution, Pacific Northwest (updated March, 2006)

    Data.gov (United States)

    Pacific States Marine Fisheries Commission — This dataset is a record of fish distribution and activity for BROWN TROUT contained in the StreamNet database. This feature class was created based on linear event...

  9. A Management Strategy for Kenai Peninsula Brown Bears

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Increasing human activity and land development on the Kenai Peninsula, Alaska has brought about concern for the brown bear Ursus arctos population. The human...

  10. NOAA Ship Ronald Brown Underway Meteorological Data, Quality Controlled

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Ship Ronald Brown Underway Meteorological Data (delayed ~10 days for quality control) are from the Shipboard Automated Meteorological and Oceanographic System...

  11. NOAA Ship Ronald Brown Underway Meteorological Data, Near Real Time

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Ship Ronald Brown Underway Meteorological Data (Near Real Time, updated daily) are from the Shipboard Automated Meteorological and Oceanographic System (SAMOS)...

  12. Reanimating Storywork: Indigenous Elders’ Reflections on Leadership by Lee Brown

    OpenAIRE

    Brown, Lee

    2011-01-01

    Cherokee Elder Dr. Lee Brown explores leadership by discussing the suppression of Aboriginal emotions through colonialism, the importance of cultural values and ceremony, and the need for education reform.

  13. Canine tooth wear in captive little brown bats

    Science.gov (United States)

    Clark, D.R., Jr.

    1980-01-01

    Upper canine teeth of little brown bats Myotis lucifugus lucifugus held in stainless steel wire mesh cages underwent severe wear which exceeded that observed previously in caged big brown bats, Eptesicus fuscus fuscus. This suggests a relationship between amount of wear and size of the caged bats with damage increasing as size decreases. Rapid wear of canine teeth by little brown bats resembled that observed in big brown bats in that it was limited to the first 2 weeks of captivity. This result indicates a universal interval for acclimation to cage conditions among vespertilionid bats. Dietary toxicants DDE and PCB did not affect the extent of wear. If bats are to be released to the wild, confinement in wire mesh cages should be avoided.

  14. Narrative report: Browns Park National Wildlife Refuge: 1972

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Browns Park National Wildlife Refuge outlines Refuge accomplishments during the 1972 calendar year. The report begins by...

  15. Kimberly S. Brown named director of academic advising

    OpenAIRE

    Owczarski, Mark

    2010-01-01

    Kimberly S. Brown, who had been serving as interim associate vice provost for academic support services at Virginia Tech, has been named the university's director of academic advising in the Division of Undergraduate Education.

  16. Exponential decay of eigenfunctions of Brown-Ravenhall operators

    OpenAIRE

    Morozov, Sergey

    2009-01-01

    We prove the exponential decay of eigenfunctions of reductions of Brown-Ravenhall operators to arbitrary irreducible representations of rotation-reflection and permutation symmetry groups under the assumption that the corresponding eigenvalues are below the essential spectrum.

  17. Narrative report : Browns Park National Wildlife Refuge 1968

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Browns Park National Wildlife Refuge outlines Refuge accomplishments during the 1968 calendar year. The report begins by...

  18. ASK1 signalling regulates brown and beige adipocyte function.

    Science.gov (United States)

    Hattori, Kazuki; Naguro, Isao; Okabe, Kohki; Funatsu, Takashi; Furutani, Shotaro; Takeda, Kohsuke; Ichijo, Hidenori

    2016-01-01

    Recent studies suggest that adult humans have active brown or beige adipocytes, the activation of which might be a therapeutic strategy for the treatment of diverse metabolic diseases. Here we show that the protein kinase ASK1 regulates brown and beige adipocytes function. In brown or white adipocytes, the PKA-ASK1-p38 axis is activated in response to cAMP signalling and contributes to the cell-autonomous induction of genes, including Ucp1. Global and fat-specific ASK1 deficiency leads to impaired metabolic responses, including thermogenesis and oxygen consumption, at the cell and whole-body levels, respectively. Our data thus indicate that the ASK1 signalling axis is a regulator of brown and beige adipocyte gene expression and function. PMID:27045525

  19. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools.

    Science.gov (United States)

    Franciscovich, Amy; Vaidya, Dhananjay; Doyle, Joe; Bolinger, Josh; Capdevila, Montserrat; Rice, Marcus; Hancock, Leslie; Mahr, Tanya; Mogul, Douglas B

    2015-01-01

    Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 and wrapped to work on iOS and Android platforms. In order to define the gold standard regarding stool color, seven pediatricians were asked to review 45 photographs of infant stool and rate them as acholic, normal, or indeterminate. Samples for which 6+ pediatricians demonstrated agreement defined the gold standard, and only these samples were included in the analysis. Accuracy of PoopMD was assessed using an iPhone 5s with incandescent lighting. Variability in analysis of stool photographs as acholic versus normal with intermediate rating weighted as 50% agreement (kappa) was compared between three laypeople and one expert user. Variability in output was also assessed between an iPhone 5s and a Samsung Galaxy S4, as well as between incandescent lighting and compact fluorescent lighting. Six-plus pediatricians agreed on 27 normal and 7 acholic photographs; no photographs were defined as indeterminate. The sensitivity was 7/7 (100%). The specificity was 24/27 (89%) with 3/27 labeled as indeterminate; no photos of normal stool were labeled as acholic. The Laplace-smoothed positive likelihood ratio was 6.44 (95% CI 2.52 to 16.48) and the negative likelihood ratio was 0.13 (95% CI 0.02 to 0.83). kappauser was 0.68, kappaphone was 0.88, and kappalight was 0.81. Therefore, in this pilot study, PoopMD accurately differentiates acholic from normal color with substantial agreement across users, and almost perfect agreement across two popular smartphones and ambient light settings. PoopMD

  20. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools.

    Directory of Open Access Journals (Sweden)

    Amy Franciscovich

    Full Text Available Biliary atresia (BA is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 and wrapped to work on iOS and Android platforms. In order to define the gold standard regarding stool color, seven pediatricians were asked to review 45 photographs of infant stool and rate them as acholic, normal, or indeterminate. Samples for which 6+ pediatricians demonstrated agreement defined the gold standard, and only these samples were included in the analysis. Accuracy of PoopMD was assessed using an iPhone 5s with incandescent lighting. Variability in analysis of stool photographs as acholic versus normal with intermediate rating weighted as 50% agreement (kappa was compared between three laypeople and one expert user. Variability in output was also assessed between an iPhone 5s and a Samsung Galaxy S4, as well as between incandescent lighting and compact fluorescent lighting. Six-plus pediatricians agreed on 27 normal and 7 acholic photographs; no photographs were defined as indeterminate. The sensitivity was 7/7 (100%. The specificity was 24/27 (89% with 3/27 labeled as indeterminate; no photos of normal stool were labeled as acholic. The Laplace-smoothed positive likelihood ratio was 6.44 (95% CI 2.52 to 16.48 and the negative likelihood ratio was 0.13 (95% CI 0.02 to 0.83. kappauser was 0.68, kappaphone was 0.88, and kappalight was 0.81. Therefore, in this pilot study, PoopMD accurately differentiates acholic from normal color with substantial agreement across users, and almost perfect agreement across two popular smartphones and ambient light